Search of human proteins with 23503317

BLASTP 2.2.11 [Jun-05-2005]


Reference: Altschul, Stephen F., Thomas L. Madden, Alejandro A. Schaffer, 
Jinghui Zhang, Zheng Zhang, Webb Miller, and David J. Lipman (1997), 
"Gapped BLAST and PSI-BLAST: a new generation of protein database search
programs",  Nucleic Acids Res. 25:3389-3402.

Query= gi|23503317 coiled-coil domain containing 96 [Homo sapiens]
         (555 letters)

Database: hs.faa 
           37,866 sequences; 18,247,518 total letters

Searching..................................................done

                                                                 Score    E
Sequences producing significant alignments:                      (bits) Value

gi|23503317 coiled-coil domain containing 96 [Homo sapiens]          1087   0.0  
gi|115648142 centrosomal protein 164kDa [Homo sapiens]                 92   1e-18
gi|19923432 coiled-coil domain containing 113 isoform 1 [Homo sa...    79   1e-14
gi|148746195 trichohyalin [Homo sapiens]                               77   5e-14
gi|41322923 plectin 1 isoform 11 [Homo sapiens]                        75   2e-13
gi|41322914 plectin 1 isoform 10 [Homo sapiens]                        75   2e-13
gi|41322919 plectin 1 isoform 8 [Homo sapiens]                         75   2e-13
gi|41322910 plectin 1 isoform 7 [Homo sapiens]                         75   2e-13
gi|41322916 plectin 1 isoform 6 [Homo sapiens]                         75   2e-13
gi|41322908 plectin 1 isoform 3 [Homo sapiens]                         75   2e-13
gi|41322912 plectin 1 isoform 2 [Homo sapiens]                         75   2e-13
gi|47607492 plectin 1 isoform 1 [Homo sapiens]                         75   2e-13
gi|214830928 coiled-coil domain containing 113 isoform 2 [Homo s...    75   2e-13
gi|117414137 retinitis pigmentosa 1-like 1 [Homo sapiens]              74   3e-13
gi|78190492 retinitis pigmentosa GTPase regulator isoform C [Hom...    70   4e-12
gi|153791497 ciliary rootlet coiled-coil [Homo sapiens]                70   4e-12
gi|118601081 heterogeneous nuclear ribonucleoprotein U-like 2 [H...    69   9e-12
gi|88196790 coiled-coil domain containing 88 [Homo sapiens]            66   7e-11
gi|44680105 caldesmon 1 isoform 1 [Homo sapiens]                       65   1e-10
gi|116284396 myosin, heavy chain 14 isoform 1 [Homo sapiens]           64   3e-10
gi|116284394 myosin, heavy chain 14 isoform 2 [Homo sapiens]           64   3e-10
gi|224831241 myosin, heavy chain 14 isoform 3 [Homo sapiens]           64   3e-10
gi|115511012 coiled-coil domain containing 136 [Homo sapiens]          63   6e-10
gi|45439327 periplakin [Homo sapiens]                                  63   8e-10
gi|31982906 cingulin-like 1 [Homo sapiens]                             62   2e-09
gi|4758650 kinesin family member 5C [Homo sapiens]                     61   3e-09
gi|71361682 nuclear mitotic apparatus protein 1 [Homo sapiens]         60   7e-09
gi|21735548 centrosomal protein 2 [Homo sapiens]                       59   9e-09
gi|34878777 ring finger protein 20 [Homo sapiens]                      59   9e-09
gi|157738649 neurofilament, medium polypeptide 150kDa isoform 1 ...    59   1e-08

>gi|23503317 coiled-coil domain containing 96 [Homo sapiens]
          Length = 555

 Score = 1087 bits (2812), Expect = 0.0
 Identities = 555/555 (100%), Positives = 555/555 (100%)

Query: 1   MDVSSEHTKDPGGEGGDGESLAARPSKIKASSGPPTSPEPGELESEPEEEEEEQAASQGG 60
           MDVSSEHTKDPGGEGGDGESLAARPSKIKASSGPPTSPEPGELESEPEEEEEEQAASQGG
Sbjct: 1   MDVSSEHTKDPGGEGGDGESLAARPSKIKASSGPPTSPEPGELESEPEEEEEEQAASQGG 60

Query: 61  TAADEQAEAPKGLTAAEAAGEEGPGEPGRPAEPQPEPEEPAEVGAEEPAQPEPGAGPEEL 120
           TAADEQAEAPKGLTAAEAAGEEGPGEPGRPAEPQPEPEEPAEVGAEEPAQPEPGAGPEEL
Sbjct: 61  TAADEQAEAPKGLTAAEAAGEEGPGEPGRPAEPQPEPEEPAEVGAEEPAQPEPGAGPEEL 120

Query: 121 EAEAGAEELEQAAEGKEVRFQASLPLTRIDEEEAAAAPEAETERVEGEEEDKEETQRDGA 180
           EAEAGAEELEQAAEGKEVRFQASLPLTRIDEEEAAAAPEAETERVEGEEEDKEETQRDGA
Sbjct: 121 EAEAGAEELEQAAEGKEVRFQASLPLTRIDEEEAAAAPEAETERVEGEEEDKEETQRDGA 180

Query: 181 ESKERDGEGRPAKSQEEGKRLYGRDEFEDLEWSEEVQKLQEQQLRSDLLDQYRSLLVERN 240
           ESKERDGEGRPAKSQEEGKRLYGRDEFEDLEWSEEVQKLQEQQLRSDLLDQYRSLLVERN
Sbjct: 181 ESKERDGEGRPAKSQEEGKRLYGRDEFEDLEWSEEVQKLQEQQLRSDLLDQYRSLLVERN 240

Query: 241 RSQRYNLYLQHKIFEALRRKKGLEAAEVADRGAEAEAPEKEQAYLRHLGMLEELKKQQAD 300
           RSQRYNLYLQHKIFEALRRKKGLEAAEVADRGAEAEAPEKEQAYLRHLGMLEELKKQQAD
Sbjct: 241 RSQRYNLYLQHKIFEALRRKKGLEAAEVADRGAEAEAPEKEQAYLRHLGMLEELKKQQAD 300

Query: 301 DLQWYHQELGQLKRQCQEKLTRVEKEWRRFQALKKQVVMQAMGSCRMRGGRQAALREVEQ 360
           DLQWYHQELGQLKRQCQEKLTRVEKEWRRFQALKKQVVMQAMGSCRMRGGRQAALREVEQ
Sbjct: 301 DLQWYHQELGQLKRQCQEKLTRVEKEWRRFQALKKQVVMQAMGSCRMRGGRQAALREVEQ 360

Query: 361 IQALEDKKEKEMSAVRLENIQLKQSLVHFETRMRTQEDLTQGLLLIDFEQLKIENQTFNE 420
           IQALEDKKEKEMSAVRLENIQLKQSLVHFETRMRTQEDLTQGLLLIDFEQLKIENQTFNE
Sbjct: 361 IQALEDKKEKEMSAVRLENIQLKQSLVHFETRMRTQEDLTQGLLLIDFEQLKIENQTFNE 420

Query: 421 KIEERNEELLKLRSKVTNSVQVITHVKEKLHFMDMENACKKTQLAEIEAQAALGRDILTK 480
           KIEERNEELLKLRSKVTNSVQVITHVKEKLHFMDMENACKKTQLAEIEAQAALGRDILTK
Sbjct: 421 KIEERNEELLKLRSKVTNSVQVITHVKEKLHFMDMENACKKTQLAEIEAQAALGRDILTK 480

Query: 481 TKQAREGLRTDNIRLNQKCGLLGKDSLLRDLEEKVDKTELLHRRLESLKRHHASLTLSCR 540
           TKQAREGLRTDNIRLNQKCGLLGKDSLLRDLEEKVDKTELLHRRLESLKRHHASLTLSCR
Sbjct: 481 TKQAREGLRTDNIRLNQKCGLLGKDSLLRDLEEKVDKTELLHRRLESLKRHHASLTLSCR 540

Query: 541 GVRQKIREAKAFLPS 555
           GVRQKIREAKAFLPS
Sbjct: 541 GVRQKIREAKAFLPS 555


>gi|115648142 centrosomal protein 164kDa [Homo sapiens]
          Length = 1460

 Score = 92.0 bits (227), Expect = 1e-18
 Identities = 136/586 (23%), Positives = 257/586 (43%), Gaps = 75/586 (12%)

Query: 19   ESLAARPSKIKASSGPPTSPEPGELESEPEEEEEEQAASQGGTAADEQAEAPKGLTAAEA 78
            E   + P  +     PP  PE      E EE  E+ AAS     + ++ +AP    A E 
Sbjct: 479  ERAQSPPRSLATEEEPPQGPEGQPEWKEAEELGEDSAASLSLQLSLQREQAPSPPAACEK 538

Query: 79   AGEE-------GPGEPGRPAEPQPEPEEPAEVGAEEPAQPE-----PGAGPEELEAEAGA 126
              E+       GPG+     E   +PEE   V    P  PE     P A PE+L +EA  
Sbjct: 539  GKEQHSQAEELGPGQ-----EEAEDPEEKVAVSPTPPVSPEVRSTEPVAPPEQL-SEAAL 592

Query: 127  EELEQAAEGKEVRFQASLPLTRIDE-----EEAAAAPEAETERVEGEEEDKEETQRDGAE 181
            + +E+A      + Q  L  ++ ++     E+     E E  R+  ++E    + R+  +
Sbjct: 593  KAMEEAVAQVLEQDQRHLLESKQEKMQQLREKLCQEEEEEILRLHQQKEQSLSSLRERLQ 652

Query: 182  SKERDGEGRPAKSQEEGKRL-YGRDEFEDLEWSEEVQKLQEQQLRSDLLDQYRSLLVERN 240
                + E R    +EE +RL + R + +    ++E Q   EQ+     L + R  L  + 
Sbjct: 653  KAIEEEEAR--MREEESQRLSWLRAQVQSSTQADEDQIRAEQEAS---LQKLREELESQQ 707

Query: 241  RSQRYNLYLQHK-IFEALRRKKGLEAAEVADRGAEAEAPEKEQAYLRHLGMLEELKKQQA 299
            +++R +L  +++ + E L  K+ +EA+E +++ A   A EK    LR    LE  +K+  
Sbjct: 708  KAERASLEQKNRQMLEQL--KEEIEASEKSEQAALNAAKEKALQQLRE--QLEGERKEAV 763

Query: 300  DDLQWYHQELGQLKRQC-------QEKLTRVEKEWRRFQALKKQVVMQAMGSCRMR---- 348
              L+  H    +L+R C       +E ++ ++K+ +  Q  ++  + + +G    R    
Sbjct: 764  ATLEKEHS--AELERLCSSLEAKHREVVSSLQKKIQEAQQKEEAQLQKCLGQVEHRVHQK 821

Query: 349  ----GGRQAALREV--EQIQALEDKKEKEMSAVRLENIQ-LKQSLVHFETRMRTQEDLTQ 401
                 G +  L  +  E+ Q +E + E+ +  ++ E+ Q + ++   +E   R Q     
Sbjct: 822  SYHVAGYEHELSSLLREKRQEVEGEHERRLDKMKEEHQQVMAKAREQYEAEERKQRAELL 881

Query: 402  GLLLIDFEQL----KIENQTFNEKIEERNEELLKLRSKVTNSVQVI--------THVKEK 449
            G L  + E+L    + E +T  ++  +R E+L +   +    +Q +          VK +
Sbjct: 882  GHLTGELERLQRAHERELETVRQEQHKRLEDLRRRHREQERKLQDLELDLETRAKDVKAR 941

Query: 450  LHFMDMENAC---KKTQLAEIEAQAALGRDILTKTKQAREGLRTDNIRLNQKCGLLGKDS 506
            L  ++++      +K QL +++ Q AL  +  T T Q  E  + ++  L Q    L +  
Sbjct: 942  LALLEVQEETARREKQQLLDVQRQVALKSEEATATHQQLEEAQKEHTHLLQSNQQLRE-- 999

Query: 507  LLRDLEEKVDKTE----LLHRRLESLKRHHASLTLSCRGVRQKIRE 548
            +L +L+ +  K E    LL  + + L++H +SL    +  +  +RE
Sbjct: 1000 ILDELQARKLKLESQVDLLQAQSQQLQKHFSSLEAEAQKKQHLLRE 1045



 Score = 55.1 bits (131), Expect = 2e-07
 Identities = 124/590 (21%), Positives = 229/590 (38%), Gaps = 127/590 (21%)

Query: 6   EHTKDPGGEGGDGESLAARPSKIKASSGPPTSPEPGELESEPEEEEEEQAASQGGT---- 61
           E T D G EG   E  A  P K  ++    +S    ELE     +E + + S        
Sbjct: 349 EDTVDAGEEGSRREEAAKEPKKKASALEEGSSDASQELEISEHMKEPQLSDSIASDPKSF 408

Query: 62  --------------------------AADEQAEAPKGL---TAAEAAGEEGPGEPGRPAE 92
                                      A  QA+ P G+     ++++ +E   +  +  E
Sbjct: 409 HGLDFGFRSRISEHLLDVDVLSPVLGGACRQAQQPLGIEDKDDSQSSQDELQSKQSKGLE 468

Query: 93  PQPEPEEPAEVGAEEP-----AQPEPGAGPEELEAEAGAEELEQAAEGKEVRFQASLPLT 147
            +  P  P E  A+ P      + EP  GPE       AEEL + +        ASL L 
Sbjct: 469 ERLSPPLPHEERAQSPPRSLATEEEPPQGPEGQPEWKEAEELGEDS-------AASLSLQ 521

Query: 148 RIDEEEAAAAPEAETERVEGEEEDKEETQRDGAESKERDGEGRPAKSQEEGKRLYGRDEF 207
              + E A +P A  E+  G+E+  +  +    + +  D E + A S           E 
Sbjct: 522 LSLQREQAPSPPAACEK--GKEQHSQAEELGPGQEEAEDPEEKVAVSPTPPV----SPEV 575

Query: 208 EDLEWSEEVQKLQEQQLRSDLLDQYRSLLVERNRSQRYNLYLQHKIFEALRRKKGLEAAE 267
              E     ++L E  L++  +++  + ++E++  QR+ L  + +  + LR K       
Sbjct: 576 RSTEPVAPPEQLSEAALKA--MEEAVAQVLEQD--QRHLLESKQEKMQQLREKL------ 625

Query: 268 VADRGAEAEAPEKEQAYLRHLGMLEELKKQQADDLQWYHQELGQLKRQCQEKLTRV-EKE 326
                      E+E+  LR    L + K+Q    L+       +L++  +E+  R+ E+E
Sbjct: 626 ---------CQEEEEEILR----LHQQKEQSLSSLR------ERLQKAIEEEEARMREEE 666

Query: 327 WRRFQALKKQVVMQAMG-SCRMRGGRQAALREVEQIQALEDKKEKEMSAVRLENIQLKQS 385
            +R   L+ QV         ++R  ++A+L+++   + LE +++ E +++  +N Q+   
Sbjct: 667 SQRLSWLRAQVQSSTQADEDQIRAEQEASLQKLR--EELESQQKAERASLEQKNRQM--- 721

Query: 386 LVHFETRMRTQEDLTQGLLLIDFEQLKIENQTFNEKIEE------RNEELLKLRSKVTNS 439
                                  EQLK E +  +EK E+      + + L +LR ++   
Sbjct: 722 ----------------------LEQLKEEIEA-SEKSEQAALNAAKEKALQQLREQLEGE 758

Query: 440 VQVITHVKEKLHFMDMENACKKTQLAEIEAQAALGRDI----LTKTKQAREGLRTDNIRL 495
            +      EK H  ++E  C   +    E  ++L + I      +  Q ++ L     R+
Sbjct: 759 RKEAVATLEKEHSAELERLCSSLEAKHREVVSSLQKKIQEAQQKEEAQLQKCLGQVEHRV 818

Query: 496 NQKCGLLG-----KDSLLRDLEEKVDKTELLHRRLESLKRHHASLTLSCR 540
           +QK   +        SLLR+  ++V+      RRL+ +K  H  +    R
Sbjct: 819 HQKSYHVAGYEHELSSLLREKRQEVEGEH--ERRLDKMKEEHQQVMAKAR 866



 Score = 36.6 bits (83), Expect = 0.062
 Identities = 47/192 (24%), Positives = 76/192 (39%), Gaps = 23/192 (11%)

Query: 43  LESEPEEEEEEQAASQGGTAADEQAEAPKGLTAAEAAGEEGPGEPGRPAEPQ-------- 94
           L  E  EE+EE++ +Q   ++ E       L      G+    E  R ++P+        
Sbjct: 214 LGEETNEEDEEESDNQSVHSSSEPLRNLH-LDIGALGGDFEYEESLRTSQPEEKKDVSLD 272

Query: 95  ------PEPEEPAEVGAEEPAQPEPGAGPEELEAEAGAEELEQAAEGKEVRFQASLPLTR 148
                 P P +P+  GA+       G G +   A  G  E E+  E  E +   +L   +
Sbjct: 273 SDAAGPPTPCKPSSPGADSSLSSAVGKGRQGSGARPGLPEKEEN-EKSEPKICRNLVTPK 331

Query: 149 IDEEEAAAAPEAETERVEGEEEDKEETQRDGAESKERDGEGRPAKSQEEGKRLYGRDEFE 208
            D   +  A  +E E  E   +  EE  R    +KE     + A + EEG      D  +
Sbjct: 332 ADPTGSEPAKASEKEAPEDTVDAGEEGSRREEAAKEPK---KKASALEEGSS----DASQ 384

Query: 209 DLEWSEEVQKLQ 220
           +LE SE +++ Q
Sbjct: 385 ELEISEHMKEPQ 396


>gi|19923432 coiled-coil domain containing 113 isoform 1 [Homo
           sapiens]
          Length = 377

 Score = 78.6 bits (192), Expect = 1e-14
 Identities = 77/295 (26%), Positives = 140/295 (47%), Gaps = 33/295 (11%)

Query: 254 FEALRRKKGLEAAEVADRGAEAEAPEKEQAYLRHLG-MLEELKKQQAD---DLQWYHQEL 309
           F   RR K        DRG    A +K +   + +  M ++L+  +A+   DLQ  H E 
Sbjct: 77  FRGRRRSKSRTGM---DRGVGLTADQKLELVQKEVADMKDDLRHTRANAERDLQ--HHEA 131

Query: 310 GQLKRQCQEKLTRVEKEWRRFQALKKQVVMQAMGSCRMRGGRQAALREVEQIQALEDKKE 369
             +  + + + + V +E   F+    + +++A+   + +G   A  + ++ I+ +  +++
Sbjct: 132 --IIEEAEIRWSEVSREVHEFE----KDILKAIS--KKKGSILATQKVMKYIEDMNRRRD 183

Query: 370 KEMSAVRLENIQLKQSLVHFETRMRTQEDLTQGLLLIDFEQLKIENQTFNEKIEERNEEL 429
                +RL+N+ LK        ++R +E++++ L  +DF+QLKIEN  F E IE RN+EL
Sbjct: 184 NMKEKLRLKNVSLKVQRKKMLLQLRQKEEVSEALHDVDFQQLKIENAQFLETIEARNQEL 243

Query: 430 LKLRSKVTNSVQVITHVKEKLH-------FMDMENACKKTQLAEIEAQAALGRDILTKTK 482
            +L+    N++QV+   K KLH        +D E   +K  L +IE +     +   K +
Sbjct: 244 TQLKLSSGNTLQVLNAYKSKLHKAMEIYLNLDKEILLRKELLEKIEKETLQVEEDRAKAE 303

Query: 483 QAREGLRTD--NIRLNQKCGLLGKDSLLRDLEEKVDKTELLHRRLE----SLKRH 531
              + LR      R  Q    + +  L  DLE+ +    +  R++E    SLK H
Sbjct: 304 AVNKRLRKQLAEFRAPQVMTYVREKILNADLEKSI---RMWERKVEIAEMSLKGH 355


>gi|148746195 trichohyalin [Homo sapiens]
          Length = 1943

 Score = 76.6 bits (187), Expect = 5e-14
 Identities = 120/506 (23%), Positives = 208/506 (41%), Gaps = 52/506 (10%)

Query: 39  EPGELESEPEEEEEEQAASQGGTAADEQAEAPKGLTAAEAAGEEGPGEPGRPAEPQPEPE 98
           EPG+   +  +E+E + A       +EQ+E  + L   +                Q   E
Sbjct: 132 EPGQRRRQKRQEQERELAE-----GEEQSEKQERLEQRDR---------------QRRDE 171

Query: 99  EPAEVGAEEPAQPEPGAGPEELEAEAGAEELEQAAEGKEVRFQASLPLTRIDEEEAAAAP 158
           E      E   + E  A  E+L++  G  E E+  + +++R +  L L R   EE     
Sbjct: 172 ELWRQRQEWQEREERRAEEEQLQSCKG-HETEEFPDEEQLRRRELLELRRKGREEKQQQR 230

Query: 159 EAETERVEGEEEDKEETQRDGAESKERD-------GEGRPAKSQEEGKRLYGRDEFEDLE 211
               +RV  EEE+KE  +R+    KE +          R  + +EE  R   R E     
Sbjct: 231 RERQDRVFQEEEEKEWRKRETVLRKEEEKLQEEEPQRQRELQEEEEQLRKLERQELRRER 290

Query: 212 WSEEVQK---LQEQQLRSDLLDQYRSLLVERNRSQRYNLYLQHKIFEALRRKKGLEAAEV 268
             EE Q+    +EQQLR    ++ R    ER   Q      + +  + LRR++  E    
Sbjct: 291 QEEEQQQQRLRREQQLRRKQEEERREQQEERREQQERREQQEERREQQLRREQ--EERRE 348

Query: 269 ADRGAEAEAPEKEQAYLRHLGMLEELKKQQADDLQWYHQELGQLKRQCQEKLTRVEKEWR 328
                E E   +EQ   R     EE ++QQ    Q   +E  QL+R   E+  R E++ R
Sbjct: 349 QQLRREQEEERREQQLRRE--QEEERREQQLRREQQLRRE-QQLRR---EQQLRREQQLR 402

Query: 329 RFQALKKQVVMQAMGSCRMRGGRQAALREVEQIQALEDKKEKEMSAVRL--ENIQLKQSL 386
           R Q L+++  ++     R    R+  LR  ++ +  E K E+E    RL  E  + +  L
Sbjct: 403 REQQLRREQQLRREQQLR----REQQLRREQEEERHEQKHEQERREQRLKREQEERRDWL 458

Query: 387 VHFETRMRTQEDLTQGLLLIDFEQ------LKIENQTFNEKIEERNEELLKLRSKVTNSV 440
              E   R +++  +  L  D E+      LK+E +   E+ +ER E+ L+   +     
Sbjct: 459 KREEETERHEQERRKQQLKRDQEEERRERWLKLEEEERREQ-QERREQQLRREQEERREQ 517

Query: 441 QVITHVKEKLHFMDMENACKKTQLAEIEAQAALGRDILTKTKQAREGLRTDNIRLNQKCG 500
           ++    +E+     + +  +  +  E   +  L R+   + +Q R   R    +  ++  
Sbjct: 518 RLKRQEEEERLQQRLRSEQQLRREQEERREQLLKREEEKRLEQERREQRLKREQEERRDQ 577

Query: 501 LLGKDSLLRDLEEKVDKTELLHRRLE 526
           LL ++   R    K ++ E L +RL+
Sbjct: 578 LLKREEERRQQRLKREQEERLEQRLK 603



 Score = 75.5 bits (184), Expect = 1e-13
 Identities = 107/498 (21%), Positives = 219/498 (43%), Gaps = 44/498 (8%)

Query: 44   ESEPEEEEEEQAASQGGTAADEQAEAPKGLTAAEAAGEEGP-GEPGRPAEPQPEPEEPAE 102
            ESE + +EEE+A  Q      ++ E  +  T    A E+   G     A P    +   +
Sbjct: 743  ESELQWQEEERAHRQ-----QQEEEQRRDFTWQWQAEEKSERGRQRLSARPPLREQRERQ 797

Query: 103  VGAEEPAQPEPGAGPEELEAEAGAEELEQAAEGKEVRFQASLPLTRIDEEEAAAAPEAET 162
            + AEE  Q E    PEE E E      ++    KE++F        ++EEE     E   
Sbjct: 798  LRAEERQQREQRFLPEEEEKE--QRRRQRREREKELQF--------LEEEEQLQRRERAQ 847

Query: 163  ERVEGEEEDKEETQRDGAESKERDGEGRPAKSQEEGKR---LYGRDEFEDLEWSEEVQKL 219
            +  E E+  +E+ +R  ++ + RD + R    +E  +R   LY +   ++ +  +E Q L
Sbjct: 848  QLQEEEDGLQEDQERRRSQEQRRDQKWRWQLEEERKRRRHTLYAKPALQE-QLRKEQQLL 906

Query: 220  QEQQLRSDLLDQYRSLLVERNRSQRYNLYLQHKIFEALRRKKGLEAAEVADR--GAEAEA 277
            QE++      ++ +    E+ R  R    LQ +  + LR ++     +  +R    + + 
Sbjct: 907  QEEEEELQREEREKRRRQEQERQYREEEQLQQEEEQLLREEREKRRRQERERQYRKDKKL 966

Query: 278  PEKEQAYLRHLGMLEELKKQQADDLQWYHQELGQLKRQCQEKLTRVEKEWRRFQALKKQV 337
             +KE+  L      EE +K++  + +  ++E  +L+++ +E+L R E+E RR Q  ++Q 
Sbjct: 967  QQKEEQLLG-----EEPEKRRRQEREKKYREEEELQQE-EEQLLREEREKRRRQEWERQY 1020

Query: 338  VMQAMGSCRMRGGRQAALREVEQIQALEDKKEKEMSAVRLENIQLKQSLVHFETRMRTQE 397
              +      ++   +  LRE  + + L++++ +      L+  Q ++ L+  E   R ++
Sbjct: 1021 RKKD----ELQQEEEQLLREEREKRRLQERERQYREEEELQ--QEEEQLLGEERETRRRQ 1074

Query: 398  DLTQGLL----LIDFEQLKIENQTFNEKIEERNEELLKLRSKVTNSVQVITHVKEKLHFM 453
            +L +       L   E+  +  +    + +ER  +  +         Q++   +EK    
Sbjct: 1075 ELERQYRKEEELQQEEEQLLREEPEKRRRQERERQCREEEELQQEEEQLLREEREKRRRQ 1134

Query: 454  DMENACKKTQLAEIEAQAALGRDILTKTKQAREGLRTDNIRLNQKCGLLGKDSLLRDLEE 513
            ++E   ++ +  + E +  L  +   + +Q  E    +   L Q+     ++ LLR+ +E
Sbjct: 1135 ELERQYREEEEVQQEEEQLLREEPEKRRRQELERQYREEEELQQE-----EEQLLREEQE 1189

Query: 514  K-VDKTELLHRRLESLKR 530
            K   + E  +R  E L+R
Sbjct: 1190 KRRQERERQYREEEELQR 1207



 Score = 69.3 bits (168), Expect = 9e-12
 Identities = 120/525 (22%), Positives = 218/525 (41%), Gaps = 66/525 (12%)

Query: 44  ESEPEEEEEEQAASQGGTAA----DEQAEAPKGLTAAEAAGEEGPGEPGRPAEP---QPE 96
           E E    EEEQ  S  G       DE+    + L      G E   +  R  +    Q E
Sbjct: 182 EREERRAEEEQLQSCKGHETEEFPDEEQLRRRELLELRRKGREEKQQQRRERQDRVFQEE 241

Query: 97  PE------------EPAEVGAEEPAQPEPGAGPEELEAEAGAEELE---QAAEGKEVRFQ 141
            E            E  ++  EEP +       EE   +   +EL    Q  E ++ R +
Sbjct: 242 EEKEWRKRETVLRKEEEKLQEEEPQRQRELQEEEEQLRKLERQELRRERQEEEQQQQRLR 301

Query: 142 ASLPLTRIDEEEAAAAPEAETERVEGEEEDKEETQRDGAESKERDGEGRPAKSQEEGKRL 201
               L R  EEE     E   E+ E  E+ +E  ++     +E   E +  + QEE +R 
Sbjct: 302 REQQLRRKQEEERREQQEERREQQERREQQEERREQQLRREQEERREQQLRREQEEERR- 360

Query: 202 YGRDEFEDLEWSEEVQKLQEQQLRSDLLDQYRSLLVER--NRSQRYNLYLQHKIFEALRR 259
                 + L   +E ++ ++Q  R   L + + L  E+   R Q+     Q +  + LRR
Sbjct: 361 -----EQQLRREQEEERREQQLRREQQLRREQQLRREQQLRREQQLRREQQLRREQQLRR 415

Query: 260 KKGLEAAEVADRGAEAEAPEKEQAYLRHLGMLEELKKQQADDLQWYHQELGQLKRQCQEK 319
           ++ L   +   R  E E  E++    R     + LK++Q +   W  +E  + +R  QE+
Sbjct: 416 EQQLRREQQLRREQEEERHEQKHEQERR---EQRLKREQEERRDWLKRE-EETERHEQER 471

Query: 320 ----LTRVEKEWRRFQALKKQVVMQAMGSCRMRGGRQAALREVEQIQALEDKKEKEMSAV 375
               L R ++E RR + LK +   +          R+   R  +Q++  E ++ +E    
Sbjct: 472 RKQQLKRDQEEERRERWLKLEEEER----------REQQERREQQLRR-EQEERREQRLK 520

Query: 376 RLENIQLKQSLVHFETRMRTQEDLTQGLLLIDFEQLKIENQTFNEKI----EERNEELLK 431
           R E  +  Q  +  E ++R +++  +  LL   E+ ++E +   +++    EER ++LLK
Sbjct: 521 RQEEEERLQQRLRSEQQLRREQEERREQLLKREEEKRLEQERREQRLKREQEERRDQLLK 580

Query: 432 LRSKVTNSVQVITHVKEKLHFMDMENACKKTQLAEIEAQAALGRDILTKTKQAREGLRTD 491
            R +     ++    +E+L     E   K+ ++  +E +    R+   K ++  E  R  
Sbjct: 581 -REEERRQQRLKREQEERL-----EQRLKREEVERLEQEER--REQRLKREEPEEERRQQ 632

Query: 492 NIRLNQKCGLLGKDSLLRDLEEKVD---KTELLHRRLES-LKRHH 532
            ++ +++     +  L R+ +E+ +   K E    RLE  LKR H
Sbjct: 633 LLK-SEEQEERRQQQLRREQQERREQRLKREEEEERLEQRLKREH 676



 Score = 64.3 bits (155), Expect = 3e-10
 Identities = 98/468 (20%), Positives = 195/468 (41%), Gaps = 44/468 (9%)

Query: 98   EEPAEVGAEEPAQPEPGAGPEELEAEAGAEELEQAAEGKEVRFQASLPLTRIDEEEAAAA 157
            EE  E   ++  + +     + L+ E   E LEQ  + +    +    L   ++E+A   
Sbjct: 637  EEQEERRQQQLRREQQERREQRLKREEEEERLEQRLKREHEEERREQELAEEEQEQARER 696

Query: 158  PEAETERVEGEEEDKEETQRDGAESKERDGEGRPAKSQEEGKRLYGRDEFEDLEWSEEVQ 217
             ++   + + + E + + ++    S+ R  EG+  + ++E KR   R    +L+W EE +
Sbjct: 697  IKSRIPKWQWQLESEADARQSKVYSRPRKQEGQRRRQEQEEKR---RRRESELQWQEEER 753

Query: 218  ---KLQEQQLRSDLLDQYRSLLVERNRSQRYNLYLQHKIFEALRRKKGLEAAEVADRGAE 274
               + QE++ R D   Q+++   E++   R  L  +  + E   R+   E  +  ++   
Sbjct: 754  AHRQQQEEEQRRDFTWQWQA--EEKSERGRQRLSARPPLREQRERQLRAEERQQREQRFL 811

Query: 275  AEAPEKEQAYL------RHLGMLEE----LKKQQADDLQWYHQELGQLKRQCQEKLTRVE 324
             E  EKEQ         + L  LEE     ++++A  LQ     L + + + + +  R +
Sbjct: 812  PEEEEKEQRRRQRREREKELQFLEEEEQLQRRERAQQLQEEEDGLQEDQERRRSQEQRRD 871

Query: 325  KEW---------RRFQALKKQVVMQAMGSCRMRGGRQAALREVEQIQALEDKK----EKE 371
            ++W         RR   L  +  +Q     ++R  +Q    E E++Q  E +K    E+E
Sbjct: 872  QKWRWQLEEERKRRRHTLYAKPALQE----QLRKEQQLLQEEEEELQREEREKRRRQEQE 927

Query: 372  MSAVRLENIQLKQSLVHFETRMRTQEDLTQGLLLIDFEQLKIENQTFNEKIEERNEELLK 431
                  E +Q ++  +  E R + +    +     D +  + E Q   E+ E+R  +  +
Sbjct: 928  RQYREEEQLQQEEEQLLREEREKRRRQERERQYRKDKKLQQKEEQLLGEEPEKRRRQERE 987

Query: 432  LRSKVTNSV-----QVITHVKEKLHFMDMENACKKTQLAEIEAQAALGRDILTKTKQARE 486
             + +    +     Q++   +EK    + E   +K    + E +  L  +   +  Q RE
Sbjct: 988  KKYREEEELQQEEEQLLREEREKRRRQEWERQYRKKDELQQEEEQLLREEREKRRLQERE 1047

Query: 487  GLRTDNIRLNQ-KCGLLGKDSLLR---DLEEKVDKTELLHRRLESLKR 530
                +   L Q +  LLG++   R   +LE +  K E L +  E L R
Sbjct: 1048 RQYREEEELQQEEEQLLGEERETRRRQELERQYRKEEELQQEEEQLLR 1095



 Score = 59.3 bits (142), Expect = 9e-09
 Identities = 114/512 (22%), Positives = 209/512 (40%), Gaps = 48/512 (9%)

Query: 42   ELESEPEEEEEEQAASQGGTAADEQAEAPKGLTAAEAAGEEGPGEPGRPAEPQPEP---- 97
            E E +  EEEE Q   +     + +    + L       EE   E  +    +PE     
Sbjct: 1045 ERERQYREEEELQQEEEQLLGEERETRRRQELERQYRKEEELQQEEEQLLREEPEKRRRQ 1104

Query: 98   EEPAEVGAEEPAQPEPGAGPEELEAEAGAEELEQAAEGKEVRFQASLPLTRIDEEEAAAA 157
            E   +   EE  Q E      E   +   +ELE+    +E   Q    L R +E E    
Sbjct: 1105 ERERQCREEEELQQEEEQLLREEREKRRRQELERQYREEEEVQQEEEQLLR-EEPEKRRR 1163

Query: 158  PEAETERVEGEEEDKEETQ--RDGAESKERDGEGRPAKSQE-----EGKRLYGRDEFEDL 210
             E E +  E EE  +EE Q  R+  E + ++ E +  + +E       +R    D+  DL
Sbjct: 1164 QELERQYREEEELQQEEEQLLREEQEKRRQERERQYREEEELQRQKRKQRYRDEDQRSDL 1223

Query: 211  EWSEEVQKLQEQQLRSDLL-------DQYRSLLVERNRSQRYNLYLQHKIFEALRRKKGL 263
            +W  E +K  E  +R + +       +Q+R L   + R ++    LQH + E   R +  
Sbjct: 1224 KWQWEPEK--ENAVRDNKVYCKGRENEQFRQLEDSQLRDRQSQQDLQHLLGEQQERDREQ 1281

Query: 264  EAAEVADRGAEAEAPEKEQAYLRHLGMLEELKKQQADDLQWYHQELGQLKRQCQEKLTRV 323
            E      R  +   PE+EQ        LE  ++++A       QE  QL R+ +E+  R 
Sbjct: 1282 ERRRWQQR--DRHFPEEEQ--------LEREEQKEAKRRDRKSQEEKQLLREEREEKRRR 1331

Query: 324  EKEWRRFQALKKQVVMQAMGSCRMRGGRQAALREVEQIQALEDKKEKEMSAVRLENIQLK 383
            ++  R+F+  ++Q++ +       R  R    RE E+++  E  ++      RL   + +
Sbjct: 1332 QETDRKFRE-EEQLLQEREEQPLRRQERDRKFRE-EELRHQEQGRKFLEEEQRLRRQERE 1389

Query: 384  QSLVHFETRMRTQEDLTQGLLLID----FEQLKIENQTFNEKIEERNEELLKLRSKVTNS 439
            +  +  E ++R QE   Q     D     E+ ++  Q  + K  E  E+ ++ + +    
Sbjct: 1390 RKFLKEEQQLRCQEREQQLRQDRDRKFREEEQQLSRQERDRKFRE-EEQQVRRQERERKF 1448

Query: 440  VQVITHVKEKLH--FMDMENACKKTQLAEIEAQAALGRDILTKTKQAREGLRTDNIRLNQ 497
            ++    ++++ H  F + E   ++ +  ++  Q    R  L + +Q R   R    R  +
Sbjct: 1449 LEEEQQLRQERHRKFREEEQLLQEREEQQLHRQER-DRKFLEEEQQLRRQERDRKFREQE 1507

Query: 498  KCGLLGKDSLLRDLEEKVDKTELLHRRLESLK 529
               L  ++   + LEE+    + LHR+    K
Sbjct: 1508 ---LRSQEPERKFLEEE----QQLHRQQRQRK 1532



 Score = 58.2 bits (139), Expect = 2e-08
 Identities = 92/440 (20%), Positives = 189/440 (42%), Gaps = 47/440 (10%)

Query: 147 TRIDEEEAAAAPEAETERVEG-EEEDKEETQRDGAESKERDGEGRPAKSQEEGKRLYGRD 205
           T +DEE+ A     E+   +  +EED+   +    + +E  G+ R  K QE+ + L   +
Sbjct: 93  TGLDEEKRARCDGKESLLQDRRQEEDQRRFEPRDRQLEEEPGQRRRQKRQEQERELAEGE 152

Query: 206 EFED---------------------LEWSE-EVQKLQEQQLRSDLLDQYRSLLVERNRSQ 243
           E  +                      EW E E ++ +E+QL+S    +      E    +
Sbjct: 153 EQSEKQERLEQRDRQRRDEELWRQRQEWQEREERRAEEEQLQSCKGHETEEFPDEEQLRR 212

Query: 244 RYNLYLQHKIFEALRRKKGLEAAEVADRGAEAEAPEKEQAYLRHLGMLEELKKQQADDLQ 303
           R  L L+ K  E  ++++      V     E E  ++E    +    L+E + Q+  +LQ
Sbjct: 213 RELLELRRKGREEKQQQRRERQDRVFQEEEEKEWRKRETVLRKEEEKLQEEEPQRQRELQ 272

Query: 304 WYHQELGQLKRQ----------CQEKLTRVEKEWRRFQALKKQVVMQAMGSCRMRGGRQA 353
              ++L +L+RQ           Q++  R E++ RR Q  +++   +     + R  +Q 
Sbjct: 273 EEEEQLRKLERQELRRERQEEEQQQQRLRREQQLRRKQEEERREQQEERREQQERREQQE 332

Query: 354 ALREVEQIQALEDKKEKEM-----SAVRLENIQLKQSLVHFETRMRTQEDLTQGLLLIDF 408
             RE +  +  E+++E+++        R + ++ +Q     E ++R ++ L +   L   
Sbjct: 333 ERREQQLRREQEERREQQLRREQEEERREQQLRREQEEERREQQLRREQQLRREQQLRRE 392

Query: 409 EQLKIENQTFNEKIEERNEELLKLRSKVTNSVQVITHVKEKLHFMDMENACKKTQL--AE 466
           +QL+ E Q   E+ + R E+ L+   ++    Q+    +E+ H    E   ++ +L   +
Sbjct: 393 QQLRREQQLRREQ-QLRREQQLRREQQLRREQQLRREQEEERHEQKHEQERREQRLKREQ 451

Query: 467 IEAQAALGRDILT---KTKQAREGLRTDNIRLNQKCGLLGKDSLLRDLEEKVD---KTEL 520
            E +  L R+  T   + ++ ++ L+ D     ++  L  ++   R+ +E+ +   + E 
Sbjct: 452 EERRDWLKREEETERHEQERRKQQLKRDQEEERRERWLKLEEEERREQQERREQQLRREQ 511

Query: 521 LHRRLESLKRHHASLTLSCR 540
             RR + LKR      L  R
Sbjct: 512 EERREQRLKRQEEEERLQQR 531



 Score = 58.2 bits (139), Expect = 2e-08
 Identities = 119/542 (21%), Positives = 227/542 (41%), Gaps = 56/542 (10%)

Query: 43   LESEPEEEEEEQAASQGGTAADEQAEAPKGLTAAEAAGEEGPGEPGRPAEPQ--PEPEEP 100
            L+ E EE  E+Q   +     +++    + L   E   EE   +    +E Q   E EE 
Sbjct: 489  LKLEEEERREQQERREQQLRREQEERREQRLKRQE---EEERLQQRLRSEQQLRREQEER 545

Query: 101  AE--VGAEEPAQPEPGAGPEELEAEAGAEELEQAAEGKEVRFQASLPLTRIDEEEAAAAP 158
             E  +  EE  + E     + L+ E   E  +Q  + +E R Q  L   + +  E     
Sbjct: 546  REQLLKREEEKRLEQERREQRLKREQ-EERRDQLLKREEERRQQRLKREQEERLEQRLKR 604

Query: 159  EAETERVEGEEEDKEETQRDGAESKERD----GEGRPAKSQEEGKRLYGRDEFEDLEWSE 214
            E E ER+E EE  ++  +R+  E + R      E +  + Q++ +R       + L+  E
Sbjct: 605  E-EVERLEQEERREQRLKREEPEEERRQQLLKSEEQEERRQQQLRREQQERREQRLKREE 663

Query: 215  EVQKLQEQQLRSDLLDQYRSLLVERNRSQRYNLYLQHKIFEALRRKKGLEAAEVADRGAE 274
            E ++L+++  R    ++    L E  + Q      + +I   + + +    +E   R ++
Sbjct: 664  EEERLEQRLKREHEEERREQELAEEEQEQA-----RERIKSRIPKWQWQLESEADARQSK 718

Query: 275  AEAPEKEQAYLRHLGMLEELKKQQADDLQWYHQELGQLKRQCQEKLTRVEKEWRRFQALK 334
              +  ++Q   R     EE ++++  +LQW  +E  +  RQ QE+  R +  W ++QA +
Sbjct: 719  VYSRPRKQEGQRRRQEQEEKRRRRESELQWQEEE--RAHRQQQEEEQRRDFTW-QWQAEE 775

Query: 335  KQVVMQAMGSCR--MRGGRQAALREVEQIQA----LEDKKEKE----MSAVRLENIQLKQ 384
            K    +   S R  +R  R+  LR  E+ Q     L +++EKE        R + +Q  +
Sbjct: 776  KSERGRQRLSARPPLREQRERQLRAEERQQREQRFLPEEEEKEQRRRQRREREKELQFLE 835

Query: 385  SLVHFETRMRTQE-DLTQGLLLIDFEQLKIENQTFNEKIEERNEELLK-----------L 432
                 + R R Q+    +  L  D E+ + + Q  ++K   + EE  K           L
Sbjct: 836  EEEQLQRRERAQQLQEEEDGLQEDQERRRSQEQRRDQKWRWQLEEERKRRRHTLYAKPAL 895

Query: 433  RSKVTNSVQVITHVKEKL--------HFMDMENACKKTQLAEIEAQAALGRDILTKTKQA 484
            + ++    Q++   +E+L           + E   ++ +  + E +  L  +   + +Q 
Sbjct: 896  QEQLRKEQQLLQEEEEELQREEREKRRRQEQERQYREEEQLQQEEEQLLREEREKRRRQE 955

Query: 485  REGLRTDNIRLNQK-CGLLGKDSLLRDLEEKVDKTELLHRRLESLKRHHASLTLSCRGVR 543
            RE     + +L QK   LLG++   R  +E+  K    +R  E L++    L    R  R
Sbjct: 956  RERQYRKDKKLQQKEEQLLGEEPEKRRRQEREKK----YREEEELQQEEEQLLREEREKR 1011

Query: 544  QK 545
            ++
Sbjct: 1012 RR 1013



 Score = 48.9 bits (115), Expect = 1e-05
 Identities = 74/329 (22%), Positives = 143/329 (43%), Gaps = 30/329 (9%)

Query: 121  EAEAGAEELEQAAEGKEVRFQASLPLTRIDEEEAAAAPEAETERVEGEEEDK----EETQ 176
            E E    E EQ    +E + Q      R   E+     E E +++  +E D+    EE Q
Sbjct: 1592 EQERKFMEDEQQLRRQEGQQQLRQERDRKFREDEQLLQEREEQQLHRQERDRKFLEEEPQ 1651

Query: 177  RDGAESKERDGEGRPAKSQEEGKRLYGRDEFEDLEWSEEVQKLQEQQLRSDLLDQYRSLL 236
                E +++    R  K +EE ++L    E + L   E  +K +E++ +    ++ R  L
Sbjct: 1652 LRRQEREQQLRHDRDRKFREE-EQLLQEGEEQQLRRQERDRKFREEEQQLRRQERERKFL 1710

Query: 237  VERNRSQRYNLYLQHKIFEALRRKKGLEAAEVADR-----GAEAEAPEKEQAYLRHLGML 291
             E  + +R  L  + +  E LR++   E     +R       E   PE+E+  LR     
Sbjct: 1711 QEEQQLRRQELERKFREEEQLRQETEQEQLRRQERYRKILEEEQLRPEREEQQLRR---Q 1767

Query: 292  EELKKQQADDLQWYHQELGQLKRQCQEKLTRVEKEWRRFQALKKQVVMQAMGSCRMRGGR 351
            E  +K + ++     +E  QL+ Q  ++  R E++ R+ +  ++    Q  G  R     
Sbjct: 1768 ERDRKFREEEQLRQEREEQQLRSQESDRKFREEEQLRQEREEQQLRPQQRDGKYRW---E 1824

Query: 352  QAALREVEQIQALEDKKEK-----EMSAVRLENIQLKQSLVHFETRMRTQEDLTQGLLLI 406
            +  L+  EQ Q L  ++++     E  A + ++ + +Q L   E + R QE         
Sbjct: 1825 EEQLQLEEQEQRLRQERDRQYRAEEQFATQEKSRREEQELWQEEEQKRRQE--------- 1875

Query: 407  DFEQLKIENQTFNEKIEERNEELLKLRSK 435
               +L+ E+    +K E+R+ ++ +++S+
Sbjct: 1876 RERKLREEHIRRQQKEEQRHRQVGEIKSQ 1904



 Score = 44.7 bits (104), Expect = 2e-04
 Identities = 54/219 (24%), Positives = 92/219 (42%), Gaps = 38/219 (17%)

Query: 110  QPEPGAGPEELEAEAGAEE-LEQAAEGKEVRFQASLPLTRIDEEEAAAAPEAETERVEGE 168
            Q E     +ELE +   EE L Q  E +++R Q      R   EE    PE E +++  +
Sbjct: 1711 QEEQQLRRQELERKFREEEQLRQETEQEQLRRQERY---RKILEEEQLRPEREEQQLRRQ 1767

Query: 169  EEDK------------EETQRDGAESKERDGEGRPAKSQEEGKRLYGRDEFEDLEWSEEV 216
            E D+            EE Q    ES  +  E    + + E ++L  +       W EE 
Sbjct: 1768 ERDRKFREEEQLRQEREEQQLRSQESDRKFREEEQLRQEREEQQLRPQQRDGKYRWEEEQ 1827

Query: 217  QKLQEQQLRSDLLDQYRSLLVERNRSQRYNLYLQHKIFEALRRKKGLEAAEVADRGAEAE 276
             +L+EQ+              +R R +R   Y   + F A + K   E  E+     +  
Sbjct: 1828 LQLEEQE--------------QRLRQERDRQYRAEEQF-ATQEKSRREEQELWQEEEQKR 1872

Query: 277  APEKEQAYLRHLGMLEELKKQQADDLQWYHQELGQLKRQ 315
              E+E+  LR     E +++QQ ++ +  H+++G++K Q
Sbjct: 1873 RQERERK-LRE----EHIRRQQKEEQR--HRQVGEIKSQ 1904



 Score = 44.3 bits (103), Expect = 3e-04
 Identities = 86/413 (20%), Positives = 166/413 (40%), Gaps = 69/413 (16%)

Query: 118  EELEAEAGAEELEQAAEGKEVRFQASLPLTRIDEEEAAAAPEAETERVEGEEEDKEETQR 177
            +E + +   EE +   + +E +F       R  +E      E E    E EE+     +R
Sbjct: 1426 QERDRKFREEEQQVRRQERERKFLEEEQQLR--QERHRKFREEEQLLQEREEQQLHRQER 1483

Query: 178  DGAESKERDGEGRPAKSQEEGKRLYGRDEFEDLEWSEEVQKLQEQQLRSDLLDQYRSLLV 237
            D           R    +E+  R   RD           +K +EQ+LRS   +  R  L 
Sbjct: 1484 D-----------RKFLEEEQQLRRQERD-----------RKFREQELRSQ--EPERKFLE 1519

Query: 238  ER---NRSQRYNLYLQHKIFEALRRKKGLEAAEVADRGAEAEAPEKEQAYLRHLGMLEEL 294
            E    +R QR   +LQ +  +  R+++G +  +  DR                    EE 
Sbjct: 1520 EEQQLHRQQRQRKFLQEE-QQLRRQERGQQRRQDRDRKFRE----------------EEQ 1562

Query: 295  KKQQADDLQWYHQELGQLKRQCQEKLTRVEKEWRRFQALKKQVVMQAMGSCRMRGGRQAA 354
             +Q+ ++ Q   QE  +  R  ++K+ R E+E R+F   ++Q+  Q  G  ++R  R   
Sbjct: 1563 LRQEREEQQLSRQERDRKFRLEEQKVRRQEQE-RKFMEDEQQLRRQE-GQQQLRQERDRK 1620

Query: 355  LREVEQIQALEDKKEKEM-----------SAVRLENIQLKQSLVHFETRMRTQEDLTQGL 403
             RE EQ+  L++++E+++              +L   + +Q L H   R   +E+     
Sbjct: 1621 FREDEQL--LQEREEQQLHRQERDRKFLEEEPQLRRQEREQQLRHDRDRKFREEE----Q 1674

Query: 404  LLIDFEQLKIENQTFNEKIEERNEELLK--LRSKVTNSVQVITHVKEKLHFMDMENACKK 461
            LL + E+ ++  Q  + K  E  ++L +     K     Q +   + +  F + E   ++
Sbjct: 1675 LLQEGEEQQLRRQERDRKFREEEQQLRRQERERKFLQEEQQLRRQELERKFREEEQLRQE 1734

Query: 462  TQLAEIEAQAALGRDILTKTKQAREGLRTDNIRLNQKCGLLGKDSLLRDLEEK 514
            T+  ++  Q    +  + + +Q R       +R  ++     ++  LR   E+
Sbjct: 1735 TEQEQLRRQERYRK--ILEEEQLRPEREEQQLRRQERDRKFREEEQLRQEREE 1785



 Score = 35.4 bits (80), Expect = 0.14
 Identities = 67/324 (20%), Positives = 129/324 (39%), Gaps = 25/324 (7%)

Query: 120  LEAEAGAEELEQAAEGKEVRFQASLPLTRIDEEEAAAAPEAETERVEGEEEDKEETQRDG 179
            LE E      E+  + +E   ++  P  +  EEE     +    +   EE+     +R  
Sbjct: 1488 LEEEQQLRRQERDRKFREQELRSQEPERKFLEEEQQLHRQQRQRKFLQEEQQLRRQERGQ 1547

Query: 180  AESKERDGEGRPAKS--QEEGKRLYGRDEFEDLEWSEEVQKLQEQQLRSDLLDQYRSLLV 237
               ++RD + R  +   QE  ++   R E  D ++  E QK++ Q+     ++  + L  
Sbjct: 1548 QRRQDRDRKFREEEQLRQEREEQQLSRQE-RDRKFRLEEQKVRRQEQERKFMEDEQQLRR 1606

Query: 238  ERN----RSQRYNLYLQHKIFEALRRKKGLEAAEVADRGAEAEAPEKEQAYLRHLGMLEE 293
            +      R +R   + + +     R ++ L   E   +  E E   + Q   + L    +
Sbjct: 1607 QEGQQQLRQERDRKFREDEQLLQEREEQQLHRQERDRKFLEEEPQLRRQEREQQLRHDRD 1666

Query: 294  LKKQQADDLQWYHQELGQLKRQCQEKLTRVEKEWRRFQALKKQVVMQAMGSCRMRGGRQA 353
             K ++ + L    +E    +++   K    E++ RR +  +K   +Q     R R   + 
Sbjct: 1667 RKFREEEQLLQEGEEQQLRRQERDRKFREEEQQLRRQERERK--FLQEEQQLR-RQELER 1723

Query: 354  ALREVEQI-QALEDKKEKEMSAVR--LENIQLK-----QSLVHFE--TRMRTQEDLTQGL 403
              RE EQ+ Q  E ++ +     R  LE  QL+     Q L   E   + R +E L Q  
Sbjct: 1724 KFREEEQLRQETEQEQLRRQERYRKILEEEQLRPEREEQQLRRQERDRKFREEEQLRQ-- 1781

Query: 404  LLIDFEQLKIENQTFNEKIEERNE 427
               + E+ ++ +Q  + K  E  +
Sbjct: 1782 ---EREEQQLRSQESDRKFREEEQ 1802


>gi|41322923 plectin 1 isoform 11 [Homo sapiens]
          Length = 4547

 Score = 75.1 bits (183), Expect = 2e-13
 Identities = 121/511 (23%), Positives = 206/511 (40%), Gaps = 85/511 (16%)

Query: 50   EEEEQAASQGGTAADEQAEAPKGLTAAEAAGEE----GPGEPGRPAEPQPEPEEPAEVGA 105
            EEEE+ A Q      ++AE  + L   EAA E+            A+ + E +E  +   
Sbjct: 1345 EEEERLAEQ------QRAEERERLAEVEAALEKQRQLAEAHAQAKAQAEREAKELQQRMQ 1398

Query: 106  EEPAQPEPGAGPEELEAEAGAEELEQAAEGKEVRFQASLPLTRIDEEEAAAAPEAETERV 165
            EE  + E  A   + +  +  EEL+Q  +  E   QA          +A  A  AE  R+
Sbjct: 1399 EEVVRREEAAVDAQQQKRSIQEELQQLRQSSEAEIQA----------KARQAEAAERSRL 1448

Query: 166  EGEEE--------DKEETQRDGAE-------SKERDGEGRPAKSQEEGKRL--YGRDEFE 208
              EEE        +  E QR GAE       ++  + E +  ++QEE +RL    +DE +
Sbjct: 1449 RIEEEIRVVRLQLEATERQRGGAEGELQALRARAEEAEAQKRQAQEEAERLRRQVQDESQ 1508

Query: 209  DLEWSE---------EVQKLQEQQLRSDLLDQYRSLLVERNRSQRYNLYLQHKIFEALRR 259
                +E         E +  +E+Q     L++ R    E  R  R          E  R 
Sbjct: 1509 RKRQAEVELASRVKAEAEAAREKQRALQALEELRLQAEEAERRLRQ--------AEVERA 1560

Query: 260  KKGLEAAEVADRGAEAEAPEKEQAYLRHLGMLEELKKQQADDLQWYHQELGQLKRQCQEK 319
            ++   A E A R AEAE   K  ++      LE         LQ  H  + QL+ + + +
Sbjct: 1561 RQVQVALETAQRSAEAELQSKRASFAEKTAQLER-------SLQEEHVAVAQLREEAERR 1613

Query: 320  L-TRVEKEWRRFQALKK----QVVMQAMGSCRMRGGRQAALREVEQIQALEDKKEKEMSA 374
               + E E  R +A ++    Q+        R++    A  + + Q +A + K+E E  A
Sbjct: 1614 AQQQAEAERAREEAERELERWQLKANEALRLRLQAEEVAQQKSLAQAEAEKQKEEAEREA 1673

Query: 375  VRLENIQLKQSLVHFETRMRTQEDLTQGLLLIDFEQLKIENQTFNEKIEERNEELLKLRS 434
             R    +        E  +R +E   Q L     +Q ++   T  +++    +EL++LR+
Sbjct: 1674 RRRGKAE--------EQAVRQRELAEQEL----EKQRQLAEGTAQQRL-AAEQELIRLRA 1720

Query: 435  KVTNSVQVITHVKEKLHFMDMENACKKTQLAEIEAQAALGRD----ILTKTKQAREGLRT 490
            +     Q    ++E+L  +  E A    +  E+EA+ A  R     +L    +A E  R+
Sbjct: 1721 ETEQGEQQRQLLEEELARLQREAAAATQKRQELEAELAKVRAEMEVLLASKARAEEESRS 1780

Query: 491  DNIRLNQKCGLLGKDSLLRDLEEKVDKTELL 521
             + +  Q+  L  +    R+L E+  +   L
Sbjct: 1781 TSEKSKQR--LEAEAGRFRELAEEAARLRAL 1809



 Score = 62.8 bits (151), Expect = 8e-10
 Identities = 99/447 (22%), Positives = 172/447 (38%), Gaps = 70/447 (15%)

Query: 119  ELEA----EAGAEELEQAAEGKEVRFQASLPLTRIDEEEAAAAPEAETERVEGEEEDKEE 174
            ELEA    +  AEE  +  E +E R Q SL      EEEAA   +A  E VE  +   EE
Sbjct: 1966 ELEAARQRQLAAEEERRRREAEE-RVQKSLAA----EEEAARQRKAALEEVERLKAKVEE 2020

Query: 175  TQRDGAESKERDGEGRPAKSQEEGKRLYGRDEFEDLEWSEEVQKLQEQ-QLRSDLLDQYR 233
             +R    +++          +   KRL   ++       ++ Q+LQ+  Q    +LDQ R
Sbjct: 2021 ARRLRERAEQESARQLQLAQEAAQKRLQAEEKAHAFAVQQKEQELQQTLQQEQSVLDQLR 2080

Query: 234  SLLVERNRSQRYNLYLQHKIFEALRRKKGLEAAEVADRGAEAEAPEKEQAYLRHLGMLEE 293
                                 EA   ++  E AE A   AE EA +  +           
Sbjct: 2081 G--------------------EAEAARRAAEEAEEARVQAEREAAQSRR----------- 2109

Query: 294  LKKQQADDLQWYHQELGQLKRQCQEKLTRVEKEWRRFQALKKQVVMQAMGSCRMRGGRQA 353
             + ++A+ L+   +E  Q + Q Q    ++ KE  +  A + Q               QA
Sbjct: 2110 -QVEEAERLKQSAEEQAQARAQAQAAAEKLRKEAEQEAARRAQ-------------AEQA 2155

Query: 354  ALREVEQIQALEDKKEKEMSAVRLENIQLKQSLVHFETRMRTQEDLTQGLLLIDFEQLK- 412
            ALR+ +   A  +K +K       +  Q++Q L     ++  + D  + LL  + ++LK 
Sbjct: 2156 ALRQKQAADAEMEKHKKFAEQTLRQKAQVEQELTTLRLQLE-ETDHQKNLLDEELQRLKA 2214

Query: 413  -----------IENQTFNEKIEERNEELLKLRSKVTNSVQVITHVKEKLHFMDMENACKK 461
                       +E + F+ +++      LK R +  N   ++        F+  E A K 
Sbjct: 2215 EATEAARQRSQVEEELFSVRVQMEELSKLKARIEAENRALILRDKDNTQRFL-QEEAEKM 2273

Query: 462  TQLAEIEAQAALGRDILTKTKQAREGLRTDNIRLNQKCGLLGKDSLLRDLEEKVDKTELL 521
             Q+AE  A+ ++      + +Q  E        L +K  L  K   +++      + ELL
Sbjct: 2274 KQVAEEAARLSVAAQEAARLRQLAEEDLAQQRALAEKM-LKEKMQAVQEATRLKAEAELL 2332

Query: 522  HRRLESLKRHHASLTLSCRGVRQKIRE 548
             ++ E  +     L      + Q++ E
Sbjct: 2333 QQQKELAQEQARRLQEDKEQMAQQLAE 2359



 Score = 62.8 bits (151), Expect = 8e-10
 Identities = 114/528 (21%), Positives = 218/528 (41%), Gaps = 53/528 (10%)

Query: 43   LESEPEEEEEEQAASQGGTAADEQAEAPKGLTAAEAAGEEGPGEPG----RPAEPQPEPE 98
            L+ E    ++ +  ++    A E+AE  +     EAA      E      + AE Q +  
Sbjct: 2069 LQQEQSVLDQLRGEAEAARRAAEEAEEARVQAEREAAQSRRQVEEAERLKQSAEEQAQAR 2128

Query: 99   EPAEVGAEEPAQPEPGAGPEELEAEAGAEELEQAAEGKEVRFQASLPLTRIDEEEAAAAP 158
              A+  AE+  +          +AE  A   +QAA+ +  + +     T    ++A    
Sbjct: 2129 AQAQAAAEKLRKEAEQEAARRAQAEQAALRQKQAADAEMEKHKKFAEQTL--RQKAQVEQ 2186

Query: 159  EAETERVEGEEEDKEETQRDGAESKERDGEGRPAKSQEEGKRLYGRDEFEDLEWSEEVQK 218
            E  T R++ EE D ++   D  E +    E   A  Q        R + E+  +S  VQ 
Sbjct: 2187 ELTTLRLQLEETDHQKNLLD-EELQRLKAEATEAARQ--------RSQVEEELFSVRVQM 2237

Query: 219  LQEQQLRSDLLDQYRSLLV-ERNRSQRYNLYLQHKIFEALRRKKGLEAAEVADRGAEAEA 277
             +  +L++ +  + R+L++ +++ +QR   +LQ    EA + K      +VA+  A    
Sbjct: 2238 EELSKLKARIEAENRALILRDKDNTQR---FLQE---EAEKMK------QVAEEAARLSV 2285

Query: 278  PEKEQAYLRHLGMLEELKKQQA------DDLQWYHQELGQLKRQC---QEKLTRVEKEWR 328
              +E A LR L   E+L +Q+A       +     QE  +LK +    Q++    +++ R
Sbjct: 2286 AAQEAARLRQLAE-EDLAQQRALAEKMLKEKMQAVQEATRLKAEAELLQQQKELAQEQAR 2344

Query: 329  RFQALKKQVVMQAMGSCRMRGGRQAALREVEQIQALEDKKEKEMSAVRLENIQLKQSLVH 388
            R Q  K+Q+  Q     +   G Q  L E E+ + LE   E E   +R+  +   Q+   
Sbjct: 2345 RLQEDKEQMAQQLAEETQ---GFQRTL-EAERQRQLEMSAEAERLKLRVAEMSRAQARAE 2400

Query: 389  FETRMRTQEDLTQGLLLIDFEQLKIENQTFNEKIEERNEELLKLRSKVTNSVQVITHVKE 448
             + +   ++    G  L   E    E  T  + +E + ++      ++  ++  +   KE
Sbjct: 2401 EDAQRFRKQAEEIGEKLHRTELATQEKVTLVQTLEIQRQQSDHDAERLREAIAELEREKE 2460

Query: 449  KLHFMDMENACKKTQLAEIEAQAALGRDILTKTKQAREGLRTDNIRLNQKCGLL--GKDS 506
            KL     +   K  QL   E Q      +L +T+  ++   ++   L Q+   +   K  
Sbjct: 2461 KL-----QQEAKLLQLKSEEMQTVQQEQLLQETQALQQSFLSEKDSLLQRERFIEQEKAK 2515

Query: 507  LLRDLEEKVDKTELL----HRRLESLKRHHASLTLSCRGVRQKIREAK 550
            L +  +++V K + L     R+ + +++    L  S    R++  EA+
Sbjct: 2516 LEQLFQDEVAKAQQLREEQQRQQQQMEQERQRLVASMEEARRRQHEAE 2563



 Score = 57.8 bits (138), Expect = 3e-08
 Identities = 120/542 (22%), Positives = 227/542 (41%), Gaps = 76/542 (14%)

Query: 43   LESEPEEEEEEQAASQGGTAADEQAEAPKGLTAAEAAGEEGPGEPG-RPAEPQPEPEEPA 101
            L+ EP  E  ++ A Q    A+ +    KG+    A  E+    P   PA P    E   
Sbjct: 1011 LDKEPARECAQRIAEQQKAQAEVEGLG-KGVARLSAEAEKVLALPEPSPAAPTLRSELEL 1069

Query: 102  EVGAEEPAQPEPGAGPEELEAEA-------GAEELEQAAEGKEVRFQASLPLTRIDEEEA 154
             +G  E  +       E+L+  +       GAEE+ +A E ++++   ++P T  + E  
Sbjct: 1070 TLGKLEQVRSLSAIYLEKLKTISLVIRGTQGAEEVLRAHE-EQLKEAQAVPATLPELE-- 1126

Query: 155  AAAPEAETERVEGEEEDKEETQRDGAESKERDGEGRPAKSQEEGKRLYGRDEFEDLE--- 211
              A +A  +++  + E ++ T  D    + R        +QE G+RL  R    D+E   
Sbjct: 1127 --ATKASLKKLRAQAEAQQPTF-DALRDELRG-------AQEVGERLQQRHGERDVEVER 1176

Query: 212  WSEEVQKLQEQ--------QLRSDLLDQY-RSLLVERNRSQRYNLYLQHKIFEALRRKKG 262
            W E V +L E+         +R   L+Q  R L   R  +     +LQ    +A RR++ 
Sbjct: 1177 WRERVAQLLERWQAVLAQTDVRQRELEQLGRQLRYYRESADPLGAWLQ----DARRRQEQ 1232

Query: 263  LEAAEVADRGAEAEAPEKEQAYL----RHLGMLEELK---KQQADDLQWYHQELGQLKRQ 315
            ++A  +AD  A  E   +EQA L    RH   +EE +   KQ  + ++ Y  +L   K Q
Sbjct: 1233 IQAMPLADSQAVREQLRQEQALLEEIERHGEKVEECQRFAKQYINAIKDYELQLVTYKAQ 1292

Query: 316  CQEKLTRVEKEWRRFQALKKQVVMQAMGSCRMRGGRQAAL--REVEQIQALEDKKEKEMS 373
             +   +  +K   + Q+  + V+ + +   R        L  + ++ I     + E+E  
Sbjct: 1293 LEPVASPAKKP--KVQSGSESVIQEYV-DLRTHYSELTTLTSQYIKFISETLRRMEEEER 1349

Query: 374  AVRLENIQLKQSLVHFETRMRTQEDLTQGLLLIDFEQLKIENQTFNEKIEER-NEELLKL 432
                +  + ++ L   E  +  Q  L +        Q K + +   +++++R  EE+++ 
Sbjct: 1350 LAEQQRAEERERLAEVEAALEKQRQLAEA-----HAQAKAQAEREAKELQQRMQEEVVRR 1404

Query: 433  RSKVTNSVQVITHVKEKLHFMDMENACKKTQLAEIEAQAALGRDILTKTKQAREGLRTDN 492
                 ++ Q    ++E+L  +      +++  AEI+A+A           +  E +R   
Sbjct: 1405 EEAAVDAQQQKRSIQEELQQL------RQSSEAEIQAKARQAEAAERSRLRIEEEIRVVR 1458

Query: 493  IRL----NQKCGLLGKDSLLRDLEEKV--------DKTELLHRRL--ESLKRHHASLTLS 538
            ++L     Q+ G  G+   LR   E+         ++ E L R++  ES ++  A + L+
Sbjct: 1459 LQLEATERQRGGAEGELQALRARAEEAEAQKRQAQEEAERLRRQVQDESQRKRQAEVELA 1518

Query: 539  CR 540
             R
Sbjct: 1519 SR 1520



 Score = 45.8 bits (107), Expect = 1e-04
 Identities = 86/441 (19%), Positives = 169/441 (38%), Gaps = 32/441 (7%)

Query: 42   ELESEPEEEEEEQAASQGGTAADEQAEAPKGLTAAEAAGEEGPGEPGRPAEPQPEPEEPA 101
            + E+E ++EE E+ A + G A +EQA   + L   E   +    E G   +     +E  
Sbjct: 1659 QAEAEKQKEEAEREARRRGKA-EEQAVRQRELAEQELEKQRQLAE-GTAQQRLAAEQELI 1716

Query: 102  EVGAE-EPAQPEPGAGPEEL---EAEAGA-----EELEQAAEGKEVRFQASLPLTRIDEE 152
             + AE E  + +     EEL   + EA A     +ELE          +  L      EE
Sbjct: 1717 RLRAETEQGEQQRQLLEEELARLQREAAAATQKRQELEAELAKVRAEMEVLLASKARAEE 1776

Query: 153  EAAAAPEAETERVEGEEEDKEETQRDGAESKERDGEGRPAKSQEEGKRLYGRDEFEDLEW 212
            E+ +  E   +R+E E     E   + A         R     EE KR          + 
Sbjct: 1777 ESRSTSEKSKQRLEAEAGRFRELAEEAA---------RLRALAEEAKR--------QRQL 1819

Query: 213  SEEVQKLQEQQLRSDLLDQYRSLLVERNRSQRYNLYLQHKIFEALRRKKGLEAAEVADRG 272
            +EE    Q  +    L ++  ++           + L+ K  E  R ++  E      R 
Sbjct: 1820 AEEDAARQRAEAERVLAEKLAAIGEATRLKTEAEIALKEKEAENERLRRLAEDEAFQRRR 1879

Query: 273  AEAEAPEKEQAYLRHLGMLEELKKQQADDLQWYHQELGQLKRQCQEKLTRVEKEWRRFQA 332
             E +A + +      L  L +    + +  +   ++  + +RQ +E++  ++  + +  A
Sbjct: 1880 LEEQAAQHKADIEERLAQLRKASDSELERQKGLVEDTLRQRRQVEEEILALKASFEKAAA 1939

Query: 333  LKKQVVMQAMGSCRMRGGRQAALREVEQIQALEDKKEKEMSAVRLENIQLKQSLVHFETR 392
             K ++ ++ +G  R+R   +  LR  EQ + LE  ++++++A      +  +  V     
Sbjct: 1940 GKAELELE-LG--RIRSNAEDTLRSKEQAE-LEAARQRQLAAEEERRRREAEERVQKSLA 1995

Query: 393  MRTQEDLTQGLLLIDFEQLKIENQTFNEKIEERNEELLKLRSKVTNSVQVITHVKEKLHF 452
               +    +   L + E+LK + +      E   +E  +       + Q     +EK H 
Sbjct: 1996 AEEEAARQRKAALEEVERLKAKVEEARRLRERAEQESARQLQLAQEAAQKRLQAEEKAHA 2055

Query: 453  MDMENACKKTQLAEIEAQAAL 473
              ++   ++ Q    + Q+ L
Sbjct: 2056 FAVQQKEQELQQTLQQEQSVL 2076



 Score = 32.3 bits (72), Expect = 1.2
 Identities = 27/102 (26%), Positives = 54/102 (52%), Gaps = 9/102 (8%)

Query: 141  QASLPLTRIDEEEAAAAPEAETERVEGEEEDKEETQR-----DGAESKERDGEGRPAKSQ 195
            Q    L ++ ++E A A +   E+   +++ ++E QR     + A  ++ + E    + Q
Sbjct: 2511 QEKAKLEQLFQDEVAKAQQLREEQQRQQQQMEQERQRLVASMEEARRRQHEAEEGVRRKQ 2570

Query: 196  EEGKRLYGRDEFEDLEWSEEVQKLQEQ-QLRSDLLDQYRSLL 236
            EE ++L  +   ++   +EE Q+L+EQ QL   L +Q+R+ L
Sbjct: 2571 EELQQLEQQRRQQEELLAEENQRLREQLQL---LEEQHRAAL 2609


>gi|41322914 plectin 1 isoform 10 [Homo sapiens]
          Length = 4551

 Score = 75.1 bits (183), Expect = 2e-13
 Identities = 121/511 (23%), Positives = 206/511 (40%), Gaps = 85/511 (16%)

Query: 50   EEEEQAASQGGTAADEQAEAPKGLTAAEAAGEE----GPGEPGRPAEPQPEPEEPAEVGA 105
            EEEE+ A Q      ++AE  + L   EAA E+            A+ + E +E  +   
Sbjct: 1349 EEEERLAEQ------QRAEERERLAEVEAALEKQRQLAEAHAQAKAQAEREAKELQQRMQ 1402

Query: 106  EEPAQPEPGAGPEELEAEAGAEELEQAAEGKEVRFQASLPLTRIDEEEAAAAPEAETERV 165
            EE  + E  A   + +  +  EEL+Q  +  E   QA          +A  A  AE  R+
Sbjct: 1403 EEVVRREEAAVDAQQQKRSIQEELQQLRQSSEAEIQA----------KARQAEAAERSRL 1452

Query: 166  EGEEE--------DKEETQRDGAE-------SKERDGEGRPAKSQEEGKRL--YGRDEFE 208
              EEE        +  E QR GAE       ++  + E +  ++QEE +RL    +DE +
Sbjct: 1453 RIEEEIRVVRLQLEATERQRGGAEGELQALRARAEEAEAQKRQAQEEAERLRRQVQDESQ 1512

Query: 209  DLEWSE---------EVQKLQEQQLRSDLLDQYRSLLVERNRSQRYNLYLQHKIFEALRR 259
                +E         E +  +E+Q     L++ R    E  R  R          E  R 
Sbjct: 1513 RKRQAEVELASRVKAEAEAAREKQRALQALEELRLQAEEAERRLRQ--------AEVERA 1564

Query: 260  KKGLEAAEVADRGAEAEAPEKEQAYLRHLGMLEELKKQQADDLQWYHQELGQLKRQCQEK 319
            ++   A E A R AEAE   K  ++      LE         LQ  H  + QL+ + + +
Sbjct: 1565 RQVQVALETAQRSAEAELQSKRASFAEKTAQLER-------SLQEEHVAVAQLREEAERR 1617

Query: 320  L-TRVEKEWRRFQALKK----QVVMQAMGSCRMRGGRQAALREVEQIQALEDKKEKEMSA 374
               + E E  R +A ++    Q+        R++    A  + + Q +A + K+E E  A
Sbjct: 1618 AQQQAEAERAREEAERELERWQLKANEALRLRLQAEEVAQQKSLAQAEAEKQKEEAEREA 1677

Query: 375  VRLENIQLKQSLVHFETRMRTQEDLTQGLLLIDFEQLKIENQTFNEKIEERNEELLKLRS 434
             R    +        E  +R +E   Q L     +Q ++   T  +++    +EL++LR+
Sbjct: 1678 RRRGKAE--------EQAVRQRELAEQEL----EKQRQLAEGTAQQRL-AAEQELIRLRA 1724

Query: 435  KVTNSVQVITHVKEKLHFMDMENACKKTQLAEIEAQAALGRD----ILTKTKQAREGLRT 490
            +     Q    ++E+L  +  E A    +  E+EA+ A  R     +L    +A E  R+
Sbjct: 1725 ETEQGEQQRQLLEEELARLQREAAAATQKRQELEAELAKVRAEMEVLLASKARAEEESRS 1784

Query: 491  DNIRLNQKCGLLGKDSLLRDLEEKVDKTELL 521
             + +  Q+  L  +    R+L E+  +   L
Sbjct: 1785 TSEKSKQR--LEAEAGRFRELAEEAARLRAL 1813



 Score = 62.8 bits (151), Expect = 8e-10
 Identities = 99/447 (22%), Positives = 172/447 (38%), Gaps = 70/447 (15%)

Query: 119  ELEA----EAGAEELEQAAEGKEVRFQASLPLTRIDEEEAAAAPEAETERVEGEEEDKEE 174
            ELEA    +  AEE  +  E +E R Q SL      EEEAA   +A  E VE  +   EE
Sbjct: 1970 ELEAARQRQLAAEEERRRREAEE-RVQKSLAA----EEEAARQRKAALEEVERLKAKVEE 2024

Query: 175  TQRDGAESKERDGEGRPAKSQEEGKRLYGRDEFEDLEWSEEVQKLQEQ-QLRSDLLDQYR 233
             +R    +++          +   KRL   ++       ++ Q+LQ+  Q    +LDQ R
Sbjct: 2025 ARRLRERAEQESARQLQLAQEAAQKRLQAEEKAHAFAVQQKEQELQQTLQQEQSVLDQLR 2084

Query: 234  SLLVERNRSQRYNLYLQHKIFEALRRKKGLEAAEVADRGAEAEAPEKEQAYLRHLGMLEE 293
                                 EA   ++  E AE A   AE EA +  +           
Sbjct: 2085 G--------------------EAEAARRAAEEAEEARVQAEREAAQSRR----------- 2113

Query: 294  LKKQQADDLQWYHQELGQLKRQCQEKLTRVEKEWRRFQALKKQVVMQAMGSCRMRGGRQA 353
             + ++A+ L+   +E  Q + Q Q    ++ KE  +  A + Q               QA
Sbjct: 2114 -QVEEAERLKQSAEEQAQARAQAQAAAEKLRKEAEQEAARRAQ-------------AEQA 2159

Query: 354  ALREVEQIQALEDKKEKEMSAVRLENIQLKQSLVHFETRMRTQEDLTQGLLLIDFEQLK- 412
            ALR+ +   A  +K +K       +  Q++Q L     ++  + D  + LL  + ++LK 
Sbjct: 2160 ALRQKQAADAEMEKHKKFAEQTLRQKAQVEQELTTLRLQLE-ETDHQKNLLDEELQRLKA 2218

Query: 413  -----------IENQTFNEKIEERNEELLKLRSKVTNSVQVITHVKEKLHFMDMENACKK 461
                       +E + F+ +++      LK R +  N   ++        F+  E A K 
Sbjct: 2219 EATEAARQRSQVEEELFSVRVQMEELSKLKARIEAENRALILRDKDNTQRFL-QEEAEKM 2277

Query: 462  TQLAEIEAQAALGRDILTKTKQAREGLRTDNIRLNQKCGLLGKDSLLRDLEEKVDKTELL 521
             Q+AE  A+ ++      + +Q  E        L +K  L  K   +++      + ELL
Sbjct: 2278 KQVAEEAARLSVAAQEAARLRQLAEEDLAQQRALAEKM-LKEKMQAVQEATRLKAEAELL 2336

Query: 522  HRRLESLKRHHASLTLSCRGVRQKIRE 548
             ++ E  +     L      + Q++ E
Sbjct: 2337 QQQKELAQEQARRLQEDKEQMAQQLAE 2363



 Score = 62.8 bits (151), Expect = 8e-10
 Identities = 114/528 (21%), Positives = 218/528 (41%), Gaps = 53/528 (10%)

Query: 43   LESEPEEEEEEQAASQGGTAADEQAEAPKGLTAAEAAGEEGPGEPG----RPAEPQPEPE 98
            L+ E    ++ +  ++    A E+AE  +     EAA      E      + AE Q +  
Sbjct: 2073 LQQEQSVLDQLRGEAEAARRAAEEAEEARVQAEREAAQSRRQVEEAERLKQSAEEQAQAR 2132

Query: 99   EPAEVGAEEPAQPEPGAGPEELEAEAGAEELEQAAEGKEVRFQASLPLTRIDEEEAAAAP 158
              A+  AE+  +          +AE  A   +QAA+ +  + +     T    ++A    
Sbjct: 2133 AQAQAAAEKLRKEAEQEAARRAQAEQAALRQKQAADAEMEKHKKFAEQTL--RQKAQVEQ 2190

Query: 159  EAETERVEGEEEDKEETQRDGAESKERDGEGRPAKSQEEGKRLYGRDEFEDLEWSEEVQK 218
            E  T R++ EE D ++   D  E +    E   A  Q        R + E+  +S  VQ 
Sbjct: 2191 ELTTLRLQLEETDHQKNLLD-EELQRLKAEATEAARQ--------RSQVEEELFSVRVQM 2241

Query: 219  LQEQQLRSDLLDQYRSLLV-ERNRSQRYNLYLQHKIFEALRRKKGLEAAEVADRGAEAEA 277
             +  +L++ +  + R+L++ +++ +QR   +LQ    EA + K      +VA+  A    
Sbjct: 2242 EELSKLKARIEAENRALILRDKDNTQR---FLQE---EAEKMK------QVAEEAARLSV 2289

Query: 278  PEKEQAYLRHLGMLEELKKQQA------DDLQWYHQELGQLKRQC---QEKLTRVEKEWR 328
              +E A LR L   E+L +Q+A       +     QE  +LK +    Q++    +++ R
Sbjct: 2290 AAQEAARLRQLAE-EDLAQQRALAEKMLKEKMQAVQEATRLKAEAELLQQQKELAQEQAR 2348

Query: 329  RFQALKKQVVMQAMGSCRMRGGRQAALREVEQIQALEDKKEKEMSAVRLENIQLKQSLVH 388
            R Q  K+Q+  Q     +   G Q  L E E+ + LE   E E   +R+  +   Q+   
Sbjct: 2349 RLQEDKEQMAQQLAEETQ---GFQRTL-EAERQRQLEMSAEAERLKLRVAEMSRAQARAE 2404

Query: 389  FETRMRTQEDLTQGLLLIDFEQLKIENQTFNEKIEERNEELLKLRSKVTNSVQVITHVKE 448
             + +   ++    G  L   E    E  T  + +E + ++      ++  ++  +   KE
Sbjct: 2405 EDAQRFRKQAEEIGEKLHRTELATQEKVTLVQTLEIQRQQSDHDAERLREAIAELEREKE 2464

Query: 449  KLHFMDMENACKKTQLAEIEAQAALGRDILTKTKQAREGLRTDNIRLNQKCGLL--GKDS 506
            KL     +   K  QL   E Q      +L +T+  ++   ++   L Q+   +   K  
Sbjct: 2465 KL-----QQEAKLLQLKSEEMQTVQQEQLLQETQALQQSFLSEKDSLLQRERFIEQEKAK 2519

Query: 507  LLRDLEEKVDKTELL----HRRLESLKRHHASLTLSCRGVRQKIREAK 550
            L +  +++V K + L     R+ + +++    L  S    R++  EA+
Sbjct: 2520 LEQLFQDEVAKAQQLREEQQRQQQQMEQERQRLVASMEEARRRQHEAE 2567



 Score = 57.8 bits (138), Expect = 3e-08
 Identities = 120/542 (22%), Positives = 227/542 (41%), Gaps = 76/542 (14%)

Query: 43   LESEPEEEEEEQAASQGGTAADEQAEAPKGLTAAEAAGEEGPGEPG-RPAEPQPEPEEPA 101
            L+ EP  E  ++ A Q    A+ +    KG+    A  E+    P   PA P    E   
Sbjct: 1015 LDKEPARECAQRIAEQQKAQAEVEGLG-KGVARLSAEAEKVLALPEPSPAAPTLRSELEL 1073

Query: 102  EVGAEEPAQPEPGAGPEELEAEA-------GAEELEQAAEGKEVRFQASLPLTRIDEEEA 154
             +G  E  +       E+L+  +       GAEE+ +A E ++++   ++P T  + E  
Sbjct: 1074 TLGKLEQVRSLSAIYLEKLKTISLVIRGTQGAEEVLRAHE-EQLKEAQAVPATLPELE-- 1130

Query: 155  AAAPEAETERVEGEEEDKEETQRDGAESKERDGEGRPAKSQEEGKRLYGRDEFEDLE--- 211
              A +A  +++  + E ++ T  D    + R        +QE G+RL  R    D+E   
Sbjct: 1131 --ATKASLKKLRAQAEAQQPTF-DALRDELRG-------AQEVGERLQQRHGERDVEVER 1180

Query: 212  WSEEVQKLQEQ--------QLRSDLLDQY-RSLLVERNRSQRYNLYLQHKIFEALRRKKG 262
            W E V +L E+         +R   L+Q  R L   R  +     +LQ    +A RR++ 
Sbjct: 1181 WRERVAQLLERWQAVLAQTDVRQRELEQLGRQLRYYRESADPLGAWLQ----DARRRQEQ 1236

Query: 263  LEAAEVADRGAEAEAPEKEQAYL----RHLGMLEELK---KQQADDLQWYHQELGQLKRQ 315
            ++A  +AD  A  E   +EQA L    RH   +EE +   KQ  + ++ Y  +L   K Q
Sbjct: 1237 IQAMPLADSQAVREQLRQEQALLEEIERHGEKVEECQRFAKQYINAIKDYELQLVTYKAQ 1296

Query: 316  CQEKLTRVEKEWRRFQALKKQVVMQAMGSCRMRGGRQAAL--REVEQIQALEDKKEKEMS 373
             +   +  +K   + Q+  + V+ + +   R        L  + ++ I     + E+E  
Sbjct: 1297 LEPVASPAKKP--KVQSGSESVIQEYV-DLRTHYSELTTLTSQYIKFISETLRRMEEEER 1353

Query: 374  AVRLENIQLKQSLVHFETRMRTQEDLTQGLLLIDFEQLKIENQTFNEKIEER-NEELLKL 432
                +  + ++ L   E  +  Q  L +        Q K + +   +++++R  EE+++ 
Sbjct: 1354 LAEQQRAEERERLAEVEAALEKQRQLAEA-----HAQAKAQAEREAKELQQRMQEEVVRR 1408

Query: 433  RSKVTNSVQVITHVKEKLHFMDMENACKKTQLAEIEAQAALGRDILTKTKQAREGLRTDN 492
                 ++ Q    ++E+L  +      +++  AEI+A+A           +  E +R   
Sbjct: 1409 EEAAVDAQQQKRSIQEELQQL------RQSSEAEIQAKARQAEAAERSRLRIEEEIRVVR 1462

Query: 493  IRL----NQKCGLLGKDSLLRDLEEKV--------DKTELLHRRL--ESLKRHHASLTLS 538
            ++L     Q+ G  G+   LR   E+         ++ E L R++  ES ++  A + L+
Sbjct: 1463 LQLEATERQRGGAEGELQALRARAEEAEAQKRQAQEEAERLRRQVQDESQRKRQAEVELA 1522

Query: 539  CR 540
             R
Sbjct: 1523 SR 1524



 Score = 45.8 bits (107), Expect = 1e-04
 Identities = 86/441 (19%), Positives = 169/441 (38%), Gaps = 32/441 (7%)

Query: 42   ELESEPEEEEEEQAASQGGTAADEQAEAPKGLTAAEAAGEEGPGEPGRPAEPQPEPEEPA 101
            + E+E ++EE E+ A + G A +EQA   + L   E   +    E G   +     +E  
Sbjct: 1663 QAEAEKQKEEAEREARRRGKA-EEQAVRQRELAEQELEKQRQLAE-GTAQQRLAAEQELI 1720

Query: 102  EVGAE-EPAQPEPGAGPEEL---EAEAGA-----EELEQAAEGKEVRFQASLPLTRIDEE 152
             + AE E  + +     EEL   + EA A     +ELE          +  L      EE
Sbjct: 1721 RLRAETEQGEQQRQLLEEELARLQREAAAATQKRQELEAELAKVRAEMEVLLASKARAEE 1780

Query: 153  EAAAAPEAETERVEGEEEDKEETQRDGAESKERDGEGRPAKSQEEGKRLYGRDEFEDLEW 212
            E+ +  E   +R+E E     E   + A         R     EE KR          + 
Sbjct: 1781 ESRSTSEKSKQRLEAEAGRFRELAEEAA---------RLRALAEEAKR--------QRQL 1823

Query: 213  SEEVQKLQEQQLRSDLLDQYRSLLVERNRSQRYNLYLQHKIFEALRRKKGLEAAEVADRG 272
            +EE    Q  +    L ++  ++           + L+ K  E  R ++  E      R 
Sbjct: 1824 AEEDAARQRAEAERVLAEKLAAIGEATRLKTEAEIALKEKEAENERLRRLAEDEAFQRRR 1883

Query: 273  AEAEAPEKEQAYLRHLGMLEELKKQQADDLQWYHQELGQLKRQCQEKLTRVEKEWRRFQA 332
             E +A + +      L  L +    + +  +   ++  + +RQ +E++  ++  + +  A
Sbjct: 1884 LEEQAAQHKADIEERLAQLRKASDSELERQKGLVEDTLRQRRQVEEEILALKASFEKAAA 1943

Query: 333  LKKQVVMQAMGSCRMRGGRQAALREVEQIQALEDKKEKEMSAVRLENIQLKQSLVHFETR 392
             K ++ ++ +G  R+R   +  LR  EQ + LE  ++++++A      +  +  V     
Sbjct: 1944 GKAELELE-LG--RIRSNAEDTLRSKEQAE-LEAARQRQLAAEEERRRREAEERVQKSLA 1999

Query: 393  MRTQEDLTQGLLLIDFEQLKIENQTFNEKIEERNEELLKLRSKVTNSVQVITHVKEKLHF 452
               +    +   L + E+LK + +      E   +E  +       + Q     +EK H 
Sbjct: 2000 AEEEAARQRKAALEEVERLKAKVEEARRLRERAEQESARQLQLAQEAAQKRLQAEEKAHA 2059

Query: 453  MDMENACKKTQLAEIEAQAAL 473
              ++   ++ Q    + Q+ L
Sbjct: 2060 FAVQQKEQELQQTLQQEQSVL 2080



 Score = 32.3 bits (72), Expect = 1.2
 Identities = 27/102 (26%), Positives = 54/102 (52%), Gaps = 9/102 (8%)

Query: 141  QASLPLTRIDEEEAAAAPEAETERVEGEEEDKEETQR-----DGAESKERDGEGRPAKSQ 195
            Q    L ++ ++E A A +   E+   +++ ++E QR     + A  ++ + E    + Q
Sbjct: 2515 QEKAKLEQLFQDEVAKAQQLREEQQRQQQQMEQERQRLVASMEEARRRQHEAEEGVRRKQ 2574

Query: 196  EEGKRLYGRDEFEDLEWSEEVQKLQEQ-QLRSDLLDQYRSLL 236
            EE ++L  +   ++   +EE Q+L+EQ QL   L +Q+R+ L
Sbjct: 2575 EELQQLEQQRRQQEELLAEENQRLREQLQL---LEEQHRAAL 2613


>gi|41322919 plectin 1 isoform 8 [Homo sapiens]
          Length = 4547

 Score = 75.1 bits (183), Expect = 2e-13
 Identities = 121/511 (23%), Positives = 206/511 (40%), Gaps = 85/511 (16%)

Query: 50   EEEEQAASQGGTAADEQAEAPKGLTAAEAAGEE----GPGEPGRPAEPQPEPEEPAEVGA 105
            EEEE+ A Q      ++AE  + L   EAA E+            A+ + E +E  +   
Sbjct: 1345 EEEERLAEQ------QRAEERERLAEVEAALEKQRQLAEAHAQAKAQAEREAKELQQRMQ 1398

Query: 106  EEPAQPEPGAGPEELEAEAGAEELEQAAEGKEVRFQASLPLTRIDEEEAAAAPEAETERV 165
            EE  + E  A   + +  +  EEL+Q  +  E   QA          +A  A  AE  R+
Sbjct: 1399 EEVVRREEAAVDAQQQKRSIQEELQQLRQSSEAEIQA----------KARQAEAAERSRL 1448

Query: 166  EGEEE--------DKEETQRDGAE-------SKERDGEGRPAKSQEEGKRL--YGRDEFE 208
              EEE        +  E QR GAE       ++  + E +  ++QEE +RL    +DE +
Sbjct: 1449 RIEEEIRVVRLQLEATERQRGGAEGELQALRARAEEAEAQKRQAQEEAERLRRQVQDESQ 1508

Query: 209  DLEWSE---------EVQKLQEQQLRSDLLDQYRSLLVERNRSQRYNLYLQHKIFEALRR 259
                +E         E +  +E+Q     L++ R    E  R  R          E  R 
Sbjct: 1509 RKRQAEVELASRVKAEAEAAREKQRALQALEELRLQAEEAERRLRQ--------AEVERA 1560

Query: 260  KKGLEAAEVADRGAEAEAPEKEQAYLRHLGMLEELKKQQADDLQWYHQELGQLKRQCQEK 319
            ++   A E A R AEAE   K  ++      LE         LQ  H  + QL+ + + +
Sbjct: 1561 RQVQVALETAQRSAEAELQSKRASFAEKTAQLER-------SLQEEHVAVAQLREEAERR 1613

Query: 320  L-TRVEKEWRRFQALKK----QVVMQAMGSCRMRGGRQAALREVEQIQALEDKKEKEMSA 374
               + E E  R +A ++    Q+        R++    A  + + Q +A + K+E E  A
Sbjct: 1614 AQQQAEAERAREEAERELERWQLKANEALRLRLQAEEVAQQKSLAQAEAEKQKEEAEREA 1673

Query: 375  VRLENIQLKQSLVHFETRMRTQEDLTQGLLLIDFEQLKIENQTFNEKIEERNEELLKLRS 434
             R    +        E  +R +E   Q L     +Q ++   T  +++    +EL++LR+
Sbjct: 1674 RRRGKAE--------EQAVRQRELAEQEL----EKQRQLAEGTAQQRL-AAEQELIRLRA 1720

Query: 435  KVTNSVQVITHVKEKLHFMDMENACKKTQLAEIEAQAALGRD----ILTKTKQAREGLRT 490
            +     Q    ++E+L  +  E A    +  E+EA+ A  R     +L    +A E  R+
Sbjct: 1721 ETEQGEQQRQLLEEELARLQREAAAATQKRQELEAELAKVRAEMEVLLASKARAEEESRS 1780

Query: 491  DNIRLNQKCGLLGKDSLLRDLEEKVDKTELL 521
             + +  Q+  L  +    R+L E+  +   L
Sbjct: 1781 TSEKSKQR--LEAEAGRFRELAEEAARLRAL 1809



 Score = 62.8 bits (151), Expect = 8e-10
 Identities = 99/447 (22%), Positives = 172/447 (38%), Gaps = 70/447 (15%)

Query: 119  ELEA----EAGAEELEQAAEGKEVRFQASLPLTRIDEEEAAAAPEAETERVEGEEEDKEE 174
            ELEA    +  AEE  +  E +E R Q SL      EEEAA   +A  E VE  +   EE
Sbjct: 1966 ELEAARQRQLAAEEERRRREAEE-RVQKSLAA----EEEAARQRKAALEEVERLKAKVEE 2020

Query: 175  TQRDGAESKERDGEGRPAKSQEEGKRLYGRDEFEDLEWSEEVQKLQEQ-QLRSDLLDQYR 233
             +R    +++          +   KRL   ++       ++ Q+LQ+  Q    +LDQ R
Sbjct: 2021 ARRLRERAEQESARQLQLAQEAAQKRLQAEEKAHAFAVQQKEQELQQTLQQEQSVLDQLR 2080

Query: 234  SLLVERNRSQRYNLYLQHKIFEALRRKKGLEAAEVADRGAEAEAPEKEQAYLRHLGMLEE 293
                                 EA   ++  E AE A   AE EA +  +           
Sbjct: 2081 G--------------------EAEAARRAAEEAEEARVQAEREAAQSRR----------- 2109

Query: 294  LKKQQADDLQWYHQELGQLKRQCQEKLTRVEKEWRRFQALKKQVVMQAMGSCRMRGGRQA 353
             + ++A+ L+   +E  Q + Q Q    ++ KE  +  A + Q               QA
Sbjct: 2110 -QVEEAERLKQSAEEQAQARAQAQAAAEKLRKEAEQEAARRAQ-------------AEQA 2155

Query: 354  ALREVEQIQALEDKKEKEMSAVRLENIQLKQSLVHFETRMRTQEDLTQGLLLIDFEQLK- 412
            ALR+ +   A  +K +K       +  Q++Q L     ++  + D  + LL  + ++LK 
Sbjct: 2156 ALRQKQAADAEMEKHKKFAEQTLRQKAQVEQELTTLRLQLE-ETDHQKNLLDEELQRLKA 2214

Query: 413  -----------IENQTFNEKIEERNEELLKLRSKVTNSVQVITHVKEKLHFMDMENACKK 461
                       +E + F+ +++      LK R +  N   ++        F+  E A K 
Sbjct: 2215 EATEAARQRSQVEEELFSVRVQMEELSKLKARIEAENRALILRDKDNTQRFL-QEEAEKM 2273

Query: 462  TQLAEIEAQAALGRDILTKTKQAREGLRTDNIRLNQKCGLLGKDSLLRDLEEKVDKTELL 521
             Q+AE  A+ ++      + +Q  E        L +K  L  K   +++      + ELL
Sbjct: 2274 KQVAEEAARLSVAAQEAARLRQLAEEDLAQQRALAEKM-LKEKMQAVQEATRLKAEAELL 2332

Query: 522  HRRLESLKRHHASLTLSCRGVRQKIRE 548
             ++ E  +     L      + Q++ E
Sbjct: 2333 QQQKELAQEQARRLQEDKEQMAQQLAE 2359



 Score = 62.8 bits (151), Expect = 8e-10
 Identities = 114/528 (21%), Positives = 218/528 (41%), Gaps = 53/528 (10%)

Query: 43   LESEPEEEEEEQAASQGGTAADEQAEAPKGLTAAEAAGEEGPGEPG----RPAEPQPEPE 98
            L+ E    ++ +  ++    A E+AE  +     EAA      E      + AE Q +  
Sbjct: 2069 LQQEQSVLDQLRGEAEAARRAAEEAEEARVQAEREAAQSRRQVEEAERLKQSAEEQAQAR 2128

Query: 99   EPAEVGAEEPAQPEPGAGPEELEAEAGAEELEQAAEGKEVRFQASLPLTRIDEEEAAAAP 158
              A+  AE+  +          +AE  A   +QAA+ +  + +     T    ++A    
Sbjct: 2129 AQAQAAAEKLRKEAEQEAARRAQAEQAALRQKQAADAEMEKHKKFAEQTL--RQKAQVEQ 2186

Query: 159  EAETERVEGEEEDKEETQRDGAESKERDGEGRPAKSQEEGKRLYGRDEFEDLEWSEEVQK 218
            E  T R++ EE D ++   D  E +    E   A  Q        R + E+  +S  VQ 
Sbjct: 2187 ELTTLRLQLEETDHQKNLLD-EELQRLKAEATEAARQ--------RSQVEEELFSVRVQM 2237

Query: 219  LQEQQLRSDLLDQYRSLLV-ERNRSQRYNLYLQHKIFEALRRKKGLEAAEVADRGAEAEA 277
             +  +L++ +  + R+L++ +++ +QR   +LQ    EA + K      +VA+  A    
Sbjct: 2238 EELSKLKARIEAENRALILRDKDNTQR---FLQE---EAEKMK------QVAEEAARLSV 2285

Query: 278  PEKEQAYLRHLGMLEELKKQQA------DDLQWYHQELGQLKRQC---QEKLTRVEKEWR 328
              +E A LR L   E+L +Q+A       +     QE  +LK +    Q++    +++ R
Sbjct: 2286 AAQEAARLRQLAE-EDLAQQRALAEKMLKEKMQAVQEATRLKAEAELLQQQKELAQEQAR 2344

Query: 329  RFQALKKQVVMQAMGSCRMRGGRQAALREVEQIQALEDKKEKEMSAVRLENIQLKQSLVH 388
            R Q  K+Q+  Q     +   G Q  L E E+ + LE   E E   +R+  +   Q+   
Sbjct: 2345 RLQEDKEQMAQQLAEETQ---GFQRTL-EAERQRQLEMSAEAERLKLRVAEMSRAQARAE 2400

Query: 389  FETRMRTQEDLTQGLLLIDFEQLKIENQTFNEKIEERNEELLKLRSKVTNSVQVITHVKE 448
             + +   ++    G  L   E    E  T  + +E + ++      ++  ++  +   KE
Sbjct: 2401 EDAQRFRKQAEEIGEKLHRTELATQEKVTLVQTLEIQRQQSDHDAERLREAIAELEREKE 2460

Query: 449  KLHFMDMENACKKTQLAEIEAQAALGRDILTKTKQAREGLRTDNIRLNQKCGLL--GKDS 506
            KL     +   K  QL   E Q      +L +T+  ++   ++   L Q+   +   K  
Sbjct: 2461 KL-----QQEAKLLQLKSEEMQTVQQEQLLQETQALQQSFLSEKDSLLQRERFIEQEKAK 2515

Query: 507  LLRDLEEKVDKTELL----HRRLESLKRHHASLTLSCRGVRQKIREAK 550
            L +  +++V K + L     R+ + +++    L  S    R++  EA+
Sbjct: 2516 LEQLFQDEVAKAQQLREEQQRQQQQMEQERQRLVASMEEARRRQHEAE 2563



 Score = 57.8 bits (138), Expect = 3e-08
 Identities = 120/542 (22%), Positives = 227/542 (41%), Gaps = 76/542 (14%)

Query: 43   LESEPEEEEEEQAASQGGTAADEQAEAPKGLTAAEAAGEEGPGEPG-RPAEPQPEPEEPA 101
            L+ EP  E  ++ A Q    A+ +    KG+    A  E+    P   PA P    E   
Sbjct: 1011 LDKEPARECAQRIAEQQKAQAEVEGLG-KGVARLSAEAEKVLALPEPSPAAPTLRSELEL 1069

Query: 102  EVGAEEPAQPEPGAGPEELEAEA-------GAEELEQAAEGKEVRFQASLPLTRIDEEEA 154
             +G  E  +       E+L+  +       GAEE+ +A E ++++   ++P T  + E  
Sbjct: 1070 TLGKLEQVRSLSAIYLEKLKTISLVIRGTQGAEEVLRAHE-EQLKEAQAVPATLPELE-- 1126

Query: 155  AAAPEAETERVEGEEEDKEETQRDGAESKERDGEGRPAKSQEEGKRLYGRDEFEDLE--- 211
              A +A  +++  + E ++ T  D    + R        +QE G+RL  R    D+E   
Sbjct: 1127 --ATKASLKKLRAQAEAQQPTF-DALRDELRG-------AQEVGERLQQRHGERDVEVER 1176

Query: 212  WSEEVQKLQEQ--------QLRSDLLDQY-RSLLVERNRSQRYNLYLQHKIFEALRRKKG 262
            W E V +L E+         +R   L+Q  R L   R  +     +LQ    +A RR++ 
Sbjct: 1177 WRERVAQLLERWQAVLAQTDVRQRELEQLGRQLRYYRESADPLGAWLQ----DARRRQEQ 1232

Query: 263  LEAAEVADRGAEAEAPEKEQAYL----RHLGMLEELK---KQQADDLQWYHQELGQLKRQ 315
            ++A  +AD  A  E   +EQA L    RH   +EE +   KQ  + ++ Y  +L   K Q
Sbjct: 1233 IQAMPLADSQAVREQLRQEQALLEEIERHGEKVEECQRFAKQYINAIKDYELQLVTYKAQ 1292

Query: 316  CQEKLTRVEKEWRRFQALKKQVVMQAMGSCRMRGGRQAAL--REVEQIQALEDKKEKEMS 373
             +   +  +K   + Q+  + V+ + +   R        L  + ++ I     + E+E  
Sbjct: 1293 LEPVASPAKKP--KVQSGSESVIQEYV-DLRTHYSELTTLTSQYIKFISETLRRMEEEER 1349

Query: 374  AVRLENIQLKQSLVHFETRMRTQEDLTQGLLLIDFEQLKIENQTFNEKIEER-NEELLKL 432
                +  + ++ L   E  +  Q  L +        Q K + +   +++++R  EE+++ 
Sbjct: 1350 LAEQQRAEERERLAEVEAALEKQRQLAEA-----HAQAKAQAEREAKELQQRMQEEVVRR 1404

Query: 433  RSKVTNSVQVITHVKEKLHFMDMENACKKTQLAEIEAQAALGRDILTKTKQAREGLRTDN 492
                 ++ Q    ++E+L  +      +++  AEI+A+A           +  E +R   
Sbjct: 1405 EEAAVDAQQQKRSIQEELQQL------RQSSEAEIQAKARQAEAAERSRLRIEEEIRVVR 1458

Query: 493  IRL----NQKCGLLGKDSLLRDLEEKV--------DKTELLHRRL--ESLKRHHASLTLS 538
            ++L     Q+ G  G+   LR   E+         ++ E L R++  ES ++  A + L+
Sbjct: 1459 LQLEATERQRGGAEGELQALRARAEEAEAQKRQAQEEAERLRRQVQDESQRKRQAEVELA 1518

Query: 539  CR 540
             R
Sbjct: 1519 SR 1520



 Score = 45.8 bits (107), Expect = 1e-04
 Identities = 86/441 (19%), Positives = 169/441 (38%), Gaps = 32/441 (7%)

Query: 42   ELESEPEEEEEEQAASQGGTAADEQAEAPKGLTAAEAAGEEGPGEPGRPAEPQPEPEEPA 101
            + E+E ++EE E+ A + G A +EQA   + L   E   +    E G   +     +E  
Sbjct: 1659 QAEAEKQKEEAEREARRRGKA-EEQAVRQRELAEQELEKQRQLAE-GTAQQRLAAEQELI 1716

Query: 102  EVGAE-EPAQPEPGAGPEEL---EAEAGA-----EELEQAAEGKEVRFQASLPLTRIDEE 152
             + AE E  + +     EEL   + EA A     +ELE          +  L      EE
Sbjct: 1717 RLRAETEQGEQQRQLLEEELARLQREAAAATQKRQELEAELAKVRAEMEVLLASKARAEE 1776

Query: 153  EAAAAPEAETERVEGEEEDKEETQRDGAESKERDGEGRPAKSQEEGKRLYGRDEFEDLEW 212
            E+ +  E   +R+E E     E   + A         R     EE KR          + 
Sbjct: 1777 ESRSTSEKSKQRLEAEAGRFRELAEEAA---------RLRALAEEAKR--------QRQL 1819

Query: 213  SEEVQKLQEQQLRSDLLDQYRSLLVERNRSQRYNLYLQHKIFEALRRKKGLEAAEVADRG 272
            +EE    Q  +    L ++  ++           + L+ K  E  R ++  E      R 
Sbjct: 1820 AEEDAARQRAEAERVLAEKLAAIGEATRLKTEAEIALKEKEAENERLRRLAEDEAFQRRR 1879

Query: 273  AEAEAPEKEQAYLRHLGMLEELKKQQADDLQWYHQELGQLKRQCQEKLTRVEKEWRRFQA 332
             E +A + +      L  L +    + +  +   ++  + +RQ +E++  ++  + +  A
Sbjct: 1880 LEEQAAQHKADIEERLAQLRKASDSELERQKGLVEDTLRQRRQVEEEILALKASFEKAAA 1939

Query: 333  LKKQVVMQAMGSCRMRGGRQAALREVEQIQALEDKKEKEMSAVRLENIQLKQSLVHFETR 392
             K ++ ++ +G  R+R   +  LR  EQ + LE  ++++++A      +  +  V     
Sbjct: 1940 GKAELELE-LG--RIRSNAEDTLRSKEQAE-LEAARQRQLAAEEERRRREAEERVQKSLA 1995

Query: 393  MRTQEDLTQGLLLIDFEQLKIENQTFNEKIEERNEELLKLRSKVTNSVQVITHVKEKLHF 452
               +    +   L + E+LK + +      E   +E  +       + Q     +EK H 
Sbjct: 1996 AEEEAARQRKAALEEVERLKAKVEEARRLRERAEQESARQLQLAQEAAQKRLQAEEKAHA 2055

Query: 453  MDMENACKKTQLAEIEAQAAL 473
              ++   ++ Q    + Q+ L
Sbjct: 2056 FAVQQKEQELQQTLQQEQSVL 2076



 Score = 32.3 bits (72), Expect = 1.2
 Identities = 27/102 (26%), Positives = 54/102 (52%), Gaps = 9/102 (8%)

Query: 141  QASLPLTRIDEEEAAAAPEAETERVEGEEEDKEETQR-----DGAESKERDGEGRPAKSQ 195
            Q    L ++ ++E A A +   E+   +++ ++E QR     + A  ++ + E    + Q
Sbjct: 2511 QEKAKLEQLFQDEVAKAQQLREEQQRQQQQMEQERQRLVASMEEARRRQHEAEEGVRRKQ 2570

Query: 196  EEGKRLYGRDEFEDLEWSEEVQKLQEQ-QLRSDLLDQYRSLL 236
            EE ++L  +   ++   +EE Q+L+EQ QL   L +Q+R+ L
Sbjct: 2571 EELQQLEQQRRQQEELLAEENQRLREQLQL---LEEQHRAAL 2609


>gi|41322910 plectin 1 isoform 7 [Homo sapiens]
          Length = 4515

 Score = 75.1 bits (183), Expect = 2e-13
 Identities = 121/511 (23%), Positives = 206/511 (40%), Gaps = 85/511 (16%)

Query: 50   EEEEQAASQGGTAADEQAEAPKGLTAAEAAGEE----GPGEPGRPAEPQPEPEEPAEVGA 105
            EEEE+ A Q      ++AE  + L   EAA E+            A+ + E +E  +   
Sbjct: 1313 EEEERLAEQ------QRAEERERLAEVEAALEKQRQLAEAHAQAKAQAEREAKELQQRMQ 1366

Query: 106  EEPAQPEPGAGPEELEAEAGAEELEQAAEGKEVRFQASLPLTRIDEEEAAAAPEAETERV 165
            EE  + E  A   + +  +  EEL+Q  +  E   QA          +A  A  AE  R+
Sbjct: 1367 EEVVRREEAAVDAQQQKRSIQEELQQLRQSSEAEIQA----------KARQAEAAERSRL 1416

Query: 166  EGEEE--------DKEETQRDGAE-------SKERDGEGRPAKSQEEGKRL--YGRDEFE 208
              EEE        +  E QR GAE       ++  + E +  ++QEE +RL    +DE +
Sbjct: 1417 RIEEEIRVVRLQLEATERQRGGAEGELQALRARAEEAEAQKRQAQEEAERLRRQVQDESQ 1476

Query: 209  DLEWSE---------EVQKLQEQQLRSDLLDQYRSLLVERNRSQRYNLYLQHKIFEALRR 259
                +E         E +  +E+Q     L++ R    E  R  R          E  R 
Sbjct: 1477 RKRQAEVELASRVKAEAEAAREKQRALQALEELRLQAEEAERRLRQ--------AEVERA 1528

Query: 260  KKGLEAAEVADRGAEAEAPEKEQAYLRHLGMLEELKKQQADDLQWYHQELGQLKRQCQEK 319
            ++   A E A R AEAE   K  ++      LE         LQ  H  + QL+ + + +
Sbjct: 1529 RQVQVALETAQRSAEAELQSKRASFAEKTAQLER-------SLQEEHVAVAQLREEAERR 1581

Query: 320  L-TRVEKEWRRFQALKK----QVVMQAMGSCRMRGGRQAALREVEQIQALEDKKEKEMSA 374
               + E E  R +A ++    Q+        R++    A  + + Q +A + K+E E  A
Sbjct: 1582 AQQQAEAERAREEAERELERWQLKANEALRLRLQAEEVAQQKSLAQAEAEKQKEEAEREA 1641

Query: 375  VRLENIQLKQSLVHFETRMRTQEDLTQGLLLIDFEQLKIENQTFNEKIEERNEELLKLRS 434
             R    +        E  +R +E   Q L     +Q ++   T  +++    +EL++LR+
Sbjct: 1642 RRRGKAE--------EQAVRQRELAEQEL----EKQRQLAEGTAQQRL-AAEQELIRLRA 1688

Query: 435  KVTNSVQVITHVKEKLHFMDMENACKKTQLAEIEAQAALGRD----ILTKTKQAREGLRT 490
            +     Q    ++E+L  +  E A    +  E+EA+ A  R     +L    +A E  R+
Sbjct: 1689 ETEQGEQQRQLLEEELARLQREAAAATQKRQELEAELAKVRAEMEVLLASKARAEEESRS 1748

Query: 491  DNIRLNQKCGLLGKDSLLRDLEEKVDKTELL 521
             + +  Q+  L  +    R+L E+  +   L
Sbjct: 1749 TSEKSKQR--LEAEAGRFRELAEEAARLRAL 1777



 Score = 62.8 bits (151), Expect = 8e-10
 Identities = 99/447 (22%), Positives = 172/447 (38%), Gaps = 70/447 (15%)

Query: 119  ELEA----EAGAEELEQAAEGKEVRFQASLPLTRIDEEEAAAAPEAETERVEGEEEDKEE 174
            ELEA    +  AEE  +  E +E R Q SL      EEEAA   +A  E VE  +   EE
Sbjct: 1934 ELEAARQRQLAAEEERRRREAEE-RVQKSLAA----EEEAARQRKAALEEVERLKAKVEE 1988

Query: 175  TQRDGAESKERDGEGRPAKSQEEGKRLYGRDEFEDLEWSEEVQKLQEQ-QLRSDLLDQYR 233
             +R    +++          +   KRL   ++       ++ Q+LQ+  Q    +LDQ R
Sbjct: 1989 ARRLRERAEQESARQLQLAQEAAQKRLQAEEKAHAFAVQQKEQELQQTLQQEQSVLDQLR 2048

Query: 234  SLLVERNRSQRYNLYLQHKIFEALRRKKGLEAAEVADRGAEAEAPEKEQAYLRHLGMLEE 293
                                 EA   ++  E AE A   AE EA +  +           
Sbjct: 2049 G--------------------EAEAARRAAEEAEEARVQAEREAAQSRR----------- 2077

Query: 294  LKKQQADDLQWYHQELGQLKRQCQEKLTRVEKEWRRFQALKKQVVMQAMGSCRMRGGRQA 353
             + ++A+ L+   +E  Q + Q Q    ++ KE  +  A + Q               QA
Sbjct: 2078 -QVEEAERLKQSAEEQAQARAQAQAAAEKLRKEAEQEAARRAQ-------------AEQA 2123

Query: 354  ALREVEQIQALEDKKEKEMSAVRLENIQLKQSLVHFETRMRTQEDLTQGLLLIDFEQLK- 412
            ALR+ +   A  +K +K       +  Q++Q L     ++  + D  + LL  + ++LK 
Sbjct: 2124 ALRQKQAADAEMEKHKKFAEQTLRQKAQVEQELTTLRLQLE-ETDHQKNLLDEELQRLKA 2182

Query: 413  -----------IENQTFNEKIEERNEELLKLRSKVTNSVQVITHVKEKLHFMDMENACKK 461
                       +E + F+ +++      LK R +  N   ++        F+  E A K 
Sbjct: 2183 EATEAARQRSQVEEELFSVRVQMEELSKLKARIEAENRALILRDKDNTQRFL-QEEAEKM 2241

Query: 462  TQLAEIEAQAALGRDILTKTKQAREGLRTDNIRLNQKCGLLGKDSLLRDLEEKVDKTELL 521
             Q+AE  A+ ++      + +Q  E        L +K  L  K   +++      + ELL
Sbjct: 2242 KQVAEEAARLSVAAQEAARLRQLAEEDLAQQRALAEKM-LKEKMQAVQEATRLKAEAELL 2300

Query: 522  HRRLESLKRHHASLTLSCRGVRQKIRE 548
             ++ E  +     L      + Q++ E
Sbjct: 2301 QQQKELAQEQARRLQEDKEQMAQQLAE 2327



 Score = 62.8 bits (151), Expect = 8e-10
 Identities = 114/528 (21%), Positives = 218/528 (41%), Gaps = 53/528 (10%)

Query: 43   LESEPEEEEEEQAASQGGTAADEQAEAPKGLTAAEAAGEEGPGEPG----RPAEPQPEPE 98
            L+ E    ++ +  ++    A E+AE  +     EAA      E      + AE Q +  
Sbjct: 2037 LQQEQSVLDQLRGEAEAARRAAEEAEEARVQAEREAAQSRRQVEEAERLKQSAEEQAQAR 2096

Query: 99   EPAEVGAEEPAQPEPGAGPEELEAEAGAEELEQAAEGKEVRFQASLPLTRIDEEEAAAAP 158
              A+  AE+  +          +AE  A   +QAA+ +  + +     T    ++A    
Sbjct: 2097 AQAQAAAEKLRKEAEQEAARRAQAEQAALRQKQAADAEMEKHKKFAEQTL--RQKAQVEQ 2154

Query: 159  EAETERVEGEEEDKEETQRDGAESKERDGEGRPAKSQEEGKRLYGRDEFEDLEWSEEVQK 218
            E  T R++ EE D ++   D  E +    E   A  Q        R + E+  +S  VQ 
Sbjct: 2155 ELTTLRLQLEETDHQKNLLD-EELQRLKAEATEAARQ--------RSQVEEELFSVRVQM 2205

Query: 219  LQEQQLRSDLLDQYRSLLV-ERNRSQRYNLYLQHKIFEALRRKKGLEAAEVADRGAEAEA 277
             +  +L++ +  + R+L++ +++ +QR   +LQ    EA + K      +VA+  A    
Sbjct: 2206 EELSKLKARIEAENRALILRDKDNTQR---FLQE---EAEKMK------QVAEEAARLSV 2253

Query: 278  PEKEQAYLRHLGMLEELKKQQA------DDLQWYHQELGQLKRQC---QEKLTRVEKEWR 328
              +E A LR L   E+L +Q+A       +     QE  +LK +    Q++    +++ R
Sbjct: 2254 AAQEAARLRQLAE-EDLAQQRALAEKMLKEKMQAVQEATRLKAEAELLQQQKELAQEQAR 2312

Query: 329  RFQALKKQVVMQAMGSCRMRGGRQAALREVEQIQALEDKKEKEMSAVRLENIQLKQSLVH 388
            R Q  K+Q+  Q     +   G Q  L E E+ + LE   E E   +R+  +   Q+   
Sbjct: 2313 RLQEDKEQMAQQLAEETQ---GFQRTL-EAERQRQLEMSAEAERLKLRVAEMSRAQARAE 2368

Query: 389  FETRMRTQEDLTQGLLLIDFEQLKIENQTFNEKIEERNEELLKLRSKVTNSVQVITHVKE 448
             + +   ++    G  L   E    E  T  + +E + ++      ++  ++  +   KE
Sbjct: 2369 EDAQRFRKQAEEIGEKLHRTELATQEKVTLVQTLEIQRQQSDHDAERLREAIAELEREKE 2428

Query: 449  KLHFMDMENACKKTQLAEIEAQAALGRDILTKTKQAREGLRTDNIRLNQKCGLL--GKDS 506
            KL     +   K  QL   E Q      +L +T+  ++   ++   L Q+   +   K  
Sbjct: 2429 KL-----QQEAKLLQLKSEEMQTVQQEQLLQETQALQQSFLSEKDSLLQRERFIEQEKAK 2483

Query: 507  LLRDLEEKVDKTELL----HRRLESLKRHHASLTLSCRGVRQKIREAK 550
            L +  +++V K + L     R+ + +++    L  S    R++  EA+
Sbjct: 2484 LEQLFQDEVAKAQQLREEQQRQQQQMEQERQRLVASMEEARRRQHEAE 2531



 Score = 57.8 bits (138), Expect = 3e-08
 Identities = 120/542 (22%), Positives = 227/542 (41%), Gaps = 76/542 (14%)

Query: 43   LESEPEEEEEEQAASQGGTAADEQAEAPKGLTAAEAAGEEGPGEPG-RPAEPQPEPEEPA 101
            L+ EP  E  ++ A Q    A+ +    KG+    A  E+    P   PA P    E   
Sbjct: 979  LDKEPARECAQRIAEQQKAQAEVEGLG-KGVARLSAEAEKVLALPEPSPAAPTLRSELEL 1037

Query: 102  EVGAEEPAQPEPGAGPEELEAEA-------GAEELEQAAEGKEVRFQASLPLTRIDEEEA 154
             +G  E  +       E+L+  +       GAEE+ +A E ++++   ++P T  + E  
Sbjct: 1038 TLGKLEQVRSLSAIYLEKLKTISLVIRGTQGAEEVLRAHE-EQLKEAQAVPATLPELE-- 1094

Query: 155  AAAPEAETERVEGEEEDKEETQRDGAESKERDGEGRPAKSQEEGKRLYGRDEFEDLE--- 211
              A +A  +++  + E ++ T  D    + R        +QE G+RL  R    D+E   
Sbjct: 1095 --ATKASLKKLRAQAEAQQPTF-DALRDELRG-------AQEVGERLQQRHGERDVEVER 1144

Query: 212  WSEEVQKLQEQ--------QLRSDLLDQY-RSLLVERNRSQRYNLYLQHKIFEALRRKKG 262
            W E V +L E+         +R   L+Q  R L   R  +     +LQ    +A RR++ 
Sbjct: 1145 WRERVAQLLERWQAVLAQTDVRQRELEQLGRQLRYYRESADPLGAWLQ----DARRRQEQ 1200

Query: 263  LEAAEVADRGAEAEAPEKEQAYL----RHLGMLEELK---KQQADDLQWYHQELGQLKRQ 315
            ++A  +AD  A  E   +EQA L    RH   +EE +   KQ  + ++ Y  +L   K Q
Sbjct: 1201 IQAMPLADSQAVREQLRQEQALLEEIERHGEKVEECQRFAKQYINAIKDYELQLVTYKAQ 1260

Query: 316  CQEKLTRVEKEWRRFQALKKQVVMQAMGSCRMRGGRQAAL--REVEQIQALEDKKEKEMS 373
             +   +  +K   + Q+  + V+ + +   R        L  + ++ I     + E+E  
Sbjct: 1261 LEPVASPAKKP--KVQSGSESVIQEYV-DLRTHYSELTTLTSQYIKFISETLRRMEEEER 1317

Query: 374  AVRLENIQLKQSLVHFETRMRTQEDLTQGLLLIDFEQLKIENQTFNEKIEER-NEELLKL 432
                +  + ++ L   E  +  Q  L +        Q K + +   +++++R  EE+++ 
Sbjct: 1318 LAEQQRAEERERLAEVEAALEKQRQLAEA-----HAQAKAQAEREAKELQQRMQEEVVRR 1372

Query: 433  RSKVTNSVQVITHVKEKLHFMDMENACKKTQLAEIEAQAALGRDILTKTKQAREGLRTDN 492
                 ++ Q    ++E+L  +      +++  AEI+A+A           +  E +R   
Sbjct: 1373 EEAAVDAQQQKRSIQEELQQL------RQSSEAEIQAKARQAEAAERSRLRIEEEIRVVR 1426

Query: 493  IRL----NQKCGLLGKDSLLRDLEEKV--------DKTELLHRRL--ESLKRHHASLTLS 538
            ++L     Q+ G  G+   LR   E+         ++ E L R++  ES ++  A + L+
Sbjct: 1427 LQLEATERQRGGAEGELQALRARAEEAEAQKRQAQEEAERLRRQVQDESQRKRQAEVELA 1486

Query: 539  CR 540
             R
Sbjct: 1487 SR 1488



 Score = 45.8 bits (107), Expect = 1e-04
 Identities = 86/441 (19%), Positives = 169/441 (38%), Gaps = 32/441 (7%)

Query: 42   ELESEPEEEEEEQAASQGGTAADEQAEAPKGLTAAEAAGEEGPGEPGRPAEPQPEPEEPA 101
            + E+E ++EE E+ A + G A +EQA   + L   E   +    E G   +     +E  
Sbjct: 1627 QAEAEKQKEEAEREARRRGKA-EEQAVRQRELAEQELEKQRQLAE-GTAQQRLAAEQELI 1684

Query: 102  EVGAE-EPAQPEPGAGPEEL---EAEAGA-----EELEQAAEGKEVRFQASLPLTRIDEE 152
             + AE E  + +     EEL   + EA A     +ELE          +  L      EE
Sbjct: 1685 RLRAETEQGEQQRQLLEEELARLQREAAAATQKRQELEAELAKVRAEMEVLLASKARAEE 1744

Query: 153  EAAAAPEAETERVEGEEEDKEETQRDGAESKERDGEGRPAKSQEEGKRLYGRDEFEDLEW 212
            E+ +  E   +R+E E     E   + A         R     EE KR          + 
Sbjct: 1745 ESRSTSEKSKQRLEAEAGRFRELAEEAA---------RLRALAEEAKR--------QRQL 1787

Query: 213  SEEVQKLQEQQLRSDLLDQYRSLLVERNRSQRYNLYLQHKIFEALRRKKGLEAAEVADRG 272
            +EE    Q  +    L ++  ++           + L+ K  E  R ++  E      R 
Sbjct: 1788 AEEDAARQRAEAERVLAEKLAAIGEATRLKTEAEIALKEKEAENERLRRLAEDEAFQRRR 1847

Query: 273  AEAEAPEKEQAYLRHLGMLEELKKQQADDLQWYHQELGQLKRQCQEKLTRVEKEWRRFQA 332
             E +A + +      L  L +    + +  +   ++  + +RQ +E++  ++  + +  A
Sbjct: 1848 LEEQAAQHKADIEERLAQLRKASDSELERQKGLVEDTLRQRRQVEEEILALKASFEKAAA 1907

Query: 333  LKKQVVMQAMGSCRMRGGRQAALREVEQIQALEDKKEKEMSAVRLENIQLKQSLVHFETR 392
             K ++ ++ +G  R+R   +  LR  EQ + LE  ++++++A      +  +  V     
Sbjct: 1908 GKAELELE-LG--RIRSNAEDTLRSKEQAE-LEAARQRQLAAEEERRRREAEERVQKSLA 1963

Query: 393  MRTQEDLTQGLLLIDFEQLKIENQTFNEKIEERNEELLKLRSKVTNSVQVITHVKEKLHF 452
               +    +   L + E+LK + +      E   +E  +       + Q     +EK H 
Sbjct: 1964 AEEEAARQRKAALEEVERLKAKVEEARRLRERAEQESARQLQLAQEAAQKRLQAEEKAHA 2023

Query: 453  MDMENACKKTQLAEIEAQAAL 473
              ++   ++ Q    + Q+ L
Sbjct: 2024 FAVQQKEQELQQTLQQEQSVL 2044



 Score = 32.3 bits (72), Expect = 1.2
 Identities = 27/102 (26%), Positives = 54/102 (52%), Gaps = 9/102 (8%)

Query: 141  QASLPLTRIDEEEAAAAPEAETERVEGEEEDKEETQR-----DGAESKERDGEGRPAKSQ 195
            Q    L ++ ++E A A +   E+   +++ ++E QR     + A  ++ + E    + Q
Sbjct: 2479 QEKAKLEQLFQDEVAKAQQLREEQQRQQQQMEQERQRLVASMEEARRRQHEAEEGVRRKQ 2538

Query: 196  EEGKRLYGRDEFEDLEWSEEVQKLQEQ-QLRSDLLDQYRSLL 236
            EE ++L  +   ++   +EE Q+L+EQ QL   L +Q+R+ L
Sbjct: 2539 EELQQLEQQRRQQEELLAEENQRLREQLQL---LEEQHRAAL 2577


>gi|41322916 plectin 1 isoform 6 [Homo sapiens]
          Length = 4684

 Score = 75.1 bits (183), Expect = 2e-13
 Identities = 121/511 (23%), Positives = 206/511 (40%), Gaps = 85/511 (16%)

Query: 50   EEEEQAASQGGTAADEQAEAPKGLTAAEAAGEE----GPGEPGRPAEPQPEPEEPAEVGA 105
            EEEE+ A Q      ++AE  + L   EAA E+            A+ + E +E  +   
Sbjct: 1482 EEEERLAEQ------QRAEERERLAEVEAALEKQRQLAEAHAQAKAQAEREAKELQQRMQ 1535

Query: 106  EEPAQPEPGAGPEELEAEAGAEELEQAAEGKEVRFQASLPLTRIDEEEAAAAPEAETERV 165
            EE  + E  A   + +  +  EEL+Q  +  E   QA          +A  A  AE  R+
Sbjct: 1536 EEVVRREEAAVDAQQQKRSIQEELQQLRQSSEAEIQA----------KARQAEAAERSRL 1585

Query: 166  EGEEE--------DKEETQRDGAE-------SKERDGEGRPAKSQEEGKRL--YGRDEFE 208
              EEE        +  E QR GAE       ++  + E +  ++QEE +RL    +DE +
Sbjct: 1586 RIEEEIRVVRLQLEATERQRGGAEGELQALRARAEEAEAQKRQAQEEAERLRRQVQDESQ 1645

Query: 209  DLEWSE---------EVQKLQEQQLRSDLLDQYRSLLVERNRSQRYNLYLQHKIFEALRR 259
                +E         E +  +E+Q     L++ R    E  R  R          E  R 
Sbjct: 1646 RKRQAEVELASRVKAEAEAAREKQRALQALEELRLQAEEAERRLRQ--------AEVERA 1697

Query: 260  KKGLEAAEVADRGAEAEAPEKEQAYLRHLGMLEELKKQQADDLQWYHQELGQLKRQCQEK 319
            ++   A E A R AEAE   K  ++      LE         LQ  H  + QL+ + + +
Sbjct: 1698 RQVQVALETAQRSAEAELQSKRASFAEKTAQLER-------SLQEEHVAVAQLREEAERR 1750

Query: 320  L-TRVEKEWRRFQALKK----QVVMQAMGSCRMRGGRQAALREVEQIQALEDKKEKEMSA 374
               + E E  R +A ++    Q+        R++    A  + + Q +A + K+E E  A
Sbjct: 1751 AQQQAEAERAREEAERELERWQLKANEALRLRLQAEEVAQQKSLAQAEAEKQKEEAEREA 1810

Query: 375  VRLENIQLKQSLVHFETRMRTQEDLTQGLLLIDFEQLKIENQTFNEKIEERNEELLKLRS 434
             R    +        E  +R +E   Q L     +Q ++   T  +++    +EL++LR+
Sbjct: 1811 RRRGKAE--------EQAVRQRELAEQEL----EKQRQLAEGTAQQRL-AAEQELIRLRA 1857

Query: 435  KVTNSVQVITHVKEKLHFMDMENACKKTQLAEIEAQAALGRD----ILTKTKQAREGLRT 490
            +     Q    ++E+L  +  E A    +  E+EA+ A  R     +L    +A E  R+
Sbjct: 1858 ETEQGEQQRQLLEEELARLQREAAAATQKRQELEAELAKVRAEMEVLLASKARAEEESRS 1917

Query: 491  DNIRLNQKCGLLGKDSLLRDLEEKVDKTELL 521
             + +  Q+  L  +    R+L E+  +   L
Sbjct: 1918 TSEKSKQR--LEAEAGRFRELAEEAARLRAL 1946



 Score = 62.8 bits (151), Expect = 8e-10
 Identities = 99/447 (22%), Positives = 172/447 (38%), Gaps = 70/447 (15%)

Query: 119  ELEA----EAGAEELEQAAEGKEVRFQASLPLTRIDEEEAAAAPEAETERVEGEEEDKEE 174
            ELEA    +  AEE  +  E +E R Q SL      EEEAA   +A  E VE  +   EE
Sbjct: 2103 ELEAARQRQLAAEEERRRREAEE-RVQKSLAA----EEEAARQRKAALEEVERLKAKVEE 2157

Query: 175  TQRDGAESKERDGEGRPAKSQEEGKRLYGRDEFEDLEWSEEVQKLQEQ-QLRSDLLDQYR 233
             +R    +++          +   KRL   ++       ++ Q+LQ+  Q    +LDQ R
Sbjct: 2158 ARRLRERAEQESARQLQLAQEAAQKRLQAEEKAHAFAVQQKEQELQQTLQQEQSVLDQLR 2217

Query: 234  SLLVERNRSQRYNLYLQHKIFEALRRKKGLEAAEVADRGAEAEAPEKEQAYLRHLGMLEE 293
                                 EA   ++  E AE A   AE EA +  +           
Sbjct: 2218 G--------------------EAEAARRAAEEAEEARVQAEREAAQSRR----------- 2246

Query: 294  LKKQQADDLQWYHQELGQLKRQCQEKLTRVEKEWRRFQALKKQVVMQAMGSCRMRGGRQA 353
             + ++A+ L+   +E  Q + Q Q    ++ KE  +  A + Q               QA
Sbjct: 2247 -QVEEAERLKQSAEEQAQARAQAQAAAEKLRKEAEQEAARRAQ-------------AEQA 2292

Query: 354  ALREVEQIQALEDKKEKEMSAVRLENIQLKQSLVHFETRMRTQEDLTQGLLLIDFEQLK- 412
            ALR+ +   A  +K +K       +  Q++Q L     ++  + D  + LL  + ++LK 
Sbjct: 2293 ALRQKQAADAEMEKHKKFAEQTLRQKAQVEQELTTLRLQLE-ETDHQKNLLDEELQRLKA 2351

Query: 413  -----------IENQTFNEKIEERNEELLKLRSKVTNSVQVITHVKEKLHFMDMENACKK 461
                       +E + F+ +++      LK R +  N   ++        F+  E A K 
Sbjct: 2352 EATEAARQRSQVEEELFSVRVQMEELSKLKARIEAENRALILRDKDNTQRFL-QEEAEKM 2410

Query: 462  TQLAEIEAQAALGRDILTKTKQAREGLRTDNIRLNQKCGLLGKDSLLRDLEEKVDKTELL 521
             Q+AE  A+ ++      + +Q  E        L +K  L  K   +++      + ELL
Sbjct: 2411 KQVAEEAARLSVAAQEAARLRQLAEEDLAQQRALAEKM-LKEKMQAVQEATRLKAEAELL 2469

Query: 522  HRRLESLKRHHASLTLSCRGVRQKIRE 548
             ++ E  +     L      + Q++ E
Sbjct: 2470 QQQKELAQEQARRLQEDKEQMAQQLAE 2496



 Score = 62.8 bits (151), Expect = 8e-10
 Identities = 114/528 (21%), Positives = 218/528 (41%), Gaps = 53/528 (10%)

Query: 43   LESEPEEEEEEQAASQGGTAADEQAEAPKGLTAAEAAGEEGPGEPG----RPAEPQPEPE 98
            L+ E    ++ +  ++    A E+AE  +     EAA      E      + AE Q +  
Sbjct: 2206 LQQEQSVLDQLRGEAEAARRAAEEAEEARVQAEREAAQSRRQVEEAERLKQSAEEQAQAR 2265

Query: 99   EPAEVGAEEPAQPEPGAGPEELEAEAGAEELEQAAEGKEVRFQASLPLTRIDEEEAAAAP 158
              A+  AE+  +          +AE  A   +QAA+ +  + +     T    ++A    
Sbjct: 2266 AQAQAAAEKLRKEAEQEAARRAQAEQAALRQKQAADAEMEKHKKFAEQTL--RQKAQVEQ 2323

Query: 159  EAETERVEGEEEDKEETQRDGAESKERDGEGRPAKSQEEGKRLYGRDEFEDLEWSEEVQK 218
            E  T R++ EE D ++   D  E +    E   A  Q        R + E+  +S  VQ 
Sbjct: 2324 ELTTLRLQLEETDHQKNLLD-EELQRLKAEATEAARQ--------RSQVEEELFSVRVQM 2374

Query: 219  LQEQQLRSDLLDQYRSLLV-ERNRSQRYNLYLQHKIFEALRRKKGLEAAEVADRGAEAEA 277
             +  +L++ +  + R+L++ +++ +QR   +LQ    EA + K      +VA+  A    
Sbjct: 2375 EELSKLKARIEAENRALILRDKDNTQR---FLQE---EAEKMK------QVAEEAARLSV 2422

Query: 278  PEKEQAYLRHLGMLEELKKQQA------DDLQWYHQELGQLKRQC---QEKLTRVEKEWR 328
              +E A LR L   E+L +Q+A       +     QE  +LK +    Q++    +++ R
Sbjct: 2423 AAQEAARLRQLAE-EDLAQQRALAEKMLKEKMQAVQEATRLKAEAELLQQQKELAQEQAR 2481

Query: 329  RFQALKKQVVMQAMGSCRMRGGRQAALREVEQIQALEDKKEKEMSAVRLENIQLKQSLVH 388
            R Q  K+Q+  Q     +   G Q  L E E+ + LE   E E   +R+  +   Q+   
Sbjct: 2482 RLQEDKEQMAQQLAEETQ---GFQRTL-EAERQRQLEMSAEAERLKLRVAEMSRAQARAE 2537

Query: 389  FETRMRTQEDLTQGLLLIDFEQLKIENQTFNEKIEERNEELLKLRSKVTNSVQVITHVKE 448
             + +   ++    G  L   E    E  T  + +E + ++      ++  ++  +   KE
Sbjct: 2538 EDAQRFRKQAEEIGEKLHRTELATQEKVTLVQTLEIQRQQSDHDAERLREAIAELEREKE 2597

Query: 449  KLHFMDMENACKKTQLAEIEAQAALGRDILTKTKQAREGLRTDNIRLNQKCGLL--GKDS 506
            KL     +   K  QL   E Q      +L +T+  ++   ++   L Q+   +   K  
Sbjct: 2598 KL-----QQEAKLLQLKSEEMQTVQQEQLLQETQALQQSFLSEKDSLLQRERFIEQEKAK 2652

Query: 507  LLRDLEEKVDKTELL----HRRLESLKRHHASLTLSCRGVRQKIREAK 550
            L +  +++V K + L     R+ + +++    L  S    R++  EA+
Sbjct: 2653 LEQLFQDEVAKAQQLREEQQRQQQQMEQERQRLVASMEEARRRQHEAE 2700



 Score = 57.8 bits (138), Expect = 3e-08
 Identities = 120/542 (22%), Positives = 227/542 (41%), Gaps = 76/542 (14%)

Query: 43   LESEPEEEEEEQAASQGGTAADEQAEAPKGLTAAEAAGEEGPGEPG-RPAEPQPEPEEPA 101
            L+ EP  E  ++ A Q    A+ +    KG+    A  E+    P   PA P    E   
Sbjct: 1148 LDKEPARECAQRIAEQQKAQAEVEGLG-KGVARLSAEAEKVLALPEPSPAAPTLRSELEL 1206

Query: 102  EVGAEEPAQPEPGAGPEELEAEA-------GAEELEQAAEGKEVRFQASLPLTRIDEEEA 154
             +G  E  +       E+L+  +       GAEE+ +A E ++++   ++P T  + E  
Sbjct: 1207 TLGKLEQVRSLSAIYLEKLKTISLVIRGTQGAEEVLRAHE-EQLKEAQAVPATLPELE-- 1263

Query: 155  AAAPEAETERVEGEEEDKEETQRDGAESKERDGEGRPAKSQEEGKRLYGRDEFEDLE--- 211
              A +A  +++  + E ++ T  D    + R        +QE G+RL  R    D+E   
Sbjct: 1264 --ATKASLKKLRAQAEAQQPTF-DALRDELRG-------AQEVGERLQQRHGERDVEVER 1313

Query: 212  WSEEVQKLQEQ--------QLRSDLLDQY-RSLLVERNRSQRYNLYLQHKIFEALRRKKG 262
            W E V +L E+         +R   L+Q  R L   R  +     +LQ    +A RR++ 
Sbjct: 1314 WRERVAQLLERWQAVLAQTDVRQRELEQLGRQLRYYRESADPLGAWLQ----DARRRQEQ 1369

Query: 263  LEAAEVADRGAEAEAPEKEQAYL----RHLGMLEELK---KQQADDLQWYHQELGQLKRQ 315
            ++A  +AD  A  E   +EQA L    RH   +EE +   KQ  + ++ Y  +L   K Q
Sbjct: 1370 IQAMPLADSQAVREQLRQEQALLEEIERHGEKVEECQRFAKQYINAIKDYELQLVTYKAQ 1429

Query: 316  CQEKLTRVEKEWRRFQALKKQVVMQAMGSCRMRGGRQAAL--REVEQIQALEDKKEKEMS 373
             +   +  +K   + Q+  + V+ + +   R        L  + ++ I     + E+E  
Sbjct: 1430 LEPVASPAKKP--KVQSGSESVIQEYV-DLRTHYSELTTLTSQYIKFISETLRRMEEEER 1486

Query: 374  AVRLENIQLKQSLVHFETRMRTQEDLTQGLLLIDFEQLKIENQTFNEKIEER-NEELLKL 432
                +  + ++ L   E  +  Q  L +        Q K + +   +++++R  EE+++ 
Sbjct: 1487 LAEQQRAEERERLAEVEAALEKQRQLAEA-----HAQAKAQAEREAKELQQRMQEEVVRR 1541

Query: 433  RSKVTNSVQVITHVKEKLHFMDMENACKKTQLAEIEAQAALGRDILTKTKQAREGLRTDN 492
                 ++ Q    ++E+L  +      +++  AEI+A+A           +  E +R   
Sbjct: 1542 EEAAVDAQQQKRSIQEELQQL------RQSSEAEIQAKARQAEAAERSRLRIEEEIRVVR 1595

Query: 493  IRL----NQKCGLLGKDSLLRDLEEKV--------DKTELLHRRL--ESLKRHHASLTLS 538
            ++L     Q+ G  G+   LR   E+         ++ E L R++  ES ++  A + L+
Sbjct: 1596 LQLEATERQRGGAEGELQALRARAEEAEAQKRQAQEEAERLRRQVQDESQRKRQAEVELA 1655

Query: 539  CR 540
             R
Sbjct: 1656 SR 1657



 Score = 45.8 bits (107), Expect = 1e-04
 Identities = 86/441 (19%), Positives = 169/441 (38%), Gaps = 32/441 (7%)

Query: 42   ELESEPEEEEEEQAASQGGTAADEQAEAPKGLTAAEAAGEEGPGEPGRPAEPQPEPEEPA 101
            + E+E ++EE E+ A + G A +EQA   + L   E   +    E G   +     +E  
Sbjct: 1796 QAEAEKQKEEAEREARRRGKA-EEQAVRQRELAEQELEKQRQLAE-GTAQQRLAAEQELI 1853

Query: 102  EVGAE-EPAQPEPGAGPEEL---EAEAGA-----EELEQAAEGKEVRFQASLPLTRIDEE 152
             + AE E  + +     EEL   + EA A     +ELE          +  L      EE
Sbjct: 1854 RLRAETEQGEQQRQLLEEELARLQREAAAATQKRQELEAELAKVRAEMEVLLASKARAEE 1913

Query: 153  EAAAAPEAETERVEGEEEDKEETQRDGAESKERDGEGRPAKSQEEGKRLYGRDEFEDLEW 212
            E+ +  E   +R+E E     E   + A         R     EE KR          + 
Sbjct: 1914 ESRSTSEKSKQRLEAEAGRFRELAEEAA---------RLRALAEEAKR--------QRQL 1956

Query: 213  SEEVQKLQEQQLRSDLLDQYRSLLVERNRSQRYNLYLQHKIFEALRRKKGLEAAEVADRG 272
            +EE    Q  +    L ++  ++           + L+ K  E  R ++  E      R 
Sbjct: 1957 AEEDAARQRAEAERVLAEKLAAIGEATRLKTEAEIALKEKEAENERLRRLAEDEAFQRRR 2016

Query: 273  AEAEAPEKEQAYLRHLGMLEELKKQQADDLQWYHQELGQLKRQCQEKLTRVEKEWRRFQA 332
             E +A + +      L  L +    + +  +   ++  + +RQ +E++  ++  + +  A
Sbjct: 2017 LEEQAAQHKADIEERLAQLRKASDSELERQKGLVEDTLRQRRQVEEEILALKASFEKAAA 2076

Query: 333  LKKQVVMQAMGSCRMRGGRQAALREVEQIQALEDKKEKEMSAVRLENIQLKQSLVHFETR 392
             K ++ ++ +G  R+R   +  LR  EQ + LE  ++++++A      +  +  V     
Sbjct: 2077 GKAELELE-LG--RIRSNAEDTLRSKEQAE-LEAARQRQLAAEEERRRREAEERVQKSLA 2132

Query: 393  MRTQEDLTQGLLLIDFEQLKIENQTFNEKIEERNEELLKLRSKVTNSVQVITHVKEKLHF 452
               +    +   L + E+LK + +      E   +E  +       + Q     +EK H 
Sbjct: 2133 AEEEAARQRKAALEEVERLKAKVEEARRLRERAEQESARQLQLAQEAAQKRLQAEEKAHA 2192

Query: 453  MDMENACKKTQLAEIEAQAAL 473
              ++   ++ Q    + Q+ L
Sbjct: 2193 FAVQQKEQELQQTLQQEQSVL 2213



 Score = 32.3 bits (72), Expect = 1.2
 Identities = 27/102 (26%), Positives = 54/102 (52%), Gaps = 9/102 (8%)

Query: 141  QASLPLTRIDEEEAAAAPEAETERVEGEEEDKEETQR-----DGAESKERDGEGRPAKSQ 195
            Q    L ++ ++E A A +   E+   +++ ++E QR     + A  ++ + E    + Q
Sbjct: 2648 QEKAKLEQLFQDEVAKAQQLREEQQRQQQQMEQERQRLVASMEEARRRQHEAEEGVRRKQ 2707

Query: 196  EEGKRLYGRDEFEDLEWSEEVQKLQEQ-QLRSDLLDQYRSLL 236
            EE ++L  +   ++   +EE Q+L+EQ QL   L +Q+R+ L
Sbjct: 2708 EELQQLEQQRRQQEELLAEENQRLREQLQL---LEEQHRAAL 2746


>gi|41322908 plectin 1 isoform 3 [Homo sapiens]
          Length = 4525

 Score = 75.1 bits (183), Expect = 2e-13
 Identities = 121/511 (23%), Positives = 206/511 (40%), Gaps = 85/511 (16%)

Query: 50   EEEEQAASQGGTAADEQAEAPKGLTAAEAAGEE----GPGEPGRPAEPQPEPEEPAEVGA 105
            EEEE+ A Q      ++AE  + L   EAA E+            A+ + E +E  +   
Sbjct: 1323 EEEERLAEQ------QRAEERERLAEVEAALEKQRQLAEAHAQAKAQAEREAKELQQRMQ 1376

Query: 106  EEPAQPEPGAGPEELEAEAGAEELEQAAEGKEVRFQASLPLTRIDEEEAAAAPEAETERV 165
            EE  + E  A   + +  +  EEL+Q  +  E   QA          +A  A  AE  R+
Sbjct: 1377 EEVVRREEAAVDAQQQKRSIQEELQQLRQSSEAEIQA----------KARQAEAAERSRL 1426

Query: 166  EGEEE--------DKEETQRDGAE-------SKERDGEGRPAKSQEEGKRL--YGRDEFE 208
              EEE        +  E QR GAE       ++  + E +  ++QEE +RL    +DE +
Sbjct: 1427 RIEEEIRVVRLQLEATERQRGGAEGELQALRARAEEAEAQKRQAQEEAERLRRQVQDESQ 1486

Query: 209  DLEWSE---------EVQKLQEQQLRSDLLDQYRSLLVERNRSQRYNLYLQHKIFEALRR 259
                +E         E +  +E+Q     L++ R    E  R  R          E  R 
Sbjct: 1487 RKRQAEVELASRVKAEAEAAREKQRALQALEELRLQAEEAERRLRQ--------AEVERA 1538

Query: 260  KKGLEAAEVADRGAEAEAPEKEQAYLRHLGMLEELKKQQADDLQWYHQELGQLKRQCQEK 319
            ++   A E A R AEAE   K  ++      LE         LQ  H  + QL+ + + +
Sbjct: 1539 RQVQVALETAQRSAEAELQSKRASFAEKTAQLER-------SLQEEHVAVAQLREEAERR 1591

Query: 320  L-TRVEKEWRRFQALKK----QVVMQAMGSCRMRGGRQAALREVEQIQALEDKKEKEMSA 374
               + E E  R +A ++    Q+        R++    A  + + Q +A + K+E E  A
Sbjct: 1592 AQQQAEAERAREEAERELERWQLKANEALRLRLQAEEVAQQKSLAQAEAEKQKEEAEREA 1651

Query: 375  VRLENIQLKQSLVHFETRMRTQEDLTQGLLLIDFEQLKIENQTFNEKIEERNEELLKLRS 434
             R    +        E  +R +E   Q L     +Q ++   T  +++    +EL++LR+
Sbjct: 1652 RRRGKAE--------EQAVRQRELAEQEL----EKQRQLAEGTAQQRL-AAEQELIRLRA 1698

Query: 435  KVTNSVQVITHVKEKLHFMDMENACKKTQLAEIEAQAALGRD----ILTKTKQAREGLRT 490
            +     Q    ++E+L  +  E A    +  E+EA+ A  R     +L    +A E  R+
Sbjct: 1699 ETEQGEQQRQLLEEELARLQREAAAATQKRQELEAELAKVRAEMEVLLASKARAEEESRS 1758

Query: 491  DNIRLNQKCGLLGKDSLLRDLEEKVDKTELL 521
             + +  Q+  L  +    R+L E+  +   L
Sbjct: 1759 TSEKSKQR--LEAEAGRFRELAEEAARLRAL 1787



 Score = 62.8 bits (151), Expect = 8e-10
 Identities = 99/447 (22%), Positives = 172/447 (38%), Gaps = 70/447 (15%)

Query: 119  ELEA----EAGAEELEQAAEGKEVRFQASLPLTRIDEEEAAAAPEAETERVEGEEEDKEE 174
            ELEA    +  AEE  +  E +E R Q SL      EEEAA   +A  E VE  +   EE
Sbjct: 1944 ELEAARQRQLAAEEERRRREAEE-RVQKSLAA----EEEAARQRKAALEEVERLKAKVEE 1998

Query: 175  TQRDGAESKERDGEGRPAKSQEEGKRLYGRDEFEDLEWSEEVQKLQEQ-QLRSDLLDQYR 233
             +R    +++          +   KRL   ++       ++ Q+LQ+  Q    +LDQ R
Sbjct: 1999 ARRLRERAEQESARQLQLAQEAAQKRLQAEEKAHAFAVQQKEQELQQTLQQEQSVLDQLR 2058

Query: 234  SLLVERNRSQRYNLYLQHKIFEALRRKKGLEAAEVADRGAEAEAPEKEQAYLRHLGMLEE 293
                                 EA   ++  E AE A   AE EA +  +           
Sbjct: 2059 G--------------------EAEAARRAAEEAEEARVQAEREAAQSRR----------- 2087

Query: 294  LKKQQADDLQWYHQELGQLKRQCQEKLTRVEKEWRRFQALKKQVVMQAMGSCRMRGGRQA 353
             + ++A+ L+   +E  Q + Q Q    ++ KE  +  A + Q               QA
Sbjct: 2088 -QVEEAERLKQSAEEQAQARAQAQAAAEKLRKEAEQEAARRAQ-------------AEQA 2133

Query: 354  ALREVEQIQALEDKKEKEMSAVRLENIQLKQSLVHFETRMRTQEDLTQGLLLIDFEQLK- 412
            ALR+ +   A  +K +K       +  Q++Q L     ++  + D  + LL  + ++LK 
Sbjct: 2134 ALRQKQAADAEMEKHKKFAEQTLRQKAQVEQELTTLRLQLE-ETDHQKNLLDEELQRLKA 2192

Query: 413  -----------IENQTFNEKIEERNEELLKLRSKVTNSVQVITHVKEKLHFMDMENACKK 461
                       +E + F+ +++      LK R +  N   ++        F+  E A K 
Sbjct: 2193 EATEAARQRSQVEEELFSVRVQMEELSKLKARIEAENRALILRDKDNTQRFL-QEEAEKM 2251

Query: 462  TQLAEIEAQAALGRDILTKTKQAREGLRTDNIRLNQKCGLLGKDSLLRDLEEKVDKTELL 521
             Q+AE  A+ ++      + +Q  E        L +K  L  K   +++      + ELL
Sbjct: 2252 KQVAEEAARLSVAAQEAARLRQLAEEDLAQQRALAEKM-LKEKMQAVQEATRLKAEAELL 2310

Query: 522  HRRLESLKRHHASLTLSCRGVRQKIRE 548
             ++ E  +     L      + Q++ E
Sbjct: 2311 QQQKELAQEQARRLQEDKEQMAQQLAE 2337



 Score = 62.8 bits (151), Expect = 8e-10
 Identities = 114/528 (21%), Positives = 218/528 (41%), Gaps = 53/528 (10%)

Query: 43   LESEPEEEEEEQAASQGGTAADEQAEAPKGLTAAEAAGEEGPGEPG----RPAEPQPEPE 98
            L+ E    ++ +  ++    A E+AE  +     EAA      E      + AE Q +  
Sbjct: 2047 LQQEQSVLDQLRGEAEAARRAAEEAEEARVQAEREAAQSRRQVEEAERLKQSAEEQAQAR 2106

Query: 99   EPAEVGAEEPAQPEPGAGPEELEAEAGAEELEQAAEGKEVRFQASLPLTRIDEEEAAAAP 158
              A+  AE+  +          +AE  A   +QAA+ +  + +     T    ++A    
Sbjct: 2107 AQAQAAAEKLRKEAEQEAARRAQAEQAALRQKQAADAEMEKHKKFAEQTL--RQKAQVEQ 2164

Query: 159  EAETERVEGEEEDKEETQRDGAESKERDGEGRPAKSQEEGKRLYGRDEFEDLEWSEEVQK 218
            E  T R++ EE D ++   D  E +    E   A  Q        R + E+  +S  VQ 
Sbjct: 2165 ELTTLRLQLEETDHQKNLLD-EELQRLKAEATEAARQ--------RSQVEEELFSVRVQM 2215

Query: 219  LQEQQLRSDLLDQYRSLLV-ERNRSQRYNLYLQHKIFEALRRKKGLEAAEVADRGAEAEA 277
             +  +L++ +  + R+L++ +++ +QR   +LQ    EA + K      +VA+  A    
Sbjct: 2216 EELSKLKARIEAENRALILRDKDNTQR---FLQE---EAEKMK------QVAEEAARLSV 2263

Query: 278  PEKEQAYLRHLGMLEELKKQQA------DDLQWYHQELGQLKRQC---QEKLTRVEKEWR 328
              +E A LR L   E+L +Q+A       +     QE  +LK +    Q++    +++ R
Sbjct: 2264 AAQEAARLRQLAE-EDLAQQRALAEKMLKEKMQAVQEATRLKAEAELLQQQKELAQEQAR 2322

Query: 329  RFQALKKQVVMQAMGSCRMRGGRQAALREVEQIQALEDKKEKEMSAVRLENIQLKQSLVH 388
            R Q  K+Q+  Q     +   G Q  L E E+ + LE   E E   +R+  +   Q+   
Sbjct: 2323 RLQEDKEQMAQQLAEETQ---GFQRTL-EAERQRQLEMSAEAERLKLRVAEMSRAQARAE 2378

Query: 389  FETRMRTQEDLTQGLLLIDFEQLKIENQTFNEKIEERNEELLKLRSKVTNSVQVITHVKE 448
             + +   ++    G  L   E    E  T  + +E + ++      ++  ++  +   KE
Sbjct: 2379 EDAQRFRKQAEEIGEKLHRTELATQEKVTLVQTLEIQRQQSDHDAERLREAIAELEREKE 2438

Query: 449  KLHFMDMENACKKTQLAEIEAQAALGRDILTKTKQAREGLRTDNIRLNQKCGLL--GKDS 506
            KL     +   K  QL   E Q      +L +T+  ++   ++   L Q+   +   K  
Sbjct: 2439 KL-----QQEAKLLQLKSEEMQTVQQEQLLQETQALQQSFLSEKDSLLQRERFIEQEKAK 2493

Query: 507  LLRDLEEKVDKTELL----HRRLESLKRHHASLTLSCRGVRQKIREAK 550
            L +  +++V K + L     R+ + +++    L  S    R++  EA+
Sbjct: 2494 LEQLFQDEVAKAQQLREEQQRQQQQMEQERQRLVASMEEARRRQHEAE 2541



 Score = 57.8 bits (138), Expect = 3e-08
 Identities = 120/542 (22%), Positives = 227/542 (41%), Gaps = 76/542 (14%)

Query: 43   LESEPEEEEEEQAASQGGTAADEQAEAPKGLTAAEAAGEEGPGEPG-RPAEPQPEPEEPA 101
            L+ EP  E  ++ A Q    A+ +    KG+    A  E+    P   PA P    E   
Sbjct: 989  LDKEPARECAQRIAEQQKAQAEVEGLG-KGVARLSAEAEKVLALPEPSPAAPTLRSELEL 1047

Query: 102  EVGAEEPAQPEPGAGPEELEAEA-------GAEELEQAAEGKEVRFQASLPLTRIDEEEA 154
             +G  E  +       E+L+  +       GAEE+ +A E ++++   ++P T  + E  
Sbjct: 1048 TLGKLEQVRSLSAIYLEKLKTISLVIRGTQGAEEVLRAHE-EQLKEAQAVPATLPELE-- 1104

Query: 155  AAAPEAETERVEGEEEDKEETQRDGAESKERDGEGRPAKSQEEGKRLYGRDEFEDLE--- 211
              A +A  +++  + E ++ T  D    + R        +QE G+RL  R    D+E   
Sbjct: 1105 --ATKASLKKLRAQAEAQQPTF-DALRDELRG-------AQEVGERLQQRHGERDVEVER 1154

Query: 212  WSEEVQKLQEQ--------QLRSDLLDQY-RSLLVERNRSQRYNLYLQHKIFEALRRKKG 262
            W E V +L E+         +R   L+Q  R L   R  +     +LQ    +A RR++ 
Sbjct: 1155 WRERVAQLLERWQAVLAQTDVRQRELEQLGRQLRYYRESADPLGAWLQ----DARRRQEQ 1210

Query: 263  LEAAEVADRGAEAEAPEKEQAYL----RHLGMLEELK---KQQADDLQWYHQELGQLKRQ 315
            ++A  +AD  A  E   +EQA L    RH   +EE +   KQ  + ++ Y  +L   K Q
Sbjct: 1211 IQAMPLADSQAVREQLRQEQALLEEIERHGEKVEECQRFAKQYINAIKDYELQLVTYKAQ 1270

Query: 316  CQEKLTRVEKEWRRFQALKKQVVMQAMGSCRMRGGRQAAL--REVEQIQALEDKKEKEMS 373
             +   +  +K   + Q+  + V+ + +   R        L  + ++ I     + E+E  
Sbjct: 1271 LEPVASPAKKP--KVQSGSESVIQEYV-DLRTHYSELTTLTSQYIKFISETLRRMEEEER 1327

Query: 374  AVRLENIQLKQSLVHFETRMRTQEDLTQGLLLIDFEQLKIENQTFNEKIEER-NEELLKL 432
                +  + ++ L   E  +  Q  L +        Q K + +   +++++R  EE+++ 
Sbjct: 1328 LAEQQRAEERERLAEVEAALEKQRQLAEA-----HAQAKAQAEREAKELQQRMQEEVVRR 1382

Query: 433  RSKVTNSVQVITHVKEKLHFMDMENACKKTQLAEIEAQAALGRDILTKTKQAREGLRTDN 492
                 ++ Q    ++E+L  +      +++  AEI+A+A           +  E +R   
Sbjct: 1383 EEAAVDAQQQKRSIQEELQQL------RQSSEAEIQAKARQAEAAERSRLRIEEEIRVVR 1436

Query: 493  IRL----NQKCGLLGKDSLLRDLEEKV--------DKTELLHRRL--ESLKRHHASLTLS 538
            ++L     Q+ G  G+   LR   E+         ++ E L R++  ES ++  A + L+
Sbjct: 1437 LQLEATERQRGGAEGELQALRARAEEAEAQKRQAQEEAERLRRQVQDESQRKRQAEVELA 1496

Query: 539  CR 540
             R
Sbjct: 1497 SR 1498



 Score = 45.8 bits (107), Expect = 1e-04
 Identities = 86/441 (19%), Positives = 169/441 (38%), Gaps = 32/441 (7%)

Query: 42   ELESEPEEEEEEQAASQGGTAADEQAEAPKGLTAAEAAGEEGPGEPGRPAEPQPEPEEPA 101
            + E+E ++EE E+ A + G A +EQA   + L   E   +    E G   +     +E  
Sbjct: 1637 QAEAEKQKEEAEREARRRGKA-EEQAVRQRELAEQELEKQRQLAE-GTAQQRLAAEQELI 1694

Query: 102  EVGAE-EPAQPEPGAGPEEL---EAEAGA-----EELEQAAEGKEVRFQASLPLTRIDEE 152
             + AE E  + +     EEL   + EA A     +ELE          +  L      EE
Sbjct: 1695 RLRAETEQGEQQRQLLEEELARLQREAAAATQKRQELEAELAKVRAEMEVLLASKARAEE 1754

Query: 153  EAAAAPEAETERVEGEEEDKEETQRDGAESKERDGEGRPAKSQEEGKRLYGRDEFEDLEW 212
            E+ +  E   +R+E E     E   + A         R     EE KR          + 
Sbjct: 1755 ESRSTSEKSKQRLEAEAGRFRELAEEAA---------RLRALAEEAKR--------QRQL 1797

Query: 213  SEEVQKLQEQQLRSDLLDQYRSLLVERNRSQRYNLYLQHKIFEALRRKKGLEAAEVADRG 272
            +EE    Q  +    L ++  ++           + L+ K  E  R ++  E      R 
Sbjct: 1798 AEEDAARQRAEAERVLAEKLAAIGEATRLKTEAEIALKEKEAENERLRRLAEDEAFQRRR 1857

Query: 273  AEAEAPEKEQAYLRHLGMLEELKKQQADDLQWYHQELGQLKRQCQEKLTRVEKEWRRFQA 332
             E +A + +      L  L +    + +  +   ++  + +RQ +E++  ++  + +  A
Sbjct: 1858 LEEQAAQHKADIEERLAQLRKASDSELERQKGLVEDTLRQRRQVEEEILALKASFEKAAA 1917

Query: 333  LKKQVVMQAMGSCRMRGGRQAALREVEQIQALEDKKEKEMSAVRLENIQLKQSLVHFETR 392
             K ++ ++ +G  R+R   +  LR  EQ + LE  ++++++A      +  +  V     
Sbjct: 1918 GKAELELE-LG--RIRSNAEDTLRSKEQAE-LEAARQRQLAAEEERRRREAEERVQKSLA 1973

Query: 393  MRTQEDLTQGLLLIDFEQLKIENQTFNEKIEERNEELLKLRSKVTNSVQVITHVKEKLHF 452
               +    +   L + E+LK + +      E   +E  +       + Q     +EK H 
Sbjct: 1974 AEEEAARQRKAALEEVERLKAKVEEARRLRERAEQESARQLQLAQEAAQKRLQAEEKAHA 2033

Query: 453  MDMENACKKTQLAEIEAQAAL 473
              ++   ++ Q    + Q+ L
Sbjct: 2034 FAVQQKEQELQQTLQQEQSVL 2054



 Score = 32.3 bits (72), Expect = 1.2
 Identities = 27/102 (26%), Positives = 54/102 (52%), Gaps = 9/102 (8%)

Query: 141  QASLPLTRIDEEEAAAAPEAETERVEGEEEDKEETQR-----DGAESKERDGEGRPAKSQ 195
            Q    L ++ ++E A A +   E+   +++ ++E QR     + A  ++ + E    + Q
Sbjct: 2489 QEKAKLEQLFQDEVAKAQQLREEQQRQQQQMEQERQRLVASMEEARRRQHEAEEGVRRKQ 2548

Query: 196  EEGKRLYGRDEFEDLEWSEEVQKLQEQ-QLRSDLLDQYRSLL 236
            EE ++L  +   ++   +EE Q+L+EQ QL   L +Q+R+ L
Sbjct: 2549 EELQQLEQQRRQQEELLAEENQRLREQLQL---LEEQHRAAL 2587


>gi|41322912 plectin 1 isoform 2 [Homo sapiens]
          Length = 4533

 Score = 75.1 bits (183), Expect = 2e-13
 Identities = 121/511 (23%), Positives = 206/511 (40%), Gaps = 85/511 (16%)

Query: 50   EEEEQAASQGGTAADEQAEAPKGLTAAEAAGEE----GPGEPGRPAEPQPEPEEPAEVGA 105
            EEEE+ A Q      ++AE  + L   EAA E+            A+ + E +E  +   
Sbjct: 1331 EEEERLAEQ------QRAEERERLAEVEAALEKQRQLAEAHAQAKAQAEREAKELQQRMQ 1384

Query: 106  EEPAQPEPGAGPEELEAEAGAEELEQAAEGKEVRFQASLPLTRIDEEEAAAAPEAETERV 165
            EE  + E  A   + +  +  EEL+Q  +  E   QA          +A  A  AE  R+
Sbjct: 1385 EEVVRREEAAVDAQQQKRSIQEELQQLRQSSEAEIQA----------KARQAEAAERSRL 1434

Query: 166  EGEEE--------DKEETQRDGAE-------SKERDGEGRPAKSQEEGKRL--YGRDEFE 208
              EEE        +  E QR GAE       ++  + E +  ++QEE +RL    +DE +
Sbjct: 1435 RIEEEIRVVRLQLEATERQRGGAEGELQALRARAEEAEAQKRQAQEEAERLRRQVQDESQ 1494

Query: 209  DLEWSE---------EVQKLQEQQLRSDLLDQYRSLLVERNRSQRYNLYLQHKIFEALRR 259
                +E         E +  +E+Q     L++ R    E  R  R          E  R 
Sbjct: 1495 RKRQAEVELASRVKAEAEAAREKQRALQALEELRLQAEEAERRLRQ--------AEVERA 1546

Query: 260  KKGLEAAEVADRGAEAEAPEKEQAYLRHLGMLEELKKQQADDLQWYHQELGQLKRQCQEK 319
            ++   A E A R AEAE   K  ++      LE         LQ  H  + QL+ + + +
Sbjct: 1547 RQVQVALETAQRSAEAELQSKRASFAEKTAQLER-------SLQEEHVAVAQLREEAERR 1599

Query: 320  L-TRVEKEWRRFQALKK----QVVMQAMGSCRMRGGRQAALREVEQIQALEDKKEKEMSA 374
               + E E  R +A ++    Q+        R++    A  + + Q +A + K+E E  A
Sbjct: 1600 AQQQAEAERAREEAERELERWQLKANEALRLRLQAEEVAQQKSLAQAEAEKQKEEAEREA 1659

Query: 375  VRLENIQLKQSLVHFETRMRTQEDLTQGLLLIDFEQLKIENQTFNEKIEERNEELLKLRS 434
             R    +        E  +R +E   Q L     +Q ++   T  +++    +EL++LR+
Sbjct: 1660 RRRGKAE--------EQAVRQRELAEQEL----EKQRQLAEGTAQQRL-AAEQELIRLRA 1706

Query: 435  KVTNSVQVITHVKEKLHFMDMENACKKTQLAEIEAQAALGRD----ILTKTKQAREGLRT 490
            +     Q    ++E+L  +  E A    +  E+EA+ A  R     +L    +A E  R+
Sbjct: 1707 ETEQGEQQRQLLEEELARLQREAAAATQKRQELEAELAKVRAEMEVLLASKARAEEESRS 1766

Query: 491  DNIRLNQKCGLLGKDSLLRDLEEKVDKTELL 521
             + +  Q+  L  +    R+L E+  +   L
Sbjct: 1767 TSEKSKQR--LEAEAGRFRELAEEAARLRAL 1795



 Score = 62.8 bits (151), Expect = 8e-10
 Identities = 99/447 (22%), Positives = 172/447 (38%), Gaps = 70/447 (15%)

Query: 119  ELEA----EAGAEELEQAAEGKEVRFQASLPLTRIDEEEAAAAPEAETERVEGEEEDKEE 174
            ELEA    +  AEE  +  E +E R Q SL      EEEAA   +A  E VE  +   EE
Sbjct: 1952 ELEAARQRQLAAEEERRRREAEE-RVQKSLAA----EEEAARQRKAALEEVERLKAKVEE 2006

Query: 175  TQRDGAESKERDGEGRPAKSQEEGKRLYGRDEFEDLEWSEEVQKLQEQ-QLRSDLLDQYR 233
             +R    +++          +   KRL   ++       ++ Q+LQ+  Q    +LDQ R
Sbjct: 2007 ARRLRERAEQESARQLQLAQEAAQKRLQAEEKAHAFAVQQKEQELQQTLQQEQSVLDQLR 2066

Query: 234  SLLVERNRSQRYNLYLQHKIFEALRRKKGLEAAEVADRGAEAEAPEKEQAYLRHLGMLEE 293
                                 EA   ++  E AE A   AE EA +  +           
Sbjct: 2067 G--------------------EAEAARRAAEEAEEARVQAEREAAQSRR----------- 2095

Query: 294  LKKQQADDLQWYHQELGQLKRQCQEKLTRVEKEWRRFQALKKQVVMQAMGSCRMRGGRQA 353
             + ++A+ L+   +E  Q + Q Q    ++ KE  +  A + Q               QA
Sbjct: 2096 -QVEEAERLKQSAEEQAQARAQAQAAAEKLRKEAEQEAARRAQ-------------AEQA 2141

Query: 354  ALREVEQIQALEDKKEKEMSAVRLENIQLKQSLVHFETRMRTQEDLTQGLLLIDFEQLK- 412
            ALR+ +   A  +K +K       +  Q++Q L     ++  + D  + LL  + ++LK 
Sbjct: 2142 ALRQKQAADAEMEKHKKFAEQTLRQKAQVEQELTTLRLQLE-ETDHQKNLLDEELQRLKA 2200

Query: 413  -----------IENQTFNEKIEERNEELLKLRSKVTNSVQVITHVKEKLHFMDMENACKK 461
                       +E + F+ +++      LK R +  N   ++        F+  E A K 
Sbjct: 2201 EATEAARQRSQVEEELFSVRVQMEELSKLKARIEAENRALILRDKDNTQRFL-QEEAEKM 2259

Query: 462  TQLAEIEAQAALGRDILTKTKQAREGLRTDNIRLNQKCGLLGKDSLLRDLEEKVDKTELL 521
             Q+AE  A+ ++      + +Q  E        L +K  L  K   +++      + ELL
Sbjct: 2260 KQVAEEAARLSVAAQEAARLRQLAEEDLAQQRALAEKM-LKEKMQAVQEATRLKAEAELL 2318

Query: 522  HRRLESLKRHHASLTLSCRGVRQKIRE 548
             ++ E  +     L      + Q++ E
Sbjct: 2319 QQQKELAQEQARRLQEDKEQMAQQLAE 2345



 Score = 62.8 bits (151), Expect = 8e-10
 Identities = 114/528 (21%), Positives = 218/528 (41%), Gaps = 53/528 (10%)

Query: 43   LESEPEEEEEEQAASQGGTAADEQAEAPKGLTAAEAAGEEGPGEPG----RPAEPQPEPE 98
            L+ E    ++ +  ++    A E+AE  +     EAA      E      + AE Q +  
Sbjct: 2055 LQQEQSVLDQLRGEAEAARRAAEEAEEARVQAEREAAQSRRQVEEAERLKQSAEEQAQAR 2114

Query: 99   EPAEVGAEEPAQPEPGAGPEELEAEAGAEELEQAAEGKEVRFQASLPLTRIDEEEAAAAP 158
              A+  AE+  +          +AE  A   +QAA+ +  + +     T    ++A    
Sbjct: 2115 AQAQAAAEKLRKEAEQEAARRAQAEQAALRQKQAADAEMEKHKKFAEQTL--RQKAQVEQ 2172

Query: 159  EAETERVEGEEEDKEETQRDGAESKERDGEGRPAKSQEEGKRLYGRDEFEDLEWSEEVQK 218
            E  T R++ EE D ++   D  E +    E   A  Q        R + E+  +S  VQ 
Sbjct: 2173 ELTTLRLQLEETDHQKNLLD-EELQRLKAEATEAARQ--------RSQVEEELFSVRVQM 2223

Query: 219  LQEQQLRSDLLDQYRSLLV-ERNRSQRYNLYLQHKIFEALRRKKGLEAAEVADRGAEAEA 277
             +  +L++ +  + R+L++ +++ +QR   +LQ    EA + K      +VA+  A    
Sbjct: 2224 EELSKLKARIEAENRALILRDKDNTQR---FLQE---EAEKMK------QVAEEAARLSV 2271

Query: 278  PEKEQAYLRHLGMLEELKKQQA------DDLQWYHQELGQLKRQC---QEKLTRVEKEWR 328
              +E A LR L   E+L +Q+A       +     QE  +LK +    Q++    +++ R
Sbjct: 2272 AAQEAARLRQLAE-EDLAQQRALAEKMLKEKMQAVQEATRLKAEAELLQQQKELAQEQAR 2330

Query: 329  RFQALKKQVVMQAMGSCRMRGGRQAALREVEQIQALEDKKEKEMSAVRLENIQLKQSLVH 388
            R Q  K+Q+  Q     +   G Q  L E E+ + LE   E E   +R+  +   Q+   
Sbjct: 2331 RLQEDKEQMAQQLAEETQ---GFQRTL-EAERQRQLEMSAEAERLKLRVAEMSRAQARAE 2386

Query: 389  FETRMRTQEDLTQGLLLIDFEQLKIENQTFNEKIEERNEELLKLRSKVTNSVQVITHVKE 448
             + +   ++    G  L   E    E  T  + +E + ++      ++  ++  +   KE
Sbjct: 2387 EDAQRFRKQAEEIGEKLHRTELATQEKVTLVQTLEIQRQQSDHDAERLREAIAELEREKE 2446

Query: 449  KLHFMDMENACKKTQLAEIEAQAALGRDILTKTKQAREGLRTDNIRLNQKCGLL--GKDS 506
            KL     +   K  QL   E Q      +L +T+  ++   ++   L Q+   +   K  
Sbjct: 2447 KL-----QQEAKLLQLKSEEMQTVQQEQLLQETQALQQSFLSEKDSLLQRERFIEQEKAK 2501

Query: 507  LLRDLEEKVDKTELL----HRRLESLKRHHASLTLSCRGVRQKIREAK 550
            L +  +++V K + L     R+ + +++    L  S    R++  EA+
Sbjct: 2502 LEQLFQDEVAKAQQLREEQQRQQQQMEQERQRLVASMEEARRRQHEAE 2549



 Score = 57.8 bits (138), Expect = 3e-08
 Identities = 120/542 (22%), Positives = 227/542 (41%), Gaps = 76/542 (14%)

Query: 43   LESEPEEEEEEQAASQGGTAADEQAEAPKGLTAAEAAGEEGPGEPG-RPAEPQPEPEEPA 101
            L+ EP  E  ++ A Q    A+ +    KG+    A  E+    P   PA P    E   
Sbjct: 997  LDKEPARECAQRIAEQQKAQAEVEGLG-KGVARLSAEAEKVLALPEPSPAAPTLRSELEL 1055

Query: 102  EVGAEEPAQPEPGAGPEELEAEA-------GAEELEQAAEGKEVRFQASLPLTRIDEEEA 154
             +G  E  +       E+L+  +       GAEE+ +A E ++++   ++P T  + E  
Sbjct: 1056 TLGKLEQVRSLSAIYLEKLKTISLVIRGTQGAEEVLRAHE-EQLKEAQAVPATLPELE-- 1112

Query: 155  AAAPEAETERVEGEEEDKEETQRDGAESKERDGEGRPAKSQEEGKRLYGRDEFEDLE--- 211
              A +A  +++  + E ++ T  D    + R        +QE G+RL  R    D+E   
Sbjct: 1113 --ATKASLKKLRAQAEAQQPTF-DALRDELRG-------AQEVGERLQQRHGERDVEVER 1162

Query: 212  WSEEVQKLQEQ--------QLRSDLLDQY-RSLLVERNRSQRYNLYLQHKIFEALRRKKG 262
            W E V +L E+         +R   L+Q  R L   R  +     +LQ    +A RR++ 
Sbjct: 1163 WRERVAQLLERWQAVLAQTDVRQRELEQLGRQLRYYRESADPLGAWLQ----DARRRQEQ 1218

Query: 263  LEAAEVADRGAEAEAPEKEQAYL----RHLGMLEELK---KQQADDLQWYHQELGQLKRQ 315
            ++A  +AD  A  E   +EQA L    RH   +EE +   KQ  + ++ Y  +L   K Q
Sbjct: 1219 IQAMPLADSQAVREQLRQEQALLEEIERHGEKVEECQRFAKQYINAIKDYELQLVTYKAQ 1278

Query: 316  CQEKLTRVEKEWRRFQALKKQVVMQAMGSCRMRGGRQAAL--REVEQIQALEDKKEKEMS 373
             +   +  +K   + Q+  + V+ + +   R        L  + ++ I     + E+E  
Sbjct: 1279 LEPVASPAKKP--KVQSGSESVIQEYV-DLRTHYSELTTLTSQYIKFISETLRRMEEEER 1335

Query: 374  AVRLENIQLKQSLVHFETRMRTQEDLTQGLLLIDFEQLKIENQTFNEKIEER-NEELLKL 432
                +  + ++ L   E  +  Q  L +        Q K + +   +++++R  EE+++ 
Sbjct: 1336 LAEQQRAEERERLAEVEAALEKQRQLAEA-----HAQAKAQAEREAKELQQRMQEEVVRR 1390

Query: 433  RSKVTNSVQVITHVKEKLHFMDMENACKKTQLAEIEAQAALGRDILTKTKQAREGLRTDN 492
                 ++ Q    ++E+L  +      +++  AEI+A+A           +  E +R   
Sbjct: 1391 EEAAVDAQQQKRSIQEELQQL------RQSSEAEIQAKARQAEAAERSRLRIEEEIRVVR 1444

Query: 493  IRL----NQKCGLLGKDSLLRDLEEKV--------DKTELLHRRL--ESLKRHHASLTLS 538
            ++L     Q+ G  G+   LR   E+         ++ E L R++  ES ++  A + L+
Sbjct: 1445 LQLEATERQRGGAEGELQALRARAEEAEAQKRQAQEEAERLRRQVQDESQRKRQAEVELA 1504

Query: 539  CR 540
             R
Sbjct: 1505 SR 1506



 Score = 45.8 bits (107), Expect = 1e-04
 Identities = 86/441 (19%), Positives = 169/441 (38%), Gaps = 32/441 (7%)

Query: 42   ELESEPEEEEEEQAASQGGTAADEQAEAPKGLTAAEAAGEEGPGEPGRPAEPQPEPEEPA 101
            + E+E ++EE E+ A + G A +EQA   + L   E   +    E G   +     +E  
Sbjct: 1645 QAEAEKQKEEAEREARRRGKA-EEQAVRQRELAEQELEKQRQLAE-GTAQQRLAAEQELI 1702

Query: 102  EVGAE-EPAQPEPGAGPEEL---EAEAGA-----EELEQAAEGKEVRFQASLPLTRIDEE 152
             + AE E  + +     EEL   + EA A     +ELE          +  L      EE
Sbjct: 1703 RLRAETEQGEQQRQLLEEELARLQREAAAATQKRQELEAELAKVRAEMEVLLASKARAEE 1762

Query: 153  EAAAAPEAETERVEGEEEDKEETQRDGAESKERDGEGRPAKSQEEGKRLYGRDEFEDLEW 212
            E+ +  E   +R+E E     E   + A         R     EE KR          + 
Sbjct: 1763 ESRSTSEKSKQRLEAEAGRFRELAEEAA---------RLRALAEEAKR--------QRQL 1805

Query: 213  SEEVQKLQEQQLRSDLLDQYRSLLVERNRSQRYNLYLQHKIFEALRRKKGLEAAEVADRG 272
            +EE    Q  +    L ++  ++           + L+ K  E  R ++  E      R 
Sbjct: 1806 AEEDAARQRAEAERVLAEKLAAIGEATRLKTEAEIALKEKEAENERLRRLAEDEAFQRRR 1865

Query: 273  AEAEAPEKEQAYLRHLGMLEELKKQQADDLQWYHQELGQLKRQCQEKLTRVEKEWRRFQA 332
             E +A + +      L  L +    + +  +   ++  + +RQ +E++  ++  + +  A
Sbjct: 1866 LEEQAAQHKADIEERLAQLRKASDSELERQKGLVEDTLRQRRQVEEEILALKASFEKAAA 1925

Query: 333  LKKQVVMQAMGSCRMRGGRQAALREVEQIQALEDKKEKEMSAVRLENIQLKQSLVHFETR 392
             K ++ ++ +G  R+R   +  LR  EQ + LE  ++++++A      +  +  V     
Sbjct: 1926 GKAELELE-LG--RIRSNAEDTLRSKEQAE-LEAARQRQLAAEEERRRREAEERVQKSLA 1981

Query: 393  MRTQEDLTQGLLLIDFEQLKIENQTFNEKIEERNEELLKLRSKVTNSVQVITHVKEKLHF 452
               +    +   L + E+LK + +      E   +E  +       + Q     +EK H 
Sbjct: 1982 AEEEAARQRKAALEEVERLKAKVEEARRLRERAEQESARQLQLAQEAAQKRLQAEEKAHA 2041

Query: 453  MDMENACKKTQLAEIEAQAAL 473
              ++   ++ Q    + Q+ L
Sbjct: 2042 FAVQQKEQELQQTLQQEQSVL 2062



 Score = 32.3 bits (72), Expect = 1.2
 Identities = 27/102 (26%), Positives = 54/102 (52%), Gaps = 9/102 (8%)

Query: 141  QASLPLTRIDEEEAAAAPEAETERVEGEEEDKEETQR-----DGAESKERDGEGRPAKSQ 195
            Q    L ++ ++E A A +   E+   +++ ++E QR     + A  ++ + E    + Q
Sbjct: 2497 QEKAKLEQLFQDEVAKAQQLREEQQRQQQQMEQERQRLVASMEEARRRQHEAEEGVRRKQ 2556

Query: 196  EEGKRLYGRDEFEDLEWSEEVQKLQEQ-QLRSDLLDQYRSLL 236
            EE ++L  +   ++   +EE Q+L+EQ QL   L +Q+R+ L
Sbjct: 2557 EELQQLEQQRRQQEELLAEENQRLREQLQL---LEEQHRAAL 2595


>gi|47607492 plectin 1 isoform 1 [Homo sapiens]
          Length = 4574

 Score = 75.1 bits (183), Expect = 2e-13
 Identities = 121/511 (23%), Positives = 206/511 (40%), Gaps = 85/511 (16%)

Query: 50   EEEEQAASQGGTAADEQAEAPKGLTAAEAAGEE----GPGEPGRPAEPQPEPEEPAEVGA 105
            EEEE+ A Q      ++AE  + L   EAA E+            A+ + E +E  +   
Sbjct: 1372 EEEERLAEQ------QRAEERERLAEVEAALEKQRQLAEAHAQAKAQAEREAKELQQRMQ 1425

Query: 106  EEPAQPEPGAGPEELEAEAGAEELEQAAEGKEVRFQASLPLTRIDEEEAAAAPEAETERV 165
            EE  + E  A   + +  +  EEL+Q  +  E   QA          +A  A  AE  R+
Sbjct: 1426 EEVVRREEAAVDAQQQKRSIQEELQQLRQSSEAEIQA----------KARQAEAAERSRL 1475

Query: 166  EGEEE--------DKEETQRDGAE-------SKERDGEGRPAKSQEEGKRL--YGRDEFE 208
              EEE        +  E QR GAE       ++  + E +  ++QEE +RL    +DE +
Sbjct: 1476 RIEEEIRVVRLQLEATERQRGGAEGELQALRARAEEAEAQKRQAQEEAERLRRQVQDESQ 1535

Query: 209  DLEWSE---------EVQKLQEQQLRSDLLDQYRSLLVERNRSQRYNLYLQHKIFEALRR 259
                +E         E +  +E+Q     L++ R    E  R  R          E  R 
Sbjct: 1536 RKRQAEVELASRVKAEAEAAREKQRALQALEELRLQAEEAERRLRQ--------AEVERA 1587

Query: 260  KKGLEAAEVADRGAEAEAPEKEQAYLRHLGMLEELKKQQADDLQWYHQELGQLKRQCQEK 319
            ++   A E A R AEAE   K  ++      LE         LQ  H  + QL+ + + +
Sbjct: 1588 RQVQVALETAQRSAEAELQSKRASFAEKTAQLER-------SLQEEHVAVAQLREEAERR 1640

Query: 320  L-TRVEKEWRRFQALKK----QVVMQAMGSCRMRGGRQAALREVEQIQALEDKKEKEMSA 374
               + E E  R +A ++    Q+        R++    A  + + Q +A + K+E E  A
Sbjct: 1641 AQQQAEAERAREEAERELERWQLKANEALRLRLQAEEVAQQKSLAQAEAEKQKEEAEREA 1700

Query: 375  VRLENIQLKQSLVHFETRMRTQEDLTQGLLLIDFEQLKIENQTFNEKIEERNEELLKLRS 434
             R    +        E  +R +E   Q L     +Q ++   T  +++    +EL++LR+
Sbjct: 1701 RRRGKAE--------EQAVRQRELAEQEL----EKQRQLAEGTAQQRL-AAEQELIRLRA 1747

Query: 435  KVTNSVQVITHVKEKLHFMDMENACKKTQLAEIEAQAALGRD----ILTKTKQAREGLRT 490
            +     Q    ++E+L  +  E A    +  E+EA+ A  R     +L    +A E  R+
Sbjct: 1748 ETEQGEQQRQLLEEELARLQREAAAATQKRQELEAELAKVRAEMEVLLASKARAEEESRS 1807

Query: 491  DNIRLNQKCGLLGKDSLLRDLEEKVDKTELL 521
             + +  Q+  L  +    R+L E+  +   L
Sbjct: 1808 TSEKSKQR--LEAEAGRFRELAEEAARLRAL 1836



 Score = 62.8 bits (151), Expect = 8e-10
 Identities = 99/447 (22%), Positives = 172/447 (38%), Gaps = 70/447 (15%)

Query: 119  ELEA----EAGAEELEQAAEGKEVRFQASLPLTRIDEEEAAAAPEAETERVEGEEEDKEE 174
            ELEA    +  AEE  +  E +E R Q SL      EEEAA   +A  E VE  +   EE
Sbjct: 1993 ELEAARQRQLAAEEERRRREAEE-RVQKSLAA----EEEAARQRKAALEEVERLKAKVEE 2047

Query: 175  TQRDGAESKERDGEGRPAKSQEEGKRLYGRDEFEDLEWSEEVQKLQEQ-QLRSDLLDQYR 233
             +R    +++          +   KRL   ++       ++ Q+LQ+  Q    +LDQ R
Sbjct: 2048 ARRLRERAEQESARQLQLAQEAAQKRLQAEEKAHAFAVQQKEQELQQTLQQEQSVLDQLR 2107

Query: 234  SLLVERNRSQRYNLYLQHKIFEALRRKKGLEAAEVADRGAEAEAPEKEQAYLRHLGMLEE 293
                                 EA   ++  E AE A   AE EA +  +           
Sbjct: 2108 G--------------------EAEAARRAAEEAEEARVQAEREAAQSRR----------- 2136

Query: 294  LKKQQADDLQWYHQELGQLKRQCQEKLTRVEKEWRRFQALKKQVVMQAMGSCRMRGGRQA 353
             + ++A+ L+   +E  Q + Q Q    ++ KE  +  A + Q               QA
Sbjct: 2137 -QVEEAERLKQSAEEQAQARAQAQAAAEKLRKEAEQEAARRAQ-------------AEQA 2182

Query: 354  ALREVEQIQALEDKKEKEMSAVRLENIQLKQSLVHFETRMRTQEDLTQGLLLIDFEQLK- 412
            ALR+ +   A  +K +K       +  Q++Q L     ++  + D  + LL  + ++LK 
Sbjct: 2183 ALRQKQAADAEMEKHKKFAEQTLRQKAQVEQELTTLRLQLE-ETDHQKNLLDEELQRLKA 2241

Query: 413  -----------IENQTFNEKIEERNEELLKLRSKVTNSVQVITHVKEKLHFMDMENACKK 461
                       +E + F+ +++      LK R +  N   ++        F+  E A K 
Sbjct: 2242 EATEAARQRSQVEEELFSVRVQMEELSKLKARIEAENRALILRDKDNTQRFL-QEEAEKM 2300

Query: 462  TQLAEIEAQAALGRDILTKTKQAREGLRTDNIRLNQKCGLLGKDSLLRDLEEKVDKTELL 521
             Q+AE  A+ ++      + +Q  E        L +K  L  K   +++      + ELL
Sbjct: 2301 KQVAEEAARLSVAAQEAARLRQLAEEDLAQQRALAEKM-LKEKMQAVQEATRLKAEAELL 2359

Query: 522  HRRLESLKRHHASLTLSCRGVRQKIRE 548
             ++ E  +     L      + Q++ E
Sbjct: 2360 QQQKELAQEQARRLQEDKEQMAQQLAE 2386



 Score = 62.8 bits (151), Expect = 8e-10
 Identities = 114/528 (21%), Positives = 218/528 (41%), Gaps = 53/528 (10%)

Query: 43   LESEPEEEEEEQAASQGGTAADEQAEAPKGLTAAEAAGEEGPGEPG----RPAEPQPEPE 98
            L+ E    ++ +  ++    A E+AE  +     EAA      E      + AE Q +  
Sbjct: 2096 LQQEQSVLDQLRGEAEAARRAAEEAEEARVQAEREAAQSRRQVEEAERLKQSAEEQAQAR 2155

Query: 99   EPAEVGAEEPAQPEPGAGPEELEAEAGAEELEQAAEGKEVRFQASLPLTRIDEEEAAAAP 158
              A+  AE+  +          +AE  A   +QAA+ +  + +     T    ++A    
Sbjct: 2156 AQAQAAAEKLRKEAEQEAARRAQAEQAALRQKQAADAEMEKHKKFAEQTL--RQKAQVEQ 2213

Query: 159  EAETERVEGEEEDKEETQRDGAESKERDGEGRPAKSQEEGKRLYGRDEFEDLEWSEEVQK 218
            E  T R++ EE D ++   D  E +    E   A  Q        R + E+  +S  VQ 
Sbjct: 2214 ELTTLRLQLEETDHQKNLLD-EELQRLKAEATEAARQ--------RSQVEEELFSVRVQM 2264

Query: 219  LQEQQLRSDLLDQYRSLLV-ERNRSQRYNLYLQHKIFEALRRKKGLEAAEVADRGAEAEA 277
             +  +L++ +  + R+L++ +++ +QR   +LQ    EA + K      +VA+  A    
Sbjct: 2265 EELSKLKARIEAENRALILRDKDNTQR---FLQE---EAEKMK------QVAEEAARLSV 2312

Query: 278  PEKEQAYLRHLGMLEELKKQQA------DDLQWYHQELGQLKRQC---QEKLTRVEKEWR 328
              +E A LR L   E+L +Q+A       +     QE  +LK +    Q++    +++ R
Sbjct: 2313 AAQEAARLRQLAE-EDLAQQRALAEKMLKEKMQAVQEATRLKAEAELLQQQKELAQEQAR 2371

Query: 329  RFQALKKQVVMQAMGSCRMRGGRQAALREVEQIQALEDKKEKEMSAVRLENIQLKQSLVH 388
            R Q  K+Q+  Q     +   G Q  L E E+ + LE   E E   +R+  +   Q+   
Sbjct: 2372 RLQEDKEQMAQQLAEETQ---GFQRTL-EAERQRQLEMSAEAERLKLRVAEMSRAQARAE 2427

Query: 389  FETRMRTQEDLTQGLLLIDFEQLKIENQTFNEKIEERNEELLKLRSKVTNSVQVITHVKE 448
             + +   ++    G  L   E    E  T  + +E + ++      ++  ++  +   KE
Sbjct: 2428 EDAQRFRKQAEEIGEKLHRTELATQEKVTLVQTLEIQRQQSDHDAERLREAIAELEREKE 2487

Query: 449  KLHFMDMENACKKTQLAEIEAQAALGRDILTKTKQAREGLRTDNIRLNQKCGLL--GKDS 506
            KL     +   K  QL   E Q      +L +T+  ++   ++   L Q+   +   K  
Sbjct: 2488 KL-----QQEAKLLQLKSEEMQTVQQEQLLQETQALQQSFLSEKDSLLQRERFIEQEKAK 2542

Query: 507  LLRDLEEKVDKTELL----HRRLESLKRHHASLTLSCRGVRQKIREAK 550
            L +  +++V K + L     R+ + +++    L  S    R++  EA+
Sbjct: 2543 LEQLFQDEVAKAQQLREEQQRQQQQMEQERQRLVASMEEARRRQHEAE 2590



 Score = 57.8 bits (138), Expect = 3e-08
 Identities = 120/542 (22%), Positives = 227/542 (41%), Gaps = 76/542 (14%)

Query: 43   LESEPEEEEEEQAASQGGTAADEQAEAPKGLTAAEAAGEEGPGEPG-RPAEPQPEPEEPA 101
            L+ EP  E  ++ A Q    A+ +    KG+    A  E+    P   PA P    E   
Sbjct: 1038 LDKEPARECAQRIAEQQKAQAEVEGLG-KGVARLSAEAEKVLALPEPSPAAPTLRSELEL 1096

Query: 102  EVGAEEPAQPEPGAGPEELEAEA-------GAEELEQAAEGKEVRFQASLPLTRIDEEEA 154
             +G  E  +       E+L+  +       GAEE+ +A E ++++   ++P T  + E  
Sbjct: 1097 TLGKLEQVRSLSAIYLEKLKTISLVIRGTQGAEEVLRAHE-EQLKEAQAVPATLPELE-- 1153

Query: 155  AAAPEAETERVEGEEEDKEETQRDGAESKERDGEGRPAKSQEEGKRLYGRDEFEDLE--- 211
              A +A  +++  + E ++ T  D    + R        +QE G+RL  R    D+E   
Sbjct: 1154 --ATKASLKKLRAQAEAQQPTF-DALRDELRG-------AQEVGERLQQRHGERDVEVER 1203

Query: 212  WSEEVQKLQEQ--------QLRSDLLDQY-RSLLVERNRSQRYNLYLQHKIFEALRRKKG 262
            W E V +L E+         +R   L+Q  R L   R  +     +LQ    +A RR++ 
Sbjct: 1204 WRERVAQLLERWQAVLAQTDVRQRELEQLGRQLRYYRESADPLGAWLQ----DARRRQEQ 1259

Query: 263  LEAAEVADRGAEAEAPEKEQAYL----RHLGMLEELK---KQQADDLQWYHQELGQLKRQ 315
            ++A  +AD  A  E   +EQA L    RH   +EE +   KQ  + ++ Y  +L   K Q
Sbjct: 1260 IQAMPLADSQAVREQLRQEQALLEEIERHGEKVEECQRFAKQYINAIKDYELQLVTYKAQ 1319

Query: 316  CQEKLTRVEKEWRRFQALKKQVVMQAMGSCRMRGGRQAAL--REVEQIQALEDKKEKEMS 373
             +   +  +K   + Q+  + V+ + +   R        L  + ++ I     + E+E  
Sbjct: 1320 LEPVASPAKKP--KVQSGSESVIQEYV-DLRTHYSELTTLTSQYIKFISETLRRMEEEER 1376

Query: 374  AVRLENIQLKQSLVHFETRMRTQEDLTQGLLLIDFEQLKIENQTFNEKIEER-NEELLKL 432
                +  + ++ L   E  +  Q  L +        Q K + +   +++++R  EE+++ 
Sbjct: 1377 LAEQQRAEERERLAEVEAALEKQRQLAEA-----HAQAKAQAEREAKELQQRMQEEVVRR 1431

Query: 433  RSKVTNSVQVITHVKEKLHFMDMENACKKTQLAEIEAQAALGRDILTKTKQAREGLRTDN 492
                 ++ Q    ++E+L  +      +++  AEI+A+A           +  E +R   
Sbjct: 1432 EEAAVDAQQQKRSIQEELQQL------RQSSEAEIQAKARQAEAAERSRLRIEEEIRVVR 1485

Query: 493  IRL----NQKCGLLGKDSLLRDLEEKV--------DKTELLHRRL--ESLKRHHASLTLS 538
            ++L     Q+ G  G+   LR   E+         ++ E L R++  ES ++  A + L+
Sbjct: 1486 LQLEATERQRGGAEGELQALRARAEEAEAQKRQAQEEAERLRRQVQDESQRKRQAEVELA 1545

Query: 539  CR 540
             R
Sbjct: 1546 SR 1547



 Score = 45.8 bits (107), Expect = 1e-04
 Identities = 86/441 (19%), Positives = 169/441 (38%), Gaps = 32/441 (7%)

Query: 42   ELESEPEEEEEEQAASQGGTAADEQAEAPKGLTAAEAAGEEGPGEPGRPAEPQPEPEEPA 101
            + E+E ++EE E+ A + G A +EQA   + L   E   +    E G   +     +E  
Sbjct: 1686 QAEAEKQKEEAEREARRRGKA-EEQAVRQRELAEQELEKQRQLAE-GTAQQRLAAEQELI 1743

Query: 102  EVGAE-EPAQPEPGAGPEEL---EAEAGA-----EELEQAAEGKEVRFQASLPLTRIDEE 152
             + AE E  + +     EEL   + EA A     +ELE          +  L      EE
Sbjct: 1744 RLRAETEQGEQQRQLLEEELARLQREAAAATQKRQELEAELAKVRAEMEVLLASKARAEE 1803

Query: 153  EAAAAPEAETERVEGEEEDKEETQRDGAESKERDGEGRPAKSQEEGKRLYGRDEFEDLEW 212
            E+ +  E   +R+E E     E   + A         R     EE KR          + 
Sbjct: 1804 ESRSTSEKSKQRLEAEAGRFRELAEEAA---------RLRALAEEAKR--------QRQL 1846

Query: 213  SEEVQKLQEQQLRSDLLDQYRSLLVERNRSQRYNLYLQHKIFEALRRKKGLEAAEVADRG 272
            +EE    Q  +    L ++  ++           + L+ K  E  R ++  E      R 
Sbjct: 1847 AEEDAARQRAEAERVLAEKLAAIGEATRLKTEAEIALKEKEAENERLRRLAEDEAFQRRR 1906

Query: 273  AEAEAPEKEQAYLRHLGMLEELKKQQADDLQWYHQELGQLKRQCQEKLTRVEKEWRRFQA 332
             E +A + +      L  L +    + +  +   ++  + +RQ +E++  ++  + +  A
Sbjct: 1907 LEEQAAQHKADIEERLAQLRKASDSELERQKGLVEDTLRQRRQVEEEILALKASFEKAAA 1966

Query: 333  LKKQVVMQAMGSCRMRGGRQAALREVEQIQALEDKKEKEMSAVRLENIQLKQSLVHFETR 392
             K ++ ++ +G  R+R   +  LR  EQ + LE  ++++++A      +  +  V     
Sbjct: 1967 GKAELELE-LG--RIRSNAEDTLRSKEQAE-LEAARQRQLAAEEERRRREAEERVQKSLA 2022

Query: 393  MRTQEDLTQGLLLIDFEQLKIENQTFNEKIEERNEELLKLRSKVTNSVQVITHVKEKLHF 452
               +    +   L + E+LK + +      E   +E  +       + Q     +EK H 
Sbjct: 2023 AEEEAARQRKAALEEVERLKAKVEEARRLRERAEQESARQLQLAQEAAQKRLQAEEKAHA 2082

Query: 453  MDMENACKKTQLAEIEAQAAL 473
              ++   ++ Q    + Q+ L
Sbjct: 2083 FAVQQKEQELQQTLQQEQSVL 2103



 Score = 32.3 bits (72), Expect = 1.2
 Identities = 27/102 (26%), Positives = 54/102 (52%), Gaps = 9/102 (8%)

Query: 141  QASLPLTRIDEEEAAAAPEAETERVEGEEEDKEETQR-----DGAESKERDGEGRPAKSQ 195
            Q    L ++ ++E A A +   E+   +++ ++E QR     + A  ++ + E    + Q
Sbjct: 2538 QEKAKLEQLFQDEVAKAQQLREEQQRQQQQMEQERQRLVASMEEARRRQHEAEEGVRRKQ 2597

Query: 196  EEGKRLYGRDEFEDLEWSEEVQKLQEQ-QLRSDLLDQYRSLL 236
            EE ++L  +   ++   +EE Q+L+EQ QL   L +Q+R+ L
Sbjct: 2598 EELQQLEQQRRQQEELLAEENQRLREQLQL---LEEQHRAAL 2636


>gi|214830928 coiled-coil domain containing 113 isoform 2 [Homo
           sapiens]
          Length = 323

 Score = 74.7 bits (182), Expect = 2e-13
 Identities = 67/254 (26%), Positives = 121/254 (47%), Gaps = 29/254 (11%)

Query: 291 LEELKKQQADDLQWYHQELGQLKRQCQEKLTRVEKEWRRFQALKKQVVMQAMGSCRMRGG 350
           L E+K   AD  Q   +E        + + + V +E   F+    + +++A+   + +G 
Sbjct: 64  LSEIKISAADYAQAIIEE-------AEIRWSEVSREVHEFE----KDILKAIS--KKKGS 110

Query: 351 RQAALREVEQIQALEDKKEKEMSAVRLENIQLKQSLVHFETRMRTQEDLTQGLLLIDFEQ 410
             A  + ++ I+ +  +++     +RL+N+ LK        ++R +E++++ L  +DF+Q
Sbjct: 111 ILATQKVMKYIEDMNRRRDNMKEKLRLKNVSLKVQRKKMLLQLRQKEEVSEALHDVDFQQ 170

Query: 411 LKIENQTFNEKIEERNEELLKLRSKVTNSVQVITHVKEKLH-------FMDMENACKKTQ 463
           LKIEN  F E IE RN+EL +L+    N++QV+   K KLH        +D E   +K  
Sbjct: 171 LKIENAQFLETIEARNQELTQLKLSSGNTLQVLNAYKSKLHKAMEIYLNLDKEILLRKEL 230

Query: 464 LAEIEAQAALGRDILTKTKQAREGLRTD--NIRLNQKCGLLGKDSLLRDLEEKVDKTELL 521
           L +IE +     +   K +   + LR      R  Q    + +  L  DLE+ +    + 
Sbjct: 231 LEKIEKETLQVEEDRAKAEAVNKRLRKQLAEFRAPQVMTYVREKILNADLEKSI---RMW 287

Query: 522 HRRLE----SLKRH 531
            R++E    SLK H
Sbjct: 288 ERKVEIAEMSLKGH 301


>gi|117414137 retinitis pigmentosa 1-like 1 [Homo sapiens]
          Length = 2400

 Score = 74.3 bits (181), Expect = 3e-13
 Identities = 80/301 (26%), Positives = 121/301 (40%), Gaps = 27/301 (8%)

Query: 3    VSSEHTKDPGGEGGDGESLAARPSKIKASSGPPTS---PEPGELESEPEEEE-------- 51
            + +E   +P  EG + +       + +  + P +     +  E E++PE E+        
Sbjct: 1925 LETEGEDEPESEGAEAQEAEEAAQEAEGQTQPESEVIESQEAEEEAQPESEDVEALEVEV 1984

Query: 52   EEQAASQGGTAADEQAEAPKGLTAAEAAGEEG-PGEPGRPAEPQPEPEEPAEVGAEEP-- 108
            E Q A        E  EAP+     + A EE  P   G  A+P+ E EE  EV  E    
Sbjct: 1985 ETQEAEGEAQPESEDVEAPEAEGEMQEAEEEAQPESDGVEAQPKSEGEEAQEVEGETQKT 2044

Query: 109  ---AQPEPGAGPEELEAEAGAEELEQAAEGKEVRFQASLPLTRIDEEEAAAAPEAETERV 165
               AQPE   G E  EAE  A+E E   E +E   +A      +D +EA    + E+E V
Sbjct: 2045 EGDAQPESD-GVEAPEAEEEAQEAE--GEVQEAEGEAHPESEDVDAQEAEGEAQPESEGV 2101

Query: 166  EGEEEDKEETQRDGAESKERDGEGRPAKSQEEGKRLYGRDEFEDLEWSEEVQKLQEQQLR 225
            E  E + E  + +G E+ E +GE +P     E     G  + E  E  E      E Q  
Sbjct: 2102 EAPEAEGEAQKAEGIEAPETEGEAQPESEGIEAPEAEGEAQPES-EGVEAQDAEGEAQPE 2160

Query: 226  SDLLDQYRSLLVERNRSQRYNLYLQHKIFEALRRKKGLEAAEVADRGAE----AEAPEKE 281
            S+ ++   +   E  + +   +       EA    +G+EA E            EAPE E
Sbjct: 2161 SEGIEAQEA--EEEAQPELEGVEAPEAEGEAQPESEGIEAPEAEGEAQPELEGVEAPEAE 2218

Query: 282  Q 282
            +
Sbjct: 2219 E 2219



 Score = 68.6 bits (166), Expect = 1e-11
 Identities = 80/283 (28%), Positives = 127/283 (44%), Gaps = 17/283 (6%)

Query: 12   GGEGGDGESLAARPSKIKASSGPPTSPEPGELESEPEEEEEEQAASQGGTAADEQAEAPK 71
            GG+   G+S  A   +   + G    PE   +E+ PE E + Q A        E  EAP+
Sbjct: 1821 GGDQDPGQSDGAEGIEAPEAEGE-AQPESEGVEA-PEAEGDAQEAEGEAQPESEDVEAPE 1878

Query: 72   GLTAAEAAGEEGPGEPGRPAEPQPEPEEPAEVGAEEPAQPEPGA-------GPEELEAE- 123
                A+   E+    P    E QPE E      AE+ AQPE  +       G +E E+E 
Sbjct: 1879 AEGEAQPESEDVE-TPEAEWEVQPESEGAEAPEAEKEAQPETESVEALETEGEDEPESEG 1937

Query: 124  AGAEELEQAAEGKEVRFQASLPLTRIDEEEAAAAPEAE-TERVEGEEEDKE---ETQRDG 179
            A A+E E+AA+  E + Q    +    E E  A PE+E  E +E E E +E   E Q + 
Sbjct: 1938 AEAQEAEEAAQEAEGQTQPESEVIESQEAEEEAQPESEDVEALEVEVETQEAEGEAQPES 1997

Query: 180  AESKERDGEGRPAKSQEEGKRLYGRDEFEDLEWSEEVQKLQEQQLRSDLLDQYRSLLVER 239
             + +  + EG   +++EE +      E +     EE Q+++ +  +++   Q  S  VE 
Sbjct: 1998 EDVEAPEAEGEMQEAEEEAQPESDGVEAQPKSEGEEAQEVEGETQKTEGDAQPESDGVEA 2057

Query: 240  NRSQRYNLYLQHKIFEALRRKKGLEAAEVADRGAEAEA-PEKE 281
              ++      + ++ EA   +   E+ +V  + AE EA PE E
Sbjct: 2058 PEAEEEAQEAEGEVQEA-EGEAHPESEDVDAQEAEGEAQPESE 2099



 Score = 65.5 bits (158), Expect = 1e-10
 Identities = 61/211 (28%), Positives = 89/211 (42%), Gaps = 18/211 (8%)

Query: 2    DVSSEHTKDPGGEGGDGESLAARPSKIKASSGPPTSPEPGELESEPEEEEEEQAASQGGT 61
            +V  E  K  G    + + + A  ++ +A        E  E E+ PE E+ +   ++G  
Sbjct: 2036 EVEGETQKTEGDAQPESDGVEAPEAEEEAQEAEGEVQE-AEGEAHPESEDVDAQEAEGEA 2094

Query: 62   AAD-EQAEAP---------KGLTAAEAAGE-----EGPGEPGRPAEPQPEPEEPAEVGAE 106
              + E  EAP         +G+ A E  GE     EG   P    E QPE E      AE
Sbjct: 2095 QPESEGVEAPEAEGEAQKAEGIEAPETEGEAQPESEGIEAPEAEGEAQPESEGVEAQDAE 2154

Query: 107  EPAQPEPGAGPEELEAEAGAEELEQAAEGKEVRFQASLPLTRIDEEEAAAAPEAETERVE 166
              AQPE   G E  EAE  A+   +  E  E   +A      I+  EA    + E E VE
Sbjct: 2155 GEAQPE-SEGIEAQEAEEEAQPELEGVEAPEAEGEAQPESEGIEAPEAEGEAQPELEGVE 2213

Query: 167  G-EEEDKEETQRDGAESKERDGEGRPAKSQE 196
              E E++ + + +G E+ E +GE +P    E
Sbjct: 2214 APEAEEEAQPEPEGVETPEAEGEAQPESEGE 2244



 Score = 62.8 bits (151), Expect = 8e-10
 Identities = 58/181 (32%), Positives = 78/181 (43%), Gaps = 24/181 (13%)

Query: 39   EPGELESEPEEEEEEQAASQGGTAADEQAEAPK----------GLTAAEAAGEEGPGEPG 88
            +  E E++PE E  E   ++G     E  EAP+          G+ A EA GE  P   G
Sbjct: 2088 QEAEGEAQPESEGVEAPEAEGEAQKAEGIEAPETEGEAQPESEGIEAPEAEGEAQPESEG 2147

Query: 89   RPA-----EPQPEPEEPAEVGAEEPAQPEPGAGPEELEAEAGAEELEQAAEGKEVRFQAS 143
              A     E QPE E      AEE AQPE   G E  EAE  A+   +  E  E   +A 
Sbjct: 2148 VEAQDAEGEAQPESEGIEAQEAEEEAQPEL-EGVEAPEAEGEAQPESEGIEAPEAEGEAQ 2206

Query: 144  LPLTRID----EEEAAAAPEA-ETERVEGEEEDKEETQRDGAESKERD---GEGRPAKSQ 195
              L  ++    EEEA   PE  ET   EGE + + E +  G +        G+G+  ++ 
Sbjct: 2207 PELEGVEAPEAEEEAQPEPEGVETPEAEGEAQPESEGETQGEKKGSPQVSLGDGQSEEAS 2266

Query: 196  E 196
            E
Sbjct: 2267 E 2267



 Score = 60.1 bits (144), Expect = 5e-09
 Identities = 81/344 (23%), Positives = 130/344 (37%), Gaps = 43/344 (12%)

Query: 12   GGEGGDGESLAARPSKIKASSGPPTS-------PEPGELESEPEEEEEE--------QAA 56
            G EGG G  L+  P   +   G  +        P+ GE E +   +E E         A 
Sbjct: 1725 GAEGGLGPGLSQGPGVDEGEDGEGSQRLNRDKDPKLGEAEGDAMAQEREGKTHNSETSAG 1784

Query: 57   SQGGTAADE-QAEAPKGLTAAEAAGEEG--PGEPGRPAEPQPEPEEPAEVGAEEP----- 108
            S+ G A  E +  + +G T  + +G E    GE     +  P   + AE G E P     
Sbjct: 1785 SELGEAEQEGEGISERGETGGQGSGHEDNLQGEAAAGGDQDPGQSDGAE-GIEAPEAEGE 1843

Query: 109  AQPEPGAGPEELEAEAGAEELEQAA-------EGKEVRFQASLPLTRIDEEEAAAAPEAE 161
            AQPE   G E  EAE  A+E E  A       E  E   +A      ++  EA    + E
Sbjct: 1844 AQPE-SEGVEAPEAEGDAQEAEGEAQPESEDVEAPEAEGEAQPESEDVETPEAEWEVQPE 1902

Query: 162  TERVEGEEEDKE-ETQRDGAESKERDGEGRPAKSQEEGKRLYGRDEFEDLEWSEEVQKLQ 220
            +E  E  E +KE + + +  E+ E +GE  P     E +      +  + +   E + ++
Sbjct: 1903 SEGAEAPEAEKEAQPETESVEALETEGEDEPESEGAEAQEAEEAAQEAEGQTQPESEVIE 1962

Query: 221  EQQLRSDLLDQYRSLLVERNRSQRYNLYLQHKIFEALRRKKGLEAAEVADRGAEAEAPEK 280
             Q+   +   +   +      +    +  Q    EA    + +EA E     AE E  E 
Sbjct: 1963 SQEAEEEAQPESEDV-----EALEVEVETQEAEGEAQPESEDVEAPE-----AEGEMQEA 2012

Query: 281  EQAYLRHLGMLEELKKQQADDLQWYHQELGQLKRQCQEKLTRVE 324
            E+        +E   K + ++ Q    E  + +   Q +   VE
Sbjct: 2013 EEEAQPESDGVEAQPKSEGEEAQEVEGETQKTEGDAQPESDGVE 2056



 Score = 40.4 bits (93), Expect = 0.004
 Identities = 34/123 (27%), Positives = 49/123 (39%), Gaps = 1/123 (0%)

Query: 12   GGEGGDGESLAARPSK-IKASSGPPTSPEPGELESEPEEEEEEQAASQGGTAADEQAEAP 70
            G E  D E  A   S+ I+A      +    E    PE E E Q  S+G  A + + EA 
Sbjct: 2147 GVEAQDAEGEAQPESEGIEAQEAEEEAQPELEGVEAPEAEGEAQPESEGIEAPEAEGEAQ 2206

Query: 71   KGLTAAEAAGEEGPGEPGRPAEPQPEPEEPAEVGAEEPAQPEPGAGPEELEAEAGAEELE 130
              L   EA   E   +P       PE E  A+  +E   Q E    P+    +  +EE  
Sbjct: 2207 PELEGVEAPEAEEEAQPEPEGVETPEAEGEAQPESEGETQGEKKGSPQVSLGDGQSEEAS 2266

Query: 131  QAA 133
            +++
Sbjct: 2267 ESS 2269



 Score = 40.0 bits (92), Expect = 0.006
 Identities = 60/231 (25%), Positives = 95/231 (41%), Gaps = 38/231 (16%)

Query: 4    SSEHTKDPGGEGGDGESLAARPSKIKASSGPPTSPEPGELESEPEEEEEEQAASQGGTAA 63
            SS       G GG GES    P  +  +     +  P  L++  +  +     S G    
Sbjct: 1197 SSSGVDISSGSGGSGESSV--PCAMDGTLVTQGTELP--LKTSNQRPDSRTYESPGDLEN 1252

Query: 64   DEQAEAPKGLTAAEAAGEEGPGEPGRPAEPQPEPEEPAEVGAEEPAQPEPGAGPEELEAE 123
             +Q   P  L A   A      E  R +E     E+ A    E+ A+         ++ E
Sbjct: 1253 QQQCCFPTFLNARACACATNEDEAERDSE-----EQRASSNLEQLAE-------NTVQEE 1300

Query: 124  AGAEELEQAAEGKEVRFQA-SLPLTRIDE--EEAAAAPEAETERVEGEEEDKEETQRDGA 180
               EE ++  EG+ ++ +A  L  T+ +E  +E     E ET+  EGE + +EE Q +  
Sbjct: 1301 VQLEETKEGTEGEGLQEEAVQLEETKTEEGLQEEGVQLE-ETKETEGEGQQEEEAQLE-- 1357

Query: 181  ESKERDGEGRPAKSQEEGKRLYGRDEFEDLEWSEEVQKLQEQQLRSDLLDQ 231
            E +E  GEG     QEEG +L            EEV++  E  L+ + L++
Sbjct: 1358 EIEETGGEG----LQEEGVQL------------EEVKEGPEGGLQGEALEE 1392



 Score = 39.7 bits (91), Expect = 0.007
 Identities = 45/157 (28%), Positives = 67/157 (42%), Gaps = 21/157 (13%)

Query: 3    VSSEHT-KDPGGEGGDGESLAARPSKIKASSGPPTSPEPGELESEPEEE--------EEE 53
            +S E T +  GG  G  E+    PS +  SS  P +     L++ PEE         +E 
Sbjct: 922  LSEEKTLRSGGGPQGQEEASGVSPSSLPRSS--PEAVVREWLDNIPEEPILMTYELADET 979

Query: 54   QAASQGGTAADE----QAEAPKGLTAAEAAGEEG-PGEPGRPAEPQPEPEEPAEVGAEEP 108
              A+ GG    E       + +GL     AG++   G+PG+  EP+      ++ G +  
Sbjct: 980  TGAAGGGLRGPEVDPGDDHSLEGLGEPAQAGQQSLEGDPGQDPEPEGALLGSSDTGPQSG 1039

Query: 109  AQPEPGAGPE---ELEAEAGAEELEQAAEGKEVRFQA 142
                 GA PE   E  AEAGA+   +A  G  V  +A
Sbjct: 1040 EGVPQGAAPEGVSEAPAEAGAD--REAPAGCRVSLRA 1074



 Score = 38.5 bits (88), Expect = 0.016
 Identities = 39/157 (24%), Positives = 61/157 (38%), Gaps = 15/157 (9%)

Query: 38   PEPGELESEPEEEEEEQAASQGGTAADEQAEAPKGLTAAEAAGEEGPGEPGRPAEPQPEP 97
            PEP  +E+ PE E E Q  S+G T  +++      L   ++   E   E   P  P+  P
Sbjct: 2223 PEPEGVET-PEAEGEAQPESEGETQGEKKGSPQVSLGDGQS---EEASESSSPV-PEDRP 2277

Query: 98   EEPAEVGAEEPAQ-PEPGAGPEELEAEAGAEELEQAAEGKEVRFQASLPLTRIDEEEAAA 156
              P   G + P Q P    GP    A +     ++ +E   V     L  TR  + ++  
Sbjct: 2278 TPPPSPGGDTPHQRPGSQTGPSSSRASSWGNCWQKDSENDHV-----LGDTRSPDAKSTG 2332

Query: 157  APEAETERV----EGEEEDKEETQRDGAESKERDGEG 189
             P AE +      E    ++EE        ++   EG
Sbjct: 2333 TPHAERKATRMYPESSTSEQEEAPLGSRTPEQGASEG 2369



 Score = 34.7 bits (78), Expect = 0.24
 Identities = 43/155 (27%), Positives = 59/155 (38%), Gaps = 28/155 (18%)

Query: 3    VSSEHTKDPGGEGGDGESLAARPSKIKASSGPPTSPEPGELESEPEEEE----------- 51
            V  E TK+  GEG   E   A+  +I+ + G     E  +LE   E  E           
Sbjct: 1336 VQLEETKETEGEGQQEEE--AQLEEIEETGGEGLQEEGVQLEEVKEGPEGGLQGEALEEG 1393

Query: 52   --EEQAASQGGTAADEQAEAP----KGLTAAEAAGEEGPGEPGRPAEPQP-----EP-EE 99
              EE    +G     E +EA     KG    +   EE  G     AEP P     EP E 
Sbjct: 1394 LKEEGLPEEGSVHGQELSEASSPDGKGSQEDDPVQEEEAGRASASAEPCPAEGTEEPTEP 1453

Query: 100  PAEVGAEEPAQPEPGAGPE---ELEAEAGAEELEQ 131
            P+ +   +P+  E  +G +    LE   GA  + Q
Sbjct: 1454 PSHLSETDPSASERQSGSQLEPGLEKPPGATMMGQ 1488


>gi|78190492 retinitis pigmentosa GTPase regulator isoform C [Homo
            sapiens]
          Length = 1152

 Score = 70.5 bits (171), Expect = 4e-12
 Identities = 66/214 (30%), Positives = 89/214 (41%), Gaps = 27/214 (12%)

Query: 14   EGGDGESLAARPSKIKASSGPPTSPEPGELESEPEEEEEEQAASQGGTAADEQAEAPKGL 73
            E G+GE       + +   G     E GE   E E E EE+     G   + + E  +G 
Sbjct: 898  EEGEGEGEEEGEGEGEEEEGEGKGEEEGE---EGEGEGEEEEGEGEGEDGEGEGEEEEG- 953

Query: 74   TAAEAAGEEGPGEPGRPAEPQPEPEEPAEVGAEEPAQPEPGAGPEELEAEAGAEELEQAA 133
               E  GEE  GE     E + E EE    G EE  +   G G EE   E G EE E   
Sbjct: 954  ---EWEGEEEEGEGEGEEEGEGEGEEGEGEGEEEEGE---GEGEEEEGEEEGEEEGEGEE 1007

Query: 134  EGKEVRFQASLPLTRIDEEEAAAAPEAETERVEGEEEDKEETQRDGAESKERDGEG---- 189
            EG+              EEE     E E E  EGE E +EE   +  E +E++GEG    
Sbjct: 1008 EGEGE-----------GEEEEEGEVEGEVEGEEGEGEGEEEEGEEEGEEREKEGEGEENR 1056

Query: 190  --RPAKSQEEGKRLYGRDEFEDLEWSEEVQKLQE 221
              R  + +EEGK     +E  + +  EE +K+ +
Sbjct: 1057 RNREEEEEEEGKYQETGEEENERQDGEEYKKVSK 1090



 Score = 68.2 bits (165), Expect = 2e-11
 Identities = 62/199 (31%), Positives = 86/199 (43%), Gaps = 29/199 (14%)

Query: 39   EPGELESEPEEE---EEEQAASQGGTAADEQAEAPKGLTAAEAAGEEGPGEPGRPAEPQP 95
            E GE E E E E   EEE+   +G    + + E  +G    E  GEEG GE G   E + 
Sbjct: 881  EEGEGEGEEEGEGEGEEEEGEGEGEEEGEGEGEEEEGEGKGEEEGEEGEGE-GEEEEGEG 939

Query: 96   EPEEPAEVGAEEPAQPEPGAGPEELEAEAGAEELEQAAEGKEVRFQASLPLTRIDEEEAA 155
            E E+    G EE  + E     EE E E   EE E   EG+E   +        +EEE  
Sbjct: 940  EGEDGEGEGEEEEGEWEG----EEEEGEGEGEE-EGEGEGEEGEGEG-------EEEEGE 987

Query: 156  AAPEAETERVEGEEEDKEETQRDG-------------AESKERDGEGRPAKSQEEGKRLY 202
               E E    EGEEE + E + +G              E +E +GEG   + +EEG+   
Sbjct: 988  GEGEEEEGEEEGEEEGEGEEEGEGEGEEEEEGEVEGEVEGEEGEGEGEEEEGEEEGEERE 1047

Query: 203  GRDEFEDLEWSEEVQKLQE 221
               E E+   + E ++ +E
Sbjct: 1048 KEGEGEENRRNREEEEEEE 1066



 Score = 67.0 bits (162), Expect = 4e-11
 Identities = 64/225 (28%), Positives = 89/225 (39%), Gaps = 24/225 (10%)

Query: 6   EHTKDPGGEGGDGESLAARPSKIKASSGPPTSPEPGELESEPEEEEEEQAASQGGTAADE 65
           E  +  G E G+GE +     K           E GE + E    +EE+   +G     E
Sbjct: 749 EEKEGEGKEEGEGEEVEGEREK-----------EEGERKKEERAGKEEKGEEEGDQGEGE 797

Query: 66  QAEAPKGLTAAEAAGEEGPGEPGRPAEPQPEPEEPAEVGAEE-PAQPEPGAGPEELEAEA 124
           + E        E  GE   GE       + E EE  E   EE   + E G G EE E E 
Sbjct: 798 EEETEGRGEEKEEGGEVEGGEVEEGKGEREEEEEEGEGEEEEGEGEEEEGEGEEE-EGEG 856

Query: 125 GAEELEQAAEGKEVRFQASLPLTRID-EEEAAAAPEAETERVEGEEEDKEETQRDG---- 179
             EE  +  EG+E   +        + E E     E E E  EGE E +EE + +G    
Sbjct: 857 KGEEEGEEGEGEEEGEEGEGEGEEEEGEGEGEEEGEGEGEEEEGEGEGEEEGEGEGEEEE 916

Query: 180 ------AESKERDGEGRPAKSQEEGKRLYGRDEFEDLEWSEEVQK 218
                  E +E +GEG   + + EG+   G  E E+ EW  E ++
Sbjct: 917 GEGKGEEEGEEGEGEGEEEEGEGEGEDGEGEGEEEEGEWEGEEEE 961



 Score = 66.6 bits (161), Expect = 6e-11
 Identities = 63/210 (30%), Positives = 89/210 (42%), Gaps = 6/210 (2%)

Query: 14   EGGDGESLAARPSKIKASSGPPTSPEPGELESEPEEEEEEQAASQGGTAADEQAEAPKGL 73
            E G+GE       + +         E GE E E EE E E    +G    +E+ E     
Sbjct: 838  EEGEGEEEEGEGEEEEGEGKGEEEGEEGEGEEEGEEGEGEGEEEEGEGEGEEEGEGEGEE 897

Query: 74   TAAEAAGEE-GPGEPGRPAEPQPEPEEPAEVGAEEPAQPEPGAGPEELEAEAGAEELEQA 132
               E  GEE G GE G   E + + EE  E G  E  + E     E+ E E   EE E  
Sbjct: 898  EEGEGEGEEEGEGE-GEEEEGEGKGEEEGEEGEGEGEEEEGEGEGEDGEGEGEEEEGEWE 956

Query: 133  AEGKEVRFQASLPLTRIDEEEAAAAPEAETERVEGEEEDKEETQRDGAESKERDGEGRPA 192
             E +E   +         EE      E E E    EEE +EE + +G   +E +GEG   
Sbjct: 957  GEEEEGEGEGEEEGEGEGEEGEGEGEEEEGEGEGEEEEGEEEGEEEGEGEEEGEGEG--- 1013

Query: 193  KSQEEGKRLYGRDEFEDLEWSEEVQKLQEQ 222
            + +EEG+ + G  E E+ E   E ++ +E+
Sbjct: 1014 EEEEEGE-VEGEVEGEEGEGEGEEEEGEEE 1042



 Score = 65.9 bits (159), Expect = 1e-10
 Identities = 63/214 (29%), Positives = 86/214 (40%), Gaps = 37/214 (17%)

Query: 10  DPGGEGGDGESLAARPSKIKASSGPPTSPEPGELESEPEEEEEEQAASQGGTAADEQAEA 69
           + GGE   GE                   E G+ E E E+E E +   +G     E+ + 
Sbjct: 728 EEGGEEEHGEG----------------EEEEGDREEEEEKEGEGKEEGEGEEVEGEREKE 771

Query: 70  PKGLTAAEAAGEEGPGE------PGRPAEPQPEPEEPAEVGAEEPAQPEPGAGPEELEAE 123
                  E AG+E  GE       G   E +   EE  E G  E  + E G G  E E E
Sbjct: 772 EGERKKEERAGKEEKGEEEGDQGEGEEEETEGRGEEKEEGGEVEGGEVEEGKGEREEEEE 831

Query: 124 AGAEELEQAAEGKEVRFQASLPLTRIDEEEAAAAPEAETERVEGEEE------DKEETQR 177
            G  E E+  EG+E   +        +EEE     E E E  EGEEE      + EE + 
Sbjct: 832 EGEGE-EEEGEGEEEEGEG-------EEEEGEGKGEEEGEEGEGEEEGEEGEGEGEEEEG 883

Query: 178 DGAESKERDGEGRPAKSQEEGKRLYGRDEFEDLE 211
           +G   +E +GEG   + + EG+   G  E E+ E
Sbjct: 884 EGEGEEEGEGEGEEEEGEGEGEE-EGEGEGEEEE 916



 Score = 62.8 bits (151), Expect = 8e-10
 Identities = 57/205 (27%), Positives = 84/205 (40%), Gaps = 11/205 (5%)

Query: 16  GDGESLAARPSKIKASSGPPTSPEPGEL--ESEPEEEEEEQAASQGGTAADEQAEAPKGL 73
           G+GE   A   + K   G     +  E   + E  +E EE    + G   +E+ +  +  
Sbjct: 690 GEGEKELAEKEEWKKRDGEEQEQKEREQGHQKERNQEMEEGGEEEHGEGEEEEGDREEEE 749

Query: 74  TAAEAAGEEGPGEP--GRPAEPQPEPEEPAEVGAEEPAQPEPGAGP-EELEAEAGAEELE 130
                  EEG GE   G   + + E ++    G EE  + E   G  EE E E   EE E
Sbjct: 750 EKEGEGKEEGEGEEVEGEREKEEGERKKEERAGKEEKGEEEGDQGEGEEEETEGRGEEKE 809

Query: 131 QAAEGKEVRFQASLPLTRIDEEEAAAAPEAETERVEGEEEDKEETQRDGAESKERDGEGR 190
           +  E +    +        +EEE     E E E  EGEEE+ E  + +G    E +GE  
Sbjct: 810 EGGEVEGGEVEEGKGEREEEEEEG----EGEEEEGEGEEEEGEGEEEEGEGKGEEEGE-- 863

Query: 191 PAKSQEEGKRLYGRDEFEDLEWSEE 215
             + +EEG+   G  E E+ E   E
Sbjct: 864 EGEGEEEGEEGEGEGEEEEGEGEGE 888



 Score = 59.3 bits (142), Expect = 9e-09
 Identities = 65/229 (28%), Positives = 97/229 (42%), Gaps = 27/229 (11%)

Query: 5   SEHTKDPGGEGGDGESLAARPSKIKASSGPPTSPEPGELE-SEPEE------EEEEQAAS 57
           +EH +D   E G+ +             G    P  GE E +E EE      EE+EQ   
Sbjct: 666 AEHWQDEEREKGEKDK----------GRGEMERPGEGEKELAEKEEWKKRDGEEQEQKER 715

Query: 58  QGGTAADEQAEAPKGLTAAEAAGEEGPGEPGRPAEPQPEPEEPAEVGAEEPAQPEPGAGP 117
           + G   +   E  +G       GEE  G+     E + E +E  E G E   + E   G 
Sbjct: 716 EQGHQKERNQEMEEGGEEEHGEGEEEEGDREEEEEKEGEGKEEGE-GEEVEGEREKEEGE 774

Query: 118 EELEAEAGAEELEQAAEGKEVRFQASLPLTRIDEEEAAAAPEA-ETERVEGE-EEDKEE- 174
            + E  AG EE  +  EG +   +      R +E+E     E  E E  +GE EE++EE 
Sbjct: 775 RKKEERAGKEEKGEE-EGDQGEGEEEETEGRGEEKEEGGEVEGGEVEEGKGEREEEEEEG 833

Query: 175 -TQRDGAESKERDGEGR----PAKSQEEGKRLYGRDEFEDLEWSEEVQK 218
             + +  E +E +GEG       K +EEG+   G +E E+ E   E ++
Sbjct: 834 EGEEEEGEGEEEEGEGEEEEGEGKGEEEGEEGEGEEEGEEGEGEGEEEE 882



 Score = 57.8 bits (138), Expect = 3e-08
 Identities = 59/193 (30%), Positives = 70/193 (36%), Gaps = 33/193 (17%)

Query: 13   GEGGDGESLAARPSKIKASSGPPTSPEPGELESEPEEEEEEQAASQGGTAADEQAEAPKG 72
            GEG DGE                   E  E E E EEEE E    + G    E+ E    
Sbjct: 939  GEGEDGEG----------------EGEEEEGEWEGEEEEGEGEGEEEGEGEGEEGEGEGE 982

Query: 73   LTAAEAAGEEGPGEPGRPAEPQPEPEEPAEVGAEEPAQPEPGAGPEELEAEAGAEELEQA 132
                E  GEE  GE     E + E EE  E   EE  + E     E  E E   EE E  
Sbjct: 983  EEEGEGEGEEEEGE--EEGEEEGEGEEEGEGEGEEEEEGEVEGEVEGEEGEGEGEEEEGE 1040

Query: 133  AEGKEVRFQASLPLTRIDEEEAAAAPEAETERVEGEEEDKEETQRDGAESKER-DGEGRP 191
             EG              +E E     E      E EEE++ + Q  G E  ER DGE   
Sbjct: 1041 EEG--------------EEREKEGEGEENRRNREEEEEEEGKYQETGEEENERQDGEEYK 1086

Query: 192  AKSQEEGKRLYGR 204
              S+ +G   YG+
Sbjct: 1087 KVSKIKGSVKYGK 1099



 Score = 49.7 bits (117), Expect = 7e-06
 Identities = 50/218 (22%), Positives = 77/218 (35%), Gaps = 17/218 (7%)

Query: 6   EHTKDPGGEGGDGESLAARPSKIKASSGPPTSPEPGELESEPEEEEEEQAASQGGTAADE 65
           E  +D  G G + + + A    +K   G     E    +   + E  E  A   G A D 
Sbjct: 591 EGAEDSKGNGIEEQEVEANEENVKVHGGRKEKTEILSDDLTDKAEVSEGKAKSVGEAEDG 650

Query: 66  QAEAPKGLTAAEAAGEEGPGEPGRPAEPQPEPEEPAEVGAEEPAQPEPGAGPEELEAEAG 125
                 G     ++G E           Q E  E  E          PG G +EL  +  
Sbjct: 651 PEGRGDGTCEEGSSGAE---------HWQDEEREKGEKDKGRGEMERPGEGEKELAEKEE 701

Query: 126 AEELEQAAEGKEVRFQASLPLTRIDEEEAAAAPEAETERVEGEEEDKEETQRDGAESKER 185
            ++ +   + ++ R Q        + EE       E E  EG+ E++EE + +G E  E 
Sbjct: 702 WKKRDGEEQEQKEREQGHQKERNQEMEEGGEEEHGEGEEEEGDREEEEEKEGEGKEEGEG 761

Query: 186 D--------GEGRPAKSQEEGKRLYGRDEFEDLEWSEE 215
           +         EG   K +  GK   G +E +  E  EE
Sbjct: 762 EEVEGEREKEEGERKKEERAGKEEKGEEEGDQGEGEEE 799



 Score = 48.9 bits (115), Expect = 1e-05
 Identities = 51/186 (27%), Positives = 75/186 (40%), Gaps = 13/186 (6%)

Query: 48  EEEEEEQAASQGGTAADEQAEAPKGLTAAEA----AGEEGPGEPGRPAEPQPEPEEPAEV 103
           +EE E+    +G    +   E  K L   E      GEE   +       +   +E  E 
Sbjct: 671 DEEREKGEKDKGRGEMERPGEGEKELAEKEEWKKRDGEEQEQKEREQGHQKERNQEMEEG 730

Query: 104 GAEEPAQPEPGAGPEELEAEAGAEELEQAAEGKEVRFQASLPLTRIDEEEAAAAPEAETE 163
           G EE  + E   G  E E E   E  E+  EG+EV  +         +EE A   E   E
Sbjct: 731 GEEEHGEGEEEEGDREEEEEKEGEGKEEG-EGEEVEGEREKEEGERKKEERAGKEEKGEE 789

Query: 164 RVEGEEEDKEETQRDG-AESKE-----RDGEGRPAKSQEEGKRLYGRDEFEDLEWSEEVQ 217
             EG++ + EE + +G  E KE       GE    K + E +   G  E E+ E  EE  
Sbjct: 790 --EGDQGEGEEEETEGRGEEKEEGGEVEGGEVEEGKGEREEEEEEGEGEEEEGEGEEEEG 847

Query: 218 KLQEQQ 223
           + +E++
Sbjct: 848 EGEEEE 853



 Score = 44.3 bits (103), Expect = 3e-04
 Identities = 62/263 (23%), Positives = 106/263 (40%), Gaps = 21/263 (7%)

Query: 44  ESEPEEEEEEQAASQGGTAADEQAEAPKGLTAAEAAGEEGPGEPGRPAEPQPEPEE--PA 101
           E E  EE+E    S+G    +++ EA +         +E           + E  E    
Sbjct: 583 EVEIPEEKEGAEDSKGNGIEEQEVEANEENVKVHGGRKEKTEILSDDLTDKAEVSEGKAK 642

Query: 102 EVGAEEPAQPEPGAGPEELEAEAGAEELEQAAEGKEVRFQASLPLTRIDEEEAAAAPEAE 161
            VG  E      G G  E E  +GAE  +     K  + +    + R  E E   A + E
Sbjct: 643 SVGEAEDGPEGRGDGTCE-EGSSGAEHWQDEEREKGEKDKGRGEMERPGEGEKELAEKEE 701

Query: 162 TERVEGEEEDKEETQRDGAESKERDGEGRPAKSQEEGKRLYGRDEFEDLEWSEEVQKLQE 221
            ++ +GEE++++E  R+    KER+ E      +E G+   G +E  D E  EE +   +
Sbjct: 702 WKKRDGEEQEQKE--REQGHQKERNQEMEEGGEEEHGE---GEEEEGDREEEEEKEGEGK 756

Query: 222 QQLRSDLLDQYRSLLVERNRSQRYNLYLQHKIFEALRRKKGLE---AAEVADRGAEAEAP 278
           ++   + ++  R    E+   +R       K   A + +KG E     E  +   E    
Sbjct: 757 EEGEGEEVEGER----EKEEGER------KKEERAGKEEKGEEEGDQGEGEEEETEGRGE 806

Query: 279 EKEQAYLRHLGMLEELKKQQADD 301
           EKE+      G +EE K ++ ++
Sbjct: 807 EKEEGGEVEGGEVEEGKGEREEE 829


>gi|153791497 ciliary rootlet coiled-coil [Homo sapiens]
          Length = 2017

 Score = 70.5 bits (171), Expect = 4e-12
 Identities = 126/570 (22%), Positives = 230/570 (40%), Gaps = 67/570 (11%)

Query: 32   SGPPTSPEPGELESEPEEEEEEQAASQGGTAADEQAEAPKGLTAAEAAGEEGPGEPGRPA 91
            SG     E    E++ + E  E+AA +    A E A     L AAE  G     E  R  
Sbjct: 844  SGREQELEQARREAQRQVEALERAAREKEALAKEHAGLAVQLVAAEREGRTLSEEATRLR 903

Query: 92   EPQPEPEEPAEVGAEEPAQPEPGAGPEELEAEAGA-----EELEQAAEGKEVRFQASLPL 146
              +   E        + AQ E  A  E+LEAE  A     E L     G   +  A+   
Sbjct: 904  LEKEALEGSLFEVQRQLAQLE--ARREQLEAEGQALLLAKETLTGELAGLRQQIIATQEK 961

Query: 147  TRIDEEEAA-----AAPEAET---ERVEGEEEDKEETQRDG-AESKERDGEGRPAKSQ-- 195
              +D+E  A     A  EA+    E+    EED +  QR+  A  +E + E    +SQ  
Sbjct: 962  ASLDKELMAQKLVQAEREAQASLREQRAAHEEDLQRLQREKEAAWRELEAERAQLQSQLQ 1021

Query: 196  EEGKRLYGRDEFEDLEWSEEVQKLQ------------EQQLRSDLLDQYRSLLVERNRSQ 243
             E + L  R E E  E SEE+  LQ            E+Q    L +  ++ L E+    
Sbjct: 1022 REQEELLARLEAEKEELSEEIAALQQERDEGLLLAESEKQQALSLKESEKTALSEKLMGT 1081

Query: 244  RYNLYLQHKIFEALRRKKGLEAAEVADRGAEAEAP--------EKEQAYLRHLGMLEELK 295
            R++L       E  R+K+  ++ +  DR               ++E+A   H   +  L+
Sbjct: 1082 RHSLATIS--LEMERQKRDAQSRQEQDRSTVNALTSELRDLRAQREEAAAAHAQEVRRLQ 1139

Query: 296  KQQADDLQWYHQELGQLKRQCQEKLTRVEKEWRRFQALK---KQVVMQAMGSCR-MRGGR 351
            +Q  D        LG+ +  C  +   +  + R  +  +   ++ +++A    R  + GR
Sbjct: 1140 EQARD--------LGKQRDSCLREAEELRTQLRLLEDARDGLRRELLEAQRKLRESQEGR 1191

Query: 352  QAALREVEQIQALEDKKEKEMSAVRLENIQLKQSLVHFETRMRT----QEDLTQGLLLID 407
            +   +E  +++    +  KE  A+R  N +L+ ++   E+   +     ED  Q L L++
Sbjct: 1192 EVQRQEAGELRRSLGEGAKEREALRRSNEELRSAVKKAESERISLKLANEDKEQKLALLE 1251

Query: 408  FEQLKIENQTFNEKIEERNEELLKLRSKVTNSVQVITHVKEKLHFMDMENACKKTQLAEI 467
              +  +  +    +   +  E  +L ++     + +  ++ ++  +D EN     +LAE+
Sbjct: 1252 EARTAVGKEAGELRTGLQEVERSRLEAR-----RELQELRRQMKMLDSENTRLGRELAEL 1306

Query: 468  EAQAALGRDILTKTKQAREGLRTDNIRLNQKCGLLGKDSLL--RDLEEKVDKTELLHRR- 524
            + + ALG     ++++   GLR   ++      ++ ++  +  R L+E+  +     RR 
Sbjct: 1307 QGRLALGERAEKESRRETLGLRQRLLKGEASLEVMRQELQVAQRKLQEQEGEFRTRERRL 1366

Query: 525  ---LESLKRHHASLTLSCRGVRQKIREAKA 551
               LE  +          RG+  K+  A+A
Sbjct: 1367 LGSLEEARGTEKQQLDHARGLELKLEAARA 1396



 Score = 56.2 bits (134), Expect = 8e-08
 Identities = 121/495 (24%), Positives = 193/495 (38%), Gaps = 64/495 (12%)

Query: 46   EPEEEEEEQAASQGGTAADEQAEAPKGLTAAEAAGEEGPGEPGRPAEPQPEPEEPAEVGA 105
            E  + E ++  S     + E++     L  A+   EE   E  +    Q E     +   
Sbjct: 585  EDAQREVQRLRSANELLSREKSNLAHSLQVAQQQAEELRQEREKLQAAQEELRRQRDRLE 644

Query: 106  EEPAQPEPGAGPEELEAEAGAEELEQAAEGKEVRFQASLPLTRIDEEEAAAAPEAETERV 165
            EE             E E    +LEQ  EGK    ++ L    ++  EA +    + + +
Sbjct: 645  EEQEDAVQDGARVRRELERSHRQLEQL-EGK----RSVLAKELVEVREALSRATLQRDML 699

Query: 166  EGEEED------KEETQRDGAESKERDGEGRPAKSQEEGKRLYGRDEF---EDLEWSEEV 216
            + E+ +      K E  R   E          A  Q+   +L   +E    + L+ +  V
Sbjct: 700  QAEKAEVAEALTKAEAGRVELELSMTKLRAEEASLQDSLSKLSALNESLAQDKLDLNRLV 759

Query: 217  QKLQEQQLRSDLLDQYRSLLVERNRSQRYNLYLQHKIFEALRRKKGLEAA-EVADRGAEA 275
             +L+E+  +S L  + R    E   ++     L+    E    ++GLE +  VA++  EA
Sbjct: 760  AQLEEE--KSALQGRQRQAEQEATVAREEQERLEELRLEQEVARQGLEGSLRVAEQAQEA 817

Query: 276  EAPEKEQAYLRH-LGMLEELKKQQADDLQWYHQELGQLKRQCQEKLTRVEKEWRRFQALK 334
               E++   LRH    L+E   Q +  L    QEL Q +R+ Q ++  +E+  R  +AL 
Sbjct: 818  L--EQQLPTLRHERSQLQEQLAQLSRQLSGREQELEQARREAQRQVEALERAAREKEALA 875

Query: 335  KQVVMQAMGSCRMRGGRQAALREVEQIQALEDKKEKEMSAVRLENIQLKQSLVHFETRMR 394
            K+    A+          AA RE   +        +E + +RLE   L+ SL        
Sbjct: 876  KEHAGLAVQLV-------AAEREGRTL-------SEEATRLRLEKEALEGSL------FE 915

Query: 395  TQEDLTQGLLLIDFEQLKIENQTFNEKIEERNEELLKLRSKVTNSVQVITHVKEKLHFMD 454
             Q  L Q  L    EQL+ E Q      E    EL  LR ++     + T  K  L   D
Sbjct: 916  VQRQLAQ--LEARREQLEAEGQALLLAKETLTGELAGLRQQI-----IATQEKASL---D 965

Query: 455  MENACKKTQLAEIEAQAALGRDILTKTKQAREGLRTDNIRLNQKCGLLGKDSLLRDLE-E 513
             E   +K   AE EAQA+L        ++ R     D  RL ++     K++  R+LE E
Sbjct: 966  KELMAQKLVQAEREAQASL--------REQRAAHEEDLQRLQRE-----KEAAWRELEAE 1012

Query: 514  KVDKTELLHRRLESL 528
            +      L R  E L
Sbjct: 1013 RAQLQSQLQREQEEL 1027



 Score = 45.8 bits (107), Expect = 1e-04
 Identities = 100/486 (20%), Positives = 188/486 (38%), Gaps = 41/486 (8%)

Query: 84   PGEPGRPAEPQPEPE---EPAEVGAEEPAQPEPGAGPEELEAEAGAEELEQAAEGKEVRF 140
            PG P R A  +   E    P+ +     +QP P  GP    A    +   +A  G    F
Sbjct: 1458 PGSPARDAPAEGSGEGLNSPSTLECSPGSQP-PSPGPATSPASPDLDP--EAVRGALREF 1514

Query: 141  QASLPLTRIDEEEAAAAPEAETERVEGEEEDKEETQRDGAESKERDGEGRPAKSQEEGKR 200
               L   + + +E      A   ++      + E +RD A S+ R  +   A+S+E  + 
Sbjct: 1515 LQELRSAQRERDELRTQTSALNRQLA-----EMEAERDSATSRARQLQKAVAESEEARRS 1569

Query: 201  LYGR--DEFEDLEWSEEVQKLQEQQLRSDLLDQYRSLLVERNRSQRYNLYLQHKIFEALR 258
            + GR      +L   EE  +  E++ R+  LDQ  +L      ++      Q KI +   
Sbjct: 1570 VDGRLSGVQAELALQEESVRRSERERRA-TLDQVATLERSLQATESELRASQEKISK--- 1625

Query: 259  RKKGLEAAEVADRGAEAEAPEKEQAYLRHLGMLEELKKQQADDLQWYHQELGQLKRQCQE 318
                ++A E    G +    E   A       LE  ++    +LQ     L   + Q Q 
Sbjct: 1626 ----MKANETKLEGDKRRLKEVLDASESRTVKLELQRRSLEGELQRSRLGLSDREAQAQA 1681

Query: 319  KLTRVEKEWRRFQALKKQVVMQAMGSCRMRGGRQAALREVEQIQ-ALEDK---------- 367
               RV+   R+    + +     +   R+ G    AL +VE+ + AL DK          
Sbjct: 1682 LQDRVDSLQRQVADSEVKAGTLQLTVERLNG----ALAKVEESEGALRDKVRGLTEALAQ 1737

Query: 368  KEKEMSAVRLENIQLKQSLVHFE-TRMRTQEDLTQGLLLIDFEQLKIENQTFNEKIEERN 426
                +++ R +N+ L+++L   E  R   QE L      +   + + ++ +  E+++   
Sbjct: 1738 SSASLNSTRDKNLHLQKALTACEHDRQVLQERLDAARQAL--SEARKQSSSLGEQVQTLR 1795

Query: 427  EELLKLRSKVTNSVQVITHVKEKLHFMDMENACKKTQLAEIEAQAALGRDILTKTKQARE 486
             E+  L  +   +   +  ++E L       A     + +++ +  L ++ L   ++A  
Sbjct: 1796 GEVADLELQRVEAEGQLQQLREVLRQRQEGEAAALNTVQKLQDERRLLQERLGSLQRALA 1855

Query: 487  GLRTDNIRLNQKCGLLGKDSL-LRDLEEKVDKTEL-LHRRLESLKRHHASLTLSCRGVRQ 544
             L  +   + +    L KD + LR   +KV++ +L  H     L      L  +  G   
Sbjct: 1856 QLEAEKREVERSALRLEKDRVALRRTLDKVEREKLRSHEDTVRLSAEKGRLDRTLTGAEL 1915

Query: 545  KIREAK 550
            ++ EA+
Sbjct: 1916 ELAEAQ 1921



 Score = 41.6 bits (96), Expect = 0.002
 Identities = 106/546 (19%), Positives = 210/546 (38%), Gaps = 76/546 (13%)

Query: 13   GEGGDGES-LAARPSKIKASSGPPTSPEPGELESEPEEEEEEQAASQGGTAADEQAEAPK 71
            GEG +  S L   P     S GP TSP   +L+ E       +   +  +A  E+ E   
Sbjct: 1471 GEGLNSPSTLECSPGSQPPSPGPATSPASPDLDPEAVRGALREFLQELRSAQRERDELRT 1530

Query: 72   GLTAAEAAGEEGPGEPGRPAEPQPEPEEPAEVGAEEPAQPEPGAGPEELEAEAGAEELEQ 131
              +A                       + AE+ AE  +        ++  AE  +EE  +
Sbjct: 1531 QTSALN--------------------RQLAEMEAERDSATSRARQLQKAVAE--SEEARR 1568

Query: 132  AAEGKEVRFQASLPLTRIDEEEAAAAPEAETERVEGEEEDKEETQRDGAESKERDGEGRP 191
            + +G+    QA L L       +     A  ++V   E   + T+ +   S+E+  + + 
Sbjct: 1569 SVDGRLSGVQAELALQEESVRRSERERRATLDQVATLERSLQATESELRASQEKISKMKA 1628

Query: 192  AKSQEEGKRLYGRDEFEDLEWSEEVQKLQEQQLRSDLLDQYRSLLVERNRSQRYNLY--- 248
             +++ EG +   ++  +  E      +LQ + L  +L  Q   L +    +Q   L    
Sbjct: 1629 NETKLEGDKRRLKEVLDASESRTVKLELQRRSLEGEL--QRSRLGLSDREAQAQALQDRV 1686

Query: 249  --LQHKIFEALRRKKGLEAAEVADRGAEAEAPEKEQAYLRHLGMLEELKKQQADDLQWYH 306
              LQ ++ ++  +   L+       GA A+  E E A    +  L E   Q +  L    
Sbjct: 1687 DSLQRQVADSEVKAGTLQLTVERLNGALAKVEESEGALRDKVRGLTEALAQSSASLNSTR 1746

Query: 307  QELGQLKRQCQEKLTRVEKEWRRFQALKKQVVMQAMGSCR--MRGGRQAALREVEQIQAL 364
             +        Q+ LT  E +        +QV+ + + + R  +   R+ +    EQ+Q L
Sbjct: 1747 DK----NLHLQKALTACEHD--------RQVLQERLDAARQALSEARKQSSSLGEQVQTL 1794

Query: 365  EDKKEKEMSAVRLENIQLKQSLVHFETRMRTQEDLTQGLLLIDFEQLKIENQTFNEKIEE 424
                  E++ + L+ ++ +  L      +R +++  +   L   ++L+ E +   E++  
Sbjct: 1795 RG----EVADLELQRVEAEGQLQQLREVLRQRQE-GEAAALNTVQKLQDERRLLQERLGS 1849

Query: 425  RNEELLKLRSKVTNSVQVITHVKEKLHFMDMENACKKTQLAEIEAQAALGRDILTKTKQA 484
                L +L ++                    +   +++ L   + + AL R   T  K  
Sbjct: 1850 LQRALAQLEAE--------------------KREVERSALRLEKDRVALRR---TLDKVE 1886

Query: 485  REGLRT--DNIRLNQKCGLLGKDSLLRDLE--EKVDKTELLHRRLESLKRHHASLTLSCR 540
            RE LR+  D +RL+ + G L +     +LE  E   + + L  ++  L++ H+   L   
Sbjct: 1887 REKLRSHEDTVRLSAEKGRLDRTLTGAELELAEAQRQIQQLEAQVVVLEQSHSPAQLEVD 1946

Query: 541  GVRQKI 546
              +Q++
Sbjct: 1947 AQQQQL 1952



 Score = 35.0 bits (79), Expect = 0.18
 Identities = 61/240 (25%), Positives = 94/240 (39%), Gaps = 18/240 (7%)

Query: 169  EEDKEETQRDGAESKERDGEGRPAKSQEEGKRLYGRDEFEDLEWSEEVQKLQEQQLRSDL 228
            E D++  Q     +++   E R   S    +    R E  DLE      + Q QQLR  L
Sbjct: 1760 EHDRQVLQERLDAARQALSEARKQSSSLGEQVQTLRGEVADLELQRVEAEGQLQQLREVL 1819

Query: 229  LDQYRSLLVERNRSQRYN---LYLQHKIFEALRRKKGLEAAEVADRGAEAEAPEKEQAYL 285
              +        N  Q+       LQ ++    R    LEA E  +    A   EK++  L
Sbjct: 1820 RQRQEGEAAALNTVQKLQDERRLLQERLGSLQRALAQLEA-EKREVERSALRLEKDRVAL 1878

Query: 286  RH-LGMLEELKKQQADDLQWYHQELGQLKRQCQEKLTRVEKEWRRFQALKKQVVMQAMGS 344
            R  L  +E  K +  +D      E G+L R        + +  R+ Q L+ QVV+     
Sbjct: 1879 RRTLDKVEREKLRSHEDTVRLSAEKGRLDRTLTGAELELAEAQRQIQQLEAQVVV----- 1933

Query: 345  CRMRGGRQAALREVE-QIQALEDKKEKEMSAVRLENIQLKQSLVHFETRMRTQEDLTQGL 403
              +      A  EV+ Q Q LE   ++E+  +R    Q +++L   E R R      +GL
Sbjct: 1934 --LEQSHSPAQLEVDAQQQQLE--LQQEVERLRSAQAQTERTL---EARERAHRQRVRGL 1986


>gi|118601081 heterogeneous nuclear ribonucleoprotein U-like 2 [Homo
           sapiens]
          Length = 747

 Score = 69.3 bits (168), Expect = 9e-12
 Identities = 71/247 (28%), Positives = 98/247 (39%), Gaps = 43/247 (17%)

Query: 12  GGEGGDGESLAARPSKIKASSGPPTSPEPGELESEPEEEEEEQAASQGGTAADEQAEAPK 71
           GG  G G +  A P  + AS G P   E    E E EEEE+E+A  +     DE  E P 
Sbjct: 48  GGGAGPGGACKAEPRPVAASGGGPGGDEE---EDEEEEEEDEEALLE-----DEDEEPPP 99

Query: 72  GLTAAEAAGEEGPGEPGRPAEPQPEPEEPAEVGAEEPAQPEPGAGPEELEA-EAGAEELE 130
                +AA              QP PE P     E  A+P+    P E  A   G    E
Sbjct: 100 AQALGQAA--------------QPPPEPPEAAAMEAAAEPDASEKPAEATAGSGGVNGGE 145

Query: 131 QAAEGKEVRFQASLPLTRI-DEEEAAAAPEAETERVEGEEEDKEETQRDGAESKERDGEG 189
           +   GK    +   P  R  DE   +  P  +    +G+++D E+++  G+     DGE 
Sbjct: 146 EQGLGKR---EEDEPEERSGDETPGSEVPGDKAAEEQGDDQDSEKSKPAGS-----DGER 197

Query: 190 RPAKSQEEGKRLYGRDEFEDLEWS-----------EEVQKLQEQQLRSDLLDQYRSLLVE 238
           R  K Q + K  +GR  +E  E +           EE  K +E+      LD Y S L  
Sbjct: 198 RGVKRQRDEKDEHGRAYYEFREEAYHSRSKSPLPPEEEAKDEEEDQTLVNLDTYTSDLHF 257

Query: 239 RNRSQRY 245
           +    RY
Sbjct: 258 QVSKDRY 264


>gi|88196790 coiled-coil domain containing 88 [Homo sapiens]
          Length = 1476

 Score = 66.2 bits (160), Expect = 7e-11
 Identities = 140/620 (22%), Positives = 235/620 (37%), Gaps = 115/620 (18%)

Query: 1    MDVSSEHTKDPGGEGGDGES-LAARPSKIKASS-GPPTSPEPGELESEPEEEEEEQAASQ 58
            ++ S+E  + P  +  + ES L A     +AS   P  S  P E +  PE+     +   
Sbjct: 541  LEASAECPQAPDSDPQEAESPLQAAAMDPQASDWSPQESGSPVETQESPEKAGRRSSLQS 600

Query: 59   GGTAADEQA------------------EAPKGLTAAEAAG--EEGPGEPGRPAEPQPEPE 98
              + A  Q                   EAP+G    EA G  +EGP       E +P P 
Sbjct: 601  PASVAPPQGPGTKIQAPQLLGGETEGREAPQGELVPEAWGLRQEGP-------EHKPGPS 653

Query: 99   EPAEVGAEEPAQPEPGAGPEELEAEAGAEELEQAAEGK-----------------EVR-F 140
            EP+ V  EE  Q  P  G +    +A A E +Q  EG                  EV+ +
Sbjct: 654  EPSSVQLEE--QEGPNQGLDLATGQAEAREHDQRLEGTVRDPAWQKPQQKSEGALEVQVW 711

Query: 141  QASLP----LTRIDEEEAAAAPEAETERVEGEEEDKEETQRDGAESKERDGE------GR 190
            +  +P     + + E+EA     A+  R      D+ E Q    E++  +         +
Sbjct: 712  EGPIPGESLASGVAEQEALREEVAQLRRKAEALGDELEAQARKLEAQNTEAARLSKELAQ 771

Query: 191  PAKSQEEGKRLYGRDEFEDLEWSEEVQKLQEQ-----QLRSDLLDQYRSLLVERNRSQRY 245
              +++ E  R      +E     E V+   ++     Q R  L++   +   ER + +R 
Sbjct: 772  ARRAEAEAHREAEAQAWEQARLREAVEAAGQELESASQEREALVEALAAAGRERRQWERE 831

Query: 246  NLYLQHKIFEALRR--------KKGLEAAEVADRGAEAEAPEKEQAYLRHLGMLEELKKQ 297
               L+ +   A  R        ++ LE AE   R  EA   E E+A +R         K+
Sbjct: 832  GSRLRAQSEAAEERMQVLESEGRQHLEEAERERREKEALQAELEKAVVR--------GKE 883

Query: 298  QADDLQWYHQELGQLKRQCQEKLTRVEKEWRRFQALKKQVVMQAMGSCRMRGGRQAALRE 357
                L+   +EL Q   + QE L   E + +R+Q L++          R+    QAA   
Sbjct: 884  LGARLEHLQRELEQAALERQEFLREKESQHQRYQGLEQ----------RLEAELQAAATS 933

Query: 358  VEQIQALEDKKEKEMSAVRLENIQLKQSLVHFETRMRTQEDL--TQGLLLIDFEQ----L 411
             E  +AL + K + +  +  E  QL+Q       + R +  L  TQ + LI+ E+    L
Sbjct: 934  KE--EALMELKTRALQ-LEEELFQLRQGPAGLGPKKRAEPQLVETQNVRLIEVERSNAML 990

Query: 412  KIENQTFNEKIEERNEELLKLRSKVTNSVQVITHVKEKLHFMDMENACKKTQ-------L 464
              E      +++    +L  L+ +    +      +E    +  E +  + Q       L
Sbjct: 991  VAEKAALQGQLQHLEGQLGSLQGRAQELLLQSQRAQEHSSRLQAEKSVLEIQGQELHRKL 1050

Query: 465  AEIEAQAALGRDILTKTKQAREGLRTDN-----IRLNQKCGLLGKDSLLRDLEEKVDKTE 519
              +E +    R    +T+  ++ L  D+     ++  Q+  L G     RDL+  +   E
Sbjct: 1051 EVLEEEVRAARQSQEETRGQQQALLRDHKALAQLQRRQEAELEGLLVRHRDLKANMRALE 1110

Query: 520  LLHRRL----ESLKRHHASL 535
            L HR L    E L+   AS+
Sbjct: 1111 LAHRELQGRHEQLQAQRASV 1130



 Score = 59.7 bits (143), Expect = 7e-09
 Identities = 98/432 (22%), Positives = 174/432 (40%), Gaps = 41/432 (9%)

Query: 92   EPQPEPEEPAEVGAEEPAQPEPGAGPEELEAEAGAEELEQAAEGKEVRFQASLPLTR--- 148
            E + E E  A   ++E A  E      +LE E        A  G + R +  L  T+   
Sbjct: 920  EQRLEAELQAAATSKEEALMELKTRALQLEEELFQLRQGPAGLGPKKRAEPQLVETQNVR 979

Query: 149  -IDEEEAAAAPEAETERVEGEEEDKEETQRDGAESKERDGEGRPAKSQEEGKRLYGRDEF 207
             I+ E + A   AE   ++G+ +  E  Q    + + ++   +  ++QE   RL      
Sbjct: 980  LIEVERSNAMLVAEKAALQGQLQHLEG-QLGSLQGRAQELLLQSQRAQEHSSRLQAEKSV 1038

Query: 208  EDLEWSEEVQKLQ--EQQLRSDLLDQYRSLLVERNRSQRYNLYLQHKIFEALRRKKG--L 263
             +++  E  +KL+  E+++R+    Q      E  R Q+  L   HK    L+R++   L
Sbjct: 1039 LEIQGQELHRKLEVLEEEVRAARQSQ------EETRGQQQALLRDHKALAQLQRRQEAEL 1092

Query: 264  EAAEVADRGAEAEAPEKEQAYLRHLGMLEELKKQQADDLQWYHQELGQLKRQCQE--KLT 321
            E   V  R  +A     E A+    G  E+L+ Q+A         L + +R  Q+  +  
Sbjct: 1093 EGLLVRHRDLKANMRALELAHRELQGRHEQLQAQRASVEAQEVALLAERERLMQDGHRQR 1152

Query: 322  RVEKEWRRFQALKKQVVMQAMGSCRMRG----------GRQAALR------EVEQIQALE 365
             +E+E RR Q+   +  M      R RG          GR A L       E++  Q  E
Sbjct: 1153 GLEEELRRLQSEHDRAQMLLAELSRERGELQGERGELRGRLARLELERAQLEMQSQQLRE 1212

Query: 366  DKKEKEMSAVRLENIQLKQSLVHFETRMRTQEDLTQGLLLIDFEQLKIENQTFNEKIEER 425
              ++ ++SA RL       +     T++R+ ++     LL + + L  EN+   E+  E 
Sbjct: 1213 SNQQLDLSACRLT------TQCELLTQLRSAQEEENRQLLAEVQALSRENRELLERSLES 1266

Query: 426  NEELLKLRSKVTNSVQVITHVKEKL--HFMDMENACKKTQLAEIEAQAALGRDILTKTKQ 483
             + L + + +  + +  +   K+KL    MD     +   L   +  + L   +    + 
Sbjct: 1267 RDHLHREQREYLDQLNALRREKQKLVEKIMDQYRVLEPVPLPRTKKGSWLADKVKRLMRP 1326

Query: 484  AREGLRTDNIRL 495
             REG     +RL
Sbjct: 1327 RREGGPPGGLRL 1338


>gi|44680105 caldesmon 1 isoform 1 [Homo sapiens]
          Length = 793

 Score = 65.5 bits (158), Expect = 1e-10
 Identities = 90/414 (21%), Positives = 175/414 (42%), Gaps = 40/414 (9%)

Query: 41  GELESEP--EEEEEEQAASQGGTAADEQAEAPKGLTAAEAAGEEGPGEPGRPAEPQPEPE 98
           G++ SE   +EEE EQ + +       + E  +   A  A  E    E  +  + +   +
Sbjct: 231 GQISSEEPKQEEEREQGSDEISHHEKMEEEDKERAEAERARLEAEERERIKAEQDKKIAD 290

Query: 99  EPAEVGAEEPAQPEPGAGPEELEAEAGAEELEQAAEGKEVRFQASLPLTRIDEEEAAAAP 158
           E A + AEE A  +     E  E E   EE ++AAE ++          RI EEE  AA 
Sbjct: 291 ERARIEAEEKAAAQERERREAEERERMREEEKRAAEERQ----------RIKEEEKRAA- 339

Query: 159 EAETERVEGEEEDKEETQRDGAESKERDGEGRPAKSQEEGKRLYGRDEFEDLEWSEEVQK 218
             E +R++ EE+   E ++   E ++R  E R     EE ++    ++  + +  E+   
Sbjct: 340 -EERQRIKEEEKRAAEERQRIKEEEKRAAEERQRARAEEEEKAKVEEQKRNKQLEEKKHA 398

Query: 219 LQEQQLRSDLLDQ-YRSLLVERNRSQRYNLYLQHKIFEALRRKKGLEAAEVADRGAEAEA 277
           +QE +++ + ++Q      V   ++Q     LQ  + +    +KG +     ++  E + 
Sbjct: 399 MQETKIKGEKVEQKIEGKWVNEKKAQEDK--LQTAVLKKQGEEKGTKVQAKREKLQEDKP 456

Query: 278 PEKEQAYLRHLGMLEELKKQQADDLQWYHQELGQLKRQCQE----KLTRVEKEWRRFQAL 333
             K++         ++  K++        +   ++K Q  E    KL   E  + R    
Sbjct: 457 TFKKEEIKDEKIKKDKEPKEEVKSFMDRKKGFTEVKSQNGEFMTHKLKHTENTFSRPGGR 516

Query: 334 KKQVVMQAMGSCRMRGG-------RQAALREVEQIQALEDKKEKEMSAVRLENIQLK--- 383
                 +A G+ ++  G       R+    E E+ + L+ K+++  +A+ LE ++ K   
Sbjct: 517 ASVDTKEAEGAPQVEAGKRLEELRRRRGETESEEFEKLKQKQQE--AALELEELKKKREE 574

Query: 384 -QSLVHFETRMRTQEDLTQGLLLIDFEQLKIENQTFNEKIEERNEELLKLRSKV 436
            + ++  E + R QE+  + L      + + E +   E+IE R  E  + R K+
Sbjct: 575 RRKVLEEEEQRRKQEEADRKL------REEEEKRRLKEEIERRRAEAAEKRQKM 622



 Score = 48.5 bits (114), Expect = 2e-05
 Identities = 105/501 (20%), Positives = 190/501 (37%), Gaps = 85/501 (16%)

Query: 17  DGESLAARPSKIKASSGPPTSPEPGELESEPEEEEEEQAASQGGTAADEQA---EAPKGL 73
           D E  AAR  + +A            L  + EEE   Q   Q    A       EA    
Sbjct: 32  DDEEEAARERRRRARQE--------RLRQKQEEESLGQVTDQVEVNAQNSVPDEEAKTTT 83

Query: 74  TAAEAAGEEGPGEPGRPAEPQPEPEEPAEVGAEEPAQPEPGAGPEELE----------AE 123
           T  +  G++      R A  +   ++  +   E   + +P      L           AE
Sbjct: 84  TNTQVEGDDEAAFLERLARREERRQKRLQEALERQKEFDPTITDASLSLPSRRMQNDTAE 143

Query: 124 AGAEELEQAAEGKEVRFQASLPLT---RIDEEEAAAAPEAETERVEGEEEDKEETQRDG- 179
               E E+ +E ++ R++     T      + +   A E + E  E EEE++E+ +R   
Sbjct: 144 NETTEKEEKSESRQERYEIEETETVTKSYQKNDWRDAEENKKEDKEKEEEEEEKPKRGSI 203

Query: 180 -------------AESKE-------RDGEGRPAKSQEEGKRLYGRDEFEDLEWSEEVQKL 219
                         ES+E       ++G+    + ++E +R  G DE    E  EE  K 
Sbjct: 204 GENQVEVMVEEKTTESQEETVVMSLKNGQISSEEPKQEEEREQGSDEISHHEKMEEEDK- 262

Query: 220 QEQQLRSDLLDQYRSLLVERNRSQRYNLYLQHKIFEALRRKKGLEAAEVADRGAEAEAPE 279
                             ER  ++R  L  + +      R K  +  ++AD  A  EA E
Sbjct: 263 ------------------ERAEAERARLEAEER-----ERIKAEQDKKIADERARIEAEE 299

Query: 280 KEQAYLRHLGMLEELKKQQADDLQ--WYHQELGQLKRQCQEKLTRVEKEWRRF----QAL 333
           K  A  R     EE ++ + ++ +     Q + + +++  E+  R+++E +R     Q +
Sbjct: 300 KAAAQERERREAEERERMREEEKRAAEERQRIKEEEKRAAEERQRIKEEEKRAAEERQRI 359

Query: 334 KKQVVMQAMGSCRMRGGRQ--AALREVEQIQALEDKKEKEMSAVRLENIQLKQSLV-HFE 390
           K++    A    R R   +  A + E ++ + LE+KK   M   +++  +++Q +   + 
Sbjct: 360 KEEEKRAAEERQRARAEEEEKAKVEEQKRNKQLEEKKH-AMQETKIKGEKVEQKIEGKWV 418

Query: 391 TRMRTQED-LTQGLLLIDFEQLKIENQTFNEKIEERNEELLKLRSKVTNSVQVITHVKEK 449
              + QED L   +L    E+   + Q   EK++E      K   K     +     +E 
Sbjct: 419 NEKKAQEDKLQTAVLKKQGEEKGTKVQAKREKLQEDKPTFKKEEIKDEKIKKDKEPKEEV 478

Query: 450 LHFMDMENACKKTQLAEIEAQ 470
             FMD     +K    E+++Q
Sbjct: 479 KSFMD-----RKKGFTEVKSQ 494



 Score = 38.5 bits (88), Expect = 0.016
 Identities = 35/123 (28%), Positives = 54/123 (43%), Gaps = 16/123 (13%)

Query: 105 AEEPAQPEPGAGPEELEAEAGAEELEQAAEGKEVRFQASLPLTRIDEEEAAAAPEAETER 164
           AE   Q E G   EEL    G  E E+  + K+ + +A+L L     EE     E   + 
Sbjct: 524 AEGAPQVEAGKRLEELRRRRGETESEEFEKLKQKQQEAALEL-----EELKKKREERRKV 578

Query: 165 VEGEEEDKEETQRDGAESKERDGEGRPAKSQEEGKRLYGRDEFEDLEWSEEVQKLQEQQL 224
           +E EE+ +++ + D           R  + +EE +RL    E    E +E+ QK+ E  L
Sbjct: 579 LEEEEQRRKQEEAD-----------RKLREEEEKRRLKEEIERRRAEAAEKRQKMPEDGL 627

Query: 225 RSD 227
             D
Sbjct: 628 SDD 630


>gi|116284396 myosin, heavy chain 14 isoform 1 [Homo sapiens]
          Length = 2003

 Score = 64.3 bits (155), Expect = 3e-10
 Identities = 126/562 (22%), Positives = 218/562 (38%), Gaps = 58/562 (10%)

Query: 43   LESEPEEEEEEQAASQGGTAADEQAEAPKGLTAAEAAGEEGPGEPGRPAEPQPEPEEPAE 102
            LE+E  E   E ++ Q      EQ      L   E  G  G GE  R    +      AE
Sbjct: 1254 LEAEVSELRAELSSLQTARQEGEQRRRRLELQLQEVQGRAGDGERARAEAAEKLQRAQAE 1313

Query: 103  VGAEEPAQPEPGAGPEELEAEAGAEE--LEQAAEGKEVRFQASLPL---TRIDEEEAAAA 157
            +     A  E  +    L  E  + E  L  A E  +   +A L L    R  E EAA  
Sbjct: 1314 LENVSGALNEAESKTIRLSKELSSTEAQLHDAQELLQEETRAKLALGSRVRAMEAEAAGL 1373

Query: 158  PEAETERVEGEEEDKEETQRDGAESKE----RDGEGRPAKSQEEGKRLYGRDEFEDL--- 210
             E   E     E    E Q   A+  E    ++ E    ++ EE +R   R E E L   
Sbjct: 1374 REQLEEEAAARERAGRELQTAQAQLSEWRRRQEEEAGALEAGEEARRRAAR-EAEALTQR 1432

Query: 211  --EWSEEVQKLQ--EQQLRSDL------LDQYRSLLVERNRSQR-YNLYLQHKIFEALRR 259
              E +E V +L+   ++L+ +L      L+Q R L+    + QR ++  L  +    LR 
Sbjct: 1433 LAEKTETVDRLERGRRRLQQELDDATMDLEQQRQLVSTLEKKQRKFDQLLAEEKAAVLRA 1492

Query: 260  KKGLEAAEVADRGAEAEAPEKEQAYLRHLGMLEELKKQQADDLQWYHQELGQLKRQCQEK 319
             +  E AE   R  EA A    +A        EEL++Q    L+   + L   K    + 
Sbjct: 1493 VEERERAEAEGREREARALSLTRALEEEQEAREELERQNR-ALRAELEALLSSKDDVGKS 1551

Query: 320  LTRVEKEWRRFQALKKQVVMQAMG-SCRMRGGRQAALREVEQIQALEDKKEKEMS----- 373
            +  +E+  R  +     +  Q       +     A LR    +QAL+ + E+++      
Sbjct: 1552 VHELERACRVAEQAANDLRAQVTELEDELTAAEDAKLRLEVTVQALKTQHERDLQGRDEA 1611

Query: 374  --------AVRLENIQLKQSLVHFETRMRTQEDLTQGLLLIDFEQLKIENQTFNEKIEER 425
                    A +L + ++++     E + RT     +  L  + E+LK +  +  +  EE 
Sbjct: 1612 GEERRRQLAKQLRDAEVERD---EERKQRTLAVAARKKLEGELEELKAQMASAGQGKEEA 1668

Query: 426  NEELLKLRSKVTNSVQVITHVKEKLHFMDMENACKKTQLAEIEAQAALGRDILTKTKQAR 485
             ++L K+++++    + +   +     +  +N   + +L  +EA+    ++ L  + +AR
Sbjct: 1669 VKQLRKMQAQMKELWREVEETRTSREEIFSQNRESEKRLKGLEAEVLRLQEELAASDRAR 1728

Query: 486  EGLRTDNIRLNQKC--GLLGKDSLL--------------RDLEEKVDKTELLHRRLESLK 529
               + D   +  +   G L K ++L               +LEE+   +ELL+ R   L 
Sbjct: 1729 RQAQQDRDEMADEVANGNLSKAAILEEKRQLEGRLGQLEEELEEEQSNSELLNDRYRKLL 1788

Query: 530  RHHASLTLSCRGVRQKIREAKA 551
                SLT      R    +A++
Sbjct: 1789 LQVESLTTELSAERSFSAKAES 1810



 Score = 56.2 bits (134), Expect = 8e-08
 Identities = 108/487 (22%), Positives = 201/487 (41%), Gaps = 69/487 (14%)

Query: 126  AEELEQAAEGKEVRFQASLPLTRIDEEEAAAAPEAETERVEGEEEDKE-ETQRDGAESKE 184
            AE+LEQA  GK    +  L L     E  A     +T R EGE+  +  E Q    + + 
Sbjct: 1234 AEQLEQARRGKGAWEKTRLALEAEVSELRAELSSLQTARQEGEQRRRRLELQLQEVQGRA 1293

Query: 185  RDGEGRPAKSQEEGKR----------LYGRDEFEDLEWSEEV----------QKLQEQQL 224
             DGE   A++ E+ +R               E + +  S+E+          Q+L +++ 
Sbjct: 1294 GDGERARAEAAEKLQRAQAELENVSGALNEAESKTIRLSKELSSTEAQLHDAQELLQEET 1353

Query: 225  RSDLL----------------DQYRSLLVERNRSQRYNLYLQHKIFEALRRKK----GLE 264
            R+ L                 +Q       R R+ R     Q ++ E  RR++     LE
Sbjct: 1354 RAKLALGSRVRAMEAEAAGLREQLEEEAAARERAGRELQTAQAQLSEWRRRQEEEAGALE 1413

Query: 265  AAEVADRGAEAEAPEKEQAYLRHLGMLEELKKQQADDLQWYHQELGQLKRQCQEKLTRVE 324
            A E A R A  EA    Q        ++ L++ +    Q        L++Q ++ ++ +E
Sbjct: 1414 AGEEARRRAAREAEALTQRLAEKTETVDRLERGRRRLQQELDDATMDLEQQ-RQLVSTLE 1472

Query: 325  KEWRRFQAL---KKQVVMQAMGSCRMRG---GRQAALREVEQIQALEDKKEKEMSAVRLE 378
            K+ R+F  L   +K  V++A+   R R    GR+   R +   +ALE+++E      R +
Sbjct: 1473 KKQRKFDQLLAEEKAAVLRAVEE-RERAEAEGREREARALSLTRALEEEQEAREELER-Q 1530

Query: 379  NIQLKQSLVHFETRMRTQEDLTQGLLLIDFEQLKIENQTFNE---KIEERNEEL-----L 430
            N  L+  L   E  + +++D+ + +  ++    ++  Q  N+   ++ E  +EL      
Sbjct: 1531 NRALRAEL---EALLSSKDDVGKSVHELE-RACRVAEQAANDLRAQVTELEDELTAAEDA 1586

Query: 431  KLRSKVTNSVQVITHVKEKLHFMDMENACKKTQLAEIEAQAALGRDILTKTK----QARE 486
            KLR +VT       H ++ L   D     ++ QLA+    A + RD   K +     AR+
Sbjct: 1587 KLRLEVTVQALKTQHERD-LQGRDEAGEERRRQLAKQLRDAEVERDEERKQRTLAVAARK 1645

Query: 487  GL--RTDNIRLNQKCGLLGKDSLLRDLEEKVDKTELLHRRLESLKRHHASLTLSCRGVRQ 544
             L    + ++        GK+  ++ L +   + + L R +E  +     +    R   +
Sbjct: 1646 KLEGELEELKAQMASAGQGKEEAVKQLRKMQAQMKELWREVEETRTSREEIFSQNRESEK 1705

Query: 545  KIREAKA 551
            +++  +A
Sbjct: 1706 RLKGLEA 1712



 Score = 52.8 bits (125), Expect = 8e-07
 Identities = 91/383 (23%), Positives = 161/383 (42%), Gaps = 65/383 (16%)

Query: 46   EPEEEEEEQAASQGGTAADEQAEAPKGLTAAEAAGEEGPGEPGRPAEPQPEPEEPAEVGA 105
            E  EE   Q A Q   A  E+ E  K  T A AA ++  GE           E  A++ +
Sbjct: 1610 EAGEERRRQLAKQLRDAEVERDEERKQRTLAVAARKKLEGEL---------EELKAQMAS 1660

Query: 106  EEPAQPEPGAGPEELEAEAGA--EELEQAAEGKEVRFQASLPLTRIDEEEAAAAPEAETE 163
                + E      +++A+      E+E+    +E  F  +      + E+     EAE  
Sbjct: 1661 AGQGKEEAVKQLRKMQAQMKELWREVEETRTSREEIFSQNR-----ESEKRLKGLEAEVL 1715

Query: 164  RVEGE----EEDKEETQRDGAESKERDGEGRPAKSQ--EEGKRLYGRDEFEDLEWSEEVQ 217
            R++ E    +  + + Q+D  E  +    G  +K+   EE ++L GR     LE     +
Sbjct: 1716 RLQEELAASDRARRQAQQDRDEMADEVANGNLSKAAILEEKRQLEGR--LGQLE-----E 1768

Query: 218  KLQEQQLRSDLL-DQYRSLLV-----------ERNRSQRYNLYLQH--KIFEALRRKKGL 263
            +L+E+Q  S+LL D+YR LL+           ER+ S +     Q   +  + LR + G 
Sbjct: 1769 ELEEEQSNSELLNDRYRKLLLQVESLTTELSAERSFSAKAESGRQQLERQIQELRGRLGE 1828

Query: 264  EAAEVADRGAEAEAPEKEQAYLRHLGMLEELKKQQADDLQWYHQELGQLKRQCQEKLTRV 323
            E     D GA A       A    L   EE  +Q+  +     + + + +++ +E + +V
Sbjct: 1829 E-----DAGARARHKMTIAALESKLAQAEEQLEQETRERILSGKLVRRAEKRLKEVVLQV 1883

Query: 324  EKEWR--------------RFQALKKQVVMQAMGSCRMRGGRQAALREVEQIQALEDKKE 369
            E+E R              R + LK+Q+      + R + GR+   RE+E +    +   
Sbjct: 1884 EEERRVADQLRDQLEKGNLRVKQLKRQLEEAEEEASRAQAGRRRLQRELEDVTESAESMN 1943

Query: 370  KEMSAVRLENIQLKQSLVHFETR 392
            +E++ +R    +L++  + F TR
Sbjct: 1944 REVTTLR---NRLRRGPLTFTTR 1963



 Score = 40.8 bits (94), Expect = 0.003
 Identities = 127/566 (22%), Positives = 218/566 (38%), Gaps = 96/566 (16%)

Query: 39   EPGELESEPEEEEEEQAASQGGTAADEQAEAPKGLTAAEAAGEEGPGEPGRPAEPQPEPE 98
            E GEL+    + EEE+A      A   +AEA     A E  G        R  E +    
Sbjct: 899  EVGELQGRVAQLEEERAR----LAEQLRAEAELCAEAEETRGRLA----ARKQELELVVS 950

Query: 99   E-PAEVGAEEPAQPEPGAGPEEL-----------EAEAGAEELEQ----AAEGKEVRFQA 142
            E  A VG EE    +     + L           EAE GA +  Q      E K  +F+ 
Sbjct: 951  ELEARVGEEEECSRQMQTEKKRLQQHIQELEAHLEAEEGARQKLQLEKVTTEAKMKKFEE 1010

Query: 143  SLPLT----------------RIDEEEAAAAPEAET-----------ERVEGEEED---K 172
             L L                 R+ E  + AA E E            E    + ED   K
Sbjct: 1011 DLLLLEDQNSKLSKERKLLEDRLAEFSSQAAEEEEKVKSLNKLRLKYEATIADMEDRLRK 1070

Query: 173  EETQRDGAESKERDGEGRPAKSQEEGKRLYGRDEFEDLEWSEEVQKLQEQQLRSDLLDQY 232
            EE  R   E  +R  +G  ++ QE+      R E    +   + ++LQ    R++     
Sbjct: 1071 EEKGRQELEKLKRRLDGESSELQEQMVEQQQRAEELRAQLGRKEEELQAALARAEDEGGA 1130

Query: 233  RSLLVERNRSQRYNLYLQHKIFEALRRKKGLEAAEVADRGAEAEAPEKE-QAYLRHLGML 291
            R+ L++  R  +  L    +  E+ R  +     +  D G E EA   E +  L      
Sbjct: 1131 RAQLLKSLREAQAALAEAQEDLESERVARTKAEKQRRDLGEELEALRGELEDTLDSTNAQ 1190

Query: 292  EELKKQQADDLQWYHQELGQLKRQCQEKLTRV------EKEWRRFQA---LKKQVVMQAM 342
            +EL+ ++        QE+ +LK+  +E+ TR+      E   R  QA   L +Q+     
Sbjct: 1191 QELRSKR-------EQEVTELKKTLEEE-TRIHEAAVQELRQRHGQALGELAEQLEQARR 1242

Query: 343  GSCRMRGGRQAALREVEQIQA-----LEDKKEKEMSAVRLENIQLKQSLVHFETRMRTQE 397
            G       R A   EV +++A        ++E E    RLE +QL++         R + 
Sbjct: 1243 GKGAWEKTRLALEAEVSELRAELSSLQTARQEGEQRRRRLE-LQLQEVQGRAGDGERARA 1301

Query: 398  DLTQGLLLIDFEQLKIENQTFNEKIEERNEELLKLRSKVTNSVQVITHVKEKLHFMDMEN 457
            +  + L     ++ + E +  +  + E   + ++L  +++++   +   +E L       
Sbjct: 1302 EAAEKL-----QRAQAELENVSGALNEAESKTIRLSKELSSTEAQLHDAQELLQEETRAK 1356

Query: 458  ACKKTQLAEIEAQAALGRDILTKTKQARE----GLRTDNIRLN-------QKCGLL--GK 504
                +++  +EA+AA  R+ L +   ARE     L+T   +L+       ++ G L  G+
Sbjct: 1357 LALGSRVRAMEAEAAGLREQLEEEAAARERAGRELQTAQAQLSEWRRRQEEEAGALEAGE 1416

Query: 505  DSLLRDLEEKVDKTELLHRRLESLKR 530
            ++  R   E    T+ L  + E++ R
Sbjct: 1417 EARRRAAREAEALTQRLAEKTETVDR 1442


>gi|116284394 myosin, heavy chain 14 isoform 2 [Homo sapiens]
          Length = 1995

 Score = 64.3 bits (155), Expect = 3e-10
 Identities = 126/562 (22%), Positives = 218/562 (38%), Gaps = 58/562 (10%)

Query: 43   LESEPEEEEEEQAASQGGTAADEQAEAPKGLTAAEAAGEEGPGEPGRPAEPQPEPEEPAE 102
            LE+E  E   E ++ Q      EQ      L   E  G  G GE  R    +      AE
Sbjct: 1246 LEAEVSELRAELSSLQTARQEGEQRRRRLELQLQEVQGRAGDGERARAEAAEKLQRAQAE 1305

Query: 103  VGAEEPAQPEPGAGPEELEAEAGAEE--LEQAAEGKEVRFQASLPL---TRIDEEEAAAA 157
            +     A  E  +    L  E  + E  L  A E  +   +A L L    R  E EAA  
Sbjct: 1306 LENVSGALNEAESKTIRLSKELSSTEAQLHDAQELLQEETRAKLALGSRVRAMEAEAAGL 1365

Query: 158  PEAETERVEGEEEDKEETQRDGAESKE----RDGEGRPAKSQEEGKRLYGRDEFEDL--- 210
             E   E     E    E Q   A+  E    ++ E    ++ EE +R   R E E L   
Sbjct: 1366 REQLEEEAAARERAGRELQTAQAQLSEWRRRQEEEAGALEAGEEARRRAAR-EAEALTQR 1424

Query: 211  --EWSEEVQKLQ--EQQLRSDL------LDQYRSLLVERNRSQR-YNLYLQHKIFEALRR 259
              E +E V +L+   ++L+ +L      L+Q R L+    + QR ++  L  +    LR 
Sbjct: 1425 LAEKTETVDRLERGRRRLQQELDDATMDLEQQRQLVSTLEKKQRKFDQLLAEEKAAVLRA 1484

Query: 260  KKGLEAAEVADRGAEAEAPEKEQAYLRHLGMLEELKKQQADDLQWYHQELGQLKRQCQEK 319
             +  E AE   R  EA A    +A        EEL++Q    L+   + L   K    + 
Sbjct: 1485 VEERERAEAEGREREARALSLTRALEEEQEAREELERQNR-ALRAELEALLSSKDDVGKS 1543

Query: 320  LTRVEKEWRRFQALKKQVVMQAMG-SCRMRGGRQAALREVEQIQALEDKKEKEMS----- 373
            +  +E+  R  +     +  Q       +     A LR    +QAL+ + E+++      
Sbjct: 1544 VHELERACRVAEQAANDLRAQVTELEDELTAAEDAKLRLEVTVQALKTQHERDLQGRDEA 1603

Query: 374  --------AVRLENIQLKQSLVHFETRMRTQEDLTQGLLLIDFEQLKIENQTFNEKIEER 425
                    A +L + ++++     E + RT     +  L  + E+LK +  +  +  EE 
Sbjct: 1604 GEERRRQLAKQLRDAEVERD---EERKQRTLAVAARKKLEGELEELKAQMASAGQGKEEA 1660

Query: 426  NEELLKLRSKVTNSVQVITHVKEKLHFMDMENACKKTQLAEIEAQAALGRDILTKTKQAR 485
             ++L K+++++    + +   +     +  +N   + +L  +EA+    ++ L  + +AR
Sbjct: 1661 VKQLRKMQAQMKELWREVEETRTSREEIFSQNRESEKRLKGLEAEVLRLQEELAASDRAR 1720

Query: 486  EGLRTDNIRLNQKC--GLLGKDSLL--------------RDLEEKVDKTELLHRRLESLK 529
               + D   +  +   G L K ++L               +LEE+   +ELL+ R   L 
Sbjct: 1721 RQAQQDRDEMADEVANGNLSKAAILEEKRQLEGRLGQLEEELEEEQSNSELLNDRYRKLL 1780

Query: 530  RHHASLTLSCRGVRQKIREAKA 551
                SLT      R    +A++
Sbjct: 1781 LQVESLTTELSAERSFSAKAES 1802



 Score = 56.2 bits (134), Expect = 8e-08
 Identities = 108/487 (22%), Positives = 201/487 (41%), Gaps = 69/487 (14%)

Query: 126  AEELEQAAEGKEVRFQASLPLTRIDEEEAAAAPEAETERVEGEEEDKE-ETQRDGAESKE 184
            AE+LEQA  GK    +  L L     E  A     +T R EGE+  +  E Q    + + 
Sbjct: 1226 AEQLEQARRGKGAWEKTRLALEAEVSELRAELSSLQTARQEGEQRRRRLELQLQEVQGRA 1285

Query: 185  RDGEGRPAKSQEEGKR----------LYGRDEFEDLEWSEEV----------QKLQEQQL 224
             DGE   A++ E+ +R               E + +  S+E+          Q+L +++ 
Sbjct: 1286 GDGERARAEAAEKLQRAQAELENVSGALNEAESKTIRLSKELSSTEAQLHDAQELLQEET 1345

Query: 225  RSDLL----------------DQYRSLLVERNRSQRYNLYLQHKIFEALRRKK----GLE 264
            R+ L                 +Q       R R+ R     Q ++ E  RR++     LE
Sbjct: 1346 RAKLALGSRVRAMEAEAAGLREQLEEEAAARERAGRELQTAQAQLSEWRRRQEEEAGALE 1405

Query: 265  AAEVADRGAEAEAPEKEQAYLRHLGMLEELKKQQADDLQWYHQELGQLKRQCQEKLTRVE 324
            A E A R A  EA    Q        ++ L++ +    Q        L++Q ++ ++ +E
Sbjct: 1406 AGEEARRRAAREAEALTQRLAEKTETVDRLERGRRRLQQELDDATMDLEQQ-RQLVSTLE 1464

Query: 325  KEWRRFQAL---KKQVVMQAMGSCRMRG---GRQAALREVEQIQALEDKKEKEMSAVRLE 378
            K+ R+F  L   +K  V++A+   R R    GR+   R +   +ALE+++E      R +
Sbjct: 1465 KKQRKFDQLLAEEKAAVLRAVEE-RERAEAEGREREARALSLTRALEEEQEAREELER-Q 1522

Query: 379  NIQLKQSLVHFETRMRTQEDLTQGLLLIDFEQLKIENQTFNE---KIEERNEEL-----L 430
            N  L+  L   E  + +++D+ + +  ++    ++  Q  N+   ++ E  +EL      
Sbjct: 1523 NRALRAEL---EALLSSKDDVGKSVHELE-RACRVAEQAANDLRAQVTELEDELTAAEDA 1578

Query: 431  KLRSKVTNSVQVITHVKEKLHFMDMENACKKTQLAEIEAQAALGRDILTKTK----QARE 486
            KLR +VT       H ++ L   D     ++ QLA+    A + RD   K +     AR+
Sbjct: 1579 KLRLEVTVQALKTQHERD-LQGRDEAGEERRRQLAKQLRDAEVERDEERKQRTLAVAARK 1637

Query: 487  GL--RTDNIRLNQKCGLLGKDSLLRDLEEKVDKTELLHRRLESLKRHHASLTLSCRGVRQ 544
             L    + ++        GK+  ++ L +   + + L R +E  +     +    R   +
Sbjct: 1638 KLEGELEELKAQMASAGQGKEEAVKQLRKMQAQMKELWREVEETRTSREEIFSQNRESEK 1697

Query: 545  KIREAKA 551
            +++  +A
Sbjct: 1698 RLKGLEA 1704



 Score = 52.8 bits (125), Expect = 8e-07
 Identities = 91/383 (23%), Positives = 161/383 (42%), Gaps = 65/383 (16%)

Query: 46   EPEEEEEEQAASQGGTAADEQAEAPKGLTAAEAAGEEGPGEPGRPAEPQPEPEEPAEVGA 105
            E  EE   Q A Q   A  E+ E  K  T A AA ++  GE           E  A++ +
Sbjct: 1602 EAGEERRRQLAKQLRDAEVERDEERKQRTLAVAARKKLEGEL---------EELKAQMAS 1652

Query: 106  EEPAQPEPGAGPEELEAEAGA--EELEQAAEGKEVRFQASLPLTRIDEEEAAAAPEAETE 163
                + E      +++A+      E+E+    +E  F  +      + E+     EAE  
Sbjct: 1653 AGQGKEEAVKQLRKMQAQMKELWREVEETRTSREEIFSQNR-----ESEKRLKGLEAEVL 1707

Query: 164  RVEGE----EEDKEETQRDGAESKERDGEGRPAKSQ--EEGKRLYGRDEFEDLEWSEEVQ 217
            R++ E    +  + + Q+D  E  +    G  +K+   EE ++L GR     LE     +
Sbjct: 1708 RLQEELAASDRARRQAQQDRDEMADEVANGNLSKAAILEEKRQLEGR--LGQLE-----E 1760

Query: 218  KLQEQQLRSDLL-DQYRSLLV-----------ERNRSQRYNLYLQH--KIFEALRRKKGL 263
            +L+E+Q  S+LL D+YR LL+           ER+ S +     Q   +  + LR + G 
Sbjct: 1761 ELEEEQSNSELLNDRYRKLLLQVESLTTELSAERSFSAKAESGRQQLERQIQELRGRLGE 1820

Query: 264  EAAEVADRGAEAEAPEKEQAYLRHLGMLEELKKQQADDLQWYHQELGQLKRQCQEKLTRV 323
            E     D GA A       A    L   EE  +Q+  +     + + + +++ +E + +V
Sbjct: 1821 E-----DAGARARHKMTIAALESKLAQAEEQLEQETRERILSGKLVRRAEKRLKEVVLQV 1875

Query: 324  EKEWR--------------RFQALKKQVVMQAMGSCRMRGGRQAALREVEQIQALEDKKE 369
            E+E R              R + LK+Q+      + R + GR+   RE+E +    +   
Sbjct: 1876 EEERRVADQLRDQLEKGNLRVKQLKRQLEEAEEEASRAQAGRRRLQRELEDVTESAESMN 1935

Query: 370  KEMSAVRLENIQLKQSLVHFETR 392
            +E++ +R    +L++  + F TR
Sbjct: 1936 REVTTLR---NRLRRGPLTFTTR 1955



 Score = 40.8 bits (94), Expect = 0.003
 Identities = 127/566 (22%), Positives = 218/566 (38%), Gaps = 96/566 (16%)

Query: 39   EPGELESEPEEEEEEQAASQGGTAADEQAEAPKGLTAAEAAGEEGPGEPGRPAEPQPEPE 98
            E GEL+    + EEE+A      A   +AEA     A E  G        R  E +    
Sbjct: 891  EVGELQGRVAQLEEERAR----LAEQLRAEAELCAEAEETRGRLA----ARKQELELVVS 942

Query: 99   E-PAEVGAEEPAQPEPGAGPEEL-----------EAEAGAEELEQ----AAEGKEVRFQA 142
            E  A VG EE    +     + L           EAE GA +  Q      E K  +F+ 
Sbjct: 943  ELEARVGEEEECSRQMQTEKKRLQQHIQELEAHLEAEEGARQKLQLEKVTTEAKMKKFEE 1002

Query: 143  SLPLT----------------RIDEEEAAAAPEAET-----------ERVEGEEED---K 172
             L L                 R+ E  + AA E E            E    + ED   K
Sbjct: 1003 DLLLLEDQNSKLSKERKLLEDRLAEFSSQAAEEEEKVKSLNKLRLKYEATIADMEDRLRK 1062

Query: 173  EETQRDGAESKERDGEGRPAKSQEEGKRLYGRDEFEDLEWSEEVQKLQEQQLRSDLLDQY 232
            EE  R   E  +R  +G  ++ QE+      R E    +   + ++LQ    R++     
Sbjct: 1063 EEKGRQELEKLKRRLDGESSELQEQMVEQQQRAEELRAQLGRKEEELQAALARAEDEGGA 1122

Query: 233  RSLLVERNRSQRYNLYLQHKIFEALRRKKGLEAAEVADRGAEAEAPEKE-QAYLRHLGML 291
            R+ L++  R  +  L    +  E+ R  +     +  D G E EA   E +  L      
Sbjct: 1123 RAQLLKSLREAQAALAEAQEDLESERVARTKAEKQRRDLGEELEALRGELEDTLDSTNAQ 1182

Query: 292  EELKKQQADDLQWYHQELGQLKRQCQEKLTRV------EKEWRRFQA---LKKQVVMQAM 342
            +EL+ ++        QE+ +LK+  +E+ TR+      E   R  QA   L +Q+     
Sbjct: 1183 QELRSKR-------EQEVTELKKTLEEE-TRIHEAAVQELRQRHGQALGELAEQLEQARR 1234

Query: 343  GSCRMRGGRQAALREVEQIQA-----LEDKKEKEMSAVRLENIQLKQSLVHFETRMRTQE 397
            G       R A   EV +++A        ++E E    RLE +QL++         R + 
Sbjct: 1235 GKGAWEKTRLALEAEVSELRAELSSLQTARQEGEQRRRRLE-LQLQEVQGRAGDGERARA 1293

Query: 398  DLTQGLLLIDFEQLKIENQTFNEKIEERNEELLKLRSKVTNSVQVITHVKEKLHFMDMEN 457
            +  + L     ++ + E +  +  + E   + ++L  +++++   +   +E L       
Sbjct: 1294 EAAEKL-----QRAQAELENVSGALNEAESKTIRLSKELSSTEAQLHDAQELLQEETRAK 1348

Query: 458  ACKKTQLAEIEAQAALGRDILTKTKQARE----GLRTDNIRLN-------QKCGLL--GK 504
                +++  +EA+AA  R+ L +   ARE     L+T   +L+       ++ G L  G+
Sbjct: 1349 LALGSRVRAMEAEAAGLREQLEEEAAARERAGRELQTAQAQLSEWRRRQEEEAGALEAGE 1408

Query: 505  DSLLRDLEEKVDKTELLHRRLESLKR 530
            ++  R   E    T+ L  + E++ R
Sbjct: 1409 EARRRAAREAEALTQRLAEKTETVDR 1434


>gi|224831241 myosin, heavy chain 14 isoform 3 [Homo sapiens]
          Length = 2036

 Score = 64.3 bits (155), Expect = 3e-10
 Identities = 126/562 (22%), Positives = 218/562 (38%), Gaps = 58/562 (10%)

Query: 43   LESEPEEEEEEQAASQGGTAADEQAEAPKGLTAAEAAGEEGPGEPGRPAEPQPEPEEPAE 102
            LE+E  E   E ++ Q      EQ      L   E  G  G GE  R    +      AE
Sbjct: 1287 LEAEVSELRAELSSLQTARQEGEQRRRRLELQLQEVQGRAGDGERARAEAAEKLQRAQAE 1346

Query: 103  VGAEEPAQPEPGAGPEELEAEAGAEE--LEQAAEGKEVRFQASLPL---TRIDEEEAAAA 157
            +     A  E  +    L  E  + E  L  A E  +   +A L L    R  E EAA  
Sbjct: 1347 LENVSGALNEAESKTIRLSKELSSTEAQLHDAQELLQEETRAKLALGSRVRAMEAEAAGL 1406

Query: 158  PEAETERVEGEEEDKEETQRDGAESKE----RDGEGRPAKSQEEGKRLYGRDEFEDL--- 210
             E   E     E    E Q   A+  E    ++ E    ++ EE +R   R E E L   
Sbjct: 1407 REQLEEEAAARERAGRELQTAQAQLSEWRRRQEEEAGALEAGEEARRRAAR-EAEALTQR 1465

Query: 211  --EWSEEVQKLQ--EQQLRSDL------LDQYRSLLVERNRSQR-YNLYLQHKIFEALRR 259
              E +E V +L+   ++L+ +L      L+Q R L+    + QR ++  L  +    LR 
Sbjct: 1466 LAEKTETVDRLERGRRRLQQELDDATMDLEQQRQLVSTLEKKQRKFDQLLAEEKAAVLRA 1525

Query: 260  KKGLEAAEVADRGAEAEAPEKEQAYLRHLGMLEELKKQQADDLQWYHQELGQLKRQCQEK 319
             +  E AE   R  EA A    +A        EEL++Q    L+   + L   K    + 
Sbjct: 1526 VEERERAEAEGREREARALSLTRALEEEQEAREELERQNR-ALRAELEALLSSKDDVGKS 1584

Query: 320  LTRVEKEWRRFQALKKQVVMQAMG-SCRMRGGRQAALREVEQIQALEDKKEKEMS----- 373
            +  +E+  R  +     +  Q       +     A LR    +QAL+ + E+++      
Sbjct: 1585 VHELERACRVAEQAANDLRAQVTELEDELTAAEDAKLRLEVTVQALKTQHERDLQGRDEA 1644

Query: 374  --------AVRLENIQLKQSLVHFETRMRTQEDLTQGLLLIDFEQLKIENQTFNEKIEER 425
                    A +L + ++++     E + RT     +  L  + E+LK +  +  +  EE 
Sbjct: 1645 GEERRRQLAKQLRDAEVERD---EERKQRTLAVAARKKLEGELEELKAQMASAGQGKEEA 1701

Query: 426  NEELLKLRSKVTNSVQVITHVKEKLHFMDMENACKKTQLAEIEAQAALGRDILTKTKQAR 485
             ++L K+++++    + +   +     +  +N   + +L  +EA+    ++ L  + +AR
Sbjct: 1702 VKQLRKMQAQMKELWREVEETRTSREEIFSQNRESEKRLKGLEAEVLRLQEELAASDRAR 1761

Query: 486  EGLRTDNIRLNQKC--GLLGKDSLL--------------RDLEEKVDKTELLHRRLESLK 529
               + D   +  +   G L K ++L               +LEE+   +ELL+ R   L 
Sbjct: 1762 RQAQQDRDEMADEVANGNLSKAAILEEKRQLEGRLGQLEEELEEEQSNSELLNDRYRKLL 1821

Query: 530  RHHASLTLSCRGVRQKIREAKA 551
                SLT      R    +A++
Sbjct: 1822 LQVESLTTELSAERSFSAKAES 1843



 Score = 56.2 bits (134), Expect = 8e-08
 Identities = 108/487 (22%), Positives = 201/487 (41%), Gaps = 69/487 (14%)

Query: 126  AEELEQAAEGKEVRFQASLPLTRIDEEEAAAAPEAETERVEGEEEDKE-ETQRDGAESKE 184
            AE+LEQA  GK    +  L L     E  A     +T R EGE+  +  E Q    + + 
Sbjct: 1267 AEQLEQARRGKGAWEKTRLALEAEVSELRAELSSLQTARQEGEQRRRRLELQLQEVQGRA 1326

Query: 185  RDGEGRPAKSQEEGKR----------LYGRDEFEDLEWSEEV----------QKLQEQQL 224
             DGE   A++ E+ +R               E + +  S+E+          Q+L +++ 
Sbjct: 1327 GDGERARAEAAEKLQRAQAELENVSGALNEAESKTIRLSKELSSTEAQLHDAQELLQEET 1386

Query: 225  RSDLL----------------DQYRSLLVERNRSQRYNLYLQHKIFEALRRKK----GLE 264
            R+ L                 +Q       R R+ R     Q ++ E  RR++     LE
Sbjct: 1387 RAKLALGSRVRAMEAEAAGLREQLEEEAAARERAGRELQTAQAQLSEWRRRQEEEAGALE 1446

Query: 265  AAEVADRGAEAEAPEKEQAYLRHLGMLEELKKQQADDLQWYHQELGQLKRQCQEKLTRVE 324
            A E A R A  EA    Q        ++ L++ +    Q        L++Q ++ ++ +E
Sbjct: 1447 AGEEARRRAAREAEALTQRLAEKTETVDRLERGRRRLQQELDDATMDLEQQ-RQLVSTLE 1505

Query: 325  KEWRRFQAL---KKQVVMQAMGSCRMRG---GRQAALREVEQIQALEDKKEKEMSAVRLE 378
            K+ R+F  L   +K  V++A+   R R    GR+   R +   +ALE+++E      R +
Sbjct: 1506 KKQRKFDQLLAEEKAAVLRAVEE-RERAEAEGREREARALSLTRALEEEQEAREELER-Q 1563

Query: 379  NIQLKQSLVHFETRMRTQEDLTQGLLLIDFEQLKIENQTFNE---KIEERNEEL-----L 430
            N  L+  L   E  + +++D+ + +  ++    ++  Q  N+   ++ E  +EL      
Sbjct: 1564 NRALRAEL---EALLSSKDDVGKSVHELE-RACRVAEQAANDLRAQVTELEDELTAAEDA 1619

Query: 431  KLRSKVTNSVQVITHVKEKLHFMDMENACKKTQLAEIEAQAALGRDILTKTK----QARE 486
            KLR +VT       H ++ L   D     ++ QLA+    A + RD   K +     AR+
Sbjct: 1620 KLRLEVTVQALKTQHERD-LQGRDEAGEERRRQLAKQLRDAEVERDEERKQRTLAVAARK 1678

Query: 487  GL--RTDNIRLNQKCGLLGKDSLLRDLEEKVDKTELLHRRLESLKRHHASLTLSCRGVRQ 544
             L    + ++        GK+  ++ L +   + + L R +E  +     +    R   +
Sbjct: 1679 KLEGELEELKAQMASAGQGKEEAVKQLRKMQAQMKELWREVEETRTSREEIFSQNRESEK 1738

Query: 545  KIREAKA 551
            +++  +A
Sbjct: 1739 RLKGLEA 1745



 Score = 52.8 bits (125), Expect = 8e-07
 Identities = 91/383 (23%), Positives = 161/383 (42%), Gaps = 65/383 (16%)

Query: 46   EPEEEEEEQAASQGGTAADEQAEAPKGLTAAEAAGEEGPGEPGRPAEPQPEPEEPAEVGA 105
            E  EE   Q A Q   A  E+ E  K  T A AA ++  GE           E  A++ +
Sbjct: 1643 EAGEERRRQLAKQLRDAEVERDEERKQRTLAVAARKKLEGEL---------EELKAQMAS 1693

Query: 106  EEPAQPEPGAGPEELEAEAGA--EELEQAAEGKEVRFQASLPLTRIDEEEAAAAPEAETE 163
                + E      +++A+      E+E+    +E  F  +      + E+     EAE  
Sbjct: 1694 AGQGKEEAVKQLRKMQAQMKELWREVEETRTSREEIFSQNR-----ESEKRLKGLEAEVL 1748

Query: 164  RVEGE----EEDKEETQRDGAESKERDGEGRPAKSQ--EEGKRLYGRDEFEDLEWSEEVQ 217
            R++ E    +  + + Q+D  E  +    G  +K+   EE ++L GR     LE     +
Sbjct: 1749 RLQEELAASDRARRQAQQDRDEMADEVANGNLSKAAILEEKRQLEGR--LGQLE-----E 1801

Query: 218  KLQEQQLRSDLL-DQYRSLLV-----------ERNRSQRYNLYLQH--KIFEALRRKKGL 263
            +L+E+Q  S+LL D+YR LL+           ER+ S +     Q   +  + LR + G 
Sbjct: 1802 ELEEEQSNSELLNDRYRKLLLQVESLTTELSAERSFSAKAESGRQQLERQIQELRGRLGE 1861

Query: 264  EAAEVADRGAEAEAPEKEQAYLRHLGMLEELKKQQADDLQWYHQELGQLKRQCQEKLTRV 323
            E     D GA A       A    L   EE  +Q+  +     + + + +++ +E + +V
Sbjct: 1862 E-----DAGARARHKMTIAALESKLAQAEEQLEQETRERILSGKLVRRAEKRLKEVVLQV 1916

Query: 324  EKEWR--------------RFQALKKQVVMQAMGSCRMRGGRQAALREVEQIQALEDKKE 369
            E+E R              R + LK+Q+      + R + GR+   RE+E +    +   
Sbjct: 1917 EEERRVADQLRDQLEKGNLRVKQLKRQLEEAEEEASRAQAGRRRLQRELEDVTESAESMN 1976

Query: 370  KEMSAVRLENIQLKQSLVHFETR 392
            +E++ +R    +L++  + F TR
Sbjct: 1977 REVTTLR---NRLRRGPLTFTTR 1996



 Score = 40.8 bits (94), Expect = 0.003
 Identities = 127/566 (22%), Positives = 218/566 (38%), Gaps = 96/566 (16%)

Query: 39   EPGELESEPEEEEEEQAASQGGTAADEQAEAPKGLTAAEAAGEEGPGEPGRPAEPQPEPE 98
            E GEL+    + EEE+A      A   +AEA     A E  G        R  E +    
Sbjct: 932  EVGELQGRVAQLEEERAR----LAEQLRAEAELCAEAEETRGRLA----ARKQELELVVS 983

Query: 99   E-PAEVGAEEPAQPEPGAGPEEL-----------EAEAGAEELEQ----AAEGKEVRFQA 142
            E  A VG EE    +     + L           EAE GA +  Q      E K  +F+ 
Sbjct: 984  ELEARVGEEEECSRQMQTEKKRLQQHIQELEAHLEAEEGARQKLQLEKVTTEAKMKKFEE 1043

Query: 143  SLPLT----------------RIDEEEAAAAPEAET-----------ERVEGEEED---K 172
             L L                 R+ E  + AA E E            E    + ED   K
Sbjct: 1044 DLLLLEDQNSKLSKERKLLEDRLAEFSSQAAEEEEKVKSLNKLRLKYEATIADMEDRLRK 1103

Query: 173  EETQRDGAESKERDGEGRPAKSQEEGKRLYGRDEFEDLEWSEEVQKLQEQQLRSDLLDQY 232
            EE  R   E  +R  +G  ++ QE+      R E    +   + ++LQ    R++     
Sbjct: 1104 EEKGRQELEKLKRRLDGESSELQEQMVEQQQRAEELRAQLGRKEEELQAALARAEDEGGA 1163

Query: 233  RSLLVERNRSQRYNLYLQHKIFEALRRKKGLEAAEVADRGAEAEAPEKE-QAYLRHLGML 291
            R+ L++  R  +  L    +  E+ R  +     +  D G E EA   E +  L      
Sbjct: 1164 RAQLLKSLREAQAALAEAQEDLESERVARTKAEKQRRDLGEELEALRGELEDTLDSTNAQ 1223

Query: 292  EELKKQQADDLQWYHQELGQLKRQCQEKLTRV------EKEWRRFQA---LKKQVVMQAM 342
            +EL+ ++        QE+ +LK+  +E+ TR+      E   R  QA   L +Q+     
Sbjct: 1224 QELRSKR-------EQEVTELKKTLEEE-TRIHEAAVQELRQRHGQALGELAEQLEQARR 1275

Query: 343  GSCRMRGGRQAALREVEQIQA-----LEDKKEKEMSAVRLENIQLKQSLVHFETRMRTQE 397
            G       R A   EV +++A        ++E E    RLE +QL++         R + 
Sbjct: 1276 GKGAWEKTRLALEAEVSELRAELSSLQTARQEGEQRRRRLE-LQLQEVQGRAGDGERARA 1334

Query: 398  DLTQGLLLIDFEQLKIENQTFNEKIEERNEELLKLRSKVTNSVQVITHVKEKLHFMDMEN 457
            +  + L     ++ + E +  +  + E   + ++L  +++++   +   +E L       
Sbjct: 1335 EAAEKL-----QRAQAELENVSGALNEAESKTIRLSKELSSTEAQLHDAQELLQEETRAK 1389

Query: 458  ACKKTQLAEIEAQAALGRDILTKTKQARE----GLRTDNIRLN-------QKCGLL--GK 504
                +++  +EA+AA  R+ L +   ARE     L+T   +L+       ++ G L  G+
Sbjct: 1390 LALGSRVRAMEAEAAGLREQLEEEAAARERAGRELQTAQAQLSEWRRRQEEEAGALEAGE 1449

Query: 505  DSLLRDLEEKVDKTELLHRRLESLKR 530
            ++  R   E    T+ L  + E++ R
Sbjct: 1450 EARRRAAREAEALTQRLAEKTETVDR 1475


>gi|115511012 coiled-coil domain containing 136 [Homo sapiens]
          Length = 1154

 Score = 63.2 bits (152), Expect = 6e-10
 Identities = 127/538 (23%), Positives = 212/538 (39%), Gaps = 75/538 (13%)

Query: 39  EPGELESEPEEEEEEQAASQGGTAADEQAEAPKGLTAAEAAGEEGPGEPGRPAEPQPEPE 98
           E  E E E E EEEE+   +GG+         +GL+  E   EE      +  +   E E
Sbjct: 17  EEEEEEEEEEVEEEEEQVQKGGSVGSLSVNKHRGLSLTETELEE---LRAQVLQLVAELE 73

Query: 99  EPAEVGAEEPAQPEPGAGPEELEAEAGAEELEQAAEGKEVRFQASLPLTRIDEEEAAAAP 158
           E  E+  +         G  E E  A A++ E     K+++ Q    L  + EE +    
Sbjct: 74  ETRELAGQHEDDSLELQGLLEDERLASAQQAEVFT--KQIQ-QLQGELRSLREEISLLEH 130

Query: 159 EAETERVEGEEE-----DKEETQRDGAESKERDGEGRPAKSQEEGKRLYGRDEFEDLEWS 213
           E E+E  E E+E      + ++ R  AE    + E   A  QE+  R+  ++E ED+E  
Sbjct: 131 EKESELKEIEQELHLAQAEIQSLRQAAEDSATEHESDIASLQEDLCRM--QNELEDMERI 188

Query: 214 EEVQKLQEQQLRSDL------------LDQYRSLLVERNRSQRYNLYLQHKIFEALRRKK 261
               +++   LR+++            L  Y S L E  +  R   +  ++ + AL+   
Sbjct: 189 RGDYEMEIASLRAEMEMKSSEPSGSLGLSDY-SGLQEELQELRERYHFLNEEYRALQESN 247

Query: 262 GLEAAEVADRGAE-------------------AEAPEKEQAYLRHLGMLEELKKQQADDL 302
                ++AD  +E                   AE+   E  +L     ++ L++Q  D  
Sbjct: 248 SSLTGQLADLESERTQRATERWLQSQTLSMTSAESQTSEMDFLEPDPEMQLLRQQLRD-- 305

Query: 303 QWYHQELGQLKRQCQEKLTRVEKEWRRFQALKKQVVMQAMGSCRMRGGRQAALREVEQIQ 362
               +++  +K +CQE    +E+     Q  +++         R++   + A  EV + Q
Sbjct: 306 --AEEQMHGMKNKCQELCCELEELQHHRQVSEEE-------QRRLQRELKCAQNEVLRFQ 356

Query: 363 ALEDKKEKEMSAVRLENIQLKQSLVHFETRMRTQEDLTQGLLLIDFE--QLKIENQTFNE 420
                 + E    RL  +Q K     ++T    Q +L +  L +  E  QLK+   T  E
Sbjct: 357 TSHSVTQNEELKSRLCTLQKK-----YDTSQDEQNELLKMQLQLQTELRQLKVMKSTLVE 411

Query: 421 KIEERNEELLKLRSKVTNSVQVITHVKEKLHFMDMENACKKTQLAEIEAQAALGRDILTK 480
              E+  ELL    K+    Q +T  KEKL     +   ++ Q  E E Q    RD +  
Sbjct: 412 NQSEK--ELLCRLQKLHLQHQNVTCEKEKL-LERQQQLQEELQCHEAELQHL--RDTVAS 466

Query: 481 TKQAREGLRTDNIRLNQKCGL--LGKDSLLRDLEEKVDKTE----LLHRRLESLKRHH 532
            K++ E     + +L +   L    KD L R  +   D+ E    L    L+ LK  H
Sbjct: 467 FKESNEKDTETHAQLQEMKQLYQASKDELERQ-KHMYDQLEQDLLLCQLELKELKASH 523



 Score = 36.6 bits (83), Expect = 0.062
 Identities = 28/88 (31%), Positives = 38/88 (43%), Gaps = 5/88 (5%)

Query: 114  GAGPEELEAEAGAEELEQAAEGKEVRFQASLPLTRIDEEEAAAAPEAETERVEGEEEDKE 173
            G   EE + E   EE +Q  E  + +    L     D EEA +     TE  E  EEDKE
Sbjct: 1032 GLAKEEEKKEEMEEEKKQVKEEAKEQCGDELVAEPADPEEAKS-----TEDQEENEEDKE 1086

Query: 174  ETQRDGAESKERDGEGRPAKSQEEGKRL 201
            E +++    +E D      +S EE   L
Sbjct: 1087 EEEKEEDSEEEEDDADSSLESPEENNPL 1114



 Score = 35.4 bits (80), Expect = 0.14
 Identities = 72/350 (20%), Positives = 144/350 (41%), Gaps = 50/350 (14%)

Query: 208 EDLEWSEEVQKLQEQQLRSDLLDQYRSLLVERNRSQRYNLYLQHKIFEALRRK-KGLEAA 266
           E+    E + +LQ+  L+   +   +  L+ER +  +  L       + LR      + +
Sbjct: 411 ENQSEKELLCRLQKLHLQHQNVTCEKEKLLERQQQLQEELQCHEAELQHLRDTVASFKES 470

Query: 267 EVADRGAEAEAPEKEQAYLRHLGMLEELKK---QQADDLQWYHQELGQLK---------- 313
              D    A+  E +Q Y      LE  K    Q   DL     EL +LK          
Sbjct: 471 NEKDTETHAQLQEMKQLYQASKDELERQKHMYDQLEQDLLLCQLELKELKASHPIPEDKG 530

Query: 314 ---RQCQEKLTRVEKEWRRFQALKKQVVMQAMGSCRMRGGRQAALREVEQIQALEDKK-- 368
               +C   L+R+ +   +++A +K+     MG  +M           EQ + LED++  
Sbjct: 531 KCANKCDTLLSRLTELQEKYKASQKE-----MGQLQM-----------EQCELLEDQRRM 574

Query: 369 EKEMSAVRLENIQLKQSLVHFETRMRTQEDLTQGLLLIDFEQLKIENQTFNEKIEERNEE 428
           ++E   ++ E  +L   L      +++QE LT+   L + + L    Q   +K+ +  + 
Sbjct: 575 QEEQGQLQEELHRLTLPLPKSGLLLKSQELLTKLEDLCELQLLYQGMQEEQKKLIQNQDC 634

Query: 429 LLKLRSKVTNSVQVI--THVKEKLHFMD-----MENACKKTQLAEIEAQAALGRDILTKT 481
           +LK + ++   ++    +H +E L   D       + C + + +++  +      ++   
Sbjct: 635 VLKEQLEIHEELRRFKESHFQEVLENPDDSKLAKSSKCNRNKQSKLLMEQMQALQVMYDA 694

Query: 482 KQAREGLRTDNIRLNQKCGLL--GKDSLLRDLEEKVDKTELLHRRLESLK 529
            QA++ L      L Q+ G L   +  L  DL+  +++ +LL  +  S+K
Sbjct: 695 GQAKQEL------LQQEQGRLLEERKRLQADLQLCLEEMQLLQVQSPSIK 738



 Score = 32.0 bits (71), Expect = 1.5
 Identities = 60/272 (22%), Positives = 111/272 (40%), Gaps = 33/272 (12%)

Query: 106  EEPAQPEPGAGPEELEAEAGAEELEQAAEGKEVRFQASLPLTRIDEEEAAAAPEAETERV 165
            EEPA+PE              E  E+      ++ QA   + +I +EE +   E   + +
Sbjct: 838  EEPAEPED------------MERFEEMVVKVLIKLQAVQAMYQISQEEHSQLQEQMEKLL 885

Query: 166  EGEEEDKEETQRDGAESKE-RDGEGRPAKSQEEGKRLYGRDEFEDLEWSEEVQKLQEQQL 224
              +++ KEE      E KE  +   +P   Q +      ++E ++L+      KL+E QL
Sbjct: 886  AKQKDLKEELDACEREFKECMECLEKPMAPQND------KNEIKELQ-----TKLRELQL 934

Query: 225  RSDL-LDQYRSLLVERNRSQRYNLYLQHKIFEALRRKKGLEAAEVADRGAEAEAPEKEQA 283
            +    +D+   LLV + + +      Q ++   LR K+     E   + A      K   
Sbjct: 935  QYQASMDEQGRLLVVQEQLEGQLQCCQEEL-RQLREKRPSVVKEARGKNANKNM-NKNAN 992

Query: 284  YLRHLGMLEELKKQQADDLQWYHQ-ELGQLKRQCQEKLTRVEKEWRRFQAL---KKQVVM 339
             ++   + +        DL+     E+    +  Q KL  + KE  + + +   KKQV  
Sbjct: 993  GVKMKKVTKPCSDTSESDLETRKSLEVVLYYKASQRKLDGLAKEEEKKEEMEEEKKQVKE 1052

Query: 340  QAMGSCRMRGGRQAALREVEQIQALEDKKEKE 371
            +A   C      + A  + E+ ++ ED++E E
Sbjct: 1053 EAKEQCGDELVAEPA--DPEEAKSTEDQEENE 1082


>gi|45439327 periplakin [Homo sapiens]
          Length = 1756

 Score = 62.8 bits (151), Expect = 8e-10
 Identities = 107/551 (19%), Positives = 231/551 (41%), Gaps = 64/551 (11%)

Query: 6    EHTKDPGGEGGDGESLAARPSKIKASSGPPTSPEPGELESEPEEEEEEQAASQGGTAA-- 63
            + T+D G E    E L   P + +A        E   L  +    E E    Q   AA  
Sbjct: 983  QETRDGGQEYVVKEVLRIEPDRAQADEVLQLREELEALRRQKGAREAEVLLLQQRVAALA 1042

Query: 64   DEQAEAPKGLTAAEAAGEEGPGEPGRPAEPQPEPEEPAEVGAEEPAQPEPGAGPEELEAE 123
            +E++ A + +T  E              + Q +P+  AE               ++L+ +
Sbjct: 1043 EEKSRAQEKVTEKEVV------------KLQNDPQLEAEY--------------QQLQED 1076

Query: 124  AGAEELEQAAEGKEVRFQASLPLTRIDEEEAAAAPEAETERVEGEEEDKEETQRDGAESK 183
               ++  +  + +E+ F     L R+++E A A  +   + V   E+D    +     ++
Sbjct: 1077 HQRQDQLREKQEEELSFLQD-KLKRLEKERAMAEGKITVKEVLKVEKDAATEREVSDLTR 1135

Query: 184  ERDGEGRPAKSQEEGKRLYGRDEFEDLEWSEEVQKLQEQQLRSDLLDQYRSLLVERNRSQ 243
            + + E   A++ +           E  E   ++  L+E+  +  + ++ R ++    +++
Sbjct: 1136 QYEDEAAKARASQR----------EKTELLRKIWALEEENAKVVVQEKVREIVRPDPKAE 1185

Query: 244  RYNLYLQHKIFEALRRKKGLEAAEVADRGAEAEAPEKEQAYLRHLGMLEELKKQQADDLQ 303
                 L+ ++ E  R+ +G E  ++    +E EA  +    +    + +E+ K + D   
Sbjct: 1186 SEVANLRLELVEQERKYRGAEE-QLRSYQSELEALRRRGPQVEVKEVTKEVIKYKTDPEM 1244

Query: 304  WYHQELGQLKRQCQEKLTRVEKEWRRFQALKKQVVMQAMGSCRMRGGRQAALREVEQIQA 363
               +EL +L+ +  +K   +E+       LKK++  QA+   + +   +  ++E+ Q Q 
Sbjct: 1245 --EKELQRLREEIVDKTRLIERCDLEIYQLKKEI--QALKDTKPQVQTKEVVQEILQFQE 1300

Query: 364  LEDKKEKEMSAVRLENIQLKQSLVHFETRMRTQED----------------LTQGLLLID 407
                KE E++++R +  + ++  V  E    +QE+                + Q ++  +
Sbjct: 1301 DPQTKE-EVASLRAKLSEEQKKQVDLERERASQEEQIARKEEELSRVKERVVQQEVVRYE 1359

Query: 408  FEQ-LKIENQTFNEKIEERNEELLKLRSKVTNSVQVITHVKEKLHFMDMENACKKTQLAE 466
             E  L+ E   F E I+    ++ KLR+++    +  T ++ +L  ++ E   ++    E
Sbjct: 1360 EEPGLRAEASAFAESIDVELRQIDKLRAELRRLQRRRTELERQLEELERERQARREAERE 1419

Query: 467  IEAQAALGRDILTKTKQAREGL-RTDNIRLNQKCGLLGKDSLLR-DLEEKVDKTELLHRR 524
            ++        +  +  +ARE +  T  + L Q      + +LLR  LEE+  + +LL   
Sbjct: 1420 VQRLQQRLAALEQEEAEAREKVTHTQKVVLQQDPQQAREHALLRLQLEEEQHRRQLLEGE 1479

Query: 525  LESLKRHHASL 535
            LE+L+R  A+L
Sbjct: 1480 LETLRRKLAAL 1490



 Score = 47.8 bits (112), Expect = 3e-05
 Identities = 99/489 (20%), Positives = 197/489 (40%), Gaps = 81/489 (16%)

Query: 110  QPEPGAGPEELEAEAGAEELEQAAEGKEVRFQASLPLTRIDEEEAAAAPEAETERVEGEE 169
            QPE     E L+       +E+A + ++   + +    +++ E  +   E  T R +G +
Sbjct: 870  QPEVEVTHETLQRNRPDSGVEEAWKIRKELDEETERRRQLENEVKSTQEEIWTLRNQGPQ 929

Query: 170  EDKEETQRDGAESKERDGEGRPAKSQEEGKRLYGRDEFEDLEWSEEVQKLQ------EQQ 223
            E          E  ++  +    +S ++ +R    ++ ++    EE++ LQ      EQ+
Sbjct: 930  ESVVRK-----EVLKKVPDPVLEESFQQLQRTLAEEQHKNQLLQEELEALQLQLRALEQE 984

Query: 224  LRSDLLDQY---RSLLVERNRSQRYNLYLQHKIFEALRRKKGLEAAEVADRGAEAEAPEK 280
             R D   +Y     L +E +R+Q   +    +  EALRR+KG   AEV        A  +
Sbjct: 985  TR-DGGQEYVVKEVLRIEPDRAQADEVLQLREELEALRRQKGAREAEVLLLQQRVAALAE 1043

Query: 281  EQAYLRHLGMLEELKKQQAD--------DLQWYHQELGQLKRQ-------CQEKLTRVEK 325
            E++  +     +E+ K Q D         LQ  HQ   QL+ +        Q+KL R+EK
Sbjct: 1044 EKSRAQEKVTEKEVVKLQNDPQLEAEYQQLQEDHQRQDQLREKQEEELSFLQDKLKRLEK 1103

Query: 326  EWRRFQALKKQVVMQAM---------------------GSCRMRGGRQAALREVEQIQAL 364
            E  R  A  K  V + +                      + + R  ++     + +I AL
Sbjct: 1104 E--RAMAEGKITVKEVLKVEKDAATEREVSDLTRQYEDEAAKARASQREKTELLRKIWAL 1161

Query: 365  ED-------------------KKEKEMSAVRLENIQLKQSLVHFETRMRTQEDLTQGLLL 405
            E+                   K E E++ +RLE ++ ++     E ++R+ +   + L  
Sbjct: 1162 EEENAKVVVQEKVREIVRPDPKAESEVANLRLELVEQERKYRGAEEQLRSYQSELEALRR 1221

Query: 406  --IDFEQLKIENQTFNEKIE-ERNEELLKLRSKVTNSVQVITHVKEKLHFMDMENACKKT 462
                 E  ++  +    K + E  +EL +LR ++ +  ++I     +++ +  E    K 
Sbjct: 1222 RGPQVEVKEVTKEVIKYKTDPEMEKELQRLREEIVDKTRLIERCDLEIYQLKKEIQALKD 1281

Query: 463  QLAEIEAQAALGRDILTKTKQAREGLRTDNIRLNQKCGLLGKDSLLRDLE-EKVDKTELL 521
               +++      ++++ +  Q +E  +T     + +  L  +     DLE E+  + E +
Sbjct: 1282 TKPQVQT-----KEVVQEILQFQEDPQTKEEVASLRAKLSEEQKKQVDLERERASQEEQI 1336

Query: 522  HRRLESLKR 530
             R+ E L R
Sbjct: 1337 ARKEEELSR 1345



 Score = 47.4 bits (111), Expect = 4e-05
 Identities = 80/376 (21%), Positives = 158/376 (42%), Gaps = 50/376 (13%)

Query: 118  EELEAEAGAEELEQAAEGKEVRFQASLPLTRIDEEEAAAAPE------------------ 159
            E+L +    E    +   K  R Q+  P T++ EEEAA A +                  
Sbjct: 806  EKLRSLLDLENGRSSHVSKRARLQS--PATKVKEEEAALAAKFTEVYAINRQRLQNLEFA 863

Query: 160  AETERVEGEEEDKEET-QRDGAES-KERDGEGRPAKSQEEGKRLYGRDEFEDLE---WSE 214
                R + E E   ET QR+  +S  E   + R    +E  +R    +E +  +   W+ 
Sbjct: 864  LNLLRQQPEVEVTHETLQRNRPDSGVEEAWKIRKELDEETERRRQLENEVKSTQEEIWTL 923

Query: 215  EVQKLQEQQLRSDLLDQYRSLLVERNRSQRYNLYLQHKIFEALRRKKGLEAAEVADRGAE 274
              Q  QE  +R ++L +    ++E +  Q      + +    L +++ LEA ++  R  E
Sbjct: 924  RNQGPQESVVRKEVLKKVPDPVLEESFQQLQRTLAEEQHKNQLLQEE-LEALQLQLRALE 982

Query: 275  AEAPEKEQAYLRHLGMLEELKKQQADDLQWYHQELGQLKRQ----------CQEKLTRVE 324
             E  +  Q Y+    +  E  + QAD++    +EL  L+RQ           Q+++  + 
Sbjct: 983  QETRDGGQEYVVKEVLRIEPDRAQADEVLQLREELEALRRQKGAREAEVLLLQQRVAALA 1042

Query: 325  KEWRRFQ-ALKKQVVMQAMGSCRMRGGRQAALREVEQIQALEDKKEKEMSAVRLENIQLK 383
            +E  R Q  + ++ V++     ++    Q    + ++   L +K+E+E+S ++    +LK
Sbjct: 1043 EEKSRAQEKVTEKEVVKLQNDPQLEAEYQQLQEDHQRQDQLREKQEEELSFLQ---DKLK 1099

Query: 384  QSLVHFETRMRTQEDLTQGLLLIDFEQLKIENQTFNEK-IEERNEELLKLRSKVTNSVQV 442
                    R+  +  + +G + +  E LK+E     E+ + +   +     +K   S + 
Sbjct: 1100 --------RLEKERAMAEGKITVK-EVLKVEKDAATEREVSDLTRQYEDEAAKARASQRE 1150

Query: 443  ITHVKEKLHFMDMENA 458
             T +  K+  ++ ENA
Sbjct: 1151 KTELLRKIWALEEENA 1166



 Score = 45.4 bits (106), Expect = 1e-04
 Identities = 107/518 (20%), Positives = 214/518 (41%), Gaps = 69/518 (13%)

Query: 28   IKASSGPPTSPEPGELESEPEEEEEEQAASQGGTAADEQAEAPKGLTAAEAAGEEGPGEP 87
            +K      T  E  +L  + E+E  +  ASQ      E+ E  + + A E          
Sbjct: 1118 LKVEKDAATEREVSDLTRQYEDEAAKARASQR-----EKTELLRKIWALE---------- 1162

Query: 88   GRPAEPQPEPEEPAEVGAEEPAQ----PEPGAGPEELEAEAGAEELEQAAEGKEVR---F 140
                      EE A+V  +E  +    P+P A  E         E E+   G E +   +
Sbjct: 1163 ----------EENAKVVVQEKVREIVRPDPKAESEVANLRLELVEQERKYRGAEEQLRSY 1212

Query: 141  QASLPLTRIDEEEAAAAPEAETERVEGEEEDKEETQRDGAESKERDGEGRPAKSQEEGKR 200
            Q+ L   R         P+ E + V  +E  K +T  +  +  +R  E    K+     R
Sbjct: 1213 QSELEALR------RRGPQVEVKEVT-KEVIKYKTDPEMEKELQRLREEIVDKT-----R 1260

Query: 201  LYGRDEFEDLEWSEEVQKLQEQQLRSDLLDQYRSLLV--ERNRSQRYNLYLQHKIFEALR 258
            L  R + E  +  +E+Q L++ + +    +  + +L   E  +++     L+ K+ E  +
Sbjct: 1261 LIERCDLEIYQLKKEIQALKDTKPQVQTKEVVQEILQFQEDPQTKEEVASLRAKLSEEQK 1320

Query: 259  RKKGLEAAEVADRGAEAEAPEKEQAYLRHLGMLEELKKQQADDLQWYHQELGQLKRQCQE 318
            ++  LE  E A +  +    E+E + ++   + +E+ + + +       E          
Sbjct: 1321 KQVDLER-ERASQEEQIARKEEELSRVKERVVQQEVVRYEEEP--GLRAEASAFAESIDV 1377

Query: 319  KLTRVEK---EWRRFQALKKQVVMQAMGSCRMRGGRQAALREVEQIQALEDKKEKEMSAV 375
            +L +++K   E RR Q  + ++  Q     R R  R+ A REV+++Q       + ++A+
Sbjct: 1378 ELRQIDKLRAELRRLQRRRTELERQLEELERERQARREAEREVQRLQ-------QRLAAL 1430

Query: 376  RLENIQLKQSLVHFETRMRTQEDLTQ----GLLLIDFEQLKIENQTFNEKIEERNEELLK 431
              E  + ++ + H + ++  Q+D  Q     LL +  E+ +   Q    ++E    +L  
Sbjct: 1431 EQEEAEAREKVTHTQ-KVVLQQDPQQAREHALLRLQLEEEQHRRQLLEGELETLRRKLAA 1489

Query: 432  L-RSKVTNSVQVITHVKEKLHFMDMENACKKTQLAEIEAQAALGRDILTKTKQAR-EGLR 489
            L +++V   V +   V+ +    + E    K+ L E E+++    D+     +AR   L 
Sbjct: 1490 LEKAEVKEKVVLSESVQVEKGDTEQEIQRLKSSLEE-ESRSKRELDVEVSRLEARLSELE 1548

Query: 490  TDNIRLNQKCGLLGKDSLLRDLEEKVDKTELLHRRLES 527
              N + +++   L +++    LE +    +L  RRL+S
Sbjct: 1549 FHNSKSSKELDFLREENHKLQLERQ--NLQLETRRLQS 1584


>gi|31982906 cingulin-like 1 [Homo sapiens]
          Length = 1302

 Score = 61.6 bits (148), Expect = 2e-09
 Identities = 95/431 (22%), Positives = 188/431 (43%), Gaps = 57/431 (13%)

Query: 123  EAGAEELEQAAEGKEVRFQASLPLTRIDEEEAAAAPEAETERVEGEEEDKEETQRDGAES 182
            EA A+E  +  EG+  + + +L   R +E+EA +A  A    +E  + +  +T ++  + 
Sbjct: 859  EAKAKETLKKYEGEIRQLEEALVHARKEEKEAVSARRALENELEAAQGNLSQTTQEQKQL 918

Query: 183  KERDGEGRPAKSQEEGKRLYGRDEFEDLEWSEEVQKLQEQQL------------RSDLLD 230
             E+  E   ++ +E+ +RL    E E     + ++KLQ++                + LD
Sbjct: 919  SEKLKE--ESEQKEQLRRLKNEMENERWHLGKTIEKLQKEMADIVEASRTSTLELQNQLD 976

Query: 231  QYRSLLVERNRSQRYNLYLQHKIFEALRRKKGLEAAEVAD--RGAEAEAPEKEQAYLRHL 288
            +Y+    E+NR +   +  Q K       K  L A ++ D  R  E E  + ++A    L
Sbjct: 977  EYK----EKNRRELAEMQRQLKEKTLEAEKSRLTAMKMQDEMRLMEEELRDYQRAQDEAL 1032

Query: 289  GMLEELKKQQADDLQWYHQELGQLK-------RQCQEKLTRVEKEWRRFQALKKQVVMQA 341
                +L +Q   DL++  +    LK       +Q ++K++++E E    +  +    + +
Sbjct: 1033 -TKRQLLEQTLKDLEYELEAKSHLKDDRSRLVKQMEDKVSQLEME---LEEERNNSDLLS 1088

Query: 342  MGSCRMRGGRQAALREVEQIQALEDKKEKEMSAVRLENIQLKQSLVHFETRMRTQEDLTQ 401
                R R   +    E+ Q +A     E +  ++  +N  LK  ++H E   R+ +   +
Sbjct: 1089 ERISRSREQMEQLRNELLQERAARQDLECDKISLERQNKDLKSRIIHLEGSYRSSK---E 1145

Query: 402  GLLLIDFEQLKIENQTFNEKI--EERNEELLKLRSKVTNSVQVITHVKEKLHFMDMENAC 459
            GL++    Q++       +++  EER+   L+L ++     ++   VKE +  +D E+  
Sbjct: 1146 GLVV----QMEARIAELEDRLESEERDRANLQLSNR-----RLERKVKELVMQVDDEHLS 1196

Query: 460  KKTQLAEIEAQAALGRDILTKTKQAREGLRTDNIRLNQKCGLLGKDSLLRDLEEKVDKTE 519
               Q  ++  +       L   K+  E    +  RL        K  L R+LEE++D  E
Sbjct: 1197 LTDQKDQLSLR-------LKAMKRQVEEAEEEIDRLES-----SKKKLQRELEEQMDMNE 1244

Query: 520  LLHRRLESLKR 530
             L  +L S+K+
Sbjct: 1245 HLQGQLNSMKK 1255


>gi|4758650 kinesin family member 5C [Homo sapiens]
          Length = 957

 Score = 60.8 bits (146), Expect = 3e-09
 Identities = 88/426 (20%), Positives = 181/426 (42%), Gaps = 44/426 (10%)

Query: 119 ELEAEAGAEELEQAAEGKEVRFQASLPLTRIDEEEAAAAPEAETERVEGEEEDKEETQRD 178
           ++E EA  +E+++  +  E     +      + E+   A E  T+ +  +      TQR+
Sbjct: 474 QIENEAAKDEVKEVLQALE-ELAVNYDQKSQEVEDKTRANEQLTDELAQKTTTLTTTQRE 532

Query: 179 GAESKERDGEGRPAKSQEEGKRLYGRDEFEDLEWSEEVQKLQEQQLRSDLLDQYRSLLVE 238
            ++ +E     +   ++     L    E   +  + +V+ L +    + ++++      E
Sbjct: 533 LSQLQELSNHQKKRATEILNLLLKDLGEIGGIIGTNDVKTLADV---NGVIEE------E 583

Query: 239 RNRSQRYNLYLQHKIFEALRRKKGLEAAEVADRGAEAEAPEKEQAYLRHLGMLEELKKQQ 298
              ++ Y   ++ ++   + R K LE+A++ D   +  A E+E A  + L    E K + 
Sbjct: 584 FTMARLYISKMKSEVKSLVNRSKQLESAQM-DSNRKMNASERELAACQLLISQHEAKIKS 642

Query: 299 ADDLQWYHQELGQLKRQCQEKLTRVEKEWRRFQALKKQVVMQAMGS-----CRMRGGRQA 353
             D   Y Q + Q +RQ +E    + +E  + +A +K   +           R++   + 
Sbjct: 643 LTD---YMQNMEQKRRQLEESQDSLSEELAKLRAQEKMHEVSFQDKEKEHLTRLQDAEEM 699

Query: 354 ALREVEQIQALEDKKEKEMSAVRLENIQLKQSLVHFETRMRTQEDLTQGLLLIDFEQLKI 413
                +Q+++  +  +K++S +R + I+ KQ ++     +  +  L Q  L  D+ +LKI
Sbjct: 700 KKALEQQMESHREAHQKQLSRLR-DEIEEKQKIIDEIRDLNQKLQLEQEKLSSDYNKLKI 758

Query: 414 ENQ----------TFNEKIEERNEELLKLRSKVTNSVQVITHVKEKLHFMDMENACKKT- 462
           E+Q            N+K E+  E+L  L   V+  +Q + H   KL   D+    KK+ 
Sbjct: 759 EDQEREMKLEKLLLLNDKREQAREDLKGLEETVSRELQTL-HNLRKLFVQDLTTRVKKSV 817

Query: 463 ---------QLAEIEAQAALGRDILTKTKQAREGLRTDNIRLNQKCGLLGKDSLLRDLEE 513
                      A+ +  + L  ++   TK  ++ +R DN  L  +C L   +  LR   E
Sbjct: 818 ELDNDDGGGSAAQKQKISFLENNLEQLTKVHKQLVR-DNADL--RCELPKLEKRLRATAE 874

Query: 514 KVDKTE 519
           +V   E
Sbjct: 875 RVKALE 880


>gi|71361682 nuclear mitotic apparatus protein 1 [Homo sapiens]
          Length = 2115

 Score = 59.7 bits (143), Expect = 7e-09
 Identities = 138/593 (23%), Positives = 238/593 (40%), Gaps = 105/593 (17%)

Query: 19   ESLAARPSKIKASSGPPTSPEPGEL-ESEPEEEEEEQAASQGGTAADEQAEAPKGLTAAE 77
            E+L  +  + + ++      EP    + +PE  EE+Q      T A  QA   +    AE
Sbjct: 920  ETLVRKAGEQQETASRELVKEPARAGDRQPEWLEEQQGRQFCSTQAALQAMERE----AE 975

Query: 78   AAGEEGPGEPGRPAEPQPEPEEPAEVGAEEPAQ--PEPGAGPEELEAEAGAE-----ELE 130
              G E         E Q + +E       E A+   E G    +L  E  A       L+
Sbjct: 976  QMGNELERLRAALMESQGQQQEERGQQEREVARLTQERGRAQADLALEKAARAELEMRLQ 1035

Query: 131  QAAEGKEVRF---QASLPLTRIDEE----EAAAAPEAETERVEGEEEDKE---ETQRDGA 180
             A   + V F   Q +L     ++E    E A     E  +++  EE ++   + +   A
Sbjct: 1036 NALNEQRVEFATLQEALAHALTEKEGKDQELAKLRGLEAAQIKELEELRQTVKQLKEQLA 1095

Query: 181  ESKERDGEGRPAKSQEEGKRLYGRDEFEDL--EWSEEVQKLQEQQLRSDLLDQYRSLLVE 238
            + ++    G  A+S+  G+      + E L  E S+  Q+ Q+QQ ++D L+  RSL  E
Sbjct: 1096 KKEKEHASGSGAQSEAAGRTEPTGPKLEALRAEVSKLEQQCQKQQEQADSLE--RSLEAE 1153

Query: 239  R-NRSQRYNLYLQHKIFEALRRKKGLEAAEVADRGAEAEAPEKEQAYLR-----HLGMLE 292
            R +R++R          E L+ +   +A E+    +   + ++E A  R     H    +
Sbjct: 1154 RASRAER------DSALETLQGQLEEKAQELGHSQSALASAQRELAAFRTKVQDHSKAED 1207

Query: 293  ELKKQQADDLQW----------YHQELGQLKRQCQEK-----------LTRVEKEWRRFQ 331
            E K Q A   Q             +E+  L RQ  EK           +   EK  +  +
Sbjct: 1208 EWKAQVARGRQEAERKNSLISSLEEEVSILNRQVLEKEGESKELKRLVMAESEKSQKLEE 1267

Query: 332  ALKKQVVMQAMGSCRMRGGRQAALREVEQIQALEDKKEKEMSAVRLENIQLKQSLVHFET 391
             L+      A  S R    R +ALRE  ++Q+L ++ EK+    R+ +  L+Q L     
Sbjct: 1268 RLRLLQAETASNSARA-AERSSALRE--EVQSLREEAEKQ----RVASENLRQELTSQAE 1320

Query: 392  RMRTQEDLTQGLLLIDFEQLKIENQTFNEKIEERNEELLKLRSKVTNSVQVITHVKEKLH 451
            R                E+L  E + + EK  ++ + L  L+ + T++  +++ +    H
Sbjct: 1321 RA---------------EELGQELKAWQEKFFQKEQALSTLQLEHTSTQALVSELLPAKH 1365

Query: 452  FMDMENACKKTQLAEIEAQAALGRDILTKTKQAREGLRTDNIRLNQKCGLLGKDSLLRDL 511
                   C++ Q AE  A     R+ L ++KQA  GLR + +R  ++ G       L  L
Sbjct: 1366 L------CQQLQ-AEQAAAEKRHREELEQSKQAAGGLRAELLRAQRELG------ELIPL 1412

Query: 512  EEKVDKTELLHRRLES-----------LKRHHASLTLSCRGVRQKIREAKAFL 553
             +KV + E   ++L +           LK+ H  L    RG+ ++    + FL
Sbjct: 1413 RQKVAEQERTAQQLRAEKASYAEQLSMLKKAHGLLAEENRGLGERANLGRQFL 1465



 Score = 59.3 bits (142), Expect = 9e-09
 Identities = 105/502 (20%), Positives = 207/502 (41%), Gaps = 59/502 (11%)

Query: 43   LESEPEEEEEEQ---AASQGGTAADEQAEAPKGLTAAEAAGEEGPGEPGRPAEPQPEPEE 99
            LE E E +E ++   A S+     +E+    +  TA+ +A         R AE      E
Sbjct: 1242 LEKEGESKELKRLVMAESEKSQKLEERLRLLQAETASNSA---------RAAERSSALRE 1292

Query: 100  PAEVGAEEPAQPEPGAGP--EELEAEAG-AEELEQAAEG-KEVRFQASLPLTRIDEEEAA 155
              +   EE  +    +    +EL ++A  AEEL Q  +  +E  FQ    L+ +  E  +
Sbjct: 1293 EVQSLREEAEKQRVASENLRQELTSQAERAEELGQELKAWQEKFFQKEQALSTLQLEHTS 1352

Query: 156  AAPEAET--------ERVEGEEEDKEETQRDGAESKERDGEGRPAKSQEEGKRLYGRDEF 207
                           ++++ E+   E+  R+  E  ++   G  A+     + L    E 
Sbjct: 1353 TQALVSELLPAKHLCQQLQAEQAAAEKRHREELEQSKQAAGGLRAELLRAQREL---GEL 1409

Query: 208  EDLEWSEEVQKLQEQQLRSD---------LLDQYRSLLVERNRS--QRYNL---YLQHKI 253
              L      Q+   QQLR++         +L +   LL E NR   +R NL   +L+ ++
Sbjct: 1410 IPLRQKVAEQERTAQQLRAEKASYAEQLSMLKKAHGLLAEENRGLGERANLGRQFLEVEL 1469

Query: 254  FEALRRKKGLEAAEVADRGAE-AEAPEKEQAYLRHLGML----EELKKQQADDLQWYHQE 308
             +A  +     AA  AD     AE   + Q+  R L ++    E  K +  ++ Q + +E
Sbjct: 1470 DQAREKYVQELAAVRADAETRLAEVQREAQSTARELEVMTAKYEGAKVKVLEERQRFQEE 1529

Query: 309  LGQLKRQCQEKLTRVEKEWRRFQALKKQ---------VVMQAMGSCRMRGG--RQAALRE 357
              +L  Q ++      ++ ++ + L K+         V  Q + + + +GG  +Q A R 
Sbjct: 1530 RQKLTAQVEQLEVFQREQTKQVEELSKKLADSDQASKVQQQKLKAVQAQGGESQQEAQRL 1589

Query: 358  VEQIQALEDKKEKEMSAVRLENIQLKQSLVHFETRMRTQEDLTQGLLLIDFEQLKIENQT 417
              Q+  L+ +  ++  A     +Q++++  H++ + +  ++L + L  +  EQL+ EN+ 
Sbjct: 1590 QAQLNELQAQLSQKEQAAEHYKLQMEKAKTHYDAKKQQNQELQEQLRSL--EQLQKENKE 1647

Query: 418  FNEKIEERNEELLKLRSKVTNSVQVITHVKEKLHFMDMENACKKTQLAEIEAQAALGRDI 477
               + E    EL +   K   + Q   H+  ++  ++ + A    QL ++         +
Sbjct: 1648 LRAEAERLGHELQQAGLKTKEAEQTCRHLTAQVRSLEAQVAHADQQLRDLGKFQVATDAL 1707

Query: 478  LTKTKQAREGLRTDNIRLNQKC 499
             ++  QA+  L      L+  C
Sbjct: 1708 KSREPQAKPQLDLSIDSLDLSC 1729



 Score = 51.6 bits (122), Expect = 2e-06
 Identities = 88/404 (21%), Positives = 174/404 (43%), Gaps = 39/404 (9%)

Query: 129 LEQAAEGKEVRFQASLPLTRIDEEEAAAAPEAETERVEGEEEDKEETQRDGAESKE--RD 186
           L+Q A+ K    QA L  T   +E+A+     + E++    + KE+  ++ AE +E  R 
Sbjct: 524 LKQQAKEK----QAQLAQTLQQQEQASQGLRHQVEQLSSSLKQKEQQLKEVAEKQEATRQ 579

Query: 187 GEGRPAKSQEEGKRLYGRDEFEDLEWSEEVQKLQEQQLRSDLLDQYRSLLVE-RNRSQRY 245
              +   +  E +    R+    L+  E ++K  E+  + ++L Q   +  E R+ +Q  
Sbjct: 580 DHAQQLATAAEEREASLRERDAALKQLEALEK--EKAAKLEILQQQLQVANEARDSAQTS 637

Query: 246 NLYLQHKIFEALRRKKGLEAAEVADRGAEAEAPEKEQAYLRHLGMLEELKKQQADDLQWY 305
               Q +  E  R+ + L+A     R  + EA    QA +  L +    ++Q+A + +  
Sbjct: 638 VTQAQREKAELSRKVEELQACVETARQEQHEA----QAQVAELELQLRSEQQKATEKERV 693

Query: 306 HQELGQLKRQCQE-----KLTR--VEKEWRR-FQALKKQVVMQAMGSCRMRGGRQAALRE 357
            QE  QL+ Q Q      K+T+  +E+E RR   AL++Q    +      R   +   RE
Sbjct: 694 AQEKDQLQEQLQALKESLKVTKGSLEEEKRRAADALEEQQRCISELKAETRSLVEQHKRE 753

Query: 358 VEQIQALEDKKEKEMSAVRLENI-QLKQSLVHFETRMRTQEDLTQGLLLIDFEQLKIENQ 416
            ++++  E++  ++    RL+ + +  Q+      R   +    Q     + EQL  E  
Sbjct: 754 RKELE--EERAGRKGLEARLQQLGEAHQAETEVLRRELAEAMAAQHTAESECEQLVKEVA 811

Query: 417 TFNEKIEER-----------NEELLKLRSKVTNSVQVITHVKEKL----HFMDMENACKK 461
            + E+ E+             E+L+ L+ +   + Q +   KEK+       +++ + ++
Sbjct: 812 AWRERYEDSQQEEAQYGAMFQEQLMTLKEECEKARQELQEAKEKVAGIESHSELQISRQQ 871

Query: 462 TQLAEIEAQAALGRDILTKTKQAREGLRTDNIRLNQKCGLLGKD 505
            +LAE+ A  A     + + +   + L  D   L +K     K+
Sbjct: 872 NELAELHANLARALQQVQEKEVRAQKLADDLSTLQEKMAATSKE 915



 Score = 33.1 bits (74), Expect = 0.68
 Identities = 111/567 (19%), Positives = 220/567 (38%), Gaps = 64/567 (11%)

Query: 19  ESLAARPSKIKASSGPPTSPEPGELESEPEEEE---EEQAASQGGTAAD---EQAEAPKG 72
           + +A+  S     SG P SP  G++   P+ +    ++Q A +     +   E AE  K 
Sbjct: 185 QKVASSSSGNNFLSGSPASPM-GDILQTPQFQMRRLKKQLADERSNRDELELELAENRKL 243

Query: 73  LTAAEAAGEEGPGEPGRPAEPQPEPEEPAEVGAEEPAQPEPGAGPEELEAEAGA------ 126
           LT  +A          + A  Q   +  A +  ++ A P      EEL  +  +      
Sbjct: 244 LTEKDA----------QIAMMQQRIDRLALLNEKQAASPLEPKELEELRDKNESLTMRLH 293

Query: 127 EELEQAAEGKEVRFQASLPLTRIDEEE----------AAAAPEAETERVEGEEEDKEETQ 176
           E L+Q  + K  + Q    + ++ EE           A+   + +    E  EE  + TQ
Sbjct: 294 ETLKQCQDLKTEKSQMDRKINQLSEENGDLSFKLREFASHLQQLQDALNELTEEHSKATQ 353

Query: 177 ----RDGAESKERDGEGRPAKSQEEGKRLYGRDEFEDLEWSEEVQKLQEQ------QLRS 226
               +     KE     +  K  EE   +  + +   LE  E + +LQ+       ++  
Sbjct: 354 EWLEKQAQLEKELSAALQDKKCLEEKNEIL-QGKLSQLE--EHLSQLQDNPPQEKGEVLG 410

Query: 227 DLLDQYRSLLVERNRSQRYNLYLQHKIFEALRRKKGLEAAEV-ADRGAEAEAPEKEQAYL 285
           D+L Q  +L  E       N  LQ ++ E L  ++G + A++ A+RG   E  EK+Q   
Sbjct: 411 DVL-QLETLKQEAATLAANNTQLQARV-EMLETERGQQEAKLLAERGHFEE--EKQQ--- 463

Query: 286 RHLGMLEELKKQQADDLQWYHQELGQLKRQCQEKLT-RVEKEWRRFQALKKQVVMQAMGS 344
             L  L    +    +L    +EL Q  +    +LT +V         L   +  Q    
Sbjct: 464 --LSSLITDLQSSISNLSQAKEELEQASQAHGARLTAQVASLTSELTTLNATIQQQDQ-- 519

Query: 345 CRMRGGRQAALREVEQIQALEDKKEKEMSAVRLENIQLKQSLVHFETRMRTQEDLTQGLL 404
             + G +Q A  +  Q+     ++E+    +R +  QL  SL   E +++   +  +   
Sbjct: 520 -ELAGLKQQAKEKQAQLAQTLQQQEQASQGLRHQVEQLSSSLKQKEQQLKEVAEKQEATR 578

Query: 405 LIDFEQLKIENQTFNEKIEERNEELLKLRSKVTNSVQVITHVKEKLHFMDMENACKKTQL 464
               +QL    +     + ER+  L +L +        +  ++++L   +      +T +
Sbjct: 579 QDHAQQLATAAEEREASLRERDAALKQLEALEKEKAAKLEILQQQLQVANEARDSAQTSV 638

Query: 465 AEIEAQAALGRDILTKTKQAREGLRTDNIRLNQKCGLLGKDSL-LRDLEEKVDKTELLHR 523
            + + + A   ++  K ++ +  + T     ++    + +  L LR  ++K  + E + +
Sbjct: 639 TQAQREKA---ELSRKVEELQACVETARQEQHEAQAQVAELELQLRSEQQKATEKERVAQ 695

Query: 524 RLESLKRHHASLTLSCRGVRQKIREAK 550
             + L+    +L  S +  +  + E K
Sbjct: 696 EKDQLQEQLQALKESLKVTKGSLEEEK 722


>gi|21735548 centrosomal protein 2 [Homo sapiens]
          Length = 2442

 Score = 59.3 bits (142), Expect = 9e-09
 Identities = 98/454 (21%), Positives = 195/454 (42%), Gaps = 64/454 (14%)

Query: 124  AGAEELEQAAEGKEVRFQASLPLTRIDEEEAAAAPEAETERVEGEEEDKEETQRDGAESK 183
            A AE+  +A   K    +A L       EEA A  +A+   ++   E+KEE Q+  +ES+
Sbjct: 648  AEAEKRREALWEKNTHLEAQLQKA----EEAGAELQADLRDIQ---EEKEEIQKKLSESR 700

Query: 184  ERDGEG--------RPAKSQEE--GKRLYGRDEFEDLEWSEEVQKLQEQQLRSDLLDQYR 233
             +            + AK QEE   + +  ++     + + EV+    ++ R DL +Q +
Sbjct: 701  HQQEAATTQLEQLHQEAKRQEEVLARAVQEKEALVREKAALEVRLQAVERDRQDLAEQLQ 760

Query: 234  SLLVERNRSQRYNLYLQHKIFEALRRKKGLEAAE---VADRGAEAEAPEKEQAYLRHLGM 290
             L   +         L+  +FEA ++   +E  +           +A E  Q  +R L +
Sbjct: 761  GLSSAKE-------LLESSLFEAQQQNSVIEVTKGQLEVQIQTVTQAKEVIQGEVRCLKL 813

Query: 291  LEELKKQQADDLQWYHQELGQLKRQCQEKLTRVEKEWRRFQALKKQVVMQAMGSCRMRGG 350
              + ++ QA+      QE     RQ    L + E+E +     +K    + +   R +  
Sbjct: 814  ELDTERSQAE------QERDAAARQ----LAQAEQEGKTALEQQKAAHEKEVNQLREKWE 863

Query: 351  RQAALREVEQIQALEDKKEKEMSAVRLENIQLKQSLVHFET-RMRTQEDLTQGLLLIDFE 409
            ++ +  + E  +ALE  + ++M       ++LK+     E  + + +E+ TQ    +   
Sbjct: 864  KERSWHQQELAKALESLEREKMEL----EMRLKEQQTEMEAIQAQREEERTQAESALCQM 919

Query: 410  QLKIENQTFNEKIEERNEELLKLRSKVTNSVQVITHVKEKLHFMDMEN----ACKKTQLA 465
            QL+ E +  +       E LL+ + ++ ++ Q +  +++ +    ++        +TQL 
Sbjct: 920  QLETEKERVSLL-----ETLLQTQKELADASQQLERLRQDMKVQKLKEQETTGILQTQLQ 974

Query: 466  EIEAQ----AALGRDILTKTKQAREGLRTDNIRLNQ-----KCGLLGKDSLLR----DLE 512
            E + +    A   RD L   ++    L  D + L +     K  L+ +D   R    +++
Sbjct: 975  EAQRELKEAARQHRDDLAALQEESSSLLQDKMDLQKQVEDLKSQLVAQDDSQRLVEQEVQ 1034

Query: 513  EKVDKTELLHRRLESLKRHHASLTLSCRGVRQKI 546
            EK+ +T+  +R  + L+R  ASLTLS     Q++
Sbjct: 1035 EKLRETQEYNRIQKELEREKASLTLSLMEKEQRL 1068



 Score = 54.3 bits (129), Expect = 3e-07
 Identities = 108/568 (19%), Positives = 228/568 (40%), Gaps = 69/568 (12%)

Query: 43   LESEPEEEEEEQAASQGGTAADEQAEAPKGLTAAEAA-GEEGPGEP----GRPAEPQPEP 97
            L S   + E   A  Q G  A  QA+     +A + A G      P    G  + P    
Sbjct: 1156 LRSTESQLEALAAEQQPGNQAQAQAQLASLYSALQQALGSVCESRPELSGGGDSAPSVWG 1215

Query: 98   EEPAEVGAEEPAQPEPGAGPEELEAEAGA-----EELEQAAEGKEVRFQASLPLTRIDEE 152
             EP + GA    +  P       EA A A     ++L +  + ++V       L     E
Sbjct: 1216 LEPDQNGARSLFKRGPLLTALSAEAVASALHKLHQDLWKTQQTRDVLRDQVQKL-----E 1270

Query: 153  EAAAAPEAETERVEGEEEDKEETQRDGAESKERDGEGRPAKSQEEGKRLYG--------- 203
            E     EAE  +V  E +D +       E K +  EG+    + E   L+          
Sbjct: 1271 ERLTDTEAEKSQVHTELQDLQRQLSQNQEEKSK-WEGKQNSLESELMELHETMASLQSRL 1329

Query: 204  -RDEFEDLEWSEEVQKLQEQQLRSDLLDQYRSLLVERNRSQRYNLYLQHKIFEALRRKKG 262
             R E + +E   E + LQ  +       ++    V   R+Q     +  +     R    
Sbjct: 1330 RRAELQRMEAQGERELLQAAKENLTAQVEHLQAAVVEARAQASAAGILEEDLRTARSALK 1389

Query: 263  LEAAEVADRGAEAEAPEKE--------QAYLRHLGMLEELKKQQADDLQWYHQELGQLKR 314
            L+  EV      A+A +++        +A   +L +L +   ++ ++++    ++ +L++
Sbjct: 1390 LKNEEVESERERAQALQEQGELKVAQGKALQENLALLTQTLAEREEEVETLRGQIQELEK 1449

Query: 315  QCQEK-----LTRVEKEWRRFQALKKQVVMQAMGSCR---------MRGGRQAALREVEQ 360
            Q + +     L  ++ + R  +   +Q  +Q +  CR         ++   Q    + EQ
Sbjct: 1450 QREMQKAALELLSLDLKKRNQEVDLQQEQIQELEKCRSVLEHLPMAVQEREQKLTVQREQ 1509

Query: 361  IQALEDKKEKEMSAVRLENIQLKQSLVHFETRMRTQEDLTQGLLLIDFEQLKIENQTFNE 420
            I+ LE  +E + + +  + ++L++     E++    +DL + L+ ++   L++E    + 
Sbjct: 1510 IRELEKDRETQRNVLEHQLLELEKKDQMIESQRGQVQDLKKQLVTLECLALELEEN--HH 1567

Query: 421  KIEERNEELLKLRSKVTNSVQVITHVKEKLHFMDMENACKKTQLAEIEAQAAL------- 473
            K+E + + + +L  +       +TH+   L     E   + +Q+ ++E+ + +       
Sbjct: 1568 KMECQQKLIKELEGQRETQRVALTHLTLDLEERSQELQAQSSQIHDLESHSTVLARELQE 1627

Query: 474  -------GRDILTKTKQAREGLRTDNIRLNQKCGLLGKDSLLRDLEEKVDKTELLHRRLE 526
                    R+ + + ++ +E L  D  R +Q+  +L K+ +    +++  +T++L   LE
Sbjct: 1628 RDQEVKSQREQIEELQRQKEHLTQDLERRDQEL-MLQKERIQVLEDQRTRQTKILEEDLE 1686

Query: 527  ----SLKRHHASLTLSCRGVRQKIREAK 550
                SL+     LT   + ++++  E K
Sbjct: 1687 QIKLSLRERGRELTTQRQLMQERAEEGK 1714



 Score = 53.9 bits (128), Expect = 4e-07
 Identities = 111/481 (23%), Positives = 189/481 (39%), Gaps = 93/481 (19%)

Query: 121  EAEAGAEELEQAAEGKEVRFQASLPLTRIDEE------EAAAAPEAETERVEGEEEDKEE 174
            E ++  E++E+    KE   Q    L R D+E            +  T + +  EED E+
Sbjct: 1631 EVKSQREQIEELQRQKEHLTQ---DLERRDQELMLQKERIQVLEDQRTRQTKILEEDLEQ 1687

Query: 175  -------------TQRDGAESKERDGEGRPAKSQE---EGKRLYGRDEFEDLEWSEE-VQ 217
                         TQR   + +  +G+G P+K+Q    E  +L  RD+ +++E  +E + 
Sbjct: 1688 IKLSLRERGRELTTQRQLMQERAEEGKG-PSKAQRGSLEHMKLILRDKEKEVECQQEHIH 1746

Query: 218  KLQE--QQLRSDLLDQYRSL----LVERNRSQRYNLYLQHKIFEALRR--------KKGL 263
            +LQE   QL   L   +R +    L+   R Q   + LQ ++ EA  +        +  L
Sbjct: 1747 ELQELKDQLEQQLQGLHRKVGETSLLLSQREQEI-VVLQQQLQEAREQGELKEQSLQSQL 1805

Query: 264  EAAE--VADRGAEAEAPEKEQAYLRHLGMLEELKKQQADDLQWY-----------HQELG 310
            + A+  +A R  E EA ++EQ   +     EE  K++AD LQ             H EL 
Sbjct: 1806 DEAQRALAQRDQELEALQQEQQQAQGQ---EERVKEKADALQGALEQAHMTLKERHGELQ 1862

Query: 311  QLKRQCQEKLTRVEKEWRRFQALKKQVVMQAMGSCRMRGGRQAALREVEQIQALEDKKEK 370
              K Q +     +  E RR QAL+     + +G  R     Q       Q Q  E  +E 
Sbjct: 1863 DHKEQARRLEEELAVEGRRVQALE-----EVLGDLRAESREQEKALLALQQQCAEQAQEH 1917

Query: 371  EMSAVRLENIQLKQSLVHFETRMRTQEDLTQGLLLIDFEQLKIENQTFNEKIEERNEELL 430
            E+    L++  L+   V    + R QE           E L+ E+Q+         EE  
Sbjct: 1918 EVETRALQDSWLQAQAV---LKERDQE----------LEALRAESQS-----SRHQEEAA 1959

Query: 431  KLRSKVTNSVQVITHVK---EKLHFMDMENACKKTQLAEIEAQAALGRDILTKTKQAREG 487
            + R++         H     ++ H ++     +  + +    QA+L       ++Q  E 
Sbjct: 1960 RARAEALQEALGKAHAALQGKEQHLLEQAELSRSLEASTATLQASLDA-CQAHSRQLEEA 2018

Query: 488  LRTDNIRLNQKCGLLGKDSLLRDLEEKVDKTELLHRRLESLKRHHASLTLSCRGVRQKIR 547
            LR     +        +D  LR  E+     + L +R E L+       L  + + Q+++
Sbjct: 2019 LRIQEGEI--------QDQDLRYQEDVQQLQQALAQRDEELRHQQEREQLLEKSLAQRVQ 2070

Query: 548  E 548
            E
Sbjct: 2071 E 2071



 Score = 50.8 bits (120), Expect = 3e-06
 Identities = 74/361 (20%), Positives = 157/361 (43%), Gaps = 47/361 (13%)

Query: 119  ELEAEAGAEELEQAAEGKEVRFQASLPLTRIDEEEAAAAPEAETERVEGE---EEDKEET 175
            +++    A+E+ Q  E + ++ +     ++ ++E  AAA +      EG+   E+ K   
Sbjct: 793  QIQTVTQAKEVIQG-EVRCLKLELDTERSQAEQERDAAARQLAQAEQEGKTALEQQKAAH 851

Query: 176  QRDGAESKERDGEGRPAKSQEEGKRLYGRDEFEDLEWSEEVQKLQEQQLRSDLLDQYRSL 235
            +++  + +E+  + R    QE  K L    E  + E  E   +L+EQQ   + +   R  
Sbjct: 852  EKEVNQLREKWEKERSWHQQELAKAL----ESLEREKMELEMRLKEQQTEMEAIQAQR-- 905

Query: 236  LVERNRSQRYNLYLQHKIFEALRRKKGLEAA-----EVADRGAEAEAPEKEQAYLRHLGM 290
              E  R+Q  +   Q ++     R   LE       E+AD   + E        LR    
Sbjct: 906  --EEERTQAESALCQMQLETEKERVSLLETLLQTQKELADASQQLER-------LRQDMK 956

Query: 291  LEELKKQQAD-----DLQWYHQELGQLKRQCQEKLTRVEKE-----------WRRFQALK 334
            +++LK+Q+        LQ   +EL +  RQ ++ L  +++E            ++ + LK
Sbjct: 957  VQKLKEQETTGILQTQLQEAQRELKEAARQHRDDLAALQEESSSLLQDKMDLQKQVEDLK 1016

Query: 335  KQVVMQAMGSCRMRGGRQAALREVEQIQALEDKKEKEMSAVRLENIQLKQSLVHFE---- 390
             Q+V Q      +    Q  LRE ++   ++ + E+E +++ L  ++ +Q L+  +    
Sbjct: 1017 SQLVAQDDSQRLVEQEVQEKLRETQEYNRIQKELEREKASLTLSLMEKEQRLLVLQEADS 1076

Query: 391  TRMRTQEDLTQGLLLIDFEQ--LKIENQTFNEKIEERNEELLKLRSKVTNSVQVITHVKE 448
             R +    L Q +     EQ  L  + +   ++++E+  + L   +++   ++  +H+ E
Sbjct: 1077 IRQQELSALRQDMQEAQGEQKELSAQMELLRQEVKEKEADFLAQEAQLLEELEA-SHITE 1135

Query: 449  K 449
            +
Sbjct: 1136 Q 1136



 Score = 43.1 bits (100), Expect = 7e-04
 Identities = 99/466 (21%), Positives = 178/466 (38%), Gaps = 76/466 (16%)

Query: 127 EELEQAAEGKEVRFQASLPLTRIDEEEAAAAPEAETERVEGEEEDKEETQRDGAESKERD 186
           EEL Q  E  E   Q +  L R++ E      + + +  +G++E+++E        +ER 
Sbjct: 473 EELRQQLEVLE---QEAWRLRRVNVEL-----QLQGDSAQGQKEEQQEELHLAVRERERL 524

Query: 187 GE---GRPAKSQEEGKRLYGRDEFEDLEWSEEVQKLQEQQLRSDLLDQYRSLLVERNRSQ 243
            E   G  AK  E    L    E            L+   L  +LL Q ++ +       
Sbjct: 525 QEMLMGLEAKQSESLSELITLRE-----------ALESSHLEGELLRQEQTEVTAA---- 569

Query: 244 RYNLYLQHKIFEALRRKKGLEAAEVADRGAEA-------EAPEKEQAYL-RHLGMLEELK 295
              L    +    L   +     EVAD  A A       EA   ++  L + L  LEE  
Sbjct: 570 ---LARAEQSIAELSSSENTLKTEVADLRAAAVKLSALNEALALDKVGLNQQLLQLEEEN 626

Query: 296 KQQADDLQWYHQELGQLKRQCQEKLTRVEKEWRRFQALKKQVVMQAMGSCRMRGGRQAAL 355
           +     ++   Q    L+    E   R E  W +   L+ Q+         ++   +   
Sbjct: 627 QSVCSRMEAAEQARNALQVDLAEAEKRREALWEKNTHLEAQLQKAEEAGAELQADLRDIQ 686

Query: 356 REVEQIQ--ALEDKKEKEMSAVRLEN---------------IQLKQSLVH----FETRM- 393
            E E+IQ    E + ++E +  +LE                +Q K++LV      E R+ 
Sbjct: 687 EEKEEIQKKLSESRHQQEAATTQLEQLHQEAKRQEEVLARAVQEKEALVREKAALEVRLQ 746

Query: 394 ---RTQEDLTQGLLLIDFEQLKIENQTFNEKIEERNEELLKLRSKVTNSVQVITHVKEKL 450
              R ++DL + L  +   +  +E+  F  + +++N  +   + ++   +Q +T  KE  
Sbjct: 747 AVERDRQDLAEQLQGLSSAKELLESSLF--EAQQQNSVIEVTKGQLEVQIQTVTQAKE-- 802

Query: 451 HFMDMENACKKTQLAEIEAQAALGRDILTKTKQAREGLRTDNIRLNQKCGLLGKDSLLRD 510
             +  E  C K +L    +QA   RD     +Q  +  +     L Q+     K+  +  
Sbjct: 803 -VIQGEVRCLKLELDTERSQAEQERD--AAARQLAQAEQEGKTALEQQKAAHEKE--VNQ 857

Query: 511 LEEKVDKTELLHRR-----LESLKRHHASLTLSCRGVRQKIREAKA 551
           L EK +K    H++     LESL+R    L +  +  + ++   +A
Sbjct: 858 LREKWEKERSWHQQELAKALESLEREKMELEMRLKEQQTEMEAIQA 903



 Score = 33.5 bits (75), Expect = 0.52
 Identities = 57/280 (20%), Positives = 110/280 (39%), Gaps = 23/280 (8%)

Query: 118  EELEAEAGAEELEQAAEGKEVRFQASLPLTRIDEEEAAAAPEAETERVEGEEEDKEETQR 177
            EEL  +   E+L + +  + V+         + +E+     E E E + G  +   E Q 
Sbjct: 2049 EELRHQQEREQLLEKSLAQRVQ-------ENMIQEKQNLGQEREEEEIRGLHQSVRELQL 2101

Query: 178  DGAESKERDGEGRPAKSQEEGKRLYGRDEFEDLEWSEEVQKLQEQQLRSDLLDQYRSLLV 237
              A+ ++   E R  +          R+  E L  S +   ++EQ L+ D L+      +
Sbjct: 2102 TLAQKEQEILELRETQQ---------RNNLEALPHSHKTSPMEEQSLKLDSLEPRLQREL 2152

Query: 238  ERNRSQRYNLYLQHKIFEALRRKKGLEAAEVADRGAEAEAPEKEQAYLRHLGMLEELKKQ 297
            ER ++       Q +  E   R+K  + A    +   + +  +E A      +LE   +Q
Sbjct: 2153 ERLQA----ALRQTEAREIEWREKAQDLALSLAQTKASVSSLQEVAMFLQASVLERDSEQ 2208

Query: 298  Q--ADDLQWYHQELGQLKRQCQEKLTRVEKEWRRFQALKKQVVMQAMGSCRMRGGRQAAL 355
            Q   D+L+   + L + +       +  E   R  Q ++   V          G  + + 
Sbjct: 2209 QRLQDELELTRRALEKERLHSPGATSTAELGSRGEQGVQLGEVSGVEAEPSPDGMEKQSW 2268

Query: 356  RE-VEQIQALEDKKEKEMSAVRLENIQLKQSLVHFETRMR 394
            R+ +E +Q    + E + S ++  N+QL+ +L   E   R
Sbjct: 2269 RQRLEHLQQAVARLEIDRSRLQRHNVQLRSTLEQVERERR 2308



 Score = 29.6 bits (65), Expect = 7.6
 Identities = 33/127 (25%), Positives = 52/127 (40%), Gaps = 21/127 (16%)

Query: 159  EAETERVEGEEE------DKEETQRDGAESK-ERDGEGRPAKSQEEGKRLYGR---DEFE 208
            ++E +R++ E E      +KE     GA S  E    G       E   +      D  E
Sbjct: 2205 DSEQQRLQDELELTRRALEKERLHSPGATSTAELGSRGEQGVQLGEVSGVEAEPSPDGME 2264

Query: 209  DLEWSEEVQKLQEQQLRSDLLDQYRSLLVERNRSQRYNLYLQHKI--FEALRRKKGLEAA 266
               W + ++ LQ+   R         L ++R+R QR+N+ L+  +   E  RRK   EA 
Sbjct: 2265 KQSWRQRLEHLQQAVAR---------LEIDRSRLQRHNVQLRSTLEQVERERRKLKREAM 2315

Query: 267  EVADRGA 273
              A  G+
Sbjct: 2316 RAAQAGS 2322


>gi|34878777 ring finger protein 20 [Homo sapiens]
          Length = 975

 Score = 59.3 bits (142), Expect = 9e-09
 Identities = 111/492 (22%), Positives = 202/492 (41%), Gaps = 120/492 (24%)

Query: 92  EPQPEPEEPAEVGAEEPAQPEPGAGPEELEAEAGAEELEQAAEGKEVRFQASLPLTRIDE 151
           + Q   E+P +    EPA+ +P +  E+L +++ A +  Q  +  E++       ++ DE
Sbjct: 521 QSQSSTEDPKD----EPAELKPDS--EDLSSQSSASKASQE-DANEIK-------SKRDE 566

Query: 152 EEAAAAPEAETERVEGEEEDKEETQRDGAESKER--------DGEGRPAKSQEEGKRLYG 203
           EE         ER   E+E + E +R+  + +ER        + E   AK +E+GK   G
Sbjct: 567 EER--------ERERREKEREREREREKEKEREREKQKLKESEKERDSAKDKEKGKHDDG 618

Query: 204 RDEFEDL--EWSEEVQKLQEQQLRSD-LLDQYRSLLVERNRSQRYNLYLQHKIFEALRRK 260
           R +  ++  +   E++K QE Q     LLD YRS      + QR  + L      A  +K
Sbjct: 619 RKKEAEIIKQLKIELKKAQESQKEMKLLLDMYRS----APKEQRDKVQLM-----AAEKK 669

Query: 261 KGLEAAEVADRGAEAEAPEKEQAYLRHLGMLEELKKQQADDLQWYHQELGQLKRQCQEKL 320
              E  ++  R  + E  EK++             K+ AD                    
Sbjct: 670 SKAELEDLRQRLKDLEDKEKKE------------NKKMAD-------------------- 697

Query: 321 TRVEKEWRRFQALKKQVVMQAMGSCRMRGGRQAALREVEQI-QALEDKKEKEMSAVRLEN 379
              E   R+ +A+++Q+          +   +A L E++   QA ED +E        +N
Sbjct: 698 ---EDALRKIRAVEEQIEYLQKKLAMAKQEEEALLSEMDVTGQAFEDMQE--------QN 746

Query: 380 IQLKQSLVHFETRMRTQEDLTQGLLLIDFEQLKIENQTFNEKIEERNEELLKLRSKVTNS 439
           I+L Q L       R ++D    L+    +  +I ++   E+ EE  +++L L+++V   
Sbjct: 747 IRLMQQL-------REKDDANFKLMSERIKSNQI-HKLLKEEKEELADQVLTLKTQVDAQ 798

Query: 440 VQVITHVKEKLHFMDM------ENACKKTQLAEIEAQ-----AALGRDILTKTKQAREGL 488
           +QV+  ++EK H +        +    +TQ  E+  +     A L  D+  + + A++ L
Sbjct: 799 LQVVRKLEEKEHLLQSNIGTGEKELGLRTQALEMNKRKAMEAAQLADDLKAQLELAQKKL 858

Query: 489 RTDNIRLNQKCGLLGKD-----------SLLRDLEEKVDKTELLHR----RLESLKRHHA 533
                 + +      KD           S LR   E   K + + +     +E +K + A
Sbjct: 859 HDFQDEIVENSVTKEKDMFNFKRAQEDISRLRRKLETTKKPDNVPKCDEILMEEIKDYKA 918

Query: 534 SLTLSCRGVRQK 545
            LT  C  +R+K
Sbjct: 919 RLTCPCCNMRKK 930



 Score = 37.4 bits (85), Expect = 0.036
 Identities = 77/352 (21%), Positives = 139/352 (39%), Gaps = 35/352 (9%)

Query: 4   SSEHTKDPGGEGG----DGESLAARPSKIKASSGPPTSPEPGELESEPEEE--EEEQAAS 57
           S   T+DP  E      D E L+++ S  KAS       +    E E E E  E+E+   
Sbjct: 522 SQSSTEDPKDEPAELKPDSEDLSSQSSASKASQEDANEIKSKRDEEERERERREKERERE 581

Query: 58  QGGTAADEQAEAPKGLTAAEAA------GEEGPGEPGRPAEPQPEPEEPAEVGAEEPAQP 111
           +      E+    + L  +E         E+G  + GR  E +   +   E+   + +Q 
Sbjct: 582 REREKEKEREREKQKLKESEKERDSAKDKEKGKHDDGRKKEAEIIKQLKIELKKAQESQK 641

Query: 112 EP-------GAGPEEL--EAEAGAEELEQAAEGKEVRFQASLPLTRIDEEEAAAAPEAET 162
           E         + P+E   + +  A E +  AE +++R +      +  +E    A E   
Sbjct: 642 EMKLLLDMYRSAPKEQRDKVQLMAAEKKSKAELEDLRQRLKDLEDKEKKENKKMADEDAL 701

Query: 163 ERVEGEEEDKEETQRDGAESKERDGEGRPAKSQEEGKRLYGRDEFEDLEWSEEVQKLQEQ 222
            ++   EE  E  Q+  A +K+ + E   ++    G+       FED++  E+  +L +Q
Sbjct: 702 RKIRAVEEQIEYLQKKLAMAKQEE-EALLSEMDVTGQ------AFEDMQ--EQNIRLMQQ 752

Query: 223 QLRSDLLDQYRSLLVERNRSQRYNLYLQHKIFEALRRKKGLEAAEVADRGAEAEAPEKEQ 282
               D  D    L+ ER +S + +  L+ +  E   +   L+    A      +  EKE 
Sbjct: 753 LREKD--DANFKLMSERIKSNQIHKLLKEEKEELADQVLTLKTQVDAQLQVVRKLEEKEH 810

Query: 283 AYLRHLGMLEE---LKKQQADDLQWYHQELGQLKRQCQEKLTRVEKEWRRFQ 331
               ++G  E+   L+ Q  +  +    E  QL    + +L   +K+   FQ
Sbjct: 811 LLQSNIGTGEKELGLRTQALEMNKRKAMEAAQLADDLKAQLELAQKKLHDFQ 862


>gi|157738649 neurofilament, medium polypeptide 150kDa isoform 1
           [Homo sapiens]
          Length = 916

 Score = 58.9 bits (141), Expect = 1e-08
 Identities = 74/295 (25%), Positives = 114/295 (38%), Gaps = 32/295 (10%)

Query: 6   EHTKDPGGEGGDGESLAARPSKIKASSGPPTSPEPGELESEPEEEEEEQAASQGGTAADE 65
           E TK    +    E+L A   ++  S          E E EPE EEEE AA +       
Sbjct: 458 EETKVEDEKSEMEEALTAITEELAVSMKEEKKEAAEEKEEEPEAEEEEVAAKK------- 510

Query: 66  QAEAPKGLTAAEAAGEEGPGEPGRPAEPQPEPEEPAEVGAEEPAQPEPGAGPEELEAEAG 125
              +P   TA E   EEG  E     E + E +E A+    E    E     E+ E E  
Sbjct: 511 ---SPVKATAPEVKEEEGEKEEEEGQEEEEEEDEGAKSDQAEEGGSEKEGSSEKEEGEQE 567

Query: 126 AEELEQAAEGKEVRFQASLPLTRIDEEEAAAAPEAETERVEGEEEDKEETQRDGAESKER 185
             E E  AEG                EEA A  E + E    E   KEE   D    K  
Sbjct: 568 EGETEAEAEG----------------EEAEAKEEKKVEEKSEEVATKEELVADAKVEKPE 611

Query: 186 DGEGRPAKS--QEEGKRLYGRDEFEDLEWSEEVQKLQEQQLRSDLLDQYRSLLVERNRSQ 243
             +    KS  +E+GK    +   E+   S   +   E++ +S +    +S + E+ +S 
Sbjct: 612 KAKSPVPKSPVEEKGKSPVPKSPVEEKGKSPVPKSPVEEKGKSPV---PKSPVEEKGKSP 668

Query: 244 RYNLYLQHKIFEALRRKKGLEAAEVADRGAEAEAPEKEQAYLRHLGMLEELKKQQ 298
                ++ K    + +    EA   A+ G + E  E+E+  ++     E+++K++
Sbjct: 669 VSKSPVEEKAKSPVPKSPVEEAKSKAEVG-KGEQKEEEEKEVKEAPKEEKVEKKE 722



 Score = 56.6 bits (135), Expect = 6e-08
 Identities = 58/250 (23%), Positives = 100/250 (40%), Gaps = 58/250 (23%)

Query: 2   DVSSEHTKDPGGEGGDGESLAARPSKIKASSGPPTSPEPGELESEPEEEEEEQA------ 55
           + + E  ++P  E    E +AA+ S +KA++ P    E GE E E  +EEEE+       
Sbjct: 490 EAAEEKEEEPEAEE---EEVAAKKSPVKATA-PEVKEEEGEKEEEEGQEEEEEEDEGAKS 545

Query: 56  --ASQGGTAAD-----EQAEAPKGLTAAEAAGEEGPGEPGRPAEPQ-------------- 94
             A +GG+  +     E+ E  +G T AEA GEE   +  +  E +              
Sbjct: 546 DQAEEGGSEKEGSSEKEEGEQEEGETEAEAEGEEAEAKEEKKVEEKSEEVATKEELVADA 605

Query: 95  ----------PEPEEPAEVGAEEPAQPEP---------GAGPEELEAEAGAEELEQAAEG 135
                     P P+ P E   + P    P            P E + ++   +     +G
Sbjct: 606 KVEKPEKAKSPVPKSPVEEKGKSPVPKSPVEEKGKSPVPKSPVEEKGKSPVPKSPVEEKG 665

Query: 136 K--------EVRFQASLPLTRIDEEEAAAAPEAETERVEGEEEDKEETQRDGAESKERDG 187
           K        E + ++ +P + ++E ++ A      ++ E E+E KE  + +  E KE   
Sbjct: 666 KSPVSKSPVEEKAKSPVPKSPVEEAKSKAEVGKGEQKEEEEKEVKEAPKEEKVEKKEEKP 725

Query: 188 EGRPAKSQEE 197
           +  P K + E
Sbjct: 726 KDVPEKKKAE 735



 Score = 41.2 bits (95), Expect = 0.003
 Identities = 55/203 (27%), Positives = 86/203 (42%), Gaps = 13/203 (6%)

Query: 29  KASSGPPTSP--EPGELESEPEEEEEEQAASQGGTAADEQAEAPKGLTAAEAAGEEGPGE 86
           KA S  P SP  E G+        EE+  +    +  +E+ ++P   +  E  G+    +
Sbjct: 612 KAKSPVPKSPVEEKGKSPVPKSPVEEKGKSPVPKSPVEEKGKSPVPKSPVEEKGKSPVSK 671

Query: 87  -PGRPAEPQPEPEEPAEVGAEEPAQPEPGAGPEELEAEAGAEELEQAAEGKEVRFQASLP 145
            P       P P+ P E  A+  A+   G   EE E E      E+  E KE +    +P
Sbjct: 672 SPVEEKAKSPVPKSPVEE-AKSKAEVGKGEQKEEEEKEVKEAPKEEKVEKKEEK-PKDVP 729

Query: 146 LTRIDE----EEAAAAPEAETE--RVEGEEEDKEETQRDGAESKERDGEGRPAKSQEEGK 199
             +  E    EEA A     T+  +V  E+E KEE  +   + KE++  G    S+EEG 
Sbjct: 730 EKKKAESPVKEEAVAEVVTITKSVKVHLEKETKEE-GKPLQQEKEKEKAGGEGGSEEEGS 788

Query: 200 RLYGR-DEFEDLEWSEEVQKLQE 221
               +    ED+  + EV+  +E
Sbjct: 789 DKGAKGSRKEDIAVNGEVEGKEE 811



 Score = 38.5 bits (88), Expect = 0.016
 Identities = 50/199 (25%), Positives = 81/199 (40%), Gaps = 40/199 (20%)

Query: 25  PSKIKASSGPPTSP--EPGE--LESEPEEEEEEQAASQGGTAADEQAEAPKG-LTAAEAA 79
           P + K  S  P SP  E G+  +   P EE+ +   S+       ++  PK  +  A++ 
Sbjct: 634 PVEEKGKSPVPKSPVEEKGKSPVPKSPVEEKGKSPVSKSPVEEKAKSPVPKSPVEEAKSK 693

Query: 80  GEEGPGEPGRPAEPQPEPEEPAEVGAEEPAQPEPGAGPEELEAEAGAEELEQAAE----- 134
            E G GE  +  E + E +E  +    E  + +P   PE+ +AE+  +E E  AE     
Sbjct: 694 AEVGKGE--QKEEEEKEVKEAPKEEKVEKKEEKPKDVPEKKKAESPVKE-EAVAEVVTIT 750

Query: 135 -------GKEVRFQASLPLTRIDEEEAAAAPEAETER-------------------VEGE 168
                   KE + +   PL +  E+E A       E                    VEG+
Sbjct: 751 KSVKVHLEKETKEEGK-PLQQEKEKEKAGGEGGSEEEGSDKGAKGSRKEDIAVNGEVEGK 809

Query: 169 EEDKEETQRDGAESKERDG 187
           EE ++ET+  G+  +E  G
Sbjct: 810 EEVEQETKEKGSGREEEKG 828



 Score = 37.7 bits (86), Expect = 0.028
 Identities = 41/168 (24%), Positives = 72/168 (42%), Gaps = 20/168 (11%)

Query: 127 EELEQAAEGKEVRFQASLPLTRIDEEEAAAAPEAETERVEGEEEDKEETQRDGAESKERD 186
           EE+ +  + ++ + +    LT I EE A +  E + E  E +EE+ E  + + A  K   
Sbjct: 454 EEIIEETKVEDEKSEMEEALTAITEELAVSMKEEKKEAAEEKEEEPEAEEEEVAAKKSPV 513

Query: 187 GEGRPAKSQEEGKRLYGRDEFEDLEWSEEVQKLQEQQLRSDLLDQYRSLLVERNRSQRYN 246
               P   +EEG+    ++E E  E  EE    +++  +SD  ++  S   E+  S    
Sbjct: 514 KATAPEVKEEEGE----KEEEEGQEEEEE----EDEGAKSDQAEEGGS---EKEGSSEK- 561

Query: 247 LYLQHKIFEALRRKKGLEAAEVADRGAEAEAPEKEQAYLRHLGMLEEL 294
                   E   +++G   AE     AEA+  +K +     +   EEL
Sbjct: 562 --------EEGEQEEGETEAEAEGEEAEAKEEKKVEEKSEEVATKEEL 601



 Score = 32.0 bits (71), Expect = 1.5
 Identities = 50/239 (20%), Positives = 95/239 (39%), Gaps = 47/239 (19%)

Query: 318 EKLTRVEKEWRRFQALKKQVVMQAMGSCRMRGGRQAALREVEQIQALEDKKEKEMSAVRL 377
           EK+  +E++ +  +A + Q + Q   S    G   A  +E+ +++A  +    E + V+L
Sbjct: 117 EKVHYLEQQNKEIEA-EIQALRQKQASHAQLG--DAYDQEIRELRATLEMVNHEKAQVQL 173

Query: 378 ENIQLKQSL----VHFETRMRTQEDLTQGLLLI--DFEQLKIENQTFNEKIEERNEELLK 431
           ++  L++ +      FE   R ++D    +  +  D E+  +     ++K++   +E+  
Sbjct: 174 DSDHLEEDIHRLKERFEEEARLRDDTEAAIRALRKDIEEASLVKVELDKKVQSLQDEVAF 233

Query: 432 LRSKVTNSVQVITHVKEKLHFMDMENACKKTQLAEIEAQAALGRDILTKTKQAREGLRTD 491
           LRS          H +E    +    A   T    +E +  L  DI T  K+ R      
Sbjct: 234 LRS---------NHEEEVADLLAQIQASHIT----VERKDYLKTDISTALKEIRS----- 275

Query: 492 NIRLNQKCGLLGKDSLLRDLEEKVDKTELLHRRLESLKRHHASLTLSCRGVRQKIREAK 550
                              LE   D+   +H+  E  K  +A LT +    ++ IR AK
Sbjct: 276 ------------------QLESHSDQN--MHQAEEWFKCRYAKLTEAAEQNKEAIRSAK 314


  Database: hs.faa
    Posted date:  Aug 4, 2009  4:42 PM
  Number of letters in database: 18,247,518
  Number of sequences in database:  37,866
  
Lambda     K      H
   0.307    0.127    0.342 

Gapped
Lambda     K      H
   0.267   0.0410    0.140 


Matrix: BLOSUM62
Gap Penalties: Existence: 11, Extension: 1
Number of Hits to DB: 23,326,455
Number of Sequences: 37866
Number of extensions: 1347441
Number of successful extensions: 28418
Number of sequences better than 10.0: 30
Number of HSP's better than 10.0 without gapping: 584
Number of HSP's successfully gapped in prelim test: 2184
Number of HSP's that attempted gapping in prelim test: 12266
Number of HSP's gapped (non-prelim): 10895
length of query: 555
length of database: 18,247,518
effective HSP length: 107
effective length of query: 448
effective length of database: 14,195,856
effective search space: 6359743488
effective search space used: 6359743488
T: 11
A: 40
X1: 16 ( 7.1 bits)
X2: 38 (14.6 bits)
X3: 64 (24.7 bits)
S1: 42 (21.6 bits)
S2: 64 (29.3 bits)

Search results were obtained with NCBI BLAST and RefSeq entries.

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Guide to the Human Genome
Copyright © 2010 by Stewart Scherer. All rights reserved.