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Search of human proteins with 116256471
BLASTP 2.2.11 [Jun-05-2005]
Reference: Altschul, Stephen F., Thomas L. Madden, Alejandro A. Schaffer,
Jinghui Zhang, Zheng Zhang, Webb Miller, and David J. Lipman (1997),
"Gapped BLAST and PSI-BLAST: a new generation of protein database search
programs", Nucleic Acids Res. 25:3389-3402.
Query= gi|116256471 SNF1-like kinase [Homo sapiens]
(783 letters)
Database: hs.faa
37,866 sequences; 18,247,518 total letters
Searching..................................................done
Score E
Sequences producing significant alignments: (bits) Value
gi|116256471 SNF1-like kinase [Homo sapiens] 1580 0.0
gi|38569460 SNF1-like kinase 2 [Homo sapiens] 588 e-168
gi|38569491 serine/threonine-protein kinase QSK [Homo sapiens] 409 e-114
gi|153791472 MAP/microtubule affinity-regulating kinase 1 [Homo ... 363 e-100
gi|254028240 MAP/microtubule affinity-regulating kinase 2 isofor... 360 2e-99
gi|254028237 MAP/microtubule affinity-regulating kinase 2 isofor... 360 2e-99
gi|254028234 MAP/microtubule affinity-regulating kinase 2 isofor... 360 2e-99
gi|254028232 MAP/microtubule affinity-regulating kinase 2 isofor... 360 2e-99
gi|86990441 MAP/microtubule affinity-regulating kinase 2 isoform... 360 2e-99
gi|33636756 MAP/microtubule affinity-regulating kinase 4 [Homo s... 356 4e-98
gi|193083129 MAP/microtubule affinity-regulating kinase 3 isofor... 352 8e-97
gi|193083127 MAP/microtubule affinity-regulating kinase 3 isofor... 350 2e-96
gi|193083125 MAP/microtubule affinity-regulating kinase 3 isofor... 350 2e-96
gi|46852166 MAP/microtubule affinity-regulating kinase 3 isoform... 350 2e-96
gi|24308326 BR serine/threonine kinase 1 [Homo sapiens] 290 3e-78
gi|116089335 BR serine/threonine kinase 2 [Homo sapiens] 288 2e-77
gi|156105707 SNF related kinase [Homo sapiens] 286 5e-77
gi|156105705 SNF related kinase [Homo sapiens] 286 5e-77
gi|94557301 protein kinase, AMP-activated, alpha 1 catalytic sub... 280 3e-75
gi|46877068 AMP-activated protein kinase alpha 2 catalytic subun... 280 4e-75
gi|94557299 protein kinase, AMP-activated, alpha 1 catalytic sub... 270 3e-72
gi|23503303 serine/threonine-protein kinase NIM1 [Homo sapiens] 254 2e-67
gi|7662170 AMPK-related protein kinase 5 [Homo sapiens] 247 3e-65
gi|13569922 NUAK family, SNF1-like kinase, 2 [Homo sapiens] 239 9e-63
gi|7661974 maternal embryonic leucine zipper kinase [Homo sapiens] 228 2e-59
gi|14042947 testis-specific serine kinase 1 [Homo sapiens] 205 1e-52
gi|194294513 testis-specific serine kinase 2 [Homo sapiens] 197 4e-50
gi|7657214 hormonally upregulated Neu-associated kinase [Homo sa... 196 9e-50
gi|16418343 testis-specific serine kinase 3 [Homo sapiens] 185 2e-46
gi|149589021 doublecortin-like kinase 3 [Homo sapiens] 184 2e-46
>gi|116256471 SNF1-like kinase [Homo sapiens]
Length = 783
Score = 1580 bits (4090), Expect = 0.0
Identities = 783/783 (100%), Positives = 783/783 (100%)
Query: 1 MVIMSEFSADPAGQGQGQQKPLRVGFYDIERTLGKGNFAVVKLARHRVTKTQVAIKIIDK 60
MVIMSEFSADPAGQGQGQQKPLRVGFYDIERTLGKGNFAVVKLARHRVTKTQVAIKIIDK
Sbjct: 1 MVIMSEFSADPAGQGQGQQKPLRVGFYDIERTLGKGNFAVVKLARHRVTKTQVAIKIIDK 60
Query: 61 TRLDSSNLEKIYREVQLMKLLNHPHIIKLYQVMETKDMLYIVTEFAKNGEMFDYLTSNGH 120
TRLDSSNLEKIYREVQLMKLLNHPHIIKLYQVMETKDMLYIVTEFAKNGEMFDYLTSNGH
Sbjct: 61 TRLDSSNLEKIYREVQLMKLLNHPHIIKLYQVMETKDMLYIVTEFAKNGEMFDYLTSNGH 120
Query: 121 LSENEARKKFWQILSAVEYCHDHHIVHRDLKTENLLLDGNMDIKLADFGFGNFYKSGEPL 180
LSENEARKKFWQILSAVEYCHDHHIVHRDLKTENLLLDGNMDIKLADFGFGNFYKSGEPL
Sbjct: 121 LSENEARKKFWQILSAVEYCHDHHIVHRDLKTENLLLDGNMDIKLADFGFGNFYKSGEPL 180
Query: 181 STWCGSPPYAAPEVFEGKEYEGPQLDIWSLGVVLYVLVCGSLPFDGPNLPTLRQRVLEGR 240
STWCGSPPYAAPEVFEGKEYEGPQLDIWSLGVVLYVLVCGSLPFDGPNLPTLRQRVLEGR
Sbjct: 181 STWCGSPPYAAPEVFEGKEYEGPQLDIWSLGVVLYVLVCGSLPFDGPNLPTLRQRVLEGR 240
Query: 241 FRIPFFMSQDCESLIRRMLVVDPARRITIAQIRQHRWMRAEPCLPGPACPAFSAHSYTSN 300
FRIPFFMSQDCESLIRRMLVVDPARRITIAQIRQHRWMRAEPCLPGPACPAFSAHSYTSN
Sbjct: 241 FRIPFFMSQDCESLIRRMLVVDPARRITIAQIRQHRWMRAEPCLPGPACPAFSAHSYTSN 300
Query: 301 LGDYDEQALGIMQTLGVDRQRTVESLQNSSYNHFAAIYYLLLERLKEYRNAQCARPGPAR 360
LGDYDEQALGIMQTLGVDRQRTVESLQNSSYNHFAAIYYLLLERLKEYRNAQCARPGPAR
Sbjct: 301 LGDYDEQALGIMQTLGVDRQRTVESLQNSSYNHFAAIYYLLLERLKEYRNAQCARPGPAR 360
Query: 361 QPRPRSSDLSGLEVPQEGLSTDPFRPALLCPQPQTLVQSVLQAEMDCELQSSLQWPLFFP 420
QPRPRSSDLSGLEVPQEGLSTDPFRPALLCPQPQTLVQSVLQAEMDCELQSSLQWPLFFP
Sbjct: 361 QPRPRSSDLSGLEVPQEGLSTDPFRPALLCPQPQTLVQSVLQAEMDCELQSSLQWPLFFP 420
Query: 421 VDASCSGVFRPRPVSPSSLLDTAISEEARQGPGLEEEQDTQESLPSSTGRRHTLAEVSTR 480
VDASCSGVFRPRPVSPSSLLDTAISEEARQGPGLEEEQDTQESLPSSTGRRHTLAEVSTR
Sbjct: 421 VDASCSGVFRPRPVSPSSLLDTAISEEARQGPGLEEEQDTQESLPSSTGRRHTLAEVSTR 480
Query: 481 LSPLTAPCIVVSPSTTASPAEGTSSDSCLTFSASKSPAGLSGTPATQGLLGACSPVRLAS 540
LSPLTAPCIVVSPSTTASPAEGTSSDSCLTFSASKSPAGLSGTPATQGLLGACSPVRLAS
Sbjct: 481 LSPLTAPCIVVSPSTTASPAEGTSSDSCLTFSASKSPAGLSGTPATQGLLGACSPVRLAS 540
Query: 541 PFLGSQSATPVLQAQGGLGGAVLLPVSFQEGRRASDTSLTQGLKAFRQQLRKTTRTKGFL 600
PFLGSQSATPVLQAQGGLGGAVLLPVSFQEGRRASDTSLTQGLKAFRQQLRKTTRTKGFL
Sbjct: 541 PFLGSQSATPVLQAQGGLGGAVLLPVSFQEGRRASDTSLTQGLKAFRQQLRKTTRTKGFL 600
Query: 601 GLNKIKGLARQVCQAPASRASRGGLSPFHAPAQSPGLHGGAAGSREGWSLLEEVLEQQRL 660
GLNKIKGLARQVCQAPASRASRGGLSPFHAPAQSPGLHGGAAGSREGWSLLEEVLEQQRL
Sbjct: 601 GLNKIKGLARQVCQAPASRASRGGLSPFHAPAQSPGLHGGAAGSREGWSLLEEVLEQQRL 660
Query: 661 LQLQHHPAAAPGCSQAPQPAPAPFVIAPCDGPGAAPLPSTLLTSGLPLLPPPLLQTGASP 720
LQLQHHPAAAPGCSQAPQPAPAPFVIAPCDGPGAAPLPSTLLTSGLPLLPPPLLQTGASP
Sbjct: 661 LQLQHHPAAAPGCSQAPQPAPAPFVIAPCDGPGAAPLPSTLLTSGLPLLPPPLLQTGASP 720
Query: 721 VASAAQLLDTHLHIGTGPTALPAVPPPRLARLAPGCEPLGLLQGDCEMEDLMPCSLGTFV 780
VASAAQLLDTHLHIGTGPTALPAVPPPRLARLAPGCEPLGLLQGDCEMEDLMPCSLGTFV
Sbjct: 721 VASAAQLLDTHLHIGTGPTALPAVPPPRLARLAPGCEPLGLLQGDCEMEDLMPCSLGTFV 780
Query: 781 LVQ 783
LVQ
Sbjct: 781 LVQ 783
>gi|38569460 SNF1-like kinase 2 [Homo sapiens]
Length = 926
Score = 588 bits (1516), Expect = e-168
Identities = 344/682 (50%), Positives = 442/682 (64%), Gaps = 49/682 (7%)
Query: 18 QQKPLRVGFYDIERTLGKGNFAVVKLARHRVTKTQVAIKIIDKTRLDSSNLEKIYREVQL 77
Q+ P+RVGFYDIE TLGKGNFAVVKL RHR+TKT+VAIKIIDK++LD+ NLEKIYREVQ+
Sbjct: 11 QRGPVRVGFYDIEGTLGKGNFAVVKLGRHRITKTEVAIKIIDKSQLDAVNLEKIYREVQI 70
Query: 78 MKLLNHPHIIKLYQVMETKDMLYIVTEFAKNGEMFDYLTSNGHLSENEARKKFWQILSAV 137
MK+L+HPHIIKLYQVMETK MLY+VTE+AKNGE+FDYL ++G L+E+EAR+KFWQILSAV
Sbjct: 71 MKMLDHPHIIKLYQVMETKSMLYLVTEYAKNGEIFDYLANHGRLNESEARRKFWQILSAV 130
Query: 138 EYCHDHHIVHRDLKTENLLLDGNMDIKLADFGFGNFYKSGEPLSTWCGSPPYAAPEVFEG 197
+YCH IVHRDLK ENLLLD NM+IK+ADFGFGNF+KSGE L+TWCGSPPYAAPEVFEG
Sbjct: 131 DYCHGRKIVHRDLKAENLLLDNNMNIKIADFGFGNFFKSGELLATWCGSPPYAAPEVFEG 190
Query: 198 KEYEGPQLDIWSLGVVLYVLVCGSLPFDGPNLPTLRQRVLEGRFRIPFFMSQDCESLIRR 257
++YEGPQLDIWS+GVVLYVLVCG+LPFDGP LP LRQRVLEGRFRIP+FMS+DCE LIRR
Sbjct: 191 QQYEGPQLDIWSMGVVLYVLVCGALPFDGPTLPILRQRVLEGRFRIPYFMSEDCEHLIRR 250
Query: 258 MLVVDPARRITIAQIRQHRWMRAEPCLPGPACPAFSAHSYTSNLGDYDEQALGIMQTLGV 317
MLV+DP++R+TIAQI++H+WM E + P + S +G+++EQ L +M +LG+
Sbjct: 251 MLVLDPSKRLTIAQIKEHKWMLIEVPVQRPVLYPQEQENEPS-IGEFNEQVLRLMHSLGI 309
Query: 318 DRQRTVESLQNSSYNHFAAIYYLLLERLKEYRNA---------QCARPGPARQPRPRSSD 368
D+Q+T+ESLQN SYNHFAAIY+LL+ERLK +R++ + RP + +
Sbjct: 310 DQQKTIESLQNKSYNHFAAIYFLLVERLKSHRSSFPVEQRLDGRQRRPSTIAEQTVAKAQ 369
Query: 369 LSGLEVPQEGLSTDPFRPALLCPQPQTLVQSVLQA----------EMDCELQSSLQWPLF 418
GL V + R ALL PQ + A E +C + L
Sbjct: 370 TVGLPVTMHSPNMRLLRSALL-PQASNVEAFSFPASGCQAEAAFMEEECVDTPKVNGCLL 428
Query: 419 FPVDASCSGVFRPRPVSPSSLLDTAISEEAR-QGPGLEEEQDTQESLPS--STGRRHTLA 475
PV V + PS++++T+I E +G E+ E+ S S RRHTL+
Sbjct: 429 DPVPPVL--VRKGCQSLPSNMMETSIDEGLETEGEAEEDPAHAFEAFQSTRSGQRRHTLS 486
Query: 476 EVSTRLSPLTAPCIVVSPSTTASPAEGTSSDSCLTFSASKSPAGLSGTPATQGLLGACSP 535
EV+ +L + + S + SP+ + S + L P+ + ++ A P
Sbjct: 487 EVTNQLVVMPGAGKIFSMND--SPSLDSVDSEYDMGSVQRDLNFLEDNPSLKDIMLANQP 544
Query: 536 -VRLASPFLGSQSATPVLQAQGGLGGAV--LLPVSFQEGRRASDTSLTQGLKAFRQQLRK 592
R+ SPF+ + P +QA V PVSF+EGRRASDTSLTQG+ AFRQ L+
Sbjct: 545 SPRMTSPFISLRPTNPAMQALSSQKREVHNRSPVSFREGRRASDTSLTQGIVAFRQHLQN 604
Query: 593 TTRTKGFLGLNKIKGLARQVCQAPASRASRGGLSPFHAPAQSPGLHGGAAGSREGWSLLE 652
RTKG L LNK++ L Q+ P + P APA +P L A+ + E
Sbjct: 605 LARTKGILELNKVQLLYEQI--GPEA-------DPNLAPA-APQLQDLASSCPQ-----E 649
Query: 653 EVLEQQR---LLQLQHHPAAAP 671
EV +QQ L HP +P
Sbjct: 650 EVSQQQESVSTLPASVHPQLSP 671
>gi|38569491 serine/threonine-protein kinase QSK [Homo sapiens]
Length = 1263
Score = 409 bits (1051), Expect = e-114
Identities = 194/334 (58%), Positives = 259/334 (77%), Gaps = 8/334 (2%)
Query: 21 PLRVGFYDIERTLGKGNFAVVKLARHRVTKTQVAIKIIDKTRLDSSNLEKIYREVQLMKL 80
P R+G+Y+I+RT+GKGNFAVVK A H VTK +VAIKIIDKT+LD NL+KI+REVQ+MK+
Sbjct: 2 PARIGYYEIDRTIGKGNFAVVKRATHLVTKAKVAIKIIDKTQLDEENLKKIFREVQIMKM 61
Query: 81 LNHPHIIKLYQVMETKDMLYIVTEFAKNGEMFDYLTSNGHLSENEARKKFWQILSAVEYC 140
L HPHII+LYQVMET+ M+Y+VTE+A GE+FD+L ++G ++E EAR+KF QI++AV +C
Sbjct: 62 LCHPHIIRLYQVMETERMIYLVTEYASGGEIFDHLVAHGRMAEKEARRKFKQIVTAVYFC 121
Query: 141 HDHHIVHRDLKTENLLLDGNMDIKLADFGFGNFYKSGEPLSTWCGSPPYAAPEVFEGKEY 200
H +IVHRDLK ENLLLD N++IK+ADFGF N + G+ L TWCGSPPYAAPE+FEGKEY
Sbjct: 122 HCRNIVHRDLKAENLLLDANLNIKIADFGFSNLFTPGQLLKTWCGSPPYAAPELFEGKEY 181
Query: 201 EGPQLDIWSLGVVLYVLVCGSLPFDGPNLPTLRQRVLEGRFRIPFFMSQDCESLIRRMLV 260
+GP++DIWSLGVVLYVLVCG+LPFDG L LR RVL G+FRIPFFMS +CE LIR MLV
Sbjct: 182 DGPKVDIWSLGVVLYVLVCGALPFDGSTLQNLRARVLSGKFRIPFFMSTECEHLIRHMLV 241
Query: 261 VDPARRITIAQIRQHRWMRAEPCLPG-----PACPAFSAHSYTSNLGDYDEQALGIMQTL 315
+DP +R+++ QI +H+WM+ P C L +E L M+ +
Sbjct: 242 LDPNKRLSMEQICKHKWMKLGDADPNFDRLIAECQQLKEERQVDPL---NEDVLLAMEDM 298
Query: 316 GVDRQRTVESLQNSSYNHFAAIYYLLLERLKEYR 349
G+D+++T++SL++ +Y+H++AIY LL +R K ++
Sbjct: 299 GLDKEQTLQSLRSDAYDHYSAIYSLLCDRHKRHK 332
>gi|153791472 MAP/microtubule affinity-regulating kinase 1 [Homo
sapiens]
Length = 795
Score = 363 bits (931), Expect = e-100
Identities = 177/348 (50%), Positives = 249/348 (71%), Gaps = 8/348 (2%)
Query: 24 VGFYDIERTLGKGNFAVVKLARHRVTKTQVAIKIIDKTRLDSSNLEKIYREVQLMKLLNH 83
+G Y +++T+GKGNFA VKLARH +T +VA+KIIDKT+L+ ++L+K++REV++MK+LNH
Sbjct: 57 IGNYRLQKTIGKGNFAKVKLARHVLTGREVAVKIIDKTQLNPTSLQKLFREVRIMKILNH 116
Query: 84 PHIIKLYQVMETKDMLYIVTEFAKNGEMFDYLTSNGHLSENEARKKFWQILSAVEYCHDH 143
P+I+KL++V+ET+ LY+V E+A GE+FDYL ++G + E EAR KF QI+SAV+YCH
Sbjct: 117 PNIVKLFEVIETEKTLYLVMEYASGGEVFDYLVAHGRMKEKEARAKFRQIVSAVQYCHQK 176
Query: 144 HIVHRDLKTENLLLDGNMDIKLADFGFGNFYKSGEPLSTWCGSPPYAAPEVFEGKEYEGP 203
+IVHRDLK ENLLLDG+M+IK+ADFGF N + G L T+CGSPPYAAPE+F+GK+Y+GP
Sbjct: 177 YIVHRDLKAENLLLDGDMNIKIADFGFSNEFTVGNKLDTFCGSPPYAAPELFQGKKYDGP 236
Query: 204 QLDIWSLGVVLYVLVCGSLPFDGPNLPTLRQRVLEGRFRIPFFMSQDCESLIRRMLVVDP 263
++D+WSLGV+LY LV GSLPFDG NL LR+RVL G++RIPF+MS DCE+L++++LV++P
Sbjct: 237 EVDVWSLGVILYTLVSGSLPFDGQNLKELRERVLRGKYRIPFYMSTDCENLLKKLLVLNP 296
Query: 264 ARRITIAQIRQHRWMRAEPCLPGPACPAFSAHSYTSNLGDY-DEQALGIMQTLGVDRQRT 322
+R ++ QI + RWM YT D+ D + + IM T+G R
Sbjct: 297 IKRGSLEQIMKDRWMNV-------GHEEEELKPYTEPDPDFNDTKRIDIMVTMGFARDEI 349
Query: 323 VESLQNSSYNHFAAIYYLLLERLKEYRNAQCARPGPARQPRPRSSDLS 370
++L N Y+ A Y LL + E+ + G Q SSDL+
Sbjct: 350 NDALINQKYDEVMATYILLGRKPPEFEGGESLSSGNLCQRSRPSSDLN 397
>gi|254028240 MAP/microtubule affinity-regulating kinase 2 isoform f
[Homo sapiens]
Length = 709
Score = 360 bits (925), Expect = 2e-99
Identities = 182/367 (49%), Positives = 255/367 (69%), Gaps = 20/367 (5%)
Query: 24 VGFYDIERTLGKGNFAVVKLARHRVTKTQVAIKIIDKTRLDSSNLEKIYREVQLMKLLNH 83
+G Y + +T+GKGNFA VKLARH +T +VA+KIIDKT+L+SS+L+K++REV++MK+LNH
Sbjct: 50 IGNYRLLKTIGKGNFAKVKLARHILTGKEVAVKIIDKTQLNSSSLQKLFREVRIMKVLNH 109
Query: 84 PHIIKLYQVMETKDMLYIVTEFAKNGEMFDYLTSNGHLSENEARKKFWQILSAVEYCHDH 143
P+I+KL++V+ET+ LY+V E+A GE+FDYL ++G + E EAR KF QI+SAV+YCH
Sbjct: 110 PNIVKLFEVIETEKTLYLVMEYASGGEVFDYLVAHGRMKEKEARAKFRQIVSAVQYCHQK 169
Query: 144 HIVHRDLKTENLLLDGNMDIKLADFGFGNFYKSGEPLSTWCGSPPYAAPEVFEGKEYEGP 203
IVHRDLK ENLLLD +M+IK+ADFGF N + G L T+CGSPPYAAPE+F+GK+Y+GP
Sbjct: 170 FIVHRDLKAENLLLDADMNIKIADFGFSNEFTFGNKLDTFCGSPPYAAPELFQGKKYDGP 229
Query: 204 QLDIWSLGVVLYVLVCGSLPFDGPNLPTLRQRVLEGRFRIPFFMSQDCESLIRRMLVVDP 263
++D+WSLGV+LY LV GSLPFDG NL LR+RVL G++RIPF+MS DCE+L+++ L+++P
Sbjct: 230 EVDVWSLGVILYTLVSGSLPFDGQNLKELRERVLRGKYRIPFYMSTDCENLLKKFLILNP 289
Query: 264 ARRITIAQIRQHRWMRAEPCLPGPACPAFSAHSYTSNLGDY-DEQALGIMQTLGVDRQRT 322
++R T+ QI + RWM Y L DY D + +M ++G R+
Sbjct: 290 SKRGTLEQIMKDRWMNV-------GHEDDELKPYVEPLPDYKDPRRTELMVSMGYTREEI 342
Query: 323 VESLQNSSYNHFAAIYYLLLERLKEYRNAQCARPGPARQPRPRSSDLSGLEVP------Q 376
+SL YN A Y LL Y++++ +PRP S+DL+ P Q
Sbjct: 343 QDSLVGQRYNEVMATYLLL-----GYKSSELEGDTITLKPRP-SADLTNSSAPSPSHKVQ 396
Query: 377 EGLSTDP 383
+S +P
Sbjct: 397 RSVSANP 403
>gi|254028237 MAP/microtubule affinity-regulating kinase 2 isoform e
[Homo sapiens]
Length = 719
Score = 360 bits (925), Expect = 2e-99
Identities = 182/367 (49%), Positives = 255/367 (69%), Gaps = 20/367 (5%)
Query: 24 VGFYDIERTLGKGNFAVVKLARHRVTKTQVAIKIIDKTRLDSSNLEKIYREVQLMKLLNH 83
+G Y + +T+GKGNFA VKLARH +T +VA+KIIDKT+L+SS+L+K++REV++MK+LNH
Sbjct: 50 IGNYRLLKTIGKGNFAKVKLARHILTGKEVAVKIIDKTQLNSSSLQKLFREVRIMKVLNH 109
Query: 84 PHIIKLYQVMETKDMLYIVTEFAKNGEMFDYLTSNGHLSENEARKKFWQILSAVEYCHDH 143
P+I+KL++V+ET+ LY+V E+A GE+FDYL ++G + E EAR KF QI+SAV+YCH
Sbjct: 110 PNIVKLFEVIETEKTLYLVMEYASGGEVFDYLVAHGRMKEKEARAKFRQIVSAVQYCHQK 169
Query: 144 HIVHRDLKTENLLLDGNMDIKLADFGFGNFYKSGEPLSTWCGSPPYAAPEVFEGKEYEGP 203
IVHRDLK ENLLLD +M+IK+ADFGF N + G L T+CGSPPYAAPE+F+GK+Y+GP
Sbjct: 170 FIVHRDLKAENLLLDADMNIKIADFGFSNEFTFGNKLDTFCGSPPYAAPELFQGKKYDGP 229
Query: 204 QLDIWSLGVVLYVLVCGSLPFDGPNLPTLRQRVLEGRFRIPFFMSQDCESLIRRMLVVDP 263
++D+WSLGV+LY LV GSLPFDG NL LR+RVL G++RIPF+MS DCE+L+++ L+++P
Sbjct: 230 EVDVWSLGVILYTLVSGSLPFDGQNLKELRERVLRGKYRIPFYMSTDCENLLKKFLILNP 289
Query: 264 ARRITIAQIRQHRWMRAEPCLPGPACPAFSAHSYTSNLGDY-DEQALGIMQTLGVDRQRT 322
++R T+ QI + RWM Y L DY D + +M ++G R+
Sbjct: 290 SKRGTLEQIMKDRWMNV-------GHEDDELKPYVEPLPDYKDPRRTELMVSMGYTREEI 342
Query: 323 VESLQNSSYNHFAAIYYLLLERLKEYRNAQCARPGPARQPRPRSSDLSGLEVP------Q 376
+SL YN A Y LL Y++++ +PRP S+DL+ P Q
Sbjct: 343 QDSLVGQRYNEVMATYLLL-----GYKSSELEGDTITLKPRP-SADLTNSSAPSPSHKVQ 396
Query: 377 EGLSTDP 383
+S +P
Sbjct: 397 RSVSANP 403
>gi|254028234 MAP/microtubule affinity-regulating kinase 2 isoform d
[Homo sapiens]
Length = 788
Score = 360 bits (925), Expect = 2e-99
Identities = 182/367 (49%), Positives = 255/367 (69%), Gaps = 20/367 (5%)
Query: 24 VGFYDIERTLGKGNFAVVKLARHRVTKTQVAIKIIDKTRLDSSNLEKIYREVQLMKLLNH 83
+G Y + +T+GKGNFA VKLARH +T +VA+KIIDKT+L+SS+L+K++REV++MK+LNH
Sbjct: 50 IGNYRLLKTIGKGNFAKVKLARHILTGKEVAVKIIDKTQLNSSSLQKLFREVRIMKVLNH 109
Query: 84 PHIIKLYQVMETKDMLYIVTEFAKNGEMFDYLTSNGHLSENEARKKFWQILSAVEYCHDH 143
P+I+KL++V+ET+ LY+V E+A GE+FDYL ++G + E EAR KF QI+SAV+YCH
Sbjct: 110 PNIVKLFEVIETEKTLYLVMEYASGGEVFDYLVAHGRMKEKEARAKFRQIVSAVQYCHQK 169
Query: 144 HIVHRDLKTENLLLDGNMDIKLADFGFGNFYKSGEPLSTWCGSPPYAAPEVFEGKEYEGP 203
IVHRDLK ENLLLD +M+IK+ADFGF N + G L T+CGSPPYAAPE+F+GK+Y+GP
Sbjct: 170 FIVHRDLKAENLLLDADMNIKIADFGFSNEFTFGNKLDTFCGSPPYAAPELFQGKKYDGP 229
Query: 204 QLDIWSLGVVLYVLVCGSLPFDGPNLPTLRQRVLEGRFRIPFFMSQDCESLIRRMLVVDP 263
++D+WSLGV+LY LV GSLPFDG NL LR+RVL G++RIPF+MS DCE+L+++ L+++P
Sbjct: 230 EVDVWSLGVILYTLVSGSLPFDGQNLKELRERVLRGKYRIPFYMSTDCENLLKKFLILNP 289
Query: 264 ARRITIAQIRQHRWMRAEPCLPGPACPAFSAHSYTSNLGDY-DEQALGIMQTLGVDRQRT 322
++R T+ QI + RWM Y L DY D + +M ++G R+
Sbjct: 290 SKRGTLEQIMKDRWMNV-------GHEDDELKPYVEPLPDYKDPRRTELMVSMGYTREEI 342
Query: 323 VESLQNSSYNHFAAIYYLLLERLKEYRNAQCARPGPARQPRPRSSDLSGLEVP------Q 376
+SL YN A Y LL Y++++ +PRP S+DL+ P Q
Sbjct: 343 QDSLVGQRYNEVMATYLLL-----GYKSSELEGDTITLKPRP-SADLTNSSAPSPSHKVQ 396
Query: 377 EGLSTDP 383
+S +P
Sbjct: 397 RSVSANP 403
>gi|254028232 MAP/microtubule affinity-regulating kinase 2 isoform c
[Homo sapiens]
Length = 724
Score = 360 bits (925), Expect = 2e-99
Identities = 182/367 (49%), Positives = 255/367 (69%), Gaps = 20/367 (5%)
Query: 24 VGFYDIERTLGKGNFAVVKLARHRVTKTQVAIKIIDKTRLDSSNLEKIYREVQLMKLLNH 83
+G Y + +T+GKGNFA VKLARH +T +VA+KIIDKT+L+SS+L+K++REV++MK+LNH
Sbjct: 50 IGNYRLLKTIGKGNFAKVKLARHILTGKEVAVKIIDKTQLNSSSLQKLFREVRIMKVLNH 109
Query: 84 PHIIKLYQVMETKDMLYIVTEFAKNGEMFDYLTSNGHLSENEARKKFWQILSAVEYCHDH 143
P+I+KL++V+ET+ LY+V E+A GE+FDYL ++G + E EAR KF QI+SAV+YCH
Sbjct: 110 PNIVKLFEVIETEKTLYLVMEYASGGEVFDYLVAHGRMKEKEARAKFRQIVSAVQYCHQK 169
Query: 144 HIVHRDLKTENLLLDGNMDIKLADFGFGNFYKSGEPLSTWCGSPPYAAPEVFEGKEYEGP 203
IVHRDLK ENLLLD +M+IK+ADFGF N + G L T+CGSPPYAAPE+F+GK+Y+GP
Sbjct: 170 FIVHRDLKAENLLLDADMNIKIADFGFSNEFTFGNKLDTFCGSPPYAAPELFQGKKYDGP 229
Query: 204 QLDIWSLGVVLYVLVCGSLPFDGPNLPTLRQRVLEGRFRIPFFMSQDCESLIRRMLVVDP 263
++D+WSLGV+LY LV GSLPFDG NL LR+RVL G++RIPF+MS DCE+L+++ L+++P
Sbjct: 230 EVDVWSLGVILYTLVSGSLPFDGQNLKELRERVLRGKYRIPFYMSTDCENLLKKFLILNP 289
Query: 264 ARRITIAQIRQHRWMRAEPCLPGPACPAFSAHSYTSNLGDY-DEQALGIMQTLGVDRQRT 322
++R T+ QI + RWM Y L DY D + +M ++G R+
Sbjct: 290 SKRGTLEQIMKDRWMNV-------GHEDDELKPYVEPLPDYKDPRRTELMVSMGYTREEI 342
Query: 323 VESLQNSSYNHFAAIYYLLLERLKEYRNAQCARPGPARQPRPRSSDLSGLEVP------Q 376
+SL YN A Y LL Y++++ +PRP S+DL+ P Q
Sbjct: 343 QDSLVGQRYNEVMATYLLL-----GYKSSELEGDTITLKPRP-SADLTNSSAPSPSHKVQ 396
Query: 377 EGLSTDP 383
+S +P
Sbjct: 397 RSVSANP 403
>gi|86990441 MAP/microtubule affinity-regulating kinase 2 isoform a
[Homo sapiens]
Length = 745
Score = 360 bits (925), Expect = 2e-99
Identities = 182/367 (49%), Positives = 255/367 (69%), Gaps = 20/367 (5%)
Query: 24 VGFYDIERTLGKGNFAVVKLARHRVTKTQVAIKIIDKTRLDSSNLEKIYREVQLMKLLNH 83
+G Y + +T+GKGNFA VKLARH +T +VA+KIIDKT+L+SS+L+K++REV++MK+LNH
Sbjct: 17 IGNYRLLKTIGKGNFAKVKLARHILTGKEVAVKIIDKTQLNSSSLQKLFREVRIMKVLNH 76
Query: 84 PHIIKLYQVMETKDMLYIVTEFAKNGEMFDYLTSNGHLSENEARKKFWQILSAVEYCHDH 143
P+I+KL++V+ET+ LY+V E+A GE+FDYL ++G + E EAR KF QI+SAV+YCH
Sbjct: 77 PNIVKLFEVIETEKTLYLVMEYASGGEVFDYLVAHGRMKEKEARAKFRQIVSAVQYCHQK 136
Query: 144 HIVHRDLKTENLLLDGNMDIKLADFGFGNFYKSGEPLSTWCGSPPYAAPEVFEGKEYEGP 203
IVHRDLK ENLLLD +M+IK+ADFGF N + G L T+CGSPPYAAPE+F+GK+Y+GP
Sbjct: 137 FIVHRDLKAENLLLDADMNIKIADFGFSNEFTFGNKLDTFCGSPPYAAPELFQGKKYDGP 196
Query: 204 QLDIWSLGVVLYVLVCGSLPFDGPNLPTLRQRVLEGRFRIPFFMSQDCESLIRRMLVVDP 263
++D+WSLGV+LY LV GSLPFDG NL LR+RVL G++RIPF+MS DCE+L+++ L+++P
Sbjct: 197 EVDVWSLGVILYTLVSGSLPFDGQNLKELRERVLRGKYRIPFYMSTDCENLLKKFLILNP 256
Query: 264 ARRITIAQIRQHRWMRAEPCLPGPACPAFSAHSYTSNLGDY-DEQALGIMQTLGVDRQRT 322
++R T+ QI + RWM Y L DY D + +M ++G R+
Sbjct: 257 SKRGTLEQIMKDRWMNV-------GHEDDELKPYVEPLPDYKDPRRTELMVSMGYTREEI 309
Query: 323 VESLQNSSYNHFAAIYYLLLERLKEYRNAQCARPGPARQPRPRSSDLSGLEVP------Q 376
+SL YN A Y LL Y++++ +PRP S+DL+ P Q
Sbjct: 310 QDSLVGQRYNEVMATYLLL-----GYKSSELEGDTITLKPRP-SADLTNSSAPSPSHKVQ 363
Query: 377 EGLSTDP 383
+S +P
Sbjct: 364 RSVSANP 370
>gi|33636756 MAP/microtubule affinity-regulating kinase 4 [Homo
sapiens]
Length = 688
Score = 356 bits (914), Expect = 4e-98
Identities = 176/325 (54%), Positives = 235/325 (72%), Gaps = 8/325 (2%)
Query: 24 VGFYDIERTLGKGNFAVVKLARHRVTKTQVAIKIIDKTRLDSSNLEKIYREVQLMKLLNH 83
VG Y + RT+GKGNFA VKLARH +T +VAIKIIDKT+L+ S+L+K++REV++MK LNH
Sbjct: 56 VGNYRLLRTIGKGNFAKVKLARHILTGREVAIKIIDKTQLNPSSLQKLFREVRIMKGLNH 115
Query: 84 PHIIKLYQVMETKDMLYIVTEFAKNGEMFDYLTSNGHLSENEARKKFWQILSAVEYCHDH 143
P+I+KL++V+ET+ LY+V E+A GE+FDYL S+G + E EAR KF QI+SAV YCH
Sbjct: 116 PNIVKLFEVIETEKTLYLVMEYASAGEVFDYLVSHGRMKEKEARAKFRQIVSAVHYCHQK 175
Query: 144 HIVHRDLKTENLLLDGNMDIKLADFGFGNFYKSGEPLSTWCGSPPYAAPEVFEGKEYEGP 203
+IVHRDLK ENLLLD +IK+ADFGF N + G L T+CGSPPYAAPE+F+GK+Y+GP
Sbjct: 176 NIVHRDLKAENLLLDAEANIKIADFGFSNEFTLGSKLDTFCGSPPYAAPELFQGKKYDGP 235
Query: 204 QLDIWSLGVVLYVLVCGSLPFDGPNLPTLRQRVLEGRFRIPFFMSQDCESLIRRMLVVDP 263
++DIWSLGV+LY LV GSLPFDG NL LR+RVL G++R+PF+MS DCES++RR LV++P
Sbjct: 236 EVDIWSLGVILYTLVSGSLPFDGHNLKELRERVLRGKYRVPFYMSTDCESILRRFLVLNP 295
Query: 264 ARRITIAQIRQHRWMRAEPCLPGPACPAFSAHSYTSNLGDY-DEQALGIMQTLGVDRQRT 322
A+R T+ QI + +W+ YT D+ D + + +M +G R+
Sbjct: 296 AKRCTLEQIMKDKWINI-------GYEGEELKPYTEPEEDFGDTKRIEVMVGMGYTREEI 348
Query: 323 VESLQNSSYNHFAAIYYLLLERLKE 347
ESL + YN A Y LL + +E
Sbjct: 349 KESLTSQKYNEVTATYLLLGRKTEE 373
>gi|193083129 MAP/microtubule affinity-regulating kinase 3 isoform d
[Homo sapiens]
Length = 713
Score = 352 bits (903), Expect = 8e-97
Identities = 173/329 (52%), Positives = 238/329 (72%), Gaps = 12/329 (3%)
Query: 24 VGFYDIERTLGKGNFAVVKLARHRVTKTQVAIKIIDKTRLDSSNLEKIYREVQLMKLLNH 83
+G Y + +T+GKGNFA VKLARH +T +VAIKIIDKT+L+ ++L+K++REV++MK+LNH
Sbjct: 53 IGNYRLLKTIGKGNFAKVKLARHILTGREVAIKIIDKTQLNPTSLQKLFREVRIMKILNH 112
Query: 84 PHIIKLYQVMETKDMLYIVTEFAKNGEMFDYLTSNGHLSENEARKKFWQILSAVEYCHDH 143
P+I+KL++V+ET+ LY++ E+A GE+FDYL ++G + E EAR KF QI+SAV+YCH
Sbjct: 113 PNIVKLFEVIETEKTLYLIMEYASGGEVFDYLVAHGRMKEKEARSKFRQIVSAVQYCHQK 172
Query: 144 HIVHRDLKTENLLLDGNMDIKLADFGFGNFYKSGEPLSTWCGSPPYAAPEVFEGKEYEGP 203
IVHRDLK ENLLLD +M+IK+ADFGF N + G L T+CGSPPYAAPE+F+GK+Y+GP
Sbjct: 173 RIVHRDLKAENLLLDADMNIKIADFGFSNEFTVGGKLDTFCGSPPYAAPELFQGKKYDGP 232
Query: 204 QLDIWSLGVVLYVLVCGSLPFDGPNLPTLRQRVLEGRFRIPFFMSQDCESLIRRMLVVDP 263
++D+WSLGV+LY LV GSLPFDG NL LR+RVL G++RIPF+MS DCE+L++R LV++P
Sbjct: 233 EVDVWSLGVILYTLVSGSLPFDGQNLKELRERVLRGKYRIPFYMSTDCENLLKRFLVLNP 292
Query: 264 ARRITIAQIRQHRWMRA---EPCLPGPACPAFSAHSYTSNLGDYDEQALGIMQTLGVDRQ 320
+R T+ QI + RW+ A E L P L D++ + IM +G ++
Sbjct: 293 IKRGTLEQIMKDRWINAGHEEDELKPFVEP---------ELDISDQKRIDIMVGMGYSQE 343
Query: 321 RTVESLQNSSYNHFAAIYYLLLERLKEYR 349
ESL Y+ A Y LL + E R
Sbjct: 344 EIQESLSKMKYDEITATYLLLGRKSSEVR 372
>gi|193083127 MAP/microtubule affinity-regulating kinase 3 isoform b
[Homo sapiens]
Length = 744
Score = 350 bits (899), Expect = 2e-96
Identities = 172/327 (52%), Positives = 237/327 (72%), Gaps = 12/327 (3%)
Query: 24 VGFYDIERTLGKGNFAVVKLARHRVTKTQVAIKIIDKTRLDSSNLEKIYREVQLMKLLNH 83
+G Y + +T+GKGNFA VKLARH +T +VAIKIIDKT+L+ ++L+K++REV++MK+LNH
Sbjct: 53 IGNYRLLKTIGKGNFAKVKLARHILTGREVAIKIIDKTQLNPTSLQKLFREVRIMKILNH 112
Query: 84 PHIIKLYQVMETKDMLYIVTEFAKNGEMFDYLTSNGHLSENEARKKFWQILSAVEYCHDH 143
P+I+KL++V+ET+ LY++ E+A GE+FDYL ++G + E EAR KF QI+SAV+YCH
Sbjct: 113 PNIVKLFEVIETEKTLYLIMEYASGGEVFDYLVAHGRMKEKEARSKFRQIVSAVQYCHQK 172
Query: 144 HIVHRDLKTENLLLDGNMDIKLADFGFGNFYKSGEPLSTWCGSPPYAAPEVFEGKEYEGP 203
IVHRDLK ENLLLD +M+IK+ADFGF N + G L T+CGSPPYAAPE+F+GK+Y+GP
Sbjct: 173 RIVHRDLKAENLLLDADMNIKIADFGFSNEFTVGGKLDTFCGSPPYAAPELFQGKKYDGP 232
Query: 204 QLDIWSLGVVLYVLVCGSLPFDGPNLPTLRQRVLEGRFRIPFFMSQDCESLIRRMLVVDP 263
++D+WSLGV+LY LV GSLPFDG NL LR+RVL G++RIPF+MS DCE+L++R LV++P
Sbjct: 233 EVDVWSLGVILYTLVSGSLPFDGQNLKELRERVLRGKYRIPFYMSTDCENLLKRFLVLNP 292
Query: 264 ARRITIAQIRQHRWMRA---EPCLPGPACPAFSAHSYTSNLGDYDEQALGIMQTLGVDRQ 320
+R T+ QI + RW+ A E L P L D++ + IM +G ++
Sbjct: 293 IKRGTLEQIMKDRWINAGHEEDELKPFVEP---------ELDISDQKRIDIMVGMGYSQE 343
Query: 321 RTVESLQNSSYNHFAAIYYLLLERLKE 347
ESL Y+ A Y LL + E
Sbjct: 344 EIQESLSKMKYDEITATYLLLGRKSSE 370
>gi|193083125 MAP/microtubule affinity-regulating kinase 3 isoform a
[Homo sapiens]
Length = 753
Score = 350 bits (899), Expect = 2e-96
Identities = 172/327 (52%), Positives = 237/327 (72%), Gaps = 12/327 (3%)
Query: 24 VGFYDIERTLGKGNFAVVKLARHRVTKTQVAIKIIDKTRLDSSNLEKIYREVQLMKLLNH 83
+G Y + +T+GKGNFA VKLARH +T +VAIKIIDKT+L+ ++L+K++REV++MK+LNH
Sbjct: 53 IGNYRLLKTIGKGNFAKVKLARHILTGREVAIKIIDKTQLNPTSLQKLFREVRIMKILNH 112
Query: 84 PHIIKLYQVMETKDMLYIVTEFAKNGEMFDYLTSNGHLSENEARKKFWQILSAVEYCHDH 143
P+I+KL++V+ET+ LY++ E+A GE+FDYL ++G + E EAR KF QI+SAV+YCH
Sbjct: 113 PNIVKLFEVIETEKTLYLIMEYASGGEVFDYLVAHGRMKEKEARSKFRQIVSAVQYCHQK 172
Query: 144 HIVHRDLKTENLLLDGNMDIKLADFGFGNFYKSGEPLSTWCGSPPYAAPEVFEGKEYEGP 203
IVHRDLK ENLLLD +M+IK+ADFGF N + G L T+CGSPPYAAPE+F+GK+Y+GP
Sbjct: 173 RIVHRDLKAENLLLDADMNIKIADFGFSNEFTVGGKLDTFCGSPPYAAPELFQGKKYDGP 232
Query: 204 QLDIWSLGVVLYVLVCGSLPFDGPNLPTLRQRVLEGRFRIPFFMSQDCESLIRRMLVVDP 263
++D+WSLGV+LY LV GSLPFDG NL LR+RVL G++RIPF+MS DCE+L++R LV++P
Sbjct: 233 EVDVWSLGVILYTLVSGSLPFDGQNLKELRERVLRGKYRIPFYMSTDCENLLKRFLVLNP 292
Query: 264 ARRITIAQIRQHRWMRA---EPCLPGPACPAFSAHSYTSNLGDYDEQALGIMQTLGVDRQ 320
+R T+ QI + RW+ A E L P L D++ + IM +G ++
Sbjct: 293 IKRGTLEQIMKDRWINAGHEEDELKPFVEP---------ELDISDQKRIDIMVGMGYSQE 343
Query: 321 RTVESLQNSSYNHFAAIYYLLLERLKE 347
ESL Y+ A Y LL + E
Sbjct: 344 EIQESLSKMKYDEITATYLLLGRKSSE 370
>gi|46852166 MAP/microtubule affinity-regulating kinase 3 isoform c
[Homo sapiens]
Length = 729
Score = 350 bits (899), Expect = 2e-96
Identities = 172/327 (52%), Positives = 237/327 (72%), Gaps = 12/327 (3%)
Query: 24 VGFYDIERTLGKGNFAVVKLARHRVTKTQVAIKIIDKTRLDSSNLEKIYREVQLMKLLNH 83
+G Y + +T+GKGNFA VKLARH +T +VAIKIIDKT+L+ ++L+K++REV++MK+LNH
Sbjct: 53 IGNYRLLKTIGKGNFAKVKLARHILTGREVAIKIIDKTQLNPTSLQKLFREVRIMKILNH 112
Query: 84 PHIIKLYQVMETKDMLYIVTEFAKNGEMFDYLTSNGHLSENEARKKFWQILSAVEYCHDH 143
P+I+KL++V+ET+ LY++ E+A GE+FDYL ++G + E EAR KF QI+SAV+YCH
Sbjct: 113 PNIVKLFEVIETEKTLYLIMEYASGGEVFDYLVAHGRMKEKEARSKFRQIVSAVQYCHQK 172
Query: 144 HIVHRDLKTENLLLDGNMDIKLADFGFGNFYKSGEPLSTWCGSPPYAAPEVFEGKEYEGP 203
IVHRDLK ENLLLD +M+IK+ADFGF N + G L T+CGSPPYAAPE+F+GK+Y+GP
Sbjct: 173 RIVHRDLKAENLLLDADMNIKIADFGFSNEFTVGGKLDTFCGSPPYAAPELFQGKKYDGP 232
Query: 204 QLDIWSLGVVLYVLVCGSLPFDGPNLPTLRQRVLEGRFRIPFFMSQDCESLIRRMLVVDP 263
++D+WSLGV+LY LV GSLPFDG NL LR+RVL G++RIPF+MS DCE+L++R LV++P
Sbjct: 233 EVDVWSLGVILYTLVSGSLPFDGQNLKELRERVLRGKYRIPFYMSTDCENLLKRFLVLNP 292
Query: 264 ARRITIAQIRQHRWMRA---EPCLPGPACPAFSAHSYTSNLGDYDEQALGIMQTLGVDRQ 320
+R T+ QI + RW+ A E L P L D++ + IM +G ++
Sbjct: 293 IKRGTLEQIMKDRWINAGHEEDELKPFVEP---------ELDISDQKRIDIMVGMGYSQE 343
Query: 321 RTVESLQNSSYNHFAAIYYLLLERLKE 347
ESL Y+ A Y LL + E
Sbjct: 344 EIQESLSKMKYDEITATYLLLGRKSSE 370
>gi|24308326 BR serine/threonine kinase 1 [Homo sapiens]
Length = 778
Score = 290 bits (743), Expect = 3e-78
Identities = 203/562 (36%), Positives = 283/562 (50%), Gaps = 69/562 (12%)
Query: 24 VGFYDIERTLGKGNFAVVKLARHRVTKTQVAIKIIDKTRLDSSNLEKIYREVQLMKLLNH 83
VG Y +E+TLGKG +VKL H +T +VAIKI+++ +L S L K+ RE+ ++KL+ H
Sbjct: 31 VGPYRLEKTLGKGQTGLVKLGVHCITGQKVAIKIVNREKLSESVLMKVEREIAILKLIEH 90
Query: 84 PHIIKLYQVMETKDMLYIVTEFAKNGEMFDYLTSNGHLSENEARKKFWQILSAVEYCHDH 143
PH++KL+ V E K LY+V E GE+FDYL G L+ EARK F QI+SA+++CH +
Sbjct: 91 PHVLKLHDVYENKKYLYLVLEHVSGGELFDYLVKKGRLTPKEARKFFRQIVSALDFCHSY 150
Query: 144 HIVHRDLKTENLLLDGNMDIKLADFGFGNFYKSGEPLSTWCGSPPYAAPEVFEGKEYEGP 203
I HRDLK ENLLLD +I++ADFG + L T CGSP YA PEV +G++Y+G
Sbjct: 151 SICHRDLKPENLLLDEKNNIRIADFGMASLQVGDSLLETSCGSPHYACPEVIKGEKYDGR 210
Query: 204 QLDIWSLGVVLYVLVCGSLPFDGPNLPTLRQRVLEGRFRIPFFMSQDCESLIRRMLVVDP 263
+ D+WS GV+L+ L+ G+LPFD NL L ++V G F +P F+ DC+SL+R M+ V+P
Sbjct: 211 RADMWSCGVILFALLVGALPFDDDNLRQLLEKVKRGVFHMPHFIPPDCQSLLRGMIEVEP 270
Query: 264 ARRITIAQIRQHRWM-----RAEPCLPGPACPAFSAHSYTSNLGDYDEQALGIMQTLGV- 317
+R+++ QI++H W +PCL + S SN G+ D L M +LG
Sbjct: 271 EKRLSLEQIQKHPWYLGGKHEPDPCLEPAPGRRVAMRSLPSN-GELDPDVLESMASLGCF 329
Query: 318 -DRQRTVESLQNSSYNHFAAIYYLLLERLKEYRNAQ---------------------CAR 355
DR+R L++ N IYYLLL+R + Y + + +R
Sbjct: 330 RDRERLHRELRSEEENQEKMIYYLLLDRKERYPSCEDQDLPPRNDVDPPRKRVDSPMLSR 389
Query: 356 PGPARQPRPRSSDLSGLEVPQEGLSTDPFRPALLCPQPQTLVQSVLQAEMDCELQSSLQW 415
G R+P +S ++ + G S P R AL Q +SV A L SS
Sbjct: 390 HG-KRRPERKSMEVLSITDAGGGGSPVPTRRALEMAQHSQRSRSVSGASTG--LSSS--- 443
Query: 416 PLFFPVDASCSGVFRPRPVSPSSLLDTAISEEARQGPGLEEEQDTQESL-PSSTGRRHTL 474
P+ + S VF P + +EAR G + T S P G
Sbjct: 444 ----PLSSPRSPVFSFSP-------EPGAGDEARGGGSPTSKTQTLPSRGPRGGGAGEQP 492
Query: 475 AEVSTRLSPLTAPCIVVSPSTTASPAEGTSSDSCLTFSASKSP-AGLSGTPATQ------ 527
S R +PL P P SS S +P A +GTP T
Sbjct: 493 PPPSARSTPLPGP-----------PGSPRSSGGTPLHSPLHTPRASPTGTPGTTPPPSPG 541
Query: 528 -GLLGACSPVRLAS---PFLGS 545
G+ GA RL S FLGS
Sbjct: 542 GGVGGAAWRSRLNSIRNSFLGS 563
>gi|116089335 BR serine/threonine kinase 2 [Homo sapiens]
Length = 668
Score = 288 bits (736), Expect = 2e-77
Identities = 151/340 (44%), Positives = 208/340 (61%), Gaps = 4/340 (1%)
Query: 13 GQGQGQQKPLRVGFYDIERTLGKGNFAVVKLARHRVTKTQVAIKIIDKTRLDSSNLEKIY 72
G+ G Q VG Y +E+TLGKG +VKL H VT +VAIKI+++ +L S L K+
Sbjct: 5 GKDGGAQHAQYVGPYRLEKTLGKGQTGLVKLGVHCVTCQKVAIKIVNREKLSESVLMKVE 64
Query: 73 REVQLMKLLNHPHIIKLYQVMETKDMLYIVTEFAKNGEMFDYLTSNGHLSENEARKKFWQ 132
RE+ ++KL+ HPH++KL+ V E K LY+V E GE+FDYL G L+ EARK F Q
Sbjct: 65 REIAILKLIEHPHVLKLHDVYENKKYLYLVLEHVSGGELFDYLVKKGRLTPKEARKFFRQ 124
Query: 133 ILSAVEYCHDHHIVHRDLKTENLLLDGNMDIKLADFGFGNFYKSGEPLSTWCGSPPYAAP 192
I+SA+++CH H I HRDLK ENLLLD +I++ADFG + L T CGSP YA P
Sbjct: 125 IISALDFCHSHSICHRDLKPENLLLDEKNNIRIADFGMASLQVGDSLLETSCGSPHYACP 184
Query: 193 EVFEGKEYEGPQLDIWSLGVVLYVLVCGSLPFDGPNLPTLRQRVLEGRFRIPFFMSQDCE 252
EV G++Y+G + D+WS GV+L+ L+ G+LPFD NL L ++V G F +P F+ DC+
Sbjct: 185 EVIRGEKYDGRKADVWSCGVILFALLVGALPFDDDNLRQLLEKVKRGVFHMPHFIPPDCQ 244
Query: 253 SLIRRMLVVDPARRITIAQIRQHRWMRAEPCLPGPACPAFSAHSYTS--NLGDYDEQALG 310
SL+R M+ VD ARR+T+ I++H W P P P S +L D D L
Sbjct: 245 SLLRGMIEVDAARRLTLEHIQKHIWYIGGKNEPEPEQPIPRKVQIRSLPSLEDIDPDVLD 304
Query: 311 IMQTLGV--DRQRTVESLQNSSYNHFAAIYYLLLERLKEY 348
M +LG DR + ++ L + N IY+LLL+R + Y
Sbjct: 305 SMHSLGCFRDRNKLLQDLLSEEENQEKMIYFLLLDRKERY 344
>gi|156105707 SNF related kinase [Homo sapiens]
Length = 765
Score = 286 bits (732), Expect = 5e-77
Identities = 170/476 (35%), Positives = 263/476 (55%), Gaps = 24/476 (5%)
Query: 25 GFYDIERTLGKGNFAVVKLARHRVTKTQVAIKIIDKTRLDSSNLEKIYREVQLMKLLNHP 84
G YD+++TLG+G+FAVVKLARH T +VA+K+IDKT+LD+ +++EV+ MKL+ HP
Sbjct: 14 GLYDLDKTLGRGHFAVVKLARHVFTGEKVAVKVIDKTKLDTLATGHLFQEVRCMKLVQHP 73
Query: 85 HIIKLYQVMETKDMLYIVTEFAKNGEMFDYLTSNGH-LSENEARKKFWQILSAVEYCHDH 143
+I++LY+V++T+ LY++ E G+MFDY+ + L+E+ A+K F QI+ A+ YCH
Sbjct: 74 NIVRLYEVIDTQTKLYLILELGDGGDMFDYIMKHEEGLNEDLAKKYFAQIVHAISYCHKL 133
Query: 144 HIVHRDLKTENLLLDGNMD-IKLADFGFGNFYKSGEPLSTWCGSPPYAAPEVFEGKEYEG 202
H+VHRDLK EN++ +KL DFGF N ++ G+ L+T CGS Y+APE+ G EY+
Sbjct: 134 HVVHRDLKPENVVFFEKQGLVKLTDFGFSNKFQPGKKLTTSCGSLAYSAPEILLGDEYDA 193
Query: 203 PQLDIWSLGVVLYVLVCGSLPFDGPNLPTLRQRVLEGRFRIPFFMSQDCESLIRRMLVVD 262
P +DIWSLGV+L++LVCG PF N +++ ++ +P +S++C+ LI RML D
Sbjct: 194 PAVDIWSLGVILFMLVCGQPPFQEANDSETLTMIMDCKYTVPSHVSKECKDLITRMLQRD 253
Query: 263 PARRITIAQIRQHRWMRAEPCLPGPACPAFSAHSYTSNLGDYDEQALGIMQTLG--VDRQ 320
P RR ++ +I H W++ P PA NL + + ++ LG DR
Sbjct: 254 PKRRASLEEIENHPWLQGVD--PSPATKYNIPLVSYKNLSEEEHNSIIQRMVLGDIADRD 311
Query: 321 RTVESLQNSSYNHFAAIYYLLLERL---KEYRNAQCARPGPAR-QPRPRSSDLSGLEVPQ 376
VE+L+ + YNH A Y+LL ER+ K+ + Q P+ + + R S + ++VPQ
Sbjct: 312 AIVEALETNRYNHITATYFLLAERILREKQEKEIQTRSASPSNIKAQFRQSWPTKIDVPQ 371
Query: 377 ---EGLSTDPFRPALLCPQPQTLVQSVLQAEMD---CELQSSLQWPLFFPVDASCSGVFR 430
+ L+ P A + P SVL C+ P S
Sbjct: 372 DLEDDLTATPLSHATVPQSPARAADSVLNGHRSKGLCDSAKKDDLPELAGPALS------ 425
Query: 431 PRPVSPSSLLDTAISEEARQGPGLEEEQDTQESLPSSTGRRHTLAEVSTRLSPLTA 486
V P+SL TA + +EE+D ++ P S + L + + LT+
Sbjct: 426 --TVPPASLKPTASGRKCLFRVEEDEEEDEEDKKPMSLSTQVVLRRKPSVTNRLTS 479
>gi|156105705 SNF related kinase [Homo sapiens]
Length = 765
Score = 286 bits (732), Expect = 5e-77
Identities = 170/476 (35%), Positives = 263/476 (55%), Gaps = 24/476 (5%)
Query: 25 GFYDIERTLGKGNFAVVKLARHRVTKTQVAIKIIDKTRLDSSNLEKIYREVQLMKLLNHP 84
G YD+++TLG+G+FAVVKLARH T +VA+K+IDKT+LD+ +++EV+ MKL+ HP
Sbjct: 14 GLYDLDKTLGRGHFAVVKLARHVFTGEKVAVKVIDKTKLDTLATGHLFQEVRCMKLVQHP 73
Query: 85 HIIKLYQVMETKDMLYIVTEFAKNGEMFDYLTSNGH-LSENEARKKFWQILSAVEYCHDH 143
+I++LY+V++T+ LY++ E G+MFDY+ + L+E+ A+K F QI+ A+ YCH
Sbjct: 74 NIVRLYEVIDTQTKLYLILELGDGGDMFDYIMKHEEGLNEDLAKKYFAQIVHAISYCHKL 133
Query: 144 HIVHRDLKTENLLLDGNMD-IKLADFGFGNFYKSGEPLSTWCGSPPYAAPEVFEGKEYEG 202
H+VHRDLK EN++ +KL DFGF N ++ G+ L+T CGS Y+APE+ G EY+
Sbjct: 134 HVVHRDLKPENVVFFEKQGLVKLTDFGFSNKFQPGKKLTTSCGSLAYSAPEILLGDEYDA 193
Query: 203 PQLDIWSLGVVLYVLVCGSLPFDGPNLPTLRQRVLEGRFRIPFFMSQDCESLIRRMLVVD 262
P +DIWSLGV+L++LVCG PF N +++ ++ +P +S++C+ LI RML D
Sbjct: 194 PAVDIWSLGVILFMLVCGQPPFQEANDSETLTMIMDCKYTVPSHVSKECKDLITRMLQRD 253
Query: 263 PARRITIAQIRQHRWMRAEPCLPGPACPAFSAHSYTSNLGDYDEQALGIMQTLG--VDRQ 320
P RR ++ +I H W++ P PA NL + + ++ LG DR
Sbjct: 254 PKRRASLEEIENHPWLQGVD--PSPATKYNIPLVSYKNLSEEEHNSIIQRMVLGDIADRD 311
Query: 321 RTVESLQNSSYNHFAAIYYLLLERL---KEYRNAQCARPGPAR-QPRPRSSDLSGLEVPQ 376
VE+L+ + YNH A Y+LL ER+ K+ + Q P+ + + R S + ++VPQ
Sbjct: 312 AIVEALETNRYNHITATYFLLAERILREKQEKEIQTRSASPSNIKAQFRQSWPTKIDVPQ 371
Query: 377 ---EGLSTDPFRPALLCPQPQTLVQSVLQAEMD---CELQSSLQWPLFFPVDASCSGVFR 430
+ L+ P A + P SVL C+ P S
Sbjct: 372 DLEDDLTATPLSHATVPQSPARAADSVLNGHRSKGLCDSAKKDDLPELAGPALS------ 425
Query: 431 PRPVSPSSLLDTAISEEARQGPGLEEEQDTQESLPSSTGRRHTLAEVSTRLSPLTA 486
V P+SL TA + +EE+D ++ P S + L + + LT+
Sbjct: 426 --TVPPASLKPTASGRKCLFRVEEDEEEDEEDKKPMSLSTQVVLRRKPSVTNRLTS 479
>gi|94557301 protein kinase, AMP-activated, alpha 1 catalytic
subunit isoform 1 [Homo sapiens]
Length = 559
Score = 280 bits (717), Expect = 3e-75
Identities = 143/333 (42%), Positives = 212/333 (63%), Gaps = 7/333 (2%)
Query: 22 LRVGFYDIERTLGKGNFAVVKLARHRVTKTQVAIKIIDKTRLDSSNLE-KIYREVQLMKL 80
+++G Y + TLG G F VK+ +H +T +VA+KI+++ ++ S ++ KI RE+Q +KL
Sbjct: 22 VKIGHYILGDTLGVGTFGKVKVGKHELTGHKVAVKILNRQKIRSLDVVGKIRREIQNLKL 81
Query: 81 LNHPHIIKLYQVMETKDMLYIVTEFAKNGEMFDYLTSNGHLSENEARKKFWQILSAVEYC 140
HPHIIKLYQV+ T +++V E+ GE+FDY+ NG L E E+R+ F QILS V+YC
Sbjct: 82 FRHPHIIKLYQVISTPSDIFMVMEYVSGGELFDYICKNGRLDEKESRRLFQQILSGVDYC 141
Query: 141 HDHHIVHRDLKTENLLLDGNMDIKLADFGFGNFYKSGEPLSTWCGSPPYAAPEVFEGKEY 200
H H +VHRDLK EN+LLD +M+ K+ADFG N GE L T CGSP YAAPEV G+ Y
Sbjct: 142 HRHMVVHRDLKPENVLLDAHMNAKIADFGLSNMMSDGEFLRTSCGSPNYAAPEVISGRLY 201
Query: 201 EGPQLDIWSLGVVLYVLVCGSLPFDGPNLPTLRQRVLEGRFRIPFFMSQDCESLIRRMLV 260
GP++DIWS GV+LY L+CG+LPFD ++PTL +++ +G F P +++ SL++ ML
Sbjct: 202 AGPEVDIWSSGVILYALLCGTLPFDDDHVPTLFKKICDGIFYTPQYLNPSVISLLKHMLQ 261
Query: 261 VDPARRITIAQIRQHRWMRAEPCLPGPACPAFSAHSYTSNLGDYDEQALGIMQTLGVDRQ 320
VDP +R TI IR+H W + + LP P SY+S + D DE + + +
Sbjct: 262 VDPMKRATIKDIREHEWFKQD--LPKYLFP--EDPSYSSTMID-DEALKEVCEKFECSEE 316
Query: 321 RTVESLQNSSY-NHFAAIYYLLLERLKEYRNAQ 352
+ L N ++ + A Y+L+++ + A+
Sbjct: 317 EVLSCLYNRNHQDPLAVAYHLIIDNRRIMNEAK 349
>gi|46877068 AMP-activated protein kinase alpha 2 catalytic subunit
[Homo sapiens]
Length = 552
Score = 280 bits (716), Expect = 4e-75
Identities = 154/375 (41%), Positives = 222/375 (59%), Gaps = 8/375 (2%)
Query: 22 LRVGFYDIERTLGKGNFAVVKLARHRVTKTQVAIKIIDKTRLDSSNLE-KIYREVQLMKL 80
+++G Y + TLG G F VK+ H++T +VA+KI+++ ++ S ++ KI RE+Q +KL
Sbjct: 11 VKIGHYVLGDTLGVGTFGKVKIGEHQLTGHKVAVKILNRQKIRSLDVVGKIKREIQNLKL 70
Query: 81 LNHPHIIKLYQVMETKDMLYIVTEFAKNGEMFDYLTSNGHLSENEARKKFWQILSAVEYC 140
HPHIIKLYQV+ T ++V E+ GE+FDY+ +G + E EAR+ F QILSAV+YC
Sbjct: 71 FRHPHIIKLYQVISTPTDFFMVMEYVSGGELFDYICKHGRVEEMEARRLFQQILSAVDYC 130
Query: 141 HDHHIVHRDLKTENLLLDGNMDIKLADFGFGNFYKSGEPLSTWCGSPPYAAPEVFEGKEY 200
H H +VHRDLK EN+LLD +M+ K+ADFG N GE L T CGSP YAAPEV G+ Y
Sbjct: 131 HRHMVVHRDLKPENVLLDAHMNAKIADFGLSNMMSDGEFLRTSCGSPNYAAPEVISGRLY 190
Query: 201 EGPQLDIWSLGVVLYVLVCGSLPFDGPNLPTLRQRVLEGRFRIPFFMSQDCESLIRRMLV 260
GP++DIWS GV+LY L+CG+LPFD ++PTL +++ G F IP ++++ +L+ ML
Sbjct: 191 AGPEVDIWSCGVILYALLCGTLPFDDEHVPTLFKKIRGGVFYIPEYLNRSVATLLMHMLQ 250
Query: 261 VDPARRITIAQIRQHRWMRAEPCLPGPACPAFSAHSYTSNLGDYDEQALGIMQTLGVDRQ 320
VDP +R TI IR+H W + + LP P SY +N+ D DE + +
Sbjct: 251 VDPLKRATIKDIREHEWFKQD--LPSYLFP--EDPSYDANVID-DEAVKEVCEKFECTES 305
Query: 321 RTVESLQNSSYNHFAAIYYLLLERLKEYRNAQCARPGPARQPRPRSSDLSGLEVPQEGLS 380
+ SL + A+ Y L+ + N + P D S + +P GL
Sbjct: 306 EVMNSLYSGDPQDQLAVAYHLIIDNRRIMNQASEFYLASSPPSGSFMDDSAMHIP-PGLK 364
Query: 381 TDPFR-PALLCPQPQ 394
P R P L+ P+
Sbjct: 365 PHPERMPPLIADSPK 379
>gi|94557299 protein kinase, AMP-activated, alpha 1 catalytic
subunit isoform 2 [Homo sapiens]
Length = 574
Score = 270 bits (691), Expect = 3e-72
Identities = 143/348 (41%), Positives = 212/348 (60%), Gaps = 22/348 (6%)
Query: 22 LRVGFYDIERTLGKGNFAVVKLARHRVTKTQVAIKIIDKTRLDSSNLE-KIYREVQLMKL 80
+++G Y + TLG G F VK+ +H +T +VA+KI+++ ++ S ++ KI RE+Q +KL
Sbjct: 22 VKIGHYILGDTLGVGTFGKVKVGKHELTGHKVAVKILNRQKIRSLDVVGKIRREIQNLKL 81
Query: 81 LNHPHIIKLYQVMETKDMLYIVTEFAKNGEMFDYLTSNGH---------------LSENE 125
HPHIIKLYQV+ T +++V E+ GE+FDY+ NG L E E
Sbjct: 82 FRHPHIIKLYQVISTPSDIFMVMEYVSGGELFDYICKNGRKSDVPGVVKTGSTKELDEKE 141
Query: 126 ARKKFWQILSAVEYCHDHHIVHRDLKTENLLLDGNMDIKLADFGFGNFYKSGEPLSTWCG 185
+R+ F QILS V+YCH H +VHRDLK EN+LLD +M+ K+ADFG N GE L T CG
Sbjct: 142 SRRLFQQILSGVDYCHRHMVVHRDLKPENVLLDAHMNAKIADFGLSNMMSDGEFLRTSCG 201
Query: 186 SPPYAAPEVFEGKEYEGPQLDIWSLGVVLYVLVCGSLPFDGPNLPTLRQRVLEGRFRIPF 245
SP YAAPEV G+ Y GP++DIWS GV+LY L+CG+LPFD ++PTL +++ +G F P
Sbjct: 202 SPNYAAPEVISGRLYAGPEVDIWSSGVILYALLCGTLPFDDDHVPTLFKKICDGIFYTPQ 261
Query: 246 FMSQDCESLIRRMLVVDPARRITIAQIRQHRWMRAEPCLPGPACPAFSAHSYTSNLGDYD 305
+++ SL++ ML VDP +R TI IR+H W + + LP P SY+S + D D
Sbjct: 262 YLNPSVISLLKHMLQVDPMKRATIKDIREHEWFKQD--LPKYLFP--EDPSYSSTMID-D 316
Query: 306 EQALGIMQTLGVDRQRTVESLQNSSY-NHFAAIYYLLLERLKEYRNAQ 352
E + + + + L N ++ + A Y+L+++ + A+
Sbjct: 317 EALKEVCEKFECSEEEVLSCLYNRNHQDPLAVAYHLIIDNRRIMNEAK 364
>gi|23503303 serine/threonine-protein kinase NIM1 [Homo sapiens]
Length = 436
Score = 254 bits (650), Expect = 2e-67
Identities = 137/352 (38%), Positives = 208/352 (59%), Gaps = 10/352 (2%)
Query: 23 RVGFYDIERTLGKGNFAVVKLARHRVTKTQVAIKIIDKTRLDSSNLEKIYREVQLMKLLN 82
R+GFY I +G GNF+ VKL H +TK +VAIKI+DKT+LD + RE+ M+ L+
Sbjct: 70 RIGFYRIRGEIGSGNFSQVKLGIHSLTKEKVAIKILDKTKLDQKTQRLLSREISSMEKLH 129
Query: 83 HPHIIKLYQVMETKDMLYIVTEFAKNGEMFDYLTSNGHLSENEARKKFWQILSAVEYCHD 142
HP+II+LY+V+ET L++V E+A GE+F +++ G LSE E++ F QI+SAV++ H+
Sbjct: 130 HPNIIRLYEVVETLSKLHLVMEYAGGGELFGKISTEGKLSEPESKLIFSQIVSAVKHMHE 189
Query: 143 HHIVHRDLKTENLLLDGNMDIKLADFGFGNFYKSGEPLSTWCGSPPYAAPEVFEGKEYEG 202
+ I+HRDLK EN+ N +K+ DFGF K GE L+T+CGSPPYAAPE+F + Y G
Sbjct: 190 NQIIHRDLKAENVFYTSNTCVKVGDFGFSTVSKKGEMLNTFCGSPPYAAPELFRDEHYIG 249
Query: 203 PQLDIWSLGVVLYVLVCGSLPFDGPNLPTLRQRVLEGRFRIPFFMSQDCESLIRRMLVVD 262
+DIW+LGV+LY +V G++PF + L++ +LEG + +P +S+ C LIR +L
Sbjct: 250 IYVDIWALGVLLYFMVTGTMPFRAETVAKLKKSILEGTYSVPPHVSEPCHRLIRGVLQQI 309
Query: 263 PARRITIAQIRQHRWMRAEPCLPGPACPAFSAH----SYTSNLGDYDEQALGIMQTLGVD 318
P R I I WM+ P P P P F S TS L + + + ++ LG+
Sbjct: 310 PTERYGIDCIMNDEWMQGVP-YPTPLEP-FQLDPKHLSETSTLKEEENEVKSTLEHLGIT 367
Query: 319 RQRTVESLQNSSYNHFAAIYYLLLERLKEYRNAQCARPGPARQ-PRPRSSDL 369
+ + + + +Y ++L R++ + + P P P+ DL
Sbjct: 368 EEHIRNNQGRDARSSITGVYRIILHRVQRKKALESV---PVMMLPDPKERDL 416
>gi|7662170 AMPK-related protein kinase 5 [Homo sapiens]
Length = 661
Score = 247 bits (630), Expect = 3e-65
Identities = 121/253 (47%), Positives = 168/253 (66%), Gaps = 2/253 (0%)
Query: 27 YDIERTLGKGNFAVVKLARHRVTKTQVAIKIIDKTRL-DSSNLEKIYREVQLMKLLNHPH 85
Y+++ TLGKG + VK A R + VAIK I K ++ D ++ I RE+++M LNHPH
Sbjct: 55 YELQETLGKGTYGKVKRATERFSGRVVAIKSIRKDKIKDEQDMVHIRREIEIMSSLNHPH 114
Query: 86 IIKLYQVMETKDMLYIVTEFAKNGEMFDYLTSNGHLSENEARKKFWQILSAVEYCHDHHI 145
II +Y+V E KD + I+ E+A GE++DY++ LSE E R F QI+SAV YCH + +
Sbjct: 115 IISIYEVFENKDKIVIIMEYASKGELYDYISERRRLSERETRHFFRQIVSAVHYCHKNGV 174
Query: 146 VHRDLKTENLLLDGNMDIKLADFGFGNFYKSGEPLSTWCGSPPYAAPEVFEGKEYEGPQL 205
VHRDLK EN+LLD N +IK+ADFG N Y+ + L T+CGSP YA+PE+ G+ Y GP++
Sbjct: 175 VHRDLKLENILLDDNCNIKIADFGLSNLYQKDKFLQTFCGSPLYASPEIVNGRPYRGPEV 234
Query: 206 DIWSLGVVLYVLVCGSLPFDGPNLPTLRQRVLEGRFRIPFFMSQDCESLIRRMLVVDPAR 265
D W+LGV+LY LV G++PFDG + L +++ G +R P D LIR ML+V+P R
Sbjct: 235 DSWALGVLLYTLVYGTMPFDGFDHKNLIRQISSGEYREP-TQPSDARGLIRWMLMVNPDR 293
Query: 266 RITIAQIRQHRWM 278
R TI I H W+
Sbjct: 294 RATIEDIANHWWV 306
>gi|13569922 NUAK family, SNF1-like kinase, 2 [Homo sapiens]
Length = 628
Score = 239 bits (609), Expect = 9e-63
Identities = 121/253 (47%), Positives = 167/253 (66%), Gaps = 3/253 (1%)
Query: 27 YDIERTLGKGNFAVVKLARHRVTKTQVAIKIIDKTRL-DSSNLEKIYREVQLMKLLNHPH 85
Y+ TLGKG + VK AR + VAIK I K ++ D +L I RE+++M LNHPH
Sbjct: 53 YEFLETLGKGTYGKVKKARESSGRL-VAIKSIRKDKIKDEQDLMHIRREIEIMSSLNHPH 111
Query: 86 IIKLYQVMETKDMLYIVTEFAKNGEMFDYLTSNGHLSENEARKKFWQILSAVEYCHDHHI 145
II +++V E + IV E+A G+++DY++ LSE EAR F QI+SAV YCH + +
Sbjct: 112 IIAIHEVFENSSKIVIVMEYASRGDLYDYISERQQLSEREARHFFRQIVSAVHYCHQNRV 171
Query: 146 VHRDLKTENLLLDGNMDIKLADFGFGNFYKSGEPLSTWCGSPPYAAPEVFEGKEYEGPQL 205
VHRDLK EN+LLD N +IK+ADFG N Y G+ L T+CGSP YA+PE+ GK Y GP++
Sbjct: 172 VHRDLKLENILLDANGNIKIADFGLSNLYHQGKFLQTFCGSPLYASPEIVNGKPYTGPEV 231
Query: 206 DIWSLGVVLYVLVCGSLPFDGPNLPTLRQRVLEGRFRIPFFMSQDCESLIRRMLVVDPAR 265
D WSLGV+LY+LV G++PFDG + L +++ G +R P S C LIR +L+V+P R
Sbjct: 232 DSWSLGVLLYILVHGTMPFDGHDHKILVKQISNGAYREPPKPSDAC-GLIRWLLMVNPTR 290
Query: 266 RITIAQIRQHRWM 278
R T+ + H W+
Sbjct: 291 RATLEDVASHWWV 303
>gi|7661974 maternal embryonic leucine zipper kinase [Homo sapiens]
Length = 651
Score = 228 bits (581), Expect = 2e-59
Identities = 128/322 (39%), Positives = 190/322 (59%), Gaps = 11/322 (3%)
Query: 26 FYDIERTLGKGNFAVVKLARHRVTKTQVAIKIIDKTRLDSSNLEKIYREVQLMKLLNHPH 85
+Y++ T+G G FA VKLA H +T VAIKI+DK L S+L +I E++ +K L H H
Sbjct: 10 YYELHETIGTGGFAKVKLACHILTGEMVAIKIMDKNTL-GSDLPRIKTEIEALKNLRHQH 68
Query: 86 IIKLYQVMETKDMLYIVTEFAKNGEMFDYLTSNGHLSENEARKKFWQILSAVEYCHDHHI 145
I +LY V+ET + +++V E+ GE+FDY+ S LSE E R F QI+SAV Y H
Sbjct: 69 ICQLYHVLETANKIFMVLEYCPGGELFDYIISQDRLSEEETRVVFRQIVSAVAYVHSQGY 128
Query: 146 VHRDLKTENLLLDGNMDIKLADFGFGNFYKSGEP--LSTWCGSPPYAAPEVFEGKEYEGP 203
HRDLK ENLL D +KL DFG K + L T CGS YAAPE+ +GK Y G
Sbjct: 129 AHRDLKPENLLFDEYHKLKLIDFGLCAKPKGNKDYHLQTCCGSLAYAAPELIQGKSYLGS 188
Query: 204 QLDIWSLGVVLYVLVCGSLPFDGPNLPTLRQRVLEGRFRIPFFMSQDCESLIRRMLVVDP 263
+ D+WS+G++LYVL+CG LPFD N+ L ++++ G++ +P ++S L+++ML VDP
Sbjct: 189 EADVWSMGILLYVLMCGFLPFDDDNVMALYKKIMRGKYDVPKWLSPSSILLLQQMLQVDP 248
Query: 264 ARRITIAQIRQHRWMRAEPCLPGPACPAFSAHSYTSNLGDYDEQALGIMQTLGVDRQRTV 323
+RI++ + H W+ + P + + + +L D L + + ++T+
Sbjct: 249 KKRISMKNLLNHPWIMQDYNYP----VEWQSKNPFIHLDDDCVTELSVHHR---NNRQTM 301
Query: 324 ESLQNS-SYNHFAAIYYLLLER 344
E L + Y+H A Y LLL +
Sbjct: 302 EDLISLWQYDHLTATYLLLLAK 323
>gi|14042947 testis-specific serine kinase 1 [Homo sapiens]
Length = 367
Score = 205 bits (521), Expect = 1e-52
Identities = 112/256 (43%), Positives = 159/256 (62%), Gaps = 9/256 (3%)
Query: 33 LGKGNFAVVKLARHRVTKTQVAIKIIDKTRLDSSNLEKIY-REVQLMKLLNHPHIIKLYQ 91
LG+G++A VK A K VAIKIID+ + + LEK RE++++ +LNH IIK Y+
Sbjct: 18 LGEGSYAKVKSAYSERLKFNVAIKIIDRKKAPADFLEKFLPREIEILAMLNHCSIIKTYE 77
Query: 92 VMETKD-MLYIVTEFAKNGEMFDYLTSNGHLSENEARKKFWQILSAVEYCHDHHIVHRDL 150
+ ET +YIV E A G++ + + + G L E+EARKKF Q+ A++YCHD +VHRDL
Sbjct: 78 IFETSHGKVYIVMELAVQGDLLELIKTRGALHEDEARKKFHQLSLAIKYCHDLDVVHRDL 137
Query: 151 KTENLLLDGNMDIKLADFGFGNFYKSGEP-----LSTWCGSPPYAAPEVFEGKEYEGPQL 205
K +NLLLD + +IKL+DF F + T+CGSP YAAPEV +G Y+
Sbjct: 138 KCDNLLLDKDFNIKLSDFSFSKRCLRDDSGRMALSKTFCGSPAYAAPEVLQGIPYQPKVY 197
Query: 206 DIWSLGVVLYVLVCGSLPFDGPNLPTLRQRVLEGRFRIP--FFMSQDCESLIRRMLVVDP 263
DIWSLGV+LY++VCGS+P+D N+ + + E R P ++ +C+ LI ML D
Sbjct: 198 DIWSLGVILYIMVCGSMPYDDSNIKKMLRIQKEHRVNFPRSKHLTGECKDLIYHMLQPDV 257
Query: 264 ARRITIAQIRQHRWMR 279
RR+ I +I H WM+
Sbjct: 258 NRRLHIDEILSHCWMQ 273
>gi|194294513 testis-specific serine kinase 2 [Homo sapiens]
Length = 358
Score = 197 bits (500), Expect = 4e-50
Identities = 111/267 (41%), Positives = 163/267 (61%), Gaps = 9/267 (3%)
Query: 22 LRVGFYDIERTLGKGNFAVVKLARHRVTKTQVAIKIIDKTRLDSSNLEKIY-REVQLMKL 80
LR Y + LGKG++A VK A K VA+KIID+ + + +E+ RE+ ++
Sbjct: 7 LRKKGYIVGINLGKGSYAKVKSAYSERLKFNVAVKIIDRKKTPTDFVERFLPREMDILAT 66
Query: 81 LNHPHIIKLYQVMETKD-MLYIVTEFAKNGEMFDYLTSNGHLSENEARKKFWQILSAVEY 139
+NH IIK Y++ ET D +YI+ E G++ +++ G L E+ ARK F Q+ SAV+Y
Sbjct: 67 VNHGSIIKTYEIFETSDGRIYIIMELGVQGDLLEFIKCQGALHEDVARKMFRQLSSAVKY 126
Query: 140 CHDHHIVHRDLKTENLLLDGNMDIKLADFGFGNFY---KSGEPL--STWCGSPPYAAPEV 194
CHD IVHRDLK ENLLLD + +IKL+DFGF +G + T+CGS YAAPEV
Sbjct: 127 CHDLDIVHRDLKCENLLLDKDFNIKLSDFGFSKRCLRDSNGRIILSKTFCGSAAYAAPEV 186
Query: 195 FEGKEYEGPQLDIWSLGVVLYVLVCGSLPFDGPNLPTLRQRVLEGRFRIPFF--MSQDCE 252
+ Y+ DIWSLGV+LY++VCGS+P+D ++ + + E R P ++ +C+
Sbjct: 187 LQSIPYQPKVYDIWSLGVILYIMVCGSMPYDDSDIRKMLRIQKEHRVDFPRSKNLTCECK 246
Query: 253 SLIRRMLVVDPARRITIAQIRQHRWMR 279
LI RML D ++R+ I +I H W++
Sbjct: 247 DLIYRMLQPDVSQRLHIDEILSHSWLQ 273
>gi|7657214 hormonally upregulated Neu-associated kinase [Homo
sapiens]
Length = 714
Score = 196 bits (497), Expect = 9e-50
Identities = 120/335 (35%), Positives = 187/335 (55%), Gaps = 12/335 (3%)
Query: 23 RVGFYDI-ERTLGKGNFAVVKLARHRVTKTQVAIKIIDKTRL--DSSNLEKIYREVQLMK 79
RVG Y I R LG+G+FA V+ H +T +VAIK+IDK R D+ + + RE Q+ +
Sbjct: 57 RVGNYLIGSRKLGEGSFAKVREGLHVLTGEKVAIKVIDKKRAKKDTYVTKNLRREGQIQQ 116
Query: 80 LLNHPHIIKLYQVMETKDMLYIVTEFAKNGEMFDYLTSNGHLSENEARKKFWQILSAVEY 139
++ HP+I +L ++ET++ Y+V E G + + L E+EAR+ Q++SAVE+
Sbjct: 117 MIRHPNITQLLDILETENSYYLVMELCPGGNLMHKIYEKKRLEESEARRYIRQLISAVEH 176
Query: 140 CHDHHIVHRDLKTENLLLDGNMDIKLADFGFGN---FYKSGEPLSTWCGSPPYAAPEVFE 196
H +VHRDLK ENLLLD + +IKL DFG N +P ST CGSP YAAPE+
Sbjct: 177 LHRAGVVHRDLKIENLLLDEDNNIKLIDFGLSNCAGILGYSDPFSTQCGSPAYAAPELLA 236
Query: 197 GKEYEGPQLDIWSLGVVLYVLVCGSLPF--DGPNLPTLRQRVLEGRFR-IPFFMSQDCES 253
K+Y GP++D+WS+GV +Y ++ G+LPF + +L L Q++++ +P +S S
Sbjct: 237 RKKY-GPKIDVWSIGVNMYAMLTGTLPFTVEPFSLRALYQKMVDKEMNPLPTQLSTGAIS 295
Query: 254 LIRRMLVVDPARRITIAQIRQHRWMRAEPCLPGPACPAFSAHSYTSNLGDYDEQALGIMQ 313
+R +L DP +R I Q +RW+ P + +L L + +
Sbjct: 296 FLRSLLEPDPVKRPNIQQALANRWLNENYTGKVPCNVTYPNRISLEDLS--PSVVLHMTE 353
Query: 314 TLGVDRQRTVESLQNSSYNHFAAIYYLLLERLKEY 348
LG + ++ ++ H AIY+LL ++L+ Y
Sbjct: 354 KLGYKNSDVINTVLSNRACHILAIYFLLNKKLERY 388
>gi|16418343 testis-specific serine kinase 3 [Homo sapiens]
Length = 268
Score = 185 bits (469), Expect = 2e-46
Identities = 100/257 (38%), Positives = 163/257 (63%), Gaps = 6/257 (2%)
Query: 27 YDIERTLGKGNFAVVKLARHRVTKTQVAIKIIDKTRLDSSNLEKIY-REVQLMKLLNHPH 85
Y + +T+G+G ++ VK A + + +VAIK+IDK +++ RE+Q+++ L+H +
Sbjct: 10 YQLGKTIGEGTYSKVKEAFSKKHQRKVAIKVIDKMGGPEEFIQRFLPRELQIVRTLDHKN 69
Query: 86 IIKLYQVMETKD-MLYIVTEFAKNGEMFDYLTSNGHLSENEARKKFWQILSAVEYCHDHH 144
II++Y+++E+ D + +V E A+ G++FD + + G L E+ A+ F Q++ A+ YCH
Sbjct: 70 IIQVYEMLESADGKICLVMELAEGGDVFDCVLNGGPLPESRAKALFRQMVEAIRYCHGCG 129
Query: 145 IVHRDLKTENLLLDGNMDIKLADFGFGNFY-KSGEPLS-TWCGSPPYAAPEVFEGKEYEG 202
+ HRDLK EN LL G ++KL DFGF KS LS T+CGS YAAPEV +G ++
Sbjct: 130 VAHRDLKCENALLQG-FNLKLTDFGFAKVLPKSHRELSQTFCGSTAYAAPEVLQGIPHDS 188
Query: 203 PQLDIWSLGVVLYVLVCGSLPFDGPNLPTLRQRVLEG-RFRIPFFMSQDCESLIRRMLVV 261
+ D+WS+GVVLYV++C SLPFD ++P + + +G F +S DC+ L++R+L
Sbjct: 189 KKGDVWSMGVVLYVMLCASLPFDDTDIPKMLWQQQKGVSFPTHLSISADCQDLLKRLLEP 248
Query: 262 DPARRITIAQIRQHRWM 278
D R +I ++ H W+
Sbjct: 249 DMILRPSIEEVSWHPWL 265
>gi|149589021 doublecortin-like kinase 3 [Homo sapiens]
Length = 648
Score = 184 bits (468), Expect = 2e-46
Identities = 103/262 (39%), Positives = 155/262 (59%), Gaps = 14/262 (5%)
Query: 27 YDIERTLGKGNFAVVKLARHRVTKTQVAIKIIDKTRLDSSNLEKIYREVQLMKLLNHPHI 86
Y+ R +G GNFAVVK RHR T+ A+KIIDK+RL + + E+ +++ L+HP+I
Sbjct: 356 YETGRVIGDGNFAVVKECRHRETRQAYAMKIIDKSRLKGKE-DMVDSEILIIQSLSHPNI 414
Query: 87 IKLYQVMETKDMLYIVTEFAKNGEMFDYLTSNGHLSENEARKKFWQILSAVEYCHDHHIV 146
+KL++V ET +Y++ E+ + G++FD + + E +A + A+ + HD IV
Sbjct: 415 VKLHEVYETDMEIYLILEYVQGGDLFDAIIESVKFPEPDAALMIMDLCKALVHMHDKSIV 474
Query: 147 HRDLKTENLLLDGNMD----IKLADFGFGNFYKSGEPLSTWCGSPPYAAPEVFEGKEYEG 202
HRDLK ENLL+ N D +KLADFG P+ T CG+P Y APE+ K Y G
Sbjct: 475 HRDLKPENLLVQRNEDKSTTLKLADFGLAKHVV--RPIFTVCGTPTYVAPEILSEKGY-G 531
Query: 203 PQLDIWSLGVVLYVLVCGSLPFDGP--NLPTLRQRVLEGRFRI--PFF--MSQDCESLIR 256
++D+W+ GV+LY+L+CG PF P + L + G F P++ +S + L+
Sbjct: 532 LEVDMWAAGVILYILLCGFPPFRSPERDQDELFNIIQLGHFEFLPPYWDNISDAAKDLVS 591
Query: 257 RMLVVDPARRITIAQIRQHRWM 278
R+LVVDP +R T Q+ QH W+
Sbjct: 592 RLLVVDPKKRYTAHQVLQHPWI 613
Database: hs.faa
Posted date: Aug 4, 2009 4:42 PM
Number of letters in database: 18,247,518
Number of sequences in database: 37,866
Lambda K H
0.318 0.135 0.407
Gapped
Lambda K H
0.267 0.0410 0.140
Matrix: BLOSUM62
Gap Penalties: Existence: 11, Extension: 1
Number of Hits to DB: 34,514,321
Number of Sequences: 37866
Number of extensions: 1937902
Number of successful extensions: 13001
Number of sequences better than 10.0: 30
Number of HSP's better than 10.0 without gapping: 756
Number of HSP's successfully gapped in prelim test: 475
Number of HSP's that attempted gapping in prelim test: 8786
Number of HSP's gapped (non-prelim): 2829
length of query: 783
length of database: 18,247,518
effective HSP length: 110
effective length of query: 673
effective length of database: 14,082,258
effective search space: 9477359634
effective search space used: 9477359634
T: 11
A: 40
X1: 16 ( 7.3 bits)
X2: 38 (14.6 bits)
X3: 64 (24.7 bits)
S1: 41 (21.7 bits)
S2: 66 (30.0 bits)
Search results were obtained with NCBI BLAST and RefSeq entries.
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Guide to the Human Genome
Copyright © 2010 by Stewart Scherer. All rights reserved.