Guide to the Human Genome
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Search of human proteins with 239742245

BLASTP 2.2.11 [Jun-05-2005]


Reference: Altschul, Stephen F., Thomas L. Madden, Alejandro A. Schaffer, 
Jinghui Zhang, Zheng Zhang, Webb Miller, and David J. Lipman (1997), 
"Gapped BLAST and PSI-BLAST: a new generation of protein database search
programs",  Nucleic Acids Res. 25:3389-3402.

Query= gi|239742245 PREDICTED: hypothetical protein XP_002342464 [Homo
sapiens]
         (424 letters)

Database: hs.faa 
           37,866 sequences; 18,247,518 total letters

Searching..................................................done

                                                                 Score    E
Sequences producing significant alignments:                      (bits) Value

gi|239742245 PREDICTED: hypothetical protein XP_002342464 [Homo ...   874   0.0  
gi|239753797 PREDICTED: hypothetical protein [Homo sapiens]           485   e-137
gi|239748346 PREDICTED: hypothetical protein XP_002346641 [Homo ...   432   e-121
gi|18079216 CASK interacting protein 1 [Homo sapiens]                  44   2e-04
gi|116292168 KRAB A domain containing 1 [Homo sapiens]                 44   2e-04
gi|42475970 synapse defective 1, Rho GTPase, homolog 1 [Homo sap...    44   3e-04
gi|239751637 PREDICTED: hypothetical protein FLJ22184 [Homo sapi...    43   5e-04
gi|239741486 PREDICTED: hypothetical protein XP_002342213 [Homo ...    42   0.001
gi|116284398 WAS/WASL interacting protein family, member 1 [Homo...    42   0.001
gi|38373695 WAS/WASL interacting protein family, member 1 [Homo ...    42   0.001
gi|95147555 microtubule-associated protein 1A [Homo sapiens]           41   0.002
gi|217416343 fibrosin-like 1 [Homo sapiens]                            39   0.007
gi|194578898 hypothetical protein LOC100170841 [Homo sapiens]          39   0.007
gi|24797153 faciogenital dysplasia protein [Homo sapiens]              39   0.009
gi|32455273 WNK lysine deficient protein kinase 2 [Homo sapiens]       39   0.012
gi|146134388 YLP motif containing 1 [Homo sapiens]                     39   0.012
gi|55741677 SET domain containing 1A [Homo sapiens]                    38   0.015
gi|239753975 PREDICTED: hypothetical protein [Homo sapiens]            38   0.020
gi|207113164 Treacher Collins-Franceschetti syndrome 1 isoform f...    38   0.020
gi|207113162 Treacher Collins-Franceschetti syndrome 1 isoform e...    38   0.020
gi|207113160 Treacher Collins-Franceschetti syndrome 1 isoform d...    38   0.020
gi|57164975 Treacher Collins-Franceschetti syndrome 1 isoform b ...    38   0.020
gi|57164977 Treacher Collins-Franceschetti syndrome 1 isoform a ...    38   0.020
gi|57164979 Treacher Collins-Franceschetti syndrome 1 isoform c ...    38   0.020
gi|50345997 E1A binding protein p300 [Homo sapiens]                    37   0.026
gi|7662046 myeloid/lymphoid or mixed-lineage leukemia 4 [Homo sa...    37   0.026
gi|19924099 synapsin I isoform Ia [Homo sapiens]                       37   0.026
gi|19924097 synapsin I isoform Ib [Homo sapiens]                       37   0.026
gi|148236531 hypothetical protein LOC339779 [Homo sapiens]             37   0.026
gi|226437579 NAC alpha domain containing [Homo sapiens]                37   0.034

>gi|239742245 PREDICTED: hypothetical protein XP_002342464 [Homo
           sapiens]
          Length = 424

 Score =  874 bits (2257), Expect = 0.0
 Identities = 424/424 (100%), Positives = 424/424 (100%)

Query: 1   MGAALLAALSSILSHLPAVRTQLGGGAFHNEGPEFRGCVLSPPFPKPRHWLSCTCGGEHE 60
           MGAALLAALSSILSHLPAVRTQLGGGAFHNEGPEFRGCVLSPPFPKPRHWLSCTCGGEHE
Sbjct: 1   MGAALLAALSSILSHLPAVRTQLGGGAFHNEGPEFRGCVLSPPFPKPRHWLSCTCGGEHE 60

Query: 61  NKELPLHQSTGRLLSCLPTRRGHSRSALQKNRLHCPTEGPTNQTPYIKGTEGNGPGLGPQ 120
           NKELPLHQSTGRLLSCLPTRRGHSRSALQKNRLHCPTEGPTNQTPYIKGTEGNGPGLGPQ
Sbjct: 61  NKELPLHQSTGRLLSCLPTRRGHSRSALQKNRLHCPTEGPTNQTPYIKGTEGNGPGLGPQ 120

Query: 121 EEPPAPLTSQPERSSSQRARGKTPSSPTLSPSRGSPLLLREPSLVTDSLEAHRPCPCPPQ 180
           EEPPAPLTSQPERSSSQRARGKTPSSPTLSPSRGSPLLLREPSLVTDSLEAHRPCPCPPQ
Sbjct: 121 EEPPAPLTSQPERSSSQRARGKTPSSPTLSPSRGSPLLLREPSLVTDSLEAHRPCPCPPQ 180

Query: 181 PNQLAPQLSSAPAQLVWAETHSLALPRPNGPESLTWVIFRKSKDGRVHLASSSRLRLRRL 240
           PNQLAPQLSSAPAQLVWAETHSLALPRPNGPESLTWVIFRKSKDGRVHLASSSRLRLRRL
Sbjct: 181 PNQLAPQLSSAPAQLVWAETHSLALPRPNGPESLTWVIFRKSKDGRVHLASSSRLRLRRL 240

Query: 241 LFPLSTQGCERHRSSPRRPPSAGVDVGLLLAQGRGVPAPASRSCERDGRRLVEGKQDSAE 300
           LFPLSTQGCERHRSSPRRPPSAGVDVGLLLAQGRGVPAPASRSCERDGRRLVEGKQDSAE
Sbjct: 241 LFPLSTQGCERHRSSPRRPPSAGVDVGLLLAQGRGVPAPASRSCERDGRRLVEGKQDSAE 300

Query: 301 HQSGPEPALPSLLSTKPPLAEDGRGVAGEVGPVDHTALLGRTAPGLPCRVALPPLSHRLL 360
           HQSGPEPALPSLLSTKPPLAEDGRGVAGEVGPVDHTALLGRTAPGLPCRVALPPLSHRLL
Sbjct: 301 HQSGPEPALPSLLSTKPPLAEDGRGVAGEVGPVDHTALLGRTAPGLPCRVALPPLSHRLL 360

Query: 361 ETGVQTLELPGRQGDRQRTSSSGSDKDRQCRLVGGAVDEPVLSLGSTVLAAPRPAPGRGD 420
           ETGVQTLELPGRQGDRQRTSSSGSDKDRQCRLVGGAVDEPVLSLGSTVLAAPRPAPGRGD
Sbjct: 361 ETGVQTLELPGRQGDRQRTSSSGSDKDRQCRLVGGAVDEPVLSLGSTVLAAPRPAPGRGD 420

Query: 421 CGCH 424
           CGCH
Sbjct: 421 CGCH 424


>gi|239753797 PREDICTED: hypothetical protein [Homo sapiens]
          Length = 864

 Score =  485 bits (1248), Expect = e-137
 Identities = 293/455 (64%), Positives = 303/455 (66%), Gaps = 88/455 (19%)

Query: 42  PPFPKPRHWLSCTCGGEHENKELPLHQSTGRLLSCLPTRRGHSRSALQKNRLHCPTEGP- 100
           PP P          GG H   +L     TG LL C P   G  ++A        PT    
Sbjct: 426 PPAPLTSQPERAGAGGSHGPDQL-----TGNLL-CAP---GQVQAAAM-----APTSSQE 471

Query: 101 TNQTPYIKGTEGNGPGLGPQE--------------EPPAPLTSQPE------RSSSQRAR 140
           T   P+  G  G G   GP +                 AP +SQ        RSSSQRAR
Sbjct: 472 TYSVPW--GRAGAGGSRGPDQLTGNLLCAPGQVPAAAVAPTSSQETYSVPQGRSSSQRAR 529

Query: 141 GKTPSSPTLSPSRGSPLLLREPSLVTDSLEA-------HRPCP-----------CPPQPN 182
           GKTPSSPTLSPSRGSPLLLREPSLVTDSLEA       H  C            C  +  
Sbjct: 530 GKTPSSPTLSPSRGSPLLLREPSLVTDSLEAHRVNTVAHADCTTHARDAGLELGCAYRVR 589

Query: 183 QLAPQLS----SAPAQLVWAETHSLAL--------PRPNG-------------------- 210
           Q+  Q S     A AQ   A   S  +        P+  G                    
Sbjct: 590 QVQAQHSRGADDAQAQPTRARQCSHTMDSSTHIYSPQRQGMGKPVARRMGLGMRVQGAAK 649

Query: 211 -PESLTWVIFRKSKDGRVHLASSSRLRLRRLLFPLSTQGCERHRSSPRRPPSAGVDVGLL 269
             ESLTWVIFRKSKDGRVHLASSSRLRLRRLLFPLSTQGCERHRSSPRRPPSAGVDVGLL
Sbjct: 650 ATESLTWVIFRKSKDGRVHLASSSRLRLRRLLFPLSTQGCERHRSSPRRPPSAGVDVGLL 709

Query: 270 LAQGRGVPAPASRSCERDGRRLVEGKQDSAEHQSGPEPALPSLLSTKPPLAEDGRGVAGE 329
           LAQGRGVPAPASRSCERDGRRLVEGKQDSAEHQSGPEPALPSLLSTKPPLAEDGRGVAGE
Sbjct: 710 LAQGRGVPAPASRSCERDGRRLVEGKQDSAEHQSGPEPALPSLLSTKPPLAEDGRGVAGE 769

Query: 330 VGPVDHTALLGRTAPGLPCRVALPPLSHRLLETGVQTLELPGRQGDRQRTSSSGSDKDRQ 389
           VGPVDHTALLGRTAPGLPCRVALPPLSHRLLETGVQTLELPGRQGDRQRTSSSGSDKDRQ
Sbjct: 770 VGPVDHTALLGRTAPGLPCRVALPPLSHRLLETGVQTLELPGRQGDRQRTSSSGSDKDRQ 829

Query: 390 CRLVGGAVDEPVLSLGSTVLAAPRPAPGRGDCGCH 424
           CRLVGGAVDEPVLSLGSTVLAAPRPAPGRGDCGCH
Sbjct: 830 CRLVGGAVDEPVLSLGSTVLAAPRPAPGRGDCGCH 864



 Score =  132 bits (333), Expect = 5e-31
 Identities = 61/77 (79%), Positives = 65/77 (84%)

Query: 65  PLHQSTGRLLSCLPTRRGHSRSALQKNRLHCPTEGPTNQTPYIKGTEGNGPGLGPQEEPP 124
           P   + G    CLPTRRGHSRSALQKNRLHCPTEGPTNQTPYIKGTEGNGPGLGPQEEPP
Sbjct: 368 PAGPTKGLKCPCLPTRRGHSRSALQKNRLHCPTEGPTNQTPYIKGTEGNGPGLGPQEEPP 427

Query: 125 APLTSQPERSSSQRARG 141
           APLTSQPER+ +  + G
Sbjct: 428 APLTSQPERAGAGGSHG 444



 Score = 74.7 bits (182), Expect = 1e-13
 Identities = 73/216 (33%), Positives = 91/216 (42%), Gaps = 53/216 (24%)

Query: 48  RHWLSCTCGGEHENKELPLHQSTGRLLSCLPTRRGHSRS------------------ALQ 89
           RHWLSCTCGGEHENKELPLHQSTGRLLSC    RG ++S                   LQ
Sbjct: 282 RHWLSCTCGGEHENKELPLHQSTGRLLSC----RGKTKSRPTVGDTAEQPPPHQNFLQLQ 337

Query: 90  KNRLHCPTEGPTNQTPYIKGTEG-----NGPGLGPQEE---PPAPLTSQPERSSSQRAR- 140
           +  L  P +GP+  T      +G      G   GP +    P  P      RS+ Q+ R 
Sbjct: 338 QQPLSIP-KGPSIHTRQQANPQGCPRPQAGDPAGPTKGLKCPCLPTRRGHSRSALQKNRL 396

Query: 141 -----GKTPSSPTLSPSRGSPLLL---REPSLVTDSLEAHRPCPCPPQPNQLAPQLSSAP 192
                G T  +P +  + G+   L    EP     S            P+QL   L  AP
Sbjct: 397 HCPTEGPTNQTPYIKGTEGNGPGLGPQEEPPAPLTSQPERAGAGGSHGPDQLTGNLLCAP 456

Query: 193 AQLVWA--------ETHSLALPR-----PNGPESLT 215
            Q+  A        ET+S+   R       GP+ LT
Sbjct: 457 GQVQAAAMAPTSSQETYSVPWGRAGAGGSRGPDQLT 492


>gi|239748346 PREDICTED: hypothetical protein XP_002346641 [Homo
           sapiens]
          Length = 894

 Score =  432 bits (1111), Expect = e-121
 Identities = 213/213 (100%), Positives = 213/213 (100%)

Query: 212 ESLTWVIFRKSKDGRVHLASSSRLRLRRLLFPLSTQGCERHRSSPRRPPSAGVDVGLLLA 271
           ESLTWVIFRKSKDGRVHLASSSRLRLRRLLFPLSTQGCERHRSSPRRPPSAGVDVGLLLA
Sbjct: 682 ESLTWVIFRKSKDGRVHLASSSRLRLRRLLFPLSTQGCERHRSSPRRPPSAGVDVGLLLA 741

Query: 272 QGRGVPAPASRSCERDGRRLVEGKQDSAEHQSGPEPALPSLLSTKPPLAEDGRGVAGEVG 331
           QGRGVPAPASRSCERDGRRLVEGKQDSAEHQSGPEPALPSLLSTKPPLAEDGRGVAGEVG
Sbjct: 742 QGRGVPAPASRSCERDGRRLVEGKQDSAEHQSGPEPALPSLLSTKPPLAEDGRGVAGEVG 801

Query: 332 PVDHTALLGRTAPGLPCRVALPPLSHRLLETGVQTLELPGRQGDRQRTSSSGSDKDRQCR 391
           PVDHTALLGRTAPGLPCRVALPPLSHRLLETGVQTLELPGRQGDRQRTSSSGSDKDRQCR
Sbjct: 802 PVDHTALLGRTAPGLPCRVALPPLSHRLLETGVQTLELPGRQGDRQRTSSSGSDKDRQCR 861

Query: 392 LVGGAVDEPVLSLGSTVLAAPRPAPGRGDCGCH 424
           LVGGAVDEPVLSLGSTVLAAPRPAPGRGDCGCH
Sbjct: 862 LVGGAVDEPVLSLGSTVLAAPRPAPGRGDCGCH 894



 Score =  133 bits (334), Expect = 3e-31
 Identities = 101/262 (38%), Positives = 127/262 (48%), Gaps = 38/262 (14%)

Query: 65  PLHQSTGRLLSCLPTRRGHSRSALQKNRLHCPTEGPTNQTPYIKGTEGNGPGLGPQEEPP 124
           P   + G    CLPTRRGHSRSALQKNRLHCPTEGPTNQTPYIKGTEGNGPGLGPQEEPP
Sbjct: 368 PAGPTKGLKCPCLPTRRGHSRSALQKNRLHCPTEGPTNQTPYIKGTEGNGPGLGPQEEPP 427

Query: 125 APLTSQPERSSSQRARGKTPSSPTLSPSRGSPLLLREPSLVTDSLEAHRPCPC------- 177
           APLTSQPER+ +  + G    +  L  + G    ++  ++   S +     P        
Sbjct: 428 APLTSQPERAGAGGSHGPDQLTGNLLCAPGQ---VQAAAMAPTSSQETYSVPWGRAGAGG 484

Query: 178 PPQPNQLAPQLSSAPAQLVWA--------ETHSLALPRPNGPESLTWVIFRKSKDGRVHL 229
              P+QL   L  AP Q+  A        ET+S+    P G  S      +      +  
Sbjct: 485 SRGPDQLTGNLLCAPGQVPAAAVAPTSSQETYSV----PQGRSSSQRARGKTPSSPTLSP 540

Query: 230 ASSSRLRLRRLLFPLSTQGCERHR-------SSPRRPPSAGVDVGLLLAQGRGVPAPASR 282
           +  S L LR     L T   E HR               AG+++G    + R V A  SR
Sbjct: 541 SRGSPLLLREP--SLVTDSLEAHRVNTVAHADCTTHARDAGLELGCAY-RVRQVQAQHSR 597

Query: 283 SCERDGRRLVEGKQDSAEHQSG 304
             +      V  ++ +A H SG
Sbjct: 598 GAD------VSEREHAAVHMSG 613



 Score = 74.7 bits (182), Expect = 1e-13
 Identities = 73/216 (33%), Positives = 91/216 (42%), Gaps = 53/216 (24%)

Query: 48  RHWLSCTCGGEHENKELPLHQSTGRLLSCLPTRRGHSRS------------------ALQ 89
           RHWLSCTCGGEHENKELPLHQSTGRLLSC    RG ++S                   LQ
Sbjct: 282 RHWLSCTCGGEHENKELPLHQSTGRLLSC----RGKTKSRPTVGDTAEQPPPHQNFLQLQ 337

Query: 90  KNRLHCPTEGPTNQTPYIKGTEG-----NGPGLGPQEE---PPAPLTSQPERSSSQRAR- 140
           +  L  P +GP+  T      +G      G   GP +    P  P      RS+ Q+ R 
Sbjct: 338 QQPLSIP-KGPSIHTRQQANPQGCPRPQAGDPAGPTKGLKCPCLPTRRGHSRSALQKNRL 396

Query: 141 -----GKTPSSPTLSPSRGSPLLL---REPSLVTDSLEAHRPCPCPPQPNQLAPQLSSAP 192
                G T  +P +  + G+   L    EP     S            P+QL   L  AP
Sbjct: 397 HCPTEGPTNQTPYIKGTEGNGPGLGPQEEPPAPLTSQPERAGAGGSHGPDQLTGNLLCAP 456

Query: 193 AQLVWA--------ETHSLALPR-----PNGPESLT 215
            Q+  A        ET+S+   R       GP+ LT
Sbjct: 457 GQVQAAAMAPTSSQETYSVPWGRAGAGGSRGPDQLT 492


>gi|18079216 CASK interacting protein 1 [Homo sapiens]
          Length = 1431

 Score = 44.3 bits (103), Expect = 2e-04
 Identities = 47/171 (27%), Positives = 64/171 (37%), Gaps = 18/171 (10%)

Query: 42   PPFPKPRHWLSCTCGGEHENKELPLHQSTGRLLSCLPTRRGHSRSALQKNRLHCPTEGPT 101
            PP P P         GE      P       L   +P  +G      +K     P  GP 
Sbjct: 1209 PPLPPPE--------GEARKPAKPPVSPKPVLTQPVPKLQGSPTPTSKK----VPLPGPG 1256

Query: 102  NQTPYIKGTEGNGPGLGPQEEPPAPLTSQPERSSSQRARGKTPSSPTLSPSRGSPLLLRE 161
            +  P +K   G  P + P+  PP P   +P ++ +    G    SP  SP+R  P  L +
Sbjct: 1257 S--PEVKRAHGTPPPVSPKPPPP-PTAPKPVKAVAGLPSGSAGPSPAPSPARQPPAALAK 1313

Query: 162  PSLVTDSLEAHRPCPCPPQPNQLAPQLSSAPAQLVWAETHSLALPRPNGPE 212
            P     SL A  P   PP P   A  + + P +   A   + A P P  PE
Sbjct: 1314 PPGTPPSLGA-SPAK-PPSPGAPALHVPAKPPRAAAAAAAAAAAP-PAPPE 1361


>gi|116292168 KRAB A domain containing 1 [Homo sapiens]
          Length = 1030

 Score = 44.3 bits (103), Expect = 2e-04
 Identities = 53/177 (29%), Positives = 65/177 (36%), Gaps = 26/177 (14%)

Query: 1   MGAALLAALSSILSHLPAVRTQLGGGAFHNEGPEFRGCVLSPPFPKPRHWLSCTC----- 55
           +G A L  LS+ LS     R  +GGG+  +EG E  GC   P   +PRH L  T      
Sbjct: 11  VGTAELLPLSAFLSPSEPGRA-VGGGSHADEGQEPAGCG-DPQGGQPRHSLHLTALVQLV 68

Query: 56  --------GGEHENKELPLHQSTGRLLS---CLPTRRGHSRSALQKNRLHCPTEGPTNQ- 103
                   G      + P  +S G  L      P           +  L C  +GPT+Q 
Sbjct: 69  KEIPEFLFGEVKGAMDSPESESRGASLDGERASPEAAAAREPCPLRGLLSCLPDGPTSQP 128

Query: 104 ----TPYIKGTEGNGPGLGPQEEPPAPLTSQ---PERSSSQRARGKTPSSPTLSPSR 153
               TP          G G Q  P    T+    P R     A G  PS PT SPSR
Sbjct: 129 HLATTPTDSSCSSGPTGDGVQGSPLPIKTADKPWPTRKEGPGALGGEPSPPTHSPSR 185


>gi|42475970 synapse defective 1, Rho GTPase, homolog 1 [Homo
           sapiens]
          Length = 735

 Score = 43.9 bits (102), Expect = 3e-04
 Identities = 66/238 (27%), Positives = 81/238 (34%), Gaps = 46/238 (19%)

Query: 111 EGNGPGLGPQEEPPAPLTSQPERSSSQRARGKTPSSP--TLSPSRGSPLLLREPSLVTDS 168
           E   P   P+  PP P    PE S   +A  + PSSP  + SP+RG+ L   EPS     
Sbjct: 28  ERGHPAQRPEPSPPEPEPQAPEGS---QAGAEGPSSPEASRSPARGAYLQSLEPSSRRWV 84

Query: 169 LEAHRPC----------------------------PCPPQPNQLAPQLSSAPAQLVWAET 200
           L   +P                             P PP P    PQ  S       AE+
Sbjct: 85  LGGAKPAEDTSLGPGVPGTGEPAGEIWYNPIPEEDPRPPAPEPPGPQPGS-------AES 137

Query: 201 HSLALPRPNGPESLTWVIFRKSKDGRVHLASSSRLRLRRLLFPLSTQGCERHRSSPRRPP 260
             LA P+   P S      R    G     S    +L  L   LS +G    R   R  P
Sbjct: 138 EGLA-PQGAAPASPPTKASRTKSPGPARRLSIKMKKLPELRRRLSLRGPRAGRERERAAP 196

Query: 261 SAGVDVGLLLAQGRGVPAPAS-RSCERDGRRLVEGKQDSAEHQSGPEPALPSLLSTKP 317
           +  V     L    G P PA+     R  R       DS E  +GP    PS  S +P
Sbjct: 197 AGSVISRYHLDSSVGGPGPAAGPGGTRSPRAGYLSDGDSPERPAGP----PSPTSFRP 250



 Score = 30.0 bits (66), Expect = 4.1
 Identities = 20/60 (33%), Positives = 25/60 (41%), Gaps = 14/60 (23%)

Query: 135 SSQRARGKTPSSPTLSPSRGSPLLLREPSLVTDSLEAHRPCPCPPQPNQLAPQLSSAPAQ 194
           S  R R K P   + +  RG P              A RP P PP+P   AP+ S A A+
Sbjct: 11  SRLRGREKLPRKKSDAKERGHP--------------AQRPEPSPPEPEPQAPEGSQAGAE 56


>gi|239751637 PREDICTED: hypothetical protein FLJ22184 [Homo
           sapiens]
          Length = 1124

 Score = 43.1 bits (100), Expect = 5e-04
 Identities = 73/275 (26%), Positives = 92/275 (33%), Gaps = 72/275 (26%)

Query: 115 PGLGPQEEPPAPLTSQPERSSSQRARGKTPSSPTLSPS-----RGSPLLLREPSLVTDSL 169
           P   P  + P PL + P      +     P+SP +SPS     R  PLL   P  V  S 
Sbjct: 718 PSATPPPQAPPPLAAPP-----LQVPPSPPASPPMSPSATPPPRVPPLLAAPPLQVPPSP 772

Query: 170 EAHRP-CPCPPQPNQLAPQLSSAPAQLVWAETHSLALPRPNGPESLTWVIFRKSKDGRVH 228
            A  P  P    P Q  P L++ P Q         ALP P             S  G+  
Sbjct: 773 PASLPMSPLAKPPPQAPPALATPPLQ---------ALPSPPA-----------SFPGQAP 812

Query: 229 LASSSRLRLRRLLFP---------------LSTQGCERHRSSPRRPPSAGVDVG-----L 268
            + S+ L +  L  P                 +        +PRRPP+ G D       L
Sbjct: 813 FSPSASLPMSPLATPPPQAPPVLAAPLLQVPPSPPASPTLQAPRRPPTPGPDTSVSGPRL 872

Query: 269 LLAQGRGVPAPASRSCERDGRRLVEGKQDSAEHQSGPEPALPSLLSTKPPLAEDGRGV-- 326
            LA   G P P SRS               +   SGP+ A  S  +T  P  E+ RG   
Sbjct: 873 TLALAPGPPPPPSRS--------------PSSTLSGPDLAGHSSSATSTP--EELRGYDS 916

Query: 327 ---AGEVGPVDHTALLGRTAPGLPCRVALPPLSHR 358
               G        A L    P    R   PPL+ R
Sbjct: 917 GPEGGAAASPPPDAELAACHPAAWSRGPAPPLAFR 951



 Score = 38.5 bits (88), Expect = 0.012
 Identities = 34/101 (33%), Positives = 42/101 (41%), Gaps = 9/101 (8%)

Query: 115 PGLGPQEEPPAPLTSQPERSSSQRARGKTPSSPTLSPSRGSPLLLREPSLVTDSLEAHRP 174
           P   P + PP+PLT+ P  + S  A   TP  P   P+  SP L   PS     L     
Sbjct: 564 PAPCPLQAPPSPLTTPPPETPSSIA---TP-PPQAPPALASPPLQGLPSPPLSPLAT--- 616

Query: 175 CPCPPQPNQLA-PQLSSAPAQLVWAETHSLALPRPNGPESL 214
            P P  P  LA P L + P+         LA P P  P +L
Sbjct: 617 -PPPQAPPXLALPPLQAPPSPPASPPLSPLATPSPQAPNAL 656



 Score = 37.7 bits (86), Expect = 0.020
 Identities = 46/173 (26%), Positives = 61/173 (35%), Gaps = 18/173 (10%)

Query: 42  PPFPKPRHWLSCTCGGEHENKELPLHQSTGRLLSCLPTRRGHSRSALQKNRLHCPTEGPT 101
           PP   PR   S +   EH   E P   +  R  +    +R  SRS         P   P 
Sbjct: 200 PPTEGPRK--SVSSASEHSTTE-PSPAARRRPSAGGGLQRPASRSLSSSAT---PLSSPA 253

Query: 102 NQTPYIKGTEGNGPGLGPQEEPPAPLTSQPERSSSQRARGKTPSSPTLSPSRGSPLLLRE 161
              P  +GT    P    Q +P      +P + +  R      ++P L P   SPL    
Sbjct: 254 RSGPSARGTP-RAPAHPSQPKPKGLQALRPPQVTPPRK----DAAPALGPLSSSPLATPS 308

Query: 162 PSLVTDSLEAHRPCPCPPQPNQLAPQLSSAPAQLVWAETHSLALPRPNGPESL 214
           PS         +  P PP  N   P  ++ P     A    LA P P+ P SL
Sbjct: 309 PS-------GTKARPVPPPDNAATPLPATLPPSPPLATPLPLAPPSPSAPPSL 354



 Score = 32.0 bits (71), Expect = 1.1
 Identities = 56/216 (25%), Positives = 74/216 (34%), Gaps = 42/216 (19%)

Query: 78  PTRRGHSRSALQKNRLHCPTEGPTNQTPYIKGTEGNGPGLGPQEEPP--------APLTS 129
           P R G S     +   H     P+   P  KG +   P   PQ  PP         PL+S
Sbjct: 252 PARSGPSARGTPRAPAH-----PSQPKP--KGLQALRP---PQVTPPRKDAAPALGPLSS 301

Query: 130 QP---ERSSSQRAR-------GKTPSSPTL--SPSRGSPLLLREPSLVTDSLEAHRPCPC 177
            P      S  +AR         TP   TL  SP   +PL L  PS          P P 
Sbjct: 302 SPLATPSPSGTKARPVPPPDNAATPLPATLPPSPPLATPLPLAPPSPSAPPSLQTLPSPP 361

Query: 178 PPQPNQLAPQLSSAPAQLVWA--------ETHSLALPRPNGPESLTWVIFRKSKDGRVHL 229
              P+Q  P +++ P Q   +          HSL  P    P S    +   S      L
Sbjct: 362 ATPPSQAPPSMTTPPMQAPPSLQTIPPIQVPHSLTSPSLQAPPS---PLALSSLQATTSL 418

Query: 230 ASSSRLRLRRLLFPLSTQGCERHRSSPRRPPSAGVD 265
            S + L+       +S +  +   +SP RP S   D
Sbjct: 419 GSPT-LQATHSFLTMSPRQTQASLTSPSRPASTPPD 453



 Score = 30.4 bits (67), Expect = 3.2
 Identities = 58/253 (22%), Positives = 87/253 (34%), Gaps = 25/253 (9%)

Query: 117 LGPQEEPPAPLTSQPERSSSQRARGKTPSSPTLSPSRGSPLLLREPSLVTDSLEAHRPCP 176
           L P      PL   P   S+  +    PS P   PS+  P +   P     SL+   P  
Sbjct: 331 LPPSPPLATPLPLAPPSPSAPPSLQTLPSPPATPPSQAPPSMTTPPMQAPPSLQTIPPIQ 390

Query: 177 CPPQPNQLAPQLSSAPAQLVWAE---THSLALPRPNGPESLTWVIFRKSKDGRVHLASSS 233
            P   +  +P L + P+ L  +    T SL  P      S   +  R++   +  L S S
Sbjct: 391 VP--HSLTSPSLQAPPSPLALSSLQATTSLGSPTLQATHSFLTMSPRQT---QASLTSPS 445

Query: 234 RLRLR-----RLLFPLSTQGCERHRSSPRRPPSAGVDVGLLLAQGRGVPAPASRSCERDG 288
           R          L  PLS       ++S   P  + +   L +   + + + AS S +   
Sbjct: 446 RPASTPPDSPPLQAPLSLPASPPLQTS-LSPAVSPLSSPLTIHPLQALSSLASHSPQAPL 504

Query: 289 RRLVEGKQDSAEHQSGPEPALPSLLSTKPPLAEDGRGVAGEVGPVDHTALLGRTAPGL-- 346
             L+    ++    + P    P    T PPL      +     P   TA    T P L  
Sbjct: 505 SSLIMPPLETQSSLAPPSLQTPPASLTTPPL----ENLPSLAPPPLQTASAPLTTPHLET 560

Query: 347 -----PCRVALPP 354
                PC +  PP
Sbjct: 561 PPCPAPCPLQAPP 573



 Score = 29.3 bits (64), Expect = 7.1
 Identities = 43/151 (28%), Positives = 51/151 (33%), Gaps = 24/151 (15%)

Query: 74  LSCLPTRRGHSRSALQKNRLHCPTEG------PTNQTPYIKGTEG---NGPGLGPQEEPP 124
           L  L +   HS  A   + +  P E       P+ QTP    T     N P L P   PP
Sbjct: 489 LQALSSLASHSPQAPLSSLIMPPLETQSSLAPPSLQTPPASLTTPPLENLPSLAP---PP 545

Query: 125 APLTSQPERSSSQRARGKTPSSPTLSPSRGSPLLLREPSLVTDSLEAHRPCPCPPQPNQL 184
               S P  +       +TP  P   P +  P  L  P   T       P      P Q 
Sbjct: 546 LQTASAPLTTPHL----ETPPCPAPCPLQAPPSPLTTPPPET-------PSSIATPPPQA 594

Query: 185 APQLSSAPAQ-LVWAETHSLALPRPNGPESL 214
            P L+S P Q L       LA P P  P  L
Sbjct: 595 PPALASPPLQGLPSPPLSPLATPPPQAPPXL 625


>gi|239741486 PREDICTED: hypothetical protein XP_002342213 [Homo
           sapiens]
          Length = 233

 Score = 41.6 bits (96), Expect = 0.001
 Identities = 66/234 (28%), Positives = 83/234 (35%), Gaps = 57/234 (24%)

Query: 128 TSQPERSSSQ----RARGKTPSSPTLSPSRGSPLLLREPSLVTDSLEAHRPCPCPPQPNQ 183
           +S+P  S  Q       G+  +SP  SP R +   L  P++        R CP PP+ + 
Sbjct: 11  SSKPAASGVQSPTFHGSGRQTASP--SPPRCAKTQLTPPAI--------RSCPLPPEEDL 60

Query: 184 LAPQLSSAPAQLVW--AETHSLALPRPNGPESLTWVIFRKSKDGRVHLASSSRLRLRRLL 241
           L PQ  SAP  L+   + T  LAL  P+ P+               H  S SR    R L
Sbjct: 61  LTPQ-GSAPRLLLGEASLTSPLALIPPSEPQ---------------HSPSKSRALCNRGL 104

Query: 242 FPLS---TQGCERHRSSPRRP-------------PSAGVDVGLLLAQGRGVPA------- 278
              S    QG      SP  P             PS G  VG  L  GRG  A       
Sbjct: 105 RSTSRCTQQGLPSVPPSPLTPLPPSPTAPRRSQYPSPGSRVGRGLGTGRGKLAHRVAPSK 164

Query: 279 -PASRSCERDGRRLVEGKQDSAEHQSGPEPALPSLLSTKPPLAEDGRGVAGEVG 331
            P  R+C   GR           H +G  PA         P A +G G    +G
Sbjct: 165 EPPERACGSRGRSTGWAASSPKTHAAGQAPAAARSGRGAGP-AREGSGAPSGLG 217


>gi|116284398 WAS/WASL interacting protein family, member 1 [Homo
           sapiens]
          Length = 503

 Score = 41.6 bits (96), Expect = 0.001
 Identities = 85/352 (24%), Positives = 119/352 (33%), Gaps = 53/352 (15%)

Query: 24  GGGAFHNEGPEFRGCVLSPPFPKPRHWLSCTCGGEHENKELPLHQSTGRLLSCLP--TRR 81
           GGG+F   GP   G +     PK R   +     +      PL    GR  S  P     
Sbjct: 88  GGGSFGGGGPPGLGGLFQAGMPKLRS--TANRDNDSGGSRPPLLPPGGRSTSAKPFSPPS 145

Query: 82  GHSRSAL-QKNRLHCPTEGPTNQTPYIKGTEGNGPGLGPQEEPPAPLTSQPERSS----- 135
           G  R  +        P E   N+ P  +   G+ P   P   PP P T +P +SS     
Sbjct: 146 GPGRFPVPSPGHRSGPPEPQRNRMPPPRPDVGSKPDSIP---PPVPSTPRPIQSSPHNRG 202

Query: 136 ------SQRARGKTPSSPTLSPSRGSPL---LLREPSLVTDSLEAHRPCPCPPQPNQLAP 186
                   R     P+ P    +RG+ L    +R+  L + S  ++RP P PP P++   
Sbjct: 203 SPPVPGGPRQPSPGPTPPPFPGNRGTALGGGSIRQSPLSSSSPFSNRP-PLPPTPSRALD 261

Query: 187 QLSSAPAQLVW--AETHSLALPRPNGPESLTWVIFRKSKDGRVHLASSSRLRLRRLLFPL 244
                P   V      H  A+P P    +      +         ++SS+        P 
Sbjct: 262 DKPPPPPPPVGNRPSIHREAVPPPPPQNN------KPPVPSTPRPSASSQA-------PP 308

Query: 245 STQGCERHRSSPRRPPSAGVDVGLLLAQGRGVPAPASRSCERDGRRLVEGKQDSAEHQSG 304
                 R    P  P S+G D    L Q     + ++      GR             SG
Sbjct: 309 PPPPPSRPGPPPLPPSSSGNDETPRLPQRNLSLSSSTPPLPSPGR-------------SG 355

Query: 305 PEPALPSLLSTKPPLAEDGRGVAGEVGPVDHTALLGRTAPGLPCRVALPPLS 356
           P P  PS     PP   D  G +G + P    +  G T+  LP    LP  S
Sbjct: 356 PLPPPPS--ERPPPPVRDPPGRSGPLPPPPPVSRNGSTSRALPATPQLPSRS 405



 Score = 31.6 bits (70), Expect = 1.4
 Identities = 31/111 (27%), Positives = 41/111 (36%), Gaps = 16/111 (14%)

Query: 101 TNQTPYIKGTEGNGP-GLGPQEEPPAPLTSQPERS-------------SSQRARGKTPSS 146
           ++ TP +     +GP    P E PP P+   P RS             S+ RA   TP  
Sbjct: 342 SSSTPPLPSPGRSGPLPPPPSERPPPPVRDPPGRSGPLPPPPPVSRNGSTSRALPATPQL 401

Query: 147 PTLSPSRGSPLLLREPSLVTDSLEAHRPCPCPPQPNQLAPQLSSAPAQLVW 197
           P+ S    SP     P L  D   A  P P PP    +      +P +  W
Sbjct: 402 PSRS-GVDSPRSGPRPPLPPDRPSAGAP-PPPPPSTSIRNGFQDSPCEDEW 450


>gi|38373695 WAS/WASL interacting protein family, member 1 [Homo
           sapiens]
          Length = 503

 Score = 41.6 bits (96), Expect = 0.001
 Identities = 85/352 (24%), Positives = 119/352 (33%), Gaps = 53/352 (15%)

Query: 24  GGGAFHNEGPEFRGCVLSPPFPKPRHWLSCTCGGEHENKELPLHQSTGRLLSCLP--TRR 81
           GGG+F   GP   G +     PK R   +     +      PL    GR  S  P     
Sbjct: 88  GGGSFGGGGPPGLGGLFQAGMPKLRS--TANRDNDSGGSRPPLLPPGGRSTSAKPFSPPS 145

Query: 82  GHSRSAL-QKNRLHCPTEGPTNQTPYIKGTEGNGPGLGPQEEPPAPLTSQPERSS----- 135
           G  R  +        P E   N+ P  +   G+ P   P   PP P T +P +SS     
Sbjct: 146 GPGRFPVPSPGHRSGPPEPQRNRMPPPRPDVGSKPDSIP---PPVPSTPRPIQSSPHNRG 202

Query: 136 ------SQRARGKTPSSPTLSPSRGSPL---LLREPSLVTDSLEAHRPCPCPPQPNQLAP 186
                   R     P+ P    +RG+ L    +R+  L + S  ++RP P PP P++   
Sbjct: 203 SPPVPGGPRQPSPGPTPPPFPGNRGTALGGGSIRQSPLSSSSPFSNRP-PLPPTPSRALD 261

Query: 187 QLSSAPAQLVW--AETHSLALPRPNGPESLTWVIFRKSKDGRVHLASSSRLRLRRLLFPL 244
                P   V      H  A+P P    +      +         ++SS+        P 
Sbjct: 262 DKPPPPPPPVGNRPSIHREAVPPPPPQNN------KPPVPSTPRPSASSQA-------PP 308

Query: 245 STQGCERHRSSPRRPPSAGVDVGLLLAQGRGVPAPASRSCERDGRRLVEGKQDSAEHQSG 304
                 R    P  P S+G D    L Q     + ++      GR             SG
Sbjct: 309 PPPPPSRPGPPPLPPSSSGNDETPRLPQRNLSLSSSTPPLPSPGR-------------SG 355

Query: 305 PEPALPSLLSTKPPLAEDGRGVAGEVGPVDHTALLGRTAPGLPCRVALPPLS 356
           P P  PS     PP   D  G +G + P    +  G T+  LP    LP  S
Sbjct: 356 PLPPPPS--ERPPPPVRDPPGRSGPLPPPPPVSRNGSTSRALPATPQLPSRS 405



 Score = 31.6 bits (70), Expect = 1.4
 Identities = 31/111 (27%), Positives = 41/111 (36%), Gaps = 16/111 (14%)

Query: 101 TNQTPYIKGTEGNGP-GLGPQEEPPAPLTSQPERS-------------SSQRARGKTPSS 146
           ++ TP +     +GP    P E PP P+   P RS             S+ RA   TP  
Sbjct: 342 SSSTPPLPSPGRSGPLPPPPSERPPPPVRDPPGRSGPLPPPPPVSRNGSTSRALPATPQL 401

Query: 147 PTLSPSRGSPLLLREPSLVTDSLEAHRPCPCPPQPNQLAPQLSSAPAQLVW 197
           P+ S    SP     P L  D   A  P P PP    +      +P +  W
Sbjct: 402 PSRS-GVDSPRSGPRPPLPPDRPSAGAP-PPPPPSTSIRNGFQDSPCEDEW 450


>gi|95147555 microtubule-associated protein 1A [Homo sapiens]
          Length = 2803

 Score = 40.8 bits (94), Expect = 0.002
 Identities = 72/258 (27%), Positives = 95/258 (36%), Gaps = 27/258 (10%)

Query: 71   GRLLSCLPTRRGHSRSALQKNRLHCPTEGPTNQTPYIKGTEGNGPGLGPQEEPPAPLT-S 129
            G +LSC P RR  S S  +  R H   +  T+ +   KG             PP P+   
Sbjct: 2079 GNILSCSPDRR--SPSPKESGRSHW--DDSTSDSELEKGAREQPEKEAQSPSPPHPIPMG 2134

Query: 130  QPERSSSQRARGKTPSSPTLSPSRGSPLLLREPSLVTDSLEAHRPCPCPPQPNQLAPQLS 189
             P       A    P    L P+R S L     +    SL+     P PPQ    A   S
Sbjct: 2135 SPTLWPETEAHVSPPLDSHLGPARPS-LDFPASAFGFSSLQ-----PAPPQLPSPAEPRS 2188

Query: 190  SAPAQLVWAETHSLALPRPNGPESLTWVIFRKSKDGRVHLASSSRLRLRRLLFPLSTQGC 249
            +    L ++   +LAL    GP + T    R  +   V  A S    L +L  P S+ G 
Sbjct: 2189 APCGSLAFSGDRALALAP--GPPTRT----RHDEYLEVTKAPSLDSSLPQLPSP-SSPGA 2241

Query: 250  ERHRSSPRRPPSAGVDVGLLLAQGRGVPAPASRSCERDGRRLVEGKQDSAEHQSGPEPAL 309
                + PR P S  +  G   +         S   ER    L   +Q+S E   G EPA 
Sbjct: 2242 PLLSNLPR-PASPALSEG---SSSEATTPVISSVAERFSPSLEAAEQESGELDPGMEPAA 2297

Query: 310  PSL-----LSTKPPLAED 322
             SL     LS  PP + D
Sbjct: 2298 HSLWDLTPLSPAPPASLD 2315


>gi|217416343 fibrosin-like 1 [Homo sapiens]
          Length = 1045

 Score = 39.3 bits (90), Expect = 0.007
 Identities = 44/153 (28%), Positives = 61/153 (39%), Gaps = 37/153 (24%)

Query: 67  HQSTGRLLSCLPTRRGHSRSALQKNRLHCPTEGPTNQTPYIKGTEGNGPGLGPQEEPPAP 126
           H  +GR  SC        ++++   +L  P            GT+  GP L   E    P
Sbjct: 197 HAVSGRGYSCDSESGPDDKASVGSEKLFAP------------GTD-KGPALEKSEAKAGP 243

Query: 127 LTSQPERSSSQRARGKTPSS--PTLSP-------------SRGSPLLLREPSLVTDSLEA 171
           +   P+ S  +R+R  +  S  PT SP             SR +PL+ +EP     +   
Sbjct: 244 V---PKVSGLERSRELSAESFLPTASPAPHAAPCPGPPPGSRANPLVKKEPP----APHR 296

Query: 172 HRPCPCPPQPNQLAPQLSSAPAQLVWAETHSLA 204
           H P P PPQP  L P  +  PA L     HS A
Sbjct: 297 HTPQPPPPQPRGLLP--THVPASLGAFAGHSQA 327


>gi|194578898 hypothetical protein LOC100170841 [Homo sapiens]
          Length = 379

 Score = 39.3 bits (90), Expect = 0.007
 Identities = 73/266 (27%), Positives = 91/266 (34%), Gaps = 56/266 (21%)

Query: 85  RSALQKNRLHCPTEGPTNQTPYIKGTEGNGPGLGPQEEPPAPLTSQPERSSSQRARGKTP 144
           RS     R   P     + T +        PGL PQ  P A   S P+  SS     + P
Sbjct: 132 RSCAPPGRCPAPPHPRESTTSFASAPPRPAPGLEPQRGPAA---SPPQEPSS-----RPP 183

Query: 145 SSPT-LSPSRGSPLLLREPSLVTDSLEAHRPCPCPPQPNQLAPQLSSAPAQLVWAETHSL 203
           S P  LS     P     P L        +P      P   AP+   AP     A + S 
Sbjct: 184 SPPAGLSTEPAGPGTAPRPFL------PGQPAEVDGNPPPAAPE---AP-----AASPST 229

Query: 204 ALPRPNGPESLTWVIFRKSKDGRVHLASSSRLRLRRLLFPLSTQGCERHRSSPRRPPSAG 263
           A P P  P  L    F +       L   S+L      F L T    R    P RPP+ G
Sbjct: 230 ASPAPAAPGDLRQEHFDR-------LIRRSKLWCYAKGFALDTPSLRR---GPERPPAKG 279

Query: 264 VDVGLLLAQGRGVPAPASRSCERDGRRLVEGKQDSAEHQSGPEPALP-----SLLSTKPP 318
              G   A+ R +PAP  R+ +   RR              P P LP     SLL+  P 
Sbjct: 280 PARG--AAKKRRLPAPPPRTAQ--PRR--------------PAPTLPTTSTFSLLNCFPC 321

Query: 319 LAEDGRGVAGEVGPVDHTALLGRTAP 344
                 G  G++ P     L G + P
Sbjct: 322 PPALVVGEDGDLKPASSLRLQGDSKP 347



 Score = 35.8 bits (81), Expect = 0.076
 Identities = 38/143 (26%), Positives = 57/143 (39%), Gaps = 27/143 (18%)

Query: 80  RRGHSRSALQKNRLHCPTEGPTNQTPYIKGTEGNGPGLGPQEEPPAPLTSQPERSSSQRA 139
           R+ H    +++++L C  +G    TP ++     GP     E PPA     P R ++++ 
Sbjct: 241 RQEHFDRLIRRSKLWCYAKGFALDTPSLR----RGP-----ERPPA---KGPARGAAKKR 288

Query: 140 RGKTPSSPTLSPSRGSPLLLREPSLVTDSLEAHRPCP-----------CPPQPNQLAPQL 188
           R   P   T  P R +P L   P+  T SL    PCP            P    +L    
Sbjct: 289 RLPAPPPRTAQPRRPAPTL---PTTSTFSLLNCFPCPPALVVGEDGDLKPASSLRLQGDS 345

Query: 189 SSAPAQLVWA-ETHSLALPRPNG 210
              PA  +W  +    A+P P G
Sbjct: 346 KPPPAHPLWRWQMGGPAVPEPPG 368


>gi|24797153 faciogenital dysplasia protein [Homo sapiens]
          Length = 961

 Score = 38.9 bits (89), Expect = 0.009
 Identities = 52/191 (27%), Positives = 69/191 (36%), Gaps = 24/191 (12%)

Query: 96  PTEGPTNQTPYIKGTEGNGPGLGPQE------------EPPAPLTSQPERSSSQRARGKT 143
           PTE P+ +   +K   G  P + P+             EP  P  S+P  +  + A+G  
Sbjct: 140 PTETPSQRPSPLKRAPGPKPQVPPKPSYLQMPRMPPPLEPIPPPPSRPLPADPRVAKGLA 199

Query: 144 PSSPTLSPSRGSPLLL----REPSLVTDSLEAHRPCPCPPQPNQLAPQLSSAP--AQLVW 197
           P +     S     L+    REP +V        P P PP+P  L PQ +S P   QL  
Sbjct: 200 PRAEASPSSAAVSSLIEKFEREPVIVASDRPVPGPSPGPPEPVML-PQPTSQPPVPQLPE 258

Query: 198 AETHSLALPRPNGPESLTWVIFRKSKDGRVHLASSSRLRLRRLLFPLSTQGCERHRSSPR 257
            E          GP     V  R S    +   S+S        F +S  G   H   P 
Sbjct: 259 GEASRCLFLLAPGPRDGEKVPNRDSGIDSISSPSNS----EETCF-VSDDGPPSHSLCPG 313

Query: 258 RPPSAGVDVGL 268
            P  A V V L
Sbjct: 314 PPALASVPVAL 324


>gi|32455273 WNK lysine deficient protein kinase 2 [Homo sapiens]
          Length = 2217

 Score = 38.5 bits (88), Expect = 0.012
 Identities = 76/297 (25%), Positives = 104/297 (35%), Gaps = 52/297 (17%)

Query: 119  PQEEPPAPLTSQPERSSSQRARGKTPSSPTLSPSRGSPLLLREPSLVTDSLEAH----RP 174
            P+  PP PL+S P  +S   A  K   S     S+  P  L    L++ +  ++     P
Sbjct: 1327 PESSPPLPLSSLPPEASQDSAPYKDQLS-----SKEQPSFLASQQLLSQAGPSNPPGAPP 1381

Query: 175  CPCPPQ--PNQLAPQLSSAPAQLVWAETHSLALPR---PNGPESLTWVIFRKSKDGRVHL 229
             P  P   P    PQ  +APA     E  S    +   P  P+ LT  +         H 
Sbjct: 1382 APLAPSSPPVTALPQDGAAPATSTMPEPASGTASQAGGPGTPQGLTSELETSQPLAETHE 1441

Query: 230  ASSSRLRLRRLLF------PLSTQGCERHRSSPRRP---------PSAGVDVGLLLAQGR 274
            A    L ++ L+       P       R  S+PR P         P +G     L     
Sbjct: 1442 AP---LAVQPLVVGLAPCTPAPEAASTRDASAPREPLPPPAPEPSPHSGTPQPAL----- 1493

Query: 275  GVPAPASRSCERDGRRLVEGKQDSAEHQSGPEPALPSLLSTKPP--LAEDGRGVAGEVGP 332
            G PAP   +          G    A  Q  P P L   +  +PP  L  DG G    VG 
Sbjct: 1494 GQPAPLLPA--------AVGAVSLATSQL-PSPPLGPTVPPQPPSALESDGEGPPPRVGF 1544

Query: 333  VDHT-ALLGRTAPGLPCRVALPPLSHRL---LETGVQTLELPGRQGDRQRTSSSGSD 385
            VD T   L      L  +  +P  S      +E G +   L   +GD+ R+   G D
Sbjct: 1545 VDSTIKSLDEKLRTLLYQEHVPTSSASAGTPVEVGDRDFTLEPLRGDQPRSEVCGGD 1601


>gi|146134388 YLP motif containing 1 [Homo sapiens]
          Length = 2146

 Score = 38.5 bits (88), Expect = 0.012
 Identities = 63/236 (26%), Positives = 86/236 (36%), Gaps = 36/236 (15%)

Query: 115 PGLGPQEEPPAPLTSQPERSS--SQRARGKTPSSPTLS-PSRGSPLLLREPSLVTDSLEA 171
           PG+ P   PP+  TS P      S  + G  P  P  S  S G P +L  PSL + +   
Sbjct: 558 PGMPPPVMPPSLPTSVPPPGMPPSLSSAGPPPVLPPPSLSSAGPPPVLPPPSLSSTAPPP 617

Query: 172 HRPCP----------CPPQ--PNQLAPQLSSAPAQLVWAETHSLALPRPNGPESLTWVIF 219
             P P           PP   P  + PQL++AP     +   S    +P      T V F
Sbjct: 618 VMPLPPLSSATPPPGIPPPGVPQGIPPQLTAAPVPPASSSQSSQVPEKPRPALLPTPVSF 677

Query: 220 RKSKDGRVH--LAS-------SSRLRLRRLLFPLST----QGCERHRSSPRRPPSAGVDV 266
             +     H  L S       +S+  L +   P S+    QG     ++P +P +A  D+
Sbjct: 678 GSAPPTTYHPPLQSAGPSEQVNSKAPLSKSALPYSSFSSDQGLGESSAAPSQPITAVKDM 737

Query: 267 -----GLLLAQGRGVPAPASRSCERDGRRLVEGKQDSAEHQSGPEPALPSLLSTKP 317
                GLL    R     + R    DG R  E   D      GP P  P     +P
Sbjct: 738 PVRSGGLLPDPPRSSYLESPRGPRFDGPRRFE---DLGSRCEGPRPKGPRFEGNRP 790


>gi|55741677 SET domain containing 1A [Homo sapiens]
          Length = 1707

 Score = 38.1 bits (87), Expect = 0.015
 Identities = 30/110 (27%), Positives = 43/110 (39%), Gaps = 11/110 (10%)

Query: 113 NGPGLGPQEEPPAPLTSQPERSSSQRARGKTPSSPTLS-PSRGSPLLLREPSLVTDS--- 168
           +G G GP   PPAP   +    +     G T  SP  +  ++ SP    +   ++D    
Sbjct: 532 SGSGHGPCTPPPAPANFEDVAPTGSGEPGATRESPKANGQNQASPCSSGDDMEISDDDRG 591

Query: 169 -------LEAHRPCPCPPQPNQLAPQLSSAPAQLVWAETHSLALPRPNGP 211
                      +P P PP P    P L+S P      +   L  PRP+GP
Sbjct: 592 GSPPPAPTPPQQPPPPPPPPPPPPPYLASLPLGYPPHQPAYLLPPRPDGP 641


>gi|239753975 PREDICTED: hypothetical protein [Homo sapiens]
          Length = 389

 Score = 37.7 bits (86), Expect = 0.020
 Identities = 28/72 (38%), Positives = 35/72 (48%), Gaps = 5/72 (6%)

Query: 144 PSSPTLSPSRGSPLLLR-EPSLVTDSLEAHRPCPCP---PQPNQLAPQLSSAPAQLVWAE 199
           PSSP  +P+R  P  ++  PS  T   EA  P   P   P+P  L P+ S AP    W +
Sbjct: 112 PSSPH-APTRPPPQAVQPRPSEPTPGSEALPPGSLPEGEPRPYALPPRESPAPRPFRWGD 170

Query: 200 THSLALPRPNGP 211
             S A PRP  P
Sbjct: 171 PFSPAPPRPQPP 182


>gi|207113164 Treacher Collins-Franceschetti syndrome 1 isoform f
           [Homo sapiens]
          Length = 1412

 Score = 37.7 bits (86), Expect = 0.020
 Identities = 54/228 (23%), Positives = 94/228 (41%), Gaps = 27/228 (11%)

Query: 125 APLTSQPERSSSQRARGKTPSSPTLSPSRGSPLLLREPSLVTDSLEA--HRPCPCPPQPN 182
           AP    P + ++    GKT   P ++ ++      RE    + S E+      P   +P+
Sbjct: 299 APAKESPRKGAAPAPPGKT--GPAVAKAQAGK---REEDSQSSSEESDSEEEAPAQAKPS 353

Query: 183 QLAPQL--SSAPAQLVWAETHSLALPRPNGPESLTWVIFRKSKDGRVHLASSSRLRLRRL 240
             APQ+  +SAPA+    +  + A PR  GP +    + ++ +D R   +S      R  
Sbjct: 354 GKAPQVRAASAPAKESPRKGAAPAPPRKTGPAAAQVQVGKQEEDSR--SSSEESDSDREA 411

Query: 241 LFPLSTQGCERHRSSPRRPPSAGVDVGLLLAQGRGVP----APASRSC-----ERDGRRL 291
           L  ++    +    SP+  P++ + +G L      VP     PA+ S      E D    
Sbjct: 412 LAAMNAAQVKPLGKSPQVKPASTMGMGPLGKGAGPVPPGKVGPATPSAQVGKWEEDSESS 471

Query: 292 VEGKQDSAEHQ------SGPEPALPSLLSTKPPLAEDGRGVAGEVGPV 333
            E   DS++ +         E +L ++L  K P +   +G   + GPV
Sbjct: 472 SEESSDSSDGEVPTAVAPAQEKSLGNILQAK-PTSSPAKGPPQKAGPV 518


>gi|207113162 Treacher Collins-Franceschetti syndrome 1 isoform e
           [Homo sapiens]
          Length = 1451

 Score = 37.7 bits (86), Expect = 0.020
 Identities = 54/228 (23%), Positives = 94/228 (41%), Gaps = 27/228 (11%)

Query: 125 APLTSQPERSSSQRARGKTPSSPTLSPSRGSPLLLREPSLVTDSLEA--HRPCPCPPQPN 182
           AP    P + ++    GKT   P ++ ++      RE    + S E+      P   +P+
Sbjct: 376 APAKESPRKGAAPAPPGKT--GPAVAKAQAGK---REEDSQSSSEESDSEEEAPAQAKPS 430

Query: 183 QLAPQL--SSAPAQLVWAETHSLALPRPNGPESLTWVIFRKSKDGRVHLASSSRLRLRRL 240
             APQ+  +SAPA+    +  + A PR  GP +    + ++ +D R   +S      R  
Sbjct: 431 GKAPQVRAASAPAKESPRKGAAPAPPRKTGPAAAQVQVGKQEEDSR--SSSEESDSDREA 488

Query: 241 LFPLSTQGCERHRSSPRRPPSAGVDVGLLLAQGRGVP----APASRSC-----ERDGRRL 291
           L  ++    +    SP+  P++ + +G L      VP     PA+ S      E D    
Sbjct: 489 LAAMNAAQVKPLGKSPQVKPASTMGMGPLGKGAGPVPPGKVGPATPSAQVGKWEEDSESS 548

Query: 292 VEGKQDSAEHQ------SGPEPALPSLLSTKPPLAEDGRGVAGEVGPV 333
            E   DS++ +         E +L ++L  K P +   +G   + GPV
Sbjct: 549 SEESSDSSDGEVPTAVAPAQEKSLGNILQAK-PTSSPAKGPPQKAGPV 595



 Score = 29.6 bits (65), Expect = 5.4
 Identities = 27/124 (21%), Positives = 47/124 (37%), Gaps = 14/124 (11%)

Query: 67  HQSTGRLLSCLPTRRGHSRSALQKNRLHCPTEGPTNQTPYIKGTEGNG--PGLGPQEEPP 124
           H +TG+ ++ L + +   +SA            P+  T  +  TE  G  P  G   +P 
Sbjct: 141 HPATGKTVANLLSGKSPRKSA-----------EPSANTTLVSETEEEGSVPAFGAAAKPG 189

Query: 125 APLTSQPERSSSQRARGKTPSSPTLSPSRGSPLLLREPSLVTDSLEAHRPCPCPPQPNQL 184
                Q + SS   +     +     PS   P  ++  S+ T    A +  P P +   +
Sbjct: 190 MVSAGQADSSSEDTSSSSDETDVEGKPSV-KPAQVKASSVSTKESPARKAAPAPGKVGDV 248

Query: 185 APQL 188
            PQ+
Sbjct: 249 TPQV 252


>gi|207113160 Treacher Collins-Franceschetti syndrome 1 isoform d
           [Homo sapiens]
          Length = 1488

 Score = 37.7 bits (86), Expect = 0.020
 Identities = 54/228 (23%), Positives = 94/228 (41%), Gaps = 27/228 (11%)

Query: 125 APLTSQPERSSSQRARGKTPSSPTLSPSRGSPLLLREPSLVTDSLEA--HRPCPCPPQPN 182
           AP    P + ++    GKT   P ++ ++      RE    + S E+      P   +P+
Sbjct: 376 APAKESPRKGAAPAPPGKT--GPAVAKAQAGK---REEDSQSSSEESDSEEEAPAQAKPS 430

Query: 183 QLAPQL--SSAPAQLVWAETHSLALPRPNGPESLTWVIFRKSKDGRVHLASSSRLRLRRL 240
             APQ+  +SAPA+    +  + A PR  GP +    + ++ +D R   +S      R  
Sbjct: 431 GKAPQVRAASAPAKESPRKGAAPAPPRKTGPAAAQVQVGKQEEDSR--SSSEESDSDREA 488

Query: 241 LFPLSTQGCERHRSSPRRPPSAGVDVGLLLAQGRGVP----APASRSC-----ERDGRRL 291
           L  ++    +    SP+  P++ + +G L      VP     PA+ S      E D    
Sbjct: 489 LAAMNAAQVKPLGKSPQVKPASTMGMGPLGKGAGPVPPGKVGPATPSAQVGKWEEDSESS 548

Query: 292 VEGKQDSAEHQ------SGPEPALPSLLSTKPPLAEDGRGVAGEVGPV 333
            E   DS++ +         E +L ++L  K P +   +G   + GPV
Sbjct: 549 SEESSDSSDGEVPTAVAPAQEKSLGNILQAK-PTSSPAKGPPQKAGPV 595



 Score = 29.6 bits (65), Expect = 5.4
 Identities = 27/124 (21%), Positives = 47/124 (37%), Gaps = 14/124 (11%)

Query: 67  HQSTGRLLSCLPTRRGHSRSALQKNRLHCPTEGPTNQTPYIKGTEGNG--PGLGPQEEPP 124
           H +TG+ ++ L + +   +SA            P+  T  +  TE  G  P  G   +P 
Sbjct: 141 HPATGKTVANLLSGKSPRKSA-----------EPSANTTLVSETEEEGSVPAFGAAAKPG 189

Query: 125 APLTSQPERSSSQRARGKTPSSPTLSPSRGSPLLLREPSLVTDSLEAHRPCPCPPQPNQL 184
                Q + SS   +     +     PS   P  ++  S+ T    A +  P P +   +
Sbjct: 190 MVSAGQADSSSEDTSSSSDETDVEGKPSV-KPAQVKASSVSTKESPARKAAPAPGKVGDV 248

Query: 185 APQL 188
            PQ+
Sbjct: 249 TPQV 252


>gi|57164975 Treacher Collins-Franceschetti syndrome 1 isoform b
           [Homo sapiens]
          Length = 1411

 Score = 37.7 bits (86), Expect = 0.020
 Identities = 54/228 (23%), Positives = 94/228 (41%), Gaps = 27/228 (11%)

Query: 125 APLTSQPERSSSQRARGKTPSSPTLSPSRGSPLLLREPSLVTDSLEA--HRPCPCPPQPN 182
           AP    P + ++    GKT   P ++ ++      RE    + S E+      P   +P+
Sbjct: 299 APAKESPRKGAAPAPPGKT--GPAVAKAQAGK---REEDSQSSSEESDSEEEAPAQAKPS 353

Query: 183 QLAPQL--SSAPAQLVWAETHSLALPRPNGPESLTWVIFRKSKDGRVHLASSSRLRLRRL 240
             APQ+  +SAPA+    +  + A PR  GP +    + ++ +D R   +S      R  
Sbjct: 354 GKAPQVRAASAPAKESPRKGAAPAPPRKTGPAAAQVQVGKQEEDSR--SSSEESDSDREA 411

Query: 241 LFPLSTQGCERHRSSPRRPPSAGVDVGLLLAQGRGVP----APASRSC-----ERDGRRL 291
           L  ++    +    SP+  P++ + +G L      VP     PA+ S      E D    
Sbjct: 412 LAAMNAAQVKPLGKSPQVKPASTMGMGPLGKGAGPVPPGKVGPATPSAQVGKWEEDSESS 471

Query: 292 VEGKQDSAEHQ------SGPEPALPSLLSTKPPLAEDGRGVAGEVGPV 333
            E   DS++ +         E +L ++L  K P +   +G   + GPV
Sbjct: 472 SEESSDSSDGEVPTAVAPAQEKSLGNILQAK-PTSSPAKGPPQKAGPV 518


>gi|57164977 Treacher Collins-Franceschetti syndrome 1 isoform a
           [Homo sapiens]
          Length = 1450

 Score = 37.7 bits (86), Expect = 0.020
 Identities = 54/228 (23%), Positives = 94/228 (41%), Gaps = 27/228 (11%)

Query: 125 APLTSQPERSSSQRARGKTPSSPTLSPSRGSPLLLREPSLVTDSLEA--HRPCPCPPQPN 182
           AP    P + ++    GKT   P ++ ++      RE    + S E+      P   +P+
Sbjct: 376 APAKESPRKGAAPAPPGKT--GPAVAKAQAGK---REEDSQSSSEESDSEEEAPAQAKPS 430

Query: 183 QLAPQL--SSAPAQLVWAETHSLALPRPNGPESLTWVIFRKSKDGRVHLASSSRLRLRRL 240
             APQ+  +SAPA+    +  + A PR  GP +    + ++ +D R   +S      R  
Sbjct: 431 GKAPQVRAASAPAKESPRKGAAPAPPRKTGPAAAQVQVGKQEEDSR--SSSEESDSDREA 488

Query: 241 LFPLSTQGCERHRSSPRRPPSAGVDVGLLLAQGRGVP----APASRSC-----ERDGRRL 291
           L  ++    +    SP+  P++ + +G L      VP     PA+ S      E D    
Sbjct: 489 LAAMNAAQVKPLGKSPQVKPASTMGMGPLGKGAGPVPPGKVGPATPSAQVGKWEEDSESS 548

Query: 292 VEGKQDSAEHQ------SGPEPALPSLLSTKPPLAEDGRGVAGEVGPV 333
            E   DS++ +         E +L ++L  K P +   +G   + GPV
Sbjct: 549 SEESSDSSDGEVPTAVAPAQEKSLGNILQAK-PTSSPAKGPPQKAGPV 595



 Score = 29.6 bits (65), Expect = 5.4
 Identities = 27/124 (21%), Positives = 47/124 (37%), Gaps = 14/124 (11%)

Query: 67  HQSTGRLLSCLPTRRGHSRSALQKNRLHCPTEGPTNQTPYIKGTEGNG--PGLGPQEEPP 124
           H +TG+ ++ L + +   +SA            P+  T  +  TE  G  P  G   +P 
Sbjct: 141 HPATGKTVANLLSGKSPRKSA-----------EPSANTTLVSETEEEGSVPAFGAAAKPG 189

Query: 125 APLTSQPERSSSQRARGKTPSSPTLSPSRGSPLLLREPSLVTDSLEAHRPCPCPPQPNQL 184
                Q + SS   +     +     PS   P  ++  S+ T    A +  P P +   +
Sbjct: 190 MVSAGQADSSSEDTSSSSDETDVEGKPSV-KPAQVKASSVSTKESPARKAAPAPGKVGDV 248

Query: 185 APQL 188
            PQ+
Sbjct: 249 TPQV 252


>gi|57164979 Treacher Collins-Franceschetti syndrome 1 isoform c
           [Homo sapiens]
          Length = 958

 Score = 37.7 bits (86), Expect = 0.020
 Identities = 54/228 (23%), Positives = 94/228 (41%), Gaps = 27/228 (11%)

Query: 125 APLTSQPERSSSQRARGKTPSSPTLSPSRGSPLLLREPSLVTDSLEA--HRPCPCPPQPN 182
           AP    P + ++    GKT   P ++ ++      RE    + S E+      P   +P+
Sbjct: 376 APAKESPRKGAAPAPPGKT--GPAVAKAQAGK---REEDSQSSSEESDSEEEAPAQAKPS 430

Query: 183 QLAPQL--SSAPAQLVWAETHSLALPRPNGPESLTWVIFRKSKDGRVHLASSSRLRLRRL 240
             APQ+  +SAPA+    +  + A PR  GP +    + ++ +D R   +S      R  
Sbjct: 431 GKAPQVRAASAPAKESPRKGAAPAPPRKTGPAAAQVQVGKQEEDSR--SSSEESDSDREA 488

Query: 241 LFPLSTQGCERHRSSPRRPPSAGVDVGLLLAQGRGVP----APASRSC-----ERDGRRL 291
           L  ++    +    SP+  P++ + +G L      VP     PA+ S      E D    
Sbjct: 489 LAAMNAAQVKPLGKSPQVKPASTMGMGPLGKGAGPVPPGKVGPATPSAQVGKWEEDSESS 548

Query: 292 VEGKQDSAEHQ------SGPEPALPSLLSTKPPLAEDGRGVAGEVGPV 333
            E   DS++ +         E +L ++L  K P +   +G   + GPV
Sbjct: 549 SEESSDSSDGEVPTAVAPAQEKSLGNILQAK-PTSSPAKGPPQKAGPV 595



 Score = 29.6 bits (65), Expect = 5.4
 Identities = 27/124 (21%), Positives = 47/124 (37%), Gaps = 14/124 (11%)

Query: 67  HQSTGRLLSCLPTRRGHSRSALQKNRLHCPTEGPTNQTPYIKGTEGNG--PGLGPQEEPP 124
           H +TG+ ++ L + +   +SA            P+  T  +  TE  G  P  G   +P 
Sbjct: 141 HPATGKTVANLLSGKSPRKSA-----------EPSANTTLVSETEEEGSVPAFGAAAKPG 189

Query: 125 APLTSQPERSSSQRARGKTPSSPTLSPSRGSPLLLREPSLVTDSLEAHRPCPCPPQPNQL 184
                Q + SS   +     +     PS   P  ++  S+ T    A +  P P +   +
Sbjct: 190 MVSAGQADSSSEDTSSSSDETDVEGKPSV-KPAQVKASSVSTKESPARKAAPAPGKVGDV 248

Query: 185 APQL 188
            PQ+
Sbjct: 249 TPQV 252


>gi|50345997 E1A binding protein p300 [Homo sapiens]
          Length = 2414

 Score = 37.4 bits (85), Expect = 0.026
 Identities = 31/121 (25%), Positives = 48/121 (39%), Gaps = 10/121 (8%)

Query: 100 PTNQTPYIKGTEGNGPGLGPQEEPPAPLTSQPERSSSQRARGKTPSSPTLSPSRGSPLLL 159
           P+NQ  ++  T+    G+     P AP + Q   S +Q +    P +  + P       +
Sbjct: 758 PSNQGQFLPQTQFPSQGMNVTNIPLAPSSGQAPVSQAQMSSSSCPVNSPIMPPGSQGSHI 817

Query: 160 REPSLVTDSLEAHRPCPCP---PQPNQLAPQLSSAPAQLVWAETHSLALP----RPNGPE 212
             P L   +L  + P P P   P P+   P +    AQ   A T    +P     P GP+
Sbjct: 818 HCPQLPQPALHQNSPSPVPSRTPTPHHTPPSIG---AQQPPATTIPAPVPTPPAMPPGPQ 874

Query: 213 S 213
           S
Sbjct: 875 S 875


>gi|7662046 myeloid/lymphoid or mixed-lineage leukemia 4 [Homo
           sapiens]
          Length = 2715

 Score = 37.4 bits (85), Expect = 0.026
 Identities = 45/161 (27%), Positives = 62/161 (38%), Gaps = 23/161 (14%)

Query: 41  SPPFPKPRHWLSCTCGGEHENKELPLHQSTGRLLSC----LPTRRGHSRSALQKNRLHCP 96
           SPP P P    S   GG  E+      +ST  L +     +P     S   ++  R    
Sbjct: 493 SPPTPTP----STATGGPPEDSPTVAPKSTTFLKNIRQFIMPVVSARSSRVIKTPRRFMD 548

Query: 97  TEGP----TNQTPYIKGTEGNGPGLGPQEEPPAPLTSQPERSSSQRARGKTPSSPTLSPS 152
            + P       +P ++      P + PQE  PAP+ S P   +        PS+P   P 
Sbjct: 549 EDPPKPPKVEVSPVLRPPITTSPPV-PQE--PAPVPSPPRAPTP-------PSTPVPLPE 598

Query: 153 RGSPLLLREPSLVTDSLEAHRPCPCPPQPNQLAPQLSSAPA 193
           +   +L REP+    SL    P P P  P   AP    APA
Sbjct: 599 KRRSIL-REPTFRWTSLTRELPPPPPAPPPPPAPSPPPAPA 638



 Score = 32.0 bits (71), Expect = 1.1
 Identities = 34/112 (30%), Positives = 42/112 (37%), Gaps = 19/112 (16%)

Query: 100  PTNQTPYIKGTEG-NGPGLGPQEEPPAPLTSQ---------------PERSSSQRARGKT 143
            PT    ++ G  G     LGP  EPP P TS+                E         + 
Sbjct: 2159 PTRTFAWLPGAPGVRVLSLGPAPEPPKPATSKIILVNKLGQVFVKMAGEGEPVPPPVKQP 2218

Query: 144  PSSPTLSPSRGSPLLLREPSL--VTDSLEAHRPCPCPPQPNQLAPQLSSAPA 193
            P  PT+SP+  +   L    L  V   +   RP P PP P  L   LSS PA
Sbjct: 2219 PLPPTISPTAPTSWTLPPGPLLGVLPVVGVVRPAP-PPPPPPLTLVLSSGPA 2269



 Score = 31.2 bits (69), Expect = 1.9
 Identities = 29/75 (38%), Positives = 37/75 (49%), Gaps = 12/75 (16%)

Query: 109  GTEGNGPGLGPQEE--PPAPLTSQPERSSSQRARGKTPSSPTLSPSRGSPLLLREPSLVT 166
            G  G+G G GP+EE  PPAP    P  + SQ ++G T S     P+R    L   P +  
Sbjct: 2122 GGPGDG-GAGPREESLPPAP----PLANGSQPSQGLTAS--PADPTRTFAWLPGAPGVRV 2174

Query: 167  DSLEAHRPCPCPPQP 181
             SL    P P PP+P
Sbjct: 2175 LSL---GPAPEPPKP 2186



 Score = 29.3 bits (64), Expect = 7.1
 Identities = 49/196 (25%), Positives = 68/196 (34%), Gaps = 50/196 (25%)

Query: 15   HLPAVRTQLGGGAFHNEGPEFRGCVLSPPFPKPRHWLSCTCGGEHENKELPLHQSTGRLL 74
            H PA  ++  GG    E P     VL P  P+ RH          +N + PL   +G   
Sbjct: 1806 HSPAPSSEPPGG----EDPPLDTDVLVPGAPE-RH-------SPIQNLDPPLRPDSGSAP 1853

Query: 75   SCLPTRRGHSRSALQKNRLHCPTEGPTNQTPYIKGTEGNGPGLGPQEEPPAPLT------ 128
               P  R  S +     R+  P   P+ +          G   GP   P +P +      
Sbjct: 1854 P--PAPRSFSGA-----RIKVPNYSPSRRPL-------GGVSFGPLPSPGSPSSLTHHIP 1899

Query: 129  --SQPE-RSSSQRARGKTPSSPTLSPSR-GSPLLLREPSL--------------VTDSLE 170
                P+  +  +R+R  +P +P   PSR  SP L   P L               +  L 
Sbjct: 1900 TVGDPDFPAPPRRSRRPSPLAPRPPPSRWASPPLKTSPQLRVPPPTSVVTALTPTSGELA 1959

Query: 171  AHRPCPCPPQPNQLAP 186
               P P PP P  L P
Sbjct: 1960 PPGPAPSPPPPEDLGP 1975


>gi|19924099 synapsin I isoform Ia [Homo sapiens]
          Length = 705

 Score = 37.4 bits (85), Expect = 0.026
 Identities = 39/139 (28%), Positives = 54/139 (38%), Gaps = 16/139 (11%)

Query: 75  SCLPTRRGHSRSALQK--NRLHCPTEGPTNQTPYIKGTEGNGPGLGPQEEPPAPLTSQPE 132
           S LP R     SA Q+  ++   PT+G   Q+  + G    GPG  P   PPA  + Q +
Sbjct: 502 SPLPQRLPSPTSAPQQPASQAAPPTQGQGRQSRPVAG----GPGAPPAARPPASPSPQRQ 557

Query: 133 RSSSQRARGKTPSSPTLSPSRGSPLLLREPSLVTDSLEAHRPCPCPPQPNQLAPQLSSAP 192
               Q  R  + S P    + G+P     P          +P P P  P + A Q    P
Sbjct: 558 AGPPQATRQTSVSGPAPPKASGAP-----PGGQQRQGPPQKP-PGPAGPTRQASQAGPVP 611

Query: 193 AQLVWAETHSLALPRPNGP 211
                    +   PRP+GP
Sbjct: 612 R----TGPPTTQQPRPSGP 626


>gi|19924097 synapsin I isoform Ib [Homo sapiens]
          Length = 669

 Score = 37.4 bits (85), Expect = 0.026
 Identities = 39/139 (28%), Positives = 54/139 (38%), Gaps = 16/139 (11%)

Query: 75  SCLPTRRGHSRSALQK--NRLHCPTEGPTNQTPYIKGTEGNGPGLGPQEEPPAPLTSQPE 132
           S LP R     SA Q+  ++   PT+G   Q+  + G    GPG  P   PPA  + Q +
Sbjct: 502 SPLPQRLPSPTSAPQQPASQAAPPTQGQGRQSRPVAG----GPGAPPAARPPASPSPQRQ 557

Query: 133 RSSSQRARGKTPSSPTLSPSRGSPLLLREPSLVTDSLEAHRPCPCPPQPNQLAPQLSSAP 192
               Q  R  + S P    + G+P     P          +P P P  P + A Q    P
Sbjct: 558 AGPPQATRQTSVSGPAPPKASGAP-----PGGQQRQGPPQKP-PGPAGPTRQASQAGPVP 611

Query: 193 AQLVWAETHSLALPRPNGP 211
                    +   PRP+GP
Sbjct: 612 R----TGPPTTQQPRPSGP 626


>gi|148236531 hypothetical protein LOC339779 [Homo sapiens]
          Length = 412

 Score = 37.4 bits (85), Expect = 0.026
 Identities = 41/128 (32%), Positives = 53/128 (41%), Gaps = 31/128 (24%)

Query: 64  LPLHQSTGRLLSCLPTRRGHSRSALQKNRLHCPTEGPTNQTPYIKGTEGNGPGLGPQEEP 123
           L L Q   R L  LP +R                  P    P  K T+  G  L P  +P
Sbjct: 300 LRLPQGQARALHLLPEKR------------------PKEAGPQGKATQACGHQL-PASQP 340

Query: 124 PA------PLTSQPERSSSQRARG-KTPSSPTLSPSRGSPLLLREPSLVTDSLEAHRPCP 176
           PA      P+   P ++ S R+ G ++P+SP      G P   R P  VT SL+  RPCP
Sbjct: 341 PAAQARADPVPGTPSQTRSFRSAGLQSPNSPRC--FSGPP--PRAPKQVTTSLKP-RPCP 395

Query: 177 CPPQPNQL 184
            P +P  L
Sbjct: 396 GPKRPVSL 403



 Score = 29.3 bits (64), Expect = 7.1
 Identities = 22/71 (30%), Positives = 29/71 (40%), Gaps = 3/71 (4%)

Query: 123 PPAPLTSQPERSSSQRARGKTPSSPTLSPSRGSPLLLR-EPSLVTDSLEAHRPCPCPPQP 181
           P +P        S  R R  +PS+  L PS   PL     PS   +S   H PC  P  P
Sbjct: 92  PSSPTFFHQNYLSLPRPRASSPSNHWLYPS--PPLTPSFSPSQPQNSSLPHSPCQSPSHP 149

Query: 182 NQLAPQLSSAP 192
            +L     ++P
Sbjct: 150 EELHSSTLTSP 160


>gi|226437579 NAC alpha domain containing [Homo sapiens]
          Length = 1562

 Score = 37.0 bits (84), Expect = 0.034
 Identities = 65/262 (24%), Positives = 101/262 (38%), Gaps = 42/262 (16%)

Query: 114  GPGLGPQ---EEPPAPLTSQPERSSSQRARGKTPSSPTLSPSRGSPLLLREPSLVTDSLE 170
            G  LGP+   EE  A L + PE ++  + +   P     +   G+P   +E +  T  +E
Sbjct: 970  GEALGPRPAPEEKNAALPTVPEPAALDQVQQDDPQP---AAEAGTPWAAQEDADSTLGME 1026

Query: 171  A-HRPCPCPPQPNQLAPQLSSAPAQL-VWAETHSLALPRPNGPESLTWVIFRKSKDGRVH 228
            A   P P      ++A  LS    +  + A  H+    +P+ P+  T  +  + + G   
Sbjct: 1027 ALSLPEPASGAGEEIAEALSRPGREACLEARAHTGDGAKPDSPQKETLEVENQQEGGLKP 1086

Query: 229  LASSSRLRLRRLLFPLSTQGCERHRSSPRRPPSAGVDVGLLLAQGRGVPAPASRSCERDG 288
            LA            P S  G  R    P  PP+A  +V    +Q R + +PA        
Sbjct: 1087 LAQEHG--------PRSALGGARE--VPDAPPAACPEV----SQAR-LLSPAREE----- 1126

Query: 289  RRLVEGKQDSAEHQSGPEPALPSLLSTKPPLAEDGRGVAGEVGPVDHTALLGRTAPGLPC 348
             R + GK       S PEP LPS ++T+  L        G V  +D      R  P  P 
Sbjct: 1127 -RGLSGK-------STPEPTLPSAVATEASLDSCPESSVGAVSSLD------RGCPDAPA 1172

Query: 349  RVALPPLSHRLLETGVQTLELP 370
              + P         G+ ++E P
Sbjct: 1173 PTSAPTSQQPEPVLGLGSVEQP 1194


  Database: hs.faa
    Posted date:  Aug 4, 2009  4:42 PM
  Number of letters in database: 18,247,518
  Number of sequences in database:  37,866
  
Lambda     K      H
   0.315    0.134    0.415 

Gapped
Lambda     K      H
   0.267   0.0410    0.140 


Matrix: BLOSUM62
Gap Penalties: Existence: 11, Extension: 1
Number of Hits to DB: 22,694,893
Number of Sequences: 37866
Number of extensions: 1436975
Number of successful extensions: 6771
Number of sequences better than 10.0: 30
Number of HSP's better than 10.0 without gapping: 49
Number of HSP's successfully gapped in prelim test: 553
Number of HSP's that attempted gapping in prelim test: 5740
Number of HSP's gapped (non-prelim): 1494
length of query: 424
length of database: 18,247,518
effective HSP length: 105
effective length of query: 319
effective length of database: 14,271,588
effective search space: 4552636572
effective search space used: 4552636572
T: 11
A: 40
X1: 16 ( 7.3 bits)
X2: 38 (14.6 bits)
X3: 64 (24.7 bits)
S1: 42 (22.0 bits)
S2: 63 (28.9 bits)

Search results were obtained with NCBI BLAST and RefSeq entries.


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Guide to the Human Genome
Copyright © 2010 by Stewart Scherer. All rights reserved.

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