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Search of human proteins with 239050813
BLASTP 2.2.11 [Jun-05-2005]
Reference: Altschul, Stephen F., Thomas L. Madden, Alejandro A. Schaffer,
Jinghui Zhang, Zheng Zhang, Webb Miller, and David J. Lipman (1997),
"Gapped BLAST and PSI-BLAST: a new generation of protein database search
programs", Nucleic Acids Res. 25:3389-3402.
Query= gi|239050813 lipoxygenase homology domains 1 isoform 1 [Homo
sapiens]
(2211 letters)
Database: hs.faa
37,866 sequences; 18,247,518 total letters
Searching..................................................done
Score E
Sequences producing significant alignments: (bits) Value
gi|239050813 lipoxygenase homology domains 1 isoform 1 [Homo sap... 4535 0.0
gi|224458288 lipoxygenase homology domains 1 isoform 2 [Homo sap... 2073 0.0
gi|224458290 lipoxygenase homology domains 1 isoform 3 [Homo sap... 1060 0.0
gi|239754889 PREDICTED: similar to hCG2036697 [Homo sapiens] 127 1e-28
gi|239749428 PREDICTED: hypothetical protein XP_002347033 [Homo ... 127 1e-28
gi|239743562 PREDICTED: hypothetical protein XP_002342894 [Homo ... 127 1e-28
gi|239756622 PREDICTED: polycystic kidney disease 1-like 3 [Homo... 81 1e-14
gi|239751108 PREDICTED: polycystic kidney disease 1-like 3 [Homo... 81 1e-14
gi|239745596 PREDICTED: polycystin 1-like 3 [Homo sapiens] 81 1e-14
gi|31559825 polycystin 1-like 3 [Homo sapiens] 81 1e-14
gi|19923084 polycystin-1L1 [Homo sapiens] 79 4e-14
gi|205360962 polycystin 1 isoform 2 precursor [Homo sapiens] 78 8e-14
gi|205360954 polycystin 1 isoform 1 precursor [Homo sapiens] 78 8e-14
gi|116006951 polycystin 1-like 2 isoform a [Homo sapiens] 76 3e-13
gi|5174633 receptor for egg jelly-like protein precursor [Homo s... 70 3e-11
gi|122891862 DENN/MADD domain containing 5B [Homo sapiens] 66 4e-10
gi|44889475 RAB6 interacting protein 1 [Homo sapiens] 64 2e-09
gi|221219020 NYD-SP11 protein [Homo sapiens] 59 4e-08
gi|4502057 arachidonate 5-lipoxygenase [Homo sapiens] 59 4e-08
gi|239508778 PREDICTED: hypothetical protein, partial [Homo sapi... 58 1e-07
gi|17975763 myelin transcription factor 1 [Homo sapiens] 57 2e-07
gi|46276863 parathymosin [Homo sapiens] 56 3e-07
gi|148763345 cell division cycle 2-like 2 isoform 4 [Homo sapiens] 54 2e-06
gi|148763347 cell division cycle 2-like 2 isoform 1 [Homo sapiens] 54 2e-06
gi|16332372 cell division cycle 2-like 1 (PITSLRE proteins) isof... 54 2e-06
gi|16332370 cell division cycle 2-like 1 (PITSLRE proteins) isof... 54 2e-06
gi|16332364 cell division cycle 2-like 1 (PITSLRE proteins) isof... 54 2e-06
gi|16332362 cell division cycle 2-like 1 (PITSLRE proteins) isof... 54 2e-06
gi|16332358 cell division cycle 2-like 1 (PITSLRE proteins) isof... 54 2e-06
gi|78190492 retinitis pigmentosa GTPase regulator isoform C [Hom... 52 5e-06
>gi|239050813 lipoxygenase homology domains 1 isoform 1 [Homo sapiens]
Length = 2211
Score = 4535 bits (11762), Expect = 0.0
Identities = 2211/2211 (100%), Positives = 2211/2211 (100%)
Query: 1 MMPQKKRRRKKDIDFLALYEAELLNYASEDDEGELEHEYYKARVYEVVTATGDVRGAGTD 60
MMPQKKRRRKKDIDFLALYEAELLNYASEDDEGELEHEYYKARVYEVVTATGDVRGAGTD
Sbjct: 1 MMPQKKRRRKKDIDFLALYEAELLNYASEDDEGELEHEYYKARVYEVVTATGDVRGAGTD 60
Query: 61 ANVFITLFGENGLSPKLQLTSKSKSAFEKGNVDVFRVRTNNVGLIYKVRIEHDNTGLNAS 120
ANVFITLFGENGLSPKLQLTSKSKSAFEKGNVDVFRVRTNNVGLIYKVRIEHDNTGLNAS
Sbjct: 61 ANVFITLFGENGLSPKLQLTSKSKSAFEKGNVDVFRVRTNNVGLIYKVRIEHDNTGLNAS 120
Query: 121 WYLDHVIVTDMKRPHLRYYFNCNNWLSKVEGDRQWCRDLLASFNPMDMPRGNKYEVKVYT 180
WYLDHVIVTDMKRPHLRYYFNCNNWLSKVEGDRQWCRDLLASFNPMDMPRGNKYEVKVYT
Sbjct: 121 WYLDHVIVTDMKRPHLRYYFNCNNWLSKVEGDRQWCRDLLASFNPMDMPRGNKYEVKVYT 180
Query: 181 GDVIGAGTDADVFINIFGEYGDTGERRLENEKDNFEKGAEDRFILDAPDLGQLMKINVGH 240
GDVIGAGTDADVFINIFGEYGDTGERRLENEKDNFEKGAEDRFILDAPDLGQLMKINVGH
Sbjct: 181 GDVIGAGTDADVFINIFGEYGDTGERRLENEKDNFEKGAEDRFILDAPDLGQLMKINVGH 240
Query: 241 NNKGGSAGWFLSQIVIEDIGNKRKYDFPLNRWLALDEDDGKIQRDILVGGAETTAITYIV 300
NNKGGSAGWFLSQIVIEDIGNKRKYDFPLNRWLALDEDDGKIQRDILVGGAETTAITYIV
Sbjct: 241 NNKGGSAGWFLSQIVIEDIGNKRKYDFPLNRWLALDEDDGKIQRDILVGGAETTAITYIV 300
Query: 301 TVFTGDVRGAGTKSKIYLVMYGARGNKNSGKIFLEGGVFDRGRTDIFHIELAVLLSPLSR 360
TVFTGDVRGAGTKSKIYLVMYGARGNKNSGKIFLEGGVFDRGRTDIFHIELAVLLSPLSR
Sbjct: 301 TVFTGDVRGAGTKSKIYLVMYGARGNKNSGKIFLEGGVFDRGRTDIFHIELAVLLSPLSR 360
Query: 361 VSVGHGNVGVNRGWFCEKVVILCPFTGIQQTFPCSNWLDEKKADGLIERQLYEMVSLRKK 420
VSVGHGNVGVNRGWFCEKVVILCPFTGIQQTFPCSNWLDEKKADGLIERQLYEMVSLRKK
Sbjct: 361 VSVGHGNVGVNRGWFCEKVVILCPFTGIQQTFPCSNWLDEKKADGLIERQLYEMVSLRKK 420
Query: 421 RLKKFPWSLWVWTTDLKKAGTNSPIFIQIYGQKGRTDEILLNPNNKWFKPGIIEKFRIEL 480
RLKKFPWSLWVWTTDLKKAGTNSPIFIQIYGQKGRTDEILLNPNNKWFKPGIIEKFRIEL
Sbjct: 421 RLKKFPWSLWVWTTDLKKAGTNSPIFIQIYGQKGRTDEILLNPNNKWFKPGIIEKFRIEL 480
Query: 481 PDLGRFYKIRVWHDKRSSGSGWHLERMTLMNTLNKDKYNFNCNRWLDANEDDNEIVREMT 540
PDLGRFYKIRVWHDKRSSGSGWHLERMTLMNTLNKDKYNFNCNRWLDANEDDNEIVREMT
Sbjct: 481 PDLGRFYKIRVWHDKRSSGSGWHLERMTLMNTLNKDKYNFNCNRWLDANEDDNEIVREMT 540
Query: 541 AEGPTVRRIMGMARYHVTVCTGELEGAGTDANVYLCLFGDVGDTGERLLYNCRNNTDLFE 600
AEGPTVRRIMGMARYHVTVCTGELEGAGTDANVYLCLFGDVGDTGERLLYNCRNNTDLFE
Sbjct: 541 AEGPTVRRIMGMARYHVTVCTGELEGAGTDANVYLCLFGDVGDTGERLLYNCRNNTDLFE 600
Query: 601 KGNADEFTIESVTMRNVRRVRIRHDGKGSGSGWYLDRVLVREEGQPESDNVEFPCLRWLD 660
KGNADEFTIESVTMRNVRRVRIRHDGKGSGSGWYLDRVLVREEGQPESDNVEFPCLRWLD
Sbjct: 601 KGNADEFTIESVTMRNVRRVRIRHDGKGSGSGWYLDRVLVREEGQPESDNVEFPCLRWLD 660
Query: 661 KDKDDGQLVRELLPSDSSATLKNFRYHISLKTGDVSGASTDSRVYIKLYGDKSDTIKQVL 720
KDKDDGQLVRELLPSDSSATLKNFRYHISLKTGDVSGASTDSRVYIKLYGDKSDTIKQVL
Sbjct: 661 KDKDDGQLVRELLPSDSSATLKNFRYHISLKTGDVSGASTDSRVYIKLYGDKSDTIKQVL 720
Query: 721 LVSDNNLKDYFERGRVDEFTLETLNIGNINRLVIGHDSTGMHASWFLGSVQIRVPRQGKQ 780
LVSDNNLKDYFERGRVDEFTLETLNIGNINRLVIGHDSTGMHASWFLGSVQIRVPRQGKQ
Sbjct: 721 LVSDNNLKDYFERGRVDEFTLETLNIGNINRLVIGHDSTGMHASWFLGSVQIRVPRQGKQ 780
Query: 781 YTFPANRWLDKNQADGRLEVELYPSEVVEIQKLVHYEVEIWTGDVGGAGTSARVYMQIYG 840
YTFPANRWLDKNQADGRLEVELYPSEVVEIQKLVHYEVEIWTGDVGGAGTSARVYMQIYG
Sbjct: 781 YTFPANRWLDKNQADGRLEVELYPSEVVEIQKLVHYEVEIWTGDVGGAGTSARVYMQIYG 840
Query: 841 EKGKTEVLFLSSRSKVFERASKDTFQLEAADVGEVYKLRLGHTGEGFGPSWFVDTVWLRH 900
EKGKTEVLFLSSRSKVFERASKDTFQLEAADVGEVYKLRLGHTGEGFGPSWFVDTVWLRH
Sbjct: 841 EKGKTEVLFLSSRSKVFERASKDTFQLEAADVGEVYKLRLGHTGEGFGPSWFVDTVWLRH 900
Query: 901 LVVREVDLTPEEEARKKKEKDKLRQLLKKERLKAKLQRKKKKRKGSDEEDEGEEEESSSS 960
LVVREVDLTPEEEARKKKEKDKLRQLLKKERLKAKLQRKKKKRKGSDEEDEGEEEESSSS
Sbjct: 901 LVVREVDLTPEEEARKKKEKDKLRQLLKKERLKAKLQRKKKKRKGSDEEDEGEEEESSSS 960
Query: 961 EESSSEEEEMEEEEEEEEFGPGMQEVIEQHKFEAHRWLARGKEDNELVVELVPAGKPGPE 1020
EESSSEEEEMEEEEEEEEFGPGMQEVIEQHKFEAHRWLARGKEDNELVVELVPAGKPGPE
Sbjct: 961 EESSSEEEEMEEEEEEEEFGPGMQEVIEQHKFEAHRWLARGKEDNELVVELVPAGKPGPE 1020
Query: 1021 RNTYEVQVVTGNVPKAGTDANVYLTIYGEEYGDTGERPLKKSDKSNKFEQGQTDTFTIYA 1080
RNTYEVQVVTGNVPKAGTDANVYLTIYGEEYGDTGERPLKKSDKSNKFEQGQTDTFTIYA
Sbjct: 1021 RNTYEVQVVTGNVPKAGTDANVYLTIYGEEYGDTGERPLKKSDKSNKFEQGQTDTFTIYA 1080
Query: 1081 IDLGALTKIRIRHDNTGNRAGWFLDRIDITDMNNEITYYFPCQRWLAVEEDDGQLSRELL 1140
IDLGALTKIRIRHDNTGNRAGWFLDRIDITDMNNEITYYFPCQRWLAVEEDDGQLSRELL
Sbjct: 1081 IDLGALTKIRIRHDNTGNRAGWFLDRIDITDMNNEITYYFPCQRWLAVEEDDGQLSRELL 1140
Query: 1141 PVDESYVLPQSEEGRGGGDNNPLDNLALEQKDKSTTFSVTIKTGVKKNAGTDANVFITLF 1200
PVDESYVLPQSEEGRGGGDNNPLDNLALEQKDKSTTFSVTIKTGVKKNAGTDANVFITLF
Sbjct: 1141 PVDESYVLPQSEEGRGGGDNNPLDNLALEQKDKSTTFSVTIKTGVKKNAGTDANVFITLF 1200
Query: 1201 GTQDDTGMTLLKSSKTNSDKFERDSIEIFTVETLDLGDLWKVRLGHDNTGKAPGWFVDWV 1260
GTQDDTGMTLLKSSKTNSDKFERDSIEIFTVETLDLGDLWKVRLGHDNTGKAPGWFVDWV
Sbjct: 1201 GTQDDTGMTLLKSSKTNSDKFERDSIEIFTVETLDLGDLWKVRLGHDNTGKAPGWFVDWV 1260
Query: 1261 EVDAPSLGKCMTFPCGRWLAKNEDDGSIIRDLFHAELQTRLYTPFVPYEITLYTSDVFAA 1320
EVDAPSLGKCMTFPCGRWLAKNEDDGSIIRDLFHAELQTRLYTPFVPYEITLYTSDVFAA
Sbjct: 1261 EVDAPSLGKCMTFPCGRWLAKNEDDGSIIRDLFHAELQTRLYTPFVPYEITLYTSDVFAA 1320
Query: 1321 GTDANIFIIIYGCDAVCTQQKYLCTNKREQKQFFERKSASRFIVELEDVGEIIEKIRIGH 1380
GTDANIFIIIYGCDAVCTQQKYLCTNKREQKQFFERKSASRFIVELEDVGEIIEKIRIGH
Sbjct: 1321 GTDANIFIIIYGCDAVCTQQKYLCTNKREQKQFFERKSASRFIVELEDVGEIIEKIRIGH 1380
Query: 1381 NNTGMNPGWHCSHVDIRRLLPDKDGAETLTFPCDRWLATSEDDKKTIRELVPYDIFTEKY 1440
NNTGMNPGWHCSHVDIRRLLPDKDGAETLTFPCDRWLATSEDDKKTIRELVPYDIFTEKY
Sbjct: 1381 NNTGMNPGWHCSHVDIRRLLPDKDGAETLTFPCDRWLATSEDDKKTIRELVPYDIFTEKY 1440
Query: 1441 MKDGSLRQVYKEVEEPLDIVLYSVQIFTGNIPGAGTDAKVYITIYGDLGDTGERYLGKSE 1500
MKDGSLRQVYKEVEEPLDIVLYSVQIFTGNIPGAGTDAKVYITIYGDLGDTGERYLGKSE
Sbjct: 1441 MKDGSLRQVYKEVEEPLDIVLYSVQIFTGNIPGAGTDAKVYITIYGDLGDTGERYLGKSE 1500
Query: 1501 NRTNKFERGTADTFIIEAADLGVIYKIKLRHDNSKWCADWYVEKVEIWNDTNEDEFLFLC 1560
NRTNKFERGTADTFIIEAADLGVIYKIKLRHDNSKWCADWYVEKVEIWNDTNEDEFLFLC
Sbjct: 1501 NRTNKFERGTADTFIIEAADLGVIYKIKLRHDNSKWCADWYVEKVEIWNDTNEDEFLFLC 1560
Query: 1561 GRWLSLKKEDGRLERLFYEKEYTGDRSSNCSSPADFWEIALSSKMADVDISTVTGPMADY 1620
GRWLSLKKEDGRLERLFYEKEYTGDRSSNCSSPADFWEIALSSKMADVDISTVTGPMADY
Sbjct: 1561 GRWLSLKKEDGRLERLFYEKEYTGDRSSNCSSPADFWEIALSSKMADVDISTVTGPMADY 1620
Query: 1621 VQEGPIIPYYVSVTTGKHKDAATDSRAFIFLIGEDDERSKRIWLDYPRGKRGFSRGSVEE 1680
VQEGPIIPYYVSVTTGKHKDAATDSRAFIFLIGEDDERSKRIWLDYPRGKRGFSRGSVEE
Sbjct: 1621 VQEGPIIPYYVSVTTGKHKDAATDSRAFIFLIGEDDERSKRIWLDYPRGKRGFSRGSVEE 1680
Query: 1681 FYVAGLDVGIIKKIEVLYEMTVWTGDVVGGGTDSNIFMTLYGINGSTEEMQLDKKKARFE 1740
FYVAGLDVGIIKKIEVLYEMTVWTGDVVGGGTDSNIFMTLYGINGSTEEMQLDKKKARFE
Sbjct: 1681 FYVAGLDVGIIKKIEVLYEMTVWTGDVVGGGTDSNIFMTLYGINGSTEEMQLDKKKARFE 1740
Query: 1741 REQNDTFIMEILDIAPFTKMRIRIDGLGSRPEWFLERILLKNMNTGDLTMFYYGDWLSQR 1800
REQNDTFIMEILDIAPFTKMRIRIDGLGSRPEWFLERILLKNMNTGDLTMFYYGDWLSQR
Sbjct: 1741 REQNDTFIMEILDIAPFTKMRIRIDGLGSRPEWFLERILLKNMNTGDLTMFYYGDWLSQR 1800
Query: 1801 KGKKTLVCEMCAVIDEEEMMEWTSYTVAVKTSDILGAGTDANVFIIIFGENGDSGTLALK 1860
KGKKTLVCEMCAVIDEEEMMEWTSYTVAVKTSDILGAGTDANVFIIIFGENGDSGTLALK
Sbjct: 1801 KGKKTLVCEMCAVIDEEEMMEWTSYTVAVKTSDILGAGTDANVFIIIFGENGDSGTLALK 1860
Query: 1861 QSANWNKFERNNTDTFNFPDMLSLGHLCKLRVWHDNKGIFPGWHLSYVDVKDNSRDETFH 1920
QSANWNKFERNNTDTFNFPDMLSLGHLCKLRVWHDNKGIFPGWHLSYVDVKDNSRDETFH
Sbjct: 1861 QSANWNKFERNNTDTFNFPDMLSLGHLCKLRVWHDNKGIFPGWHLSYVDVKDNSRDETFH 1920
Query: 1921 FQCDCWLSKSEGDGQTVRDFACANNKICDELEETTYEIVIETGNGGETRENVWLILEGRK 1980
FQCDCWLSKSEGDGQTVRDFACANNKICDELEETTYEIVIETGNGGETRENVWLILEGRK
Sbjct: 1921 FQCDCWLSKSEGDGQTVRDFACANNKICDELEETTYEIVIETGNGGETRENVWLILEGRK 1980
Query: 1981 NRSKEFLMENSSRQRAFRKGTTDTFEFDSIYLGDIASLCVGHLAREDRFIPKRELAWHVK 2040
NRSKEFLMENSSRQRAFRKGTTDTFEFDSIYLGDIASLCVGHLAREDRFIPKRELAWHVK
Sbjct: 1981 NRSKEFLMENSSRQRAFRKGTTDTFEFDSIYLGDIASLCVGHLAREDRFIPKRELAWHVK 2040
Query: 2041 TITITEMEYGNVYFFNCDCLIPLKRKRKYFKVFEVTKTTESFASKVQSLVPVKYEVIVTT 2100
TITITEMEYGNVYFFNCDCLIPLKRKRKYFKVFEVTKTTESFASKVQSLVPVKYEVIVTT
Sbjct: 2041 TITITEMEYGNVYFFNCDCLIPLKRKRKYFKVFEVTKTTESFASKVQSLVPVKYEVIVTT 2100
Query: 2101 GYEPGAGTDANVFVTIFGANGDTGKRELKQKMRNLFERGSTDRFFLETLELGELRKVRLE 2160
GYEPGAGTDANVFVTIFGANGDTGKRELKQKMRNLFERGSTDRFFLETLELGELRKVRLE
Sbjct: 2101 GYEPGAGTDANVFVTIFGANGDTGKRELKQKMRNLFERGSTDRFFLETLELGELRKVRLE 2160
Query: 2161 HDSSGYCSGWLVEKVEVTNTSTGVATIFNCGRWLDKKRGDGLTWRDLFPSV 2211
HDSSGYCSGWLVEKVEVTNTSTGVATIFNCGRWLDKKRGDGLTWRDLFPSV
Sbjct: 2161 HDSSGYCSGWLVEKVEVTNTSTGVATIFNCGRWLDKKRGDGLTWRDLFPSV 2211
>gi|224458288 lipoxygenase homology domains 1 isoform 2 [Homo sapiens]
Length = 1114
Score = 2073 bits (5372), Expect = 0.0
Identities = 1023/1102 (92%), Positives = 1026/1102 (93%), Gaps = 62/1102 (5%)
Query: 1112 MNNEITYYFPCQRWLAVEEDDGQLSRELLPVDESYVLPQSEEGRGGGDNNPLDNLALEQK 1171
MNNEITYYFPCQRWLAVEEDDGQLSRELLPVDESYVLPQSEEGRGGGDNNPLDNLALEQK
Sbjct: 1 MNNEITYYFPCQRWLAVEEDDGQLSRELLPVDESYVLPQSEEGRGGGDNNPLDNLALEQK 60
Query: 1172 DKSTTFSVTIKTGVKKNAGTDANVFITLFGTQDDTGMTLLKSSKTNSDKFERDSIEIFTV 1231
DKSTTFSVTIKTGVKKNAGTDANVFITLFGTQDDTGMTLLKSSKTNSDKFERDSIEIFTV
Sbjct: 61 DKSTTFSVTIKTGVKKNAGTDANVFITLFGTQDDTGMTLLKSSKTNSDKFERDSIEIFTV 120
Query: 1232 ETLDLGDLWKVRLGHDNTGKAPGWFVDWVEVDAPSLGKCMTFPCGRWLAKNEDDGSIIRD 1291
ETLDLGDLWKVRLGHDNTGKAPGWFVDWVEVDAPSLGKCMTFPCGRWLAKNEDDGSIIRD
Sbjct: 121 ETLDLGDLWKVRLGHDNTGKAPGWFVDWVEVDAPSLGKCMTFPCGRWLAKNEDDGSIIRD 180
Query: 1292 LFHAELQTRLYTPFVPYEITLYTSDVFAAGTDANIFIIIYGCDAVCTQQKYLCTNKREQK 1351
LFHAELQTRLYTPFVPYEITLYTSDVFAAGTDANIFIIIYGCDAVCTQQKYLCTNKREQK
Sbjct: 181 LFHAELQTRLYTPFVPYEITLYTSDVFAAGTDANIFIIIYGCDAVCTQQKYLCTNKREQK 240
Query: 1352 QFFERKSASRFIVELEDVGEIIEKIRIGHNNTGMNPGWHCSHVDIRRLLPDKDGAETLTF 1411
QFFERKSASRFIVELEDVGEIIEKIRIGHNNTGMNPGWHCSHVDIRRLLPDKDGAETLTF
Sbjct: 241 QFFERKSASRFIVELEDVGEIIEKIRIGHNNTGMNPGWHCSHVDIRRLLPDKDGAETLTF 300
Query: 1412 PCDRWLATSEDDKKTIRELVPYDIFTEKYMKDGSLRQVYKEVEEPLDIVLYSVQIFTGNI 1471
PCDRWLATSEDDKKTIRELVPYDIFTEKYMKDGSLRQVYKEVEEPLDIVLYSVQIFTGNI
Sbjct: 301 PCDRWLATSEDDKKTIRELVPYDIFTEKYMKDGSLRQVYKEVEEPLDIVLYSVQIFTGNI 360
Query: 1472 PGAGTDAKVYITIYGDLGDTGERYLGKSENRTNKFERGTADTFIIEAADLGVIYKIKLRH 1531
PGAGTDAKVYITIYGDLGDTGERYLGKSENRTNKFERGTADTFIIEAADLGVIYKIKLRH
Sbjct: 361 PGAGTDAKVYITIYGDLGDTGERYLGKSENRTNKFERGTADTFIIEAADLGVIYKIKLRH 420
Query: 1532 DNSKWCADWYVEKVEIWNDTNEDEFLFLCGRWLSLKKEDGRLERLFYEKEYTGDRSSNCS 1591
DNSKWCADWYVEKVEIWNDTNEDEFLFLCGRWLSLKKEDGRLERLFYEKEYTGDRSSNCS
Sbjct: 421 DNSKWCADWYVEKVEIWNDTNEDEFLFLCGRWLSLKKEDGRLERLFYEKEYTGDRSSNCS 480
Query: 1592 SPADFWEIALSSKMADVDISTVTGPMADYVQEGPIIPYYVSVTTGKHKDAATDSRAFIFL 1651
SPADFWEIALSSKMADVDISTVTGPMADYVQEGPIIPYYVSVTTGKHKDAATDSRAFIFL
Sbjct: 481 SPADFWEIALSSKMADVDISTVTGPMADYVQEGPIIPYYVSVTTGKHKDAATDSRAFIFL 540
Query: 1652 IGEDDERSKRIWLDYPRGKRGFSRGSVEEFYVAGLDVGIIKKIEV--------------- 1696
IGEDDERSKRIWLDYPRGKRGFSRGSVEEFYVAGLDVGIIKKIE+
Sbjct: 541 IGEDDERSKRIWLDYPRGKRGFSRGSVEEFYVAGLDVGIIKKIELGHDGASPESCWLVEE 600
Query: 1697 ------------LYEMTVWTGDVVGGGTDSNIF--------------------------- 1717
+ W G G S +F
Sbjct: 601 LCLAVPTQGTKYMLNCNCWLAKDRGDGITSRVFDLLDAMVVNIGVKVLYEMTVWTGDVVG 660
Query: 1718 --------MTLYGINGSTEEMQLDKKKARFEREQNDTFIMEILDIAPFTKMRIRIDGLGS 1769
MTLYGINGSTEEMQLDKKKARFEREQNDTFIMEILDIAPFTKMRIRIDGLGS
Sbjct: 661 GGTDSNIFMTLYGINGSTEEMQLDKKKARFEREQNDTFIMEILDIAPFTKMRIRIDGLGS 720
Query: 1770 RPEWFLERILLKNMNTGDLTMFYYGDWLSQRKGKKTLVCEMCAVIDEEEMMEWTSYTVAV 1829
RPEWFLERILLKNMNTGDLTMFYYGDWLSQRKGKKTLVCEMCAVIDEEEMMEWTSYTVAV
Sbjct: 721 RPEWFLERILLKNMNTGDLTMFYYGDWLSQRKGKKTLVCEMCAVIDEEEMMEWTSYTVAV 780
Query: 1830 KTSDILGAGTDANVFIIIFGENGDSGTLALKQSANWNKFERNNTDTFNFPDMLSLGHLCK 1889
KTSDILGAGTDANVFIIIFGENGDSGTLALKQSANWNKFERNNTDTFNFPDMLSLGHLCK
Sbjct: 781 KTSDILGAGTDANVFIIIFGENGDSGTLALKQSANWNKFERNNTDTFNFPDMLSLGHLCK 840
Query: 1890 LRVWHDNKGIFPGWHLSYVDVKDNSRDETFHFQCDCWLSKSEGDGQTVRDFACANNKICD 1949
LRVWHDNKGIFPGWHLSYVDVKDNSRDETFHFQCDCWLSKSEGDGQTVRDFACANNKICD
Sbjct: 841 LRVWHDNKGIFPGWHLSYVDVKDNSRDETFHFQCDCWLSKSEGDGQTVRDFACANNKICD 900
Query: 1950 ELEETTYEIVIETGNGGETRENVWLILEGRKNRSKEFLMENSSRQRAFRKGTTDTFEFDS 2009
ELEETTYEIVIETGNGGETRENVWLILEGRKNRSKEFLMENSSRQRAFRKGTTDTFEFDS
Sbjct: 901 ELEETTYEIVIETGNGGETRENVWLILEGRKNRSKEFLMENSSRQRAFRKGTTDTFEFDS 960
Query: 2010 IYLGDIASLCVGHLAREDRFIPKRELAWHVKTITITEMEYGNVYFFNCDCLIPLKRKRKY 2069
IYLGDIASLCVGHLAREDRFIPKRELAWHVKTITITEMEYGNVYFFNCDCLIPLKRKRKY
Sbjct: 961 IYLGDIASLCVGHLAREDRFIPKRELAWHVKTITITEMEYGNVYFFNCDCLIPLKRKRKY 1020
Query: 2070 FKVFEVTKTTESFASKVQSLVPVKYEVIVTTGYEPGAGTDANVFVTIFGANGDTGKRELK 2129
FKVFEVTKTTESFASKVQSLVPVKYEVIVTTGYEPGAGTDANVFVTIFGANGDTGKRELK
Sbjct: 1021 FKVFEVTKTTESFASKVQSLVPVKYEVIVTTGYEPGAGTDANVFVTIFGANGDTGKRELK 1080
Query: 2130 QKMRNLFERGSTDRFFLETLEL 2151
QKMRNLFERGSTDRFFLETLEL
Sbjct: 1081 QKMRNLFERGSTDRFFLETLEL 1102
Score = 423 bits (1088), Expect = e-118
Identities = 336/1240 (27%), Positives = 556/1240 (44%), Gaps = 197/1240 (15%)
Query: 514 NKDKYNFNCNRWLDANEDDNEIVREM-----------TAEGP-----------TVRRIMG 551
N+ Y F C RWL EDD ++ RE+ + EG + +
Sbjct: 3 NEITYYFPCQRWLAVEEDDGQLSRELLPVDESYVLPQSEEGRGGGDNNPLDNLALEQKDK 62
Query: 552 MARYHVTVCTGELEGAGTDANVYLCLFGDVGDTGERLLYNCRNNTDLFEKGNADEFTIES 611
+ VT+ TG + AGTDANV++ LFG DTG LL + + N+D FE+ + + FT+E+
Sbjct: 63 STTFSVTIKTGVKKNAGTDANVFITLFGTQDDTGMTLLKSSKTNSDKFERDSIEIFTVET 122
Query: 612 VTMRNVRRVRIRHDGKGSGSGWYLDRVLVREEGQPESDNVEFPCLRWLDKDKDDGQLVRE 671
+ + ++ +VR+ HD G GW++D V V + + FPC RWL K++DDG ++R+
Sbjct: 123 LDLGDLWKVRLGHDNTGKAPGWFVDWVEV--DAPSLGKCMTFPCGRWLAKNEDDGSIIRD 180
Query: 672 LLPSDSSATLKN--FRYHISLKTGDVSGASTDSRVYIKLYG-DKSDTIKQVLLVSDNNLK 728
L ++ L Y I+L T DV A TD+ ++I +YG D T ++ L + K
Sbjct: 181 LFHAELQTRLYTPFVPYEITLYTSDVFAAGTDANIFIIIYGCDAVCTQQKYLCTNKREQK 240
Query: 729 DYFERGRVDEFTLETLNIGNI-NRLVIGHDSTGMHASWFLGSVQIR--VPRQ--GKQYTF 783
+FER F +E ++G I ++ IGH++TGM+ W V IR +P + + TF
Sbjct: 241 QFFERKSASRFIVELEDVGEIIEKIRIGHNNTGMNPGWHCSHVDIRRLLPDKDGAETLTF 300
Query: 784 PANRWLDKNQADGRLEVELYP------------------SEVVEIQKLVHYEVEIWTGDV 825
P +RWL ++ D + EL P EV E +V Y V+I+TG++
Sbjct: 301 PCDRWLATSEDDKKTIRELVPYDIFTEKYMKDGSLRQVYKEVEEPLDIVLYSVQIFTGNI 360
Query: 826 GGAGTSARVYMQIYGEKGKTEVLFLS---SRSKVFERASKDTFQLEAADVGEVYKLRLGH 882
GAGT A+VY+ IYG+ G T +L +R+ FER + DTF +EAAD+G +YK++L H
Sbjct: 361 PGAGTDAKVYITIYGDLGDTGERYLGKSENRTNKFERGTADTFIIEAADLGVIYKIKLRH 420
Query: 883 TGEGFGPSWFVDTVWLRHLVVREVDLTPEEEARKKKEKDKLRQLLKKERLKAKLQRKKKK 942
+ W+V+ V E +D+ L + L K + + +
Sbjct: 421 DNSKWCADWYVEKV----------------EIWNDTNEDEFLFLCGRW-LSLKKEDGRLE 463
Query: 943 RKGSDEEDEGEEEESSSSEESSSE---EEEMEEEEEEEEFGPGMQEVIEQHKFEAHRWLA 999
R ++E G+ + SS E +M + + GP M + +++
Sbjct: 464 RLFYEKEYTGDRSSNCSSPADFWEIALSSKMADVDISTVTGP-MADYVQEGP-------- 514
Query: 1000 RGKEDNELVVELVPAGKPGPERNTYEVQVVTGNVPKAGTDANVYLTIYGEEYGDTGERPL 1059
++P Y V V TG A TD+ ++ + GE+ + L
Sbjct: 515 -----------IIP----------YYVSVTTGKHKDAATDSRAFIFLIGEDDERSKRIWL 553
Query: 1060 KKSDKSNKFEQGQTDTFTIYAIDLGALTKIRIRHDNTGNRAGWFLDRIDITDMNNEITYY 1119
F +G + F + +D+G + KI + HD + W ++ + + Y
Sbjct: 554 DYPRGKRGFSRGSVEEFYVAGLDVGIIKKIELGHDGASPESCWLVEELCLAVPTQGTKYM 613
Query: 1120 FPCQRWLAVEEDDGQLSRELLPVDESYVLPQSEEGRGGGDNNPLDNLALEQKDKSTTFSV 1179
C WLA + DG SR +D V N+ ++ + +
Sbjct: 614 LNCNCWLAKDRGDGITSRVFDLLDAMVV-----------------NIGVK-----VLYEM 651
Query: 1180 TIKTGVKKNAGTDANVFITLFGTQDDTGMTLLKSSKTNSDKFERDSIEIFTVETLDLGDL 1239
T+ TG GTD+N+F+TL+G T L K +FER+ + F +E LD+
Sbjct: 652 TVWTGDVVGGGTDSNIFMTLYGINGSTEEMQLDKKKA---RFEREQNDTFIMEILDIAPF 708
Query: 1240 WKVRLGHDNTGKAPGWFVDWVEVDAPSLGKCMTFPCGRWLAKNEDDGSIIRDLFHAELQT 1299
K+R+ D G P WF++ + + + G F G WL++ + +++ ++ A +
Sbjct: 709 TKMRIRIDGLGSRPEWFLERILLKNMNTGDLTMFYYGDWLSQRKGKKTLVCEMC-AVIDE 767
Query: 1300 RLYTPFVPYEITLYTSDVFAAGTDANIFIIIYGCDAVCTQQKYLCTNKREQKQFFERKSA 1359
+ Y + + TSD+ AGTDAN+FIII+G + L + FER +
Sbjct: 768 EEMMEWTSYTVAVKTSDILGAGTDANVFIIIFGENG---DSGTLALKQSANWNKFERNNT 824
Query: 1360 SRF-IVELEDVGEIIEKIRIGHNNTGMNPGWHCSHVDIRRLLPDKDGAETLTFPCDRWLA 1418
F ++ +G + K+R+ H+N G+ PGWH S+VD++ D ET F CD WL+
Sbjct: 825 DTFNFPDMLSLGHLC-KLRVWHDNKGIFPGWHLSYVDVK----DNSRDETFHFQCDCWLS 879
Query: 1419 TSEDDKKTIRELVPYDIFTEKYMKDGSLRQVYKEVEEPLDIVLYSVQIFTGNIPGAGTDA 1478
SE D +T+R+ + ++ E+EE Y + I TGN G T
Sbjct: 880 KSEGDGQTVRDFACAN------------NKICDELEE----TTYEIVIETGN--GGETRE 921
Query: 1479 KVYITIYGDLGDTGERYLGKSENRTNKFERGTADTFIIEAADLGVIYKIKLRH----DN- 1533
V++ + G + E +L ++ +R F +GT DTF ++ LG I + + H D
Sbjct: 922 NVWLILEGRKNRSKE-FLMENSSRQRAFRKGTTDTFEFDSIYLGDIASLCVGHLAREDRF 980
Query: 1534 -SKWCADWYVEKVEIWNDTNEDEFLFLCGRWLSLKKEDGRLERLFYEKEYTGDRSSNCSS 1592
K W+V+ + I + + F C + LK+ +R +++
Sbjct: 981 IPKRELAWHVKTITITEMEYGNVYFFNCDCLIPLKR-----KRKYFKV------------ 1023
Query: 1593 PADFWEIALSSKMADVDISTVTGPMADYVQEGPIIPYYVSVTTGKHKDAATDSRAFIFLI 1652
+++ T A VQ + Y V VTTG A TD+ F+ +
Sbjct: 1024 ---------------FEVTKTTESFASKVQSLVPVKYEVIVTTGYEPGAGTDANVFVTIF 1068
Query: 1653 GEDDERSKRIWLDYPRGKRGFSRGSVEEFYVAGLDVGIIK 1692
G + + KR R F RGS + F++ L++ + +
Sbjct: 1069 GANGDTGKRELKQKMRNL--FERGSTDRFFLETLELVVTR 1106
Score = 378 bits (971), Expect = e-104
Identities = 290/951 (30%), Positives = 451/951 (47%), Gaps = 104/951 (10%)
Query: 41 KARVYEVVTATGDVRGAGTDANVFITLFG-ENGLSPKLQLTSKSKS-AFEKGNVDVFRVR 98
K+ + V TG + AGTDANVFITLFG ++ L +SK+ S FE+ ++++F V
Sbjct: 62 KSTTFSVTIKTGVKKNAGTDANVFITLFGTQDDTGMTLLKSSKTNSDKFERDSIEIFTVE 121
Query: 99 TNNVGLIYKVRIEHDNTGLNASWYLDHVIVTDMKRPHLRYYFNCNNWLSKVEGDRQWCRD 158
T ++G ++KVR+ HDNTG W++D V V D F C WL+K E D RD
Sbjct: 122 TLDLGDLWKVRLGHDNTGKAPGWFVDWVEV-DAPSLGKCMTFPCGRWLAKNEDDGSIIRD 180
Query: 159 LL-ASFNPMDMPRGNKYEVKVYTGDVIGAGTDADVFINIFG--------EYGDTGERRLE 209
L A YE+ +YT DV AGTDA++FI I+G +Y T +R
Sbjct: 181 LFHAELQTRLYTPFVPYEITLYTSDVFAAGTDANIFIIIYGCDAVCTQQKYLCTNKR--- 237
Query: 210 NEKDNFEKGAEDRFILDAPDLGQLM-KINVGHNNKGGSAGWFLSQI----VIEDIGNKRK 264
+K FE+ + RFI++ D+G+++ KI +GHNN G + GW S + ++ D
Sbjct: 238 EQKQFFERKSASRFIVELEDVGEIIEKIRIGHNNTGMNPGWHCSHVDIRRLLPDKDGAET 297
Query: 265 YDFPLNRWLALDEDDGKIQRDILVGGAET--------------------TAITYIVTVFT 304
FP +RWLA EDD K R+++ T + Y V +FT
Sbjct: 298 LTFPCDRWLATSEDDKKTIRELVPYDIFTEKYMKDGSLRQVYKEVEEPLDIVLYSVQIFT 357
Query: 305 GDVRGAGTKSKIYLVMYGARGNKNS---GKIFLEGGVFDRGRTDIFHIELAVLLSPLSRV 361
G++ GAGT +K+Y+ +YG G+ GK F+RG D F IE A L + ++
Sbjct: 358 GNIPGAGTDAKVYITIYGDLGDTGERYLGKSENRTNKFERGTADTFIIE-AADLGVIYKI 416
Query: 362 SVGHGNVGVNRGWFCEKVVILCPFTGIQQTFPCSNWLDEKKADGLIERQLYEM------- 414
+ H N W+ EKV I + F C WL KK DG +ER YE
Sbjct: 417 KLRHDNSKWCADWYVEKVEIWNDTNEDEFLFLCGRWLSLKKEDGRLERLFYEKEYTGDRS 476
Query: 415 -----------VSLRKKRLKK------------------FPWSLWVWTTDLKKAGTNSPI 445
++L K P+ + V T K A T+S
Sbjct: 477 SNCSSPADFWEIALSSKMADVDISTVTGPMADYVQEGPIIPYYVSVTTGKHKDAATDSRA 536
Query: 446 FIQIYGQKG-RTDEILLN-PNNK-WFKPGIIEKFRIELPDLGRFYKIRVWHDKRSSGSGW 502
FI + G+ R+ I L+ P K F G +E+F + D+G KI + HD S S W
Sbjct: 537 FIFLIGEDDERSKRIWLDYPRGKRGFSRGSVEEFYVAGLDVGIIKKIELGHDGASPESCW 596
Query: 503 HLERMTLMNTLNKDKYNFNCNRWLDANEDDNEIVREMTAEGPTVRRIMGMARYHVTVCTG 562
+E + L KY NCN WL + D R V I Y +TV TG
Sbjct: 597 LVEELCLAVPTQGTKYMLNCNCWLAKDRGDGITSRVFDLLDAMVVNIGVKVLYEMTVWTG 656
Query: 563 ELEGAGTDANVYLCLFGDVGDTGERLLYNCRNNTDLFEKGNADEFTIESVTMRNVRRVRI 622
++ G GTD+N+++ L+G G T E L + FE+ D F +E + + ++RI
Sbjct: 657 DVVGGGTDSNIFMTLYGINGSTEEMQLDKKKAR---FEREQNDTFIMEILDIAPFTKMRI 713
Query: 623 RHDGKGSGSGWYLDRVLVREEGQPESDNVEFPCLRWLDKDKDDGQLVRELLP-SDSSATL 681
R DG GS W+L+R+L++ D F WL + K LV E+ D +
Sbjct: 714 RIDGLGSRPEWFLERILLK--NMNTGDLTMFYYGDWLSQRKGKKTLVCEMCAVIDEEEMM 771
Query: 682 KNFRYHISLKTGDVSGASTDSRVYIKLYGDKSDTIKQVLLVSDNNLKDYFERGRVDEFTL 741
+ Y +++KT D+ GA TD+ V+I ++G+ D+ L S N K FER D F
Sbjct: 772 EWTSYTVAVKTSDILGAGTDANVFIIIFGENGDSGTLALKQSANWNK--FERNNTDTFNF 829
Query: 742 -ETLNIGNINRLVIGHDSTGMHASWFLGSVQIRVPRQGKQYTFPANRWLDKNQADGRL-- 798
+ L++G++ +L + HD+ G+ W L V ++ + + + F + WL K++ DG+
Sbjct: 830 PDMLSLGHLCKLRVWHDNKGIFPGWHLSYVDVKDNSRDETFHFQCDCWLSKSEGDGQTVR 889
Query: 799 EVELYPSEVVEIQKLVHYEVEIWTGDVGGAGTSARVYMQIYGEKGKTEVLFL--SSRSKV 856
+ +++ + + YE+ I TG+ G T V++ + G K +++ + SSR +
Sbjct: 890 DFACANNKICDELEETTYEIVIETGN--GGETRENVWLILEGRKNRSKEFLMENSSRQRA 947
Query: 857 FERASKDTFQLEAADVGEVYKLRLGHTG--EGFGP----SWFVDTVWLRHL 901
F + + DTF+ ++ +G++ L +GH + F P +W V T+ + +
Sbjct: 948 FRKGTTDTFEFDSIYLGDIASLCVGHLAREDRFIPKRELAWHVKTITITEM 998
Score = 366 bits (939), Expect = e-100
Identities = 277/958 (28%), Positives = 458/958 (47%), Gaps = 113/958 (11%)
Query: 27 ASEDDEGELEHEYYKARV----------YEVVTATGDVRGAGTDANVFITLFGENGL--S 74
A +D+G + + + A + YE+ T DV AGTDAN+FI ++G + +
Sbjct: 169 AKNEDDGSIIRDLFHAELQTRLYTPFVPYEITLYTSDVFAAGTDANIFIIIYGCDAVCTQ 228
Query: 75 PKLQLTSK--SKSAFEKGNVDVFRVRTNNVG-LIYKVRIEHDNTGLNASWYLDHVIVTDM 131
K T+K K FE+ + F V +VG +I K+RI H+NTG+N W+ HV + +
Sbjct: 229 QKYLCTNKREQKQFFERKSASRFIVELEDVGEIIEKIRIGHNNTGMNPGWHCSHVDIRRL 288
Query: 132 ---KRPHLRYYFNCNNWLSKVEGDRQWCRDLLAS--FNPMDMPRGNK------------- 173
K F C+ WL+ E D++ R+L+ F M G+
Sbjct: 289 LPDKDGAETLTFPCDRWLATSEDDKKTIRELVPYDIFTEKYMKDGSLRQVYKEVEEPLDI 348
Query: 174 --YEVKVYTGDVIGAGTDADVFINIFGEYGDTGERRL---ENEKDNFEKGAEDRFILDAP 228
Y V+++TG++ GAGTDA V+I I+G+ GDTGER L EN + FE+G D FI++A
Sbjct: 349 VLYSVQIFTGNIPGAGTDAKVYITIYGDLGDTGERYLGKSENRTNKFERGTADTFIIEAA 408
Query: 229 DLGQLMKINVGHNNKGGSAGWFLSQIVIEDIGNKRKYDFPLNRWLALDEDDGKIQR---- 284
DLG + KI + H+N A W++ ++ I + N+ ++ F RWL+L ++DG+++R
Sbjct: 409 DLGVIYKIKLRHDNSKWCADWYVEKVEIWNDTNEDEFLFLCGRWLSLKKEDGRLERLFYE 468
Query: 285 ---------------------------DILVGGA---------ETTAITYIVTVFTGDVR 308
D+ + E I Y V+V TG +
Sbjct: 469 KEYTGDRSSNCSSPADFWEIALSSKMADVDISTVTGPMADYVQEGPIIPYYVSVTTGKHK 528
Query: 309 GAGTKSKIYLVMYGARGNKNSGKIFLE----GGVFDRGRTDIFHIELAVLLSPLSRVSVG 364
A T S+ ++ + G ++ S +I+L+ F RG + F++ + + + ++ +G
Sbjct: 529 DAATDSRAFIFLIG-EDDERSKRIWLDYPRGKRGFSRGSVEEFYVA-GLDVGIIKKIELG 586
Query: 365 HGNVGVNRGWFCEKVVILCPFTGIQQTFPCSNWLDEKKADGLIERQLYEMVSLRKKRLKK 424
H W E++ + P G + C+ WL + + DG+ R + ++ K
Sbjct: 587 HDGASPESCWLVEELCLAVPTQGTKYMLNCNCWLAKDRGDGITSRVFDLLDAMVVNIGVK 646
Query: 425 FPWSLWVWTTDLKKAGTNSPIFIQIYGQKGRTDEILLNPNNKWFKPGIIEKFRIELPDLG 484
+ + VWT D+ GT+S IF+ +YG G T+E+ L+ F+ + F +E+ D+
Sbjct: 647 VLYEMTVWTGDVVGGGTDSNIFMTLYGINGSTEEMQLDKKKARFEREQNDTFIMEILDIA 706
Query: 485 RFYKIRVWHDKRSSGSGWHLERMTLMNTLNKDKYNFNCNRWLDANEDDNEIVREMTAEGP 544
F K+R+ D S W LER+ L N D F WL + +V EM A
Sbjct: 707 PFTKMRIRIDGLGSRPEWFLERILLKNMNTGDLTMFYYGDWLSQRKGKKTLVCEMCAVID 766
Query: 545 TVRRIMGMARYHVTVCTGELEGAGTDANVYLCLFGDVGDTGERLLYNCRNNTDLFEKGNA 604
+M Y V V T ++ GAGTDANV++ +FG+ GD+G L N + FE+ N
Sbjct: 767 E-EEMMEWTSYTVAVKTSDILGAGTDANVFIIIFGENGDSGTLALKQSAN-WNKFERNNT 824
Query: 605 DEFTI-ESVTMRNVRRVRIRHDGKGSGSGWYLDRVLVREEGQPESDNVEFPCLRWLDKDK 663
D F + +++ ++ ++R+ HD KG GW+L V V++ + E+ F C WL K +
Sbjct: 825 DTFNFPDMLSLGHLCKLRVWHDNKGIFPGWHLSYVDVKDNSRDET--FHFQCDCWLSKSE 882
Query: 664 DDGQLVRELLPSDSSAT--LKNFRYHISLKTGDVSGASTDSRVYIKLYGDKSDTIKQVLL 721
DGQ VR+ +++ L+ Y I ++TG+ G T V++ L G K+ + + L
Sbjct: 883 GDGQTVRDFACANNKICDELEETTYEIVIETGN--GGETRENVWLILEGRKNRS--KEFL 938
Query: 722 VSDNNLKDYFERGRVDEFTLETLNIGNINRLVIGHDSTG------MHASWFLGSVQIRVP 775
+ +++ + F +G D F +++ +G+I L +GH + +W + ++ I
Sbjct: 939 MENSSRQRAFRKGTTDTFEFDSIYLGDIASLCVGHLAREDRFIPKRELAWHVKTITITEM 998
Query: 776 RQGKQYTFPANRWLDKNQADGRLEV-------ELYPSEVVEIQKLVHYEVEIWTGDVGGA 828
G Y F + + + +V E + S+V + V YEV + TG GA
Sbjct: 999 EYGNVYFFNCDCLIPLKRKRKYFKVFEVTKTTESFASKVQSLVP-VKYEVIVTTGYEPGA 1057
Query: 829 GTSARVYMQIYGEKGKTEVLFLSSRSK-VFERASKDTFQLEAADVGEVYKLRLGHTGE 885
GT A V++ I+G G T L + + +FER S D F LE E+ RLG E
Sbjct: 1058 GTDANVFVTIFGANGDTGKRELKQKMRNLFERGSTDRFFLETL---ELVVTRLGLAAE 1112
Score = 347 bits (891), Expect = 6e-95
Identities = 224/740 (30%), Positives = 359/740 (48%), Gaps = 103/740 (13%)
Query: 259 IGNKRKYDFPLNRWLALDEDDGKIQRDILV--------------GGAETTAI-------- 296
+ N+ Y FP RWLA++EDDG++ R++L GG + +
Sbjct: 1 MNNEITYYFPCQRWLAVEEDDGQLSRELLPVDESYVLPQSEEGRGGGDNNPLDNLALEQK 60
Query: 297 ----TYIVTVFTGDVRGAGTKSKIYLVMYGARGNKNSGKIFLEGGV-----FDRGRTDIF 347
T+ VT+ TG + AGT + +++ ++G + + +G L+ F+R +IF
Sbjct: 61 DKSTTFSVTIKTGVKKNAGTDANVFITLFGTQDD--TGMTLLKSSKTNSDKFERDSIEIF 118
Query: 348 HIELAVLLSPLSRVSVGHGNVGVNRGWFCEKVVILCPFTGIQQTFPCSNWLDEKKADGLI 407
+E + L L +V +GH N G GWF + V + P G TFPC WL + + DG I
Sbjct: 119 TVE-TLDLGDLWKVRLGHDNTGKAPGWFVDWVEVDAPSLGKCMTFPCGRWLAKNEDDGSI 177
Query: 408 ERQLYEMVSLRKKRLKKFPWSLWVWTTDLKKAGTNSPIFIQIYGQKGR-TDEILLNPNNK 466
R L+ + P+ + ++T+D+ AGT++ IFI IYG T + L N +
Sbjct: 178 IRDLFHAELQTRLYTPFVPYEITLYTSDVFAAGTDANIFIIIYGCDAVCTQQKYLCTNKR 237
Query: 467 ----WFKPGIIEKFRIELPDLGRFY-KIRVWHDKRSSGSGWHLERMTLMNTL----NKDK 517
+F+ +F +EL D+G KIR+ H+ GWH + + L +
Sbjct: 238 EQKQFFERKSASRFIVELEDVGEIIEKIRIGHNNTGMNPGWHCSHVDIRRLLPDKDGAET 297
Query: 518 YNFNCNRWLDANEDDNEIVREMTA---------EGPTVRRI-------MGMARYHVTVCT 561
F C+RWL +EDD + +RE+ + ++R++ + + Y V + T
Sbjct: 298 LTFPCDRWLATSEDDKKTIRELVPYDIFTEKYMKDGSLRQVYKEVEEPLDIVLYSVQIFT 357
Query: 562 GELEGAGTDANVYLCLFGDVGDTGERLLYNCRNNTDLFEKGNADEFTIESVTMRNVRRVR 621
G + GAGTDA VY+ ++GD+GDTGER L N T+ FE+G AD F IE+ + + +++
Sbjct: 358 GNIPGAGTDAKVYITIYGDLGDTGERYLGKSENRTNKFERGTADTFIIEAADLGVIYKIK 417
Query: 622 IRHDGKGSGSGWYLDRVLVREEGQPESDNVEFPCLRWLDKDKDDGQLVR----------- 670
+RHD + WY+++V + + D F C RWL K+DG+L R
Sbjct: 418 LRHDNSKWCADWYVEKVEIWND--TNEDEFLFLCGRWLSLKKEDGRLERLFYEKEYTGDR 475
Query: 671 -----------ELLPSDSSATL----------------KNFRYHISLKTGDVSGASTDSR 703
E+ S A + Y++S+ TG A+TDSR
Sbjct: 476 SSNCSSPADFWEIALSSKMADVDISTVTGPMADYVQEGPIIPYYVSVTTGKHKDAATDSR 535
Query: 704 VYIKLYGDKSDTIKQVLLVSDNNLKDYFERGRVDEFTLETLNIGNINRLVIGHDSTGMHA 763
+I L G+ + K++ L K F RG V+EF + L++G I ++ +GHD +
Sbjct: 536 AFIFLIGEDDERSKRIWLDYPRG-KRGFSRGSVEEFYVAGLDVGIIKKIELGHDGASPES 594
Query: 764 SWFLGSVQIRVPRQGKQYTFPANRWLDKNQADGRLE--VELYPSEVVEIQKLVHYEVEIW 821
W + + + VP QG +Y N WL K++ DG +L + VV I V YE+ +W
Sbjct: 595 CWLVEELCLAVPTQGTKYMLNCNCWLAKDRGDGITSRVFDLLDAMVVNIGVKVLYEMTVW 654
Query: 822 TGDVGGAGTSARVYMQIYGEKGKTEVLFLSSRSKVFERASKDTFQLEAADVGEVYKLRLG 881
TGDV G GT + ++M +YG G TE + L + FER DTF +E D+ K+R+
Sbjct: 655 TGDVVGGGTDSNIFMTLYGINGSTEEMQLDKKKARFEREQNDTFIMEILDIAPFTKMRIR 714
Query: 882 HTGEGFGPSWFVDTVWLRHL 901
G G P WF++ + L+++
Sbjct: 715 IDGLGSRPEWFLERILLKNM 734
Score = 347 bits (891), Expect = 6e-95
Identities = 255/871 (29%), Positives = 401/871 (46%), Gaps = 126/871 (14%)
Query: 136 LRYYFNCNNWLSKVEGDRQWCRDLL-----------------ASFNPMD------MPRGN 172
+ YYF C WL+ E D Q R+LL NP+D +
Sbjct: 5 ITYYFPCQRWLAVEEDDGQLSRELLPVDESYVLPQSEEGRGGGDNNPLDNLALEQKDKST 64
Query: 173 KYEVKVYTGDVIGAGTDADVFINIFGEYGDTGERRLENEK---DNFEKGAEDRFILDAPD 229
+ V + TG AGTDA+VFI +FG DTG L++ K D FE+ + + F ++ D
Sbjct: 65 TFSVTIKTGVKKNAGTDANVFITLFGTQDDTGMTLLKSSKTNSDKFERDSIEIFTVETLD 124
Query: 230 LGQLMKINVGHNNKGGSAGWFLSQIVIEDIGNKRKYDFPLNRWLALDEDDGKIQRDILVG 289
LG L K+ +GH+N G + GWF+ + ++ + FP RWLA +EDDG I RD+
Sbjct: 125 LGDLWKVRLGHDNTGKAPGWFVDWVEVDAPSLGKCMTFPCGRWLAKNEDDGSIIRDLFHA 184
Query: 290 GAETTAIT----YIVTVFTGDVRGAGTKSKIYLVMYGARG----------NKNSGKIFLE 335
+T T Y +T++T DV AGT + I++++YG NK K F
Sbjct: 185 ELQTRLYTPFVPYEITLYTSDVFAAGTDANIFIIIYGCDAVCTQQKYLCTNKREQKQF-- 242
Query: 336 GGVFDRGRTDIFHIELAVLLSPLSRVSVGHGNVGVNRGWFCEKVVI---LCPFTGIQQ-T 391
F+R F +EL + + ++ +GH N G+N GW C V I L G + T
Sbjct: 243 ---FERKSASRFIVELEDVGEIIEKIRIGHNNTGMNPGWHCSHVDIRRLLPDKDGAETLT 299
Query: 392 FPCSNWL----DEKKA----------------DGLIERQLYEMVSLRKKRLKKFPWSLWV 431
FPC WL D+KK DG + RQ+Y+ V ++ L +S+ +
Sbjct: 300 FPCDRWLATSEDDKKTIRELVPYDIFTEKYMKDGSL-RQVYKEV---EEPLDIVLYSVQI 355
Query: 432 WTTDLKKAGTNSPIFIQIYGQKGRTDEILL----NPNNKWFKPGIIEKFRIELPDLGRFY 487
+T ++ AGT++ ++I IYG G T E L N NK F+ G + F IE DLG Y
Sbjct: 356 FTGNIPGAGTDAKVYITIYGDLGDTGERYLGKSENRTNK-FERGTADTFIIEAADLGVIY 414
Query: 488 KIRVWHDKRSSGSGWHLERMTLMNTLNKDKYNFNCNRWLDANEDDNEIVREM-------- 539
KI++ HD + W++E++ + N N+D++ F C RWL ++D + R
Sbjct: 415 KIKLRHDNSKWCADWYVEKVEIWNDTNEDEFLFLCGRWLSLKKEDGRLERLFYEKEYTGD 474
Query: 540 --------------------------TAEGPTVRRIMG--MARYHVTVCTGELEGAGTDA 571
T GP + + Y+V+V TG+ + A TD+
Sbjct: 475 RSSNCSSPADFWEIALSSKMADVDISTVTGPMADYVQEGPIIPYYVSVTTGKHKDAATDS 534
Query: 572 NVYLCLFGDVGDTGERLLYNCRNNTDLFEKGNADEFTIESVTMRNVRRVRIRHDGKGSGS 631
++ L G+ + +R+ + F +G+ +EF + + + ++++ + HDG S
Sbjct: 535 RAFIFLIGEDDERSKRIWLDYPRGKRGFSRGSVEEFYVAGLDVGIIKKIELGHDGASPES 594
Query: 632 GWYLDRVLVREEGQPESDNVEFPCLRWLDKDKDDG--QLVRELLPSDSSATLKNFRYHIS 689
W ++ + + Q + C WL KD+ DG V +LL + Y ++
Sbjct: 595 CWLVEELCLAVPTQGTKYMLNCNC--WLAKDRGDGITSRVFDLLDAMVVNIGVKVLYEMT 652
Query: 690 LKTGDVSGASTDSRVYIKLYGDKSDTIKQVLLVSDNNLKDYFERGRVDEFTLETLNIGNI 749
+ TGDV G TDS +++ LYG T + L + K FER + D F +E L+I
Sbjct: 653 VWTGDVVGGGTDSNIFMTLYGINGSTEEMQL----DKKKARFEREQNDTFIMEILDIAPF 708
Query: 750 NRLVIGHDSTGMHASWFLGSVQIRVPRQGKQYTFPANRWLDKNQADGRLEVELYP-SEVV 808
++ I D G WFL + ++ G F WL + + L E+ +
Sbjct: 709 TKMRIRIDGLGSRPEWFLERILLKNMNTGDLTMFYYGDWLSQRKGKKTLVCEMCAVIDEE 768
Query: 809 EIQKLVHYEVEIWTGDVGGAGTSARVYMQIYGEKGKTEVLFL--SSRSKVFERASKDTFQ 866
E+ + Y V + T D+ GAGT A V++ I+GE G + L L S+ FER + DTF
Sbjct: 769 EMMEWTSYTVAVKTSDILGAGTDANVFIIIFGENGDSGTLALKQSANWNKFERNNTDTFN 828
Query: 867 L-EAADVGEVYKLRLGHTGEGFGPSWFVDTV 896
+ +G + KLR+ H +G P W + V
Sbjct: 829 FPDMLSLGHLCKLRVWHDNKGIFPGWHLSYV 859
Score = 300 bits (768), Expect = 1e-80
Identities = 226/746 (30%), Positives = 350/746 (46%), Gaps = 119/746 (15%)
Query: 992 FEAHRWLARGKEDNELVVELVPAG-------KPGPERNTYE------------VQVVTGN 1032
F RWLA ++D + + ELVP K G R Y+ VQ+ TGN
Sbjct: 300 FPCDRWLATSEDDKKTIRELVPYDIFTEKYMKDGSLRQVYKEVEEPLDIVLYSVQIFTGN 359
Query: 1033 VPKAGTDANVYLTIYGEEYGDTGERPLKKSD-KSNKFEQGQTDTFTIYAIDLGALTKIRI 1091
+P AGTDA VY+TIYG+ GDTGER L KS+ ++NKFE+G DTF I A DLG + KI++
Sbjct: 360 IPGAGTDAKVYITIYGD-LGDTGERYLGKSENRTNKFERGTADTFIIEAADLGVIYKIKL 418
Query: 1092 RHDNTGNRAGWFLDRIDITDMNNEITYYFPCQRWLAVEEDDGQLSRELLPVDESYVLPQS 1151
RHDN+ A W++++++I + NE + F C RWL+++++DG+L R L ++ Y
Sbjct: 419 RHDNSKWCADWYVEKVEIWNDTNEDEFLFLCGRWLSLKKEDGRLER--LFYEKEYT---- 472
Query: 1152 EEGRGGGDNNPLD--NLALEQK----DKSTT---------------FSVTIKTGVKKNAG 1190
R ++P D +AL K D ST + V++ TG K+A
Sbjct: 473 -GDRSSNCSSPADFWEIALSSKMADVDISTVTGPMADYVQEGPIIPYYVSVTTGKHKDAA 531
Query: 1191 TDANVFITLFGTQDDTGMTLLKSSKTNSDKFERDSIEIFTVETLDLGDLWKVRLGHDNTG 1250
TD+ FI L G D+ + F R S+E F V LD+G + K+ LGHD
Sbjct: 532 TDSRAFIFLIGEDDERSKRIWLDYPRGKRGFSRGSVEEFYVAGLDVGIIKKIELGHDGAS 591
Query: 1251 KAPGWFVDWVEVDAPSLGKCMTFPCGRWLAKNEDDGSIIRDLFHAELQTRLYTPFVPYEI 1310
W V+ + + P+ G C WLAK+ DG R + V YE+
Sbjct: 592 PESCWLVEELCLAVPTQGTKYMLNCNCWLAKDRGDGITSRVFDLLDAMVVNIGVKVLYEM 651
Query: 1311 TLYTSDVFAAGTDANIFIIIYGCDAVCTQQKYLCTNKREQKQFFERKSASRFIVELEDVG 1370
T++T DV GTD+NIF+ +YG + T++ L ++K FER+ FI+E+ D+
Sbjct: 652 TVWTGDVVGGGTDSNIFMTLYGING-STEEMQL----DKKKARFEREQNDTFIMEILDIA 706
Query: 1371 EIIEKIRIGHNNTGMNPGWHCSHVDIRRLLPDKDGAETLTFPCDRWLATSEDDKKTIREL 1430
K+RI + G P W + LL + + + F WL+ + K + E+
Sbjct: 707 P-FTKMRIRIDGLGSRPEWFLERI----LLKNMNTGDLTMFYYGDWLSQRKGKKTLVCEM 761
Query: 1431 VPYDIFTEKYMKDGSLRQVYKEVEEPLDIVLYSVQIFTGNIPGAGTDAKVYITIYGDLGD 1490
+ EE ++ Y+V + T +I GAGTDA V+I I+G+ GD
Sbjct: 762 C-----------------AVIDEEEMMEWTSYTVAVKTSDILGAGTDANVFIIIFGENGD 804
Query: 1491 TGERYLGKSENRTNKFERGTADTF-IIEAADLGVIYKIKLRHDNSKWCADWYVEKVEIWN 1549
+G L +S N NKFER DTF + LG + K+++ HDN W++ V++ +
Sbjct: 805 SGTLALKQSAN-WNKFERNNTDTFNFPDMLSLGHLCKLRVWHDNKGIFPGWHLSYVDVKD 863
Query: 1550 DTNEDEFLFLCGRWLSLKKEDGRLERLFYEKEYTGDRSSNCSSPADFWEIALSSKMADVD 1609
++ ++ F F C WLS + DG+ R D
Sbjct: 864 NSRDETFHFQCDCWLSKSEGDGQTVR---------------------------------D 890
Query: 1610 ISTVTGPMADYVQEGPIIPYYVSVTTGKHKDAATDSRAFIFLIGED-DERSKRIWLDYPR 1668
+ + D ++E Y + + TG ++R ++LI E RSK ++
Sbjct: 891 FACANNKICDELEE---TTYEIVIETGN----GGETRENVWLILEGRKNRSKEFLMENSS 943
Query: 1669 GKRGFSRGSVEEFYVAGLDVGIIKKI 1694
+R F +G+ + F + +G I +
Sbjct: 944 RQRAFRKGTTDTFEFDSIYLGDIASL 969
Score = 211 bits (536), Expect = 8e-54
Identities = 174/605 (28%), Positives = 277/605 (45%), Gaps = 76/605 (12%)
Query: 1654 EDDERSKRIWLDYPRGKRGFSR-GSVEEFYVAGLDVGIIKKIE-----VLYEMTVWTGDV 1707
EDD+++ R + Y + + GS+ + Y K++E VLY + ++TG++
Sbjct: 310 EDDKKTIRELVPYDIFTEKYMKDGSLRQVY---------KEVEEPLDIVLYSVQIFTGNI 360
Query: 1708 VGGGTDSNIFMTLYGINGSTEEMQLDKKKAR---FEREQNDTFIMEILDIAPFTKMRIRI 1764
G GTD+ +++T+YG G T E L K + R FER DTFI+E D+ K+++R
Sbjct: 361 PGAGTDAKVYITIYGDLGDTGERYLGKSENRTNKFERGTADTFIIEAADLGVIYKIKLRH 420
Query: 1765 DGLGSRPEWFLERILLKNMNTGDLTMFYYGDWLSQRK---------------GKKTLVCE 1809
D +W++E++ + N D +F G WLS +K G ++ C
Sbjct: 421 DNSKWCADWYVEKVEIWNDTNEDEFLFLCGRWLSLKKEDGRLERLFYEKEYTGDRSSNCS 480
Query: 1810 MCA----------------------VIDEEEMMEWTSYTVAVKTSDILGAGTDANVFIII 1847
A + D + Y V+V T A TD+ FI +
Sbjct: 481 SPADFWEIALSSKMADVDISTVTGPMADYVQEGPIIPYYVSVTTGKHKDAATDSRAFIFL 540
Query: 1848 FGENGD-SGTLALKQSANWNKFERNNTDTFNFPDMLSLGHLCKLRVWHDNKGIFPGWHLS 1906
GE+ + S + L F R + + F + L +G + K+ + HD W +
Sbjct: 541 IGEDDERSKRIWLDYPRGKRGFSRGSVEEF-YVAGLDVGIIKKIELGHDGASPESCWLVE 599
Query: 1907 YVDVKDNSRDETFHFQCDCWLSKSEGDGQTVRDFACANNKICDELEETTYEIVIETGN-- 1964
+ + ++ + C+CWL+K GDG T R F + + + + YE+ + TG+
Sbjct: 600 ELCLAVPTQGTKYMLNCNCWLAKDRGDGITSRVFDLLDAMVVNIGVKVLYEMTVWTGDVV 659
Query: 1965 GGETRENVWLILEGRKNRSKEFLMENSSRQRAFRKGTTDTFEFDSIYLGDIASLCVGHLA 2024
GG T N+++ L G ++E M+ ++ F + DTF + + + + +
Sbjct: 660 GGGTDSNIFMTLYGINGSTEE--MQLDKKKARFEREQNDTFIMEILDIAPFTKMRI---- 713
Query: 2025 REDRFIPKRELAWHVKTITITEMEYGNV-YFFNCDCLIPLKRKRKYFKVFEVTKTTESFA 2083
R D + E W ++ I + M G++ F+ D L +RK K V E+ +
Sbjct: 714 RIDGLGSRPE--WFLERILLKNMNTGDLTMFYYGDWLS--QRKGKKTLVCEMCAVID--- 766
Query: 2084 SKVQSLVPVKYEVIVTTGYEPGAGTDANVFVTIFGANGDTGKRELKQKMR-NLFERGSTD 2142
+ + + Y V V T GAGTDANVF+ IFG NGD+G LKQ N FER +TD
Sbjct: 767 -EEEMMEWTSYTVAVKTSDILGAGTDANVFIIIFGENGDSGTLALKQSANWNKFERNNTD 825
Query: 2143 RF-FLETLELGELRKVRLEHDSSGYCSGWLVEKVEVTNTSTGVATIFNCGRWLDKKRGDG 2201
F F + L LG L K+R+ HD+ G GW + V+V + S F C WL K GDG
Sbjct: 826 TFNFPDMLSLGHLCKLRVWHDNKGIFPGWHLSYVDVKDNSRDETFHFQCDCWLSKSEGDG 885
Query: 2202 LTWRD 2206
T RD
Sbjct: 886 QTVRD 890
Score = 197 bits (501), Expect = 1e-49
Identities = 136/410 (33%), Positives = 203/410 (49%), Gaps = 32/410 (7%)
Query: 1817 EEMMEWTSYTVAVKTSDILGAGTDANVFIIIFGENGDSGTLALKQS-ANWNKFERNNTDT 1875
E+ + T+++V +KT AGTDANVFI +FG D+G LK S N +KFER++ +
Sbjct: 58 EQKDKSTTFSVTIKTGVKKNAGTDANVFITLFGTQDDTGMTLLKSSKTNSDKFERDSIEI 117
Query: 1876 FNFPDMLSLGHLCKLRVWHDNKGIFPGWHLSYVDVKDNSRDETFHFQCDCWLSKSEGDGQ 1935
F + L LG L K+R+ HDN G PGW + +V+V S + F C WL+K+E DG
Sbjct: 118 FTV-ETLDLGDLWKVRLGHDNTGKAPGWFVDWVEVDAPSLGKCMTFPCGRWLAKNEDDGS 176
Query: 1936 TVRDFACANNKICDELEETTYEIVIETGN--GGETRENVWLILEGRKN--RSKEFLMENS 1991
+RD A + YEI + T + T N+++I+ G +++L N
Sbjct: 177 IIRDLFHAELQTRLYTPFVPYEITLYTSDVFAAGTDANIFIIIYGCDAVCTQQKYLCTNK 236
Query: 1992 SRQRAF-RKGTTDTFEFDSIYLGDIAS-LCVGHLAREDRFIPKRELAWHVKTITITEM-- 2047
Q+ F + + F + +G+I + +GH P WH + I +
Sbjct: 237 REQKQFFERKSASRFIVELEDVGEIIEKIRIGH--NNTGMNP----GWHCSHVDIRRLLP 290
Query: 2048 --EYGNVYFFNCDCLIPLKRKRKY-------FKVFEVTKTTESFASKVQSLVP-----VK 2093
+ F CD + K + +F + +V V V
Sbjct: 291 DKDGAETLTFPCDRWLATSEDDKKTIRELVPYDIFTEKYMKDGSLRQVYKEVEEPLDIVL 350
Query: 2094 YEVIVTTGYEPGAGTDANVFVTIFGANGDTGKREL--KQKMRNLFERGSTDRFFLETLEL 2151
Y V + TG PGAGTDA V++TI+G GDTG+R L + N FERG+ D F +E +L
Sbjct: 351 YSVQIFTGNIPGAGTDAKVYITIYGDLGDTGERYLGKSENRTNKFERGTADTFIIEAADL 410
Query: 2152 GELRKVRLEHDSSGYCSGWLVEKVEVTNTSTGVATIFNCGRWLDKKRGDG 2201
G + K++L HD+S +C+ W VEKVE+ N + +F CGRWL K+ DG
Sbjct: 411 GVIYKIKLRHDNSKWCADWYVEKVEIWNDTNEDEFLFLCGRWLSLKKEDG 460
Score = 149 bits (375), Expect = 4e-35
Identities = 143/601 (23%), Positives = 256/601 (42%), Gaps = 69/601 (11%)
Query: 1643 TDSRAFIFLIG------EDDERSKRIWLDYP-RGKRGFSRGSVEEFY-------VAGLDV 1688
T+ F+FL G ++D R +R++ + G R + S +F+ +A +D+
Sbjct: 440 TNEDEFLFLCGRWLSLKKEDGRLERLFYEKEYTGDRSSNCSSPADFWEIALSSKMADVDI 499
Query: 1689 GII---------KKIEVLYEMTVWTGDVVGGGTDSNIFMTLYGINGSTEE---MQLDKKK 1736
+ + + Y ++V TG TDS F+ L G + + + + K
Sbjct: 500 STVTGPMADYVQEGPIIPYYVSVTTGKHKDAATDSRAFIFLIGEDDERSKRIWLDYPRGK 559
Query: 1737 ARFEREQNDTFIMEILDIAPFTKMRIRIDGLGSRPEWFLERILLKNMNTGDLTMFYYGDW 1796
F R + F + LD+ K+ + DG W +E + L G M W
Sbjct: 560 RGFSRGSVEEFYVAGLDVGIIKKIELGHDGASPESCWLVEELCLAVPTQGTKYMLNCNCW 619
Query: 1797 LSQRKGKKTLVCEMCAVIDEEEMMEWTS--YTVAVKTSDILGAGTDANVFIIIFGENGDS 1854
L++ +G + + ++D + Y + V T D++G GTD+N+F+ ++G NG +
Sbjct: 620 LAKDRG-DGITSRVFDLLDAMVVNIGVKVLYEMTVWTGDVVGGGTDSNIFMTLYGINGST 678
Query: 1855 GTLALKQSANWNKFERNNTDTFNFPDMLSLGHLCKLRVWHDNKGIFPGWHLSYVDVKDNS 1914
+ L + +FER DTF ++L + K+R+ D G P W L + +K+ +
Sbjct: 679 EEMQLDKKK--ARFEREQNDTF-IMEILDIAPFTKMRIRIDGLGSRPEWFLERILLKNMN 735
Query: 1915 RDETFHFQCDCWLSKSEGDGQTVRDFACANNKICDE---LEETTYEIVIETGN--GGETR 1969
+ F WLS+ +G + C + DE +E T+Y + ++T + G T
Sbjct: 736 TGDLTMFYYGDWLSQRKGK----KTLVCEMCAVIDEEEMMEWTSYTVAVKTSDILGAGTD 791
Query: 1970 ENVWLILEGRKNRSKEFLMENSSRQRAFRKGTTDTFEF-DSIYLGDIASLCVGHLAREDR 2028
NV++I+ G S ++ S+ F + TDTF F D + LG + L V H
Sbjct: 792 ANVFIIIFGENGDSGTLALKQSANWNKFERNNTDTFNFPDMLSLGHLCKLRVWH--DNKG 849
Query: 2029 FIPKRELAWHVKTITITEMEYGNVYFFNCDCLIPLKRKRKYFKVFEVTKTTESFA---SK 2085
P WH+ + + + + F CDC + K +T FA +K
Sbjct: 850 IFP----GWHLSYVDVKDNSRDETFHFQCDCWLS--------KSEGDGQTVRDFACANNK 897
Query: 2086 V-QSLVPVKYEVIVTTGYEPGAGTDANVFVTIFGANGDTGKRELKQKMR-NLFERGSTDR 2143
+ L YE+++ TG G T NV++ + G + + ++ R F +G+TD
Sbjct: 898 ICDELEETTYEIVIETG--NGGETRENVWLILEGRKNRSKEFLMENSSRQRAFRKGTTDT 955
Query: 2144 FFLETLELGELRKVRLEHDS------SGYCSGWLVEKVEVTNTSTGVATIFNCGRWLDKK 2197
F +++ LG++ + + H + W V+ + +T G FNC + K
Sbjct: 956 FEFDSIYLGDIASLCVGHLAREDRFIPKRELAWHVKTITITEMEYGNVYFFNCDCLIPLK 1015
Query: 2198 R 2198
R
Sbjct: 1016 R 1016
Score = 111 bits (278), Expect = 7e-24
Identities = 59/117 (50%), Positives = 71/117 (60%), Gaps = 2/117 (1%)
Query: 2094 YEVIVTTGYEPGAGTDANVFVTIFGANGDTGKRELKQKMRNL--FERGSTDRFFLETLEL 2151
+ V + TG + AGTDANVF+T+FG DTG LK N FER S + F +ETL+L
Sbjct: 66 FSVTIKTGVKKNAGTDANVFITLFGTQDDTGMTLLKSSKTNSDKFERDSIEIFTVETLDL 125
Query: 2152 GELRKVRLEHDSSGYCSGWLVEKVEVTNTSTGVATIFNCGRWLDKKRGDGLTWRDLF 2208
G+L KVRL HD++G GW V+ VEV S G F CGRWL K DG RDLF
Sbjct: 126 GDLWKVRLGHDNTGKAPGWFVDWVEVDAPSLGKCMTFPCGRWLAKNEDDGSIIRDLF 182
Score = 95.1 bits (235), Expect = 7e-19
Identities = 91/336 (27%), Positives = 142/336 (42%), Gaps = 64/336 (19%)
Query: 1918 TFHFQCDCWLSKSEGDGQTVRDF----------------ACANNKICDEL------EETT 1955
T++F C WL+ E DGQ R+ +N D L + TT
Sbjct: 6 TYYFPCQRWLAVEEDDGQLSRELLPVDESYVLPQSEEGRGGGDNNPLDNLALEQKDKSTT 65
Query: 1956 YEIVIETG---NGGETRENVWLILEGRKNRSKEFLMENS-SRQRAFRKGTTDTFEFDSIY 2011
+ + I+TG N G T NV++ L G ++ + L+++S + F + + + F +++
Sbjct: 66 FSVTIKTGVKKNAG-TDANVFITLFGTQDDTGMTLLKSSKTNSDKFERDSIEIFTVETLD 124
Query: 2012 LGDIASLCVGHLAREDRFIPKRELAWHVKTITITEMEYGNVYFFNCDCLIPLKRK----- 2066
LGD+ + +GH D + W V + + G F C +
Sbjct: 125 LGDLWKVRLGH----DN--TGKAPGWFVDWVEVDAPSLGKCMTFPCGRWLAKNEDDGSII 178
Query: 2067 RKYFKVFEVTKTTESFASKVQSLVPVKYEVIVTTGYEPGAGTDANVFVTIFGANG----- 2121
R F T+ F V YE+ + T AGTDAN+F+ I+G +
Sbjct: 179 RDLFHAELQTRLYTPF---------VPYEITLYTSDVFAAGTDANIFIIIYGCDAVCTQQ 229
Query: 2122 ---DTGKRELKQKMRNLFERGSTDRFFLETLELGE-LRKVRLEHDSSGYCSGWLVEKVEV 2177
T KRE KQ FER S RF +E ++GE + K+R+ H+++G GW V++
Sbjct: 230 KYLCTNKREQKQ----FFERKSASRFIVELEDVGEIIEKIRIGHNNTGMNPGWHCSHVDI 285
Query: 2178 TN---TSTGVATI-FNCGRWLDKKRGDGLTWRDLFP 2209
G T+ F C RWL D T R+L P
Sbjct: 286 RRLLPDKDGAETLTFPCDRWLATSEDDKKTIRELVP 321
>gi|224458290 lipoxygenase homology domains 1 isoform 3 [Homo sapiens]
Length = 512
Score = 1060 bits (2741), Expect = 0.0
Identities = 512/512 (100%), Positives = 512/512 (100%)
Query: 1700 MTVWTGDVVGGGTDSNIFMTLYGINGSTEEMQLDKKKARFEREQNDTFIMEILDIAPFTK 1759
MTVWTGDVVGGGTDSNIFMTLYGINGSTEEMQLDKKKARFEREQNDTFIMEILDIAPFTK
Sbjct: 1 MTVWTGDVVGGGTDSNIFMTLYGINGSTEEMQLDKKKARFEREQNDTFIMEILDIAPFTK 60
Query: 1760 MRIRIDGLGSRPEWFLERILLKNMNTGDLTMFYYGDWLSQRKGKKTLVCEMCAVIDEEEM 1819
MRIRIDGLGSRPEWFLERILLKNMNTGDLTMFYYGDWLSQRKGKKTLVCEMCAVIDEEEM
Sbjct: 61 MRIRIDGLGSRPEWFLERILLKNMNTGDLTMFYYGDWLSQRKGKKTLVCEMCAVIDEEEM 120
Query: 1820 MEWTSYTVAVKTSDILGAGTDANVFIIIFGENGDSGTLALKQSANWNKFERNNTDTFNFP 1879
MEWTSYTVAVKTSDILGAGTDANVFIIIFGENGDSGTLALKQSANWNKFERNNTDTFNFP
Sbjct: 121 MEWTSYTVAVKTSDILGAGTDANVFIIIFGENGDSGTLALKQSANWNKFERNNTDTFNFP 180
Query: 1880 DMLSLGHLCKLRVWHDNKGIFPGWHLSYVDVKDNSRDETFHFQCDCWLSKSEGDGQTVRD 1939
DMLSLGHLCKLRVWHDNKGIFPGWHLSYVDVKDNSRDETFHFQCDCWLSKSEGDGQTVRD
Sbjct: 181 DMLSLGHLCKLRVWHDNKGIFPGWHLSYVDVKDNSRDETFHFQCDCWLSKSEGDGQTVRD 240
Query: 1940 FACANNKICDELEETTYEIVIETGNGGETRENVWLILEGRKNRSKEFLMENSSRQRAFRK 1999
FACANNKICDELEETTYEIVIETGNGGETRENVWLILEGRKNRSKEFLMENSSRQRAFRK
Sbjct: 241 FACANNKICDELEETTYEIVIETGNGGETRENVWLILEGRKNRSKEFLMENSSRQRAFRK 300
Query: 2000 GTTDTFEFDSIYLGDIASLCVGHLAREDRFIPKRELAWHVKTITITEMEYGNVYFFNCDC 2059
GTTDTFEFDSIYLGDIASLCVGHLAREDRFIPKRELAWHVKTITITEMEYGNVYFFNCDC
Sbjct: 301 GTTDTFEFDSIYLGDIASLCVGHLAREDRFIPKRELAWHVKTITITEMEYGNVYFFNCDC 360
Query: 2060 LIPLKRKRKYFKVFEVTKTTESFASKVQSLVPVKYEVIVTTGYEPGAGTDANVFVTIFGA 2119
LIPLKRKRKYFKVFEVTKTTESFASKVQSLVPVKYEVIVTTGYEPGAGTDANVFVTIFGA
Sbjct: 361 LIPLKRKRKYFKVFEVTKTTESFASKVQSLVPVKYEVIVTTGYEPGAGTDANVFVTIFGA 420
Query: 2120 NGDTGKRELKQKMRNLFERGSTDRFFLETLELGELRKVRLEHDSSGYCSGWLVEKVEVTN 2179
NGDTGKRELKQKMRNLFERGSTDRFFLETLELGELRKVRLEHDSSGYCSGWLVEKVEVTN
Sbjct: 421 NGDTGKRELKQKMRNLFERGSTDRFFLETLELGELRKVRLEHDSSGYCSGWLVEKVEVTN 480
Query: 2180 TSTGVATIFNCGRWLDKKRGDGLTWRDLFPSV 2211
TSTGVATIFNCGRWLDKKRGDGLTWRDLFPSV
Sbjct: 481 TSTGVATIFNCGRWLDKKRGDGLTWRDLFPSV 512
Score = 254 bits (649), Expect = 7e-67
Identities = 181/551 (32%), Positives = 268/551 (48%), Gaps = 58/551 (10%)
Query: 1028 VVTGNVPKAGTDANVYLTIYGEEYGDTGERPLKKSDKSNKFEQGQTDTFTIYAIDLGALT 1087
V TG+V GTD+N+++T+YG G T E L K K +FE+ Q DTF + +D+ T
Sbjct: 3 VWTGDVVGGGTDSNIFMTLYGIN-GSTEEMQLDK--KKARFEREQNDTFIMEILDIAPFT 59
Query: 1088 KIRIRHDNTGNRAGWFLDRIDITDMNNEITYYFPCQRWLAVEEDDGQLSRELLPVDESYV 1147
K+RIR D G+R WFL+RI + +MN F WL+ + L E+ V +
Sbjct: 60 KMRIRIDGLGSRPEWFLERILLKNMNTGDLTMFYYGDWLSQRKGKKTLVCEMCAVIDE-- 117
Query: 1148 LPQSEEGRGGGDNNPLDNLALEQKDKSTTFSVTIKTGVKKNAGTDANVFITLFGTQDDTG 1207
E+ + T+++V +KT AGTDANVFI +FG D+G
Sbjct: 118 ---------------------EEMMEWTSYTVAVKTSDILGAGTDANVFIIIFGENGDSG 156
Query: 1208 MTLLKSSKTNSDKFERDSIEIFTV-ETLDLGDLWKVRLGHDNTGKAPGWFVDWVEVDAPS 1266
LK S N +KFER++ + F + L LG L K+R+ HDN G PGW + +V+V S
Sbjct: 157 TLALKQS-ANWNKFERNNTDTFNFPDMLSLGHLCKLRVWHDNKGIFPGWHLSYVDVKDNS 215
Query: 1267 LGKCMTFPCGRWLAKNEDDGSIIRDLFHAELQTRLYTPFVPYEITLYTSDVFAAGTDANI 1326
+ F C WL+K+E DG +RD A + YEI + T + T N+
Sbjct: 216 RDETFHFQCDCWLSKSEGDGQTVRDFACANNKICDELEETTYEIVIETGN--GGETRENV 273
Query: 1327 FIIIYGCDAVCTQQKYLCTNKREQKQFFERKSASRFIVELEDVGEIIEKIRIGH--NNTG 1384
++I+ G +++L N Q+ F + + F + +G+I + +GH
Sbjct: 274 WLILEGRKN--RSKEFLMENSSRQRAF-RKGTTDTFEFDSIYLGDIAS-LCVGHLAREDR 329
Query: 1385 MNP----GWHCSHVDIRRLLPDKDGAETLTFPCDRWLATSEDDKKTIRELVPYDIFTEKY 1440
P WH + I + + F CD + K + +F
Sbjct: 330 FIPKRELAWHVKTITITEM----EYGNVYFFNCDCLIPLKRKRKY-------FKVFEVTK 378
Query: 1441 MKDGSLRQVYKEVEEPLDIVLYSVQIFTGNIPGAGTDAKVYITIYGDLGDTGERYLGKSE 1500
+ +V V V Y V + TG PGAGTDA V++TI+G GDTG+R L +
Sbjct: 379 TTESFASKVQSLVP-----VKYEVIVTTGYEPGAGTDANVFVTIFGANGDTGKREL--KQ 431
Query: 1501 NRTNKFERGTADTFIIEAADLGVIYKIKLRHDNSKWCADWYVEKVEIWNDTNEDEFLFLC 1560
N FERG+ D F +E +LG + K++L HD+S +C+ W VEKVE+ N + +F C
Sbjct: 432 KMRNLFERGSTDRFFLETLELGELRKVRLEHDSSGYCSGWLVEKVEVTNTSTGVATIFNC 491
Query: 1561 GRWLSLKKEDG 1571
GRWL K+ DG
Sbjct: 492 GRWLDKKRGDG 502
Score = 218 bits (555), Expect = 5e-56
Identities = 155/513 (30%), Positives = 246/513 (47%), Gaps = 33/513 (6%)
Query: 51 TGDVRGAGTDANVFITLFGENGLSPKLQLTSKSKSAFEKGNVDVFRVRTNNVGLIYKVRI 110
TGDV G GTD+N+F+TL+G NG + ++QL K K+ FE+ D F + ++ K+RI
Sbjct: 5 TGDVVGGGTDSNIFMTLYGINGSTEEMQL-DKKKARFEREQNDTFIMEILDIAPFTKMRI 63
Query: 111 EHDNTGLNASWYLDHVIVTDMKRPHLRYYFNCNNWLSKVEGDRQWCRDLLASFNPMDMPR 170
D G W+L+ +++ +M L ++ +WLS+ +G + ++ A + +M
Sbjct: 64 RIDGLGSRPEWFLERILLKNMNTGDLTMFYY-GDWLSQRKGKKTLVCEMCAVIDEEEMME 122
Query: 171 GNKYEVKVYTGDVIGAGTDADVFINIFGEYGDTGERRLENEK--DNFEKGAEDRF-ILDA 227
Y V V T D++GAGTDA+VFI IFGE GD+G L+ + FE+ D F D
Sbjct: 123 WTSYTVAVKTSDILGAGTDANVFIIIFGENGDSGTLALKQSANWNKFERNNTDTFNFPDM 182
Query: 228 PDLGQLMKINVGHNNKGGSAGWFLSQIVIEDIGNKRKYDFPLNRWLALDEDDGKIQRDIL 287
LG L K+ V H+NKG GW LS + ++D + F + WL+ E DG+ RD
Sbjct: 183 LSLGHLCKLRVWHDNKGIFPGWHLSYVDVKDNSRDETFHFQCDCWLSKSEGDGQTVRDFA 242
Query: 288 VGG----AETTAITYIVTVFTGDVRGAGTKSKIYLVMYGARGNKNSGKIFL-----EGGV 338
E TY + + TG+ G T+ ++L++ G KN K FL
Sbjct: 243 CANNKICDELEETTYEIVIETGN--GGETRENVWLIL---EGRKNRSKEFLMENSSRQRA 297
Query: 339 FDRGRTDIFHIELAVLLSPLSRVSVGHGNVGVNR-------GWFCEKVVILCPFTGIQQT 391
F +G TD F + ++ L ++ + VGH +R W + + I G
Sbjct: 298 FRKGTTDTFEFD-SIYLGDIASLCVGH-LAREDRFIPKRELAWHVKTITITEMEYGNVYF 355
Query: 392 FPCSNWLDEKKADGLIE----RQLYEMVSLRKKRLKKFPWSLWVWTTDLKKAGTNSPIFI 447
F C + K+ + + E + + + L + + V T AGT++ +F+
Sbjct: 356 FNCDCLIPLKRKRKYFKVFEVTKTTESFASKVQSLVPVKYEVIVTTGYEPGAGTDANVFV 415
Query: 448 QIYGQKGRTDEILLNPN-NKWFKPGIIEKFRIELPDLGRFYKIRVWHDKRSSGSGWHLER 506
I+G G T + L F+ G ++F +E +LG K+R+ HD SGW +E+
Sbjct: 416 TIFGANGDTGKRELKQKMRNLFERGSTDRFFLETLELGELRKVRLEHDSSGYCSGWLVEK 475
Query: 507 MTLMNTLNKDKYNFNCNRWLDANEDDNEIVREM 539
+ + NT FNC RWLD D R++
Sbjct: 476 VEVTNTSTGVATIFNCGRWLDKKRGDGLTWRDL 508
Score = 214 bits (545), Expect = 8e-55
Identities = 142/522 (27%), Positives = 252/522 (48%), Gaps = 27/522 (5%)
Query: 300 VTVFTGDVRGAGTKSKIYLVMYGARGNKNSGKIFLEGGVFDRGRTDIFHIELAVLLSPLS 359
+TV+TGDV G GT S I++ +YG G+ ++ + F+R + D F +E+ + ++P +
Sbjct: 1 MTVWTGDVVGGGTDSNIFMTLYGINGSTEEMQLDKKKARFEREQNDTFIMEI-LDIAPFT 59
Query: 360 RVSVGHGNVGVNRGWFCEKVVILCPFTGIQQTFPCSNWLDEKKADGLIERQLYEMVSLRK 419
++ + +G WF E++++ TG F +WL ++K + ++ ++ +
Sbjct: 60 KMRIRIDGLGSRPEWFLERILLKNMNTGDLTMFYYGDWLSQRKGKKTLVCEMCAVID-EE 118
Query: 420 KRLKKFPWSLWVWTTDLKKAGTNSPIFIQIYGQKGRTDEILLNPNNKWFKPGIIEKFRIE 479
+ ++ +++ V T+D+ AGT++ +FI I+G+ G + + L + W K
Sbjct: 119 EMMEWTSYTVAVKTSDILGAGTDANVFIIIFGENGDSGTLALKQSANWNKFERNNTDTFN 178
Query: 480 LPD---LGRFYKIRVWHDKRSSGSGWHLERMTLMNTLNKDKYNFNCNRWLDANEDDNEIV 536
PD LG K+RVWHD + GWHL + + + + ++F C+ WL +E D + V
Sbjct: 179 FPDMLSLGHLCKLRVWHDNKGIFPGWHLSYVDVKDNSRDETFHFQCDCWLSKSEGDGQTV 238
Query: 537 REMTAEGPTVRRIMGMARYHVTVCTGELEGAGTDANVYLCLFGDVGDTGERLLYNCRNNT 596
R+ + + Y + + TG G T NV+L L G + E L+ N
Sbjct: 239 RDFACANNKICDELEETTYEIVIETGN--GGETRENVWLILEGRKNRSKEFLMENSSRQR 296
Query: 597 DLFEKGNADEFTIESVTMRNVRRVRIRHDGKGSGS------GWYLDRVLVREEGQPESDN 650
F KG D F +S+ + ++ + + H + W++ + + E E N
Sbjct: 297 -AFRKGTTDTFEFDSIYLGDIASLCVGHLAREDRFIPKRELAWHVKTITITEM---EYGN 352
Query: 651 VEF---PCLRWLDKDKDDGQLVRELLPSDSSAT----LKNFRYHISLKTGDVSGASTDSR 703
V F CL L + + ++ ++S A+ L +Y + + TG GA TD+
Sbjct: 353 VYFFNCDCLIPLKRKRKYFKVFEVTKTTESFASKVQSLVPVKYEVIVTTGYEPGAGTDAN 412
Query: 704 VYIKLYGDKSDTIKQVLLVSDNNLKDYFERGRVDEFTLETLNIGNINRLVIGHDSTGMHA 763
V++ ++G DT K+ L NL FERG D F LETL +G + ++ + HDS+G +
Sbjct: 413 VFVTIFGANGDTGKRELKQKMRNL---FERGSTDRFFLETLELGELRKVRLEHDSSGYCS 469
Query: 764 SWFLGSVQIRVPRQGKQYTFPANRWLDKNQADGRLEVELYPS 805
W + V++ G F RWLDK + DG +L+PS
Sbjct: 470 GWLVEKVEVTNTSTGVATIFNCGRWLDKKRGDGLTWRDLFPS 511
Score = 211 bits (538), Expect = 5e-54
Identities = 145/518 (27%), Positives = 251/518 (48%), Gaps = 29/518 (5%)
Query: 178 VYTGDVIGAGTDADVFINIFGEYGDTGERRLENEKDNFEKGAEDRFILDAPDLGQLMKIN 237
V+TGDV+G GTD+++F+ ++G G T E +L+ +K FE+ D FI++ D+ K+
Sbjct: 3 VWTGDVVGGGTDSNIFMTLYGINGSTEEMQLDKKKARFEREQNDTFIMEILDIAPFTKMR 62
Query: 238 VGHNNKGGSAGWFLSQIVIEDIGNKRKYDFPLNRWLALDEDDGKIQRDILVGGAETTAI- 296
+ + G WFL +I+++++ F WL+ + + ++ E +
Sbjct: 63 IRIDGLGSRPEWFLERILLKNMNTGDLTMFYYGDWLSQRKGKKTLVCEMCAVIDEEEMME 122
Query: 297 --TYIVTVFTGDVRGAGTKSKIYLVMYGARGNKNSGKIFLEGGV----FDRGRTDIFHIE 350
+Y V V T D+ GAGT + ++++++G G +SG + L+ F+R TD F+
Sbjct: 123 WTSYTVAVKTSDILGAGTDANVFIIIFGENG--DSGTLALKQSANWNKFERNNTDTFNFP 180
Query: 351 LAVLLSPLSRVSVGHGNVGVNRGWFCEKVVILCPFTGIQQTFPCSNWLDEKKADGLIERQ 410
+ L L ++ V H N G+ GW V + F C WL + + DG R
Sbjct: 181 DMLSLGHLCKLRVWHDNKGIFPGWHLSYVDVKDNSRDETFHFQCDCWLSKSEGDGQTVRD 240
Query: 411 LYEMVSLRKKRLKKFPWSLWVWTTDLKKAGTNSPIFIQIYGQKGRTDEILLNPNNKW--F 468
+ L++ + + + T + T +++ + G+K R+ E L+ +++ F
Sbjct: 241 FACANNKICDELEETTYEIVIETGN--GGETRENVWLILEGRKNRSKEFLMENSSRQRAF 298
Query: 469 KPGIIEKFRIELPDLGRFYKIRVWHDKRSS------GSGWHLERMTLMNTLNKDKYNFNC 522
+ G + F + LG + V H R WH++ +T+ + Y FNC
Sbjct: 299 RKGTTDTFEFDSIYLGDIASLCVGHLAREDRFIPKRELAWHVKTITITEMEYGNVYFFNC 358
Query: 523 NRWLDANEDDN-----EIVREMTAEGPTVRRIMGMARYHVTVCTGELEGAGTDANVYLCL 577
+ + E+ + + V+ ++ + +Y V V TG GAGTDANV++ +
Sbjct: 359 DCLIPLKRKRKYFKVFEVTKTTESFASKVQSLVPV-KYEVIVTTGYEPGAGTDANVFVTI 417
Query: 578 FGDVGDTGERLLYNCRNNTDLFEKGNADEFTIESVTMRNVRRVRIRHDGKGSGSGWYLDR 637
FG GDTG+R L N LFE+G+ D F +E++ + +R+VR+ HD G SGW +++
Sbjct: 418 FGANGDTGKRELKQKMRN--LFERGSTDRFFLETLELGELRKVRLEHDSSGYCSGWLVEK 475
Query: 638 VLVREEGQPESDNVEFPCLRWLDKDKDDGQLVRELLPS 675
V V + F C RWLDK + DG R+L PS
Sbjct: 476 VEVTNTSTGVA--TIFNCGRWLDKKRGDGLTWRDLFPS 511
Score = 209 bits (533), Expect = 2e-53
Identities = 149/483 (30%), Positives = 241/483 (49%), Gaps = 26/483 (5%)
Query: 431 VWTTDLKKAGTNSPIFIQIYGQKGRTDEILLNPNNKWFKPGIIEKFRIELPDLGRFYKIR 490
VWT D+ GT+S IF+ +YG G T+E+ L+ F+ + F +E+ D+ F K+R
Sbjct: 3 VWTGDVVGGGTDSNIFMTLYGINGSTEEMQLDKKKARFEREQNDTFIMEILDIAPFTKMR 62
Query: 491 VWHDKRSSGSGWHLERMTLMNTLNKDKYNFNCNRWLDANEDDNEIVREMTAEGPTVRRIM 550
+ D S W LER+ L N D F WL + +V EM A +M
Sbjct: 63 IRIDGLGSRPEWFLERILLKNMNTGDLTMFYYGDWLSQRKGKKTLVCEMCAVIDE-EEMM 121
Query: 551 GMARYHVTVCTGELEGAGTDANVYLCLFGDVGDTGERLLYNCRNNTDLFEKGNADEFTI- 609
Y V V T ++ GAGTDANV++ +FG+ GD+G L N + FE+ N D F
Sbjct: 122 EWTSYTVAVKTSDILGAGTDANVFIIIFGENGDSGTLALKQSAN-WNKFERNNTDTFNFP 180
Query: 610 ESVTMRNVRRVRIRHDGKGSGSGWYLDRVLVREEGQPESDNVEFPCLRWLDKDKDDGQLV 669
+ +++ ++ ++R+ HD KG GW+L V V++ + E+ F C WL K + DGQ V
Sbjct: 181 DMLSLGHLCKLRVWHDNKGIFPGWHLSYVDVKDNSRDET--FHFQCDCWLSKSEGDGQTV 238
Query: 670 RELLPSDSSAT--LKNFRYHISLKTGDVSGASTDSRVYIKLYGDKSDTIKQVLLVSDNNL 727
R+ +++ L+ Y I ++TG+ G T V++ L G K+ + + L+ +++
Sbjct: 239 RDFACANNKICDELEETTYEIVIETGN--GGETRENVWLILEGRKNRS--KEFLMENSSR 294
Query: 728 KDYFERGRVDEFTLETLNIGNINRLVIGHDSTG------MHASWFLGSVQIRVPRQGKQY 781
+ F +G D F +++ +G+I L +GH + +W + ++ I G Y
Sbjct: 295 QRAFRKGTTDTFEFDSIYLGDIASLCVGHLAREDRFIPKRELAWHVKTITITEMEYGNVY 354
Query: 782 TFPANRWLDKNQADGRLEV-------ELYPSEVVEIQKLVHYEVEIWTGDVGGAGTSARV 834
F + + + +V E + S+V + V YEV + TG GAGT A V
Sbjct: 355 FFNCDCLIPLKRKRKYFKVFEVTKTTESFASKVQSLVP-VKYEVIVTTGYEPGAGTDANV 413
Query: 835 YMQIYGEKGKTEVLFLSSRSK-VFERASKDTFQLEAADVGEVYKLRLGHTGEGFGPSWFV 893
++ I+G G T L + + +FER S D F LE ++GE+ K+RL H G+ W V
Sbjct: 414 FVTIFGANGDTGKRELKQKMRNLFERGSTDRFFLETLELGELRKVRLEHDSSGYCSGWLV 473
Query: 894 DTV 896
+ V
Sbjct: 474 EKV 476
Score = 180 bits (457), Expect = 1e-44
Identities = 141/528 (26%), Positives = 241/528 (45%), Gaps = 72/528 (13%)
Query: 1179 VTIKTGVKKNAGTDANVFITLFGTQDDTGMTLLKSSKTNSDKFERDSIEIFTVETLDLGD 1238
+T+ TG GTD+N+F+TL+G T L K +FER+ + F +E LD+
Sbjct: 1 MTVWTGDVVGGGTDSNIFMTLYGINGSTEEMQLDKKKA---RFEREQNDTFIMEILDIAP 57
Query: 1239 LWKVRLGHDNTGKAPGWFVDWVEVDAPSLGKCMTFPCGRWLAKNEDDGSIIRDLFHAELQ 1298
K+R+ D G P WF++ + + + G F G WL++ + +++ ++ A +
Sbjct: 58 FTKMRIRIDGLGSRPEWFLERILLKNMNTGDLTMFYYGDWLSQRKGKKTLVCEMC-AVID 116
Query: 1299 TRLYTPFVPYEITLYTSDVFAAGTDANIFIIIYGCDAVCTQQKYLCTNKREQKQFFERKS 1358
+ Y + + TSD+ AGTDAN+FIII+G + L + FER +
Sbjct: 117 EEEMMEWTSYTVAVKTSDILGAGTDANVFIIIFGENG---DSGTLALKQSANWNKFERNN 173
Query: 1359 ASRF-IVELEDVGEIIEKIRIGHNNTGMNPGWHCSHVDIRRLLPDKDGAETLTFPCDRWL 1417
F ++ +G + K+R+ H+N G+ PGWH S+VD++ D ET F CD WL
Sbjct: 174 TDTFNFPDMLSLGHLC-KLRVWHDNKGIFPGWHLSYVDVK----DNSRDETFHFQCDCWL 228
Query: 1418 ATSEDDKKTIRELVPYDIFTEKYMKDGSLRQVYKEVEEPLDIVLYSVQIFTGNIPGAGTD 1477
+ SE D +T+R+ + ++ E+EE Y + I TGN G T
Sbjct: 229 SKSEGDGQTVRDFACAN------------NKICDELEE----TTYEIVIETGN--GGETR 270
Query: 1478 AKVYITIYGDLGDTGERYLGKSENRTNKFERGTADTFIIEAADLGVIYKIKLRH----DN 1533
V++ + G + E +L ++ +R F +GT DTF ++ LG I + + H D
Sbjct: 271 ENVWLILEGRKNRSKE-FLMENSSRQRAFRKGTTDTFEFDSIYLGDIASLCVGHLAREDR 329
Query: 1534 --SKWCADWYVEKVEIWNDTNEDEFLFLCGRWLSLKKEDGRLERLFYEKEYTGDRSSNCS 1591
K W+V+ + I + + F C + LK+ +R +++
Sbjct: 330 FIPKRELAWHVKTITITEMEYGNVYFFNCDCLIPLKR-----KRKYFKV----------- 373
Query: 1592 SPADFWEIALSSKMADVDISTVTGPMADYVQEGPIIPYYVSVTTGKHKDAATDSRAFIFL 1651
+++ T A VQ + Y V VTTG A TD+ F+ +
Sbjct: 374 ----------------FEVTKTTESFASKVQSLVPVKYEVIVTTGYEPGAGTDANVFVTI 417
Query: 1652 IGEDDERSKRIWLDYPRGKRGFSRGSVEEFYVAGLDVGIIKKIEVLYE 1699
G + + KR R F RGS + F++ L++G ++K+ + ++
Sbjct: 418 FGANGDTGKRELKQKMRNL--FERGSTDRFFLETLELGELRKVRLEHD 463
Score = 180 bits (456), Expect = 2e-44
Identities = 129/400 (32%), Positives = 192/400 (48%), Gaps = 24/400 (6%)
Query: 36 EHEYYKARVYEVVTATGDVRGAGTDANVFITLFGENGLSPKLQLTSKSK-SAFEKGNVDV 94
E E + Y V T D+ GAGTDANVFI +FGENG S L L + + FE+ N D
Sbjct: 117 EEEMMEWTSYTVAVKTSDILGAGTDANVFIIIFGENGDSGTLALKQSANWNKFERNNTDT 176
Query: 95 FRVRTN-NVGLIYKVRIEHDNTGLNASWYLDHVIVTDMKRPHLRYYFNCNNWLSKVEGDR 153
F ++G + K+R+ HDN G+ W+L +V V D R ++F C+ WLSK EGD
Sbjct: 177 FNFPDMLSLGHLCKLRVWHDNKGIFPGWHLSYVDVKDNSRDET-FHFQCDCWLSKSEGDG 235
Query: 154 QWCRDLLASFNPM-DMPRGNKYEVKVYTGDVIGAGTDADVFINIFGEYGDTGERRLENEK 212
Q RD + N + D YE+ + TG+ G T +V++ + G + E +EN
Sbjct: 236 QTVRDFACANNKICDELEETTYEIVIETGN--GGETRENVWLILEGRKNRSKEFLMENSS 293
Query: 213 DN--FEKGAEDRFILDAPDLGQLMKINVGHNNKGG------SAGWFLSQIVIEDIGNKRK 264
F KG D F D+ LG + + VGH + W + I I ++
Sbjct: 294 RQRAFRKGTTDTFEFDSIYLGDIASLCVGHLAREDRFIPKRELAWHVKTITITEMEYGNV 353
Query: 265 YDFPLNRWLALDEDDGKIQRDILVGGAETTA--------ITYIVTVFTGDVRGAGTKSKI 316
Y F + + L + + E+ A + Y V V TG GAGT + +
Sbjct: 354 YFFNCDCLIPLKRKRKYFKVFEVTKTTESFASKVQSLVPVKYEVIVTTGYEPGAGTDANV 413
Query: 317 YLVMYGARGNKNSGKIFLE-GGVFDRGRTDIFHIELAVLLSPLSRVSVGHGNVGVNRGWF 375
++ ++GA G+ ++ + +F+RG TD F +E + L L +V + H + G GW
Sbjct: 414 FVTIFGANGDTGKRELKQKMRNLFERGSTDRFFLE-TLELGELRKVRLEHDSSGYCSGWL 472
Query: 376 CEKVVILCPFTGIQQTFPCSNWLDEKKADGLIERQLYEMV 415
EKV + TG+ F C WLD+K+ DGL R L+ V
Sbjct: 473 VEKVEVTNTSTGVATIFNCGRWLDKKRGDGLTWRDLFPSV 512
Score = 172 bits (436), Expect = 3e-42
Identities = 139/457 (30%), Positives = 217/457 (47%), Gaps = 64/457 (14%)
Query: 997 WLARGKEDNELVVEL--VPAGKPGPERNTYEVQVVTGNVPKAGTDANVYLTIYGEEYGDT 1054
WL++ K LV E+ V + E +Y V V T ++ AGTDANV++ I+GE GD+
Sbjct: 97 WLSQRKGKKTLVCEMCAVIDEEEMMEWTSYTVAVKTSDILGAGTDANVFIIIFGEN-GDS 155
Query: 1055 GERPLKKSDKSNKFEQGQTDTFTI-YAIDLGALTKIRIRHDNTGNRAGWFLDRIDITDMN 1113
G LK+S NKFE+ TDTF + LG L K+R+ HDN G GW L +D+ D +
Sbjct: 156 GTLALKQSANWNKFERNNTDTFNFPDMLSLGHLCKLRVWHDNKGIFPGWHLSYVDVKDNS 215
Query: 1114 NEITYYFPCQRWLAVEEDDGQLSRELLPVDESYVLPQSEEGRGGGDNNPLDNLALEQKDK 1173
+ T++F C WL+ E DGQ R+ +N D L +
Sbjct: 216 RDETFHFQCDCWLSKSEGDGQTVRDF----------------ACANNKICDEL------E 253
Query: 1174 STTFSVTIKTGVKKNAG-TDANVFITLFGTQDDTGMTLLKSSKTNSDKFERDSIEIFTVE 1232
TT+ + I+TG N G T NV++ L G ++ + L+++S + F + + + F +
Sbjct: 254 ETTYEIVIETG---NGGETRENVWLILEGRKNRSKEFLMENS-SRQRAFRKGTTDTFEFD 309
Query: 1233 TLDLGDLWKVRLGH----DN--TGKAPGWFVDWVEVDAPSLGKCMTFPCGRWLAKNED-- 1284
++ LGD+ + +GH D + W V + + G F C +
Sbjct: 310 SIYLGDIASLCVGHLAREDRFIPKRELAWHVKTITITEMEYGNVYFFNCDCLIPLKRKRK 369
Query: 1285 -----DGSIIRDLFHAELQTRLYTPFVPYEITLYTSDVFAAGTDANIFIIIYGCDAVCTQ 1339
+ + + F +++Q+ + V YE+ + T AGTDAN+F+ I+G +
Sbjct: 370 YFKVFEVTKTTESFASKVQSLVP---VKYEVIVTTGYEPGAGTDANVFVTIFGANG---- 422
Query: 1340 QKYLCTNKREQKQ----FFERKSASRFIVELEDVGEIIEKIRIGHNNTGMNPGWHCSHVD 1395
T KRE KQ FER S RF +E ++GE + K+R+ H+++G GW V+
Sbjct: 423 ----DTGKRELKQKMRNLFERGSTDRFFLETLELGE-LRKVRLEHDSSGYCSGWLVEKVE 477
Query: 1396 IRRLLPDKDGAETLTFPCDRWLATSEDDKKTIRELVP 1432
+ G T+ F C RWL D T R+L P
Sbjct: 478 VTN---TSTGVATI-FNCGRWLDKKRGDGLTWRDLFP 510
Score = 127 bits (318), Expect = 2e-28
Identities = 101/391 (25%), Positives = 175/391 (44%), Gaps = 40/391 (10%)
Query: 1698 YEMTVWTGDVVGGGTDSNIFMTLYGINGSTEEMQLDKKK--ARFEREQNDTF-IMEILDI 1754
Y + V T D++G GTD+N+F+ ++G NG + + L + +FER DTF ++L +
Sbjct: 126 YTVAVKTSDILGAGTDANVFIIIFGENGDSGTLALKQSANWNKFERNNTDTFNFPDMLSL 185
Query: 1755 APFTKMRIRIDGLGSRPEWFLERILLKNMNTGDLTMFYYGDWLSQRKGK----KTLVCEM 1810
K+R+ D G P W L + +K+ + + F WLS+ +G + C
Sbjct: 186 GHLCKLRVWHDNKGIFPGWHLSYVDVKDNSRDETFHFQCDCWLSKSEGDGQTVRDFACAN 245
Query: 1811 CAVIDEEEMMEWTSYTVAVKTSDILGAGTDANVFIIIFGENGDSGTLALKQSANWNKFER 1870
+ DE +E T+Y + ++T + G T NV++I+ G S ++ S+ F +
Sbjct: 246 NKICDE---LEETTYEIVIETGN--GGETRENVWLILEGRKNRSKEFLMENSSRQRAFRK 300
Query: 1871 NNTDTFNFPDMLSLGHLCKLRVWH--DNKGIFP----GWHLSYVDVKDNSRDETFHFQCD 1924
TDTF F D + LG + L V H P WH+ + + + + F CD
Sbjct: 301 GTTDTFEF-DSIYLGDIASLCVGHLAREDRFIPKRELAWHVKTITITEMEYGNVYFFNCD 359
Query: 1925 CWLS--------KSEGDGQTVRDFACANNKICDELEETTYEIVIETG--NGGETRENVWL 1974
C + K +T FA +K+ L YE+++ TG G T NV++
Sbjct: 360 CLIPLKRKRKYFKVFEVTKTTESFA---SKV-QSLVPVKYEVIVTTGYEPGAGTDANVFV 415
Query: 1975 ILEGRKNRSKEFLMENSSRQRAFRKGTTDTFEFDSIYLGDIASLCVGHLAREDRFIPKRE 2034
+ G + + ++ R F +G+TD F +++ LG++ + + H +
Sbjct: 416 TIFGANGDTGKRELKQKMR-NLFERGSTDRFFLETLELGELRKVRLEHDS------SGYC 468
Query: 2035 LAWHVKTITITEMEYGNVYFFNCDCLIPLKR 2065
W V+ + +T G FNC + KR
Sbjct: 469 SGWLVEKVEVTNTSTGVATIFNCGRWLDKKR 499
Score = 84.7 bits (208), Expect = 9e-16
Identities = 41/110 (37%), Positives = 66/110 (60%), Gaps = 1/110 (0%)
Query: 1694 IEVLYEMTVWTGDVVGGGTDSNIFMTLYGINGSTEEMQLDKK-KARFEREQNDTFIMEIL 1752
+ V YE+ V TG G GTD+N+F+T++G NG T + +L +K + FER D F +E L
Sbjct: 391 VPVKYEVIVTTGYEPGAGTDANVFVTIFGANGDTGKRELKQKMRNLFERGSTDRFFLETL 450
Query: 1753 DIAPFTKMRIRIDGLGSRPEWFLERILLKNMNTGDLTMFYYGDWLSQRKG 1802
++ K+R+ D G W +E++ + N +TG T+F G WL +++G
Sbjct: 451 ELGELRKVRLEHDSSGYCSGWLVEKVEVTNTSTGVATIFNCGRWLDKKRG 500
Score = 72.0 bits (175), Expect = 6e-12
Identities = 31/82 (37%), Positives = 48/82 (58%)
Query: 820 IWTGDVGGAGTSARVYMQIYGEKGKTEVLFLSSRSKVFERASKDTFQLEAADVGEVYKLR 879
+WTGDV G GT + ++M +YG G TE + L + FER DTF +E D+ K+R
Sbjct: 3 VWTGDVVGGGTDSNIFMTLYGINGSTEEMQLDKKKARFEREQNDTFIMEILDIAPFTKMR 62
Query: 880 LGHTGEGFGPSWFVDTVWLRHL 901
+ G G P WF++ + L+++
Sbjct: 63 IRIDGLGSRPEWFLERILLKNM 84
>gi|239754889 PREDICTED: similar to hCG2036697 [Homo sapiens]
Length = 1029
Score = 127 bits (319), Expect = 1e-28
Identities = 75/160 (46%), Positives = 92/160 (57%), Gaps = 3/160 (1%)
Query: 988 EQHKFEAHRWLARGKEDNELVVE--LVPAGKPGPERNTYEVQVVTGNVPKAGTDANVYLT 1045
+Q RWLAR +ED E+ E L+ G+P YEV V TG + AGT ANVY++
Sbjct: 5 KQFYVPVQRWLARDQEDGEICREFPLLSKGQPVLPVTIYEVNVATGELWNAGTVANVYIS 64
Query: 1046 IYGEEYGDTGERPLKKSDKSNKFEQGQTDTFTIYAIDLGALTKIRIRHDNTGNRAGWFLD 1105
I+GE+ GDTG R L +S S F +GQTDTF + A+ LG L KI I HD G GWFLD
Sbjct: 65 IHGEK-GDTGSRQLFRSKSSFNFLRGQTDTFFLEAVHLGDLCKIVIGHDGLGPGNGWFLD 123
Query: 1106 RIDITDMNNEITYYFPCQRWLAVEEDDGQLSRELLPVDES 1145
+ I D Y F C RWL EDD ++ REL D S
Sbjct: 124 DVVIKDPTTNYEYAFFCHRWLDQGEDDCKIVRELYARDNS 163
Score = 115 bits (287), Expect = 6e-25
Identities = 67/169 (39%), Positives = 104/169 (61%), Gaps = 13/169 (7%)
Query: 524 RWLDANEDDNEIVRE--MTAEGPTVRRIMGMARYHVTVCTGELEGAGTDANVYLCLFGDV 581
RWL +++D EI RE + ++G V + + Y V V TGEL AGT ANVY+ + G+
Sbjct: 13 RWLARDQEDGEICREFPLLSKGQPV---LPVTIYEVNVATGELWNAGTVANVYISIHGEK 69
Query: 582 GDTGERLLYNCRNNTDLFEKGNADEFTIESVTMRNVRRVRIRHDGKGSGSGWYLDRVLVR 641
GDTG R L+ +++ + F +G D F +E+V + ++ ++ I HDG G G+GW+LD V+++
Sbjct: 70 GDTGSRQLFRSKSSFN-FLRGQTDTFFLEAVHLGDLCKIVIGHDGLGPGNGWFLDDVVIK 128
Query: 642 EEGQPESDNVE--FPCLRWLDKDKDDGQLVRELLPSDSSATLKNFRYHI 688
+ + N E F C RWLD+ +DD ++VREL D+S RYH+
Sbjct: 129 D----PTTNYEYAFFCHRWLDQGEDDCKIVRELYARDNS-IFSASRYHV 172
Score = 110 bits (275), Expect = 2e-23
Identities = 70/174 (40%), Positives = 98/174 (56%), Gaps = 7/174 (4%)
Query: 137 RYYFNCNNWLSKVEGDRQWCRD--LLASFNPMDMPRGNKYEVKVYTGDVIGAGTDADVFI 194
++Y WL++ + D + CR+ LL+ P+ +P YEV V TG++ AGT A+V+I
Sbjct: 6 QFYVPVQRWLARDQEDGEICREFPLLSKGQPV-LPV-TIYEVNVATGELWNAGTVANVYI 63
Query: 195 NIFGEYGDTGERRLENEKD--NFEKGAEDRFILDAPDLGQLMKINVGHNNKGGSAGWFLS 252
+I GE GDTG R+L K NF +G D F L+A LG L KI +GH+ G GWFL
Sbjct: 64 SIHGEKGDTGSRQLFRSKSSFNFLRGQTDTFFLEAVHLGDLCKIVIGHDGLGPGNGWFLD 123
Query: 253 QIVIEDIGNKRKYDFPLNRWLALDEDDGKIQRDILV-GGAETTAITYIVTVFTG 305
+VI+D +Y F +RWL EDD KI R++ + +A Y V F G
Sbjct: 124 DVVIKDPTTNYEYAFFCHRWLDQGEDDCKIVRELYARDNSIFSASRYHVYTFPG 177
Score = 108 bits (269), Expect = 8e-23
Identities = 66/183 (36%), Positives = 94/183 (51%), Gaps = 26/183 (14%)
Query: 1112 MNNEITYYFPCQRWLAVEEDDGQLSRELLPVDESY-VLPQSEEGRGGGDNNPLDNLALEQ 1170
MN+ +Y P QRWLA +++DG++ RE + + VLP
Sbjct: 1 MNSGKQFYVPVQRWLARDQEDGEICREFPLLSKGQPVLP--------------------- 39
Query: 1171 KDKSTTFSVTIKTGVKKNAGTDANVFITLFGTQDDTGMTLLKSSKTNSDKFERDSIEIFT 1230
T + V + TG NAGT ANV+I++ G + DTG L SK +S F R + F
Sbjct: 40 ---VTIYEVNVATGELWNAGTVANVYISIHGEKGDTGSRQLFRSK-SSFNFLRGQTDTFF 95
Query: 1231 VETLDLGDLWKVRLGHDNTGKAPGWFVDWVEVDAPSLGKCMTFPCGRWLAKNEDDGSIIR 1290
+E + LGDL K+ +GHD G GWF+D V + P+ F C RWL + EDD I+R
Sbjct: 96 LEAVHLGDLCKIVIGHDGLGPGNGWFLDDVVIKDPTTNYEYAFFCHRWLDQGEDDCKIVR 155
Query: 1291 DLF 1293
+L+
Sbjct: 156 ELY 158
Score = 108 bits (269), Expect = 8e-23
Identities = 72/203 (35%), Positives = 111/203 (54%), Gaps = 16/203 (7%)
Query: 263 RKYDFPLNRWLALDEDDGKIQRD--ILVGGAETTAIT-YIVTVFTGDVRGAGTKSKIYLV 319
+++ P+ RWLA D++DG+I R+ +L G +T Y V V TG++ AGT + +Y+
Sbjct: 5 KQFYVPVQRWLARDQEDGEICREFPLLSKGQPVLPVTIYEVNVATGELWNAGTVANVYIS 64
Query: 320 MYGARGNKNSGKIFLEGGVFD--RGRTDIFHIELAVLLSPLSRVSVGHGNVGVNRGWFCE 377
++G +G+ S ++F F+ RG+TD F +E AV L L ++ +GH +G GWF +
Sbjct: 65 IHGEKGDTGSRQLFRSKSSFNFLRGQTDTFFLE-AVHLGDLCKIVIGHDGLGPGNGWFLD 123
Query: 378 KVVILCPFTGIQQTFPCSNWLDEKKADGLIERQLY----EMVSLRKKRLKKFPWSLWVWT 433
VVI P T + F C WLD+ + D I R+LY + S + + FP L+
Sbjct: 124 DVVIKDPTTNYEYAFFCHRWLDQGEDDCKIVRELYARDNSIFSASRYHVYTFPGKLFY-- 181
Query: 434 TDLKKAGT---NSPIFIQIYGQK 453
D +K T N P+FI GQK
Sbjct: 182 DDWRKHDTSEINCPLFI-FSGQK 203
Score = 105 bits (263), Expect = 4e-22
Identities = 56/151 (37%), Positives = 88/151 (58%), Gaps = 3/151 (1%)
Query: 654 PCLRWLDKDKDDGQLVREL-LPSDSSATLKNFRYHISLKTGDVSGASTDSRVYIKLYGDK 712
P RWL +D++DG++ RE L S L Y +++ TG++ A T + VYI ++G+K
Sbjct: 10 PVQRWLARDQEDGEICREFPLLSKGQPVLPVTIYEVNVATGELWNAGTVANVYISIHGEK 69
Query: 713 SDTIKQVLLVSDNNLKDYFERGRVDEFTLETLNIGNINRLVIGHDSTGMHASWFLGSVQI 772
DT + L S ++ F RG+ D F LE +++G++ ++VIGHD G WFL V I
Sbjct: 70 GDTGSRQLFRSKSSFN--FLRGQTDTFFLEAVHLGDLCKIVIGHDGLGPGNGWFLDDVVI 127
Query: 773 RVPRQGKQYTFPANRWLDKNQADGRLEVELY 803
+ P +Y F +RWLD+ + D ++ ELY
Sbjct: 128 KDPTTNYEYAFFCHRWLDQGEDDCKIVRELY 158
Score = 99.0 bits (245), Expect = 5e-20
Identities = 57/170 (33%), Positives = 87/170 (51%), Gaps = 18/170 (10%)
Query: 1412 PCDRWLATSEDDKKTIRELVPYDIFTEKYMKDGSLRQVYKEVEEPLDIVLYSVQIFTGNI 1471
P RWLA ++D + RE + + + L + +Y V + TG +
Sbjct: 10 PVQRWLARDQEDGEICREF-----------------PLLSKGQPVLPVTIYEVNVATGEL 52
Query: 1472 PGAGTDAKVYITIYGDLGDTGERYLGKSENRTNKFERGTADTFIIEAADLGVIYKIKLRH 1531
AGT A VYI+I+G+ GDTG R L +S++ N F RG DTF +EA LG + KI + H
Sbjct: 53 WNAGTVANVYISIHGEKGDTGSRQLFRSKSSFN-FLRGQTDTFFLEAVHLGDLCKIVIGH 111
Query: 1532 DNSKWCADWYVEKVEIWNDTNEDEFLFLCGRWLSLKKEDGRLERLFYEKE 1581
D W+++ V I + T E+ F C RWL ++D ++ R Y ++
Sbjct: 112 DGLGPGNGWFLDDVVIKDPTTNYEYAFFCHRWLDQGEDDCKIVRELYARD 161
Score = 95.9 bits (237), Expect = 4e-19
Identities = 55/127 (43%), Positives = 75/127 (59%), Gaps = 2/127 (1%)
Query: 2084 SKVQSLVPVK-YEVIVTTGYEPGAGTDANVFVTIFGANGDTGKREL-KQKMRNLFERGST 2141
SK Q ++PV YEV V TG AGT ANV+++I G GDTG R+L + K F RG T
Sbjct: 32 SKGQPVLPVTIYEVNVATGELWNAGTVANVYISIHGEKGDTGSRQLFRSKSSFNFLRGQT 91
Query: 2142 DRFFLETLELGELRKVRLEHDSSGYCSGWLVEKVEVTNTSTGVATIFNCGRWLDKKRGDG 2201
D FFLE + LG+L K+ + HD G +GW ++ V + + +T F C RWLD+ D
Sbjct: 92 DTFFLEAVHLGDLCKIVIGHDGLGPGNGWFLDDVVIKDPTTNYEYAFFCHRWLDQGEDDC 151
Query: 2202 LTWRDLF 2208
R+L+
Sbjct: 152 KIVRELY 158
Score = 92.8 bits (229), Expect = 3e-18
Identities = 57/165 (34%), Positives = 85/165 (51%), Gaps = 1/165 (0%)
Query: 1783 MNTGDLTMFYYGDWLSQRKGKKTLVCEMCAVIDEEEMMEWTSYTVAVKTSDILGAGTDAN 1842
MN+G WL++ + + E + + ++ T Y V V T ++ AGT AN
Sbjct: 1 MNSGKQFYVPVQRWLARDQEDGEICREFPLLSKGQPVLPVTIYEVNVATGELWNAGTVAN 60
Query: 1843 VFIIIFGENGDSGTLALKQSANWNKFERNNTDTFNFPDMLSLGHLCKLRVWHDNKGIFPG 1902
V+I I GE GD+G+ L +S + F R TDTF F + + LG LCK+ + HD G G
Sbjct: 61 VYISIHGEKGDTGSRQLFRSKSSFNFLRGQTDTF-FLEAVHLGDLCKIVIGHDGLGPGNG 119
Query: 1903 WHLSYVDVKDNSRDETFHFQCDCWLSKSEGDGQTVRDFACANNKI 1947
W L V +KD + + + F C WL + E D + VR+ +N I
Sbjct: 120 WFLDDVVIKDPTTNYEYAFFCHRWLDQGEDDCKIVRELYARDNSI 164
Score = 90.5 bits (223), Expect = 2e-17
Identities = 64/227 (28%), Positives = 111/227 (48%), Gaps = 41/227 (18%)
Query: 422 LKKFPWSLWVWTTDLKKAGTNSPIFIQIYGQKGRTDEILLNPNN--KWFKPGIIEKFRIE 479
L + W + V T + GT + + + +YG KG T I L ++ + F PG ++F++
Sbjct: 535 LSEDEWKVLVLTGN---TGTQANVTLWVYGDKGVTGPISLRKDSSEQLFLPGHEDEFQV- 590
Query: 480 LPDLGRFYKIRVWHDKRSSGSGWHLERMTLMNTLNKDKYNFNCNRWLDANEDDNEIVREM 539
T+ + +K +F N WL + D ++V E+
Sbjct: 591 ----------------------------TMQHMKSKKILDFAANVWLSRIQADGDVVCEL 622
Query: 540 TAEGPTVR--RIMGMARYHVTVCTGELEGAGTDANVYLCLFGDVGDTGERLLYNCRNNTD 597
P V+ + + RY V V TG+L+ A T++ V+LCLFG+ GD+G R LY N
Sbjct: 623 ----PVVKGGQAIFPLRYQVDVYTGQLKHAETESEVFLCLFGERGDSGLRQLYK-SNMQV 677
Query: 598 LFEKGNADEFTIESVTMRNVRRVRIRHDGKGSGSGWYLDRVLVREEG 644
F++G D+F + +V++ +++V +R + WY ++V+VRE G
Sbjct: 678 KFQRGQIDKFQVAAVSLGKLQKVLLRCEASDKSQYWYCEQVIVREPG 724
Score = 90.1 bits (222), Expect = 2e-17
Identities = 53/126 (42%), Positives = 74/126 (58%), Gaps = 5/126 (3%)
Query: 778 GKQYTFPANRWLDKNQADGRLEVELYP--SEVVEIQKLVHYEVEIWTGDVGGAGTSARVY 835
GKQ+ P RWL ++Q DG + E +P S+ + + YEV + TG++ AGT A VY
Sbjct: 4 GKQFYVPVQRWLARDQEDGEICRE-FPLLSKGQPVLPVTIYEVNVATGELWNAGTVANVY 62
Query: 836 MQIYGEKGKT--EVLFLSSRSKVFERASKDTFQLEAADVGEVYKLRLGHTGEGFGPSWFV 893
+ I+GEKG T LF S S F R DTF LEA +G++ K+ +GH G G G WF+
Sbjct: 63 ISIHGEKGDTGSRQLFRSKSSFNFLRGQTDTFFLEAVHLGDLCKIVIGHDGLGPGNGWFL 122
Query: 894 DTVWLR 899
D V ++
Sbjct: 123 DDVVIK 128
Score = 88.6 bits (218), Expect = 6e-17
Identities = 59/181 (32%), Positives = 93/181 (51%), Gaps = 6/181 (3%)
Query: 386 TGIQQTFPCSNWLDEKKADGLIERQLYEMVSLRKKRLKKFPWSLWVWTTDLKKAGTNSPI 445
+G Q P WL + DG I R+ + ++S + L + + V T +L AGT + +
Sbjct: 3 SGKQFYVPVQRWLARDQEDGEICRE-FPLLSKGQPVLPVTIYEVNVATGELWNAGTVANV 61
Query: 446 FIQIYGQKGRTD--EILLNPNNKWFKPGIIEKFRIELPDLGRFYKIRVWHDKRSSGSGWH 503
+I I+G+KG T ++ + ++ F G + F +E LG KI + HD G+GW
Sbjct: 62 YISIHGEKGDTGSRQLFRSKSSFNFLRGQTDTFFLEAVHLGDLCKIVIGHDGLGPGNGWF 121
Query: 504 LERMTLMNTLNKDKYNFNCNRWLDANEDDNEIVREMTAEGPTVRRIMGMARYHVTVCTGE 563
L+ + + + +Y F C+RWLD EDD +IVRE+ A I +RYHV G+
Sbjct: 122 LDDVVIKDPTTNYEYAFFCHRWLDQGEDDCKIVRELYARD---NSIFSASRYHVYTFPGK 178
Query: 564 L 564
L
Sbjct: 179 L 179
Score = 84.0 bits (206), Expect = 2e-15
Identities = 68/214 (31%), Positives = 110/214 (51%), Gaps = 20/214 (9%)
Query: 950 DEGEEEESSSSEESSSEEEEMEEEEEEEEFGPGMQEVIEQH--KFEAHRWLARGKEDNEL 1007
D+G S ++SS E++ E+EF MQ + + F A+ WL+R + D ++
Sbjct: 562 DKGVTGPISLRKDSS---EQLFLPGHEDEFQVTMQHMKSKKILDFAANVWLSRIQADGDV 618
Query: 1008 VVELVPAGKPG----PERNTYEVQVVTGNVPKAGTDANVYLTIYGEEYGDTGERPLKKSD 1063
V EL P K G P R Y+V V TG + A T++ V+L ++GE GD+G R L KS+
Sbjct: 619 VCEL-PVVKGGQAIFPLR--YQVDVYTGQLKHAETESEVFLCLFGER-GDSGLRQLYKSN 674
Query: 1064 KSNKFEQGQTDTFTIYAIDLGALTKIRIRHDNTGNRAGWFLDRIDITDMNNEITYYFPCQ 1123
KF++GQ D F + A+ LG L K+ +R + + W+ +++ + + F CQ
Sbjct: 675 MQVKFQRGQIDKFQVAAVSLGKLQKVLLRCEASDKSQYWYCEQVIVREPGTTSESIFTCQ 734
Query: 1124 RWLAVEEDDGQLSRELLPVDE----SYVLPQSEE 1153
++ + Q S +L DE S +L +EE
Sbjct: 735 ---SLPAHNFQASPSMLYRDETVPTSLILKGAEE 765
Score = 83.2 bits (204), Expect = 3e-15
Identities = 54/165 (32%), Positives = 84/165 (50%), Gaps = 13/165 (7%)
Query: 27 ASEDDEGELEHEY---------YKARVYEVVTATGDVRGAGTDANVFITLFGENGLSPKL 77
A + ++GE+ E+ +YEV ATG++ AGT ANV+I++ GE G +
Sbjct: 16 ARDQEDGEICREFPLLSKGQPVLPVTIYEVNVATGELWNAGTVANVYISIHGEKGDTGSR 75
Query: 78 QL-TSKSKSAFEKGNVDVFRVRTNNVGLIYKVRIEHDNTGLNASWYLDHVIVTDMKRPHL 136
QL SKS F +G D F + ++G + K+ I HD G W+LD V++ D +
Sbjct: 76 QLFRSKSSFNFLRGQTDTFFLEAVHLGDLCKIVIGHDGLGPGNGWFLDDVVIKD-PTTNY 134
Query: 137 RYYFNCNNWLSKVEGDRQWCRDLLASFNPMDMPRGNKYEVKVYTG 181
Y F C+ WL + E D + R+L A N + ++Y V + G
Sbjct: 135 EYAFFCHRWLDQGEDDCKIVRELYARDN--SIFSASRYHVYTFPG 177
Score = 79.3 bits (194), Expect = 4e-14
Identities = 58/221 (26%), Positives = 106/221 (47%), Gaps = 37/221 (16%)
Query: 555 YHVTVCTGELEGAGTDANVYLCLFGDVGDTGERLLYNCRNNTDLFEKGNADEFTIESVTM 614
+ V V TG GT ANV L ++GD G TG L ++ LF G+ DEF VTM
Sbjct: 540 WKVLVLTGN---TGTQANVTLWVYGDKGVTGPISLRK-DSSEQLFLPGHEDEF---QVTM 592
Query: 615 RNVRRVRIRHDGKGSGSGWYLDRVLVREEGQPESDNVEFPCLRWLDKDKDDGQLVRELLP 674
++++ +I ++F WL + + DG +V EL
Sbjct: 593 QHMKSKKI----------------------------LDFAANVWLSRIQADGDVVCELPV 624
Query: 675 SDSSATLKNFRYHISLKTGDVSGASTDSRVYIKLYGDKSDTIKQVLLVSDNNLKDYFERG 734
+ RY + + TG + A T+S V++ L+G++ D+ + L S+ +K F+RG
Sbjct: 625 VKGGQAIFPLRYQVDVYTGQLKHAETESEVFLCLFGERGDSGLRQLYKSNMQVK--FQRG 682
Query: 735 RVDEFTLETLNIGNINRLVIGHDSTGMHASWFLGSVQIRVP 775
++D+F + +++G + ++++ +++ W+ V +R P
Sbjct: 683 QIDKFQVAAVSLGKLQKVLLRCEASDKSQYWYCEQVIVREP 723
Score = 79.0 bits (193), Expect = 5e-14
Identities = 59/231 (25%), Positives = 110/231 (47%), Gaps = 39/231 (16%)
Query: 172 NKYEVKVYTGDVIGAGTDADVFINIFGEYGDTG--ERRLENEKDNFEKGAEDRFILDAPD 229
++++V V TG+ GT A+V + ++G+ G TG R ++ + F G ED F
Sbjct: 538 DEWKVLVLTGNT---GTQANVTLWVYGDKGVTGPISLRKDSSEQLFLPGHEDEF------ 588
Query: 230 LGQLMKINVGHNNKGGSAGWFLSQIVIEDIGNKRKYDFPLNRWLALDEDDGKI--QRDIL 287
Q+ ++ + +K+ DF N WL+ + DG + + ++
Sbjct: 589 -----------------------QVTMQHMKSKKILDFAANVWLSRIQADGDVVCELPVV 625
Query: 288 VGGAETTAITYIVTVFTGDVRGAGTKSKIYLVMYGARGNKNSGKIFLEG--GVFDRGRTD 345
GG + Y V V+TG ++ A T+S+++L ++G RG+ +++ F RG+ D
Sbjct: 626 KGGQAIFPLRYQVDVYTGQLKHAETESEVFLCLFGERGDSGLRQLYKSNMQVKFQRGQID 685
Query: 346 IFHIELAVLLSPLSRVSVGHGNVGVNRGWFCEKVVILCPFTGIQQTFPCSN 396
F + AV L L +V + ++ W+CE+V++ P T + F C +
Sbjct: 686 KFQV-AAVSLGKLQKVLLRCEASDKSQYWYCEQVIVREPGTTSESIFTCQS 735
Score = 77.4 bits (189), Expect = 1e-13
Identities = 56/167 (33%), Positives = 81/167 (48%), Gaps = 9/167 (5%)
Query: 1268 GKCMTFPCGRWLAKNEDDGSIIRDLFHAELQTRLYTPFVPYEITLYTSDVFAAGTDANIF 1327
GK P RWLA++++DG I R+ F + + P YE+ + T +++ AGT AN++
Sbjct: 4 GKQFYVPVQRWLARDQEDGEICRE-FPLLSKGQPVLPVTIYEVNVATGELWNAGTVANVY 62
Query: 1328 IIIYGCDAVCTQQKYLCTNKREQKQFFERKSASRFIVELEDVGEIIEKIRIGHNNTGMNP 1387
I I+G + T + L +K F R F +E +G++ KI IGH+ G
Sbjct: 63 ISIHG-EKGDTGSRQLFRSKSSFN--FLRGQTDTFFLEAVHLGDLC-KIVIGHDGLGPGN 118
Query: 1388 GWHCSHVDIRRLLPDKDGAETLTFPCDRWLATSEDDKKTIRELVPYD 1434
GW V I+ D F C RWL EDD K +REL D
Sbjct: 119 GWFLDDVVIK----DPTTNYEYAFFCHRWLDQGEDDCKIVRELYARD 161
Score = 75.5 bits (184), Expect = 5e-13
Identities = 89/394 (22%), Positives = 160/394 (40%), Gaps = 54/394 (13%)
Query: 670 RELLPSDSSATLKNFRYHISLKTGD-------VSGASTDSRVYIKLYGDKSDTIKQVLLV 722
R LPS ++ +++F+ +L + D T + V + +YGDK T + L
Sbjct: 514 RSPLPSSTAKEIRHFQSSETLLSEDEWKVLVLTGNTGTQANVTLWVYGDKGVT-GPISLR 572
Query: 723 SDNNLKDYFERGRVDEFTLETLNIGNINRLVIGHDSTGMHASWFLGSVQIRVPRQGKQYT 782
D++ + F G DEF V ++ + K
Sbjct: 573 KDSS-EQLFLPGHEDEF-----------------------------QVTMQHMKSKKILD 602
Query: 783 FPANRWLDKNQADGRLEVELYPSEVVEIQKLVHYEVEIWTGDVGGAGTSARVYMQIYGEK 842
F AN WL + QADG + EL + + + Y+V+++TG + A T + V++ ++GE+
Sbjct: 603 FAANVWLSRIQADGDVVCELPVVKGGQAIFPLRYQVDVYTGQLKHAETESEVFLCLFGER 662
Query: 843 GKTEV--LFLSSRSKVFERASKDTFQLEAADVGEVYKLRLGHTGEGFGPSWFVDTVWLRH 900
G + + L+ S+ F+R D FQ+ A +G++ K+ L W+ + V
Sbjct: 663 GDSGLRQLYKSNMQVKFQRGQIDKFQVAAVSLGKLQKVLLRCEASDKSQYWYCEQV---- 718
Query: 901 LVVREVDLTPE-----EEARKKKEKDKLRQLLKKERLKAKLQRKKKKRKGSDEEDEGEEE 955
+VRE T E + + L + E + L K + G+ G
Sbjct: 719 -IVREPGTTSESIFTCQSLPAHNFQASPSMLYRDETVPTSLILKGAEEYGTRNRTWG--T 775
Query: 956 ESSSSEESSSEEEEMEEEEEEEEFGPGMQEVIEQHKFEAHRWLARGKEDNELVVELVPAG 1015
S + + + + + + + H A + + + KE + EL
Sbjct: 776 AGSFLLQKKAILKPLIVTSVSQSLFCAYEVKVSVH--GAWKAVLKRKESHGFTQELEWTV 833
Query: 1016 KPGPERNTYEVQVVTGNVPKAGTDANVYLTIYGE 1049
G ++V +VTG++ AGT A V+L +YGE
Sbjct: 834 LAGELDGDWKVTIVTGDLENAGTTATVFLYVYGE 867
Score = 74.3 bits (181), Expect = 1e-12
Identities = 83/331 (25%), Positives = 129/331 (38%), Gaps = 70/331 (21%)
Query: 952 GEEEESSSSEESSSEEEEMEEEEEEEEFGPGMQEVIEQHKFEAHRWLARGKEDNELVVEL 1011
G E S S EEE++ E +++++ P + A R + +E ++
Sbjct: 480 GRENPMGMSATPSQEEEKIHESKKQKKIPPESEARSPLPSSTAKE--IRHFQSSETLLS- 536
Query: 1012 VPAGKPGPERNTYEVQVVTGNVPKAGTDANVYLTIYGEEYGDTGERPLKKSDKSNKFEQG 1071
+ ++V V+TGN GT ANV L +YG++ G TG L+K F G
Sbjct: 537 ---------EDEWKVLVLTGNT---GTQANVTLWVYGDK-GVTGPISLRKDSSEQLFLPG 583
Query: 1072 QTDTFTIYAIDLGALTKIRIRHDNTGNRAGWFLDRIDITDMNNEITYYFPCQRWLAVEED 1131
D F ++ + M ++ F WL+ +
Sbjct: 584 HEDEF-----------------------------QVTMQHMKSKKILDFAANVWLSRIQA 614
Query: 1132 DGQLSRELLPVDESYVLPQSEEGRGGGDNNPLDNLALEQKDKSTTFSVTIKTGVKKNAGT 1191
DG + EL V +GG PL + V + TG K+A T
Sbjct: 615 DGDVVCELPVV------------KGGQAIFPL------------RYQVDVYTGQLKHAET 650
Query: 1192 DANVFITLFGTQDDTGMTLLKSSKTNSDKFERDSIEIFTVETLDLGDLWKVRLGHDNTGK 1251
++ VF+ LFG + D+G+ L S KF+R I+ F V + LG L KV L + + K
Sbjct: 651 ESEVFLCLFGERGDSGLRQLYKSNMQV-KFQRGQIDKFQVAAVSLGKLQKVLLRCEASDK 709
Query: 1252 APGWFVDWVEVDAPSLGKCMTFPCGRWLAKN 1282
+ W+ + V V P F C A N
Sbjct: 710 SQYWYCEQVIVREPGTTSESIFTCQSLPAHN 740
Score = 74.3 bits (181), Expect = 1e-12
Identities = 59/220 (26%), Positives = 104/220 (47%), Gaps = 39/220 (17%)
Query: 45 YEVVTATGDVRGAGTDANVFITLFGENGLSPKLQLTS-KSKSAFEKGNVDVFRVRTNNVG 103
++V+ TG+ GT ANV + ++G+ G++ + L S+ F G+ D F+V +
Sbjct: 540 WKVLVLTGNT---GTQANVTLWVYGDKGVTGPISLRKDSSEQLFLPGHEDEFQVTMQH-- 594
Query: 104 LIYKVRIEHDNTGLNASWYLDHVIVTDMKRPHLRYYFNCNNWLSKVEGDRQWCRDL-LAS 162
+ + LD F N WLS+++ D +L +
Sbjct: 595 -------------MKSKKILD---------------FAANVWLSRIQADGDVVCELPVVK 626
Query: 163 FNPMDMPRGNKYEVKVYTGDVIGAGTDADVFINIFGEYGDTGERRL--ENEKDNFEKGAE 220
P +Y+V VYTG + A T+++VF+ +FGE GD+G R+L N + F++G
Sbjct: 627 GGQAIFPL--RYQVDVYTGQLKHAETESEVFLCLFGERGDSGLRQLYKSNMQVKFQRGQI 684
Query: 221 DRFILDAPDLGQLMKINVGHNNKGGSAGWFLSQIVIEDIG 260
D+F + A LG+L K+ + S W+ Q+++ + G
Sbjct: 685 DKFQVAAVSLGKLQKVLLRCEASDKSQYWYCEQVIVREPG 724
Score = 73.9 bits (180), Expect = 2e-12
Identities = 40/105 (38%), Positives = 62/105 (59%), Gaps = 1/105 (0%)
Query: 2087 QSLVPVKYEVIVTTGYEPGAGTDANVFVTIFGANGDTGKREL-KQKMRNLFERGSTDRFF 2145
Q++ P++Y+V V TG A T++ VF+ +FG GD+G R+L K M+ F+RG D+F
Sbjct: 629 QAIFPLRYQVDVYTGQLKHAETESEVFLCLFGERGDSGLRQLYKSNMQVKFQRGQIDKFQ 688
Query: 2146 LETLELGELRKVRLEHDSSGYCSGWLVEKVEVTNTSTGVATIFNC 2190
+ + LG+L+KV L ++S W E+V V T +IF C
Sbjct: 689 VAAVSLGKLQKVLLRCEASDKSQYWYCEQVIVREPGTTSESIFTC 733
Score = 71.6 bits (174), Expect = 8e-12
Identities = 39/118 (33%), Positives = 65/118 (55%), Gaps = 2/118 (1%)
Query: 1697 LYEMTVWTGDVVGGGTDSNIFMTLYGINGSTEEMQLDKKKARFE--REQNDTFIMEILDI 1754
+YE+ V TG++ GT +N++++++G G T QL + K+ F R Q DTF +E + +
Sbjct: 42 IYEVNVATGELWNAGTVANVYISIHGEKGDTGSRQLFRSKSSFNFLRGQTDTFFLEAVHL 101
Query: 1755 APFTKMRIRIDGLGSRPEWFLERILLKNMNTGDLTMFYYGDWLSQRKGKKTLVCEMCA 1812
K+ I DGLG WFL+ +++K+ T F+ WL Q + +V E+ A
Sbjct: 102 GDLCKIVIGHDGLGPGNGWFLDDVVIKDPTTNYEYAFFCHRWLDQGEDDCKIVRELYA 159
Score = 68.9 bits (167), Expect = 5e-11
Identities = 36/99 (36%), Positives = 56/99 (56%), Gaps = 1/99 (1%)
Query: 1462 YSVQIFTGNIPGAGTDAKVYITIYGDLGDTGERYLGKSENRTNKFERGTADTFIIEAADL 1521
Y V ++TG + A T+++V++ ++G+ GD+G R L KS N KF+RG D F + A L
Sbjct: 636 YQVDVYTGQLKHAETESEVFLCLFGERGDSGLRQLYKS-NMQVKFQRGQIDKFQVAAVSL 694
Query: 1522 GVIYKIKLRHDNSKWCADWYVEKVEIWNDTNEDEFLFLC 1560
G + K+ LR + S WY E+V + E +F C
Sbjct: 695 GKLQKVLLRCEASDKSQYWYCEQVIVREPGTTSESIFTC 733
Score = 58.2 bits (139), Expect = 9e-08
Identities = 56/228 (24%), Positives = 93/228 (40%), Gaps = 36/228 (15%)
Query: 1698 YEMTVWTGDVVGGGTDSNIFMTLYGINGSTEEMQL--DKKKARFEREQNDTFIMEILDIA 1755
+++ V TG+ GT +N+ + +YG G T + L D + F D F
Sbjct: 540 WKVLVLTGNT---GTQANVTLWVYGDKGVTGPISLRKDSSEQLFLPGHEDEF-------- 588
Query: 1756 PFTKMRIRIDGLGSRPEWFLERILLKNMNTGDLTMFYYGDWLSQRKGKKTLVCEMCAVID 1815
++ +++M + + F WLS+ + +VCE+ V
Sbjct: 589 ---------------------QVTMQHMKSKKILDFAANVWLSRIQADGDVVCELPVVKG 627
Query: 1816 EEEMMEWTSYTVAVKTSDILGAGTDANVFIIIFGENGDSGTLALKQSANWNKFERNNTDT 1875
+ + Y V V T + A T++ VF+ +FGE GDSG L +S KF+R D
Sbjct: 628 GQAIFP-LRYQVDVYTGQLKHAETESEVFLCLFGERGDSGLRQLYKSNMQVKFQRGQIDK 686
Query: 1876 FNFPDMLSLGHLCKLRVWHDNKGIFPGWHLSYVDVKDNSRDETFHFQC 1923
F +SLG L K+ + + W+ V V++ F C
Sbjct: 687 FQVA-AVSLGKLQKVLLRCEASDKSQYWYCEQVIVREPGTTSESIFTC 733
Score = 55.8 bits (133), Expect = 4e-07
Identities = 40/142 (28%), Positives = 65/142 (45%), Gaps = 11/142 (7%)
Query: 1919 FHFQCDCWLSKSEGDGQTVRDFACANNKICDELEETTYEIVIETG---NGGETRENVWLI 1975
F+ WL++ + DG+ R+F + K L T YE+ + TG N G T NV++
Sbjct: 7 FYVPVQRWLARDQEDGEICREFPLLS-KGQPVLPVTIYEVNVATGELWNAG-TVANVYIS 64
Query: 1976 LEGRKNRSKEFLMENSSRQRAFRKGTTDTFEFDSIYLGDIASLCVGHLAREDRFIPKREL 2035
+ G K + + S F +G TDTF ++++LGD+ + +GH D P
Sbjct: 65 IHGEKGDTGSRQLFRSKSSFNFLRGQTDTFFLEAVHLGDLCKIVIGH----DGLGPGN-- 118
Query: 2036 AWHVKTITITEMEYGNVYFFNC 2057
W + + I + Y F C
Sbjct: 119 GWFLDDVVIKDPTTNYEYAFFC 140
Score = 53.5 bits (127), Expect = 2e-06
Identities = 97/443 (21%), Positives = 162/443 (36%), Gaps = 118/443 (26%)
Query: 1462 YSVQIFTGNIPGAGTDAKVYITIYGDLGDTGERYLGKSENRTNKFERGTADTFIIEAADL 1521
+ V + TGN GT A V + +YGD G TG L K + F G D F
Sbjct: 540 WKVLVLTGN---TGTQANVTLWVYGDKGVTGPISLRKDSSE-QLFLPGHEDEF------- 588
Query: 1522 GVIYKIKLRHDNSKWCADWYVEKVEIWNDTNEDEFLFLCGRWLSLKKEDGRLERLFYEKE 1581
++ ++H SK D F WLS + DG +
Sbjct: 589 ----QVTMQHMKSKKILD------------------FAANVWLSRIQADGDVV------- 619
Query: 1582 YTGDRSSNCSSPADFWEIALSSKMADVDISTVTGPMADYVQEGPIIPYYVSVTTGKHKDA 1641
C P V G A + + Y V V TG+ K A
Sbjct: 620 --------CELPV------------------VKGGQAIFP-----LRYQVDVYTGQLKHA 648
Query: 1642 ATDSRAFIFLIGE-DDERSKRIWLDYPRGKRGFSRGSVEEFYVAGLDVGIIKKI----EV 1696
T+S F+ L GE D ++++ + K F RG +++F VA + +G ++K+ E
Sbjct: 649 ETESEVFLCLFGERGDSGLRQLYKSNMQVK--FQRGQIDKFQVAAVSLGKLQKVLLRCEA 706
Query: 1697 LYEMTVWTGDVV----GGGTDSNIFMTLYGINGSTEEMQLDKKKARFEREQNDTFIMEIL 1752
+ W + V G T +IF + + + +A D + L
Sbjct: 707 SDKSQYWYCEQVIVREPGTTSESIF--------TCQSLPAHNFQASPSMLYRDETVPTSL 758
Query: 1753 DIAPFTKMRIRIDGLGSRPEWFLER------ILLKNMNTG-----DLTMFYYGDWLSQRK 1801
+ + R G+ + L++ +++ +++ ++ + +G W + K
Sbjct: 759 ILKGAEEYGTRNRTWGTAGSFLLQKKAILKPLIVTSVSQSLFCAYEVKVSVHGAWKAVLK 818
Query: 1802 GKKTLVCEMCAVIDEEEMMEWT--------SYTVAVKTSDILGAGTDANVFIIIFGENGD 1853
K++ + +EWT + V + T D+ AGT A VF+ ++GE
Sbjct: 819 RKES--------HGFTQELEWTVLAGELDGDWKVTIVTGDLENAGTTATVFLYVYGETKC 870
Query: 1854 SGTLALKQSANWNKFERNNTDTF 1876
SG + L S F N D F
Sbjct: 871 SGPIIL-GSGKHQLFNPNTADIF 892
Score = 49.3 bits (116), Expect = 4e-05
Identities = 49/246 (19%), Positives = 98/246 (39%), Gaps = 43/246 (17%)
Query: 1817 EEMMEWTSYTVAVKTSDILGAGTDANVFIIIFGENGDSGTLALKQSANWNKFERNNTDTF 1876
E ++ + V V T + GT ANV + ++G+ G +G ++L++ ++ F + D F
Sbjct: 532 ETLLSEDEWKVLVLTGN---TGTQANVTLWVYGDKGVTGPISLRKDSSEQLFLPGHEDEF 588
Query: 1877 NFPDMLSLGHLCKLRVWHDNKGIFPGWHLSYVDVKDNSRDETFHFQCDCWLSKSEGDGQT 1936
+++ H+ ++ F + WLS+ + DG
Sbjct: 589 Q----VTMQHMKSKKI--------------------------LDFAANVWLSRIQADGDV 618
Query: 1937 VRDFACANNKICDELEETTYEIVIETG--NGGETRENVWLILEGRKNRSKEFLMENSSRQ 1994
V + K + Y++ + TG ET V+L L G + S + S+ Q
Sbjct: 619 VCELPVV--KGGQAIFPLRYQVDVYTGQLKHAETESEVFLCLFGERGDSGLRQLYKSNMQ 676
Query: 1995 RAFRKGTTDTFEFDSIYLGDIASLCVGHLAREDRFIPKRELAWHVKTITITEMEYGNVYF 2054
F++G D F+ ++ LG + + + A + + W+ + + + E +
Sbjct: 677 VKFQRGQIDKFQVAAVSLGKLQKVLLRCEASD------KSQYWYCEQVIVREPGTTSESI 730
Query: 2055 FNCDCL 2060
F C L
Sbjct: 731 FTCQSL 736
Score = 44.3 bits (103), Expect = 0.001
Identities = 34/135 (25%), Positives = 63/135 (46%), Gaps = 8/135 (5%)
Query: 392 FPCSNWLDEKKADGLIERQLYEMVSLRKKRLKKFP--WSLWVWTTDLKKAGTNSPIFIQI 449
F + WL +ADG + +L + K FP + + V+T LK A T S +F+ +
Sbjct: 603 FAANVWLSRIQADGDVVCEL----PVVKGGQAIFPLRYQVDVYTGQLKHAETESEVFLCL 658
Query: 450 YGQKGRTDEILLNPNNKW--FKPGIIEKFRIELPDLGRFYKIRVWHDKRSSGSGWHLERM 507
+G++G + L +N F+ G I+KF++ LG+ K+ + + W+ E++
Sbjct: 659 FGERGDSGLRQLYKSNMQVKFQRGQIDKFQVAAVSLGKLQKVLLRCEASDKSQYWYCEQV 718
Query: 508 TLMNTLNKDKYNFNC 522
+ + F C
Sbjct: 719 IVREPGTTSESIFTC 733
Score = 40.8 bits (94), Expect = 0.015
Identities = 44/221 (19%), Positives = 95/221 (42%), Gaps = 39/221 (17%)
Query: 1177 FSVTIKTGVKKNAGTDANVFITLFGTQDDTGMTLLKSSKTNSDKFERDSIEIFTVETLDL 1236
+ V + TG N GT ANV + ++G + TG L+ +DS E +
Sbjct: 540 WKVLVLTG---NTGTQANVTLWVYGDKGVTGPISLR----------KDSSEQLFLP---- 582
Query: 1237 GDLWKVRLGHDNTGKAPGWFVDWVEVDAPSLGKCMTFPCGRWLAKNEDDGSIIRDLFHAE 1296
GH++ + V + K + F WL++ + DG ++ +L +
Sbjct: 583 --------GHEDEFQ--------VTMQHMKSKKILDFAANVWLSRIQADGDVVCELPVVK 626
Query: 1297 LQTRLYTPFVPYEITLYTSDVFAAGTDANIFIIIYGCDAVCTQQKYLCTNKREQKQFFER 1356
++ + Y++ +YT + A T++ +F+ ++G ++ +N + + F+R
Sbjct: 627 GGQAIFP--LRYQVDVYTGQLKHAETESEVFLCLFGERGDSGLRQLYKSNMQVK---FQR 681
Query: 1357 KSASRFIVELEDVGEIIEKIRIGHNNTGMNPGWHCSHVDIR 1397
+F V +G+ ++K+ + + + W+C V +R
Sbjct: 682 GQIDKFQVAAVSLGK-LQKVLLRCEASDKSQYWYCEQVIVR 721
Score = 39.3 bits (90), Expect = 0.043
Identities = 21/55 (38%), Positives = 34/55 (61%), Gaps = 8/55 (14%)
Query: 555 YHVTVCTGELEGAGTDANVYLCLFGD-------VGDTGERLLYNCRNNTDLFEKG 602
+ VT+ TG+LE AGT A V+L ++G+ + +G+ L+N N D+F+KG
Sbjct: 842 WKVTIVTGDLENAGTTATVFLYVYGETKCSGPIILGSGKHQLFN-PNTADIFKKG 895
Score = 38.5 bits (88), Expect = 0.074
Identities = 18/52 (34%), Positives = 27/52 (51%)
Query: 45 YEVVTATGDVRGAGTDANVFITLFGENGLSPKLQLTSKSKSAFEKGNVDVFR 96
++V TGD+ AGT A VF+ ++GE S + L S F D+F+
Sbjct: 842 WKVTIVTGDLENAGTTATVFLYVYGETKCSGPIILGSGKHQLFNPNTADIFK 893
Score = 36.2 bits (82), Expect = 0.37
Identities = 21/51 (41%), Positives = 29/51 (56%), Gaps = 5/51 (9%)
Query: 300 VTVFTGDVRGAGTKSKIYLVMYGARGNKNSGKIFLEGG---VFDRGRTDIF 347
VT+ TGD+ AGT + ++L +YG K SG I L G +F+ DIF
Sbjct: 844 VTIVTGDLENAGTTATVFLYVYGE--TKCSGPIILGSGKHQLFNPNTADIF 892
Score = 35.4 bits (80), Expect = 0.63
Identities = 18/52 (34%), Positives = 32/52 (61%), Gaps = 1/52 (1%)
Query: 816 YEVEIWTGDVGGAGTSARVYMQIYGE-KGKTEVLFLSSRSKVFERASKDTFQ 866
++V I TGD+ AGT+A V++ +YGE K ++ S + ++F + D F+
Sbjct: 842 WKVTIVTGDLENAGTTATVFLYVYGETKCSGPIILGSGKHQLFNPNTADIFK 893
Score = 33.5 bits (75), Expect = 2.4
Identities = 20/53 (37%), Positives = 30/53 (56%), Gaps = 2/53 (3%)
Query: 1177 FSVTIKTGVKKNAGTDANVFITLFGTQDDTGMTLLKSSKTNSDKFERDSIEIF 1229
+ VTI TG +NAGT A VF+ ++G +G +L S K F ++ +IF
Sbjct: 842 WKVTIVTGDLENAGTTATVFLYVYGETKCSGPIILGSGK--HQLFNPNTADIF 892
Score = 32.7 bits (73), Expect = 4.1
Identities = 24/69 (34%), Positives = 31/69 (44%), Gaps = 4/69 (5%)
Query: 2077 KTTESFASKVQSLVPVKYEVIVTTGYEPGAGTDANVFVTIFGANGDTGKREL-KQKMRNL 2135
K F S L +++V+V TG GT ANV + ++G G TG L K L
Sbjct: 523 KEIRHFQSSETLLSEDEWKVLVLTG---NTGTQANVTLWVYGDKGVTGPISLRKDSSEQL 579
Query: 2136 FERGSTDRF 2144
F G D F
Sbjct: 580 FLPGHEDEF 588
>gi|239749428 PREDICTED: hypothetical protein XP_002347033 [Homo
sapiens]
Length = 1029
Score = 127 bits (319), Expect = 1e-28
Identities = 75/160 (46%), Positives = 92/160 (57%), Gaps = 3/160 (1%)
Query: 988 EQHKFEAHRWLARGKEDNELVVE--LVPAGKPGPERNTYEVQVVTGNVPKAGTDANVYLT 1045
+Q RWLAR +ED E+ E L+ G+P YEV V TG + AGT ANVY++
Sbjct: 5 KQFYVPVQRWLARDQEDGEICREFPLLSKGQPVLPVTIYEVNVATGELWNAGTVANVYIS 64
Query: 1046 IYGEEYGDTGERPLKKSDKSNKFEQGQTDTFTIYAIDLGALTKIRIRHDNTGNRAGWFLD 1105
I+GE+ GDTG R L +S S F +GQTDTF + A+ LG L KI I HD G GWFLD
Sbjct: 65 IHGEK-GDTGSRQLFRSKSSFNFLRGQTDTFFLEAVHLGDLCKIVIGHDGLGPGNGWFLD 123
Query: 1106 RIDITDMNNEITYYFPCQRWLAVEEDDGQLSRELLPVDES 1145
+ I D Y F C RWL EDD ++ REL D S
Sbjct: 124 DVVIKDPTTNYEYAFFCHRWLDQGEDDCKIVRELYARDNS 163
Score = 115 bits (287), Expect = 6e-25
Identities = 67/169 (39%), Positives = 104/169 (61%), Gaps = 13/169 (7%)
Query: 524 RWLDANEDDNEIVRE--MTAEGPTVRRIMGMARYHVTVCTGELEGAGTDANVYLCLFGDV 581
RWL +++D EI RE + ++G V + + Y V V TGEL AGT ANVY+ + G+
Sbjct: 13 RWLARDQEDGEICREFPLLSKGQPV---LPVTIYEVNVATGELWNAGTVANVYISIHGEK 69
Query: 582 GDTGERLLYNCRNNTDLFEKGNADEFTIESVTMRNVRRVRIRHDGKGSGSGWYLDRVLVR 641
GDTG R L+ +++ + F +G D F +E+V + ++ ++ I HDG G G+GW+LD V+++
Sbjct: 70 GDTGSRQLFRSKSSFN-FLRGQTDTFFLEAVHLGDLCKIVIGHDGLGPGNGWFLDDVVIK 128
Query: 642 EEGQPESDNVE--FPCLRWLDKDKDDGQLVRELLPSDSSATLKNFRYHI 688
+ + N E F C RWLD+ +DD ++VREL D+S RYH+
Sbjct: 129 D----PTTNYEYAFFCHRWLDQGEDDCKIVRELYARDNS-IFSASRYHV 172
Score = 110 bits (275), Expect = 2e-23
Identities = 70/174 (40%), Positives = 98/174 (56%), Gaps = 7/174 (4%)
Query: 137 RYYFNCNNWLSKVEGDRQWCRD--LLASFNPMDMPRGNKYEVKVYTGDVIGAGTDADVFI 194
++Y WL++ + D + CR+ LL+ P+ +P YEV V TG++ AGT A+V+I
Sbjct: 6 QFYVPVQRWLARDQEDGEICREFPLLSKGQPV-LPV-TIYEVNVATGELWNAGTVANVYI 63
Query: 195 NIFGEYGDTGERRLENEKD--NFEKGAEDRFILDAPDLGQLMKINVGHNNKGGSAGWFLS 252
+I GE GDTG R+L K NF +G D F L+A LG L KI +GH+ G GWFL
Sbjct: 64 SIHGEKGDTGSRQLFRSKSSFNFLRGQTDTFFLEAVHLGDLCKIVIGHDGLGPGNGWFLD 123
Query: 253 QIVIEDIGNKRKYDFPLNRWLALDEDDGKIQRDILV-GGAETTAITYIVTVFTG 305
+VI+D +Y F +RWL EDD KI R++ + +A Y V F G
Sbjct: 124 DVVIKDPTTNYEYAFFCHRWLDQGEDDCKIVRELYARDNSIFSASRYHVYTFPG 177
Score = 108 bits (269), Expect = 8e-23
Identities = 66/183 (36%), Positives = 94/183 (51%), Gaps = 26/183 (14%)
Query: 1112 MNNEITYYFPCQRWLAVEEDDGQLSRELLPVDESY-VLPQSEEGRGGGDNNPLDNLALEQ 1170
MN+ +Y P QRWLA +++DG++ RE + + VLP
Sbjct: 1 MNSGKQFYVPVQRWLARDQEDGEICREFPLLSKGQPVLP--------------------- 39
Query: 1171 KDKSTTFSVTIKTGVKKNAGTDANVFITLFGTQDDTGMTLLKSSKTNSDKFERDSIEIFT 1230
T + V + TG NAGT ANV+I++ G + DTG L SK +S F R + F
Sbjct: 40 ---VTIYEVNVATGELWNAGTVANVYISIHGEKGDTGSRQLFRSK-SSFNFLRGQTDTFF 95
Query: 1231 VETLDLGDLWKVRLGHDNTGKAPGWFVDWVEVDAPSLGKCMTFPCGRWLAKNEDDGSIIR 1290
+E + LGDL K+ +GHD G GWF+D V + P+ F C RWL + EDD I+R
Sbjct: 96 LEAVHLGDLCKIVIGHDGLGPGNGWFLDDVVIKDPTTNYEYAFFCHRWLDQGEDDCKIVR 155
Query: 1291 DLF 1293
+L+
Sbjct: 156 ELY 158
Score = 108 bits (269), Expect = 8e-23
Identities = 72/203 (35%), Positives = 111/203 (54%), Gaps = 16/203 (7%)
Query: 263 RKYDFPLNRWLALDEDDGKIQRD--ILVGGAETTAIT-YIVTVFTGDVRGAGTKSKIYLV 319
+++ P+ RWLA D++DG+I R+ +L G +T Y V V TG++ AGT + +Y+
Sbjct: 5 KQFYVPVQRWLARDQEDGEICREFPLLSKGQPVLPVTIYEVNVATGELWNAGTVANVYIS 64
Query: 320 MYGARGNKNSGKIFLEGGVFD--RGRTDIFHIELAVLLSPLSRVSVGHGNVGVNRGWFCE 377
++G +G+ S ++F F+ RG+TD F +E AV L L ++ +GH +G GWF +
Sbjct: 65 IHGEKGDTGSRQLFRSKSSFNFLRGQTDTFFLE-AVHLGDLCKIVIGHDGLGPGNGWFLD 123
Query: 378 KVVILCPFTGIQQTFPCSNWLDEKKADGLIERQLY----EMVSLRKKRLKKFPWSLWVWT 433
VVI P T + F C WLD+ + D I R+LY + S + + FP L+
Sbjct: 124 DVVIKDPTTNYEYAFFCHRWLDQGEDDCKIVRELYARDNSIFSASRYHVYTFPGKLFY-- 181
Query: 434 TDLKKAGT---NSPIFIQIYGQK 453
D +K T N P+FI GQK
Sbjct: 182 DDWRKHDTSEINCPLFI-FSGQK 203
Score = 105 bits (263), Expect = 4e-22
Identities = 56/151 (37%), Positives = 88/151 (58%), Gaps = 3/151 (1%)
Query: 654 PCLRWLDKDKDDGQLVREL-LPSDSSATLKNFRYHISLKTGDVSGASTDSRVYIKLYGDK 712
P RWL +D++DG++ RE L S L Y +++ TG++ A T + VYI ++G+K
Sbjct: 10 PVQRWLARDQEDGEICREFPLLSKGQPVLPVTIYEVNVATGELWNAGTVANVYISIHGEK 69
Query: 713 SDTIKQVLLVSDNNLKDYFERGRVDEFTLETLNIGNINRLVIGHDSTGMHASWFLGSVQI 772
DT + L S ++ F RG+ D F LE +++G++ ++VIGHD G WFL V I
Sbjct: 70 GDTGSRQLFRSKSSFN--FLRGQTDTFFLEAVHLGDLCKIVIGHDGLGPGNGWFLDDVVI 127
Query: 773 RVPRQGKQYTFPANRWLDKNQADGRLEVELY 803
+ P +Y F +RWLD+ + D ++ ELY
Sbjct: 128 KDPTTNYEYAFFCHRWLDQGEDDCKIVRELY 158
Score = 99.0 bits (245), Expect = 5e-20
Identities = 57/170 (33%), Positives = 87/170 (51%), Gaps = 18/170 (10%)
Query: 1412 PCDRWLATSEDDKKTIRELVPYDIFTEKYMKDGSLRQVYKEVEEPLDIVLYSVQIFTGNI 1471
P RWLA ++D + RE + + + L + +Y V + TG +
Sbjct: 10 PVQRWLARDQEDGEICREF-----------------PLLSKGQPVLPVTIYEVNVATGEL 52
Query: 1472 PGAGTDAKVYITIYGDLGDTGERYLGKSENRTNKFERGTADTFIIEAADLGVIYKIKLRH 1531
AGT A VYI+I+G+ GDTG R L +S++ N F RG DTF +EA LG + KI + H
Sbjct: 53 WNAGTVANVYISIHGEKGDTGSRQLFRSKSSFN-FLRGQTDTFFLEAVHLGDLCKIVIGH 111
Query: 1532 DNSKWCADWYVEKVEIWNDTNEDEFLFLCGRWLSLKKEDGRLERLFYEKE 1581
D W+++ V I + T E+ F C RWL ++D ++ R Y ++
Sbjct: 112 DGLGPGNGWFLDDVVIKDPTTNYEYAFFCHRWLDQGEDDCKIVRELYARD 161
Score = 95.9 bits (237), Expect = 4e-19
Identities = 55/127 (43%), Positives = 75/127 (59%), Gaps = 2/127 (1%)
Query: 2084 SKVQSLVPVK-YEVIVTTGYEPGAGTDANVFVTIFGANGDTGKREL-KQKMRNLFERGST 2141
SK Q ++PV YEV V TG AGT ANV+++I G GDTG R+L + K F RG T
Sbjct: 32 SKGQPVLPVTIYEVNVATGELWNAGTVANVYISIHGEKGDTGSRQLFRSKSSFNFLRGQT 91
Query: 2142 DRFFLETLELGELRKVRLEHDSSGYCSGWLVEKVEVTNTSTGVATIFNCGRWLDKKRGDG 2201
D FFLE + LG+L K+ + HD G +GW ++ V + + +T F C RWLD+ D
Sbjct: 92 DTFFLEAVHLGDLCKIVIGHDGLGPGNGWFLDDVVIKDPTTNYEYAFFCHRWLDQGEDDC 151
Query: 2202 LTWRDLF 2208
R+L+
Sbjct: 152 KIVRELY 158
Score = 92.8 bits (229), Expect = 3e-18
Identities = 57/165 (34%), Positives = 85/165 (51%), Gaps = 1/165 (0%)
Query: 1783 MNTGDLTMFYYGDWLSQRKGKKTLVCEMCAVIDEEEMMEWTSYTVAVKTSDILGAGTDAN 1842
MN+G WL++ + + E + + ++ T Y V V T ++ AGT AN
Sbjct: 1 MNSGKQFYVPVQRWLARDQEDGEICREFPLLSKGQPVLPVTIYEVNVATGELWNAGTVAN 60
Query: 1843 VFIIIFGENGDSGTLALKQSANWNKFERNNTDTFNFPDMLSLGHLCKLRVWHDNKGIFPG 1902
V+I I GE GD+G+ L +S + F R TDTF F + + LG LCK+ + HD G G
Sbjct: 61 VYISIHGEKGDTGSRQLFRSKSSFNFLRGQTDTF-FLEAVHLGDLCKIVIGHDGLGPGNG 119
Query: 1903 WHLSYVDVKDNSRDETFHFQCDCWLSKSEGDGQTVRDFACANNKI 1947
W L V +KD + + + F C WL + E D + VR+ +N I
Sbjct: 120 WFLDDVVIKDPTTNYEYAFFCHRWLDQGEDDCKIVRELYARDNSI 164
Score = 90.5 bits (223), Expect = 2e-17
Identities = 64/227 (28%), Positives = 111/227 (48%), Gaps = 41/227 (18%)
Query: 422 LKKFPWSLWVWTTDLKKAGTNSPIFIQIYGQKGRTDEILLNPNN--KWFKPGIIEKFRIE 479
L + W + V T + GT + + + +YG KG T I L ++ + F PG ++F++
Sbjct: 535 LSEDEWKVLVLTGN---TGTQANVTLWVYGDKGVTGPISLRKDSSEQLFLPGHEDEFQV- 590
Query: 480 LPDLGRFYKIRVWHDKRSSGSGWHLERMTLMNTLNKDKYNFNCNRWLDANEDDNEIVREM 539
T+ + +K +F N WL + D ++V E+
Sbjct: 591 ----------------------------TMQHMKSKKILDFAANVWLSRIQADGDVVCEL 622
Query: 540 TAEGPTVR--RIMGMARYHVTVCTGELEGAGTDANVYLCLFGDVGDTGERLLYNCRNNTD 597
P V+ + + RY V V TG+L+ A T++ V+LCLFG+ GD+G R LY N
Sbjct: 623 ----PVVKGGQAIFPLRYQVDVYTGQLKHAETESEVFLCLFGERGDSGLRQLYK-SNMQV 677
Query: 598 LFEKGNADEFTIESVTMRNVRRVRIRHDGKGSGSGWYLDRVLVREEG 644
F++G D+F + +V++ +++V +R + WY ++V+VRE G
Sbjct: 678 KFQRGQIDKFQVAAVSLGKLQKVLLRCEASDKSQYWYCEQVIVREPG 724
Score = 90.1 bits (222), Expect = 2e-17
Identities = 53/126 (42%), Positives = 74/126 (58%), Gaps = 5/126 (3%)
Query: 778 GKQYTFPANRWLDKNQADGRLEVELYP--SEVVEIQKLVHYEVEIWTGDVGGAGTSARVY 835
GKQ+ P RWL ++Q DG + E +P S+ + + YEV + TG++ AGT A VY
Sbjct: 4 GKQFYVPVQRWLARDQEDGEICRE-FPLLSKGQPVLPVTIYEVNVATGELWNAGTVANVY 62
Query: 836 MQIYGEKGKT--EVLFLSSRSKVFERASKDTFQLEAADVGEVYKLRLGHTGEGFGPSWFV 893
+ I+GEKG T LF S S F R DTF LEA +G++ K+ +GH G G G WF+
Sbjct: 63 ISIHGEKGDTGSRQLFRSKSSFNFLRGQTDTFFLEAVHLGDLCKIVIGHDGLGPGNGWFL 122
Query: 894 DTVWLR 899
D V ++
Sbjct: 123 DDVVIK 128
Score = 88.6 bits (218), Expect = 6e-17
Identities = 59/181 (32%), Positives = 93/181 (51%), Gaps = 6/181 (3%)
Query: 386 TGIQQTFPCSNWLDEKKADGLIERQLYEMVSLRKKRLKKFPWSLWVWTTDLKKAGTNSPI 445
+G Q P WL + DG I R+ + ++S + L + + V T +L AGT + +
Sbjct: 3 SGKQFYVPVQRWLARDQEDGEICRE-FPLLSKGQPVLPVTIYEVNVATGELWNAGTVANV 61
Query: 446 FIQIYGQKGRTD--EILLNPNNKWFKPGIIEKFRIELPDLGRFYKIRVWHDKRSSGSGWH 503
+I I+G+KG T ++ + ++ F G + F +E LG KI + HD G+GW
Sbjct: 62 YISIHGEKGDTGSRQLFRSKSSFNFLRGQTDTFFLEAVHLGDLCKIVIGHDGLGPGNGWF 121
Query: 504 LERMTLMNTLNKDKYNFNCNRWLDANEDDNEIVREMTAEGPTVRRIMGMARYHVTVCTGE 563
L+ + + + +Y F C+RWLD EDD +IVRE+ A I +RYHV G+
Sbjct: 122 LDDVVIKDPTTNYEYAFFCHRWLDQGEDDCKIVRELYARD---NSIFSASRYHVYTFPGK 178
Query: 564 L 564
L
Sbjct: 179 L 179
Score = 84.0 bits (206), Expect = 2e-15
Identities = 68/214 (31%), Positives = 110/214 (51%), Gaps = 20/214 (9%)
Query: 950 DEGEEEESSSSEESSSEEEEMEEEEEEEEFGPGMQEVIEQH--KFEAHRWLARGKEDNEL 1007
D+G S ++SS E++ E+EF MQ + + F A+ WL+R + D ++
Sbjct: 562 DKGVTGPISLRKDSS---EQLFLPGHEDEFQVTMQHMKSKKILDFAANVWLSRIQADGDV 618
Query: 1008 VVELVPAGKPG----PERNTYEVQVVTGNVPKAGTDANVYLTIYGEEYGDTGERPLKKSD 1063
V EL P K G P R Y+V V TG + A T++ V+L ++GE GD+G R L KS+
Sbjct: 619 VCEL-PVVKGGQAIFPLR--YQVDVYTGQLKHAETESEVFLCLFGER-GDSGLRQLYKSN 674
Query: 1064 KSNKFEQGQTDTFTIYAIDLGALTKIRIRHDNTGNRAGWFLDRIDITDMNNEITYYFPCQ 1123
KF++GQ D F + A+ LG L K+ +R + + W+ +++ + + F CQ
Sbjct: 675 MQVKFQRGQIDKFQVAAVSLGKLQKVLLRCEASDKSQYWYCEQVIVREPGTTSESIFTCQ 734
Query: 1124 RWLAVEEDDGQLSRELLPVDE----SYVLPQSEE 1153
++ + Q S +L DE S +L +EE
Sbjct: 735 ---SLPAHNFQASPSMLYRDETVPTSLILKGAEE 765
Score = 83.2 bits (204), Expect = 3e-15
Identities = 54/165 (32%), Positives = 84/165 (50%), Gaps = 13/165 (7%)
Query: 27 ASEDDEGELEHEY---------YKARVYEVVTATGDVRGAGTDANVFITLFGENGLSPKL 77
A + ++GE+ E+ +YEV ATG++ AGT ANV+I++ GE G +
Sbjct: 16 ARDQEDGEICREFPLLSKGQPVLPVTIYEVNVATGELWNAGTVANVYISIHGEKGDTGSR 75
Query: 78 QL-TSKSKSAFEKGNVDVFRVRTNNVGLIYKVRIEHDNTGLNASWYLDHVIVTDMKRPHL 136
QL SKS F +G D F + ++G + K+ I HD G W+LD V++ D +
Sbjct: 76 QLFRSKSSFNFLRGQTDTFFLEAVHLGDLCKIVIGHDGLGPGNGWFLDDVVIKD-PTTNY 134
Query: 137 RYYFNCNNWLSKVEGDRQWCRDLLASFNPMDMPRGNKYEVKVYTG 181
Y F C+ WL + E D + R+L A N + ++Y V + G
Sbjct: 135 EYAFFCHRWLDQGEDDCKIVRELYARDN--SIFSASRYHVYTFPG 177
Score = 79.3 bits (194), Expect = 4e-14
Identities = 58/221 (26%), Positives = 106/221 (47%), Gaps = 37/221 (16%)
Query: 555 YHVTVCTGELEGAGTDANVYLCLFGDVGDTGERLLYNCRNNTDLFEKGNADEFTIESVTM 614
+ V V TG GT ANV L ++GD G TG L ++ LF G+ DEF VTM
Sbjct: 540 WKVLVLTGN---TGTQANVTLWVYGDKGVTGPISLRK-DSSEQLFLPGHEDEF---QVTM 592
Query: 615 RNVRRVRIRHDGKGSGSGWYLDRVLVREEGQPESDNVEFPCLRWLDKDKDDGQLVRELLP 674
++++ +I ++F WL + + DG +V EL
Sbjct: 593 QHMKSKKI----------------------------LDFAANVWLSRIQADGDVVCELPV 624
Query: 675 SDSSATLKNFRYHISLKTGDVSGASTDSRVYIKLYGDKSDTIKQVLLVSDNNLKDYFERG 734
+ RY + + TG + A T+S V++ L+G++ D+ + L S+ +K F+RG
Sbjct: 625 VKGGQAIFPLRYQVDVYTGQLKHAETESEVFLCLFGERGDSGLRQLYKSNMQVK--FQRG 682
Query: 735 RVDEFTLETLNIGNINRLVIGHDSTGMHASWFLGSVQIRVP 775
++D+F + +++G + ++++ +++ W+ V +R P
Sbjct: 683 QIDKFQVAAVSLGKLQKVLLRCEASDKSQYWYCEQVIVREP 723
Score = 79.0 bits (193), Expect = 5e-14
Identities = 59/231 (25%), Positives = 110/231 (47%), Gaps = 39/231 (16%)
Query: 172 NKYEVKVYTGDVIGAGTDADVFINIFGEYGDTG--ERRLENEKDNFEKGAEDRFILDAPD 229
++++V V TG+ GT A+V + ++G+ G TG R ++ + F G ED F
Sbjct: 538 DEWKVLVLTGNT---GTQANVTLWVYGDKGVTGPISLRKDSSEQLFLPGHEDEF------ 588
Query: 230 LGQLMKINVGHNNKGGSAGWFLSQIVIEDIGNKRKYDFPLNRWLALDEDDGKI--QRDIL 287
Q+ ++ + +K+ DF N WL+ + DG + + ++
Sbjct: 589 -----------------------QVTMQHMKSKKILDFAANVWLSRIQADGDVVCELPVV 625
Query: 288 VGGAETTAITYIVTVFTGDVRGAGTKSKIYLVMYGARGNKNSGKIFLEG--GVFDRGRTD 345
GG + Y V V+TG ++ A T+S+++L ++G RG+ +++ F RG+ D
Sbjct: 626 KGGQAIFPLRYQVDVYTGQLKHAETESEVFLCLFGERGDSGLRQLYKSNMQVKFQRGQID 685
Query: 346 IFHIELAVLLSPLSRVSVGHGNVGVNRGWFCEKVVILCPFTGIQQTFPCSN 396
F + AV L L +V + ++ W+CE+V++ P T + F C +
Sbjct: 686 KFQV-AAVSLGKLQKVLLRCEASDKSQYWYCEQVIVREPGTTSESIFTCQS 735
Score = 77.4 bits (189), Expect = 1e-13
Identities = 56/167 (33%), Positives = 81/167 (48%), Gaps = 9/167 (5%)
Query: 1268 GKCMTFPCGRWLAKNEDDGSIIRDLFHAELQTRLYTPFVPYEITLYTSDVFAAGTDANIF 1327
GK P RWLA++++DG I R+ F + + P YE+ + T +++ AGT AN++
Sbjct: 4 GKQFYVPVQRWLARDQEDGEICRE-FPLLSKGQPVLPVTIYEVNVATGELWNAGTVANVY 62
Query: 1328 IIIYGCDAVCTQQKYLCTNKREQKQFFERKSASRFIVELEDVGEIIEKIRIGHNNTGMNP 1387
I I+G + T + L +K F R F +E +G++ KI IGH+ G
Sbjct: 63 ISIHG-EKGDTGSRQLFRSKSSFN--FLRGQTDTFFLEAVHLGDLC-KIVIGHDGLGPGN 118
Query: 1388 GWHCSHVDIRRLLPDKDGAETLTFPCDRWLATSEDDKKTIRELVPYD 1434
GW V I+ D F C RWL EDD K +REL D
Sbjct: 119 GWFLDDVVIK----DPTTNYEYAFFCHRWLDQGEDDCKIVRELYARD 161
Score = 75.1 bits (183), Expect = 7e-13
Identities = 89/394 (22%), Positives = 160/394 (40%), Gaps = 54/394 (13%)
Query: 670 RELLPSDSSATLKNFRYHISLKTGD-------VSGASTDSRVYIKLYGDKSDTIKQVLLV 722
R LPS ++ +++F+ +L + D T + V + +YGDK T + L
Sbjct: 514 RSPLPSSTAKEIRHFQSSETLLSEDEWKVLVLTGNTGTQANVTLWVYGDKGVT-GPISLR 572
Query: 723 SDNNLKDYFERGRVDEFTLETLNIGNINRLVIGHDSTGMHASWFLGSVQIRVPRQGKQYT 782
D++ + F G DEF V ++ + K
Sbjct: 573 KDSS-EQLFLPGHEDEF-----------------------------QVTMQHMKSKKILD 602
Query: 783 FPANRWLDKNQADGRLEVELYPSEVVEIQKLVHYEVEIWTGDVGGAGTSARVYMQIYGEK 842
F AN WL + QADG + EL + + + Y+V+++TG + A T + V++ ++GE+
Sbjct: 603 FAANVWLSRIQADGDVVCELPVVKGGQAIFPLRYQVDVYTGQLKHAETESEVFLCLFGER 662
Query: 843 GKTEV--LFLSSRSKVFERASKDTFQLEAADVGEVYKLRLGHTGEGFGPSWFVDTVWLRH 900
G + + L+ S+ F+R D FQ+ A +G++ K+ L W+ + V
Sbjct: 663 GDSGLRQLYKSNMQVKFQRGQIDKFQVAAVSLGKLQKVLLRCEASDKSQYWYCEQV---- 718
Query: 901 LVVREVDLTPE-----EEARKKKEKDKLRQLLKKERLKAKLQRKKKKRKGSDEEDEGEEE 955
+VRE T E + + L + E + L K + G+ G
Sbjct: 719 -IVREPGTTSESIFTCQSLPAHNFQASPSMLYRDETVPTSLILKGAEEYGTRNRTWG--T 775
Query: 956 ESSSSEESSSEEEEMEEEEEEEEFGPGMQEVIEQHKFEAHRWLARGKEDNELVVELVPAG 1015
S + + + + + + + H A + + + KE + EL
Sbjct: 776 AGSFLLQKKAILKPLIVTSVSQSLFCAYEVKVSVH--GAWKAVLKRKESHGCTQELEWTV 833
Query: 1016 KPGPERNTYEVQVVTGNVPKAGTDANVYLTIYGE 1049
G ++V +VTG++ AGT A V+L +YGE
Sbjct: 834 LAGELDGDWKVTIVTGDLENAGTTATVFLYVYGE 867
Score = 74.3 bits (181), Expect = 1e-12
Identities = 83/331 (25%), Positives = 129/331 (38%), Gaps = 70/331 (21%)
Query: 952 GEEEESSSSEESSSEEEEMEEEEEEEEFGPGMQEVIEQHKFEAHRWLARGKEDNELVVEL 1011
G E S S EEE++ E +++++ P + A R + +E ++
Sbjct: 480 GRENPMGMSATPSQEEEKIHESKKQKKIPPESEARSPLPSSTAKE--IRHFQSSETLLS- 536
Query: 1012 VPAGKPGPERNTYEVQVVTGNVPKAGTDANVYLTIYGEEYGDTGERPLKKSDKSNKFEQG 1071
+ ++V V+TGN GT ANV L +YG++ G TG L+K F G
Sbjct: 537 ---------EDEWKVLVLTGNT---GTQANVTLWVYGDK-GVTGPISLRKDSSEQLFLPG 583
Query: 1072 QTDTFTIYAIDLGALTKIRIRHDNTGNRAGWFLDRIDITDMNNEITYYFPCQRWLAVEED 1131
D F ++ + M ++ F WL+ +
Sbjct: 584 HEDEF-----------------------------QVTMQHMKSKKILDFAANVWLSRIQA 614
Query: 1132 DGQLSRELLPVDESYVLPQSEEGRGGGDNNPLDNLALEQKDKSTTFSVTIKTGVKKNAGT 1191
DG + EL V +GG PL + V + TG K+A T
Sbjct: 615 DGDVVCELPVV------------KGGQAIFPL------------RYQVDVYTGQLKHAET 650
Query: 1192 DANVFITLFGTQDDTGMTLLKSSKTNSDKFERDSIEIFTVETLDLGDLWKVRLGHDNTGK 1251
++ VF+ LFG + D+G+ L S KF+R I+ F V + LG L KV L + + K
Sbjct: 651 ESEVFLCLFGERGDSGLRQLYKSNMQV-KFQRGQIDKFQVAAVSLGKLQKVLLRCEASDK 709
Query: 1252 APGWFVDWVEVDAPSLGKCMTFPCGRWLAKN 1282
+ W+ + V V P F C A N
Sbjct: 710 SQYWYCEQVIVREPGTTSESIFTCQSLPAHN 740
Score = 74.3 bits (181), Expect = 1e-12
Identities = 59/220 (26%), Positives = 104/220 (47%), Gaps = 39/220 (17%)
Query: 45 YEVVTATGDVRGAGTDANVFITLFGENGLSPKLQLTS-KSKSAFEKGNVDVFRVRTNNVG 103
++V+ TG+ GT ANV + ++G+ G++ + L S+ F G+ D F+V +
Sbjct: 540 WKVLVLTGNT---GTQANVTLWVYGDKGVTGPISLRKDSSEQLFLPGHEDEFQVTMQH-- 594
Query: 104 LIYKVRIEHDNTGLNASWYLDHVIVTDMKRPHLRYYFNCNNWLSKVEGDRQWCRDL-LAS 162
+ + LD F N WLS+++ D +L +
Sbjct: 595 -------------MKSKKILD---------------FAANVWLSRIQADGDVVCELPVVK 626
Query: 163 FNPMDMPRGNKYEVKVYTGDVIGAGTDADVFINIFGEYGDTGERRL--ENEKDNFEKGAE 220
P +Y+V VYTG + A T+++VF+ +FGE GD+G R+L N + F++G
Sbjct: 627 GGQAIFPL--RYQVDVYTGQLKHAETESEVFLCLFGERGDSGLRQLYKSNMQVKFQRGQI 684
Query: 221 DRFILDAPDLGQLMKINVGHNNKGGSAGWFLSQIVIEDIG 260
D+F + A LG+L K+ + S W+ Q+++ + G
Sbjct: 685 DKFQVAAVSLGKLQKVLLRCEASDKSQYWYCEQVIVREPG 724
Score = 73.9 bits (180), Expect = 2e-12
Identities = 40/105 (38%), Positives = 62/105 (59%), Gaps = 1/105 (0%)
Query: 2087 QSLVPVKYEVIVTTGYEPGAGTDANVFVTIFGANGDTGKREL-KQKMRNLFERGSTDRFF 2145
Q++ P++Y+V V TG A T++ VF+ +FG GD+G R+L K M+ F+RG D+F
Sbjct: 629 QAIFPLRYQVDVYTGQLKHAETESEVFLCLFGERGDSGLRQLYKSNMQVKFQRGQIDKFQ 688
Query: 2146 LETLELGELRKVRLEHDSSGYCSGWLVEKVEVTNTSTGVATIFNC 2190
+ + LG+L+KV L ++S W E+V V T +IF C
Sbjct: 689 VAAVSLGKLQKVLLRCEASDKSQYWYCEQVIVREPGTTSESIFTC 733
Score = 71.6 bits (174), Expect = 8e-12
Identities = 39/118 (33%), Positives = 65/118 (55%), Gaps = 2/118 (1%)
Query: 1697 LYEMTVWTGDVVGGGTDSNIFMTLYGINGSTEEMQLDKKKARFE--REQNDTFIMEILDI 1754
+YE+ V TG++ GT +N++++++G G T QL + K+ F R Q DTF +E + +
Sbjct: 42 IYEVNVATGELWNAGTVANVYISIHGEKGDTGSRQLFRSKSSFNFLRGQTDTFFLEAVHL 101
Query: 1755 APFTKMRIRIDGLGSRPEWFLERILLKNMNTGDLTMFYYGDWLSQRKGKKTLVCEMCA 1812
K+ I DGLG WFL+ +++K+ T F+ WL Q + +V E+ A
Sbjct: 102 GDLCKIVIGHDGLGPGNGWFLDDVVIKDPTTNYEYAFFCHRWLDQGEDDCKIVRELYA 159
Score = 68.9 bits (167), Expect = 5e-11
Identities = 36/99 (36%), Positives = 56/99 (56%), Gaps = 1/99 (1%)
Query: 1462 YSVQIFTGNIPGAGTDAKVYITIYGDLGDTGERYLGKSENRTNKFERGTADTFIIEAADL 1521
Y V ++TG + A T+++V++ ++G+ GD+G R L KS N KF+RG D F + A L
Sbjct: 636 YQVDVYTGQLKHAETESEVFLCLFGERGDSGLRQLYKS-NMQVKFQRGQIDKFQVAAVSL 694
Query: 1522 GVIYKIKLRHDNSKWCADWYVEKVEIWNDTNEDEFLFLC 1560
G + K+ LR + S WY E+V + E +F C
Sbjct: 695 GKLQKVLLRCEASDKSQYWYCEQVIVREPGTTSESIFTC 733
Score = 58.2 bits (139), Expect = 9e-08
Identities = 56/228 (24%), Positives = 93/228 (40%), Gaps = 36/228 (15%)
Query: 1698 YEMTVWTGDVVGGGTDSNIFMTLYGINGSTEEMQL--DKKKARFEREQNDTFIMEILDIA 1755
+++ V TG+ GT +N+ + +YG G T + L D + F D F
Sbjct: 540 WKVLVLTGNT---GTQANVTLWVYGDKGVTGPISLRKDSSEQLFLPGHEDEF-------- 588
Query: 1756 PFTKMRIRIDGLGSRPEWFLERILLKNMNTGDLTMFYYGDWLSQRKGKKTLVCEMCAVID 1815
++ +++M + + F WLS+ + +VCE+ V
Sbjct: 589 ---------------------QVTMQHMKSKKILDFAANVWLSRIQADGDVVCELPVVKG 627
Query: 1816 EEEMMEWTSYTVAVKTSDILGAGTDANVFIIIFGENGDSGTLALKQSANWNKFERNNTDT 1875
+ + Y V V T + A T++ VF+ +FGE GDSG L +S KF+R D
Sbjct: 628 GQAIFP-LRYQVDVYTGQLKHAETESEVFLCLFGERGDSGLRQLYKSNMQVKFQRGQIDK 686
Query: 1876 FNFPDMLSLGHLCKLRVWHDNKGIFPGWHLSYVDVKDNSRDETFHFQC 1923
F +SLG L K+ + + W+ V V++ F C
Sbjct: 687 FQVA-AVSLGKLQKVLLRCEASDKSQYWYCEQVIVREPGTTSESIFTC 733
Score = 57.4 bits (137), Expect = 2e-07
Identities = 98/443 (22%), Positives = 163/443 (36%), Gaps = 118/443 (26%)
Query: 1462 YSVQIFTGNIPGAGTDAKVYITIYGDLGDTGERYLGKSENRTNKFERGTADTFIIEAADL 1521
+ V + TGN GT A V + +YGD G TG L K + F G D F
Sbjct: 540 WKVLVLTGN---TGTQANVTLWVYGDKGVTGPISLRKDSSE-QLFLPGHEDEF------- 588
Query: 1522 GVIYKIKLRHDNSKWCADWYVEKVEIWNDTNEDEFLFLCGRWLSLKKEDGRLERLFYEKE 1581
++ ++H SK D F WLS + DG +
Sbjct: 589 ----QVTMQHMKSKKILD------------------FAANVWLSRIQADGDVV------- 619
Query: 1582 YTGDRSSNCSSPADFWEIALSSKMADVDISTVTGPMADYVQEGPIIPYYVSVTTGKHKDA 1641
C P V G A + + Y V V TG+ K A
Sbjct: 620 --------CELPV------------------VKGGQAIFP-----LRYQVDVYTGQLKHA 648
Query: 1642 ATDSRAFIFLIGE-DDERSKRIWLDYPRGKRGFSRGSVEEFYVAGLDVGIIKKI----EV 1696
T+S F+ L GE D ++++ + K F RG +++F VA + +G ++K+ E
Sbjct: 649 ETESEVFLCLFGERGDSGLRQLYKSNMQVK--FQRGQIDKFQVAAVSLGKLQKVLLRCEA 706
Query: 1697 LYEMTVWTGDVV----GGGTDSNIFMTLYGINGSTEEMQLDKKKARFEREQNDTFIMEIL 1752
+ W + V G T +IF + + + +A D + L
Sbjct: 707 SDKSQYWYCEQVIVREPGTTSESIF--------TCQSLPAHNFQASPSMLYRDETVPTSL 758
Query: 1753 DIAPFTKMRIRIDGLGSRPEWFLER------ILLKNMNTG-----DLTMFYYGDWLSQRK 1801
+ + R G+ + L++ +++ +++ ++ + +G W + K
Sbjct: 759 ILKGAEEYGTRNRTWGTAGSFLLQKKAILKPLIVTSVSQSLFCAYEVKVSVHGAWKAVLK 818
Query: 1802 GKKTLVCEMCAVIDEEEMMEWT--------SYTVAVKTSDILGAGTDANVFIIIFGENGD 1853
K++ C + +EWT + V + T D+ AGT A VF+ ++GE
Sbjct: 819 RKESHGC--------TQELEWTVLAGELDGDWKVTIVTGDLENAGTTATVFLYVYGETKC 870
Query: 1854 SGTLALKQSANWNKFERNNTDTF 1876
SG + L S F N D F
Sbjct: 871 SGPIIL-GSGKHQLFNPNTADIF 892
Score = 55.8 bits (133), Expect = 4e-07
Identities = 40/142 (28%), Positives = 65/142 (45%), Gaps = 11/142 (7%)
Query: 1919 FHFQCDCWLSKSEGDGQTVRDFACANNKICDELEETTYEIVIETG---NGGETRENVWLI 1975
F+ WL++ + DG+ R+F + K L T YE+ + TG N G T NV++
Sbjct: 7 FYVPVQRWLARDQEDGEICREFPLLS-KGQPVLPVTIYEVNVATGELWNAG-TVANVYIS 64
Query: 1976 LEGRKNRSKEFLMENSSRQRAFRKGTTDTFEFDSIYLGDIASLCVGHLAREDRFIPKREL 2035
+ G K + + S F +G TDTF ++++LGD+ + +GH D P
Sbjct: 65 IHGEKGDTGSRQLFRSKSSFNFLRGQTDTFFLEAVHLGDLCKIVIGH----DGLGPGN-- 118
Query: 2036 AWHVKTITITEMEYGNVYFFNC 2057
W + + I + Y F C
Sbjct: 119 GWFLDDVVIKDPTTNYEYAFFC 140
Score = 49.3 bits (116), Expect = 4e-05
Identities = 49/246 (19%), Positives = 98/246 (39%), Gaps = 43/246 (17%)
Query: 1817 EEMMEWTSYTVAVKTSDILGAGTDANVFIIIFGENGDSGTLALKQSANWNKFERNNTDTF 1876
E ++ + V V T + GT ANV + ++G+ G +G ++L++ ++ F + D F
Sbjct: 532 ETLLSEDEWKVLVLTGN---TGTQANVTLWVYGDKGVTGPISLRKDSSEQLFLPGHEDEF 588
Query: 1877 NFPDMLSLGHLCKLRVWHDNKGIFPGWHLSYVDVKDNSRDETFHFQCDCWLSKSEGDGQT 1936
+++ H+ ++ F + WLS+ + DG
Sbjct: 589 Q----VTMQHMKSKKI--------------------------LDFAANVWLSRIQADGDV 618
Query: 1937 VRDFACANNKICDELEETTYEIVIETG--NGGETRENVWLILEGRKNRSKEFLMENSSRQ 1994
V + K + Y++ + TG ET V+L L G + S + S+ Q
Sbjct: 619 VCELPVV--KGGQAIFPLRYQVDVYTGQLKHAETESEVFLCLFGERGDSGLRQLYKSNMQ 676
Query: 1995 RAFRKGTTDTFEFDSIYLGDIASLCVGHLAREDRFIPKRELAWHVKTITITEMEYGNVYF 2054
F++G D F+ ++ LG + + + A + + W+ + + + E +
Sbjct: 677 VKFQRGQIDKFQVAAVSLGKLQKVLLRCEASD------KSQYWYCEQVIVREPGTTSESI 730
Query: 2055 FNCDCL 2060
F C L
Sbjct: 731 FTCQSL 736
Score = 44.3 bits (103), Expect = 0.001
Identities = 34/135 (25%), Positives = 63/135 (46%), Gaps = 8/135 (5%)
Query: 392 FPCSNWLDEKKADGLIERQLYEMVSLRKKRLKKFP--WSLWVWTTDLKKAGTNSPIFIQI 449
F + WL +ADG + +L + K FP + + V+T LK A T S +F+ +
Sbjct: 603 FAANVWLSRIQADGDVVCEL----PVVKGGQAIFPLRYQVDVYTGQLKHAETESEVFLCL 658
Query: 450 YGQKGRTDEILLNPNNKW--FKPGIIEKFRIELPDLGRFYKIRVWHDKRSSGSGWHLERM 507
+G++G + L +N F+ G I+KF++ LG+ K+ + + W+ E++
Sbjct: 659 FGERGDSGLRQLYKSNMQVKFQRGQIDKFQVAAVSLGKLQKVLLRCEASDKSQYWYCEQV 718
Query: 508 TLMNTLNKDKYNFNC 522
+ + F C
Sbjct: 719 IVREPGTTSESIFTC 733
Score = 40.8 bits (94), Expect = 0.015
Identities = 44/221 (19%), Positives = 95/221 (42%), Gaps = 39/221 (17%)
Query: 1177 FSVTIKTGVKKNAGTDANVFITLFGTQDDTGMTLLKSSKTNSDKFERDSIEIFTVETLDL 1236
+ V + TG N GT ANV + ++G + TG L+ +DS E +
Sbjct: 540 WKVLVLTG---NTGTQANVTLWVYGDKGVTGPISLR----------KDSSEQLFLP---- 582
Query: 1237 GDLWKVRLGHDNTGKAPGWFVDWVEVDAPSLGKCMTFPCGRWLAKNEDDGSIIRDLFHAE 1296
GH++ + V + K + F WL++ + DG ++ +L +
Sbjct: 583 --------GHEDEFQ--------VTMQHMKSKKILDFAANVWLSRIQADGDVVCELPVVK 626
Query: 1297 LQTRLYTPFVPYEITLYTSDVFAAGTDANIFIIIYGCDAVCTQQKYLCTNKREQKQFFER 1356
++ + Y++ +YT + A T++ +F+ ++G ++ +N + + F+R
Sbjct: 627 GGQAIFP--LRYQVDVYTGQLKHAETESEVFLCLFGERGDSGLRQLYKSNMQVK---FQR 681
Query: 1357 KSASRFIVELEDVGEIIEKIRIGHNNTGMNPGWHCSHVDIR 1397
+F V +G+ ++K+ + + + W+C V +R
Sbjct: 682 GQIDKFQVAAVSLGK-LQKVLLRCEASDKSQYWYCEQVIVR 721
Score = 38.5 bits (88), Expect = 0.074
Identities = 18/52 (34%), Positives = 27/52 (51%)
Query: 45 YEVVTATGDVRGAGTDANVFITLFGENGLSPKLQLTSKSKSAFEKGNVDVFR 96
++V TGD+ AGT A VF+ ++GE S + L S F D+F+
Sbjct: 842 WKVTIVTGDLENAGTTATVFLYVYGETKCSGPIILGSGKHQLFNPNTADIFK 893
Score = 36.2 bits (82), Expect = 0.37
Identities = 21/51 (41%), Positives = 29/51 (56%), Gaps = 5/51 (9%)
Query: 300 VTVFTGDVRGAGTKSKIYLVMYGARGNKNSGKIFLEGG---VFDRGRTDIF 347
VT+ TGD+ AGT + ++L +YG K SG I L G +F+ DIF
Sbjct: 844 VTIVTGDLENAGTTATVFLYVYGE--TKCSGPIILGSGKHQLFNPNTADIF 892
Score = 35.4 bits (80), Expect = 0.63
Identities = 18/52 (34%), Positives = 32/52 (61%), Gaps = 1/52 (1%)
Query: 816 YEVEIWTGDVGGAGTSARVYMQIYGE-KGKTEVLFLSSRSKVFERASKDTFQ 866
++V I TGD+ AGT+A V++ +YGE K ++ S + ++F + D F+
Sbjct: 842 WKVTIVTGDLENAGTTATVFLYVYGETKCSGPIILGSGKHQLFNPNTADIFK 893
Score = 33.5 bits (75), Expect = 2.4
Identities = 20/53 (37%), Positives = 30/53 (56%), Gaps = 2/53 (3%)
Query: 1177 FSVTIKTGVKKNAGTDANVFITLFGTQDDTGMTLLKSSKTNSDKFERDSIEIF 1229
+ VTI TG +NAGT A VF+ ++G +G +L S K F ++ +IF
Sbjct: 842 WKVTIVTGDLENAGTTATVFLYVYGETKCSGPIILGSGK--HQLFNPNTADIF 892
Score = 32.7 bits (73), Expect = 4.1
Identities = 24/69 (34%), Positives = 31/69 (44%), Gaps = 4/69 (5%)
Query: 2077 KTTESFASKVQSLVPVKYEVIVTTGYEPGAGTDANVFVTIFGANGDTGKREL-KQKMRNL 2135
K F S L +++V+V TG GT ANV + ++G G TG L K L
Sbjct: 523 KEIRHFQSSETLLSEDEWKVLVLTG---NTGTQANVTLWVYGDKGVTGPISLRKDSSEQL 579
Query: 2136 FERGSTDRF 2144
F G D F
Sbjct: 580 FLPGHEDEF 588
>gi|239743562 PREDICTED: hypothetical protein XP_002342894 [Homo
sapiens]
Length = 1029
Score = 127 bits (319), Expect = 1e-28
Identities = 75/160 (46%), Positives = 92/160 (57%), Gaps = 3/160 (1%)
Query: 988 EQHKFEAHRWLARGKEDNELVVE--LVPAGKPGPERNTYEVQVVTGNVPKAGTDANVYLT 1045
+Q RWLAR +ED E+ E L+ G+P YEV V TG + AGT ANVY++
Sbjct: 5 KQFYVPVQRWLARDQEDGEICREFPLLSKGQPVLPVTIYEVNVATGELWNAGTVANVYIS 64
Query: 1046 IYGEEYGDTGERPLKKSDKSNKFEQGQTDTFTIYAIDLGALTKIRIRHDNTGNRAGWFLD 1105
I+GE+ GDTG R L +S S F +GQTDTF + A+ LG L KI I HD G GWFLD
Sbjct: 65 IHGEK-GDTGSRQLFRSKSSFNFLRGQTDTFFLEAVHLGDLCKIVIGHDGLGPGNGWFLD 123
Query: 1106 RIDITDMNNEITYYFPCQRWLAVEEDDGQLSRELLPVDES 1145
+ I D Y F C RWL EDD ++ REL D S
Sbjct: 124 DVVIKDPTTNYEYAFFCHRWLDQGEDDCKIVRELYARDNS 163
Score = 115 bits (287), Expect = 6e-25
Identities = 67/169 (39%), Positives = 104/169 (61%), Gaps = 13/169 (7%)
Query: 524 RWLDANEDDNEIVRE--MTAEGPTVRRIMGMARYHVTVCTGELEGAGTDANVYLCLFGDV 581
RWL +++D EI RE + ++G V + + Y V V TGEL AGT ANVY+ + G+
Sbjct: 13 RWLARDQEDGEICREFPLLSKGQPV---LPVTIYEVNVATGELWNAGTVANVYISIHGEK 69
Query: 582 GDTGERLLYNCRNNTDLFEKGNADEFTIESVTMRNVRRVRIRHDGKGSGSGWYLDRVLVR 641
GDTG R L+ +++ + F +G D F +E+V + ++ ++ I HDG G G+GW+LD V+++
Sbjct: 70 GDTGSRQLFRSKSSFN-FLRGQTDTFFLEAVHLGDLCKIVIGHDGLGPGNGWFLDDVVIK 128
Query: 642 EEGQPESDNVE--FPCLRWLDKDKDDGQLVRELLPSDSSATLKNFRYHI 688
+ + N E F C RWLD+ +DD ++VREL D+S RYH+
Sbjct: 129 D----PTTNYEYAFFCHRWLDQGEDDCKIVRELYARDNS-IFSASRYHV 172
Score = 110 bits (275), Expect = 2e-23
Identities = 70/174 (40%), Positives = 98/174 (56%), Gaps = 7/174 (4%)
Query: 137 RYYFNCNNWLSKVEGDRQWCRD--LLASFNPMDMPRGNKYEVKVYTGDVIGAGTDADVFI 194
++Y WL++ + D + CR+ LL+ P+ +P YEV V TG++ AGT A+V+I
Sbjct: 6 QFYVPVQRWLARDQEDGEICREFPLLSKGQPV-LPV-TIYEVNVATGELWNAGTVANVYI 63
Query: 195 NIFGEYGDTGERRLENEKD--NFEKGAEDRFILDAPDLGQLMKINVGHNNKGGSAGWFLS 252
+I GE GDTG R+L K NF +G D F L+A LG L KI +GH+ G GWFL
Sbjct: 64 SIHGEKGDTGSRQLFRSKSSFNFLRGQTDTFFLEAVHLGDLCKIVIGHDGLGPGNGWFLD 123
Query: 253 QIVIEDIGNKRKYDFPLNRWLALDEDDGKIQRDILV-GGAETTAITYIVTVFTG 305
+VI+D +Y F +RWL EDD KI R++ + +A Y V F G
Sbjct: 124 DVVIKDPTTNYEYAFFCHRWLDQGEDDCKIVRELYARDNSIFSASRYHVYTFPG 177
Score = 108 bits (269), Expect = 8e-23
Identities = 66/183 (36%), Positives = 94/183 (51%), Gaps = 26/183 (14%)
Query: 1112 MNNEITYYFPCQRWLAVEEDDGQLSRELLPVDESY-VLPQSEEGRGGGDNNPLDNLALEQ 1170
MN+ +Y P QRWLA +++DG++ RE + + VLP
Sbjct: 1 MNSGKQFYVPVQRWLARDQEDGEICREFPLLSKGQPVLP--------------------- 39
Query: 1171 KDKSTTFSVTIKTGVKKNAGTDANVFITLFGTQDDTGMTLLKSSKTNSDKFERDSIEIFT 1230
T + V + TG NAGT ANV+I++ G + DTG L SK +S F R + F
Sbjct: 40 ---VTIYEVNVATGELWNAGTVANVYISIHGEKGDTGSRQLFRSK-SSFNFLRGQTDTFF 95
Query: 1231 VETLDLGDLWKVRLGHDNTGKAPGWFVDWVEVDAPSLGKCMTFPCGRWLAKNEDDGSIIR 1290
+E + LGDL K+ +GHD G GWF+D V + P+ F C RWL + EDD I+R
Sbjct: 96 LEAVHLGDLCKIVIGHDGLGPGNGWFLDDVVIKDPTTNYEYAFFCHRWLDQGEDDCKIVR 155
Query: 1291 DLF 1293
+L+
Sbjct: 156 ELY 158
Score = 108 bits (269), Expect = 8e-23
Identities = 72/203 (35%), Positives = 111/203 (54%), Gaps = 16/203 (7%)
Query: 263 RKYDFPLNRWLALDEDDGKIQRD--ILVGGAETTAIT-YIVTVFTGDVRGAGTKSKIYLV 319
+++ P+ RWLA D++DG+I R+ +L G +T Y V V TG++ AGT + +Y+
Sbjct: 5 KQFYVPVQRWLARDQEDGEICREFPLLSKGQPVLPVTIYEVNVATGELWNAGTVANVYIS 64
Query: 320 MYGARGNKNSGKIFLEGGVFD--RGRTDIFHIELAVLLSPLSRVSVGHGNVGVNRGWFCE 377
++G +G+ S ++F F+ RG+TD F +E AV L L ++ +GH +G GWF +
Sbjct: 65 IHGEKGDTGSRQLFRSKSSFNFLRGQTDTFFLE-AVHLGDLCKIVIGHDGLGPGNGWFLD 123
Query: 378 KVVILCPFTGIQQTFPCSNWLDEKKADGLIERQLY----EMVSLRKKRLKKFPWSLWVWT 433
VVI P T + F C WLD+ + D I R+LY + S + + FP L+
Sbjct: 124 DVVIKDPTTNYEYAFFCHRWLDQGEDDCKIVRELYARDNSIFSASRYHVYTFPGKLFY-- 181
Query: 434 TDLKKAGT---NSPIFIQIYGQK 453
D +K T N P+FI GQK
Sbjct: 182 DDWRKHDTSEINCPLFI-FSGQK 203
Score = 105 bits (263), Expect = 4e-22
Identities = 56/151 (37%), Positives = 88/151 (58%), Gaps = 3/151 (1%)
Query: 654 PCLRWLDKDKDDGQLVREL-LPSDSSATLKNFRYHISLKTGDVSGASTDSRVYIKLYGDK 712
P RWL +D++DG++ RE L S L Y +++ TG++ A T + VYI ++G+K
Sbjct: 10 PVQRWLARDQEDGEICREFPLLSKGQPVLPVTIYEVNVATGELWNAGTVANVYISIHGEK 69
Query: 713 SDTIKQVLLVSDNNLKDYFERGRVDEFTLETLNIGNINRLVIGHDSTGMHASWFLGSVQI 772
DT + L S ++ F RG+ D F LE +++G++ ++VIGHD G WFL V I
Sbjct: 70 GDTGSRQLFRSKSSFN--FLRGQTDTFFLEAVHLGDLCKIVIGHDGLGPGNGWFLDDVVI 127
Query: 773 RVPRQGKQYTFPANRWLDKNQADGRLEVELY 803
+ P +Y F +RWLD+ + D ++ ELY
Sbjct: 128 KDPTTNYEYAFFCHRWLDQGEDDCKIVRELY 158
Score = 99.0 bits (245), Expect = 5e-20
Identities = 57/170 (33%), Positives = 87/170 (51%), Gaps = 18/170 (10%)
Query: 1412 PCDRWLATSEDDKKTIRELVPYDIFTEKYMKDGSLRQVYKEVEEPLDIVLYSVQIFTGNI 1471
P RWLA ++D + RE + + + L + +Y V + TG +
Sbjct: 10 PVQRWLARDQEDGEICREF-----------------PLLSKGQPVLPVTIYEVNVATGEL 52
Query: 1472 PGAGTDAKVYITIYGDLGDTGERYLGKSENRTNKFERGTADTFIIEAADLGVIYKIKLRH 1531
AGT A VYI+I+G+ GDTG R L +S++ N F RG DTF +EA LG + KI + H
Sbjct: 53 WNAGTVANVYISIHGEKGDTGSRQLFRSKSSFN-FLRGQTDTFFLEAVHLGDLCKIVIGH 111
Query: 1532 DNSKWCADWYVEKVEIWNDTNEDEFLFLCGRWLSLKKEDGRLERLFYEKE 1581
D W+++ V I + T E+ F C RWL ++D ++ R Y ++
Sbjct: 112 DGLGPGNGWFLDDVVIKDPTTNYEYAFFCHRWLDQGEDDCKIVRELYARD 161
Score = 95.9 bits (237), Expect = 4e-19
Identities = 55/127 (43%), Positives = 75/127 (59%), Gaps = 2/127 (1%)
Query: 2084 SKVQSLVPVK-YEVIVTTGYEPGAGTDANVFVTIFGANGDTGKREL-KQKMRNLFERGST 2141
SK Q ++PV YEV V TG AGT ANV+++I G GDTG R+L + K F RG T
Sbjct: 32 SKGQPVLPVTIYEVNVATGELWNAGTVANVYISIHGEKGDTGSRQLFRSKSSFNFLRGQT 91
Query: 2142 DRFFLETLELGELRKVRLEHDSSGYCSGWLVEKVEVTNTSTGVATIFNCGRWLDKKRGDG 2201
D FFLE + LG+L K+ + HD G +GW ++ V + + +T F C RWLD+ D
Sbjct: 92 DTFFLEAVHLGDLCKIVIGHDGLGPGNGWFLDDVVIKDPTTNYEYAFFCHRWLDQGEDDC 151
Query: 2202 LTWRDLF 2208
R+L+
Sbjct: 152 KIVRELY 158
Score = 92.8 bits (229), Expect = 3e-18
Identities = 57/165 (34%), Positives = 85/165 (51%), Gaps = 1/165 (0%)
Query: 1783 MNTGDLTMFYYGDWLSQRKGKKTLVCEMCAVIDEEEMMEWTSYTVAVKTSDILGAGTDAN 1842
MN+G WL++ + + E + + ++ T Y V V T ++ AGT AN
Sbjct: 1 MNSGKQFYVPVQRWLARDQEDGEICREFPLLSKGQPVLPVTIYEVNVATGELWNAGTVAN 60
Query: 1843 VFIIIFGENGDSGTLALKQSANWNKFERNNTDTFNFPDMLSLGHLCKLRVWHDNKGIFPG 1902
V+I I GE GD+G+ L +S + F R TDTF F + + LG LCK+ + HD G G
Sbjct: 61 VYISIHGEKGDTGSRQLFRSKSSFNFLRGQTDTF-FLEAVHLGDLCKIVIGHDGLGPGNG 119
Query: 1903 WHLSYVDVKDNSRDETFHFQCDCWLSKSEGDGQTVRDFACANNKI 1947
W L V +KD + + + F C WL + E D + VR+ +N I
Sbjct: 120 WFLDDVVIKDPTTNYEYAFFCHRWLDQGEDDCKIVRELYARDNSI 164
Score = 90.5 bits (223), Expect = 2e-17
Identities = 64/227 (28%), Positives = 111/227 (48%), Gaps = 41/227 (18%)
Query: 422 LKKFPWSLWVWTTDLKKAGTNSPIFIQIYGQKGRTDEILLNPNN--KWFKPGIIEKFRIE 479
L + W + V T + GT + + + +YG KG T I L ++ + F PG ++F++
Sbjct: 535 LSEDEWKVLVLTGN---TGTQANVTLWVYGDKGVTGPISLRKDSSEQLFLPGHEDEFQV- 590
Query: 480 LPDLGRFYKIRVWHDKRSSGSGWHLERMTLMNTLNKDKYNFNCNRWLDANEDDNEIVREM 539
T+ + +K +F N WL + D ++V E+
Sbjct: 591 ----------------------------TMQHMKSKKILDFAANVWLSRIQADGDVVCEL 622
Query: 540 TAEGPTVR--RIMGMARYHVTVCTGELEGAGTDANVYLCLFGDVGDTGERLLYNCRNNTD 597
P V+ + + RY V V TG+L+ A T++ V+LCLFG+ GD+G R LY N
Sbjct: 623 ----PVVKGGQAIFPLRYQVDVYTGQLKHAETESEVFLCLFGERGDSGLRQLYK-SNMQV 677
Query: 598 LFEKGNADEFTIESVTMRNVRRVRIRHDGKGSGSGWYLDRVLVREEG 644
F++G D+F + +V++ +++V +R + WY ++V+VRE G
Sbjct: 678 KFQRGQIDKFQVAAVSLGKLQKVLLRCEASDKSQYWYCEQVIVREPG 724
Score = 90.1 bits (222), Expect = 2e-17
Identities = 53/126 (42%), Positives = 74/126 (58%), Gaps = 5/126 (3%)
Query: 778 GKQYTFPANRWLDKNQADGRLEVELYP--SEVVEIQKLVHYEVEIWTGDVGGAGTSARVY 835
GKQ+ P RWL ++Q DG + E +P S+ + + YEV + TG++ AGT A VY
Sbjct: 4 GKQFYVPVQRWLARDQEDGEICRE-FPLLSKGQPVLPVTIYEVNVATGELWNAGTVANVY 62
Query: 836 MQIYGEKGKT--EVLFLSSRSKVFERASKDTFQLEAADVGEVYKLRLGHTGEGFGPSWFV 893
+ I+GEKG T LF S S F R DTF LEA +G++ K+ +GH G G G WF+
Sbjct: 63 ISIHGEKGDTGSRQLFRSKSSFNFLRGQTDTFFLEAVHLGDLCKIVIGHDGLGPGNGWFL 122
Query: 894 DTVWLR 899
D V ++
Sbjct: 123 DDVVIK 128
Score = 88.6 bits (218), Expect = 6e-17
Identities = 59/181 (32%), Positives = 93/181 (51%), Gaps = 6/181 (3%)
Query: 386 TGIQQTFPCSNWLDEKKADGLIERQLYEMVSLRKKRLKKFPWSLWVWTTDLKKAGTNSPI 445
+G Q P WL + DG I R+ + ++S + L + + V T +L AGT + +
Sbjct: 3 SGKQFYVPVQRWLARDQEDGEICRE-FPLLSKGQPVLPVTIYEVNVATGELWNAGTVANV 61
Query: 446 FIQIYGQKGRTD--EILLNPNNKWFKPGIIEKFRIELPDLGRFYKIRVWHDKRSSGSGWH 503
+I I+G+KG T ++ + ++ F G + F +E LG KI + HD G+GW
Sbjct: 62 YISIHGEKGDTGSRQLFRSKSSFNFLRGQTDTFFLEAVHLGDLCKIVIGHDGLGPGNGWF 121
Query: 504 LERMTLMNTLNKDKYNFNCNRWLDANEDDNEIVREMTAEGPTVRRIMGMARYHVTVCTGE 563
L+ + + + +Y F C+RWLD EDD +IVRE+ A I +RYHV G+
Sbjct: 122 LDDVVIKDPTTNYEYAFFCHRWLDQGEDDCKIVRELYARD---NSIFSASRYHVYTFPGK 178
Query: 564 L 564
L
Sbjct: 179 L 179
Score = 84.0 bits (206), Expect = 2e-15
Identities = 68/214 (31%), Positives = 110/214 (51%), Gaps = 20/214 (9%)
Query: 950 DEGEEEESSSSEESSSEEEEMEEEEEEEEFGPGMQEVIEQH--KFEAHRWLARGKEDNEL 1007
D+G S ++SS E++ E+EF MQ + + F A+ WL+R + D ++
Sbjct: 562 DKGVTGPISLRKDSS---EQLFLPGHEDEFQVTMQHMKSKKILDFAANVWLSRIQADGDV 618
Query: 1008 VVELVPAGKPG----PERNTYEVQVVTGNVPKAGTDANVYLTIYGEEYGDTGERPLKKSD 1063
V EL P K G P R Y+V V TG + A T++ V+L ++GE GD+G R L KS+
Sbjct: 619 VCEL-PVVKGGQAIFPLR--YQVDVYTGQLKHAETESEVFLCLFGER-GDSGLRQLYKSN 674
Query: 1064 KSNKFEQGQTDTFTIYAIDLGALTKIRIRHDNTGNRAGWFLDRIDITDMNNEITYYFPCQ 1123
KF++GQ D F + A+ LG L K+ +R + + W+ +++ + + F CQ
Sbjct: 675 MQVKFQRGQIDKFQVAAVSLGKLQKVLLRCEASDKSQYWYCEQVIVREPGTTSESIFTCQ 734
Query: 1124 RWLAVEEDDGQLSRELLPVDE----SYVLPQSEE 1153
++ + Q S +L DE S +L +EE
Sbjct: 735 ---SLPAHNFQASPSMLYRDETVPTSLILKGAEE 765
Score = 83.2 bits (204), Expect = 3e-15
Identities = 54/165 (32%), Positives = 84/165 (50%), Gaps = 13/165 (7%)
Query: 27 ASEDDEGELEHEY---------YKARVYEVVTATGDVRGAGTDANVFITLFGENGLSPKL 77
A + ++GE+ E+ +YEV ATG++ AGT ANV+I++ GE G +
Sbjct: 16 ARDQEDGEICREFPLLSKGQPVLPVTIYEVNVATGELWNAGTVANVYISIHGEKGDTGSR 75
Query: 78 QL-TSKSKSAFEKGNVDVFRVRTNNVGLIYKVRIEHDNTGLNASWYLDHVIVTDMKRPHL 136
QL SKS F +G D F + ++G + K+ I HD G W+LD V++ D +
Sbjct: 76 QLFRSKSSFNFLRGQTDTFFLEAVHLGDLCKIVIGHDGLGPGNGWFLDDVVIKD-PTTNY 134
Query: 137 RYYFNCNNWLSKVEGDRQWCRDLLASFNPMDMPRGNKYEVKVYTG 181
Y F C+ WL + E D + R+L A N + ++Y V + G
Sbjct: 135 EYAFFCHRWLDQGEDDCKIVRELYARDN--SIFSASRYHVYTFPG 177
Score = 79.3 bits (194), Expect = 4e-14
Identities = 58/221 (26%), Positives = 106/221 (47%), Gaps = 37/221 (16%)
Query: 555 YHVTVCTGELEGAGTDANVYLCLFGDVGDTGERLLYNCRNNTDLFEKGNADEFTIESVTM 614
+ V V TG GT ANV L ++GD G TG L ++ LF G+ DEF VTM
Sbjct: 540 WKVLVLTGN---TGTQANVTLWVYGDKGVTGPISLRK-DSSEQLFLPGHEDEF---QVTM 592
Query: 615 RNVRRVRIRHDGKGSGSGWYLDRVLVREEGQPESDNVEFPCLRWLDKDKDDGQLVRELLP 674
++++ +I ++F WL + + DG +V EL
Sbjct: 593 QHMKSKKI----------------------------LDFAANVWLSRIQADGDVVCELPV 624
Query: 675 SDSSATLKNFRYHISLKTGDVSGASTDSRVYIKLYGDKSDTIKQVLLVSDNNLKDYFERG 734
+ RY + + TG + A T+S V++ L+G++ D+ + L S+ +K F+RG
Sbjct: 625 VKGGQAIFPLRYQVDVYTGQLKHAETESEVFLCLFGERGDSGLRQLYKSNMQVK--FQRG 682
Query: 735 RVDEFTLETLNIGNINRLVIGHDSTGMHASWFLGSVQIRVP 775
++D+F + +++G + ++++ +++ W+ V +R P
Sbjct: 683 QIDKFQVAAVSLGKLQKVLLRCEASDKSQYWYCEQVIVREP 723
Score = 79.0 bits (193), Expect = 5e-14
Identities = 59/231 (25%), Positives = 110/231 (47%), Gaps = 39/231 (16%)
Query: 172 NKYEVKVYTGDVIGAGTDADVFINIFGEYGDTG--ERRLENEKDNFEKGAEDRFILDAPD 229
++++V V TG+ GT A+V + ++G+ G TG R ++ + F G ED F
Sbjct: 538 DEWKVLVLTGNT---GTQANVTLWVYGDKGVTGPISLRKDSSEQLFLPGHEDEF------ 588
Query: 230 LGQLMKINVGHNNKGGSAGWFLSQIVIEDIGNKRKYDFPLNRWLALDEDDGKI--QRDIL 287
Q+ ++ + +K+ DF N WL+ + DG + + ++
Sbjct: 589 -----------------------QVTMQHMKSKKILDFAANVWLSRIQADGDVVCELPVV 625
Query: 288 VGGAETTAITYIVTVFTGDVRGAGTKSKIYLVMYGARGNKNSGKIFLEG--GVFDRGRTD 345
GG + Y V V+TG ++ A T+S+++L ++G RG+ +++ F RG+ D
Sbjct: 626 KGGQAIFPLRYQVDVYTGQLKHAETESEVFLCLFGERGDSGLRQLYKSNMQVKFQRGQID 685
Query: 346 IFHIELAVLLSPLSRVSVGHGNVGVNRGWFCEKVVILCPFTGIQQTFPCSN 396
F + AV L L +V + ++ W+CE+V++ P T + F C +
Sbjct: 686 KFQV-AAVSLGKLQKVLLRCEASDKSQYWYCEQVIVREPGTTSESIFTCQS 735
Score = 77.4 bits (189), Expect = 1e-13
Identities = 56/167 (33%), Positives = 81/167 (48%), Gaps = 9/167 (5%)
Query: 1268 GKCMTFPCGRWLAKNEDDGSIIRDLFHAELQTRLYTPFVPYEITLYTSDVFAAGTDANIF 1327
GK P RWLA++++DG I R+ F + + P YE+ + T +++ AGT AN++
Sbjct: 4 GKQFYVPVQRWLARDQEDGEICRE-FPLLSKGQPVLPVTIYEVNVATGELWNAGTVANVY 62
Query: 1328 IIIYGCDAVCTQQKYLCTNKREQKQFFERKSASRFIVELEDVGEIIEKIRIGHNNTGMNP 1387
I I+G + T + L +K F R F +E +G++ KI IGH+ G
Sbjct: 63 ISIHG-EKGDTGSRQLFRSKSSFN--FLRGQTDTFFLEAVHLGDLC-KIVIGHDGLGPGN 118
Query: 1388 GWHCSHVDIRRLLPDKDGAETLTFPCDRWLATSEDDKKTIRELVPYD 1434
GW V I+ D F C RWL EDD K +REL D
Sbjct: 119 GWFLDDVVIK----DPTTNYEYAFFCHRWLDQGEDDCKIVRELYARD 161
Score = 75.1 bits (183), Expect = 7e-13
Identities = 89/394 (22%), Positives = 160/394 (40%), Gaps = 54/394 (13%)
Query: 670 RELLPSDSSATLKNFRYHISLKTGD-------VSGASTDSRVYIKLYGDKSDTIKQVLLV 722
R LPS ++ +++F+ +L + D T + V + +YGDK T + L
Sbjct: 514 RSPLPSSTAKEIRHFQSSETLLSEDEWKVLVLTGNTGTQANVTLWVYGDKGVT-GPISLR 572
Query: 723 SDNNLKDYFERGRVDEFTLETLNIGNINRLVIGHDSTGMHASWFLGSVQIRVPRQGKQYT 782
D++ + F G DEF V ++ + K
Sbjct: 573 KDSS-EQLFLPGHEDEF-----------------------------QVTMQHMKSKKILD 602
Query: 783 FPANRWLDKNQADGRLEVELYPSEVVEIQKLVHYEVEIWTGDVGGAGTSARVYMQIYGEK 842
F AN WL + QADG + EL + + + Y+V+++TG + A T + V++ ++GE+
Sbjct: 603 FAANVWLSRIQADGDVVCELPVVKGGQAIFPLRYQVDVYTGQLKHAETESEVFLCLFGER 662
Query: 843 GKTEV--LFLSSRSKVFERASKDTFQLEAADVGEVYKLRLGHTGEGFGPSWFVDTVWLRH 900
G + + L+ S+ F+R D FQ+ A +G++ K+ L W+ + V
Sbjct: 663 GDSGLRQLYKSNMQVKFQRGQIDKFQVAAVSLGKLQKVLLRCEASDKSQYWYCEQV---- 718
Query: 901 LVVREVDLTPE-----EEARKKKEKDKLRQLLKKERLKAKLQRKKKKRKGSDEEDEGEEE 955
+VRE T E + + L + E + L K + G+ G
Sbjct: 719 -IVREPGTTSESIFTCQSLPAHNFQASPSMLYRDETVPTSLILKGAEEYGTRNRTWG--T 775
Query: 956 ESSSSEESSSEEEEMEEEEEEEEFGPGMQEVIEQHKFEAHRWLARGKEDNELVVELVPAG 1015
S + + + + + + + H A + + + KE + EL
Sbjct: 776 AGSFLLQKKAILKPLIVTSVSQSLFCAYEVKVSVH--GAWKAVLKRKESHGCTQELEWTV 833
Query: 1016 KPGPERNTYEVQVVTGNVPKAGTDANVYLTIYGE 1049
G ++V +VTG++ AGT A V+L +YGE
Sbjct: 834 LAGELDGDWKVTIVTGDLENAGTTATVFLYVYGE 867
Score = 74.3 bits (181), Expect = 1e-12
Identities = 83/331 (25%), Positives = 129/331 (38%), Gaps = 70/331 (21%)
Query: 952 GEEEESSSSEESSSEEEEMEEEEEEEEFGPGMQEVIEQHKFEAHRWLARGKEDNELVVEL 1011
G E S S EEE++ E +++++ P + A R + +E ++
Sbjct: 480 GRENPMGMSATPSQEEEKIHESKKQKKIPPESEARSPLPSSTAKE--IRHFQSSETLLS- 536
Query: 1012 VPAGKPGPERNTYEVQVVTGNVPKAGTDANVYLTIYGEEYGDTGERPLKKSDKSNKFEQG 1071
+ ++V V+TGN GT ANV L +YG++ G TG L+K F G
Sbjct: 537 ---------EDEWKVLVLTGNT---GTQANVTLWVYGDK-GVTGPISLRKDSSEQLFLPG 583
Query: 1072 QTDTFTIYAIDLGALTKIRIRHDNTGNRAGWFLDRIDITDMNNEITYYFPCQRWLAVEED 1131
D F ++ + M ++ F WL+ +
Sbjct: 584 HEDEF-----------------------------QVTMQHMKSKKILDFAANVWLSRIQA 614
Query: 1132 DGQLSRELLPVDESYVLPQSEEGRGGGDNNPLDNLALEQKDKSTTFSVTIKTGVKKNAGT 1191
DG + EL V +GG PL + V + TG K+A T
Sbjct: 615 DGDVVCELPVV------------KGGQAIFPL------------RYQVDVYTGQLKHAET 650
Query: 1192 DANVFITLFGTQDDTGMTLLKSSKTNSDKFERDSIEIFTVETLDLGDLWKVRLGHDNTGK 1251
++ VF+ LFG + D+G+ L S KF+R I+ F V + LG L KV L + + K
Sbjct: 651 ESEVFLCLFGERGDSGLRQLYKSNMQV-KFQRGQIDKFQVAAVSLGKLQKVLLRCEASDK 709
Query: 1252 APGWFVDWVEVDAPSLGKCMTFPCGRWLAKN 1282
+ W+ + V V P F C A N
Sbjct: 710 SQYWYCEQVIVREPGTTSESIFTCQSLPAHN 740
Score = 74.3 bits (181), Expect = 1e-12
Identities = 59/220 (26%), Positives = 104/220 (47%), Gaps = 39/220 (17%)
Query: 45 YEVVTATGDVRGAGTDANVFITLFGENGLSPKLQLTS-KSKSAFEKGNVDVFRVRTNNVG 103
++V+ TG+ GT ANV + ++G+ G++ + L S+ F G+ D F+V +
Sbjct: 540 WKVLVLTGNT---GTQANVTLWVYGDKGVTGPISLRKDSSEQLFLPGHEDEFQVTMQH-- 594
Query: 104 LIYKVRIEHDNTGLNASWYLDHVIVTDMKRPHLRYYFNCNNWLSKVEGDRQWCRDL-LAS 162
+ + LD F N WLS+++ D +L +
Sbjct: 595 -------------MKSKKILD---------------FAANVWLSRIQADGDVVCELPVVK 626
Query: 163 FNPMDMPRGNKYEVKVYTGDVIGAGTDADVFINIFGEYGDTGERRL--ENEKDNFEKGAE 220
P +Y+V VYTG + A T+++VF+ +FGE GD+G R+L N + F++G
Sbjct: 627 GGQAIFPL--RYQVDVYTGQLKHAETESEVFLCLFGERGDSGLRQLYKSNMQVKFQRGQI 684
Query: 221 DRFILDAPDLGQLMKINVGHNNKGGSAGWFLSQIVIEDIG 260
D+F + A LG+L K+ + S W+ Q+++ + G
Sbjct: 685 DKFQVAAVSLGKLQKVLLRCEASDKSQYWYCEQVIVREPG 724
Score = 73.9 bits (180), Expect = 2e-12
Identities = 40/105 (38%), Positives = 62/105 (59%), Gaps = 1/105 (0%)
Query: 2087 QSLVPVKYEVIVTTGYEPGAGTDANVFVTIFGANGDTGKREL-KQKMRNLFERGSTDRFF 2145
Q++ P++Y+V V TG A T++ VF+ +FG GD+G R+L K M+ F+RG D+F
Sbjct: 629 QAIFPLRYQVDVYTGQLKHAETESEVFLCLFGERGDSGLRQLYKSNMQVKFQRGQIDKFQ 688
Query: 2146 LETLELGELRKVRLEHDSSGYCSGWLVEKVEVTNTSTGVATIFNC 2190
+ + LG+L+KV L ++S W E+V V T +IF C
Sbjct: 689 VAAVSLGKLQKVLLRCEASDKSQYWYCEQVIVREPGTTSESIFTC 733
Score = 71.6 bits (174), Expect = 8e-12
Identities = 39/118 (33%), Positives = 65/118 (55%), Gaps = 2/118 (1%)
Query: 1697 LYEMTVWTGDVVGGGTDSNIFMTLYGINGSTEEMQLDKKKARFE--REQNDTFIMEILDI 1754
+YE+ V TG++ GT +N++++++G G T QL + K+ F R Q DTF +E + +
Sbjct: 42 IYEVNVATGELWNAGTVANVYISIHGEKGDTGSRQLFRSKSSFNFLRGQTDTFFLEAVHL 101
Query: 1755 APFTKMRIRIDGLGSRPEWFLERILLKNMNTGDLTMFYYGDWLSQRKGKKTLVCEMCA 1812
K+ I DGLG WFL+ +++K+ T F+ WL Q + +V E+ A
Sbjct: 102 GDLCKIVIGHDGLGPGNGWFLDDVVIKDPTTNYEYAFFCHRWLDQGEDDCKIVRELYA 159
Score = 68.9 bits (167), Expect = 5e-11
Identities = 36/99 (36%), Positives = 56/99 (56%), Gaps = 1/99 (1%)
Query: 1462 YSVQIFTGNIPGAGTDAKVYITIYGDLGDTGERYLGKSENRTNKFERGTADTFIIEAADL 1521
Y V ++TG + A T+++V++ ++G+ GD+G R L KS N KF+RG D F + A L
Sbjct: 636 YQVDVYTGQLKHAETESEVFLCLFGERGDSGLRQLYKS-NMQVKFQRGQIDKFQVAAVSL 694
Query: 1522 GVIYKIKLRHDNSKWCADWYVEKVEIWNDTNEDEFLFLC 1560
G + K+ LR + S WY E+V + E +F C
Sbjct: 695 GKLQKVLLRCEASDKSQYWYCEQVIVREPGTTSESIFTC 733
Score = 58.2 bits (139), Expect = 9e-08
Identities = 56/228 (24%), Positives = 93/228 (40%), Gaps = 36/228 (15%)
Query: 1698 YEMTVWTGDVVGGGTDSNIFMTLYGINGSTEEMQL--DKKKARFEREQNDTFIMEILDIA 1755
+++ V TG+ GT +N+ + +YG G T + L D + F D F
Sbjct: 540 WKVLVLTGNT---GTQANVTLWVYGDKGVTGPISLRKDSSEQLFLPGHEDEF-------- 588
Query: 1756 PFTKMRIRIDGLGSRPEWFLERILLKNMNTGDLTMFYYGDWLSQRKGKKTLVCEMCAVID 1815
++ +++M + + F WLS+ + +VCE+ V
Sbjct: 589 ---------------------QVTMQHMKSKKILDFAANVWLSRIQADGDVVCELPVVKG 627
Query: 1816 EEEMMEWTSYTVAVKTSDILGAGTDANVFIIIFGENGDSGTLALKQSANWNKFERNNTDT 1875
+ + Y V V T + A T++ VF+ +FGE GDSG L +S KF+R D
Sbjct: 628 GQAIFP-LRYQVDVYTGQLKHAETESEVFLCLFGERGDSGLRQLYKSNMQVKFQRGQIDK 686
Query: 1876 FNFPDMLSLGHLCKLRVWHDNKGIFPGWHLSYVDVKDNSRDETFHFQC 1923
F +SLG L K+ + + W+ V V++ F C
Sbjct: 687 FQVA-AVSLGKLQKVLLRCEASDKSQYWYCEQVIVREPGTTSESIFTC 733
Score = 57.4 bits (137), Expect = 2e-07
Identities = 98/443 (22%), Positives = 163/443 (36%), Gaps = 118/443 (26%)
Query: 1462 YSVQIFTGNIPGAGTDAKVYITIYGDLGDTGERYLGKSENRTNKFERGTADTFIIEAADL 1521
+ V + TGN GT A V + +YGD G TG L K + F G D F
Sbjct: 540 WKVLVLTGN---TGTQANVTLWVYGDKGVTGPISLRKDSSE-QLFLPGHEDEF------- 588
Query: 1522 GVIYKIKLRHDNSKWCADWYVEKVEIWNDTNEDEFLFLCGRWLSLKKEDGRLERLFYEKE 1581
++ ++H SK D F WLS + DG +
Sbjct: 589 ----QVTMQHMKSKKILD------------------FAANVWLSRIQADGDVV------- 619
Query: 1582 YTGDRSSNCSSPADFWEIALSSKMADVDISTVTGPMADYVQEGPIIPYYVSVTTGKHKDA 1641
C P V G A + + Y V V TG+ K A
Sbjct: 620 --------CELPV------------------VKGGQAIFP-----LRYQVDVYTGQLKHA 648
Query: 1642 ATDSRAFIFLIGE-DDERSKRIWLDYPRGKRGFSRGSVEEFYVAGLDVGIIKKI----EV 1696
T+S F+ L GE D ++++ + K F RG +++F VA + +G ++K+ E
Sbjct: 649 ETESEVFLCLFGERGDSGLRQLYKSNMQVK--FQRGQIDKFQVAAVSLGKLQKVLLRCEA 706
Query: 1697 LYEMTVWTGDVV----GGGTDSNIFMTLYGINGSTEEMQLDKKKARFEREQNDTFIMEIL 1752
+ W + V G T +IF + + + +A D + L
Sbjct: 707 SDKSQYWYCEQVIVREPGTTSESIF--------TCQSLPAHNFQASPSMLYRDETVPTSL 758
Query: 1753 DIAPFTKMRIRIDGLGSRPEWFLER------ILLKNMNTG-----DLTMFYYGDWLSQRK 1801
+ + R G+ + L++ +++ +++ ++ + +G W + K
Sbjct: 759 ILKGAEEYGTRNRTWGTAGSFLLQKKAILKPLIVTSVSQSLFCAYEVKVSVHGAWKAVLK 818
Query: 1802 GKKTLVCEMCAVIDEEEMMEWT--------SYTVAVKTSDILGAGTDANVFIIIFGENGD 1853
K++ C + +EWT + V + T D+ AGT A VF+ ++GE
Sbjct: 819 RKESHGC--------TQELEWTVLAGELDGDWKVTIVTGDLENAGTTATVFLYVYGETKC 870
Query: 1854 SGTLALKQSANWNKFERNNTDTF 1876
SG + L S F N D F
Sbjct: 871 SGPIIL-GSGKHQLFNPNTADIF 892
Score = 55.8 bits (133), Expect = 4e-07
Identities = 40/142 (28%), Positives = 65/142 (45%), Gaps = 11/142 (7%)
Query: 1919 FHFQCDCWLSKSEGDGQTVRDFACANNKICDELEETTYEIVIETG---NGGETRENVWLI 1975
F+ WL++ + DG+ R+F + K L T YE+ + TG N G T NV++
Sbjct: 7 FYVPVQRWLARDQEDGEICREFPLLS-KGQPVLPVTIYEVNVATGELWNAG-TVANVYIS 64
Query: 1976 LEGRKNRSKEFLMENSSRQRAFRKGTTDTFEFDSIYLGDIASLCVGHLAREDRFIPKREL 2035
+ G K + + S F +G TDTF ++++LGD+ + +GH D P
Sbjct: 65 IHGEKGDTGSRQLFRSKSSFNFLRGQTDTFFLEAVHLGDLCKIVIGH----DGLGPGN-- 118
Query: 2036 AWHVKTITITEMEYGNVYFFNC 2057
W + + I + Y F C
Sbjct: 119 GWFLDDVVIKDPTTNYEYAFFC 140
Score = 49.3 bits (116), Expect = 4e-05
Identities = 49/246 (19%), Positives = 98/246 (39%), Gaps = 43/246 (17%)
Query: 1817 EEMMEWTSYTVAVKTSDILGAGTDANVFIIIFGENGDSGTLALKQSANWNKFERNNTDTF 1876
E ++ + V V T + GT ANV + ++G+ G +G ++L++ ++ F + D F
Sbjct: 532 ETLLSEDEWKVLVLTGN---TGTQANVTLWVYGDKGVTGPISLRKDSSEQLFLPGHEDEF 588
Query: 1877 NFPDMLSLGHLCKLRVWHDNKGIFPGWHLSYVDVKDNSRDETFHFQCDCWLSKSEGDGQT 1936
+++ H+ ++ F + WLS+ + DG
Sbjct: 589 Q----VTMQHMKSKKI--------------------------LDFAANVWLSRIQADGDV 618
Query: 1937 VRDFACANNKICDELEETTYEIVIETG--NGGETRENVWLILEGRKNRSKEFLMENSSRQ 1994
V + K + Y++ + TG ET V+L L G + S + S+ Q
Sbjct: 619 VCELPVV--KGGQAIFPLRYQVDVYTGQLKHAETESEVFLCLFGERGDSGLRQLYKSNMQ 676
Query: 1995 RAFRKGTTDTFEFDSIYLGDIASLCVGHLAREDRFIPKRELAWHVKTITITEMEYGNVYF 2054
F++G D F+ ++ LG + + + A + + W+ + + + E +
Sbjct: 677 VKFQRGQIDKFQVAAVSLGKLQKVLLRCEASD------KSQYWYCEQVIVREPGTTSESI 730
Query: 2055 FNCDCL 2060
F C L
Sbjct: 731 FTCQSL 736
Score = 44.3 bits (103), Expect = 0.001
Identities = 34/135 (25%), Positives = 63/135 (46%), Gaps = 8/135 (5%)
Query: 392 FPCSNWLDEKKADGLIERQLYEMVSLRKKRLKKFP--WSLWVWTTDLKKAGTNSPIFIQI 449
F + WL +ADG + +L + K FP + + V+T LK A T S +F+ +
Sbjct: 603 FAANVWLSRIQADGDVVCEL----PVVKGGQAIFPLRYQVDVYTGQLKHAETESEVFLCL 658
Query: 450 YGQKGRTDEILLNPNNKW--FKPGIIEKFRIELPDLGRFYKIRVWHDKRSSGSGWHLERM 507
+G++G + L +N F+ G I+KF++ LG+ K+ + + W+ E++
Sbjct: 659 FGERGDSGLRQLYKSNMQVKFQRGQIDKFQVAAVSLGKLQKVLLRCEASDKSQYWYCEQV 718
Query: 508 TLMNTLNKDKYNFNC 522
+ + F C
Sbjct: 719 IVREPGTTSESIFTC 733
Score = 40.8 bits (94), Expect = 0.015
Identities = 44/221 (19%), Positives = 95/221 (42%), Gaps = 39/221 (17%)
Query: 1177 FSVTIKTGVKKNAGTDANVFITLFGTQDDTGMTLLKSSKTNSDKFERDSIEIFTVETLDL 1236
+ V + TG N GT ANV + ++G + TG L+ +DS E +
Sbjct: 540 WKVLVLTG---NTGTQANVTLWVYGDKGVTGPISLR----------KDSSEQLFLP---- 582
Query: 1237 GDLWKVRLGHDNTGKAPGWFVDWVEVDAPSLGKCMTFPCGRWLAKNEDDGSIIRDLFHAE 1296
GH++ + V + K + F WL++ + DG ++ +L +
Sbjct: 583 --------GHEDEFQ--------VTMQHMKSKKILDFAANVWLSRIQADGDVVCELPVVK 626
Query: 1297 LQTRLYTPFVPYEITLYTSDVFAAGTDANIFIIIYGCDAVCTQQKYLCTNKREQKQFFER 1356
++ + Y++ +YT + A T++ +F+ ++G ++ +N + + F+R
Sbjct: 627 GGQAIFP--LRYQVDVYTGQLKHAETESEVFLCLFGERGDSGLRQLYKSNMQVK---FQR 681
Query: 1357 KSASRFIVELEDVGEIIEKIRIGHNNTGMNPGWHCSHVDIR 1397
+F V +G+ ++K+ + + + W+C V +R
Sbjct: 682 GQIDKFQVAAVSLGK-LQKVLLRCEASDKSQYWYCEQVIVR 721
Score = 38.5 bits (88), Expect = 0.074
Identities = 18/52 (34%), Positives = 27/52 (51%)
Query: 45 YEVVTATGDVRGAGTDANVFITLFGENGLSPKLQLTSKSKSAFEKGNVDVFR 96
++V TGD+ AGT A VF+ ++GE S + L S F D+F+
Sbjct: 842 WKVTIVTGDLENAGTTATVFLYVYGETKCSGPIILGSGKHQLFNPNTADIFK 893
Score = 36.2 bits (82), Expect = 0.37
Identities = 21/51 (41%), Positives = 29/51 (56%), Gaps = 5/51 (9%)
Query: 300 VTVFTGDVRGAGTKSKIYLVMYGARGNKNSGKIFLEGG---VFDRGRTDIF 347
VT+ TGD+ AGT + ++L +YG K SG I L G +F+ DIF
Sbjct: 844 VTIVTGDLENAGTTATVFLYVYGE--TKCSGPIILGSGKHQLFNPNTADIF 892
Score = 35.4 bits (80), Expect = 0.63
Identities = 18/52 (34%), Positives = 32/52 (61%), Gaps = 1/52 (1%)
Query: 816 YEVEIWTGDVGGAGTSARVYMQIYGE-KGKTEVLFLSSRSKVFERASKDTFQ 866
++V I TGD+ AGT+A V++ +YGE K ++ S + ++F + D F+
Sbjct: 842 WKVTIVTGDLENAGTTATVFLYVYGETKCSGPIILGSGKHQLFNPNTADIFK 893
Score = 33.5 bits (75), Expect = 2.4
Identities = 20/53 (37%), Positives = 30/53 (56%), Gaps = 2/53 (3%)
Query: 1177 FSVTIKTGVKKNAGTDANVFITLFGTQDDTGMTLLKSSKTNSDKFERDSIEIF 1229
+ VTI TG +NAGT A VF+ ++G +G +L S K F ++ +IF
Sbjct: 842 WKVTIVTGDLENAGTTATVFLYVYGETKCSGPIILGSGK--HQLFNPNTADIF 892
Score = 32.7 bits (73), Expect = 4.1
Identities = 24/69 (34%), Positives = 31/69 (44%), Gaps = 4/69 (5%)
Query: 2077 KTTESFASKVQSLVPVKYEVIVTTGYEPGAGTDANVFVTIFGANGDTGKREL-KQKMRNL 2135
K F S L +++V+V TG GT ANV + ++G G TG L K L
Sbjct: 523 KEIRHFQSSETLLSEDEWKVLVLTG---NTGTQANVTLWVYGDKGVTGPISLRKDSSEQL 579
Query: 2136 FERGSTDRF 2144
F G D F
Sbjct: 580 FLPGHEDEF 588
>gi|239756622 PREDICTED: polycystic kidney disease 1-like 3 [Homo
sapiens]
Length = 1732
Score = 81.3 bits (199), Expect = 1e-14
Identities = 46/111 (41%), Positives = 66/111 (59%), Gaps = 6/111 (5%)
Query: 45 YEVVTATGDVRGAGTDANVFITLFGENGLSPKLQLTSKSKSAFEKGNVDVFRVRT-NNVG 103
Y + TG R A T A V ITL+G G S L K+ FE+G +DVF + T ++G
Sbjct: 745 YLIQVYTGYRRSAATTAKVVITLYGSEGRSEPHHLCDPQKTVFERGGLDVFLLTTWTSLG 804
Query: 104 LIYKVRIEHDNTGLNASWYLDHVIVTDM--KRPHLRYYFNCNNWLSKVEGD 152
++ +R+ HDN+G++ SWY+ VIV DM KR +++F CN WL+ GD
Sbjct: 805 NLHSLRLWHDNSGVSPSWYVSQVIVCDMAVKR---KWHFLCNCWLAVDLGD 852
Score = 79.0 bits (193), Expect = 5e-14
Identities = 49/155 (31%), Positives = 71/155 (45%), Gaps = 5/155 (3%)
Query: 1825 YTVAVKTSDILGAGTDANVFIIIFGENGDSGTLALKQSANWNKFERNNTDTFNFPDMLSL 1884
Y + V T A T A V I ++G G S L FER D F SL
Sbjct: 745 YLIQVYTGYRRSAATTAKVVITLYGSEGRSEPHHLCDPQK-TVFERGGLDVFLLTTWTSL 803
Query: 1885 GHLCKLRVWHDNKGIFPGWHLSYVDVKDNSRDETFHFQCDCWLSKSEGDGQTVRDFACAN 1944
G+L LR+WHDN G+ P W++S V V D + +HF C+CWL+ GD + R F +
Sbjct: 804 GNLHSLRLWHDNSGVSPSWYVSQVIVCDMAVKRKWHFLCNCWLAVDLGDCELDRVFIPVS 863
Query: 1945 NKICDELEETTYEIVIETGNGGETRENVWLILEGR 1979
+ +++E T++ +WL + R
Sbjct: 864 KRELFSFRHLFSSMIVEK----FTQDYLWLSIATR 894
Score = 75.1 bits (183), Expect = 7e-13
Identities = 42/113 (37%), Positives = 64/113 (56%), Gaps = 2/113 (1%)
Query: 174 YEVKVYTGDVIGAGTDADVFINIFGEYGDTGERRL-ENEKDNFEKGAEDRFILDA-PDLG 231
Y ++VYTG A T A V I ++G G + L + +K FE+G D F+L LG
Sbjct: 745 YLIQVYTGYRRSAATTAKVVITLYGSEGRSEPHHLCDPQKTVFERGGLDVFLLTTWTSLG 804
Query: 232 QLMKINVGHNNKGGSAGWFLSQIVIEDIGNKRKYDFPLNRWLALDEDDGKIQR 284
L + + H+N G S W++SQ+++ D+ KRK+ F N WLA+D D ++ R
Sbjct: 805 NLHSLRLWHDNSGVSPSWYVSQVIVCDMAVKRKWHFLCNCWLAVDLGDCELDR 857
Score = 73.2 bits (178), Expect = 3e-12
Identities = 41/117 (35%), Positives = 65/117 (55%), Gaps = 3/117 (2%)
Query: 1462 YSVQIFTGNIPGAGTDAKVYITIYGDLGDTGERYLGKSENRTNKFERGTADTFIIEA-AD 1520
Y +Q++TG A T AKV IT+YG G + +L + + FERG D F++
Sbjct: 745 YLIQVYTGYRRSAATTAKVVITLYGSEGRSEPHHL--CDPQKTVFERGGLDVFLLTTWTS 802
Query: 1521 LGVIYKIKLRHDNSKWCADWYVEKVEIWNDTNEDEFLFLCGRWLSLKKEDGRLERLF 1577
LG ++ ++L HDNS WYV +V + + + ++ FLC WL++ D L+R+F
Sbjct: 803 LGNLHSLRLWHDNSGVSPSWYVSQVIVCDMAVKRKWHFLCNCWLAVDLGDCELDRVF 859
Score = 70.9 bits (172), Expect = 1e-11
Identities = 43/122 (35%), Positives = 65/122 (53%), Gaps = 3/122 (2%)
Query: 1024 YEVQVVTGNVPKAGTDANVYLTIYGEEYGDTGERPLKKSDKSNKFEQGQTDTFTIYA-ID 1082
Y +QV TG A T A V +T+YG E G + L K+ FE+G D F +
Sbjct: 745 YLIQVYTGYRRSAATTAKVVITLYGSE-GRSEPHHLCDPQKT-VFERGGLDVFLLTTWTS 802
Query: 1083 LGALTKIRIRHDNTGNRAGWFLDRIDITDMNNEITYYFPCQRWLAVEEDDGQLSRELLPV 1142
LG L +R+ HDN+G W++ ++ + DM + ++F C WLAV+ D +L R +PV
Sbjct: 803 LGNLHSLRLWHDNSGVSPSWYVSQVIVCDMAVKRKWHFLCNCWLAVDLGDCELDRVFIPV 862
Query: 1143 DE 1144
+
Sbjct: 863 SK 864
Score = 69.3 bits (168), Expect = 4e-11
Identities = 40/108 (37%), Positives = 53/108 (49%), Gaps = 1/108 (0%)
Query: 2094 YEVIVTTGYEPGAGTDANVFVTIFGANGDTGKRELKQKMRNLFERGSTDRFFLET-LELG 2152
Y + V TGY A T A V +T++G+ G + L + +FERG D F L T LG
Sbjct: 745 YLIQVYTGYRRSAATTAKVVITLYGSEGRSEPHHLCDPQKTVFERGGLDVFLLTTWTSLG 804
Query: 2153 ELRKVRLEHDSSGYCSGWLVEKVEVTNTSTGVATIFNCGRWLDKKRGD 2200
L +RL HD+SG W V +V V + + F C WL GD
Sbjct: 805 NLHSLRLWHDNSGVSPSWYVSQVIVCDMAVKRKWHFLCNCWLAVDLGD 852
Score = 63.2 bits (152), Expect = 3e-09
Identities = 46/156 (29%), Positives = 78/156 (50%), Gaps = 5/156 (3%)
Query: 661 KDKDDGQLVRELLPSDSSATLKNFRYHISLKTGDVSGASTDSRVYIKLYGDKSDTIKQVL 720
KD+ D Q V+ + +D+ + + F Y I + TG A+T ++V I LYG + + L
Sbjct: 721 KDQADMQKVKVTVLADNDPSAQ-FHYLIQVYTGYRRSAATTAKVVITLYGSEGRSEPHHL 779
Query: 721 LVSDNNLKDYFERGRVDEFTLET-LNIGNINRLVIGHDSTGMHASWFLGSVQIRVPRQGK 779
+ K FERG +D F L T ++GN++ L + HD++G+ SW++ V + +
Sbjct: 780 C---DPQKTVFERGGLDVFLLTTWTSLGNLHSLRLWHDNSGVSPSWYVSQVIVCDMAVKR 836
Query: 780 QYTFPANRWLDKNQADGRLEVELYPSEVVEIQKLVH 815
++ F N WL + D L+ P E+ H
Sbjct: 837 KWHFLCNCWLAVDLGDCELDRVFIPVSKRELFSFRH 872
Score = 62.0 bits (149), Expect = 6e-09
Identities = 44/127 (34%), Positives = 66/127 (51%), Gaps = 7/127 (5%)
Query: 1168 LEQKDKSTTFSVTIK--TGVKKNAGTDANVFITLFGTQDDTGMT-LLKSSKTNSDKFERD 1224
L D S F I+ TG +++A T A V ITL+G++ + L KT FER
Sbjct: 734 LADNDPSAQFHYLIQVYTGYRRSAATTAKVVITLYGSEGRSEPHHLCDPQKT---VFERG 790
Query: 1225 SIEIFTVET-LDLGDLWKVRLGHDNTGKAPGWFVDWVEVDAPSLGKCMTFPCGRWLAKNE 1283
+++F + T LG+L +RL HDN+G +P W+V V V ++ + F C WLA +
Sbjct: 791 GLDVFLLTTWTSLGNLHSLRLWHDNSGVSPSWYVSQVIVCDMAVKRKWHFLCNCWLAVDL 850
Query: 1284 DDGSIIR 1290
D + R
Sbjct: 851 GDCELDR 857
Score = 61.6 bits (148), Expect = 8e-09
Identities = 33/92 (35%), Positives = 51/92 (55%), Gaps = 2/92 (2%)
Query: 815 HYEVEIWTGDVGGAGTSARVYMQIYGEKGKTEVLFLSSRSK-VFERASKDTFQLEA-ADV 872
HY ++++TG A T+A+V + +YG +G++E L K VFER D F L +
Sbjct: 744 HYLIQVYTGYRRSAATTAKVVITLYGSEGRSEPHHLCDPQKTVFERGGLDVFLLTTWTSL 803
Query: 873 GEVYKLRLGHTGEGFGPSWFVDTVWLRHLVVR 904
G ++ LRL H G PSW+V V + + V+
Sbjct: 804 GNLHSLRLWHDNSGVSPSWYVSQVIVCDMAVK 835
Score = 61.2 bits (147), Expect = 1e-08
Identities = 32/116 (27%), Positives = 61/116 (52%), Gaps = 2/116 (1%)
Query: 424 KFPWSLWVWTTDLKKAGTNSPIFIQIYGQKGRTD-EILLNPNNKWFKPGIIEKFRIEL-P 481
+F + + V+T + A T + + I +YG +GR++ L +P F+ G ++ F +
Sbjct: 742 QFHYLIQVYTGYRRSAATTAKVVITLYGSEGRSEPHHLCDPQKTVFERGGLDVFLLTTWT 801
Query: 482 DLGRFYKIRVWHDKRSSGSGWHLERMTLMNTLNKDKYNFNCNRWLDANEDDNEIVR 537
LG + +R+WHD W++ ++ + + K K++F CN WL + D E+ R
Sbjct: 802 SLGNLHSLRLWHDNSGVSPSWYVSQVIVCDMAVKRKWHFLCNCWLAVDLGDCELDR 857
Score = 58.2 bits (139), Expect = 9e-08
Identities = 34/133 (25%), Positives = 62/133 (46%), Gaps = 1/133 (0%)
Query: 278 DDGKIQRDILVGGAETTAITYIVTVFTGDVRGAGTKSKIYLVMYGARGNKNSGKIF-LEG 336
D K++ +L + Y++ V+TG R A T +K+ + +YG+ G + +
Sbjct: 725 DMQKVKVTVLADNDPSAQFHYLIQVYTGYRRSAATTAKVVITLYGSEGRSEPHHLCDPQK 784
Query: 337 GVFDRGRTDIFHIELAVLLSPLSRVSVGHGNVGVNRGWFCEKVVILCPFTGIQQTFPCSN 396
VF+RG D+F + L L + + H N GV+ W+ +V++ + F C+
Sbjct: 785 TVFERGGLDVFLLTTWTSLGNLHSLRLWHDNSGVSPSWYVSQVIVCDMAVKRKWHFLCNC 844
Query: 397 WLDEKKADGLIER 409
WL D ++R
Sbjct: 845 WLAVDLGDCELDR 857
Score = 55.8 bits (133), Expect = 4e-07
Identities = 42/136 (30%), Positives = 62/136 (45%), Gaps = 6/136 (4%)
Query: 555 YHVTVCTGELEGAGTDANVYLCLFGDVGDTGERLLYNCRNNTDLFEKGNADEFTIESVT- 613
Y + V TG A T A V + L+G G + L C +FE+G D F + + T
Sbjct: 745 YLIQVYTGYRRSAATTAKVVITLYGSEGRSEPHHL--CDPQKTVFERGGLDVFLLTTWTS 802
Query: 614 MRNVRRVRIRHDGKGSGSGWYLDRVLVREEGQPESDNVEFPCLRWLDKDKDDGQLVRELL 673
+ N+ +R+ HD G WY+ +V+V + F C WL D D +L R +
Sbjct: 803 LGNLHSLRLWHDNSGVSPSWYVSQVIVCD--MAVKRKWHFLCNCWLAVDLGDCELDRVFI 860
Query: 674 PSDSSATLKNFRYHIS 689
P S L +FR+ S
Sbjct: 861 PV-SKRELFSFRHLFS 875
Score = 49.7 bits (117), Expect = 3e-05
Identities = 35/125 (28%), Positives = 58/125 (46%), Gaps = 8/125 (6%)
Query: 1308 YEITLYTSDVFAAGTDANIFIIIYGCDAVCTQQKYLCTNKREQKQFFERKSASRFIVELE 1367
Y I +YT +A T A + I +YG + ++ +LC QK FER F++
Sbjct: 745 YLIQVYTGYRRSAATTAKVVITLYGSEGR-SEPHHLCD---PQKTVFERGGLDVFLLTTW 800
Query: 1368 DVGEIIEKIRIGHNNTGMNPGWHCSHVDIRRLLPDKDGAETLTFPCDRWLATSEDDKKTI 1427
+ +R+ H+N+G++P W+ S V ++ D F C+ WLA D +
Sbjct: 801 TSLGNLHSLRLWHDNSGVSPSWYVSQV----IVCDMAVKRKWHFLCNCWLAVDLGDCELD 856
Query: 1428 RELVP 1432
R +P
Sbjct: 857 RVFIP 861
Score = 43.9 bits (102), Expect = 0.002
Identities = 28/103 (27%), Positives = 48/103 (46%), Gaps = 2/103 (1%)
Query: 1698 YEMTVWTGDVVGGGTDSNIFMTLYGINGSTEEMQL-DKKKARFEREQNDTFIMEI-LDIA 1755
Y + V+TG T + + +TLYG G +E L D +K FER D F++ +
Sbjct: 745 YLIQVYTGYRRSAATTAKVVITLYGSEGRSEPHHLCDPQKTVFERGGLDVFLLTTWTSLG 804
Query: 1756 PFTKMRIRIDGLGSRPEWFLERILLKNMNTGDLTMFYYGDWLS 1798
+R+ D G P W++ ++++ +M F WL+
Sbjct: 805 NLHSLRLWHDNSGVSPSWYVSQVIVCDMAVKRKWHFLCNCWLA 847
>gi|239751108 PREDICTED: polycystic kidney disease 1-like 3 [Homo
sapiens]
Length = 1731
Score = 81.3 bits (199), Expect = 1e-14
Identities = 46/111 (41%), Positives = 66/111 (59%), Gaps = 6/111 (5%)
Query: 45 YEVVTATGDVRGAGTDANVFITLFGENGLSPKLQLTSKSKSAFEKGNVDVFRVRT-NNVG 103
Y + TG R A T A V ITL+G G S L K+ FE+G +DVF + T ++G
Sbjct: 745 YLIQVYTGYRRSAATTAKVVITLYGSEGRSEPHHLCDPQKTVFERGGLDVFLLTTWTSLG 804
Query: 104 LIYKVRIEHDNTGLNASWYLDHVIVTDM--KRPHLRYYFNCNNWLSKVEGD 152
++ +R+ HDN+G++ SWY+ VIV DM KR +++F CN WL+ GD
Sbjct: 805 NLHSLRLWHDNSGVSPSWYVSQVIVCDMAVKR---KWHFLCNCWLAVDLGD 852
Score = 79.0 bits (193), Expect = 5e-14
Identities = 49/155 (31%), Positives = 71/155 (45%), Gaps = 5/155 (3%)
Query: 1825 YTVAVKTSDILGAGTDANVFIIIFGENGDSGTLALKQSANWNKFERNNTDTFNFPDMLSL 1884
Y + V T A T A V I ++G G S L FER D F SL
Sbjct: 745 YLIQVYTGYRRSAATTAKVVITLYGSEGRSEPHHLCDPQK-TVFERGGLDVFLLTTWTSL 803
Query: 1885 GHLCKLRVWHDNKGIFPGWHLSYVDVKDNSRDETFHFQCDCWLSKSEGDGQTVRDFACAN 1944
G+L LR+WHDN G+ P W++S V V D + +HF C+CWL+ GD + R F +
Sbjct: 804 GNLHSLRLWHDNSGVSPSWYVSQVIVCDMAVKRKWHFLCNCWLAVDLGDCELDRVFIPVS 863
Query: 1945 NKICDELEETTYEIVIETGNGGETRENVWLILEGR 1979
+ +++E T++ +WL + R
Sbjct: 864 KRELFSFRHLFSSMIVEK----FTQDYLWLSIATR 894
Score = 75.1 bits (183), Expect = 7e-13
Identities = 42/113 (37%), Positives = 64/113 (56%), Gaps = 2/113 (1%)
Query: 174 YEVKVYTGDVIGAGTDADVFINIFGEYGDTGERRL-ENEKDNFEKGAEDRFILDA-PDLG 231
Y ++VYTG A T A V I ++G G + L + +K FE+G D F+L LG
Sbjct: 745 YLIQVYTGYRRSAATTAKVVITLYGSEGRSEPHHLCDPQKTVFERGGLDVFLLTTWTSLG 804
Query: 232 QLMKINVGHNNKGGSAGWFLSQIVIEDIGNKRKYDFPLNRWLALDEDDGKIQR 284
L + + H+N G S W++SQ+++ D+ KRK+ F N WLA+D D ++ R
Sbjct: 805 NLHSLRLWHDNSGVSPSWYVSQVIVCDMAVKRKWHFLCNCWLAVDLGDCELDR 857
Score = 73.2 bits (178), Expect = 3e-12
Identities = 41/117 (35%), Positives = 65/117 (55%), Gaps = 3/117 (2%)
Query: 1462 YSVQIFTGNIPGAGTDAKVYITIYGDLGDTGERYLGKSENRTNKFERGTADTFIIEA-AD 1520
Y +Q++TG A T AKV IT+YG G + +L + + FERG D F++
Sbjct: 745 YLIQVYTGYRRSAATTAKVVITLYGSEGRSEPHHL--CDPQKTVFERGGLDVFLLTTWTS 802
Query: 1521 LGVIYKIKLRHDNSKWCADWYVEKVEIWNDTNEDEFLFLCGRWLSLKKEDGRLERLF 1577
LG ++ ++L HDNS WYV +V + + + ++ FLC WL++ D L+R+F
Sbjct: 803 LGNLHSLRLWHDNSGVSPSWYVSQVIVCDMAVKRKWHFLCNCWLAVDLGDCELDRVF 859
Score = 70.9 bits (172), Expect = 1e-11
Identities = 43/122 (35%), Positives = 65/122 (53%), Gaps = 3/122 (2%)
Query: 1024 YEVQVVTGNVPKAGTDANVYLTIYGEEYGDTGERPLKKSDKSNKFEQGQTDTFTIYA-ID 1082
Y +QV TG A T A V +T+YG E G + L K+ FE+G D F +
Sbjct: 745 YLIQVYTGYRRSAATTAKVVITLYGSE-GRSEPHHLCDPQKT-VFERGGLDVFLLTTWTS 802
Query: 1083 LGALTKIRIRHDNTGNRAGWFLDRIDITDMNNEITYYFPCQRWLAVEEDDGQLSRELLPV 1142
LG L +R+ HDN+G W++ ++ + DM + ++F C WLAV+ D +L R +PV
Sbjct: 803 LGNLHSLRLWHDNSGVSPSWYVSQVIVCDMAVKRKWHFLCNCWLAVDLGDCELDRVFIPV 862
Query: 1143 DE 1144
+
Sbjct: 863 SK 864
Score = 69.3 bits (168), Expect = 4e-11
Identities = 40/108 (37%), Positives = 53/108 (49%), Gaps = 1/108 (0%)
Query: 2094 YEVIVTTGYEPGAGTDANVFVTIFGANGDTGKRELKQKMRNLFERGSTDRFFLET-LELG 2152
Y + V TGY A T A V +T++G+ G + L + +FERG D F L T LG
Sbjct: 745 YLIQVYTGYRRSAATTAKVVITLYGSEGRSEPHHLCDPQKTVFERGGLDVFLLTTWTSLG 804
Query: 2153 ELRKVRLEHDSSGYCSGWLVEKVEVTNTSTGVATIFNCGRWLDKKRGD 2200
L +RL HD+SG W V +V V + + F C WL GD
Sbjct: 805 NLHSLRLWHDNSGVSPSWYVSQVIVCDMAVKRKWHFLCNCWLAVDLGD 852
Score = 63.2 bits (152), Expect = 3e-09
Identities = 46/156 (29%), Positives = 78/156 (50%), Gaps = 5/156 (3%)
Query: 661 KDKDDGQLVRELLPSDSSATLKNFRYHISLKTGDVSGASTDSRVYIKLYGDKSDTIKQVL 720
KD+ D Q V+ + +D+ + + F Y I + TG A+T ++V I LYG + + L
Sbjct: 721 KDQADMQKVKVTVLADNDPSAQ-FHYLIQVYTGYRRSAATTAKVVITLYGSEGRSEPHHL 779
Query: 721 LVSDNNLKDYFERGRVDEFTLET-LNIGNINRLVIGHDSTGMHASWFLGSVQIRVPRQGK 779
+ K FERG +D F L T ++GN++ L + HD++G+ SW++ V + +
Sbjct: 780 C---DPQKTVFERGGLDVFLLTTWTSLGNLHSLRLWHDNSGVSPSWYVSQVIVCDMAVKR 836
Query: 780 QYTFPANRWLDKNQADGRLEVELYPSEVVEIQKLVH 815
++ F N WL + D L+ P E+ H
Sbjct: 837 KWHFLCNCWLAVDLGDCELDRVFIPVSKRELFSFRH 872
Score = 62.0 bits (149), Expect = 6e-09
Identities = 44/127 (34%), Positives = 66/127 (51%), Gaps = 7/127 (5%)
Query: 1168 LEQKDKSTTFSVTIK--TGVKKNAGTDANVFITLFGTQDDTGMT-LLKSSKTNSDKFERD 1224
L D S F I+ TG +++A T A V ITL+G++ + L KT FER
Sbjct: 734 LADNDPSAQFHYLIQVYTGYRRSAATTAKVVITLYGSEGRSEPHHLCDPQKT---VFERG 790
Query: 1225 SIEIFTVET-LDLGDLWKVRLGHDNTGKAPGWFVDWVEVDAPSLGKCMTFPCGRWLAKNE 1283
+++F + T LG+L +RL HDN+G +P W+V V V ++ + F C WLA +
Sbjct: 791 GLDVFLLTTWTSLGNLHSLRLWHDNSGVSPSWYVSQVIVCDMAVKRKWHFLCNCWLAVDL 850
Query: 1284 DDGSIIR 1290
D + R
Sbjct: 851 GDCELDR 857
Score = 61.6 bits (148), Expect = 8e-09
Identities = 33/92 (35%), Positives = 51/92 (55%), Gaps = 2/92 (2%)
Query: 815 HYEVEIWTGDVGGAGTSARVYMQIYGEKGKTEVLFLSSRSK-VFERASKDTFQLEA-ADV 872
HY ++++TG A T+A+V + +YG +G++E L K VFER D F L +
Sbjct: 744 HYLIQVYTGYRRSAATTAKVVITLYGSEGRSEPHHLCDPQKTVFERGGLDVFLLTTWTSL 803
Query: 873 GEVYKLRLGHTGEGFGPSWFVDTVWLRHLVVR 904
G ++ LRL H G PSW+V V + + V+
Sbjct: 804 GNLHSLRLWHDNSGVSPSWYVSQVIVCDMAVK 835
Score = 61.2 bits (147), Expect = 1e-08
Identities = 32/116 (27%), Positives = 61/116 (52%), Gaps = 2/116 (1%)
Query: 424 KFPWSLWVWTTDLKKAGTNSPIFIQIYGQKGRTD-EILLNPNNKWFKPGIIEKFRIEL-P 481
+F + + V+T + A T + + I +YG +GR++ L +P F+ G ++ F +
Sbjct: 742 QFHYLIQVYTGYRRSAATTAKVVITLYGSEGRSEPHHLCDPQKTVFERGGLDVFLLTTWT 801
Query: 482 DLGRFYKIRVWHDKRSSGSGWHLERMTLMNTLNKDKYNFNCNRWLDANEDDNEIVR 537
LG + +R+WHD W++ ++ + + K K++F CN WL + D E+ R
Sbjct: 802 SLGNLHSLRLWHDNSGVSPSWYVSQVIVCDMAVKRKWHFLCNCWLAVDLGDCELDR 857
Score = 58.2 bits (139), Expect = 9e-08
Identities = 34/133 (25%), Positives = 62/133 (46%), Gaps = 1/133 (0%)
Query: 278 DDGKIQRDILVGGAETTAITYIVTVFTGDVRGAGTKSKIYLVMYGARGNKNSGKIF-LEG 336
D K++ +L + Y++ V+TG R A T +K+ + +YG+ G + +
Sbjct: 725 DMQKVKVTVLADNDPSAQFHYLIQVYTGYRRSAATTAKVVITLYGSEGRSEPHHLCDPQK 784
Query: 337 GVFDRGRTDIFHIELAVLLSPLSRVSVGHGNVGVNRGWFCEKVVILCPFTGIQQTFPCSN 396
VF+RG D+F + L L + + H N GV+ W+ +V++ + F C+
Sbjct: 785 TVFERGGLDVFLLTTWTSLGNLHSLRLWHDNSGVSPSWYVSQVIVCDMAVKRKWHFLCNC 844
Query: 397 WLDEKKADGLIER 409
WL D ++R
Sbjct: 845 WLAVDLGDCELDR 857
Score = 55.8 bits (133), Expect = 4e-07
Identities = 42/136 (30%), Positives = 62/136 (45%), Gaps = 6/136 (4%)
Query: 555 YHVTVCTGELEGAGTDANVYLCLFGDVGDTGERLLYNCRNNTDLFEKGNADEFTIESVT- 613
Y + V TG A T A V + L+G G + L C +FE+G D F + + T
Sbjct: 745 YLIQVYTGYRRSAATTAKVVITLYGSEGRSEPHHL--CDPQKTVFERGGLDVFLLTTWTS 802
Query: 614 MRNVRRVRIRHDGKGSGSGWYLDRVLVREEGQPESDNVEFPCLRWLDKDKDDGQLVRELL 673
+ N+ +R+ HD G WY+ +V+V + F C WL D D +L R +
Sbjct: 803 LGNLHSLRLWHDNSGVSPSWYVSQVIVCD--MAVKRKWHFLCNCWLAVDLGDCELDRVFI 860
Query: 674 PSDSSATLKNFRYHIS 689
P S L +FR+ S
Sbjct: 861 PV-SKRELFSFRHLFS 875
Score = 49.7 bits (117), Expect = 3e-05
Identities = 35/125 (28%), Positives = 58/125 (46%), Gaps = 8/125 (6%)
Query: 1308 YEITLYTSDVFAAGTDANIFIIIYGCDAVCTQQKYLCTNKREQKQFFERKSASRFIVELE 1367
Y I +YT +A T A + I +YG + ++ +LC QK FER F++
Sbjct: 745 YLIQVYTGYRRSAATTAKVVITLYGSEGR-SEPHHLCD---PQKTVFERGGLDVFLLTTW 800
Query: 1368 DVGEIIEKIRIGHNNTGMNPGWHCSHVDIRRLLPDKDGAETLTFPCDRWLATSEDDKKTI 1427
+ +R+ H+N+G++P W+ S V ++ D F C+ WLA D +
Sbjct: 801 TSLGNLHSLRLWHDNSGVSPSWYVSQV----IVCDMAVKRKWHFLCNCWLAVDLGDCELD 856
Query: 1428 RELVP 1432
R +P
Sbjct: 857 RVFIP 861
Score = 43.9 bits (102), Expect = 0.002
Identities = 28/103 (27%), Positives = 48/103 (46%), Gaps = 2/103 (1%)
Query: 1698 YEMTVWTGDVVGGGTDSNIFMTLYGINGSTEEMQL-DKKKARFEREQNDTFIMEI-LDIA 1755
Y + V+TG T + + +TLYG G +E L D +K FER D F++ +
Sbjct: 745 YLIQVYTGYRRSAATTAKVVITLYGSEGRSEPHHLCDPQKTVFERGGLDVFLLTTWTSLG 804
Query: 1756 PFTKMRIRIDGLGSRPEWFLERILLKNMNTGDLTMFYYGDWLS 1798
+R+ D G P W++ ++++ +M F WL+
Sbjct: 805 NLHSLRLWHDNSGVSPSWYVSQVIVCDMAVKRKWHFLCNCWLA 847
>gi|239745596 PREDICTED: polycystin 1-like 3 [Homo sapiens]
Length = 1731
Score = 81.3 bits (199), Expect = 1e-14
Identities = 46/111 (41%), Positives = 66/111 (59%), Gaps = 6/111 (5%)
Query: 45 YEVVTATGDVRGAGTDANVFITLFGENGLSPKLQLTSKSKSAFEKGNVDVFRVRT-NNVG 103
Y + TG R A T A V ITL+G G S L K+ FE+G +DVF + T ++G
Sbjct: 745 YLIQVYTGYRRSAATTAKVVITLYGSEGRSEPHHLCDPQKTVFERGGLDVFLLTTWTSLG 804
Query: 104 LIYKVRIEHDNTGLNASWYLDHVIVTDM--KRPHLRYYFNCNNWLSKVEGD 152
++ +R+ HDN+G++ SWY+ VIV DM KR +++F CN WL+ GD
Sbjct: 805 NLHSLRLWHDNSGVSPSWYVSQVIVCDMAVKR---KWHFLCNCWLAVDLGD 852
Score = 79.0 bits (193), Expect = 5e-14
Identities = 49/155 (31%), Positives = 71/155 (45%), Gaps = 5/155 (3%)
Query: 1825 YTVAVKTSDILGAGTDANVFIIIFGENGDSGTLALKQSANWNKFERNNTDTFNFPDMLSL 1884
Y + V T A T A V I ++G G S L FER D F SL
Sbjct: 745 YLIQVYTGYRRSAATTAKVVITLYGSEGRSEPHHLCDPQK-TVFERGGLDVFLLTTWTSL 803
Query: 1885 GHLCKLRVWHDNKGIFPGWHLSYVDVKDNSRDETFHFQCDCWLSKSEGDGQTVRDFACAN 1944
G+L LR+WHDN G+ P W++S V V D + +HF C+CWL+ GD + R F +
Sbjct: 804 GNLHSLRLWHDNSGVSPSWYVSQVIVCDMAVKRKWHFLCNCWLAVDLGDCELDRVFIPVS 863
Query: 1945 NKICDELEETTYEIVIETGNGGETRENVWLILEGR 1979
+ +++E T++ +WL + R
Sbjct: 864 KRELFSFRHLFSSMIVEK----FTQDYLWLSIATR 894
Score = 75.1 bits (183), Expect = 7e-13
Identities = 42/113 (37%), Positives = 64/113 (56%), Gaps = 2/113 (1%)
Query: 174 YEVKVYTGDVIGAGTDADVFINIFGEYGDTGERRL-ENEKDNFEKGAEDRFILDA-PDLG 231
Y ++VYTG A T A V I ++G G + L + +K FE+G D F+L LG
Sbjct: 745 YLIQVYTGYRRSAATTAKVVITLYGSEGRSEPHHLCDPQKTVFERGGLDVFLLTTWTSLG 804
Query: 232 QLMKINVGHNNKGGSAGWFLSQIVIEDIGNKRKYDFPLNRWLALDEDDGKIQR 284
L + + H+N G S W++SQ+++ D+ KRK+ F N WLA+D D ++ R
Sbjct: 805 NLHSLRLWHDNSGVSPSWYVSQVIVCDMAVKRKWHFLCNCWLAVDLGDCELDR 857
Score = 73.2 bits (178), Expect = 3e-12
Identities = 41/117 (35%), Positives = 65/117 (55%), Gaps = 3/117 (2%)
Query: 1462 YSVQIFTGNIPGAGTDAKVYITIYGDLGDTGERYLGKSENRTNKFERGTADTFIIEA-AD 1520
Y +Q++TG A T AKV IT+YG G + +L + + FERG D F++
Sbjct: 745 YLIQVYTGYRRSAATTAKVVITLYGSEGRSEPHHL--CDPQKTVFERGGLDVFLLTTWTS 802
Query: 1521 LGVIYKIKLRHDNSKWCADWYVEKVEIWNDTNEDEFLFLCGRWLSLKKEDGRLERLF 1577
LG ++ ++L HDNS WYV +V + + + ++ FLC WL++ D L+R+F
Sbjct: 803 LGNLHSLRLWHDNSGVSPSWYVSQVIVCDMAVKRKWHFLCNCWLAVDLGDCELDRVF 859
Score = 70.9 bits (172), Expect = 1e-11
Identities = 43/122 (35%), Positives = 65/122 (53%), Gaps = 3/122 (2%)
Query: 1024 YEVQVVTGNVPKAGTDANVYLTIYGEEYGDTGERPLKKSDKSNKFEQGQTDTFTIYA-ID 1082
Y +QV TG A T A V +T+YG E G + L K+ FE+G D F +
Sbjct: 745 YLIQVYTGYRRSAATTAKVVITLYGSE-GRSEPHHLCDPQKT-VFERGGLDVFLLTTWTS 802
Query: 1083 LGALTKIRIRHDNTGNRAGWFLDRIDITDMNNEITYYFPCQRWLAVEEDDGQLSRELLPV 1142
LG L +R+ HDN+G W++ ++ + DM + ++F C WLAV+ D +L R +PV
Sbjct: 803 LGNLHSLRLWHDNSGVSPSWYVSQVIVCDMAVKRKWHFLCNCWLAVDLGDCELDRVFIPV 862
Query: 1143 DE 1144
+
Sbjct: 863 SK 864
Score = 69.3 bits (168), Expect = 4e-11
Identities = 40/108 (37%), Positives = 53/108 (49%), Gaps = 1/108 (0%)
Query: 2094 YEVIVTTGYEPGAGTDANVFVTIFGANGDTGKRELKQKMRNLFERGSTDRFFLET-LELG 2152
Y + V TGY A T A V +T++G+ G + L + +FERG D F L T LG
Sbjct: 745 YLIQVYTGYRRSAATTAKVVITLYGSEGRSEPHHLCDPQKTVFERGGLDVFLLTTWTSLG 804
Query: 2153 ELRKVRLEHDSSGYCSGWLVEKVEVTNTSTGVATIFNCGRWLDKKRGD 2200
L +RL HD+SG W V +V V + + F C WL GD
Sbjct: 805 NLHSLRLWHDNSGVSPSWYVSQVIVCDMAVKRKWHFLCNCWLAVDLGD 852
Score = 63.2 bits (152), Expect = 3e-09
Identities = 46/156 (29%), Positives = 78/156 (50%), Gaps = 5/156 (3%)
Query: 661 KDKDDGQLVRELLPSDSSATLKNFRYHISLKTGDVSGASTDSRVYIKLYGDKSDTIKQVL 720
KD+ D Q V+ + +D+ + + F Y I + TG A+T ++V I LYG + + L
Sbjct: 721 KDQADMQKVKVTVLADNDPSAQ-FHYLIQVYTGYRRSAATTAKVVITLYGSEGRSEPHHL 779
Query: 721 LVSDNNLKDYFERGRVDEFTLET-LNIGNINRLVIGHDSTGMHASWFLGSVQIRVPRQGK 779
+ K FERG +D F L T ++GN++ L + HD++G+ SW++ V + +
Sbjct: 780 C---DPQKTVFERGGLDVFLLTTWTSLGNLHSLRLWHDNSGVSPSWYVSQVIVCDMAVKR 836
Query: 780 QYTFPANRWLDKNQADGRLEVELYPSEVVEIQKLVH 815
++ F N WL + D L+ P E+ H
Sbjct: 837 KWHFLCNCWLAVDLGDCELDRVFIPVSKRELFSFRH 872
Score = 62.0 bits (149), Expect = 6e-09
Identities = 44/127 (34%), Positives = 66/127 (51%), Gaps = 7/127 (5%)
Query: 1168 LEQKDKSTTFSVTIK--TGVKKNAGTDANVFITLFGTQDDTGMT-LLKSSKTNSDKFERD 1224
L D S F I+ TG +++A T A V ITL+G++ + L KT FER
Sbjct: 734 LADNDPSAQFHYLIQVYTGYRRSAATTAKVVITLYGSEGRSEPHHLCDPQKT---VFERG 790
Query: 1225 SIEIFTVET-LDLGDLWKVRLGHDNTGKAPGWFVDWVEVDAPSLGKCMTFPCGRWLAKNE 1283
+++F + T LG+L +RL HDN+G +P W+V V V ++ + F C WLA +
Sbjct: 791 GLDVFLLTTWTSLGNLHSLRLWHDNSGVSPSWYVSQVIVCDMAVKRKWHFLCNCWLAVDL 850
Query: 1284 DDGSIIR 1290
D + R
Sbjct: 851 GDCELDR 857
Score = 61.6 bits (148), Expect = 8e-09
Identities = 33/92 (35%), Positives = 51/92 (55%), Gaps = 2/92 (2%)
Query: 815 HYEVEIWTGDVGGAGTSARVYMQIYGEKGKTEVLFLSSRSK-VFERASKDTFQLEA-ADV 872
HY ++++TG A T+A+V + +YG +G++E L K VFER D F L +
Sbjct: 744 HYLIQVYTGYRRSAATTAKVVITLYGSEGRSEPHHLCDPQKTVFERGGLDVFLLTTWTSL 803
Query: 873 GEVYKLRLGHTGEGFGPSWFVDTVWLRHLVVR 904
G ++ LRL H G PSW+V V + + V+
Sbjct: 804 GNLHSLRLWHDNSGVSPSWYVSQVIVCDMAVK 835
Score = 61.2 bits (147), Expect = 1e-08
Identities = 32/116 (27%), Positives = 61/116 (52%), Gaps = 2/116 (1%)
Query: 424 KFPWSLWVWTTDLKKAGTNSPIFIQIYGQKGRTD-EILLNPNNKWFKPGIIEKFRIEL-P 481
+F + + V+T + A T + + I +YG +GR++ L +P F+ G ++ F +
Sbjct: 742 QFHYLIQVYTGYRRSAATTAKVVITLYGSEGRSEPHHLCDPQKTVFERGGLDVFLLTTWT 801
Query: 482 DLGRFYKIRVWHDKRSSGSGWHLERMTLMNTLNKDKYNFNCNRWLDANEDDNEIVR 537
LG + +R+WHD W++ ++ + + K K++F CN WL + D E+ R
Sbjct: 802 SLGNLHSLRLWHDNSGVSPSWYVSQVIVCDMAVKRKWHFLCNCWLAVDLGDCELDR 857
Score = 58.2 bits (139), Expect = 9e-08
Identities = 34/133 (25%), Positives = 62/133 (46%), Gaps = 1/133 (0%)
Query: 278 DDGKIQRDILVGGAETTAITYIVTVFTGDVRGAGTKSKIYLVMYGARGNKNSGKIF-LEG 336
D K++ +L + Y++ V+TG R A T +K+ + +YG+ G + +
Sbjct: 725 DMQKVKVTVLADNDPSAQFHYLIQVYTGYRRSAATTAKVVITLYGSEGRSEPHHLCDPQK 784
Query: 337 GVFDRGRTDIFHIELAVLLSPLSRVSVGHGNVGVNRGWFCEKVVILCPFTGIQQTFPCSN 396
VF+RG D+F + L L + + H N GV+ W+ +V++ + F C+
Sbjct: 785 TVFERGGLDVFLLTTWTSLGNLHSLRLWHDNSGVSPSWYVSQVIVCDMAVKRKWHFLCNC 844
Query: 397 WLDEKKADGLIER 409
WL D ++R
Sbjct: 845 WLAVDLGDCELDR 857
Score = 55.8 bits (133), Expect = 4e-07
Identities = 42/136 (30%), Positives = 62/136 (45%), Gaps = 6/136 (4%)
Query: 555 YHVTVCTGELEGAGTDANVYLCLFGDVGDTGERLLYNCRNNTDLFEKGNADEFTIESVT- 613
Y + V TG A T A V + L+G G + L C +FE+G D F + + T
Sbjct: 745 YLIQVYTGYRRSAATTAKVVITLYGSEGRSEPHHL--CDPQKTVFERGGLDVFLLTTWTS 802
Query: 614 MRNVRRVRIRHDGKGSGSGWYLDRVLVREEGQPESDNVEFPCLRWLDKDKDDGQLVRELL 673
+ N+ +R+ HD G WY+ +V+V + F C WL D D +L R +
Sbjct: 803 LGNLHSLRLWHDNSGVSPSWYVSQVIVCD--MAVKRKWHFLCNCWLAVDLGDCELDRVFI 860
Query: 674 PSDSSATLKNFRYHIS 689
P S L +FR+ S
Sbjct: 861 PV-SKRELFSFRHLFS 875
Score = 49.7 bits (117), Expect = 3e-05
Identities = 35/125 (28%), Positives = 58/125 (46%), Gaps = 8/125 (6%)
Query: 1308 YEITLYTSDVFAAGTDANIFIIIYGCDAVCTQQKYLCTNKREQKQFFERKSASRFIVELE 1367
Y I +YT +A T A + I +YG + ++ +LC QK FER F++
Sbjct: 745 YLIQVYTGYRRSAATTAKVVITLYGSEGR-SEPHHLCD---PQKTVFERGGLDVFLLTTW 800
Query: 1368 DVGEIIEKIRIGHNNTGMNPGWHCSHVDIRRLLPDKDGAETLTFPCDRWLATSEDDKKTI 1427
+ +R+ H+N+G++P W+ S V ++ D F C+ WLA D +
Sbjct: 801 TSLGNLHSLRLWHDNSGVSPSWYVSQV----IVCDMAVKRKWHFLCNCWLAVDLGDCELD 856
Query: 1428 RELVP 1432
R +P
Sbjct: 857 RVFIP 861
Score = 43.9 bits (102), Expect = 0.002
Identities = 28/103 (27%), Positives = 48/103 (46%), Gaps = 2/103 (1%)
Query: 1698 YEMTVWTGDVVGGGTDSNIFMTLYGINGSTEEMQL-DKKKARFEREQNDTFIMEI-LDIA 1755
Y + V+TG T + + +TLYG G +E L D +K FER D F++ +
Sbjct: 745 YLIQVYTGYRRSAATTAKVVITLYGSEGRSEPHHLCDPQKTVFERGGLDVFLLTTWTSLG 804
Query: 1756 PFTKMRIRIDGLGSRPEWFLERILLKNMNTGDLTMFYYGDWLS 1798
+R+ D G P W++ ++++ +M F WL+
Sbjct: 805 NLHSLRLWHDNSGVSPSWYVSQVIVCDMAVKRKWHFLCNCWLA 847
>gi|31559825 polycystin 1-like 3 [Homo sapiens]
Length = 1732
Score = 81.3 bits (199), Expect = 1e-14
Identities = 46/111 (41%), Positives = 66/111 (59%), Gaps = 6/111 (5%)
Query: 45 YEVVTATGDVRGAGTDANVFITLFGENGLSPKLQLTSKSKSAFEKGNVDVFRVRT-NNVG 103
Y + TG R A T A V ITL+G G S L K+ FE+G +DVF + T ++G
Sbjct: 745 YLIQVYTGYRRSAATTAKVVITLYGSEGRSEPHHLCDPQKTVFERGGLDVFLLTTWTSLG 804
Query: 104 LIYKVRIEHDNTGLNASWYLDHVIVTDM--KRPHLRYYFNCNNWLSKVEGD 152
++ +R+ HDN+G++ SWY+ VIV DM KR +++F CN WL+ GD
Sbjct: 805 NLHSLRLWHDNSGVSPSWYVSQVIVCDMAVKR---KWHFLCNCWLAVDLGD 852
Score = 79.0 bits (193), Expect = 5e-14
Identities = 49/155 (31%), Positives = 71/155 (45%), Gaps = 5/155 (3%)
Query: 1825 YTVAVKTSDILGAGTDANVFIIIFGENGDSGTLALKQSANWNKFERNNTDTFNFPDMLSL 1884
Y + V T A T A V I ++G G S L FER D F SL
Sbjct: 745 YLIQVYTGYRRSAATTAKVVITLYGSEGRSEPHHLCDPQK-TVFERGGLDVFLLTTWTSL 803
Query: 1885 GHLCKLRVWHDNKGIFPGWHLSYVDVKDNSRDETFHFQCDCWLSKSEGDGQTVRDFACAN 1944
G+L LR+WHDN G+ P W++S V V D + +HF C+CWL+ GD + R F +
Sbjct: 804 GNLHSLRLWHDNSGVSPSWYVSQVIVCDMAVKRKWHFLCNCWLAVDLGDCELDRVFIPVS 863
Query: 1945 NKICDELEETTYEIVIETGNGGETRENVWLILEGR 1979
+ +++E T++ +WL + R
Sbjct: 864 KRELFSFRHLFSSMIVEK----FTQDYLWLSIATR 894
Score = 75.1 bits (183), Expect = 7e-13
Identities = 42/113 (37%), Positives = 64/113 (56%), Gaps = 2/113 (1%)
Query: 174 YEVKVYTGDVIGAGTDADVFINIFGEYGDTGERRL-ENEKDNFEKGAEDRFILDA-PDLG 231
Y ++VYTG A T A V I ++G G + L + +K FE+G D F+L LG
Sbjct: 745 YLIQVYTGYRRSAATTAKVVITLYGSEGRSEPHHLCDPQKTVFERGGLDVFLLTTWTSLG 804
Query: 232 QLMKINVGHNNKGGSAGWFLSQIVIEDIGNKRKYDFPLNRWLALDEDDGKIQR 284
L + + H+N G S W++SQ+++ D+ KRK+ F N WLA+D D ++ R
Sbjct: 805 NLHSLRLWHDNSGVSPSWYVSQVIVCDMAVKRKWHFLCNCWLAVDLGDCELDR 857
Score = 73.2 bits (178), Expect = 3e-12
Identities = 41/117 (35%), Positives = 65/117 (55%), Gaps = 3/117 (2%)
Query: 1462 YSVQIFTGNIPGAGTDAKVYITIYGDLGDTGERYLGKSENRTNKFERGTADTFIIEA-AD 1520
Y +Q++TG A T AKV IT+YG G + +L + + FERG D F++
Sbjct: 745 YLIQVYTGYRRSAATTAKVVITLYGSEGRSEPHHL--CDPQKTVFERGGLDVFLLTTWTS 802
Query: 1521 LGVIYKIKLRHDNSKWCADWYVEKVEIWNDTNEDEFLFLCGRWLSLKKEDGRLERLF 1577
LG ++ ++L HDNS WYV +V + + + ++ FLC WL++ D L+R+F
Sbjct: 803 LGNLHSLRLWHDNSGVSPSWYVSQVIVCDMAVKRKWHFLCNCWLAVDLGDCELDRVF 859
Score = 70.9 bits (172), Expect = 1e-11
Identities = 43/122 (35%), Positives = 65/122 (53%), Gaps = 3/122 (2%)
Query: 1024 YEVQVVTGNVPKAGTDANVYLTIYGEEYGDTGERPLKKSDKSNKFEQGQTDTFTIYA-ID 1082
Y +QV TG A T A V +T+YG E G + L K+ FE+G D F +
Sbjct: 745 YLIQVYTGYRRSAATTAKVVITLYGSE-GRSEPHHLCDPQKT-VFERGGLDVFLLTTWTS 802
Query: 1083 LGALTKIRIRHDNTGNRAGWFLDRIDITDMNNEITYYFPCQRWLAVEEDDGQLSRELLPV 1142
LG L +R+ HDN+G W++ ++ + DM + ++F C WLAV+ D +L R +PV
Sbjct: 803 LGNLHSLRLWHDNSGVSPSWYVSQVIVCDMAVKRKWHFLCNCWLAVDLGDCELDRVFIPV 862
Query: 1143 DE 1144
+
Sbjct: 863 SK 864
Score = 69.3 bits (168), Expect = 4e-11
Identities = 40/108 (37%), Positives = 53/108 (49%), Gaps = 1/108 (0%)
Query: 2094 YEVIVTTGYEPGAGTDANVFVTIFGANGDTGKRELKQKMRNLFERGSTDRFFLET-LELG 2152
Y + V TGY A T A V +T++G+ G + L + +FERG D F L T LG
Sbjct: 745 YLIQVYTGYRRSAATTAKVVITLYGSEGRSEPHHLCDPQKTVFERGGLDVFLLTTWTSLG 804
Query: 2153 ELRKVRLEHDSSGYCSGWLVEKVEVTNTSTGVATIFNCGRWLDKKRGD 2200
L +RL HD+SG W V +V V + + F C WL GD
Sbjct: 805 NLHSLRLWHDNSGVSPSWYVSQVIVCDMAVKRKWHFLCNCWLAVDLGD 852
Score = 63.2 bits (152), Expect = 3e-09
Identities = 46/156 (29%), Positives = 78/156 (50%), Gaps = 5/156 (3%)
Query: 661 KDKDDGQLVRELLPSDSSATLKNFRYHISLKTGDVSGASTDSRVYIKLYGDKSDTIKQVL 720
KD+ D Q V+ + +D+ + + F Y I + TG A+T ++V I LYG + + L
Sbjct: 721 KDQADMQKVKVTVLADNDPSAQ-FHYLIQVYTGYRRSAATTAKVVITLYGSEGRSEPHHL 779
Query: 721 LVSDNNLKDYFERGRVDEFTLET-LNIGNINRLVIGHDSTGMHASWFLGSVQIRVPRQGK 779
+ K FERG +D F L T ++GN++ L + HD++G+ SW++ V + +
Sbjct: 780 C---DPQKTVFERGGLDVFLLTTWTSLGNLHSLRLWHDNSGVSPSWYVSQVIVCDMAVKR 836
Query: 780 QYTFPANRWLDKNQADGRLEVELYPSEVVEIQKLVH 815
++ F N WL + D L+ P E+ H
Sbjct: 837 KWHFLCNCWLAVDLGDCELDRVFIPVSKRELFSFRH 872
Score = 62.0 bits (149), Expect = 6e-09
Identities = 44/127 (34%), Positives = 66/127 (51%), Gaps = 7/127 (5%)
Query: 1168 LEQKDKSTTFSVTIK--TGVKKNAGTDANVFITLFGTQDDTGMT-LLKSSKTNSDKFERD 1224
L D S F I+ TG +++A T A V ITL+G++ + L KT FER
Sbjct: 734 LADNDPSAQFHYLIQVYTGYRRSAATTAKVVITLYGSEGRSEPHHLCDPQKT---VFERG 790
Query: 1225 SIEIFTVET-LDLGDLWKVRLGHDNTGKAPGWFVDWVEVDAPSLGKCMTFPCGRWLAKNE 1283
+++F + T LG+L +RL HDN+G +P W+V V V ++ + F C WLA +
Sbjct: 791 GLDVFLLTTWTSLGNLHSLRLWHDNSGVSPSWYVSQVIVCDMAVKRKWHFLCNCWLAVDL 850
Query: 1284 DDGSIIR 1290
D + R
Sbjct: 851 GDCELDR 857
Score = 61.6 bits (148), Expect = 8e-09
Identities = 33/92 (35%), Positives = 51/92 (55%), Gaps = 2/92 (2%)
Query: 815 HYEVEIWTGDVGGAGTSARVYMQIYGEKGKTEVLFLSSRSK-VFERASKDTFQLEA-ADV 872
HY ++++TG A T+A+V + +YG +G++E L K VFER D F L +
Sbjct: 744 HYLIQVYTGYRRSAATTAKVVITLYGSEGRSEPHHLCDPQKTVFERGGLDVFLLTTWTSL 803
Query: 873 GEVYKLRLGHTGEGFGPSWFVDTVWLRHLVVR 904
G ++ LRL H G PSW+V V + + V+
Sbjct: 804 GNLHSLRLWHDNSGVSPSWYVSQVIVCDMAVK 835
Score = 61.2 bits (147), Expect = 1e-08
Identities = 32/116 (27%), Positives = 61/116 (52%), Gaps = 2/116 (1%)
Query: 424 KFPWSLWVWTTDLKKAGTNSPIFIQIYGQKGRTD-EILLNPNNKWFKPGIIEKFRIEL-P 481
+F + + V+T + A T + + I +YG +GR++ L +P F+ G ++ F +
Sbjct: 742 QFHYLIQVYTGYRRSAATTAKVVITLYGSEGRSEPHHLCDPQKTVFERGGLDVFLLTTWT 801
Query: 482 DLGRFYKIRVWHDKRSSGSGWHLERMTLMNTLNKDKYNFNCNRWLDANEDDNEIVR 537
LG + +R+WHD W++ ++ + + K K++F CN WL + D E+ R
Sbjct: 802 SLGNLHSLRLWHDNSGVSPSWYVSQVIVCDMAVKRKWHFLCNCWLAVDLGDCELDR 857
Score = 58.2 bits (139), Expect = 9e-08
Identities = 34/133 (25%), Positives = 62/133 (46%), Gaps = 1/133 (0%)
Query: 278 DDGKIQRDILVGGAETTAITYIVTVFTGDVRGAGTKSKIYLVMYGARGNKNSGKIF-LEG 336
D K++ +L + Y++ V+TG R A T +K+ + +YG+ G + +
Sbjct: 725 DMQKVKVTVLADNDPSAQFHYLIQVYTGYRRSAATTAKVVITLYGSEGRSEPHHLCDPQK 784
Query: 337 GVFDRGRTDIFHIELAVLLSPLSRVSVGHGNVGVNRGWFCEKVVILCPFTGIQQTFPCSN 396
VF+RG D+F + L L + + H N GV+ W+ +V++ + F C+
Sbjct: 785 TVFERGGLDVFLLTTWTSLGNLHSLRLWHDNSGVSPSWYVSQVIVCDMAVKRKWHFLCNC 844
Query: 397 WLDEKKADGLIER 409
WL D ++R
Sbjct: 845 WLAVDLGDCELDR 857
Score = 55.8 bits (133), Expect = 4e-07
Identities = 42/136 (30%), Positives = 62/136 (45%), Gaps = 6/136 (4%)
Query: 555 YHVTVCTGELEGAGTDANVYLCLFGDVGDTGERLLYNCRNNTDLFEKGNADEFTIESVT- 613
Y + V TG A T A V + L+G G + L C +FE+G D F + + T
Sbjct: 745 YLIQVYTGYRRSAATTAKVVITLYGSEGRSEPHHL--CDPQKTVFERGGLDVFLLTTWTS 802
Query: 614 MRNVRRVRIRHDGKGSGSGWYLDRVLVREEGQPESDNVEFPCLRWLDKDKDDGQLVRELL 673
+ N+ +R+ HD G WY+ +V+V + F C WL D D +L R +
Sbjct: 803 LGNLHSLRLWHDNSGVSPSWYVSQVIVCD--MAVKRKWHFLCNCWLAVDLGDCELDRVFI 860
Query: 674 PSDSSATLKNFRYHIS 689
P S L +FR+ S
Sbjct: 861 PV-SKRELFSFRHLFS 875
Score = 49.7 bits (117), Expect = 3e-05
Identities = 35/125 (28%), Positives = 58/125 (46%), Gaps = 8/125 (6%)
Query: 1308 YEITLYTSDVFAAGTDANIFIIIYGCDAVCTQQKYLCTNKREQKQFFERKSASRFIVELE 1367
Y I +YT +A T A + I +YG + ++ +LC QK FER F++
Sbjct: 745 YLIQVYTGYRRSAATTAKVVITLYGSEGR-SEPHHLCD---PQKTVFERGGLDVFLLTTW 800
Query: 1368 DVGEIIEKIRIGHNNTGMNPGWHCSHVDIRRLLPDKDGAETLTFPCDRWLATSEDDKKTI 1427
+ +R+ H+N+G++P W+ S V ++ D F C+ WLA D +
Sbjct: 801 TSLGNLHSLRLWHDNSGVSPSWYVSQV----IVCDMAVKRKWHFLCNCWLAVDLGDCELD 856
Query: 1428 RELVP 1432
R +P
Sbjct: 857 RVFIP 861
Score = 43.9 bits (102), Expect = 0.002
Identities = 28/103 (27%), Positives = 48/103 (46%), Gaps = 2/103 (1%)
Query: 1698 YEMTVWTGDVVGGGTDSNIFMTLYGINGSTEEMQL-DKKKARFEREQNDTFIMEI-LDIA 1755
Y + V+TG T + + +TLYG G +E L D +K FER D F++ +
Sbjct: 745 YLIQVYTGYRRSAATTAKVVITLYGSEGRSEPHHLCDPQKTVFERGGLDVFLLTTWTSLG 804
Query: 1756 PFTKMRIRIDGLGSRPEWFLERILLKNMNTGDLTMFYYGDWLS 1798
+R+ D G P W++ ++++ +M F WL+
Sbjct: 805 NLHSLRLWHDNSGVSPSWYVSQVIVCDMAVKRKWHFLCNCWLA 847
>gi|19923084 polycystin-1L1 [Homo sapiens]
Length = 2849
Score = 79.3 bits (194), Expect = 4e-14
Identities = 43/118 (36%), Positives = 61/118 (51%), Gaps = 1/118 (0%)
Query: 1825 YTVAVKTSDILGAGTDANVFIIIFGENGDSGTLALKQSANWNKFERNNTDTFNFPDMLSL 1884
Y V + T A + V+I++ G+NG S T L FERN+ TF L
Sbjct: 1798 YAVVIDTGFRAPARLTSKVYIVLCGDNGLSETKELSCPEK-PLFERNSRHTFILSAPAQL 1856
Query: 1885 GHLCKLRVWHDNKGIFPGWHLSYVDVKDNSRDETFHFQCDCWLSKSEGDGQTVRDFAC 1942
G L K+R+WHD++G PGW +S+V VK+ + + F CWLS DG+ R+ C
Sbjct: 1857 GLLRKIRLWHDSRGPSPGWFISHVMVKELHTGQGWFFPAQCWLSAGRHDGRVERELTC 1914
Score = 74.3 bits (181), Expect = 1e-12
Identities = 43/115 (37%), Positives = 57/115 (49%), Gaps = 1/115 (0%)
Query: 2094 YEVIVTTGYEPGAGTDANVFVTIFGANGDTGKRELKQKMRNLFERGSTDRFFLET-LELG 2152
Y V++ TG+ A + V++ + G NG + +EL + LFER S F L +LG
Sbjct: 1798 YAVVIDTGFRAPARLTSKVYIVLCGDNGLSETKELSCPEKPLFERNSRHTFILSAPAQLG 1857
Query: 2153 ELRKVRLEHDSSGYCSGWLVEKVEVTNTSTGVATIFNCGRWLDKKRGDGLTWRDL 2207
LRK+RL HDS G GW + V V TG F WL R DG R+L
Sbjct: 1858 LLRKIRLWHDSRGPSPGWFISHVMVKELHTGQGWFFPAQCWLSAGRHDGRVEREL 1912
Score = 71.6 bits (174), Expect = 8e-12
Identities = 42/127 (33%), Positives = 71/127 (55%), Gaps = 4/127 (3%)
Query: 168 MPRGNKYEVKVYTGDVIGAGTDADVFINIFGEYGDTGERRLE-NEKDNFEKGAEDRFILD 226
+P Y V + TG A + V+I + G+ G + + L EK FE+ + FIL
Sbjct: 1792 LPGHQLYAVVIDTGFRAPARLTSKVYIVLCGDNGLSETKELSCPEKPLFERNSRHTFILS 1851
Query: 227 AP-DLGQLMKINVGHNNKGGSAGWFLSQIVIEDIGNKRKYDFPLNRWLALDEDDGKIQRD 285
AP LG L KI + H+++G S GWF+S ++++++ + + FP WL+ DG+++R+
Sbjct: 1852 APAQLGLLRKIRLWHDSRGPSPGWFISHVMVKELHTGQGWFFPAQCWLSAGRHDGRVERE 1911
Query: 286 I--LVGG 290
+ L GG
Sbjct: 1912 LTCLQGG 1918
Score = 64.7 bits (156), Expect = 1e-09
Identities = 39/122 (31%), Positives = 62/122 (50%), Gaps = 3/122 (2%)
Query: 1019 PERNTYEVQVVTGNVPKAGTDANVYLTIYGEEYGDTGERPLKKSDKSNKFEQGQTDTFTI 1078
P Y V + TG A + VY+ + G+ G + + L +K FE+ TF +
Sbjct: 1793 PGHQLYAVVIDTGFRAPARLTSKVYIVLCGDN-GLSETKELSCPEKP-LFERNSRHTFIL 1850
Query: 1079 YA-IDLGALTKIRIRHDNTGNRAGWFLDRIDITDMNNEITYYFPCQRWLAVEEDDGQLSR 1137
A LG L KIR+ HD+ G GWF+ + + +++ ++FP Q WL+ DG++ R
Sbjct: 1851 SAPAQLGLLRKIRLWHDSRGPSPGWFISHVMVKELHTGQGWFFPAQCWLSAGRHDGRVER 1910
Query: 1138 EL 1139
EL
Sbjct: 1911 EL 1912
Score = 63.9 bits (154), Expect = 2e-09
Identities = 42/118 (35%), Positives = 59/118 (50%), Gaps = 5/118 (4%)
Query: 1177 FSVTIKTGVKKNAGTDANVFITLFGTQDDTGMTLLKS-SKTNSDKFERDSIEIFTVET-L 1234
++V I TG + A + V+I L G D G++ K S FER+S F +
Sbjct: 1798 YAVVIDTGFRAPARLTSKVYIVLCG---DNGLSETKELSCPEKPLFERNSRHTFILSAPA 1854
Query: 1235 DLGDLWKVRLGHDNTGKAPGWFVDWVEVDAPSLGKCMTFPCGRWLAKNEDDGSIIRDL 1292
LG L K+RL HD+ G +PGWF+ V V G+ FP WL+ DG + R+L
Sbjct: 1855 QLGLLRKIRLWHDSRGPSPGWFISHVMVKELHTGQGWFFPAQCWLSAGRHDGRVEREL 1912
Score = 60.8 bits (146), Expect = 1e-08
Identities = 37/118 (31%), Positives = 62/118 (52%), Gaps = 2/118 (1%)
Query: 43 RVYEVVTATGDVRGAGTDANVFITLFGENGLSPKLQLTSKSKSAFEKGNVDVFRVRT-NN 101
++Y VV TG A + V+I L G+NGLS +L+ K FE+ + F +
Sbjct: 1796 QLYAVVIDTGFRAPARLTSKVYIVLCGDNGLSETKELSCPEKPLFERNSRHTFILSAPAQ 1855
Query: 102 VGLIYKVRIEHDNTGLNASWYLDHVIVTDMKRPHLRYYFNCNNWLSKVEGDRQWCRDL 159
+GL+ K+R+ HD+ G + W++ HV+V ++ ++F WLS D + R+L
Sbjct: 1856 LGLLRKIRLWHDSRGPSPGWFISHVMVKELHTGQ-GWFFPAQCWLSAGRHDGRVEREL 1912
Score = 60.5 bits (145), Expect = 2e-08
Identities = 42/116 (36%), Positives = 59/116 (50%), Gaps = 3/116 (2%)
Query: 1461 LYSVQIFTGNIPGAGTDAKVYITIYGDLGDTGERYLGKSENRTNKFERGTADTFIIEA-A 1519
LY+V I TG A +KVYI + GD G + + L E FER + TFI+ A A
Sbjct: 1797 LYAVVIDTGFRAPARLTSKVYIVLCGDNGLSETKELSCPEKPL--FERNSRHTFILSAPA 1854
Query: 1520 DLGVIYKIKLRHDNSKWCADWYVEKVEIWNDTNEDEFLFLCGRWLSLKKEDGRLER 1575
LG++ KI+L HD+ W++ V + + F WLS + DGR+ER
Sbjct: 1855 QLGLLRKIRLWHDSRGPSPGWFISHVMVKELHTGQGWFFPAQCWLSAGRHDGRVER 1910
Score = 59.7 bits (143), Expect = 3e-08
Identities = 38/118 (32%), Positives = 57/118 (48%), Gaps = 4/118 (3%)
Query: 686 YHISLKTGDVSGASTDSRVYIKLYGDKSDTIKQVLLVSDNNLKDYFERGRVDEFTLET-L 744
Y + + TG + A S+VYI L GD + + L + K FER F L
Sbjct: 1798 YAVVIDTGFRAPARLTSKVYIVLCGDNGLSETKELSCPE---KPLFERNSRHTFILSAPA 1854
Query: 745 NIGNINRLVIGHDSTGMHASWFLGSVQIRVPRQGKQYTFPANRWLDKNQADGRLEVEL 802
+G + ++ + HDS G WF+ V ++ G+ + FPA WL + DGR+E EL
Sbjct: 1855 QLGLLRKIRLWHDSRGPSPGWFISHVMVKELHTGQGWFFPAQCWLSAGRHDGRVEREL 1912
Score = 54.7 bits (130), Expect = 1e-06
Identities = 34/115 (29%), Positives = 54/115 (46%), Gaps = 1/115 (0%)
Query: 298 YIVTVFTGDVRGAGTKSKIYLVMYGARGNKNSGKIFL-EGGVFDRGRTDIFHIELAVLLS 356
Y V + TG A SK+Y+V+ G G + ++ E +F+R F + L
Sbjct: 1798 YAVVIDTGFRAPARLTSKVYIVLCGDNGLSETKELSCPEKPLFERNSRHTFILSAPAQLG 1857
Query: 357 PLSRVSVGHGNVGVNRGWFCEKVVILCPFTGIQQTFPCSNWLDEKKADGLIERQL 411
L ++ + H + G + GWF V++ TG FP WL + DG +ER+L
Sbjct: 1858 LLRKIRLWHDSRGPSPGWFISHVMVKELHTGQGWFFPAQCWLSAGRHDGRVEREL 1912
Score = 54.7 bits (130), Expect = 1e-06
Identities = 33/123 (26%), Positives = 57/123 (46%), Gaps = 8/123 (6%)
Query: 1308 YEITLYTSDVFAAGTDANIFIIIYGCDAVCTQQKYLCTNKREQKQFFERKSASRFIVELE 1367
Y + + T A + ++I++ G + + ++ C +K FER S FI+
Sbjct: 1798 YAVVIDTGFRAPARLTSKVYIVLCGDNGLSETKELSCP----EKPLFERNSRHTFILSAP 1853
Query: 1368 DVGEIIEKIRIGHNNTGMNPGWHCSHVDIRRLLPDKDGAETLTFPCDRWLATSEDDKKTI 1427
++ KIR+ H++ G +PGW SHV ++ L + FP WL+ D +
Sbjct: 1854 AQLGLLRKIRLWHDSRGPSPGWFISHVMVKEL----HTGQGWFFPAQCWLSAGRHDGRVE 1909
Query: 1428 REL 1430
REL
Sbjct: 1910 REL 1912
Score = 53.9 bits (128), Expect = 2e-06
Identities = 37/123 (30%), Positives = 59/123 (47%), Gaps = 5/123 (4%)
Query: 551 GMARYHVTVCTGELEGAGTDANVYLCLFGDVGDTGERLLYNCRNNTDLFEKGNADEFTIE 610
G Y V + TG A + VY+ L GD G + + L +C LFE+ + F +
Sbjct: 1794 GHQLYAVVIDTGFRAPARLTSKVYIVLCGDNGLSETKEL-SCPEKP-LFERNSRHTFILS 1851
Query: 611 SVTMRNV-RRVRIRHDGKGSGSGWYLDRVLVREEGQPESDNVEFPCLRWLDKDKDDGQLV 669
+ + R++R+ HD +G GW++ V+V+E FP WL + DG++
Sbjct: 1852 APAQLGLLRKIRLWHDSRGPSPGWFISHVMVKE--LHTGQGWFFPAQCWLSAGRHDGRVE 1909
Query: 670 REL 672
REL
Sbjct: 1910 REL 1912
Score = 53.1 bits (126), Expect = 3e-06
Identities = 34/88 (38%), Positives = 49/88 (55%), Gaps = 2/88 (2%)
Query: 816 YEVEIWTGDVGGAGTSARVYMQIYGEKGKTEVLFLSSRSK-VFERASKDTFQLEA-ADVG 873
Y V I TG A +++VY+ + G+ G +E LS K +FER S+ TF L A A +G
Sbjct: 1798 YAVVIDTGFRAPARLTSKVYIVLCGDNGLSETKELSCPEKPLFERNSRHTFILSAPAQLG 1857
Query: 874 EVYKLRLGHTGEGFGPSWFVDTVWLRHL 901
+ K+RL H G P WF+ V ++ L
Sbjct: 1858 LLRKIRLWHDSRGPSPGWFISHVMVKEL 1885
Score = 52.4 bits (124), Expect = 5e-06
Identities = 32/104 (30%), Positives = 50/104 (48%), Gaps = 2/104 (1%)
Query: 1697 LYEMTVWTGDVVGGGTDSNIFMTLYGINGSTEEMQLD-KKKARFEREQNDTFIMEI-LDI 1754
LY + + TG S +++ L G NG +E +L +K FER TFI+ +
Sbjct: 1797 LYAVVIDTGFRAPARLTSKVYIVLCGDNGLSETKELSCPEKPLFERNSRHTFILSAPAQL 1856
Query: 1755 APFTKMRIRIDGLGSRPEWFLERILLKNMNTGDLTMFYYGDWLS 1798
K+R+ D G P WF+ +++K ++TG F WLS
Sbjct: 1857 GLLRKIRLWHDSRGPSPGWFISHVMVKELHTGQGWFFPAQCWLS 1900
Score = 48.5 bits (114), Expect = 7e-05
Identities = 29/104 (27%), Positives = 44/104 (42%), Gaps = 2/104 (1%)
Query: 439 AGTNSPIFIQIYGQKGRTDEILLN-PNNKWFKPGIIEKFRIELP-DLGRFYKIRVWHDKR 496
A S ++I + G G ++ L+ P F+ F + P LG KIR+WHD R
Sbjct: 1810 ARLTSKVYIVLCGDNGLSETKELSCPEKPLFERNSRHTFILSAPAQLGLLRKIRLWHDSR 1869
Query: 497 SSGSGWHLERMTLMNTLNKDKYNFNCNRWLDANEDDNEIVREMT 540
GW + + + + F WL A D + RE+T
Sbjct: 1870 GPSPGWFISHVMVKELHTGQGWFFPAQCWLSAGRHDGRVERELT 1913
>gi|205360962 polycystin 1 isoform 2 precursor [Homo sapiens]
Length = 4302
Score = 78.2 bits (191), Expect = 8e-14
Identities = 41/104 (39%), Positives = 66/104 (63%), Gaps = 4/104 (3%)
Query: 45 YEVVTATGDVRGAGTDANVFITLFGENGLSPKLQLTSKSKSAFEKGNVDVFRVRT-NNVG 103
YE++ TG RG+GT A+V I L+G + S L AF + ++D+FR+ T +++G
Sbjct: 3120 YEILVKTGWGRGSGTTAHVGIMLYGVDSRSGHRHLDGDR--AFHRNSLDIFRIATPHSLG 3177
Query: 104 LIYKVRIEHDNTGLNASWYLDHVIVTDMKRPHLRYYFNCNNWLS 147
++K+R+ HDN GL+ +W+L HVIV D++ +F N+WLS
Sbjct: 3178 SVWKIRVWHDNKGLSPAWFLQHVIVRDLQTAR-SAFFLVNDWLS 3220
Score = 75.1 bits (183), Expect = 7e-13
Identities = 52/161 (32%), Positives = 79/161 (49%), Gaps = 7/161 (4%)
Query: 1825 YTVAVKTSDILGAGTDANVFIIIFGENGDSGTLALKQSANWNKFERNNTDTFNFPDMLSL 1884
Y + VKT G+GT A+V I+++G + SG L F RN+ D F SL
Sbjct: 3120 YEILVKTGWGRGSGTTAHVGIMLYGVDSRSGHRHLDGD---RAFHRNSLDIFRIATPHSL 3176
Query: 1885 GHLCKLRVWHDNKGIFPGWHLSYVDVKDNSRDETFHFQCDCWLS-KSEGDGQTVRDFACA 1943
G + K+RVWHDNKG+ P W L +V V+D + F + WLS ++E +G V A
Sbjct: 3177 GSVWKIRVWHDNKGLSPAWFLQHVIVRDLQTARSAFFLVNDWLSVETEANGGLVEKEVLA 3236
Query: 1944 NNKICDELEETTYEIVIETGNGGETRENVWLILEGRKNRSK 1984
+ D +++ G +++WL + R RS+
Sbjct: 3237 AS---DAALLRFRRLLVAELQRGFFDKHIWLSIWDRPPRSR 3274
Score = 73.2 bits (178), Expect = 3e-12
Identities = 41/118 (34%), Positives = 68/118 (57%), Gaps = 4/118 (3%)
Query: 173 KYEVKVYTGDVIGAGTDADVFINIFGEYGDTGERRLENEKDNFEKGAEDRFILDAP-DLG 231
KYE+ V TG G+GT A V I ++G +G R L+ ++ F + + D F + P LG
Sbjct: 3119 KYEILVKTGWGRGSGTTAHVGIMLYGVDSRSGHRHLDGDRA-FHRNSLDIFRIATPHSLG 3177
Query: 232 QLMKINVGHNNKGGSAGWFLSQIVIEDIGNKRKYDFPLNRWLALDED--DGKIQRDIL 287
+ KI V H+NKG S WFL +++ D+ R F +N WL+++ + G +++++L
Sbjct: 3178 SVWKIRVWHDNKGLSPAWFLQHVIVRDLQTARSAFFLVNDWLSVETEANGGLVEKEVL 3235
Score = 66.2 bits (160), Expect = 3e-10
Identities = 37/115 (32%), Positives = 61/115 (53%), Gaps = 6/115 (5%)
Query: 1177 FSVTIKTGVKKNAGTDANVFITLFGTQDDTGMTLLKSSKTNSDKFERDSIEIFTVETL-D 1235
+ + +KTG + +GT A+V I L+G +G L + F R+S++IF + T
Sbjct: 3120 YEILVKTGWGRGSGTTAHVGIMLYGVDSRSGHRHLDGDRA----FHRNSLDIFRIATPHS 3175
Query: 1236 LGDLWKVRLGHDNTGKAPGWFVDWVEVDAPSLGKCMTFPCGRWLA-KNEDDGSII 1289
LG +WK+R+ HDN G +P WF+ V V + F WL+ + E +G ++
Sbjct: 3176 LGSVWKIRVWHDNKGLSPAWFLQHVIVRDLQTARSAFFLVNDWLSVETEANGGLV 3230
Score = 62.0 bits (149), Expect = 6e-09
Identities = 35/103 (33%), Positives = 54/103 (52%), Gaps = 3/103 (2%)
Query: 2093 KYEVIVTTGYEPGAGTDANVFVTIFGANGDTGKRELKQKMRNLFERGSTDRFFLET-LEL 2151
KYE++V TG+ G+GT A+V + ++G + +G R L F R S D F + T L
Sbjct: 3119 KYEILVKTGWGRGSGTTAHVGIMLYGVDSRSGHRHLDGD--RAFHRNSLDIFRIATPHSL 3176
Query: 2152 GELRKVRLEHDSSGYCSGWLVEKVEVTNTSTGVATIFNCGRWL 2194
G + K+R+ HD+ G W ++ V V + T + F WL
Sbjct: 3177 GSVWKIRVWHDNKGLSPAWFLQHVIVRDLQTARSAFFLVNDWL 3219
Score = 61.6 bits (148), Expect = 8e-09
Identities = 42/131 (32%), Positives = 66/131 (50%), Gaps = 7/131 (5%)
Query: 1021 RNTYEVQVVTGNVPKAGTDANVYLTIYGEEYGDTGERPLKKSDKSNKFEQGQTDTFTIYA 1080
R YE+ V TG +GT A+V + +YG + +G R L D F + D F I
Sbjct: 3117 RFKYEILVKTGWGRGSGTTAHVGIMLYGVD-SRSGHRHL---DGDRAFHRNSLDIFRIAT 3172
Query: 1081 I-DLGALTKIRIRHDNTGNRAGWFLDRIDITDMNNEITYYFPCQRWLAVEED--DGQLSR 1137
LG++ KIR+ HDN G WFL + + D+ + +F WL+VE + G + +
Sbjct: 3173 PHSLGSVWKIRVWHDNKGLSPAWFLQHVIVRDLQTARSAFFLVNDWLSVETEANGGLVEK 3232
Query: 1138 ELLPVDESYVL 1148
E+L ++ +L
Sbjct: 3233 EVLAASDAALL 3243
Score = 57.4 bits (137), Expect = 2e-07
Identities = 33/102 (32%), Positives = 52/102 (50%), Gaps = 2/102 (1%)
Query: 1698 YEMTVWTGDVVGGGTDSNIFMTLYGINGSTEEMQLDKKKARFEREQNDTF-IMEILDIAP 1756
YE+ V TG G GT +++ + LYG++ + LD +A F R D F I +
Sbjct: 3120 YEILVKTGWGRGSGTTAHVGIMLYGVDSRSGHRHLDGDRA-FHRNSLDIFRIATPHSLGS 3178
Query: 1757 FTKMRIRIDGLGSRPEWFLERILLKNMNTGDLTMFYYGDWLS 1798
K+R+ D G P WFL+ ++++++ T F DWLS
Sbjct: 3179 VWKIRVWHDNKGLSPAWFLQHVIVRDLQTARSAFFLVNDWLS 3220
Score = 55.5 bits (132), Expect = 6e-07
Identities = 45/161 (27%), Positives = 77/161 (47%), Gaps = 11/161 (6%)
Query: 551 GMARYHVTVCTGELEGAGTDANVYLCLFGDVGDTGERLLYNCRNNTDLFEKGNADEFTIE 610
G +Y + V TG G+GT A+V + L+G +G R L R F + + D F I
Sbjct: 3116 GRFKYEILVKTGWGRGSGTTAHVGIMLYGVDSRSGHRHLDGDR----AFHRNSLDIFRIA 3171
Query: 611 SV-TMRNVRRVRIRHDGKGSGSGWYLDRVLVREEGQPESDNVEFPCLRWLDKDKD-DGQL 668
+ ++ +V ++R+ HD KG W+L V+VR+ S F WL + + +G L
Sbjct: 3172 TPHSLGSVWKIRVWHDNKGLSPAWFLQHVIVRDLQTARS--AFFLVNDWLSVETEANGGL 3229
Query: 669 VRELLPSDSSATLKNFRYHISLKTGDVSGASTDSRVYIKLY 709
V + + + S A L FR L ++ D +++ ++
Sbjct: 3230 VEKEVLAASDAALLRFR---RLLVAELQRGFFDKHIWLSIW 3267
Score = 55.1 bits (131), Expect = 8e-07
Identities = 41/131 (31%), Positives = 68/131 (51%), Gaps = 8/131 (6%)
Query: 298 YIVTVFTGDVRGAGTKSKIYLVMYGARGNKNSGKIFLEGG-VFDRGRTDIFHIELAVLLS 356
Y + V TG RG+GT + + +++YG + SG L+G F R DIF I L
Sbjct: 3120 YEILVKTGWGRGSGTTAHVGIMLYGV--DSRSGHRHLDGDRAFHRNSLDIFRIATPHSLG 3177
Query: 357 PLSRVSVGHGNVGVNRGWFCEKVVILCPFTGIQQTFPCSNWLD-EKKAD-GLIERQLY-- 412
+ ++ V H N G++ WF + V++ T F ++WL E +A+ GL+E+++
Sbjct: 3178 SVWKIRVWHDNKGLSPAWFLQHVIVRDLQTARSAFFLVNDWLSVETEANGGLVEKEVLAA 3237
Query: 413 -EMVSLRKKRL 422
+ LR +RL
Sbjct: 3238 SDAALLRFRRL 3248
Score = 53.5 bits (127), Expect = 2e-06
Identities = 30/92 (32%), Positives = 52/92 (56%), Gaps = 7/92 (7%)
Query: 816 YEVEIWTGDVGGAGTSARVYMQIYGEKGKTEVLFLSSRSKVFERASKDTFQLEAA-DVGE 874
YE+ + TG G+GT+A V + +YG ++ L + F R S D F++ +G
Sbjct: 3120 YEILVKTGWGRGSGTTAHVGIMLYGVDSRSGHRHLDG-DRAFHRNSLDIFRIATPHSLGS 3178
Query: 875 VYKLRLGHTGEGFGPSWFVDTVWLRHLVVREV 906
V+K+R+ H +G P+WF L+H++VR++
Sbjct: 3179 VWKIRVWHDNKGLSPAWF-----LQHVIVRDL 3205
Score = 51.6 bits (122), Expect = 8e-06
Identities = 34/109 (31%), Positives = 53/109 (48%), Gaps = 5/109 (4%)
Query: 1462 YSVQIFTGNIPGAGTDAKVYITIYGDLGDTGERYLGKSENRTNKFERGTADTFIIEAA-D 1520
Y + + TG G+GT A V I +YG +G R+L + F R + D F I
Sbjct: 3120 YEILVKTGWGRGSGTTAHVGIMLYGVDSRSGHRHL----DGDRAFHRNSLDIFRIATPHS 3175
Query: 1521 LGVIYKIKLRHDNSKWCADWYVEKVEIWNDTNEDEFLFLCGRWLSLKKE 1569
LG ++KI++ HDN W+++ V + + FL WLS++ E
Sbjct: 3176 LGSVWKIRVWHDNKGLSPAWFLQHVIVRDLQTARSAFFLVNDWLSVETE 3224
Score = 50.4 bits (119), Expect = 2e-05
Identities = 37/117 (31%), Positives = 62/117 (52%), Gaps = 7/117 (5%)
Query: 684 FRYHISLKTGDVSGASTDSRVYIKLYGDKSDTIKQVLLVSDNNLKDYFERGRVDEFTLET 743
F+Y I +KTG G+ T + V I LYG S + + L D + F R +D F + T
Sbjct: 3118 FKYEILVKTGWGRGSGTTAHVGIMLYGVDSRSGHRHL---DGDRA--FHRNSLDIFRIAT 3172
Query: 744 LN-IGNINRLVIGHDSTGMHASWFLGSVQIRVPRQGKQYTFPANRWLD-KNQADGRL 798
+ +G++ ++ + HD+ G+ +WFL V +R + + F N WL + +A+G L
Sbjct: 3173 PHSLGSVWKIRVWHDNKGLSPAWFLQHVIVRDLQTARSAFFLVNDWLSVETEANGGL 3229
Score = 50.1 bits (118), Expect = 2e-05
Identities = 31/111 (27%), Positives = 52/111 (46%), Gaps = 2/111 (1%)
Query: 424 KFPWSLWVWTTDLKKAGTNSPIFIQIYGQKGRTDEILLNPNNKWFKPGIIEKFRIELP-D 482
+F + + V T + +GT + + I +YG R+ L+ ++ F ++ FRI P
Sbjct: 3117 RFKYEILVKTGWGRGSGTTAHVGIMLYGVDSRSGHRHLD-GDRAFHRNSLDIFRIATPHS 3175
Query: 483 LGRFYKIRVWHDKRSSGSGWHLERMTLMNTLNKDKYNFNCNRWLDANEDDN 533
LG +KIRVWHD + W L+ + + + F N WL + N
Sbjct: 3176 LGSVWKIRVWHDNKGLSPAWFLQHVIVRDLQTARSAFFLVNDWLSVETEAN 3226
Score = 45.4 bits (106), Expect = 6e-04
Identities = 31/115 (26%), Positives = 52/115 (45%), Gaps = 10/115 (8%)
Query: 1308 YEITLYTSDVFAAGTDANIFIIIYGCDAVCTQQKYLCTNKREQKQFFERKSASRFIVELE 1367
YEI + T +GT A++ I++YG D+ + + + F R S F +
Sbjct: 3120 YEILVKTGWGRGSGTTAHVGIMLYGVDSRSGHRHL------DGDRAFHRNSLDIFRIATP 3173
Query: 1368 DVGEIIEKIRIGHNNTGMNPGWHCSHVDIRRLLPDKDGAETLTFPCDRWLATSED 1422
+ KIR+ H+N G++P W HV +R D A + F + WL+ +
Sbjct: 3174 HSLGSVWKIRVWHDNKGLSPAWFLQHVIVR----DLQTARSAFFLVNDWLSVETE 3224
>gi|205360954 polycystin 1 isoform 1 precursor [Homo sapiens]
Length = 4303
Score = 78.2 bits (191), Expect = 8e-14
Identities = 41/104 (39%), Positives = 66/104 (63%), Gaps = 4/104 (3%)
Query: 45 YEVVTATGDVRGAGTDANVFITLFGENGLSPKLQLTSKSKSAFEKGNVDVFRVRT-NNVG 103
YE++ TG RG+GT A+V I L+G + S L AF + ++D+FR+ T +++G
Sbjct: 3120 YEILVKTGWGRGSGTTAHVGIMLYGVDSRSGHRHLDGDR--AFHRNSLDIFRIATPHSLG 3177
Query: 104 LIYKVRIEHDNTGLNASWYLDHVIVTDMKRPHLRYYFNCNNWLS 147
++K+R+ HDN GL+ +W+L HVIV D++ +F N+WLS
Sbjct: 3178 SVWKIRVWHDNKGLSPAWFLQHVIVRDLQTAR-SAFFLVNDWLS 3220
Score = 75.1 bits (183), Expect = 7e-13
Identities = 52/161 (32%), Positives = 79/161 (49%), Gaps = 7/161 (4%)
Query: 1825 YTVAVKTSDILGAGTDANVFIIIFGENGDSGTLALKQSANWNKFERNNTDTFNFPDMLSL 1884
Y + VKT G+GT A+V I+++G + SG L F RN+ D F SL
Sbjct: 3120 YEILVKTGWGRGSGTTAHVGIMLYGVDSRSGHRHLDGD---RAFHRNSLDIFRIATPHSL 3176
Query: 1885 GHLCKLRVWHDNKGIFPGWHLSYVDVKDNSRDETFHFQCDCWLS-KSEGDGQTVRDFACA 1943
G + K+RVWHDNKG+ P W L +V V+D + F + WLS ++E +G V A
Sbjct: 3177 GSVWKIRVWHDNKGLSPAWFLQHVIVRDLQTARSAFFLVNDWLSVETEANGGLVEKEVLA 3236
Query: 1944 NNKICDELEETTYEIVIETGNGGETRENVWLILEGRKNRSK 1984
+ D +++ G +++WL + R RS+
Sbjct: 3237 AS---DAALLRFRRLLVAELQRGFFDKHIWLSIWDRPPRSR 3274
Score = 73.2 bits (178), Expect = 3e-12
Identities = 41/118 (34%), Positives = 68/118 (57%), Gaps = 4/118 (3%)
Query: 173 KYEVKVYTGDVIGAGTDADVFINIFGEYGDTGERRLENEKDNFEKGAEDRFILDAP-DLG 231
KYE+ V TG G+GT A V I ++G +G R L+ ++ F + + D F + P LG
Sbjct: 3119 KYEILVKTGWGRGSGTTAHVGIMLYGVDSRSGHRHLDGDRA-FHRNSLDIFRIATPHSLG 3177
Query: 232 QLMKINVGHNNKGGSAGWFLSQIVIEDIGNKRKYDFPLNRWLALDED--DGKIQRDIL 287
+ KI V H+NKG S WFL +++ D+ R F +N WL+++ + G +++++L
Sbjct: 3178 SVWKIRVWHDNKGLSPAWFLQHVIVRDLQTARSAFFLVNDWLSVETEANGGLVEKEVL 3235
Score = 66.2 bits (160), Expect = 3e-10
Identities = 37/115 (32%), Positives = 61/115 (53%), Gaps = 6/115 (5%)
Query: 1177 FSVTIKTGVKKNAGTDANVFITLFGTQDDTGMTLLKSSKTNSDKFERDSIEIFTVETL-D 1235
+ + +KTG + +GT A+V I L+G +G L + F R+S++IF + T
Sbjct: 3120 YEILVKTGWGRGSGTTAHVGIMLYGVDSRSGHRHLDGDRA----FHRNSLDIFRIATPHS 3175
Query: 1236 LGDLWKVRLGHDNTGKAPGWFVDWVEVDAPSLGKCMTFPCGRWLA-KNEDDGSII 1289
LG +WK+R+ HDN G +P WF+ V V + F WL+ + E +G ++
Sbjct: 3176 LGSVWKIRVWHDNKGLSPAWFLQHVIVRDLQTARSAFFLVNDWLSVETEANGGLV 3230
Score = 62.0 bits (149), Expect = 6e-09
Identities = 35/103 (33%), Positives = 54/103 (52%), Gaps = 3/103 (2%)
Query: 2093 KYEVIVTTGYEPGAGTDANVFVTIFGANGDTGKRELKQKMRNLFERGSTDRFFLET-LEL 2151
KYE++V TG+ G+GT A+V + ++G + +G R L F R S D F + T L
Sbjct: 3119 KYEILVKTGWGRGSGTTAHVGIMLYGVDSRSGHRHLDGD--RAFHRNSLDIFRIATPHSL 3176
Query: 2152 GELRKVRLEHDSSGYCSGWLVEKVEVTNTSTGVATIFNCGRWL 2194
G + K+R+ HD+ G W ++ V V + T + F WL
Sbjct: 3177 GSVWKIRVWHDNKGLSPAWFLQHVIVRDLQTARSAFFLVNDWL 3219
Score = 61.6 bits (148), Expect = 8e-09
Identities = 42/131 (32%), Positives = 66/131 (50%), Gaps = 7/131 (5%)
Query: 1021 RNTYEVQVVTGNVPKAGTDANVYLTIYGEEYGDTGERPLKKSDKSNKFEQGQTDTFTIYA 1080
R YE+ V TG +GT A+V + +YG + +G R L D F + D F I
Sbjct: 3117 RFKYEILVKTGWGRGSGTTAHVGIMLYGVD-SRSGHRHL---DGDRAFHRNSLDIFRIAT 3172
Query: 1081 I-DLGALTKIRIRHDNTGNRAGWFLDRIDITDMNNEITYYFPCQRWLAVEED--DGQLSR 1137
LG++ KIR+ HDN G WFL + + D+ + +F WL+VE + G + +
Sbjct: 3173 PHSLGSVWKIRVWHDNKGLSPAWFLQHVIVRDLQTARSAFFLVNDWLSVETEANGGLVEK 3232
Query: 1138 ELLPVDESYVL 1148
E+L ++ +L
Sbjct: 3233 EVLAASDAALL 3243
Score = 57.4 bits (137), Expect = 2e-07
Identities = 33/102 (32%), Positives = 52/102 (50%), Gaps = 2/102 (1%)
Query: 1698 YEMTVWTGDVVGGGTDSNIFMTLYGINGSTEEMQLDKKKARFEREQNDTF-IMEILDIAP 1756
YE+ V TG G GT +++ + LYG++ + LD +A F R D F I +
Sbjct: 3120 YEILVKTGWGRGSGTTAHVGIMLYGVDSRSGHRHLDGDRA-FHRNSLDIFRIATPHSLGS 3178
Query: 1757 FTKMRIRIDGLGSRPEWFLERILLKNMNTGDLTMFYYGDWLS 1798
K+R+ D G P WFL+ ++++++ T F DWLS
Sbjct: 3179 VWKIRVWHDNKGLSPAWFLQHVIVRDLQTARSAFFLVNDWLS 3220
Score = 55.5 bits (132), Expect = 6e-07
Identities = 45/161 (27%), Positives = 77/161 (47%), Gaps = 11/161 (6%)
Query: 551 GMARYHVTVCTGELEGAGTDANVYLCLFGDVGDTGERLLYNCRNNTDLFEKGNADEFTIE 610
G +Y + V TG G+GT A+V + L+G +G R L R F + + D F I
Sbjct: 3116 GRFKYEILVKTGWGRGSGTTAHVGIMLYGVDSRSGHRHLDGDR----AFHRNSLDIFRIA 3171
Query: 611 SV-TMRNVRRVRIRHDGKGSGSGWYLDRVLVREEGQPESDNVEFPCLRWLDKDKD-DGQL 668
+ ++ +V ++R+ HD KG W+L V+VR+ S F WL + + +G L
Sbjct: 3172 TPHSLGSVWKIRVWHDNKGLSPAWFLQHVIVRDLQTARS--AFFLVNDWLSVETEANGGL 3229
Query: 669 VRELLPSDSSATLKNFRYHISLKTGDVSGASTDSRVYIKLY 709
V + + + S A L FR L ++ D +++ ++
Sbjct: 3230 VEKEVLAASDAALLRFR---RLLVAELQRGFFDKHIWLSIW 3267
Score = 55.1 bits (131), Expect = 8e-07
Identities = 41/131 (31%), Positives = 68/131 (51%), Gaps = 8/131 (6%)
Query: 298 YIVTVFTGDVRGAGTKSKIYLVMYGARGNKNSGKIFLEGG-VFDRGRTDIFHIELAVLLS 356
Y + V TG RG+GT + + +++YG + SG L+G F R DIF I L
Sbjct: 3120 YEILVKTGWGRGSGTTAHVGIMLYGV--DSRSGHRHLDGDRAFHRNSLDIFRIATPHSLG 3177
Query: 357 PLSRVSVGHGNVGVNRGWFCEKVVILCPFTGIQQTFPCSNWLD-EKKAD-GLIERQLY-- 412
+ ++ V H N G++ WF + V++ T F ++WL E +A+ GL+E+++
Sbjct: 3178 SVWKIRVWHDNKGLSPAWFLQHVIVRDLQTARSAFFLVNDWLSVETEANGGLVEKEVLAA 3237
Query: 413 -EMVSLRKKRL 422
+ LR +RL
Sbjct: 3238 SDAALLRFRRL 3248
Score = 53.5 bits (127), Expect = 2e-06
Identities = 30/92 (32%), Positives = 52/92 (56%), Gaps = 7/92 (7%)
Query: 816 YEVEIWTGDVGGAGTSARVYMQIYGEKGKTEVLFLSSRSKVFERASKDTFQLEAA-DVGE 874
YE+ + TG G+GT+A V + +YG ++ L + F R S D F++ +G
Sbjct: 3120 YEILVKTGWGRGSGTTAHVGIMLYGVDSRSGHRHLDG-DRAFHRNSLDIFRIATPHSLGS 3178
Query: 875 VYKLRLGHTGEGFGPSWFVDTVWLRHLVVREV 906
V+K+R+ H +G P+WF L+H++VR++
Sbjct: 3179 VWKIRVWHDNKGLSPAWF-----LQHVIVRDL 3205
Score = 51.6 bits (122), Expect = 8e-06
Identities = 34/109 (31%), Positives = 53/109 (48%), Gaps = 5/109 (4%)
Query: 1462 YSVQIFTGNIPGAGTDAKVYITIYGDLGDTGERYLGKSENRTNKFERGTADTFIIEAA-D 1520
Y + + TG G+GT A V I +YG +G R+L + F R + D F I
Sbjct: 3120 YEILVKTGWGRGSGTTAHVGIMLYGVDSRSGHRHL----DGDRAFHRNSLDIFRIATPHS 3175
Query: 1521 LGVIYKIKLRHDNSKWCADWYVEKVEIWNDTNEDEFLFLCGRWLSLKKE 1569
LG ++KI++ HDN W+++ V + + FL WLS++ E
Sbjct: 3176 LGSVWKIRVWHDNKGLSPAWFLQHVIVRDLQTARSAFFLVNDWLSVETE 3224
Score = 50.4 bits (119), Expect = 2e-05
Identities = 37/117 (31%), Positives = 62/117 (52%), Gaps = 7/117 (5%)
Query: 684 FRYHISLKTGDVSGASTDSRVYIKLYGDKSDTIKQVLLVSDNNLKDYFERGRVDEFTLET 743
F+Y I +KTG G+ T + V I LYG S + + L D + F R +D F + T
Sbjct: 3118 FKYEILVKTGWGRGSGTTAHVGIMLYGVDSRSGHRHL---DGDRA--FHRNSLDIFRIAT 3172
Query: 744 LN-IGNINRLVIGHDSTGMHASWFLGSVQIRVPRQGKQYTFPANRWLD-KNQADGRL 798
+ +G++ ++ + HD+ G+ +WFL V +R + + F N WL + +A+G L
Sbjct: 3173 PHSLGSVWKIRVWHDNKGLSPAWFLQHVIVRDLQTARSAFFLVNDWLSVETEANGGL 3229
Score = 50.1 bits (118), Expect = 2e-05
Identities = 31/111 (27%), Positives = 52/111 (46%), Gaps = 2/111 (1%)
Query: 424 KFPWSLWVWTTDLKKAGTNSPIFIQIYGQKGRTDEILLNPNNKWFKPGIIEKFRIELP-D 482
+F + + V T + +GT + + I +YG R+ L+ ++ F ++ FRI P
Sbjct: 3117 RFKYEILVKTGWGRGSGTTAHVGIMLYGVDSRSGHRHLD-GDRAFHRNSLDIFRIATPHS 3175
Query: 483 LGRFYKIRVWHDKRSSGSGWHLERMTLMNTLNKDKYNFNCNRWLDANEDDN 533
LG +KIRVWHD + W L+ + + + F N WL + N
Sbjct: 3176 LGSVWKIRVWHDNKGLSPAWFLQHVIVRDLQTARSAFFLVNDWLSVETEAN 3226
Score = 45.4 bits (106), Expect = 6e-04
Identities = 31/115 (26%), Positives = 52/115 (45%), Gaps = 10/115 (8%)
Query: 1308 YEITLYTSDVFAAGTDANIFIIIYGCDAVCTQQKYLCTNKREQKQFFERKSASRFIVELE 1367
YEI + T +GT A++ I++YG D+ + + + F R S F +
Sbjct: 3120 YEILVKTGWGRGSGTTAHVGIMLYGVDSRSGHRHL------DGDRAFHRNSLDIFRIATP 3173
Query: 1368 DVGEIIEKIRIGHNNTGMNPGWHCSHVDIRRLLPDKDGAETLTFPCDRWLATSED 1422
+ KIR+ H+N G++P W HV +R D A + F + WL+ +
Sbjct: 3174 HSLGSVWKIRVWHDNKGLSPAWFLQHVIVR----DLQTARSAFFLVNDWLSVETE 3224
>gi|116006951 polycystin 1-like 2 isoform a [Homo sapiens]
Length = 2459
Score = 76.3 bits (186), Expect = 3e-13
Identities = 43/127 (33%), Positives = 69/127 (54%), Gaps = 3/127 (2%)
Query: 1452 EVEEPLDIVLYSVQIFTGNIPGAGTDAKVYITIYGDLGDTGERYLGKSENRTNKFERGTA 1511
E +P Y V ++TG+ GA T +KV +T+YG G+ +L + T FERG
Sbjct: 1382 EDNDPFAQYHYLVTVYTGHRRGAATSSKVTVTLYGLDGEREPHHLADPD--TPVFERGAV 1439
Query: 1512 DTFIIEAA-DLGVIYKIKLRHDNSKWCADWYVEKVEIWNDTNEDEFLFLCGRWLSLKKED 1570
D F++ LG + ++L HDNS WYV +V +++ + ++ FLC WLS+ D
Sbjct: 1440 DAFLLSTLFPLGELRSLRLWHDNSGDRPSWYVSRVLVYDLVMDRKWYFLCNSWLSINVGD 1499
Query: 1571 GRLERLF 1577
L+++F
Sbjct: 1500 CVLDKVF 1506
Score = 74.7 bits (182), Expect = 9e-13
Identities = 44/108 (40%), Positives = 56/108 (51%), Gaps = 1/108 (0%)
Query: 2094 YEVIVTTGYEPGAGTDANVFVTIFGANGDTGKRELKQKMRNLFERGSTDRFFLETL-ELG 2152
Y V V TG+ GA T + V VT++G +G+ L +FERG+ D F L TL LG
Sbjct: 1392 YLVTVYTGHRRGAATSSKVTVTLYGLDGEREPHHLADPDTPVFERGAVDAFLLSTLFPLG 1451
Query: 2153 ELRKVRLEHDSSGYCSGWLVEKVEVTNTSTGVATIFNCGRWLDKKRGD 2200
ELR +RL HD+SG W V +V V + F C WL GD
Sbjct: 1452 ELRSLRLWHDNSGDRPSWYVSRVLVYDLVMDRKWYFLCNSWLSINVGD 1499
Score = 73.6 bits (179), Expect = 2e-12
Identities = 42/109 (38%), Positives = 59/109 (54%), Gaps = 2/109 (1%)
Query: 45 YEVVTATGDVRGAGTDANVFITLFGENGLSPKLQLTSKSKSAFEKGNVDVFRVRT-NNVG 103
Y V TG RGA T + V +TL+G +G L FE+G VD F + T +G
Sbjct: 1392 YLVTVYTGHRRGAATSSKVTVTLYGLDGEREPHHLADPDTPVFERGAVDAFLLSTLFPLG 1451
Query: 104 LIYKVRIEHDNTGLNASWYLDHVIVTDMKRPHLRYYFNCNNWLSKVEGD 152
+ +R+ HDN+G SWY+ V+V D+ ++YF CN+WLS GD
Sbjct: 1452 ELRSLRLWHDNSGDRPSWYVSRVLVYDLVMDR-KWYFLCNSWLSINVGD 1499
Score = 72.4 bits (176), Expect = 5e-12
Identities = 43/136 (31%), Positives = 65/136 (47%), Gaps = 1/136 (0%)
Query: 1798 SQRKGKKTLVCEMCAVIDEEEMMEWTSYTVAVKTSDILGAGTDANVFIIIFGENGDSGTL 1857
++RK + V+++ + Y V V T GA T + V + ++G +G+
Sbjct: 1365 ARRKDAQDQAKVKVTVLEDNDPFAQYHYLVTVYTGHRRGAATSSKVTVTLYGLDGEREPH 1424
Query: 1858 ALKQSANWNKFERNNTDTFNFPDMLSLGHLCKLRVWHDNKGIFPGWHLSYVDVKDNSRDE 1917
L + FER D F + LG L LR+WHDN G P W++S V V D D
Sbjct: 1425 HLADP-DTPVFERGAVDAFLLSTLFPLGELRSLRLWHDNSGDRPSWYVSRVLVYDLVMDR 1483
Query: 1918 TFHFQCDCWLSKSEGD 1933
++F C+ WLS + GD
Sbjct: 1484 KWYFLCNSWLSINVGD 1499
Score = 66.6 bits (161), Expect = 3e-10
Identities = 40/117 (34%), Positives = 63/117 (53%), Gaps = 7/117 (5%)
Query: 1024 YEVQVVTGNVPKAGTDANVYLTIYGEEYGDTGER-PLKKSDKSNK-FEQGQTDTFTIYAI 1081
Y V V TG+ A T + V +T+YG + GER P +D FE+G D F + +
Sbjct: 1392 YLVTVYTGHRRGAATSSKVTVTLYGLD----GEREPHHLADPDTPVFERGAVDAFLLSTL 1447
Query: 1082 -DLGALTKIRIRHDNTGNRAGWFLDRIDITDMNNEITYYFPCQRWLAVEEDDGQLSR 1137
LG L +R+ HDN+G+R W++ R+ + D+ + +YF C WL++ D L +
Sbjct: 1448 FPLGELRSLRLWHDNSGDRPSWYVSRVLVYDLVMDRKWYFLCNSWLSINVGDCVLDK 1504
Score = 66.6 bits (161), Expect = 3e-10
Identities = 36/108 (33%), Positives = 60/108 (55%), Gaps = 2/108 (1%)
Query: 174 YEVKVYTGDVIGAGTDADVFINIFGEYGDTGERRLEN-EKDNFEKGAEDRFILDAP-DLG 231
Y V VYTG GA T + V + ++G G+ L + + FE+GA D F+L LG
Sbjct: 1392 YLVTVYTGHRRGAATSSKVTVTLYGLDGEREPHHLADPDTPVFERGAVDAFLLSTLFPLG 1451
Query: 232 QLMKINVGHNNKGGSAGWFLSQIVIEDIGNKRKYDFPLNRWLALDEDD 279
+L + + H+N G W++S++++ D+ RK+ F N WL+++ D
Sbjct: 1452 ELRSLRLWHDNSGDRPSWYVSRVLVYDLVMDRKWYFLCNSWLSINVGD 1499
Score = 63.5 bits (153), Expect = 2e-09
Identities = 36/134 (26%), Positives = 63/134 (47%), Gaps = 1/134 (0%)
Query: 277 EDDGKIQRDILVGGAETTAITYIVTVFTGDVRGAGTKSKIYLVMYGARGNKNSGKIF-LE 335
+D K++ +L Y+VTV+TG RGA T SK+ + +YG G + + +
Sbjct: 1371 QDQAKVKVTVLEDNDPFAQYHYLVTVYTGHRRGAATSSKVTVTLYGLDGEREPHHLADPD 1430
Query: 336 GGVFDRGRTDIFHIELAVLLSPLSRVSVGHGNVGVNRGWFCEKVVILCPFTGIQQTFPCS 395
VF+RG D F + L L + + H N G W+ +V++ + F C+
Sbjct: 1431 TPVFERGAVDAFLLSTLFPLGELRSLRLWHDNSGDRPSWYVSRVLVYDLVMDRKWYFLCN 1490
Query: 396 NWLDEKKADGLIER 409
+WL D ++++
Sbjct: 1491 SWLSINVGDCVLDK 1504
Score = 62.8 bits (151), Expect = 4e-09
Identities = 38/110 (34%), Positives = 57/110 (51%), Gaps = 3/110 (2%)
Query: 1177 FSVTIKTGVKKNAGTDANVFITLFGTQDDTGMTLLKSSKTNSDKFERDSIEIFTVETL-D 1235
+ VT+ TG ++ A T + V +TL+G + L T FER +++ F + TL
Sbjct: 1392 YLVTVYTGHRRGAATSSKVTVTLYGLDGEREPHHLADPDT--PVFERGAVDAFLLSTLFP 1449
Query: 1236 LGDLWKVRLGHDNTGKAPGWFVDWVEVDAPSLGKCMTFPCGRWLAKNEDD 1285
LG+L +RL HDN+G P W+V V V + + F C WL+ N D
Sbjct: 1450 LGELRSLRLWHDNSGDRPSWYVSRVLVYDLVMDRKWYFLCNSWLSINVGD 1499
Score = 62.0 bits (149), Expect = 6e-09
Identities = 42/136 (30%), Positives = 65/136 (47%), Gaps = 5/136 (3%)
Query: 661 KDKDDGQLVRELLPSDSSATLKNFRYHISLKTGDVSGASTDSRVYIKLYGDKSDTIKQVL 720
KD D V+ + D+ + Y +++ TG GA+T S+V + LYG + L
Sbjct: 1368 KDAQDQAKVKVTVLEDNDP-FAQYHYLVTVYTGHRRGAATSSKVTVTLYGLDGEREPHHL 1426
Query: 721 LVSDNNLKDYFERGRVDEFTLETL-NIGNINRLVIGHDSTGMHASWFLGSVQIRVPRQGK 779
D + FERG VD F L TL +G + L + HD++G SW++ V + +
Sbjct: 1427 ADPDTPV---FERGAVDAFLLSTLFPLGELRSLRLWHDNSGDRPSWYVSRVLVYDLVMDR 1483
Query: 780 QYTFPANRWLDKNQAD 795
++ F N WL N D
Sbjct: 1484 KWYFLCNSWLSINVGD 1499
Score = 61.2 bits (147), Expect = 1e-08
Identities = 40/118 (33%), Positives = 61/118 (51%), Gaps = 2/118 (1%)
Query: 788 WLDKNQADGRLEVELYPSEVVEIQKLVHYEVEIWTGDVGGAGTSARVYMQIYGEKGKTEV 847
W + A + +V++ E + HY V ++TG GA TS++V + +YG G+ E
Sbjct: 1364 WARRKDAQDQAKVKVTVLEDNDPFAQYHYLVTVYTGHRRGAATSSKVTVTLYGLDGEREP 1423
Query: 848 LFLSS-RSKVFERASKDTFQLEAA-DVGEVYKLRLGHTGEGFGPSWFVDTVWLRHLVV 903
L+ + VFER + D F L +GE+ LRL H G PSW+V V + LV+
Sbjct: 1424 HHLADPDTPVFERGAVDAFLLSTLFPLGELRSLRLWHDNSGDRPSWYVSRVLVYDLVM 1481
Score = 59.3 bits (142), Expect = 4e-08
Identities = 41/137 (29%), Positives = 64/137 (46%), Gaps = 4/137 (2%)
Query: 1698 YEMTVWTGDVVGGGTDSNIFMTLYGINGSTEEMQL-DKKKARFEREQNDTFIMEIL-DIA 1755
Y +TV+TG G T S + +TLYG++G E L D FER D F++ L +
Sbjct: 1392 YLVTVYTGHRRGAATSSKVTVTLYGLDGEREPHHLADPDTPVFERGAVDAFLLSTLFPLG 1451
Query: 1756 PFTKMRIRIDGLGSRPEWFLERILLKNMNTGDLTMFYYGDWLSQRKGKKTLVCEMCAVID 1815
+R+ D G RP W++ R+L+ ++ F WLS G V + +
Sbjct: 1452 ELRSLRLWHDNSGDRPSWYVSRVLVYDLVMDRKWYFLCNSWLSINVG--DCVLDKVFPVA 1509
Query: 1816 EEEMMEWTSYTVAVKTS 1832
E+ + S+ +KTS
Sbjct: 1510 TEQDRKQFSHLFFMKTS 1526
Score = 58.9 bits (141), Expect = 5e-08
Identities = 31/111 (27%), Positives = 56/111 (50%), Gaps = 2/111 (1%)
Query: 424 KFPWSLWVWTTDLKKAGTNSPIFIQIYGQKG-RTDEILLNPNNKWFKPGIIEKFRIE-LP 481
++ + + V+T + A T+S + + +YG G R L +P+ F+ G ++ F + L
Sbjct: 1389 QYHYLVTVYTGHRRGAATSSKVTVTLYGLDGEREPHHLADPDTPVFERGAVDAFLLSTLF 1448
Query: 482 DLGRFYKIRVWHDKRSSGSGWHLERMTLMNTLNKDKYNFNCNRWLDANEDD 532
LG +R+WHD W++ R+ + + + K+ F CN WL N D
Sbjct: 1449 PLGELRSLRLWHDNSGDRPSWYVSRVLVYDLVMDRKWYFLCNSWLSINVGD 1499
Score = 56.2 bits (134), Expect = 3e-07
Identities = 45/160 (28%), Positives = 75/160 (46%), Gaps = 11/160 (6%)
Query: 553 ARYH--VTVCTGELEGAGTDANVYLCLFGDVGDTGERLLYNCRNNTDLFEKGNADEFTIE 610
A+YH VTV TG GA T + V + L+G G+ L + +T +FE+G D F +
Sbjct: 1388 AQYHYLVTVYTGHRRGAATSSKVTVTLYGLDGEREPHHLAD--PDTPVFERGAVDAFLLS 1445
Query: 611 SV-TMRNVRRVRIRHDGKGSGSGWYLDRVLVREEGQPESDNVEFPCLRWLDKDKDDGQLV 669
++ + +R +R+ HD G WY+ RVLV + F C WL + D ++
Sbjct: 1446 TLFPLGELRSLRLWHDNSGDRPSWYVSRVLVYDLVMDR--KWYFLCNSWLSINVGD-CVL 1502
Query: 670 RELLPSDSSATLKNFRYHISLKTGDVSGASTDSRVYIKLY 709
++ P + K F + +KT S D ++ ++
Sbjct: 1503 DKVFPVATEQDRKQFSHLFFMKT---SAGFQDGHIWYSIF 1539
Score = 46.2 bits (108), Expect = 4e-04
Identities = 34/123 (27%), Positives = 58/123 (47%), Gaps = 12/123 (9%)
Query: 1304 PFVPYE--ITLYTSDVFAAGTDANIFIIIYGCDAVCTQQKYLCTNKREQKQFFERKSASR 1361
PF Y +T+YT A T + + + +YG D + +L FER +
Sbjct: 1386 PFAQYHYLVTVYTGHRRGAATSSKVTVTLYGLDGE-REPHHLAD---PDTPVFERGAVDA 1441
Query: 1362 FIVE-LEDVGEIIEKIRIGHNNTGMNPGWHCSHVDIRRLLPDKDGAETLTFPCDRWLATS 1420
F++ L +GE+ +R+ H+N+G P W+ S V + L+ D+ F C+ WL+ +
Sbjct: 1442 FLLSTLFPLGEL-RSLRLWHDNSGDRPSWYVSRVLVYDLVMDR----KWYFLCNSWLSIN 1496
Query: 1421 EDD 1423
D
Sbjct: 1497 VGD 1499
>gi|5174633 receptor for egg jelly-like protein precursor [Homo
sapiens]
Length = 2253
Score = 69.7 bits (169), Expect = 3e-11
Identities = 40/125 (32%), Positives = 70/125 (56%), Gaps = 6/125 (4%)
Query: 1455 EPLDIVLYSVQIFTGNIPGAGTDAKVYITIYGDLGDTGERYLGKSENRTNKFERGTADTF 1514
+P D + Y V IFTG+ G+GT A V++ + G + + L T RG+ +TF
Sbjct: 1225 DPYDNLCYLVTIFTGSRWGSGTRANVFVQLRGTVSTSDVHCLSHPHFTT--LYRGSINTF 1282
Query: 1515 IIEA-ADLGVIYKIKLRHDNSKWCADWYVEKVEIWNDTNEDEFLFLCGRWLSLKKEDGRL 1573
++ +DLG I+ I++ H+N WY+ ++++ N + +LF+C +WLS+ D L
Sbjct: 1283 LLTTKSDLGDIHSIRVWHNNEGRSPSWYLSRIKVENLFSRHIWLFICQKWLSV---DTTL 1339
Query: 1574 ERLFY 1578
+R F+
Sbjct: 1340 DRTFH 1344
Score = 67.0 bits (162), Expect = 2e-10
Identities = 42/123 (34%), Positives = 64/123 (52%), Gaps = 12/123 (9%)
Query: 1159 DNNPLDNLALEQKDKSTTFSVTIKTGVKKNAGTDANVFITLFGTQDDTGMTLLKSSKTNS 1218
DN+P DNL + VTI TG + +GT ANVF+ L GT + + L S +
Sbjct: 1223 DNDPYDNLC---------YLVTIFTGSRWGSGTRANVFVQLRGTVSTSDVHCL--SHPHF 1271
Query: 1219 DKFERDSIEIFTVETL-DLGDLWKVRLGHDNTGKAPGWFVDWVEVDAPSLGKCMTFPCGR 1277
R SI F + T DLGD+ +R+ H+N G++P W++ ++V+ F C +
Sbjct: 1272 TTLYRGSINTFLLTTKSDLGDIHSIRVWHNNEGRSPSWYLSRIKVENLFSRHIWLFICQK 1331
Query: 1278 WLA 1280
WL+
Sbjct: 1332 WLS 1334
Score = 62.8 bits (151), Expect = 4e-09
Identities = 41/134 (30%), Positives = 68/134 (50%), Gaps = 2/134 (1%)
Query: 15 FLALYEAELLNYASEDDEGELEHEYYKARVYEVVTATGDVRGAGTDANVFITLFGENGLS 74
F ALY E+ + +++ Y Y V TG G+GT ANVF+ L G S
Sbjct: 1202 FWALYRDEMDQHLRGHVIVLPDNDPYDNLCYLVTIFTGSRWGSGTRANVFVQLRGTVSTS 1261
Query: 75 PKLQLTSKSKSAFEKGNVDVFRVRT-NNVGLIYKVRIEHDNTGLNASWYLDHVIVTDMKR 133
L+ + +G+++ F + T +++G I+ +R+ H+N G + SWYL + V ++
Sbjct: 1262 DVHCLSHPHFTTLYRGSINTFLLTTKSDLGDIHSIRVWHNNEGRSPSWYLSRIKVENLFS 1321
Query: 134 PHLRYYFNCNNWLS 147
H+ + F C WLS
Sbjct: 1322 RHI-WLFICQKWLS 1334
Score = 62.0 bits (149), Expect = 6e-09
Identities = 34/105 (32%), Positives = 59/105 (56%), Gaps = 2/105 (1%)
Query: 174 YEVKVYTGDVIGAGTDADVFINIFGEYGDTGERRLENEK-DNFEKGAEDRFILDAP-DLG 231
Y V ++TG G+GT A+VF+ + G + L + +G+ + F+L DLG
Sbjct: 1232 YLVTIFTGSRWGSGTRANVFVQLRGTVSTSDVHCLSHPHFTTLYRGSINTFLLTTKSDLG 1291
Query: 232 QLMKINVGHNNKGGSAGWFLSQIVIEDIGNKRKYDFPLNRWLALD 276
+ I V HNN+G S W+LS+I +E++ ++ + F +WL++D
Sbjct: 1292 DIHSIRVWHNNEGRSPSWYLSRIKVENLFSRHIWLFICQKWLSVD 1336
Score = 60.5 bits (145), Expect = 2e-08
Identities = 35/116 (30%), Positives = 56/116 (48%), Gaps = 1/116 (0%)
Query: 1813 VIDEEEMMEWTSYTVAVKTSDILGAGTDANVFIIIFGENGDSGTLALKQSANWNKFERNN 1872
V+ + + + Y V + T G+GT ANVF+ + G S L ++ R +
Sbjct: 1220 VLPDNDPYDNLCYLVTIFTGSRWGSGTRANVFVQLRGTVSTSDVHCLSHP-HFTTLYRGS 1278
Query: 1873 TDTFNFPDMLSLGHLCKLRVWHDNKGIFPGWHLSYVDVKDNSRDETFHFQCDCWLS 1928
+TF LG + +RVWH+N+G P W+LS + V++ + F C WLS
Sbjct: 1279 INTFLLTTKSDLGDIHSIRVWHNNEGRSPSWYLSRIKVENLFSRHIWLFICQKWLS 1334
Score = 56.6 bits (135), Expect = 3e-07
Identities = 32/102 (31%), Positives = 51/102 (50%), Gaps = 1/102 (0%)
Query: 2094 YEVIVTTGYEPGAGTDANVFVTIFGANGDTGKRELKQKMRNLFERGSTDRFFLETL-ELG 2152
Y V + TG G+GT ANVFV + G + L RGS + F L T +LG
Sbjct: 1232 YLVTIFTGSRWGSGTRANVFVQLRGTVSTSDVHCLSHPHFTTLYRGSINTFLLTTKSDLG 1291
Query: 2153 ELRKVRLEHDSSGYCSGWLVEKVEVTNTSTGVATIFNCGRWL 2194
++ +R+ H++ G W + +++V N + +F C +WL
Sbjct: 1292 DIHSIRVWHNNEGRSPSWYLSRIKVENLFSRHIWLFICQKWL 1333
Score = 55.5 bits (132), Expect = 6e-07
Identities = 31/93 (33%), Positives = 52/93 (55%), Gaps = 2/93 (2%)
Query: 816 YEVEIWTGDVGGAGTSARVYMQIYGEKGKTEVLFLSS-RSKVFERASKDTFQLEA-ADVG 873
Y V I+TG G+GT A V++Q+ G ++V LS R S +TF L +D+G
Sbjct: 1232 YLVTIFTGSRWGSGTRANVFVQLRGTVSTSDVHCLSHPHFTTLYRGSINTFLLTTKSDLG 1291
Query: 874 EVYKLRLGHTGEGFGPSWFVDTVWLRHLVVREV 906
+++ +R+ H EG PSW++ + + +L R +
Sbjct: 1292 DIHSIRVWHNNEGRSPSWYLSRIKVENLFSRHI 1324
Score = 55.1 bits (131), Expect = 8e-07
Identities = 32/107 (29%), Positives = 54/107 (50%), Gaps = 3/107 (2%)
Query: 1024 YEVQVVTGNVPKAGTDANVYLTIYGEEYGDTGERPLKKSDKSNKFEQGQTDTFTIYA-ID 1082
Y V + TG+ +GT ANV++ + G T + +G +TF + D
Sbjct: 1232 YLVTIFTGSRWGSGTRANVFVQLRGTV--STSDVHCLSHPHFTTLYRGSINTFLLTTKSD 1289
Query: 1083 LGALTKIRIRHDNTGNRAGWFLDRIDITDMNNEITYYFPCQRWLAVE 1129
LG + IR+ H+N G W+L RI + ++ + + F CQ+WL+V+
Sbjct: 1290 LGDIHSIRVWHNNEGRSPSWYLSRIKVENLFSRHIWLFICQKWLSVD 1336
Score = 53.5 bits (127), Expect = 2e-06
Identities = 36/137 (26%), Positives = 60/137 (43%), Gaps = 18/137 (13%)
Query: 1308 YEITLYTSDVFAAGTDANIFIIIYGC----DAVCTQQKYLCTNKREQKQFFERKSASRFI 1363
Y +T++T + +GT AN+F+ + G D C + T R S + F+
Sbjct: 1232 YLVTIFTGSRWGSGTRANVFVQLRGTVSTSDVHCLSHPHFTT--------LYRGSINTFL 1283
Query: 1364 VELE-DVGEIIEKIRIGHNNTGMNPGWHCSHVDIRRLLPDKDGAETLTFPCDRWLATSED 1422
+ + D+G+I IR+ HNN G +P W+ S + + L F C +WL+
Sbjct: 1284 LTTKSDLGDI-HSIRVWHNNEGRSPSWYLSRIKVENLF----SRHIWLFICQKWLSVDTT 1338
Query: 1423 DKKTIRELVPYDIFTEK 1439
+T P + T K
Sbjct: 1339 LDRTFHVTHPDERLTRK 1355
Score = 52.4 bits (124), Expect = 5e-06
Identities = 27/93 (29%), Positives = 46/93 (49%), Gaps = 2/93 (2%)
Query: 439 AGTNSPIFIQIYGQKGRTD-EILLNPNNKWFKPGIIEKFRIELP-DLGRFYKIRVWHDKR 496
+GT + +F+Q+ G +D L +P+ G I F + DLG + IRVWH+
Sbjct: 1244 SGTRANVFVQLRGTVSTSDVHCLSHPHFTTLYRGSINTFLLTTKSDLGDIHSIRVWHNNE 1303
Query: 497 SSGSGWHLERMTLMNTLNKDKYNFNCNRWLDAN 529
W+L R+ + N ++ + F C +WL +
Sbjct: 1304 GRSPSWYLSRIKVENLFSRHIWLFICQKWLSVD 1336
Score = 46.6 bits (109), Expect = 3e-04
Identities = 32/109 (29%), Positives = 53/109 (48%), Gaps = 5/109 (4%)
Query: 555 YHVTVCTGELEGAGTDANVYLCLFGDVGDTGERLLYNCRNNTDLFEKGNADEFTIESVT- 613
Y VT+ TG G+GT ANV++ L G V + L + T +G+ + F + + +
Sbjct: 1232 YLVTIFTGSRWGSGTRANVFVQLRGTVSTSDVHCLSHPHFTT--LYRGSINTFLLTTKSD 1289
Query: 614 MRNVRRVRIRHDGKGSGSGWYLDRVLVREEGQPESDNVEFPCLRWLDKD 662
+ ++ +R+ H+ +G WYL R+ V E F C +WL D
Sbjct: 1290 LGDIHSIRVWHNNEGRSPSWYLSRIKV--ENLFSRHIWLFICQKWLSVD 1336
Score = 45.1 bits (105), Expect = 8e-04
Identities = 28/103 (27%), Positives = 51/103 (49%), Gaps = 2/103 (1%)
Query: 1698 YEMTVWTGDVVGGGTDSNIFMTLYGINGSTEEMQLDKKK-ARFEREQNDTFIMEIL-DIA 1755
Y +T++TG G GT +N+F+ L G +++ L R +TF++ D+
Sbjct: 1232 YLVTIFTGSRWGSGTRANVFVQLRGTVSTSDVHCLSHPHFTTLYRGSINTFLLTTKSDLG 1291
Query: 1756 PFTKMRIRIDGLGSRPEWFLERILLKNMNTGDLTMFYYGDWLS 1798
+R+ + G P W+L RI ++N+ + + +F WLS
Sbjct: 1292 DIHSIRVWHNNEGRSPSWYLSRIKVENLFSRHIWLFICQKWLS 1334
Score = 43.9 bits (102), Expect = 0.002
Identities = 34/149 (22%), Positives = 69/149 (46%), Gaps = 4/149 (2%)
Query: 659 LDKDKDDGQLVRELLPSDSSATLKNFRYHISLKTGDVSGASTDSRVYIKLYGDKSDTIKQ 718
L +D+ D L ++ + N Y +++ TG G+ T + V+++L G S +
Sbjct: 1205 LYRDEMDQHLRGHVIVLPDNDPYDNLCYLVTIFTGSRWGSGTRANVFVQLRGTVSTS--D 1262
Query: 719 VLLVSDNNLKDYFERGRVDEFTLETLN-IGNINRLVIGHDSTGMHASWFLGSVQIRVPRQ 777
V +S + + RG ++ F L T + +G+I+ + + H++ G SW+L +++
Sbjct: 1263 VHCLSHPHFTTLY-RGSINTFLLTTKSDLGDIHSIRVWHNNEGRSPSWYLSRIKVENLFS 1321
Query: 778 GKQYTFPANRWLDKNQADGRLEVELYPSE 806
+ F +WL + R +P E
Sbjct: 1322 RHIWLFICQKWLSVDTTLDRTFHVTHPDE 1350
Score = 40.8 bits (94), Expect = 0.015
Identities = 25/107 (23%), Positives = 48/107 (44%), Gaps = 7/107 (6%)
Query: 296 ITYIVTVFTGDVRGAGTKSKIYLVMYGARGNKNSGKIFL----EGGVFDRGRTDIFHIEL 351
+ Y+VT+FTG G+GT++ +++ + RG ++ + RG + F +
Sbjct: 1230 LCYLVTIFTGSRWGSGTRANVFVQL---RGTVSTSDVHCLSHPHFTTLYRGSINTFLLTT 1286
Query: 352 AVLLSPLSRVSVGHGNVGVNRGWFCEKVVILCPFTGIQQTFPCSNWL 398
L + + V H N G + W+ ++ + F+ F C WL
Sbjct: 1287 KSDLGDIHSIRVWHNNEGRSPSWYLSRIKVENLFSRHIWLFICQKWL 1333
>gi|122891862 DENN/MADD domain containing 5B [Homo sapiens]
Length = 1274
Score = 65.9 bits (159), Expect = 4e-10
Identities = 46/122 (37%), Positives = 60/122 (49%), Gaps = 12/122 (9%)
Query: 1178 SVTIKTGVKKNAGTDANVFITLFGTQDDTGMTLLKSSKTNSDKFERDSIEIFTVETLDLG 1237
SV I NA +N +I + G DTG+ + ++ +E+ T E +LG
Sbjct: 940 SVIIPIKKLSNAIITSNPWICVSGELGDTGVM----------QIPKNLLEM-TFECQNLG 988
Query: 1238 DLWKVRLGHDNTGKAPGWFVDWVEVDAPSLGKCMTFPCGRWLAKNEDDGSIIRDLFHAEL 1297
L V++GHDN+G W VD V V G FPCGRWL K DDGS+ R L EL
Sbjct: 989 KLTTVQIGHDNSGLLAKWLVDCVMVRNEITGHTYRFPCGRWLGKGIDDGSLERILI-GEL 1047
Query: 1298 QT 1299
T
Sbjct: 1048 MT 1049
Score = 61.2 bits (147), Expect = 1e-08
Identities = 49/177 (27%), Positives = 81/177 (45%), Gaps = 18/177 (10%)
Query: 2030 IPKRELAWHVKTIT----ITEMEYGNVYFFNCDCLIPLKRKRKYFKVFEVTKTTESFASK 2085
+ K+ L+ H+K + +T+ Y F C+ +R++ + + + +
Sbjct: 874 LEKKLLSQHLKQLLSNQPLTKKLYKRYAFLRCE----EEREQFLYHLLSLNAVDYFCFTS 929
Query: 2086 VQSLVPVKYE-VIVTTGYEPGAGTDANVFVTIFGANGDTGKRELKQKMRNLFERGSTDRF 2144
V + + + Y VI+ A +N ++ + G GDTG ++ +NL E
Sbjct: 930 VFTTIMIPYRSVIIPIKKLSNAIITSNPWICVSGELGDTGVMQIP---KNLLE------M 980
Query: 2145 FLETLELGELRKVRLEHDSSGYCSGWLVEKVEVTNTSTGVATIFNCGRWLDKKRGDG 2201
E LG+L V++ HD+SG + WLV+ V V N TG F CGRWL K DG
Sbjct: 981 TFECQNLGKLTTVQIGHDNSGLLAKWLVDCVMVRNEITGHTYRFPCGRWLGKGIDDG 1037
Score = 60.5 bits (145), Expect = 2e-08
Identities = 47/152 (30%), Positives = 72/152 (47%), Gaps = 22/152 (14%)
Query: 1481 YITIYGDLGDTGERYLGKSENRTNKFERGTADTFIIEAADLGVIYKIKLRHDNSKWCADW 1540
+I + G+LGDTG + K N E TF E +LG + +++ HDNS A W
Sbjct: 958 WICVSGELGDTGVMQIPK-----NLLEM----TF--ECQNLGKLTTVQIGHDNSGLLAKW 1006
Query: 1541 YVEKVEIWNDTNEDEFLFLCGRWLSLKKEDGRLERLFYEKEYTG----DRSSNCSSPADF 1596
V+ V + N+ + F CGRWL +DG LER+ + T D C +P
Sbjct: 1007 LVDCVMVRNEITGHTYRFPCGRWLGKGIDDGSLERILIGELMTSASDEDLVKQCRTPPQQ 1066
Query: 1597 WEIALSSKMADVDISTVTG----PMADYVQEG 1624
+ +++ I+++TG P A +QEG
Sbjct: 1067 KSPTTARRLS---ITSLTGKNNKPNAGQIQEG 1095
Score = 58.5 bits (140), Expect = 7e-08
Identities = 36/101 (35%), Positives = 51/101 (50%), Gaps = 11/101 (10%)
Query: 1040 ANVYLTIYGEEYGDTGERPLKKSDKSNKFEQGQTDTFTIYAIDLGALTKIRIRHDNTGNR 1099
+N ++ + GE GDTG + K+ FE +LG LT ++I HDN+G
Sbjct: 955 SNPWICVSGE-LGDTGVMQIPKNLLEMTFE----------CQNLGKLTTVQIGHDNSGLL 1003
Query: 1100 AGWFLDRIDITDMNNEITYYFPCQRWLAVEEDDGQLSRELL 1140
A W +D + + + TY FPC RWL DDG L R L+
Sbjct: 1004 AKWLVDCVMVRNEITGHTYRFPCGRWLGKGIDDGSLERILI 1044
Score = 58.2 bits (139), Expect = 9e-08
Identities = 36/105 (34%), Positives = 50/105 (47%), Gaps = 12/105 (11%)
Query: 695 VSGASTDSRVYIKLYGDKSDTIKQVLLVSDNNLKDYFERGRVDEFTLETLNIGNINRLVI 754
+S A S +I + G+ DT V+ + N L E T E N+G + + I
Sbjct: 948 LSNAIITSNPWICVSGELGDT--GVMQIPKNLL----------EMTFECQNLGKLTTVQI 995
Query: 755 GHDSTGMHASWFLGSVQIRVPRQGKQYTFPANRWLDKNQADGRLE 799
GHD++G+ A W + V +R G Y FP RWL K DG LE
Sbjct: 996 GHDNSGLLAKWLVDCVMVRNEITGHTYRFPCGRWLGKGIDDGSLE 1040
Score = 57.4 bits (137), Expect = 2e-07
Identities = 37/111 (33%), Positives = 52/111 (46%), Gaps = 13/111 (11%)
Query: 563 ELEGAGTDANVYLCLFGDVGDTGERLLYNCRNNTDLFEKGNADEFTIESVTMRNVRRVRI 622
+L A +N ++C+ G++GDTG + N E T E + + V+I
Sbjct: 947 KLSNAIITSNPWICVSGELGDTGVMQIPK-----------NLLEMTFECQNLGKLTTVQI 995
Query: 623 RHDGKGSGSGWYLDRVLVREEGQPESDNVEFPCLRWLDKDKDDGQLVRELL 673
HD G + W +D V+VR E FPC RWL K DDG L R L+
Sbjct: 996 GHDNSGLLAKWLVDCVMVRNE--ITGHTYRFPCGRWLGKGIDDGSLERILI 1044
Score = 55.1 bits (131), Expect = 8e-07
Identities = 33/103 (32%), Positives = 53/103 (51%), Gaps = 9/103 (8%)
Query: 193 FINIFGEYGDTGERRLENEKDNFEKGAEDRFILDAPDLGQLMKINVGHNNKGGSAGWFLS 252
+I + GE GDTG ++ K+ E + +LG+L + +GH+N G A W +
Sbjct: 958 WICVSGELGDTGVMQIP--KNLLE------MTFECQNLGKLTTVQIGHDNSGLLAKWLVD 1009
Query: 253 QIVIEDIGNKRKYDFPLNRWLALDEDDGKIQRDILVGGAETTA 295
+++ + Y FP RWL DDG ++R IL+G T+A
Sbjct: 1010 CVMVRNEITGHTYRFPCGRWLGKGIDDGSLER-ILIGELMTSA 1051
Score = 52.0 bits (123), Expect = 6e-06
Identities = 31/113 (27%), Positives = 50/113 (44%), Gaps = 11/113 (9%)
Query: 1826 TVAVKTSDILGAGTDANVFIIIFGENGDSGTLALKQSANWNKFERNNTDTFNFPDMLSLG 1885
+V + + A +N +I + GE GD+G + + ++ FE N LG
Sbjct: 940 SVIIPIKKLSNAIITSNPWICVSGELGDTGVMQIPKNLLEMTFECQN-----------LG 988
Query: 1886 HLCKLRVWHDNKGIFPGWHLSYVDVKDNSRDETFHFQCDCWLSKSEGDGQTVR 1938
L +++ HDN G+ W + V V++ T+ F C WL K DG R
Sbjct: 989 KLTTVQIGHDNSGLLAKWLVDCVMVRNEITGHTYRFPCGRWLGKGIDDGSLER 1041
Score = 43.5 bits (101), Expect = 0.002
Identities = 21/57 (36%), Positives = 29/57 (50%)
Query: 355 LSPLSRVSVGHGNVGVNRGWFCEKVVILCPFTGIQQTFPCSNWLDEKKADGLIERQL 411
L L+ V +GH N G+ W + V++ TG FPC WL + DG +ER L
Sbjct: 987 LGKLTTVQIGHDNSGLLAKWLVDCVMVRNEITGHTYRFPCGRWLGKGIDDGSLERIL 1043
Score = 42.4 bits (98), Expect = 0.005
Identities = 28/88 (31%), Positives = 42/88 (47%), Gaps = 10/88 (11%)
Query: 61 ANVFITLFGENGLSPKLQLTSKSKSAFEKGNVDVFRVRTNNVGLIYKVRIEHDNTGLNAS 120
+N +I + GE G + +Q+ N+ N+G + V+I HDN+GL A
Sbjct: 955 SNPWICVSGELGDTGVMQIPK---------NLLEMTFECQNLGKLTTVQIGHDNSGLLAK 1005
Query: 121 WYLDHVIVTDMKRPHLRYYFNCNNWLSK 148
W +D V+V + H Y F C WL K
Sbjct: 1006 WLVDCVMVRNEITGH-TYRFPCGRWLGK 1032
Score = 39.7 bits (91), Expect = 0.033
Identities = 18/73 (24%), Positives = 33/73 (45%)
Query: 470 PGIIEKFRIELPDLGRFYKIRVWHDKRSSGSGWHLERMTLMNTLNKDKYNFNCNRWLDAN 529
P + + E +LG+ +++ HD + W ++ + + N + Y F C RWL
Sbjct: 974 PKNLLEMTFECQNLGKLTTVQIGHDNSGLLAKWLVDCVMVRNEITGHTYRFPCGRWLGKG 1033
Query: 530 EDDNEIVREMTAE 542
DD + R + E
Sbjct: 1034 IDDGSLERILIGE 1046
Score = 38.1 bits (87), Expect = 0.097
Identities = 22/75 (29%), Positives = 36/75 (48%), Gaps = 5/75 (6%)
Query: 1357 KSASRFIVELEDVGEIIEKIRIGHNNTGMNPGWHCSHVDIRRLLPDKDGAETLTFPCDRW 1416
K+ E +++G++ ++IGH+N+G+ W V +R + T FPC RW
Sbjct: 975 KNLLEMTFECQNLGKLTT-VQIGHDNSGLLAKWLVDCVMVRNEIT----GHTYRFPCGRW 1029
Query: 1417 LATSEDDKKTIRELV 1431
L DD R L+
Sbjct: 1030 LGKGIDDGSLERILI 1044
Score = 32.3 bits (72), Expect = 5.3
Identities = 28/114 (24%), Positives = 52/114 (45%), Gaps = 16/114 (14%)
Query: 1714 SNIFMTLYGINGSTEEMQLDKKKARFEREQNDTFIMEILDIAPFTKMRIRIDGLGSRPEW 1773
SN ++ + G G T MQ+ K TF E ++ T ++I D G +W
Sbjct: 955 SNPWICVSGELGDTGVMQIPKNLLEM------TF--ECQNLGKLTTVQIGHDNSGLLAKW 1006
Query: 1774 FLERILLKNMNTGDLTMFYYGDWLSQRKG------KKTLVCEMCAVIDEEEMME 1821
++ ++++N TG F G WL KG ++ L+ E+ +E++++
Sbjct: 1007 LVDCVMVRNEITGHTYRFPCGRWLG--KGIDDGSLERILIGELMTSASDEDLVK 1058
>gi|44889475 RAB6 interacting protein 1 [Homo sapiens]
Length = 1287
Score = 63.9 bits (154), Expect = 2e-09
Identities = 48/175 (27%), Positives = 81/175 (46%), Gaps = 18/175 (10%)
Query: 2032 KRELAWHVKTIT----ITEMEYGNVYFFNCDCLIPLKRKRKYFKVFEVTKTTESFASKVQ 2087
K+ L+ H+K + +T+ Y F CD ++++ + + + V
Sbjct: 894 KKLLSRHLKQLLSDHELTKKLYKRYAFLRCDD----EKEQFLYHLLSFNAVDYFCFTNVF 949
Query: 2088 SLVPVKYEVIVTTGYEPGAGT-DANVFVTIFGANGDTGKRELKQKMRNLFERGSTDRFFL 2146
+ + + Y +++ + G AN ++ I +G+ G+ ++ Q RN+ E
Sbjct: 950 TTILIPYHILIVPSKKLGGSMFTANPWICI---SGELGETQIMQIPRNVLE------MTF 1000
Query: 2147 ETLELGELRKVRLEHDSSGYCSGWLVEKVEVTNTSTGVATIFNCGRWLDKKRGDG 2201
E LG+L V++ HD+SG + WLVE V V N TG F CGRWL K DG
Sbjct: 1001 ECQNLGKLTTVQIGHDNSGLYAKWLVEYVMVRNEITGHTYKFPCGRWLGKGMDDG 1055
Score = 61.6 bits (148), Expect = 8e-09
Identities = 33/78 (42%), Positives = 45/78 (57%), Gaps = 1/78 (1%)
Query: 1215 KTNSDKFERDSIEIFTVETLDLGDLWKVRLGHDNTGKAPGWFVDWVEVDAPSLGKCMTFP 1274
+T + R+ +E+ T E +LG L V++GHDN+G W V++V V G FP
Sbjct: 985 ETQIMQIPRNVLEM-TFECQNLGKLTTVQIGHDNSGLYAKWLVEYVMVRNEITGHTYKFP 1043
Query: 1275 CGRWLAKNEDDGSIIRDL 1292
CGRWL K DDGS+ R L
Sbjct: 1044 CGRWLGKGMDDGSLERIL 1061
Score = 61.2 bits (147), Expect = 1e-08
Identities = 36/115 (31%), Positives = 57/115 (49%), Gaps = 13/115 (11%)
Query: 686 YHISL-KTGDVSGASTDSRVYIKLYGDKSDTIKQVLLVSDNNLKDYFERGRVDEFTLETL 744
YHI + + + G+ + +I + G+ +T Q++ + N L E T E
Sbjct: 956 YHILIVPSKKLGGSMFTANPWICISGELGET--QIMQIPRNVL----------EMTFECQ 1003
Query: 745 NIGNINRLVIGHDSTGMHASWFLGSVQIRVPRQGKQYTFPANRWLDKNQADGRLE 799
N+G + + IGHD++G++A W + V +R G Y FP RWL K DG LE
Sbjct: 1004 NLGKLTTVQIGHDNSGLYAKWLVEYVMVRNEITGHTYKFPCGRWLGKGMDDGSLE 1058
Score = 57.4 bits (137), Expect = 2e-07
Identities = 38/120 (31%), Positives = 60/120 (50%), Gaps = 14/120 (11%)
Query: 555 YHVTVCTGE-LEGAGTDANVYLCLFGDVGDTGERLLYNCRNNTDLFEKGNADEFTIESVT 613
YH+ + + L G+ AN ++C+ G++G+T +++ RN E T E
Sbjct: 956 YHILIVPSKKLGGSMFTANPWICISGELGET--QIMQIPRNVL---------EMTFECQN 1004
Query: 614 MRNVRRVRIRHDGKGSGSGWYLDRVLVREEGQPESDNVEFPCLRWLDKDKDDGQLVRELL 673
+ + V+I HD G + W ++ V+VR E +FPC RWL K DDG L R L+
Sbjct: 1005 LGKLTTVQIGHDNSGLYAKWLVEYVMVRNE--ITGHTYKFPCGRWLGKGMDDGSLERILV 1062
Score = 53.9 bits (128), Expect = 2e-06
Identities = 32/114 (28%), Positives = 53/114 (46%), Gaps = 11/114 (9%)
Query: 1825 YTVAVKTSDILGAGTDANVFIIIFGENGDSGTLALKQSANWNKFERNNTDTFNFPDMLSL 1884
+ + V + + G+ AN +I I GE G++ + + ++ FE N L
Sbjct: 957 HILIVPSKKLGGSMFTANPWICISGELGETQIMQIPRNVLEMTFECQN-----------L 1005
Query: 1885 GHLCKLRVWHDNKGIFPGWHLSYVDVKDNSRDETFHFQCDCWLSKSEGDGQTVR 1938
G L +++ HDN G++ W + YV V++ T+ F C WL K DG R
Sbjct: 1006 GKLTTVQIGHDNSGLYAKWLVEYVMVRNEITGHTYKFPCGRWLGKGMDDGSLER 1059
Score = 53.5 bits (127), Expect = 2e-06
Identities = 36/104 (34%), Positives = 52/104 (50%), Gaps = 11/104 (10%)
Query: 1473 GAGTDAKVYITIYGDLGDTGERYLGKSENRTNKFERGTADTFIIEAADLGVIYKIKLRHD 1532
G+ A +I I G+LG+T + + N E TF E +LG + +++ HD
Sbjct: 968 GSMFTANPWICISGELGETQIMQIPR-----NVLEM----TF--ECQNLGKLTTVQIGHD 1016
Query: 1533 NSKWCADWYVEKVEIWNDTNEDEFLFLCGRWLSLKKEDGRLERL 1576
NS A W VE V + N+ + F CGRWL +DG LER+
Sbjct: 1017 NSGLYAKWLVEYVMVRNEITGHTYKFPCGRWLGKGMDDGSLERI 1060
Score = 53.1 bits (126), Expect = 3e-06
Identities = 25/59 (42%), Positives = 35/59 (59%)
Query: 1082 DLGALTKIRIRHDNTGNRAGWFLDRIDITDMNNEITYYFPCQRWLAVEEDDGQLSRELL 1140
+LG LT ++I HDN+G A W ++ + + + TY FPC RWL DDG L R L+
Sbjct: 1004 NLGKLTTVQIGHDNSGLYAKWLVEYVMVRNEITGHTYKFPCGRWLGKGMDDGSLERILV 1062
Score = 51.6 bits (122), Expect = 8e-06
Identities = 32/105 (30%), Positives = 54/105 (51%), Gaps = 9/105 (8%)
Query: 185 GAGTDADVFINIFGEYGDTGERRLENEKDNFEKGAEDRFILDAPDLGQLMKINVGHNNKG 244
G+ A+ +I I GE G+T + ++ ++ E + +LG+L + +GH+N G
Sbjct: 968 GSMFTANPWICISGELGET--QIMQIPRNVLE------MTFECQNLGKLTTVQIGHDNSG 1019
Query: 245 GSAGWFLSQIVIEDIGNKRKYDFPLNRWLALDEDDGKIQRDILVG 289
A W + +++ + Y FP RWL DDG ++R ILVG
Sbjct: 1020 LYAKWLVEYVMVRNEITGHTYKFPCGRWLGKGMDDGSLER-ILVG 1063
Score = 47.4 bits (111), Expect = 2e-04
Identities = 28/78 (35%), Positives = 35/78 (44%), Gaps = 8/78 (10%)
Query: 342 GRTDIFHIELAVL--------LSPLSRVSVGHGNVGVNRGWFCEKVVILCPFTGIQQTFP 393
G T I I VL L L+ V +GH N G+ W E V++ TG FP
Sbjct: 984 GETQIMQIPRNVLEMTFECQNLGKLTTVQIGHDNSGLYAKWLVEYVMVRNEITGHTYKFP 1043
Query: 394 CSNWLDEKKADGLIERQL 411
C WL + DG +ER L
Sbjct: 1044 CGRWLGKGMDDGSLERIL 1061
Score = 46.2 bits (108), Expect = 4e-04
Identities = 30/93 (32%), Positives = 45/93 (48%), Gaps = 10/93 (10%)
Query: 56 GAGTDANVFITLFGENGLSPKLQLTSKSKSAFEKGNVDVFRVRTNNVGLIYKVRIEHDNT 115
G+ AN +I + GE G + +Q+ NV N+G + V+I HDN+
Sbjct: 968 GSMFTANPWICISGELGETQIMQIPR---------NVLEMTFECQNLGKLTTVQIGHDNS 1018
Query: 116 GLNASWYLDHVIVTDMKRPHLRYYFNCNNWLSK 148
GL A W +++V+V + H Y F C WL K
Sbjct: 1019 GLYAKWLVEYVMVRNEITGH-TYKFPCGRWLGK 1050
Score = 44.7 bits (104), Expect = 0.001
Identities = 26/97 (26%), Positives = 44/97 (45%), Gaps = 8/97 (8%)
Query: 446 FIQIYGQKGRTDEILLNPNNKWFKPGIIEKFRIELPDLGRFYKIRVWHDKRSSGSGWHLE 505
+I I G+ G T +I+ P N + + E +LG+ +++ HD + W +E
Sbjct: 976 WICISGELGET-QIMQIPRN-------VLEMTFECQNLGKLTTVQIGHDNSGLYAKWLVE 1027
Query: 506 RMTLMNTLNKDKYNFNCNRWLDANEDDNEIVREMTAE 542
+ + N + Y F C RWL DD + R + E
Sbjct: 1028 YVMVRNEITGHTYKFPCGRWLGKGMDDGSLERILVGE 1064
Score = 40.8 bits (94), Expect = 0.015
Identities = 22/67 (32%), Positives = 35/67 (52%), Gaps = 5/67 (7%)
Query: 1365 ELEDVGEIIEKIRIGHNNTGMNPGWHCSHVDIRRLLPDKDGAETLTFPCDRWLATSEDDK 1424
E +++G++ ++IGH+N+G+ W +V +R + T FPC RWL DD
Sbjct: 1001 ECQNLGKLTT-VQIGHDNSGLYAKWLVEYVMVRNEIT----GHTYKFPCGRWLGKGMDDG 1055
Query: 1425 KTIRELV 1431
R LV
Sbjct: 1056 SLERILV 1062
Score = 33.9 bits (76), Expect = 1.8
Identities = 26/111 (23%), Positives = 49/111 (44%), Gaps = 9/111 (8%)
Query: 1690 IIKKIEVLYEMTVWTGDVVGGGT-DSNIFMTLYGINGSTEEMQLDKKKARFEREQNDTFI 1748
+ I + Y + + +GG +N ++ + G G T+ MQ+ + TF
Sbjct: 948 VFTTILIPYHILIVPSKKLGGSMFTANPWICISGELGETQIMQIPRNVLEM------TF- 1000
Query: 1749 MEILDIAPFTKMRIRIDGLGSRPEWFLERILLKNMNTGDLTMFYYGDWLSQ 1799
E ++ T ++I D G +W +E ++++N TG F G WL +
Sbjct: 1001 -ECQNLGKLTTVQIGHDNSGLYAKWLVEYVMVRNEITGHTYKFPCGRWLGK 1050
Score = 33.1 bits (74), Expect = 3.1
Identities = 19/76 (25%), Positives = 41/76 (53%), Gaps = 8/76 (10%)
Query: 825 VGGAGTSARVYMQIYGEKGKTEVLFLSSRSKVFERASKDTFQLEAADVGEVYKLRLGHTG 884
+GG+ +A ++ I GE G+T+++ ++ + TF E ++G++ +++GH
Sbjct: 966 LGGSMFTANPWICISGELGETQIM------QIPRNVLEMTF--ECQNLGKLTTVQIGHDN 1017
Query: 885 EGFGPSWFVDTVWLRH 900
G W V+ V +R+
Sbjct: 1018 SGLYAKWLVEYVMVRN 1033
>gi|221219020 NYD-SP11 protein [Homo sapiens]
Length = 2873
Score = 59.3 bits (142), Expect = 4e-08
Identities = 42/119 (35%), Positives = 68/119 (57%), Gaps = 7/119 (5%)
Query: 905 EVDLTPEEEARKKKEKDKLRQLLKKERLKAKLQRKKKKRKGSDEEDEGEEEESSSSE--- 961
E ++ EEE RK++E+ + +Q+ K+E K K +++KKK + ++E+ EE+E SE
Sbjct: 2259 EEEVREEEEERKEEEEGEEKQVEKEEEEKKKKKKEKKKEEVQEKEEVFEEKEEIMSEEET 2318
Query: 962 ESSSEEEEMEEEEEEEEFGPGMQEVIEQHK----FEAHRWLARGKEDNELVVELVPAGK 1016
ES S+EEE EE EE +E++++ K E R RG+E ++ VP GK
Sbjct: 2319 ESLSDEEEEEESCSLEEEVDREKEILKKEKQFKLQEQRRKSLRGRERVLSILRGVPHGK 2377
Score = 44.7 bits (104), Expect = 0.001
Identities = 29/94 (30%), Positives = 45/94 (47%), Gaps = 18/94 (19%)
Query: 903 VREVDLTPEEEARKKKEKDKLRQLLKKERLKAKLQR------------------KKKKRK 944
+ E ++ P + R +K K+ R KE+ +++ +K++
Sbjct: 2184 IEEEEVIPFLKRRWRKRKEAKRGDKPKEKFSSQVDEVESEEHFSEEMESLLDELEKQESL 2243
Query: 945 GSDEEDEGEEEESSSSEESSSEEEEMEEEEEEEE 978
S+EE+E EEEE EE EEEE +EEEE EE
Sbjct: 2244 SSEEEEEREEEEEREEEEVREEEEERKEEEEGEE 2277
Score = 44.7 bits (104), Expect = 0.001
Identities = 24/74 (32%), Positives = 46/74 (62%), Gaps = 1/74 (1%)
Query: 905 EVDLTPEEEARKKKEKDKLRQLLKKERLKAKLQRKKKKRKGSDEEDEGEEEESSSSEESS 964
+VD EE ++ + L +L K+E L ++ + ++++ + +EE+ EEEE EE
Sbjct: 2216 QVDEVESEEHFSEEMESLLDELEKQESLSSEEEEEREEEEEREEEEVREEEE-ERKEEEE 2274
Query: 965 SEEEEMEEEEEEEE 978
EE+++E+EEEE++
Sbjct: 2275 GEEKQVEKEEEEKK 2288
Score = 42.4 bits (98), Expect = 0.005
Identities = 32/108 (29%), Positives = 49/108 (45%), Gaps = 8/108 (7%)
Query: 911 EEEARKKKEKDKLRQLLKK--------ERLKAKLQRKKKKRKGSDEEDEGEEEESSSSEE 962
+E R K K+K + + E +++ L +K+ S EE+E EEE EE
Sbjct: 2201 KEAKRGDKPKEKFSSQVDEVESEEHFSEEMESLLDELEKQESLSSEEEEEREEEEEREEE 2260
Query: 963 SSSEEEEMEEEEEEEEFGPGMQEVIEQHKFEAHRWLARGKEDNELVVE 1010
EEEE +EEEE E +E E+ K + + +E E+ E
Sbjct: 2261 EVREEEEERKEEEEGEEKQVEKEEEEKKKKKKEKKKEEVQEKEEVFEE 2308
Score = 37.7 bits (86), Expect = 0.13
Identities = 29/103 (28%), Positives = 52/103 (50%), Gaps = 10/103 (9%)
Query: 911 EEEARKKKEKDKLRQLLKKERLKAKLQRKKKKRKGSDEEDEGEEEESSSSEESSSEEEE- 969
E E R +E++KL Q +K + ++ ++ KK K + + E SS S+E ++EE
Sbjct: 1484 EWEKRLLQEEEKLHQAGEKLSPEEEMLQEDKKLKWEEWKQVWENMLSSKSKEQQYKDEEE 1543
Query: 970 --------MEEEEEEEEFGPGMQEVIEQHKF-EAHRWLARGKE 1003
E EE+E++ + + E+HK+ HR AR ++
Sbjct: 1544 VTLEEEVSREGEEKEQQVTEEQRHIQEEHKWARIHRKRARAEK 1586
Score = 34.7 bits (78), Expect = 1.1
Identities = 33/127 (25%), Positives = 58/127 (45%), Gaps = 18/127 (14%)
Query: 898 LRHLVVREVDLTPEEE--ARKKKE---KDKLRQLLKKERLKAKLQRKKKKRKGSDEEDEG 952
+R ++ +E +T EE ARK E D+ +++E + L+R+ +KRK + D+
Sbjct: 2150 MRRMINKEEKMTEEESKLARKHSEVILDDEEEGGIEEEEVIPFLKRRWRKRKEAKRGDKP 2209
Query: 953 EEEESSSSEESSSEE-------------EEMEEEEEEEEFGPGMQEVIEQHKFEAHRWLA 999
+E+ SS +E SEE E+ E EEE +E E+ +
Sbjct: 2210 KEKFSSQVDEVESEEHFSEEMESLLDELEKQESLSSEEEEEREEEEEREEEEVREEEEER 2269
Query: 1000 RGKEDNE 1006
+ +E+ E
Sbjct: 2270 KEEEEGE 2276
Score = 32.7 bits (73), Expect = 4.1
Identities = 32/105 (30%), Positives = 47/105 (44%), Gaps = 9/105 (8%)
Query: 899 RHLVVREVDLTPEEEARKKKEKD---KLRQLLKKERLKAKLQRKKKKRKGSDEEDEGEEE 955
R L V+E L+ E+ KE D K +L K E+ KL RK++K +EE
Sbjct: 2102 RALFVKERRLSIEQSKLDIKEWDFSEKRSELTKDEK---KLARKQRKLANKMRRMINKEE 2158
Query: 956 ESSSSEESSSEEEEMEEEEEEEEFGPGMQEVIEQHKFEAHRWLAR 1000
+ + E + + ++EEE G +EVI F RW R
Sbjct: 2159 KMTEEESKLARKHSEVILDDEEEGGIEEEEVI---PFLKRRWRKR 2200
Score = 31.6 bits (70), Expect = 9.0
Identities = 30/120 (25%), Positives = 56/120 (46%), Gaps = 28/120 (23%)
Query: 898 LRHLVVREVDLTPEEEARKKKEKDKLRQLL------------KKERL---KAKLQRKKKK 942
+++++ ++V+ P+ E ++ +L Q L K+E L + KL +KKK
Sbjct: 1689 VKNILAQKVEELPQREQNLDWQEKELAQELEELEWDMEELSWKEEELNQEEGKLVEEKKK 1748
Query: 943 RKGSDEEDEGEEEESSSSEESSSEEEEM---EEE----------EEEEEFGPGMQEVIEQ 989
+E + E+ S E ++EEE+ E+E EEEE G +++IE+
Sbjct: 1749 LAEEEEALAWQREKLSEEETKLAQEEELLIQEKEKLAQHKEKMPEEEERLGRKREQLIEK 1808
>gi|4502057 arachidonate 5-lipoxygenase [Homo sapiens]
Length = 674
Score = 59.3 bits (142), Expect = 4e-08
Identities = 39/105 (37%), Positives = 53/105 (50%), Gaps = 5/105 (4%)
Query: 45 YEVVTATGDVRGAGTDANVFITLFGENGLSPKLQLTSKSKSAFEKGNVDVFRVRTN-NVG 103
Y V ATG AGTD ++++L G G S K L + FE+G VD + V + +G
Sbjct: 4 YTVTVATGSQWFAGTDDYIYLSLVGSAGCSEKHLLDKPFYNDFERGAVDSYDVTVDEELG 63
Query: 104 LIYKVRIEHDNTGLNASWYLDHVIVTDMKRPHLRYY-FNCNNWLS 147
I VRIE LN WYL ++ +K PH Y F C W++
Sbjct: 64 EIQLVRIEKRKYWLNDDWYLKYI---TLKTPHGDYIEFPCYRWIT 105
Score = 58.5 bits (140), Expect = 7e-08
Identities = 38/112 (33%), Positives = 52/112 (46%), Gaps = 6/112 (5%)
Query: 552 MARYHVTVCTGELEGAGTDANVYLCLFGDVGDTGERLLYNCRNNTDLFEKGNADEFTIE- 610
M Y VTV TG AGTD +YL L G G + + LL N FE+G D + +
Sbjct: 1 MPSYTVTVATGSQWFAGTDDYIYLSLVGSAGCSEKHLLDKPFYND--FERGAVDSYDVTV 58
Query: 611 SVTMRNVRRVRIRHDGKGSGSGWYLDRVLVREEGQPESDNVEFPCLRWLDKD 662
+ ++ VRI WYL + ++ P D +EFPC RW+ D
Sbjct: 59 DEELGEIQLVRIEKRKYWLNDDWYLKYITLK---TPHGDYIEFPCYRWITGD 107
Score = 51.2 bits (121), Expect = 1e-05
Identities = 33/102 (32%), Positives = 53/102 (51%), Gaps = 2/102 (1%)
Query: 2094 YEVIVTTGYEPGAGTDANVFVTIFGANGDTGKRELKQKMRNLFERGSTDRFFLET-LELG 2152
Y V V TG + AGTD +++++ G+ G + K L + N FERG+ D + + ELG
Sbjct: 4 YTVTVATGSQWFAGTDDYIYLSLVGSAGCSEKHLLDKPFYNDFERGAVDSYDVTVDEELG 63
Query: 2153 ELRKVRLEHDSSGYCSGWLVEKVEVTNTSTGVATIFNCGRWL 2194
E++ VR+E W ++ + + T G F C RW+
Sbjct: 64 EIQLVRIEKRKYWLNDDWYLKYITL-KTPHGDYIEFPCYRWI 104
Score = 47.4 bits (111), Expect = 2e-04
Identities = 31/106 (29%), Positives = 58/106 (54%), Gaps = 6/106 (5%)
Query: 1176 TFSVTIKTGVKKNAGTDANVFITLFGTQDDTGMTLLKSSKTNSDKFERDSIEIFTVETLD 1235
+++VT+ TG + AGTD ++++L G+ + LL K + FER +++ + V T+D
Sbjct: 3 SYTVTVATGSQWFAGTDDYIYLSLVGSAGCSEKHLL--DKPFYNDFERGAVDSYDV-TVD 59
Query: 1236 --LGDLWKVRLGHDNTGKAPGWFVDWVEVDAPSLGKCMTFPCGRWL 1279
LG++ VR+ W++ ++ + P G + FPC RW+
Sbjct: 60 EELGEIQLVRIEKRKYWLNDDWYLKYITLKTPH-GDYIEFPCYRWI 104
Score = 47.0 bits (110), Expect = 2e-04
Identities = 37/133 (27%), Positives = 62/133 (46%), Gaps = 10/133 (7%)
Query: 1023 TYEVQVVTGNVPKAGTDANVYLTIYGEEYGDTGERPLKKSDKSNKFEQGQTDTFTIYA-I 1081
+Y V V TG+ AGTD +YL++ G E+ L N FE+G D++ +
Sbjct: 3 SYTVTVATGSQWFAGTDDYIYLSLVGS--AGCSEKHLLDKPFYNDFERGAVDSYDVTVDE 60
Query: 1082 DLGALTKIRIRHDNTGNRAGWFLDRIDITDMNNEITYYFPCQRWLAVEED----DGQLSR 1137
+LG + +RI W+L I + + + FPC RW+ + + DG+
Sbjct: 61 ELGEIQLVRIEKRKYWLNDDWYLKYITLKTPHGDY-IEFPCYRWITGDVEVVLRDGR--A 117
Query: 1138 ELLPVDESYVLPQ 1150
+L D+ ++L Q
Sbjct: 118 KLARDDQIHILKQ 130
Score = 46.6 bits (109), Expect = 3e-04
Identities = 30/105 (28%), Positives = 53/105 (50%), Gaps = 4/105 (3%)
Query: 1462 YSVQIFTGNIPGAGTDAKVYITIYGDLGDTGERYLGKSENRTNKFERGTADTFIIEA-AD 1520
Y+V + TG+ AGTD +Y+++ G G + + L K N FERG D++ + +
Sbjct: 4 YTVTVATGSQWFAGTDDYIYLSLVGSAGCSEKHLLDKP--FYNDFERGAVDSYDVTVDEE 61
Query: 1521 LGVIYKIKLRHDNSKWCADWYVEKVEIWNDTNEDEFLFLCGRWLS 1565
LG I +++ DWY++ + + + D F C RW++
Sbjct: 62 LGEIQLVRIEKRKYWLNDDWYLKYITL-KTPHGDYIEFPCYRWIT 105
Score = 45.1 bits (105), Expect = 8e-04
Identities = 40/149 (26%), Positives = 64/149 (42%), Gaps = 18/149 (12%)
Query: 297 TYIVTVFTGDVRGAGTKSKIYLVMYGARGNKNSGKIFLEG---GVFDRGRTDIFHIELAV 353
+Y VTV TG AGT IYL + G+ G S K L+ F+RG D + + +
Sbjct: 3 SYTVTVATGSQWFAGTDDYIYLSLVGSAG--CSEKHLLDKPFYNDFERGAVDSYDVTVDE 60
Query: 354 LLSPLSRVSVGHGNVGVNRGWFCEKVVILCPFTGIQQTFPCSNW--------LDEKKADG 405
L + V + +N W+ + + + P G FPC W L + +A
Sbjct: 61 ELGEIQLVRIEKRKYWLNDDWYLKYITLKTPH-GDYIEFPCYRWITGDVEVVLRDGRAKL 119
Query: 406 LIERQLYEMVSLRKKRL----KKFPWSLW 430
+ Q++ + R+K L K++ W W
Sbjct: 120 ARDDQIHILKQHRRKELETRQKQYRWMEW 148
Score = 44.7 bits (104), Expect = 0.001
Identities = 29/105 (27%), Positives = 48/105 (45%), Gaps = 5/105 (4%)
Query: 686 YHISLKTGDVSGASTDSRVYIKLYGDKSDTIKQVLLVSDNNLKDYFERGRVDEFTLET-L 744
Y +++ TG A TD +Y+ L G + K +L D + FERG VD + +
Sbjct: 4 YTVTVATGSQWFAGTDDYIYLSLVGSAGCSEKHLL---DKPFYNDFERGAVDSYDVTVDE 60
Query: 745 NIGNINRLVIGHDSTGMHASWFLGSVQIRVPRQGKQYTFPANRWL 789
+G I + I ++ W+L + ++ P G FP RW+
Sbjct: 61 ELGEIQLVRIEKRKYWLNDDWYLKYITLKTP-HGDYIEFPCYRWI 104
Score = 43.9 bits (102), Expect = 0.002
Identities = 32/114 (28%), Positives = 52/114 (45%), Gaps = 5/114 (4%)
Query: 1824 SYTVAVKTSDILGAGTDANVFIIIFGENGDSGTLALKQSANWNKFERNNTDTFNFPDMLS 1883
SYTV V T AGTD +++ + G G S L + +N FER D+++
Sbjct: 3 SYTVTVATGSQWFAGTDDYIYLSLVGSAGCSEKHLLDKPF-YNDFERGAVDSYDVTVDEE 61
Query: 1884 LGHLCKLRVWHDNKGIFPGWHLSYVDVKDNSRDETFHFQCDCWLSKSEGDGQTV 1937
LG + +R+ + W+L Y+ +K + F C W++ GD + V
Sbjct: 62 LGEIQLVRIEKRKYWLNDDWYLKYITLK-TPHGDYIEFPCYRWIT---GDVEVV 111
Score = 42.0 bits (97), Expect = 0.007
Identities = 34/114 (29%), Positives = 57/114 (50%), Gaps = 17/114 (14%)
Query: 1308 YEITLYTSDVFAAGTDANIFIIIYGCDAVCTQQKYLCTNKREQKQF---FERKSASRFIV 1364
Y +T+ T + AGTD I++ + G A C+++ L K F FER + + V
Sbjct: 4 YTVTVATGSQWFAGTDDYIYLSLVG-SAGCSEKHLL------DKPFYNDFERGAVDSYDV 56
Query: 1365 EL-EDVGEIIEKIRIGHNNTGMNPGWHCSHVDIRRLLPDKDGAETLTFPCDRWL 1417
+ E++GEI + +RI +N W+ ++ ++ P D E FPC RW+
Sbjct: 57 TVDEELGEI-QLVRIEKRKYWLNDDWYLKYITLK--TPHGDYIE---FPCYRWI 104
Score = 40.8 bits (94), Expect = 0.015
Identities = 32/120 (26%), Positives = 59/120 (49%), Gaps = 9/120 (7%)
Query: 174 YEVKVYTGDVIGAGTDADVFINIFGEYGDTGERRLENE-KDNFEKGAEDRF-ILDAPDLG 231
Y V V TG AGTD +++++ G G + + L+ ++FE+GA D + + +LG
Sbjct: 4 YTVTVATGSQWFAGTDDYIYLSLVGSAGCSEKHLLDKPFYNDFERGAVDSYDVTVDEELG 63
Query: 232 QLMKINVGHNNKGGSAGWFLSQIVIEDIGNKRKYDFPLNRWLALDED----DG--KIQRD 285
++ + + + W+L I ++ + +FP RW+ D + DG K+ RD
Sbjct: 64 EIQLVRIEKRKYWLNDDWYLKYITLK-TPHGDYIEFPCYRWITGDVEVVLRDGRAKLARD 122
Score = 38.9 bits (89), Expect = 0.057
Identities = 31/103 (30%), Positives = 50/103 (48%), Gaps = 3/103 (2%)
Query: 1698 YEMTVWTGDVVGGGTDSNIFMTLYGINGSTEEMQLDKKKAR-FEREQNDTFIMEI-LDIA 1755
Y +TV TG GTD I+++L G G +E+ LDK FER D++ + + ++
Sbjct: 4 YTVTVATGSQWFAGTDDYIYLSLVGSAGCSEKHLLDKPFYNDFERGAVDSYDVTVDEELG 63
Query: 1756 PFTKMRIRIDGLGSRPEWFLERILLKNMNTGDLTMFYYGDWLS 1798
+RI +W+L+ I LK + GD F W++
Sbjct: 64 EIQLVRIEKRKYWLNDDWYLKYITLKTPH-GDYIEFPCYRWIT 105
Score = 35.8 bits (81), Expect = 0.48
Identities = 32/142 (22%), Positives = 60/142 (42%), Gaps = 15/142 (10%)
Query: 816 YEVEIWTGDVGGAGTSARVYMQIYGEKGKTEVLFLSSR-SKVFERASKDTFQLEA-ADVG 873
Y V + TG AGT +Y+ + G G +E L FER + D++ + ++G
Sbjct: 4 YTVTVATGSQWFAGTDDYIYLSLVGSAGCSEKHLLDKPFYNDFERGAVDSYDVTVDEELG 63
Query: 874 EVYKLRLGHTGEGFGPSWFVDTVWLR------------HLVVREVDLTPEEEARKKKEKD 921
E+ +R+ W++ + L+ + +V++ + R K +D
Sbjct: 64 EIQLVRIEKRKYWLNDDWYLKYITLKTPHGDYIEFPCYRWITGDVEVV-LRDGRAKLARD 122
Query: 922 KLRQLLKKERLKAKLQRKKKKR 943
+LK+ R K R+K+ R
Sbjct: 123 DQIHILKQHRRKELETRQKQYR 144
>gi|239508778 PREDICTED: hypothetical protein, partial [Homo
sapiens]
Length = 123
Score = 57.8 bits (138), Expect = 1e-07
Identities = 36/94 (38%), Positives = 53/94 (56%), Gaps = 6/94 (6%)
Query: 904 REVDLTPE-EEARKKKEKDKLRQLLKKERLKAKLQRKKKKRKGSDEEDEGEEEESSSSEE 962
+E + T E EE +++EK+ R+ +KE+ K K ++KK K +E E EE++ +
Sbjct: 8 KETEETEETEETEEEEEKEGKRKEKRKEKRKEKEKKKKTKETEKRKEKEEEEKKRKRKRK 67
Query: 963 SSSEEEEMEEEEEEEEFGPGMQEVIEQHKFEAHR 996
EEEE EEEEEEEE +E E+ K E R
Sbjct: 68 KKKEEEEREEEEEEEE-----EEKEEEEKEEGRR 96
Score = 57.0 bits (136), Expect = 2e-07
Identities = 33/102 (32%), Positives = 55/102 (53%), Gaps = 6/102 (5%)
Query: 905 EVDLTPEEEARKKKEKDKLRQLLKKERLKAKLQRKKKKRKGSDEEDEGEEEESSSSEESS 964
E + T EEE ++ K K+K ++ K++ K K + +K+++ +EE + + + EE
Sbjct: 15 ETEETEEEEEKEGKRKEKRKEKRKEKEKKKKTKETEKRKEKEEEEKKRKRKRKKKKEEEE 74
Query: 965 SEEEEMEEEEEEEEFGPGMQEVIEQHKFEAHRWLARGKEDNE 1006
EEEE EEEEE+EE E E+ + + R KE+ E
Sbjct: 75 REEEEEEEEEEKEE------EEKEEGRRRKKKKKRRRKEEEE 110
Score = 46.2 bits (108), Expect = 4e-04
Identities = 22/70 (31%), Positives = 42/70 (60%), Gaps = 3/70 (4%)
Query: 909 TPEEEARKKKEKDKLRQLLKKERLKAKLQRKKKKRKGSDEEDEGEEEESSSSEESSSEEE 968
T E E RK+KE+++ + +K + K K + ++++ + +EE+E EEEE +++
Sbjct: 46 TKETEKRKEKEEEEKK---RKRKRKKKKEEEEREEEEEEEEEEKEEEEKEEGRRRKKKKK 102
Query: 969 EMEEEEEEEE 978
+EEEEE+
Sbjct: 103 RRRKEEEEEK 112
Score = 45.1 bits (105), Expect = 8e-04
Identities = 19/67 (28%), Positives = 41/67 (61%)
Query: 912 EEARKKKEKDKLRQLLKKERLKAKLQRKKKKRKGSDEEDEGEEEESSSSEESSSEEEEME 971
+E K+KEK++ + K++R K K + ++++ + +EE++ EEE+ ++ +
Sbjct: 47 KETEKRKEKEEEEKKRKRKRKKKKEEEEREEEEEEEEEEKEEEEKEEGRRRKKKKKRRRK 106
Query: 972 EEEEEEE 978
EEEEE++
Sbjct: 107 EEEEEKK 113
Score = 43.5 bits (101), Expect = 0.002
Identities = 26/81 (32%), Positives = 42/81 (51%), Gaps = 13/81 (16%)
Query: 911 EEEARKKKEKDKLRQLLKKERLKAKLQRKKKKRKGSDEEDEGEEEESSSSEESSS----- 965
E+E +KK ++ + R+ ++E K K +RKKKK + EE+E EEEE EE
Sbjct: 39 EKEKKKKTKETEKRKEKEEEEKKRKRKRKKKKEEEEREEEEEEEEEEKEEEEKEEGRRRK 98
Query: 966 --------EEEEMEEEEEEEE 978
EEEE ++++ +
Sbjct: 99 KKKKRRRKEEEEEKKKKRRRK 119
Score = 39.7 bits (91), Expect = 0.033
Identities = 26/82 (31%), Positives = 37/82 (45%), Gaps = 24/82 (29%)
Query: 904 REVDLTPEEEARKKKEKDKLRQLLKKERLKAKLQRKKKKRKGSDEEDEGEEEESSSSEES 963
+E + E+E +KK K RK+KK+K +E +E EEEE EE
Sbjct: 47 KETEKRKEKEEEEKKRK-----------------RKRKKKKEEEEREEEEEEEEEEKEEE 89
Query: 964 SSEE-------EEMEEEEEEEE 978
EE ++ +EEEEE
Sbjct: 90 EKEEGRRRKKKKKRRRKEEEEE 111
Score = 35.8 bits (81), Expect = 0.48
Identities = 14/52 (26%), Positives = 37/52 (71%)
Query: 911 EEEARKKKEKDKLRQLLKKERLKAKLQRKKKKRKGSDEEDEGEEEESSSSEE 962
EEE R+++E+++ + ++E+ + + ++KKKKR+ +EE+E +++ +++
Sbjct: 71 EEEEREEEEEEEEEEKEEEEKEEGRRRKKKKKRRRKEEEEEKKKKRRRKTKK 122
Score = 31.6 bits (70), Expect = 9.0
Identities = 14/41 (34%), Positives = 29/41 (70%)
Query: 904 REVDLTPEEEARKKKEKDKLRQLLKKERLKAKLQRKKKKRK 944
RE + EEE ++++EK++ R+ KK++ + K + ++KK+K
Sbjct: 75 REEEEEEEEEEKEEEEKEEGRRRKKKKKRRRKEEEEEKKKK 115
>gi|17975763 myelin transcription factor 1 [Homo sapiens]
Length = 1121
Score = 57.4 bits (137), Expect = 2e-07
Identities = 31/79 (39%), Positives = 44/79 (55%), Gaps = 1/79 (1%)
Query: 904 REVDLTPEE-EARKKKEKDKLRQLLKKERLKAKLQRKKKKRKGSDEEDEGEEEESSSSEE 962
R DL P+ E +E K + +L E + + ++++ + +EE+E EEEE EE
Sbjct: 231 RSQDLCPQSLEDAASEESSKQKGILSHEEEDEEEEEEEEEEEEDEEEEEEEEEEEEEEEE 290
Query: 963 SSSEEEEMEEEEEEEEFGP 981
EEEE EEEEEEEE P
Sbjct: 291 EEEEEEEEEEEEEEEEAAP 309
Score = 51.2 bits (121), Expect = 1e-05
Identities = 33/89 (37%), Positives = 45/89 (50%), Gaps = 3/89 (3%)
Query: 908 LTPEEEARKKKEKDKLRQLLKKERLKAKLQRKKKKRKG---SDEEDEGEEEESSSSEESS 964
+ PE+ + + Q L + L+ + K+KG +EEDE EEEE EE
Sbjct: 216 IQPEDAEEVVEVTTERSQDLCPQSLEDAASEESSKQKGILSHEEEDEEEEEEEEEEEEDE 275
Query: 965 SEEEEMEEEEEEEEFGPGMQEVIEQHKFE 993
EEEE EEEEEEEE +E E+ + E
Sbjct: 276 EEEEEEEEEEEEEEEEEEEEEEEEEEEEE 304
Score = 36.2 bits (82), Expect = 0.37
Identities = 25/69 (36%), Positives = 31/69 (44%), Gaps = 4/69 (5%)
Query: 949 EDEGEEEESSS----SEESSSEEEEMEEEEEEEEFGPGMQEVIEQHKFEAHRWLARGKED 1004
ED EE S S E EEEE EEEEEEE+ +E E+ + E +E+
Sbjct: 241 EDAASEESSKQKGILSHEEEDEEEEEEEEEEEEDEEEEEEEEEEEEEEEEEEEEEEEEEE 300
Query: 1005 NELVVELVP 1013
E E P
Sbjct: 301 EEEEEEAAP 309
Score = 32.7 bits (73), Expect = 4.1
Identities = 23/78 (29%), Positives = 35/78 (44%)
Query: 929 KERLKAKLQRKKKKRKGSDEEDEGEEEESSSSEESSSEEEEMEEEEEEEEFGPGMQEVIE 988
+E ++ +R + S E+ EE S EE+E EEEEEEEE +E E
Sbjct: 222 EEVVEVTTERSQDLCPQSLEDAASEESSKQKGILSHEEEDEEEEEEEEEEEEDEEEEEEE 281
Query: 989 QHKFEAHRWLARGKEDNE 1006
+ + E +E+ E
Sbjct: 282 EEEEEEEEEEEEEEEEEE 299
>gi|46276863 parathymosin [Homo sapiens]
Length = 102
Score = 56.2 bits (134), Expect = 3e-07
Identities = 32/90 (35%), Positives = 50/90 (55%), Gaps = 12/90 (13%)
Query: 904 REVDLTPEEEARKKKEKDKLRQLLKKERLKAKLQRKKKKRKGSDEEDEGEEEESSSSEES 963
+ V+ E A+ KEK KE+++ K RK++K++ +EE+ G EEE + E
Sbjct: 4 KSVEAAAELSAKDLKEK--------KEKVEEKASRKERKKEVVEEEENGAEEEEEETAED 55
Query: 964 SSEEEEMEEEEEEEE----FGPGMQEVIEQ 989
EE+E EEE+EEEE GP ++ E+
Sbjct: 56 GEEEDEGEEEDEEEEEEDDEGPALKRAAEE 85
Score = 41.2 bits (95), Expect = 0.011
Identities = 23/85 (27%), Positives = 43/85 (50%), Gaps = 1/85 (1%)
Query: 901 LVVREVDLTPEEEARKKKEKDKLRQLLKKERLKAKLQRKKKKRKGSDEEDEGEEEESSSS 960
L +++ E+ K K++ ++++++E A+ + ++ G +EEDEGEEE+
Sbjct: 12 LSAKDLKEKKEKVEEKASRKERKKEVVEEEENGAEEEEEETAEDG-EEEDEGEEEDEEEE 70
Query: 961 EESSSEEEEMEEEEEEEEFGPGMQE 985
EE EEE+E P Q+
Sbjct: 71 EEDDEGPALKRAAEEEDEADPKRQK 95
>gi|148763345 cell division cycle 2-like 2 isoform 4 [Homo sapiens]
Length = 770
Score = 53.5 bits (127), Expect = 2e-06
Identities = 37/84 (44%), Positives = 47/84 (55%), Gaps = 13/84 (15%)
Query: 917 KKEKDKLRQLLKKERLKAKLQRKKKKRKGS-----------DEEDEGEEEESSSSEESSS 965
K+EK + R LL + + +RK + S +EE+E EEEE S+SEES
Sbjct: 241 KEEKMEERDLLSDLQDISDSERKTSSAESSSAESGSGSEEEEEEEEEEEEEGSTSEES-- 298
Query: 966 EEEEMEEEEEEEEFGPGMQEVIEQ 989
EEEE EEEEEEEE G +E EQ
Sbjct: 299 EEEEEEEEEEEEETGSNSEEASEQ 322
Score = 46.6 bits (109), Expect = 3e-04
Identities = 32/98 (32%), Positives = 48/98 (48%), Gaps = 1/98 (1%)
Query: 909 TPEEEARKKKEKDKLRQLLKKERLKAKLQRKKKKRKGSDEEDEGEEEESSSSEESSSEEE 968
+P R++ E R+ +K+E+++ + + SD E + ESSS+E S EE
Sbjct: 222 SPPRPPRERFELGDGRKPVKEEKMEER-DLLSDLQDISDSERKTSSAESSSAESGSGSEE 280
Query: 969 EMEEEEEEEEFGPGMQEVIEQHKFEAHRWLARGKEDNE 1006
E EEEEEEEE G +E E+ + E G E
Sbjct: 281 EEEEEEEEEEEGSTSEESEEEEEEEEEEEEETGSNSEE 318
Score = 41.6 bits (96), Expect = 0.009
Identities = 36/109 (33%), Positives = 50/109 (45%), Gaps = 13/109 (11%)
Query: 911 EEEARKKKEKDKLRQLLKKERLKAKLQRKKKKR-KGSDEEDEGEEEE------SSSSEES 963
EE+ ++ L+ + ER + + + GS+EE+E EEEE S SEE
Sbjct: 242 EEKMEERDLLSDLQDISDSERKTSSAESSSAESGSGSEEEEEEEEEEEEEGSTSEESEEE 301
Query: 964 SSEEEEMEEE---EEEEEFGPGMQEVIEQHKFEAHRWLARGKEDNELVV 1009
EEEE EEE EE +EV E+ E R E++ LVV
Sbjct: 302 EEEEEEEEEETGSNSEEASEQSAEEVSEEEMSEDEE---RENENHLLVV 347
Score = 37.7 bits (86), Expect = 0.13
Identities = 24/89 (26%), Positives = 39/89 (43%), Gaps = 1/89 (1%)
Query: 907 DLTPEEEARKKKEKDKLRQLLKKERLKAKLQRKKKKRKGSDEEDEGEEEESSSSEESSSE 966
D++ E E E + + + ++++ S+E +E EEEE EE+ S
Sbjct: 256 DISDSERKTSSAESSSAESGSGSEEEEEEEEEEEEEGSTSEESEEEEEEEEEEEEETGSN 315
Query: 967 EEEMEEEEEEEEFGPGMQEVIEQHKFEAH 995
EE E+ EE M E E+ + E H
Sbjct: 316 SEEASEQSAEEVSEEEMSE-DEERENENH 343
Score = 36.6 bits (83), Expect = 0.28
Identities = 23/91 (25%), Positives = 42/91 (46%), Gaps = 19/91 (20%)
Query: 911 EEEARKKKEKDKLRQLLKKERLKAKLQRKKKKRKGSDEEDEGEEEESSSSEESSSEEEEM 970
EEE +++E+++ ++ + + + ++++ GS+ E+ E+ SEE SE+EE
Sbjct: 279 EEEEEEEEEEEEEGSTSEESEEEEEEEEEEEEETGSNSEEASEQSAEEVSEEEMSEDEER 338
Query: 971 EEE-------------------EEEEEFGPG 982
E E E EEE G G
Sbjct: 339 ENENHLLVVPESRFDRDSGESEEAEEEVGEG 369
Score = 36.2 bits (82), Expect = 0.37
Identities = 27/128 (21%), Positives = 56/128 (43%), Gaps = 4/128 (3%)
Query: 899 RHLVVREVDLTPEEEARKKKEKDKLRQLLKKERLKAKLQRKKKKRKGSDEEDEGEEEESS 958
+H V+E + E R ++E+DK R+ + ER K + ++ R+ D ++ E +
Sbjct: 110 KHARVKERE--HERRKRHREEQDKARR--EWERQKRREMAREHSRRERDRLEQLERKRER 165
Query: 959 SSEESSSEEEEMEEEEEEEEFGPGMQEVIEQHKFEAHRWLARGKEDNELVVELVPAGKPG 1018
+ ++E+ E++E E +E + + AH R +++ P
Sbjct: 166 ERKMREQQKEQREQKERERRAEERRKEREARREVSAHHRTMREDYSDKVKASHWSRSPPR 225
Query: 1019 PERNTYEV 1026
P R +E+
Sbjct: 226 PPRERFEL 233
Score = 34.3 bits (77), Expect = 1.4
Identities = 25/76 (32%), Positives = 37/76 (48%), Gaps = 11/76 (14%)
Query: 947 DEEDEGEEEESSS-----SEESSSEEEEMEEEEEEEEFGPGMQEVIEQHKFEAHRWLARG 1001
+EE+E EEEE+ S SE+S+ E E E E+EE V+ + +F+ R
Sbjct: 302 EEEEEEEEEETGSNSEEASEQSAEEVSEEEMSEDEERENENHLLVVPESRFD------RD 355
Query: 1002 KEDNELVVELVPAGKP 1017
++E E V G P
Sbjct: 356 SGESEEAEEEVGEGTP 371
Score = 32.3 bits (72), Expect = 5.3
Identities = 18/82 (21%), Positives = 41/82 (50%)
Query: 915 RKKKEKDKLRQLLKKERLKAKLQRKKKKRKGSDEEDEGEEEESSSSEESSSEEEEMEEEE 974
+ +K K+K + KER + +R ++++ + E E ++ + E S E + +E+ E
Sbjct: 101 KDEKRKEKWKHARVKEREHERRKRHREEQDKARREWERQKRREMAREHSRRERDRLEQLE 160
Query: 975 EEEEFGPGMQEVIEQHKFEAHR 996
+ E M+E ++ + + R
Sbjct: 161 RKRERERKMREQQKEQREQKER 182
>gi|148763347 cell division cycle 2-like 2 isoform 1 [Homo sapiens]
Length = 780
Score = 53.5 bits (127), Expect = 2e-06
Identities = 37/84 (44%), Positives = 47/84 (55%), Gaps = 13/84 (15%)
Query: 917 KKEKDKLRQLLKKERLKAKLQRKKKKRKGS-----------DEEDEGEEEESSSSEESSS 965
K+EK + R LL + + +RK + S +EE+E EEEE S+SEES
Sbjct: 251 KEEKMEERDLLSDLQDISDSERKTSSAESSSAESGSGSEEEEEEEEEEEEEGSTSEES-- 308
Query: 966 EEEEMEEEEEEEEFGPGMQEVIEQ 989
EEEE EEEEEEEE G +E EQ
Sbjct: 309 EEEEEEEEEEEEETGSNSEEASEQ 332
Score = 46.6 bits (109), Expect = 3e-04
Identities = 32/98 (32%), Positives = 48/98 (48%), Gaps = 1/98 (1%)
Query: 909 TPEEEARKKKEKDKLRQLLKKERLKAKLQRKKKKRKGSDEEDEGEEEESSSSEESSSEEE 968
+P R++ E R+ +K+E+++ + + SD E + ESSS+E S EE
Sbjct: 232 SPPRPPRERFELGDGRKPVKEEKMEER-DLLSDLQDISDSERKTSSAESSSAESGSGSEE 290
Query: 969 EMEEEEEEEEFGPGMQEVIEQHKFEAHRWLARGKEDNE 1006
E EEEEEEEE G +E E+ + E G E
Sbjct: 291 EEEEEEEEEEEGSTSEESEEEEEEEEEEEEETGSNSEE 328
Score = 41.6 bits (96), Expect = 0.009
Identities = 36/109 (33%), Positives = 50/109 (45%), Gaps = 13/109 (11%)
Query: 911 EEEARKKKEKDKLRQLLKKERLKAKLQRKKKKR-KGSDEEDEGEEEE------SSSSEES 963
EE+ ++ L+ + ER + + + GS+EE+E EEEE S SEE
Sbjct: 252 EEKMEERDLLSDLQDISDSERKTSSAESSSAESGSGSEEEEEEEEEEEEEGSTSEESEEE 311
Query: 964 SSEEEEMEEE---EEEEEFGPGMQEVIEQHKFEAHRWLARGKEDNELVV 1009
EEEE EEE EE +EV E+ E R E++ LVV
Sbjct: 312 EEEEEEEEEETGSNSEEASEQSAEEVSEEEMSEDEE---RENENHLLVV 357
Score = 37.7 bits (86), Expect = 0.13
Identities = 24/89 (26%), Positives = 39/89 (43%), Gaps = 1/89 (1%)
Query: 907 DLTPEEEARKKKEKDKLRQLLKKERLKAKLQRKKKKRKGSDEEDEGEEEESSSSEESSSE 966
D++ E E E + + + ++++ S+E +E EEEE EE+ S
Sbjct: 266 DISDSERKTSSAESSSAESGSGSEEEEEEEEEEEEEGSTSEESEEEEEEEEEEEEETGSN 325
Query: 967 EEEMEEEEEEEEFGPGMQEVIEQHKFEAH 995
EE E+ EE M E E+ + E H
Sbjct: 326 SEEASEQSAEEVSEEEMSE-DEERENENH 353
Score = 36.6 bits (83), Expect = 0.28
Identities = 23/91 (25%), Positives = 42/91 (46%), Gaps = 19/91 (20%)
Query: 911 EEEARKKKEKDKLRQLLKKERLKAKLQRKKKKRKGSDEEDEGEEEESSSSEESSSEEEEM 970
EEE +++E+++ ++ + + + ++++ GS+ E+ E+ SEE SE+EE
Sbjct: 289 EEEEEEEEEEEEEGSTSEESEEEEEEEEEEEEETGSNSEEASEQSAEEVSEEEMSEDEER 348
Query: 971 EEE-------------------EEEEEFGPG 982
E E E EEE G G
Sbjct: 349 ENENHLLVVPESRFDRDSGESEEAEEEVGEG 379
Score = 36.2 bits (82), Expect = 0.37
Identities = 27/128 (21%), Positives = 56/128 (43%), Gaps = 4/128 (3%)
Query: 899 RHLVVREVDLTPEEEARKKKEKDKLRQLLKKERLKAKLQRKKKKRKGSDEEDEGEEEESS 958
+H V+E + E R ++E+DK R+ + ER K + ++ R+ D ++ E +
Sbjct: 120 KHARVKERE--HERRKRHREEQDKARR--EWERQKRREMAREHSRRERDRLEQLERKRER 175
Query: 959 SSEESSSEEEEMEEEEEEEEFGPGMQEVIEQHKFEAHRWLARGKEDNELVVELVPAGKPG 1018
+ ++E+ E++E E +E + + AH R +++ P
Sbjct: 176 ERKMREQQKEQREQKERERRAEERRKEREARREVSAHHRTMREDYSDKVKASHWSRSPPR 235
Query: 1019 PERNTYEV 1026
P R +E+
Sbjct: 236 PPRERFEL 243
Score = 34.3 bits (77), Expect = 1.4
Identities = 25/76 (32%), Positives = 37/76 (48%), Gaps = 11/76 (14%)
Query: 947 DEEDEGEEEESSS-----SEESSSEEEEMEEEEEEEEFGPGMQEVIEQHKFEAHRWLARG 1001
+EE+E EEEE+ S SE+S+ E E E E+EE V+ + +F+ R
Sbjct: 312 EEEEEEEEEETGSNSEEASEQSAEEVSEEEMSEDEERENENHLLVVPESRFD------RD 365
Query: 1002 KEDNELVVELVPAGKP 1017
++E E V G P
Sbjct: 366 SGESEEAEEEVGEGTP 381
>gi|16332372 cell division cycle 2-like 1 (PITSLRE proteins) isoform
9 [Homo sapiens]
Length = 771
Score = 53.5 bits (127), Expect = 2e-06
Identities = 37/84 (44%), Positives = 47/84 (55%), Gaps = 13/84 (15%)
Query: 917 KKEKDKLRQLLKKERLKAKLQRKKKKRKGS-----------DEEDEGEEEESSSSEESSS 965
K+EK + R LL + + +RK + S +EE+E EEEE S+SEES
Sbjct: 242 KEEKMEERDLLSDLQDISDSERKTSSAESSSAESGSGSEEEEEEEEEEEEEGSTSEES-- 299
Query: 966 EEEEMEEEEEEEEFGPGMQEVIEQ 989
EEEE EEEEEEEE G +E EQ
Sbjct: 300 EEEEEEEEEEEEETGSNSEEASEQ 323
Score = 47.4 bits (111), Expect = 2e-04
Identities = 47/187 (25%), Positives = 77/187 (41%), Gaps = 13/187 (6%)
Query: 909 TPEEEARKKKEKDKLRQLLKKERLKAKLQRKKKKRKGSDEEDEGEEEESSSSEESSSEEE 968
+P R++ E R+ +K+E+++ + + SD E + ESSS+E S EE
Sbjct: 223 SPPRPPRERFELGDGRKPVKEEKMEER-DLLSDLQDISDSERKTSSAESSSAESGSGSEE 281
Query: 969 EMEEEEEEEEFGPGMQEVIEQHKFEAHRWLARGKEDNELVVELVPAGKPGPERNTYEVQV 1028
E EEEEEEEE G +E E+ + E G E E++ EV
Sbjct: 282 EEEEEEEEEEEGSTSEESEEEEEEEEEEEEETGSNSEE-----------ASEQSAEEVSE 330
Query: 1029 VTGNVPKAGTDANVYLTIYGEEYG-DTGERPLKKSDKSNKFEQGQTDTFTIYAIDLGALT 1087
+ + + N L + + D+GE + + Q T Y D AL+
Sbjct: 331 EEMSEDEERENENHLLVVPESRFDRDSGESEEAEEEVGEGTPQSSALTEGDYVPDSPALS 390
Query: 1088 KIRIRHD 1094
I ++ +
Sbjct: 391 PIELKQE 397
Score = 40.4 bits (93), Expect = 0.019
Identities = 27/128 (21%), Positives = 56/128 (43%), Gaps = 2/128 (1%)
Query: 899 RHLVVREVDLTPEEEARKKKEKDKLRQLLKKERLKAKLQRKKKKRKGSDEEDEGEEEESS 958
+H V+E + E R ++E+DK R+ + ER K + ++ R+ D ++ E +
Sbjct: 109 KHARVKEKEREHERRKRHREEQDKARR--EWERQKRREMAREHSRRERDRLEQLERKRER 166
Query: 959 SSEESSSEEEEMEEEEEEEEFGPGMQEVIEQHKFEAHRWLARGKEDNELVVELVPAGKPG 1018
+ ++E+ E++E E +E + + AH R +++ P
Sbjct: 167 ERKMREQQKEQREQKERERRAEERRKEREARREVSAHHRTMREDYSDKVKASHWSRSPPR 226
Query: 1019 PERNTYEV 1026
P R +E+
Sbjct: 227 PPRERFEL 234
Score = 37.7 bits (86), Expect = 0.13
Identities = 24/89 (26%), Positives = 39/89 (43%), Gaps = 1/89 (1%)
Query: 907 DLTPEEEARKKKEKDKLRQLLKKERLKAKLQRKKKKRKGSDEEDEGEEEESSSSEESSSE 966
D++ E E E + + + ++++ S+E +E EEEE EE+ S
Sbjct: 257 DISDSERKTSSAESSSAESGSGSEEEEEEEEEEEEEGSTSEESEEEEEEEEEEEEETGSN 316
Query: 967 EEEMEEEEEEEEFGPGMQEVIEQHKFEAH 995
EE E+ EE M E E+ + E H
Sbjct: 317 SEEASEQSAEEVSEEEMSE-DEERENENH 344
Score = 36.6 bits (83), Expect = 0.28
Identities = 23/96 (23%), Positives = 50/96 (52%), Gaps = 9/96 (9%)
Query: 910 PEEEARKKK---EKDKLRQLLKKERLKAKLQRKKKKRKGSDEED------EGEEEESSSS 960
P++ +RK+K KD+ R+ K R+K K + +++++ +E+D E ++ +
Sbjct: 88 PQQMSRKEKVHHRKDEKRKEKKHARVKEKEREHERRKRHREEQDKARREWERQKRREMAR 147
Query: 961 EESSSEEEEMEEEEEEEEFGPGMQEVIEQHKFEAHR 996
E S E + +E+ E + E M+E ++ + + R
Sbjct: 148 EHSRRERDRLEQLERKRERERKMREQQKEQREQKER 183
>gi|16332370 cell division cycle 2-like 1 (PITSLRE proteins) isoform
8 [Homo sapiens]
Length = 780
Score = 53.5 bits (127), Expect = 2e-06
Identities = 37/84 (44%), Positives = 47/84 (55%), Gaps = 13/84 (15%)
Query: 917 KKEKDKLRQLLKKERLKAKLQRKKKKRKGS-----------DEEDEGEEEESSSSEESSS 965
K+EK + R LL + + +RK + S +EE+E EEEE S+SEES
Sbjct: 251 KEEKMEERDLLSDLQDISDSERKTSSAESSSAESGSGSEEEEEEEEEEEEEGSTSEES-- 308
Query: 966 EEEEMEEEEEEEEFGPGMQEVIEQ 989
EEEE EEEEEEEE G +E EQ
Sbjct: 309 EEEEEEEEEEEEETGSNSEEASEQ 332
Score = 47.4 bits (111), Expect = 2e-04
Identities = 47/187 (25%), Positives = 77/187 (41%), Gaps = 13/187 (6%)
Query: 909 TPEEEARKKKEKDKLRQLLKKERLKAKLQRKKKKRKGSDEEDEGEEEESSSSEESSSEEE 968
+P R++ E R+ +K+E+++ + + SD E + ESSS+E S EE
Sbjct: 232 SPPRPPRERFELGDGRKPVKEEKMEER-DLLSDLQDISDSERKTSSAESSSAESGSGSEE 290
Query: 969 EMEEEEEEEEFGPGMQEVIEQHKFEAHRWLARGKEDNELVVELVPAGKPGPERNTYEVQV 1028
E EEEEEEEE G +E E+ + E G E E++ EV
Sbjct: 291 EEEEEEEEEEEGSTSEESEEEEEEEEEEEEETGSNSEE-----------ASEQSAEEVSE 339
Query: 1029 VTGNVPKAGTDANVYLTIYGEEYG-DTGERPLKKSDKSNKFEQGQTDTFTIYAIDLGALT 1087
+ + + N L + + D+GE + + Q T Y D AL+
Sbjct: 340 EEMSEDEERENENHLLVVPESRFDRDSGESEEAEEEVGEGTPQSSALTEGDYVPDSPALS 399
Query: 1088 KIRIRHD 1094
I ++ +
Sbjct: 400 PIELKQE 406
Score = 39.7 bits (91), Expect = 0.033
Identities = 28/137 (20%), Positives = 57/137 (41%), Gaps = 11/137 (8%)
Query: 899 RHLVVREVDLTPEEEARKKKEKDKLRQLLKKERLKAKLQRKKKKRKGSD---------EE 949
+H V+E + E R ++E+DK R+ ++++ + + ++ +G+D E+
Sbjct: 109 KHARVKEKEREHERRKRHREEQDKARREWERQKRREMAREHSRRERGNDGVCLFRDRLEQ 168
Query: 950 DEGEEEESSSSEESSSEEEEMEEEEEEEEFGPGMQEVIEQHKFEAHRWLARGKEDNELVV 1009
E + E E E+ E +E E E +E + + AH R +++
Sbjct: 169 LERKRERERKMREQQKEQREQKERERRAE--ERRKEREARREVSAHHRTMREDYSDKVKA 226
Query: 1010 ELVPAGKPGPERNTYEV 1026
P P R +E+
Sbjct: 227 SHWSRSPPRPPRERFEL 243
Score = 37.7 bits (86), Expect = 0.13
Identities = 24/89 (26%), Positives = 39/89 (43%), Gaps = 1/89 (1%)
Query: 907 DLTPEEEARKKKEKDKLRQLLKKERLKAKLQRKKKKRKGSDEEDEGEEEESSSSEESSSE 966
D++ E E E + + + ++++ S+E +E EEEE EE+ S
Sbjct: 266 DISDSERKTSSAESSSAESGSGSEEEEEEEEEEEEEGSTSEESEEEEEEEEEEEEETGSN 325
Query: 967 EEEMEEEEEEEEFGPGMQEVIEQHKFEAH 995
EE E+ EE M E E+ + E H
Sbjct: 326 SEEASEQSAEEVSEEEMSE-DEERENENH 353
Score = 32.3 bits (72), Expect = 5.3
Identities = 23/101 (22%), Positives = 46/101 (45%), Gaps = 4/101 (3%)
Query: 910 PEEEARKKK---EKDKLRQLLKKERLKAKLQRKKKKRKGSDEEDEGEEE-ESSSSEESSS 965
P++ +RK+K KD+ R+ K R+K K + +++++ +E+D+ E E E +
Sbjct: 88 PQQMSRKEKVHHRKDEKRKEKKHARVKEKEREHERRKRHREEQDKARREWERQKRREMAR 147
Query: 966 EEEEMEEEEEEEEFGPGMQEVIEQHKFEAHRWLARGKEDNE 1006
E E + E +E+ + + + KE E
Sbjct: 148 EHSRRERGNDGVCLFRDRLEQLERKRERERKMREQQKEQRE 188
>gi|16332364 cell division cycle 2-like 1 (PITSLRE proteins) isoform
5 [Homo sapiens]
Length = 748
Score = 53.5 bits (127), Expect = 2e-06
Identities = 37/84 (44%), Positives = 47/84 (55%), Gaps = 13/84 (15%)
Query: 917 KKEKDKLRQLLKKERLKAKLQRKKKKRKGS-----------DEEDEGEEEESSSSEESSS 965
K+EK + R LL + + +RK + S +EE+E EEEE S+SEES
Sbjct: 219 KEEKMEERDLLSDLQDISDSERKTSSAESSSAESGSGSEEEEEEEEEEEEEGSTSEES-- 276
Query: 966 EEEEMEEEEEEEEFGPGMQEVIEQ 989
EEEE EEEEEEEE G +E EQ
Sbjct: 277 EEEEEEEEEEEEETGSNSEEASEQ 300
Score = 47.4 bits (111), Expect = 2e-04
Identities = 47/187 (25%), Positives = 77/187 (41%), Gaps = 13/187 (6%)
Query: 909 TPEEEARKKKEKDKLRQLLKKERLKAKLQRKKKKRKGSDEEDEGEEEESSSSEESSSEEE 968
+P R++ E R+ +K+E+++ + + SD E + ESSS+E S EE
Sbjct: 200 SPPRPPRERFELGDGRKPVKEEKMEER-DLLSDLQDISDSERKTSSAESSSAESGSGSEE 258
Query: 969 EMEEEEEEEEFGPGMQEVIEQHKFEAHRWLARGKEDNELVVELVPAGKPGPERNTYEVQV 1028
E EEEEEEEE G +E E+ + E G E E++ EV
Sbjct: 259 EEEEEEEEEEEGSTSEESEEEEEEEEEEEEETGSNSEE-----------ASEQSAEEVSE 307
Query: 1029 VTGNVPKAGTDANVYLTIYGEEYG-DTGERPLKKSDKSNKFEQGQTDTFTIYAIDLGALT 1087
+ + + N L + + D+GE + + Q T Y D AL+
Sbjct: 308 EEMSEDEERENENHLLVVPESRFDRDSGESEEAEEEVGEGTPQSSALTEGDYVPDSPALS 367
Query: 1088 KIRIRHD 1094
I ++ +
Sbjct: 368 PIELKQE 374
Score = 40.4 bits (93), Expect = 0.019
Identities = 27/128 (21%), Positives = 56/128 (43%), Gaps = 2/128 (1%)
Query: 899 RHLVVREVDLTPEEEARKKKEKDKLRQLLKKERLKAKLQRKKKKRKGSDEEDEGEEEESS 958
+H V+E + E R ++E+DK R+ + ER K + ++ R+ D ++ E +
Sbjct: 86 KHARVKEKEREHERRKRHREEQDKARR--EWERQKRREMAREHSRRERDRLEQLERKRER 143
Query: 959 SSEESSSEEEEMEEEEEEEEFGPGMQEVIEQHKFEAHRWLARGKEDNELVVELVPAGKPG 1018
+ ++E+ E++E E +E + + AH R +++ P
Sbjct: 144 ERKMREQQKEQREQKERERRAEERRKEREARREVSAHHRTMREDYSDKVKASHWSRSPPR 203
Query: 1019 PERNTYEV 1026
P R +E+
Sbjct: 204 PPRERFEL 211
Score = 37.7 bits (86), Expect = 0.13
Identities = 24/89 (26%), Positives = 39/89 (43%), Gaps = 1/89 (1%)
Query: 907 DLTPEEEARKKKEKDKLRQLLKKERLKAKLQRKKKKRKGSDEEDEGEEEESSSSEESSSE 966
D++ E E E + + + ++++ S+E +E EEEE EE+ S
Sbjct: 234 DISDSERKTSSAESSSAESGSGSEEEEEEEEEEEEEGSTSEESEEEEEEEEEEEEETGSN 293
Query: 967 EEEMEEEEEEEEFGPGMQEVIEQHKFEAH 995
EE E+ EE M E E+ + E H
Sbjct: 294 SEEASEQSAEEVSEEEMSE-DEERENENH 321
>gi|16332362 cell division cycle 2-like 1 (PITSLRE proteins) isoform
4 [Homo sapiens]
Length = 737
Score = 53.5 bits (127), Expect = 2e-06
Identities = 37/84 (44%), Positives = 47/84 (55%), Gaps = 13/84 (15%)
Query: 917 KKEKDKLRQLLKKERLKAKLQRKKKKRKGS-----------DEEDEGEEEESSSSEESSS 965
K+EK + R LL + + +RK + S +EE+E EEEE S+SEES
Sbjct: 208 KEEKMEERDLLSDLQDISDSERKTSSAESSSAESGSGSEEEEEEEEEEEEEGSTSEES-- 265
Query: 966 EEEEMEEEEEEEEFGPGMQEVIEQ 989
EEEE EEEEEEEE G +E EQ
Sbjct: 266 EEEEEEEEEEEEETGSNSEEASEQ 289
Score = 47.4 bits (111), Expect = 2e-04
Identities = 47/187 (25%), Positives = 77/187 (41%), Gaps = 13/187 (6%)
Query: 909 TPEEEARKKKEKDKLRQLLKKERLKAKLQRKKKKRKGSDEEDEGEEEESSSSEESSSEEE 968
+P R++ E R+ +K+E+++ + + SD E + ESSS+E S EE
Sbjct: 189 SPPRPPRERFELGDGRKPVKEEKMEER-DLLSDLQDISDSERKTSSAESSSAESGSGSEE 247
Query: 969 EMEEEEEEEEFGPGMQEVIEQHKFEAHRWLARGKEDNELVVELVPAGKPGPERNTYEVQV 1028
E EEEEEEEE G +E E+ + E G E E++ EV
Sbjct: 248 EEEEEEEEEEEGSTSEESEEEEEEEEEEEEETGSNSEE-----------ASEQSAEEVSE 296
Query: 1029 VTGNVPKAGTDANVYLTIYGEEYG-DTGERPLKKSDKSNKFEQGQTDTFTIYAIDLGALT 1087
+ + + N L + + D+GE + + Q T Y D AL+
Sbjct: 297 EEMSEDEERENENHLLVVPESRFDRDSGESEEAEEEVGEGTPQSSALTEGDYVPDSPALS 356
Query: 1088 KIRIRHD 1094
I ++ +
Sbjct: 357 PIELKQE 363
Score = 40.4 bits (93), Expect = 0.019
Identities = 27/128 (21%), Positives = 56/128 (43%), Gaps = 2/128 (1%)
Query: 899 RHLVVREVDLTPEEEARKKKEKDKLRQLLKKERLKAKLQRKKKKRKGSDEEDEGEEEESS 958
+H V+E + E R ++E+DK R+ + ER K + ++ R+ D ++ E +
Sbjct: 75 KHARVKEKEREHERRKRHREEQDKARR--EWERQKRREMAREHSRRERDRLEQLERKRER 132
Query: 959 SSEESSSEEEEMEEEEEEEEFGPGMQEVIEQHKFEAHRWLARGKEDNELVVELVPAGKPG 1018
+ ++E+ E++E E +E + + AH R +++ P
Sbjct: 133 ERKMREQQKEQREQKERERRAEERRKEREARREVSAHHRTMREDYSDKVKASHWSRSPPR 192
Query: 1019 PERNTYEV 1026
P R +E+
Sbjct: 193 PPRERFEL 200
Score = 37.7 bits (86), Expect = 0.13
Identities = 24/89 (26%), Positives = 39/89 (43%), Gaps = 1/89 (1%)
Query: 907 DLTPEEEARKKKEKDKLRQLLKKERLKAKLQRKKKKRKGSDEEDEGEEEESSSSEESSSE 966
D++ E E E + + + ++++ S+E +E EEEE EE+ S
Sbjct: 223 DISDSERKTSSAESSSAESGSGSEEEEEEEEEEEEEGSTSEESEEEEEEEEEEEEETGSN 282
Query: 967 EEEMEEEEEEEEFGPGMQEVIEQHKFEAH 995
EE E+ EE M E E+ + E H
Sbjct: 283 SEEASEQSAEEVSEEEMSE-DEERENENH 310
Score = 36.6 bits (83), Expect = 0.28
Identities = 23/96 (23%), Positives = 50/96 (52%), Gaps = 9/96 (9%)
Query: 910 PEEEARKKK---EKDKLRQLLKKERLKAKLQRKKKKRKGSDEED------EGEEEESSSS 960
P++ +RK+K KD+ R+ K R+K K + +++++ +E+D E ++ +
Sbjct: 54 PQQMSRKEKVHHRKDEKRKEKKHARVKEKEREHERRKRHREEQDKARREWERQKRREMAR 113
Query: 961 EESSSEEEEMEEEEEEEEFGPGMQEVIEQHKFEAHR 996
E S E + +E+ E + E M+E ++ + + R
Sbjct: 114 EHSRRERDRLEQLERKRERERKMREQQKEQREQKER 149
>gi|16332358 cell division cycle 2-like 1 (PITSLRE proteins) isoform
2 [Homo sapiens]
Length = 782
Score = 53.5 bits (127), Expect = 2e-06
Identities = 37/84 (44%), Positives = 47/84 (55%), Gaps = 13/84 (15%)
Query: 917 KKEKDKLRQLLKKERLKAKLQRKKKKRKGS-----------DEEDEGEEEESSSSEESSS 965
K+EK + R LL + + +RK + S +EE+E EEEE S+SEES
Sbjct: 253 KEEKMEERDLLSDLQDISDSERKTSSAESSSAESGSGSEEEEEEEEEEEEEGSTSEES-- 310
Query: 966 EEEEMEEEEEEEEFGPGMQEVIEQ 989
EEEE EEEEEEEE G +E EQ
Sbjct: 311 EEEEEEEEEEEEETGSNSEEASEQ 334
Score = 47.4 bits (111), Expect = 2e-04
Identities = 47/187 (25%), Positives = 77/187 (41%), Gaps = 13/187 (6%)
Query: 909 TPEEEARKKKEKDKLRQLLKKERLKAKLQRKKKKRKGSDEEDEGEEEESSSSEESSSEEE 968
+P R++ E R+ +K+E+++ + + SD E + ESSS+E S EE
Sbjct: 234 SPPRPPRERFELGDGRKPVKEEKMEER-DLLSDLQDISDSERKTSSAESSSAESGSGSEE 292
Query: 969 EMEEEEEEEEFGPGMQEVIEQHKFEAHRWLARGKEDNELVVELVPAGKPGPERNTYEVQV 1028
E EEEEEEEE G +E E+ + E G E E++ EV
Sbjct: 293 EEEEEEEEEEEGSTSEESEEEEEEEEEEEEETGSNSEE-----------ASEQSAEEVSE 341
Query: 1029 VTGNVPKAGTDANVYLTIYGEEYG-DTGERPLKKSDKSNKFEQGQTDTFTIYAIDLGALT 1087
+ + + N L + + D+GE + + Q T Y D AL+
Sbjct: 342 EEMSEDEERENENHLLVVPESRFDRDSGESEEAEEEVGEGTPQSSALTEGDYVPDSPALS 401
Query: 1088 KIRIRHD 1094
I ++ +
Sbjct: 402 PIELKQE 408
Score = 40.4 bits (93), Expect = 0.019
Identities = 27/128 (21%), Positives = 56/128 (43%), Gaps = 2/128 (1%)
Query: 899 RHLVVREVDLTPEEEARKKKEKDKLRQLLKKERLKAKLQRKKKKRKGSDEEDEGEEEESS 958
+H V+E + E R ++E+DK R+ + ER K + ++ R+ D ++ E +
Sbjct: 120 KHARVKEKEREHERRKRHREEQDKARR--EWERQKRREMAREHSRRERDRLEQLERKRER 177
Query: 959 SSEESSSEEEEMEEEEEEEEFGPGMQEVIEQHKFEAHRWLARGKEDNELVVELVPAGKPG 1018
+ ++E+ E++E E +E + + AH R +++ P
Sbjct: 178 ERKMREQQKEQREQKERERRAEERRKEREARREVSAHHRTMREDYSDKVKASHWSRSPPR 237
Query: 1019 PERNTYEV 1026
P R +E+
Sbjct: 238 PPRERFEL 245
Score = 37.7 bits (86), Expect = 0.13
Identities = 24/89 (26%), Positives = 39/89 (43%), Gaps = 1/89 (1%)
Query: 907 DLTPEEEARKKKEKDKLRQLLKKERLKAKLQRKKKKRKGSDEEDEGEEEESSSSEESSSE 966
D++ E E E + + + ++++ S+E +E EEEE EE+ S
Sbjct: 268 DISDSERKTSSAESSSAESGSGSEEEEEEEEEEEEEGSTSEESEEEEEEEEEEEEETGSN 327
Query: 967 EEEMEEEEEEEEFGPGMQEVIEQHKFEAH 995
EE E+ EE M E E+ + E H
Sbjct: 328 SEEASEQSAEEVSEEEMSE-DEERENENH 355
>gi|78190492 retinitis pigmentosa GTPase regulator isoform C [Homo
sapiens]
Length = 1152
Score = 52.4 bits (124), Expect = 5e-06
Identities = 48/176 (27%), Positives = 75/176 (42%), Gaps = 18/176 (10%)
Query: 911 EEEARKKKEKDKLR-----------QLLKKERLKAK---LQRKKKKRKGSDEEDEGEEEE 956
++E R+K EKDK R +L +KE K + Q +K++ +G +E E EE
Sbjct: 670 QDEEREKGEKDKGRGEMERPGEGEKELAEKEEWKKRDGEEQEQKEREQGHQKERNQEMEE 729
Query: 957 SSSSEESSSEEEEMEEEEEEEEFGPGMQEVIEQHKFEAHRWLARGKEDNELVVELVPAGK 1016
E EEEE + EEEEE+ G G +E E + E R G+ E G+
Sbjct: 730 GGEEEHGEGEEEEGDREEEEEKEGEGKEEG-EGEEVEGEREKEEGERKKEERAGKEEKGE 788
Query: 1017 PGPERNTYEVQVVTGNVPKAGTDANVYLTIYGEEYGDTGERPLKKSDKSNKFEQGQ 1072
++ E + G + V GE GER ++ + + E+G+
Sbjct: 789 EEGDQGEGEEEETEGRGEEKEEGGEVE---GGEVEEGKGEREEEEEEGEGEEEEGE 841
Score = 47.0 bits (110), Expect = 2e-04
Identities = 31/102 (30%), Positives = 54/102 (52%), Gaps = 2/102 (1%)
Query: 905 EVDLTPEEEARKKKEKDKLRQLLKKERLKAKLQRKKKKRKGSDEEDEGEEEESSSSEESS 964
E +L +EE +K+ +++ ++ ++E+ K + ++ + G +E EGEEEE EE
Sbjct: 693 EKELAEKEEWKKRDGEEQEQK--EREQGHQKERNQEMEEGGEEEHGEGEEEEGDREEEEE 750
Query: 965 SEEEEMEEEEEEEEFGPGMQEVIEQHKFEAHRWLARGKEDNE 1006
E E EE E EE G +E E+ K E +G+E+ +
Sbjct: 751 KEGEGKEEGEGEEVEGEREKEEGERKKEERAGKEEKGEEEGD 792
Score = 47.0 bits (110), Expect = 2e-04
Identities = 38/122 (31%), Positives = 59/122 (48%), Gaps = 20/122 (16%)
Query: 905 EVDLTPEEEARKKKEKDKLRQLLKKERLKAKLQRKKKKRKGSDE-------EDEGEEEES 957
E D EEE + +++ + ++ ER K + +RKK++R G +E + EGEEEE+
Sbjct: 742 EGDREEEEEKEGEGKEEGEGEEVEGEREKEEGERKKEERAGKEEKGEEEGDQGEGEEEET 801
Query: 958 SSSEESSSEEEEME---------EEEEEEEFGPGMQE----VIEQHKFEAHRWLARGKED 1004
E E E+E E EEEEE G G +E E+ + E +G+E+
Sbjct: 802 EGRGEEKEEGGEVEGGEVEEGKGEREEEEEEGEGEEEEGEGEEEEGEGEEEEGEGKGEEE 861
Query: 1005 NE 1006
E
Sbjct: 862 GE 863
Score = 44.7 bits (104), Expect = 0.001
Identities = 42/149 (28%), Positives = 64/149 (42%), Gaps = 13/149 (8%)
Query: 837 QIYGEKGKTEVLFLSSRSKVFERASKDTFQLEAADVGEVYKLRLGHTGEGFGPSWFVDTV 896
++ GE+ K E K ERA K+ E D GE + GE V+
Sbjct: 763 EVEGEREKEE-----GERKKEERAGKEEKGEEEGDQGEGEEEETEGRGEEKEEGGEVEG- 816
Query: 897 WLRHLVVREVDLTPEEEARKKKEKDKLRQLLKKERLKAKLQRKKKKRKGSDEEDEGEEEE 956
EV+ E +++E + + + E + + + ++ + KG +E +EGE EE
Sbjct: 817 -------GEVEEGKGEREEEEEEGEGEEEEGEGEEEEGEGEEEEGEGKGEEEGEEGEGEE 869
Query: 957 SSSSEESSSEEEEMEEEEEEEEFGPGMQE 985
E EEEE E E EEE G G +E
Sbjct: 870 EGEEGEGEGEEEEGEGEGEEEGEGEGEEE 898
Score = 43.5 bits (101), Expect = 0.002
Identities = 45/141 (31%), Positives = 58/141 (41%), Gaps = 11/141 (7%)
Query: 944 KGSDEEDEGEEEESSSSEESSSEEEEMEEEEEEEEFGPGMQEVIEQHKFEAHRWLARGK- 1002
+G + E EGEEEE E EEE EEE E EE G G E E+ + E G+
Sbjct: 973 EGEEGEGEGEEEEGEGEGEEEEGEEEGEEEGEGEEEGEGEGEEEEEGEVEGEVEGEEGEG 1032
Query: 1003 --EDNELVVELVPAGKPGP----ERNTYEVQVVTGNVPKAGTDANVYLTIYGEEYGDTGE 1056
E+ E E K G RN E + G + G + N GEEY +
Sbjct: 1033 EGEEEEGEEEGEEREKEGEGEENRRNREEEEEEEGKYQETGEEENERQD--GEEYKKVSK 1090
Query: 1057 RPLKKSDKSNKFEQGQTDTFT 1077
+K S K K + Q + T
Sbjct: 1091 --IKGSVKYGKHKTYQKKSVT 1109
Score = 41.2 bits (95), Expect = 0.011
Identities = 41/157 (26%), Positives = 71/157 (45%), Gaps = 10/157 (6%)
Query: 904 REVDLTPEEEARKKKEKDKLRQLLKKERLKAKLQRKKKKRKGSDEEDEGE--EEESSSSE 961
+E++ EEE + +E++ R+ +++ + K + + ++ +G E++EGE +EE + E
Sbjct: 725 QEMEEGGEEEHGEGEEEEGDREEEEEKEGEGKEEGEGEEVEGEREKEEGERKKEERAGKE 784
Query: 962 ESSSEEEEMEEEEEEEEFGPG--MQEVIEQHKFEAHRWLARGKEDNELVVELVPAGKPGP 1019
E EE + E EEEE G G +E E E +E+ E G+
Sbjct: 785 EKGEEEGDQGEGEEEETEGRGEEKEEGGEVEGGEVEEGKGEREEEEEEGEGEEEEGEGEE 844
Query: 1020 ERNTYEVQVVTGNVPKAGTDANVYLTIYGEEYGDTGE 1056
E E + G + G + GEE G+ GE
Sbjct: 845 EEGEGEEEEGEGKGEEEGEEGE------GEEEGEEGE 875
Score = 38.9 bits (89), Expect = 0.057
Identities = 27/96 (28%), Positives = 47/96 (48%)
Query: 911 EEEARKKKEKDKLRQLLKKERLKAKLQRKKKKRKGSDEEDEGEEEESSSSEESSSEEEEM 970
EEE + E+++ ++E + + + ++++ +G E+ EGE EE E EE E
Sbjct: 905 EEEGEGEGEEEEGEGKGEEEGEEGEGEGEEEEGEGEGEDGEGEGEEEEGEWEGEEEEGEG 964
Query: 971 EEEEEEEEFGPGMQEVIEQHKFEAHRWLARGKEDNE 1006
E EEE E G + E+ + E G+E+ E
Sbjct: 965 EGEEEGEGEGEEGEGEGEEEEGEGEGEEEEGEEEGE 1000
Score = 38.5 bits (88), Expect = 0.074
Identities = 29/96 (30%), Positives = 47/96 (48%), Gaps = 6/96 (6%)
Query: 911 EEEARKKKEKDKLRQLLKKERLKAKLQRKKKKRKGSDEEDEGEEEESSSSEESSSEEEEM 970
EEE ++E+ + + E + K + + ++ +G +E +EGE E EE E EE
Sbjct: 837 EEEGEGEEEEGEGEE----EEGEGKGEEEGEEGEGEEEGEEGEGE--GEEEEGEGEGEEE 890
Query: 971 EEEEEEEEFGPGMQEVIEQHKFEAHRWLARGKEDNE 1006
E E EEE G G E + + E +G+E+ E
Sbjct: 891 GEGEGEEEEGEGEGEEEGEGEGEEEEGEGKGEEEGE 926
Score = 38.1 bits (87), Expect = 0.097
Identities = 25/75 (33%), Positives = 40/75 (53%), Gaps = 1/75 (1%)
Query: 911 EEEARKKKEKDKLRQLLKKERLKAKLQRKKKKRKGSDEEDEGEEEESSSSEESSSEEEEM 970
EEE + + +++ ++E + K + + ++ +G EE+EGE E E EE E
Sbjct: 896 EEEEGEGEGEEEGEGEGEEEEGEGKGEEEGEEGEGEGEEEEGEGEGEDGEGEGEEEEGEW 955
Query: 971 EEEEEEEEFGPGMQE 985
E EEEE E G G +E
Sbjct: 956 EGEEEEGE-GEGEEE 969
Score = 36.2 bits (82), Expect = 0.37
Identities = 19/42 (45%), Positives = 22/42 (52%)
Query: 944 KGSDEEDEGEEEESSSSEESSSEEEEMEEEEEEEEFGPGMQE 985
+G +EE EGE EE E E E EEE EE G G +E
Sbjct: 894 EGEEEEGEGEGEEEGEGEGEEEEGEGKGEEEGEEGEGEGEEE 935
Score = 36.2 bits (82), Expect = 0.37
Identities = 19/67 (28%), Positives = 35/67 (52%)
Query: 911 EEEARKKKEKDKLRQLLKKERLKAKLQRKKKKRKGSDEEDEGEEEESSSSEESSSEEEEM 970
EEE ++E + + ++ ++ +++ ++ + +G +EE E E EE E
Sbjct: 1000 EEEGEGEEEGEGEGEEEEEGEVEGEVEGEEGEGEGEEEEGEEEGEEREKEGEGEENRRNR 1059
Query: 971 EEEEEEE 977
EEEEEEE
Sbjct: 1060 EEEEEEE 1066
Score = 35.8 bits (81), Expect = 0.48
Identities = 38/117 (32%), Positives = 53/117 (45%), Gaps = 9/117 (7%)
Query: 911 EEEARKKKEKDKLRQLLKKERLKAKLQRKKKKRKGSDEEDE--GEEEESSSS--EESSSE 966
EEE K E++ + E + + + + + +G +EE E GEEEE EE E
Sbjct: 914 EEEGEGKGEEEGEEGEGEGEEEEGEGEGEDGEGEGEEEEGEWEGEEEEGEGEGEEEGEGE 973
Query: 967 EEEMEEE-EEEEEFGPGMQEVIEQHKFE----AHRWLARGKEDNELVVELVPAGKPG 1018
EE E E EEEE G G +E E+ E G+E+ E VE G+ G
Sbjct: 974 GEEGEGEGEEEEGEGEGEEEEGEEEGEEEGEGEEEGEGEGEEEEEGEVEGEVEGEEG 1030
Score = 35.0 bits (79), Expect = 0.82
Identities = 20/71 (28%), Positives = 39/71 (54%), Gaps = 3/71 (4%)
Query: 911 EEEAR---KKKEKDKLRQLLKKERLKAKLQRKKKKRKGSDEEDEGEEEESSSSEESSSEE 967
EEE +++E+ ++ ++ E + + + ++ + +G + E EGE EE+ + E EE
Sbjct: 1006 EEEGEGEGEEEEEGEVEGEVEGEEGEGEGEEEEGEEEGEEREKEGEGEENRRNREEEEEE 1065
Query: 968 EEMEEEEEEEE 978
E +E EEE
Sbjct: 1066 EGKYQETGEEE 1076
Score = 33.5 bits (75), Expect = 2.4
Identities = 22/65 (33%), Positives = 32/65 (49%), Gaps = 1/65 (1%)
Query: 940 KKKRKGSDEEDEGEEEESSSSEESSSEEEEMEEEEEEEEFGPGMQEVIEQHKFEAHRWLA 999
+++ +G EE+EGE E E EEE + EEE E G G E E+ + E
Sbjct: 888 EEEGEGEGEEEEGEGEGEEEGEGEGEEEEGEGKGEEEGEEGEGEGEE-EEGEGEGEDGEG 946
Query: 1000 RGKED 1004
G+E+
Sbjct: 947 EGEEE 951
Score = 32.0 bits (71), Expect = 6.9
Identities = 44/189 (23%), Positives = 70/189 (37%), Gaps = 20/189 (10%)
Query: 904 REVDLTPEEEARKKKEKDKLRQLLKKERLKAKLQRKKKKRKGSDEEDEGEEEESSSSEES 963
+EV+ E K+K L KA++ K K G E+ + + E S
Sbjct: 604 QEVEANEENVKVHGGRKEKTEILSDDLTDKAEVSEGKAKSVGEAEDGPEGRGDGTCEEGS 663
Query: 964 SSEEEEMEEEEEEEEFGPGMQEVI-----EQHKFEAHRWLARGKEDNEL-------VVEL 1011
S E +EE E+ E G E+ E+ E W R E+ E E
Sbjct: 664 SGAEHWQDEEREKGEKDKGRGEMERPGEGEKELAEKEEWKKRDGEEQEQKEREQGHQKER 723
Query: 1012 VPAGKPGPERNTYEVQVVTGNVPK------AGTDANVYLTIYGEEYGDTGERPLKKSDKS 1065
+ G E E + G+ + G + + GE + GER KK +++
Sbjct: 724 NQEMEEGGEEEHGEGEEEEGDREEEEEKEGEGKEEGEGEEVEGEREKEEGER--KKEERA 781
Query: 1066 NKFEQGQTD 1074
K E+G+ +
Sbjct: 782 GKEEKGEEE 790
Database: hs.faa
Posted date: Aug 4, 2009 4:42 PM
Number of letters in database: 18,247,518
Number of sequences in database: 37,866
Lambda K H
0.318 0.137 0.415
Gapped
Lambda K H
0.267 0.0410 0.140
Matrix: BLOSUM62
Gap Penalties: Existence: 11, Extension: 1
Number of Hits to DB: 86,008,991
Number of Sequences: 37866
Number of extensions: 4152705
Number of successful extensions: 52068
Number of sequences better than 10.0: 30
Number of HSP's better than 10.0 without gapping: 679
Number of HSP's successfully gapped in prelim test: 387
Number of HSP's that attempted gapping in prelim test: 22554
Number of HSP's gapped (non-prelim): 14069
length of query: 2211
length of database: 18,247,518
effective HSP length: 118
effective length of query: 2093
effective length of database: 13,779,330
effective search space: 28840137690
effective search space used: 28840137690
T: 11
A: 40
X1: 16 ( 7.3 bits)
X2: 38 (14.6 bits)
X3: 64 (24.7 bits)
S1: 41 (21.7 bits)
S2: 70 (31.6 bits)
Search results were obtained with NCBI BLAST and RefSeq entries.
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Guide to the Human Genome
Copyright © 2010 by Stewart Scherer. All rights reserved.