Guide to the Human Genome
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Search of human proteins with 238859651

BLASTP 2.2.11 [Jun-05-2005]


Reference: Altschul, Stephen F., Thomas L. Madden, Alejandro A. Schaffer, 
Jinghui Zhang, Zheng Zhang, Webb Miller, and David J. Lipman (1997), 
"Gapped BLAST and PSI-BLAST: a new generation of protein database search
programs",  Nucleic Acids Res. 25:3389-3402.

Query= gi|238859651 pleckstrin homology domain containing family A
member 4 isoform 1 [Homo sapiens]
         (779 letters)

Database: hs.faa 
           37,866 sequences; 18,247,518 total letters

Searching..................................................done

                                                                 Score    E
Sequences producing significant alignments:                      (bits) Value

gi|238859651 pleckstrin homology domain containing family A memb...  1607   0.0  
gi|238859653 pleckstrin homology domain containing family A memb...  1132   0.0  
gi|239047795 pleckstrin homology domain containing, family A mem...   176   6e-44
gi|219689123 pleckstrin homology domain containing, family A mem...   143   5e-34
gi|19923493 pleckstrin homology domain containing, family A memb...   143   5e-34
gi|37595548 phosphoinositol 3-phosphate-binding protein-3 [Homo ...   143   5e-34
gi|188497618 connector enhancer of kinase suppressor of Ras 1 [H...    67   8e-11
gi|24432056 hypothetical protein LOC144717 [Homo sapiens]              65   2e-10
gi|111154092 Rho GTPase activating protein 24 isoform 1 [Homo sa...    64   7e-10
gi|194733753 phosphoinositide-binding protein PIP3-E isoform 1 [...    63   1e-09
gi|194733747 phosphoinositide-binding protein PIP3-E isoform 1 [...    63   1e-09
gi|40354212 phosphoinositide-binding protein PIP3-E isoform 2 [H...    63   1e-09
gi|148762969 myeloid/lymphoid or mixed-lineage leukemia 2 [Homo ...    61   3e-09
gi|42542379 serine/arginine repetitive matrix 1 [Homo sapiens]         60   6e-09
gi|18959210 WIRE protein [Homo sapiens]                                60   1e-08
gi|34013590 Rho GTPase activating protein 2 [Homo sapiens]             59   2e-08
gi|41349482 proline-rich protein BstNI subfamily 1 isoform 1 pre...    58   4e-08
gi|78042577 MAP7 domain containing 1 [Homo sapiens]                    58   4e-08
gi|19924099 synapsin I isoform Ia [Homo sapiens]                       56   1e-07
gi|239751637 PREDICTED: hypothetical protein FLJ22184 [Homo sapi...    55   2e-07
gi|237757326 synaptojanin 1 isoform d [Homo sapiens]                   55   2e-07
gi|112734870 hypothetical protein LOC57648 [Homo sapiens]              55   2e-07
gi|237757312 synaptojanin 1 isoform c [Homo sapiens]                   55   3e-07
gi|41393057 connector enhancer of kinase suppressor of Ras 2 [Ho...    55   3e-07
gi|110832843 TBP-associated factor 4 [Homo sapiens]                    54   4e-07
gi|54860079 nadrin isoform 1 [Homo sapiens]                            54   4e-07
gi|210032580 SET domain containing 1B [Homo sapiens]                   54   4e-07
gi|157785645 SPEG complex locus [Homo sapiens]                         54   4e-07
gi|209571537 proline-rich protein BstNI subfamily 2 [Homo sapiens]     54   4e-07
gi|41349484 proline-rich protein BstNI subfamily 1 isoform 2 pre...    54   4e-07

>gi|238859651 pleckstrin homology domain containing family A member
           4 isoform 1 [Homo sapiens]
          Length = 779

 Score = 1607 bits (4161), Expect = 0.0
 Identities = 779/779 (100%), Positives = 779/779 (100%)

Query: 1   MEGSRPRSSLSLASSASTISSLSSLSPKKPTRAVNKIHAFGKRGNALRRDPNLPVHIRGW 60
           MEGSRPRSSLSLASSASTISSLSSLSPKKPTRAVNKIHAFGKRGNALRRDPNLPVHIRGW
Sbjct: 1   MEGSRPRSSLSLASSASTISSLSSLSPKKPTRAVNKIHAFGKRGNALRRDPNLPVHIRGW 60

Query: 61  LHKQDSSGLRLWKRRWFVLSGHCLFYYKDSREESVLGSVLLPSYNIRPDGPGAPRGRRFT 120
           LHKQDSSGLRLWKRRWFVLSGHCLFYYKDSREESVLGSVLLPSYNIRPDGPGAPRGRRFT
Sbjct: 61  LHKQDSSGLRLWKRRWFVLSGHCLFYYKDSREESVLGSVLLPSYNIRPDGPGAPRGRRFT 120

Query: 121 FTAEHPGMRTYVLAADTLEDLRGWLRALGRASRAEGDDYGQPRSPARPQPGEGPGGPGGP 180
           FTAEHPGMRTYVLAADTLEDLRGWLRALGRASRAEGDDYGQPRSPARPQPGEGPGGPGGP
Sbjct: 121 FTAEHPGMRTYVLAADTLEDLRGWLRALGRASRAEGDDYGQPRSPARPQPGEGPGGPGGP 180

Query: 181 PEVSRGEEGRISESPEVTRLSRGRGRPRLLTPSPTTDLHSGLQMRRARSPDLFTPLSRPP 240
           PEVSRGEEGRISESPEVTRLSRGRGRPRLLTPSPTTDLHSGLQMRRARSPDLFTPLSRPP
Sbjct: 181 PEVSRGEEGRISESPEVTRLSRGRGRPRLLTPSPTTDLHSGLQMRRARSPDLFTPLSRPP 240

Query: 241 SPLSLPRPRSAPARRPPAPSGDTAPPARPHTPLSRIDVRPPLDWGPQRQTLSRPPTPRRG 300
           SPLSLPRPRSAPARRPPAPSGDTAPPARPHTPLSRIDVRPPLDWGPQRQTLSRPPTPRRG
Sbjct: 241 SPLSLPRPRSAPARRPPAPSGDTAPPARPHTPLSRIDVRPPLDWGPQRQTLSRPPTPRRG 300

Query: 301 PPSEAGGGKPPRSPQHWSQEPRTQAHSGSPTYLQLPPRPPGTRASMVLLPGPPLESTFHQ 360
           PPSEAGGGKPPRSPQHWSQEPRTQAHSGSPTYLQLPPRPPGTRASMVLLPGPPLESTFHQ
Sbjct: 301 PPSEAGGGKPPRSPQHWSQEPRTQAHSGSPTYLQLPPRPPGTRASMVLLPGPPLESTFHQ 360

Query: 361 SLETDTLLTKLCGQDRLLRRLQEEIDQKQEEKEQLEAALELTRQQLGQATREAGAPGRAW 420
           SLETDTLLTKLCGQDRLLRRLQEEIDQKQEEKEQLEAALELTRQQLGQATREAGAPGRAW
Sbjct: 361 SLETDTLLTKLCGQDRLLRRLQEEIDQKQEEKEQLEAALELTRQQLGQATREAGAPGRAW 420

Query: 421 GRQRLLQDRLVSVRATLCHLTQERERVWDTYSGLEQELGTLRETLEYLLHLGSPQDRVSA 480
           GRQRLLQDRLVSVRATLCHLTQERERVWDTYSGLEQELGTLRETLEYLLHLGSPQDRVSA
Sbjct: 421 GRQRLLQDRLVSVRATLCHLTQERERVWDTYSGLEQELGTLRETLEYLLHLGSPQDRVSA 480

Query: 481 QQQLWMVEDTLAGLGGPQKPPPHTEPDSPSPVLQGEESSERESLPESLELSSPRSPETDW 540
           QQQLWMVEDTLAGLGGPQKPPPHTEPDSPSPVLQGEESSERESLPESLELSSPRSPETDW
Sbjct: 481 QQQLWMVEDTLAGLGGPQKPPPHTEPDSPSPVLQGEESSERESLPESLELSSPRSPETDW 540

Query: 541 GRPPGGDKDLASPHLGLGSPRVSRASSPEGRHLPSPQLGTKAPVARPRMSAQEQLERMRR 600
           GRPPGGDKDLASPHLGLGSPRVSRASSPEGRHLPSPQLGTKAPVARPRMSAQEQLERMRR
Sbjct: 541 GRPPGGDKDLASPHLGLGSPRVSRASSPEGRHLPSPQLGTKAPVARPRMSAQEQLERMRR 600

Query: 601 NQECGRPFPRPTSPRLLTLGRTLSPARRQPDVEQRPVVGHSGAQKWLRSSGSWSSPRNTT 660
           NQECGRPFPRPTSPRLLTLGRTLSPARRQPDVEQRPVVGHSGAQKWLRSSGSWSSPRNTT
Sbjct: 601 NQECGRPFPRPTSPRLLTLGRTLSPARRQPDVEQRPVVGHSGAQKWLRSSGSWSSPRNTT 660

Query: 661 PYLPTSEGHRERVLSLSQALATEASQWHRMMTGGNLDSQGDPLPGVPLPPSDPTRQETPP 720
           PYLPTSEGHRERVLSLSQALATEASQWHRMMTGGNLDSQGDPLPGVPLPPSDPTRQETPP
Sbjct: 661 PYLPTSEGHRERVLSLSQALATEASQWHRMMTGGNLDSQGDPLPGVPLPPSDPTRQETPP 720

Query: 721 PRSPPVANSGSTGFSRRGSGRGGGPTPWGPAWDAGIAPPVLPQDEGAWPLRVTLLQSSF 779
           PRSPPVANSGSTGFSRRGSGRGGGPTPWGPAWDAGIAPPVLPQDEGAWPLRVTLLQSSF
Sbjct: 721 PRSPPVANSGSTGFSRRGSGRGGGPTPWGPAWDAGIAPPVLPQDEGAWPLRVTLLQSSF 779


>gi|238859653 pleckstrin homology domain containing family A member
           4 isoform 2 [Homo sapiens]
          Length = 583

 Score = 1132 bits (2929), Expect = 0.0
 Identities = 564/612 (92%), Positives = 567/612 (92%), Gaps = 32/612 (5%)

Query: 1   MEGSRPRSSLSLASSASTISSLSSLSPKKPTRAVNKIHAFGKRGNALRRDPNLPVHIRGW 60
           MEGSRPRSSLSLASSASTISSLSSLSPKKPTRAVNKIHAFGKRGNALRRDPNLPVHIRGW
Sbjct: 1   MEGSRPRSSLSLASSASTISSLSSLSPKKPTRAVNKIHAFGKRGNALRRDPNLPVHIRGW 60

Query: 61  LHKQDSSGLRLWKRRWFVLSGHCLFYYKDSREESVLGSVLLPSYNIRPDGPGAPRGRRFT 120
           LHKQDSSGLRLWKRRWFVLSGHCLFYYKDSREESVLGSVLLPSYNIRPDGPGAPRGRRFT
Sbjct: 61  LHKQDSSGLRLWKRRWFVLSGHCLFYYKDSREESVLGSVLLPSYNIRPDGPGAPRGRRFT 120

Query: 121 FTAEHPGMRTYVLAADTLEDLRGWLRALGRASRAEGDDYGQPRSPARPQPGEGPGGPGGP 180
           FTAEHPGMRTYVLAADTLEDLRGWLRALGRASRAEGDDYGQPRSPARPQPGEGPGGPGGP
Sbjct: 121 FTAEHPGMRTYVLAADTLEDLRGWLRALGRASRAEGDDYGQPRSPARPQPGEGPGGPGGP 180

Query: 181 PEVSRGEEGRISESPEVTRLSRGRGRPRLLTPSPTTDLHSGLQMRRARSPDLFTPLSRPP 240
           PEVSRGEEGRISESPEVTRLSRGRGRPRLLTPSPTTDLHSGLQMRRARSPDLFTPLSRPP
Sbjct: 181 PEVSRGEEGRISESPEVTRLSRGRGRPRLLTPSPTTDLHSGLQMRRARSPDLFTPLSRPP 240

Query: 241 SPLSLPRPRSAPARRPPAPSGDTAPPARPHTPLSRIDVRPPLDWGPQRQTLSRPPTPRRG 300
           SPLSLPRPRSAPARRPPAPSGDTAPPARPHTPLSRIDVRPPLDWGPQRQTLSRPPTPRRG
Sbjct: 241 SPLSLPRPRSAPARRPPAPSGDTAPPARPHTPLSRIDVRPPLDWGPQRQTLSRPPTPRRG 300

Query: 301 PPSEAGGGKPPRSPQHWSQEPRTQAHSGSPTYLQLPPRPPGTRASMVLLPGPPLESTFHQ 360
           PPSEAGGGKPPRSPQHWSQEPRTQ                         PGPPLESTFHQ
Sbjct: 301 PPSEAGGGKPPRSPQHWSQEPRTQ-------------------------PGPPLESTFHQ 335

Query: 361 SLETDTLLTKLCGQDRLLRRLQEEIDQKQEEKEQLEAALELTRQQLGQATREAGAPGRAW 420
           SLETDTLLTKLCGQDRLLRRLQEEIDQKQEEKEQLEAALELTRQQLGQATREAGAPGRAW
Sbjct: 336 SLETDTLLTKLCGQDRLLRRLQEEIDQKQEEKEQLEAALELTRQQLGQATREAGAPGRAW 395

Query: 421 GRQRLLQDRLVSVRATLCHLTQERERVWDTYSGLEQELGTLRETLEYLLHLGSPQDRVSA 480
           GRQRLLQDRLVSVRATLCHLTQERERVWDTYSGLEQELGTLRETLEYLLHLGSPQDRVSA
Sbjct: 396 GRQRLLQDRLVSVRATLCHLTQERERVWDTYSGLEQELGTLRETLEYLLHLGSPQDRVSA 455

Query: 481 QQQLWMVEDTLAGLGGPQKPPPHTEPDSPSPVLQGEESSERESLPESLELSSPRSPETDW 540
           QQQLWMVEDTLAGLGGPQKPPPHTEPDSPSPVLQGEESSERESLPESLELSSPRSPETDW
Sbjct: 456 QQQLWMVEDTLAGLGGPQKPPPHTEPDSPSPVLQGEESSERESLPESLELSSPRSPETDW 515

Query: 541 GRPPGGDKDLASPHLGLGSPRVSRASSPEGRHLPSPQLGTKAPVARPRMSAQEQLERMRR 600
           GRPPGGDKDLASPHLGLGSPRVSRASSPEGRHLPSPQLGTK+    P       L   RR
Sbjct: 516 GRPPGGDKDLASPHLGLGSPRVSRASSPEGRHLPSPQLGTKSKEHHP------LLADFRR 569

Query: 601 NQECG-RPFPRP 611
           +   G +P P P
Sbjct: 570 SPGAGSQPLPSP 581


>gi|239047795 pleckstrin homology domain containing, family A member
           7 [Homo sapiens]
          Length = 1121

 Score =  176 bits (447), Expect = 6e-44
 Identities = 127/365 (34%), Positives = 174/365 (47%), Gaps = 38/365 (10%)

Query: 5   RPRSSLSLASSASTISSLSSLSPKKPTRAVNKIHAFGKRGNALRRDPNLPVHIRGWLHKQ 64
           RP S +S  S+A T S+L +    K  ++ +K+H+FGKR  A+RR+PN+PV +RGWLHKQ
Sbjct: 115 RPSSMVSETSTAGTASTLEAKPGPKIIKSSSKVHSFGKRDQAIRRNPNVPVVVRGWLHKQ 174

Query: 65  DSSGLRLWKRRWFVLSGHCLFYYKDSREESVLGSVLLPSYNIRPDGPGAPRGRRFTFTAE 124
           DSSG+RLWKRRWFVL+ +CLFYYKDSREE+VLGS+ LPSY I P  P     R+++F A 
Sbjct: 175 DSSGMRLWKRRWFVLADYCLFYYKDSREEAVLGSIPLPSYVISPVAPEDRISRKYSFKAV 234

Query: 125 H-------------------PGMRTYVLAADTLEDLRGWLRALGRASRAEGDDYGQPRSP 165
           H                    GMRTY  +ADT ED+  W+RA+ +A++       +    
Sbjct: 235 HTGMRALIYNSSTAGSQAEQSGMRTYYFSADTQEDMNAWVRAMNQAAQV----LSRSSLK 290

Query: 166 ARPQPGEGPGGPGGPPEVSRGEEGRISESPEVTRLSRGRGRPRLLTPSPTTDLHSGLQMR 225
              +  E    P      S  E GR+   P  TR    RG   ++  +       G Q R
Sbjct: 291 RDMEKVERQAVPQANHTESCHECGRV--GPGHTRDCPHRGHDDIV--NFERQEQEGEQYR 346

Query: 226 RARSP-DLFTPLSRPPSPLSLPRPRSAPARRPPAPSGDTAPPARPHTPLSRIDVRPPLDW 284
             R P +     S+  SP S     +     P  P G  A P R     +  +   P  +
Sbjct: 347 SQRDPLEGKRDRSKARSPYSPAEEDALFMDLPTGPRGQQAQPQR-----AEKNGMLPASY 401

Query: 285 GPQRQT----LSRPPTPRRGPPSEAGGGKPPRSPQHWSQEPRTQAHSGSPTYLQLPPRPP 340
           GP  Q       R   PR  P   +         +HW++  +  + S  P    LP + P
Sbjct: 402 GPGEQNGTGGYQRAFPPRTNPEKHSQRKSNLAQVEHWARAQKGDSRS-LPLDQTLPRQGP 460

Query: 341 GTRAS 345
           G   S
Sbjct: 461 GQSLS 465



 Score =  120 bits (301), Expect = 5e-27
 Identities = 117/411 (28%), Positives = 169/411 (41%), Gaps = 44/411 (10%)

Query: 162 PRSPARPQPGEGPGGPGGPPEVS-----------RGEEGRISESPEVTRLSRGRGRPRLL 210
           P+S   P  G  P     P +               EE R      V +L   + R +  
Sbjct: 474 PKSTRHPSGGSSPPPRNLPSDYKYAQDRASHLKMSSEERRAHRDGTVWQLYEWQQRQQFR 533

Query: 211 TPSPTTDLHSGLQMRRARSPDLFTPLSRPPSPLSLPRPRS---APARRPPAPSGDTAPPA 267
             SPT  +  G       SP+ FT   R  S L +PR  S   +P+  PP       PP 
Sbjct: 534 HGSPTAPICLG-------SPE-FTDQGRSRSMLEVPRSISVPPSPSDIPPPGPPRVFPPR 585

Query: 268 RPHTPLSRIDVRPPLDWGPQRQTLSRPPTPRRGPPSEAGGGKPPRSPQ------HWSQEP 321
           RPHTP  R+ V+PP        +L   P   RG   +       RS        H    P
Sbjct: 586 RPHTPAERVTVKPPDQRRSVDISLGDSPRRARGHAVKNSSHVDRRSMPSMGYMTHTVSAP 645

Query: 322 RTQAHSGSPTYLQLPPRPPGTRASMV---LLPGPPLESTFHQSLETDTLLTKLCGQDRLL 378
                S   TYLQL          M    LL    L+       +TD  L+  C QDR+L
Sbjct: 646 SLHGKSADDTYLQLKKDLEYLDLKMTGRDLLKDRSLKPVKIAESDTDVKLSIFCEQDRVL 705

Query: 379 RRLQEEIDQKQEEKEQLEAALELTRQQLGQATREAGAPGRAWGRQRLLQDRLVSVRATLC 438
           + L+++I   +E K+QLE+ LE+  +Q+ Q   +     +   +Q+LLQ+ LV +RA L 
Sbjct: 706 QDLEDKIRALKENKDQLESVLEVLHRQMEQYRDQPQHLEKIAYQQKLLQEDLVHIRAELS 765

Query: 439 HLTQERERVWDTYSGLEQELGTLRETL-EYLLHLGSPQDRVSAQQQLWMVEDTLAGLGGP 497
             + E E  W+ Y  LE ++  L++TL E        Q++   Q+ LW +ED  AGL   
Sbjct: 766 RESTEMENAWNEYLKLENDVEQLKQTLQEQHRRAFFFQEKSQIQKDLWRIEDVTAGLSAN 825

Query: 498 QK-----------PPPHTEPDSPSPVLQGEESSERESLPESLELSSP-RSP 536
           ++           P   T P  P P +    +SE +  P+    +SP R+P
Sbjct: 826 KENFRILVESVKNPERKTVPLFPHPPVPSLSTSESKPPPQPSPPTSPVRTP 876



 Score = 33.9 bits (76), Expect = 0.59
 Identities = 33/100 (33%), Positives = 42/100 (42%), Gaps = 19/100 (19%)

Query: 230 PDLFTPLSRPPSPLSLPRPRSAPARRPPA----PSGDTAPPARPHTPLSRIDVRPPLDWG 285
           P L T  S+PP     P P ++P R P      P   T  P RPH P  R  V  PL   
Sbjct: 853 PSLSTSESKPPPQ---PSPPTSPVRTPLEVRLFPQLQTYVPYRPHPPQLR-KVTSPL--- 905

Query: 286 PQRQTLSRPPTPRRGPPSEAGGGKPPRSPQHWSQEPRTQA 325
            Q  T ++P      PP      +PP  P+ +S E +  A
Sbjct: 906 -QSPTKAKPKVEDEAPP------RPP-LPELYSPEDQPPA 937


>gi|219689123 pleckstrin homology domain containing, family A member
           5 isoform 2 [Homo sapiens]
          Length = 1105

 Score =  143 bits (361), Expect = 5e-34
 Identities = 69/147 (46%), Positives = 101/147 (68%), Gaps = 3/147 (2%)

Query: 5   RPRSSLSLASSASTIS--SLSSLSPK-KPTRAVNKIHAFGKRGNALRRDPNLPVHIRGWL 61
           RP S ++ AS+ +  S  ++  +SP  + +RA  K+H FGKR N+++R+PN PV  RGWL
Sbjct: 9   RPISMINEASNYNVTSDYAVHPMSPVGRTSRASKKVHNFGKRSNSIKRNPNAPVVRRGWL 68

Query: 62  HKQDSSGLRLWKRRWFVLSGHCLFYYKDSREESVLGSVLLPSYNIRPDGPGAPRGRRFTF 121
           +KQDS+G++LWK+RWFVLS  CLFYY+D +EE +LGS+LLPS+ I          R++ F
Sbjct: 69  YKQDSTGMKLWKKRWFVLSDLCLFYYRDEKEEGILGSILLPSFQIALLTSEDHINRKYAF 128

Query: 122 TAEHPGMRTYVLAADTLEDLRGWLRAL 148
            A HP MRTY    DT +++  W++A+
Sbjct: 129 KAAHPNMRTYYFCTDTGKEMELWMKAM 155



 Score = 68.6 bits (166), Expect = 2e-11
 Identities = 44/142 (30%), Positives = 70/142 (49%), Gaps = 7/142 (4%)

Query: 360 QSLETDTLLTKLCGQDRLLRRLQEEIDQKQEEKEQLEAALELTRQQLGQATREAGAPGRA 419
           + ++ D  L++LC QD+++  L+E++ Q  +EK  LE AL    Q++        A    
Sbjct: 562 EEVDIDAKLSRLCEQDKVVHALEEKLQQLHKEKYTLEQALLSASQEIEMHADNPAAIQTV 621

Query: 420 WGRQRLLQDRLVSVRATLCHLTQERERVWDTYSGLEQELGTLRETL-EYLLHLGSPQ--- 475
             ++  LQ+ L+S    L   T E ER W  Y  LE ++   R  + E L HLG  Q   
Sbjct: 622 VLQRDDLQNGLLSTCRELSRATAELERAWREYDKLEYDVTVTRNQMQEQLDHLGEVQTES 681

Query: 476 ---DRVSAQQQLWMVEDTLAGL 494
               R   Q++LW ++D + GL
Sbjct: 682 AGIQRAQIQKELWRIQDVMEGL 703



 Score = 30.4 bits (67), Expect = 6.6
 Identities = 12/22 (54%), Positives = 18/22 (81%)

Query: 582 APVARPRMSAQEQLERMRRNQE 603
           A   RPRM+ +EQ+ER+RR+Q+
Sbjct: 882 AESTRPRMTVEEQMERIRRHQQ 903


>gi|19923493 pleckstrin homology domain containing, family A member
           5 isoform 1 [Homo sapiens]
          Length = 1116

 Score =  143 bits (361), Expect = 5e-34
 Identities = 69/147 (46%), Positives = 101/147 (68%), Gaps = 3/147 (2%)

Query: 5   RPRSSLSLASSASTIS--SLSSLSPK-KPTRAVNKIHAFGKRGNALRRDPNLPVHIRGWL 61
           RP S ++ AS+ +  S  ++  +SP  + +RA  K+H FGKR N+++R+PN PV  RGWL
Sbjct: 117 RPISMINEASNYNVTSDYAVHPMSPVGRTSRASKKVHNFGKRSNSIKRNPNAPVVRRGWL 176

Query: 62  HKQDSSGLRLWKRRWFVLSGHCLFYYKDSREESVLGSVLLPSYNIRPDGPGAPRGRRFTF 121
           +KQDS+G++LWK+RWFVLS  CLFYY+D +EE +LGS+LLPS+ I          R++ F
Sbjct: 177 YKQDSTGMKLWKKRWFVLSDLCLFYYRDEKEEGILGSILLPSFQIALLTSEDHINRKYAF 236

Query: 122 TAEHPGMRTYVLAADTLEDLRGWLRAL 148
            A HP MRTY    DT +++  W++A+
Sbjct: 237 KAAHPNMRTYYFCTDTGKEMELWMKAM 263



 Score = 77.4 bits (189), Expect = 5e-14
 Identities = 73/285 (25%), Positives = 118/285 (41%), Gaps = 42/285 (14%)

Query: 360 QSLETDTLLTKLCGQDRLLRRLQEEIDQKQEEKEQLEAALELTRQQLGQATREAGAPGRA 419
           + ++ D  L++LC QD+++  L+E++ Q  +EK  LE AL    Q++        A    
Sbjct: 631 EEVDIDAKLSRLCEQDKVVHALEEKLQQLHKEKYTLEQALLSASQEIEMHADNPAAIQTV 690

Query: 420 WGRQRLLQDRLVSVRATLCHLTQERERVWDTYSGLEQELGTLRETL-EYLLHLGSPQ--- 475
             ++  LQ+ L+S    L   T E ER W  Y  LE ++   R  + E L HLG  Q   
Sbjct: 691 VLQRDDLQNGLLSTCRELSRATAELERAWREYDKLEYDVTVTRNQMQEQLDHLGEVQTES 750

Query: 476 ---DRVSAQQQLWMVEDTLAGLG---------------------------GPQKPPPHTE 505
               R   Q++LW ++D + GL                            GP      +E
Sbjct: 751 AGIQRAQIQKELWRIQDVMEGLSKHKQQRGTTEIGMIGSKPFSTVKYKNEGPDYRLYKSE 810

Query: 506 PDSPSPVLQGEESSERESLPES-LELSSPRSPETDWG------RPPGGDKDLASPHLGLG 558
           P+  +     E + E +S P S +E S  +      G      + P  +    + ++ L 
Sbjct: 811 PELTTVAEVDESNGEEKSEPVSEIETSVVKGSHFPVGVVPPRAKSPTPESSTIASYVTLR 870

Query: 559 SPRVSRASSPEGRHLPSPQLGTKAPVARPRMSAQEQLERMRRNQE 603
             +       E       QL   A   RPRM+ +EQ+ER+RR+Q+
Sbjct: 871 KTKKMMDLRTERPRSAVEQL-CLAESTRPRMTVEEQMERIRRHQQ 914


>gi|37595548 phosphoinositol 3-phosphate-binding protein-3 [Homo
           sapiens]
          Length = 1048

 Score =  143 bits (361), Expect = 5e-34
 Identities = 103/317 (32%), Positives = 145/317 (45%), Gaps = 26/317 (8%)

Query: 3   GSRPRSSLSLASSASTISSLSSLSPK-KPTRAVNKIHAFGKRGNALRRDPNLPVHIRGWL 61
           G RP ++ S   + + +S +    P  + TR   K  AFGKR ++++R+PN PV   GWL
Sbjct: 7   GKRPATTNSDIPNHNMVSEVPPERPSVRATRTARKAVAFGKRSHSMKRNPNAPVTKAGWL 66

Query: 62  HKQDSSGLRLWKRRWFVLSGHCLFYYKDSREESVLGSVLLPSYNIRPDGPGAPRGRRFTF 121
            KQ SSG++ W +RWFVL   CLFYYKD +EES+LGS+ L S+ +    P     R+ TF
Sbjct: 67  FKQASSGVKQWNKRWFVLVDRCLFYYKDEKEESILGSIPLLSFRVAAVQPSDNISRKHTF 126

Query: 122 TAEHPGMRTYVLAADTLEDLRGWLRALGRASRAEGDDYGQPRSPARPQPGEGPGGPGGPP 181
            AEH G+RTY  +A++ E+   W++A+G A+R +     +    A     E P     PP
Sbjct: 127 KAEHAGVRTYFFSAESPEEQEAWIQAMGEAARVQIPPAQKSVPQAVRHSHEKPDSENVPP 186

Query: 182 EVSRGEEGRIS-ESPEVTRLSRGRGRPRLLTPSPTTDLHSGLQMRRARSPDLFTPLSRPP 240
                +    S   PE    +RG G  R            G + +  R P+       PP
Sbjct: 187 SKHHQQPPHNSLPKPEPEAKTRGEGDGR------------GCE-KAERRPERPEVKKEPP 233

Query: 241 SPLSLPRPRSAPARRPPAPSGDTAPPARPHTPLSRIDVRPPLDWGPQRQTLSRP-PTPRR 299
                 +    PA   PA    +  P  P  P        P  W  Q  + SRP  T   
Sbjct: 234 -----VKANGLPAGPEPASEPGSPYPEGPRVPGGGEQPAQPNGW--QYHSPSRPGSTAFP 286

Query: 300 GPPSEAGGGK---PPRS 313
               E GG +   PPR+
Sbjct: 287 SQDGETGGHRRSFPPRT 303



 Score = 80.1 bits (196), Expect = 7e-15
 Identities = 86/347 (24%), Positives = 138/347 (39%), Gaps = 37/347 (10%)

Query: 287 QRQTLSRPPTPRRGPPSEAGGGKPPRSPQHWSQEPRTQAHSGSPTYLQLPPRPPGT---- 342
           Q ++ S P +P +G  S A    P RSP              S  + +LPPR        
Sbjct: 450 QPRSHSVPRSPSQGSYSRARIYSPVRSP--------------SARFERLPPRSEDIYADP 495

Query: 343 -----RASMVLLPGPPLESTFHQSL--------ETDTLLTKLCGQDRLLRRLQEEIDQKQ 389
                R S+     PP    F  SL        +TD LL KLC Q++++R     + Q +
Sbjct: 496 AAYVMRRSISSPKVPPYPEVFRDSLHTYKLNEQDTDKLLGKLCEQNKVVREQDRLVQQLR 555

Query: 390 EEKEQLEAALELTRQQLGQATREAGAPGRAWGRQRLLQDRLVSVRATLCHLTQERERVWD 449
            EKE LE+AL  T Q+L     +   P +   ++  LQ++L+++R  L   T        
Sbjct: 556 AEKESLESALMGTHQELEMFGSQPAYPEKLRHKKDSLQNQLINIRVELSQATTALTNSTI 615

Query: 450 TYSGLEQELGTLRETLEYLLHLGSPQDRVS--AQQQLWMVEDTLAGLGGPQKPPPHTEPD 507
            Y  LE E+  L + L   L+L +  + ++   Q+++W ++D + GL     P   T+  
Sbjct: 616 EYEHLESEVSALHDDLWEQLNLDTQNEVLNRQIQKEIWRIQDVMEGL-RKNNPSRGTDTA 674

Query: 508 SPSPVLQGEESSERESLPESLELSSPRSPETDWGRPPGGDKDLASPHLGLGSPRVSRASS 567
                L    +    S    L  +S  SP + +    G       P  G   P+ +   S
Sbjct: 675 KHRGGLGPSATYSSNSPASPLSSASLTSPLSPFSLVSGSQGSPTKP--GSNEPKANYEQS 732

Query: 568 PEGRHLPSPQLGTKAPVARPRMSAQEQLERMRRNQECGRPFPRPTSP 614
            +  H   P L T   ++      + + E+     + G   PR  SP
Sbjct: 733 KKDPHQTLP-LDTPRDISLVPTRQEVEAEKQAALNKVGVVPPRTKSP 778



 Score = 34.7 bits (78), Expect = 0.35
 Identities = 60/249 (24%), Positives = 94/249 (37%), Gaps = 32/249 (12%)

Query: 493  GLGGPQKPPPHTEPDSPSPVLQGEESSERESLPES-------LELSSPRSPETDWGRPPG 545
            GL   ++P     P      +  EE  +R    +S         L  P SP  D    P 
Sbjct: 799  GLSSQERPKSAVFPGEGKVKMSVEEQIDRMRRHQSGSMREKRRSLQLPASPAPDPSPRPA 858

Query: 546  GDKDLASPHLGLGSPRVS------RASSPEGRHLPSPQLGTKAPVARPR-MSAQEQLERM 598
                +   H  +    +S      RA  P G    +P    +  +AR R M  + Q   +
Sbjct: 859  --YKVVRRHRSIHEVDISNLEAALRAEEPGGHAYETP----REEIARLRKMELEPQHYDV 912

Query: 599  RRNQECGRPFPRPTSPRLLTL--GRTLSPAR---RQPDVEQ-RPVVGHSGAQKW--LRSS 650
              N+E   P       R + L     LSP     +Q  VE+ + ++  S  Q    +   
Sbjct: 913  DINKELSTPDKVLIPERYIDLEPDTPLSPEELKEKQKKVERIKTLIAKSSMQNVVPIGEG 972

Query: 651  GSWSSPRNTTPYLPTSEGHRERVLSLSQALATEASQWHRMMTGGNLDSQGDPLPGVPLPP 710
             S   P+++   L      +E+ + +S ALATEAS+  RM++           P  P PP
Sbjct: 973  DSVDVPQDSESQLQ----EQEKRIEISCALATEASRRGRMLSVQCATPSPPTSPASPAPP 1028

Query: 711  SDPTRQETP 719
            ++P   E+P
Sbjct: 1029 ANPLSSESP 1037


>gi|188497618 connector enhancer of kinase suppressor of Ras 1 [Homo
           sapiens]
          Length = 713

 Score = 66.6 bits (161), Expect = 8e-11
 Identities = 61/212 (28%), Positives = 91/212 (42%), Gaps = 41/212 (19%)

Query: 59  GWLHKQDSSGLRL---WKRRWFVLSGHCLFYYKDSREESVLGSVLLPSYNIRPDGPGAPR 115
           GWL  + + G  +   W+RRWFVL GH L++Y+  ++E   G + + +Y++     G  +
Sbjct: 401 GWLLLRKAPGGFMGPRWRRRWFVLKGHTLYWYRQPQDEKAEGLINVSNYSLE---SGHDQ 457

Query: 116 GRRFTFTAEHPGMRTYVLAADTLEDLRGWLRAL----------GRA---------SRAEG 156
            +++ F   H   + ++ AADTL DL  W+R L          GRA         S  E 
Sbjct: 458 KKKYVFQLTHDVYKPFIFAADTLTDLSMWVRHLITCISKYQSPGRAPPPREEDCYSETEA 517

Query: 157 DD-------YGQPRSPARP-QPGEGPGGPGGPP--EVSRGEEGRISESPE-----VTRLS 201
           +D       +    SPA+   P  G   P   P     R   G +++S E     + R  
Sbjct: 518 EDPDDEAGSHSASPSPAQAGSPLHGDTSPAATPTQRSPRTSFGSLTDSSEEALEGMVRGL 577

Query: 202 RGRGRPRLLTPSP-TTDLHSGLQMRRARSPDL 232
           R  G   L  P P T +      MRR R P L
Sbjct: 578 RQGGVSLLGQPQPLTQEQWRSSFMRRNRDPQL 609


>gi|24432056 hypothetical protein LOC144717 [Homo sapiens]
          Length = 249

 Score = 65.5 bits (158), Expect = 2e-10
 Identities = 66/231 (28%), Positives = 91/231 (39%), Gaps = 39/231 (16%)

Query: 54  PVHIRGWLHKQDSSGLRLWKRRWFVLSGHCLFYYKDSREESVLGSVLLPSYNIRPDGPGA 113
           PV   G+L+K+       + RRWFVL G+ LFY++D+     +G ++L    +       
Sbjct: 17  PVDNAGFLYKKGGRHAA-YHRRWFVLRGNMLFYFEDAASREPVGVIILEGCTVEL----V 71

Query: 114 PRGRRFTFTAEHPG--MRTYVLAADTLEDLRGWLRALGRASRAEGDDYGQPRSPARPQPG 171
                F F     G   RTYVLAA++ + + GW++AL RAS      +   R   R    
Sbjct: 72  EAAEEFAFAVRFAGTRARTYVLAAESQDAMEGWVKALSRAS------FDYLRLVVRELEQ 125

Query: 172 EGPGGPGGPPEVSRGEEGRISESPEVTRLSRGRGRPRLLTPSPTTDLHSGLQMRRARSPD 231
           +            RG  G     P+   L      P  L P P+        +  A +P 
Sbjct: 126 Q--------LAAVRGGGGMALPQPQPQSLPLPPSLPSALAPVPS--------LPSAPAPV 169

Query: 232 LFTPLSRPPSPLSLPRPR-----SAPARRPPAPSGDTAPPAR----PHTPL 273
              PL R PS L  P+       S  A   P P     PP R    PH PL
Sbjct: 170 PALPLPRRPSALP-PKENGCAVWSTEATFRPGPEPPPPPPRRRASAPHGPL 219



 Score = 35.0 bits (79), Expect = 0.27
 Identities = 26/78 (33%), Positives = 30/78 (38%), Gaps = 3/78 (3%)

Query: 240 PSPLSLPRPRSAPARRPPAPSGDTAPPARPHTPL-SRIDVRPPLDWGPQRQTLSRP--PT 296
           P P SLP P S P+   P PS  +AP   P  PL  R    PP + G    +      P 
Sbjct: 141 PQPQSLPLPPSLPSALAPVPSLPSAPAPVPALPLPRRPSALPPKENGCAVWSTEATFRPG 200

Query: 297 PRRGPPSEAGGGKPPRSP 314
           P   PP        P  P
Sbjct: 201 PEPPPPPPRRRASAPHGP 218


>gi|111154092 Rho GTPase activating protein 24 isoform 1 [Homo
           sapiens]
          Length = 748

 Score = 63.5 bits (153), Expect = 7e-10
 Identities = 36/103 (34%), Positives = 51/103 (49%), Gaps = 15/103 (14%)

Query: 59  GWLHKQDSSGLRLWKRRWFVLSGHCLFYYKDSREESVLGSVLLPSYNI-----RPDGPG- 112
           GWL KQ    ++ W  RWFVL G  L+Y+KD  E   LG++ LP   +       + PG 
Sbjct: 24  GWLRKQGGF-VKTWHTRWFVLKGDQLYYFKDEDETKPLGTIFLPGNKVSEHPCNEENPGK 82

Query: 113 -----APRGRRFTFTAEHPGMRTYVLAADTLEDLRGWLRALGR 150
                 P G R   TA H    +Y+L A T  D+  W++++ R
Sbjct: 83  FLFEVVPGGDRDRMTANH---ESYLLMASTQNDMEDWVKSIRR 122


>gi|194733753 phosphoinositide-binding protein PIP3-E isoform 1
           [Homo sapiens]
          Length = 438

 Score = 62.8 bits (151), Expect = 1e-09
 Identities = 46/189 (24%), Positives = 77/189 (40%), Gaps = 13/189 (6%)

Query: 58  RGWLHKQDSSGLRL---WKRRWFVLSGHCLFYYKDSREESVLGSVLLPSYNIRPDGPGAP 114
           +GWL+K+   G  L   WK+ W +L G  L++Y +   E   G V LP + +      + 
Sbjct: 46  QGWLYKKKEKGSFLSNKWKKFWVILKGSSLYWYSNQMAEKADGFVNLPDFTVE---RASE 102

Query: 115 RGRRFTFTAEHPGMRTYVLAADTLEDLRGWLRALGRA------SRAEGDDYGQPRSPARP 168
             ++  F   HP ++T+  AA+ ++++  WL  LG A      +  + + Y +       
Sbjct: 103 CKKKHAFKISHPQIKTFYFAAENVQEMNVWLNKLGSAVIHQESTTKDEECYSESEQEDPE 162

Query: 169 QPGEGPGGPGGPPEVSRGEEGRISESPEVTRLSRGRGRPRLLTPSPTTDLHSGLQMRRAR 228
              E P  P      S   +   S SP ++  S           +P++   S L   R  
Sbjct: 163 IAAETPPPPHASQTQSLTAQQASSSSPSLSGTSYSFSSLENTVKTPSS-FPSSLSKERQS 221

Query: 229 SPDLFTPLS 237
            PD    LS
Sbjct: 222 LPDTVNSLS 230


>gi|194733747 phosphoinositide-binding protein PIP3-E isoform 1
           [Homo sapiens]
          Length = 438

 Score = 62.8 bits (151), Expect = 1e-09
 Identities = 46/189 (24%), Positives = 77/189 (40%), Gaps = 13/189 (6%)

Query: 58  RGWLHKQDSSGLRL---WKRRWFVLSGHCLFYYKDSREESVLGSVLLPSYNIRPDGPGAP 114
           +GWL+K+   G  L   WK+ W +L G  L++Y +   E   G V LP + +      + 
Sbjct: 46  QGWLYKKKEKGSFLSNKWKKFWVILKGSSLYWYSNQMAEKADGFVNLPDFTVE---RASE 102

Query: 115 RGRRFTFTAEHPGMRTYVLAADTLEDLRGWLRALGRA------SRAEGDDYGQPRSPARP 168
             ++  F   HP ++T+  AA+ ++++  WL  LG A      +  + + Y +       
Sbjct: 103 CKKKHAFKISHPQIKTFYFAAENVQEMNVWLNKLGSAVIHQESTTKDEECYSESEQEDPE 162

Query: 169 QPGEGPGGPGGPPEVSRGEEGRISESPEVTRLSRGRGRPRLLTPSPTTDLHSGLQMRRAR 228
              E P  P      S   +   S SP ++  S           +P++   S L   R  
Sbjct: 163 IAAETPPPPHASQTQSLTAQQASSSSPSLSGTSYSFSSLENTVKTPSS-FPSSLSKERQS 221

Query: 229 SPDLFTPLS 237
            PD    LS
Sbjct: 222 LPDTVNSLS 230


>gi|40354212 phosphoinositide-binding protein PIP3-E isoform 2 [Homo
           sapiens]
          Length = 437

 Score = 62.8 bits (151), Expect = 1e-09
 Identities = 46/189 (24%), Positives = 77/189 (40%), Gaps = 13/189 (6%)

Query: 58  RGWLHKQDSSGLRL---WKRRWFVLSGHCLFYYKDSREESVLGSVLLPSYNIRPDGPGAP 114
           +GWL+K+   G  L   WK+ W +L G  L++Y +   E   G V LP + +      + 
Sbjct: 45  QGWLYKKKEKGSFLSNKWKKFWVILKGSSLYWYSNQMAEKADGFVNLPDFTVE---RASE 101

Query: 115 RGRRFTFTAEHPGMRTYVLAADTLEDLRGWLRALGRA------SRAEGDDYGQPRSPARP 168
             ++  F   HP ++T+  AA+ ++++  WL  LG A      +  + + Y +       
Sbjct: 102 CKKKHAFKISHPQIKTFYFAAENVQEMNVWLNKLGSAVIHQESTTKDEECYSESEQEDPE 161

Query: 169 QPGEGPGGPGGPPEVSRGEEGRISESPEVTRLSRGRGRPRLLTPSPTTDLHSGLQMRRAR 228
              E P  P      S   +   S SP ++  S           +P++   S L   R  
Sbjct: 162 IAAETPPPPHASQTQSLTAQQASSSSPSLSGTSYSFSSLENTVKTPSS-FPSSLSKERQS 220

Query: 229 SPDLFTPLS 237
            PD    LS
Sbjct: 221 LPDTVNSLS 229


>gi|148762969 myeloid/lymphoid or mixed-lineage leukemia 2 [Homo
           sapiens]
          Length = 5537

 Score = 61.2 bits (147), Expect = 3e-09
 Identities = 74/232 (31%), Positives = 84/232 (36%), Gaps = 48/232 (20%)

Query: 164 SPARPQPGEGPGGPGGPPEVSR----GEEGRISESPEVTRLSRGRGRPRL--------LT 211
           SP  P P E P  P  PPE SR     EE   S  PE   LSR      L        L+
Sbjct: 447 SPLSPPPEESPTSP--PPEASRLSPPPEELPASPLPEALHLSRPLEESPLSPPPEESPLS 504

Query: 212 PSPTTDLHSGLQM-------RRARSPDLFTPLSRPP--SPLS--------LPRPRSAPAR 254
           P P +   S L+            SP L TPLS PP  SPLS         P P   P  
Sbjct: 505 PPPESSPFSPLEESPLSPPEESPPSPALETPLSPPPEASPLSPPFEESPLSPPPEELPTS 564

Query: 255 RPPAPSGDTAPPARPHTPLSRIDVRPPLDWGPQRQTLSRP-------PTPRR---GPPSE 304
            PP  S  + PP    +P+S      P+   P+   L  P       P P      PP E
Sbjct: 565 PPPEASRLSPPP--EESPMSPPPEESPMSPPPEASRLFPPFEESPLSPPPEESPLSPPPE 622

Query: 305 AGGGKPPRSPQHWSQEPRTQAHSGSPTYLQLPPRPPGTRASMVLLPGPPLES 356
           A    PP      S  P     S  P   +L P P  +R     L  PP ES
Sbjct: 623 ASRLSPPPEDSPMSPPPEESPMSPPPEVSRLSPLPVVSR-----LSPPPEES 669



 Score = 53.9 bits (128), Expect = 6e-07
 Identities = 138/568 (24%), Positives = 192/568 (33%), Gaps = 88/568 (15%)

Query: 164  SPARPQPGEGPGGPGGPPEVSRGEEGRISESPEVTRLSRGRGRPRLLTPSPTTDLHSGLQ 223
            SP  P   E P  P  PPE     E   S  PE +RLS       +  P   + +    +
Sbjct: 543  SPLSPPFEESPLSP--PPE-----ELPTSPPPEASRLSPPPEESPMSPPPEESPMSPPPE 595

Query: 224  MRRARSPDLFTPLSRPP--SPLSLPRPRSAPARRPPAPSGDTAPPAR-PHTPLSRIDVRP 280
              R   P   +PLS PP  SPLS P P ++    PP  S  + PP   P +P   +    
Sbjct: 596  ASRLFPPFEESPLSPPPEESPLS-PPPEASRLSPPPEDSPMSPPPEESPMSPPPEVSRLS 654

Query: 281  PLDWGPQRQTLSRPP--TPRRGPPSEAGGGKPPRSPQHWSQEPRTQAHSGSPTYLQLPPR 338
            PL   P    LS PP  +P   PP E+    PP + +     P  +    SP     P  
Sbjct: 655  PL---PVVSRLSPPPEESPLSPPPEESPTSPPPEASR---LSPPPEDSPTSPPPEDSPAS 708

Query: 339  PPGTRASMVLLPGPPLESTFHQSLETDTLLTKLCGQDRLLRRLQEEIDQKQEEKEQLEAA 398
            PP   + M L   P  ES      E   L  +  G     R  +  +  + EE      A
Sbjct: 709  PPPEDSLMSL---PLEESPLLPLPEEPQLCPRSEGPHLSPRPEEPHLSPRPEEPHLSPQA 765

Query: 399  LELTRQQLGQATREAGAPGRAWGRQRLLQDRLVSVRATLCHLTQERERVWDTYSGLEQEL 458
             E       +       P          ++  +S +A   HL+ + E +  +    E  L
Sbjct: 766  EEPHLSPQPEEPCLCAVP----------EEPHLSPQAEGPHLSPQPEELHLSPQTEEPHL 815

Query: 459  GTLRETLEYLLHLGSPQDRVSAQQQLWMVEDTLAGLGGPQKPPPHTEPDSPSPVLQGEES 518
              + E  E  L     +  +S Q +    E  L+    P+    H  P+   P L    S
Sbjct: 816  SPVPE--EPCLSPQPEESHLSPQSE----EPCLS----PRPEESHLSPELEKPPL----S 861

Query: 519  SERESLPESLELSSPRSPETDWGRPPGGDKDLASPHLGLGSPRVSRASSPEGRHLPSPQL 578
               E  PE  E     +PE     PP G+  L+     LG P +S    P     P P+ 
Sbjct: 862  PRPEKPPE--EPGQCPAPEELPLFPPPGEPSLSPL---LGEPALSEPGEPP--LSPLPEE 914

Query: 579  GTKAPVARPRMSAQEQLERMRRNQECGRPFPRPTSPRLLTLGRTLSPARRQPDVEQRPVV 638
               +P   P +S Q                P P  P L  +    +P    P  E     
Sbjct: 915  LPLSPSGEPSLSPQLMP-------------PDPLPPPLSPIITAAAPPALSPLGELEYPF 961

Query: 639  GHSGAQKWLRSSGSWSSPRNTTPYLPTSEGHRERVLSLSQALATEASQWHRMMTGGNLDS 698
            G  G           ++P   TP  P  E           A  T+      M+       
Sbjct: 962  GAKGDSD---PESPLAAPILETPISPPPE-----------ANCTDPEPVPPMIL------ 1001

Query: 699  QGDPLPGVPLPPSDPTRQETPPPRSPPV 726
               P PG P+ P+ P   E  PP+  P+
Sbjct: 1002 --PPSPGSPVGPASPILMEPLPPQCSPL 1027



 Score = 42.7 bits (99), Expect = 0.001
 Identities = 54/176 (30%), Positives = 69/176 (39%), Gaps = 42/176 (23%)

Query: 162  PRSPAR----PQPGEGPGGPGGPPEVSRGEEGRISES-PE-------------------- 196
            P SPAR    P+ GE  G PGG     +G EG+  ++ P+                    
Sbjct: 4820 PESPARAGTEPKKGEAEG-PGGK---EKGLEGKSPDTGPDWLKQFDAVLPGYTLKSQLDI 4875

Query: 197  VTRLSRGRGRPRLLTPSPTTDLHSGLQMRRARSPDLFTPLSRPPSPLSLPRPRSAPARRP 256
            ++ L +    P   T    T   S L +R+  +P    P S PPSPL+ P P S P    
Sbjct: 4876 LSLLKQESPAPEPPTQHSYTYNVSNLDVRQLSAPPPEEP-SPPPSPLA-PSPASPPTE-- 4931

Query: 257  PAPSGDTAPPARPHTPLSRIDVRPPLDWGPQRQTLSRPPTPRRGPPSEAGGGKPPR 312
            P     T P A P  P        PL   P+    S  P PR  PP E    +PPR
Sbjct: 4932 PLVELPTEPLAEPPVPSPL-----PLASSPE----SARPKPRARPPEEGEDSRPPR 4978



 Score = 42.0 bits (97), Expect = 0.002
 Identities = 68/241 (28%), Positives = 91/241 (37%), Gaps = 68/241 (28%)

Query: 157  DDYGQPRSP-----ARPQ-PGEGPGGPGGPPEVSRGEEGRISESPEVTRLSRGRGRPRLL 210
            D + +PR P     A P+ PG G GG    P +S    G   ++ EV +   G   P   
Sbjct: 2242 DPFLKPRCPSLDNLAVPESPGVG-GGKASEPLLSPPPFGESRKALEVKKEELGASSPSYG 2300

Query: 211  TP------SPTTDLH-SGLQMRRARSPDLF-TPLS---------------RP-------- 239
             P      SP++  H  GL+++   +PD+F  PL+               RP        
Sbjct: 2301 PPNLGFVDSPSSGTHLGGLELK---TPDVFKAPLTPRASQVEPQSPGLGLRPQEPPPAQA 2357

Query: 240  --PSPLSLP-------------RPRSAPARRPPAPSGDTAPPAR--PHTPLSRIDVRPPL 282
              PSP S P             +P   P  +PP P    A P R  P  P SR+      
Sbjct: 2358 LAPSPPSHPDIFRPGSYTDPYAQPPLTPRPQPPPPESCCALPPRSLPSDPFSRVPA---- 2413

Query: 283  DWGPQRQTLSRPPTPRRGPPSEAGGGKP--PR--SPQHWSQEPRTQAHSGSPTYLQLPPR 338
               PQ Q+ S+ P   R   +EA    P  PR  SP  +S+ P           L  PPR
Sbjct: 2414 --SPQSQSSSQSPLTPRPLSAEAFCPSPVTPRFQSPDPYSRPPSRPQSRDPFAPLHKPPR 2471

Query: 339  P 339
            P
Sbjct: 2472 P 2472



 Score = 41.6 bits (96), Expect = 0.003
 Identities = 42/120 (35%), Positives = 50/120 (41%), Gaps = 15/120 (12%)

Query: 235 PLSRPP--SPLSLPRPRSAPARRPPAPSGDTAPPAR-PHTPL------SRIDVRPPLDWG 285
           PL  PP  SPLS P P  +P   PP  S  + PP   P +PL      SR     PL   
Sbjct: 439 PLLPPPEESPLS-PPPEESPTSPPPEASRLSPPPEELPASPLPEALHLSRPLEESPLSPP 497

Query: 286 PQRQTLSRPPTPRRGPPSEAGGGKPP-RSPQHWSQE----PRTQAHSGSPTYLQLPPRPP 340
           P+   LS PP      P E     PP  SP   + E    P  +A   SP + + P  PP
Sbjct: 498 PEESPLSPPPESSPFSPLEESPLSPPEESPPSPALETPLSPPPEASPLSPPFEESPLSPP 557



 Score = 41.6 bits (96), Expect = 0.003
 Identities = 60/222 (27%), Positives = 80/222 (36%), Gaps = 30/222 (13%)

Query: 153 RAEGDDYGQPRSPARPQPGEGPGGPGGPPEVSRGEEGRISESPEVTRLSRGRGRPRL--- 209
           R+EG     P    RP+       P  P    + EE  +S  PE   L      P L   
Sbjct: 737 RSEG-----PHLSPRPEEPHLSPRPEEPHLSPQAEEPHLSPQPEEPCLCAVPEEPHLSPQ 791

Query: 210 -----LTPSPTTDLHSGLQMRRAR-SPDLFTPLSRPPSPLSLPRPRSAPARRPPAPSGDT 263
                L+P P  +LH   Q      SP    P   P    S   P+S      P P    
Sbjct: 792 AEGPHLSPQPE-ELHLSPQTEEPHLSPVPEEPCLSPQPEESHLSPQSEEPCLSPRPEESH 850

Query: 264 APPARPHTPLSRIDVRPPLDWG----PQRQTLSRPP-----TPRRGPPSEAGGGKPPRSP 314
             P     PLS    +PP + G    P+   L  PP     +P  G P+ +  G+PP SP
Sbjct: 851 LSPELEKPPLSPRPEKPPEEPGQCPAPEELPLFPPPGEPSLSPLLGEPALSEPGEPPLSP 910

Query: 315 QHWSQEPRTQAHSGSPTYLQ--LPPRP-PGTRASMVLLPGPP 353
                E    + SG P+     +PP P P   + ++    PP
Sbjct: 911 ---LPEELPLSPSGEPSLSPQLMPPDPLPPPLSPIITAAAPP 949



 Score = 40.4 bits (93), Expect = 0.006
 Identities = 51/213 (23%), Positives = 78/213 (36%), Gaps = 24/213 (11%)

Query: 226  RARSPDLFTPLSRPPSPLSLPRPRSA---PARRPPAPSGDTAPPARPHTPLSRIDVRPPL 282
            R   P    P  RPP       PR A   P  +P    G   P     +P       P +
Sbjct: 3087 RGVEPGPLGPEERPPPAADASEPRLASVLPEVKPKVEEGGRHP-----SPCQFTIATPKV 3141

Query: 283  DWGPQRQTLS---RPPTPRRGPPSEAGGGKPPRSPQHWSQEPRTQAHSGSPTYLQLPPRP 339
            +  P   +L    +P     G      G  P  S  H +++    A  G P +L  P   
Sbjct: 3142 EPAPAANSLGLGLKPGQSMMGSRDTRMGTGPFSSSGHTAEKASFGATGGPPAHLLTPSPL 3201

Query: 340  PGTRASMVL-----------LPGPPLESTFH-QSLETDTLLTKL-CGQDRLLRRLQEEID 386
             G   S +L           LPG P  S      +E+  + ++L    + LL   ++E+ 
Sbjct: 3202 SGPGGSSLLEKFELESGALTLPGGPAASGDELDKMESSLVASELPLLIEDLLEHEKKELQ 3261

Query: 387  QKQEEKEQLEAALELTRQQLGQATREAGAPGRA 419
            +KQ+   QL+ A +  +QQ   +   A  P +A
Sbjct: 3262 KKQQLSAQLQPAQQQQQQQQQHSLLSAPGPAQA 3294



 Score = 39.3 bits (90), Expect = 0.014
 Identities = 66/288 (22%), Positives = 119/288 (41%), Gaps = 61/288 (21%)

Query: 379  RRLQEEIDQKQEEKEQLEAALELTRQQLGQATREAGAPGRAWGRQRLLQDRLVSVRATLC 438
            ++LQ++   +Q++++QL+   +L +QQL Q  ++          Q+L Q +   ++    
Sbjct: 3904 QQLQQQQQLQQQQQQQLQQQQQLQQQQLQQQQQQ----------QQLQQQQQQQLQQQQQ 3953

Query: 439  HLTQERERVWDTY--SGLEQELGTLRETLEYLLHLGSPQDRVSAQQQLWMVEDTLAGLGG 496
             L Q++++    +     +Q++G L ++   L    SPQ     QQQ    +    G G 
Sbjct: 3954 QLQQQQQQQQQQFQQQQQQQQMGLLNQSRTLL----SPQQ----QQQ----QQVALGPGM 4001

Query: 497  PQKPPPH-TEPDSPSPVLQGEESSERESLPESLELSSPRSPETDWGRPPGGDKDLASPHL 555
            P KP  H + P +  P L      E+ ++  ++   +   P T  G P           L
Sbjct: 4002 PAKPLQHFSSPGALGPTLL-LTGKEQNTVDPAVSSEATEGPSTHQGGP-----------L 4049

Query: 556  GLGSPRVSRASSPEGRHLPSPQLGTKAPVARPRMSAQEQLERMRRNQECGRPFPRPTSPR 615
             +G+   S A+ P                 +P +S   QL  ++      +P P+P+S +
Sbjct: 4050 AIGTTPESMATEP--------------GEVKPSLSGDSQLLLVQ-----PQPQPQPSSLQ 4090

Query: 616  LLTLGRTLSPARRQPDVEQRPVVGHSGAQKWLRSSGSWSSPRNTTPYL 663
            L    R   P ++Q  V      G  G       SGS SS  ++ P+L
Sbjct: 4091 LQPPLRL--PGQQQQQVSLLHTAG--GGSHGQLGSGS-SSEASSVPHL 4133



 Score = 38.5 bits (88), Expect = 0.024
 Identities = 72/264 (27%), Positives = 99/264 (37%), Gaps = 40/264 (15%)

Query: 165  PARPQP----GEGPGGPGGPPEVSRGE---EGRISESPEVTRLSRGRGRP-------RLL 210
            P +P P    G+G  G G  P V +     +G ++++P++  LS  + +        R L
Sbjct: 4172 PPKPGPVLQSGQGLPGVGIMPTVGQLRAQLQGVLAKNPQLRHLSPQQQQQLQALLMQRQL 4231

Query: 211  TPSPTTDLHSGLQMRRARSPDLFTPLSRPPSPLSLPRPRSAPARRPPAPSGDTAPPARPH 270
              S         Q    ++  L   L   P     P P++ P +   A      PP  P 
Sbjct: 4232 QQSQAVRQTPPYQEPGTQTSPLQGLLGCQPQLGGFPGPQTGPLQELGAGPRPQGPPRLPA 4291

Query: 271  TPLSRIDVRPPLDWGPQRQTLSRPPTPRRGPPSEAGGGKPPRSPQHWSQEPRTQAHSGSP 330
             P   +   P L  GP        PTP   PPS       P+ P+  SQ P     S  P
Sbjct: 4292 PP-GALSTGPVL--GPVH------PTP---PPSS------PQEPKRPSQLPSPS--SQLP 4331

Query: 331  TYLQLPPRPPGT-RASMVLLPGPPLESTFHQSLETDTLLTKLCGQDRLLRRLQEEIDQKQ 389
            T  QLPP  PGT +     L  PP   +   +   DTL +K  G       L E   QK 
Sbjct: 4332 TEAQLPPTHPGTPKPQGPTLEPPPGRVSPAAAQLADTLFSKGLGPWDPPDNLAE--TQKP 4389

Query: 390  EEKEQLEAALELTRQQLGQATREA 413
            E+   +   L+   Q  GQ   EA
Sbjct: 4390 EQSSLVPGHLD---QVNGQVVPEA 4410



 Score = 38.1 bits (87), Expect = 0.032
 Identities = 70/279 (25%), Positives = 90/279 (32%), Gaps = 24/279 (8%)

Query: 497 PQKPPPHTEPDSPSP----VLQGEESSERESLPESLELSSPRSPETDWGRPPGGDKDLAS 552
           P  PPP   P SP P    +    E      LPE+L LS P   E+    PP        
Sbjct: 448 PLSPPPEESPTSPPPEASRLSPPPEELPASPLPEALHLSRPLE-ESPLSPPPEESPLSPP 506

Query: 553 PHLGLGSPRVSRASSPEGRHLPSPQLGT---KAPVARPRMSAQEQLERMRRNQECGRPFP 609
           P     SP      SP     PSP L T     P A P     E+       +E     P
Sbjct: 507 PESSPFSPLEESPLSPPEESPPSPALETPLSPPPEASPLSPPFEESPLSPPPEE----LP 562

Query: 610 RPTSPRLLTLGRTLSPARRQPDVEQRPVVGHSGAQKWLR--SSGSWSSPRNTTPYLPTSE 667
               P    L      +   P  E+ P+     A +          S P   +P  P  E
Sbjct: 563 TSPPPEASRLSPPPEESPMSPPPEESPMSPPPEASRLFPPFEESPLSPPPEESPLSPPPE 622

Query: 668 GHRERVLSLSQALATEASQWHRMMTGGNLDSQGDPLPGVP--LPPSDPTRQETPPPRSPP 725
             R         ++    +    M+     S+  PLP V    PP + +    PP  SP 
Sbjct: 623 ASRLSPPPEDSPMSPPPEE--SPMSPPPEVSRLSPLPVVSRLSPPPEESPLSPPPEESP- 679

Query: 726 VANSGSTGFSRRGSGRGGGPTPWGPAWDAGIAPPVLPQD 764
              S     SR        PT   P  D+  +PP  P+D
Sbjct: 680 --TSPPPEASRLSPPPEDSPTS-PPPEDSPASPP--PED 713



 Score = 37.4 bits (85), Expect = 0.054
 Identities = 109/474 (22%), Positives = 164/474 (34%), Gaps = 91/474 (19%)

Query: 325  AHSGSPTYLQLPPRPPGTRASMVLLPGPPLESTFHQSLETDTLLTKLCGQDRLLRRLQEE 384
            +HSG P   +L  +P G+   +        +    Q  +      +L  Q +L ++  ++
Sbjct: 3882 SHSGQP---KLSAQPMGSLQQLQQQQQLQQQQQLQQQQQQ-----QLQQQQQLQQQQLQQ 3933

Query: 385  IDQKQEEKEQLEAALELTRQQLGQATREAGAPGRAWGRQRLLQDRLVSVRATLCHLTQER 444
              Q+Q+ ++Q +  L+  +QQL Q  ++     +   +Q+  Q  L++   TL    Q++
Sbjct: 3934 QQQQQQLQQQQQQQLQQQQQQLQQQQQQQQQQFQQ--QQQQQQMGLLNQSRTLLSPQQQQ 3991

Query: 445  ERVWDTYSGLE----QELGTLRETLEYLLHLGSPQDRVSAQQQLWMVEDTLAGLGGP--- 497
            ++      G+     Q   +       LL  G  Q+ V         E      GGP   
Sbjct: 3992 QQQVALGPGMPAKPLQHFSSPGALGPTLLLTGKEQNTVDPAVSSEATEGPSTHQGGPLAI 4051

Query: 498  --QKPPPHTEPDSPSPVLQGEE-----SSERESLPESLELSSPRSPETDWGRPPGGDKDL 550
                    TEP    P L G+        + +  P SL+L  P        R PG  +  
Sbjct: 4052 GTTPESMATEPGEVKPSLSGDSQLLLVQPQPQPQPSSLQLQPPL-------RLPGQQQQQ 4104

Query: 551  AS--------PHLGLGSPRVSRASS-PEGRHLPSPQLGTKAPVARPRMSAQEQ--LERMR 599
             S         H  LGS   S ASS P     PS  LG +       +   +Q  LER  
Sbjct: 4105 VSLLHTAGGGSHGQLGSGSSSEASSVPHLLAQPSVSLGDQPGSMTQNLLGPQQPMLERPM 4164

Query: 600  RNQECGRPFPRPTSPRLLTLGRTLSPARRQPDVEQRPVVGHSGAQKWLRSSGSWSSPRNT 659
            +N    +P P+P        G  L   +  P V   P VG   AQ               
Sbjct: 4165 QNNTGPQP-PKP--------GPVLQSGQGLPGVGIMPTVGQLRAQ--------------- 4200

Query: 660  TPYLPTSEGHRERVLSLSQALATEASQWHRMMTGGNLDSQGDPLPGVPLPPSDPTRQETP 719
                       + VL+ +  L   + Q  + +    +  Q        L  S   RQ TP
Sbjct: 4201 ----------LQGVLAKNPQLRHLSPQQQQQLQALLMQRQ--------LQQSQAVRQ-TP 4241

Query: 720  PPRSPPVANSGSTGFSRRGSGRGGGPTP-WGPAWDAGI-----APPVLPQDEGA 767
            P + P    S   G        GG P P  GP  + G       PP LP   GA
Sbjct: 4242 PYQEPGTQTSPLQGLLGCQPQLGGFPGPQTGPLQELGAGPRPQGPPRLPAPPGA 4295



 Score = 36.6 bits (83), Expect = 0.092
 Identities = 73/288 (25%), Positives = 101/288 (35%), Gaps = 33/288 (11%)

Query: 157  DDYGQPRSPARPQPGEGPGGPGGPPEVSRGEEGRISESPEVTRLSRGRGRPRLLTPSPTT 216
            D Y +P  P+RPQ  +       PP     E    + S   T L  G G P  L   P  
Sbjct: 2448 DPYSRP--PSRPQSRDPFAPLHKPPRPQPPEVAFKAGSLAHTSLGAG-GFPAALPAGPAG 2504

Query: 217  DLH----SGLQMRRARSPDLFTPLSRP-PSPLSLPRPRSAPARRPPAPSGDTAPPARPHT 271
            +LH    SG      RSP     +  P P   + P+    P+ +PP P     P   PH 
Sbjct: 2505 ELHAKVPSGQPPNFVRSPGTGAFVGTPSPMRFTFPQAVGEPSLKPPVPQPGLPP---PHG 2561

Query: 272  PLSRIDVRPPLDWGPQRQTLS------RPPTPRRGPPSEAGGGKPPRSPQHWSQEPRTQA 325
              S     P L   PQ    +       P     GP S + G     SP          A
Sbjct: 2562 INSHFGPGPTLG-KPQSTNYTVATGNFHPSGSPLGPSSGSTGESYGLSPLRPPSVLPPPA 2620

Query: 326  HSGSPTYLQLPPRPPGTRASMVLLPGPPLESTFHQSLETDTLLTKLCG-QDRLLRRLQEE 384
              GS  YL        ++ S +  P    E      + +     +L G QD  +  L + 
Sbjct: 2621 PDGSLPYLS----HGASQRSGITSPVEKREDP-GTGMGSSLATAELPGTQDPGMSGLSQT 2675

Query: 385  IDQKQEEKEQLEAAL-------ELTRQQLGQATREAGA--PGRAWGRQ 423
              +KQ ++++L   L          RQ+   A   AGA  P  +WG +
Sbjct: 2676 ELEKQRQRQRLRELLIRQQIQRNTLRQEKETAAAAAGAVGPPGSWGAE 2723



 Score = 35.4 bits (80), Expect = 0.20
 Identities = 79/320 (24%), Positives = 111/320 (34%), Gaps = 47/320 (14%)

Query: 473 SPQDRVSAQQQLWMVEDTLAGLGGPQKPPPHTEPDSPSPVLQGEESSERESLPESLELSS 532
           SP   VS    L +V    + L  P +  P + P   SP     E+S     PE    S 
Sbjct: 645 SPPPEVSRLSPLPVV----SRLSPPPEESPLSPPPEESPTSPPPEASRLSPPPEDSPTSP 700

Query: 533 PRSPETDWGRPPGGDKDLA-----SPHLGL-GSPRVSRASSPEGRHL-PSPQLGTKAPVA 585
           P  PE     PP  D  ++     SP L L   P++   S  EG HL P P+        
Sbjct: 701 P--PEDSPASPPPEDSLMSLPLEESPLLPLPEEPQLCPRS--EGPHLSPRPE-------- 748

Query: 586 RPRMSAQEQLERMRRNQECGRPFPRPTSPRLLTLGRT--LSPARRQPDVEQRPVVGHSGA 643
            P +S + +   +    E     P+P  P L  +     LSP    P +  +P   H   
Sbjct: 749 EPHLSPRPEEPHLSPQAEEPHLSPQPEEPCLCAVPEEPHLSPQAEGPHLSPQPEELHLSP 808

Query: 644 QKWLRSSGSWSSPRNTTPYL-PTSEGHRERVLSLSQALATEASQWHRMMTGGNLDSQGDP 702
           Q    +     SP    P L P  E       S    L+    + H      + + +  P
Sbjct: 809 Q----TEEPHLSPVPEEPCLSPQPEESHLSPQSEEPCLSPRPEESHL-----SPELEKPP 859

Query: 703 L-PGVPLPPSDPTRQETP---PPRSPPVANSGSTGFSRRGSGRGGGP--------TPWGP 750
           L P    PP +P +   P   P   PP   S S           G P         P  P
Sbjct: 860 LSPRPEKPPEEPGQCPAPEELPLFPPPGEPSLSPLLGEPALSEPGEPPLSPLPEELPLSP 919

Query: 751 AWDAGIAPPVLPQDEGAWPL 770
           + +  ++P ++P D    PL
Sbjct: 920 SGEPSLSPQLMPPDPLPPPL 939



 Score = 32.3 bits (72), Expect = 1.7
 Identities = 40/162 (24%), Positives = 55/162 (33%), Gaps = 24/162 (14%)

Query: 160  GQPRSPARPQPGEGPGGPGGPPEVSRGEEGRISESPEVTRLSRGRGRPRLLTPSPTTDLH 219
            G+P  P  P P E P  P G P +S          P ++ +      P L   SP  +L 
Sbjct: 904  GEP--PLSPLPEELPLSPSGEPSLSPQLMPPDPLPPPLSPIITAAAPPAL---SPLGELE 958

Query: 220  SGLQMRRARSPD-------LFTPLSRPPSPLSLPRPRSAPARRPPAPSGDTAPPARPHTP 272
                 +    P+       L TP+S PP           P   PP+P      P  P +P
Sbjct: 959  YPFGAKGDSDPESPLAAPILETPISPPPEANCTDPEPVPPMILPPSPGS----PVGPASP 1014

Query: 273  LSRIDVRPPLDWGPQRQTLSRPPTPRRGPPSEAGGGKPPRSP 314
            +    + P          L     P+  PPS+     PP  P
Sbjct: 1015 ILMEPLPPQCS-----PLLQHSLVPQNSPPSQC---SPPALP 1048



 Score = 30.4 bits (67), Expect = 6.6
 Identities = 38/128 (29%), Positives = 45/128 (35%), Gaps = 16/128 (12%)

Query: 227  ARSPDLFTPLSRPPSPLSLPRPRSAPARRPPAPSG-DTAPPARPHTPLSRIDVRPPLDWG 285
            A  P   +PL  P   LS P P  APA    +  G DTAP      P S    +P     
Sbjct: 1085 ALEPSATSPLPSPMGDLSCPAPSPAPALDDFSGLGEDTAPLDGIDAPGS----QPEPGQT 1140

Query: 286  PQRQTLSRPPTPRRGPPSEAGGGKPPRSPQHWSQEPRTQAHSGSPTYLQLPPRPPGTRAS 345
            P         +P    P E      P +P     E +  A  GSP   Q  PR P     
Sbjct: 1141 PGSLASELKGSPVLLDPEELA----PVTPMEVYPECKQTAGQGSPCEEQEEPRAP----- 1191

Query: 346  MVLLPGPP 353
              + P PP
Sbjct: 1192 --VAPTPP 1197



 Score = 30.4 bits (67), Expect = 6.6
 Identities = 36/119 (30%), Positives = 46/119 (38%), Gaps = 26/119 (21%)

Query: 239  PPSPLSLPRPRSAPARRPPAPSGDTAPPARPHTPLSRIDVRPPLDWGPQRQTLSRPPTPR 298
            P  PL  PR  +AP   PP PS   AP             +PP+        L     P 
Sbjct: 2181 PAYPLE-PRFPTAPPTYPPYPSPTGAP------------AQPPM--------LGASSRPG 2219

Query: 299  RGPPSEAGGGKPPRSPQHW--SQEPRTQAHSGSPTYLQLPPRP--PGTRASMVLLPGPP 353
             G P E     PP +P+H   + +P  +    S   L +P  P   G +AS  LL  PP
Sbjct: 2220 AGQPGEF-HTTPPGTPRHQPSTPDPFLKPRCPSLDNLAVPESPGVGGGKASEPLLSPPP 2277



 Score = 30.4 bits (67), Expect = 6.6
 Identities = 48/206 (23%), Positives = 65/206 (31%), Gaps = 33/206 (16%)

Query: 160  GQPRSPARPQPGEGPGGPGGPPEVSRGEEGRISES----------PEVTRLSRGRGRPRL 209
            G    P   QPGE    P G P           +           PE   +  G+    L
Sbjct: 2213 GASSRPGAGQPGEFHTTPPGTPRHQPSTPDPFLKPRCPSLDNLAVPESPGVGGGKASEPL 2272

Query: 210  LTPSPTTDLHSGLQMRR----ARSPDLFTP-LSRPPSPLSLPRPRSAPARRPPAPSGDTA 264
            L+P P  +    L++++    A SP    P L    SP S         + P        
Sbjct: 2273 LSPPPFGESRKALEVKKEELGASSPSYGPPNLGFVDSPSSGTHLGGLELKTPDVFKAPLT 2332

Query: 265  PPARPHTPLSRIDVRPPLDWGPQRQTLSRPPTPRRGPPSEAGGGKPPRSPQHWSQEPRTQ 324
            P A    P S     P L   PQ             PP++A    PP  P  +     T 
Sbjct: 2333 PRASQVEPQS-----PGLGLRPQEP-----------PPAQALAPSPPSHPDIFRPGSYTD 2376

Query: 325  AHSGSPTYLQLPPRPPGTRASMVLLP 350
             ++  P  L   P+PP   +   L P
Sbjct: 2377 PYAQPP--LTPRPQPPPPESCCALPP 2400



 Score = 30.4 bits (67), Expect = 6.6
 Identities = 50/213 (23%), Positives = 73/213 (34%), Gaps = 26/213 (12%)

Query: 453  GLEQELGTLRETLEYLLHLGSPQDRVSAQQQ----LWMVEDTLAGLGGPQKPPPHTEPDS 508
            G+   +G LR  L+ +L        +S QQQ      +++  L      ++ PP+ EP +
Sbjct: 4189 GIMPTVGQLRAQLQGVLAKNPQLRHLSPQQQQQLQALLMQRQLQQSQAVRQTPPYQEPGT 4248

Query: 509  PSPVLQGEESSERESLPESLELSSPRS---PETDWGRPPGGDKDLASPHLGLGSPRVSRA 565
             +  LQG    +    P+      P++    E   G  P G   L +P   L +  V   
Sbjct: 4249 QTSPLQGLLGCQ----PQLGGFPGPQTGPLQELGAGPRPQGPPRLPAPPGALSTGPVLGP 4304

Query: 566  SSPEGRHLPSPQLGTKAPVARPRMSAQEQLERMRRNQECGRPFPRPTSPRLLTLGRTLSP 625
              P     PS     K P   P  S+Q   E        G P P+         G TL P
Sbjct: 4305 VHPTPP--PSSPQEPKRPSQLPSPSSQLPTEAQLPPTHPGTPKPQ---------GPTLEP 4353

Query: 626  ARRQPDVEQRPVVGHSGAQKWLRSSGSWSSPRN 658
                P     P         + +  G W  P N
Sbjct: 4354 ----PPGRVSPAAAQLADTLFSKGLGPWDPPDN 4382


>gi|42542379 serine/arginine repetitive matrix 1 [Homo sapiens]
          Length = 904

 Score = 60.5 bits (145), Expect = 6e-09
 Identities = 142/601 (23%), Positives = 205/601 (34%), Gaps = 69/601 (11%)

Query: 167 RPQPGEGPGGPGGPPEVSRGEEGRISESPEVTRLSRGRGRPRLLTPSPTTDLHSGLQMRR 226
           +P+P   P  P  P + S+ E+ +    P     S+ R R R  +PS T         RR
Sbjct: 249 KPEPIPEPKEPS-PEKNSKKEKEKEKTRPRSRSRSKSRSRTRSRSPSHTR------PRRR 301

Query: 227 ARSPDLFTPLSRPPSPLSLPRPRSAPARRPPAPSGDTAPPARPHTPLSRIDVRPPLDWGP 286
            RS       SR  SP   P PR  P+ R   P     PP R     S +  R       
Sbjct: 302 HRS------RSRSYSPRRRPSPRRRPSPRRRTPPRRMPPPPRHRRSRSPVRRRRRSSASL 355

Query: 287 QRQTLSRPPTPRRGPPSEAGGGKPPRSPQHWSQEPRTQAHSGSPTYLQLPPRPPGTRASM 346
              + S   +  R PP      KPP+      ++ R  + S SP   +  P PP T    
Sbjct: 356 SGSSSSSSSSRSRSPPK-----KPPKRTSSPPRKTRRLSPSASPPRRRHRPSPPATPPPK 410

Query: 347 VLLPGPPLESTFHQSL-------ETDTLLTKLCGQDR------LLRRLQEEIDQKQEEKE 393
                 P +S   +          T   +TK  G ++        +  + E+ + +E+K 
Sbjct: 411 TRHSPTPQQSNRTRKSRVSVSPGRTSGKVTKHKGTEKRESPSPAPKPRKVELSESEEDKG 470

Query: 394 QLEAALELTRQQLGQATREAGAPGRAWGRQRLLQDRLVSVRATLCHLTQERERVWDTYSG 453
              AA + + QQ  Q  R+        G     +D               R R   + S 
Sbjct: 471 GKMAAAD-SVQQRRQYRRQNQQSSSDSGSSSSSEDERPKRSHVKNGEVGRRRRHSPSRSA 529

Query: 454 LEQELGTLRETLEYLLHLGSPQDRVSAQQQLWMVEDTLAGLGGPQKPPPHTEPDSPSPVL 513
                   +ET        SP    + +++             P  PP    P SP P  
Sbjct: 530 SPSPRKRQKETSPRGRRRRSPSPPPTRRRRSPSPAPPPRRRRTPTPPPRRRTP-SPPP-R 587

Query: 514 QGEESSERESLPESLELSSPRSPETDWGRPPGGDKDLASPHLGLGSP----RVSRASSPE 569
           +   S  R S P     S    P+     PP   K  ASP     SP    RVS +  P+
Sbjct: 588 RRSPSPRRYSPPIQRRYSPSPPPKRRTASPPPPPKRRASP-----SPPPKRRVSHSPPPK 642

Query: 570 GRHLP-----SPQLGTK-APVARPRMSAQEQLERMRRNQECGRPFPR----PTSPRLLTL 619
            R  P     SP L +K    + P  S +E        +    P PR     +SP  +  
Sbjct: 643 QRSSPVTKRRSPSLSSKHRKGSSPSRSTREARSPQPNKRHSPSPRPRAPQTSSSPPPVRR 702

Query: 620 GRTLSPARRQ-PDVEQRPV--VGHSGAQKWLRSSGSWSSPRNTTPYLPTSEGHRERVLSL 676
           G + SP RRQ P    RP+  V  +   K ++ + S           P+ +  R    S 
Sbjct: 703 GASSSPQRRQSPSPSTRPIRRVSRTPEPKKIKKAAS-----------PSPQSVRRVSSSR 751

Query: 677 SQALATEASQWHRMMTGGNLDSQGDPLPGVPLPPSDPTRQETPPPRSPPVANSGSTGFSR 736
           S + + E +          + SQ       P  P    +  TP P SPP  NS   G  +
Sbjct: 752 SVSGSPEPAAKKPPAPPSPVQSQSPSTNWSPAVPVKKAKSPTPSP-SPP-RNSDQEGGGK 809

Query: 737 R 737
           +
Sbjct: 810 K 810



 Score = 55.5 bits (132), Expect = 2e-07
 Identities = 100/379 (26%), Positives = 137/379 (36%), Gaps = 68/379 (17%)

Query: 5   RPRSSLSLASSASTISSLSSLSP-KKP----------TRAVNKIHAFGKRGNALRRDPNL 53
           R RSS SL+ S+S+ SS  S SP KKP          TR ++   +  +R +        
Sbjct: 348 RRRSSASLSGSSSSSSSSRSRSPPKKPPKRTSSPPRKTRRLSPSASPPRRRHRPSPPATP 407

Query: 54  PVHIRGWLHKQDSSGLRLWKRRWFVLSGHCLFYYKDSREESVLGSVLLPSYNIRPDGPG- 112
           P   R     Q S+  R  K R  V  G               G V       + + P  
Sbjct: 408 PPKTRHSPTPQQSNRTR--KSRVSVSPGR------------TSGKVTKHKGTEKRESPSP 453

Query: 113 APRGRRFTFTAEHPGMRTYVLAADTLEDLRGWLRALGRASRAEG-----DDYGQPRSPAR 167
           AP+ R+   +         + AAD+++  R + R   ++S   G     +D    RS  +
Sbjct: 454 APKPRKVELSESEEDKGGKMAAADSVQQRRQYRRQNQQSSSDSGSSSSSEDERPKRSHVK 513

Query: 168 -----------PQPGEGPGGPGGPPEVSRGEEGRISESPEVTRLSRGRG------RPRLL 210
                      P     P       E S     R S SP  TR  R         R R  
Sbjct: 514 NGEVGRRRRHSPSRSASPSPRKRQKETSPRGRRRRSPSPPPTRRRRSPSPAPPPRRRRTP 573

Query: 211 TPSPTTDLHSGLQMRRARSPDLFTP-LSRPPSPLSLPRPRSAPARRPPAPSGDTAPPARP 269
           TP P     S    RR+ SP  ++P + R  SP   P+ R+A    PP      +PP   
Sbjct: 574 TPPPRRRTPSPPPRRRSPSPRRYSPPIQRRYSPSPPPKRRTASPPPPPKRRASPSPP--- 630

Query: 270 HTPLSRIDVRPPLDWGPQRQTLSRPPTPRRGP---PSEAGGGKPPRSPQHWSQEPRTQAH 326
             P  R+   PP    P+++  S P T RR P        G  P RS +        + H
Sbjct: 631 --PKRRVSHSPP----PKQR--SSPVTKRRSPSLSSKHRKGSSPSRSTREARSPQPNKRH 682

Query: 327 SGSPTYLQLPPRPPGTRAS 345
           S SP      PR P T +S
Sbjct: 683 SPSPR-----PRAPQTSSS 696



 Score = 42.0 bits (97), Expect = 0.002
 Identities = 93/433 (21%), Positives = 150/433 (34%), Gaps = 72/433 (16%)

Query: 362 LETDTLLTKLCGQDRLLRRLQEEIDQKQEEKEQLEAALELTRQQLGQATREAGAPGRAWG 421
           L+ + +  +   Q++L    +++ D+ + +KE+ E++ E   +      R++ +P     
Sbjct: 126 LKKEEIKQRQIEQEKLASMKKQDEDKDKRDKEEKESSREKRERSRSPRRRKSRSPSPRRR 185

Query: 422 RQRLLQDRLVSVRATLCHLTQERERVWDTYSGLEQELGTLRETLEYLLHLGSPQDRVS-- 479
              + ++R  S   +  H T+ R                  E  E    L  P  +V   
Sbjct: 186 SSPVRRERKRSHSRSPRHRTKSRSP------------SPAPEKKEKTPELPEPSVKVKEP 233

Query: 480 AQQQLWMVEDTLAGLGGPQKPPPHTEPDSPSPVLQGEESSERE-----SLPESLELSSPR 534
           + Q+     D L       KP P  EP  PSP    ++  E+E     S   S   S  R
Sbjct: 234 SVQEATSTSDILK----VPKPEPIPEPKEPSPEKNSKKEKEKEKTRPRSRSRSKSRSRTR 289

Query: 535 SPETDWGRPPGGDKDLASPHLGLGSPRVSRASSPE----GRHLPSP--QLGTKAPVARPR 588
           S      RP    +  +  +     P   R  SP      R +P P     +++PV R R
Sbjct: 290 SRSPSHTRPRRRHRSRSRSYSPRRRPSPRRRPSPRRRTPPRRMPPPPRHRRSRSPVRRRR 349

Query: 589 MS------AQEQLERMRRNQECGRPFPRPTSPRLLT--LGRTLSPARRQ----PDVEQRP 636
            S      +       R      +P  R +SP   T  L  + SP RR+    P     P
Sbjct: 350 RSSASLSGSSSSSSSSRSRSPPKKPPKRTSSPPRKTRRLSPSASPPRRRHRPSPPATPPP 409

Query: 637 VVGHSGAQKWL-------------RSSGSWSSPRNTTPYLPTSEGHRERVLSLSQA---- 679
              HS   +               R+SG  +  + T      S   + R + LS++    
Sbjct: 410 KTRHSPTPQQSNRTRKSRVSVSPGRTSGKVTKHKGTEKRESPSPAPKPRKVELSESEEDK 469

Query: 680 ----LATEASQWHRMMTGGNLDSQGDPLPGVPLPPSDPTRQETPPPRSPPVANSGSTGFS 735
                A ++ Q  R     N  S  D         S  + ++  P RS     +G  G  
Sbjct: 470 GGKMAAADSVQQRRQYRRQNQQSSSD-------SGSSSSSEDERPKRSH--VKNGEVGRR 520

Query: 736 RRGS-GRGGGPTP 747
           RR S  R   P+P
Sbjct: 521 RRHSPSRSASPSP 533



 Score = 42.0 bits (97), Expect = 0.002
 Identities = 50/185 (27%), Positives = 71/185 (38%), Gaps = 36/185 (19%)

Query: 163 RSPARPQPGEGPGGPGGPPEVSRGEEGRISESPEVTRLSRGRGRPRLLTPSPTTDLHSGL 222
           R+ + P P +    P  PP+       R+S SP      + R  P     SP+       
Sbjct: 613 RTASPPPPPKRRASPSPPPK------RRVSHSPP----PKQRSSPVTKRRSPSLSS---- 658

Query: 223 QMRRARSPDLFTPLSRPPSPLSLPRPRSAPARRPPAPSGDTAPPARPHTPLSRIDVRPPL 282
           + R+  SP   T  +R P P      R +P+ RP AP   ++PP           VR   
Sbjct: 659 KHRKGSSPSRSTREARSPQP----NKRHSPSPRPRAPQTSSSPP----------PVRRGA 704

Query: 283 DWGPQRQTLSRPPT------PRRGPPSEAGGGKPPRSPQHWSQEPRTQAHSGSP-TYLQL 335
              PQR+    P T       R   P +      P SPQ   +   +++ SGSP    + 
Sbjct: 705 SSSPQRRQSPSPSTRPIRRVSRTPEPKKIKKAASP-SPQSVRRVSSSRSVSGSPEPAAKK 763

Query: 336 PPRPP 340
           PP PP
Sbjct: 764 PPAPP 768



 Score = 35.0 bits (79), Expect = 0.27
 Identities = 44/162 (27%), Positives = 58/162 (35%), Gaps = 42/162 (25%)

Query: 162 PRSPARPQPGEGPGGP---GGPPEVSRGEEG----RISESPE---VTRLSRGRGRPRLLT 211
           P+   R  P   P  P     PP V RG       R S SP    + R+SR        T
Sbjct: 676 PQPNKRHSPSPRPRAPQTSSSPPPVRRGASSSPQRRQSPSPSTRPIRRVSR--------T 727

Query: 212 PSPTTDLHSGLQMRRARSPDLFTPLSRPPSPLSLPRPRSAPARRPPAPSGDTAPPARPHT 271
           P P        ++++A SP        P S   +   RS      PA     APP+   +
Sbjct: 728 PEPK-------KIKKAASPS-------PQSVRRVSSSRSVSGSPEPAAKKPPAPPSPVQS 773

Query: 272 PLSRIDVRPPLDWGPQRQT-LSRPPTPRRGPP---SEAGGGK 309
                   P  +W P      ++ PTP   PP    + GGGK
Sbjct: 774 Q------SPSTNWSPAVPVKKAKSPTPSPSPPRNSDQEGGGK 809



 Score = 33.5 bits (75), Expect = 0.78
 Identities = 44/178 (24%), Positives = 60/178 (33%), Gaps = 16/178 (8%)

Query: 152 SRAEGDDYGQPRSPARPQPGEGPGGPGGPPEVSRGEEGRISESPEVTRLSRGRGRPRLLT 211
           SR++     + RSP+  +P             SR    R   SP      R R  PR + 
Sbjct: 280 SRSKSRSRTRSRSPSHTRPRRRHRSR------SRSYSPRRRPSPRRRPSPRRRTPPRRMP 333

Query: 212 PSPTTDLHSGLQMRRARSPDLFTPLSRPPS-------PLSLPRPRSAPARRPPAPSGDTA 264
           P P          RR RS    +  S   S       P   P+  S+P R+    S   +
Sbjct: 334 PPPRHRRSRSPVRRRRRSSASLSGSSSSSSSSRSRSPPKKPPKRTSSPPRKTRRLSPSAS 393

Query: 265 PPARPHTPLSRIDVRPPLDWGPQRQTLSRPPTPRRGPPSEAGGGKPPRSPQHWSQEPR 322
           PP R H P       P     P  Q  +R    R+   S + G    +  +H   E R
Sbjct: 394 PPRRRHRPSPPATPPPKTRHSPTPQQSNR---TRKSRVSVSPGRTSGKVTKHKGTEKR 448


>gi|18959210 WIRE protein [Homo sapiens]
          Length = 440

 Score = 59.7 bits (143), Expect = 1e-08
 Identities = 68/263 (25%), Positives = 100/263 (38%), Gaps = 44/263 (16%)

Query: 136 DTLEDLRGWLRALGRASRAEGDDYGQPRSPARPQPGEGPGGPGGPPEVSRGEEGRISESP 195
           D  +  R  L  L R  R    D  +P + +          P  PP    G       +P
Sbjct: 136 DDTDSSRASLPELPRMQRPSLPDLSRPNTTSSTGMKHSSSAPPPPPP---GRRANAPPTP 192

Query: 196 EVTRLSRGRG--RPRLLTPSPTTDLHSGLQMRRARSPDLFTPLSRPPSPLSLPR------ 247
                S+     R + L P+P   LH G +      P    P+  PPSP+++        
Sbjct: 193 LPMHSSKAPAYNREKPLPPTPGQRLHPGRE-----GPPAPPPVKPPPSPVNIRTGPSGQS 247

Query: 248 --PRSAPARRPP-------APSGDTAP--PARPHT-------PLSRIDVRPPLDWGPQRQ 289
             P   P R+PP       +P+ ++AP  P R ++       P+  +   PP    P   
Sbjct: 248 LAPPPPPYRQPPGVPNGPSSPTNESAPELPQRHNSLHRKTPGPVRGLAPPPPTSASPSLL 307

Query: 290 TLSRPPTPRRGPPSEAGGGKPPRSP--QHWSQE-----PRTQAHSGSPTYLQLPPRPPG- 341
           + +RPP P R PPS  G   PP  P  ++ +++     P  + H   P     PP PP  
Sbjct: 308 S-NRPPPPARDPPSR-GAAPPPPPPVIRNGARDAPPPPPPYRMHGSEPPSRGKPPPPPSR 365

Query: 342 TRASMVLLPGPPLESTFHQSLET 364
           T A     P PPL +    S+ T
Sbjct: 366 TPAGPPPPPPPPLRNGHRDSITT 388



 Score = 53.5 bits (127), Expect = 7e-07
 Identities = 61/212 (28%), Positives = 80/212 (37%), Gaps = 31/212 (14%)

Query: 165 PARPQPGEGPGGPGGPPEVSRGEEGRISES-----PEVTRLSRGRGRPRLLTPSPTTDLH 219
           PA   P      P  P   + G     ++S     PE+ R+ R    P L  P+ T+   
Sbjct: 111 PALQIPSSRAAAPRPPVSAASGRPQDDTDSSRASLPELPRMQRP-SLPDLSRPNTTSSTG 169

Query: 220 SGLQMRRARSPDLFTPLSRPPSPLSLPRPRSAPARR----PPAPS-----GDTAPPARPH 270
                     P      + PP+PL +   ++    R    PP P      G   PPA P 
Sbjct: 170 MKHSSSAPPPPPPGRRANAPPTPLPMHSSKAPAYNREKPLPPTPGQRLHPGREGPPAPPP 229

Query: 271 T--PLSRIDVRPPLDWGPQRQTLSRPPTPRRGPPSEAGGGKPPRSPQHWSQEPRTQAHSG 328
              P S +++R     GP  Q+L+ PP P R PP    G   P SP + S     Q H+ 
Sbjct: 230 VKPPPSPVNIRT----GPSGQSLAPPPPPYRQPPGVPNG---PSSPTNESAPELPQRHNS 282

Query: 329 SPTYLQLPPR----PPGTRASMVLL---PGPP 353
                  P R    PP T AS  LL   P PP
Sbjct: 283 LHRKTPGPVRGLAPPPPTSASPSLLSNRPPPP 314



 Score = 46.6 bits (109), Expect = 9e-05
 Identities = 65/228 (28%), Positives = 86/228 (37%), Gaps = 34/228 (14%)

Query: 159 YGQPRSPARPQPGEGPGG-----PGGPPEVSRGEEGRISESPEVTR-------LSRGRGR 206
           YG   +  +P+ G   GG     P G  + S    G+ +     +R       +S   GR
Sbjct: 74  YGSGGAALQPKGGLFQGGVLKLRPVGAKDGSENLAGKPALQIPSSRAAAPRPPVSAASGR 133

Query: 207 PRLLTPSPTTDLHSGLQMRRARSPDLFTPLSRPPSPLSLPRPRSAPARRPPAPSGDT-AP 265
           P+  T S    L    +M+R   PDL    SRP +  S     S+ A  PP P     AP
Sbjct: 134 PQDDTDSSRASLPELPRMQRPSLPDL----SRPNTTSSTGMKHSSSAPPPPPPGRRANAP 189

Query: 266 PARPHTPLSRIDVRPPLDWGPQRQTLSRPPTP-------RRGPPSEAGGGKPPRSPQHWS 318
           P    TPL     + P       +    PPTP       R GPP+     KPP SP +  
Sbjct: 190 P----TPLPMHSSKAPA----YNREKPLPPTPGQRLHPGREGPPAPPPV-KPPPSPVNIR 240

Query: 319 QEPRTQAHSGSPTYLQLPPRPPGTRASMVLLPGPPLESTFHQSLETDT 366
             P  Q+ +  P   + PP  P   +S      P L    H SL   T
Sbjct: 241 TGPSGQSLAPPPPPYRQPPGVPNGPSSPTNESAPELPQR-HNSLHRKT 287



 Score = 35.8 bits (81), Expect = 0.16
 Identities = 73/299 (24%), Positives = 95/299 (31%), Gaps = 62/299 (20%)

Query: 495 GGPQKPPPHTEPDSPSPVL-------QGEESSERESLPESLELSSPRSPETDWGRPPGGD 547
           G P    P +   +P P +       Q +  S R SLPE   +  P  P+      P   
Sbjct: 109 GKPALQIPSSRAAAPRPPVSAASGRPQDDTDSSRASLPELPRMQRPSLPDLS---RPNTT 165

Query: 548 KDLASPHLGLGSPRVSRASSPEGRHLPSPQLGTKAPVA-RPRMSAQEQLERMRRNQECGR 606
                 H     P             P P   +KAP   R +       +R+   +E G 
Sbjct: 166 SSTGMKHSSSAPPPPPPGRRANAPPTPLPMHSSKAPAYNREKPLPPTPGQRLHPGRE-GP 224

Query: 607 PFPRPTSP-------RLLTLGRTLSPARRQPDVEQRPVVGHSGAQKWLRSSGSWSSPRN- 658
           P P P  P       R    G++L+P    P   Q P V +             SSP N 
Sbjct: 225 PAPPPVKPPPSPVNIRTGPSGQSLAPP--PPPYRQPPGVPNGP-----------SSPTNE 271

Query: 659 TTPYLPTSEGHRER-----VLSLSQALATEASQWHRMMTGGNLDSQGDPLPGVPLPPS-D 712
           + P LP       R     V  L+    T AS                 L   P PP+ D
Sbjct: 272 SAPELPQRHNSLHRKTPGPVRGLAPPPPTSASP--------------SLLSNRPPPPARD 317

Query: 713 PTRQETPPPRSPPVANSGSTG-------FSRRGS--GRGGGPTPWGPAWDAGIAPPVLP 762
           P  +   PP  PPV  +G+         +   GS     G P P      AG  PP  P
Sbjct: 318 PPSRGAAPPPPPPVIRNGARDAPPPPPPYRMHGSEPPSRGKPPPPPSRTPAGPPPPPPP 376



 Score = 33.1 bits (74), Expect = 1.0
 Identities = 55/236 (23%), Positives = 72/236 (30%), Gaps = 75/236 (31%)

Query: 493 GLGGPQKPPPHTEPDSPSPVLQGEESSERESLPESLELSSPRSPETDWGRPPGGDKDLAS 552
           G  GP  PPP   P SP  +  G         P    L+ P  P   + +PPG     +S
Sbjct: 220 GREGPPAPPPVKPPPSPVNIRTG---------PSGQSLAPPPPP---YRQPPGVPNGPSS 267

Query: 553 PHLGLGSPRVSRASSPEGRHLPSPQLGTKAPVARPRMSAQEQLERMRRNQECGRPFPRPT 612
           P     +P + +  +   R  P P  G   P   P  SA   L          RP P   
Sbjct: 268 P-TNESAPELPQRHNSLHRKTPGPVRGLAPP---PPTSASPSL-------LSNRPPPPAR 316

Query: 613 SPRLLTLGRTLSPARRQPDVEQRPVVGHSGAQKWLRSSGSWSSPRNTTPYLPTSEGHRER 672
            P          P+R        PV+           +G+  +P    PY          
Sbjct: 317 DP----------PSRGAAPPPPPPVI----------RNGARDAPPPPPPY---------- 346

Query: 673 VLSLSQALATEASQWHRMMTGGNLDSQGDPLPGVPLPPSDPTRQETPPPRSPPVAN 728
                             M G    S+G P P     P+ P     PPP  PP+ N
Sbjct: 347 -----------------RMHGSEPPSRGKPPPPPSRTPAGP-----PPPPPPPLRN 380


>gi|34013590 Rho GTPase activating protein 2 [Homo sapiens]
          Length = 698

 Score = 58.9 bits (141), Expect = 2e-08
 Identities = 52/155 (33%), Positives = 70/155 (45%), Gaps = 19/155 (12%)

Query: 25  LSPK--KPTRAVNKIHAFGKRGNALRRDPNL----PVHIRGWLHKQDSSGLRLWKRRWFV 78
           LSPK  +  RA +K    G++  +  R P      PV   GWL KQ S  ++ W++RWFV
Sbjct: 2   LSPKIRQARRARSKSLVMGEQSRSPGRMPCPHRLGPVLKAGWLKKQRSI-MKNWQQRWFV 60

Query: 79  LSGHCLFYYKDSREESVLGSVLLPSYNIR--PDGPGAPRGRRFTFTAEHPGMRTYV---- 132
           L G  LFYYKD  E    G + L    +   P GP  P    F  +    G R  V    
Sbjct: 61  LRGDQLFYYKDKDEIKPQGFISLQGTQVTELPPGPEDPGKHLFEISPGGAGEREKVPANP 120

Query: 133 ----LAADTLEDLRGWLRALGRASRAE--GDDYGQ 161
               L A +  D+  W++A+ R   A   G  +GQ
Sbjct: 121 EALLLMASSQRDMEDWVQAIRRVIWAPLGGGIFGQ 155


>gi|41349482 proline-rich protein BstNI subfamily 1 isoform 1
           preproprotein [Homo sapiens]
          Length = 331

 Score = 57.8 bits (138), Expect = 4e-08
 Identities = 60/199 (30%), Positives = 84/199 (42%), Gaps = 29/199 (14%)

Query: 149 GRASRAEGDDYGQPRSPARPQPGEGPGGPGGPPEVSRGEEGRISESPEVTRLSRGRGRPR 208
           G  SR+     G+P+ P  PQ G  P GP  PP   +G   +  + P+        G+P+
Sbjct: 145 GDKSRSPRSPPGKPQGPP-PQGGNQPQGPPPPPGKPQGPPPQGGKKPQGPPPP---GKPQ 200

Query: 209 LLTPSPTTDLHSGLQMRRARSPDLFTPLSRPPSPLSLPRPRSAPARRP--PAPSGDTAP- 265
              P P  D     + R ++SP    P   PP   + P+    P  +P  P P G   P 
Sbjct: 201 --GPPPQGD-----KSRSSQSPP-GKPQGPPPQGGNQPQGPPPPPGKPQGPPPQGGNKPQ 252

Query: 266 -PARPHTPLSRIDVRPPLDWGPQRQTLSRPPTPRRGPPSEAGG---GKPPRSPQHWSQEP 321
            P  P  P       PP   G + Q+   PP   +GPP + G    G PP +  +  Q+P
Sbjct: 253 GPPPPGKPQG-----PPAQGGSKSQSARSPPGKPQGPPQQEGNNPQGPPPPAGGN-PQQP 306

Query: 322 RTQAHSGSPTYLQLPPRPP 340
           +    +G P   Q PPRPP
Sbjct: 307 QAPP-AGQP---QGPPRPP 321



 Score = 53.9 bits (128), Expect = 6e-07
 Identities = 58/220 (26%), Positives = 84/220 (38%), Gaps = 38/220 (17%)

Query: 155 EGDDYGQPRS-PARPQ--PGEGPGGPGGPPEVSRGEEGRISESPEVTRLSRGRGRPRLLT 211
           +GD    PRS P +PQ  P +G   P GPP      +G   +     +     G+P+   
Sbjct: 83  QGDKSRSPRSPPGKPQGPPPQGGNQPQGPPPPPGKPQGPPPQGGNRPQGPPPPGKPQ--G 140

Query: 212 PSPTTDLHSGLQMRRARSPDLFTPLSRPPSPLSLPRPRSAPARRPPAPSGDTAPP----A 267
           P P  D        ++RSP   +P  +P  P   P+  + P   PP P     PP     
Sbjct: 141 PPPQGD--------KSRSPR--SPPGKPQGP--PPQGGNQPQGPPPPPGKPQGPPPQGGK 188

Query: 268 RPHTPLSRIDVRPPLDWGPQRQTLSRPPTPRRGPPSEAGG---------GKPPRSPQHWS 318
           +P  P      + P   G + ++   PP   +GPP + G          GKP   P    
Sbjct: 189 KPQGPPPPGKPQGPPPQGDKSRSSQSPPGKPQGPPPQGGNQPQGPPPPPGKPQGPPPQGG 248

Query: 319 QEPRTQAHSGSPTYLQLPPRPPGTRASMVLLP-----GPP 353
            +P+     G P   Q PP   G+++     P     GPP
Sbjct: 249 NKPQGPPPPGKP---QGPPAQGGSKSQSARSPPGKPQGPP 285



 Score = 53.5 bits (127), Expect = 7e-07
 Identities = 53/182 (29%), Positives = 70/182 (38%), Gaps = 38/182 (20%)

Query: 160 GQPRSPARPQPGEGPGGPGGPPEVSRGEEGRISESPEVTRLSRGRGRPRLLTPSPTTDLH 219
           G P+ P+ PQ G  P GP  PP   +G   +    P+        G+P+   P P  D  
Sbjct: 34  GNPQGPS-PQGGNKPQGPPPPPGKPQGPPPQGGNKPQGPPPP---GKPQ--GPPPQGD-- 85

Query: 220 SGLQMRRARSPDLFTPLSRPPSPLSLPRPRSAPARRPPAPSGDTAPPARPHTPLSRIDVR 279
                 ++RSP        PP      +P+  P +    P G   PP +P  P       
Sbjct: 86  ------KSRSP------RSPPG-----KPQGPPPQGGNQPQGPPPPPGKPQGP------- 121

Query: 280 PPLDWGPQRQTLSRPPTPRRGPPSEAGGGKPPRSPQHWSQEPRTQAHSGSPTYLQLPPRP 339
           PP   G  R     PP   +GPP +    + PRSP    Q P  Q  +      Q PP P
Sbjct: 122 PP--QGGNRPQGPPPPGKPQGPPPQGDKSRSPRSPPGKPQGPPPQGGNQP----QGPPPP 175

Query: 340 PG 341
           PG
Sbjct: 176 PG 177



 Score = 52.8 bits (125), Expect = 1e-06
 Identities = 44/157 (28%), Positives = 62/157 (39%), Gaps = 12/157 (7%)

Query: 162 PRSPARPQPGEGPGGPGGPPEVSRGEEGRISESPEVTRLS---RGRGRPRLLTPSPTTDL 218
           P+   +PQ    PG P GPP   +G++ R S+SP         +G  +P+   P P    
Sbjct: 184 PQGGKKPQGPPPPGKPQGPPP--QGDKSRSSQSPPGKPQGPPPQGGNQPQ--GPPPPPGK 239

Query: 219 HSGLQMRRARSPDLFTPLSRPPSPLSLPRPRSAPARRPPAPSGDTAPPARPHTPLSRIDV 278
             G   +    P    P  +P  P +    +S  AR PP       P   P    +    
Sbjct: 240 PQGPPPQGGNKPQGPPPPGKPQGPPAQGGSKSQSARSPPGK-----PQGPPQQEGNNPQG 294

Query: 279 RPPLDWGPQRQTLSRPPTPRRGPPSEAGGGKPPRSPQ 315
            PP   G  +Q  + P    +GPP    GG+P R PQ
Sbjct: 295 PPPPAGGNPQQPQAPPAGQPQGPPRPPQGGRPSRPPQ 331



 Score = 48.1 bits (113), Expect = 3e-05
 Identities = 67/275 (24%), Positives = 86/275 (31%), Gaps = 41/275 (14%)

Query: 497 PQKPPPHTEPDSPSPVLQGEESSERESLPESLELSSPRSPETDWGRPPGGDKDLASPHLG 556
           PQ PPP  +P  P P  QG++S    S P   +   P+      G PP   K    P  G
Sbjct: 68  PQGPPPPGKPQGPPP--QGDKSRSPRSPPGKPQGPPPQGGNQPQGPPPPPGKPQGPPPQG 125

Query: 557 LGSPRVSRASSPEGRHLPSPQLGTKAPVARPRMSAQEQLERMRRNQECGRPFPRPTSPRL 616
              P   +   P G+    P  G K+   R      +       NQ  G P P P  P+ 
Sbjct: 126 GNRP---QGPPPPGKPQGPPPQGDKSRSPRSPPGKPQGPPPQGGNQPQGPP-PPPGKPQ- 180

Query: 617 LTLGRTLSPARRQPDVEQRPVVGHSGAQKWLRSSGSWSSPRNTTPYLPTSEGHRERVLSL 676
                   P  +     Q P                   P    P  P  +G + R    
Sbjct: 181 -------GPPPQGGKKPQGP-------------------PPPGKPQGPPPQGDKSR---- 210

Query: 677 SQALATEASQWHRMMTGGNLDSQGDPLPGVPL--PPSDPTRQETPPPRSPPVANSGSTGF 734
             + +           GGN      P PG P   PP    + + PPP   P     + G 
Sbjct: 211 -SSQSPPGKPQGPPPQGGNQPQGPPPPPGKPQGPPPQGGNKPQGPPPPGKP-QGPPAQGG 268

Query: 735 SRRGSGRGGGPTPWGPAWDAGIAPPVLPQDEGAWP 769
           S+  S R     P GP    G  P   P   G  P
Sbjct: 269 SKSQSARSPPGKPQGPPQQEGNNPQGPPPPAGGNP 303



 Score = 44.7 bits (104), Expect = 3e-04
 Identities = 40/144 (27%), Positives = 56/144 (38%), Gaps = 11/144 (7%)

Query: 497 PQKPPPHTEPDSPSPVLQGEESSERESLPESLELSSPRSPETDWGRPPGGDKDLASPHLG 556
           PQ PPP  +P  P P  QG++S   +S P   +   P+      G PP   K    P  G
Sbjct: 190 PQGPPPPGKPQGPPP--QGDKSRSSQSPPGKPQGPPPQGGNQPQGPPPPPGKPQGPPPQG 247

Query: 557 LGSPR-VSRASSPEGRHLPSPQLGTKAPVARPRMSAQEQLERMRRNQECGRPFPRPTSPR 615
              P+       P+G   P  Q G+K+  AR      +   +   N   G P P   +P+
Sbjct: 248 GNKPQGPPPPGKPQG---PPAQGGSKSQSARSPPGKPQGPPQQEGNNPQGPPPPAGGNPQ 304

Query: 616 LLTLGRTLSPARRQPDVEQRPVVG 639
                +  +P   QP    RP  G
Sbjct: 305 -----QPQAPPAGQPQGPPRPPQG 323



 Score = 38.5 bits (88), Expect = 0.024
 Identities = 32/107 (29%), Positives = 43/107 (40%), Gaps = 14/107 (13%)

Query: 236 LSRPPSP-LSLPRPRSAPARRPPAPSGDTAPPARPHTPLSRIDVRPPLDWGPQRQTLSRP 294
           +S+  SP L    P+    +    P G   PP +P  P  +   +P    GP       P
Sbjct: 23  VSQEESPSLIAGNPQGPSPQGGNKPQGPPPPPGKPQGPPPQGGNKPQ---GPP------P 73

Query: 295 PTPRRGPPSEAGGGKPPRSPQHWSQEPRTQAHSGSPTYLQLPPRPPG 341
           P   +GPP +    + PRSP    Q P  Q  +      Q PP PPG
Sbjct: 74  PGKPQGPPPQGDKSRSPRSPPGKPQGPPPQGGNQP----QGPPPPPG 116



 Score = 32.0 bits (71), Expect = 2.3
 Identities = 24/73 (32%), Positives = 28/73 (38%), Gaps = 7/73 (9%)

Query: 693 GGNLDSQGDPLPGVPL--PPSDPTRQETPP----PRSPPVANSGSTGFSRRGSGRGGGPT 746
           GGN      P PG P   PP    + + PP    P+ PP     S    R   G+  GP 
Sbjct: 43  GGNKPQGPPPPPGKPQGPPPQGGNKPQGPPPPGKPQGPPPQGDKSRS-PRSPPGKPQGPP 101

Query: 747 PWGPAWDAGIAPP 759
           P G     G  PP
Sbjct: 102 PQGGNQPQGPPPP 114


>gi|78042577 MAP7 domain containing 1 [Homo sapiens]
          Length = 841

 Score = 57.8 bits (138), Expect = 4e-08
 Identities = 94/413 (22%), Positives = 150/413 (36%), Gaps = 53/413 (12%)

Query: 150 RASRAEGDDYGQPRSPARPQPGEGPGGPGGPPEVSRGEEGRISESPEVTRLSRGRG---R 206
           R  R + +  G P +P R +P   P       +  R  E   S       L + +     
Sbjct: 388 RGERRKPNAGGSP-APVRRRPEASPVQKKEKKDKERENEKEKSALARERSLKKRQSLPAS 446

Query: 207 PRLLTPSPTTDLHSGLQMRRARSPDLFTPLSRPPSPLSLPRPRSAPARRPPAPSGDTAPP 266
           PR    + T    S     R  SP   T   RP SP   P P      +PP+P G TA P
Sbjct: 447 PRARLSASTASELSPKSKARPSSPS--TSWHRPASPCPSPGPGHTLPPKPPSPRGTTASP 504

Query: 267 ARPHTPLSRIDVRPPLDWGPQRQTLSRPPTPRRGPPSEAGGGKPPRSPQHWSQEPRTQAH 326
                             G  R+      +P    P +    K   S +  S  P + A 
Sbjct: 505 K-----------------GRVRRKEEAKESPSAAGPEDKSQSKRRASNEKESAAPASPAP 547

Query: 327 SGSPTYLQLPP---RPPG---TRASMVL---LPGPPLESTFHQSLETD-----TLLTKLC 372
           S +P+    PP   +PP    T A+++     P PP+  +   +  TD      LL +  
Sbjct: 548 SPAPSPTPAPPQKEQPPAETPTDAAVLTSPPAPAPPVTPSKPMAGTTDREEATRLLAEKR 607

Query: 373 GQDRLLRRLQEEIDQKQEEKEQLEAALELTRQQLGQATREAGAPGR------------AW 420
            Q R  R  +E+  + Q E+++     +L R+   +A REA A  R              
Sbjct: 608 RQAREQREREEQERRLQAERDKRMREEQLAREAEARAEREAEARRREEQEAREKAQAEQE 667

Query: 421 GRQRLLQDRLVSVRATLCHLTQERERVWDTYSGLEQELGTLRETLEYLLHLGSPQDRVSA 480
            ++RL + +  +   +     ++R      +   EQE    R+ LE ++     + R S 
Sbjct: 668 EQERLQKQKEEAEARSREEAERQRLEREKHFQQQEQERQERRKRLEEIM----KRTRKSE 723

Query: 481 QQQLWMVEDTLAGLGGPQKPPPHTEPDSPSPVLQGEESSERESLPESLELSSP 533
             +    +D+         P P    ++ SP LQ E   + E +P+  + S P
Sbjct: 724 VSETKQKQDSKEANANGSSPEPVKAVEARSPGLQKEAVQKEEPIPQEPQWSLP 776



 Score = 38.5 bits (88), Expect = 0.024
 Identities = 132/594 (22%), Positives = 196/594 (32%), Gaps = 121/594 (20%)

Query: 239 PPSPLSLPRPRSAPARRPPAPSG-------DTAPPARPHTPLSRIDVRPPLDWGPQRQTL 291
           PP P   P P   P+  PP  S        DT P  +  T   ++ + P     P  Q  
Sbjct: 22  PPEPR--PSPEGDPSPPPPPMSALVPDTPPDTPPAMKNATSSKQLPLEPE---SPSGQVG 76

Query: 292 SRPPTPRRGPPSEAGGGKPPRSPQHWSQEPRTQAHSGSPTYLQLPPRPPGTRASMVLLPG 351
            RP  P+   PS     + P  P    ++ R    S  P+   +P               
Sbjct: 77  PRPAPPQEESPSSEAKSRGPTPPAMGPRDARPPRRSSQPSPTAVPAS-----------DS 125

Query: 352 PPLESTFHQSLETDTLLTKLCGQDRLLRRLQEEIDQKQEEKEQLEA--ALELTRQQLGQA 409
           PP +              K  G+   L +     ++++E  + L A  A+ L +++  +A
Sbjct: 126 PPTKQE-----------VKKAGERHKLAK-----ERREERAKYLAAKKAVWLEKEEKAKA 169

Query: 410 TREAGAPGRAWGRQRLLQDRLVSV--RATLCHLTQERERVWDTYSGLEQELGTLRETLEY 467
            RE     R   R+RL + RL +   RA L    +ER+R         Q+L   +E  E 
Sbjct: 170 LREKQLQER---RRRLEEQRLKAEQRRAAL----EERQR---------QKLEKNKERYEA 213

Query: 468 LLHLGSPQDRVSAQQQLWMVEDTLAGLGGPQKP------------PPHTEP--------- 506
            +     +     +QQ W     L       K             P H +          
Sbjct: 214 AIQRSVKKTWAEIRQQRWSWAGALHHSSPGHKTSGSRCSVSAVNLPKHVDSIINKRLSKS 273

Query: 507 -----DSPSP----VLQGEESS--ERESLPESLELSSPRSPET--DWGRPPGGDKDLA-S 552
                +SPS      L   ESS  +R   P    L+  RS  T    GR  G   D    
Sbjct: 274 SATLWNSPSRNRSLQLSAWESSIVDRLMTPTLSFLARSRSAVTLPRNGRDQGRGCDPGRG 333

Query: 553 PHLGLGSPRVSRASSPEGRHLPSPQLGTKAPVARPRMSAQEQLE--RMRRNQECGRPFPR 610
           P  G     ++R   P+  H PS       PV  PR ++   L    + R+     P   
Sbjct: 334 PTWGRAGASLARGPQPDRTH-PS----AAVPVC-PRSASASPLTPCSVTRSVHRCAPAGE 387

Query: 611 PTSPRLLTLGRTLSPARRQPDV------EQRPVVGHSGAQKWLRSSGSWSSPRNTTPYLP 664
               R    G + +P RR+P+       E++     +  +K   +       R + P  P
Sbjct: 388 RGERRKPNAGGSPAPVRRRPEASPVQKKEKKDKERENEKEKSALARERSLKKRQSLPASP 447

Query: 665 TSEGHRERVLSLSQAL----ATEASQWHRMMTGGNLDSQGDPLPGVPLPPSDPT------ 714
            +         LS       ++ ++ WHR  +       G  LP  P  P   T      
Sbjct: 448 RARLSASTASELSPKSKARPSSPSTSWHRPASPCPSPGPGHTLPPKPPSPRGTTASPKGR 507

Query: 715 -RQETPPPRSPPVANSGSTGFS-RRGSGRGGGPTPWGPAWDAGIAP-PVLPQDE 765
            R++     SP  A       S RR S       P  PA     +P P  PQ E
Sbjct: 508 VRRKEEAKESPSAAGPEDKSQSKRRASNEKESAAPASPAPSPAPSPTPAPPQKE 561


>gi|19924099 synapsin I isoform Ia [Homo sapiens]
          Length = 705

 Score = 55.8 bits (133), Expect = 1e-07
 Identities = 69/239 (28%), Positives = 91/239 (38%), Gaps = 34/239 (14%)

Query: 162 PRSPARPQPGEGPGGPG------GPPEVSR----GEE-----GRISESPEVTRLSRGRGR 206
           P +  RP P  GP  PG      GPP   R    G++     G  + SP   RL      
Sbjct: 455 PPAQQRPPPQGGPPQPGPGPQRQGPPLQQRPPPQGQQHLSGLGPPAGSPLPQRLPSPTSA 514

Query: 207 PR--LLTPSPTTDLHSGLQMRRARSPDLFTPLSRPPSPLSLPRPRSAP-ARRPPAPSGDT 263
           P+      +P T    G Q R         P +RPP+  S  R    P A R  + SG  
Sbjct: 515 PQQPASQAAPPTQ-GQGRQSRPVAGGPGAPPAARPPASPSPQRQAGPPQATRQTSVSGPA 573

Query: 264 APPARPHTPLSRI----DVRPPLDWGPQRQTLSRPPTPRRGPPS--------EAGGGKP- 310
            P A    P  +       +PP   GP RQ     P PR GPP+            G+P 
Sbjct: 574 PPKASGAPPGGQQRQGPPQKPPGPAGPTRQASQAGPVPRTGPPTTQQPRPSGPGPAGRPK 633

Query: 311 PRSPQHWSQE--PRTQAHSGSPTYLQLPPRPPGTRASMVLLPGPPLESTFHQSLETDTL 367
           P+  Q  SQ+  P   A +G P + QL      T A  +  P PP  S     ++ +T+
Sbjct: 634 PQLAQKPSQDVPPPATAAAGGPPHPQLNKSQSLTNAFNLPEPAPPRPSLSQDEVKAETI 692



 Score = 38.9 bits (89), Expect = 0.018
 Identities = 68/260 (26%), Positives = 82/260 (31%), Gaps = 82/260 (31%)

Query: 492 AGLGGPQKPPPHTEPDSPSPVLQGEESSERESLPESLELSSPRSPETDWGRPPGGDKDLA 551
           AG    Q+PPP   P  P P  Q +                   P      PP G + L+
Sbjct: 453 AGPPAQQRPPPQGGPPQPGPGPQRQ------------------GPPLQQRPPPQGQQHLS 494

Query: 552 SPHLGLGSPRVSRASSPEGRHLPSPQLGTKAPVARPRMSAQEQLERMRRNQECGRPFPRP 611
               GLG P    A SP  + LPSP    + P ++     Q Q          GR     
Sbjct: 495 ----GLGPP----AGSPLPQRLPSPTSAPQQPASQAAPPTQGQ----------GR----- 531

Query: 612 TSPRLLTLGRTLSPARRQPDVEQRPVVGHSGAQKWLRSSGSWSSPRNTTPYLPTSEGHRE 671
                                + RPV G  GA    R   S S  R   P   T      
Sbjct: 532 ---------------------QSRPVAGGPGAPPAARPPASPSPQRQAGPPQAT------ 564

Query: 672 RVLSLSQALATEASQWHRMMTGGNLDSQGDPLPGVPLPPSDPTRQET---PPPRS-PPVA 727
           R  S+S     +AS        G    QG P    P  P+ PTRQ +   P PR+ PP  
Sbjct: 565 RQTSVSGPAPPKASG----APPGGQQRQGPPQK--PPGPAGPTRQASQAGPVPRTGPPTT 618

Query: 728 NSGSTGFSRRGSGRGGGPTP 747
                     G G  G P P
Sbjct: 619 QQPRPS----GPGPAGRPKP 634



 Score = 38.9 bits (89), Expect = 0.018
 Identities = 43/159 (27%), Positives = 59/159 (37%), Gaps = 25/159 (15%)

Query: 495 GGPQKPPPHTEPDSPSPVLQ-GEESSERESLPESLELSSPRSPETDWGRPPGGDKDLASP 553
           GGP  PP    P SPSP  Q G   + R++      +S P  P+   G PPGG +    P
Sbjct: 538 GGPGAPPAARPPASPSPQRQAGPPQATRQT-----SVSGPAPPKAS-GAPPGGQQRQGPP 591

Query: 554 HLGLGSPRVSRASSPEGRHLPSPQLGT----------KAPVARPR----MSAQEQLERMR 599
               G    +R +S  G   P P+ G             P  RP+        + +    
Sbjct: 592 QKPPGPAGPTRQASQAG---PVPRTGPPTTQQPRPSGPGPAGRPKPQLAQKPSQDVPPPA 648

Query: 600 RNQECGRPFPRPTSPRLLTLGRTL-SPARRQPDVEQRPV 637
                G P P+    + LT    L  PA  +P + Q  V
Sbjct: 649 TAAAGGPPHPQLNKSQSLTNAFNLPEPAPPRPSLSQDEV 687



 Score = 33.5 bits (75), Expect = 0.78
 Identities = 18/63 (28%), Positives = 22/63 (34%)

Query: 703 LPGVPLPPSDPTRQETPPPRSPPVANSGSTGFSRRGSGRGGGPTPWGPAWDAGIAPPVLP 762
           L G+  P   P  Q  P P S P   +       +G GR   P   GP       PP  P
Sbjct: 493 LSGLGPPAGSPLPQRLPSPTSAPQQPASQAAPPTQGQGRQSRPVAGGPGAPPAARPPASP 552

Query: 763 QDE 765
             +
Sbjct: 553 SPQ 555



 Score = 30.4 bits (67), Expect = 6.6
 Identities = 54/203 (26%), Positives = 67/203 (33%), Gaps = 25/203 (12%)

Query: 565 ASSPEGRHLPSPQLGTKAPVARPRMSAQEQLERMRRNQECGRPFPRPTSPRLLTLGRTLS 624
           AS   G H  +P     +P A P       L R    Q  G P  +   P+         
Sbjct: 426 ASPGRGSHGQTP-----SPGALP-------LGRQTSQQPAGPPAQQRPPPQGGPPQPGPG 473

Query: 625 PARRQPDVEQRPVVGHSGAQKWLRSSGSWSSPRNTTPYLPTSEGHRERVLSLSQALATEA 684
           P R+ P ++QRP     G Q          SP       PTS   +      SQA     
Sbjct: 474 PQRQGPPLQQRPPP--QGQQHLSGLGPPAGSPLPQRLPSPTSAPQQPA----SQAAPPTQ 527

Query: 685 SQWH--RMMTGGNLDSQGDPLPGVPLP-----PSDPTRQETPPPRSPPVANSGSTGFSRR 737
            Q    R + GG         P  P P     P   TRQ +    +PP A+    G  +R
Sbjct: 528 GQGRQSRPVAGGPGAPPAARPPASPSPQRQAGPPQATRQTSVSGPAPPKASGAPPGGQQR 587

Query: 738 GSGRGGGPTPWGPAWDAGIAPPV 760
                  P P GP   A  A PV
Sbjct: 588 QGPPQKPPGPAGPTRQASQAGPV 610


>gi|239751637 PREDICTED: hypothetical protein FLJ22184 [Homo
           sapiens]
          Length = 1124

 Score = 55.5 bits (132), Expect = 2e-07
 Identities = 163/656 (24%), Positives = 221/656 (33%), Gaps = 120/656 (18%)

Query: 147 ALGRASRAEGDDYGQPRSP--ARPQPG-EGPGGPGGPPEVSRGEEGRISE-SPEVTRL-S 201
           A+ R SRA G + G PR    ARP+P  EGP        VS   E   +E SP   R  S
Sbjct: 175 AMARRSRAAGTEVGLPRPAPSARPRPPTEGPR-----KSVSSASEHSTTEPSPAARRRPS 229

Query: 202 RGRGRPRLLTPSPTTDLHSGLQMRRARSPDLFTPLSRPPSPLSLPRPRSAPARRPP---A 258
            G G  R  + S ++         R+      TP  R P+  S P+P+   A RPP    
Sbjct: 230 AGGGLQRPASRSLSSSATPLSSPARSGPSARGTP--RAPAHPSQPKPKGLQALRPPQVTP 287

Query: 259 PSGDTAPPARPHTPLSRIDVRPPLDWGPQRQTLSRPPTPRRGPPSEAGGGKP---PRSPQ 315
           P  D AP      PLS   +  P   G + +     P P   PP  A    P   P SP 
Sbjct: 288 PRKDAAPAL---GPLSSSPLATPSPSGTKAR-----PVP---PPDNAATPLPATLPPSPP 336

Query: 316 HWSQEPRTQAHSGSPTYLQLPPRPPGTRASMV--LLPGPPLESTFHQSLETDTLLTKLCG 373
             +  P       +P  LQ  P PP T  S     +  PP+++    SL+T         
Sbjct: 337 LATPLPLAPPSPSAPPSLQTLPSPPATPPSQAPPSMTTPPMQAP--PSLQT--------- 385

Query: 374 QDRLLRRLQEEIDQKQEEKEQLEAALELTRQQLGQATREAGAPGRAWGRQRLLQDRLVSV 433
               +  +Q          +   + L L+     QAT   G+P               ++
Sbjct: 386 ----IPPIQVPHSLTSPSLQAPPSPLALSSL---QATTSLGSP---------------TL 423

Query: 434 RATLCHLTQERERVWDTYSGLEQELGTLRETLEYLLHLGSPQDRVSAQQQLWMVEDTLAG 493
           +AT   LT    +   + +   +   T             P D    Q          A 
Sbjct: 424 QATHSFLTMSPRQTQASLTSPSRPAST-------------PPDSPPLQ----------AP 460

Query: 494 LGGPQKPPPHTEPDSPSPVLQGEESSERESLPESLELSSPRSPETDWGRPP-GGDKDLAS 552
           L  P  PP  T        L    +        SL   SP++P +    PP      LA 
Sbjct: 461 LSLPASPPLQTSLSPAVSPLSSPLTIHPLQALSSLASHSPQAPLSSLIMPPLETQSSLAP 520

Query: 553 PHLGLGSPRVSRASSPEGRHLPS---PQLGT-KAPVARPRMSAQEQLERMRRNQECGRPF 608
           P   L +P  S  ++P   +LPS   P L T  AP+  P +              C  P 
Sbjct: 521 P--SLQTPPAS-LTTPPLENLPSLAPPPLQTASAPLTTPHL----------ETPPCPAPC 567

Query: 609 PRPTSPRLLTLGRTLSPARRQPDVEQRPVVGHSGAQKWLRS---SGSWSSPRNTTPYL-- 663
           P    P  LT     +P+       Q P    S   + L S   S   + P    P L  
Sbjct: 568 PLQAPPSPLTTPPPETPSSIATPPPQAPPALASPPLQGLPSPPLSPLATPPPQAPPXLAL 627

Query: 664 -PTSEGHRERVLSLSQALATEASQWHRMMTGGNLDSQGDPLPGVPLPPSDPTRQETPPPR 722
            P               LAT + Q    +    L +   P      PPS P +    PP 
Sbjct: 628 PPLQAPPSPPASPPLSPLATPSPQAPNALAVHLLQAPFSP------PPSPPVQAPFSPPA 681

Query: 723 SPPVANSGSTGFSRRGSGRGGGP--TPWGPAWDAGIAPPVLPQDEGAWPLRVTLLQ 776
           SPPV+ S +T  S+        P   P  P     ++P   P  +   PL    LQ
Sbjct: 682 SPPVSPS-ATPPSQAPPSLAAPPLQVPPSPPASPPMSPSATPPPQAPPPLAAPPLQ 736



 Score = 50.8 bits (120), Expect = 5e-06
 Identities = 44/154 (28%), Positives = 59/154 (38%), Gaps = 21/154 (13%)

Query: 209 LLTPSPTTDLHSGLQMRRAR-----SPDLFTPLSRPPSPLSLPRPRSAPARRPPAPSGDT 263
           L TPSP       + + +A      SP +  P S P SP   P   + P++ PP+ +   
Sbjct: 645 LATPSPQAPNALAVHLLQAPFSPPPSPPVQAPFSPPASPPVSPSA-TPPSQAPPSLAAPP 703

Query: 264 --APPARPHTPLSRIDVRPPLDWGPQRQT--LSRPPTPRRGPPSEAGGGKPPRSPQHWSQ 319
              PP+ P +P       PP    P      L  PP+P   PP       PPR P   + 
Sbjct: 704 LQVPPSPPASPPMSPSATPPPQAPPPLAAPPLQVPPSPPASPPMSPSATPPPRVPPLLAA 763

Query: 320 EPRTQAHSGSPTYLQLPPRPPGTRASMVLLPGPP 353
            P           LQ+PP PP +     L   PP
Sbjct: 764 PP-----------LQVPPSPPASLPMSPLAKPPP 786



 Score = 50.1 bits (118), Expect = 8e-06
 Identities = 58/205 (28%), Positives = 73/205 (35%), Gaps = 34/205 (16%)

Query: 162 PRSPARPQPGEGPGGPGGPPEVSRGEEGRISESPEVTRLSRGRGRPRLLTPSPTTDLHSG 221
           P SP    P E P     PP     +      SP +  L      P L TP P       
Sbjct: 572 PPSPLTTPPPETPSSIATPPP----QAPPALASPPLQGLPSPPLSP-LATPPPQAPPXLA 626

Query: 222 LQMRRAR-SPDLFTPLSRPPSPLSLPRPRS----------APARRPPAPSGDTAPPARPH 270
           L   +A  SP    P S P SPL+ P P++          AP   PP+P    AP + P 
Sbjct: 627 LPPLQAPPSP----PASPPLSPLATPSPQAPNALAVHLLQAPFSPPPSPPVQ-APFSPPA 681

Query: 271 TPLSRIDVRPPLDWGPQ--RQTLSRPPTPRRGPPSEAGGGKPPRSPQHWSQEPRTQAHSG 328
           +P       PP    P      L  PP+P   PP       PP++P   +  P       
Sbjct: 682 SPPVSPSATPPSQAPPSLAAPPLQVPPSPPASPPMSPSATPPPQAPPPLAAPP------- 734

Query: 329 SPTYLQLPPRPPGTRASMVLLPGPP 353
               LQ+PP PP +         PP
Sbjct: 735 ----LQVPPSPPASPPMSPSATPPP 755



 Score = 50.1 bits (118), Expect = 8e-06
 Identities = 66/213 (30%), Positives = 82/213 (38%), Gaps = 36/213 (16%)

Query: 162 PRSPARPQPGEGPGGPGGPP-EVSRGEEGRISESPEVTRLSRG----RGRPRLLTPSP-T 215
           P SP+   P + P     PP +V          SP  T   +        P  + PSP  
Sbjct: 684 PVSPSATPPSQAPPSLAAPPLQVPPSPPASPPMSPSATPPPQAPPPLAAPPLQVPPSPPA 743

Query: 216 TDLHSGLQMRRARSPDLFT--PLSRPPSP-LSLPRPRSAPARRPPAPSGDTAPPARPHTP 272
           +   S       R P L    PL  PPSP  SLP    +P  +PP      APPA    P
Sbjct: 744 SPPMSPSATPPPRVPPLLAAPPLQVPPSPPASLPM---SPLAKPPPQ----APPALATPP 796

Query: 273 LSRIDVRPPLDW---GPQRQTLSRPPTPRRGPPSEAGGGKPPRSPQHWSQEPRTQAHSGS 329
           L  +   PP  +    P   + S P +P   PP +A    PP       Q P +     S
Sbjct: 797 LQALP-SPPASFPGQAPFSPSASLPMSPLATPPPQA----PPVLAAPLLQVPPSPP--AS 849

Query: 330 PTYLQLPPRPP---------GTRASMVLLPGPP 353
           PT LQ P RPP         G R ++ L PGPP
Sbjct: 850 PT-LQAPRRPPTPGPDTSVSGPRLTLALAPGPP 881



 Score = 47.4 bits (111), Expect = 5e-05
 Identities = 60/200 (30%), Positives = 71/200 (35%), Gaps = 39/200 (19%)

Query: 162 PRSPARPQPGEGPGGPGGPP-EVSRGEEGRISESPEVTRLSRG----RGRPRLLTPSPTT 216
           P SP+   P + P     PP +V          SP  T   R        P  + PSP  
Sbjct: 715 PMSPSATPPPQAPPPLAAPPLQVPPSPPASPPMSPSATPPPRVPPLLAAPPLQVPPSPPA 774

Query: 217 DLH-SGLQMRRARSPDLFT--PLSRPPSPLSLPRPRSAPARRPPAPSGD-------TAPP 266
            L  S L     ++P      PL   PSP     P S P + P +PS         T PP
Sbjct: 775 SLPMSPLAKPPPQAPPALATPPLQALPSP-----PASFPGQAPFSPSASLPMSPLATPPP 829

Query: 267 ARPHT---PLSRIDVRPPLDWGPQRQTLSRPPTPRRGPPSEAGG---------GKPP--- 311
             P     PL ++   PP    P  Q   RPPTP  GP +   G         G PP   
Sbjct: 830 QAPPVLAAPLLQVPPSPPAS--PTLQAPRRPPTP--GPDTSVSGPRLTLALAPGPPPPPS 885

Query: 312 RSPQHWSQEPRTQAHSGSPT 331
           RSP      P    HS S T
Sbjct: 886 RSPSSTLSGPDLAGHSSSAT 905



 Score = 45.4 bits (106), Expect = 2e-04
 Identities = 69/244 (28%), Positives = 88/244 (36%), Gaps = 37/244 (15%)

Query: 130 TYVLAADTLEDLRGWLRALGRASRAEGDDYGQPRS-PARPQPGEGPGG-PGGPPEVSRGE 187
           T  L + TL+    +L    R ++A      +P S P    P + P   P  PP      
Sbjct: 415 TTSLGSPTLQATHSFLTMSPRQTQASLTSPSRPASTPPDSPPLQAPLSLPASPPL----- 469

Query: 188 EGRISESPEVTRLSRG------RGRPRLLTPSPTTDLHSGLQMRRARSPDLFTP-LSRPP 240
             + S SP V+ LS        +    L + SP   L S +         L  P L  PP
Sbjct: 470 --QTSLSPAVSPLSSPLTIHPLQALSSLASHSPQAPLSSLIMPPLETQSSLAPPSLQTPP 527

Query: 241 SPLSLPRPRSAPARRPPAPSGDTAPPARPHTPLSRIDVRPPLDWGPQRQTLSRPPTPR-- 298
           + L+ P   + P+  PP     +AP   PH          PL   P   T   P TP   
Sbjct: 528 ASLTTPPLENLPSLAPPPLQTASAPLTTPHLETPPCPAPCPLQAPPSPLTTPPPETPSSI 587

Query: 299 -----RGPPSEA-----GGGKPPRSPQHWSQEPRTQAHSGSPTYLQLPP--RPPGTRASM 346
                + PP+ A     G   PP SP      P  QA    P  L LPP   PP   AS 
Sbjct: 588 ATPPPQAPPALASPPLQGLPSPPLSP---LATPPPQA----PPXLALPPLQAPPSPPASP 640

Query: 347 VLLP 350
            L P
Sbjct: 641 PLSP 644



 Score = 45.1 bits (105), Expect = 3e-04
 Identities = 51/197 (25%), Positives = 65/197 (32%), Gaps = 37/197 (18%)

Query: 162 PRSPARPQPGEGPGGPGGPPEVSRGEEGRISESPEVTRLSRGRGRPRLLTPSPTTDLHSG 221
           P SP    P + P  P   P VS          P +         P  + PSP       
Sbjct: 664 PFSPPPSPPVQAPFSPPASPPVSPSATPPSQAPPSLA------APPLQVPPSP------- 710

Query: 222 LQMRRARSPDLFTPLSRPPSPLSLPRPRSAPARRPPA----PSGDTAPPARPH-TPLSRI 276
                        P S P SP + P P++ P    P     PS   +PP  P  TP  R+
Sbjct: 711 -------------PASPPMSPSATPPPQAPPPLAAPPLQVPPSPPASPPMSPSATPPPRV 757

Query: 277 DVRPPLDWGPQRQTLSRPPTPRRGPPSEAGGGKPPRSPQHWSQEPRTQAHSGSPTYLQLP 336
              PPL   P  Q    PP+P    P       PP++P   +  P     S   ++    
Sbjct: 758 ---PPLLAAPPLQV---PPSPPASLPMSPLAKPPPQAPPALATPPLQALPSPPASFPGQA 811

Query: 337 PRPPGTRASMVLLPGPP 353
           P  P     M  L  PP
Sbjct: 812 PFSPSASLPMSPLATPP 828



 Score = 37.4 bits (85), Expect = 0.054
 Identities = 72/266 (27%), Positives = 89/266 (33%), Gaps = 57/266 (21%)

Query: 500 PPPHTEPDSPSPVLQGEESSERESLPESLELSSPRSPETDWGRPPGGDKDLASPHL-GLG 558
           PPP   P   +P LQ   S      P SL +S    P      PP     LA+P L  L 
Sbjct: 753 PPPRVPPLLAAPPLQVPPSP-----PASLPMSPLAKP------PPQAPPALATPPLQALP 801

Query: 559 SPRVS---RASSPEGRHLPSPQLGTKAPVARPRMSAQEQLERMRRNQECGRPFPRPTSPR 615
           SP  S   +A       LP   L T  P A P ++A   L ++        P   P SP 
Sbjct: 802 SPPASFPGQAPFSPSASLPMSPLATPPPQAPPVLAAP--LLQV--------PPSPPASP- 850

Query: 616 LLTLGRTLSPARRQPDVEQRPVVGHSGAQKWLRSSGSWSSPRNTTPYL----PTSEGHRE 671
                 TL   RR P     P    SG +  L  +     P + +P      P   GH  
Sbjct: 851 ------TLQAPRRPPT--PGPDTSVSGPRLTLALAPGPPPPPSRSPSSTLSGPDLAGHSS 902

Query: 672 RVLSLSQALATEASQWHRMMTGGNLDSQGDPLPGVPLPPSDPTRQETPPPRSPPVANSGS 731
              S  + L    S       G    +   P P   L    P      P  +PP+A  G+
Sbjct: 903 SATSTPEELRGYDS-------GPEGGAAASPPPDAELAACHPAAWSRGP--APPLAFRGA 953

Query: 732 TGFSRRGSGRGGGPTPWGPAWDAGIA 757
            G           P PW PA   G A
Sbjct: 954 PG----------APLPWPPATGPGSA 969



 Score = 33.9 bits (76), Expect = 0.59
 Identities = 50/217 (23%), Positives = 71/217 (32%), Gaps = 36/217 (16%)

Query: 559 SPRVSRASSPEGRHLPSPQLGTKAPVARPRMSAQEQLERMRRNQECGRPFPRPTSPRLLT 618
           +P+ S  S+   R    P  GT +P    R  A      + R     RP P    PR   
Sbjct: 150 APKRSALSAGARRDTSGPTPGTPSPAMARRSRAAGTEVGLPRPAPSARPRPPTEGPR--- 206

Query: 619 LGRTLSPARRQPDVEQRPVVGHSGAQKWLRSSGSWSSPRNTTPYLPTSEGHRERVLSLSQ 678
             +++S A      E  P                           P++ G  +R    S+
Sbjct: 207 --KSVSSASEHSTTEPSPAARRR----------------------PSAGGGLQR--PASR 240

Query: 679 ALATEASQWHRMMTGGNLDSQGDP-LPGVPLPPSDPTRQETPPPRSPPVANSGSTGFSRR 737
           +L++ A+        G   ++G P  P  P  P     Q   PP+  P     +      
Sbjct: 241 SLSSSATPLSSPARSGP-SARGTPRAPAHPSQPKPKGLQALRPPQVTPPRKDAAPALGPL 299

Query: 738 GSGRGGGPTPWGPAWDAGIAPPVLPQDEGAWPLRVTL 774
            S     P+P G       A PV P D  A PL  TL
Sbjct: 300 SSSPLATPSPSGTK-----ARPVPPPDNAATPLPATL 331


>gi|237757326 synaptojanin 1 isoform d [Homo sapiens]
          Length = 1526

 Score = 55.1 bits (131), Expect = 2e-07
 Identities = 50/141 (35%), Positives = 67/141 (47%), Gaps = 17/141 (12%)

Query: 207  PRLLTPSPTTDLHSGLQMRRARSPDLFTPLSRPPSPLSLP-RPRSAPARRPPAPSGDTAP 265
            P+ L PS ++ L +        SP     +S  P P SLP RP  AP+R P  PS  ++P
Sbjct: 1022 PQHLQPSSSSGLGTSPSSSPRTSPCQSPTISEGPVP-SLPIRPSRAPSRTPGPPSAQSSP 1080

Query: 266  -PARPHTPLSRIDVRPPLDWGPQRQTLSRP------PTPRRGPPSEAGGGKPPRSPQHWS 318
              A+P TPL + D   PL+  P+R    RP      P P + PP  +G  +P  SPQ   
Sbjct: 1081 IDAQPATPLPQKDPAQPLE--PKRPPPPRPVAPPTRPAPPQRPPPPSGRSQP--SPQAGL 1136

Query: 319  QEPRTQAHS-GSPTYLQLPPR 338
              P    +S   PT   +PPR
Sbjct: 1137 AGPGPAGYSTARPT---IPPR 1154



 Score = 47.4 bits (111), Expect = 5e-05
 Identities = 69/241 (28%), Positives = 83/241 (34%), Gaps = 48/241 (19%)

Query: 157  DDYG---QPRSPARPQPGEGPG---GPGGPPEVSRGEEGRISESPEVTRLSRGRGRPRLL 210
            DDY    +   P   QP    G    P   P  S  +   ISE P V  L     R    
Sbjct: 1011 DDYSAEVEELLPQHLQPSSSSGLGTSPSSSPRTSPCQSPTISEGP-VPSLPIRPSRAPSR 1069

Query: 211  TPSPTTDLHSGLQMRRAR---SPDLFTPLS--RPPSPLSLPRP-RSAPARRPPAPSGDTA 264
            TP P +   S +  + A      D   PL   RPP P  +  P R AP +RPP PSG + 
Sbjct: 1070 TPGPPSAQSSPIDAQPATPLPQKDPAQPLEPKRPPPPRPVAPPTRPAPPQRPPPPSGRSQ 1129

Query: 265  P----------PARPHTPLSRIDVRPPLDWGPQ---RQTLSRPPTPRRGPPSEAGGGK-- 309
            P          PA   T    I  R  +   PQ   R +  R     +   SE   G   
Sbjct: 1130 PSPQAGLAGPGPAGYSTARPTIPPRAGVISAPQSHARASAGRLTPESQSKTSETSKGSTF 1189

Query: 310  -----------PPRS----PQHWSQEPRTQA-----HSGSPTYLQLPPRPPGTRASMVLL 349
                       PP+S    P    QEP          SG    L+ PP+PP    S   L
Sbjct: 1190 LPEPLKPQAAFPPQSSLPPPAQRLQEPLVPVAAPMPQSGPQPNLETPPQPPPRSRSSHSL 1249

Query: 350  P 350
            P
Sbjct: 1250 P 1250



 Score = 35.0 bits (79), Expect = 0.27
 Identities = 61/236 (25%), Positives = 86/236 (36%), Gaps = 19/236 (8%)

Query: 501  PPHTEPDSPSPVLQGEESSERESLPESLELSSPRSPETDWGRPPGGDKDLASPHLGLGSP 560
            P H +P S S +     SS R S  +S  +S    P     RP         P     SP
Sbjct: 1022 PQHLQPSSSSGLGTSPSSSPRTSPCQSPTISEGPVPSLPI-RPSRAPSRTPGPPSAQSSP 1080

Query: 561  RVSRASSPEGRHLPSPQLGTKAP-----VARPRMSAQEQLERMRRNQECGRPFPRPTSPR 615
              ++ ++P  +  P+  L  K P     VA P   A  Q    R     GR  P P +  
Sbjct: 1081 IDAQPATPLPQKDPAQPLEPKRPPPPRPVAPPTRPAPPQ----RPPPPSGRSQPSPQAGL 1136

Query: 616  LLTLGRTLSPARRQPDVEQRPVVGHSGAQKWLRSSGSWSSPRNTTPYLPTSEGHRERVLS 675
                    S AR  P +  R  V  S  Q   R+S    +P + +    TS+G       
Sbjct: 1137 AGPGPAGYSTAR--PTIPPRAGV-ISAPQSHARASAGRLTPESQSKTSETSKGST----F 1189

Query: 676  LSQALATEASQWHRMMTGGNLDSQGDPLPGV--PLPPSDPTRQETPPPRSPPVANS 729
            L + L  +A+   +           +PL  V  P+P S P      PP+ PP + S
Sbjct: 1190 LPEPLKPQAAFPPQSSLPPPAQRLQEPLVPVAAPMPQSGPQPNLETPPQPPPRSRS 1245



 Score = 35.0 bits (79), Expect = 0.27
 Identities = 47/202 (23%), Positives = 73/202 (36%), Gaps = 26/202 (12%)

Query: 498  QKPPPHTEPDSPSPVLQGEESSERESLPESLELSSPRSPETDWGRPPGGDKDLASPHLGL 557
            Q  P   +P +P P     +  E +  P    ++ P  P      PP   +   SP  GL
Sbjct: 1077 QSSPIDAQPATPLPQKDPAQPLEPKRPPPPRPVAPPTRPAPPQRPPPPSGRSQPSPQAGL 1136

Query: 558  GSPRVSRASS------PEGRHLPSPQLGTKAPVARPRMSAQEQLERMRRNQECGRPFPRP 611
              P  +  S+      P    + +PQ   +A   R    +Q +     +        P P
Sbjct: 1137 AGPGPAGYSTARPTIPPRAGVISAPQSHARASAGRLTPESQSKTSETSKGSTF---LPEP 1193

Query: 612  TSPRLLTLGRTL--SPARR--QPDVEQRPVVGHSGAQKWL----------RSSGSWSSPR 657
              P+     ++    PA+R  +P V     +  SG Q  L          RSS S  S  
Sbjct: 1194 LKPQAAFPPQSSLPPPAQRLQEPLVPVAAPMPQSGPQPNLETPPQPPPRSRSSHSLPSEA 1253

Query: 658  NTTPYLPT---SEGHRERVLSL 676
            ++ P + T   S+G RE  L +
Sbjct: 1254 SSQPQVKTNGISDGKRESPLKI 1275


>gi|112734870 hypothetical protein LOC57648 [Homo sapiens]
          Length = 1094

 Score = 55.1 bits (131), Expect = 2e-07
 Identities = 63/234 (26%), Positives = 79/234 (33%), Gaps = 41/234 (17%)

Query: 149 GRASRAEGDDYGQPRSPAR-------PQPGEGPGGPGGPPEVSRGEEGRISESPEVTRLS 201
           G    ++G   GQP S          PQ G G G P G       +   I  S +++   
Sbjct: 429 GSTLSSKGGSEGQPESSTASNSVVPPPQGGSGRGSPSGGSTAEASDTLSIRSSGQLS--G 486

Query: 202 RGRGRPRLLTPSPTTDLHSGLQMRRARSPDLFTPLSRPPSPL-----SLPRPRS------ 250
           R     +L  P P       L  R    PD   PL  PP P       LPRP +      
Sbjct: 487 RSVSLRKLKRPPPPPRRTHSLHQRGLAVPD--GPLGLPPKPERKQQPQLPRPPTTGGSEG 544

Query: 251 ---APARRPPA--------PSGDTAPPARPHTPLSRIDVRPPLDWGPQRQTLSRPPTPRR 299
              AP    PA        P G   PP  P   LS     P   +  Q  T + PP    
Sbjct: 545 AGAAPCPPNPANSWVPGLSPGGSRRPPRSPERTLS-----PSSGYSSQSGTPTLPPKGLA 599

Query: 300 GPPSEAGGGKPPRSPQHWSQEPRTQAHSGSPTYL---QLPPRPPGTRASMVLLP 350
           GPP+  G  +PP+  +  S      + S S T L      P P       +L P
Sbjct: 600 GPPASPGKAQPPKPERVTSLRSPGASVSSSLTSLCSSSSDPAPSDRSGPQILTP 653



 Score = 38.1 bits (87), Expect = 0.032
 Identities = 58/212 (27%), Positives = 71/212 (33%), Gaps = 44/212 (20%)

Query: 156 GDDYGQPRSPARPQPGEGPGG------PGGP----PEVSRGEEGRISESPEVTRLSRGRG 205
           GD +  P  P  P P   P        P  P    P V  G       SP+         
Sbjct: 655 GDRFVIPPHPKVPAPFSPPPSKPRSPNPAAPALAAPAVVPGPVSTTDASPQSP------- 707

Query: 206 RPRLLTPSPTTDLHSGLQMRRARSPDLFTPLSRPPSPLSLPRPRSAPARRPPAPSGDTAP 265
                 P+P T L + LQ     SP +    S PPSP     P   P ++P       + 
Sbjct: 708 ------PTPQTTL-TPLQ----ESPVISKDQSPPPSPPPSYHPPPPPTKKPEVVVEAPSA 756

Query: 266 PARPHTPLSRIDVRPPLDWGPQRQTLSRPPTPRRGPPSEAGGGKPPRSPQHWSQEPR--- 322
                 PL   +  PP    P+ Q LS    P   PP EA        P   S  P    
Sbjct: 757 SETAEEPLQDPNWPPPPPPAPEEQDLSMADFP---PPEEAFFSVASPEPAGPSGSPELVS 813

Query: 323 -TQAHSGSPTYLQLPPRPPGTRASMVLLPGPP 353
              A S S T LQ+  +PPG+       P PP
Sbjct: 814 SPAASSSSATALQI--QPPGS-------PDPP 836



 Score = 34.3 bits (77), Expect = 0.46
 Identities = 29/100 (29%), Positives = 39/100 (39%), Gaps = 5/100 (5%)

Query: 493 GLGGPQKPPPHTEPDSPSPV--LQGEESSERESLPESLELSSPRSPETDWGRP---PGGD 547
           GL GP   P   +P  P  V  L+   +S   SL      SS  +P    G     P GD
Sbjct: 597 GLAGPPASPGKAQPPKPERVTSLRSPGASVSSSLTSLCSSSSDPAPSDRSGPQILTPLGD 656

Query: 548 KDLASPHLGLGSPRVSRASSPEGRHLPSPQLGTKAPVARP 587
           + +  PH  + +P     S P   +  +P L   A V  P
Sbjct: 657 RFVIPPHPKVPAPFSPPPSKPRSPNPAAPALAAPAVVPGP 696



 Score = 33.9 bits (76), Expect = 0.59
 Identities = 39/133 (29%), Positives = 50/133 (37%), Gaps = 23/133 (17%)

Query: 177  PGGPPEVSRGEEGRISESPEVTR---LSRGRGRPRLLTP-SPTT--DLHSGLQMRRARSP 230
            P GPPE     E R  +SP  T     S+G  + +L  P SP T  DL   L        
Sbjct: 952  PNGPPEA----EPRPPQSPASTASFIFSKGSRKLQLERPVSPETQADLQRNLVAELRSIS 1007

Query: 231  DLFTPLSRPPSPLSLPRPRSAPARRPPA---PSGDTAPPARPHTPLSRIDVRPPLDWGPQ 287
            +      RPP       P+ +P   PP    PS    PPA P  P +     PP +  P 
Sbjct: 1008 E-----QRPPQA-----PKKSPKAPPPVARKPSVGVPPPASPSYPRAEPLTAPPTNGLPH 1057

Query: 288  RQTLSRPPTPRRG 300
             Q  ++      G
Sbjct: 1058 TQDRTKRELAENG 1070


>gi|237757312 synaptojanin 1 isoform c [Homo sapiens]
          Length = 1295

 Score = 54.7 bits (130), Expect = 3e-07
 Identities = 49/140 (35%), Positives = 66/140 (47%), Gaps = 20/140 (14%)

Query: 207  PRLLTPSPTTDLHSGLQMRRARSPDLFTPLSRPPSPLSLP-RPRSAPARRPPAPSGDTAP 265
            P+ L PS ++ L +        SP     +S  P P SLP RP  AP+R P  PS  ++P
Sbjct: 1027 PQHLQPSSSSGLGTSPSSSPRTSPCQSPTISEGPVP-SLPIRPSRAPSRTPGPPSAQSSP 1085

Query: 266  -PARPHTPLSRIDVRPPLDWGPQRQTLSRPPTPRR-GPPSEAGGGKPPRSPQHWSQEPRT 323
              A+P TPL + D   PL+         RPP PR   PP+      PP+ P      P +
Sbjct: 1086 IDAQPATPLPQKDPAQPLE-------PKRPPPPRPVAPPTRPA---PPQRP-----PPPS 1130

Query: 324  QAHSGSPTYLQL-PPRPPGT 342
             A S +PT  +   P+ PGT
Sbjct: 1131 GARSPAPTRKEFGAPKSPGT 1150



 Score = 40.8 bits (94), Expect = 0.005
 Identities = 72/267 (26%), Positives = 87/267 (32%), Gaps = 74/267 (27%)

Query: 157  DDYG---QPRSPARPQPGEGPG---GPGGPPEVSRGEEGRISESPEVTRLSRGRGRPRLL 210
            DDY    +   P   QP    G    P   P  S  +   ISE P V  L     R    
Sbjct: 1016 DDYSAEVEELLPQHLQPSSSSGLGTSPSSSPRTSPCQSPTISEGP-VPSLPIRPSRAPSR 1074

Query: 211  TPSPTTDLHSGLQMRRAR---SPDLFTPLS--RPPSPLSLPRP-RSAPARRPPAPSGDTA 264
            TP P +   S +  + A      D   PL   RPP P  +  P R AP +RPP PSG  +
Sbjct: 1075 TPGPPSAQSSPIDAQPATPLPQKDPAQPLEPKRPPPPRPVAPPTRPAPPQRPPPPSGARS 1134

Query: 265  P-PAR-----PHTP-------LSRIDVRPPLDW---GPQRQTLSRPPTPRRG-------- 300
            P P R     P +P       + R    P       GP   + +RP  P R         
Sbjct: 1135 PAPTRKEFGAPKSPGTTRKDNIGRSQPSPQAGLAGPGPAGYSTARPTIPPRAGVISAPQS 1194

Query: 301  ---------------PPSEAGGGK-------------PPRS----PQHWSQEPRTQA--- 325
                             SE   G              PP+S    P    QEP       
Sbjct: 1195 HARASAGRLTPESQSKTSETSKGSTFLPEPLKPQAAFPPQSSLPPPAQRLQEPLVPVAAP 1254

Query: 326  --HSGSPTYLQLPPRPPGTRASMVLLP 350
               SG    L+ PP+PP    S   LP
Sbjct: 1255 MPQSGPQPNLETPPQPPPRSRSSHSLP 1281



 Score = 33.9 bits (76), Expect = 0.59
 Identities = 53/203 (26%), Positives = 66/203 (32%), Gaps = 37/203 (18%)

Query: 158  DYGQPRSPARPQPGEGPGGPGGPPEVSRGEEGRISESPEVTRLSRGRGRPRLLT------ 211
            D  QP  P RP P      P  P    R      + SP  TR   G  +    T      
Sbjct: 1098 DPAQPLEPKRPPPPRPVAPPTRPAPPQRPPPPSGARSPAPTRKEFGAPKSPGTTRKDNIG 1157

Query: 212  ---PSPTTDL----HSGLQMRRARSPDLFTPLSRPPSPLSLPRPRSAPARRPPAPSGDTA 264
               PSP   L     +G    R   P     +S P S       R++  R  P     T+
Sbjct: 1158 RSQPSPQAGLAGPGPAGYSTARPTIPPRAGVISAPQS-----HARASAGRLTPESQSKTS 1212

Query: 265  PPARPHT----PLSRIDVRPP-LDWGPQRQTLSRP------PTPRRGPPS--EAGGGKPP 311
              ++  T    PL      PP     P  Q L  P      P P+ GP    E     PP
Sbjct: 1213 ETSKGSTFLPEPLKPQAAFPPQSSLPPPAQRLQEPLVPVAAPMPQSGPQPNLETPPQPPP 1272

Query: 312  RS------PQHWSQEPRTQAHSG 328
            RS      P   S +P+ +  SG
Sbjct: 1273 RSRSSHSLPSEASSQPQQEQPSG 1295



 Score = 32.3 bits (72), Expect = 1.7
 Identities = 63/258 (24%), Positives = 88/258 (34%), Gaps = 37/258 (14%)

Query: 501  PPHTEPDSPSPVLQGEESSERESLPES----------LELSSPRSPETDWGRP------- 543
            P H +P S S +     SS R S  +S          L +   R+P    G P       
Sbjct: 1027 PQHLQPSSSSGLGTSPSSSPRTSPCQSPTISEGPVPSLPIRPSRAPSRTPGPPSAQSSPI 1086

Query: 544  ------PGGDKDLASPHLGLGSPRVSRASSPEGR----HLPSPQLGTKAPVARPRMSAQE 593
                  P   KD A P L    P   R  +P  R      P P  G ++P    +     
Sbjct: 1087 DAQPATPLPQKDPAQP-LEPKRPPPPRPVAPPTRPAPPQRPPPPSGARSPAPTRKEFGAP 1145

Query: 594  QLERMRRNQECGRPFPRPTSPRLLTLGRTLSPARRQPDVEQRPVVGHSGAQKWLRSSGSW 653
            +     R    GR  P P +          S AR  P +  R  V  S  Q   R+S   
Sbjct: 1146 KSPGTTRKDNIGRSQPSPQAGLAGPGPAGYSTAR--PTIPPRAGV-ISAPQSHARASAGR 1202

Query: 654  SSPRNTTPYLPTSEGHRERVLSLSQALATEASQWHRMMTGGNLDSQGDPLPGV--PLPPS 711
             +P + +    TS+G       L + L  +A+   +           +PL  V  P+P S
Sbjct: 1203 LTPESQSKTSETSKGST----FLPEPLKPQAAFPPQSSLPPPAQRLQEPLVPVAAPMPQS 1258

Query: 712  DPTRQETPPPRSPPVANS 729
             P      PP+ PP + S
Sbjct: 1259 GPQPNLETPPQPPPRSRS 1276



 Score = 30.8 bits (68), Expect = 5.0
 Identities = 29/125 (23%), Positives = 45/125 (36%), Gaps = 25/125 (20%)

Query: 497  PQKPPPHTEPDSPSPVLQGEESSERESLPESLELSSPRSPETDWGRPPGGDKDLASPHLG 556
            PQ+PPP +   SP+P  +              E  +P+SP T   R     +   SP  G
Sbjct: 1123 PQRPPPPSGARSPAPTRK--------------EFGAPKSPGTT--RKDNIGRSQPSPQAG 1166

Query: 557  LGSPRVSRASS------PEGRHLPSPQLGTKAPVARPRMSAQEQLERMRRNQECGRPFPR 610
            L  P  +  S+      P    + +PQ   +A   R    +Q +     +        P 
Sbjct: 1167 LAGPGPAGYSTARPTIPPRAGVISAPQSHARASAGRLTPESQSKTSETSKGSTF---LPE 1223

Query: 611  PTSPR 615
            P  P+
Sbjct: 1224 PLKPQ 1228


>gi|41393057 connector enhancer of kinase suppressor of Ras 2 [Homo
           sapiens]
          Length = 1034

 Score = 54.7 bits (130), Expect = 3e-07
 Identities = 29/93 (31%), Positives = 50/93 (53%), Gaps = 6/93 (6%)

Query: 59  GWLHKQDSSGL---RLWKRRWFVLSGHCLFYYKDSREESVLGSVLLPSYNIRPDGPGAPR 115
           GWL K+  +     + WK+ WFVL    L++Y +  +E   G + LP + I  D     R
Sbjct: 575 GWLWKKKDAKSYFSQKWKKYWFVLKDASLYWYINEEDEKAEGFISLPEFKI--DRASECR 632

Query: 116 GRRFTFTAEHPGMRTYVLAADTLEDLRGWLRAL 148
            +++ F A HP ++++  AA+ L+D+  WL  +
Sbjct: 633 -KKYAFKACHPKIKSFYFAAEHLDDMNRWLNRI 664


>gi|110832843 TBP-associated factor 4 [Homo sapiens]
          Length = 1085

 Score = 54.3 bits (129), Expect = 4e-07
 Identities = 61/226 (26%), Positives = 85/226 (37%), Gaps = 49/226 (21%)

Query: 168 PQPGEGPGGPGGP--PEVSRGEEGRISE----SPEVTRLSRGRGRPRLLTPSPTTDLHSG 221
           P PG GPG P GP   +   G    ++     +P V+ ++ G   P  L P P       
Sbjct: 180 PGPGPGPGKPAGPGAAQTLNGSAALLNSHHAAAPAVSLVNNG---PAALLPLPKPAAPGT 236

Query: 222 LQMRRARSPDLFTPLSRPPSPLSLPRPRSAPARRPPAPSGDTAPPARPHTPLSRIDVRPP 281
           +     ++P  F   + PP+P + P P +APA   PA     APP  P  P         
Sbjct: 237 V----IQTPP-FVGAAAPPAPAA-PSPPAAPAPAAPA----AAPPPPPPAPA-------- 278

Query: 282 LDWGPQRQTLSRPPTPRRGPPSEAGGGKPPRSPQHWSQ---EPRTQAHSGSPTYLQLPPR 338
                   TL+RPP    GPP+ A    PP + Q+       P     +G P  +   P 
Sbjct: 279 --------TLARPPGHPAGPPTAAPAVPPPAAAQNGGSAGAAPAPAPAAGGPAGVSGQPG 330

Query: 339 P--------PGTRA---SMVLLPGPPLESTFHQSLETDTLLTKLCG 373
           P        PG +A     V+   PP   T   S    T  + + G
Sbjct: 331 PGAAAAAPAPGVKAESPKRVVQAAPPAAQTLAASGPASTAASMVIG 376



 Score = 36.2 bits (82), Expect = 0.12
 Identities = 56/212 (26%), Positives = 79/212 (37%), Gaps = 28/212 (13%)

Query: 145 LRALGRASRAEGDDYGQPRSPARPQPGE-GPGGPGGPPEVSRGEEGRISESPEVTRLSRG 203
           L A G AS A     G     A P P    P  PG P  + +G  G +++S     LSR 
Sbjct: 361 LAASGPASTAASMVIGPTMQGALPSPAAVPPPAPGTPTGLPKGAAGAVTQS-----LSR- 414

Query: 204 RGRPRLLTPSPTTDLHSGLQMRRARSPDLFTP-LSRPPSPLSLPRPRSAPARRPPAPSGD 262
                  TP+ TT   SG+  R   +P +  P L +PP   +  +    P       S +
Sbjct: 415 -------TPTATT---SGI--RATLTPTVLAPRLPQPPQNPTNIQNFQLPPGMVLVRSEN 462

Query: 263 TAPPARPHTPLSRIDVRPPLDWGPQRQTLSRPPTPRRGPPSEAGGGKPPRSPQHWSQ-EP 321
                 P   L+++  +      PQ     RP TP   PP +    + P +P    Q  P
Sbjct: 463 GQLLMIPQQALAQMQAQAHAQ--PQTTMAPRPATPTSAPPVQISTVQAPGTPIIARQVTP 520

Query: 322 RTQAHSGSPTYLQLPP-----RPPGTRASMVL 348
            T     S     + P     R PG +  +VL
Sbjct: 521 TTIIKQVSQAQTTVQPSATLQRSPGVQPQLVL 552



 Score = 33.5 bits (75), Expect = 0.78
 Identities = 51/184 (27%), Positives = 61/184 (33%), Gaps = 24/184 (13%)

Query: 171 GEGPGGPG-GPPEVSRGEEGRISESPEVTRLSRGRGRP-RLLTPSPTTDL---HSGLQMR 225
           G   G  G GP   + G  G   E P   R   G G P R   PSP   L          
Sbjct: 65  GSPAGAAGAGPAAPAEGAPGAAPEPPPAGRARPGGGGPQRPGPPSPRRPLVPAGPAPPAA 124

Query: 226 RARSPDLFTPLSRPPSPLSLPRPRSAPARRPPAPSGDTAPPARPHTPLSRIDVRPPLDWG 285
           + R P    P     S   +P   +  A   PAP+G  A PA P    +R    P    G
Sbjct: 125 KLRPP----PEGSAGSCAPVPAAAAVAAGPEPAPAG-PAKPAGPAALAARAGPGPGPGPG 179

Query: 286 PQRQTLSRPPTPRRGPPSEAG-----GGKPPRSPQHWSQEPRTQAHSGSPTYLQLPPRP- 339
           P        P P  G P+  G      G       H +  P     +  P  L   P+P 
Sbjct: 180 P-------GPGPGPGKPAGPGAAQTLNGSAALLNSHHAAAPAVSLVNNGPAALLPLPKPA 232

Query: 340 -PGT 342
            PGT
Sbjct: 233 APGT 236



 Score = 32.0 bits (71), Expect = 2.3
 Identities = 28/82 (34%), Positives = 32/82 (39%), Gaps = 11/82 (13%)

Query: 693 GGNLDSQGDPLPGVPLPPSDPTRQETPPP---RSPPVANSGSTGFSRRGSGRGGG--PTP 747
           GG     G P P  PL P+ P     PP    R PP  ++GS       +    G  P P
Sbjct: 99  GGGPQRPGPPSPRRPLVPAGP----APPAAKLRPPPEGSAGSCAPVPAAAAVAAGPEPAP 154

Query: 748 WGPAWDAGIAPPVLPQDEGAWP 769
            GPA  AG  P  L    G  P
Sbjct: 155 AGPAKPAG--PAALAARAGPGP 174



 Score = 30.8 bits (68), Expect = 5.0
 Identities = 69/311 (22%), Positives = 100/311 (32%), Gaps = 62/311 (19%)

Query: 162 PRSPARPQPGEGPGGPGGPPEVSRG--------EEGRISESPEVTRLSRG----RGRP-- 207
           P  PA       PG P GPP  +            G    +P     + G     G+P  
Sbjct: 272 PPPPAPATLARPPGHPAGPPTAAPAVPPPAAAQNGGSAGAAPAPAPAAGGPAGVSGQPGP 331

Query: 208 --RLLTPSPTTDLHSGLQMRRARSPDLFTPLSRPPSPL------------SLPRPRSAPA 253
                 P+P     S  ++ +A  P   T  +  P+              +LP P + P 
Sbjct: 332 GAAAAAPAPGVKAESPKRVVQAAPPAAQTLAASGPASTAASMVIGPTMQGALPSPAAVPP 391

Query: 254 RRPPAPSGDTAPPARPHTPLSRIDVRPPLDWGPQRQTLS------RPPTPRRGPPSEAGG 307
             P  P+G   P          +   P       R TL+      R P P + P +    
Sbjct: 392 PAPGTPTG--LPKGAAGAVTQSLSRTPTATTSGIRATLTPTVLAPRLPQPPQNPTNIQNF 449

Query: 308 GKPP-----RS--------PQHWSQEPRTQAHSGSPTYLQLPPRP------PGTRASMVL 348
             PP     RS        PQ    + + QAH+   T   + PRP      P  + S V 
Sbjct: 450 QLPPGMVLVRSENGQLLMIPQQALAQMQAQAHAQPQT--TMAPRPATPTSAPPVQISTVQ 507

Query: 349 LPGPPLESTFHQSLETDTLLTKLCGQDRLLRRLQEEIDQKQEEKEQLEAALELTRQQLGQ 408
            PG P+ +       T T + K   Q +   +    + +    + QL          LG 
Sbjct: 508 APGTPIIA----RQVTPTTIIKQVSQAQTTVQPSATLQRSPGVQPQLVLGGAAQTASLGT 563

Query: 409 ATR-EAGAPGR 418
           AT  + G P R
Sbjct: 564 ATAVQTGTPQR 574


>gi|54860079 nadrin isoform 1 [Homo sapiens]
          Length = 881

 Score = 54.3 bits (129), Expect = 4e-07
 Identities = 60/218 (27%), Positives = 82/218 (37%), Gaps = 39/218 (17%)

Query: 161 QPRSPARPQPGEGPGGPGGPPEVSRGEE----GRISESPEVTRL--SRGRGRP------- 207
           QP  P        P GP  PP+ SR E     G +  S  +     S G G P       
Sbjct: 524 QPPLPPTDGSTVVPAGPEPPPQSSRAESSSGGGTVPSSAGILEQGPSPGDGSPPKPKDPV 583

Query: 208 RLLTPSP---TTDLHSGLQMRRARSPDLFTPLSRP-----PSPLSLPRPRSAPARRPPAP 259
               P+P    + + SG    +A +      + +P     PSP +L R    PA  PP P
Sbjct: 584 SAAVPAPGRNNSQIASGQNQPQAAAGSHQLSMGQPHNAAGPSPHTLRRAVKKPAPAPPKP 643

Query: 260 SGDTAPPARPHTPLSRIDVRPPLDWGPQRQTLSRPPTPRRGPPSEAGGGKPPRSPQHWSQ 319
                PP  P    S    + P    P      +PPT    PP++  G +PP  P   SQ
Sbjct: 644 GNP--PPGHPGGQSSSGTSQHPPSLSP------KPPTRSPSPPTQHTG-QPPGQPSAPSQ 694

Query: 320 EPRTQAHSGSPTYLQLPPRPPGTRASMVLLPGPPLEST 357
               + +S S + +Q P  PP         P PP ++T
Sbjct: 695 LSAPRRYSSSLSPIQAPNHPP---------PQPPTQAT 723



 Score = 49.3 bits (116), Expect = 1e-05
 Identities = 57/222 (25%), Positives = 74/222 (33%), Gaps = 52/222 (23%)

Query: 160 GQPRSPARP----------QPGEGPGGPGGPPEVSRGEEGRISESPEVTRLSRGRGRPRL 209
           GQP + A P          +P   P  PG PP    G +     S     LS    +P  
Sbjct: 616 GQPHNAAGPSPHTLRRAVKKPAPAPPKPGNPPPGHPGGQSSSGTSQHPPSLSP---KPPT 672

Query: 210 LTPSPTTDLHSGLQMRRARSPDLFTPLSRPPSPLSLPRPR---------SAPARRPPAPS 260
            +PSP T  H+G             P  +P +P  L  PR          AP   PP P 
Sbjct: 673 RSPSPPTQ-HTG------------QPPGQPSAPSQLSAPRRYSSSLSPIQAPNHPPPQPP 719

Query: 261 GDTAP----------PARPHTPLSRIDVRPPLDWGPQRQT-LSRPPTPRRGP----PSEA 305
               P          P  P    S   +  P    PQ  T  S PP  ++ P    P   
Sbjct: 720 TQATPLMHTKPNSQGPPNPMALPSEHGLEQPSHTPPQTPTPPSTPPLGKQNPSLPAPQTL 779

Query: 306 GGGKPPRSPQHWS--QEPRTQAHSGSPTYLQLPPRPPGTRAS 345
            GG P  +  H      PR      +   +  PP+PPG  ++
Sbjct: 780 AGGNPETAQPHAGTLPRPRPVPKPRNRPSVPPPPQPPGVHSA 821



 Score = 36.2 bits (82), Expect = 0.12
 Identities = 61/270 (22%), Positives = 87/270 (32%), Gaps = 54/270 (20%)

Query: 493 GLGGPQKPPPHTEPDSPSPVLQGEESSERESLPES------LELSSPRS---PETDWGRP 543
           G G P KP        P+P     + +  ++ P++      L +  P +   P     R 
Sbjct: 572 GDGSPPKPKDPVSAAVPAPGRNNSQIASGQNQPQAAAGSHQLSMGQPHNAAGPSPHTLRR 631

Query: 544 PGGDKDLASPHLGLGSPRVSRASSPEGRHLPSPQLGTKAPVARPRMSAQEQLERMRRNQE 603
                  A P  G   P      S  G     P L  K P   P    Q           
Sbjct: 632 AVKKPAPAPPKPGNPPPGHPGGQSSSGTSQHPPSLSPKPPTRSPSPPTQHT--------- 682

Query: 604 CGRPFPRPTSPRLLTLGR----TLSPARR------QPDVEQRPVVGHSGAQKW------L 647
            G+P  +P++P  L+  R    +LSP +       QP  +  P++      +       L
Sbjct: 683 -GQPPGQPSAPSQLSAPRRYSSSLSPIQAPNHPPPQPPTQATPLMHTKPNSQGPPNPMAL 741

Query: 648 RSSGSWSSPRNTTPYLPTSE-----GHRERVLSLSQALATEASQWHRMMTGGNLDSQGDP 702
            S      P +T P  PT       G +   L   Q LA           GGN ++    
Sbjct: 742 PSEHGLEQPSHTPPQTPTPPSTPPLGKQNPSLPAPQTLA-----------GGNPETAQPH 790

Query: 703 LPGVPLP---PSDPTRQETPPPRSPPVANS 729
              +P P   P    R   PPP  PP  +S
Sbjct: 791 AGTLPRPRPVPKPRNRPSVPPPPQPPGVHS 820


>gi|210032580 SET domain containing 1B [Homo sapiens]
          Length = 1923

 Score = 54.3 bits (129), Expect = 4e-07
 Identities = 75/275 (27%), Positives = 96/275 (34%), Gaps = 47/275 (17%)

Query: 107  RPDGPGAPRGRRFTFTAEHPGMRTYVLAADTLEDLRGWLRALGRASRAEGDDYGQPRSPA 166
            RP  P +P     T  A HP +    LA D      G   +L ++   E           
Sbjct: 1286 RPPRPPSPPPEPETTDASHPSVPPEPLAEDHPPHTPGLCGSLAKSQSTE----------- 1334

Query: 167  RPQPGEGPGGPGGPPEVSRGEEGRISESPEVTRLSRGRGRPRLLTPSPTTDLHSGLQMRR 226
                   P  PGG P +S G  G    SP+V       G P    P+P+  L SG   R 
Sbjct: 1335 -----TVPATPGGEPPLSGGSSGLSLSSPQVP------GSP-FSYPAPSPSLSSGGLPRT 1382

Query: 227  ARSPDLFTP-LSRPPSPLSLPRPRSAPARRPPAPSGDTAPPARPHTPLS---RIDVRPPL 282
                  FTP  S P  PL LP     P  R    SG  A P    T L     + +  PL
Sbjct: 1383 PGRDFSFTPTFSEPSGPLLLP-VCPLPTGRRDERSGPLASPVLLETGLPLPLPLPLPLPL 1441

Query: 283  DWGPQRQTLSRPPTP----------RRGPPSEAGGGKPPRSPQHWSQEPRTQAHSGSPTY 332
                  +  +R PTP             PP +   G+P RSP      P   +  G    
Sbjct: 1442 ALPAVLRAQARAPTPLPPLLPAPLASCPPPMKRKPGRPRRSP------PSMLSLDGP--- 1492

Query: 333  LQLPPRPPGTRASMVLLPGPPLESTFHQSLETDTL 367
            L  PP        ++LLPG P    F  + +  T+
Sbjct: 1493 LVRPPAGAALGRELLLLPGQPQTPVFPSTHDPRTV 1527



 Score = 42.7 bits (99), Expect = 0.001
 Identities = 49/175 (28%), Positives = 59/175 (33%), Gaps = 35/175 (20%)

Query: 162 PRSPARPQPGEGPGGPGGPP-----------EVSRGEEGRISESPEVTRLSRGRGRPRLL 210
           P  PA P   E PG P GPP             + G      +SP    L      P   
Sbjct: 436 PLPPAEPLAKEKPGTPPGPPPPDTNSMELGGRPTFGWSPEPCDSPGTPTLESSPAGPEKP 495

Query: 211 TPSPTTDLHSGLQMRRA-----RSPDLFTPLSRPPSPLSLPRPRSAP-----ARRPPAPS 260
             S  + +   L+ +R      R PD  T L    SP+S    + +P         P   
Sbjct: 496 HDSLDSRIEMLLKEQRTKLLFLREPDSDTELQMEGSPISSSSSQLSPLAPFGTNSQPGFR 555

Query: 261 GDTAPPARPH---------TPLSRIDVRPPLDWGPQRQTLSRPPTPRRGPPSEAG 306
           G T P +RP          TPL   D    LD G     L   P P  GPP  AG
Sbjct: 556 GPTPPSSRPSSTGLEDISPTPLPDSDEDEELDLG-----LGPRPPPEPGPPDPAG 605



 Score = 39.3 bits (90), Expect = 0.014
 Identities = 49/185 (26%), Positives = 62/185 (33%), Gaps = 36/185 (19%)

Query: 167 RPQPGEGPGGPGG----PPEVSR---GEEGRISESPEVTRLSRGRGRPRLLTPSPTTDLH 219
           RP P  GP  P G      EV+    G+    SE  +  + S G          P+  + 
Sbjct: 593 RPPPEPGPPDPAGLLSQTAEVALDLVGDRTPTSEKMDEGQQSSGEDMEISDDEMPSAPIT 652

Query: 220 SGLQMRRARSPDLFTPLSRP---PSPLSLPRPRSAPARRPPAPSGDTAPPARPHTPLSRI 276
           S         P + TP +     PS L+   P   P   PP P     PP +P  P+   
Sbjct: 653 SA----DCPKPMVVTPGAAAVAAPSVLAPTLPLPPPPGFPPLPPPPPPPPPQPGFPMPPP 708

Query: 277 DVRPPLDWGPQRQTLSRPPTPRRGPPSEAGGGKPPRSPQHWSQEPRTQAHSGSPTYLQLP 336
              PP    P    ++ PP P   PP     G PP                  P    LP
Sbjct: 709 LPPPPPPPPPAHPAVTVPPPPLPAPP-----GVPP-----------------PPILPPLP 746

Query: 337 PRPPG 341
           P PPG
Sbjct: 747 PFPPG 751



 Score = 37.7 bits (86), Expect = 0.041
 Identities = 70/238 (29%), Positives = 83/238 (34%), Gaps = 59/238 (24%)

Query: 170  PGEGPGGPGGPP-EVSRGEEGRISESPEVTRLSRGRGRPRLLTPSPTT---DLHSGLQMR 225
            P E P     PP  V   E     E PE   LS+      LL+P P     +    L   
Sbjct: 1200 PEERPSMLDEPPLPVGVEEPADSREPPEEPGLSQEGAM--LLSPEPPAKEVEARPPLSPE 1257

Query: 226  RARSPDLFTPLSRPPSPLSLPRPRSAP-----ARRPPAP---------SGDTAPPA---- 267
            RA   DL      P  P+ LP P   P       RPP+P         S  + PP     
Sbjct: 1258 RAPEHDLEV---EPEPPMMLPLPLQPPLPPPRPPRPPSPPPEPETTDASHPSVPPEPLAE 1314

Query: 268  --RPHTP-----LSRIDV----------RPPLDWGPQRQTLSRPPTP------RRGPPSE 304
               PHTP     L++              PPL  G    +LS P  P          PS 
Sbjct: 1315 DHPPHTPGLCGSLAKSQSTETVPATPGGEPPLSGGSSGLSLSSPQVPGSPFSYPAPSPSL 1374

Query: 305  AGGGKPPRSPQHWSQEPRTQAHSGSPTYLQLPPRPPGTR-------ASMVLL-PGPPL 354
            + GG P    + +S  P     SG P  L + P P G R       AS VLL  G PL
Sbjct: 1375 SSGGLPRTPGRDFSFTPTFSEPSG-PLLLPVCPLPTGRRDERSGPLASPVLLETGLPL 1431



 Score = 35.0 bits (79), Expect = 0.27
 Identities = 75/287 (26%), Positives = 95/287 (33%), Gaps = 68/287 (23%)

Query: 497  PQKPPPHTEPDSPSPVLQGEESSERESLPESL-------------ELSSPRSPETDWGRP 543
            P  PP    P SP P  +  ++S     PE L              L+  +S ET     
Sbjct: 1281 PLPPPRPPRPPSPPPEPETTDASHPSVPPEPLAEDHPPHTPGLCGSLAKSQSTET-VPAT 1339

Query: 544  PGGDKDLA--SPHLGLGSPRVSRASSPEGRHLPSPQLG----------------TKAPVA 585
            PGG+  L+  S  L L SP+V    SP     PSP L                 T +  +
Sbjct: 1340 PGGEPPLSGGSSGLSLSSPQV--PGSPFSYPAPSPSLSSGGLPRTPGRDFSFTPTFSEPS 1397

Query: 586  RPRMSAQEQLERMRRNQ-----------ECGRPFPRPTS-PRLLTLGRTLSPARRQPD-- 631
             P +     L   RR++           E G P P P   P  L L   L    R P   
Sbjct: 1398 GPLLLPVCPLPTGRRDERSGPLASPVLLETGLPLPLPLPLPLPLALPAVLRAQARAPTPL 1457

Query: 632  VEQRPVVGHSGAQKWLRSSGSWSSPRNTTPYLPTSEG-----------HRERVLSLSQAL 680
                P    S      R  G    PR + P + + +G            RE +L   Q  
Sbjct: 1458 PPLLPAPLASCPPPMKRKPG---RPRRSPPSMLSLDGPLVRPPAGAALGRELLLLPGQPQ 1514

Query: 681  ATEASQWHRMMTGG-NLDSQGDPLPGVPLPPSDPTRQETPPPRSPPV 726
                   H   T   +  + G P P  PLPP  P     PPP  PPV
Sbjct: 1515 TPVFPSTHDPRTVTLDFRNAGIPAPPPPLPPQPP-----PPPPPPPV 1556



 Score = 33.1 bits (74), Expect = 1.0
 Identities = 35/140 (25%), Positives = 50/140 (35%), Gaps = 8/140 (5%)

Query: 226 RARSPDLFTPLSRPPSPLSLPRPRSAPARRP-PAPSGDTAPPARPHTPLSRIDVRPPLDW 284
           +A+  D  T    PP   + P P    A  P   P     PP    T  +    R   D 
Sbjct: 369 KAQPQDSATFAHTPPPAQATPAPGFKSAFSPYQTPVAHFPPPPEEPTATAAFGAR---DS 425

Query: 285 GPQRQTLSRPPTPRRGPPSEAGGGKPPRSPQHWSQEPRTQAHSGSPTYLQLPPRPPGTRA 344
           G  R+  + PP P   P ++   G PP  P     +  +    G PT+    P P  +  
Sbjct: 426 GEFRRAPAPPPLPPAEPLAKEKPGTPPGPP---PPDTNSMELGGRPTF-GWSPEPCDSPG 481

Query: 345 SMVLLPGPPLESTFHQSLET 364
           +  L   P      H SL++
Sbjct: 482 TPTLESSPAGPEKPHDSLDS 501



 Score = 32.7 bits (73), Expect = 1.3
 Identities = 32/127 (25%), Positives = 44/127 (34%), Gaps = 14/127 (11%)

Query: 239 PPSPLSLPRPRSAPARRPPAPSGDTAPPARPHTPLSRIDVRPPLDWGPQRQTLSRPPTPR 298
           P +P++     SA   +P   +   A  A P      + + PP  + P       PP P 
Sbjct: 647 PSAPIT-----SADCPKPMVVTPGAAAVAAPSVLAPTLPLPPPPGFPPL------PPPPP 695

Query: 299 RGPPSEAGGGKPPRSPQHWSQEPRTQAHSGSPTYLQLPPRPPGTRASMVLLPGPPLESTF 358
             PP       PP  P      P   A +  P  L   P PPG     +L P PP     
Sbjct: 696 PPPPQPGFPMPPPLPPPPPPPPPAHPAVTVPPPPL---PAPPGVPPPPILPPLPPFPPGL 752

Query: 359 HQSLETD 365
              ++ D
Sbjct: 753 FPVMQVD 759



 Score = 31.6 bits (70), Expect = 3.0
 Identities = 22/61 (36%), Positives = 25/61 (40%), Gaps = 16/61 (26%)

Query: 702 PLPGVPLPPSDPTRQETPPPRSPPVANSGSTGFSRRGSGRGGGPTPWGPAWDAGIAPPVL 761
           P PG P+PP  P     PPP  PP A+   T            P P  PA      PP+L
Sbjct: 699 PQPGFPMPPPLP-----PPPPPPPPAHPAVT-----------VPPPPLPAPPGVPPPPIL 742

Query: 762 P 762
           P
Sbjct: 743 P 743



 Score = 31.2 bits (69), Expect = 3.9
 Identities = 23/63 (36%), Positives = 29/63 (46%), Gaps = 6/63 (9%)

Query: 707 PLPPSDPTRQE---TPPPRSPPVANSGSTGFSRRGSGRGGGP--TPWGPAWDAGIAPPVL 761
           PLPP++P  +E   TPP   PP  NS   G  R   G    P  +P  P  ++  A P  
Sbjct: 436 PLPPAEPLAKEKPGTPPGPPPPDTNSMELG-GRPTFGWSPEPCDSPGTPTLESSPAGPEK 494

Query: 762 PQD 764
           P D
Sbjct: 495 PHD 497


>gi|157785645 SPEG complex locus [Homo sapiens]
          Length = 3267

 Score = 54.3 bits (129), Expect = 4e-07
 Identities = 106/439 (24%), Positives = 147/439 (33%), Gaps = 110/439 (25%)

Query: 213 SPTTDLH-SGLQMRRARSPDLFTPLSRPPSPLSLPRPRSAPARRPPAPSGDTAPPARPHT 271
           S  +DL+ S   + R R+  L   +S P S L    P   P     AP     PP     
Sbjct: 250 SVASDLYGSAFSLYRGRA--LSIHVSVPQSGLRREEPDLQPQLASEAPRRPAQPP----- 302

Query: 272 PLSRIDVRPPLDWGPQRQTLSRPPTPR---RGPPS-EAGGGKPPRSPQHWSQEP-----R 322
                         P +  L  PP+PR   R PP   A     P SP   +QEP      
Sbjct: 303 --------------PSKSALLPPPSPRVGKRSPPGPPAQPAATPTSPHRRTQEPVLPEDT 348

Query: 323 TQAHSGSPTYLQLPPRPPGTRASMVLLPGPPLESTFHQSLETDTLLTKLCGQDRLLR--- 379
           T             P   GT  S    P  PL        E    L+ L    RL+R   
Sbjct: 349 TTEEKRGKKSKSSGPSLAGTAESR---PQTPLS-------EASGRLSALGRSPRLVRAGS 398

Query: 380 RLQEEIDQKQEEKEQLE------------------AALELTRQQL-------GQATREAG 414
           R+ +++   +E +  LE                   +LE  + +        G +  E  
Sbjct: 399 RILDKLQFFEERRRSLERSDSPPAPLRPWVPLRKARSLEQPKSERGAPWGTPGASQEELR 458

Query: 415 APGRAWGRQRLLQDRLVSVRATLCHLTQERERVWDTYSGLEQELGTLRETLEYLLHLGSP 474
           APG    R+RL Q +     A+L   T++R    D      QELG +R +        S 
Sbjct: 459 APGSVAERRRLFQQK----AASLDERTRQRSPASDLELRFAQELGRIRRST-------SR 507

Query: 475 QDRVSAQQQLWMVEDTLAGLGGPQKPPPHTEPDSPSPVLQGEESSERESLPESLELSSPR 534
           ++ V + + L            P +PP  + P +P         + R   P + +  SP 
Sbjct: 508 EELVRSHESLRATLQRAPSPREPGEPPLFSRPSTP--------KTSRAVSPAAAQPPSPS 559

Query: 535 SPETDWGRPPGGDKDLASPHLGLGSPRVSRASSPEGRHLPSPQLGTKAPVARPRMSAQEQ 594
           S E      PG +            P   R+  P GR  P      + P    R   Q  
Sbjct: 560 SAE-----KPGDE------------PGRPRSRGPAGRTEPG-----EGPQQEVRRRDQFP 597

Query: 595 LERMRRNQECGRPFPRPTS 613
           L R R  QEC  P P P +
Sbjct: 598 LTRSRAIQECRSPVPPPAA 616



 Score = 49.3 bits (116), Expect = 1e-05
 Identities = 80/326 (24%), Positives = 114/326 (34%), Gaps = 63/326 (19%)

Query: 4   SRPRSSLSLASSASTISSLSSLSPKKPTRAVNKIHAFGKRGNALRRDPNLPVHIRGWLHK 63
           SRP++ LS AS   +    S    +  +R ++K+  F +R  +L R  + P  +R W+  
Sbjct: 371 SRPQTPLSEASGRLSALGRSPRLVRAGSRILDKLQFFEERRRSLERSDSPPAPLRPWVPL 430

Query: 64  QDSSGLRLWKRRWFVLSGHCLFYYKDSREESVLGSVLLPSYNIRPDGPGAPRGRRFTFTA 123
           + +  L   K                S   +  G+       +R  G  A R R F   A
Sbjct: 431 RKARSLEQPK----------------SERGAPWGTPGASQEELRAPGSVAERRRLFQQKA 474

Query: 124 EHPGMRTYVLAADTLEDLRGWLRALGRASRAEGDDY---GQPRSPARPQPGEGPGGPGGP 180
                RT   +  +  +LR + + LGR  R+   +          A  Q    P  PG P
Sbjct: 475 ASLDERTRQRSPASDLELR-FAQELGRIRRSTSREELVRSHESLRATLQRAPSPREPGEP 533

Query: 181 PEVSRGEEGRISESPEVTRLSRGRGRPRLLTPSPTTDLHSGLQMRRARSPDLFTPLSRPP 240
           P  SR                            P+T   S     RA SP      ++PP
Sbjct: 534 PLFSR----------------------------PSTPKTS-----RAVSP----AAAQPP 556

Query: 241 SPLSLPRPRSAPAR-RPPAPSGDTAPPARPHTPLSRIDVRPPLDWGPQRQTLSRPPTPRR 299
           SP S  +P   P R R   P+G T P   P   + R D  P       ++  S  P P  
Sbjct: 557 SPSSAEKPGDEPGRPRSRGPAGRTEPGEGPQQEVRRRDQFPLTRSRAIQECRSPVPPPAA 616

Query: 300 GPPSEAGGGKPPRSPQHWSQEPRTQA 325
            PP       P R      +EP  QA
Sbjct: 617 DPPEARTKAPPGR-----KREPPAQA 637



 Score = 46.6 bits (109), Expect = 9e-05
 Identities = 90/342 (26%), Positives = 124/342 (36%), Gaps = 81/342 (23%)

Query: 133  LAADTLEDLRGWLR--ALGRASRAEGDDYGQP--------RSPARPQPGEGPGG----PG 178
            L    LE L G  R   + RA+ +E   + QP        +S +  Q    P G     G
Sbjct: 2087 LRGPLLESLGGRARDPRMARAASSEAAPHHQPPLENRGLQKSSSFSQGEAEPRGRHRRAG 2146

Query: 179  GPPEVSRGEEG--RISESPEVTRLSRGRGRPRLLTPSPTTDLHSGLQMRRARSPDLFTPL 236
             P E+     G  R+ ESP ++ LS  +       PS            R  +P   TP 
Sbjct: 2147 APLEIPVARLGARRLQESPSLSALSEAQ-------PSSPA---------RPSAPKPSTPK 2190

Query: 237  SRPPSPLSLPRPRSAPARRPPAPSGDTAPPARPHTPLSRIDVRPPLDWGPQR-QTLSRPP 295
            S  PS  +   P  AP    P P+ D AP  RP  P+      PP    PQ  QTL+ P 
Sbjct: 2191 SAEPSATT---PSDAPQPPAPQPAQDKAPEPRPE-PVRASKPAPP----PQALQTLALPL 2242

Query: 296  T-----------------PRRGPPSEAGGGKP-------PRSPQHWSQEPRTQAHSGSPT 331
            T                 P +GP +     KP         SP   + E R  +  G P 
Sbjct: 2243 TPYAQIIQSLQLSGHAQGPSQGPAAPPSEPKPHAAVFARVASPPPGAPEKRVPSAGGPPV 2302

Query: 332  YLQ------LPPRPPGTRASMV--LLPGPPLESTFHQSLETD-----TLLTKLCGQDRLL 378
              +      +PPRP  + +S +  L      E+ F +S E+       LL++   ++R  
Sbjct: 2303 LAEKARVPTVPPRPGSSLSSSIENLESEAVFEAKFKRSRESPLSLGLRLLSRSRSEERGP 2362

Query: 379  RRLQEEID---QKQEEKEQLEAALELTRQQLGQATREAGAPG 417
             R  EE D   +       LE      R +  Q  R  G PG
Sbjct: 2363 FRGAEEEDGIYRPSPAGTPLELVRRPERSRSVQDLRAVGEPG 2404



 Score = 42.4 bits (98), Expect = 0.002
 Identities = 76/301 (25%), Positives = 100/301 (33%), Gaps = 77/301 (25%)

Query: 497  PQKPPPHTEPDSPSPVLQGEESSERESLPESLELSSPRSPETDWGRP-----PGGDKDLA 551
            P++PPP       S  L     SE E L E   +  P  PE    R      P  D+ L 
Sbjct: 1909 PRRPPP-------SGGLSSSSDSEEEELEELPSVPRPLQPEFSGSRVSLTDIPTEDEALG 1961

Query: 552  SPHLGLGSP----RVSRASSPEGRHLPSPQLGTKAPVARPRMSAQEQLERMRRNQECGRP 607
            +P  G  +P       RA S + +  PSP+    +P   P   A  +   +RR       
Sbjct: 1962 TPETGAATPMDWQEQGRAPSQD-QEAPSPE-ALPSPGQEPAAGASPRRGELRRGSSAESA 2019

Query: 608  FPRPTSPRLLTLGRTLS-------PARRQPDV-EQRPVVGHSGA-----------QKWLR 648
             PR   PR   LGR L        P RR P     R   G  G            Q+ LR
Sbjct: 2020 LPR-AGPR--ELGRGLHKAASVELPQRRSPSPGATRLARGGLGEGEYAQRLQALRQRLLR 2076

Query: 649  SSGSWSSPRNTTPYLPTSEGHRERVLSLSQALATEASQWH------RMMTGGNLDSQGDP 702
                          L  S G R R   +++A ++EA+  H      R +   +  SQG+ 
Sbjct: 2077 GGPEDGKVSGLRGPLLESLGGRARDPRMARAASSEAAPHHQPPLENRGLQKSSSFSQGEA 2136

Query: 703  LP-------GVPLP------------------------PSDPTRQETPPPRSPPVANSGS 731
             P       G PL                         PS P R   P P +P  A   +
Sbjct: 2137 EPRGRHRRAGAPLEIPVARLGARRLQESPSLSALSEAQPSSPARPSAPKPSTPKSAEPSA 2196

Query: 732  T 732
            T
Sbjct: 2197 T 2197



 Score = 39.7 bits (91), Expect = 0.011
 Identities = 61/263 (23%), Positives = 82/263 (31%), Gaps = 67/263 (25%)

Query: 153  RAEGDDYGQPRSPARPQPGEGPGGPG--------------------GPPEVSRGEEG--- 189
            RA   D   P   A P PG+ P                        GP E+ RG      
Sbjct: 1978 RAPSQDQEAPSPEALPSPGQEPAAGASPRRGELRRGSSAESALPRAGPRELGRGLHKAAS 2037

Query: 190  -----RISESPEVTRLSRG------------RGRPRLLTPSPTTDLHSGLQ-------MR 225
                 R S SP  TRL+RG              R RLL   P     SGL+         
Sbjct: 2038 VELPQRRSPSPGATRLARGGLGEGEYAQRLQALRQRLLRGGPEDGKVSGLRGPLLESLGG 2097

Query: 226  RARSPDLFTPLSRPPSPLSLPRPRSAPARRPPAPSGDTAPPARPH--------TPLSRID 277
            RAR P +    S   +P   P   +   ++  + S   A P   H         P++R+ 
Sbjct: 2098 RARDPRMARAASSEAAPHHQPPLENRGLQKSSSFSQGEAEPRGRHRRAGAPLEIPVARLG 2157

Query: 278  VR-----PPLD-------WGPQRQTLSRPPTPRRGPPSEAGGGKPPRSPQHWSQEPRTQA 325
             R     P L          P R +  +P TP+   PS       P+ P     + +   
Sbjct: 2158 ARRLQESPSLSALSEAQPSSPARPSAPKPSTPKSAEPSATTPSDAPQPPAPQPAQDKAPE 2217

Query: 326  HSGSPTYLQLPPRPPGTRASMVL 348
                P     P  PP    ++ L
Sbjct: 2218 PRPEPVRASKPAPPPQALQTLAL 2240



 Score = 34.3 bits (77), Expect = 0.46
 Identities = 28/97 (28%), Positives = 37/97 (38%), Gaps = 1/97 (1%)

Query: 162 PRSPARPQPGEGPGGPGGPPEVSRGEEGRISESPEVTRLSRGRGRPRLLTPSPTTDLHSG 221
           PR PA+P P +    P   P V +         P  T  S  R     + P  TT     
Sbjct: 295 PRRPAQPPPSKSALLPPPSPRVGKRSPPGPPAQPAATPTSPHRRTQEPVLPEDTTTEEKR 354

Query: 222 LQMRRARSPDLF-TPLSRPPSPLSLPRPRSAPARRPP 257
            +  ++  P L  T  SRP +PLS    R +   R P
Sbjct: 355 GKKSKSSGPSLAGTAESRPQTPLSEASGRLSALGRSP 391



 Score = 33.5 bits (75), Expect = 0.78
 Identities = 76/285 (26%), Positives = 98/285 (34%), Gaps = 50/285 (17%)

Query: 493 GLGGPQKPP--PHTEPDSP-----SPVLQGEESSERESLPESLELSSPRSPETDWGRPPG 545
           G   P  PP  P   P SP      PVL  E+++  E   +  + S P    T   RP  
Sbjct: 317 GKRSPPGPPAQPAATPTSPHRRTQEPVLP-EDTTTEEKRGKKSKSSGPSLAGTAESRPQT 375

Query: 546 GDKDLASPHLGLG-SPRVSRASSPEGRHLPSPQLGTKAPVARPRMSAQEQLERMRRNQEC 604
              + +     LG SPR+ RA S   R L   Q                  E  RR+ E 
Sbjct: 376 PLSEASGRLSALGRSPRLVRAGS---RILDKLQF----------------FEERRRSLER 416

Query: 605 GRPFPRPTSPRL-LTLGRTLSPARRQPDVEQRPVVGHSGA-QKWLRSSGSWSSPRNTTPY 662
               P P  P + L   R+L     QP  E+    G  GA Q+ LR+ GS +  R     
Sbjct: 417 SDSPPAPLRPWVPLRKARSLE----QPKSERGAPWGTPGASQEELRAPGSVAERRRLFQQ 472

Query: 663 LPTSEGHRERVLS----LSQALATEASQWHRMMTGGNLDSQGDPL------------PGV 706
              S   R R  S    L    A E  +  R  +   L    + L            PG 
Sbjct: 473 KAASLDERTRQRSPASDLELRFAQELGRIRRSTSREELVRSHESLRATLQRAPSPREPGE 532

Query: 707 PLPPSDPTRQETPPPRSPPVANSGSTGFSRRGSGRGGGPTPWGPA 751
           P   S P+  +T    SP  A   S   + +     G P   GPA
Sbjct: 533 PPLFSRPSTPKTSRAVSPAAAQPPSPSSAEKPGDEPGRPRSRGPA 577


>gi|209571537 proline-rich protein BstNI subfamily 2 [Homo sapiens]
          Length = 416

 Score = 54.3 bits (129), Expect = 4e-07
 Identities = 62/220 (28%), Positives = 83/220 (37%), Gaps = 36/220 (16%)

Query: 155 EGDDYGQPRS-PARPQ--PGEGPGGPGGPPEVSRGEEGRISESPEVTRLSRGRGRPRLLT 211
           +GD    PRS P +PQ  P +G   P GPP      +G   +     +     G+P+   
Sbjct: 104 QGDKSRSPRSPPGKPQGPPPQGGNQPQGPPPPPGKPQGPPPQGGNKPQGPPPPGKPQ--G 161

Query: 212 PSPTTDLHSGLQMRRARSPDLFTPLSRPPSPLSLPRPRSAPARRP--PAPSGDTAP--PA 267
           P P  D  S    R +RSP    P   PP   + P+    P  +P  P P G   P  P 
Sbjct: 162 PPPQGDNKS----RSSRSPP-GKPQGPPPQGGNQPQGPPPPPGKPQGPPPQGGNKPQGPP 216

Query: 268 RPHTPLSRIDVRPPLDWGPQRQTLSRPPTPRRGPPSEAGG---------GKPPRSPQHWS 318
            P  P       PP     + Q+   PP   +GPP + G          GKP   P    
Sbjct: 217 PPGKPQG-----PPPQGDNKSQSARSPPGKPQGPPPQGGNQPQGPPPPPGKPQGPPPQGG 271

Query: 319 QEPRTQAHSGSPTYLQLPPRPPGTRASMVLLP-----GPP 353
            +P+     G P   Q PP   G+++     P     GPP
Sbjct: 272 NKPQGPPPPGKP---QGPPPQGGSKSRSSRSPPGKPQGPP 308



 Score = 53.5 bits (127), Expect = 7e-07
 Identities = 63/217 (29%), Positives = 82/217 (37%), Gaps = 39/217 (17%)

Query: 149 GRASRAEGDDYGQPRSPARPQPGEGPGGPGGPPEVSRGEEGRISESPEVTRLSRGRGRPR 208
           G  SR+     G+P+ P  PQ G  P GP  PP   +G   +    P+        G+P+
Sbjct: 105 GDKSRSPRSPPGKPQGPP-PQGGNQPQGPPPPPGKPQGPPPQGGNKPQGPPPP---GKPQ 160

Query: 209 LLTPSPTTDLHSGLQMRRARSPDLFTPLSRPPSPLSLPRPRSAPARRP--PAPSGDTAP- 265
              P P  D  S    R +RSP    P   PP   + P+    P  +P  P P G   P 
Sbjct: 161 --GPPPQGDNKS----RSSRSPP-GKPQGPPPQGGNQPQGPPPPPGKPQGPPPQGGNKPQ 213

Query: 266 ----PARPHTPLSRIDVR-------------PPLDWGPQRQTLSRPPTPRRGPPSEAG-- 306
               P +P  P  + D +             PP   G Q Q    PP   +GPP + G  
Sbjct: 214 GPPPPGKPQGPPPQGDNKSQSARSPPGKPQGPPPQGGNQPQGPPPPPGKPQGPPPQGGNK 273

Query: 307 --GGKPPRSPQHWSQEPRTQAHSGSPTYLQLPPRPPG 341
             G  PP  P    Q P  Q  S S +    P +P G
Sbjct: 274 PQGPPPPGKP----QGPPPQGGSKSRSSRSPPGKPQG 306



 Score = 53.1 bits (126), Expect = 9e-07
 Identities = 52/183 (28%), Positives = 70/183 (38%), Gaps = 18/183 (9%)

Query: 160 GQPRSPARPQPGEGPGGPGGPPEVSRGEEGRISESPEVTRLSRGRGRPRLLTPSPTTDLH 219
           G+P+ P  PQ G  P GP  PP   +G   +    P+        G+P+   P P     
Sbjct: 240 GKPQGPP-PQGGNQPQGPPPPPGKPQGPPPQGGNKPQGPPPP---GKPQ--GPPP----Q 289

Query: 220 SGLQMRRARSPDLFTPLSRPPSPLSLPRPRSAPARRP--PAPSGDTAPPARPHTPLSRID 277
            G + R +RSP    P   PP   + P+    P  +P  P P G   P   P  P  +  
Sbjct: 290 GGSKSRSSRSPP-GKPQGPPPQGGNQPQGPPPPPGKPQGPPPQGGNKPQGPP--PPGKPQ 346

Query: 278 VRPPLDWGPQRQTLSRPPTPRRGPPSEAGGGKPPRSPQHWSQEPRTQAHSGSPTYLQLPP 337
             PP      R   S P  P+  P  E    + P  P   + +      +G P   Q PP
Sbjct: 347 GPPPQGGSKSRSARSPPGKPQGPPQQEGNNPQGPPPPAGGNPQQPQAPPAGQP---QGPP 403

Query: 338 RPP 340
           RPP
Sbjct: 404 RPP 406



 Score = 51.2 bits (121), Expect = 4e-06
 Identities = 67/270 (24%), Positives = 88/270 (32%), Gaps = 44/270 (16%)

Query: 497 PQKPPPHTEPDSPSPVLQGEESSERESLPESLELSSPRSPETDWGRPPGGDKDLASPHLG 556
           PQ PPP  +P  P P  QG++S    S P   +   P+      G PP   K    P  G
Sbjct: 89  PQGPPPPGKPQGPPP--QGDKSRSPRSPPGKPQGPPPQGGNQPQGPPPPPGKPQGPPPQG 146

Query: 557 LGSPR-VSRASSPEGRHLPSPQLGTKAPVARPRMSAQEQLERMRRNQECGRPFPRPTSPR 615
              P+       P+G   P PQ   K+  +R      +       NQ  G P P P  P+
Sbjct: 147 GNKPQGPPPPGKPQG---PPPQGDNKSRSSRSPPGKPQGPPPQGGNQPQGPP-PPPGKPQ 202

Query: 616 LLTLGRTLSPARRQPDVEQRPVVGHSGAQKWLRSSGSWSSPRNTTPYLPTSEGHRERVLS 675
                    P  +  +  Q P                   P    P  P  +G  +    
Sbjct: 203 --------GPPPQGGNKPQGP-------------------PPPGKPQGPPPQGDNKS--- 232

Query: 676 LSQALATEASQWHRMMTGGNLDSQGDPLPGVPL--PPSDPTRQETPP----PRSPPVANS 729
              A +           GGN      P PG P   PP    + + PP    P+ PP    
Sbjct: 233 -QSARSPPGKPQGPPPQGGNQPQGPPPPPGKPQGPPPQGGNKPQGPPPPGKPQGPPPQGG 291

Query: 730 GSTGFSRRGSGRGGGPTPWGPAWDAGIAPP 759
             +  SR   G+  GP P G     G  PP
Sbjct: 292 SKSRSSRSPPGKPQGPPPQGGNQPQGPPPP 321



 Score = 50.1 bits (118), Expect = 8e-06
 Identities = 61/214 (28%), Positives = 80/214 (37%), Gaps = 39/214 (18%)

Query: 152 SRAEGDDYGQPRSPARPQPGEGPGGPGGPPEVSRGEEGRISESPEVTRLSRGRGRPRLLT 211
           SR+     G+P+ P  PQ G  P GP  PP   +G   +    P+        G+P+   
Sbjct: 170 SRSSRSPPGKPQGPP-PQGGNQPQGPPPPPGKPQGPPPQGGNKPQGPPPP---GKPQ--G 223

Query: 212 PSPTTDLHSGLQMRRARSPDLFTPLSRPPSPLSLPRPRSAPARRP--PAPSGDTAP---- 265
           P P  D  S    + ARSP    P   PP   + P+    P  +P  P P G   P    
Sbjct: 224 PPPQGDNKS----QSARSPP-GKPQGPPPQGGNQPQGPPPPPGKPQGPPPQGGNKPQGPP 278

Query: 266 -PARPHTPLSRIDVR-------------PPLDWGPQRQTLSRPPTPRRGPPSEAG----G 307
            P +P  P  +   +             PP   G Q Q    PP   +GPP + G    G
Sbjct: 279 PPGKPQGPPPQGGSKSRSSRSPPGKPQGPPPQGGNQPQGPPPPPGKPQGPPPQGGNKPQG 338

Query: 308 GKPPRSPQHWSQEPRTQAHSGSPTYLQLPPRPPG 341
             PP  P    Q P  Q  S S +    P +P G
Sbjct: 339 PPPPGKP----QGPPPQGGSKSRSARSPPGKPQG 368



 Score = 49.7 bits (117), Expect = 1e-05
 Identities = 46/164 (28%), Positives = 61/164 (37%), Gaps = 16/164 (9%)

Query: 160 GQPRSPA-----RPQPGEGPGGPGGPPEVSRGEEGRISESPEVTRLS---RGRGRPRLLT 211
           G+P+ P      +PQ    PG P GPP    G + R S SP         +G  +P+   
Sbjct: 261 GKPQGPPPQGGNKPQGPPPPGKPQGPPPQG-GSKSRSSRSPPGKPQGPPPQGGNQPQ--G 317

Query: 212 PSPTTDLHSGLQMRRARSPDLFTPLSRPPSPLSLPRPRSAPARRPPAPSGDTAPPARPHT 271
           P P      G   +    P    P  +P  P      +S  AR PP       P   P  
Sbjct: 318 PPPPPGKPQGPPPQGGNKPQGPPPPGKPQGPPPQGGSKSRSARSPPGK-----PQGPPQQ 372

Query: 272 PLSRIDVRPPLDWGPQRQTLSRPPTPRRGPPSEAGGGKPPRSPQ 315
             +     PP   G  +Q  + P    +GPP    GG+P R PQ
Sbjct: 373 EGNNPQGPPPPAGGNPQQPQAPPAGQPQGPPRPPQGGRPSRPPQ 416



 Score = 46.6 bits (109), Expect = 9e-05
 Identities = 58/217 (26%), Positives = 77/217 (35%), Gaps = 41/217 (18%)

Query: 160 GQPRSPARPQPGEGPGGPGGPPEVSRGEEGRISESPEVTRLSRGR---------GRPRLL 210
           G P+  A PQ G  P GP  PP   +G   +    P+      G+          +P+  
Sbjct: 34  GNPQG-APPQGGNKPQGPPSPPGKPQGPPPQGGNQPQGPPPPPGKPQGPPPQGGNKPQGP 92

Query: 211 TP--SPTTDLHSGLQMRRARSPDLFTPLSRPPSPLSLPRPRSAPARRP--PAPSGDT--- 263
            P   P      G + R  RSP    P   PP   + P+    P  +P  P P G     
Sbjct: 93  PPPGKPQGPPPQGDKSRSPRSPP-GKPQGPPPQGGNQPQGPPPPPGKPQGPPPQGGNKPQ 151

Query: 264 --APPARPHTPLSRIDVR-------------PPLDWGPQRQTLSRPPTPRRGPPSEAG-- 306
              PP +P  P  + D +             PP   G Q Q    PP   +GPP + G  
Sbjct: 152 GPPPPGKPQGPPPQGDNKSRSSRSPPGKPQGPPPQGGNQPQGPPPPPGKPQGPPPQGGNK 211

Query: 307 --GGKPPRSPQHWSQEPRTQAHSGSPTYLQLPPRPPG 341
             G  PP  P    Q P  Q  + S +    P +P G
Sbjct: 212 PQGPPPPGKP----QGPPPQGDNKSQSARSPPGKPQG 244



 Score = 43.5 bits (101), Expect = 8e-04
 Identities = 69/278 (24%), Positives = 83/278 (29%), Gaps = 44/278 (15%)

Query: 497 PQKPPPHTEPDSPSPVLQGEESSERESLPESLELSSPRSPETDWGRPPGGDKDLASPHLG 556
           PQ PPP  +P  P P    +  S R S P   +   P+      G PP   K    P  G
Sbjct: 150 PQGPPPPGKPQGPPPQGDNKSRSSR-SPPGKPQGPPPQGGNQPQGPPPPPGKPQGPPPQG 208

Query: 557 LGSPR-VSRASSPEGRHLPSPQLGTKAPVARPRMSAQEQLERMRRNQECGRPFP--RPTS 613
              P+       P+G   P PQ   K+  AR      +       NQ  G P P  +P  
Sbjct: 209 GNKPQGPPPPGKPQG---PPPQGDNKSQSARSPPGKPQGPPPQGGNQPQGPPPPPGKPQG 265

Query: 614 PRLLTLGRTLSPARRQPDVEQRPVVGHSGAQKWLRSSGSWSSPRNTTPYLPTSEGHRERV 673
           P      +   P    P   Q P     G  K   S      P+   P            
Sbjct: 266 PPPQGGNKPQGPP--PPGKPQGPPP--QGGSKSRSSRSPPGKPQGPPPQ----------- 310

Query: 674 LSLSQALATEASQWHRMMTGGNLDSQGDPLPGVPL--PPSDPTRQETPPPRSPPVANSGS 731
                              GGN      P PG P   PP    + + PPP   P      
Sbjct: 311 -------------------GGNQPQGPPPPPGKPQGPPPQGGNKPQGPPPPGKPQGPPPQ 351

Query: 732 TGFSRRGSGRGGGPTPWGPAWDAGIAPPVLPQDEGAWP 769
            G S+  S R     P GP    G  P   P   G  P
Sbjct: 352 GG-SKSRSARSPPGKPQGPPQQEGNNPQGPPPPAGGNP 388



 Score = 42.7 bits (99), Expect = 0.001
 Identities = 40/144 (27%), Positives = 54/144 (37%), Gaps = 10/144 (6%)

Query: 497 PQKPPPHTEPDSPSPVLQGEESSERESLPESLELSSPRSPETDWGRPPGGDKDLASPHLG 556
           PQ PPP  +P  P P   G +S    S P   +   P+      G PP   K    P  G
Sbjct: 274 PQGPPPPGKPQGPPP-QGGSKSRSSRSPPGKPQGPPPQGGNQPQGPPPPPGKPQGPPPQG 332

Query: 557 LGSPR-VSRASSPEGRHLPSPQLGTKAPVARPRMSAQEQLERMRRNQECGRPFPRPTSPR 615
              P+       P+G   P PQ G+K+  AR      +   +   N   G P P   +P+
Sbjct: 333 GNKPQGPPPPGKPQG---PPPQGGSKSRSARSPPGKPQGPPQQEGNNPQGPPPPAGGNPQ 389

Query: 616 LLTLGRTLSPARRQPDVEQRPVVG 639
                +  +P   QP    RP  G
Sbjct: 390 -----QPQAPPAGQPQGPPRPPQG 408



 Score = 42.0 bits (97), Expect = 0.002
 Identities = 34/119 (28%), Positives = 47/119 (39%), Gaps = 17/119 (14%)

Query: 236 LSRPPSP-LSLPRPRSAPARRPPAPSGDTAPPARPHTPLSRIDVRP------------PL 282
           +S+  SP L    P+ AP +    P G  +PP +P  P  +   +P            P 
Sbjct: 23  VSQEESPSLIAGNPQGAPPQGGNKPQGPPSPPGKPQGPPPQGGNQPQGPPPPPGKPQGPP 82

Query: 283 DWGPQRQTLSRPPTPRRGPPSEAGGGKPPRSPQHWSQEPRTQAHSGSPTYLQLPPRPPG 341
             G  +     PP   +GPP +    + PRSP    Q P  Q  +      Q PP PPG
Sbjct: 83  PQGGNKPQGPPPPGKPQGPPPQGDKSRSPRSPPGKPQGPPPQGGNQP----QGPPPPPG 137



 Score = 32.0 bits (71), Expect = 2.3
 Identities = 24/73 (32%), Positives = 28/73 (38%), Gaps = 7/73 (9%)

Query: 693 GGNLDSQGDPLPGVPL--PPSDPTRQETPP----PRSPPVANSGSTGFSRRGSGRGGGPT 746
           GGN      P PG P   PP    + + PP    P+ PP     S    R   G+  GP 
Sbjct: 64  GGNQPQGPPPPPGKPQGPPPQGGNKPQGPPPPGKPQGPPPQGDKSRS-PRSPPGKPQGPP 122

Query: 747 PWGPAWDAGIAPP 759
           P G     G  PP
Sbjct: 123 PQGGNQPQGPPPP 135


>gi|41349484 proline-rich protein BstNI subfamily 1 isoform 2
           preproprotein [Homo sapiens]
          Length = 198

 Score = 54.3 bits (129), Expect = 4e-07
 Identities = 54/188 (28%), Positives = 76/188 (40%), Gaps = 40/188 (21%)

Query: 160 GQPRSPARPQPGEGPGGPGGPPEVSRGEEGRISESPEVTRLSRGRGRPRLLTPSPTTDLH 219
           G P+ P+ PQ G  P GP  PP   +G   +    P+        G+P+   P P  D  
Sbjct: 34  GNPQGPS-PQGGNKPQGPPPPPGKPQGPPPQGGNKPQGPPPP---GKPQ--GPPPQGD-- 85

Query: 220 SGLQMRRARSPDLFTPLSRPPSPLSLPRPRSAPARRPPAPSGDTA----PPARPHTPLSR 275
                 ++RSP        PP     P P+    + PP   G+      PP +P  P   
Sbjct: 86  ------KSRSP------RSPPGKPQGPPPQGGKPQGPPPQGGNKPQGPPPPGKPQGP--- 130

Query: 276 IDVRPPLDWGPQRQTLSRPPTPRRGPPSEAGG---GKPPRSPQHWSQEPRTQAHSGSPTY 332
                P   G + Q+   PP   +GPP + G    G PP +  +  Q+P+    +G P  
Sbjct: 131 -----PAQGGSKSQSARSPPGKPQGPPQQEGNNPQGPPPPAGGN-PQQPQAPP-AGQP-- 181

Query: 333 LQLPPRPP 340
            Q PPRPP
Sbjct: 182 -QGPPRPP 188



 Score = 51.6 bits (122), Expect = 3e-06
 Identities = 45/161 (27%), Positives = 62/161 (38%), Gaps = 22/161 (13%)

Query: 160 GQPRSPA-----RPQPGEGPGGPGGPPEVSRGEEGRISESPEVTRLSRGRGRPRLLTPSP 214
           G+P+ P      +PQ    PG P GPP   +G++ R   SP         G+P+   P P
Sbjct: 55  GKPQGPPPQGGNKPQGPPPPGKPQGPPP--QGDKSRSPRSPP--------GKPQ--GPPP 102

Query: 215 TTDLHSGLQMRRARSPDLFTPLSRPPSPLSLPRPRSAPARRPPAPSGDTAPPARPHTPLS 274
                 G   +    P    P  +P  P +    +S  AR PP       P   P    +
Sbjct: 103 QGGKPQGPPPQGGNKPQGPPPPGKPQGPPAQGGSKSQSARSPPGK-----PQGPPQQEGN 157

Query: 275 RIDVRPPLDWGPQRQTLSRPPTPRRGPPSEAGGGKPPRSPQ 315
                PP   G  +Q  + P    +GPP    GG+P R PQ
Sbjct: 158 NPQGPPPPAGGNPQQPQAPPAGQPQGPPRPPQGGRPSRPPQ 198



 Score = 42.0 bits (97), Expect = 0.002
 Identities = 39/143 (27%), Positives = 55/143 (38%), Gaps = 20/143 (13%)

Query: 497 PQKPPPHTEPDSPSPVLQGEESSERESLPESLELSSPRSPETDWGRPPGGDKDLASPHLG 556
           PQ PPP  +P  P P  QG++S    S P   +   P+  +     P GG+K    P  G
Sbjct: 68  PQGPPPPGKPQGPPP--QGDKSRSPRSPPGKPQGPPPQGGKPQGPPPQGGNKPQGPPPPG 125

Query: 557 LGSPRVSRASSPEGRHLPSPQLGTKAPVARPRMSAQEQLERMRRNQECGRPFPRPTSPRL 616
                      P+G   P  Q G+K+  AR      +   +   N   G P P   +P+ 
Sbjct: 126 ----------KPQG---PPAQGGSKSQSARSPPGKPQGPPQQEGNNPQGPPPPAGGNPQ- 171

Query: 617 LTLGRTLSPARRQPDVEQRPVVG 639
               +  +P   QP    RP  G
Sbjct: 172 ----QPQAPPAGQPQGPPRPPQG 190



 Score = 30.0 bits (66), Expect = 8.6
 Identities = 23/67 (34%), Positives = 27/67 (40%), Gaps = 3/67 (4%)

Query: 693 GGNLDSQGDPLPGVPLPPSDPTRQETPPPRSPPVANSGSTGFSRRGSGRGGGPTPWGPAW 752
           GGN   QG P PG P  P      ++   RSPP    G     + G+   G P P G   
Sbjct: 114 GGN-KPQGPPPPGKPQGPPAQGGSKSQSARSPPGKPQGPP--QQEGNNPQGPPPPAGGNP 170

Query: 753 DAGIAPP 759
               APP
Sbjct: 171 QQPQAPP 177


  Database: hs.faa
    Posted date:  Aug 4, 2009  4:42 PM
  Number of letters in database: 18,247,518
  Number of sequences in database:  37,866
  
Lambda     K      H
   0.313    0.133    0.412 

Gapped
Lambda     K      H
   0.267   0.0410    0.140 


Matrix: BLOSUM62
Gap Penalties: Existence: 11, Extension: 1
Number of Hits to DB: 43,592,725
Number of Sequences: 37866
Number of extensions: 3099645
Number of successful extensions: 30743
Number of sequences better than 10.0: 30
Number of HSP's better than 10.0 without gapping: 257
Number of HSP's successfully gapped in prelim test: 1901
Number of HSP's that attempted gapping in prelim test: 17938
Number of HSP's gapped (non-prelim): 11413
length of query: 779
length of database: 18,247,518
effective HSP length: 110
effective length of query: 669
effective length of database: 14,082,258
effective search space: 9421030602
effective search space used: 9421030602
T: 11
A: 40
X1: 16 ( 7.2 bits)
X2: 38 (14.6 bits)
X3: 64 (24.7 bits)
S1: 42 (21.9 bits)
S2: 66 (30.0 bits)

Search results were obtained with NCBI BLAST and RefSeq entries.


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Guide to the Human Genome
Copyright © 2010 by Stewart Scherer. All rights reserved.

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