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Search of human proteins with 23111034
BLASTP 2.2.11 [Jun-05-2005]
Reference: Altschul, Stephen F., Thomas L. Madden, Alejandro A. Schaffer,
Jinghui Zhang, Zheng Zhang, Webb Miller, and David J. Lipman (1997),
"Gapped BLAST and PSI-BLAST: a new generation of protein database search
programs", Nucleic Acids Res. 25:3389-3402.
Query= gi|23111034 sorting nexin 1 isoform a [Homo sapiens]
(522 letters)
Database: hs.faa
37,866 sequences; 18,247,518 total letters
Searching..................................................done
Score E
Sequences producing significant alignments: (bits) Value
gi|23111034 sorting nexin 1 isoform a [Homo sapiens] 1026 0.0
gi|23111036 sorting nexin 1 isoform c [Homo sapiens] 900 0.0
gi|23111032 sorting nexin 1 isoform b [Homo sapiens] 791 0.0
gi|23111038 sorting nexin 2 [Homo sapiens] 593 e-170
gi|194294540 sorting nexin 7 isoform a [Homo sapiens] 101 2e-21
gi|23111047 sorting nexin 5 [Homo sapiens] 98 2e-20
gi|7657599 sorting nexin 5 [Homo sapiens] 98 2e-20
gi|23111055 sorting nexin 7 isoform b [Homo sapiens] 95 1e-19
gi|72534838 sorting nexin 6B [Homo sapiens] 92 2e-18
gi|153791707 sorting nexin family member 30 [Homo sapiens] 85 1e-16
gi|88703041 sorting nexin 6 isoform b [Homo sapiens] 84 3e-16
gi|23111030 sorting nexin 12 [Homo sapiens] 76 9e-14
gi|4507143 sorting nexin 3 isoform a [Homo sapiens] 72 9e-13
gi|23111026 sorting nexin 11 [Homo sapiens] 65 2e-10
gi|23111028 sorting nexin 11 [Homo sapiens] 65 2e-10
gi|88703043 sorting nexin 6 isoform a [Homo sapiens] 54 3e-07
gi|23397574 sorting nexin 33 [Homo sapiens] 54 3e-07
gi|68800430 HCLS1 binding protein 3 [Homo sapiens] 53 6e-07
gi|157502171 sorting nexin 19 [Homo sapiens] 53 6e-07
gi|23238244 sorting nexin 16 isoform a [Homo sapiens] 52 1e-06
gi|23238246 sorting nexin 16 isoform a [Homo sapiens] 52 1e-06
gi|23111023 sorting nexin 10 [Homo sapiens] 50 5e-06
gi|224177511 sorting nexin 18 isoform c [Homo sapiens] 50 7e-06
gi|157057545 sorting nexin 18 isoform a [Homo sapiens] 50 7e-06
gi|157057543 sorting nexin 18 isoform b [Homo sapiens] 50 7e-06
gi|23943858 sorting nexin 8 [Homo sapiens] 48 2e-05
gi|31563383 serum/glucocorticoid regulated kinase 3 isoform 2 [H... 48 2e-05
gi|31563382 serum/glucocorticoid regulated kinase 3 isoform 1 [H... 48 2e-05
gi|75813626 serum/glucocorticoid regulated kinase 3 isoform 1 [H... 48 2e-05
gi|4507145 sorting nexin 4 [Homo sapiens] 46 9e-05
>gi|23111034 sorting nexin 1 isoform a [Homo sapiens]
Length = 522
Score = 1026 bits (2652), Expect = 0.0
Identities = 522/522 (100%), Positives = 522/522 (100%)
Query: 1 MASGGGGCSASERLPPPFPGLEPESEGAAGGSEPEAGDSDTEGEDIFTGAAVVSKHQSPK 60
MASGGGGCSASERLPPPFPGLEPESEGAAGGSEPEAGDSDTEGEDIFTGAAVVSKHQSPK
Sbjct: 1 MASGGGGCSASERLPPPFPGLEPESEGAAGGSEPEAGDSDTEGEDIFTGAAVVSKHQSPK 60
Query: 61 ITTSLLPINNGSKENGIHEEQDQEPQDLFADATVELSLDSTQNNQKKVLAKTLISLPPQE 120
ITTSLLPINNGSKENGIHEEQDQEPQDLFADATVELSLDSTQNNQKKVLAKTLISLPPQE
Sbjct: 61 ITTSLLPINNGSKENGIHEEQDQEPQDLFADATVELSLDSTQNNQKKVLAKTLISLPPQE 120
Query: 121 ATNSSKPQPTYEELEEEEQEDQFDLTVGITDPEKIGDGMNAYVAYKVTTQTSLPLFRSKQ 180
ATNSSKPQPTYEELEEEEQEDQFDLTVGITDPEKIGDGMNAYVAYKVTTQTSLPLFRSKQ
Sbjct: 121 ATNSSKPQPTYEELEEEEQEDQFDLTVGITDPEKIGDGMNAYVAYKVTTQTSLPLFRSKQ 180
Query: 181 FAVKRRFSDFLGLYEKLSEKHSQNGFIVPPPPEKSLIGMTKVKVGKEDSSSAEFLEKRRA 240
FAVKRRFSDFLGLYEKLSEKHSQNGFIVPPPPEKSLIGMTKVKVGKEDSSSAEFLEKRRA
Sbjct: 181 FAVKRRFSDFLGLYEKLSEKHSQNGFIVPPPPEKSLIGMTKVKVGKEDSSSAEFLEKRRA 240
Query: 241 ALERYLQRIVNHPTMLQDPDVREFLEKEELPRAVGTQTLSGAGLLKMFNKATDAVSKMTI 300
ALERYLQRIVNHPTMLQDPDVREFLEKEELPRAVGTQTLSGAGLLKMFNKATDAVSKMTI
Sbjct: 241 ALERYLQRIVNHPTMLQDPDVREFLEKEELPRAVGTQTLSGAGLLKMFNKATDAVSKMTI 300
Query: 301 KMNESDIWFEEKLQEVECEEQRLRKLHAVVETLVNHRKELALNTAQFAKSLAMLGSSEDN 360
KMNESDIWFEEKLQEVECEEQRLRKLHAVVETLVNHRKELALNTAQFAKSLAMLGSSEDN
Sbjct: 301 KMNESDIWFEEKLQEVECEEQRLRKLHAVVETLVNHRKELALNTAQFAKSLAMLGSSEDN 360
Query: 361 TALSRALSQLAEVEEKIEQLHQEQANNDFFLLAELLSDYIRLLAIVRAAFDQRMKTWQRW 420
TALSRALSQLAEVEEKIEQLHQEQANNDFFLLAELLSDYIRLLAIVRAAFDQRMKTWQRW
Sbjct: 361 TALSRALSQLAEVEEKIEQLHQEQANNDFFLLAELLSDYIRLLAIVRAAFDQRMKTWQRW 420
Query: 421 QDAQATLQKKREAEARLLWANKPDKLQQAKDEILEWESRVTQYERDFERISTVVRKEVIR 480
QDAQATLQKKREAEARLLWANKPDKLQQAKDEILEWESRVTQYERDFERISTVVRKEVIR
Sbjct: 421 QDAQATLQKKREAEARLLWANKPDKLQQAKDEILEWESRVTQYERDFERISTVVRKEVIR 480
Query: 481 FEKEKSKDFKNHVIKYLETLLYSQQQLAKYWEAFLPEAKAIS 522
FEKEKSKDFKNHVIKYLETLLYSQQQLAKYWEAFLPEAKAIS
Sbjct: 481 FEKEKSKDFKNHVIKYLETLLYSQQQLAKYWEAFLPEAKAIS 522
>gi|23111036 sorting nexin 1 isoform c [Homo sapiens]
Length = 474
Score = 900 bits (2327), Expect = 0.0
Identities = 473/522 (90%), Positives = 474/522 (90%), Gaps = 48/522 (9%)
Query: 1 MASGGGGCSASERLPPPFPGLEPESEGAAGGSEPEAGDSDTEGEDIFTGAAVVSKHQSPK 60
MASGGGGCSASERLPPPFPGLEPESEGAAGGSEPEAGDSDTEGEDIFTGAAVVSKHQSPK
Sbjct: 1 MASGGGGCSASERLPPPFPGLEPESEGAAGGSEPEAGDSDTEGEDIFTGAAVVSKHQSPK 60
Query: 61 ITTSLLPINNGSKENGIHEEQDQEPQDLFADATVELSLDSTQNNQKKVLAKTLISLPPQE 120
ITTSLLPINNGSKENGIHEEQDQEPQDLFADATVELSLDSTQNNQKKVLAKTLISLPPQE
Sbjct: 61 ITTSLLPINNGSKENGIHEEQDQEPQDLFADATVELSLDSTQNNQKKVLAKTLISLPPQE 120
Query: 121 ATNSSKPQPTYEELEEEEQEDQFDLTVGITDPEKIGDGMNAYVAYKVTTQTSLPLFRSKQ 180
ATNSSKPQPTYEELEEEEQEDQFDLTVGITDPEKIGDGMNAYVAYKVTTQTSLPLFRSKQ
Sbjct: 121 ATNSSKPQPTYEELEEEEQEDQFDLTVGITDPEKIGDGMNAYVAYKVTTQTSLPLFRSKQ 180
Query: 181 FAVKRRFSDFLGLYEKLSEKHSQNGFIVPPPPEKSLIGMTKVKVGKEDSSSAEFLEKRRA 240
FAVKRRFSDFLGLYEKLSEKHSQNGFIVPPPPEKSLIGMTKVKVGKEDSSSAEFLEKRRA
Sbjct: 181 FAVKRRFSDFLGLYEKLSEKHSQNGFIVPPPPEKSLIGMTKVKVGKEDSSSAEFLEKRRA 240
Query: 241 ALERYLQRIVNHPTMLQDPDVREFLEKEELPRAVGTQTLSGAGLLKMFNKATDAVSKMTI 300
ALERYLQRIVNHPTMLQDPDVREFLEKEELPRAVGTQTLSGAGLLKMFNKATDAVSKMTI
Sbjct: 241 ALERYLQRIVNHPTMLQDPDVREFLEKEELPRAVGTQTLSGAGLLKMFNKATDAVSKMTI 300
Query: 301 KMNESDIWFEEKLQEVECEEQRLRKLHAVVETLVNHRKELALNTAQFAKSLAMLGSSEDN 360
KMNESDIWFEEKLQEVECEEQRLRKLHAVVETLVNHRKELALNTAQFAKSLAMLGSSEDN
Sbjct: 301 KMNESDIWFEEKLQEVECEEQRLRKLHAVVETLVNHRKELALNTAQFAKSLAMLGSSEDN 360
Query: 361 TALSRALSQLAEVEEKIEQLHQEQANNDFFLLAELLSDYIRLLAIVRAAFDQRMKTWQRW 420
TALSRALSQLAEVEEKIEQLHQEQANNDFFLLAELLSDYIRLLAIVR W+
Sbjct: 361 TALSRALSQLAEVEEKIEQLHQEQANNDFFLLAELLSDYIRLLAIVR---------WE-- 409
Query: 421 QDAQATLQKKREAEARLLWANKPDKLQQAKDEILEWESRVTQYERDFERISTVVRKEVIR 480
SRVTQYERDFERISTVVRKEVIR
Sbjct: 410 -------------------------------------SRVTQYERDFERISTVVRKEVIR 432
Query: 481 FEKEKSKDFKNHVIKYLETLLYSQQQLAKYWEAFLPEAKAIS 522
FEKEKSKDFKNHVIKYLETLLYSQQQLAKYWEAFLPEAKAIS
Sbjct: 433 FEKEKSKDFKNHVIKYLETLLYSQQQLAKYWEAFLPEAKAIS 474
>gi|23111032 sorting nexin 1 isoform b [Homo sapiens]
Length = 457
Score = 791 bits (2043), Expect = 0.0
Identities = 424/522 (81%), Positives = 436/522 (83%), Gaps = 65/522 (12%)
Query: 1 MASGGGGCSASERLPPPFPGLEPESEGAAGGSEPEAGDSDTEGEDIFTGAAVVSKHQSPK 60
MASGGGGCSASERLPPPFPGLEPESEGAAGGSEPEAGDSDTEG
Sbjct: 1 MASGGGGCSASERLPPPFPGLEPESEGAAGGSEPEAGDSDTEG----------------- 43
Query: 61 ITTSLLPINNGSKENGIHEEQDQEPQDLFADATVELSLDSTQNNQKKVLAKTLISLPPQE 120
+D+F A V +Q + +L+ +
Sbjct: 44 -------------------------EDIFTGAAV------VSKHQSPKITTSLLPI---- 68
Query: 121 ATNSSKPQPTYEELEEEEQEDQFDLTVGITDPEKIGDGMNAYVAYKVTTQTSLPLFRSKQ 180
N SK +EE +++E +D F GDGMNAYVAYKVTTQTSLPLFRSKQ
Sbjct: 69 -NNGSKENGIHEE-QDQEPQDLF-----------AGDGMNAYVAYKVTTQTSLPLFRSKQ 115
Query: 181 FAVKRRFSDFLGLYEKLSEKHSQNGFIVPPPPEKSLIGMTKVKVGKEDSSSAEFLEKRRA 240
FAVKRRFSDFLGLYEKLSEKHSQNGFIVPPPPEKSLIGMTKVKVGKEDSSSAEFLEKRRA
Sbjct: 116 FAVKRRFSDFLGLYEKLSEKHSQNGFIVPPPPEKSLIGMTKVKVGKEDSSSAEFLEKRRA 175
Query: 241 ALERYLQRIVNHPTMLQDPDVREFLEKEELPRAVGTQTLSGAGLLKMFNKATDAVSKMTI 300
ALERYLQRIVNHPTMLQDPDVREFLEKEELPRAVGTQTLSGAGLLKMFNKATDAVSKMTI
Sbjct: 176 ALERYLQRIVNHPTMLQDPDVREFLEKEELPRAVGTQTLSGAGLLKMFNKATDAVSKMTI 235
Query: 301 KMNESDIWFEEKLQEVECEEQRLRKLHAVVETLVNHRKELALNTAQFAKSLAMLGSSEDN 360
KMNESDIWFEEKLQEVECEEQRLRKLHAVVETLVNHRKELALNTAQFAKSLAMLGSSEDN
Sbjct: 236 KMNESDIWFEEKLQEVECEEQRLRKLHAVVETLVNHRKELALNTAQFAKSLAMLGSSEDN 295
Query: 361 TALSRALSQLAEVEEKIEQLHQEQANNDFFLLAELLSDYIRLLAIVRAAFDQRMKTWQRW 420
TALSRALSQLAEVEEKIEQLHQEQANNDFFLLAELLSDYIRLLAIVRAAFDQRMKTWQRW
Sbjct: 296 TALSRALSQLAEVEEKIEQLHQEQANNDFFLLAELLSDYIRLLAIVRAAFDQRMKTWQRW 355
Query: 421 QDAQATLQKKREAEARLLWANKPDKLQQAKDEILEWESRVTQYERDFERISTVVRKEVIR 480
QDAQATLQKKREAEARLLWANKPDKLQQAKDEILEWESRVTQYERDFERISTVVRKEVIR
Sbjct: 356 QDAQATLQKKREAEARLLWANKPDKLQQAKDEILEWESRVTQYERDFERISTVVRKEVIR 415
Query: 481 FEKEKSKDFKNHVIKYLETLLYSQQQLAKYWEAFLPEAKAIS 522
FEKEKSKDFKNHVIKYLETLLYSQQQLAKYWEAFLPEAKAIS
Sbjct: 416 FEKEKSKDFKNHVIKYLETLLYSQQQLAKYWEAFLPEAKAIS 457
>gi|23111038 sorting nexin 2 [Homo sapiens]
Length = 519
Score = 593 bits (1530), Expect = e-170
Identities = 318/532 (59%), Positives = 390/532 (73%), Gaps = 33/532 (6%)
Query: 10 ASERLPPPFPGLEPESEGAAGGSEPEAGDSDTEGEDIFTGAAVVSKHQSPKITTSLLPI- 68
A+ER PPP G +P + +GED+FT + + LP
Sbjct: 2 AAEREPPPL-----------GDGKPTDFEDLEDGEDLFTSTVSTLESSPSSPEPASLPAE 50
Query: 69 -----NNGSKENGIHEEQDQEPQDLFADATVELSLDSTQNNQ----------KKVLAKTL 113
+NG K + + D+E DLFA+AT E+SLDS + V TL
Sbjct: 51 DISANSNGPKPTEVVLDDDRE--DLFAEATEEVSLDSPEREPILSSEPSPAVTPVTPTTL 108
Query: 114 ISLPPQEATNSSKP---QPTYEELEEEEQEDQFDLTVGITDPEKIGDGMNAYVAYKVTTQ 170
I+ P E+ + S P + EE+EEE D FD+ +G++DPEK+GDGMNAY+AY+VTT+
Sbjct: 109 IA-PRIESKSMSAPVIFDRSREEIEEEANGDIFDIEIGVSDPEKVGDGMNAYMAYRVTTK 167
Query: 171 TSLPLFRSKQFAVKRRFSDFLGLYEKLSEKHSQNGFIVPPPPEKSLIGMTKVKVGKEDSS 230
TSL +F +F+VKRRFSDFLGL+ KL+ K+ G+IVPP PEKS++GMTKVKVGKEDSS
Sbjct: 168 TSLSMFSKSEFSVKRRFSDFLGLHSKLASKYLHVGYIVPPAPEKSIVGMTKVKVGKEDSS 227
Query: 231 SAEFLEKRRAALERYLQRIVNHPTMLQDPDVREFLEKEELPRAVGTQTLSGAGLLKMFNK 290
S EF+EKRRAALERYLQR V HPT+LQDPD+R+FLE ELPRAV TQ LSGAG+L+M NK
Sbjct: 228 STEFVEKRRAALERYLQRTVKHPTLLQDPDLRQFLESSELPRAVNTQALSGAGILRMVNK 287
Query: 291 ATDAVSKMTIKMNESDIWFEEKLQEVECEEQRLRKLHAVVETLVNHRKELALNTAQFAKS 350
A DAV+KMTIKMNESD WFEEK Q+ E +Q+LRKLH VE LV HRKEL+ NTA FAKS
Sbjct: 288 AADAVNKMTIKMNESDAWFEEKQQQFENLDQQLRKLHVSVEALVCHRKELSANTAAFAKS 347
Query: 351 LAMLGSSEDNTALSRALSQLAEVEEKIEQLHQEQANNDFFLLAELLSDYIRLLAIVRAAF 410
AMLG+SED+TALSRALSQLAEVEEKI+QLHQEQA DF++ +ELLSDYIRL+A V+ F
Sbjct: 348 AAMLGNSEDHTALSRALSQLAEVEEKIDQLHQEQAFADFYMFSELLSDYIRLIAAVKGVF 407
Query: 411 DQRMKTWQRWQDAQATLQKKREAEARLLWANKPDKLQQAKDEILEWESRVTQYERDFERI 470
D RMK WQ+W+DAQ TL KKREAEA+++ ANKPDK+QQAK+EI EWE++V Q ERDFE+I
Sbjct: 408 DHRMKCWQKWEDAQITLLKKREAEAKMMVANKPDKIQQAKNEIREWEAKVQQGERDFEQI 467
Query: 471 STVVRKEVIRFEKEKSKDFKNHVIKYLETLLYSQQQLAKYWEAFLPEAKAIS 522
S +RKEV RFEKE+ KDFK +IKYLE+L+ +QQQL KYWEAFLPEAKAI+
Sbjct: 468 SKTIRKEVGRFEKERVKDFKTVIIKYLESLVQTQQQLIKYWEAFLPEAKAIA 519
>gi|194294540 sorting nexin 7 isoform a [Homo sapiens]
Length = 451
Score = 101 bits (251), Expect = 2e-21
Identities = 83/391 (21%), Positives = 174/391 (44%), Gaps = 31/391 (7%)
Query: 125 SKPQPTYEELEEEEQEDQFDLTVGITDPEKIGDGMNAYVAYKVTTQTSLPLFRSKQFAVK 184
+ P +++ E++ D DL + + +PE + ++ Y++ T+TS F S +F V+
Sbjct: 76 TSPLSMINQIKFEDEPDLKDLFITVDEPESHVTTIETFITYRIITKTSRGEFDSSEFEVR 135
Query: 185 RRFSDFLGLYEKLSEKHSQNGFIVPPPPEKSLIGMTKVKVGKEDSSSAEFLEKRRAALER 244
RR+ DFL L KL E H I+PP PEK ++ G + + +F+E RR AL +
Sbjct: 136 RRYQDFLWLKGKLEEAHPT--LIIPPLPEKFIV------KGMVERFNDDFIETRRKALHK 187
Query: 245 YLQRIVNHPTMLQDPDVREFLEKEELPRAVGTQTLSGAGLLKMFNKATDAVSKMTIKMNE 304
+L RI +HPT+ + D + FL + + + G GLL + AV+ +
Sbjct: 188 FLNRIADHPTLTFNEDFKIFLTAQAW--ELSSHKKQGPGLLSRMGQTVRAVASSMRGVKN 245
Query: 305 SDIWFEEKLQEVECEEQRLRKLHAVVETLVNHRKELALNTAQFAKSLAMLGSSEDNTALS 364
F E +E Q++ + + + + +E ++ + +SE++ L
Sbjct: 246 RPEEFMEMNNFIELFSQKINLIDKISQRIYKEEREYFDEMKEYGPIHILWSASEED--LV 303
Query: 365 RALSQLAEVEEKIEQLHQEQANNDFFLLAELLSDYIRLLAIVRAAFDQRMKTWQRWQDAQ 424
L +A ++ + +++ + L ++ +Y+ ++ +R + Q D++
Sbjct: 304 DTLKDVASCIDRCCKATEKRMSGLSEALLPVVHEYVLYSEMLMGVMKRRDQI-QAELDSK 362
Query: 425 ATLQKKREAEARLLWANKPDKLQQAKDEILEWESRVTQYERDFERISTVVRKEVIRFEKE 484
+ ++A+ LL P+++ + +D++ E + ++ + R+++
Sbjct: 363 VEVLTYKKADTDLL----PEEIGKLEDKV--------------ECANNALKADWERWKQN 404
Query: 485 KSKDFKNHVIKYLETLLYSQQQLAKYWEAFL 515
D K E ++ +Q WE+FL
Sbjct: 405 MQNDIKLAFTDMAEENIHYYEQCLATWESFL 435
>gi|23111047 sorting nexin 5 [Homo sapiens]
Length = 404
Score = 97.8 bits (242), Expect = 2e-20
Identities = 100/399 (25%), Positives = 188/399 (47%), Gaps = 56/399 (14%)
Query: 133 ELEEEEQEDQ-------FDLTVGITDPEKIGDGMNAY--VAYKVTTQTSLPLFRSKQFAV 183
EL ++++ED+ DL V + I D ++ V + V T+T+LP F+S +F+V
Sbjct: 6 ELLQQQEEDRSKLRSVSVDLNVDPSLQIDIPDALSERDKVKFTVHTKTTLPTFQSPEFSV 65
Query: 184 KRRFSDFLGLYEKLSEKHSQNGFIVPPPPEKSLI---------------GMTKVKVGK-E 227
R+ DF+ L++ L E G I+PP P K MTK + K +
Sbjct: 66 TRQHEDFVWLHDTLIETTDYAGLIIPPAPTKPDFDGPREKMQKLGEGEGSMTKEEFAKMK 125
Query: 228 DSSSAEFL---EKRRAALERYLQRIVNHPTMLQDPDVREFLEKEE--LPRAVGTQTLSGA 282
AE+L +K ++ E +LQR+ +HP + +D + FLE ++ R T+ + G
Sbjct: 126 QELEAEYLAVFKKTVSSHEVFLQRLSSHPVLSKDRNFHVFLEYDQDLSVRRKNTKEMFG- 184
Query: 283 GLLKMFNKATDAVSKMTIKMNESDIWFEEKLQEVECEEQRLRKLHAVVETLVNHRKELA- 341
G K K+ D V +K E D +FE++ + R++ + + K +A
Sbjct: 185 GFFKSVVKSADEVLFTGVK--EVDDFFEQEKNFLINYYNRIKDSCVKADKMTRSHKNVAD 242
Query: 342 --LNTAQFAKSLAMLGSSEDNTALSRALSQLAEVEEKIEQLHQEQANNDFFLLAELLSDY 399
++TA SLA+ E+ T + + L ++AE+ EK+ ++ ++++ L ELL Y
Sbjct: 243 DYIHTAACLHSLAL----EEPTVIKKYLLKVAELFEKLRKVEGRVSSDEDLKLTELLRYY 298
Query: 400 IRLLAIVRAAFDQRMKTWQRWQDAQATLQKKREAEARLLWANKPDKLQQAKDEILEWESR 459
+ + + +R K ++++ L K R +K KL +A +
Sbjct: 299 MLNIEAAKDLLYRRTKALIDYENSNKALDKAR-------LKSKDVKLAEAHQQ------- 344
Query: 460 VTQYERDFERISTVVRKEVIRFEKEKSKDFKNHVIKYLE 498
+ + FE++S ++E+I F++++ F+ ++I+ E
Sbjct: 345 --ECCQKFEQLSESAKEELINFKRKRVAAFRKNLIEMSE 381
>gi|7657599 sorting nexin 5 [Homo sapiens]
Length = 404
Score = 97.8 bits (242), Expect = 2e-20
Identities = 100/399 (25%), Positives = 188/399 (47%), Gaps = 56/399 (14%)
Query: 133 ELEEEEQEDQ-------FDLTVGITDPEKIGDGMNAY--VAYKVTTQTSLPLFRSKQFAV 183
EL ++++ED+ DL V + I D ++ V + V T+T+LP F+S +F+V
Sbjct: 6 ELLQQQEEDRSKLRSVSVDLNVDPSLQIDIPDALSERDKVKFTVHTKTTLPTFQSPEFSV 65
Query: 184 KRRFSDFLGLYEKLSEKHSQNGFIVPPPPEKSLI---------------GMTKVKVGK-E 227
R+ DF+ L++ L E G I+PP P K MTK + K +
Sbjct: 66 TRQHEDFVWLHDTLIETTDYAGLIIPPAPTKPDFDGPREKMQKLGEGEGSMTKEEFAKMK 125
Query: 228 DSSSAEFL---EKRRAALERYLQRIVNHPTMLQDPDVREFLEKEE--LPRAVGTQTLSGA 282
AE+L +K ++ E +LQR+ +HP + +D + FLE ++ R T+ + G
Sbjct: 126 QELEAEYLAVFKKTVSSHEVFLQRLSSHPVLSKDRNFHVFLEYDQDLSVRRKNTKEMFG- 184
Query: 283 GLLKMFNKATDAVSKMTIKMNESDIWFEEKLQEVECEEQRLRKLHAVVETLVNHRKELA- 341
G K K+ D V +K E D +FE++ + R++ + + K +A
Sbjct: 185 GFFKSVVKSADEVLFTGVK--EVDDFFEQEKNFLINYYNRIKDSCVKADKMTRSHKNVAD 242
Query: 342 --LNTAQFAKSLAMLGSSEDNTALSRALSQLAEVEEKIEQLHQEQANNDFFLLAELLSDY 399
++TA SLA+ E+ T + + L ++AE+ EK+ ++ ++++ L ELL Y
Sbjct: 243 DYIHTAACLHSLAL----EEPTVIKKYLLKVAELFEKLRKVEGRVSSDEDLKLTELLRYY 298
Query: 400 IRLLAIVRAAFDQRMKTWQRWQDAQATLQKKREAEARLLWANKPDKLQQAKDEILEWESR 459
+ + + +R K ++++ L K R +K KL +A +
Sbjct: 299 MLNIEAAKDLLYRRTKALIDYENSNKALDKAR-------LKSKDVKLAEAHQQ------- 344
Query: 460 VTQYERDFERISTVVRKEVIRFEKEKSKDFKNHVIKYLE 498
+ + FE++S ++E+I F++++ F+ ++I+ E
Sbjct: 345 --ECCQKFEQLSESAKEELINFKRKRVAAFRKNLIEMSE 381
>gi|23111055 sorting nexin 7 isoform b [Homo sapiens]
Length = 336
Score = 95.1 bits (235), Expect = 1e-19
Identities = 73/334 (21%), Positives = 149/334 (44%), Gaps = 36/334 (10%)
Query: 125 SKPQPTYEELEEEEQEDQFDLTVGITDPEKIGDGMNAYVAYKVTTQTSLPLFRSKQFAVK 184
+ P +++ E++ D DL + + +PE + ++ Y++ T+TS F S +F V+
Sbjct: 12 TSPLSMINQIKFEDEPDLKDLFITVDEPESHVTTIETFITYRIITKTSRGEFDSSEFEVR 71
Query: 185 RRFSDFLGLYEKLSEKHSQNGFIVPPPPEKSLIGMTKVKVGKEDSSSAEFLEKRRAALER 244
RR+ DFL L KL E H I+PP PEK ++ G + + +F+E RR AL +
Sbjct: 72 RRYQDFLWLKGKLEEAHPT--LIIPPLPEKFIV------KGMVERFNDDFIETRRKALHK 123
Query: 245 YLQRIVNHPTMLQDPDVREFLEKEELPRAVGTQTLSGAGLLKMFNKATDAVSKMTIKMNE 304
+L RI +HPT+ + D + FL + + + G GLL + AV+ +
Sbjct: 124 FLNRIADHPTLTFNEDFKIFLTAQAW--ELSSHKKQGPGLLSRMGQTVRAVASSMRGVKN 181
Query: 305 SDIWFEEKLQEVECEEQRLRKLHAVVETLVNHRKELALNTAQFAKSLAMLGSSEDNTALS 364
F E +E Q++ + + + + +E ++ + +SE++ L
Sbjct: 182 RPEEFMEMNNFIELFSQKINLIDKISQRIYKEEREYFDEMKEYGPIHILWSASEED--LV 239
Query: 365 RALSQLAEVEEKIEQLHQEQAN----------NDFFLLAELLSDYIRLLAIVRAAFDQRM 414
L +A ++ + +++ + +++ L +E+L ++ ++A D ++
Sbjct: 240 DTLKDVASCIDRCCKATEKRMSGLSEALLPVVHEYVLYSEMLMGVMKRRDQIQAELDSKV 299
Query: 415 K--------------TWQRWQDAQATLQKKREAE 434
+ TW+ + +Q L + +E
Sbjct: 300 EVLTYKKADTDLCLATWESFLTSQTNLHLEEASE 333
>gi|72534838 sorting nexin 6B [Homo sapiens]
Length = 403
Score = 91.7 bits (226), Expect = 2e-18
Identities = 86/357 (24%), Positives = 162/357 (45%), Gaps = 38/357 (10%)
Query: 163 VAYKVTTQTSLPLFRSKQFAVKRRFSDFLGLYEKLSEKHSQNGFIVPPPPEKSLIGMTK- 221
V + V T++ LP F +F+V R+ +F+ L++ E G I+PP P + ++
Sbjct: 40 VKFTVQTKSCLPHFAQTEFSVVRQHEEFIWLHDAYVENEEYAGLIIPPAPPRPDFEASRE 99
Query: 222 --VKVGKEDSS-------------SAEFL---EKRRAALERYLQRIVNHPTMLQDPDVRE 263
K+G+ DSS AE+L +K A E +LQR+ HPT+ +D +
Sbjct: 100 KLQKLGEGDSSVTREEFAKMKQELEAEYLAIFKKTVAMHEVFLQRLAAHPTLRRDHNFFV 159
Query: 264 FLE--KEELPRAVGTQTLSGAGLLKMFNKATDAVSKMTIKMNESDIWFEEKLQEVECEEQ 321
FLE ++ R + L G L + A +A+ + E D +FE + +
Sbjct: 160 FLEYGQDLSVRGKNRKELLGGFLRNIVKSADEALITGMSGLKEVDDFFEHERTFLLEYHT 219
Query: 322 RLRKLHAVVETLVNHRKELALNTAQFAKSLAMLGSSEDNTALSRALSQLAEVEEKIEQLH 381
R+R + ++ K LA + + +L+ LG+ E N L + +LAE+ E++ +L
Sbjct: 220 RIRDACLRADRVMRAHKCLADDYIPISAALSSLGTQEVN-QLRTSFLKLAELFERLRKLE 278
Query: 382 QEQANNDFFLLAELLSDYIRLLAIVRAAFDQRMKTWQRWQDAQATLQKKREAEARLLWAN 441
A+++ L+++L Y+R + +R++ +++A L
Sbjct: 279 GRVASDEDLKLSDMLRYYMRDSQAAKDLLYRRLRALADYENANKAL-------------- 324
Query: 442 KPDKLQQAKDEILEWESRVTQYERDFERISTVVRKEVIRFEKEKSKDFKNHVIKYLE 498
DK + E+ ES + FER+S ++E++ F+ + F+ ++I+ E
Sbjct: 325 --DKARTRNREVRPAESHQQLCCQRFERLSDSAKQELMDFKSRRVSSFRKNLIELAE 379
>gi|153791707 sorting nexin family member 30 [Homo sapiens]
Length = 437
Score = 85.1 bits (209), Expect = 1e-16
Identities = 83/386 (21%), Positives = 169/386 (43%), Gaps = 38/386 (9%)
Query: 133 ELEEEEQEDQFDLTVGITDPEKIGDGMNAYVAYKVTTQTSLPLFRSKQFAVKRRFSDFLG 192
+L+++ + DL V + DP+K M Y+ Y++TT+++ F +++V+RR+ DF
Sbjct: 79 QLDDDIDGETRDLFVIVDDPKKHVCTMETYITYRITTKSTRVEFDLPEYSVRRRYQDFDW 138
Query: 193 LYEKLSEKHSQNGFIVPPPPEKSLIGMTKVKVGKEDSSSAEFLEKRRAALERYLQRIVNH 252
L KL E SQ ++PP PEK ++ G D S EF+E RR AL+++L+RI +H
Sbjct: 139 LRSKLEE--SQPTHLIPPLPEKFVV------KGVVDRFSEEFVETRRKALDKFLKRITDH 190
Query: 253 PTMLQDPDVREFLEKEELPRAVGTQTLSGAGLLKMFNKATDAVSKMTIKMNESDIWFEEK 312
P + + FL ++L G LL ++ V+ K+ + F
Sbjct: 191 PVLSFNEHFNIFLTAKDL----NAYKKQGIALLTRMGESVKHVTG-GYKLRTRPLEFAAI 245
Query: 313 LQEVECEEQRLRKLHAVVETLVNHRKELALNTAQFAKSLAMLGSSEDNTA--LSRALSQL 370
++ +L + + + ++ E + ++ + + E A L + +
Sbjct: 246 GDYLDTFALKLGTIDRIAQRIIKEEIEYLVELREYGPVYSTWSALEGELAEPLEGVSACI 305
Query: 371 AEVEEKIEQLHQEQANNDFFLLAELLSDYIRLLAIVRAAFDQRMKTWQRWQDAQATLQKK 430
+E+L + DF +L +YI + MK+ + +D +Q +
Sbjct: 306 GNCSTALEEL-TDDMTEDFL---PVLREYI--------LYSDSMKSVLKKRD---QVQAE 350
Query: 431 REAEARLLWANKPDKLQQAKDEILEWESRVTQYERDFERISTVVRKEVIRFEKEKSKDFK 490
EA+ + K D+ + D V + + E + ++ ++ R++ K +DF+
Sbjct: 351 YEAKLEAVALRKEDRPKVPAD--------VEKCQDRMECFNADLKADMERWQNNKRQDFR 402
Query: 491 NHVIKYLETLLYSQQQLAKYWEAFLP 516
++ + + ++ WE+ +P
Sbjct: 403 QLLMGMADKNIQYYEKCLMAWESIIP 428
>gi|88703041 sorting nexin 6 isoform b [Homo sapiens]
Length = 418
Score = 84.0 bits (206), Expect = 3e-16
Identities = 81/377 (21%), Positives = 164/377 (43%), Gaps = 47/377 (12%)
Query: 142 QFDLTVGITDPEKIGDGMNAYVAYKVTTQTSLPLFRSKQFAVKRRFSDFLGLYEKLSEKH 201
Q D++ +++ +K V + V T++SLP F+ +F+V R+ +F+ L++ E
Sbjct: 45 QVDISDALSERDK--------VKFTVHTKSSLPNFKQNEFSVVRQHEEFIWLHDSFVENE 96
Query: 202 SQNGFIVPPPPEKSLIGMTKVKVGK----EDSSSAEFLEKRRAALER------------- 244
G+I+PP P + ++ K+ K E S + E K + LE
Sbjct: 97 DYAGYIIPPAPPRPDFDASREKLQKLGEGEGSMTKEEFTKMKQELEAEYLAIFKKTVAMH 156
Query: 245 --YLQRIVNHPTMLQDPDVREFLE-KEELPRAVGTQTLSGAGLLKMFNKATDAVSKMTIK 301
+L R+ HP + +D + FLE ++L + K K+ D V +K
Sbjct: 157 EVFLCRVAAHPILRRDLNFHVFLEYNQDLSVRGKNKKEKLEDFFKNMVKSADGVIVSGVK 216
Query: 302 MNESDIWFEEKLQEVECEEQRLRKLHAVVETLVNHRKELALNTAQFAKSLAMLGSSEDNT 361
+ D +FE + + R++ A + + K A + + SL LG ++D+T
Sbjct: 217 --DVDDFFEHERTFLLEYHNRVKDASAKSDRMTRSHKSAADDYNRIGSSLYALG-TQDST 273
Query: 362 ALSRALSQLAEVEEKIEQLHQEQANNDFFLLAELLSDYIRLLAIVRAAFDQRMKTWQRWQ 421
+ + +++E+ +K ++ + ++ L++LL Y+R + +R ++ ++
Sbjct: 274 DICKFFLKVSELFDKTRKIEARVSADEDLKLSDLLKYYLRESQAAKDLLYRRSRSLVDYE 333
Query: 422 DAQATLQKKREAEARLLWANKPDKLQQAKDEILEWESRVTQYERDFERISTVVRKEVIRF 481
+A L K R +L A +L K FE+IS ++E+I F
Sbjct: 334 NANKALDKARAKNKDVLQAETSQQLCCQK----------------FEKISESAKQELIDF 377
Query: 482 EKEKSKDFKNHVIKYLE 498
+ + F+ ++++ E
Sbjct: 378 KTRRVAAFRKNLVELAE 394
>gi|23111030 sorting nexin 12 [Homo sapiens]
Length = 162
Score = 75.9 bits (185), Expect = 9e-14
Identities = 48/149 (32%), Positives = 81/149 (54%), Gaps = 8/149 (5%)
Query: 124 SSKPQPTYEELEEEEQEDQFDLTVGITDPEKIGDGMNAYVAYKVTTQTSLPLFRSKQFAV 183
+SKPQ +L + L + I +P+ +G G + Y+V +T+LP+F+ K+ V
Sbjct: 13 NSKPQ----DLTDAYGPPSNFLEIDIFNPQTVGVGRARFTTYEVRMRTNLPIFKLKESCV 68
Query: 184 KRRFSDFLGLYEKLSEKHSQNGFIVPPPPEKSLIGMTKVKVGKEDSSSAEFLEKRRAALE 243
+RR+SDF L +L E+ S+ +VPP P K+L + G E F+E+RR LE
Sbjct: 69 RRRYSDFEWLKNEL-ERDSK--IVVPPLPGKALKRQLPFR-GDEGIFEESFIEERRQGLE 124
Query: 244 RYLQRIVNHPTMLQDPDVREFLEKEELPR 272
+++ +I HP + + FL++E + R
Sbjct: 125 QFINKIAGHPLAQNERCLHMFLQEEAIDR 153
>gi|4507143 sorting nexin 3 isoform a [Homo sapiens]
Length = 162
Score = 72.4 bits (176), Expect = 9e-13
Identities = 35/129 (27%), Positives = 72/129 (55%), Gaps = 4/129 (3%)
Query: 145 LTVGITDPEKIGDGMNAYVAYKVTTQTSLPLFRSKQFAVKRRFSDFLGLYEKLSEKHSQN 204
L + +++P+ +G G + Y++ +T+LP+F+ K+ V+RR+SDF L SE ++
Sbjct: 29 LEIDVSNPQTVGVGRGRFTTYEIRVKTNLPIFKLKESTVRRRYSDFEWL---RSELERES 85
Query: 205 GFIVPPPPEKSLIGMTKVKVGKEDSSSAEFLEKRRAALERYLQRIVNHPTMLQDPDVREF 264
+VPP P K+ + + G + F+E+R+ LE+++ ++ HP + + F
Sbjct: 86 KVVVPPLPGKAFLRQLPFR-GDDGIFDDNFIEERKQGLEQFINKVAGHPLAQNERCLHMF 144
Query: 265 LEKEELPRA 273
L+ E + ++
Sbjct: 145 LQDEIIDKS 153
>gi|23111026 sorting nexin 11 [Homo sapiens]
Length = 270
Score = 64.7 bits (156), Expect = 2e-10
Identities = 43/135 (31%), Positives = 70/135 (51%), Gaps = 17/135 (12%)
Query: 137 EEQEDQFDLTVGITDPEKIGDGM-NAYVAYKVTTQTSLPLFRSKQFAVKRRFSDFLGLYE 195
E QE + +TV + DP +G N+YV YK+ T+ F +K V+RR+ +F+ L +
Sbjct: 9 ENQEQEEVITVRVQDPRVQNEGSWNSYVDYKIFLHTNSKAFTAKTSCVRRRYREFVWLRK 68
Query: 196 KLSEKHSQNGFIVPPP--PEKSLIGMTKVKVGKEDSSSAEFLEKRRAALERYLQRIVNHP 253
+L +N +VP P P KS T S EF+EKRR L+ +L++++
Sbjct: 69 QLQ----RNAGLVPVPELPGKSTFFGT----------SDEFIEKRRQGLQHFLEKVLQSV 114
Query: 254 TMLQDPDVREFLEKE 268
+L D + FL+ +
Sbjct: 115 VLLSDSQLHLFLQSQ 129
>gi|23111028 sorting nexin 11 [Homo sapiens]
Length = 270
Score = 64.7 bits (156), Expect = 2e-10
Identities = 43/135 (31%), Positives = 70/135 (51%), Gaps = 17/135 (12%)
Query: 137 EEQEDQFDLTVGITDPEKIGDGM-NAYVAYKVTTQTSLPLFRSKQFAVKRRFSDFLGLYE 195
E QE + +TV + DP +G N+YV YK+ T+ F +K V+RR+ +F+ L +
Sbjct: 9 ENQEQEEVITVRVQDPRVQNEGSWNSYVDYKIFLHTNSKAFTAKTSCVRRRYREFVWLRK 68
Query: 196 KLSEKHSQNGFIVPPP--PEKSLIGMTKVKVGKEDSSSAEFLEKRRAALERYLQRIVNHP 253
+L +N +VP P P KS T S EF+EKRR L+ +L++++
Sbjct: 69 QLQ----RNAGLVPVPELPGKSTFFGT----------SDEFIEKRRQGLQHFLEKVLQSV 114
Query: 254 TMLQDPDVREFLEKE 268
+L D + FL+ +
Sbjct: 115 VLLSDSQLHLFLQSQ 129
>gi|88703043 sorting nexin 6 isoform a [Homo sapiens]
Length = 290
Score = 54.3 bits (129), Expect = 3e-07
Identities = 62/285 (21%), Positives = 124/285 (43%), Gaps = 24/285 (8%)
Query: 219 MTKVKVGK-EDSSSAEFL---EKRRAALERYLQRIVNHPTMLQDPDVREFLE-KEELPRA 273
MTK + K + AE+L +K A E +L R+ HP + +D + FLE ++L
Sbjct: 1 MTKEEFTKMKQELEAEYLAIFKKTVAMHEVFLCRVAAHPILRRDLNFHVFLEYNQDLSVR 60
Query: 274 VGTQTLSGAGLLKMFNKATDAVSKMTIKMNESDIWFEEKLQEVECEEQRLRKLHAVVETL 333
+ K K+ D V +K + D +FE + + R++ A + +
Sbjct: 61 GKNKKEKLEDFFKNMVKSADGVIVSGVK--DVDDFFEHERTFLLEYHNRVKDASAKSDRM 118
Query: 334 VNHRKELALNTAQFAKSLAMLGSSEDNTALSRALSQLAEVEEKIEQLHQEQANNDFFLLA 393
K A + + SL LG ++D+T + + +++E+ +K ++ + ++ L+
Sbjct: 119 TRSHKSAADDYNRIGSSLYALG-TQDSTDICKFFLKVSELFDKTRKIEARVSADEDLKLS 177
Query: 394 ELLSDYIRLLAIVRAAFDQRMKTWQRWQDAQATLQKKREAEARLLWANKPDKLQQAKDEI 453
+LL Y+R + +R ++ +++A L K R +L A +L K
Sbjct: 178 DLLKYYLRESQAAKDLLYRRSRSLVDYENANKALDKARAKNKDVLQAETSQQLCCQK--- 234
Query: 454 LEWESRVTQYERDFERISTVVRKEVIRFEKEKSKDFKNHVIKYLE 498
FE+IS ++E+I F+ + F+ ++++ E
Sbjct: 235 -------------FEKISESAKQELIDFKTRRVAAFRKNLVELAE 266
>gi|23397574 sorting nexin 33 [Homo sapiens]
Length = 574
Score = 53.9 bits (128), Expect = 3e-07
Identities = 106/516 (20%), Positives = 190/516 (36%), Gaps = 95/516 (18%)
Query: 26 EGAAGGSEPEAGDSDTEGE---DIFTGAAVVSKHQSPKITTSLLPINN-GSKENGIHEEQ 81
+G EP AG T G ++ A S+H + + L ++ S + G +
Sbjct: 122 DGCTVVEEPRAGGLGTNGHPPLNLSYPGAYPSQHMAFRPKPPLERQDSLASAKRGSVVGR 181
Query: 82 DQEPQDLFADATVELSLDSTQNNQKKVLAKTLISLPPQEATNSSKPQPTYEELEEEEQED 141
+ F + VE + K+ I + P+ + P P +E+ ++
Sbjct: 182 NLNRFSCFVRSGVEAFILGDVPMMAKIAETYSIEMGPRGPQWKANPHPFACSVEDPTKQT 241
Query: 142 QFDLTVGITDPEKIGDGMNAYVAYKVT-TQTSLPLFRSKQFAVKRRFSDFLGLYEKLSEK 200
+F G+ +Y++YK+T T + P++R R+ F LY +L K
Sbjct: 242 KFK-------------GIKSYISYKLTPTHAASPVYR--------RYKHFDWLYNRLLHK 280
Query: 201 HSQNGFIVPPPPEKSLIGMTKVKVGKEDSSSAEFLEKRRAALERYLQRIVNHPTMLQDPD 260
+ VP PEK G + +F+EKR+ L ++ + +HP + Q
Sbjct: 281 FTV--ISVPHLPEKQATGRFE----------EDFIEKRKRRLILWMDHMTSHPVLSQYEG 328
Query: 261 VREFL------EKEELPRAVGTQTLSGAGLLKMFNKATDAVSKMTIKMNESDIW--FEEK 312
+ FL + + R + GA L F T+ ++ + D + F +K
Sbjct: 329 FQHFLSCLDDKQWKMGKRRAEKDEMVGASFLLTFQIPTEHQDLQDVE-DRVDTFKAFSKK 387
Query: 313 LQEVECEEQRLRKLHAVVETLVNHRKELALNTAQFAKSLAMLGSSED------------- 359
+ + + +L V LV + F K LGS+
Sbjct: 388 M------DDSVLQLSTVASELVRK------HVGGFRKEFQKLGSAFQAISHSFQMDPPFC 435
Query: 360 NTALSRALSQLAEVEEKIEQLHQEQANNDFFLLAELLSDYIRLLAIVRAAFDQRMKTWQR 419
+ AL+ A+S E I ++ EQ ND F + + LS Y LL+
Sbjct: 436 SEALNSAISHTGRTYEAIGEMFAEQPKNDLFQMLDTLSLYQGLLS--------------N 481
Query: 420 WQDAQATLQKKREAEARLLWANKPDKLQQAKDEILEWESRVTQYERDFERISTVVRKEVI 479
+ D LQK A+ + + Q+ DE + R + ++ E+
Sbjct: 482 FPDI-IHLQKGAFAKVK--------ESQRMSDEGRMVQDEADGIRRRCRVVGFALQAEMN 532
Query: 480 RFEKEKSKDFKNHVIKYLETLLYSQQQLAKYWEAFL 515
F + + DFK+ + YL + Q++ + E L
Sbjct: 533 HFHQRRELDFKHMMQNYLRQQILFYQRVGQQLEKTL 568
>gi|68800430 HCLS1 binding protein 3 [Homo sapiens]
Length = 392
Score = 53.1 bits (126), Expect = 6e-07
Identities = 50/182 (27%), Positives = 78/182 (42%), Gaps = 32/182 (17%)
Query: 144 DLTVGITDPEKIGDGMNAYVAYKVTTQTSLPLFRSK--------QFAVKRRFSDFLGLYE 195
DLTV E G M+ +V Y++ T L F+S QF V +++S+ Y+
Sbjct: 21 DLTVP-QHQEVRGKMMSGHVEYQILVVTRLAAFKSAKHRPEDVVQFLVSKKYSEIEEFYQ 79
Query: 196 KLSEKHSQNGFIVPPPPEKSLIGMTKVKVGKEDSSSAEFLEKRRAALERYLQRIVNHPTM 255
KLS +++ +PP P K L VG+ D + +RRA L+ + +
Sbjct: 80 KLSSRYAAAS--LPPLPRKVLF------VGESD------IRERRAVFNEILRCVSKDAEL 125
Query: 256 LQDPDVREFLEKEELPRAVGTQTLSGAGLLKMFNKATDAVSKMTIKMNESDIWFEEKLQE 315
P++ EFL GT++ AGL + D T E+ +FEE+ Q
Sbjct: 126 AGSPELLEFL---------GTRSPGAAGLTSRDSSVLDGTDSQTGNDEEAFDFFEEQDQV 176
Query: 316 VE 317
E
Sbjct: 177 AE 178
>gi|157502171 sorting nexin 19 [Homo sapiens]
Length = 992
Score = 53.1 bits (126), Expect = 6e-07
Identities = 72/268 (26%), Positives = 109/268 (40%), Gaps = 45/268 (16%)
Query: 21 LEPESEGAAGGSEPEAGDSDTEGEDIFTGAAVVSKHQSPKITTSLLPINNGSKENGIHEE 80
LEP+ A+ G+E E G G + TG V + + P+I I+ KE
Sbjct: 411 LEPKDGEASEGAEAEEGP----GTETETGLPVSTLNSCPEIH-----IDTADKEI----- 456
Query: 81 QDQEPQDLFADATV-----ELSLDSTQNNQKKVLAKTLISLPPQ---EATNSSKPQP--- 129
E D+ A T E + S + +K L + SL P +SS P P
Sbjct: 457 ---EQGDVTASVTALLEGPEKTCPSRPSCLEKDLTNDVSSLDPTLPPVLLSSSPPGPLSS 513
Query: 130 ---TYEELEEEEQE---DQFDLTVGITDPEKIGDGMNAYVAYKVTTQTSLP------LFR 177
++E L + +T IT E G G + Y Y V +T+L L +
Sbjct: 514 ATFSFEPLSSPDGPVIIQNLRITGTITAREHSGTGFHPYTLYTVKYETALDGENSSGLQQ 573
Query: 178 SKQFAVKRRFSDFLGLYEKLSEKHSQNGFIVPPPPEKSLIGMTKVKVGKEDSSSAEFLEK 237
V RR+ +FL L +L EK FI K L + G DS + +E
Sbjct: 574 LAYHTVNRRYREFLNLQTRLEEKPDLRKFIKNVKGPKKL--FPDLPFGNMDS---DRVEA 628
Query: 238 RRAALERYLQRIVNHPTMLQDPDVREFL 265
R++ LE +L+++ P + +V+EFL
Sbjct: 629 RKSLLESFLKQLCAIPEIANSEEVQEFL 656
>gi|23238244 sorting nexin 16 isoform a [Homo sapiens]
Length = 344
Score = 52.0 bits (123), Expect = 1e-06
Identities = 57/254 (22%), Positives = 111/254 (43%), Gaps = 28/254 (11%)
Query: 89 FADATVELSLDSTQNNQKKVLAKTLISLPPQEATNSSKPQPTYEELEEEEQEDQFDLTVG 148
F +V +D+T + L +T + S++P+ T E+ E + T
Sbjct: 52 FKQTSVPDQMDNTSSVCSSPLIRTKFTGTASSIEYSTRPRDTEEQNPETVNWEDRPSTPT 111
Query: 149 ITDPEKIGDGMNAYVAYKVTTQTSLPLFRSKQFAVKRRFSDFLGLYEKLSEKHSQNGFIV 208
I E + + + YK+ + + + + V RR++DF L +KL E GF +
Sbjct: 112 ILGYEVMEERAK-FTVYKILVKKT----PEESWVVFRRYTDFSRLNDKLKEMFP--GFRL 164
Query: 209 PPPPEKSLIGMTKVKVGKEDSSSAEFLEKRRAALERYLQRIVNHPTMLQDPDVREFLEKE 268
PP++ +D+ +A+FLE R+ L+ +LQ +V H + VREFL +
Sbjct: 165 ALPPKRWF----------KDNYNADFLEDRQLGLQAFLQNLVAHKDIANCLAVREFLCLD 214
Query: 269 ELPRAVGTQTLSGAGLLKMFNKATDAVSKMTIKMNESDIWFEEKLQEVECEEQRLRKLHA 328
+ P + L+ + + + ++ + + EK +E+E ++ L +
Sbjct: 215 DPPGPFDS--------LEESRAFCETLEETNYRLQKELL---EKQKEMESLKKLLSEKQL 263
Query: 329 VVETLVNHRKELAL 342
++TL N + L+L
Sbjct: 264 HIDTLENRIRTLSL 277
>gi|23238246 sorting nexin 16 isoform a [Homo sapiens]
Length = 344
Score = 52.0 bits (123), Expect = 1e-06
Identities = 57/254 (22%), Positives = 111/254 (43%), Gaps = 28/254 (11%)
Query: 89 FADATVELSLDSTQNNQKKVLAKTLISLPPQEATNSSKPQPTYEELEEEEQEDQFDLTVG 148
F +V +D+T + L +T + S++P+ T E+ E + T
Sbjct: 52 FKQTSVPDQMDNTSSVCSSPLIRTKFTGTASSIEYSTRPRDTEEQNPETVNWEDRPSTPT 111
Query: 149 ITDPEKIGDGMNAYVAYKVTTQTSLPLFRSKQFAVKRRFSDFLGLYEKLSEKHSQNGFIV 208
I E + + + YK+ + + + + V RR++DF L +KL E GF +
Sbjct: 112 ILGYEVMEERAK-FTVYKILVKKT----PEESWVVFRRYTDFSRLNDKLKEMFP--GFRL 164
Query: 209 PPPPEKSLIGMTKVKVGKEDSSSAEFLEKRRAALERYLQRIVNHPTMLQDPDVREFLEKE 268
PP++ +D+ +A+FLE R+ L+ +LQ +V H + VREFL +
Sbjct: 165 ALPPKRWF----------KDNYNADFLEDRQLGLQAFLQNLVAHKDIANCLAVREFLCLD 214
Query: 269 ELPRAVGTQTLSGAGLLKMFNKATDAVSKMTIKMNESDIWFEEKLQEVECEEQRLRKLHA 328
+ P + L+ + + + ++ + + EK +E+E ++ L +
Sbjct: 215 DPPGPFDS--------LEESRAFCETLEETNYRLQKELL---EKQKEMESLKKLLSEKQL 263
Query: 329 VVETLVNHRKELAL 342
++TL N + L+L
Sbjct: 264 HIDTLENRIRTLSL 277
>gi|23111023 sorting nexin 10 [Homo sapiens]
Length = 201
Score = 50.1 bits (118), Expect = 5e-06
Identities = 37/149 (24%), Positives = 77/149 (51%), Gaps = 21/149 (14%)
Query: 137 EEQEDQFDLTVGITDPE-KIGDGMNAYVAYKVTTQTSLPLFRSKQFAVKRRFSDFLGLYE 195
E+Q+++F ++V + DP + D ++Y+ Y++ T+ F K V+RR+ +F+ L +
Sbjct: 4 EQQKEEF-VSVWVRDPRIQKEDFWHSYIDYEICIHTNSMCFTMKTSCVRRRYREFVWLRQ 62
Query: 196 KLSEKHSQNGFIV--PPPPEKSLIGMTKVKVGKEDSSSAEFLEKRRAALERYLQRIVNHP 253
+L N +V P P K+L + ++ + +++RR LE +L++++ +
Sbjct: 63 RL----QSNALLVQLPELPSKNLF---------FNMNNRQHVDQRRQGLEDFLRKVLQNA 109
Query: 254 TMLQDPDVREFLE----KEELPRAVGTQT 278
+L D + FL+ E++ V QT
Sbjct: 110 LLLSDSSLHLFLQSHLNSEDIEACVSGQT 138
>gi|224177511 sorting nexin 18 isoform c [Homo sapiens]
Length = 591
Score = 49.7 bits (117), Expect = 7e-06
Identities = 72/291 (24%), Positives = 113/291 (38%), Gaps = 61/291 (20%)
Query: 137 EEQEDQFDLTVGITDPEKIGD--GMNAYVAYK-VTTQTSLPLFRSKQFAVKRRFSDFLGL 193
E QE+ + I DP K GM +Y++YK V T T +P V RR+ F L
Sbjct: 268 EWQENPYPFQCTIDDPTKQTKFKGMKSYISYKLVPTHTQVP--------VHRRYKHFDWL 319
Query: 194 YEKLSEKHSQNGFIVPPPPEKSLIGMTKVKVGKEDSSSAEFLEKRRAALERYLQRIVNHP 253
Y +L+EK VP PEK G + +F+ KRR L ++ + +HP
Sbjct: 320 YARLAEKFPV--ISVPHLPEKQATGRFE----------EDFISKRRKGLIWWMNHMASHP 367
Query: 254 TMLQDPDVREFL------------------EKEELPRAVGTQTLS---GAGL-LKMFNKA 291
+ Q + FL EK+E+ A TLS A L L+
Sbjct: 368 VLAQCDVFQHFLTCPSSTDEKAWKQGKRKAEKDEMVGANFFLTLSTPPAAALDLQEVESK 427
Query: 292 TDAVSKMTIKMNESDIWFEEKLQEVECEEQRLRKLHAVVETLVNHRKELALNTAQFAKSL 351
D T KM++S + E ++ + +KE Q + L
Sbjct: 428 IDGFKCFTKKMDDSALQLNHTANEFARKQ------------VTGFKKEYQ-KVGQSFRGL 474
Query: 352 AM---LGSSEDNTALSRALSQLAEVEEKIEQLHQEQANNDFFLLAELLSDY 399
+ L + L++A++ + + I +L EQ D + +LL+ Y
Sbjct: 475 SQAFELDQQAFSVGLNQAIAFTGDAYDAIGELFAEQPRQDLDPVMDLLALY 525
>gi|157057545 sorting nexin 18 isoform a [Homo sapiens]
Length = 624
Score = 49.7 bits (117), Expect = 7e-06
Identities = 72/291 (24%), Positives = 113/291 (38%), Gaps = 61/291 (20%)
Query: 137 EEQEDQFDLTVGITDPEKIGD--GMNAYVAYK-VTTQTSLPLFRSKQFAVKRRFSDFLGL 193
E QE+ + I DP K GM +Y++YK V T T +P V RR+ F L
Sbjct: 268 EWQENPYPFQCTIDDPTKQTKFKGMKSYISYKLVPTHTQVP--------VHRRYKHFDWL 319
Query: 194 YEKLSEKHSQNGFIVPPPPEKSLIGMTKVKVGKEDSSSAEFLEKRRAALERYLQRIVNHP 253
Y +L+EK VP PEK G + +F+ KRR L ++ + +HP
Sbjct: 320 YARLAEKFPV--ISVPHLPEKQATGRFE----------EDFISKRRKGLIWWMNHMASHP 367
Query: 254 TMLQDPDVREFL------------------EKEELPRAVGTQTLS---GAGL-LKMFNKA 291
+ Q + FL EK+E+ A TLS A L L+
Sbjct: 368 VLAQCDVFQHFLTCPSSTDEKAWKQGKRKAEKDEMVGANFFLTLSTPPAAALDLQEVESK 427
Query: 292 TDAVSKMTIKMNESDIWFEEKLQEVECEEQRLRKLHAVVETLVNHRKELALNTAQFAKSL 351
D T KM++S + E ++ + +KE Q + L
Sbjct: 428 IDGFKCFTKKMDDSALQLNHTANEFARKQ------------VTGFKKEYQ-KVGQSFRGL 474
Query: 352 AM---LGSSEDNTALSRALSQLAEVEEKIEQLHQEQANNDFFLLAELLSDY 399
+ L + L++A++ + + I +L EQ D + +LL+ Y
Sbjct: 475 SQAFELDQQAFSVGLNQAIAFTGDAYDAIGELFAEQPRQDLDPVMDLLALY 525
>gi|157057543 sorting nexin 18 isoform b [Homo sapiens]
Length = 628
Score = 49.7 bits (117), Expect = 7e-06
Identities = 72/291 (24%), Positives = 113/291 (38%), Gaps = 61/291 (20%)
Query: 137 EEQEDQFDLTVGITDPEKIGD--GMNAYVAYK-VTTQTSLPLFRSKQFAVKRRFSDFLGL 193
E QE+ + I DP K GM +Y++YK V T T +P V RR+ F L
Sbjct: 268 EWQENPYPFQCTIDDPTKQTKFKGMKSYISYKLVPTHTQVP--------VHRRYKHFDWL 319
Query: 194 YEKLSEKHSQNGFIVPPPPEKSLIGMTKVKVGKEDSSSAEFLEKRRAALERYLQRIVNHP 253
Y +L+EK VP PEK G + +F+ KRR L ++ + +HP
Sbjct: 320 YARLAEKFPV--ISVPHLPEKQATGRFE----------EDFISKRRKGLIWWMNHMASHP 367
Query: 254 TMLQDPDVREFL------------------EKEELPRAVGTQTLS---GAGL-LKMFNKA 291
+ Q + FL EK+E+ A TLS A L L+
Sbjct: 368 VLAQCDVFQHFLTCPSSTDEKAWKQGKRKAEKDEMVGANFFLTLSTPPAAALDLQEVESK 427
Query: 292 TDAVSKMTIKMNESDIWFEEKLQEVECEEQRLRKLHAVVETLVNHRKELALNTAQFAKSL 351
D T KM++S + E ++ + +KE Q + L
Sbjct: 428 IDGFKCFTKKMDDSALQLNHTANEFARKQ------------VTGFKKEYQ-KVGQSFRGL 474
Query: 352 AM---LGSSEDNTALSRALSQLAEVEEKIEQLHQEQANNDFFLLAELLSDY 399
+ L + L++A++ + + I +L EQ D + +LL+ Y
Sbjct: 475 SQAFELDQQAFSVGLNQAIAFTGDAYDAIGELFAEQPRQDLDPVMDLLALY 525
>gi|23943858 sorting nexin 8 [Homo sapiens]
Length = 465
Score = 47.8 bits (112), Expect = 2e-05
Identities = 77/342 (22%), Positives = 142/342 (41%), Gaps = 66/342 (19%)
Query: 152 PEKIGDGMNAYVAYKVTTQTSLPLFRSKQFAVKRRFSDFLGLYEKLSEKHSQNGFIVPPP 211
PEK G + +V Y+V++Q F+S +V RR++DF+ E L K +VP
Sbjct: 83 PEKKGLFLK-HVEYEVSSQR----FKS---SVYRRYNDFVVFQEMLLHKFPYR--MVPAL 132
Query: 212 PEKSLIGMTKVKVGKEDSSSAEFLEKRRAALERYLQRIVNHPTMLQDPDVREFL------ 265
P K ++G + EF+E RR AL+R++ + HP +D ++ FL
Sbjct: 133 PPKRMLGADR-----------EFIEARRRALKRFVNLVARHPLFSEDVVLKLFLSFSGSD 181
Query: 266 ---EKEELPRAVGTQTLSGAGLLKMFNKATDAVSKMTIKMNESDIWFEEKLQEVECEEQR 322
+ +E + VG + L+ K+ +A D + + F + +
Sbjct: 182 VQNKLKESAQCVGDEFLN----CKLATRAKDFLPA------DIQAQFAISRELIRNIYNS 231
Query: 323 LRKLHAVVETLVNHRKELALNTAQFAKSLAMLGS------------SEDNTALSRALS-- 368
KL E + + + A + F K L+ +GS S +L +AL
Sbjct: 232 FHKLRDRAERIASRAIDNAADLLIFGKELSAIGSDTTPLPSWAALNSSTWGSLKQALKGL 291
Query: 369 --QLAEVEEKIEQLHQEQANNDFFLLAELLSDYIRLLAIVRAAFDQRMKTWQRWQDAQAT 426
+ A + +K Q +++ N+ + E L+ ++ LL + ++ K Q
Sbjct: 292 SVEFALLADKAAQQGKQEEND----VVEKLNLFLDLLQSYKDLCERHEK--GVLHKHQRA 345
Query: 427 LQK----KREAEARLLWANKPDKLQQAKDEILEWESRVTQYE 464
L K KR+ + +P+ ++Q + I+E E+ + E
Sbjct: 346 LHKYSLMKRQMMSATAQNREPESVEQLESRIVEQENAIQTME 387
>gi|31563383 serum/glucocorticoid regulated kinase 3 isoform 2 [Homo
sapiens]
Length = 464
Score = 47.8 bits (112), Expect = 2e-05
Identities = 33/123 (26%), Positives = 58/123 (47%), Gaps = 17/123 (13%)
Query: 146 TVGITDPEKIGDGMNAYVAYKVTTQTSLPLFRSKQFAVKRRFSDFLGLYEKLSEKHSQNG 205
+V I ++ + + YKV RS+ F V RR+++F LY L ++
Sbjct: 15 SVSIPSSDEHREKKKRFTVYKVLVSVG----RSEWF-VFRRYAEFDKLYNTLKKQFPAMA 69
Query: 206 FIVPPPPEKSLIGMTKVKVGKEDSSSAEFLEKRRAALERYLQRIVNHPTMLQDPDVREFL 265
+P K + G D+ +F+++RRA L ++Q +V +P + PDVR FL
Sbjct: 70 LKIPA---KRIFG---------DNFDPDFIKQRRAGLNEFIQNLVRYPELYNHPDVRAFL 117
Query: 266 EKE 268
+ +
Sbjct: 118 QMD 120
>gi|31563382 serum/glucocorticoid regulated kinase 3 isoform 1 [Homo
sapiens]
Length = 496
Score = 47.8 bits (112), Expect = 2e-05
Identities = 33/123 (26%), Positives = 58/123 (47%), Gaps = 17/123 (13%)
Query: 146 TVGITDPEKIGDGMNAYVAYKVTTQTSLPLFRSKQFAVKRRFSDFLGLYEKLSEKHSQNG 205
+V I ++ + + YKV RS+ F V RR+++F LY L ++
Sbjct: 15 SVSIPSSDEHREKKKRFTVYKVLVSVG----RSEWF-VFRRYAEFDKLYNTLKKQFPAMA 69
Query: 206 FIVPPPPEKSLIGMTKVKVGKEDSSSAEFLEKRRAALERYLQRIVNHPTMLQDPDVREFL 265
+P K + G D+ +F+++RRA L ++Q +V +P + PDVR FL
Sbjct: 70 LKIPA---KRIFG---------DNFDPDFIKQRRAGLNEFIQNLVRYPELYNHPDVRAFL 117
Query: 266 EKE 268
+ +
Sbjct: 118 QMD 120
>gi|75813626 serum/glucocorticoid regulated kinase 3 isoform 1 [Homo
sapiens]
Length = 496
Score = 47.8 bits (112), Expect = 2e-05
Identities = 33/123 (26%), Positives = 58/123 (47%), Gaps = 17/123 (13%)
Query: 146 TVGITDPEKIGDGMNAYVAYKVTTQTSLPLFRSKQFAVKRRFSDFLGLYEKLSEKHSQNG 205
+V I ++ + + YKV RS+ F V RR+++F LY L ++
Sbjct: 15 SVSIPSSDEHREKKKRFTVYKVLVSVG----RSEWF-VFRRYAEFDKLYNTLKKQFPAMA 69
Query: 206 FIVPPPPEKSLIGMTKVKVGKEDSSSAEFLEKRRAALERYLQRIVNHPTMLQDPDVREFL 265
+P K + G D+ +F+++RRA L ++Q +V +P + PDVR FL
Sbjct: 70 LKIPA---KRIFG---------DNFDPDFIKQRRAGLNEFIQNLVRYPELYNHPDVRAFL 117
Query: 266 EKE 268
+ +
Sbjct: 118 QMD 120
>gi|4507145 sorting nexin 4 [Homo sapiens]
Length = 450
Score = 45.8 bits (107), Expect = 9e-05
Identities = 85/346 (24%), Positives = 134/346 (38%), Gaps = 59/346 (17%)
Query: 185 RRFSDFLGLYEKLSEKHSQNGFIVPPPPEKSLIGMTKVKVGKEDSSSAEFLEKRRAALER 244
RR+S+F L L + +VPP PEK + D+ +F+E+RR LE
Sbjct: 105 RRYSEFELLRSYLLVYYPH--IVVPPLPEKRAEFVWHKL--SADNMDPDFVERRRIGLEN 160
Query: 245 YLQRIVNHPTMLQDPDVREFLEKE----ELPRAVGTQTLSGAGLLKMFNKATDAVSKMTI 300
+L RI +HP + +D FL +E E G Q L LK N AT V
Sbjct: 161 FLLRIASHPILCRDKIFYLFLTQEGNWKETVNETGFQ-LKADSRLKALN-ATFRVKNPDK 218
Query: 301 KMNESDIWFEEKLQEVECEEQRLR-----KLHAVVETLVNHRK---ELALNTAQFAKSLA 352
+ + + ++LQ V R+R +L+ V + N+ + E + + L
Sbjct: 219 RFTDLK-HYSDELQSVISHLLRVRARVADRLYGVYKVHGNYGRVFSEWSAIEKEMGDGLQ 277
Query: 353 MLGSSEDNTALSRALSQLAEVEEKIEQLHQEQANNDFFLLAELLSDYIRLLAIVR----- 407
G D A S + + E EE H ++ AE L R +++
Sbjct: 278 SAGHHMDVYASS--IDDILEDEE-----HYADQLKEYLFYAEALRAVCRKHELMQYDLEM 330
Query: 408 AAFDQRMKTWQRWQDAQATLQ-----------------KKREAEARLLWANKPDKLQQAK 450
AA D K Q + T++ ++REA ++L + QQ K
Sbjct: 331 AAQDLASKKQQCEELVTGTVRTFSLKGMTTKLFGQETPEQREARIKVLEEQINEGEQQLK 390
Query: 451 DEILEWESRVTQYERDFERISTVVRKEVIRFEKEKSKDFKNHVIKY 496
+ LE V D E RF+++K++D K +I Y
Sbjct: 391 SKNLEGREFVKNAWADIE-----------RFKEQKNRDLKEALISY 425
Database: hs.faa
Posted date: Aug 4, 2009 4:42 PM
Number of letters in database: 18,247,518
Number of sequences in database: 37,866
Lambda K H
0.311 0.128 0.355
Gapped
Lambda K H
0.267 0.0410 0.140
Matrix: BLOSUM62
Gap Penalties: Existence: 11, Extension: 1
Number of Hits to DB: 20,503,175
Number of Sequences: 37866
Number of extensions: 947377
Number of successful extensions: 5360
Number of sequences better than 10.0: 30
Number of HSP's better than 10.0 without gapping: 38
Number of HSP's successfully gapped in prelim test: 281
Number of HSP's that attempted gapping in prelim test: 5038
Number of HSP's gapped (non-prelim): 609
length of query: 522
length of database: 18,247,518
effective HSP length: 107
effective length of query: 415
effective length of database: 14,195,856
effective search space: 5891280240
effective search space used: 5891280240
T: 11
A: 40
X1: 16 ( 7.2 bits)
X2: 38 (14.6 bits)
X3: 64 (24.7 bits)
S1: 42 (21.8 bits)
S2: 64 (29.3 bits)
Search results were obtained with NCBI BLAST and RefSeq entries.
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Guide to the Human Genome
Copyright © 2010 by Stewart Scherer. All rights reserved.