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Search of human proteins with 23957680
BLASTP 2.2.11 [Jun-05-2005]
Reference: Altschul, Stephen F., Thomas L. Madden, Alejandro A. Schaffer,
Jinghui Zhang, Zheng Zhang, Webb Miller, and David J. Lipman (1997),
"Gapped BLAST and PSI-BLAST: a new generation of protein database search
programs", Nucleic Acids Res. 25:3389-3402.
Query= gi|23957680 ral guanine nucleotide dissociation stimulator-like
4 [Homo sapiens]
(473 letters)
Database: hs.faa
37,866 sequences; 18,247,518 total letters
Searching..................................................done
Score E
Sequences producing significant alignments: (bits) Value
gi|23957680 ral guanine nucleotide dissociation stimulator-like ... 967 0.0
gi|24307909 ral guanine nucleotide dissociation stimulator isofo... 329 3e-90
gi|108796058 ral guanine nucleotide dissociation stimulator isof... 329 3e-90
gi|93102367 ral guanine nucleotide dissociation stimulator-like ... 228 1e-59
gi|239582765 ral guanine nucleotide dissociation stimulator-like... 180 3e-45
gi|239582763 ral guanine nucleotide dissociation stimulator-like... 180 3e-45
gi|4758532 ral guanine nucleotide dissociation stimulator-like 2... 171 1e-42
gi|7662070 Ral GEF with PH domain and SH3 binding motif 1 [Homo ... 101 2e-21
gi|32441283 Ral GEF with PH domain and SH3 binding motif 2 [Homo... 94 2e-19
gi|224586880 Ras protein-specific guanine nucleotide-releasing f... 92 8e-19
gi|24797099 Ras protein-specific guanine nucleotide-releasing fa... 92 8e-19
gi|24797101 Ras protein-specific guanine nucleotide-releasing fa... 92 8e-19
gi|38373677 guanine nucleotide-releasing factor 2 isoform b [Hom... 92 1e-18
gi|38373675 guanine nucleotide-releasing factor 2 isoform a [Hom... 92 1e-18
gi|38505170 Ras protein-specific guanine nucleotide-releasing fa... 91 2e-18
gi|15529996 son of sevenless homolog 1 [Homo sapiens] 75 2e-13
gi|154689780 son of sevenless homolog 2 [Homo sapiens] 71 2e-12
gi|47551356 hypothetical protein LOC408029 [Homo sapiens] 63 5e-10
gi|22749129 RasGEF domain family, member 1B [Homo sapiens] 63 7e-10
gi|47524184 hypothetical protein LOC29798 [Homo sapiens] 62 9e-10
gi|169215684 PREDICTED: hypothetical protein [Homo sapiens] 62 1e-09
gi|40255197 RasGEF domain family, member 1C [Homo sapiens] 61 2e-09
gi|24797103 RAS guanyl releasing protein 2 [Homo sapiens] 61 3e-09
gi|149158729 RAS guanyl releasing protein 2 [Homo sapiens] 61 3e-09
gi|149158727 RAS guanyl releasing protein 2 [Homo sapiens] 61 3e-09
gi|89037235 PREDICTED: hypothetical protein [Homo sapiens] 60 6e-09
gi|239747182 PREDICTED: hypothetical protein XP_002343934 [Homo ... 58 2e-08
gi|89058402 PREDICTED: hypothetical protein [Homo sapiens] 58 2e-08
gi|117168263 RasGEF domain family, member 1A [Homo sapiens] 56 6e-08
gi|54633319 PDZ domain-containing guanine nucleotide exchange fa... 52 1e-06
>gi|23957680 ral guanine nucleotide dissociation stimulator-like 4
[Homo sapiens]
Length = 473
Score = 967 bits (2501), Expect = 0.0
Identities = 473/473 (100%), Positives = 473/473 (100%)
Query: 1 MRKLLTNLPAAAVLSAQVYSAVLQGLWEENVCGTPGRTRVCTALLYGQVCPFQDSTDGLR 60
MRKLLTNLPAAAVLSAQVYSAVLQGLWEENVCGTPGRTRVCTALLYGQVCPFQDSTDGLR
Sbjct: 1 MRKLLTNLPAAAVLSAQVYSAVLQGLWEENVCGTPGRTRVCTALLYGQVCPFQDSTDGLR 60
Query: 61 TITSILFNWPPENTSVYYQPPQRSSFRIKLAFRNLSWPGLGLEDHQEIVLGQLVLPEPNE 120
TITSILFNWPPENTSVYYQPPQRSSFRIKLAFRNLSWPGLGLEDHQEIVLGQLVLPEPNE
Sbjct: 61 TITSILFNWPPENTSVYYQPPQRSSFRIKLAFRNLSWPGLGLEDHQEIVLGQLVLPEPNE 120
Query: 121 AKPDDPAPRPGQHALTMPALEPAPPLLADLGPALEPESPAALGPPGYLHSAPGPAPAPGE 180
AKPDDPAPRPGQHALTMPALEPAPPLLADLGPALEPESPAALGPPGYLHSAPGPAPAPGE
Sbjct: 121 AKPDDPAPRPGQHALTMPALEPAPPLLADLGPALEPESPAALGPPGYLHSAPGPAPAPGE 180
Query: 181 GPPPGTVLEPQSAPESSCPCRGSVKNQPSEELPDMTTFPPRLLAEQLTLMDAELFKKVVL 240
GPPPGTVLEPQSAPESSCPCRGSVKNQPSEELPDMTTFPPRLLAEQLTLMDAELFKKVVL
Sbjct: 181 GPPPGTVLEPQSAPESSCPCRGSVKNQPSEELPDMTTFPPRLLAEQLTLMDAELFKKVVL 240
Query: 241 HECLGCIWGQGHLKGNEHMAPTVRATIAHFNRLTNCITTSCLGDHSMRARDRARVVEHWI 300
HECLGCIWGQGHLKGNEHMAPTVRATIAHFNRLTNCITTSCLGDHSMRARDRARVVEHWI
Sbjct: 241 HECLGCIWGQGHLKGNEHMAPTVRATIAHFNRLTNCITTSCLGDHSMRARDRARVVEHWI 300
Query: 301 KVARECLSLNNFSSVHVIVSALCSNPIGQLHKTWAGVSSKSMKELKELCKKDTAVKRDLL 360
KVARECLSLNNFSSVHVIVSALCSNPIGQLHKTWAGVSSKSMKELKELCKKDTAVKRDLL
Sbjct: 301 KVARECLSLNNFSSVHVIVSALCSNPIGQLHKTWAGVSSKSMKELKELCKKDTAVKRDLL 360
Query: 361 IKAGSFKVATQERNPQRVQMRLRRQKKGVVPFLGDFLTELQRLDSAIPDDLDGNTNKRSK 420
IKAGSFKVATQERNPQRVQMRLRRQKKGVVPFLGDFLTELQRLDSAIPDDLDGNTNKRSK
Sbjct: 361 IKAGSFKVATQERNPQRVQMRLRRQKKGVVPFLGDFLTELQRLDSAIPDDLDGNTNKRSK 420
Query: 421 EVRVLQEMQLLQVAAMNYRLRPLEKFVTYFTRMEQLSDKESYKLSCQLEPENP 473
EVRVLQEMQLLQVAAMNYRLRPLEKFVTYFTRMEQLSDKESYKLSCQLEPENP
Sbjct: 421 EVRVLQEMQLLQVAAMNYRLRPLEKFVTYFTRMEQLSDKESYKLSCQLEPENP 473
>gi|24307909 ral guanine nucleotide dissociation stimulator isoform
1 [Homo sapiens]
Length = 914
Score = 329 bits (844), Expect = 3e-90
Identities = 201/472 (42%), Positives = 266/472 (56%), Gaps = 47/472 (9%)
Query: 46 YGQVCPFQDSTDGLR-----TITSILFNWPPENTSVYYQPPQRSSFRIKLAFRNLSWPGL 100
YG + P+ D G + I+SIL W + + + QPP + +A+ L+ PG
Sbjct: 176 YGCILPYSDEDGGPQDQLKNAISSILGTWLDQYSEDFCQPPDFPCLKQLVAYVQLNMPGS 235
Query: 101 GLEDHQEIVLGQLVLPEPNEAKPDD----------------------PAPRPGQHALTMP 138
LE ++L QL EP EA+P+ P+P P P
Sbjct: 236 DLERRAHLLLAQLEHSEPIEAEPEALSPVPALKPTPELELALTPARAPSPVPAPAPEPEP 295
Query: 139 ALEPAPPLLADLGPALEPESPAALGPPGYLHSAPGPA----PAPGEGPPPGTVLEPQSAP 194
A PAP ++ PA PE A P L SAP PA PAP + P P LE + AP
Sbjct: 296 APTPAPGSELEVAPAPAPELQQAPEPAVGLESAPAPALELEPAPEQDPAPSQTLELEPAP 355
Query: 195 ------ESSCPCRGSVKNQPSEELPDMTTFPPRLLAEQLTLMDAELFKKVVLHECLGCIW 248
+ S P +N SEE P + FPP L+AEQ TLMDAELFKKVV + CLG IW
Sbjct: 356 APVPSLQPSWPSPVVAENGLSEEKPHLLVFPPDLVAEQFTLMDAELFKKVVPYHCLGSIW 415
Query: 249 GQGHLKGNEHMAPTVRATIAHFNRLTNCITTSCLGDHSMRARDRARVVEHWIKVARECLS 308
Q KG EH+APT+RAT+ FN + NC+ T+CLG+ S +A DRARVVEHWI+VAREC
Sbjct: 416 SQRDKKGKEHLAPTIRATVTQFNSVANCVITTCLGNRSTKAPDRARVVEHWIEVARECRI 475
Query: 309 LNNFSSVHVIVSALCSNPIGQLHKTWAGVSSKSMKELKELC-----KKDTAVKRDLLIKA 363
L NFSS++ I+SAL SN I +L KTW VS S + ++L + + ++ R+LLIK
Sbjct: 476 LKNFSSLYAILSALQSNSIHRLKKTWEDVSRDSFRIFQKLSEIFSDENNYSLSRELLIKE 535
Query: 364 GSFKVATQERNPQRVQMRLRRQK--KGVVPFLGDFLTELQRLDSAIPDDLDG---NTNKR 418
G+ K AT E NP+R Q R + +G VP+LG FLT+L LD+A+ D L G N KR
Sbjct: 536 GTSKFATLEMNPKRAQKRPKETGIIQGTVPYLGTFLTDLVMLDTAMKDYLYGRLINFEKR 595
Query: 419 SKEVRVLQEMQLLQVAAMNYRLRPLEKFVTYFTRMEQLSDKESYKLSCQLEP 470
KE V+ +++LLQ A NY + P E+F +F +E+LS+ ESY LSC+LEP
Sbjct: 596 RKEFEVIAQIKLLQSACNNYSIAPDEQFGAWFRAVERLSETESYNLSCELEP 647
>gi|108796058 ral guanine nucleotide dissociation stimulator isoform
2 [Homo sapiens]
Length = 859
Score = 329 bits (844), Expect = 3e-90
Identities = 201/472 (42%), Positives = 266/472 (56%), Gaps = 47/472 (9%)
Query: 46 YGQVCPFQDSTDGLR-----TITSILFNWPPENTSVYYQPPQRSSFRIKLAFRNLSWPGL 100
YG + P+ D G + I+SIL W + + + QPP + +A+ L+ PG
Sbjct: 121 YGCILPYSDEDGGPQDQLKNAISSILGTWLDQYSEDFCQPPDFPCLKQLVAYVQLNMPGS 180
Query: 101 GLEDHQEIVLGQLVLPEPNEAKPDD----------------------PAPRPGQHALTMP 138
LE ++L QL EP EA+P+ P+P P P
Sbjct: 181 DLERRAHLLLAQLEHSEPIEAEPEALSPVPALKPTPELELALTPARAPSPVPAPAPEPEP 240
Query: 139 ALEPAPPLLADLGPALEPESPAALGPPGYLHSAPGPA----PAPGEGPPPGTVLEPQSAP 194
A PAP ++ PA PE A P L SAP PA PAP + P P LE + AP
Sbjct: 241 APTPAPGSELEVAPAPAPELQQAPEPAVGLESAPAPALELEPAPEQDPAPSQTLELEPAP 300
Query: 195 ------ESSCPCRGSVKNQPSEELPDMTTFPPRLLAEQLTLMDAELFKKVVLHECLGCIW 248
+ S P +N SEE P + FPP L+AEQ TLMDAELFKKVV + CLG IW
Sbjct: 301 APVPSLQPSWPSPVVAENGLSEEKPHLLVFPPDLVAEQFTLMDAELFKKVVPYHCLGSIW 360
Query: 249 GQGHLKGNEHMAPTVRATIAHFNRLTNCITTSCLGDHSMRARDRARVVEHWIKVARECLS 308
Q KG EH+APT+RAT+ FN + NC+ T+CLG+ S +A DRARVVEHWI+VAREC
Sbjct: 361 SQRDKKGKEHLAPTIRATVTQFNSVANCVITTCLGNRSTKAPDRARVVEHWIEVARECRI 420
Query: 309 LNNFSSVHVIVSALCSNPIGQLHKTWAGVSSKSMKELKELC-----KKDTAVKRDLLIKA 363
L NFSS++ I+SAL SN I +L KTW VS S + ++L + + ++ R+LLIK
Sbjct: 421 LKNFSSLYAILSALQSNSIHRLKKTWEDVSRDSFRIFQKLSEIFSDENNYSLSRELLIKE 480
Query: 364 GSFKVATQERNPQRVQMRLRRQK--KGVVPFLGDFLTELQRLDSAIPDDLDG---NTNKR 418
G+ K AT E NP+R Q R + +G VP+LG FLT+L LD+A+ D L G N KR
Sbjct: 481 GTSKFATLEMNPKRAQKRPKETGIIQGTVPYLGTFLTDLVMLDTAMKDYLYGRLINFEKR 540
Query: 419 SKEVRVLQEMQLLQVAAMNYRLRPLEKFVTYFTRMEQLSDKESYKLSCQLEP 470
KE V+ +++LLQ A NY + P E+F +F +E+LS+ ESY LSC+LEP
Sbjct: 541 RKEFEVIAQIKLLQSACNNYSIAPDEQFGAWFRAVERLSETESYNLSCELEP 592
>gi|93102367 ral guanine nucleotide dissociation stimulator-like 1
[Homo sapiens]
Length = 803
Score = 228 bits (580), Expect = 1e-59
Identities = 123/276 (44%), Positives = 175/276 (63%), Gaps = 17/276 (6%)
Query: 211 ELPDMTTFPPRLLAEQLTLMDAELFKKVVLHECLGCIWGQGHLKGNEHMAPTVRATIAHF 270
E + T F L+AEQLT MDA+LFKKVV H CLGCIW + K N+H+APT+RATI+ F
Sbjct: 259 ESAEFTCFSEDLVAEQLTYMDAQLFKKVVPHHCLGCIWSRRDKKENKHLAPTIRATISQF 318
Query: 271 NRLTNCITTSCLGDHSMRARDRARVVEHWIKVARECLSLNNFSSVHVIVSALCSNPIGQL 330
N LT C+ ++ LG ++ + RA+++E WI +A EC L NFSS+ IVSAL SN I +L
Sbjct: 319 NTLTKCVVSTILGGKELKTQQRAKIIEKWINIAHECRLLKNFSSLRAIVSALQSNSIYRL 378
Query: 331 HKTWAGVSSKSMKELKELC-----KKDTAVKRDLLIKAGSFKVA----TQERNPQRVQMR 381
KTWA V M +EL + R+LL+K G+ K A + + N +R Q R
Sbjct: 379 KKTWAAVPRDRMLMFEELSDIFSDHNNHLTSRELLMKEGTSKFANLDSSVKENQKRTQRR 438
Query: 382 LRRQK-----KGVVPFLGDFLTELQRLDSAIPDDLDG---NTNKRSKEVRVLQEMQLLQV 433
L+ QK +G VP+LG FLT+L LD+A+ D ++G N KR +E V+ +++LLQ
Sbjct: 439 LQLQKDMGVMQGTVPYLGTFLTDLTMLDTALQDYIEGGLINFEKRRREFEVIAQIKLLQS 498
Query: 434 AAMNYRLRPLEKFVTYFTRMEQLSDKESYKLSCQLE 469
A +Y + P +KF+ +F R + L+++ESY LSC++E
Sbjct: 499 ACNSYCMTPDQKFIQWFQRQQLLTEEESYALSCEIE 534
>gi|239582765 ral guanine nucleotide dissociation stimulator-like 3
isoform 1 [Homo sapiens]
Length = 716
Score = 180 bits (456), Expect = 3e-45
Identities = 121/346 (34%), Positives = 175/346 (50%), Gaps = 22/346 (6%)
Query: 144 PPLLADLGPA------LEPESPAALGPPGYLHSAPGPAPAPGEGPPPGTVLEPQSAPESS 197
PP +DLG P S A L A E PP P ++S
Sbjct: 162 PPAHSDLGSVRTFLGWAAPGSAEAQKAEKLLEDFLEEAEREQEEEPPQVWTGPPRVAQTS 221
Query: 198 CPCRGSVKNQPSEEL----PDMTTFPPRLLAEQLTLMDAELFKKVVLHECLGCIWGQGHL 253
P + E L P + F +AEQLTL+D ELF KV L+ECLG +W Q
Sbjct: 222 DPDSSEACAEEEEGLMPQGPQLLDFSVDEVAEQLTLIDLELFSKVRLYECLGSVWSQRDR 281
Query: 254 KGNEHMAPTVRATIAHFNRLTNCITTSCLGDHSMRARDRARVVEHWIKVARECLSLNNFS 313
G +PTVRAT+A FN +T C+ S LG + A RA+ +E WI++A+ C L NFS
Sbjct: 282 PGAAGASPTVRATVAQFNTVTGCVLGSVLGAPGLAAPQRAQRLEKWIRIAQRCRELRNFS 341
Query: 314 SVHVIVSALCSNPIGQLHKTWAGVSSKSMKELKELC-----KKDTAVKRDLLIKAGSFKV 368
S+ I+SAL SNPI +L ++W VS + + ++L + + R++L + + +
Sbjct: 342 SLRAILSALQSNPIYRLKRSWGAVSREPLSTFRKLSQIFSDENNHLSSREILFQEEATEG 401
Query: 369 ATQERN-PQRVQMRLRRQKKGVVPFLGDFLTELQRLDSAIPDDLDG---NTNKRSKEVRV 424
+ +E N P + + G VP+LG FLT+L LD+A+PD L+G N KR KE +
Sbjct: 402 SQEEDNTPGSLP---SKPPPGPVPYLGTFLTDLVMLDTALPDMLEGDLINFEKRRKEWEI 458
Query: 425 LQEMQLLQVAAMNYRLRPLEKFVTYFTRMEQLSDKESYKLSCQLEP 470
L +Q LQ +Y L P + QL++++SY+LS +EP
Sbjct: 459 LARIQQLQRRCQSYTLSPHPPILAALHAQNQLTEEQSYRLSRVIEP 504
>gi|239582763 ral guanine nucleotide dissociation stimulator-like 3
isoform 2 [Homo sapiens]
Length = 710
Score = 180 bits (456), Expect = 3e-45
Identities = 121/346 (34%), Positives = 175/346 (50%), Gaps = 22/346 (6%)
Query: 144 PPLLADLGPA------LEPESPAALGPPGYLHSAPGPAPAPGEGPPPGTVLEPQSAPESS 197
PP +DLG P S A L A E PP P ++S
Sbjct: 162 PPAHSDLGSVRTFLGWAAPGSAEAQKAEKLLEDFLEEAEREQEEEPPQVWTGPPRVAQTS 221
Query: 198 CPCRGSVKNQPSEEL----PDMTTFPPRLLAEQLTLMDAELFKKVVLHECLGCIWGQGHL 253
P + E L P + F +AEQLTL+D ELF KV L+ECLG +W Q
Sbjct: 222 DPDSSEACAEEEEGLMPQGPQLLDFSVDEVAEQLTLIDLELFSKVRLYECLGSVWSQRDR 281
Query: 254 KGNEHMAPTVRATIAHFNRLTNCITTSCLGDHSMRARDRARVVEHWIKVARECLSLNNFS 313
G +PTVRAT+A FN +T C+ S LG + A RA+ +E WI++A+ C L NFS
Sbjct: 282 PGAAGASPTVRATVAQFNTVTGCVLGSVLGAPGLAAPQRAQRLEKWIRIAQRCRELRNFS 341
Query: 314 SVHVIVSALCSNPIGQLHKTWAGVSSKSMKELKELC-----KKDTAVKRDLLIKAGSFKV 368
S+ I+SAL SNPI +L ++W VS + + ++L + + R++L + + +
Sbjct: 342 SLRAILSALQSNPIYRLKRSWGAVSREPLSTFRKLSQIFSDENNHLSSREILFQEEATEG 401
Query: 369 ATQERN-PQRVQMRLRRQKKGVVPFLGDFLTELQRLDSAIPDDLDG---NTNKRSKEVRV 424
+ +E N P + + G VP+LG FLT+L LD+A+PD L+G N KR KE +
Sbjct: 402 SQEEDNTPGSLP---SKPPPGPVPYLGTFLTDLVMLDTALPDMLEGDLINFEKRRKEWEI 458
Query: 425 LQEMQLLQVAAMNYRLRPLEKFVTYFTRMEQLSDKESYKLSCQLEP 470
L +Q LQ +Y L P + QL++++SY+LS +EP
Sbjct: 459 LARIQQLQRRCQSYTLSPHPPILAALHAQNQLTEEQSYRLSRVIEP 504
>gi|4758532 ral guanine nucleotide dissociation stimulator-like 2
[Homo sapiens]
Length = 777
Score = 171 bits (434), Expect = 1e-42
Identities = 105/303 (34%), Positives = 165/303 (54%), Gaps = 25/303 (8%)
Query: 188 LEPQSAPESSCPCRGSVKNQPSEELPDMTTFPPRLLAEQLTLMDAELFKKVVLHECLGCI 247
++PQ AP+ P ++ P + D+ F LAEQLTL+DAELF ++ +CLG +
Sbjct: 215 VDPQ-APDLPKPL--ALPGDPPADPTDVLVFLADHLAEQLTLLDAELFLNLIPSQCLGGL 271
Query: 248 WGQGHLKGNEHMAPTVRATIAHFNRLTNCITTSCLGDHS------------MRARDRARV 295
WG G+ H+ P+VRAT+ FN++ + +S LG S +R RAR+
Sbjct: 272 WGHRDRPGHSHLCPSVRATVTQFNKVAGAVVSSVLGATSTGEGPGEVTIRPLRPPQRARL 331
Query: 296 VEHWIKVARECLSLNNFSSVHVIVSALCSNPIGQLHKTWAGVSSKSMKELKELC-----K 350
+E WI+VA EC L NFSSV+ +VSAL S+PI +L W + S++ LC +
Sbjct: 332 LEKWIRVAEECRLLRNFSSVYAVVSALQSSPIHRLRAAWGEATRDSLRVFSSLCQIFSEE 391
Query: 351 KDTAVKRDLLIKAGSFKVATQERNPQRVQMRLRRQKKGVVPFLGDFLTELQRLDSAIPDD 410
+ + R+LL++ K+ + + R + GVVP+LG FL +L LD+A D+
Sbjct: 392 DNYSQSRELLVQ--EVKLQSPLEPHSKKAPRSGSRGGGVVPYLGTFLKDLVMLDAASKDE 449
Query: 411 LDG---NTNKRSKEVRVLQEMQLLQVAAMNYRLRPLEKFVTYFTRMEQLSDKESYKLSCQ 467
L+ N +KR KE VL E++ LQ Y L+P + + L++ +S+++SC+
Sbjct: 450 LENGYINFDKRRKEFAVLSELRRLQNECRGYNLQPDHDIQRWLQGLRPLTEAQSHRVSCE 509
Query: 468 LEP 470
+EP
Sbjct: 510 VEP 512
>gi|7662070 Ral GEF with PH domain and SH3 binding motif 1 [Homo
sapiens]
Length = 557
Score = 101 bits (251), Expect = 2e-21
Identities = 79/266 (29%), Positives = 131/266 (49%), Gaps = 31/266 (11%)
Query: 214 DMTTFPPRLLAEQLTLMDAELFKKVVLHECLGCIWGQGHLKGNEHMAPTVRATIAHFNRL 273
D+ P A Q+TLMD +FK + E C W + K +AP V A FN++
Sbjct: 45 DVLKVTPEEFASQITLMDIPVFKAIQPEELASCGWSK---KEKHSLAPNVVAFTRRFNQV 101
Query: 274 TNCITTSCLGDHSMRARDRARVVEHWIKVARECLSLNNFSSVHVIVSALCSNPIGQLHKT 333
+ + L +++ R A ++ H++K+A++ L LNN S+ +VSAL S PI +L KT
Sbjct: 102 SFWVVREILTAQTLKIR--AEILSHFVKIAKKLLELNNLHSLMSVVSALQSAPIFRLTKT 159
Query: 334 WAGVSSKSMKELKELCKKDTAVKRDLLIKAGSFKVATQERNPQRVQMRLRRQKK-GVVPF 392
WA ++ K K T K D L+ ++E N +R + +R K +P+
Sbjct: 160 WALLNRKD---------KTTFEKLDYLM--------SKEDNYKRTREYIRSLKMVPSIPY 202
Query: 393 LGDFLTELQRLDSAIP--DDLDGNTNKRSKEVRVLQEMQLLQVAAMNYRLRPLE------ 444
LG +L +L +DSA P + N + ++ +L+ + LQV+ L L
Sbjct: 203 LGIYLLDLIYIDSAYPASGSIMENEQRSNQMNNILRIIADLQVSCSYDHLTTLPHVQKYL 262
Query: 445 KFVTYFTRMEQLSDKESYKLSCQLEP 470
K V Y +++ + ++YKLS ++EP
Sbjct: 263 KSVRYIEELQKFVEDDNYKLSLRIEP 288
>gi|32441283 Ral GEF with PH domain and SH3 binding motif 2 [Homo
sapiens]
Length = 583
Score = 94.4 bits (233), Expect = 2e-19
Identities = 79/295 (26%), Positives = 137/295 (46%), Gaps = 34/295 (11%)
Query: 186 TVLEPQSAPESSCPCRGSVKNQPSEELPDMTTFPPRLLAEQLTLMDAELFKKVVLHECLG 245
T E S+ ES +K + D+ P A Q+TLMD +FK + E
Sbjct: 16 TASEKSSSSESLSDKGSELKKSFDAVVFDVLKVTPEEYAGQITLMDVPVFKAIQPDELSS 75
Query: 246 CIWGQGHLKGNEHMAPTVRATIAHFNRLTNCITTSCLGDHSMRARDRARVVEHWIKVARE 305
C W + K AP A FN ++ + L H+ + RA V+ H+IK A++
Sbjct: 76 CGWNK---KEKYSSAPNAVAFTRRFNHVSFWVVREIL--HAQTLKIRAEVLSHYIKTAKK 130
Query: 306 CLSLNNFSSVHVIVSALCSNPIGQLHKTWAGVSSKSMKELKELCKKDTAVKRDLLIKAGS 365
LNN ++ +VS L S PI +L KTWA +S K ++L
Sbjct: 131 LYELNNLHALMAVVSGLQSAPIFRLTKTWALLSRKDKTTFEKL----------------- 173
Query: 366 FKVATQERNPQRVQMRLRRQK-KGVVPFLGDFLTELQRLDSAIPD-----DLDGNTNKRS 419
V ++E N +R++ + K +P+LG +L++L +DSA P + + +N +
Sbjct: 174 EYVMSKEDNYKRLRDYISSLKMTPCIPYLGIYLSDLTYIDSAYPSTGSILENEQRSNLMN 233
Query: 420 KEVRVLQEMQLLQVAAMNYRLRP-LEKF---VTYFTRMEQLSDKESYKLSCQLEP 470
+R++ ++Q Q + + P ++K+ V Y +++ + ++YKLS ++EP
Sbjct: 234 NILRIISDLQ--QSCEYDIPMLPHVQKYLNSVQYIEELQKFVEDDNYKLSLKIEP 286
>gi|224586880 Ras protein-specific guanine nucleotide-releasing factor
1 isoform 3 [Homo sapiens]
Length = 1257
Score = 92.4 bits (228), Expect = 8e-19
Identities = 74/255 (29%), Positives = 126/255 (49%), Gaps = 28/255 (10%)
Query: 223 LAEQLTLMDAELFKKVVLHECLGCIWGQGHLKGNEHMAPTVRATIAHFNRLTNCITTSCL 282
+AEQLTL+D +FKK+ E G W + L+ NE P + T HFN ++N I + +
Sbjct: 1026 IAEQLTLLDHLVFKKIPYEEFFGQGWMK--LEKNER-TPYIMKTTKHFNDISNLIASEII 1082
Query: 283 GDHSMRARDRARVVEHWIKVARECLSLNNFSSVHVIVSALCSNPIGQLHKTWAGVSSKSM 342
+ + AR A +E W+ VA C L+N+++V I S++ + I +L KTW VS ++
Sbjct: 1083 RNEDINARVSA--IEKWVAVADICRCLHNYNAVLEITSSMNRSAIFRLKKTWLKVSKQTK 1140
Query: 343 KELKELCKKDTAVKRDLLIKAGSFKVATQERNPQRVQMRLRRQKKGVVPFLGDFLTELQR 402
+ +L K L+ G FK ++ L+ VP+LG +LT+L
Sbjct: 1141 ALIDKLQK--------LVSSEGRFK---------NLREALKNCDPPCVPYLGMYLTDLAF 1183
Query: 403 LDSAIPDDLDG---NTNKRSKEVRVLQEMQLLQVAAMNYRLRPLEKFVTYFTRMEQLSDK 459
++ P+ + N +K +++E++ Q A Y++ K Y + D+
Sbjct: 1184 IEEGTPNYTEDGLVNFSKMRMISHIIREIRQFQQTA--YKIEHQAKVTQYLLDQSFVMDE 1241
Query: 460 ES-YKLSCQLEPENP 473
ES Y+ S ++EP+ P
Sbjct: 1242 ESLYESSLRIEPKLP 1256
>gi|24797099 Ras protein-specific guanine nucleotide-releasing factor
1 isoform 1 [Homo sapiens]
Length = 1273
Score = 92.4 bits (228), Expect = 8e-19
Identities = 74/255 (29%), Positives = 126/255 (49%), Gaps = 28/255 (10%)
Query: 223 LAEQLTLMDAELFKKVVLHECLGCIWGQGHLKGNEHMAPTVRATIAHFNRLTNCITTSCL 282
+AEQLTL+D +FKK+ E G W + L+ NE P + T HFN ++N I + +
Sbjct: 1042 IAEQLTLLDHLVFKKIPYEEFFGQGWMK--LEKNER-TPYIMKTTKHFNDISNLIASEII 1098
Query: 283 GDHSMRARDRARVVEHWIKVARECLSLNNFSSVHVIVSALCSNPIGQLHKTWAGVSSKSM 342
+ + AR A +E W+ VA C L+N+++V I S++ + I +L KTW VS ++
Sbjct: 1099 RNEDINARVSA--IEKWVAVADICRCLHNYNAVLEITSSMNRSAIFRLKKTWLKVSKQTK 1156
Query: 343 KELKELCKKDTAVKRDLLIKAGSFKVATQERNPQRVQMRLRRQKKGVVPFLGDFLTELQR 402
+ +L K L+ G FK ++ L+ VP+LG +LT+L
Sbjct: 1157 ALIDKLQK--------LVSSEGRFK---------NLREALKNCDPPCVPYLGMYLTDLAF 1199
Query: 403 LDSAIPDDLDG---NTNKRSKEVRVLQEMQLLQVAAMNYRLRPLEKFVTYFTRMEQLSDK 459
++ P+ + N +K +++E++ Q A Y++ K Y + D+
Sbjct: 1200 IEEGTPNYTEDGLVNFSKMRMISHIIREIRQFQQTA--YKIEHQAKVTQYLLDQSFVMDE 1257
Query: 460 ES-YKLSCQLEPENP 473
ES Y+ S ++EP+ P
Sbjct: 1258 ESLYESSLRIEPKLP 1272
>gi|24797101 Ras protein-specific guanine nucleotide-releasing
factor 1 isoform 2 [Homo sapiens]
Length = 489
Score = 92.4 bits (228), Expect = 8e-19
Identities = 74/255 (29%), Positives = 126/255 (49%), Gaps = 28/255 (10%)
Query: 223 LAEQLTLMDAELFKKVVLHECLGCIWGQGHLKGNEHMAPTVRATIAHFNRLTNCITTSCL 282
+AEQLTL+D +FKK+ E G W + L+ NE P + T HFN ++N I + +
Sbjct: 258 IAEQLTLLDHLVFKKIPYEEFFGQGWMK--LEKNER-TPYIMKTTKHFNDISNLIASEII 314
Query: 283 GDHSMRARDRARVVEHWIKVARECLSLNNFSSVHVIVSALCSNPIGQLHKTWAGVSSKSM 342
+ + AR A +E W+ VA C L+N+++V I S++ + I +L KTW VS ++
Sbjct: 315 RNEDINARVSA--IEKWVAVADICRCLHNYNAVLEITSSMNRSAIFRLKKTWLKVSKQTK 372
Query: 343 KELKELCKKDTAVKRDLLIKAGSFKVATQERNPQRVQMRLRRQKKGVVPFLGDFLTELQR 402
+ +L K L+ G FK ++ L+ VP+LG +LT+L
Sbjct: 373 ALIDKLQK--------LVSSEGRFK---------NLREALKNCDPPCVPYLGMYLTDLAF 415
Query: 403 LDSAIPDDLDG---NTNKRSKEVRVLQEMQLLQVAAMNYRLRPLEKFVTYFTRMEQLSDK 459
++ P+ + N +K +++E++ Q A Y++ K Y + D+
Sbjct: 416 IEEGTPNYTEDGLVNFSKMRMISHIIREIRQFQQTA--YKIEHQAKVTQYLLDQSFVMDE 473
Query: 460 ES-YKLSCQLEPENP 473
ES Y+ S ++EP+ P
Sbjct: 474 ESLYESSLRIEPKLP 488
>gi|38373677 guanine nucleotide-releasing factor 2 isoform b [Homo
sapiens]
Length = 1095
Score = 91.7 bits (226), Expect = 1e-18
Identities = 71/253 (28%), Positives = 127/253 (50%), Gaps = 34/253 (13%)
Query: 223 LAEQLTLMDAELFKKVVLHECLGCIWGQGHLKGNEHMAPTVRATIAHFNRLTNCITTSCL 282
+AEQLTL+DAELF K+ + E L +W + + NE +P + HFN ++ + + +
Sbjct: 862 IAEQLTLLDAELFYKIEIPEVL--LWAK---EQNEEKSPNLTQFTEHFNNMSYWVRSIIM 916
Query: 283 GDHSMRARDRARVVEHWIKVARECLSLNNFSSVHVIVSALCSNPIGQLHKTWAGVSSKSM 342
+A+DR R++ +IK+ + LNNF+S I+SAL S PI +L W +S+ +
Sbjct: 917 LQE--KAQDRERLLLKFIKIMKHLRKLNNFNSYLAILSALDSAPIRRLE--WQKQTSEGL 972
Query: 343 KELKELCKKDTAVKRDLLIKAGSFKVATQERNPQRVQMRLRRQKKGVVPFLGDFLTELQR 402
E L ++ + +++ A E P +P+LG L +L
Sbjct: 973 AEYCTLIDSSSSFR--------AYRAALSEVEPP------------CIPYLGLILQDLTF 1012
Query: 403 LDSAIPDDLDGNTN--KRSKEVRVLQEMQLLQVAAMNYRLRPLEKFVTYFTRM-EQLSDK 459
+ PD +DG N KR ++ +L M+ Q A +Y +R + + +F + L+++
Sbjct: 1013 VHLGNPDYIDGKVNFSKRWQQFNILDSMRCFQQA--HYDMRRNDDIINFFNDFSDHLAEE 1070
Query: 460 ESYKLSCQLEPEN 472
++LS +++P N
Sbjct: 1071 ALWELSLKIKPRN 1083
>gi|38373675 guanine nucleotide-releasing factor 2 isoform a [Homo
sapiens]
Length = 1077
Score = 91.7 bits (226), Expect = 1e-18
Identities = 71/253 (28%), Positives = 127/253 (50%), Gaps = 34/253 (13%)
Query: 223 LAEQLTLMDAELFKKVVLHECLGCIWGQGHLKGNEHMAPTVRATIAHFNRLTNCITTSCL 282
+AEQLTL+DAELF K+ + E L +W + + NE +P + HFN ++ + + +
Sbjct: 844 IAEQLTLLDAELFYKIEIPEVL--LWAK---EQNEEKSPNLTQFTEHFNNMSYWVRSIIM 898
Query: 283 GDHSMRARDRARVVEHWIKVARECLSLNNFSSVHVIVSALCSNPIGQLHKTWAGVSSKSM 342
+A+DR R++ +IK+ + LNNF+S I+SAL S PI +L W +S+ +
Sbjct: 899 LQE--KAQDRERLLLKFIKIMKHLRKLNNFNSYLAILSALDSAPIRRLE--WQKQTSEGL 954
Query: 343 KELKELCKKDTAVKRDLLIKAGSFKVATQERNPQRVQMRLRRQKKGVVPFLGDFLTELQR 402
E L ++ + +++ A E P +P+LG L +L
Sbjct: 955 AEYCTLIDSSSSFR--------AYRAALSEVEPP------------CIPYLGLILQDLTF 994
Query: 403 LDSAIPDDLDGNTN--KRSKEVRVLQEMQLLQVAAMNYRLRPLEKFVTYFTRM-EQLSDK 459
+ PD +DG N KR ++ +L M+ Q A +Y +R + + +F + L+++
Sbjct: 995 VHLGNPDYIDGKVNFSKRWQQFNILDSMRCFQQA--HYDMRRNDDIINFFNDFSDHLAEE 1052
Query: 460 ESYKLSCQLEPEN 472
++LS +++P N
Sbjct: 1053 ALWELSLKIKPRN 1065
>gi|38505170 Ras protein-specific guanine nucleotide-releasing factor
2 [Homo sapiens]
Length = 1237
Score = 91.3 bits (225), Expect = 2e-18
Identities = 74/254 (29%), Positives = 124/254 (48%), Gaps = 26/254 (10%)
Query: 223 LAEQLTLMDAELFKKVVLHECLGCIWGQGHLKGNEHMAPTVRATIAHFNRLTNCITTSCL 282
LAEQ+TL+D +F+ + E LG W + L NE P + T HFN ++N + + +
Sbjct: 1006 LAEQITLLDHVIFRSIPYEEFLGQGWMK--LDKNER-TPYIMKTSQHFNDMSNLVASQIM 1062
Query: 283 GDHSMRARDRARVVEHWIKVARECLSLNNFSSVHVIVSALCSNPIGQLHKTWAGVSSKSM 342
+ +R A +E W+ VA C L+N++ V I SAL + I +L KTWA V SK
Sbjct: 1063 NYADVSSR--ANAIEKWVAVADICRCLHNYNGVLEITSALNRSAIYRLKKTWAKV-SKQT 1119
Query: 343 KELKELCKKDTAVKRDLLIKAGSFKVATQERNPQRVQMRLRRQKKGVVPFLGDFLTELQR 402
K L + +K + G FK ++ L+ VP+LG +LT+L
Sbjct: 1120 KALMDKLQKTVS-------SEGRFK---------NLRETLKNCNPPAVPYLGMYLTDLAF 1163
Query: 403 LDSAIPDDLDGNTNKRSKEVRVLQEM--QLLQVAAMNYRLRPLEKFVTYFTRMEQLSDKE 460
++ P+ + SK +R++ + ++ Q +YR+ K Y + + D++
Sbjct: 1164 IEEGTPNFTEEGLVNFSK-MRMISHIIREIRQFQQTSYRIDHQPKVAQYLLDKDLIIDED 1222
Query: 461 S-YKLSCQLEPENP 473
+ Y+LS ++EP P
Sbjct: 1223 TLYELSLKIEPRLP 1236
>gi|15529996 son of sevenless homolog 1 [Homo sapiens]
Length = 1333
Score = 74.7 bits (182), Expect = 2e-13
Identities = 67/271 (24%), Positives = 119/271 (43%), Gaps = 35/271 (12%)
Query: 214 DMTTFPPRLLAEQLTLMDAELFKKVVLHECLGCIWGQGHLKGNEHMAPTVRATIAHFNRL 273
D+ T P +A QLTL++++L++ V E +G +W + + E +P + I H L
Sbjct: 775 DLLTLHPIEIARQLTLLESDLYRAVQPSELVGSVWTK---EDKEINSPNLLKMIRHTTNL 831
Query: 274 TNCITTSCLGDHSMRARDRARVVEHWIKVARECLSLNNFSSVHVIVSALCSNPIGQLHKT 333
T + ++ +R VV I++ + LNNF+ V +VSA+ S+P+ +L T
Sbjct: 832 TLWFEKCIVETENLE--ERVAVVSRIIEILQVFQELNNFNGVLEVVSAMNSSPVYRLDHT 889
Query: 334 WAGVSSKSMKELKELCKKDTAVKRDLLIKAGSFKVATQERNPQRVQMRLRRQKKGVVPFL 393
+ + S+ K L+E + E + ++ +LR VPF
Sbjct: 890 FEQIPSRQKKILEEAHE-------------------LSEDHYKKYLAKLRSINPPCVPFF 930
Query: 394 GDFLTELQRLDSAIPDDLDG------NTNKRSKEVRVLQEMQLLQVAAMNYRLR-PLEKF 446
G +LT + + + P+ L N +KR K + E+Q Q R+ +++F
Sbjct: 931 GIYLTNILKTEEGNPEVLKRHGKELINFSKRRKVAEITGEIQQYQNQPYCLRVESDIKRF 990
Query: 447 VTYFTRMEQLSDKE----SYKLSCQLEPENP 473
M +KE + S ++EP NP
Sbjct: 991 FENLNPMGNSMEKEFTDYLFNKSLEIEPRNP 1021
>gi|154689780 son of sevenless homolog 2 [Homo sapiens]
Length = 1332
Score = 70.9 bits (172), Expect = 2e-12
Identities = 77/308 (25%), Positives = 122/308 (39%), Gaps = 57/308 (18%)
Query: 180 EGPPPGTVLEPQSAPESSCPCRGSVKNQPSEELPDMTTFPPRLLAEQLTLMDAELFKKVV 239
E PPP P + E D+ T P +A QLTL++++L++KV
Sbjct: 753 ESPPP--------------PIEWHISKPGQFETFDLMTLHPIEIARQLTLLESDLYRKVQ 798
Query: 240 LHECLGCIWGQGHLKGNEHMAPTVRATIAHFNRLT----NCITTSCLGDHSMRARDRARV 295
E +G +W + + E +P + I H LT CI + +R V
Sbjct: 799 PSELVGSVWTK---EDKEINSPNLLKMIRHTTNLTLWFEKCIV------EAENFEERVAV 849
Query: 296 VEHWIKVARECLSLNNFSSVHVIVSALCSNPIGQLHKTWAGVSSKSMKELKELCKKDTAV 355
+ I++ + LNNF+ V IVSA+ S + +L T+ + + K L E +
Sbjct: 850 LSRIIEILQVFQDLNNFNGVLEIVSAVNSVSVYRLDHTFEALQERKRKILDEAVELSQDH 909
Query: 356 KRDLLIKAGSFKVATQERNPQRVQMRLRRQKKGVVPFLGDFLTELQRLDSAIPDDLDG-- 413
+ L+K S NP VPF G +LT + + + D L
Sbjct: 910 FKKYLVKLKSI-------NPP------------CVPFFGIYLTNILKTEEGNNDFLKKKG 950
Query: 414 ----NTNKRSKEVRVLQEMQLLQVAAMNYRLRP-LEKFVTYFTRMEQLSDKE----SYKL 464
N +KR K + E+Q Q R+ P + +F M S+KE +
Sbjct: 951 KDLINFSKRRKVAEITGEIQQYQNQPYCLRIEPDMRRFFENLNPMGSASEKEFTDYLFNK 1010
Query: 465 SCQLEPEN 472
S ++EP N
Sbjct: 1011 SLEIEPRN 1018
>gi|47551356 hypothetical protein LOC408029 [Homo sapiens]
Length = 209
Score = 63.2 bits (152), Expect = 5e-10
Identities = 42/116 (36%), Positives = 48/116 (41%), Gaps = 30/116 (25%)
Query: 114 VLPEPNEAKPDDPAPRPGQHALTMPALEPAPPLLADLGPALEPESPAALGPPGYLHSAPG 173
V PE E P+ AP G P PA+EP
Sbjct: 3 VRPESGEQGPETLAPASGAEIQRFPV------------PAVEP----------------- 33
Query: 174 PAPAPGEGPPPGTVLEPQSAPESSCPCRGSVKNQPSEELPDMTTFPPRLLAEQLTL 229
PAPG PPGT LE + APE SC C G+ ++QPSEELPD P A L L
Sbjct: 34 -VPAPGADSPPGTALELEEAPEPSCRCPGTAQDQPSEELPDFMAPPVEPPASALEL 88
>gi|22749129 RasGEF domain family, member 1B [Homo sapiens]
Length = 473
Score = 62.8 bits (151), Expect = 7e-10
Identities = 42/145 (28%), Positives = 75/145 (51%), Gaps = 12/145 (8%)
Query: 204 VKNQPSEELPDMTTF--PPRLLAEQLTLMDAELFKKVVLHECLGCIWGQGHLKGNEHM-- 259
+K +P D+ T P LA+QLT ++ E + E + + L ++
Sbjct: 188 LKTKPQSIQRDIITVCNDPYTLAQQLTHIELERLNYIGPEEFVQAFVQKDPLDNDKSCYS 247
Query: 260 ----APTVRATIAHFNRLTNCITTS-CLGDHSMRARDRARVVEHWIKVARECLSLNNFSS 314
+ A + FNRL+ + T C+ ++ + RAR++E++I VAREC ++ NF+S
Sbjct: 248 ERKKTRNLEAYVEWFNRLSYLVATEICM---PVKKKHRARMIEYFIDVARECFNIGNFNS 304
Query: 315 VHVIVSALCSNPIGQLHKTWAGVSS 339
+ I+S + +P+ +L KTWA V +
Sbjct: 305 LMAIISGMNMSPVSRLKKTWAKVKT 329
>gi|47524184 hypothetical protein LOC29798 [Homo sapiens]
Length = 203
Score = 62.4 bits (150), Expect = 9e-10
Identities = 30/56 (53%), Positives = 34/56 (60%)
Query: 174 PAPAPGEGPPPGTVLEPQSAPESSCPCRGSVKNQPSEELPDMTTFPPRLLAEQLTL 229
P PAPG PPGT LE + APE SC C G+ ++QPSEELPD P A L L
Sbjct: 27 PVPAPGADSPPGTALELEEAPEPSCRCPGTAQDQPSEELPDFMAPPVEPPASALEL 82
>gi|169215684 PREDICTED: hypothetical protein [Homo sapiens]
Length = 283
Score = 61.6 bits (148), Expect = 1e-09
Identities = 45/118 (38%), Positives = 58/118 (49%), Gaps = 10/118 (8%)
Query: 114 VLPEPNEAKPDDPAPRPGQHALTMPALEPAPPLLADLGPALEPESPAALGPPGYLHSAPG 173
+ P+ A P PG H L + +P P L + + +PA+ G L P
Sbjct: 38 IRPQMELAGQASPVIPPGPH-LHIVLFQPEPLELIET----QAHAPAS-GAEIQLFPVPA 91
Query: 174 --PAPAPGEGPPPGTVLEPQSAPESSCPCRGSVKNQPSEELPDMTTFP--PRLLAEQL 227
P PAPG PPGT LE + APE S C G+ ++QPSEELPD P PR A +L
Sbjct: 92 VEPVPAPGADSPPGTALELEEAPEPSFCCPGTAQDQPSEELPDFMAPPVEPRASALEL 149
>gi|40255197 RasGEF domain family, member 1C [Homo sapiens]
Length = 466
Score = 61.2 bits (147), Expect = 2e-09
Identities = 38/123 (30%), Positives = 64/123 (52%), Gaps = 8/123 (6%)
Query: 220 PRLLAEQLTLMDAELFKKVVLHECLGCIWGQGHLKGNE----HMAPTVRATIAHFNRLTN 275
P LA+QLT ++ E + + E + + L + + A + FNRL
Sbjct: 201 PYTLAQQLTHVELERLRHIGPEEFVQAFVNKDPLASTKPCFSDKTSNLEAYVKWFNRLCY 260
Query: 276 CITTS-CLGDHSMRARDRARVVEHWIKVARECLSLNNFSSVHVIVSALCSNPIGQLHKTW 334
+ T C+ + + RA+V+E +I VAREC ++ NF+S+ I+S + +P+ +L KTW
Sbjct: 261 LVATEICM---PAKKKQRAQVIEFFIDVARECFNIGNFNSLMAIISGMNMSPVSRLKKTW 317
Query: 335 AGV 337
A V
Sbjct: 318 AKV 320
>gi|24797103 RAS guanyl releasing protein 2 [Homo sapiens]
Length = 609
Score = 60.8 bits (146), Expect = 3e-09
Identities = 69/260 (26%), Positives = 109/260 (41%), Gaps = 33/260 (12%)
Query: 220 PRLLAEQLTLMDAELFKKVVLHECLGCIWGQGHLKGNEHMAPTVRATIAHFNRLTNCITT 279
P LAE LT ++ F K++ + + G N P + I+ FN ++ +
Sbjct: 155 PMELAEHLTYLEYRSFCKILFQDYHSFVT-HGCTVDN----PVLERFISLFNSVSQWVQL 209
Query: 280 SCLGDHSMRARDRARVVEHWIKVARECLSLNNFSSVHVIVSALCSNPIGQLHKTWAGVSS 339
L + A RA V+ H++ VA + L L NF+++ +V L + I +L +T + VS
Sbjct: 210 MILSKPT--APQRALVITHFVHVAEKLLQLQNFNTLMAVVGGLSHSSISRLKETHSHVSP 267
Query: 340 KSMKELKELCKKDTAVKRDLLIKAGSFKVATQERNPQRVQMRLRRQKKGVVPFLGDFLTE 399
+++K + G ++ T N + RL P LG L +
Sbjct: 268 ETIK-----------------LWEGLTELVTATGNYGNYRRRLAACVGFRFPILGVHLKD 310
Query: 400 LQRLDSAIPDDLDGNTNKRSKEVRVLQEMQLLQVAAMNYRLRP-------LEKFVTYFTR 452
L L A+PD LD R ++ Q +L+ AM LRP L +T
Sbjct: 311 LVALQLALPDWLD-PARTRLNGAKMKQLFSILEELAMVTSLRPPVQANPDLLSLLTVSLD 369
Query: 453 MEQLSDKESYKLSCQLEPEN 472
Q D E Y+LS Q EP +
Sbjct: 370 QYQTED-ELYQLSLQREPRS 388
>gi|149158729 RAS guanyl releasing protein 2 [Homo sapiens]
Length = 609
Score = 60.8 bits (146), Expect = 3e-09
Identities = 69/260 (26%), Positives = 109/260 (41%), Gaps = 33/260 (12%)
Query: 220 PRLLAEQLTLMDAELFKKVVLHECLGCIWGQGHLKGNEHMAPTVRATIAHFNRLTNCITT 279
P LAE LT ++ F K++ + + G N P + I+ FN ++ +
Sbjct: 155 PMELAEHLTYLEYRSFCKILFQDYHSFVT-HGCTVDN----PVLERFISLFNSVSQWVQL 209
Query: 280 SCLGDHSMRARDRARVVEHWIKVARECLSLNNFSSVHVIVSALCSNPIGQLHKTWAGVSS 339
L + A RA V+ H++ VA + L L NF+++ +V L + I +L +T + VS
Sbjct: 210 MILSKPT--APQRALVITHFVHVAEKLLQLQNFNTLMAVVGGLSHSSISRLKETHSHVSP 267
Query: 340 KSMKELKELCKKDTAVKRDLLIKAGSFKVATQERNPQRVQMRLRRQKKGVVPFLGDFLTE 399
+++K + G ++ T N + RL P LG L +
Sbjct: 268 ETIK-----------------LWEGLTELVTATGNYGNYRRRLAACVGFRFPILGVHLKD 310
Query: 400 LQRLDSAIPDDLDGNTNKRSKEVRVLQEMQLLQVAAMNYRLRP-------LEKFVTYFTR 452
L L A+PD LD R ++ Q +L+ AM LRP L +T
Sbjct: 311 LVALQLALPDWLD-PARTRLNGAKMKQLFSILEELAMVTSLRPPVQANPDLLSLLTVSLD 369
Query: 453 MEQLSDKESYKLSCQLEPEN 472
Q D E Y+LS Q EP +
Sbjct: 370 QYQTED-ELYQLSLQREPRS 388
>gi|149158727 RAS guanyl releasing protein 2 [Homo sapiens]
Length = 609
Score = 60.8 bits (146), Expect = 3e-09
Identities = 69/260 (26%), Positives = 109/260 (41%), Gaps = 33/260 (12%)
Query: 220 PRLLAEQLTLMDAELFKKVVLHECLGCIWGQGHLKGNEHMAPTVRATIAHFNRLTNCITT 279
P LAE LT ++ F K++ + + G N P + I+ FN ++ +
Sbjct: 155 PMELAEHLTYLEYRSFCKILFQDYHSFVT-HGCTVDN----PVLERFISLFNSVSQWVQL 209
Query: 280 SCLGDHSMRARDRARVVEHWIKVARECLSLNNFSSVHVIVSALCSNPIGQLHKTWAGVSS 339
L + A RA V+ H++ VA + L L NF+++ +V L + I +L +T + VS
Sbjct: 210 MILSKPT--APQRALVITHFVHVAEKLLQLQNFNTLMAVVGGLSHSSISRLKETHSHVSP 267
Query: 340 KSMKELKELCKKDTAVKRDLLIKAGSFKVATQERNPQRVQMRLRRQKKGVVPFLGDFLTE 399
+++K + G ++ T N + RL P LG L +
Sbjct: 268 ETIK-----------------LWEGLTELVTATGNYGNYRRRLAACVGFRFPILGVHLKD 310
Query: 400 LQRLDSAIPDDLDGNTNKRSKEVRVLQEMQLLQVAAMNYRLRP-------LEKFVTYFTR 452
L L A+PD LD R ++ Q +L+ AM LRP L +T
Sbjct: 311 LVALQLALPDWLD-PARTRLNGAKMKQLFSILEELAMVTSLRPPVQANPDLLSLLTVSLD 369
Query: 453 MEQLSDKESYKLSCQLEPEN 472
Q D E Y+LS Q EP +
Sbjct: 370 QYQTED-ELYQLSLQREPRS 388
>gi|89037235 PREDICTED: hypothetical protein [Homo sapiens]
Length = 130
Score = 59.7 bits (143), Expect = 6e-09
Identities = 36/74 (48%), Positives = 41/74 (55%), Gaps = 4/74 (5%)
Query: 158 SPAALGPPGYLHSAPG--PAPAPGEGPPPGTVLEPQSAPESSCPCRGSVKNQPSEELPDM 215
S AA G L P P PAPG PPGT LE + APE S C G+ ++QPSEELPD
Sbjct: 9 SAAASGAEIQLFPVPAVEPVPAPGADSPPGTALELEEAPEPSFCCPGTAQDQPSEELPDF 68
Query: 216 TTFP--PRLLAEQL 227
P PR A +L
Sbjct: 69 MAPPVEPRASALEL 82
>gi|239747182 PREDICTED: hypothetical protein XP_002343934 [Homo
sapiens]
Length = 130
Score = 58.2 bits (139), Expect = 2e-08
Identities = 30/56 (53%), Positives = 35/56 (62%), Gaps = 2/56 (3%)
Query: 174 PAPAPGEGPPPGTVLEPQSAPESSCPCRGSVKNQPSEELPDMTTFP--PRLLAEQL 227
P PAPG PPGT LE + APE S C G+ ++QPSEELPD P PR A +L
Sbjct: 27 PVPAPGADSPPGTALELEEAPEPSFCCPGTAQDQPSEELPDFMAPPVEPRASALEL 82
>gi|89058402 PREDICTED: hypothetical protein [Homo sapiens]
Length = 130
Score = 58.2 bits (139), Expect = 2e-08
Identities = 30/56 (53%), Positives = 35/56 (62%), Gaps = 2/56 (3%)
Query: 174 PAPAPGEGPPPGTVLEPQSAPESSCPCRGSVKNQPSEELPDMTTFP--PRLLAEQL 227
P PAPG PPGT LE + APE S C G+ ++QPSEELPD P PR A +L
Sbjct: 27 PVPAPGADSPPGTALELEEAPEPSFCCPGTAQDQPSEELPDFMAPPVEPRASALEL 82
>gi|117168263 RasGEF domain family, member 1A [Homo sapiens]
Length = 481
Score = 56.2 bits (134), Expect = 6e-08
Identities = 45/186 (24%), Positives = 87/186 (46%), Gaps = 16/186 (8%)
Query: 220 PRLLAEQLTLMDAELFKKVVLHECLGCIWGQGHL-----KGNEHMAPTVRATIAHFNRLT 274
P +LA+QLT ++ + + + + + L +G+ ++ A FN L+
Sbjct: 215 PLVLAQQLTHIELDRVSSIYPEDLMQIVSHMDSLDNHRCRGDLTKTYSLEAYDNWFNCLS 274
Query: 275 NCITTSCLGDHSMRARDRARVVEHWIKVARECLSLNNFSSVHVIVSALCSNPIGQLHKTW 334
+ T ++ + R R++E +I VAREC ++ NF+S+ I+S + +P+ +L KTW
Sbjct: 275 MLVATEVC--RVVKKKHRTRMLEFFIDVARECFNIGNFNSMMAIISGMNLSPVARLKKTW 332
Query: 335 AGVSSKSMKELKELCKKDTAVKRDLLIKAGSFKVATQERNPQRVQMRLRRQKKGVVPFLG 394
+ V + L+ D +++ A Q QR QM ++K V+P
Sbjct: 333 SKVKTAKFDVLEH--------HMDPSSNFCNYRTALQGAT-QRSQMANSSREKIVIPVFN 383
Query: 395 DFLTEL 400
F+ ++
Sbjct: 384 LFVKDI 389
>gi|54633319 PDZ domain-containing guanine nucleotide exchange
factor I [Homo sapiens]
Length = 1601
Score = 52.0 bits (123), Expect = 1e-06
Identities = 34/128 (26%), Positives = 60/128 (46%), Gaps = 10/128 (7%)
Query: 223 LAEQLTLMDAELFKKVVLHECLGCIWGQGHLKGNEHMAPTVRATIAHFNRLTNCITTSCL 282
+A QL++ D +LF+ + E + ++ GN H+ F + N T
Sbjct: 864 VATQLSMRDFDLFRNIEPTEYIDDLFKLNSKTGNTHLK--------RFEDIVNQETFWVA 915
Query: 283 GDHSMRARD--RARVVEHWIKVARECLSLNNFSSVHVIVSALCSNPIGQLHKTWAGVSSK 340
+ A R ++++H+IK+A C NF+S+ I+S L + +L TW + SK
Sbjct: 916 SEILTEANQLKRMKIIKHFIKIALHCRECKNFNSMFAIISGLNLASVARLRGTWEKLPSK 975
Query: 341 SMKELKEL 348
K L++L
Sbjct: 976 YEKHLQDL 983
Database: hs.faa
Posted date: Aug 4, 2009 4:42 PM
Number of letters in database: 18,247,518
Number of sequences in database: 37,866
Lambda K H
0.318 0.134 0.410
Gapped
Lambda K H
0.267 0.0410 0.140
Matrix: BLOSUM62
Gap Penalties: Existence: 11, Extension: 1
Number of Hits to DB: 22,109,852
Number of Sequences: 37866
Number of extensions: 1341812
Number of successful extensions: 15005
Number of sequences better than 10.0: 30
Number of HSP's better than 10.0 without gapping: 237
Number of HSP's successfully gapped in prelim test: 954
Number of HSP's that attempted gapping in prelim test: 8869
Number of HSP's gapped (non-prelim): 4887
length of query: 473
length of database: 18,247,518
effective HSP length: 106
effective length of query: 367
effective length of database: 14,233,722
effective search space: 5223775974
effective search space used: 5223775974
T: 11
A: 40
X1: 16 ( 7.3 bits)
X2: 38 (14.6 bits)
X3: 64 (24.7 bits)
S1: 41 (21.7 bits)
S2: 64 (29.3 bits)
Search results were obtained with NCBI BLAST and RefSeq entries.
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Guide to the Human Genome
Copyright © 2010 by Stewart Scherer. All rights reserved.