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Search of human proteins with 116089335
BLASTP 2.2.11 [Jun-05-2005]
Reference: Altschul, Stephen F., Thomas L. Madden, Alejandro A. Schaffer,
Jinghui Zhang, Zheng Zhang, Webb Miller, and David J. Lipman (1997),
"Gapped BLAST and PSI-BLAST: a new generation of protein database search
programs", Nucleic Acids Res. 25:3389-3402.
Query= gi|116089335 BR serine/threonine kinase 2 [Homo sapiens]
(668 letters)
Database: hs.faa
37,866 sequences; 18,247,518 total letters
Searching..................................................done
Score E
Sequences producing significant alignments: (bits) Value
gi|116089335 BR serine/threonine kinase 2 [Homo sapiens] 1351 0.0
gi|24308326 BR serine/threonine kinase 1 [Homo sapiens] 1064 0.0
gi|38569491 serine/threonine-protein kinase QSK [Homo sapiens] 294 2e-79
gi|38569460 SNF1-like kinase 2 [Homo sapiens] 291 1e-78
gi|254028240 MAP/microtubule affinity-regulating kinase 2 isofor... 288 1e-77
gi|254028237 MAP/microtubule affinity-regulating kinase 2 isofor... 288 1e-77
gi|254028234 MAP/microtubule affinity-regulating kinase 2 isofor... 288 1e-77
gi|254028232 MAP/microtubule affinity-regulating kinase 2 isofor... 288 1e-77
gi|86990441 MAP/microtubule affinity-regulating kinase 2 isoform... 288 1e-77
gi|116256471 SNF1-like kinase [Homo sapiens] 288 1e-77
gi|193083129 MAP/microtubule affinity-regulating kinase 3 isofor... 283 5e-76
gi|193083127 MAP/microtubule affinity-regulating kinase 3 isofor... 281 1e-75
gi|193083125 MAP/microtubule affinity-regulating kinase 3 isofor... 281 1e-75
gi|46852166 MAP/microtubule affinity-regulating kinase 3 isoform... 281 1e-75
gi|33636756 MAP/microtubule affinity-regulating kinase 4 [Homo s... 280 3e-75
gi|153791472 MAP/microtubule affinity-regulating kinase 1 [Homo ... 278 1e-74
gi|94557301 protein kinase, AMP-activated, alpha 1 catalytic sub... 276 6e-74
gi|46877068 AMP-activated protein kinase alpha 2 catalytic subun... 273 5e-73
gi|94557299 protein kinase, AMP-activated, alpha 1 catalytic sub... 266 6e-71
gi|7661974 maternal embryonic leucine zipper kinase [Homo sapiens] 229 8e-60
gi|7662170 AMPK-related protein kinase 5 [Homo sapiens] 225 1e-58
gi|13569922 NUAK family, SNF1-like kinase, 2 [Homo sapiens] 218 1e-56
gi|156105707 SNF related kinase [Homo sapiens] 217 2e-56
gi|156105705 SNF related kinase [Homo sapiens] 217 2e-56
gi|23503303 serine/threonine-protein kinase NIM1 [Homo sapiens] 198 2e-50
gi|7657214 hormonally upregulated Neu-associated kinase [Homo sa... 191 2e-48
gi|212549756 calcium/calmodulin-dependent protein kinase II delt... 183 5e-46
gi|26667183 calcium/calmodulin-dependent protein kinase II delta... 183 5e-46
gi|212549753 calcium/calmodulin-dependent protein kinase II delt... 183 5e-46
gi|26667186 calcium/calmodulin-dependent protein kinase II delta... 183 5e-46
>gi|116089335 BR serine/threonine kinase 2 [Homo sapiens]
Length = 668
Score = 1351 bits (3497), Expect = 0.0
Identities = 668/668 (100%), Positives = 668/668 (100%)
Query: 1 MTSTGKDGGAQHAQYVGPYRLEKTLGKGQTGLVKLGVHCVTCQKVAIKIVNREKLSESVL 60
MTSTGKDGGAQHAQYVGPYRLEKTLGKGQTGLVKLGVHCVTCQKVAIKIVNREKLSESVL
Sbjct: 1 MTSTGKDGGAQHAQYVGPYRLEKTLGKGQTGLVKLGVHCVTCQKVAIKIVNREKLSESVL 60
Query: 61 MKVEREIAILKLIEHPHVLKLHDVYENKKYLYLVLEHVSGGELFDYLVKKGRLTPKEARK 120
MKVEREIAILKLIEHPHVLKLHDVYENKKYLYLVLEHVSGGELFDYLVKKGRLTPKEARK
Sbjct: 61 MKVEREIAILKLIEHPHVLKLHDVYENKKYLYLVLEHVSGGELFDYLVKKGRLTPKEARK 120
Query: 121 FFRQIISALDFCHSHSICHRDLKPENLLLDEKNNIRIADFGMASLQVGDSLLETSCGSPH 180
FFRQIISALDFCHSHSICHRDLKPENLLLDEKNNIRIADFGMASLQVGDSLLETSCGSPH
Sbjct: 121 FFRQIISALDFCHSHSICHRDLKPENLLLDEKNNIRIADFGMASLQVGDSLLETSCGSPH 180
Query: 181 YACPEVIRGEKYDGRKADVWSCGVILFALLVGALPFDDDNLRQLLEKVKRGVFHMPHFIP 240
YACPEVIRGEKYDGRKADVWSCGVILFALLVGALPFDDDNLRQLLEKVKRGVFHMPHFIP
Sbjct: 181 YACPEVIRGEKYDGRKADVWSCGVILFALLVGALPFDDDNLRQLLEKVKRGVFHMPHFIP 240
Query: 241 PDCQSLLRGMIEVDAARRLTLEHIQKHIWYIGGKNEPEPEQPIPRKVQIRSLPSLEDIDP 300
PDCQSLLRGMIEVDAARRLTLEHIQKHIWYIGGKNEPEPEQPIPRKVQIRSLPSLEDIDP
Sbjct: 241 PDCQSLLRGMIEVDAARRLTLEHIQKHIWYIGGKNEPEPEQPIPRKVQIRSLPSLEDIDP 300
Query: 301 DVLDSMHSLGCFRDRNKLLQDLLSEEENQEKMIYFLLLDRKERYPSQEDEDLPPRNEIDP 360
DVLDSMHSLGCFRDRNKLLQDLLSEEENQEKMIYFLLLDRKERYPSQEDEDLPPRNEIDP
Sbjct: 301 DVLDSMHSLGCFRDRNKLLQDLLSEEENQEKMIYFLLLDRKERYPSQEDEDLPPRNEIDP 360
Query: 361 PRKRVDSPMLNRHGKRRPERKSMEVLSVTDGGSPVPARRAIEMAQHGQRSRSISGASSGL 420
PRKRVDSPMLNRHGKRRPERKSMEVLSVTDGGSPVPARRAIEMAQHGQRSRSISGASSGL
Sbjct: 361 PRKRVDSPMLNRHGKRRPERKSMEVLSVTDGGSPVPARRAIEMAQHGQRSRSISGASSGL 420
Query: 421 STSPLSSPRVTPHPSPRGSPLPTPKGTPVHTPKESPAGTPNPTPPSSPSVGGVPWRARLN 480
STSPLSSPRVTPHPSPRGSPLPTPKGTPVHTPKESPAGTPNPTPPSSPSVGGVPWRARLN
Sbjct: 421 STSPLSSPRVTPHPSPRGSPLPTPKGTPVHTPKESPAGTPNPTPPSSPSVGGVPWRARLN 480
Query: 481 SIKNSFLGSPRFHRRKLQVPTPEEMSNLTPESSPELAKKSWFGNFISLEKEEQIFVVIKD 540
SIKNSFLGSPRFHRRKLQVPTPEEMSNLTPESSPELAKKSWFGNFISLEKEEQIFVVIKD
Sbjct: 481 SIKNSFLGSPRFHRRKLQVPTPEEMSNLTPESSPELAKKSWFGNFISLEKEEQIFVVIKD 540
Query: 541 KPLSSIKADIVHAFLSIPSLSHSVISQTSFRAEYKATGGPAVFQKPVKFQVDITYTEGGE 600
KPLSSIKADIVHAFLSIPSLSHSVISQTSFRAEYKATGGPAVFQKPVKFQVDITYTEGGE
Sbjct: 541 KPLSSIKADIVHAFLSIPSLSHSVISQTSFRAEYKATGGPAVFQKPVKFQVDITYTEGGE 600
Query: 601 AQKENGIYSVTFTLLSGPSRRFKRVVETIQAQLLSTHDPPAAQHLSDTTNCMEMMTGRLS 660
AQKENGIYSVTFTLLSGPSRRFKRVVETIQAQLLSTHDPPAAQHLSDTTNCMEMMTGRLS
Sbjct: 601 AQKENGIYSVTFTLLSGPSRRFKRVVETIQAQLLSTHDPPAAQHLSDTTNCMEMMTGRLS 660
Query: 661 KCGIIPKS 668
KCGIIPKS
Sbjct: 661 KCGIIPKS 668
>gi|24308326 BR serine/threonine kinase 1 [Homo sapiens]
Length = 778
Score = 1064 bits (2751), Expect = 0.0
Identities = 548/730 (75%), Positives = 602/730 (82%), Gaps = 80/730 (10%)
Query: 1 MTSTGKDGGA---------------QHAQYVGPYRLEKTLGKGQTGLVKLGVHCVTCQKV 45
M+S K+GG QHAQYVGPYRLEKTLGKGQTGLVKLGVHC+T QKV
Sbjct: 1 MSSGAKEGGGGSPAYHLPHPHPHPPQHAQYVGPYRLEKTLGKGQTGLVKLGVHCITGQKV 60
Query: 46 AIKIVNREKLSESVLMKVEREIAILKLIEHPHVLKLHDVYENKKYLYLVLEHVSGGELFD 105
AIKIVNREKLSESVLMKVEREIAILKLIEHPHVLKLHDVYENKKYLYLVLEHVSGGELFD
Sbjct: 61 AIKIVNREKLSESVLMKVEREIAILKLIEHPHVLKLHDVYENKKYLYLVLEHVSGGELFD 120
Query: 106 YLVKKGRLTPKEARKFFRQIISALDFCHSHSICHRDLKPENLLLDEKNNIRIADFGMASL 165
YLVKKGRLTPKEARKFFRQI+SALDFCHS+SICHRDLKPENLLLDEKNNIRIADFGMASL
Sbjct: 121 YLVKKGRLTPKEARKFFRQIVSALDFCHSYSICHRDLKPENLLLDEKNNIRIADFGMASL 180
Query: 166 QVGDSLLETSCGSPHYACPEVIRGEKYDGRKADVWSCGVILFALLVGALPFDDDNLRQLL 225
QVGDSLLETSCGSPHYACPEVI+GEKYDGR+AD+WSCGVILFALLVGALPFDDDNLRQLL
Sbjct: 181 QVGDSLLETSCGSPHYACPEVIKGEKYDGRRADMWSCGVILFALLVGALPFDDDNLRQLL 240
Query: 226 EKVKRGVFHMPHFIPPDCQSLLRGMIEVDAARRLTLEHIQKHIWYIGGKNEPEP-EQPIP 284
EKVKRGVFHMPHFIPPDCQSLLRGMIEV+ +RL+LE IQKH WY+GGK+EP+P +P P
Sbjct: 241 EKVKRGVFHMPHFIPPDCQSLLRGMIEVEPEKRLSLEQIQKHPWYLGGKHEPDPCLEPAP 300
Query: 285 -RKVQIRSLPSLEDIDPDVLDSMHSLGCFRDRNKLLQDLLSEEENQEKMIYFLLLDRKER 343
R+V +RSLPS ++DPDVL+SM SLGCFRDR +L ++L SEEENQEKMIY+LLLDRKER
Sbjct: 301 GRRVAMRSLPSNGELDPDVLESMASLGCFRDRERLHRELRSEEENQEKMIYYLLLDRKER 360
Query: 344 YPSQEDEDLPPRNEIDPPRKRVDSPMLNRHGKRRPERKSMEVLSVTD---GGSPVPARRA 400
YPS ED+DLPPRN++DPPRKRVDSPML+RHGKRRPERKSMEVLS+TD GGSPVP RRA
Sbjct: 361 YPSCEDQDLPPRNDVDPPRKRVDSPMLSRHGKRRPERKSMEVLSITDAGGGGSPVPTRRA 420
Query: 401 IEMAQHGQRSRSISGASSGLSTSPLSSPR------------------------------- 429
+EMAQH QRSRS+SGAS+GLS+SPLSSPR
Sbjct: 421 LEMAQHSQRSRSVSGASTGLSSSPLSSPRSPVFSFSPEPGAGDEARGGGSPTSKTQTLPS 480
Query: 430 ----------VTPHPSPRGSPLPTPKG-----------TPVHTPKESPAGTPNPTPPSSP 468
P PS R +PLP P G +P+HTP+ SP GTP TPP SP
Sbjct: 481 RGPRGGGAGEQPPPPSARSTPLPGPPGSPRSSGGTPLHSPLHTPRASPTGTPGTTPPPSP 540
Query: 469 --SVGGVPWRARLNSIKNSFLGSPRFHRRKLQVPTPEEMSNLTPESSPELAKKSWFGNFI 526
VGG WR+RLNSI+NSFLGSPRFHRRK+QVPT EEMS+LTPESSPELAK+SWFGNFI
Sbjct: 541 GGGVGGAAWRSRLNSIRNSFLGSPRFHRRKMQVPTAEEMSSLTPESSPELAKRSWFGNFI 600
Query: 527 SLEKEEQIFVVIKDKPLSSIKADIVHAFLSIPSLSHSVISQTSFRAEYKATGGPAVFQKP 586
SL+KEEQIF+V+KDKPLSSIKADIVHAFLSIPSLSHSV+SQTSFRAEYKA+GGP+VFQKP
Sbjct: 601 SLDKEEQIFLVLKDKPLSSIKADIVHAFLSIPSLSHSVLSQTSFRAEYKASGGPSVFQKP 660
Query: 587 VKFQVDITYTEGGEAQKE------NGIYSVTFTLLSGPSRRFKRVVETIQAQLLSTHDPP 640
V+FQVDI+ +EG E GIYSVTFTL+SGPSRRFKRVVETIQAQLLSTHD P
Sbjct: 661 VRFQVDISSSEGPEPSPRRDGSGGGGIYSVTFTLISGPSRRFKRVVETIQAQLLSTHDQP 720
Query: 641 AAQHLSDTTN 650
+ Q L+D N
Sbjct: 721 SVQALADEKN 730
>gi|38569491 serine/threonine-protein kinase QSK [Homo sapiens]
Length = 1263
Score = 294 bits (752), Expect = 2e-79
Identities = 147/338 (43%), Positives = 220/338 (65%), Gaps = 2/338 (0%)
Query: 16 VGPYRLEKTLGKGQTGLVKLGVHCVTCQKVAIKIVNREKLSESVLMKVEREIAILKLIEH 75
+G Y +++T+GKG +VK H VT KVAIKI+++ +L E L K+ RE+ I+K++ H
Sbjct: 5 IGYYEIDRTIGKGNFAVVKRATHLVTKAKVAIKIIDKTQLDEENLKKIFREVQIMKMLCH 64
Query: 76 PHVLKLHDVYENKKYLYLVLEHVSGGELFDYLVKKGRLTPKEARKFFRQIISALDFCHSH 135
PH+++L+ V E ++ +YLV E+ SGGE+FD+LV GR+ KEAR+ F+QI++A+ FCH
Sbjct: 65 PHIIRLYQVMETERMIYLVTEYASGGEIFDHLVAHGRMAEKEARRKFKQIVTAVYFCHCR 124
Query: 136 SICHRDLKPENLLLDEKNNIRIADFGMASLQVGDSLLETSCGSPHYACPEVIRGEKYDGR 195
+I HRDLK ENLLLD NI+IADFG ++L LL+T CGSP YA PE+ G++YDG
Sbjct: 125 NIVHRDLKAENLLLDANLNIKIADFGFSNLFTPGQLLKTWCGSPPYAAPELFEGKEYDGP 184
Query: 196 KADVWSCGVILFALLVGALPFDDDNLRQLLEKVKRGVFHMPHFIPPDCQSLLRGMIEVDA 255
K D+WS GV+L+ L+ GALPFD L+ L +V G F +P F+ +C+ L+R M+ +D
Sbjct: 185 KVDIWSLGVVLYVLVCGALPFDGSTLQNLRARVLSGKFRIPFFMSTECEHLIRHMLVLDP 244
Query: 256 ARRLTLEHIQKHIWYIGGKNEPEPEQPIPRKVQIRSLPSLEDIDPDVLDSMHSLGCFRDR 315
+RL++E I KH W G +P ++ I Q++ ++ ++ DVL +M +G D+
Sbjct: 245 NKRLSMEQICKHKWMKLGDADPNFDRLIAECQQLKEERQVDPLNEDVLLAMEDMGL--DK 302
Query: 316 NKLLQDLLSEEENQEKMIYFLLLDRKERYPSQEDEDLP 353
+ LQ L S+ + IY LL DR +R+ + LP
Sbjct: 303 EQTLQSLRSDAYDHYSAIYSLLCDRHKRHKTLRLGALP 340
>gi|38569460 SNF1-like kinase 2 [Homo sapiens]
Length = 926
Score = 291 bits (746), Expect = 1e-78
Identities = 154/360 (42%), Positives = 223/360 (61%), Gaps = 13/360 (3%)
Query: 9 GAQHAQY----VGPYRLEKTLGKGQTGLVKLGVHCVTCQKVAIKIVNREKLSESVLMKVE 64
G +H Q VG Y +E TLGKG +VKLG H +T +VAIKI+++ +L L K+
Sbjct: 6 GPRHLQRGPVRVGFYDIEGTLGKGNFAVVKLGRHRITKTEVAIKIIDKSQLDAVNLEKIY 65
Query: 65 REIAILKLIEHPHVLKLHDVYENKKYLYLVLEHVSGGELFDYLVKKGRLTPKEARKFFRQ 124
RE+ I+K+++HPH++KL+ V E K LYLV E+ GE+FDYL GRL EAR+ F Q
Sbjct: 66 REVQIMKMLDHPHIIKLYQVMETKSMLYLVTEYAKNGEIFDYLANHGRLNESEARRKFWQ 125
Query: 125 IISALDFCHSHSICHRDLKPENLLLDEKNNIRIADFGMASLQVGDSLLETSCGSPHYACP 184
I+SA+D+CH I HRDLK ENLLLD NI+IADFG + LL T CGSP YA P
Sbjct: 126 ILSAVDYCHGRKIVHRDLKAENLLLDNNMNIKIADFGFGNFFKSGELLATWCGSPPYAAP 185
Query: 185 EVIRGEKYDGRKADVWSCGVILFALLVGALPFDDDNLRQLLEKVKRGVFHMPHFIPPDCQ 244
EV G++Y+G + D+WS GV+L+ L+ GALPFD L L ++V G F +P+F+ DC+
Sbjct: 186 EVFEGQQYEGPQLDIWSMGVVLYVLVCGALPFDGPTLPILRQRVLEGRFRIPYFMSEDCE 245
Query: 245 SLLRGMIEVDAARRLTLEHIQKHIWYIGGKNEPEPEQPIPRKVQIRSLPSLEDIDPDVLD 304
L+R M+ +D ++RLT+ I++H W + E ++P+ + + PS+ + + VL
Sbjct: 246 HLIRRMLVLDPSKRLTIAQIKEHKWML---IEVPVQRPVLYPQEQENEPSIGEFNEQVLR 302
Query: 305 SMHSLGCFRDRNKLLQDLLSEEENQEKMIYFLLLDRKERYPSQEDEDLPPRNEIDPPRKR 364
MHSLG D+ K ++ L ++ N IYFLL++R + + S P +D ++R
Sbjct: 303 LMHSLGI--DQQKTIESLQNKSYNHFAAIYFLLVERLKSHRS----SFPVEQRLDGRQRR 356
>gi|254028240 MAP/microtubule affinity-regulating kinase 2 isoform f
[Homo sapiens]
Length = 709
Score = 288 bits (736), Expect = 1e-77
Identities = 170/446 (38%), Positives = 247/446 (55%), Gaps = 21/446 (4%)
Query: 10 AQHAQYVGPYRLEKTLGKGQTGLVKLGVHCVTCQKVAIKIVNREKLSESVLMKVEREIAI 69
A ++G YRL KT+GKG VKL H +T ++VA+KI+++ +L+ S L K+ RE+ I
Sbjct: 44 ADEQPHIGNYRLLKTIGKGNFAKVKLARHILTGKEVAVKIIDKTQLNSSSLQKLFREVRI 103
Query: 70 LKLIEHPHVLKLHDVYENKKYLYLVLEHVSGGELFDYLVKKGRLTPKEARKFFRQIISAL 129
+K++ HP+++KL +V E +K LYLV+E+ SGGE+FDYLV GR+ KEAR FRQI+SA+
Sbjct: 104 MKVLNHPNIVKLFEVIETEKTLYLVMEYASGGEVFDYLVAHGRMKEKEARAKFRQIVSAV 163
Query: 130 DFCHSHSICHRDLKPENLLLDEKNNIRIADFGMASLQVGDSLLETSCGSPHYACPEVIRG 189
+CH I HRDLK ENLLLD NI+IADFG ++ + L+T CGSP YA PE+ +G
Sbjct: 164 QYCHQKFIVHRDLKAENLLLDADMNIKIADFGFSNEFTFGNKLDTFCGSPPYAAPELFQG 223
Query: 190 EKYDGRKADVWSCGVILFALLVGALPFDDDNLRQLLEKVKRGVFHMPHFIPPDCQSLLRG 249
+KYDG + DVWS GVIL+ L+ G+LPFD NL++L E+V RG + +P ++ DC++LL+
Sbjct: 224 KKYDGPEVDVWSLGVILYTLVSGSLPFDGQNLKELRERVLRGKYRIPFYMSTDCENLLKK 283
Query: 250 MIEVDAARRLTLEHIQKHIWYIGGKNEPEPEQPIPRKVQIRSLPSLEDIDPDVLDSMHSL 309
+ ++ ++R TLE I K W G + E K + LP + DP + M S+
Sbjct: 284 FLILNPSKRGTLEQIMKDRWMNVGHEDDE------LKPYVEPLPDYK--DPRRTELMVSM 335
Query: 310 GCFRDRNKLLQDLLSEEENQEKMIYFLLLDRKERYPSQEDEDLPPRNEIDPPRKRVDSP- 368
G R+ +QD L + E M +LLL K + L PR D SP
Sbjct: 336 GYTREE---IQDSLVGQRYNEVMATYLLLGYKSSELEGDTITLKPRPSADLTNSSAPSPS 392
Query: 369 -MLNRHGKRRPERKSMEVLSVTDGGSPVPARRAIE---MAQHGQRSRSISGASSGLSTSP 424
+ R P+++ G +P + + + + R SG S
Sbjct: 393 HKVQRSVSANPKQRRFS----DQAGPAIPTSNSYSKKTQSNNAENKRPEEDRESGRKASS 448
Query: 425 LSSPRVTPHPS-PRGSPLPTPKGTPV 449
+ +P P R PTP V
Sbjct: 449 TAKVPASPLPGLERKKTTPTPSTNSV 474
>gi|254028237 MAP/microtubule affinity-regulating kinase 2 isoform e
[Homo sapiens]
Length = 719
Score = 288 bits (736), Expect = 1e-77
Identities = 171/446 (38%), Positives = 248/446 (55%), Gaps = 20/446 (4%)
Query: 10 AQHAQYVGPYRLEKTLGKGQTGLVKLGVHCVTCQKVAIKIVNREKLSESVLMKVEREIAI 69
A ++G YRL KT+GKG VKL H +T ++VA+KI+++ +L+ S L K+ RE+ I
Sbjct: 44 ADEQPHIGNYRLLKTIGKGNFAKVKLARHILTGKEVAVKIIDKTQLNSSSLQKLFREVRI 103
Query: 70 LKLIEHPHVLKLHDVYENKKYLYLVLEHVSGGELFDYLVKKGRLTPKEARKFFRQIISAL 129
+K++ HP+++KL +V E +K LYLV+E+ SGGE+FDYLV GR+ KEAR FRQI+SA+
Sbjct: 104 MKVLNHPNIVKLFEVIETEKTLYLVMEYASGGEVFDYLVAHGRMKEKEARAKFRQIVSAV 163
Query: 130 DFCHSHSICHRDLKPENLLLDEKNNIRIADFGMASLQVGDSLLETSCGSPHYACPEVIRG 189
+CH I HRDLK ENLLLD NI+IADFG ++ + L+T CGSP YA PE+ +G
Sbjct: 164 QYCHQKFIVHRDLKAENLLLDADMNIKIADFGFSNEFTFGNKLDTFCGSPPYAAPELFQG 223
Query: 190 EKYDGRKADVWSCGVILFALLVGALPFDDDNLRQLLEKVKRGVFHMPHFIPPDCQSLLRG 249
+KYDG + DVWS GVIL+ L+ G+LPFD NL++L E+V RG + +P ++ DC++LL+
Sbjct: 224 KKYDGPEVDVWSLGVILYTLVSGSLPFDGQNLKELRERVLRGKYRIPFYMSTDCENLLKK 283
Query: 250 MIEVDAARRLTLEHIQKHIWYIGGKNEPEPEQPIPRKVQIRSLPSLEDIDPDVLDSMHSL 309
+ ++ ++R TLE I K W G + E K + LP + DP + M S+
Sbjct: 284 FLILNPSKRGTLEQIMKDRWMNVGHEDDE------LKPYVEPLPDYK--DPRRTELMVSM 335
Query: 310 GCFRDRNKLLQDLLSEEENQEKMIYFLLLDRKERYPSQEDEDLPPRNEIDPPRKRVDSP- 368
G R+ +QD L + E M +LLL K + L PR D SP
Sbjct: 336 GYTREE---IQDSLVGQRYNEVMATYLLLGYKSSELEGDTITLKPRPSADLTNSSAPSPS 392
Query: 369 -MLNRHGKRRPERKSMEVLSVTDGGSPVPARRAIE---MAQHGQRSRSISGASSGLSTSP 424
+ R P+++ S G +P + + + + R SG S
Sbjct: 393 HKVQRSVSANPKQRR---FSDQAAGPAIPTSNSYSKKTQSNNAENKRPEEDRESGRKASS 449
Query: 425 LSSPRVTPHPS-PRGSPLPTPKGTPV 449
+ +P P R PTP V
Sbjct: 450 TAKVPASPLPGLERKKTTPTPSTNSV 475
>gi|254028234 MAP/microtubule affinity-regulating kinase 2 isoform d
[Homo sapiens]
Length = 788
Score = 288 bits (736), Expect = 1e-77
Identities = 171/446 (38%), Positives = 248/446 (55%), Gaps = 20/446 (4%)
Query: 10 AQHAQYVGPYRLEKTLGKGQTGLVKLGVHCVTCQKVAIKIVNREKLSESVLMKVEREIAI 69
A ++G YRL KT+GKG VKL H +T ++VA+KI+++ +L+ S L K+ RE+ I
Sbjct: 44 ADEQPHIGNYRLLKTIGKGNFAKVKLARHILTGKEVAVKIIDKTQLNSSSLQKLFREVRI 103
Query: 70 LKLIEHPHVLKLHDVYENKKYLYLVLEHVSGGELFDYLVKKGRLTPKEARKFFRQIISAL 129
+K++ HP+++KL +V E +K LYLV+E+ SGGE+FDYLV GR+ KEAR FRQI+SA+
Sbjct: 104 MKVLNHPNIVKLFEVIETEKTLYLVMEYASGGEVFDYLVAHGRMKEKEARAKFRQIVSAV 163
Query: 130 DFCHSHSICHRDLKPENLLLDEKNNIRIADFGMASLQVGDSLLETSCGSPHYACPEVIRG 189
+CH I HRDLK ENLLLD NI+IADFG ++ + L+T CGSP YA PE+ +G
Sbjct: 164 QYCHQKFIVHRDLKAENLLLDADMNIKIADFGFSNEFTFGNKLDTFCGSPPYAAPELFQG 223
Query: 190 EKYDGRKADVWSCGVILFALLVGALPFDDDNLRQLLEKVKRGVFHMPHFIPPDCQSLLRG 249
+KYDG + DVWS GVIL+ L+ G+LPFD NL++L E+V RG + +P ++ DC++LL+
Sbjct: 224 KKYDGPEVDVWSLGVILYTLVSGSLPFDGQNLKELRERVLRGKYRIPFYMSTDCENLLKK 283
Query: 250 MIEVDAARRLTLEHIQKHIWYIGGKNEPEPEQPIPRKVQIRSLPSLEDIDPDVLDSMHSL 309
+ ++ ++R TLE I K W G + E K + LP + DP + M S+
Sbjct: 284 FLILNPSKRGTLEQIMKDRWMNVGHEDDE------LKPYVEPLPDYK--DPRRTELMVSM 335
Query: 310 GCFRDRNKLLQDLLSEEENQEKMIYFLLLDRKERYPSQEDEDLPPRNEIDPPRKRVDSP- 368
G R+ +QD L + E M +LLL K + L PR D SP
Sbjct: 336 GYTREE---IQDSLVGQRYNEVMATYLLLGYKSSELEGDTITLKPRPSADLTNSSAPSPS 392
Query: 369 -MLNRHGKRRPERKSMEVLSVTDGGSPVPARRAIE---MAQHGQRSRSISGASSGLSTSP 424
+ R P+++ S G +P + + + + R SG S
Sbjct: 393 HKVQRSVSANPKQRR---FSDQAAGPAIPTSNSYSKKTQSNNAENKRPEEDRESGRKASS 449
Query: 425 LSSPRVTPHPS-PRGSPLPTPKGTPV 449
+ +P P R PTP V
Sbjct: 450 TAKVPASPLPGLERKKTTPTPSTNSV 475
>gi|254028232 MAP/microtubule affinity-regulating kinase 2 isoform c
[Homo sapiens]
Length = 724
Score = 288 bits (736), Expect = 1e-77
Identities = 170/446 (38%), Positives = 247/446 (55%), Gaps = 21/446 (4%)
Query: 10 AQHAQYVGPYRLEKTLGKGQTGLVKLGVHCVTCQKVAIKIVNREKLSESVLMKVEREIAI 69
A ++G YRL KT+GKG VKL H +T ++VA+KI+++ +L+ S L K+ RE+ I
Sbjct: 44 ADEQPHIGNYRLLKTIGKGNFAKVKLARHILTGKEVAVKIIDKTQLNSSSLQKLFREVRI 103
Query: 70 LKLIEHPHVLKLHDVYENKKYLYLVLEHVSGGELFDYLVKKGRLTPKEARKFFRQIISAL 129
+K++ HP+++KL +V E +K LYLV+E+ SGGE+FDYLV GR+ KEAR FRQI+SA+
Sbjct: 104 MKVLNHPNIVKLFEVIETEKTLYLVMEYASGGEVFDYLVAHGRMKEKEARAKFRQIVSAV 163
Query: 130 DFCHSHSICHRDLKPENLLLDEKNNIRIADFGMASLQVGDSLLETSCGSPHYACPEVIRG 189
+CH I HRDLK ENLLLD NI+IADFG ++ + L+T CGSP YA PE+ +G
Sbjct: 164 QYCHQKFIVHRDLKAENLLLDADMNIKIADFGFSNEFTFGNKLDTFCGSPPYAAPELFQG 223
Query: 190 EKYDGRKADVWSCGVILFALLVGALPFDDDNLRQLLEKVKRGVFHMPHFIPPDCQSLLRG 249
+KYDG + DVWS GVIL+ L+ G+LPFD NL++L E+V RG + +P ++ DC++LL+
Sbjct: 224 KKYDGPEVDVWSLGVILYTLVSGSLPFDGQNLKELRERVLRGKYRIPFYMSTDCENLLKK 283
Query: 250 MIEVDAARRLTLEHIQKHIWYIGGKNEPEPEQPIPRKVQIRSLPSLEDIDPDVLDSMHSL 309
+ ++ ++R TLE I K W G + E K + LP + DP + M S+
Sbjct: 284 FLILNPSKRGTLEQIMKDRWMNVGHEDDE------LKPYVEPLPDYK--DPRRTELMVSM 335
Query: 310 GCFRDRNKLLQDLLSEEENQEKMIYFLLLDRKERYPSQEDEDLPPRNEIDPPRKRVDSP- 368
G R+ +QD L + E M +LLL K + L PR D SP
Sbjct: 336 GYTREE---IQDSLVGQRYNEVMATYLLLGYKSSELEGDTITLKPRPSADLTNSSAPSPS 392
Query: 369 -MLNRHGKRRPERKSMEVLSVTDGGSPVPARRAIE---MAQHGQRSRSISGASSGLSTSP 424
+ R P+++ G +P + + + + R SG S
Sbjct: 393 HKVQRSVSANPKQRRFS----DQAGPAIPTSNSYSKKTQSNNAENKRPEEDRESGRKASS 448
Query: 425 LSSPRVTPHPS-PRGSPLPTPKGTPV 449
+ +P P R PTP V
Sbjct: 449 TAKVPASPLPGLERKKTTPTPSTNSV 474
>gi|86990441 MAP/microtubule affinity-regulating kinase 2 isoform a
[Homo sapiens]
Length = 745
Score = 288 bits (736), Expect = 1e-77
Identities = 170/446 (38%), Positives = 247/446 (55%), Gaps = 21/446 (4%)
Query: 10 AQHAQYVGPYRLEKTLGKGQTGLVKLGVHCVTCQKVAIKIVNREKLSESVLMKVEREIAI 69
A ++G YRL KT+GKG VKL H +T ++VA+KI+++ +L+ S L K+ RE+ I
Sbjct: 11 ADEQPHIGNYRLLKTIGKGNFAKVKLARHILTGKEVAVKIIDKTQLNSSSLQKLFREVRI 70
Query: 70 LKLIEHPHVLKLHDVYENKKYLYLVLEHVSGGELFDYLVKKGRLTPKEARKFFRQIISAL 129
+K++ HP+++KL +V E +K LYLV+E+ SGGE+FDYLV GR+ KEAR FRQI+SA+
Sbjct: 71 MKVLNHPNIVKLFEVIETEKTLYLVMEYASGGEVFDYLVAHGRMKEKEARAKFRQIVSAV 130
Query: 130 DFCHSHSICHRDLKPENLLLDEKNNIRIADFGMASLQVGDSLLETSCGSPHYACPEVIRG 189
+CH I HRDLK ENLLLD NI+IADFG ++ + L+T CGSP YA PE+ +G
Sbjct: 131 QYCHQKFIVHRDLKAENLLLDADMNIKIADFGFSNEFTFGNKLDTFCGSPPYAAPELFQG 190
Query: 190 EKYDGRKADVWSCGVILFALLVGALPFDDDNLRQLLEKVKRGVFHMPHFIPPDCQSLLRG 249
+KYDG + DVWS GVIL+ L+ G+LPFD NL++L E+V RG + +P ++ DC++LL+
Sbjct: 191 KKYDGPEVDVWSLGVILYTLVSGSLPFDGQNLKELRERVLRGKYRIPFYMSTDCENLLKK 250
Query: 250 MIEVDAARRLTLEHIQKHIWYIGGKNEPEPEQPIPRKVQIRSLPSLEDIDPDVLDSMHSL 309
+ ++ ++R TLE I K W G + E K + LP + DP + M S+
Sbjct: 251 FLILNPSKRGTLEQIMKDRWMNVGHEDDE------LKPYVEPLPDYK--DPRRTELMVSM 302
Query: 310 GCFRDRNKLLQDLLSEEENQEKMIYFLLLDRKERYPSQEDEDLPPRNEIDPPRKRVDSP- 368
G R+ +QD L + E M +LLL K + L PR D SP
Sbjct: 303 GYTREE---IQDSLVGQRYNEVMATYLLLGYKSSELEGDTITLKPRPSADLTNSSAPSPS 359
Query: 369 -MLNRHGKRRPERKSMEVLSVTDGGSPVPARRAIE---MAQHGQRSRSISGASSGLSTSP 424
+ R P+++ G +P + + + + R SG S
Sbjct: 360 HKVQRSVSANPKQRRFS----DQAGPAIPTSNSYSKKTQSNNAENKRPEEDRESGRKASS 415
Query: 425 LSSPRVTPHPS-PRGSPLPTPKGTPV 449
+ +P P R PTP V
Sbjct: 416 TAKVPASPLPGLERKKTTPTPSTNSV 441
>gi|116256471 SNF1-like kinase [Homo sapiens]
Length = 783
Score = 288 bits (736), Expect = 1e-77
Identities = 151/340 (44%), Positives = 208/340 (61%), Gaps = 4/340 (1%)
Query: 5 GKDGGAQHAQYVGPYRLEKTLGKGQTGLVKLGVHCVTCQKVAIKIVNREKLSESVLMKVE 64
G+ G Q VG Y +E+TLGKG +VKL H VT +VAIKI+++ +L S L K+
Sbjct: 13 GQGQGQQKPLRVGFYDIERTLGKGNFAVVKLARHRVTKTQVAIKIIDKTRLDSSNLEKIY 72
Query: 65 REIAILKLIEHPHVLKLHDVYENKKYLYLVLEHVSGGELFDYLVKKGRLTPKEARKFFRQ 124
RE+ ++KL+ HPH++KL+ V E K LY+V E GE+FDYL G L+ EARK F Q
Sbjct: 73 REVQLMKLLNHPHIIKLYQVMETKDMLYIVTEFAKNGEMFDYLTSNGHLSENEARKKFWQ 132
Query: 125 IISALDFCHSHSICHRDLKPENLLLDEKNNIRIADFGMASLQVGDSLLETSCGSPHYACP 184
I+SA+++CH H I HRDLK ENLLLD +I++ADFG + L T CGSP YA P
Sbjct: 133 ILSAVEYCHDHHIVHRDLKTENLLLDGNMDIKLADFGFGNFYKSGEPLSTWCGSPPYAAP 192
Query: 185 EVIRGEKYDGRKADVWSCGVILFALLVGALPFDDDNLRQLLEKVKRGVFHMPHFIPPDCQ 244
EV G++Y+G + D+WS GV+L+ L+ G+LPFD NL L ++V G F +P F+ DC+
Sbjct: 193 EVFEGKEYEGPQLDIWSLGVVLYVLVCGSLPFDGPNLPTLRQRVLEGRFRIPFFMSQDCE 252
Query: 245 SLLRGMIEVDAARRLTLEHIQKHIWYIGGKNEPEPEQPIPRKVQIRSLPSLEDIDPDVLD 304
SL+R M+ VD ARR+T+ I++H W P P P S +L D D L
Sbjct: 253 SLIRRMLVVDPARRITIAQIRQHRWMRAEPCLPGPACPAFSAHSYTS--NLGDYDEQALG 310
Query: 305 SMHSLGCFRDRNKLLQDLLSEEENQEKMIYFLLLDRKERY 344
M +LG DR + ++ L + N IY+LLL+R + Y
Sbjct: 311 IMQTLGV--DRQRTVESLQNSSYNHFAAIYYLLLERLKEY 348
>gi|193083129 MAP/microtubule affinity-regulating kinase 3 isoform d
[Homo sapiens]
Length = 713
Score = 283 bits (723), Expect = 5e-76
Identities = 166/437 (37%), Positives = 249/437 (56%), Gaps = 13/437 (2%)
Query: 10 AQHAQYVGPYRLEKTLGKGQTGLVKLGVHCVTCQKVAIKIVNREKLSESVLMKVEREIAI 69
A ++G YRL KT+GKG VKL H +T ++VAIKI+++ +L+ + L K+ RE+ I
Sbjct: 47 ADEQPHIGNYRLLKTIGKGNFAKVKLARHILTGREVAIKIIDKTQLNPTSLQKLFREVRI 106
Query: 70 LKLIEHPHVLKLHDVYENKKYLYLVLEHVSGGELFDYLVKKGRLTPKEARKFFRQIISAL 129
+K++ HP+++KL +V E +K LYL++E+ SGGE+FDYLV GR+ KEAR FRQI+SA+
Sbjct: 107 MKILNHPNIVKLFEVIETEKTLYLIMEYASGGEVFDYLVAHGRMKEKEARSKFRQIVSAV 166
Query: 130 DFCHSHSICHRDLKPENLLLDEKNNIRIADFGMASLQVGDSLLETSCGSPHYACPEVIRG 189
+CH I HRDLK ENLLLD NI+IADFG ++ L+T CGSP YA PE+ +G
Sbjct: 167 QYCHQKRIVHRDLKAENLLLDADMNIKIADFGFSNEFTVGGKLDTFCGSPPYAAPELFQG 226
Query: 190 EKYDGRKADVWSCGVILFALLVGALPFDDDNLRQLLEKVKRGVFHMPHFIPPDCQSLLRG 249
+KYDG + DVWS GVIL+ L+ G+LPFD NL++L E+V RG + +P ++ DC++LL+
Sbjct: 227 KKYDGPEVDVWSLGVILYTLVSGSLPFDGQNLKELRERVLRGKYRIPFYMSTDCENLLKR 286
Query: 250 MIEVDAARRLTLEHIQKHIWYIGGKNEPEPEQPIPRKVQIRSLPSLEDIDPDVLDSMHSL 309
+ ++ +R TLE I K W G E E + + P L+ D +D M +
Sbjct: 287 FLVLNPIKRGTLEQIMKDRWINAGHEEDELKPFVE--------PELDISDQKRIDIMVGM 338
Query: 310 GCFRDRNKLLQDLLSEEENQEKMIYFLLLDRKERYPSQEDEDLPPRNEIDPPRKRVDSPM 369
G ++ +Q+ LS+ + E +LLL RK + DL P K S
Sbjct: 339 GYSQEE---IQESLSKMKYDEITATYLLLGRKSS-EVRPSSDLNNSTGQSPHHKVQRSVF 394
Query: 370 LNRHGKRRPERKSMEVLSVTDGGSPVPARRA-IEMAQHGQRSRSISGASSGLSTSPLSSP 428
++ +R + + SV A ++ + G SR SG++ G +SP
Sbjct: 395 SSQKQRRYSDHAGPAIPSVVAYPKRSQTSTADSDLKEDGISSRKSSGSAVGGKGIAPASP 454
Query: 429 RVTPHPSPRGSPLPTPK 445
+ +P + +P K
Sbjct: 455 MLGNASNPNKADIPERK 471
>gi|193083127 MAP/microtubule affinity-regulating kinase 3 isoform b
[Homo sapiens]
Length = 744
Score = 281 bits (720), Expect = 1e-75
Identities = 167/454 (36%), Positives = 253/454 (55%), Gaps = 31/454 (6%)
Query: 10 AQHAQYVGPYRLEKTLGKGQTGLVKLGVHCVTCQKVAIKIVNREKLSESVLMKVEREIAI 69
A ++G YRL KT+GKG VKL H +T ++VAIKI+++ +L+ + L K+ RE+ I
Sbjct: 47 ADEQPHIGNYRLLKTIGKGNFAKVKLARHILTGREVAIKIIDKTQLNPTSLQKLFREVRI 106
Query: 70 LKLIEHPHVLKLHDVYENKKYLYLVLEHVSGGELFDYLVKKGRLTPKEARKFFRQIISAL 129
+K++ HP+++KL +V E +K LYL++E+ SGGE+FDYLV GR+ KEAR FRQI+SA+
Sbjct: 107 MKILNHPNIVKLFEVIETEKTLYLIMEYASGGEVFDYLVAHGRMKEKEARSKFRQIVSAV 166
Query: 130 DFCHSHSICHRDLKPENLLLDEKNNIRIADFGMASLQVGDSLLETSCGSPHYACPEVIRG 189
+CH I HRDLK ENLLLD NI+IADFG ++ L+T CGSP YA PE+ +G
Sbjct: 167 QYCHQKRIVHRDLKAENLLLDADMNIKIADFGFSNEFTVGGKLDTFCGSPPYAAPELFQG 226
Query: 190 EKYDGRKADVWSCGVILFALLVGALPFDDDNLRQLLEKVKRGVFHMPHFIPPDCQSLLRG 249
+KYDG + DVWS GVIL+ L+ G+LPFD NL++L E+V RG + +P ++ DC++LL+
Sbjct: 227 KKYDGPEVDVWSLGVILYTLVSGSLPFDGQNLKELRERVLRGKYRIPFYMSTDCENLLKR 286
Query: 250 MIEVDAARRLTLEHIQKHIWYIGGKNEPEPEQPIPRKVQIRSLPSLEDIDPDVLDSMHSL 309
+ ++ +R TLE I K W G E E + + P L+ D +D M +
Sbjct: 287 FLVLNPIKRGTLEQIMKDRWINAGHEEDELKPFVE--------PELDISDQKRIDIMVGM 338
Query: 310 GCFRDRNKLLQDLLSEEENQEKMIYFLLLDRKERYPSQEDEDLPPRNEIDPPRKRVDSPM 369
G ++ +Q+ LS+ + E +LLL RK + D + + + R S +
Sbjct: 339 GYSQEE---IQESLSKMKYDEITATYLLLGRKS--SELDASDSSSSSNLSLAKVRPSSDL 393
Query: 370 LNRHGKRRPERKSMEVLS-------VTDGGSPVPARRAI-----------EMAQHGQRSR 411
N G+ + V S G +P+ A ++ + G SR
Sbjct: 394 NNSTGQSPHHKVQRSVFSSQKQRRYSDHAGPAIPSVVAYPKRSQTSTADSDLKEDGISSR 453
Query: 412 SISGASSGLSTSPLSSPRVTPHPSPRGSPLPTPK 445
SG++ G +SP + +P + +P K
Sbjct: 454 KSSGSAVGGKGIAPASPMLGNASNPNKADIPERK 487
>gi|193083125 MAP/microtubule affinity-regulating kinase 3 isoform a
[Homo sapiens]
Length = 753
Score = 281 bits (720), Expect = 1e-75
Identities = 167/454 (36%), Positives = 253/454 (55%), Gaps = 31/454 (6%)
Query: 10 AQHAQYVGPYRLEKTLGKGQTGLVKLGVHCVTCQKVAIKIVNREKLSESVLMKVEREIAI 69
A ++G YRL KT+GKG VKL H +T ++VAIKI+++ +L+ + L K+ RE+ I
Sbjct: 47 ADEQPHIGNYRLLKTIGKGNFAKVKLARHILTGREVAIKIIDKTQLNPTSLQKLFREVRI 106
Query: 70 LKLIEHPHVLKLHDVYENKKYLYLVLEHVSGGELFDYLVKKGRLTPKEARKFFRQIISAL 129
+K++ HP+++KL +V E +K LYL++E+ SGGE+FDYLV GR+ KEAR FRQI+SA+
Sbjct: 107 MKILNHPNIVKLFEVIETEKTLYLIMEYASGGEVFDYLVAHGRMKEKEARSKFRQIVSAV 166
Query: 130 DFCHSHSICHRDLKPENLLLDEKNNIRIADFGMASLQVGDSLLETSCGSPHYACPEVIRG 189
+CH I HRDLK ENLLLD NI+IADFG ++ L+T CGSP YA PE+ +G
Sbjct: 167 QYCHQKRIVHRDLKAENLLLDADMNIKIADFGFSNEFTVGGKLDTFCGSPPYAAPELFQG 226
Query: 190 EKYDGRKADVWSCGVILFALLVGALPFDDDNLRQLLEKVKRGVFHMPHFIPPDCQSLLRG 249
+KYDG + DVWS GVIL+ L+ G+LPFD NL++L E+V RG + +P ++ DC++LL+
Sbjct: 227 KKYDGPEVDVWSLGVILYTLVSGSLPFDGQNLKELRERVLRGKYRIPFYMSTDCENLLKR 286
Query: 250 MIEVDAARRLTLEHIQKHIWYIGGKNEPEPEQPIPRKVQIRSLPSLEDIDPDVLDSMHSL 309
+ ++ +R TLE I K W G E E + + P L+ D +D M +
Sbjct: 287 FLVLNPIKRGTLEQIMKDRWINAGHEEDELKPFVE--------PELDISDQKRIDIMVGM 338
Query: 310 GCFRDRNKLLQDLLSEEENQEKMIYFLLLDRKERYPSQEDEDLPPRNEIDPPRKRVDSPM 369
G ++ +Q+ LS+ + E +LLL RK + D + + + R S +
Sbjct: 339 GYSQEE---IQESLSKMKYDEITATYLLLGRKS--SELDASDSSSSSNLSLAKVRPSSDL 393
Query: 370 LNRHGKRRPERKSMEVLS-------VTDGGSPVPARRAI-----------EMAQHGQRSR 411
N G+ + V S G +P+ A ++ + G SR
Sbjct: 394 NNSTGQSPHHKVQRSVFSSQKQRRYSDHAGPAIPSVVAYPKRSQTSTADSDLKEDGISSR 453
Query: 412 SISGASSGLSTSPLSSPRVTPHPSPRGSPLPTPK 445
SG++ G +SP + +P + +P K
Sbjct: 454 KSSGSAVGGKGIAPASPMLGNASNPNKADIPERK 487
>gi|46852166 MAP/microtubule affinity-regulating kinase 3 isoform c
[Homo sapiens]
Length = 729
Score = 281 bits (720), Expect = 1e-75
Identities = 167/454 (36%), Positives = 253/454 (55%), Gaps = 31/454 (6%)
Query: 10 AQHAQYVGPYRLEKTLGKGQTGLVKLGVHCVTCQKVAIKIVNREKLSESVLMKVEREIAI 69
A ++G YRL KT+GKG VKL H +T ++VAIKI+++ +L+ + L K+ RE+ I
Sbjct: 47 ADEQPHIGNYRLLKTIGKGNFAKVKLARHILTGREVAIKIIDKTQLNPTSLQKLFREVRI 106
Query: 70 LKLIEHPHVLKLHDVYENKKYLYLVLEHVSGGELFDYLVKKGRLTPKEARKFFRQIISAL 129
+K++ HP+++KL +V E +K LYL++E+ SGGE+FDYLV GR+ KEAR FRQI+SA+
Sbjct: 107 MKILNHPNIVKLFEVIETEKTLYLIMEYASGGEVFDYLVAHGRMKEKEARSKFRQIVSAV 166
Query: 130 DFCHSHSICHRDLKPENLLLDEKNNIRIADFGMASLQVGDSLLETSCGSPHYACPEVIRG 189
+CH I HRDLK ENLLLD NI+IADFG ++ L+T CGSP YA PE+ +G
Sbjct: 167 QYCHQKRIVHRDLKAENLLLDADMNIKIADFGFSNEFTVGGKLDTFCGSPPYAAPELFQG 226
Query: 190 EKYDGRKADVWSCGVILFALLVGALPFDDDNLRQLLEKVKRGVFHMPHFIPPDCQSLLRG 249
+KYDG + DVWS GVIL+ L+ G+LPFD NL++L E+V RG + +P ++ DC++LL+
Sbjct: 227 KKYDGPEVDVWSLGVILYTLVSGSLPFDGQNLKELRERVLRGKYRIPFYMSTDCENLLKR 286
Query: 250 MIEVDAARRLTLEHIQKHIWYIGGKNEPEPEQPIPRKVQIRSLPSLEDIDPDVLDSMHSL 309
+ ++ +R TLE I K W G E E + + P L+ D +D M +
Sbjct: 287 FLVLNPIKRGTLEQIMKDRWINAGHEEDELKPFVE--------PELDISDQKRIDIMVGM 338
Query: 310 GCFRDRNKLLQDLLSEEENQEKMIYFLLLDRKERYPSQEDEDLPPRNEIDPPRKRVDSPM 369
G ++ +Q+ LS+ + E +LLL RK + D + + + R S +
Sbjct: 339 GYSQEE---IQESLSKMKYDEITATYLLLGRKS--SELDASDSSSSSNLSLAKVRPSSDL 393
Query: 370 LNRHGKRRPERKSMEVLS-------VTDGGSPVPARRAI-----------EMAQHGQRSR 411
N G+ + V S G +P+ A ++ + G SR
Sbjct: 394 NNSTGQSPHHKVQRSVFSSQKQRRYSDHAGPAIPSVVAYPKRSQTSTADSDLKEDGISSR 453
Query: 412 SISGASSGLSTSPLSSPRVTPHPSPRGSPLPTPK 445
SG++ G +SP + +P + +P K
Sbjct: 454 KSSGSAVGGKGIAPASPMLGNASNPNKADIPERK 487
>gi|33636756 MAP/microtubule affinity-regulating kinase 4 [Homo
sapiens]
Length = 688
Score = 280 bits (716), Expect = 3e-75
Identities = 176/470 (37%), Positives = 256/470 (54%), Gaps = 38/470 (8%)
Query: 15 YVGPYRLEKTLGKGQTGLVKLGVHCVTCQKVAIKIVNREKLSESVLMKVEREIAILKLIE 74
+VG YRL +T+GKG VKL H +T ++VAIKI+++ +L+ S L K+ RE+ I+K +
Sbjct: 55 HVGNYRLLRTIGKGNFAKVKLARHILTGREVAIKIIDKTQLNPSSLQKLFREVRIMKGLN 114
Query: 75 HPHVLKLHDVYENKKYLYLVLEHVSGGELFDYLVKKGRLTPKEARKFFRQIISALDFCHS 134
HP+++KL +V E +K LYLV+E+ S GE+FDYLV GR+ KEAR FRQI+SA+ +CH
Sbjct: 115 HPNIVKLFEVIETEKTLYLVMEYASAGEVFDYLVSHGRMKEKEARAKFRQIVSAVHYCHQ 174
Query: 135 HSICHRDLKPENLLLDEKNNIRIADFGMASLQVGDSLLETSCGSPHYACPEVIRGEKYDG 194
+I HRDLK ENLLLD + NI+IADFG ++ S L+T CGSP YA PE+ +G+KYDG
Sbjct: 175 KNIVHRDLKAENLLLDAEANIKIADFGFSNEFTLGSKLDTFCGSPPYAAPELFQGKKYDG 234
Query: 195 RKADVWSCGVILFALLVGALPFDDDNLRQLLEKVKRGVFHMPHFIPPDCQSLLRGMIEVD 254
+ D+WS GVIL+ L+ G+LPFD NL++L E+V RG + +P ++ DC+S+LR + ++
Sbjct: 235 PEVDIWSLGVILYTLVSGSLPFDGHNLKELRERVLRGKYRVPFYMSTDCESILRRFLVLN 294
Query: 255 AARRLTLEHIQKHIW----YIGGKNEPEPEQPIPRKVQIRSLPSLEDIDPDVLDSMHSLG 310
A+R TLE I K W Y G + +P E P + D ++ M +G
Sbjct: 295 PAKRCTLEQIMKDKWINIGYEGEELKPYTE------------PEEDFGDTKRIEVMVGMG 342
Query: 311 CFRDRNKLLQDLLSEEENQEKMIYFLLLDRKERYPSQEDEDL-PPRNEIDPPRKRVDSPM 369
R+ +++ L+ ++ E +LLL RK ++E D P + R D+
Sbjct: 343 YTREE---IKESLTSQKYNEVTATYLLLGRK----TEEGGDRGAPGLALARVRAPSDTTN 395
Query: 370 LNRHGKRRPERKSMEVLSVT----------DGGSPVPARRAIEMAQHGQ---RSRSISGA 416
K K S T G SP P G+ + + G
Sbjct: 396 GTSSSKGTSHSKGQRSSSSTYHRQRRHSDFCGPSPAPLHPKRSPTSTGEAELKEERLPGR 455
Query: 417 SSGLSTSPLSSPRVTPHPSPRGSPLPTPKGTPVHTPKESPAGTPNPTPPS 466
+ ST+ S R P SP S P + ++ TPN PPS
Sbjct: 456 KASCSTAG-SGSRGLPPSSPMVSSAHNPNKAEIPERRKDSTSTPNNLPPS 504
>gi|153791472 MAP/microtubule affinity-regulating kinase 1 [Homo
sapiens]
Length = 795
Score = 278 bits (711), Expect = 1e-74
Identities = 144/327 (44%), Positives = 215/327 (65%), Gaps = 11/327 (3%)
Query: 15 YVGPYRLEKTLGKGQTGLVKLGVHCVTCQKVAIKIVNREKLSESVLMKVEREIAILKLIE 74
++G YRL+KT+GKG VKL H +T ++VA+KI+++ +L+ + L K+ RE+ I+K++
Sbjct: 56 HIGNYRLQKTIGKGNFAKVKLARHVLTGREVAVKIIDKTQLNPTSLQKLFREVRIMKILN 115
Query: 75 HPHVLKLHDVYENKKYLYLVLEHVSGGELFDYLVKKGRLTPKEARKFFRQIISALDFCHS 134
HP+++KL +V E +K LYLV+E+ SGGE+FDYLV GR+ KEAR FRQI+SA+ +CH
Sbjct: 116 HPNIVKLFEVIETEKTLYLVMEYASGGEVFDYLVAHGRMKEKEARAKFRQIVSAVQYCHQ 175
Query: 135 HSICHRDLKPENLLLDEKNNIRIADFGMASLQVGDSLLETSCGSPHYACPEVIRGEKYDG 194
I HRDLK ENLLLD NI+IADFG ++ + L+T CGSP YA PE+ +G+KYDG
Sbjct: 176 KYIVHRDLKAENLLLDGDMNIKIADFGFSNEFTVGNKLDTFCGSPPYAAPELFQGKKYDG 235
Query: 195 RKADVWSCGVILFALLVGALPFDDDNLRQLLEKVKRGVFHMPHFIPPDCQSLLRGMIEVD 254
+ DVWS GVIL+ L+ G+LPFD NL++L E+V RG + +P ++ DC++LL+ ++ ++
Sbjct: 236 PEVDVWSLGVILYTLVSGSLPFDGQNLKELRERVLRGKYRIPFYMSTDCENLLKKLLVLN 295
Query: 255 AARRLTLEHIQKHIWYIGGKNEPEPEQPIPRKVQIRSLPSLEDIDPDVLDSMHSLGCFRD 314
+R +LE I K W G E E ++ + P + D +D M ++G RD
Sbjct: 296 PIKRGSLEQIMKDRWMNVGHEEEE--------LKPYTEPDPDFNDTKRIDIMVTMGFARD 347
Query: 315 RNKLLQDLLSEEENQEKMIYFLLLDRK 341
+ D L ++ E M ++LL RK
Sbjct: 348 E---INDALINQKYDEVMATYILLGRK 371
>gi|94557301 protein kinase, AMP-activated, alpha 1 catalytic
subunit isoform 1 [Homo sapiens]
Length = 559
Score = 276 bits (705), Expect = 6e-74
Identities = 155/368 (42%), Positives = 220/368 (59%), Gaps = 20/368 (5%)
Query: 16 VGPYRLEKTLGKGQTGLVKLGVHCVTCQKVAIKIVNREKL-SESVLMKVEREIAILKLIE 74
+G Y L TLG G G VK+G H +T KVA+KI+NR+K+ S V+ K+ REI LKL
Sbjct: 24 IGHYILGDTLGVGTFGKVKVGKHELTGHKVAVKILNRQKIRSLDVVGKIRREIQNLKLFR 83
Query: 75 HPHVLKLHDVYENKKYLYLVLEHVSGGELFDYLVKKGRLTPKEARKFFRQIISALDFCHS 134
HPH++KL+ V +++V+E+VSGGELFDY+ K GRL KE+R+ F+QI+S +D+CH
Sbjct: 84 HPHIIKLYQVISTPSDIFMVMEYVSGGELFDYICKNGRLDEKESRRLFQQILSGVDYCHR 143
Query: 135 HSICHRDLKPENLLLDEKNNIRIADFGMASLQVGDSLLETSCGSPHYACPEVIRGEKYDG 194
H + HRDLKPEN+LLD N +IADFG++++ L TSCGSP+YA PEVI G Y G
Sbjct: 144 HMVVHRDLKPENVLLDAHMNAKIADFGLSNMMSDGEFLRTSCGSPNYAAPEVISGRLYAG 203
Query: 195 RKADVWSCGVILFALLVGALPFDDDNLRQLLEKVKRGVFHMPHFIPPDCQSLLRGMIEVD 254
+ D+WS GVIL+ALL G LPFDDD++ L +K+ G+F+ P ++ P SLL+ M++VD
Sbjct: 204 PEVDIWSSGVILYALLCGTLPFDDDHVPTLFKKICDGIFYTPQYLNPSVISLLKHMLQVD 263
Query: 255 AARRLTLEHIQKHIWYIGGKNEPE---PEQPIPRKVQIRSLPSLEDIDPDVLDSMHSLGC 311
+R T++ I++H W+ ++ P+ PE P I E + L C
Sbjct: 264 PMKRATIKDIREHEWF--KQDLPKYLFPEDPSYSSTMIDDEALKEVCEKFECSEEEVLSC 321
Query: 312 FRDRNKLLQDLLSEEENQEKMIYFLLLDRKERYPSQEDEDLPPRNEIDPPRKRVDSPMLN 371
+RN QD L+ + Y L++D + +D L PP +D L
Sbjct: 322 LYNRNH--QDPLA-------VAYHLIIDNRRIMNEAKDFYL----ATSPPDSFLDDHHLT 368
Query: 372 R-HGKRRP 378
R H +R P
Sbjct: 369 RPHPERVP 376
>gi|46877068 AMP-activated protein kinase alpha 2 catalytic subunit
[Homo sapiens]
Length = 552
Score = 273 bits (697), Expect = 5e-73
Identities = 151/375 (40%), Positives = 223/375 (59%), Gaps = 28/375 (7%)
Query: 16 VGPYRLEKTLGKGQTGLVKLGVHCVTCQKVAIKIVNREKL-SESVLMKVEREIAILKLIE 74
+G Y L TLG G G VK+G H +T KVA+KI+NR+K+ S V+ K++REI LKL
Sbjct: 13 IGHYVLGDTLGVGTFGKVKIGEHQLTGHKVAVKILNRQKIRSLDVVGKIKREIQNLKLFR 72
Query: 75 HPHVLKLHDVYENKKYLYLVLEHVSGGELFDYLVKKGRLTPKEARKFFRQIISALDFCHS 134
HPH++KL+ V ++V+E+VSGGELFDY+ K GR+ EAR+ F+QI+SA+D+CH
Sbjct: 73 HPHIIKLYQVISTPTDFFMVMEYVSGGELFDYICKHGRVEEMEARRLFQQILSAVDYCHR 132
Query: 135 HSICHRDLKPENLLLDEKNNIRIADFGMASLQVGDSLLETSCGSPHYACPEVIRGEKYDG 194
H + HRDLKPEN+LLD N +IADFG++++ L TSCGSP+YA PEVI G Y G
Sbjct: 133 HMVVHRDLKPENVLLDAHMNAKIADFGLSNMMSDGEFLRTSCGSPNYAAPEVISGRLYAG 192
Query: 195 RKADVWSCGVILFALLVGALPFDDDNLRQLLEKVKRGVFHMPHFIPPDCQSLLRGMIEVD 254
+ D+WSCGVIL+ALL G LPFDD+++ L +K++ GVF++P ++ +LL M++VD
Sbjct: 193 PEVDIWSCGVILYALLCGTLPFDDEHVPTLFKKIRGGVFYIPEYLNRSVATLLMHMLQVD 252
Query: 255 AARRLTLEHIQKHIWYIGGKNEPEPEQPIPRKVQIRSLPSLEDIDPDVLDS------MHS 308
+R T++ I++H W+ +Q +P + P D +V+D
Sbjct: 253 PLKRATIKDIREHEWF---------KQDLPSYL----FPEDPSYDANVIDDEAVKEVCEK 299
Query: 309 LGCFRDRNKLLQDLLS-EEENQEKMIYFLLLDRKERYPSQEDE----DLPPRNEIDPPRK 363
C ++++ L S + ++Q + Y L++D + R +Q E PP
Sbjct: 300 FEC--TESEVMNSLYSGDPQDQLAVAYHLIIDNR-RIMNQASEFYLASSPPSGSFMDDSA 356
Query: 364 RVDSPMLNRHGKRRP 378
P L H +R P
Sbjct: 357 MHIPPGLKPHPERMP 371
>gi|94557299 protein kinase, AMP-activated, alpha 1 catalytic
subunit isoform 2 [Homo sapiens]
Length = 574
Score = 266 bits (679), Expect = 6e-71
Identities = 155/383 (40%), Positives = 220/383 (57%), Gaps = 35/383 (9%)
Query: 16 VGPYRLEKTLGKGQTGLVKLGVHCVTCQKVAIKIVNREKL-SESVLMKVEREIAILKLIE 74
+G Y L TLG G G VK+G H +T KVA+KI+NR+K+ S V+ K+ REI LKL
Sbjct: 24 IGHYILGDTLGVGTFGKVKVGKHELTGHKVAVKILNRQKIRSLDVVGKIRREIQNLKLFR 83
Query: 75 HPHVLKLHDVYENKKYLYLVLEHVSGGELFDYLVKKGR---------------LTPKEAR 119
HPH++KL+ V +++V+E+VSGGELFDY+ K GR L KE+R
Sbjct: 84 HPHIIKLYQVISTPSDIFMVMEYVSGGELFDYICKNGRKSDVPGVVKTGSTKELDEKESR 143
Query: 120 KFFRQIISALDFCHSHSICHRDLKPENLLLDEKNNIRIADFGMASLQVGDSLLETSCGSP 179
+ F+QI+S +D+CH H + HRDLKPEN+LLD N +IADFG++++ L TSCGSP
Sbjct: 144 RLFQQILSGVDYCHRHMVVHRDLKPENVLLDAHMNAKIADFGLSNMMSDGEFLRTSCGSP 203
Query: 180 HYACPEVIRGEKYDGRKADVWSCGVILFALLVGALPFDDDNLRQLLEKVKRGVFHMPHFI 239
+YA PEVI G Y G + D+WS GVIL+ALL G LPFDDD++ L +K+ G+F+ P ++
Sbjct: 204 NYAAPEVISGRLYAGPEVDIWSSGVILYALLCGTLPFDDDHVPTLFKKICDGIFYTPQYL 263
Query: 240 PPDCQSLLRGMIEVDAARRLTLEHIQKHIWYIGGKNEPE---PEQPIPRKVQIRSLPSLE 296
P SLL+ M++VD +R T++ I++H W+ ++ P+ PE P I E
Sbjct: 264 NPSVISLLKHMLQVDPMKRATIKDIREHEWF--KQDLPKYLFPEDPSYSSTMIDDEALKE 321
Query: 297 DIDPDVLDSMHSLGCFRDRNKLLQDLLSEEENQEKMIYFLLLDRKERYPSQEDEDLPPRN 356
+ L C +RN QD L+ + Y L++D + +D L
Sbjct: 322 VCEKFECSEEEVLSCLYNRNH--QDPLA-------VAYHLIIDNRRIMNEAKDFYL---- 368
Query: 357 EIDPPRKRVDSPMLNR-HGKRRP 378
PP +D L R H +R P
Sbjct: 369 ATSPPDSFLDDHHLTRPHPERVP 391
>gi|7661974 maternal embryonic leucine zipper kinase [Homo sapiens]
Length = 651
Score = 229 bits (583), Expect = 8e-60
Identities = 127/330 (38%), Positives = 199/330 (60%), Gaps = 19/330 (5%)
Query: 19 YRLEKTLGKGQTGLVKLGVHCVTCQKVAIKIVNREKLSESVLMKVEREIAILKLIEHPHV 78
Y L +T+G G VKL H +T + VAIKI+++ L S L +++ EI LK + H H+
Sbjct: 11 YELHETIGTGGFAKVKLACHILTGEMVAIKIMDKNTLG-SDLPRIKTEIEALKNLRHQHI 69
Query: 79 LKLHDVYENKKYLYLVLEHVSGGELFDYLVKKGRLTPKEARKFFRQIISALDFCHSHSIC 138
+L+ V E +++VLE+ GGELFDY++ + RL+ +E R FRQI+SA+ + HS
Sbjct: 70 CQLYHVLETANKIFMVLEYCPGGELFDYIISQDRLSEEETRVVFRQIVSAVAYVHSQGYA 129
Query: 139 HRDLKPENLLLDEKNNIRIADFGMASLQVG--DSLLETSCGSPHYACPEVIRGEKYDGRK 196
HRDLKPENLL DE + +++ DFG+ + G D L+T CGS YA PE+I+G+ Y G +
Sbjct: 130 HRDLKPENLLFDEYHKLKLIDFGLCAKPKGNKDYHLQTCCGSLAYAAPELIQGKSYLGSE 189
Query: 197 ADVWSCGVILFALLVGALPFDDDNLRQLLEKVKRGVFHMPHFIPPDCQSLLRGMIEVDAA 256
ADVWS G++L+ L+ G LPFDDDN+ L +K+ RG + +P ++ P LL+ M++VD
Sbjct: 190 ADVWSMGILLYVLMCGFLPFDDDNVMALYKKIMRGKYDVPKWLSPSSILLLQQMLQVDPK 249
Query: 257 RRLTLEHIQKHIWYIGGKNEPEPEQPIPRKVQIRSLPSLEDIDPDVLD--SMHSLGCFRD 314
+R++++++ H W + N P V+ +S +D D + S+H R+
Sbjct: 250 KRISMKNLLNHPWIMQDYNYP---------VEWQSKNPFIHLDDDCVTELSVH----HRN 296
Query: 315 RNKLLQDLLS-EEENQEKMIYFLLLDRKER 343
+ ++DL+S + + Y LLL +K R
Sbjct: 297 NRQTMEDLISLWQYDHLTATYLLLLAKKAR 326
>gi|7662170 AMPK-related protein kinase 5 [Homo sapiens]
Length = 661
Score = 225 bits (573), Expect = 1e-58
Identities = 105/252 (41%), Positives = 166/252 (65%), Gaps = 2/252 (0%)
Query: 19 YRLEKTLGKGQTGLVKLGVHCVTCQKVAIKIVNREKLS-ESVLMKVEREIAILKLIEHPH 77
Y L++TLGKG G VK + + VAIK + ++K+ E ++ + REI I+ + HPH
Sbjct: 55 YELQETLGKGTYGKVKRATERFSGRVVAIKSIRKDKIKDEQDMVHIRREIEIMSSLNHPH 114
Query: 78 VLKLHDVYENKKYLYLVLEHVSGGELFDYLVKKGRLTPKEARKFFRQIISALDFCHSHSI 137
++ +++V+ENK + +++E+ S GEL+DY+ ++ RL+ +E R FFRQI+SA+ +CH + +
Sbjct: 115 IISIYEVFENKDKIVIIMEYASKGELYDYISERRRLSERETRHFFRQIVSAVHYCHKNGV 174
Query: 138 CHRDLKPENLLLDEKNNIRIADFGMASLQVGDSLLETSCGSPHYACPEVIRGEKYDGRKA 197
HRDLK EN+LLD+ NI+IADFG+++L D L+T CGSP YA PE++ G Y G +
Sbjct: 175 VHRDLKLENILLDDNCNIKIADFGLSNLYQKDKFLQTFCGSPLYASPEIVNGRPYRGPEV 234
Query: 198 DVWSCGVILFALLVGALPFDDDNLRQLLEKVKRGVFHMPHFIPPDCQSLLRGMIEVDAAR 257
D W+ GV+L+ L+ G +PFD + + L+ ++ G + P P D + L+R M+ V+ R
Sbjct: 235 DSWALGVLLYTLVYGTMPFDGFDHKNLIRQISSGEYREP-TQPSDARGLIRWMLMVNPDR 293
Query: 258 RLTLEHIQKHIW 269
R T+E I H W
Sbjct: 294 RATIEDIANHWW 305
>gi|13569922 NUAK family, SNF1-like kinase, 2 [Homo sapiens]
Length = 628
Score = 218 bits (556), Expect = 1e-56
Identities = 142/450 (31%), Positives = 229/450 (50%), Gaps = 38/450 (8%)
Query: 19 YRLEKTLGKGQTGLVKLGVHCVTCQKVAIKIVNREKLS-ESVLMKVEREIAILKLIEHPH 77
Y +TLGKG G VK + + VAIK + ++K+ E LM + REI I+ + HPH
Sbjct: 53 YEFLETLGKGTYGKVKKARES-SGRLVAIKSIRKDKIKDEQDLMHIRREIEIMSSLNHPH 111
Query: 78 VLKLHDVYENKKYLYLVLEHVSGGELFDYLVKKGRLTPKEARKFFRQIISALDFCHSHSI 137
++ +H+V+EN + +V+E+ S G+L+DY+ ++ +L+ +EAR FFRQI+SA+ +CH + +
Sbjct: 112 IIAIHEVFENSSKIVIVMEYASRGDLYDYISERQQLSEREARHFFRQIVSAVHYCHQNRV 171
Query: 138 CHRDLKPENLLLDEKNNIRIADFGMASLQVGDSLLETSCGSPHYACPEVIRGEKYDGRKA 197
HRDLK EN+LLD NI+IADFG+++L L+T CGSP YA PE++ G+ Y G +
Sbjct: 172 VHRDLKLENILLDANGNIKIADFGLSNLYHQGKFLQTFCGSPLYASPEIVNGKPYTGPEV 231
Query: 198 DVWSCGVILFALLVGALPFDDDNLRQLLEKVKRGVFHMPHFIPPDCQSLLRGMIEVDAAR 257
D WS GV+L+ L+ G +PFD + + L++++ G + P P D L+R ++ V+ R
Sbjct: 232 DSWSLGVLLYILVHGTMPFDGHDHKILVKQISNGAYREPP-KPSDACGLIRWLLMVNPTR 290
Query: 258 RLTLEHIQKHIWYIGGKNEPEPEQPIPRKVQIRSLPSLEDIDPDVLDSMHSLGCFRDRNK 317
R TLE + H W G EQ P + P + + D + R
Sbjct: 291 RATLEDVASHWWVNWGYATRVGEQEAPHE---GGHPGSDSARASMADWLR-----RSSRP 342
Query: 318 LLQDLLSEEENQEKMIYFLLLDRKERYPSQEDEDLPPRNEIDPPRKRVDSPMLNRHGKRR 377
LL EN K+ F + P P +R S L + K
Sbjct: 343 LL-------ENGAKVCSFF------------KQHAPGGGSTTPGLERQHS--LKKSRKEN 381
Query: 378 PERKSMEVLSVTDGGSPVPARRAIEMAQHGQRSRSISGASSGLSTSPLSSPRVTPHPSPR 437
+S+ D + P + +++ + G + +S ++ G+ P P ++P P+
Sbjct: 382 DMAQSLH-SDTADDTAHRPGKSNLKLPK-GILKKKVSASAEGVQEDP---PELSPIPASP 436
Query: 438 GSPLP-TPKGTPVHTPKESPAGTPNPTPPS 466
G P PK + P++ +G + PS
Sbjct: 437 GQAAPLLPKKGILKKPRQRESGYYSSPEPS 466
>gi|156105707 SNF related kinase [Homo sapiens]
Length = 765
Score = 217 bits (553), Expect = 2e-56
Identities = 132/441 (29%), Positives = 228/441 (51%), Gaps = 27/441 (6%)
Query: 17 GPYRLEKTLGKGQTGLVKLGVHCVTCQKVAIKIVNREKLSESVLMKVEREIAILKLIEHP 76
G Y L+KTLG+G +VKL H T +KVA+K++++ KL + +E+ +KL++HP
Sbjct: 14 GLYDLDKTLGRGHFAVVKLARHVFTGEKVAVKVIDKTKLDTLATGHLFQEVRCMKLVQHP 73
Query: 77 HVLKLHDVYENKKYLYLVLEHVSGGELFDYLVKKGR-LTPKEARKFFRQIISALDFCHSH 135
++++L++V + + LYL+LE GG++FDY++K L A+K+F QI+ A+ +CH
Sbjct: 74 NIVRLYEVIDTQTKLYLILELGDGGDMFDYIMKHEEGLNEDLAKKYFAQIVHAISYCHKL 133
Query: 136 SICHRDLKPENLLLDEKNN-IRIADFGMASLQVGDSLLETSCGSPHYACPEVIRGEKYDG 194
+ HRDLKPEN++ EK +++ DFG ++ L TSCGS Y+ PE++ G++YD
Sbjct: 134 HVVHRDLKPENVVFFEKQGLVKLTDFGFSNKFQPGKKLTTSCGSLAYSAPEILLGDEYDA 193
Query: 195 RKADVWSCGVILFALLVGALPFDDDNLRQLLEKVKRGVFHMPHFIPPDCQSLLRGMIEVD 254
D+WS GVILF L+ G PF + N + L + + +P + +C+ L+ M++ D
Sbjct: 194 PAVDIWSLGVILFMLVCGQPPFQEANDSETLTMIMDCKYTVPSHVSKECKDLITRMLQRD 253
Query: 255 AARRLTLEHIQKHIWYIGGKNEPEPEQPIPRKVQIRSLPSLEDIDPDVLDSMHSLGCFRD 314
RR +LE I+ H W G P + IP + S +L + + + + LG D
Sbjct: 254 PKRRASLEEIENHPWLQGVDPSPATKYNIP----LVSYKNLSEEEHNSIIQRMVLGDIAD 309
Query: 315 RNKLLQDLLSEEENQEKMIYFLLLDRKERYPSQEDEDLPPRNEIDPPRK---------RV 365
R+ +++ L + N YFLL +R R ++++++ R+ K ++
Sbjct: 310 RDAIVEALETNRYNHITATYFLLAERILR--EKQEKEIQTRSASPSNIKAQFRQSWPTKI 367
Query: 366 DSPMLNRHGKRRPERKSMEVLSVTDGGSPVPARRAIEMAQHGQRSRSISGASSGLSTSPL 425
D P + + ++ P RA + +G RS+ + ++ L
Sbjct: 368 DVP--------QDLEDDLTATPLSHATVPQSPARAADSVLNGHRSKGLCDSAKKDDLPEL 419
Query: 426 SSPRVTPHPSPRGSPLPTPKG 446
+ P ++ P S PT G
Sbjct: 420 AGPALS--TVPPASLKPTASG 438
>gi|156105705 SNF related kinase [Homo sapiens]
Length = 765
Score = 217 bits (553), Expect = 2e-56
Identities = 132/441 (29%), Positives = 228/441 (51%), Gaps = 27/441 (6%)
Query: 17 GPYRLEKTLGKGQTGLVKLGVHCVTCQKVAIKIVNREKLSESVLMKVEREIAILKLIEHP 76
G Y L+KTLG+G +VKL H T +KVA+K++++ KL + +E+ +KL++HP
Sbjct: 14 GLYDLDKTLGRGHFAVVKLARHVFTGEKVAVKVIDKTKLDTLATGHLFQEVRCMKLVQHP 73
Query: 77 HVLKLHDVYENKKYLYLVLEHVSGGELFDYLVKKGR-LTPKEARKFFRQIISALDFCHSH 135
++++L++V + + LYL+LE GG++FDY++K L A+K+F QI+ A+ +CH
Sbjct: 74 NIVRLYEVIDTQTKLYLILELGDGGDMFDYIMKHEEGLNEDLAKKYFAQIVHAISYCHKL 133
Query: 136 SICHRDLKPENLLLDEKNN-IRIADFGMASLQVGDSLLETSCGSPHYACPEVIRGEKYDG 194
+ HRDLKPEN++ EK +++ DFG ++ L TSCGS Y+ PE++ G++YD
Sbjct: 134 HVVHRDLKPENVVFFEKQGLVKLTDFGFSNKFQPGKKLTTSCGSLAYSAPEILLGDEYDA 193
Query: 195 RKADVWSCGVILFALLVGALPFDDDNLRQLLEKVKRGVFHMPHFIPPDCQSLLRGMIEVD 254
D+WS GVILF L+ G PF + N + L + + +P + +C+ L+ M++ D
Sbjct: 194 PAVDIWSLGVILFMLVCGQPPFQEANDSETLTMIMDCKYTVPSHVSKECKDLITRMLQRD 253
Query: 255 AARRLTLEHIQKHIWYIGGKNEPEPEQPIPRKVQIRSLPSLEDIDPDVLDSMHSLGCFRD 314
RR +LE I+ H W G P + IP + S +L + + + + LG D
Sbjct: 254 PKRRASLEEIENHPWLQGVDPSPATKYNIP----LVSYKNLSEEEHNSIIQRMVLGDIAD 309
Query: 315 RNKLLQDLLSEEENQEKMIYFLLLDRKERYPSQEDEDLPPRNEIDPPRK---------RV 365
R+ +++ L + N YFLL +R R ++++++ R+ K ++
Sbjct: 310 RDAIVEALETNRYNHITATYFLLAERILR--EKQEKEIQTRSASPSNIKAQFRQSWPTKI 367
Query: 366 DSPMLNRHGKRRPERKSMEVLSVTDGGSPVPARRAIEMAQHGQRSRSISGASSGLSTSPL 425
D P + + ++ P RA + +G RS+ + ++ L
Sbjct: 368 DVP--------QDLEDDLTATPLSHATVPQSPARAADSVLNGHRSKGLCDSAKKDDLPEL 419
Query: 426 SSPRVTPHPSPRGSPLPTPKG 446
+ P ++ P S PT G
Sbjct: 420 AGPALS--TVPPASLKPTASG 438
>gi|23503303 serine/threonine-protein kinase NIM1 [Homo sapiens]
Length = 436
Score = 198 bits (503), Expect = 2e-50
Identities = 105/336 (31%), Positives = 186/336 (55%), Gaps = 8/336 (2%)
Query: 16 VGPYRLEKTLGKGQTGLVKLGVHCVTCQKVAIKIVNREKLSESVLMKVEREIAILKLIEH 75
+G YR+ +G G VKLG+H +T +KVAIKI+++ KL + + REI+ ++ + H
Sbjct: 71 IGFYRIRGEIGSGNFSQVKLGIHSLTKEKVAIKILDKTKLDQKTQRLLSREISSMEKLHH 130
Query: 76 PHVLKLHDVYENKKYLYLVLEHVSGGELFDYLVKKGRLTPKEARKFFRQIISALDFCHSH 135
P++++L++V E L+LV+E+ GGELF + +G+L+ E++ F QI+SA+ H +
Sbjct: 131 PNIIRLYEVVETLSKLHLVMEYAGGGELFGKISTEGKLSEPESKLIFSQIVSAVKHMHEN 190
Query: 136 SICHRDLKPENLLLDEKNNIRIADFGMASLQVGDSLLETSCGSPHYACPEVIRGEKYDGR 195
I HRDLK EN+ +++ DFG +++ +L T CGSP YA PE+ R E Y G
Sbjct: 191 QIIHRDLKAENVFYTSNTCVKVGDFGFSTVSKKGEMLNTFCGSPPYAAPELFRDEHYIGI 250
Query: 196 KADVWSCGVILFALLVGALPFDDDNLRQLLEKVKRGVFHMPHFIPPDCQSLLRGMIEVDA 255
D+W+ GV+L+ ++ G +PF + + +L + + G + +P + C L+RG+++
Sbjct: 251 YVDIWALGVLLYFMVTGTMPFRAETVAKLKKSILEGTYSVPPHVSEPCHRLIRGVLQQIP 310
Query: 256 ARRLTLEHIQKHIWYIGGKNEPEPEQPIPRKVQ-IRSLPSLEDIDPDVLDSMHSLGCFRD 314
R ++ I W + G P P +P + + +L++ + +V ++ LG +
Sbjct: 311 TERYGIDCIMNDEW-MQGVPYPTPLEPFQLDPKHLSETSTLKEEENEVKSTLEHLGITEE 369
Query: 315 --RNKLLQDLLSEEENQEKMIYFLLLDRKERYPSQE 348
RN +D S +Y ++L R +R + E
Sbjct: 370 HIRNNQGRDARSSITG----VYRIILHRVQRKKALE 401
>gi|7657214 hormonally upregulated Neu-associated kinase [Homo
sapiens]
Length = 714
Score = 191 bits (485), Expect = 2e-48
Identities = 125/349 (35%), Positives = 195/349 (55%), Gaps = 16/349 (4%)
Query: 11 QHAQYVGPYRL-EKTLGKGQTGLVKLGVHCVTCQKVAIKIVNREKLSES--VLMKVEREI 67
QH + VG Y + + LG+G V+ G+H +T +KVAIK++++++ + V + RE
Sbjct: 53 QHHKRVGNYLIGSRKLGEGSFAKVREGLHVLTGEKVAIKVIDKKRAKKDTYVTKNLRREG 112
Query: 68 AILKLIEHPHVLKLHDVYENKKYLYLVLEHVSGGELFDYLVKKGRLTPKEARKFFRQIIS 127
I ++I HP++ +L D+ E + YLV+E GG L + +K RL EAR++ RQ+IS
Sbjct: 113 QIQQMIRHPNITQLLDILETENSYYLVMELCPGGNLMHKIYEKKRLEESEARRYIRQLIS 172
Query: 128 ALDFCHSHSICHRDLKPENLLLDEKNNIRIADFGM---ASLQVGDSLLETSCGSPHYACP 184
A++ H + HRDLK ENLLLDE NNI++ DFG+ A + T CGSP YA P
Sbjct: 173 AVEHLHRAGVVHRDLKIENLLLDEDNNIKLIDFGLSNCAGILGYSDPFSTQCGSPAYAAP 232
Query: 185 EVIRGEKYDGRKADVWSCGVILFALLVGALPF--DDDNLRQLLEK-VKRGVFHMPHFIPP 241
E++ +KY G K DVWS GV ++A+L G LPF + +LR L +K V + + +P +
Sbjct: 233 ELLARKKY-GPKIDVWSIGVNMYAMLTGTLPFTVEPFSLRALYQKMVDKEMNPLPTQLST 291
Query: 242 DCQSLLRGMIEVDAARRLTLEHIQKHIWYIGGKNEPEPEQPIPRKVQIRSLPSLEDIDPD 301
S LR ++E D +R ++ + W NE + +P V + SLED+ P
Sbjct: 292 GAISFLRSLLEPDPVKRPNIQQALANRWL----NENYTGK-VPCNVTYPNRISLEDLSPS 346
Query: 302 VLDSMHSLGCFRDRNKLLQDLLSEEENQEKMIYFLLLDRKERYPSQEDE 350
V+ M +++ + ++ +LS IYFLL + ERY S + +
Sbjct: 347 VVLHMTEKLGYKN-SDVINTVLSNRACHILAIYFLLNKKLERYLSGKSD 394
>gi|212549756 calcium/calmodulin-dependent protein kinase II delta
isoform 4 [Homo sapiens]
Length = 489
Score = 183 bits (464), Expect = 5e-46
Identities = 98/264 (37%), Positives = 159/264 (60%), Gaps = 9/264 (3%)
Query: 14 QYVGPYRLEKTLGKGQTGLVKLGVHCVTCQKVAIKIVNREKLSESVLMKVEREIAILKLI 73
++ Y+L + LGKG +V+ + T Q+ A KI+N +KLS K+ERE I +L+
Sbjct: 9 RFTDEYQLFEELGKGAFSVVRRCMKIPTGQEYAAKIINTKKLSARDHQKLEREARICRLL 68
Query: 74 EHPHVLKLHDVYENKKYLYLVLEHVSGGELFDYLVKKGRLTPKEARKFFRQIISALDFCH 133
+HP++++LHD + + YLV + V+GGELF+ +V + + +A +QI+ +++ CH
Sbjct: 69 KHPNIVRLHDSISEEGFHYLVFDLVTGGELFEDIVAREYYSEADASHCIQQILESVNHCH 128
Query: 134 SHSICHRDLKPENLLLDEKNN---IRIADFGMASLQVGDSLLETS-CGSPHYACPEVIRG 189
+ I HRDLKPENLLL K+ +++ADFG+A GD G+P Y PEV+R
Sbjct: 129 LNGIVHRDLKPENLLLASKSKGAAVKLADFGLAIEVQGDQQAWFGFAGTPGYLSPEVLRK 188
Query: 190 EKYDGRKADVWSCGVILFALLVGALPFDDDNLRQLLEKVKRGVFHMP----HFIPPDCQS 245
+ Y G+ D+W+CGVIL+ LLVG PF D++ +L +++K G + P + P+ +
Sbjct: 189 DPY-GKPVDMWACGVILYILLVGYPPFWDEDQHRLYQQIKAGAYDFPSPEWDTVTPEAKD 247
Query: 246 LLRGMIEVDAARRLTLEHIQKHIW 269
L+ M+ ++ A+R+T KH W
Sbjct: 248 LINKMLTINPAKRITASEALKHPW 271
>gi|26667183 calcium/calmodulin-dependent protein kinase II delta
isoform 1 [Homo sapiens]
Length = 478
Score = 183 bits (464), Expect = 5e-46
Identities = 98/264 (37%), Positives = 159/264 (60%), Gaps = 9/264 (3%)
Query: 14 QYVGPYRLEKTLGKGQTGLVKLGVHCVTCQKVAIKIVNREKLSESVLMKVEREIAILKLI 73
++ Y+L + LGKG +V+ + T Q+ A KI+N +KLS K+ERE I +L+
Sbjct: 9 RFTDEYQLFEELGKGAFSVVRRCMKIPTGQEYAAKIINTKKLSARDHQKLEREARICRLL 68
Query: 74 EHPHVLKLHDVYENKKYLYLVLEHVSGGELFDYLVKKGRLTPKEARKFFRQIISALDFCH 133
+HP++++LHD + + YLV + V+GGELF+ +V + + +A +QI+ +++ CH
Sbjct: 69 KHPNIVRLHDSISEEGFHYLVFDLVTGGELFEDIVAREYYSEADASHCIQQILESVNHCH 128
Query: 134 SHSICHRDLKPENLLLDEKNN---IRIADFGMASLQVGDSLLETS-CGSPHYACPEVIRG 189
+ I HRDLKPENLLL K+ +++ADFG+A GD G+P Y PEV+R
Sbjct: 129 LNGIVHRDLKPENLLLASKSKGAAVKLADFGLAIEVQGDQQAWFGFAGTPGYLSPEVLRK 188
Query: 190 EKYDGRKADVWSCGVILFALLVGALPFDDDNLRQLLEKVKRGVFHMP----HFIPPDCQS 245
+ Y G+ D+W+CGVIL+ LLVG PF D++ +L +++K G + P + P+ +
Sbjct: 189 DPY-GKPVDMWACGVILYILLVGYPPFWDEDQHRLYQQIKAGAYDFPSPEWDTVTPEAKD 247
Query: 246 LLRGMIEVDAARRLTLEHIQKHIW 269
L+ M+ ++ A+R+T KH W
Sbjct: 248 LINKMLTINPAKRITASEALKHPW 271
>gi|212549753 calcium/calmodulin-dependent protein kinase II delta
isoform 5 [Homo sapiens]
Length = 492
Score = 183 bits (464), Expect = 5e-46
Identities = 98/264 (37%), Positives = 159/264 (60%), Gaps = 9/264 (3%)
Query: 14 QYVGPYRLEKTLGKGQTGLVKLGVHCVTCQKVAIKIVNREKLSESVLMKVEREIAILKLI 73
++ Y+L + LGKG +V+ + T Q+ A KI+N +KLS K+ERE I +L+
Sbjct: 9 RFTDEYQLFEELGKGAFSVVRRCMKIPTGQEYAAKIINTKKLSARDHQKLEREARICRLL 68
Query: 74 EHPHVLKLHDVYENKKYLYLVLEHVSGGELFDYLVKKGRLTPKEARKFFRQIISALDFCH 133
+HP++++LHD + + YLV + V+GGELF+ +V + + +A +QI+ +++ CH
Sbjct: 69 KHPNIVRLHDSISEEGFHYLVFDLVTGGELFEDIVAREYYSEADASHCIQQILESVNHCH 128
Query: 134 SHSICHRDLKPENLLLDEKNN---IRIADFGMASLQVGDSLLETS-CGSPHYACPEVIRG 189
+ I HRDLKPENLLL K+ +++ADFG+A GD G+P Y PEV+R
Sbjct: 129 LNGIVHRDLKPENLLLASKSKGAAVKLADFGLAIEVQGDQQAWFGFAGTPGYLSPEVLRK 188
Query: 190 EKYDGRKADVWSCGVILFALLVGALPFDDDNLRQLLEKVKRGVFHMP----HFIPPDCQS 245
+ Y G+ D+W+CGVIL+ LLVG PF D++ +L +++K G + P + P+ +
Sbjct: 189 DPY-GKPVDMWACGVILYILLVGYPPFWDEDQHRLYQQIKAGAYDFPSPEWDTVTPEAKD 247
Query: 246 LLRGMIEVDAARRLTLEHIQKHIW 269
L+ M+ ++ A+R+T KH W
Sbjct: 248 LINKMLTINPAKRITASEALKHPW 271
>gi|26667186 calcium/calmodulin-dependent protein kinase II delta
isoform 1 [Homo sapiens]
Length = 478
Score = 183 bits (464), Expect = 5e-46
Identities = 98/264 (37%), Positives = 159/264 (60%), Gaps = 9/264 (3%)
Query: 14 QYVGPYRLEKTLGKGQTGLVKLGVHCVTCQKVAIKIVNREKLSESVLMKVEREIAILKLI 73
++ Y+L + LGKG +V+ + T Q+ A KI+N +KLS K+ERE I +L+
Sbjct: 9 RFTDEYQLFEELGKGAFSVVRRCMKIPTGQEYAAKIINTKKLSARDHQKLEREARICRLL 68
Query: 74 EHPHVLKLHDVYENKKYLYLVLEHVSGGELFDYLVKKGRLTPKEARKFFRQIISALDFCH 133
+HP++++LHD + + YLV + V+GGELF+ +V + + +A +QI+ +++ CH
Sbjct: 69 KHPNIVRLHDSISEEGFHYLVFDLVTGGELFEDIVAREYYSEADASHCIQQILESVNHCH 128
Query: 134 SHSICHRDLKPENLLLDEKNN---IRIADFGMASLQVGDSLLETS-CGSPHYACPEVIRG 189
+ I HRDLKPENLLL K+ +++ADFG+A GD G+P Y PEV+R
Sbjct: 129 LNGIVHRDLKPENLLLASKSKGAAVKLADFGLAIEVQGDQQAWFGFAGTPGYLSPEVLRK 188
Query: 190 EKYDGRKADVWSCGVILFALLVGALPFDDDNLRQLLEKVKRGVFHMP----HFIPPDCQS 245
+ Y G+ D+W+CGVIL+ LLVG PF D++ +L +++K G + P + P+ +
Sbjct: 189 DPY-GKPVDMWACGVILYILLVGYPPFWDEDQHRLYQQIKAGAYDFPSPEWDTVTPEAKD 247
Query: 246 LLRGMIEVDAARRLTLEHIQKHIW 269
L+ M+ ++ A+R+T KH W
Sbjct: 248 LINKMLTINPAKRITASEALKHPW 271
Database: hs.faa
Posted date: Aug 4, 2009 4:42 PM
Number of letters in database: 18,247,518
Number of sequences in database: 37,866
Lambda K H
0.317 0.135 0.401
Gapped
Lambda K H
0.267 0.0410 0.140
Matrix: BLOSUM62
Gap Penalties: Existence: 11, Extension: 1
Number of Hits to DB: 29,813,392
Number of Sequences: 37866
Number of extensions: 1707734
Number of successful extensions: 19265
Number of sequences better than 10.0: 30
Number of HSP's better than 10.0 without gapping: 920
Number of HSP's successfully gapped in prelim test: 769
Number of HSP's that attempted gapping in prelim test: 10231
Number of HSP's gapped (non-prelim): 6148
length of query: 668
length of database: 18,247,518
effective HSP length: 109
effective length of query: 559
effective length of database: 14,120,124
effective search space: 7893149316
effective search space used: 7893149316
T: 11
A: 40
X1: 16 ( 7.3 bits)
X2: 38 (14.6 bits)
X3: 64 (24.7 bits)
S1: 41 (21.6 bits)
S2: 65 (29.6 bits)
Search results were obtained with NCBI BLAST and RefSeq entries.
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Guide to the Human Genome
Copyright © 2010 by Stewart Scherer. All rights reserved.