BLASTP 2.2.11 [Jun-05-2005] Reference: Altschul, Stephen F., Thomas L. Madden, Alejandro A. Schaffer, Jinghui Zhang, Zheng Zhang, Webb Miller, and David J. Lipman (1997), "Gapped BLAST and PSI-BLAST: a new generation of protein database search programs", Nucleic Acids Res. 25:3389-3402. Query= gi|116063562 FERM domain containing 4A [Homo sapiens] (1039 letters) Database: hs.faa 37,866 sequences; 18,247,518 total letters Searching..................................................done Score E Sequences producing significant alignments: (bits) Value gi|116063562 FERM domain containing 4A [Homo sapiens] 2078 0.0 gi|150010540 FERM domain containing 4B [Homo sapiens] 850 0.0 gi|217035131 hypothetical protein LOC55765 isoform 1 [Homo sapiens] 225 1e-58 gi|217035133 hypothetical protein LOC55765 isoform 2 [Homo sapiens] 225 2e-58 gi|4505257 moesin [Homo sapiens] 152 2e-36 gi|4506467 radixin [Homo sapiens] 150 5e-36 gi|161702986 ezrin [Homo sapiens] 144 6e-34 gi|21614499 ezrin [Homo sapiens] 144 6e-34 gi|32967254 neurofibromin 2 isoform 2 [Homo sapiens] 142 2e-33 gi|32967266 neurofibromin 2 isoform 2 [Homo sapiens] 142 2e-33 gi|32451486 neurofibromin 2 isoform 2 [Homo sapiens] 142 2e-33 gi|4557795 neurofibromin 2 isoform 1 [Homo sapiens] 142 2e-33 gi|15826862 coiled-coil domain containing 120 isoform 3 [Homo sa... 127 5e-29 gi|254039610 coiled-coil domain containing 120 isoform 1 [Homo s... 127 5e-29 gi|254039614 coiled-coil domain containing 120 isoform 4 [Homo s... 125 3e-28 gi|254039612 coiled-coil domain containing 120 isoform 2 [Homo s... 125 3e-28 gi|32967260 neurofibromin 2 isoform 5 [Homo sapiens] 114 4e-25 gi|40254949 erythrocyte membrane protein band 4.1 like 5 [Homo s... 112 2e-24 gi|94721308 FERM domain containing 5 isoform 2 [Homo sapiens] 109 2e-23 gi|30061491 erythrocyte membrane protein band 4.1-like 1 isoform... 106 1e-22 gi|30061489 erythrocyte membrane protein band 4.1-like 1 isoform... 106 1e-22 gi|87042275 erythrocyte protein band 4.1-like 4 [Homo sapiens] 106 1e-22 gi|117500790 FERM domain containing 3 [Homo sapiens] 105 2e-22 gi|34916000 FERM domain containing 7 [Homo sapiens] 102 1e-21 gi|5031633 FERM, RhoGEF, and pleckstrin domain protein 1 isoform... 100 7e-21 gi|32967262 neurofibromin 2 isoform 6 [Homo sapiens] 100 7e-21 gi|7662310 FERM, RhoGEF and pleckstrin domain protein 2 [Homo sa... 99 3e-20 gi|150418005 protein tyrosine phosphatase, non-receptor type 21 ... 98 4e-20 gi|32490572 erythrocyte membrane protein band 4.1-like 3 [Homo s... 97 8e-20 gi|110624794 erythrocyte membrane protein band 4.1 like 4B isofo... 97 8e-20 >gi|116063562 FERM domain containing 4A [Homo sapiens] Length = 1039 Score = 2078 bits (5385), Expect = 0.0 Identities = 1039/1039 (100%), Positives = 1039/1039 (100%) Query: 1 MAVQLVPDSALGLLMMTEGRRCQVHLLDDRKLELLVQPKLLAKELLDLVASHFNLKEKEY 60 MAVQLVPDSALGLLMMTEGRRCQVHLLDDRKLELLVQPKLLAKELLDLVASHFNLKEKEY Sbjct: 1 MAVQLVPDSALGLLMMTEGRRCQVHLLDDRKLELLVQPKLLAKELLDLVASHFNLKEKEY 60 Query: 61 FGIAFTDETGHLNWLQLDRRVLEHDFPKKSGPVVLYFCVRFYIESISYLKDNATIELFFL 120 FGIAFTDETGHLNWLQLDRRVLEHDFPKKSGPVVLYFCVRFYIESISYLKDNATIELFFL Sbjct: 61 FGIAFTDETGHLNWLQLDRRVLEHDFPKKSGPVVLYFCVRFYIESISYLKDNATIELFFL 120 Query: 121 NAKSCIYKELIDVDSEVVFELASYILQEAKGDFSSNEVVRSDLKKLPALPTQALKEHPSL 180 NAKSCIYKELIDVDSEVVFELASYILQEAKGDFSSNEVVRSDLKKLPALPTQALKEHPSL Sbjct: 121 NAKSCIYKELIDVDSEVVFELASYILQEAKGDFSSNEVVRSDLKKLPALPTQALKEHPSL 180 Query: 181 AYCEDRVIEHYKKLNGQTRGQAIVNYMSIVESLPTYGVHYYAVKDKQGIPWWLGLSYKGI 240 AYCEDRVIEHYKKLNGQTRGQAIVNYMSIVESLPTYGVHYYAVKDKQGIPWWLGLSYKGI Sbjct: 181 AYCEDRVIEHYKKLNGQTRGQAIVNYMSIVESLPTYGVHYYAVKDKQGIPWWLGLSYKGI 240 Query: 241 FQYDYHDKVKPRKIFQWRQLENLYFREKKFSVEVHDPRRASVTRRTFGHSGIAVHTWYAC 300 FQYDYHDKVKPRKIFQWRQLENLYFREKKFSVEVHDPRRASVTRRTFGHSGIAVHTWYAC Sbjct: 241 FQYDYHDKVKPRKIFQWRQLENLYFREKKFSVEVHDPRRASVTRRTFGHSGIAVHTWYAC 300 Query: 301 PALIKSIWAMAISQHQFYLDRKQSKSKIHAARSLSEIAIDLTETGTLKTSKLANMGSKGK 360 PALIKSIWAMAISQHQFYLDRKQSKSKIHAARSLSEIAIDLTETGTLKTSKLANMGSKGK Sbjct: 301 PALIKSIWAMAISQHQFYLDRKQSKSKIHAARSLSEIAIDLTETGTLKTSKLANMGSKGK 360 Query: 361 IISGSSGSLLSSGSQESDSSQSAKKDMLAALKSRQEALEETLRQRLEELKKLCLREAELT 420 IISGSSGSLLSSGSQESDSSQSAKKDMLAALKSRQEALEETLRQRLEELKKLCLREAELT Sbjct: 361 IISGSSGSLLSSGSQESDSSQSAKKDMLAALKSRQEALEETLRQRLEELKKLCLREAELT 420 Query: 421 GKLPVEYPLDPGEEPPIVRRRIGTAFKLDEQKILPKGEEAELERLEREFAIQSQITEAAR 480 GKLPVEYPLDPGEEPPIVRRRIGTAFKLDEQKILPKGEEAELERLEREFAIQSQITEAAR Sbjct: 421 GKLPVEYPLDPGEEPPIVRRRIGTAFKLDEQKILPKGEEAELERLEREFAIQSQITEAAR 480 Query: 481 RLASDPNVSKKLKKQRKTSYLNALKKLQEIENAINENRIKSGKKPTQRASLIIDDGNIAS 540 RLASDPNVSKKLKKQRKTSYLNALKKLQEIENAINENRIKSGKKPTQRASLIIDDGNIAS Sbjct: 481 RLASDPNVSKKLKKQRKTSYLNALKKLQEIENAINENRIKSGKKPTQRASLIIDDGNIAS 540 Query: 541 EDSSLSDALVLEDEDSQVTSTISPLHSPHKGLPPRPPSHNRPPPPQSLEGLRQMHYHRND 600 EDSSLSDALVLEDEDSQVTSTISPLHSPHKGLPPRPPSHNRPPPPQSLEGLRQMHYHRND Sbjct: 541 EDSSLSDALVLEDEDSQVTSTISPLHSPHKGLPPRPPSHNRPPPPQSLEGLRQMHYHRND 600 Query: 601 YDKSPIKPKMWSESSLDEPYEKVKKRSSHSHSSSHKRFPSTGSCAEAGGGSNSLQNSPIR 660 YDKSPIKPKMWSESSLDEPYEKVKKRSSHSHSSSHKRFPSTGSCAEAGGGSNSLQNSPIR Sbjct: 601 YDKSPIKPKMWSESSLDEPYEKVKKRSSHSHSSSHKRFPSTGSCAEAGGGSNSLQNSPIR 660 Query: 661 GLPHWNSQSSMPSTPDLRVRSPHYVHSTRSVDISPTRLHSLALHFRHRSSSLESQGKLLG 720 GLPHWNSQSSMPSTPDLRVRSPHYVHSTRSVDISPTRLHSLALHFRHRSSSLESQGKLLG Sbjct: 661 GLPHWNSQSSMPSTPDLRVRSPHYVHSTRSVDISPTRLHSLALHFRHRSSSLESQGKLLG 720 Query: 721 SENDTGSPDFYTPRTRSSNGSDPMDDCSSCTSHSSSEHYYPAQMNANYSTLAEDSPSKAR 780 SENDTGSPDFYTPRTRSSNGSDPMDDCSSCTSHSSSEHYYPAQMNANYSTLAEDSPSKAR Sbjct: 721 SENDTGSPDFYTPRTRSSNGSDPMDDCSSCTSHSSSEHYYPAQMNANYSTLAEDSPSKAR 780 Query: 781 QRQRQRQRAAGALGSASSGSMPNLAARGGAGGAGGAGGGVYLHSQSQPSSQYRIKEYPLY 840 QRQRQRQRAAGALGSASSGSMPNLAARGGAGGAGGAGGGVYLHSQSQPSSQYRIKEYPLY Sbjct: 781 QRQRQRQRAAGALGSASSGSMPNLAARGGAGGAGGAGGGVYLHSQSQPSSQYRIKEYPLY 840 Query: 841 IEGGATPVVVRSLESDQEGHYSVKAQFKTSNSYTAGGLFKESWRGGGGDEGDTGRLTPSR 900 IEGGATPVVVRSLESDQEGHYSVKAQFKTSNSYTAGGLFKESWRGGGGDEGDTGRLTPSR Sbjct: 841 IEGGATPVVVRSLESDQEGHYSVKAQFKTSNSYTAGGLFKESWRGGGGDEGDTGRLTPSR 900 Query: 901 SQILRTPSLGREGAHDKGAGRAAVSDELRQWYQRSTASHKEHSRLSHTSSTSSDSGSQYS 960 SQILRTPSLGREGAHDKGAGRAAVSDELRQWYQRSTASHKEHSRLSHTSSTSSDSGSQYS Sbjct: 901 SQILRTPSLGREGAHDKGAGRAAVSDELRQWYQRSTASHKEHSRLSHTSSTSSDSGSQYS 960 Query: 961 TSSQSTFVAHSRVTRMPQMCKATSAALPQSQRSSTPSSEIGATPPSSPHHILTWQTGEAT 1020 TSSQSTFVAHSRVTRMPQMCKATSAALPQSQRSSTPSSEIGATPPSSPHHILTWQTGEAT Sbjct: 961 TSSQSTFVAHSRVTRMPQMCKATSAALPQSQRSSTPSSEIGATPPSSPHHILTWQTGEAT 1020 Query: 1021 ENSPILDGSESPPHQSTDE 1039 ENSPILDGSESPPHQSTDE Sbjct: 1021 ENSPILDGSESPPHQSTDE 1039 >gi|150010540 FERM domain containing 4B [Homo sapiens] Length = 1034 Score = 850 bits (2197), Expect = 0.0 Identities = 496/1009 (49%), Positives = 640/1009 (63%), Gaps = 101/1009 (10%) Query: 16 MTEGRRCQVHLLDDRKLELLVQPKLLAKELLDLVASHFNLKEKEYFGIAFTDETGHLNWL 75 MTEGR CQVHLLDDR+LELLVQPKLLA+ELLDLVASHFNLKEKEYFGI F D+TG NWL Sbjct: 55 MTEGRHCQVHLLDDRRLELLVQPKLLARELLDLVASHFNLKEKEYFGITFIDDTGQQNWL 114 Query: 76 QLDRRVLEHDFPKKSGPVVLYFCVRFYIESISYLKDNATIELFFLNAKSCIYKELIDVDS 135 QLD RVL+HD PKK GP +L+F VRFYIESIS+LKD T+ELFFLNAK+C++K I+V+S Sbjct: 115 QLDHRVLDHDLPKKPGPTILHFAVRFYIESISFLKDKTTVELFFLNAKACVHKGQIEVES 174 Query: 136 EVVFELASYILQEAKGDFSSNEVVRSDLKKLPALPTQALKEHPSLAYCEDRVIEHYKKLN 195 E +F+LA++ILQEAKGD++S+E R DLK LPA PT+ L+EHPSLAYCEDRVIEHY K+ Sbjct: 175 ETIFKLAAFILQEAKGDYTSDENARKDLKTLPAFPTKTLQEHPSLAYCEDRVIEHYLKIK 234 Query: 196 GQTRGQAIVNYMSIVESLPTYGVHYYAVKDKQGIPWWLGLSYKGIFQYDYHDKVKPRKIF 255 G TRGQA+V YM IVE+LPTYGVHYYAVKDKQG+PWWLG+SYKGI QYD DKVKPRK+F Sbjct: 235 GLTRGQAVVQYMKIVEALPTYGVHYYAVKDKQGLPWWLGISYKGIGQYDIQDKVKPRKLF 294 Query: 256 QWRQLENLYFREKKFSVEVHDPRRASVTRRTFGHSGIAVHTWYACPALIKSIWAMAISQH 315 QW+QLENLYFREKKF+VEVHDPRR SV+RRTFG SG+ V TWYA +LIKSIW MAISQH Sbjct: 295 QWKQLENLYFREKKFAVEVHDPRRISVSRRTFGQSGLFVQTWYANSSLIKSIWVMAISQH 354 Query: 316 QFYLDRKQSKSKIHAARSLSEIAIDLTETGTLKTSKLANMGSKGKIISGSSGSLLSSGSQ 375 QFYLDRKQSK+KI +ARSL EIA+DLTETGT + SKL + +K + I S+GSL+SSGSQ Sbjct: 355 QFYLDRKQSKAKIPSARSLDEIAMDLTETGTQRASKLVTLEAKSQFIMASNGSLISSGSQ 414 Query: 376 ESDSSQSAKKDMLAALKSRQEALEETLRQRLEELKKLCLREAELTGKLPVEYPLDPGEEP 435 +S+ S+ K++ + LK +++ L+E L +++EELKK+CLREAELTGK+P EYPL+ GE+P Sbjct: 415 DSEVSEEQKREKILELKKKEKLLQEKLLKKVEELKKICLREAELTGKMPKEYPLNIGEKP 474 Query: 436 PIVRRRIGTAFKLDEQKILPKGEEAELERLEREFAIQSQITEAARRLASDPNVSKKLKKQ 495 P VRRR+GTAFKLD+ +LP E+ L+ LE F IQ ++ EAA++LA++P++ K +KK+ Sbjct: 475 PQVRRRVGTAFKLDD-NLLPSEEDPALQELESNFLIQQKLVEAAKKLANEPDLCKTVKKK 533 Query: 496 RKTSYLNALKKLQEIENAINENRIKSGKKPTQRASLIIDDGNIASEDSSLSDALVLEDED 555 RK Y +A+KKLQEIENAINE RI+ GKKP+Q+A+++ +D I SE SSLSD +D Sbjct: 534 RKQDYTDAMKKLQEIENAINEYRIRCGKKPSQKATVLPED-IIPSESSSLSDTTTYDDPS 592 Query: 556 SQVT----STISPLHSPHKGLPPRPPSHNRPPPPQSLEGLRQMHYHRNDYDKSPIKPKMW 611 T + S HSP R PP+SL G+ ++H+ + Sbjct: 593 DAFTFPGQRSSSVPHSP------------RILPPKSL-GIERIHFRK------------- 626 Query: 612 SESSLDEPYEKVKKRSSHSHSSSHKRFPSTGSCAEAGGGSNSLQNSPIRGLPHWNSQSSM 671 SS++E + V R S S+H T GG SM Sbjct: 627 --SSINEQF--VDTRQSREMLSTHSSPYKTLERRPQGG-------------------RSM 663 Query: 672 PSTPDLRVRSPHYVHSTRSVDISPTRLHSLALHFRHRSSSLESQGKLLGSENDTGSPDFY 731 P+TP V + + S S + H R RS SLESQ LL SE D+ P F Sbjct: 664 PTTP---------VLTRNAYSSSHLEPESSSQHCRQRSGSLESQSHLL-SEMDSDKPFFS 713 Query: 732 TPRTRSSNGSDPMDDCSSCTSHSSSEHYYPAQMNA-NYSTLAEDSPSKARQRQRQRQRAA 790 +++ S+ ++ +DD SS TS SS+E+Y + Y+T D+ ++ R+R +++ Sbjct: 714 LSKSQRSSSTEILDDGSSYTSQSSTEYYCVTPVTGPYYTTQTLDTRTRGRRRSKKQN--- 770 Query: 791 GALGSASSGSMPNLAARGGAGGAGGAGGGVYLHSQSQPSSQYRIKEYPLYIEGGATPVVV 850 + +++SGSMPNLA + GVY SQ PSS Y I Y Y E Sbjct: 771 --VSTSNSGSMPNLAQK------DSLRNGVYSKSQEPPSSSYYIAGYTPYAECDFYYSGG 822 Query: 851 RSLESDQEGHYSVKAQFKTSNSYTAGGLFKESWRGGGGDEGDTGRLTPSRSQILRTP--S 908 E+D EG YSV +++S Y G ++ E + R+ + LR P + Sbjct: 823 YVYENDTEGQYSVNPSYRSSAHY---GYERQRDYSRSFHEDEVDRVPHNPYATLRLPRKA 879 Query: 909 LGREGAHDKGAGRAAVSDELRQWYQRSTASHKEHSRLSHTSSTSSDSGSQYSTSSQSTFV 968 + K +A V++ LR WYQR AS ++ S +S SD GSQ V Sbjct: 880 AAKSEHITKNIHKALVAEHLRGWYQR--ASGQKDQGHSPQTSFDSDRGSQRCLGFAGLQV 937 Query: 969 AHSRVTRMPQMCKATSAALPQSQRSSTPSS-------EIGATPPSSPHH 1010 C +S A S SST +S IG + +P H Sbjct: 938 P----------CSPSSRASSYSSVSSTNASGNWRTQLTIGLSDYETPAH 976 >gi|217035131 hypothetical protein LOC55765 isoform 1 [Homo sapiens] Length = 663 Score = 225 bits (574), Expect = 1e-58 Identities = 147/332 (44%), Positives = 196/332 (59%), Gaps = 22/332 (6%) Query: 353 ANMGSKGKIISGSSGSLLSSGSQESDSSQSAKKDMLAALKSRQEALEETLRQRLEELKKL 412 + M SK ++ SG +L SG DS S K++ A+ +Q ALE L LEEL++L Sbjct: 84 STMESKDEVSDTDSGIILQSGP---DSPVSPMKELTHAVHKQQRALEARLEACLEELRRL 140 Query: 413 CLREAELTGKLPVEYPLDPGEEPPIVRRRIGTAFKLDEQKILPKGEEAELERLEREFAIQ 472 CLREAELTG LP EYPL PGE+ P VRRRIG A+KLD+ + E L LER+ A+Q Sbjct: 141 CLREAELTGTLPAEYPLKPGEKAPKVRRRIGAAYKLDDWAL---HREDPLSSLERQLALQ 197 Query: 473 SQITEAARRLASDPNVSKKLKKQRKTSYLNALKKLQEIENAINENRIKSGKKPTQRASLI 532 QITEAARRL + N+S++ ++QRK S L KKLQE++ + E R S +P A+L Sbjct: 198 LQITEAARRLCLEENLSRQARRQRKHSMLQEEKKLQELQRCLVERRRNS--EPPPAAALP 255 Query: 533 IDDGNIASEDSSLSDALVLEDEDSQVTSTISPLHSPHKGLPPRPPSHNRPPPPQSLEGLR 592 + AS+DSSLSD L+LE+E+SQV P P P PPS RP PPQ+LEGL+ Sbjct: 256 LGRELSASDDSSLSDGLLLEEEESQV-----PKPPPES---PAPPS--RPLPPQTLEGLQ 305 Query: 593 QMHYHRNDYDKSPIKPKMWSESSLDEPYEKVKKRSS-HSHSSSHKRFPSTGSCAEAGG-- 649 +++P++ W E+SLD PYEK +K S S SSS P G A + Sbjct: 306 PTGPEAGSPERAPVQNSPWKETSLDHPYEKPRKSSEPWSESSSPATTPQDGPSASSLWLL 365 Query: 650 GSNSLQNSPIRGLP-HWNSQSSMPSTPDLRVR 680 S PIRG+P W ++S P+TP+++ R Sbjct: 366 EPASYHVVPIRGVPGQWQGRTSAPATPEIQGR 397 Score = 45.4 bits (106), Expect = 3e-04 Identities = 24/50 (48%), Positives = 36/50 (72%), Gaps = 2/50 (4%) Query: 895 RLTPSRSQILRTPSLGREGAHDKGAGRAAVSDELRQWYQRS-TASHKEHS 943 RL PSRS+I+RTPSL ++ +G +AAVS+EL+ W++R+ S + HS Sbjct: 557 RLVPSRSRIVRTPSL-KDSPAGRGLSKAAVSEELKWWHERARLRSTRPHS 605 >gi|217035133 hypothetical protein LOC55765 isoform 2 [Homo sapiens] Length = 578 Score = 225 bits (573), Expect = 2e-58 Identities = 147/330 (44%), Positives = 195/330 (59%), Gaps = 22/330 (6%) Query: 355 MGSKGKIISGSSGSLLSSGSQESDSSQSAKKDMLAALKSRQEALEETLRQRLEELKKLCL 414 M SK ++ SG +L SG DS S K++ A+ +Q ALE L LEEL++LCL Sbjct: 1 MESKDEVSDTDSGIILQSGP---DSPVSPMKELTHAVHKQQRALEARLEACLEELRRLCL 57 Query: 415 REAELTGKLPVEYPLDPGEEPPIVRRRIGTAFKLDEQKILPKGEEAELERLEREFAIQSQ 474 REAELTG LP EYPL PGE+ P VRRRIG A+KLD+ + E L LER+ A+Q Q Sbjct: 58 REAELTGTLPAEYPLKPGEKAPKVRRRIGAAYKLDDWAL---HREDPLSSLERQLALQLQ 114 Query: 475 ITEAARRLASDPNVSKKLKKQRKTSYLNALKKLQEIENAINENRIKSGKKPTQRASLIID 534 ITEAARRL + N+S++ ++QRK S L KKLQE++ + E R S +P A+L + Sbjct: 115 ITEAARRLCLEENLSRQARRQRKHSMLQEEKKLQELQRCLVERRRNS--EPPPAAALPLG 172 Query: 535 DGNIASEDSSLSDALVLEDEDSQVTSTISPLHSPHKGLPPRPPSHNRPPPPQSLEGLRQM 594 AS+DSSLSD L+LE+E+SQV P P P PPS RP PPQ+LEGL+ Sbjct: 173 RELSASDDSSLSDGLLLEEEESQV-----PKPPPES---PAPPS--RPLPPQTLEGLQPT 222 Query: 595 HYHRNDYDKSPIKPKMWSESSLDEPYEKVKKRSS-HSHSSSHKRFPSTGSCAEAGG--GS 651 +++P++ W E+SLD PYEK +K S S SSS P G A + Sbjct: 223 GPEAGSPERAPVQNSPWKETSLDHPYEKPRKSSEPWSESSSPATTPQDGPSASSLWLLEP 282 Query: 652 NSLQNSPIRGLP-HWNSQSSMPSTPDLRVR 680 S PIRG+P W ++S P+TP+++ R Sbjct: 283 ASYHVVPIRGVPGQWQGRTSAPATPEIQGR 312 Score = 45.4 bits (106), Expect = 3e-04 Identities = 24/50 (48%), Positives = 36/50 (72%), Gaps = 2/50 (4%) Query: 895 RLTPSRSQILRTPSLGREGAHDKGAGRAAVSDELRQWYQRS-TASHKEHS 943 RL PSRS+I+RTPSL ++ +G +AAVS+EL+ W++R+ S + HS Sbjct: 472 RLVPSRSRIVRTPSL-KDSPAGRGLSKAAVSEELKWWHERARLRSTRPHS 520 >gi|4505257 moesin [Homo sapiens] Length = 577 Score = 152 bits (383), Expect = 2e-36 Identities = 124/473 (26%), Positives = 210/473 (44%), Gaps = 30/473 (6%) Query: 29 DRKLELLVQPKLLAKELLDLVASHFNLKEKEYFGIAFTDETGHLNWLQLDRRVLEHDFPK 88 D +LE +QP K+L D V L+E +FG+ + D G WL+L+++V D K Sbjct: 13 DAELEFAIQPNTTGKQLFDQVVKTIGLREVWFFGLQYQDTKGFSTWLKLNKKVTAQDVRK 72 Query: 89 KSGPVVLYFCVRFYIESISY-LKDNATIELFFLNAKSCIYKELIDVDSEVVFELASYILQ 147 +S P++ F +FY E +S L + T LFFL K I + I E LASY +Q Sbjct: 73 ES-PLLFKFRAKFYPEDVSEELIQDITQRLFFLQVKEGILNDDIYCPPETAVLLASYAVQ 131 Query: 148 EAKGDFSSNEVVRSDLKKLPALPTQALKEHP-SLAYCEDRVIEHYKKLNGQTRGQAIVNY 206 GDF+ L LP + L++H + E+R+ +++ G R A++ Y Sbjct: 132 SKYGDFNKEVHKSGYLAGDKLLPQRVLEQHKLNKDQWEERIQVWHEEHRGMLREDAVLEY 191 Query: 207 MSIVESLPTYGVHYYAVKDKQGIPWWLGLSYKGIFQYDYHDKVKPRKIFQWRQLENLYFR 266 + I + L YGV+Y+++K+K+G WLG+ G+ Y+ +D++ P+ F W ++ N+ F Sbjct: 192 LKIAQDLEMYGVNYFSIKNKKGSELWLGVDALGLNIYEQNDRLTPKIGFPWSEIRNISFN 251 Query: 267 EKKFSVEVHDPRRASVTRRTFGHSGIAVHTWYACPALI-KSIWAMAISQHQFYLDRKQSK 325 +KKF ++ D + +YA I K I A+ + H+ Y+ R+ K Sbjct: 252 DKKFVIKPIDKKAPD-------------FVFYAPRLRINKRILALCMGNHELYMRRR--K 296 Query: 326 SKIHAARSLSEIAIDLTETGTLKTSKLANMGSKGKIISGSSGSLLSSGSQESDSSQSAKK 385 + + A + ++ + L N K ++ + +E + K Sbjct: 297 PDTIEVQQMKAQAREEKHQKQMERAMLENEKKKREMAEKEKEKI----EREKEELMERLK 352 Query: 386 DMLAALKSRQEALEETLRQ--RLEELKKLCLREAELTGKLPVEYPLDPGEEPPIVRRRIG 443 + K Q+ LEE R+ LE+ +K EAE K E EE + Sbjct: 353 QIEEQTKKAQQELEEQTRRALELEQERKRAQSEAEKLAKERQE-----AEEAKEALLQAS 407 Query: 444 TAFKLDEQKILPKGEEAELERLEREFAIQSQITEAARRLASDPNVSKKLKKQR 496 K ++++ + E + E A Q + +EA V + L+K R Sbjct: 408 RDQKKTQEQLALEMAELTARISQLEMARQKKESEAVEWQQKAQMVQEDLEKTR 460 >gi|4506467 radixin [Homo sapiens] Length = 583 Score = 150 bits (380), Expect = 5e-36 Identities = 110/402 (27%), Positives = 187/402 (46%), Gaps = 39/402 (9%) Query: 29 DRKLELLVQPKLLAKELLDLVASHFNLKEKEYFGIAFTDETGHLNWLQLDRRVLEHDFPK 88 D +LE +QP K+L D V L+E +FG+ + D G+ WL+L+++V + D K Sbjct: 13 DAELEFAIQPNTTGKQLFDQVVKTVGLREVWFFGLQYVDSKGYSTWLKLNKKVTQQDV-K 71 Query: 89 KSGPVVLYFCVRFYIESISY-LKDNATIELFFLNAKSCIYKELIDVDSEVVFELASYILQ 147 K P+ F +F+ E +S L T LFFL K I + I E LASY +Q Sbjct: 72 KENPLQFKFRAKFFPEDVSEELIQEITQRLFFLQVKEAILNDEIYCPPETAVLLASYAVQ 131 Query: 148 EAKGDFSSNEVVRSDLKKLPALPTQALKEHP-SLAYCEDRVIEHYKKLNGQTRGQAIVNY 206 GD++ L LP + L++H + E+R+ +++ G R +++ Y Sbjct: 132 AKYGDYNKEIHKPGYLANDRLLPQRVLEQHKLTKEQWEERIQNWHEEHRGMLREDSMMEY 191 Query: 207 MSIVESLPTYGVHYYAVKDKQGIPWWLGLSYKGIFQYDYHDKVKPRKIFQWRQLENLYFR 266 + I + L YGV+Y+ +K+K+G WLG+ G+ Y++ DK+ P+ F W ++ N+ F Sbjct: 192 LKIAQDLEMYGVNYFEIKNKKGTELWLGVDALGLNIYEHDDKLTPKIGFPWSEIRNISFN 251 Query: 267 EKKFSVEVHDPRRASVTRRTFGHSGIAVHTWYACPALI-KSIWAMAISQHQFYLDRKQSK 325 +KKF ++ D + +YA I K I A+ + H+ Y+ R+ K Sbjct: 252 DKKFVIKPIDKKAPD-------------FVFYAPRLRINKRILALCMGNHELYMRRR--K 296 Query: 326 SKIHAARSLSEIAIDLTETGTLKTSKLANMGSKGKIISGSSGSLLSSGSQESDSSQSAKK 385 + + A + L+ ++L N K +I +E + + K+ Sbjct: 297 PDTIEVQQMKAQAREEKHQKQLERAQLENEKKKREI-----------AEKEKERIEREKE 345 Query: 386 DMLAALK-------SRQEALEETLRQRLE--ELKKLCLREAE 418 +++ LK Q+ LEE R+ LE + +K EAE Sbjct: 346 ELMERLKQIEEQTIKAQKELEEQTRKALELDQERKRAKEEAE 387 >gi|161702986 ezrin [Homo sapiens] Length = 586 Score = 144 bits (362), Expect = 6e-34 Identities = 117/484 (24%), Positives = 202/484 (41%), Gaps = 66/484 (13%) Query: 29 DRKLELLVQPKLLAKELLDLVASHFNLKEKEYFGIAFTDETGHLNWLQLDRRVLEHDFPK 88 D +LE +QP K+L D V L+E YFG+ + D G WL+LD++V + + Sbjct: 13 DAELEFAIQPNTTGKQLFDQVVKTIGLREVWYFGLHYVDNKGFPTWLKLDKKVSAQEV-R 71 Query: 89 KSGPVVLYFCVRFYIESISY-LKDNATIELFFLNAKSCIYKELIDVDSEVVFELASYILQ 147 K P+ F +FY E ++ L + T +LFFL K I + I E L SY +Q Sbjct: 72 KENPLQFKFRAKFYPEDVAEELIQDITQKLFFLQVKEGILSDEIYCPPETAVLLGSYAVQ 131 Query: 148 EAKGDFSSNEVVRSDLKKLPALPTQALKEHP-SLAYCEDRVIEHYKKLNGQTRGQAIVNY 206 GD++ L +P + + +H + EDR+ + + G + A++ Y Sbjct: 132 AKFGDYNKEVHKSGYLSSERLIPQRVMDQHKLTRDQWEDRIQVWHAEHRGMLKDNAMLEY 191 Query: 207 MSIVESLPTYGVHYYAVKDKQGIPWWLGLSYKGIFQYDYHDKVKPRKIFQWRQLENLYFR 266 + I + L YG++Y+ +K+K+G WLG+ G+ Y+ DK+ P+ F W ++ N+ F Sbjct: 192 LKIAQDLEMYGINYFEIKNKKGTDLWLGVDALGLNIYEKDDKLTPKIGFPWSEIRNISFN 251 Query: 267 EKKFSVEVHDPRRASVTRRTFGHSGIAVHTWYACPALI-KSIWAMAISQHQFYLDRKQSK 325 +KKF ++ D + +YA I K I + + H+ Y+ R++ Sbjct: 252 DKKFVIKPIDKKAPD-------------FVFYAPRLRINKRILQLCMGNHELYMRRRKP- 297 Query: 326 SKIHAARSLSEIAIDLTETGTLKTSKLANMGSKGKIISGSSGSLLSSGSQESDSSQSAKK 385 D E +K ++E + ++ Sbjct: 298 --------------DTIEVQQMKAQ-----------------------AREEKHQKQLER 320 Query: 386 DMLAALKSRQEALEETLRQRLEELKKLCLREAELTGKLPVEYPLDPGEEPPIVRRRIGTA 445 L K R+E +E Q + E ++L LR +Y + + +I A Sbjct: 321 QQLETEKKRRETVEREKEQMMREKEELMLRLQ--------DYEEKTKKAERELSEQIQRA 372 Query: 446 FKLDEQKILPKGEEAELERLEREFAIQSQITEAARRLASDPNVSKKLKKQRKTSYLNALK 505 +L+E++ K + E ERLE + + E R A D S++ Y + Sbjct: 373 LQLEEER---KRAQEEAERLEADRMAALRAKEELERQAVDQIKSQEQLAAELAEYTAKIA 429 Query: 506 KLQE 509 L+E Sbjct: 430 LLEE 433 >gi|21614499 ezrin [Homo sapiens] Length = 586 Score = 144 bits (362), Expect = 6e-34 Identities = 117/484 (24%), Positives = 202/484 (41%), Gaps = 66/484 (13%) Query: 29 DRKLELLVQPKLLAKELLDLVASHFNLKEKEYFGIAFTDETGHLNWLQLDRRVLEHDFPK 88 D +LE +QP K+L D V L+E YFG+ + D G WL+LD++V + + Sbjct: 13 DAELEFAIQPNTTGKQLFDQVVKTIGLREVWYFGLHYVDNKGFPTWLKLDKKVSAQEV-R 71 Query: 89 KSGPVVLYFCVRFYIESISY-LKDNATIELFFLNAKSCIYKELIDVDSEVVFELASYILQ 147 K P+ F +FY E ++ L + T +LFFL K I + I E L SY +Q Sbjct: 72 KENPLQFKFRAKFYPEDVAEELIQDITQKLFFLQVKEGILSDEIYCPPETAVLLGSYAVQ 131 Query: 148 EAKGDFSSNEVVRSDLKKLPALPTQALKEHP-SLAYCEDRVIEHYKKLNGQTRGQAIVNY 206 GD++ L +P + + +H + EDR+ + + G + A++ Y Sbjct: 132 AKFGDYNKEVHKSGYLSSERLIPQRVMDQHKLTRDQWEDRIQVWHAEHRGMLKDNAMLEY 191 Query: 207 MSIVESLPTYGVHYYAVKDKQGIPWWLGLSYKGIFQYDYHDKVKPRKIFQWRQLENLYFR 266 + I + L YG++Y+ +K+K+G WLG+ G+ Y+ DK+ P+ F W ++ N+ F Sbjct: 192 LKIAQDLEMYGINYFEIKNKKGTDLWLGVDALGLNIYEKDDKLTPKIGFPWSEIRNISFN 251 Query: 267 EKKFSVEVHDPRRASVTRRTFGHSGIAVHTWYACPALI-KSIWAMAISQHQFYLDRKQSK 325 +KKF ++ D + +YA I K I + + H+ Y+ R++ Sbjct: 252 DKKFVIKPIDKKAPD-------------FVFYAPRLRINKRILQLCMGNHELYMRRRKP- 297 Query: 326 SKIHAARSLSEIAIDLTETGTLKTSKLANMGSKGKIISGSSGSLLSSGSQESDSSQSAKK 385 D E +K ++E + ++ Sbjct: 298 --------------DTIEVQQMKAQ-----------------------AREEKHQKQLER 320 Query: 386 DMLAALKSRQEALEETLRQRLEELKKLCLREAELTGKLPVEYPLDPGEEPPIVRRRIGTA 445 L K R+E +E Q + E ++L LR +Y + + +I A Sbjct: 321 QQLETEKKRRETVEREKEQMMREKEELMLRLQ--------DYEEKTKKAERELSEQIQRA 372 Query: 446 FKLDEQKILPKGEEAELERLEREFAIQSQITEAARRLASDPNVSKKLKKQRKTSYLNALK 505 +L+E++ K + E ERLE + + E R A D S++ Y + Sbjct: 373 LQLEEER---KRAQEEAERLEADRMAALRAKEELERQAVDQIKSQEQLAAELAEYTAKIA 429 Query: 506 KLQE 509 L+E Sbjct: 430 LLEE 433 >gi|32967254 neurofibromin 2 isoform 2 [Homo sapiens] Length = 590 Score = 142 bits (357), Expect = 2e-33 Identities = 117/481 (24%), Positives = 218/481 (45%), Gaps = 35/481 (7%) Query: 29 DRKLELLVQPKLLAKELLDLVASHFNLKEKEYFGIAFTDETGHLNWLQLDRRVLEHDFPK 88 D ++E + K K+L DLV L+E +FG+ +T + + WL++D++VL+HD K Sbjct: 30 DAEMEFNCEMKWKGKDLFDLVCRTLGLRETWFFGLQYTIKDT-VAWLKMDKKVLDHDVSK 88 Query: 89 KSGPVVLYFCVRFYIESISY-LKDNATIELFFLNAKSCIYKELIDVDSEVVFELASYILQ 147 + PV +F +FY E+ L T LFFL K I E I E LASY +Q Sbjct: 89 EE-PVTFHFLAKFYPENAEEELVQEITQHLFFLQVKKQILDEKIYCPPEASVLLASYAVQ 147 Query: 148 EAKGDFSSNEVVRSDLKKLPALPTQALKEHPSLAYC-EDRVIEHYKKLNGQTRGQAIVNY 206 GD+ + R L + LP + + + E+R+ Y + G+ R +A + Y Sbjct: 148 AKYGDYDPSVHKRGFLAQEELLPKRVINLYQMTPEMWEERITAWYAEHRGRARDEAEMEY 207 Query: 207 MSIVESLPTYGVHYYAVKDKQGIPWWLGLSYKGIFQYDYHDKVKPRKIFQWRQLENLYFR 266 + I + L YGV+Y+A+++K+G LG+ G+ YD +++ P+ F W ++ N+ + Sbjct: 208 LKIAQDLEMYGVNYFAIRNKKGTELLLGVDALGLHIYDPENRLTPKISFPWNEIRNISYS 267 Query: 267 EKKFSVEVHDPRRASVTRRTFGHSGIAVHTWYACPALIKSIWAMAISQHQFYLDRKQSKS 326 +K+F+++ P + F S + V+ K I + I H ++ R+++ S Sbjct: 268 DKEFTIK---PLDKKIDVFKFNSSKLRVN---------KLILQLCIGNHDLFMRRRKADS 315 Query: 327 KIHAARSLSEIAIDLTETGTLKTSKLANMGSKGKIISGSSGSLLSSGSQESDSSQSAKKD 386 + ++ E K + + + ++ +E++ ++ + Sbjct: 316 -----LEVQQMKAQAREEKARKQMERQRLAREKQM------------REEAERTRDELER 358 Query: 387 MLAALKSRQEALEETLRQRLEELKKLCLREAELTGKLPVEYPLDPGEEPPIVRRRIGTAF 446 L +K E L R EE L +A++T + E ++R TA Sbjct: 359 RLLQMKEEATMANEAL-MRSEETADLLAEKAQITEEEAKLLAQKAAEAEQEMQRIKATAI 417 Query: 447 KLDEQKILPKGEEAELERLEREFAIQSQ-ITEAARRLASDPNVSKKLKKQRKTSYLNALK 505 + +E+K L + + E E L + A +S+ + A +L D +++ +++ K L Sbjct: 418 RTEEEKRLMEQKVLEAEVLALKMAEESERRAKEADQLKQDLQEAREAERRAKQKLLEIAT 477 Query: 506 K 506 K Sbjct: 478 K 478 >gi|32967266 neurofibromin 2 isoform 2 [Homo sapiens] Length = 590 Score = 142 bits (357), Expect = 2e-33 Identities = 117/481 (24%), Positives = 218/481 (45%), Gaps = 35/481 (7%) Query: 29 DRKLELLVQPKLLAKELLDLVASHFNLKEKEYFGIAFTDETGHLNWLQLDRRVLEHDFPK 88 D ++E + K K+L DLV L+E +FG+ +T + + WL++D++VL+HD K Sbjct: 30 DAEMEFNCEMKWKGKDLFDLVCRTLGLRETWFFGLQYTIKDT-VAWLKMDKKVLDHDVSK 88 Query: 89 KSGPVVLYFCVRFYIESISY-LKDNATIELFFLNAKSCIYKELIDVDSEVVFELASYILQ 147 + PV +F +FY E+ L T LFFL K I E I E LASY +Q Sbjct: 89 EE-PVTFHFLAKFYPENAEEELVQEITQHLFFLQVKKQILDEKIYCPPEASVLLASYAVQ 147 Query: 148 EAKGDFSSNEVVRSDLKKLPALPTQALKEHPSLAYC-EDRVIEHYKKLNGQTRGQAIVNY 206 GD+ + R L + LP + + + E+R+ Y + G+ R +A + Y Sbjct: 148 AKYGDYDPSVHKRGFLAQEELLPKRVINLYQMTPEMWEERITAWYAEHRGRARDEAEMEY 207 Query: 207 MSIVESLPTYGVHYYAVKDKQGIPWWLGLSYKGIFQYDYHDKVKPRKIFQWRQLENLYFR 266 + I + L YGV+Y+A+++K+G LG+ G+ YD +++ P+ F W ++ N+ + Sbjct: 208 LKIAQDLEMYGVNYFAIRNKKGTELLLGVDALGLHIYDPENRLTPKISFPWNEIRNISYS 267 Query: 267 EKKFSVEVHDPRRASVTRRTFGHSGIAVHTWYACPALIKSIWAMAISQHQFYLDRKQSKS 326 +K+F+++ P + F S + V+ K I + I H ++ R+++ S Sbjct: 268 DKEFTIK---PLDKKIDVFKFNSSKLRVN---------KLILQLCIGNHDLFMRRRKADS 315 Query: 327 KIHAARSLSEIAIDLTETGTLKTSKLANMGSKGKIISGSSGSLLSSGSQESDSSQSAKKD 386 + ++ E K + + + ++ +E++ ++ + Sbjct: 316 -----LEVQQMKAQAREEKARKQMERQRLAREKQM------------REEAERTRDELER 358 Query: 387 MLAALKSRQEALEETLRQRLEELKKLCLREAELTGKLPVEYPLDPGEEPPIVRRRIGTAF 446 L +K E L R EE L +A++T + E ++R TA Sbjct: 359 RLLQMKEEATMANEAL-MRSEETADLLAEKAQITEEEAKLLAQKAAEAEQEMQRIKATAI 417 Query: 447 KLDEQKILPKGEEAELERLEREFAIQSQ-ITEAARRLASDPNVSKKLKKQRKTSYLNALK 505 + +E+K L + + E E L + A +S+ + A +L D +++ +++ K L Sbjct: 418 RTEEEKRLMEQKVLEAEVLALKMAEESERRAKEADQLKQDLQEAREAERRAKQKLLEIAT 477 Query: 506 K 506 K Sbjct: 478 K 478 >gi|32451486 neurofibromin 2 isoform 2 [Homo sapiens] Length = 590 Score = 142 bits (357), Expect = 2e-33 Identities = 117/481 (24%), Positives = 218/481 (45%), Gaps = 35/481 (7%) Query: 29 DRKLELLVQPKLLAKELLDLVASHFNLKEKEYFGIAFTDETGHLNWLQLDRRVLEHDFPK 88 D ++E + K K+L DLV L+E +FG+ +T + + WL++D++VL+HD K Sbjct: 30 DAEMEFNCEMKWKGKDLFDLVCRTLGLRETWFFGLQYTIKDT-VAWLKMDKKVLDHDVSK 88 Query: 89 KSGPVVLYFCVRFYIESISY-LKDNATIELFFLNAKSCIYKELIDVDSEVVFELASYILQ 147 + PV +F +FY E+ L T LFFL K I E I E LASY +Q Sbjct: 89 EE-PVTFHFLAKFYPENAEEELVQEITQHLFFLQVKKQILDEKIYCPPEASVLLASYAVQ 147 Query: 148 EAKGDFSSNEVVRSDLKKLPALPTQALKEHPSLAYC-EDRVIEHYKKLNGQTRGQAIVNY 206 GD+ + R L + LP + + + E+R+ Y + G+ R +A + Y Sbjct: 148 AKYGDYDPSVHKRGFLAQEELLPKRVINLYQMTPEMWEERITAWYAEHRGRARDEAEMEY 207 Query: 207 MSIVESLPTYGVHYYAVKDKQGIPWWLGLSYKGIFQYDYHDKVKPRKIFQWRQLENLYFR 266 + I + L YGV+Y+A+++K+G LG+ G+ YD +++ P+ F W ++ N+ + Sbjct: 208 LKIAQDLEMYGVNYFAIRNKKGTELLLGVDALGLHIYDPENRLTPKISFPWNEIRNISYS 267 Query: 267 EKKFSVEVHDPRRASVTRRTFGHSGIAVHTWYACPALIKSIWAMAISQHQFYLDRKQSKS 326 +K+F+++ P + F S + V+ K I + I H ++ R+++ S Sbjct: 268 DKEFTIK---PLDKKIDVFKFNSSKLRVN---------KLILQLCIGNHDLFMRRRKADS 315 Query: 327 KIHAARSLSEIAIDLTETGTLKTSKLANMGSKGKIISGSSGSLLSSGSQESDSSQSAKKD 386 + ++ E K + + + ++ +E++ ++ + Sbjct: 316 -----LEVQQMKAQAREEKARKQMERQRLAREKQM------------REEAERTRDELER 358 Query: 387 MLAALKSRQEALEETLRQRLEELKKLCLREAELTGKLPVEYPLDPGEEPPIVRRRIGTAF 446 L +K E L R EE L +A++T + E ++R TA Sbjct: 359 RLLQMKEEATMANEAL-MRSEETADLLAEKAQITEEEAKLLAQKAAEAEQEMQRIKATAI 417 Query: 447 KLDEQKILPKGEEAELERLEREFAIQSQ-ITEAARRLASDPNVSKKLKKQRKTSYLNALK 505 + +E+K L + + E E L + A +S+ + A +L D +++ +++ K L Sbjct: 418 RTEEEKRLMEQKVLEAEVLALKMAEESERRAKEADQLKQDLQEAREAERRAKQKLLEIAT 477 Query: 506 K 506 K Sbjct: 478 K 478 >gi|4557795 neurofibromin 2 isoform 1 [Homo sapiens] Length = 595 Score = 142 bits (357), Expect = 2e-33 Identities = 117/481 (24%), Positives = 218/481 (45%), Gaps = 35/481 (7%) Query: 29 DRKLELLVQPKLLAKELLDLVASHFNLKEKEYFGIAFTDETGHLNWLQLDRRVLEHDFPK 88 D ++E + K K+L DLV L+E +FG+ +T + + WL++D++VL+HD K Sbjct: 30 DAEMEFNCEMKWKGKDLFDLVCRTLGLRETWFFGLQYTIKDT-VAWLKMDKKVLDHDVSK 88 Query: 89 KSGPVVLYFCVRFYIESISY-LKDNATIELFFLNAKSCIYKELIDVDSEVVFELASYILQ 147 + PV +F +FY E+ L T LFFL K I E I E LASY +Q Sbjct: 89 EE-PVTFHFLAKFYPENAEEELVQEITQHLFFLQVKKQILDEKIYCPPEASVLLASYAVQ 147 Query: 148 EAKGDFSSNEVVRSDLKKLPALPTQALKEHPSLAYC-EDRVIEHYKKLNGQTRGQAIVNY 206 GD+ + R L + LP + + + E+R+ Y + G+ R +A + Y Sbjct: 148 AKYGDYDPSVHKRGFLAQEELLPKRVINLYQMTPEMWEERITAWYAEHRGRARDEAEMEY 207 Query: 207 MSIVESLPTYGVHYYAVKDKQGIPWWLGLSYKGIFQYDYHDKVKPRKIFQWRQLENLYFR 266 + I + L YGV+Y+A+++K+G LG+ G+ YD +++ P+ F W ++ N+ + Sbjct: 208 LKIAQDLEMYGVNYFAIRNKKGTELLLGVDALGLHIYDPENRLTPKISFPWNEIRNISYS 267 Query: 267 EKKFSVEVHDPRRASVTRRTFGHSGIAVHTWYACPALIKSIWAMAISQHQFYLDRKQSKS 326 +K+F+++ P + F S + V+ K I + I H ++ R+++ S Sbjct: 268 DKEFTIK---PLDKKIDVFKFNSSKLRVN---------KLILQLCIGNHDLFMRRRKADS 315 Query: 327 KIHAARSLSEIAIDLTETGTLKTSKLANMGSKGKIISGSSGSLLSSGSQESDSSQSAKKD 386 + ++ E K + + + ++ +E++ ++ + Sbjct: 316 -----LEVQQMKAQAREEKARKQMERQRLAREKQM------------REEAERTRDELER 358 Query: 387 MLAALKSRQEALEETLRQRLEELKKLCLREAELTGKLPVEYPLDPGEEPPIVRRRIGTAF 446 L +K E L R EE L +A++T + E ++R TA Sbjct: 359 RLLQMKEEATMANEAL-MRSEETADLLAEKAQITEEEAKLLAQKAAEAEQEMQRIKATAI 417 Query: 447 KLDEQKILPKGEEAELERLEREFAIQSQ-ITEAARRLASDPNVSKKLKKQRKTSYLNALK 505 + +E+K L + + E E L + A +S+ + A +L D +++ +++ K L Sbjct: 418 RTEEEKRLMEQKVLEAEVLALKMAEESERRAKEADQLKQDLQEAREAERRAKQKLLEIAT 477 Query: 506 K 506 K Sbjct: 478 K 478 >gi|15826862 coiled-coil domain containing 120 isoform 3 [Homo sapiens] Length = 630 Score = 127 bits (319), Expect = 5e-29 Identities = 118/406 (29%), Positives = 178/406 (43%), Gaps = 58/406 (14%) Query: 355 MGSKGKIISGSSGSLLSSGSQESDSSQSAKKDMLAALKSRQEALEETLRQRLEELKKLCL 414 M KG++IS S + + + +++ K + L L RQ L+E L +L+EL+K+CL Sbjct: 1 MEVKGQLIS--SPTFNAPAALFGEAAPQVKSERLRGLLDRQRTLQEALSLKLQELRKVCL 58 Query: 415 REAELTGKLPVEYPLDPGEEPPIVRRRIGTA------FKLDEQKILPKGEEAELERLERE 468 +EAELTG+LP E PL+PGE P +VRRR TA L EE LE LERE Sbjct: 59 QEAELTGQLPPECPLEPGERPQLVRRRPPTARAYPPPHPNQAHHSLCPAEELALEALERE 118 Query: 469 FAIQSQITEAARRLASDPNVSKKLKKQRKTSYLNALKKLQEIENAINENRIKSGKKPTQR 528 ++Q QI AARRLA P++S + +++R+ +AL++L E+E + + R + G Sbjct: 119 VSVQQQIAAAARRLALAPDLSTEQRRRRRQVQADALRRLHELEEQLRDVRARLGLPVLPL 178 Query: 529 AS-LIIDDGNIASEDSSLSDALVLEDEDSQVTSTISPLHSPHKGLPPRPPSHNRPPPPQS 587 L + G++ + + + L +Q++ LHS L SH+ P Sbjct: 179 PQPLPLSTGSVIT-----TQGVCLGMRLAQLSQEDVVLHSESSSLSESGASHDNEEPHGC 233 Query: 588 LEGLRQMHYHRNDYDKSPIKPKMWSESSLDEPYEKVKKRSSHSHSSSHKRFPSTGSCAEA 647 + P PK W + + S S +R P ++ Sbjct: 234 F-----------SLAERPSPPKAWDQ------------LRAVSGGSPERRTPWKPPPSDL 270 Query: 648 GGGSNSLQN------SPIRGLPHWNSQ---SSMPSTPDLRVRSPHYVHSTRSVDISPTRL 698 G S +N SP R LP S S+P+TP L TR P Sbjct: 271 YGDLKSRRNSVASPTSPTRSLPRSASSFEGRSVPATPVL----------TRGA--GPQLC 318 Query: 699 HSLALHFRHRSSSLESQGKLLGSENDTGSPDFYTPRTRSSNGSDPM 744 LH R S S +SQ ++ + + RTR SN S+ + Sbjct: 319 KPEGLHSRQWSGSQDSQMGFPRADPASDRASLFVARTRRSNSSEAL 364 >gi|254039610 coiled-coil domain containing 120 isoform 1 [Homo sapiens] Length = 661 Score = 127 bits (319), Expect = 5e-29 Identities = 118/406 (29%), Positives = 178/406 (43%), Gaps = 58/406 (14%) Query: 355 MGSKGKIISGSSGSLLSSGSQESDSSQSAKKDMLAALKSRQEALEETLRQRLEELKKLCL 414 M KG++IS S + + + +++ K + L L RQ L+E L +L+EL+K+CL Sbjct: 1 MEVKGQLIS--SPTFNAPAALFGEAAPQVKSERLRGLLDRQRTLQEALSLKLQELRKVCL 58 Query: 415 REAELTGKLPVEYPLDPGEEPPIVRRRIGTA------FKLDEQKILPKGEEAELERLERE 468 +EAELTG+LP E PL+PGE P +VRRR TA L EE LE LERE Sbjct: 59 QEAELTGQLPPECPLEPGERPQLVRRRPPTARAYPPPHPNQAHHSLCPAEELALEALERE 118 Query: 469 FAIQSQITEAARRLASDPNVSKKLKKQRKTSYLNALKKLQEIENAINENRIKSGKKPTQR 528 ++Q QI AARRLA P++S + +++R+ +AL++L E+E + + R + G Sbjct: 119 VSVQQQIAAAARRLALAPDLSTEQRRRRRQVQADALRRLHELEEQLRDVRARLGLPVLPL 178 Query: 529 AS-LIIDDGNIASEDSSLSDALVLEDEDSQVTSTISPLHSPHKGLPPRPPSHNRPPPPQS 587 L + G++ + + + L +Q++ LHS L SH+ P Sbjct: 179 PQPLPLSTGSVIT-----TQGVCLGMRLAQLSQEDVVLHSESSSLSESGASHDNEEPHGC 233 Query: 588 LEGLRQMHYHRNDYDKSPIKPKMWSESSLDEPYEKVKKRSSHSHSSSHKRFPSTGSCAEA 647 + P PK W + + S S +R P ++ Sbjct: 234 F-----------SLAERPSPPKAWDQ------------LRAVSGGSPERRTPWKPPPSDL 270 Query: 648 GGGSNSLQN------SPIRGLPHWNSQ---SSMPSTPDLRVRSPHYVHSTRSVDISPTRL 698 G S +N SP R LP S S+P+TP L TR P Sbjct: 271 YGDLKSRRNSVASPTSPTRSLPRSASSFEGRSVPATPVL----------TRGA--GPQLC 318 Query: 699 HSLALHFRHRSSSLESQGKLLGSENDTGSPDFYTPRTRSSNGSDPM 744 LH R S S +SQ ++ + + RTR SN S+ + Sbjct: 319 KPEGLHSRQWSGSQDSQMGFPRADPASDRASLFVARTRRSNSSEAL 364 >gi|254039614 coiled-coil domain containing 120 isoform 4 [Homo sapiens] Length = 618 Score = 125 bits (313), Expect = 3e-28 Identities = 112/383 (29%), Positives = 167/383 (43%), Gaps = 56/383 (14%) Query: 378 DSSQSAKKDMLAALKSRQEALEETLRQRLEELKKLCLREAELTGKLPVEYPLDPGEEPPI 437 +++ K + L L RQ L+E L +L+EL+K+CL+EAELTG+LP E PL+PGE P + Sbjct: 10 EAAPQVKSERLRGLLDRQRTLQEALSLKLQELRKVCLQEAELTGQLPPECPLEPGERPQL 69 Query: 438 VRRRIGTA------FKLDEQKILPKGEEAELERLEREFAIQSQITEAARRLASDPNVSKK 491 VRRR TA L EE LE LERE ++Q QI AARRLA P++S + Sbjct: 70 VRRRPPTARAYPPPHPNQAHHSLCPAEELALEALEREVSVQQQIAAAARRLALAPDLSTE 129 Query: 492 LKKQRKTSYLNALKKLQEIENAINENRIKSGKKPTQRAS-LIIDDGNIASEDSSLSDALV 550 +++R+ +AL++L E+E + + R + G L + G++ + + + Sbjct: 130 QRRRRRQVQADALRRLHELEEQLRDVRARLGLPVLPLPQPLPLSTGSVIT-----TQGVC 184 Query: 551 LEDEDSQVTSTISPLHSPHKGLPPRPPSHNRPPPPQSLEGLRQMHYHRNDYDKSPIKPKM 610 L +Q++ LHS L SH+ P + P PK Sbjct: 185 LGMRLAQLSQEDVVLHSESSSLSESGASHDNEEPHGCF-----------SLAERPSPPKA 233 Query: 611 WSESSLDEPYEKVKKRSSHSHSSSHKRFPSTGSCAEAGGGSNSLQN------SPIRGLPH 664 W + + S S +R P ++ G S +N SP R LP Sbjct: 234 WDQ------------LRAVSGGSPERRTPWKPPPSDLYGDLKSRRNSVASPTSPTRSLPR 281 Query: 665 WNSQ---SSMPSTPDLRVRSPHYVHSTRSVDISPTRLHSLALHFRHRSSSLESQGKLLGS 721 S S+P+TP L TR P LH R S S +SQ + Sbjct: 282 SASSFEGRSVPATPVL----------TRGA--GPQLCKPEGLHSRQWSGSQDSQMGFPRA 329 Query: 722 ENDTGSPDFYTPRTRSSNGSDPM 744 + + + RTR SN S+ + Sbjct: 330 DPASDRASLFVARTRRSNSSEAL 352 >gi|254039612 coiled-coil domain containing 120 isoform 2 [Homo sapiens] Length = 649 Score = 125 bits (313), Expect = 3e-28 Identities = 112/383 (29%), Positives = 167/383 (43%), Gaps = 56/383 (14%) Query: 378 DSSQSAKKDMLAALKSRQEALEETLRQRLEELKKLCLREAELTGKLPVEYPLDPGEEPPI 437 +++ K + L L RQ L+E L +L+EL+K+CL+EAELTG+LP E PL+PGE P + Sbjct: 10 EAAPQVKSERLRGLLDRQRTLQEALSLKLQELRKVCLQEAELTGQLPPECPLEPGERPQL 69 Query: 438 VRRRIGTA------FKLDEQKILPKGEEAELERLEREFAIQSQITEAARRLASDPNVSKK 491 VRRR TA L EE LE LERE ++Q QI AARRLA P++S + Sbjct: 70 VRRRPPTARAYPPPHPNQAHHSLCPAEELALEALEREVSVQQQIAAAARRLALAPDLSTE 129 Query: 492 LKKQRKTSYLNALKKLQEIENAINENRIKSGKKPTQRAS-LIIDDGNIASEDSSLSDALV 550 +++R+ +AL++L E+E + + R + G L + G++ + + + Sbjct: 130 QRRRRRQVQADALRRLHELEEQLRDVRARLGLPVLPLPQPLPLSTGSVIT-----TQGVC 184 Query: 551 LEDEDSQVTSTISPLHSPHKGLPPRPPSHNRPPPPQSLEGLRQMHYHRNDYDKSPIKPKM 610 L +Q++ LHS L SH+ P + P PK Sbjct: 185 LGMRLAQLSQEDVVLHSESSSLSESGASHDNEEPHGCF-----------SLAERPSPPKA 233 Query: 611 WSESSLDEPYEKVKKRSSHSHSSSHKRFPSTGSCAEAGGGSNSLQN------SPIRGLPH 664 W + + S S +R P ++ G S +N SP R LP Sbjct: 234 WDQ------------LRAVSGGSPERRTPWKPPPSDLYGDLKSRRNSVASPTSPTRSLPR 281 Query: 665 WNSQ---SSMPSTPDLRVRSPHYVHSTRSVDISPTRLHSLALHFRHRSSSLESQGKLLGS 721 S S+P+TP L TR P LH R S S +SQ + Sbjct: 282 SASSFEGRSVPATPVL----------TRGA--GPQLCKPEGLHSRQWSGSQDSQMGFPRA 329 Query: 722 ENDTGSPDFYTPRTRSSNGSDPM 744 + + + RTR SN S+ + Sbjct: 330 DPASDRASLFVARTRRSNSSEAL 352 >gi|32967260 neurofibromin 2 isoform 5 [Homo sapiens] Length = 548 Score = 114 bits (286), Expect = 4e-25 Identities = 101/435 (23%), Positives = 191/435 (43%), Gaps = 34/435 (7%) Query: 75 LQLDRRVLEHDFPKKSGPVVLYFCVRFYIESISY-LKDNATIELFFLNAKSCIYKELIDV 133 ++ + VL+HD K+ PV +F +FY E+ L T LFFL K I E I Sbjct: 33 MEFNCEVLDHDVSKEE-PVTFHFLAKFYPENAEEELVQEITQHLFFLQVKKQILDEKIYC 91 Query: 134 DSEVVFELASYILQEAKGDFSSNEVVRSDLKKLPALPTQALKEHPSLAYC-EDRVIEHYK 192 E LASY +Q GD+ + R L + LP + + + E+R+ Y Sbjct: 92 PPEASVLLASYAVQAKYGDYDPSVHKRGFLAQEELLPKRVINLYQMTPEMWEERITAWYA 151 Query: 193 KLNGQTRGQAIVNYMSIVESLPTYGVHYYAVKDKQGIPWWLGLSYKGIFQYDYHDKVKPR 252 + G+ R +A + Y+ I + L YGV+Y+A+++K+G LG+ G+ YD +++ P+ Sbjct: 152 EHRGRARDEAEMEYLKIAQDLEMYGVNYFAIRNKKGTELLLGVDALGLHIYDPENRLTPK 211 Query: 253 KIFQWRQLENLYFREKKFSVEVHDPRRASVTRRTFGHSGIAVHTWYACPALIKSIWAMAI 312 F W ++ N+ + +K+F+++ P + F S + V+ K I + I Sbjct: 212 ISFPWNEIRNISYSDKEFTIK---PLDKKIDVFKFNSSKLRVN---------KLILQLCI 259 Query: 313 SQHQFYLDRKQSKSKIHAARSLSEIAIDLTETGTLKTSKLANMGSKGKIISGSSGSLLSS 372 H ++ R+++ S + ++ E K + + + ++ Sbjct: 260 GNHDLFMRRRKADS-----LEVQQMKAQAREEKARKQMERQRLAREKQM----------- 303 Query: 373 GSQESDSSQSAKKDMLAALKSRQEALEETLRQRLEELKKLCLREAELTGKLPVEYPLDPG 432 +E++ ++ + L +K E L R EE L +A++T + Sbjct: 304 -REEAERTRDELERRLLQMKEEATMANEAL-MRSEETADLLAEKAQITEEEAKLLAQKAA 361 Query: 433 EEPPIVRRRIGTAFKLDEQKILPKGEEAELERLEREFAIQSQ-ITEAARRLASDPNVSKK 491 E ++R TA + +E+K L + + E E L + A +S+ + A +L D +++ Sbjct: 362 EAEQEMQRIKATAIRTEEEKRLMEQKVLEAEVLALKMAEESERRAKEADQLKQDLQEARE 421 Query: 492 LKKQRKTSYLNALKK 506 +++ K L K Sbjct: 422 AERRAKQKLLEIATK 436 >gi|40254949 erythrocyte membrane protein band 4.1 like 5 [Homo sapiens] Length = 733 Score = 112 bits (279), Expect = 2e-24 Identities = 85/309 (27%), Positives = 136/309 (44%), Gaps = 20/309 (6%) Query: 22 CQVHLLDDRKLELLVQPKLLAKELLDLVASHFNLKEKEYFGIAFTDETGHLNWLQLDRRV 81 C+V LLD + + + K +EL D + H +L E +YFG+ F D +WL + + Sbjct: 45 CRVSLLDGTDVSVDLPKKAKGQELFDQIMYHLDLIESDYFGLRFMDSAQVAHWLDGTKSI 104 Query: 82 LEHDFPKKSGPVVLYFCVRFYIESISYLKDNATIELFFLNAKSCIYKELIDVDSEVVFEL 141 + K P L+ V+FY + L++ T LF L K I +D + +L Sbjct: 105 KKQ--VKIGSPYCLHLRVKFYSSEPNNLREELTRYLFVLQLKQDILSGKLDCPFDTAVQL 162 Query: 142 ASYILQEAKGDFSSNEVVRSDLKKLPALPTQALKEHPSLAYCEDRVIEHYKKLNGQTRGQ 201 A+Y LQ GD+ E + + +P Q E LA + E +K+ GQT Q Sbjct: 163 AAYNLQAELGDYDLAEHSPELVSEFRFVPIQT--EEMELA-----IFEKWKEYRGQTPAQ 215 Query: 202 AIVNYMSIVESLPTYGVHYYAVKDKQGIPWWLGLSYKGIFQYDYHDKVKPRKIFQWRQLE 261 A NY++ + L YGV + VK + G + LGL+ G+ ++ K+ +F W ++ Sbjct: 216 AETNYLNKAKWLEMYGVDMHVVKARDGNDYSLGLTPTGVLVFEGDTKI---GLFFWPKIT 272 Query: 262 NLYFREKKFS-VEVHDPRRASVTRRTFGHSGIAVHTWYACPALIKSIWAMAISQHQFYLD 320 L F++ K + V V D + TF P K +W A+ H F+ Sbjct: 273 RLDFKKNKLTLVVVEDDDQGKEQEHTFVFR-------LDHPKACKHLWKCAVEHHAFFRL 325 Query: 321 RKQSKSKIH 329 R + H Sbjct: 326 RGPVQKSSH 334 Score = 30.4 bits (67), Expect = 9.1 Identities = 47/211 (22%), Positives = 86/211 (40%), Gaps = 23/211 (10%) Query: 373 GSQESDSSQSAKKDMLAALK----SRQEALEETLRQRLEELKKLCLREAELTG-KLPVEY 427 G+ ++ + A D+ A + E ETL+ E+LK+L + + L + ++ Sbjct: 469 GASDTMETSQALNDVNVATRLPGLGEPEVEYETLKDTSEKLKQLEMENSPLLSPRSNIDV 528 Query: 428 PLDPGEEPPIVRRRIGTAFKLDEQKILPKGEEAELERLEREFAIQSQITEAARRLASDPN 487 ++ EE KL E+ + E L + +S I +A Sbjct: 529 NINSQEE----------VVKLTEKCLNNVIESPGLNVMRVPPDFKSNILKAQVEA----- 573 Query: 488 VSKKLKKQRKTSYLNALKKLQEIENAI-NENRIKSGKKPTQRASLII--DDGNIASEDSS 544 V K K+ S+ NA + +A+ NEN + K+ + LI D G++ E + Sbjct: 574 VHKVTKEDSLLSHKNANVQDAATNSAVLNENNVPLPKESLETLMLITPADSGSVLKEATD 633 Query: 545 LSDALVLEDEDSQVTSTISPLHSPHKGLPPR 575 DAL+ ++ + T++P S + PR Sbjct: 634 ELDALLASLTENLIDHTVAPQVSSTSMITPR 664 >gi|94721308 FERM domain containing 5 isoform 2 [Homo sapiens] Length = 570 Score = 109 bits (272), Expect = 2e-23 Identities = 84/314 (26%), Positives = 134/314 (42%), Gaps = 23/314 (7%) Query: 22 CQVHLLDDRKLELLVQPKLLAKELLDLVASHFNLKEKEYFGIAFTDETGHLNWLQLDRRV 81 C V LLDD + +Q + L DL+ H NL EK+YFGI F D +WL+ + V Sbjct: 19 CTVRLLDDSEYTCTIQRDAKGQYLFDLLCHHLNLLEKDYFGIRFVDPDKQRHWLEFTKSV 78 Query: 82 LEHDFPKKSGPVVLYFCVRFYIESISYLKDNATIELFFLNAKSCIYKELIDVDSEVVFEL 141 ++ + P + F V+FY + LK+ T L FL K +Y + + L Sbjct: 79 VKQ--LRSQPPFTMCFRVKFYPADPAALKEEITRYLVFLQIKRDLYHGRLLCKTSDAALL 136 Query: 142 ASYILQEAKGDFSSNEVVRSDLKKLPALPTQALKEHPSLAYCEDRVIEHYKKLNGQTRGQ 201 A+YILQ GD+ S + K P + K +A H +L+GQT Sbjct: 137 AAYILQAEIGDYDSGKHPEGYSSKFQFFPKHSEKLERKIAEI------HKTELSGQTPAT 190 Query: 202 AIVNYMSIVESLPTYGVHYYAVKDKQGIPWWLGLSYKGIFQYDYHDKVKPRKIFQWRQLE 261 + +N++ ++L TYGV + KD G +L + G + +V +W ++ Sbjct: 191 SELNFLRKAQTLETYGVDPHPCKDVSGNAAFLAFTPFGFVVLQGNKRV---HFIKWNEVT 247 Query: 262 NLYFREKKFSVEVHDPRRASVTRRTFGHSGIAVHTWYA-CPALIKSIWAMAISQHQFYLD 320 L F K F + V + + T++A P K +W I FY Sbjct: 248 KLKFEGKTFYLYVSQKEEKKI-----------ILTYFAPTPEACKHLWKCGIENQAFYKL 296 Query: 321 RKQSKSKIHAARSL 334 K S+ + ++ +L Sbjct: 297 EKSSQVRTVSSSNL 310 >gi|30061491 erythrocyte membrane protein band 4.1-like 1 isoform b [Homo sapiens] Length = 779 Score = 106 bits (264), Expect = 1e-22 Identities = 78/297 (26%), Positives = 132/297 (44%), Gaps = 21/297 (7%) Query: 22 CQVHLLDDRKLELLVQPKLLAKELLDLVASHFNLKEKEYFGIAFTDETGHLNWLQLDRRV 81 C+V LLD + E V+ + L DLV H NL EK+YFG+ F D NWL + + Sbjct: 37 CRVTLLDASEYECEVEKHGRGQVLFDLVCEHLNLLEKDYFGLTFCDADSQKNWLDPSKEI 96 Query: 82 LEHDFPKKSGPVVLYFCVRFYIESISYLKDNATIELFFLNAKSCIYKELIDVDSEVVFEL 141 + +S P F V+FY + L ++ T L ++ I + L Sbjct: 97 KKQ---IRSSPWNFAFTVKFYPPDPAQLTEDITRYYLCLQLRADIITGRLPCSFVTHALL 153 Query: 142 ASYILQEAKGDFSSNEVVRSDLKKLPALPTQALKEHPSLAYCEDRVIEHYKKLNGQTRGQ 201 SY +Q GD+ + E V + + +L P Q + E+R++E +K G T G+ Sbjct: 154 GSYAVQAELGDYDAEEHVGNYVSELRFAPNQTRE-------LEERIMELHKTYRGMTPGE 206 Query: 202 AIVNYMSIVESLPTYGVHYYAVKDKQGIPWWLGLSYKGIFQYDYHDKVKPRKIFQWRQLE 261 A ++++ + L YGV + KD +GI LG+ G+ Y D+++ + F W ++ Sbjct: 207 AEIHFLENAKKLSMYGVDLHHAKDSEGIDIMLGVCANGLL--IYRDRLRINR-FAWPKIL 263 Query: 262 NLYFREKKFSVEVHDPRRASVTRRTFGHSGIAVHTWYACPALIKSIWAMAISQHQFY 318 + ++ F +++ P T G + H K +W + I H F+ Sbjct: 264 KISYKRSNFYIKIR-PGEYEQFESTIGFK-LPNH------RSAKRLWKVCIEHHTFF 312 >gi|30061489 erythrocyte membrane protein band 4.1-like 1 isoform a [Homo sapiens] Length = 881 Score = 106 bits (264), Expect = 1e-22 Identities = 78/297 (26%), Positives = 132/297 (44%), Gaps = 21/297 (7%) Query: 22 CQVHLLDDRKLELLVQPKLLAKELLDLVASHFNLKEKEYFGIAFTDETGHLNWLQLDRRV 81 C+V LLD + E V+ + L DLV H NL EK+YFG+ F D NWL + + Sbjct: 99 CRVTLLDASEYECEVEKHGRGQVLFDLVCEHLNLLEKDYFGLTFCDADSQKNWLDPSKEI 158 Query: 82 LEHDFPKKSGPVVLYFCVRFYIESISYLKDNATIELFFLNAKSCIYKELIDVDSEVVFEL 141 + +S P F V+FY + L ++ T L ++ I + L Sbjct: 159 KKQ---IRSSPWNFAFTVKFYPPDPAQLTEDITRYYLCLQLRADIITGRLPCSFVTHALL 215 Query: 142 ASYILQEAKGDFSSNEVVRSDLKKLPALPTQALKEHPSLAYCEDRVIEHYKKLNGQTRGQ 201 SY +Q GD+ + E V + + +L P Q + E+R++E +K G T G+ Sbjct: 216 GSYAVQAELGDYDAEEHVGNYVSELRFAPNQTRE-------LEERIMELHKTYRGMTPGE 268 Query: 202 AIVNYMSIVESLPTYGVHYYAVKDKQGIPWWLGLSYKGIFQYDYHDKVKPRKIFQWRQLE 261 A ++++ + L YGV + KD +GI LG+ G+ Y D+++ + F W ++ Sbjct: 269 AEIHFLENAKKLSMYGVDLHHAKDSEGIDIMLGVCANGLL--IYRDRLRINR-FAWPKIL 325 Query: 262 NLYFREKKFSVEVHDPRRASVTRRTFGHSGIAVHTWYACPALIKSIWAMAISQHQFY 318 + ++ F +++ P T G + H K +W + I H F+ Sbjct: 326 KISYKRSNFYIKIR-PGEYEQFESTIGFK-LPNH------RSAKRLWKVCIEHHTFF 374 >gi|87042275 erythrocyte protein band 4.1-like 4 [Homo sapiens] Length = 686 Score = 106 bits (264), Expect = 1e-22 Identities = 89/319 (27%), Positives = 144/319 (45%), Gaps = 35/319 (10%) Query: 22 CQVHLLDDRKLELLVQPKLLAKE-----LLDLVASHFNLKEKEYFGIAFTDETGHLNWLQ 76 C+V LLD+ KL L Q + + K +LD V H NL E +YFG+ + D + WL Sbjct: 13 CEVLLLDESKLTLTTQQQGIKKSTKGSVVLDHVFHHVNLVEIDYFGLRYCDRSHQTYWLD 72 Query: 77 LDRRVLEHDFPKKSGP-VVLYFCVRFYIESISYLKDNATIELFFLNAKSCIYKELIDVDS 135 + + EH +GP LYF ++FY E LK+ T FFL K + + + Sbjct: 73 PAKTLAEHKELINTGPPYTLYFGIKFYAEDPCKLKEEITRYQFFLQVKQDVLQGRLPCPV 132 Query: 136 EVVFELASYILQEAKGDFSSNEVVRSDLKKLPALPTQALKEHPSLAYCEDRVIEHYKKLN 195 +L +Y +Q GD+ + + + +P Q KE E+ + +K L Sbjct: 133 NTAAQLGAYAIQSELGDYDPYKHTAGYVSEYRFVPDQ--KEE-----LEEAIERIHKTLM 185 Query: 196 GQTRGQAIVNYMSIVESLPTYGVHYYAVKDKQGIPWWLGLSYKGIFQYDYHDKVKPRKIF 255 GQ +A +NY+ +SL YGV + V + ++LGL+ G+ Y +K + K F Sbjct: 186 GQIPSEAELNYLRTAKSLEMYGVDLHPVYGENKSEYFLGLTPVGVVV--YKNKKQVGKYF 243 Query: 256 QWRQLENLYFREKKFSVEVHDPRRASVTRRTFGHSGIAVHTWYACPALIKSIWAMAISQH 315 W ++ ++F+E +F + V + + T F + AC K +W ++ H Sbjct: 244 -WPRITKVHFKETQFELRVLG-KDCNETSFFF-----EARSKTAC----KHLWKCSVEHH 292 Query: 316 QFY---------LDRKQSK 325 F+ L RK SK Sbjct: 293 TFFRMPENESNSLSRKLSK 311 >gi|117500790 FERM domain containing 3 [Homo sapiens] Length = 597 Score = 105 bits (262), Expect = 2e-22 Identities = 92/411 (22%), Positives = 175/411 (42%), Gaps = 43/411 (10%) Query: 16 MTEGRRCQVHLLDDRKLELLVQPKLLAKELLDLVASHFNLKEKEYFGIAFTDETGHLNWL 75 +++ RC + LLDD ++ +Q + + L+D + ++++L EK+YFGI + D +WL Sbjct: 28 LSQEMRCTIRLLDDSEISCHIQRETKGQFLIDHICNYYSLLEKDYFGIRYVDPEKQRHWL 87 Query: 76 QLDRRVLEHDFPKKSGPVVLYFCVRFYIESISYLKDNATIELFFLNAKSCIYKELIDVDS 135 + ++ + + K P + F V+FY +K+ T L +L K I+ + Sbjct: 88 EPNKSIFKQ--MKTHPPYTMCFRVKFYPHEPLKIKEELTRYLLYLQIKRDIFHGRLLCSF 145 Query: 136 EVVFELASYILQEAKGDFSSNEVVRSDLKKLPALPTQALKEHPSLAYCEDRVIE-HYKKL 194 L + I+Q GD+ +E + + + P Q+ K E +++E H +L Sbjct: 146 SDAAYLGACIVQAELGDYDPDEHPENYISEFEIFPKQSQK-------LERKIVEIHKNEL 198 Query: 195 NGQTRGQAIVNYMSIVESLPTYGVHYYAVKDKQGIPWWLGLSYKGIFQYDYHDKVKPRKI 254 GQ+ A N + +L TYGV + KD G +LG + G + + ++ + Sbjct: 199 RGQSPPVAEFNLLLKAHTLETYGVDPHPCKDSTGTTTFLGFTAAGFVVFQGNKRI---HL 255 Query: 255 FQWRQLENLYFREKKFSVEVHDPRRASVTRRTFGHSGIAVHTWYACPALIKSIWAMAISQ 314 +W + L F K F V + ++ +A HT + PA K +W + Sbjct: 256 IKWPDVCKLKFEGKTFYVIGTQKEKKAM---------LAFHT--STPAACKHLWKCGVEN 304 Query: 315 HQFYLDRKQSKSKIHAARSLSEIAIDLTETGTLKTSKLANMGSKGKIISGSSGSLLSSGS 374 FY K S+ K T+ +SK+ GS+ + + ++ + S Sbjct: 305 QAFYKYAKSSQIK------------------TVSSSKIFFKGSRFRYSGKVAKEVVEASS 346 Query: 375 QESDSSQSAKKDMLAALKSRQEALEETLRQRLEELKKLCLREAELTGKLPV 425 + + + +S +L + L +E L+ L +E +LP+ Sbjct: 347 KIQREPPEVHRANITQSRS-SHSLNKQLIINMEPLQPLLPSPSEQEEELPL 396 >gi|34916000 FERM domain containing 7 [Homo sapiens] Length = 714 Score = 102 bits (255), Expect = 1e-21 Identities = 77/305 (25%), Positives = 135/305 (44%), Gaps = 22/305 (7%) Query: 23 QVHLLDDRKLELLVQPKLLAKELLDLVASHFNLKEKEYFGIAFTDETGHLNWLQLDRRVL 82 +V LDD + +V K K L +L SH NL EKEYFG+ F +G+ WL+L + + Sbjct: 5 KVQFLDDSQKIFVVDQKSSGKALFNLSCSHLNLAEKEYFGLEFCSHSGNNVWLELLKPIT 64 Query: 83 EHDFPKKSGPVVLYFCVRFYIESISYLKDNATIELFFLNAKSCIYKELIDVDSEVVFELA 142 + K +V F V+F+ +L++ T LF L K + + + Sbjct: 65 KQ--VKNPKEIVFKFMVKFFPVDPGHLREELTRYLFTLQIKKDLALGRLPCSDNCTALMV 122 Query: 143 SYILQEAKGDFSSNEVVRSDLKKLPALPTQALKEHPSLAYCEDRVIEHYKKLNGQTRGQA 202 S+ILQ GDF E R L + LP Q E +++ ++K G++ ++ Sbjct: 123 SHILQSELGDF-HEETDRKHLAQTRYLPNQDC--------LEGKIMHFHQKHIGRSPAES 173 Query: 203 IVNYMSIVESLPTYGVHYYAVKDKQGIPWWLGLSYKGIFQYDYHDKVKPRKIFQWRQLEN 262 + + I L YG+ + D +G+ L +++ G+ + K+ F W ++ Sbjct: 174 DILLLDIARKLDMYGIRPHPASDGEGMQIHLAVAHMGVLVLRGNTKI---NTFNWAKIRK 230 Query: 263 LYFREKKFSVEVHDPRRASVTRRTFGHSGIAVHTWYACPALIKSIWAMAISQHQFYLDRK 322 L F+ K F +++H A++ + + AC K+ W + H F+ + Sbjct: 231 LSFKRKHFLIKLH----ANILVLCKDTLEFTMASRDAC----KAFWKTCVEYHAFFRLSE 282 Query: 323 QSKSK 327 + KSK Sbjct: 283 EPKSK 287 >gi|5031633 FERM, RhoGEF, and pleckstrin domain protein 1 isoform 1 [Homo sapiens] Length = 1045 Score = 100 bits (249), Expect = 7e-21 Identities = 78/305 (25%), Positives = 135/305 (44%), Gaps = 22/305 (7%) Query: 23 QVHLLDDRKLELLVQPKLLAKELLDLVASHFNLKEKEYFGIAFTDETGHLNWLQLDRRVL 82 ++ +LDD + V + K LLD V +H NL E +YFG+ F D WL L + ++ Sbjct: 43 KIQMLDDTQEAFEVPQRAPGKVLLDAVCNHLNLVEGDYFGLEFPDHKKITVWLDLLKPIV 102 Query: 83 EHDFPKKSGPVVLYFCVRFYIESISYLKDNATIELFFLNAKSCIYKELIDVDSEVVFELA 142 + ++ VV+ F V+F+ + L++ T LF L K + + + + L Sbjct: 103 KQ--IRRPKHVVVKFVVKFFPPDHTQLQEELTRYLFALQVKQDLAQGRLTCNDTSAALLI 160 Query: 143 SYILQEAKGDFSSNEVVRSDLKKLPALPTQALKEHPSLAYCEDRVIEHYKKLNGQTRGQA 202 S+I+Q GDF + R L K +P Q ED+++E + GQT ++ Sbjct: 161 SHIVQSEIGDF-DEALDREHLAKNKYIPQQDA--------LEDKIVEFHHNHIGQTPAES 211 Query: 203 IVNYMSIVESLPTYGVHYYAVKDKQGIPWWLGLSYKGIFQYDYHDKVKPRKIFQWRQLEN 262 + I L YG+ + KD++G L ++ GI + K+ F W ++ Sbjct: 212 DFQLLEIARRLEMYGIRLHPAKDREGTKINLAVANTGILVFQGFTKI---NAFNWAKVRK 268 Query: 263 LYFREKKFSVEVHDPRRASVTRRTFGHSGIAVHTWYACPALIKSIWAMAISQHQFYLDRK 322 L F+ K+F +++ P S + T + A KS W + + H F+ + Sbjct: 269 LSFKRKRFLIKLR-PDANSAYQDT-------LEFLMASRDFCKSFWKICVEHHAFFRLFE 320 Query: 323 QSKSK 327 + K K Sbjct: 321 EPKPK 325 >gi|32967262 neurofibromin 2 isoform 6 [Homo sapiens] Length = 549 Score = 100 bits (249), Expect = 7e-21 Identities = 101/480 (21%), Positives = 197/480 (41%), Gaps = 74/480 (15%) Query: 29 DRKLELLVQPKLLAKELLDLVASHFNLKEKEYFGIAFTDETGHLNWLQLDRRVLEHDFPK 88 D ++E + K K+L DLV L+E +FG+ +T + + WL++D++V Sbjct: 30 DAEMEFNCEMKWKGKDLFDLVCRTLGLRETWFFGLQYTIKDT-VAWLKMDKKV------- 81 Query: 89 KSGPVVLYFCVRFYIESISYLKDNATIELFFLNAKSCIYKELIDVDSEVVFELASYILQE 148 K I E I E LASY +Q Sbjct: 82 ----------------------------------KKQILDEKIYCPPEASVLLASYAVQA 107 Query: 149 AKGDFSSNEVVRSDLKKLPALPTQALKEHPSLAYC-EDRVIEHYKKLNGQTRGQAIVNYM 207 GD+ + R L + LP + + + E+R+ Y + G+ R +A + Y+ Sbjct: 108 KYGDYDPSVHKRGFLAQEELLPKRVINLYQMTPEMWEERITAWYAEHRGRARDEAEMEYL 167 Query: 208 SIVESLPTYGVHYYAVKDKQGIPWWLGLSYKGIFQYDYHDKVKPRKIFQWRQLENLYFRE 267 I + L YGV+Y+A+++K+G LG+ G+ YD +++ P+ F W ++ N+ + + Sbjct: 168 KIAQDLEMYGVNYFAIRNKKGTELLLGVDALGLHIYDPENRLTPKISFPWNEIRNISYSD 227 Query: 268 KKFSVEVHDPRRASVTRRTFGHSGIAVHTWYACPALIKSIWAMAISQHQFYLDRKQSKSK 327 K+F+++ P + F S + V+ K I + I H ++ R+++ S Sbjct: 228 KEFTIK---PLDKKIDVFKFNSSKLRVN---------KLILQLCIGNHDLFMRRRKADS- 274 Query: 328 IHAARSLSEIAIDLTETGTLKTSKLANMGSKGKIISGSSGSLLSSGSQESDSSQSAKKDM 387 + ++ E K + + + ++ +E++ ++ + Sbjct: 275 ----LEVQQMKAQAREEKARKQMERQRLAREKQM------------REEAERTRDELERR 318 Query: 388 LAALKSRQEALEETLRQRLEELKKLCLREAELTGKLPVEYPLDPGEEPPIVRRRIGTAFK 447 L +K E L R EE L +A++T + E ++R TA + Sbjct: 319 LLQMKEEATMANEAL-MRSEETADLLAEKAQITEEEAKLLAQKAAEAEQEMQRIKATAIR 377 Query: 448 LDEQKILPKGEEAELERLEREFAIQSQ-ITEAARRLASDPNVSKKLKKQRKTSYLNALKK 506 +E+K L + + E E L + A +S+ + A +L D +++ +++ K L K Sbjct: 378 TEEEKRLMEQKVLEAEVLALKMAEESERRAKEADQLKQDLQEAREAERRAKQKLLEIATK 437 >gi|7662310 FERM, RhoGEF and pleckstrin domain protein 2 [Homo sapiens] Length = 1054 Score = 98.6 bits (244), Expect = 3e-20 Identities = 79/325 (24%), Positives = 140/325 (43%), Gaps = 24/325 (7%) Query: 5 LVPDSALGLLMMTEGRRCQVHLLDDRKLELLVQPKLLAKELLDLVASHFNLKEKEYFGIA 64 L P L M + +V LLD+ ++PK + LL V NL E +YFG+ Sbjct: 29 LEPGQTLLPRMQEKHLHLRVKLLDNTMEIFDIEPKCDGQVLLTQVWKRLNLVECDYFGME 88 Query: 65 FTDETGHLNWLQLDRRVLEHDFPKKSGPVVLYFCVRFYIESISYLKDNATIELFFLNAKS 124 F + + WL+ + ++ K+ VVL V+F+ L++ T LF L K Sbjct: 89 FQNTQSYWIWLEPMKPIIRQIRRPKN--VVLRLAVKFFPPDPGQLQEEYTRYLFALQLKR 146 Query: 125 CIYKELIDVDSEVVFELASYILQEAKGDFSSNEVVRSDLKKLPALPTQALKEHPSLAYCE 184 + +E + L S++LQ GD+ + R LK LP Q +C Sbjct: 147 DLLEERLTCADTTAALLTSHLLQSEIGDYDET-LDREHLKVNEYLPGQQ--------HCL 197 Query: 185 DRVIEHYKKLNGQTRGQAIVNYMSIVESLPTYGVHYYAVKDKQGIPWWLGLSYKGIFQYD 244 ++++E ++K GQT ++ + I L YG+ ++ D++G L +S+ G+ + Sbjct: 198 EKILEFHQKHVGQTPAESDFQVLEIARKLEMYGIRFHMASDREGTKIQLAVSHMGVLVFQ 257 Query: 245 YHDKVKPRKIFQWRQLENLYFREKKFSVEVHDPRRASVTRRTFGHSGIAVHTWYACPALI 304 K+ F W ++ L F+ K+F +++H G + Sbjct: 258 GTTKI---NTFNWSKVRKLSFKRKRFLIKLHP--------EVHGPYQDTLEFLLGSRDEC 306 Query: 305 KSIWAMAISQHQFY--LDRKQSKSK 327 K+ W + + H F+ LD+ + K+K Sbjct: 307 KNFWKICVEYHTFFRLLDQPKPKAK 331 >gi|150418005 protein tyrosine phosphatase, non-receptor type 21 [Homo sapiens] Length = 1174 Score = 98.2 bits (243), Expect = 4e-20 Identities = 74/296 (25%), Positives = 132/296 (44%), Gaps = 17/296 (5%) Query: 23 QVHLLDDRKLELLVQPKLLAKELLDLVASHFNLKEKEYFGIAFTDETGHLNWLQLDRRVL 82 ++ LL++ +E + + +E L+ VA L+E YF + + ++ W+ L++ L Sbjct: 26 RIQLLNNEFVEFTLSVESTGQESLEAVAQRLELREVTYFSLWYYNKQNQRRWVDLEKP-L 84 Query: 83 EHDFPKKSGPVVLYFCVRFYIESISYLKDNATIELFFLNAKSCIYKELIDVDSEVVFELA 142 + K + +YF V FY+ S+S L+ T ++L K I + I E +LA Sbjct: 85 KKQLDKYALEPTVYFGVVFYVPSVSQLQQEITRYQYYLQLKKDILEGSIPCTLEQAIQLA 144 Query: 143 SYILQEAKGDFSSNEVVRSDLKKLPALPTQALKEHPSLAYCEDRVIEHYKKLNGQTRGQA 202 +Q GDF E + L+K P L++ L +V ++K G T A Sbjct: 145 GLAVQADFGDFDQYES-QDFLQKFALFPVGWLQDEKVLEEATQKVALLHQKYRGLTAPDA 203 Query: 203 IVNYMSIVESLPTYGVHYYAVKDKQGIPWWLGLSYKGIFQYDYHDKVKPRKIFQWRQLEN 262 + YM VE + YG Y KD QG +G +GIF H + +F+W + N Sbjct: 204 EMLYMQEVERMDGYGEESYPAKDSQGSDISIGACLEGIFV--KHKNGRHPVVFRWHDIAN 261 Query: 263 LYFREKKFSVEVHDPRRASVTRRTFGHSGIAVHTWYACPALIKSIWAMAISQHQFY 318 + + F++E+ + + ++ +T K IW + +++H+FY Sbjct: 262 MSHNKSFFALELAN-KEETIQFQTEDME------------TAKYIWRLCVARHKFY 304 >gi|32490572 erythrocyte membrane protein band 4.1-like 3 [Homo sapiens] Length = 1087 Score = 97.1 bits (240), Expect = 8e-20 Identities = 73/310 (23%), Positives = 132/310 (42%), Gaps = 21/310 (6%) Query: 9 SALGLLMMTEGRRCQVHLLDDRKLELLVQPKLLAKELLDLVASHFNLKEKEYFGIAFTDE 68 S L ++ + +C+V LLD + V+ + + L D V H NL EK+YFG+ + D Sbjct: 99 SPLKIVKKPKSMQCKVILLDGSEYTCDVEKRSRGQVLFDKVCEHLNLLEKDYFGLTYRDA 158 Query: 69 TGHLNWLQLDRRVLEHDFPKKSGPVVLYFCVRFYIESISYLKDNATIELFFLNAKSCIYK 128 NWL + + + +SG F V+FY + L ++ T L + I Sbjct: 159 ENQKNWLDPAKEIKKQ---VRSGAWHFSFNVKFYPPDPAQLSEDITRYYLCLQLRDDIVS 215 Query: 129 ELIDVDSEVVFELASYILQEAKGDFSSNEVVRSDLKKLPALPTQALKEHPSLAYCEDRVI 188 + + L SY +Q GD+ +E + + P + ED+VI Sbjct: 216 GRLPCSFVTLALLGSYTVQSELGDYDPDECGSDYISEFRFAPNHTKE-------LEDKVI 268 Query: 189 EHYKKLNGQTRGQAIVNYMSIVESLPTYGVHYYAVKDKQGIPWWLGLSYKGIFQYDYHDK 248 E +K G T +A ++++ + L YGV + KD +G+ LG+ G+ Y D+ Sbjct: 269 ELHKSHRGMTPAEAEMHFLENAKKLSMYGVDLHHAKDSEGVEIMLGVCASGLL--IYRDR 326 Query: 249 VKPRKIFQWRQLENLYFREKKFSVEVHDPRRASVTRRTFGHSGIAVHTWYACPALIKSIW 308 ++ + F W ++ + ++ F +++ P T G + H K +W Sbjct: 327 LRINR-FAWPKVLKISYKRNNFYIKIR-PGEFEQFESTIGFK-LPNH------RAAKRLW 377 Query: 309 AMAISQHQFY 318 + + H F+ Sbjct: 378 KVCVEHHTFF 387 >gi|110624794 erythrocyte membrane protein band 4.1 like 4B isoform 1 [Homo sapiens] Length = 518 Score = 97.1 bits (240), Expect = 8e-20 Identities = 76/308 (24%), Positives = 136/308 (44%), Gaps = 22/308 (7%) Query: 22 CQVHLLDDRKLELLVQPKLLAKELLDLVASHFNLKEKEYFGIAFTDETGHLNWLQLDRRV 81 C+V LLD ++ + + ++L D + H +L E +YFG+ F D +WL + + Sbjct: 87 CRVFLLDGTEVSVDLPKHAKGQDLFDQIVYHLDLVETDYFGLQFLDSAQVAHWLDHAKPI 146 Query: 82 LEHDFPKKSGPV-VLYFCVRFYIESISYLKDNATIELFFLNAKSCIYKELIDVDSEVVFE 140 + K GP L+F V++Y + L++ T LF L + I + E E Sbjct: 147 KKQ---MKIGPAYALHFRVKYYSSEPNNLREEFTRYLFVLQLRHDILSGKLKCPYETAVE 203 Query: 141 LASYILQEAKGDFSSNEVVRSDLKKLPALPTQALKEHPSLAYCEDRVIEHYKKLNGQTRG 200 LA+ LQ G+ E + + +P Q E + + +K+ G++ Sbjct: 204 LAALCLQAELGECELPEHTPELVSEFRFIPNQT-------EAMEFDIFQRWKECRGKSPA 256 Query: 201 QAIVNYMSIVESLPTYGVHYYAVKDKQGIPWWLGLSYKGIFQYDYHDKVKPRKIFQWRQL 260 QA ++Y++ + L YGV + V+ + G + LGL+ GI ++ +K+ +F W ++ Sbjct: 257 QAELSYLNKAKWLEMYGVDMHVVRGRDGCEYSLGLTPTGILIFEGANKI---GLFFWPKI 313 Query: 261 ENLYFREKKFS-VEVHDPRRASVTRRTFGHSGIAVHTWYACPALIKSIWAMAISQHQFYL 319 + F++ K + V V D + TF + T K +W A+ H F+ Sbjct: 314 TKMDFKKSKLTLVVVEDDDQGREQEHTFVFRLDSART-------CKHLWKCAVEHHAFFR 366 Query: 320 DRKQSKSK 327 R SK Sbjct: 367 LRTPGNSK 374 Database: hs.faa Posted date: Aug 4, 2009 4:42 PM Number of letters in database: 18,247,518 Number of sequences in database: 37,866 Lambda K H 0.312 0.128 0.369 Gapped Lambda K H 0.267 0.0410 0.140 Matrix: BLOSUM62 Gap Penalties: Existence: 11, Extension: 1 Number of Hits to DB: 42,100,671 Number of Sequences: 37866 Number of extensions: 2092867 Number of successful extensions: 15058 Number of sequences better than 10.0: 30 Number of HSP's better than 10.0 without gapping: 143 Number of HSP's successfully gapped in prelim test: 366 Number of HSP's that attempted gapping in prelim test: 13008 Number of HSP's gapped (non-prelim): 1976 length of query: 1039 length of database: 18,247,518 effective HSP length: 112 effective length of query: 927 effective length of database: 14,006,526 effective search space: 12984049602 effective search space used: 12984049602 T: 11 A: 40 X1: 16 ( 7.2 bits) X2: 38 (14.6 bits) X3: 64 (24.7 bits) S1: 42 (21.9 bits) S2: 67 (30.4 bits)
Search results were obtained with NCBI BLAST and RefSeq entries.
Guide to the Human Genome
Copyright © 2010 by Stewart Scherer. All rights reserved.