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Search of human proteins with 229892220
BLASTP 2.2.11 [Jun-05-2005]
Reference: Altschul, Stephen F., Thomas L. Madden, Alejandro A. Schaffer,
Jinghui Zhang, Zheng Zhang, Webb Miller, and David J. Lipman (1997),
"Gapped BLAST and PSI-BLAST: a new generation of protein database search
programs", Nucleic Acids Res. 25:3389-3402.
Query= gi|229892220 fms-related tyrosine kinase 1 isoform 2 precursor
[Homo sapiens]
(687 letters)
Database: hs.faa
37,866 sequences; 18,247,518 total letters
Searching..................................................done
Score E
Sequences producing significant alignments: (bits) Value
gi|229892220 fms-related tyrosine kinase 1 isoform 2 precursor [... 1387 0.0
gi|156104876 fms-related tyrosine kinase 1 isoform 1 precursor [... 1322 0.0
gi|229892300 fms-related tyrosine kinase 1 isoform 3 precursor [... 1322 0.0
gi|229892302 fms-related tyrosine kinase 1 isoform 4 precursor [... 1049 0.0
gi|104294888 fms-related tyrosine kinase 4 isoform 1 precursor [... 329 5e-90
gi|103472027 fms-related tyrosine kinase 4 isoform 2 precursor [... 329 5e-90
gi|11321597 kinase insert domain receptor precursor [Homo sapiens] 328 1e-89
gi|5453870 platelet-derived growth factor receptor alpha precurs... 147 4e-35
gi|4505683 platelet-derived growth factor receptor beta precurso... 108 2e-23
gi|148005039 v-kit Hardy-Zuckerman 4 feline sarcoma viral oncoge... 93 7e-19
gi|4557695 v-kit Hardy-Zuckerman 4 feline sarcoma viral oncogene... 93 7e-19
gi|5453872 platelet-derived growth factor receptor-like protein ... 92 2e-18
gi|118572606 hemicentin 1 [Homo sapiens] 86 1e-16
gi|7657359 contactin 5 isoform long [Homo sapiens] 83 7e-16
gi|28373129 contactin 5 isoform short [Homo sapiens] 83 7e-16
gi|21359935 Down syndrome cell adhesion molecule like 1 [Homo sa... 75 2e-13
gi|169177000 PREDICTED: hemicentin 2 [Homo sapiens] 73 1e-12
gi|38490688 immunoglobulin superfamily, member 10 [Homo sapiens] 72 2e-12
gi|169178458 PREDICTED: hemicentin 2 [Homo sapiens] 72 2e-12
gi|239749684 PREDICTED: hemicentin 2 [Homo sapiens] 72 2e-12
gi|157311649 neogenin homolog 1 [Homo sapiens] 72 2e-12
gi|115529482 neural cell adhesion molecule 1 isoform 2 [Homo sap... 71 3e-12
gi|28373122 contactin 4 isoform a precursor [Homo sapiens] 70 8e-12
gi|94420689 neural cell adhesion molecule 1 isoform 1 [Homo sapi... 69 2e-11
gi|115529478 neural cell adhesion molecule 1 isoform 3 [Homo sap... 69 2e-11
gi|239755187 PREDICTED: similar to hemicentin 2 [Homo sapiens] 67 4e-11
gi|27262659 colony stimulating factor 1 receptor precursor [Homo... 65 2e-10
gi|126517478 peroxidasin homolog-like [Homo sapiens] 65 2e-10
gi|20127422 Down syndrome cell adhesion molecule isoform CHD2-42... 65 2e-10
gi|19743806 roundabout 1 isoform b [Homo sapiens] 64 5e-10
>gi|229892220 fms-related tyrosine kinase 1 isoform 2 precursor
[Homo sapiens]
Length = 687
Score = 1387 bits (3589), Expect = 0.0
Identities = 687/687 (100%), Positives = 687/687 (100%)
Query: 1 MVSYWDTGVLLCALLSCLLLTGSSSGSKLKDPELSLKGTQHIMQAGQTLHLQCRGEAAHK 60
MVSYWDTGVLLCALLSCLLLTGSSSGSKLKDPELSLKGTQHIMQAGQTLHLQCRGEAAHK
Sbjct: 1 MVSYWDTGVLLCALLSCLLLTGSSSGSKLKDPELSLKGTQHIMQAGQTLHLQCRGEAAHK 60
Query: 61 WSLPEMVSKESERLSITKSACGRNGKQFCSTLTLNTAQANHTGFYSCKYLAVPTSKKKET 120
WSLPEMVSKESERLSITKSACGRNGKQFCSTLTLNTAQANHTGFYSCKYLAVPTSKKKET
Sbjct: 61 WSLPEMVSKESERLSITKSACGRNGKQFCSTLTLNTAQANHTGFYSCKYLAVPTSKKKET 120
Query: 121 ESAIYIFISDTGRPFVEMYSEIPEIIHMTEGRELVIPCRVTSPNITVTLKKFPLDTLIPD 180
ESAIYIFISDTGRPFVEMYSEIPEIIHMTEGRELVIPCRVTSPNITVTLKKFPLDTLIPD
Sbjct: 121 ESAIYIFISDTGRPFVEMYSEIPEIIHMTEGRELVIPCRVTSPNITVTLKKFPLDTLIPD 180
Query: 181 GKRIIWDSRKGFIISNATYKEIGLLTCEATVNGHLYKTNYLTHRQTNTIIDVQISTPRPV 240
GKRIIWDSRKGFIISNATYKEIGLLTCEATVNGHLYKTNYLTHRQTNTIIDVQISTPRPV
Sbjct: 181 GKRIIWDSRKGFIISNATYKEIGLLTCEATVNGHLYKTNYLTHRQTNTIIDVQISTPRPV 240
Query: 241 KLLRGHTLVLNCTATTPLNTRVQMTWSYPDEKNKRASVRRRIDQSNSHANIFYSVLTIDK 300
KLLRGHTLVLNCTATTPLNTRVQMTWSYPDEKNKRASVRRRIDQSNSHANIFYSVLTIDK
Sbjct: 241 KLLRGHTLVLNCTATTPLNTRVQMTWSYPDEKNKRASVRRRIDQSNSHANIFYSVLTIDK 300
Query: 301 MQNKDKGLYTCRVRSGPSFKSVNTSVHIYDKAFITVKHRKQQVLETVAGKRSYRLSMKVK 360
MQNKDKGLYTCRVRSGPSFKSVNTSVHIYDKAFITVKHRKQQVLETVAGKRSYRLSMKVK
Sbjct: 301 MQNKDKGLYTCRVRSGPSFKSVNTSVHIYDKAFITVKHRKQQVLETVAGKRSYRLSMKVK 360
Query: 361 AFPSPEVVWLKDGLPATEKSARYLTRGYSLIIKDVTEEDAGNYTILLSIKQSNVFKNLTA 420
AFPSPEVVWLKDGLPATEKSARYLTRGYSLIIKDVTEEDAGNYTILLSIKQSNVFKNLTA
Sbjct: 361 AFPSPEVVWLKDGLPATEKSARYLTRGYSLIIKDVTEEDAGNYTILLSIKQSNVFKNLTA 420
Query: 421 TLIVNVKPQIYEKAVSSFPDPALYPLGSRQILTCTAYGIPQPTIKWFWHPCNHNHSEARC 480
TLIVNVKPQIYEKAVSSFPDPALYPLGSRQILTCTAYGIPQPTIKWFWHPCNHNHSEARC
Sbjct: 421 TLIVNVKPQIYEKAVSSFPDPALYPLGSRQILTCTAYGIPQPTIKWFWHPCNHNHSEARC 480
Query: 481 DFCSNNEESFILDADSNMGNRIESITQRMAIIEGKNKMASTLVVADSRISGIYICIASNK 540
DFCSNNEESFILDADSNMGNRIESITQRMAIIEGKNKMASTLVVADSRISGIYICIASNK
Sbjct: 481 DFCSNNEESFILDADSNMGNRIESITQRMAIIEGKNKMASTLVVADSRISGIYICIASNK 540
Query: 541 VGTVGRNISFYITDVPNGFHVNLEKMPTEGEDLKLSCTVNKFLYRDVTWILLRTVNNRTM 600
VGTVGRNISFYITDVPNGFHVNLEKMPTEGEDLKLSCTVNKFLYRDVTWILLRTVNNRTM
Sbjct: 541 VGTVGRNISFYITDVPNGFHVNLEKMPTEGEDLKLSCTVNKFLYRDVTWILLRTVNNRTM 600
Query: 601 HYSISKQKMAITKEHSITLNLTIMNVSLQDSGTYACRARNVYTGEEILQKKEITIRGEHC 660
HYSISKQKMAITKEHSITLNLTIMNVSLQDSGTYACRARNVYTGEEILQKKEITIRGEHC
Sbjct: 601 HYSISKQKMAITKEHSITLNLTIMNVSLQDSGTYACRARNVYTGEEILQKKEITIRGEHC 660
Query: 661 NKKAVFSRISKFKSTRNDCTTQSNVKH 687
NKKAVFSRISKFKSTRNDCTTQSNVKH
Sbjct: 661 NKKAVFSRISKFKSTRNDCTTQSNVKH 687
>gi|156104876 fms-related tyrosine kinase 1 isoform 1 precursor
[Homo sapiens]
Length = 1338
Score = 1322 bits (3422), Expect = 0.0
Identities = 656/658 (99%), Positives = 657/658 (99%)
Query: 1 MVSYWDTGVLLCALLSCLLLTGSSSGSKLKDPELSLKGTQHIMQAGQTLHLQCRGEAAHK 60
MVSYWDTGVLLCALLSCLLLTGSSSGSKLKDPELSLKGTQHIMQAGQTLHLQCRGEAAHK
Sbjct: 1 MVSYWDTGVLLCALLSCLLLTGSSSGSKLKDPELSLKGTQHIMQAGQTLHLQCRGEAAHK 60
Query: 61 WSLPEMVSKESERLSITKSACGRNGKQFCSTLTLNTAQANHTGFYSCKYLAVPTSKKKET 120
WSLPEMVSKESERLSITKSACGRNGKQFCSTLTLNTAQANHTGFYSCKYLAVPTSKKKET
Sbjct: 61 WSLPEMVSKESERLSITKSACGRNGKQFCSTLTLNTAQANHTGFYSCKYLAVPTSKKKET 120
Query: 121 ESAIYIFISDTGRPFVEMYSEIPEIIHMTEGRELVIPCRVTSPNITVTLKKFPLDTLIPD 180
ESAIYIFISDTGRPFVEMYSEIPEIIHMTEGRELVIPCRVTSPNITVTLKKFPLDTLIPD
Sbjct: 121 ESAIYIFISDTGRPFVEMYSEIPEIIHMTEGRELVIPCRVTSPNITVTLKKFPLDTLIPD 180
Query: 181 GKRIIWDSRKGFIISNATYKEIGLLTCEATVNGHLYKTNYLTHRQTNTIIDVQISTPRPV 240
GKRIIWDSRKGFIISNATYKEIGLLTCEATVNGHLYKTNYLTHRQTNTIIDVQISTPRPV
Sbjct: 181 GKRIIWDSRKGFIISNATYKEIGLLTCEATVNGHLYKTNYLTHRQTNTIIDVQISTPRPV 240
Query: 241 KLLRGHTLVLNCTATTPLNTRVQMTWSYPDEKNKRASVRRRIDQSNSHANIFYSVLTIDK 300
KLLRGHTLVLNCTATTPLNTRVQMTWSYPDEKNKRASVRRRIDQSNSHANIFYSVLTIDK
Sbjct: 241 KLLRGHTLVLNCTATTPLNTRVQMTWSYPDEKNKRASVRRRIDQSNSHANIFYSVLTIDK 300
Query: 301 MQNKDKGLYTCRVRSGPSFKSVNTSVHIYDKAFITVKHRKQQVLETVAGKRSYRLSMKVK 360
MQNKDKGLYTCRVRSGPSFKSVNTSVHIYDKAFITVKHRKQQVLETVAGKRSYRLSMKVK
Sbjct: 301 MQNKDKGLYTCRVRSGPSFKSVNTSVHIYDKAFITVKHRKQQVLETVAGKRSYRLSMKVK 360
Query: 361 AFPSPEVVWLKDGLPATEKSARYLTRGYSLIIKDVTEEDAGNYTILLSIKQSNVFKNLTA 420
AFPSPEVVWLKDGLPATEKSARYLTRGYSLIIKDVTEEDAGNYTILLSIKQSNVFKNLTA
Sbjct: 361 AFPSPEVVWLKDGLPATEKSARYLTRGYSLIIKDVTEEDAGNYTILLSIKQSNVFKNLTA 420
Query: 421 TLIVNVKPQIYEKAVSSFPDPALYPLGSRQILTCTAYGIPQPTIKWFWHPCNHNHSEARC 480
TLIVNVKPQIYEKAVSSFPDPALYPLGSRQILTCTAYGIPQPTIKWFWHPCNHNHSEARC
Sbjct: 421 TLIVNVKPQIYEKAVSSFPDPALYPLGSRQILTCTAYGIPQPTIKWFWHPCNHNHSEARC 480
Query: 481 DFCSNNEESFILDADSNMGNRIESITQRMAIIEGKNKMASTLVVADSRISGIYICIASNK 540
DFCSNNEESFILDADSNMGNRIESITQRMAIIEGKNKMASTLVVADSRISGIYICIASNK
Sbjct: 481 DFCSNNEESFILDADSNMGNRIESITQRMAIIEGKNKMASTLVVADSRISGIYICIASNK 540
Query: 541 VGTVGRNISFYITDVPNGFHVNLEKMPTEGEDLKLSCTVNKFLYRDVTWILLRTVNNRTM 600
VGTVGRNISFYITDVPNGFHVNLEKMPTEGEDLKLSCTVNKFLYRDVTWILLRTVNNRTM
Sbjct: 541 VGTVGRNISFYITDVPNGFHVNLEKMPTEGEDLKLSCTVNKFLYRDVTWILLRTVNNRTM 600
Query: 601 HYSISKQKMAITKEHSITLNLTIMNVSLQDSGTYACRARNVYTGEEILQKKEITIRGE 658
HYSISKQKMAITKEHSITLNLTIMNVSLQDSGTYACRARNVYTGEEILQKKEITIR +
Sbjct: 601 HYSISKQKMAITKEHSITLNLTIMNVSLQDSGTYACRARNVYTGEEILQKKEITIRDQ 658
Score = 52.4 bits (124), Expect = 1e-06
Identities = 130/630 (20%), Positives = 225/630 (35%), Gaps = 130/630 (20%)
Query: 32 PELSLKGTQHIMQAGQTLHLQCRGEAAHKWSLPEMVSKE-SERLSITKSACGRNGKQFCS 90
P L+G ++ T L R + WS P+ +K S R I +S N F S
Sbjct: 239 PVKLLRGHTLVLNCTATTPLNTRVQMT--WSYPDEKNKRASVRRRIDQSNSHAN--IFYS 294
Query: 91 TLTLNTAQANHTGFYSCKYLAVPTSKKKETESAIYIFISDTGRPFVEMYSEIPEIIHMTE 150
LT++ Q G Y+C+ + P+ K T IY + F+ + +++
Sbjct: 295 VLTIDKMQNKDKGLYTCRVRSGPSFKSVNTSVHIY------DKAFITVKHRKQQVLETVA 348
Query: 151 GRELVIPCRVTSPNITVTLKKFPLDTLI--PDGKRIIWDSRK------GFIISNATYKEI 202
G+ S +++ +K FP ++ DG S + II + T ++
Sbjct: 349 GKR--------SYRLSMKVKAFPSPEVVWLKDGLPATEKSARYLTRGYSLIIKDVTEEDA 400
Query: 203 GLLTCEATVNGHLYKTNYLTHRQTNTIIDVQ--------ISTPRPVKLLRGHTLVLNCTA 254
G T ++ ++N + I++V+ S P P G +L CTA
Sbjct: 401 GNYTILLSIK----QSNVFKNLTATLIVNVKPQIYEKAVSSFPDPALYPLGSRQILTCTA 456
Query: 255 TTPLNTRVQMTWSYPDEKNKRA------------------SVRRRIDQSNSHANIFYS-- 294
++ W + + A ++ RI+ I
Sbjct: 457 YGIPQPTIKWFWHPCNHNHSEARCDFCSNNEESFILDADSNMGNRIESITQRMAIIEGKN 516
Query: 295 --VLTIDKMQNKDKGLYTCRVRSGPSFKSVNTSVHIYDKAFITVKHRKQQVLETVAGK-R 351
T+ ++ G+Y C + N S +I D V + LE + +
Sbjct: 517 KMASTLVVADSRISGIYICIASNKVGTVGRNISFYITD-----VPNGFHVNLEKMPTEGE 571
Query: 352 SYRLSMKVKAFPSPEVVWL-------KDGLPATEKSARYLTRGYS----LIIKDVTEEDA 400
+LS V F +V W+ + + K +T+ +S L I +V+ +D+
Sbjct: 572 DLKLSCTVNKFLYRDVTWILLRTVNNRTMHYSISKQKMAITKEHSITLNLTIMNVSLQDS 631
Query: 401 GNYTILLSIKQSNVF--KNLTATLIVNVKPQIYEKAVSSFPDPALYPLGSRQILTCTAYG 458
G Y + + NV+ + + + ++ Q + + D + + S L C A G
Sbjct: 632 GTY----ACRARNVYTGEEILQKKEITIRDQEAPYLLRNLSDHTV-AISSSTTLDCHANG 686
Query: 459 IPQPTIKWFWHPCNHNHSEARCDFCSNNEESFILDADSNMGNRIESITQRMAIIEGKNKM 518
+P+P I WF +NH I Q II G
Sbjct: 687 VPEPQITWF----KNNH----------------------------KIQQEPGIILGPGSS 714
Query: 519 ASTLVVADSRISGIYICIASNKVGTVGRNISFYITDVPNGFHVNLEKMPTEGEDLKLSCT 578
+ G+Y C A+N+ G+V S Y+T NLE + L+CT
Sbjct: 715 TLFIERVTEEDEGVYHCKATNQKGSV--ESSAYLTVQGTSDKSNLEL-------ITLTCT 765
Query: 579 VNKFLYRDVTWILLRTVNNRTMHYSISKQK 608
+ + W+LL T+ R M S S+ K
Sbjct: 766 C---VAATLFWLLL-TLFIRKMKRSSSEIK 791
>gi|229892300 fms-related tyrosine kinase 1 isoform 3 precursor
[Homo sapiens]
Length = 733
Score = 1322 bits (3422), Expect = 0.0
Identities = 656/658 (99%), Positives = 657/658 (99%)
Query: 1 MVSYWDTGVLLCALLSCLLLTGSSSGSKLKDPELSLKGTQHIMQAGQTLHLQCRGEAAHK 60
MVSYWDTGVLLCALLSCLLLTGSSSGSKLKDPELSLKGTQHIMQAGQTLHLQCRGEAAHK
Sbjct: 1 MVSYWDTGVLLCALLSCLLLTGSSSGSKLKDPELSLKGTQHIMQAGQTLHLQCRGEAAHK 60
Query: 61 WSLPEMVSKESERLSITKSACGRNGKQFCSTLTLNTAQANHTGFYSCKYLAVPTSKKKET 120
WSLPEMVSKESERLSITKSACGRNGKQFCSTLTLNTAQANHTGFYSCKYLAVPTSKKKET
Sbjct: 61 WSLPEMVSKESERLSITKSACGRNGKQFCSTLTLNTAQANHTGFYSCKYLAVPTSKKKET 120
Query: 121 ESAIYIFISDTGRPFVEMYSEIPEIIHMTEGRELVIPCRVTSPNITVTLKKFPLDTLIPD 180
ESAIYIFISDTGRPFVEMYSEIPEIIHMTEGRELVIPCRVTSPNITVTLKKFPLDTLIPD
Sbjct: 121 ESAIYIFISDTGRPFVEMYSEIPEIIHMTEGRELVIPCRVTSPNITVTLKKFPLDTLIPD 180
Query: 181 GKRIIWDSRKGFIISNATYKEIGLLTCEATVNGHLYKTNYLTHRQTNTIIDVQISTPRPV 240
GKRIIWDSRKGFIISNATYKEIGLLTCEATVNGHLYKTNYLTHRQTNTIIDVQISTPRPV
Sbjct: 181 GKRIIWDSRKGFIISNATYKEIGLLTCEATVNGHLYKTNYLTHRQTNTIIDVQISTPRPV 240
Query: 241 KLLRGHTLVLNCTATTPLNTRVQMTWSYPDEKNKRASVRRRIDQSNSHANIFYSVLTIDK 300
KLLRGHTLVLNCTATTPLNTRVQMTWSYPDEKNKRASVRRRIDQSNSHANIFYSVLTIDK
Sbjct: 241 KLLRGHTLVLNCTATTPLNTRVQMTWSYPDEKNKRASVRRRIDQSNSHANIFYSVLTIDK 300
Query: 301 MQNKDKGLYTCRVRSGPSFKSVNTSVHIYDKAFITVKHRKQQVLETVAGKRSYRLSMKVK 360
MQNKDKGLYTCRVRSGPSFKSVNTSVHIYDKAFITVKHRKQQVLETVAGKRSYRLSMKVK
Sbjct: 301 MQNKDKGLYTCRVRSGPSFKSVNTSVHIYDKAFITVKHRKQQVLETVAGKRSYRLSMKVK 360
Query: 361 AFPSPEVVWLKDGLPATEKSARYLTRGYSLIIKDVTEEDAGNYTILLSIKQSNVFKNLTA 420
AFPSPEVVWLKDGLPATEKSARYLTRGYSLIIKDVTEEDAGNYTILLSIKQSNVFKNLTA
Sbjct: 361 AFPSPEVVWLKDGLPATEKSARYLTRGYSLIIKDVTEEDAGNYTILLSIKQSNVFKNLTA 420
Query: 421 TLIVNVKPQIYEKAVSSFPDPALYPLGSRQILTCTAYGIPQPTIKWFWHPCNHNHSEARC 480
TLIVNVKPQIYEKAVSSFPDPALYPLGSRQILTCTAYGIPQPTIKWFWHPCNHNHSEARC
Sbjct: 421 TLIVNVKPQIYEKAVSSFPDPALYPLGSRQILTCTAYGIPQPTIKWFWHPCNHNHSEARC 480
Query: 481 DFCSNNEESFILDADSNMGNRIESITQRMAIIEGKNKMASTLVVADSRISGIYICIASNK 540
DFCSNNEESFILDADSNMGNRIESITQRMAIIEGKNKMASTLVVADSRISGIYICIASNK
Sbjct: 481 DFCSNNEESFILDADSNMGNRIESITQRMAIIEGKNKMASTLVVADSRISGIYICIASNK 540
Query: 541 VGTVGRNISFYITDVPNGFHVNLEKMPTEGEDLKLSCTVNKFLYRDVTWILLRTVNNRTM 600
VGTVGRNISFYITDVPNGFHVNLEKMPTEGEDLKLSCTVNKFLYRDVTWILLRTVNNRTM
Sbjct: 541 VGTVGRNISFYITDVPNGFHVNLEKMPTEGEDLKLSCTVNKFLYRDVTWILLRTVNNRTM 600
Query: 601 HYSISKQKMAITKEHSITLNLTIMNVSLQDSGTYACRARNVYTGEEILQKKEITIRGE 658
HYSISKQKMAITKEHSITLNLTIMNVSLQDSGTYACRARNVYTGEEILQKKEITIR +
Sbjct: 601 HYSISKQKMAITKEHSITLNLTIMNVSLQDSGTYACRARNVYTGEEILQKKEITIRDQ 658
Score = 47.4 bits (111), Expect = 5e-05
Identities = 98/489 (20%), Positives = 179/489 (36%), Gaps = 85/489 (17%)
Query: 32 PELSLKGTQHIMQAGQTLHLQCRGEAAHKWSLPEMVSKE-SERLSITKSACGRNGKQFCS 90
P L+G ++ T L R + WS P+ +K S R I +S N F S
Sbjct: 239 PVKLLRGHTLVLNCTATTPLNTRVQMT--WSYPDEKNKRASVRRRIDQSNSHAN--IFYS 294
Query: 91 TLTLNTAQANHTGFYSCKYLAVPTSKKKETESAIYIFISDTGRPFVEMYSEIPEIIHMTE 150
LT++ Q G Y+C+ + P+ K T IY + F+ + +++
Sbjct: 295 VLTIDKMQNKDKGLYTCRVRSGPSFKSVNTSVHIY------DKAFITVKHRKQQVLETVA 348
Query: 151 GRELVIPCRVTSPNITVTLKKFPLDTLI--PDGKRIIWDSRK------GFIISNATYKEI 202
G+ S +++ +K FP ++ DG S + II + T ++
Sbjct: 349 GKR--------SYRLSMKVKAFPSPEVVWLKDGLPATEKSARYLTRGYSLIIKDVTEEDA 400
Query: 203 GLLTCEATVNGHLYKTNYLTHRQTNTIIDVQ--------ISTPRPVKLLRGHTLVLNCTA 254
G T ++ ++N + I++V+ S P P G +L CTA
Sbjct: 401 GNYTILLSIK----QSNVFKNLTATLIVNVKPQIYEKAVSSFPDPALYPLGSRQILTCTA 456
Query: 255 TTPLNTRVQMTWSYPDEKNKRA------------------SVRRRIDQSNSHANIFYS-- 294
++ W + + A ++ RI+ I
Sbjct: 457 YGIPQPTIKWFWHPCNHNHSEARCDFCSNNEESFILDADSNMGNRIESITQRMAIIEGKN 516
Query: 295 --VLTIDKMQNKDKGLYTCRVRSGPSFKSVNTSVHIYDKAFITVKHRKQQVLETVAGK-R 351
T+ ++ G+Y C + N S +I D V + LE + +
Sbjct: 517 KMASTLVVADSRISGIYICIASNKVGTVGRNISFYITD-----VPNGFHVNLEKMPTEGE 571
Query: 352 SYRLSMKVKAFPSPEVVWL-------KDGLPATEKSARYLTRGYS----LIIKDVTEEDA 400
+LS V F +V W+ + + K +T+ +S L I +V+ +D+
Sbjct: 572 DLKLSCTVNKFLYRDVTWILLRTVNNRTMHYSISKQKMAITKEHSITLNLTIMNVSLQDS 631
Query: 401 GNYTILLSIKQSNVF--KNLTATLIVNVKPQIYEKAVSSFPDPALYPLGSRQILTCTAYG 458
G Y + + NV+ + + + ++ Q + + D + + S L C A G
Sbjct: 632 GTY----ACRARNVYTGEEILQKKEITIRDQEAPYLLRNLSDHTV-AISSSTTLDCHANG 686
Query: 459 IPQPTIKWF 467
+P+P I WF
Sbjct: 687 VPEPQITWF 695
Score = 38.5 bits (88), Expect = 0.021
Identities = 38/137 (27%), Positives = 54/137 (39%), Gaps = 18/137 (13%)
Query: 245 GHTLVLNCTATTPLNTRVQMTWSYPDEKNKRASVRRRIDQSNSHANIFYSV---LTIDKM 301
G L L+CT L V TW N R ++ I + +S+ LTI +
Sbjct: 570 GEDLKLSCTVNKFLYRDV--TWILLRTVNNR-TMHYSISKQKMAITKEHSITLNLTIMNV 626
Query: 302 QNKDKGLYTCRVRSGPSFKSVNTSVHIYDKAFITVKHRKQQVL------ETVAGKRSYRL 355
+D G Y CR R+ V T I K IT++ ++ L TVA S L
Sbjct: 627 SLQDSGTYACRARN------VYTGEEILQKKEITIRDQEAPYLLRNLSDHTVAISSSTTL 680
Query: 356 SMKVKAFPSPEVVWLKD 372
P P++ W K+
Sbjct: 681 DCHANGVPEPQITWFKN 697
>gi|229892302 fms-related tyrosine kinase 1 isoform 4 precursor
[Homo sapiens]
Length = 541
Score = 1049 bits (2713), Expect = 0.0
Identities = 517/518 (99%), Positives = 518/518 (100%)
Query: 1 MVSYWDTGVLLCALLSCLLLTGSSSGSKLKDPELSLKGTQHIMQAGQTLHLQCRGEAAHK 60
MVSYWDTGVLLCALLSCLLLTGSSSGSKLKDPELSLKGTQHIMQAGQTLHLQCRGEAAHK
Sbjct: 1 MVSYWDTGVLLCALLSCLLLTGSSSGSKLKDPELSLKGTQHIMQAGQTLHLQCRGEAAHK 60
Query: 61 WSLPEMVSKESERLSITKSACGRNGKQFCSTLTLNTAQANHTGFYSCKYLAVPTSKKKET 120
WSLPEMVSKESERLSITKSACGRNGKQFCSTLTLNTAQANHTGFYSCKYLAVPTSKKKET
Sbjct: 61 WSLPEMVSKESERLSITKSACGRNGKQFCSTLTLNTAQANHTGFYSCKYLAVPTSKKKET 120
Query: 121 ESAIYIFISDTGRPFVEMYSEIPEIIHMTEGRELVIPCRVTSPNITVTLKKFPLDTLIPD 180
ESAIYIFISDTGRPFVEMYSEIPEIIHMTEGRELVIPCRVTSPNITVTLKKFPLDTLIPD
Sbjct: 121 ESAIYIFISDTGRPFVEMYSEIPEIIHMTEGRELVIPCRVTSPNITVTLKKFPLDTLIPD 180
Query: 181 GKRIIWDSRKGFIISNATYKEIGLLTCEATVNGHLYKTNYLTHRQTNTIIDVQISTPRPV 240
GKRIIWDSRKGFIISNATYKEIGLLTCEATVNGHLYKTNYLTHRQTNTIIDVQISTPRPV
Sbjct: 181 GKRIIWDSRKGFIISNATYKEIGLLTCEATVNGHLYKTNYLTHRQTNTIIDVQISTPRPV 240
Query: 241 KLLRGHTLVLNCTATTPLNTRVQMTWSYPDEKNKRASVRRRIDQSNSHANIFYSVLTIDK 300
KLLRGHTLVLNCTATTPLNTRVQMTWSYPDEKNKRASVRRRIDQSNSHANIFYSVLTIDK
Sbjct: 241 KLLRGHTLVLNCTATTPLNTRVQMTWSYPDEKNKRASVRRRIDQSNSHANIFYSVLTIDK 300
Query: 301 MQNKDKGLYTCRVRSGPSFKSVNTSVHIYDKAFITVKHRKQQVLETVAGKRSYRLSMKVK 360
MQNKDKGLYTCRVRSGPSFKSVNTSVHIYDKAFITVKHRKQQVLETVAGKRSYRLSMKVK
Sbjct: 301 MQNKDKGLYTCRVRSGPSFKSVNTSVHIYDKAFITVKHRKQQVLETVAGKRSYRLSMKVK 360
Query: 361 AFPSPEVVWLKDGLPATEKSARYLTRGYSLIIKDVTEEDAGNYTILLSIKQSNVFKNLTA 420
AFPSPEVVWLKDGLPATEKSARYLTRGYSLIIKDVTEEDAGNYTILLSIKQSNVFKNLTA
Sbjct: 361 AFPSPEVVWLKDGLPATEKSARYLTRGYSLIIKDVTEEDAGNYTILLSIKQSNVFKNLTA 420
Query: 421 TLIVNVKPQIYEKAVSSFPDPALYPLGSRQILTCTAYGIPQPTIKWFWHPCNHNHSEARC 480
TLIVNVKPQIYEKAVSSFPDPALYPLGSRQILTCTAYGIPQPTIKWFWHPCNHNHSEARC
Sbjct: 421 TLIVNVKPQIYEKAVSSFPDPALYPLGSRQILTCTAYGIPQPTIKWFWHPCNHNHSEARC 480
Query: 481 DFCSNNEESFILDADSNMGNRIESITQRMAIIEGKNKM 518
DFCSNNEESFILDADSNMGNRIESITQRMAIIEGKNK+
Sbjct: 481 DFCSNNEESFILDADSNMGNRIESITQRMAIIEGKNKL 518
>gi|104294888 fms-related tyrosine kinase 4 isoform 1 precursor
[Homo sapiens]
Length = 1363
Score = 329 bits (844), Expect = 5e-90
Identities = 209/692 (30%), Positives = 344/692 (49%), Gaps = 65/692 (9%)
Query: 8 GVLLCALL-SCL-LLTGSSSGSKLKDPELSLKGTQHIMQAGQTLHLQCRGEAAHKWS--- 62
G LC L CL LL G SG + P L++ H++ G +L + CRG+ +W+
Sbjct: 4 GAALCLRLWLCLGLLDGLVSGYSMTPPTLNITEESHVIDTGDSLSISCRGQHPLEWAWPG 63
Query: 63 ---LPEMVSKESERLSITKSACGRNGKQFCSTLTLNTAQANHTGFYSCKYLAVPTSKKKE 119
P K+SE + + G + + +C L L+ AN TG Y C Y + +
Sbjct: 64 AQEAPATGDKDSEDTGVVRDCEGTDARPYCKVLLLHEVHANDTGSYVCYYKYIKARIEGT 123
Query: 120 TESAIYIFISDTGRPFVEMYSEIPEIIHMTEGRELVIPCRVTSPNITVTLKKFPLDTLIP 179
T ++ Y+F+ D +PF+ P+ + + + +PC V+ P + VTL+ L P
Sbjct: 124 TAASSYVFVRDFEQPFINK----PDTLLVNRKDAMWVPCLVSIPGLNVTLRS-QSSVLWP 178
Query: 180 DGKRIIWDSRKGFIISNATYKEIGLLTCEATVNGHLYKTN-YLTHRQTNTIIDVQISTPR 238
DG+ ++WD R+G ++S + L CE T + +N +L H N + D+Q+ +
Sbjct: 179 DGQEVVWDDRRGMLVSTPLLHDALYLQCETTWGDQDFLSNPFLVHITGNELYDIQLLPRK 238
Query: 239 PVKLLRGHTLVLNCTATTPLNTRVQMTWSYPDEKNKRAS--VRRRIDQSNSHANIFYSVL 296
++LL G LVLNCT N+ V W YP ++ +R RR Q+++ + S+L
Sbjct: 239 SLELLVGEKLVLNCTVWAEFNSGVTFDWDYPGKQAERGKWVPERRSQQTHTELS---SIL 295
Query: 297 TIDKMQNKDKGLYTCRVRSGPSFKSVNTSVHIYDKAFITVKHRKQQVLETVAGKRSYRLS 356
TI + D G Y C+ +G +T V +++ FI+V+ K +LE AG +L
Sbjct: 296 TIHNVSQHDLGSYVCKANNGIQRFRESTEVIVHENPFISVEWLKGPILEATAGDELVKLP 355
Query: 357 MKVKAFPSPEVVWLKDGLPATEKSARYLTRGYSLIIKDVTEEDAGNYTILLSIKQSNVFK 416
+K+ A+P PE W KDG + + + + +L++K+VTE G YT+ L + + +
Sbjct: 356 VKLAAYPPPEFQWYKDGKALSGRHSPH-----ALVLKEVTEASTGTYTLALWNSAAGLRR 410
Query: 417 NLTATLIVNVKPQIYEKAVSSFPDPALYPLGSRQILTCTAYGIPQP-TIKWFWHPCNHNH 475
N++ L+VNV PQI+EK SS P++Y SRQ LTCTAYG+P P +I+W W P
Sbjct: 411 NISLELVVNVPPQIHEKEASS---PSIYSRHSRQALTCTAYGVPLPLSIQWHWRPWTPCK 467
Query: 476 SEARCDFCSNNEESFILDA-------DSNMGNRIESITQRMAIIEGKNKMASTLVVADSR 528
A+ ++ + + N IES+ +EGKNK S LV+ ++
Sbjct: 468 MFAQRSLRRRQQQDLMPQCRDWRAVTTQDAVNPIESLDTWTEFVEGKNKTVSKLVIQNAN 527
Query: 529 ISGIYICIASNKVGTVGRNISFYITDVPNGFHVNLEKMPT----EGEDLKLSCTVNKFLY 584
+S +Y C+ SNKVG R I FY+T +P+GF +E P+ EG+ + LSC + + Y
Sbjct: 528 VSAMYKCVVSNKVGQDERLIYFYVTTIPDGF--TIESKPSEELLEGQPVLLSCQADSYKY 585
Query: 585 RDVTWILLRTVNNRTMH--------------------YSISKQKMAITKEHSITLNLTIM 624
+ W L N T+H + S +++A H+ TL+L+I
Sbjct: 586 EHLRWYRL---NLSTLHDAHGNPLLLDCKNVHLFATPLAASLEEVAPGARHA-TLSLSIP 641
Query: 625 NVSLQDSGTYACRARNVYTGEEILQKKEITIR 656
V+ + G Y C ++ + ++ KK ++++
Sbjct: 642 RVAPEHEGHYVCEVQDRRSHDKHCHKKYLSVQ 673
Score = 33.5 bits (75), Expect = 0.67
Identities = 34/130 (26%), Positives = 54/130 (41%), Gaps = 3/130 (2%)
Query: 296 LTIDKMQNKDKGLYTCRVRSGPSFKSVNTSVHIYDKAFITVKHRKQQVLETVAGKRSYRL 355
L+I ++ + +G Y C V+ S ++ +A + + V S +
Sbjct: 638 LSIPRVAPEHEGHYVCEVQDRRSHDKHCHKKYLSVQALEAPRLTQNLTDLLVNVSDSLEM 697
Query: 356 SMKVKAFPSPEVVWLKDGLPATEKSARYLT-RGYSLIIKDVTEEDAGNYTILLSIKQSNV 414
V +P +VW KD EKS L L I+ V EEDAG Y L S+ +
Sbjct: 698 QCLVAGAHAPSIVWYKDERLLEEKSGVDLADSNQKLSIQRVREEDAGRY--LCSVCNAKG 755
Query: 415 FKNLTATLIV 424
N +A++ V
Sbjct: 756 CVNSSASVAV 765
>gi|103472027 fms-related tyrosine kinase 4 isoform 2 precursor
[Homo sapiens]
Length = 1298
Score = 329 bits (844), Expect = 5e-90
Identities = 209/692 (30%), Positives = 344/692 (49%), Gaps = 65/692 (9%)
Query: 8 GVLLCALL-SCL-LLTGSSSGSKLKDPELSLKGTQHIMQAGQTLHLQCRGEAAHKWS--- 62
G LC L CL LL G SG + P L++ H++ G +L + CRG+ +W+
Sbjct: 4 GAALCLRLWLCLGLLDGLVSGYSMTPPTLNITEESHVIDTGDSLSISCRGQHPLEWAWPG 63
Query: 63 ---LPEMVSKESERLSITKSACGRNGKQFCSTLTLNTAQANHTGFYSCKYLAVPTSKKKE 119
P K+SE + + G + + +C L L+ AN TG Y C Y + +
Sbjct: 64 AQEAPATGDKDSEDTGVVRDCEGTDARPYCKVLLLHEVHANDTGSYVCYYKYIKARIEGT 123
Query: 120 TESAIYIFISDTGRPFVEMYSEIPEIIHMTEGRELVIPCRVTSPNITVTLKKFPLDTLIP 179
T ++ Y+F+ D +PF+ P+ + + + +PC V+ P + VTL+ L P
Sbjct: 124 TAASSYVFVRDFEQPFINK----PDTLLVNRKDAMWVPCLVSIPGLNVTLRS-QSSVLWP 178
Query: 180 DGKRIIWDSRKGFIISNATYKEIGLLTCEATVNGHLYKTN-YLTHRQTNTIIDVQISTPR 238
DG+ ++WD R+G ++S + L CE T + +N +L H N + D+Q+ +
Sbjct: 179 DGQEVVWDDRRGMLVSTPLLHDALYLQCETTWGDQDFLSNPFLVHITGNELYDIQLLPRK 238
Query: 239 PVKLLRGHTLVLNCTATTPLNTRVQMTWSYPDEKNKRAS--VRRRIDQSNSHANIFYSVL 296
++LL G LVLNCT N+ V W YP ++ +R RR Q+++ + S+L
Sbjct: 239 SLELLVGEKLVLNCTVWAEFNSGVTFDWDYPGKQAERGKWVPERRSQQTHTELS---SIL 295
Query: 297 TIDKMQNKDKGLYTCRVRSGPSFKSVNTSVHIYDKAFITVKHRKQQVLETVAGKRSYRLS 356
TI + D G Y C+ +G +T V +++ FI+V+ K +LE AG +L
Sbjct: 296 TIHNVSQHDLGSYVCKANNGIQRFRESTEVIVHENPFISVEWLKGPILEATAGDELVKLP 355
Query: 357 MKVKAFPSPEVVWLKDGLPATEKSARYLTRGYSLIIKDVTEEDAGNYTILLSIKQSNVFK 416
+K+ A+P PE W KDG + + + + +L++K+VTE G YT+ L + + +
Sbjct: 356 VKLAAYPPPEFQWYKDGKALSGRHSPH-----ALVLKEVTEASTGTYTLALWNSAAGLRR 410
Query: 417 NLTATLIVNVKPQIYEKAVSSFPDPALYPLGSRQILTCTAYGIPQP-TIKWFWHPCNHNH 475
N++ L+VNV PQI+EK SS P++Y SRQ LTCTAYG+P P +I+W W P
Sbjct: 411 NISLELVVNVPPQIHEKEASS---PSIYSRHSRQALTCTAYGVPLPLSIQWHWRPWTPCK 467
Query: 476 SEARCDFCSNNEESFILDA-------DSNMGNRIESITQRMAIIEGKNKMASTLVVADSR 528
A+ ++ + + N IES+ +EGKNK S LV+ ++
Sbjct: 468 MFAQRSLRRRQQQDLMPQCRDWRAVTTQDAVNPIESLDTWTEFVEGKNKTVSKLVIQNAN 527
Query: 529 ISGIYICIASNKVGTVGRNISFYITDVPNGFHVNLEKMPT----EGEDLKLSCTVNKFLY 584
+S +Y C+ SNKVG R I FY+T +P+GF +E P+ EG+ + LSC + + Y
Sbjct: 528 VSAMYKCVVSNKVGQDERLIYFYVTTIPDGF--TIESKPSEELLEGQPVLLSCQADSYKY 585
Query: 585 RDVTWILLRTVNNRTMH--------------------YSISKQKMAITKEHSITLNLTIM 624
+ W L N T+H + S +++A H+ TL+L+I
Sbjct: 586 EHLRWYRL---NLSTLHDAHGNPLLLDCKNVHLFATPLAASLEEVAPGARHA-TLSLSIP 641
Query: 625 NVSLQDSGTYACRARNVYTGEEILQKKEITIR 656
V+ + G Y C ++ + ++ KK ++++
Sbjct: 642 RVAPEHEGHYVCEVQDRRSHDKHCHKKYLSVQ 673
Score = 33.5 bits (75), Expect = 0.67
Identities = 34/130 (26%), Positives = 54/130 (41%), Gaps = 3/130 (2%)
Query: 296 LTIDKMQNKDKGLYTCRVRSGPSFKSVNTSVHIYDKAFITVKHRKQQVLETVAGKRSYRL 355
L+I ++ + +G Y C V+ S ++ +A + + V S +
Sbjct: 638 LSIPRVAPEHEGHYVCEVQDRRSHDKHCHKKYLSVQALEAPRLTQNLTDLLVNVSDSLEM 697
Query: 356 SMKVKAFPSPEVVWLKDGLPATEKSARYLT-RGYSLIIKDVTEEDAGNYTILLSIKQSNV 414
V +P +VW KD EKS L L I+ V EEDAG Y L S+ +
Sbjct: 698 QCLVAGAHAPSIVWYKDERLLEEKSGVDLADSNQKLSIQRVREEDAGRY--LCSVCNAKG 755
Query: 415 FKNLTATLIV 424
N +A++ V
Sbjct: 756 CVNSSASVAV 765
>gi|11321597 kinase insert domain receptor precursor [Homo sapiens]
Length = 1356
Score = 328 bits (841), Expect = 1e-89
Identities = 222/672 (33%), Positives = 339/672 (50%), Gaps = 41/672 (6%)
Query: 9 VLLCALLSCLLLTGSSSGS---KLKDPELSLKGTQHIMQAGQTLHLQCRGEAAHKWSLPE 65
+L AL C+ +S G L P LS++ ++A TL + CRG+ W P
Sbjct: 6 LLAVALWLCVETRAASVGLPSVSLDLPRLSIQKDILTIKANTTLQITCRGQRDLDWLWPN 65
Query: 66 MVSKESERLSITKSACGRNGKQFCSTLTLNTAQANHTGFYSCKYLAVPTSKKKETESAIY 125
S +R+ +T+ + G FC TLT+ N TG Y C Y ++ + S IY
Sbjct: 66 NQSGSEQRVEVTECSDGL----FCKTLTIPKVIGNDTGAYKCFY------RETDLASVIY 115
Query: 126 IFISDTGRPFVEMYSEIPEIIHMTEGRE--LVIPCRVTSPNITVTL-KKFPLDTLIPDGK 182
+++ D PF+ S+ ++++TE + +VIPC + N+ V+L ++P +PDG
Sbjct: 116 VYVQDYRSPFIASVSDQHGVVYITENKNKTVVIPCLGSISNLNVSLCARYPEKRFVPDGN 175
Query: 183 RIIWDSRKGFIISNATYKEIGLLTCEATVNGHLYKT-NYLTHRQTNTIIDVQISTPRPVK 241
RI WDS+KGF I + G++ CEA +N Y++ Y+ I DV +S ++
Sbjct: 176 RISWDSKKGFTIPSYMISYAGMVFCEAKINDESYQSIMYIVVVVGYRIYDVVLSPSHGIE 235
Query: 242 LLRGHTLVLNCTATTPLNTRVQMTWSYPDEKNKRASVRRRI--DQSNSHANIFYSVLTID 299
L G LVLNCTA T LN + W YP K++ + R QS S F S LTID
Sbjct: 236 LSVGEKLVLNCTARTELNVGIDFNWEYPSSKHQHKKLVNRDLKTQSGSEMKKFLSTLTID 295
Query: 300 KMQNKDKGLYTCRVRSGPSFKSVNTSVHIYDKAFITVKHRKQQVLETVAGKRSYRLSMKV 359
+ D+GLYTC SG K +T V +++K F+ + ++E G+R R+ K
Sbjct: 296 GVTRSDQGLYTCAASSGLMTKKNSTFVRVHEKPFVAFGSGMESLVEATVGER-VRIPAKY 354
Query: 360 KAFPSPEVVWLKDGLPATEKSARYLTRGYSLIIKDVTEEDAGNYTILLSIKQSNVFKNLT 419
+P PE+ W K+G+P +S + G+ L I +V+E D GNYT++L+ S ++
Sbjct: 355 LGYPPPEIKWYKNGIPL--ESNHTIKAGHVLTIMEVSERDTGNYTVILTNPISKEKQSHV 412
Query: 420 ATLIVNVKPQIYEKAVSSFPDPALYPLGSRQILTCTAYGIPQPT-IKWFWH---PCNHNH 475
+L+V V PQI EK++ S D Y G+ Q LTCT Y IP P I W+W C +
Sbjct: 413 VSLVVYVPPQIGEKSLISPVDS--YQYGTTQTLTCTVYAIPPPHHIHWYWQLEEECANEP 470
Query: 476 SEARCDFCSNNEESFILDADSNMGNRIESITQRMAIIEGKNKMASTLVVADSRISGIYIC 535
S+A E + D GN+IE + A+IEGKNK STLV+ + +S +Y C
Sbjct: 471 SQAVSVTNPYPCEEWRSVEDFQGGNKIEVNKNQFALIEGKNKTVSTLVIQAANVSALYKC 530
Query: 536 IASNKVGTVGRNISFYITDVPNGFHVNLEKMPTEGEDLKLSCTVNKFLYRDVTWILL--- 592
A NKVG R ISF++T P + + PTE E + L CT ++ + ++TW L
Sbjct: 531 EAVNKVGRGERVISFHVTRGPE-ITLQPDMQPTEQESVSLWCTADRSTFENLTWYKLGPQ 589
Query: 593 -RTVNNRTMHYSISKQ-----KMAITKEHSITLNLTIM---NVSLQDSGTYACRARNVYT 643
++ + + K K+ T + T ++ IM N SLQD G Y C A++ T
Sbjct: 590 PLPIHVGELPTPVCKNLDTLWKLNATMFSNSTNDILIMELKNASLQDQGDYVCLAQDRKT 649
Query: 644 GEEILQKKEITI 655
+ +++T+
Sbjct: 650 KKRHCVVRQLTV 661
Score = 35.8 bits (81), Expect = 0.14
Identities = 31/123 (25%), Positives = 54/123 (43%), Gaps = 7/123 (5%)
Query: 285 SNSHANIFYSVLTIDKMQNKDKGLYTCRVRSGPSFKS--VNTSVHIYDKAFITVKHRKQQ 342
SNS +I ++ + +D+G Y C + + K V + + ++ T+ +
Sbjct: 618 SNSTNDIL--IMELKNASLQDQGDYVCLAQDRKTKKRHCVVRQLTVLERVAPTITGNLEN 675
Query: 343 VLETVAGKRSYRLSMKVKAFPSPEVVWLKDGLPATEKSARYLTRG-YSLIIKDVTEEDAG 401
+T + S +S P P+++W KD E S L G +L I+ V +ED G
Sbjct: 676 --QTTSIGESIEVSCTASGNPPPQIMWFKDNETLVEDSGIVLKDGNRNLTIRRVRKEDEG 733
Query: 402 NYT 404
YT
Sbjct: 734 LYT 736
Score = 34.7 bits (78), Expect = 0.30
Identities = 51/215 (23%), Positives = 79/215 (36%), Gaps = 43/215 (20%)
Query: 441 PALYPLGSRQI-LTCTAYGIPQPTIKWFW---HPCNHNHSEARCDFCSNNEESFILDADS 496
P + P + L CTA + W+ P + E C N + + L+A
Sbjct: 557 PDMQPTEQESVSLWCTADRSTFENLTWYKLGPQPLPIHVGELPTPVCKNLDTLWKLNA-- 614
Query: 497 NMGNRIESITQRMAIIEGKNKMASTLVVADSRISGIYICIASN----KVGTVGRNISFYI 552
+ T + I+E KN A + G Y+C+A + K V R ++
Sbjct: 615 ---TMFSNSTNDILIMELKN--------ASLQDQGDYVCLAQDRKTKKRHCVVRQLTVLE 663
Query: 553 TDVPNGFHVNLEKMPTE-GEDLKLSCTVNKFLYRDVTWILLRTVNNRTMHYSISKQKMAI 611
P NLE T GE +++SCT + + W K +
Sbjct: 664 RVAPT-ITGNLENQTTSIGESIEVSCTASGNPPPQIMWF---------------KDNETL 707
Query: 612 TKEHSITL-----NLTIMNVSLQDSGTYACRARNV 641
++ I L NLTI V +D G Y C+A +V
Sbjct: 708 VEDSGIVLKDGNRNLTIRRVRKEDEGLYTCQACSV 742
>gi|5453870 platelet-derived growth factor receptor alpha precursor
[Homo sapiens]
Length = 1089
Score = 147 bits (370), Expect = 4e-35
Identities = 155/557 (27%), Positives = 242/557 (43%), Gaps = 74/557 (13%)
Query: 14 LLSCLLLTGSSSGSKLKDPELSLKGTQHIMQAGQTLHLQCRGEAAHKWSLPEMVSKESER 73
+L CLL S +L P + + ++Q + L+C GE+ W P M +ES
Sbjct: 10 VLGCLLTGLSLILCQLSLPSILPNENEKVVQLNSSFSLRCFGESEVSWQYP-MSEEESSD 68
Query: 74 LSITKSACGRNGKQFCSTLTLNTAQANHTGFYSCKYLAVPTSKKKETESAIYIFISDTGR 133
+ I N F + L +++A A HTG Y+C Y T + + IYI++ D
Sbjct: 69 VEIRNEE--NNSGLFVTVLEVSSASAAHTGLYTCYYNHTQTEENELEGRHIYIYVPDPDV 126
Query: 134 PFVEMYSEIPEIIHMTEGRELVIPCRVTSPNITVTLKKFPLDTLIPDGKRIIWDSRKGFI 193
FV + ++ + + +IPCR T P VTL + ++P +DSR+GF
Sbjct: 127 AFVPL-GMTDYLVIVEDDDSAIIPCRTTDPETPVTLHN--SEGVVPAS----YDSRQGF- 178
Query: 194 ISNATYKEIGLLTCEATVNGHLYKT---NYLTHRQTNTIIDVQISTPRPVKLLRGHTLVL 250
N T+ +G CEATV G ++T N + T+ +D+++ + V G T+V+
Sbjct: 179 --NGTF-TVGPYICEATVKGKKFQTIPFNVYALKATSE-LDLEMEALKTV-YKSGETIVV 233
Query: 251 NCTATTPLNTRVQMTWSYPDE-KNKRASVRRRIDQSNSHANIFYSVLTIDKMQNKDKGLY 309
C N V + W+YP E K K ++ I + + Y+ LT+ + KD G Y
Sbjct: 234 TCAVFN--NEVVDLQWTYPGEVKGKGITMLEEIKVPS--IKLVYT-LTVPEATVKDSGDY 288
Query: 310 TCRVRSG----PSFKSVNTSVHIYDKAFITVKHRKQQVLETVAGKRSYRLSMKVKAFPSP 365
C R K V SVH +K FI +K Q LE V ++V+A+P P
Sbjct: 289 ECAARQATREVKEMKKVTISVH--EKGFIEIKPTFSQ-LEAVNLHEVKHFVVEVRAYPPP 345
Query: 366 EVVWLKDGLPATEKSARYLT----------RGYSLIIKDVTEEDAGNYTILLSIKQSNVF 415
+ WLK+ L E T R +I+ EED+G+YTI+ + +
Sbjct: 346 RISWLKNNLTLIENLTEITTDVEKIQEIRYRSKLKLIR-AKEEDSGHYTIV--AQNEDAV 402
Query: 416 KNLTATLIVNVKPQIYEKAVSSFPDPALYPLGSRQILTCTAYGIPQPTIKWFWHPCNHNH 475
K+ T L+ V I + + Q + CTA G P P I+W C
Sbjct: 403 KSYTFELLTQVPSSILDLVDDH------HGSTGGQTVRCTAEGTPLPDIEWM--ICK--- 451
Query: 476 SEARCDFCSNNEESFILDADSNMGNRIESITQR-MAIIEGK---NKMASTLVVADSRISG 531
+C NNE S+ + A +N+ N I I R + +EG+ K+ T+ V
Sbjct: 452 DIKKC----NNETSWTILA-NNVSNIITEIHSRDRSTVEGRVTFAKVEETIAVR------ 500
Query: 532 IYICIASNKVGTVGRNI 548
C+A N +G R +
Sbjct: 501 ---CLAKNLLGAENREL 514
Score = 35.0 bits (79), Expect = 0.23
Identities = 33/130 (25%), Positives = 55/130 (42%), Gaps = 12/130 (9%)
Query: 531 GIYICIASNKVGTVGRNISF--YITDVPNGFHVNLEKMPT---EGEDLKLSCTVNKFLYR 585
G YIC A+ K G + I F Y + + +E + T GE + ++C V
Sbjct: 185 GPYICEATVK-GKKFQTIPFNVYALKATSELDLEMEALKTVYKSGETIVVTCAVFNNEVV 243
Query: 586 DVTWILLRTVNNRTMHYSISKQKMAITKEHSITLNLTIMNVSLQDSGTYACRARNVYTGE 645
D+ W V + I+ + + LT+ +++DSG Y C AR
Sbjct: 244 DLQWTYPGEVKGK----GITMLEEIKVPSIKLVYTLTVPEATVKDSGDYECAARQ--ATR 297
Query: 646 EILQKKEITI 655
E+ + K++TI
Sbjct: 298 EVKEMKKVTI 307
>gi|4505683 platelet-derived growth factor receptor beta precursor
[Homo sapiens]
Length = 1106
Score = 108 bits (269), Expect = 2e-23
Identities = 127/478 (26%), Positives = 205/478 (42%), Gaps = 62/478 (12%)
Query: 8 GVLLCALLSCLLLTGSSSGSKLKDPELSLKGTQHIMQAGQTLHLQCRGEAAHKWSLPEMV 67
G LL L LL S G + P G + ++ T L C G A W E +
Sbjct: 14 GELLLLSLLLLLEPQISQGLVVTPP-----GPELVLNVSSTFVLTCSGSAPVVW---ERM 65
Query: 68 SKESERLSITKSACGRNGKQFCSTLTLNTAQANHTGFYSCKYLAVPTSKKKETESA--IY 125
S+E + + A ++G F S LTL TG Y C + S+ ET+ +Y
Sbjct: 66 SQEPPQ----EMAKAQDGT-FSSVLTLTNLTGLDTGEYFCTH---NDSRGLETDERKRLY 117
Query: 126 IFISDTGRPFVEMYSEIPEIIHMTEGRELVIPCRVTSPNITVTLKKFPLDTLIPDGKRII 185
IF+ D F+ +E I +TE E+ IPCRVT P + VTL + D +P +
Sbjct: 118 IFVPDPTVGFLPNDAE-ELFIFLTEITEITIPCRVTDPQLVVTLHEKKGDVALP----VP 172
Query: 186 WDSRKGF--IISNATYKEIGLLTCEATVNGHLYKTN-YLTHRQTNTIIDVQISTPRPVKL 242
+D ++GF I + +Y C+ T+ ++ Y +R + I+V ++ + V +
Sbjct: 173 YDHQRGFSGIFEDRSY------ICKTTIGDREVDSDAYYVYRLQVSSINVSVNAVQTV-V 225
Query: 243 LRGHTLVLNCTATTPLNTRVQMTWSYPDEKNKRASVRRRIDQSNSHANIFYSVLTIDKMQ 302
+G + L C N V W+YP +++ R V D S+L I +
Sbjct: 226 RQGENITLMCIVIG--NEVVNFEWTYPRKESGRL-VEPVTDFLLDMPYHIRSILHIPSAE 282
Query: 303 NKDKGLYTCRVRSG----PSFKSVNTSVHIYDKAFITVKHRKQQVLETVAGKRSYRLSMK 358
+D G YTC V K++N + + + ++ + + L+ RS L +
Sbjct: 283 LEDSGTYTCNVTESVNDHQDEKAIN--ITVVESGYVRLL-GEVGTLQFAELHRSRTLQVV 339
Query: 359 VKAFPSPEVVWLKDGLPATEKSARYL---TRGYS-------LIIKDVTEEDAGNYTILLS 408
+A+P P V+W KD + SA + TR S L + V +AG+YT+
Sbjct: 340 FEAYPPPTVLWFKDNRTLGDSSAGEIALSTRNVSETRYVSELTLVRVKVAEAGHYTMRAF 399
Query: 409 IKQSNVFKNLTATLIVNVKPQIYEKAVSSFPDPALYPLGSRQILTCTAYGIPQPTIKW 466
+ + V L+ L +NV ++ E + S +P Q + C G+PQP I W
Sbjct: 400 HEDAEV--QLSFQLQINVPVRVLELSES-------HPDSGEQTVRCRGRGMPQPNIIW 448
>gi|148005039 v-kit Hardy-Zuckerman 4 feline sarcoma viral oncogene
homolog isoform 2 precursor [Homo sapiens]
Length = 972
Score = 93.2 bits (230), Expect = 7e-19
Identities = 122/500 (24%), Positives = 207/500 (41%), Gaps = 81/500 (16%)
Query: 5 WDTGVLLCALLSCLLL-TGSSSGS----KLKDPELSLKGTQHIMQAGQTLHLQCRGEAAH 59
WD LC LL L + TGSS S + P + + I++ G + L C
Sbjct: 8 WD---FLCVLLLLLRVQTGSSQPSVSPGEPSPPSIHPGKSDLIVRVGDEIRLLCTDPGFV 64
Query: 60 KWSLPEMVSKESERLSITKSACGRNGKQFCSTLTLNTAQANHTGFYSCKYLAVPTSKKKE 119
KW+ E++ + +E KQ + A+A +TG Y+C + K
Sbjct: 65 KWTF-EILDETNEN------------KQ--NEWITEKAEATNTGKYTC-------TNKHG 102
Query: 120 TESAIYIFISDTGRPFVEMYSEIPEIIHMTEGRELVIPCRVTSPNITVTLKKFPLDTLIP 179
++IY+F+ D + F+ + ++ E + ++ C +T P +T K +P
Sbjct: 103 LSNSIYVFVRDPAKLFL-----VDRSLYGKEDNDTLVRCPLTDPEVTNYSLKGCQGKPLP 157
Query: 180 DGKRIIWDSRKGFIISNA--TYKEIGLLTCEATVNGH--LYKTNYLTHRQTNTIIDVQIS 235
R I D + G +I + Y + L C G L + L R + V +S
Sbjct: 158 KDLRFIPDPKAGIMIKSVKRAYHRL-CLHCSVDQEGKSVLSEKFILKVRPAFKAVPV-VS 215
Query: 236 TPRPVKLLR-GHTLVLNCTATTPLNTRVQMTWSYPDEKNKRASVRRRIDQSNSHANIFY- 293
+ LLR G + CT +++ V TW +N + ++ + + S H + Y
Sbjct: 216 VSKASYLLREGEEFTVTCTIKD-VSSSVYSTWK---RENSQTKLQEKYN-SWHHGDFNYE 270
Query: 294 --SVLTIDKMQNKDKGLYTCRVRSGPSFKSVNTSVHIYDKAFITVKHRKQQVLETVAGKR 351
+ LTI + D G++ C + +V T++ + DK FI + + G+
Sbjct: 271 RQATLTISSARVNDSGVFMCYANNTFGSANVTTTLEVVDKGFINIFPMINTTVFVNDGE- 329
Query: 352 SYRLSMKVKAFPSPE-VVWLKDGLPATEKSARYLTRGYSLIIKDVTE--------EDAGN 402
+ L ++ +AFP PE W+ T+K Y I+ V+E + G
Sbjct: 330 NVDLIVEYEAFPKPEHQQWIYMNRTFTDKWEDYPKSENESNIRYVSELHLTRLKGTEGGT 389
Query: 403 YTILLSIKQSNVFKNLTATLIVNVKPQI--YEKAVSSFPDPALYPLGSRQILTCTAYGIP 460
YT L+S S+V + + VN KP+I Y++ V+ +L C A G P
Sbjct: 390 YTFLVS--NSDVNAAIAFNVYVNTKPEILTYDRLVNG-------------MLQCVAAGFP 434
Query: 461 QPTIKWFWHPCNHNHSEARC 480
+PTI W++ P +E RC
Sbjct: 435 EPTIDWYFCP----GTEQRC 450
Score = 30.4 bits (67), Expect = 5.7
Identities = 23/96 (23%), Positives = 41/96 (42%), Gaps = 16/96 (16%)
Query: 569 EGEDLKLSCT---VNKFLY----RDVTWILLRTVNNRTMHYSISKQKMAITKEHSITLNL 621
EGE+ ++CT V+ +Y R+ + L+ N H + ++ A L
Sbjct: 225 EGEEFTVTCTIKDVSSSVYSTWKRENSQTKLQEKYNSWHHGDFNYERQA---------TL 275
Query: 622 TIMNVSLQDSGTYACRARNVYTGEEILQKKEITIRG 657
TI + + DSG + C A N + + E+ +G
Sbjct: 276 TISSARVNDSGVFMCYANNTFGSANVTTTLEVVDKG 311
>gi|4557695 v-kit Hardy-Zuckerman 4 feline sarcoma viral oncogene
homolog isoform 1 precursor [Homo sapiens]
Length = 976
Score = 93.2 bits (230), Expect = 7e-19
Identities = 122/500 (24%), Positives = 207/500 (41%), Gaps = 81/500 (16%)
Query: 5 WDTGVLLCALLSCLLL-TGSSSGS----KLKDPELSLKGTQHIMQAGQTLHLQCRGEAAH 59
WD LC LL L + TGSS S + P + + I++ G + L C
Sbjct: 8 WD---FLCVLLLLLRVQTGSSQPSVSPGEPSPPSIHPGKSDLIVRVGDEIRLLCTDPGFV 64
Query: 60 KWSLPEMVSKESERLSITKSACGRNGKQFCSTLTLNTAQANHTGFYSCKYLAVPTSKKKE 119
KW+ E++ + +E KQ + A+A +TG Y+C + K
Sbjct: 65 KWTF-EILDETNEN------------KQ--NEWITEKAEATNTGKYTC-------TNKHG 102
Query: 120 TESAIYIFISDTGRPFVEMYSEIPEIIHMTEGRELVIPCRVTSPNITVTLKKFPLDTLIP 179
++IY+F+ D + F+ + ++ E + ++ C +T P +T K +P
Sbjct: 103 LSNSIYVFVRDPAKLFL-----VDRSLYGKEDNDTLVRCPLTDPEVTNYSLKGCQGKPLP 157
Query: 180 DGKRIIWDSRKGFIISNA--TYKEIGLLTCEATVNGH--LYKTNYLTHRQTNTIIDVQIS 235
R I D + G +I + Y + L C G L + L R + V +S
Sbjct: 158 KDLRFIPDPKAGIMIKSVKRAYHRL-CLHCSVDQEGKSVLSEKFILKVRPAFKAVPV-VS 215
Query: 236 TPRPVKLLR-GHTLVLNCTATTPLNTRVQMTWSYPDEKNKRASVRRRIDQSNSHANIFY- 293
+ LLR G + CT +++ V TW +N + ++ + + S H + Y
Sbjct: 216 VSKASYLLREGEEFTVTCTIKD-VSSSVYSTWK---RENSQTKLQEKYN-SWHHGDFNYE 270
Query: 294 --SVLTIDKMQNKDKGLYTCRVRSGPSFKSVNTSVHIYDKAFITVKHRKQQVLETVAGKR 351
+ LTI + D G++ C + +V T++ + DK FI + + G+
Sbjct: 271 RQATLTISSARVNDSGVFMCYANNTFGSANVTTTLEVVDKGFINIFPMINTTVFVNDGE- 329
Query: 352 SYRLSMKVKAFPSPE-VVWLKDGLPATEKSARYLTRGYSLIIKDVTE--------EDAGN 402
+ L ++ +AFP PE W+ T+K Y I+ V+E + G
Sbjct: 330 NVDLIVEYEAFPKPEHQQWIYMNRTFTDKWEDYPKSENESNIRYVSELHLTRLKGTEGGT 389
Query: 403 YTILLSIKQSNVFKNLTATLIVNVKPQI--YEKAVSSFPDPALYPLGSRQILTCTAYGIP 460
YT L+S S+V + + VN KP+I Y++ V+ +L C A G P
Sbjct: 390 YTFLVS--NSDVNAAIAFNVYVNTKPEILTYDRLVNG-------------MLQCVAAGFP 434
Query: 461 QPTIKWFWHPCNHNHSEARC 480
+PTI W++ P +E RC
Sbjct: 435 EPTIDWYFCP----GTEQRC 450
Score = 30.4 bits (67), Expect = 5.7
Identities = 23/96 (23%), Positives = 41/96 (42%), Gaps = 16/96 (16%)
Query: 569 EGEDLKLSCT---VNKFLY----RDVTWILLRTVNNRTMHYSISKQKMAITKEHSITLNL 621
EGE+ ++CT V+ +Y R+ + L+ N H + ++ A L
Sbjct: 225 EGEEFTVTCTIKDVSSSVYSTWKRENSQTKLQEKYNSWHHGDFNYERQA---------TL 275
Query: 622 TIMNVSLQDSGTYACRARNVYTGEEILQKKEITIRG 657
TI + + DSG + C A N + + E+ +G
Sbjct: 276 TISSARVNDSGVFMCYANNTFGSANVTTTLEVVDKG 311
>gi|5453872 platelet-derived growth factor receptor-like protein
[Homo sapiens]
Length = 375
Score = 91.7 bits (226), Expect = 2e-18
Identities = 79/297 (26%), Positives = 141/297 (47%), Gaps = 27/297 (9%)
Query: 45 AGQTLHLQCRGEAAHKWSLPEMVSK-ESERLSITKSACGRNGKQFCSTLTLNTAQANHTG 103
AGQT+ L+C+G WS P + + RLS+ ++ R G+ LTL + + TG
Sbjct: 88 AGQTVELRCKGSRIG-WSYPAYLDTFKDSRLSVKQNE--RYGQ-----LTLVNSTSADTG 139
Query: 104 FYSC--KYLAVPTSKKKETES-AIYIFISDTGRPFVEMYSEIPEIIHMTEGRELVIPCRV 160
+SC + + +K E ++ + YIF ++ G FV S +++++ R+ V+PCRV
Sbjct: 140 EFSCWVQLCSGYICRKDEAKTGSTYIFFTEKGELFVPSPSYF-DVVYLNPDRQAVVPCRV 198
Query: 161 TSPNITVTL-KKFPLDTLIPDGKRIIWDSRKGFIISNATYKEIGLLTCEATVNGH----- 214
T + VTL ++FP + +G I++D ++GF+ + G++ C A G
Sbjct: 199 TVLSAKVTLHREFPAKEIPANGTDIVYDMKRGFVYLQPHSEHQGVVYCRAEAGGRSQISV 258
Query: 215 LYKTNYLTHRQTNTIIDVQISTPRPVKLLRGHTLVLNCTATTPLNTRVQMTWSYPDEKNK 274
Y+ Y+ + S+ K+ G + + CT + V+ TW +P +K++
Sbjct: 259 KYQLLYVAVPSGPPSTTILASSN---KVKSGDDISVLCTVLGEPDVEVEFTWIFPGQKDE 315
Query: 275 R----ASVRRRIDQSNSH-ANIFYSVLTIDKMQNKDKGLYTCRVRSGPSFKSVNTSV 326
R R I + H I SV+T++ + D G Y C ++ +V T+V
Sbjct: 316 RPVTIQDTWRLIHRGLGHTTRISQSVITVEDFETIDAGYYICTAQNLQGQTTVATTV 372
>gi|118572606 hemicentin 1 [Homo sapiens]
Length = 5635
Score = 85.5 bits (210), Expect = 1e-16
Identities = 134/569 (23%), Positives = 212/569 (37%), Gaps = 79/569 (13%)
Query: 92 LTLNTAQANHTGFYSCKYLAVPTSKKKETESAIYIFISDTGRPFVEMYSEIPEIIHMTEG 151
L ++ A+ + YSC V + KKE +YI RP + P I +T G
Sbjct: 2254 LQISIAEKSDAALYSCVASNVAGTAKKEYNLQVYI------RPTITNSGSHPTEIIVTRG 2307
Query: 152 RELVIPCRVTS-PNITVTLKKFPLDTLIPDGKRIIWDSRKGFIISNATYKEIGLLTCEAT 210
+ + + C V P TVT K + G I+ D + N + G C A
Sbjct: 2308 KSISLECEVQGIPPPTVTWMKDGHPLIKAKGVEIL-DEGHILQLKNIHVSDTGRYVCVAV 2366
Query: 211 -VNGHLYKTNYLTHRQTNTIIDVQISTPRPVKLLRGHTLVLNCTAT-TPLNTRVQMTWSY 268
V G K L+ +II S P + ++ +++ L C A+ PL + +TW +
Sbjct: 2367 NVAGMTDKKYDLSVHAPPSIIGNHRS-PENISVVEKNSVSLTCEASGIPLPS---ITW-F 2421
Query: 269 PDEKNKRASVRRRIDQSNSHANIFYSVLTIDKMQNKDKGLYTCRVRSGPSFKSVNTSVHI 328
D S RI + + + +D G YTC VR+ + + +
Sbjct: 2422 KDGWPVSLSNSVRILSGGRMLRLMQTTM-------EDAGQYTCVVRNAAGEERKIFGLSV 2474
Query: 329 YDKAFITVKHRKQQVLETVAGKRSYRLSMKVKAFPSPEVVWLKDGLPATEKSARY-LTRG 387
I ++ + V V K+S L+ +V P PE+ W KDG P E A + ++ G
Sbjct: 2475 LVPPHIVGENTLEDV--KVKEKQSVTLTCEVTGNPVPEITWHKDGQPLQEDEAHHIISGG 2532
Query: 388 YSLIIKDVTEEDAGNYTILLSIKQSNVFKNLTATLIVNVKPQIYEKAVSSFPDPALYPLG 447
L I +V G YT L S + K+ + +L V V P I P+ L
Sbjct: 2533 RFLQITNVQVPHTGRYTCLASSPAGH--KSRSFSLNVFVSPTIAGVGSDGNPEDVTVILN 2590
Query: 448 SRQILTCTAYGIPQPTIKWFWHPCNHNHSEARCDFCSNNEESFILDADSNMGNRIESITQ 507
S L C AY P TI WF G +ES +
Sbjct: 2591 SPTSLVCEAYSYPPATITWF-----------------------------KDGTPLES-NR 2620
Query: 508 RMAIIEGKNKMASTLVVADSRISGIYICIASNKVGTVGRN--ISFYITDVPN-------G 558
+ I+ G + ++ A +G Y C+A+N+ G + ++ + YI + N G
Sbjct: 2621 NIRILPGGRTL--QILNAQEDNAGRYSCVATNEAGEMIKHYEVKVYIPPIINKGDLWGPG 2678
Query: 559 FHVNLEKMPTEGEDLKLSCTVNKFLYRDVTWILLRTVNNRTMHYSISKQKMAITKEHSIT 618
K+ L L C ++W H +I+ H+
Sbjct: 2679 LSPKEVKIKV-NNTLTLECEAYAIPSASLSWYKDGQPLKSDDHVNIA------ANGHT-- 2729
Query: 619 LNLTIMNVSLQDSGTYACRARNVYTGEEI 647
L I + D+G Y C A N+ +E+
Sbjct: 2730 --LQIKEAQISDTGRYTCVASNIAGEDEL 2756
Score = 82.8 bits (203), Expect = 1e-15
Identities = 113/463 (24%), Positives = 176/463 (38%), Gaps = 74/463 (15%)
Query: 180 DGKRIIWDSRKGFIISNATYKEIGLLTCEATVNGHLYKTNYLTHRQTNTIIDVQISTPRP 239
DG RI+ S I G TC A + H +I Q P
Sbjct: 3942 DGYRIL--SSGAIEILATQLNHAGRYTCVARNAAGSAHRHVTLHVHEPPVIQPQ---PSE 3996
Query: 240 VKLLRGHTLVLNCTATTPLNTRVQMTWSYPDEKNKRASVRRRIDQSNSHANIFYSVLTID 299
+ ++ + ++L C AT + + TW + N S R +HA + L I
Sbjct: 3997 LHVILNNPILLPCEATGTPSPFI--TWQ-KEGINVNTSGR-------NHAVLPSGGLQIS 4046
Query: 300 KMQNKDKGLYTCRVRS--GPSFKSVNTSVHIYDKAFITVKHRKQQVLETVAGKRSYRLSM 357
+ +D G Y C ++ G + + +V + + H K+ V +A + LS
Sbjct: 4047 RAVREDAGTYMCVAQNPAGTALGKIKLNVQVPP---VISPHLKEYV---IAVDKPITLSC 4100
Query: 358 KVKAFPSPEVVWLKDGLPATEKSARYLTRGYSLIIKDVTEEDAGNYTILLSIKQSNVFKN 417
+ P P++ W KDG E + + SL I V DAG+YT + + + +
Sbjct: 4101 EADGLPPPDITWHKDGRAIVESIRQRVLSSGSLQIAFVQPGDAGHYTCMAANVAGS--SS 4158
Query: 418 LTATLIVNVKPQIYEKAVSSFPDPALYPLGSRQILTCTAYGIPQPTIKWFWHPCNHNHSE 477
+ L V+V P+I S S+ IL C A GIP P I W
Sbjct: 4159 TSTKLTVHVPPRI-----RSTEGHYTVNENSQAILPCVADGIPTPAINW----------- 4202
Query: 478 ARCDFCSNNEESFILDADSNMGNRIESITQRMAIIEGKNKMASTLVVADSRISGIYICIA 537
+++ +L +N+ + + I+E +V+ D SG Y C+A
Sbjct: 4203 --------KKDNVLL---ANLLGKYTAEPYGELILE-------NVVLED---SGFYTCVA 4241
Query: 538 SNKVGTVGRNISFYITDVPNGFHVNLEKMPTEGEDLKLSCTVNKFLYRDVTWILLRTVNN 597
+N G +S + +P + + +GE L+LSC +TW T NN
Sbjct: 4242 NNAAGEDTHTVSLTVHVLPTFTELPGDVSLNKGEQLRLSCKATGIPLPKLTW----TFNN 4297
Query: 598 RTMHYSISKQKMAITKEHSITLNLTIMNVSLQDSGTYACRARN 640
+I HS L I VS +DSGTY C A N
Sbjct: 4298 -----NIIPAHFDSVNGHS---ELVIERVSKEDSGTYVCTAEN 4332
Score = 79.3 bits (194), Expect = 1e-14
Identities = 111/449 (24%), Positives = 173/449 (38%), Gaps = 76/449 (16%)
Query: 91 TLTLNTAQANHTGFYSCKYLAVPTSKKKETESAIYIFISDTGRPFVEMYSEIPEIIHMTE 150
+L + Q G Y+C V S T+ +++ P I TE
Sbjct: 4132 SLQIAFVQPGDAGHYTCMAANVAGSSSTSTKLTVHV----------------PPRIRSTE 4175
Query: 151 GR-------ELVIPC---RVTSPNITVTLKKFPLDTLIPDGKRIIWDSRKGFIISNATYK 200
G + ++PC + +P I L L+ GK + I+ N +
Sbjct: 4176 GHYTVNENSQAILPCVADGIPTPAINWKKDNVLLANLL--GKYTA-EPYGELILENVVLE 4232
Query: 201 EIGLLTCEAT-VNGHLYKTNYLTHRQTNTIIDVQISTPRPVKLLRGHTLVLNCTAT-TPL 258
+ G TC A G T LT T ++ P V L +G L L+C AT PL
Sbjct: 4233 DSGFYTCVANNAAGEDTHTVSLTVHVLPTFTEL----PGDVSLNKGEQLRLSCKATGIPL 4288
Query: 259 NTRVQMTWSYPDEKNKRASVRRRIDQSNSHANIFYSVLTIDKMQNKDKGLYTCRVRSGPS 318
++TW++ + + D N H S L I+++ +D G Y C +
Sbjct: 4289 P---KLTWTFNNN-----IIPAHFDSVNGH-----SELVIERVSKEDSGTYVCTAENSVG 4335
Query: 319 FKSVNTSVHIYDKAFITVKHRKQQVLETVAGKRSYRLSMKVKAFPSPEVVWLKDGLPAT- 377
F V++ + + + E + G L+ +VK P+P + W + G+
Sbjct: 4336 FVKAIGFVYVKEPPVFKGDYPSNWI-EPLGGNAI--LNCEVKGDPTPTIQWNRKGVDIEI 4392
Query: 378 EKSARYLTRGYSLIIKDVTEEDAGNYTILLSIKQSNVFKNLTATLIVNVKPQIYEKAVSS 437
R L G SL I EDAG+YT + + + V ++++ TL P I ++
Sbjct: 4393 SHRIRQLGNG-SLAIYGTVNEDAGDYTCVATNEAGVVERSMSLTL---QSPPI----ITL 4444
Query: 438 FPDPALYPLGSRQILTCTAYGIPQPTIKWFWHPCNHNHS---EARCDFCSNNEESFILDA 494
P + G + IL C A G PQPTI W HS + R + SNN +I DA
Sbjct: 4445 EPVETVINAGGKIILNCQATGEPQPTITW----SRQGHSISWDDRVNVLSNN-SLYIADA 4499
Query: 495 DSNMGNRIESITQRMAIIEGKNKMASTLV 523
+ E + +N M S LV
Sbjct: 4500 QKEDTSEFECV--------ARNLMGSVLV 4520
Score = 73.2 bits (178), Expect = 8e-13
Identities = 89/424 (20%), Positives = 152/424 (35%), Gaps = 60/424 (14%)
Query: 234 ISTPRPVKLLRGHTLVLNCTATTPLNTRVQMTWSYPDEKNKRASVRRRIDQSNSHANIFY 293
I P V + G VL C + ++ +TW D + A R +N
Sbjct: 523 IQVPNNVTVTPGERAVLTCLIISAVD--YNLTWQRNDRDVRLAEPARIRTLANLS----- 575
Query: 294 SVLTIDKMQNKDKGLYTCRVRSGPSFKSVNTSVHIYDKAFITVKHRKQQVLETVAGKRSY 353
L + ++ D G Y C V S + + + + + +TV + Q + G
Sbjct: 576 --LELKSVKFNDAGEYHCMVSSEGGSSAASVFLTVQEPPKVTVMPKNQ----SFTGGSEV 629
Query: 354 RLSMKVKAFPSPEVVWLKDGLPATEKSARYLTRGYSLIIKDVTEEDAGNYTILLSIKQSN 413
+ +P P++ W + + +T +L IK+ +DAG Y L S
Sbjct: 630 SIMCSATGYPKPKIAWTVNDMFIVGSHRYRMTSDGTLFIKNAAPKDAGIYGCLASNSAGT 689
Query: 414 VFKNLTATLIVNVKPQIYEKAVSSFPDPALYPLGSRQILTCTAYGIPQPTIKWFWHPCNH 473
+N T I K + + + L LG ++ C GIP P +KWF
Sbjct: 690 DKQNSTLRYIEAPKLMVVQSEL-------LVALGDITVMECKTSGIPPPQVKWF-----K 737
Query: 474 NHSEARCDFCSNNEESFILDADSNMGNRIESITQRMAIIEGKNKMASTLVVADSRISGIY 533
E R +F++ I+ + + I E ++ A G Y
Sbjct: 738 GDLELR-------PSTFLI---------IDPLLGLLKIQETQDLDA-----------GDY 770
Query: 534 ICIASNKVGTVGRNISFYITDVPNGFHVNLEKMPTEGEDLKLSCTVNKFLYRDVTWILLR 593
C+A N+ G I+ + P + G ++ L C V + + W L
Sbjct: 771 TCVAINEAGRATGKITLDVGSPPVFIQEPADVSMEIGSNVTLPCYVQGYPEPTIKWRRLD 830
Query: 594 TVNNRTMHYSISKQKMAITKEHSITLNLTIMNVSLQDSGTYACRARNVYTGEEILQKKEI 653
+ + +S+S T L I+N+ D GTY C A N + +I + +
Sbjct: 831 NMPIFSRPFSVSSISQLRTGA------LFILNLWASDKGTYICEAENQF--GKIQSETTV 882
Query: 654 TIRG 657
T+ G
Sbjct: 883 TVTG 886
Score = 72.0 bits (175), Expect = 2e-12
Identities = 139/632 (21%), Positives = 220/632 (34%), Gaps = 135/632 (21%)
Query: 92 LTLNTAQANHTGFYSCKYLAVPTSKKKETESAIYIFISDTGRPFVEMYSEIPEIIHMTEG 151
L + AQ ++TG Y C KKE E +++ P S + E + + +
Sbjct: 1790 LVIAQAQVSNTGLYRCMAANTAGDHKKEFEVTVHV-------PPTIKSSGLSERV-VVKY 1841
Query: 152 RELVIPCRVTS-PNITVTLKKFPLDTLIPDGKRIIWDSRKGFIISNATYKEIGLLTCEAT 210
+ + + C PN ++T K G I S + I+ ++ G TC AT
Sbjct: 1842 KPVALQCIANGIPNPSITWLKDDQPVNTAQGNLKIQSSGRVLQIAKTLLEDAGRYTCVAT 1901
Query: 211 VNGHLYKTNYLTHRQTNTIIDVQISTPRPV----KLLRGHTLVLN-----CTATTPLNTR 261
+T I + + P + K+L LV N C A N
Sbjct: 1902 NAAG----------ETQQHIQLHVHEPPSLEDAGKMLNETVLVSNPVQLECKAAG--NPV 1949
Query: 262 VQMTWSYPDEKNKRASVRRRIDQSNSHANIFYSVLTIDKMQNKDKGLYTCRVRSGPSFKS 321
+TW Y D + S ++ I+ Q D G+Y C +
Sbjct: 1950 PVITW-YKDNRLLSGSTSMTFLNRGQ-------IIDIESAQISDAGIYKCVAINSAGATE 2001
Query: 322 VNTSVHIYDKAFITVKHRKQQVLETVAGKRSYRLSMKVKAFPSPEVVWLKDGLPATEKS- 380
+ S+ ++ I+ + + V RL + + P+P + WLKDG P + S
Sbjct: 2002 LFYSLQVHVAPSISGSNN----MVAVVVNNPVRLECEARGIPAPSLTWLKDGSPVSSFSN 2057
Query: 381 -ARYLTRGYSLIIKDVTEEDAGNYTILLSIKQSNVFKNLTATLIVNVKPQIY--EKAVSS 437
+ L+ G L + D G YT + K L V V P I E+ VS
Sbjct: 2058 GLQVLSGGRILALTSAQISDTGRYTCVAVNAAGE--KQRDIDLRVYVPPNIMGEEQNVSV 2115
Query: 438 FPDPALYPLGSRQILTCTAYGIPQPTIKWF--WHP--------CNHNHSEARCDFCSNNE 487
A+ L C + IP PT+ W HP + N S + + +
Sbjct: 2116 LISQAVE-------LLCQSDAIPPPTLTWLKDGHPLLKKPGLSISENRSVLKIEDAQVQD 2168
Query: 488 ESFILDADSNMGNRIE-----------------SITQRMAIIEG---------------- 514
+N+ + E +TQ + +IEG
Sbjct: 2169 TGRYTCEATNVAGKTEKNYNVNIWVPPNIGGSDELTQ-LTVIEGNLISLLCESSGIPPPN 2227
Query: 515 ---KNKMASTLVVADSRI------------------SGIYICIASNKVGTVGR--NISFY 551
K K + L + R+ + +Y C+ASN GT + N+ Y
Sbjct: 2228 LIWKKKGSPVLTDSMGRVRILSGGRQLQISIAEKSDAALYSCVASNVAGTAKKEYNLQVY 2287
Query: 552 I--TDVPNGFHVNLEKMPTEGEDLKLSCTVNKFLYRDVTWILLRTVNNRTMHYSISKQKM 609
I T +G H E + T G+ + L C V VTW+ + H I + +
Sbjct: 2288 IRPTITNSGSHPT-EIIVTRGKSISLECEVQGIPPPTVTWM-------KDGHPLIKAKGV 2339
Query: 610 AITKEHSITLNLTIMNVSLQDSGTYACRARNV 641
I E I L + N+ + D+G Y C A NV
Sbjct: 2340 EILDEGHI---LQLKNIHVSDTGRYVCVAVNV 2368
Score = 70.1 bits (170), Expect = 6e-12
Identities = 121/559 (21%), Positives = 202/559 (36%), Gaps = 84/559 (15%)
Query: 92 LTLNTAQANHTGFYSCKYLAVPTSKKKETESAIYIFISDTGRPFVEMYSEIPEIIHMTEG 151
L + A+ + TG Y C+ + V K +Y+ S G E+I T
Sbjct: 3115 LHIKKAEVSDTGQYVCRAINVAGRDDKNFHLNVYVPPSIEGPE--------REVIVETIS 3166
Query: 152 RELVIPCRVTS-PNITVTLKKFPLDTLIPDGKRI-IWDSRKGFIISNATYKEIGLLTCEA 209
+ + C T P T+ K D + I I+ + + + G TC A
Sbjct: 3167 NPVTLTCDATGIPPPTIAWLKNHKRIENSDSLEVRILSGGSKLQIARSQHSDSGNYTCIA 3226
Query: 210 T-VNGHLYKTNYLTHRQTNTIIDVQISTPRPVKLLRGHTLVLNCTAT---TPLNTRVQMT 265
+ + G K +L+ + ++ +I P V +L G + L C A TPL +
Sbjct: 3227 SNMEGKAQKYYFLSIQVPPSVAGAEI--PSDVSVLLGENVELVCNANGIPTPL-----IQ 3279
Query: 266 WSYPDEKNKRASVRR-RIDQSNSHANIFYSVLTIDKMQNKDKGLYTCRVRSGPSFKSVNT 324
W + R R+ + S NI Y LT D G YTC + +
Sbjct: 3280 WLKDGKPIASGETERIRVSANGSTLNI-YGALT------SDTGKYTCVATNPAGEEDRIF 3332
Query: 325 SVHIYDKAFITVKHRKQQVLETVAGKRSYRLSMKVKAFPSPEVVWLKDGLPATEKS-ARY 383
++++Y I + + L T+ S + + P P++ WLK+GLP S R
Sbjct: 3333 NLNVYVTPTIRGNKDEAEKLMTLVDT-SINIECRATGTPPPQINWLKNGLPLPLSSHIRL 3391
Query: 384 LTRGYSLIIKDVTEEDAGNYTILLSIKQ--SNVFKNLTATLIVNVKPQIYEKAVSSFPDP 441
L G + I D YT + S + N NL N+ + + ++
Sbjct: 3392 LAAGQVIRIVRAQVSDVAVYTCVASNRAGVDNKHYNLQVFAPPNMDNSMGTEEITVLK-- 3449
Query: 442 ALYPLGSRQILTCTAYGIPQPTIKWFWHPCNHNHSEARCDFCSNNEESFILDADSNMGNR 501
GS + C G P P++ W + + LDA +
Sbjct: 3450 -----GSSTSMACITDGTPAPSMAWL-----------------RDGQPLGLDAHLTVST- 3486
Query: 502 IESITQRMAIIEGKNKMASTLVVADSRISGIYICIASNKVGTVGRNISFYITDVP--NGF 559
+ M L+ A++ SG Y CIASN+ G V ++ + + P NG
Sbjct: 3487 --------------HGMVLQLLKAETEDSGKYTCIASNEAGEVSKHFILKVLEPPHINGS 3532
Query: 560 HVNLEKMPTEGEDLKLSCTVNKFLYRDVTWILLRTVNNRTMHYSISKQKMAITKEHSITL 619
+ E L+L+C + +TW+ + R + + Q + +
Sbjct: 3533 EEHEEISVIVNNPLELTCIASGIPAPKMTWM----KDGRPLPQTDQVQTLGGGEV----- 3583
Query: 620 NLTIMNVSLQDSGTYACRA 638
L I ++D+G Y C A
Sbjct: 3584 -LRISTAQVEDTGRYTCLA 3601
Score = 68.9 bits (167), Expect = 1e-11
Identities = 122/574 (21%), Positives = 198/574 (34%), Gaps = 83/574 (14%)
Query: 92 LTLNTAQANHTGFYSCKYLAVPTSKKKETESAIYIFISDTGRPFVEMYSEIPEIIHMTEG 151
L L A+ N G Y C + K+ + IYI S G S + + E
Sbjct: 1510 LHLKNARRNDKGRYQCTVSNAAGKQAKDIKLTIYIPPSIKGGNVTTDISVLINSLIKLEC 1569
Query: 152 RELVIPCRVTSPNITVTLKKFPLDTLIPDGKRIIWDSRKGFI-------ISNATYKEIGL 204
+P P T DG+ I+ S+ +I I A +
Sbjct: 1570 ETRGLP--------------MPAITWYKDGQPIMSSSQALYIDKGQYLHIPRAQVSDSAT 1615
Query: 205 LTCEATVNGHLYKTNYLTHRQTNTIIDVQISTPRPVKLLRGHTLVLNCTATTPLNTRVQM 264
TC + ++ +I+ ++TP +++ H+L L C A N +
Sbjct: 1616 YTCHVANVAGTAEKSFHVDVYVPPMIEGNLATPLNKQVVIAHSLTLECKAAG--NPSPIL 1673
Query: 265 TWSYPDEKNKRASVRRRIDQSNSHANIFYSVLTIDKMQNKDKGLYTCRVRSGPSFKSVNT 324
TW D +A+ RI+ L I Q D+G Y C S K +
Sbjct: 1674 TW-LKDGVPVKANDNIRIEAGGKK-------LEIMSAQEIDRGQYICVATSVAGEKEIKY 1725
Query: 325 SVHIYDKAFITVKHRKQQVLETVAGKRSYRLSMKVKAFPSPEVVWLKDGLPATEKSA-RY 383
V + I + V L V P P ++WLKDG E+ +
Sbjct: 1726 EVDVLVPPAIEGGDETSYFIVMV--NNLLELDCHVTGSPPPTIMWLKDGQLIDERDGFKI 1783
Query: 384 LTRGYSLIIKDVTEEDAGNYTILLSIKQSNVFKNLTATLIVNVKPQIYEKAVSSFPDPAL 443
L G L+I + G Y + + + K T V+V P I +S
Sbjct: 1784 LLNGRKLVIAQAQVSNTGLYRCMAANTAGDHKKEFEVT--VHVPPTIKSSGLSERVVVKY 1841
Query: 444 YPLGSRQILTCTAYGIPQPTIKWFWHPCNHNHSEARCDFCSNNEESFILDADSNMGNRIE 503
P+ L C A GIP P+I W ++ + A N+ +I+
Sbjct: 1842 KPVA----LQCIANGIPNPSITWL------------------KDDQPVNTAQGNL--KIQ 1877
Query: 504 SITQRMAIIEGKNKMASTLVVADSRISGIYICIASNKVGTVGRNISFYITDVPNGFHVN- 562
S + + I A TL+ +G Y C+A+N G ++I ++ + P+
Sbjct: 1878 SSGRVLQI-------AKTLL----EDAGRYTCVATNAAGETQQHIQLHVHEPPSLEDAGK 1926
Query: 563 -LEKMPTEGEDLKLSCTVNKFLYRDVTWILLRTVNNRTMHYSISKQKMAITKEHSITLNL 621
L + ++L C +TW +NR + S S M I +
Sbjct: 1927 MLNETVLVSNPVQLECKAAGNPVPVITWY----KDNRLLSGSTS---MTFLNRGQI---I 1976
Query: 622 TIMNVSLQDSGTYACRARNVYTGEEILQKKEITI 655
I + + D+G Y C A N E+ ++ +
Sbjct: 1977 DIESAQISDAGIYKCVAINSAGATELFYSLQVHV 2010
Score = 68.6 bits (166), Expect = 2e-11
Identities = 115/509 (22%), Positives = 180/509 (35%), Gaps = 72/509 (14%)
Query: 143 PEIIHMTEGRELVIPCRVTSPNITVTLKKFPLDTLIPDGKRIIWDSRKGFIISNATYKEI 202
P+ + + G+ + IPC + V T++ DG+ + + I AT +
Sbjct: 1177 PKHLKVQVGQRVDIPCNAQGTPLPVITWSKGGSTMLVDGEHHVSNPDGTLSIDQATPSDA 1236
Query: 203 GLLTCEATVNGHLYKTNYLTHRQTNTIIDVQISTPRPVKL---LRGHTLVLNCTAT-TPL 258
G+ TC AT +T H Q ++ + P + + C A TP
Sbjct: 1237 GIYTCVATNIAGTDETEITLHVQEPPTVE-DLEPPYNTTFQERVANQRIEFPCPAKGTPK 1295
Query: 259 NTRVQMTWSYPDEKNKRASVRRRIDQSNSHANIFYSVLTIDKMQNKDKGLYTCRV--RSG 316
T + W + N R R S ++L I + D G Y C +G
Sbjct: 1296 PT---IKWLH----NGRELTGREPGISILEDG---TLLVIASVTPYDNGEYICVAVNEAG 1345
Query: 317 PSFKSVNTSVHIYDKAFITVKHRKQQVLETVAGKRSYRLSMKVKAFPSPEVVWLKDGLPA 376
+ + N VH+ +K ++Q +V + L +V+ PSP ++W KD +
Sbjct: 1346 TTERKYNLKVHVPP----VIKDKEQVTNVSVLLNQLTNLFCEVEGTPSPIIMWYKDNVQV 1401
Query: 377 TEKSA-RYLTRGYSLIIKDVTEEDAGNYTILLSIKQSNVFKNLTATLIVNVKPQIYEKAV 435
TE S + + G L + T EDAG Y S K N+ T+ N+ + +
Sbjct: 1402 TESSTIQTVNNGKILKLFRATPEDAGRY----SCKAINIAG--TSQKYFNIDVLVPPTII 1455
Query: 436 -SSFPDPALYPLGSRQILTCTAYGIPQPTIKWFWHPCNHNHSEARCDFCSNNEESFILDA 494
++FP+ L L C G P P I WF + + F+
Sbjct: 1456 GTNFPNEVSVVLNRDVALECQVKGTPFPDIHWF----------------KDGKPLFL--G 1497
Query: 495 DSNMGNRIESITQRMAIIEGKNKMASTLVVADSRISGIYICIASNKVGTVGRNI--SFYI 552
D N+ + R ++ KN A G Y C SN G ++I + YI
Sbjct: 1498 DPNV-----ELLDRGQVLHLKN--------ARRNDKGRYQCTVSNAAGKQAKDIKLTIYI 1544
Query: 553 TDVPNGFHVNLEKMPTEGEDLKLSCTVNKFLYRDVTWILLRTVNNRTMHYSISKQKMAIT 612
G +V + +KL C +TW S Q + I
Sbjct: 1545 PPSIKGGNVTTDISVLINSLIKLECETRGLPMPAITWY------KDGQPIMSSSQALYID 1598
Query: 613 KEHSITLNLTIMNVSLQDSGTYACRARNV 641
K L I + DS TY C NV
Sbjct: 1599 KGQ----YLHIPRAQVSDSATYTCHVANV 1623
Score = 68.2 bits (165), Expect = 2e-11
Identities = 97/397 (24%), Positives = 158/397 (39%), Gaps = 45/397 (11%)
Query: 84 NGKQFCS---TLTLNTAQANHTGFYSCKYLAVPTSKKKETESAIYIFISDTGRPFVEMYS 140
NG Q S L L +AQ + TG Y+C + K+++ + +Y+ P M
Sbjct: 2057 NGLQVLSGGRILALTSAQISDTGRYTCVAVNAAGEKQRDIDLRVYV-------PPNIMGE 2109
Query: 141 EIPEIIHMTEGRELVIPCRVTSPNITVTLKKFPLDTLIPDGKRIIWDSRKGFIISNATYK 200
E + +++ EL+ P LK L+ I ++R I +A +
Sbjct: 2110 EQNVSVLISQAVELLCQSDAIPPPTLTWLKDG--HPLLKKPGLSISENRSVLKIEDAQVQ 2167
Query: 201 EIGLLTCEATVNGHLYKTNYLTHRQTNTIIDVQISTP---RPVKLLRGHTLVLNCTAT-- 255
+ G TCEAT + NY N + I + ++ G+ + L C ++
Sbjct: 2168 DTGRYTCEATNVAGKTEKNY----NVNIWVPPNIGGSDELTQLTVIEGNLISLLCESSGI 2223
Query: 256 TPLNTRVQMTWSYPDEKNKRASVRRRIDQSNSHANIFYS--VLTIDKMQNKDKGLYTCRV 313
P N + W K K + V + S I L I + D LY+C
Sbjct: 2224 PPPN----LIW-----KKKGSPV---LTDSMGRVRILSGGRQLQISIAEKSDAALYSCVA 2271
Query: 314 R--SGPSFKSVNTSVHIYDKAFITVKHRKQQVLETVAGKRSYRLSMKVKAFPSPEVVWLK 371
+G + K N V+I + H + + V +S L +V+ P P V W+K
Sbjct: 2272 SNVAGTAKKEYNLQVYIRPTITNSGSHPTEII---VTRGKSISLECEVQGIPPPTVTWMK 2328
Query: 372 DGLPATE-KSARYLTRGYSLIIKDVTEEDAGNYTILLSIKQSNVFKNLTATLIVNVKPQI 430
DG P + K L G+ L +K++ D G Y + +++ + + + L V+ P I
Sbjct: 2329 DGHPLIKAKGVEILDEGHILQLKNIHVSDTGRY-VCVAVNVAGM-TDKKYDLSVHAPPSI 2386
Query: 431 YEKAVSSFPDPALYPLGSRQILTCTAYGIPQPTIKWF 467
S P+ + LTC A GIP P+I WF
Sbjct: 2387 IGNHRS--PENISVVEKNSVSLTCEASGIPLPSITWF 2421
Score = 66.2 bits (160), Expect = 9e-11
Identities = 119/545 (21%), Positives = 206/545 (37%), Gaps = 109/545 (20%)
Query: 130 DTGRPFVEMYSEIPEIIHMTEGRELVIPCRVTS-----------PNITVTLKKFPLDTL- 177
D G P V + + P + M G + +PC V N+ + + F + ++
Sbjct: 788 DVGSPPV--FIQEPADVSMEIGSNVTLPCYVQGYPEPTIKWRRLDNMPIFSRPFSVSSIS 845
Query: 178 -IPDGKRII---WDSRKGFIISNATYKEIGLLTCEATVNGHLYKTNYLTHRQTNTIIDVQ 233
+ G I W S KG I A + G + E TV T + +
Sbjct: 846 QLRTGALFILNLWASDKGTYICEAE-NQFGKIQSETTVT------------VTGLVAPLI 892
Query: 234 ISTPRPVKLLRGHTLVLNCT--ATTPLNTRVQMTWSYPDEKNKRASVRRRIDQSNSHANI 291
+P ++ G L L CT A P+ R + S +N +VR D S
Sbjct: 893 GISPSVANVIEGQQLTLPCTLLAGNPIPERRWIKNSAMLLQNPYITVRS--DGS------ 944
Query: 292 FYSVLTIDKMQNKDKGLYTCRVRS--GPSFKSVNTSVHIYDKAFITVKHRKQQVLETVAG 349
L I+++Q +D G YTC + G + K+ + VH+ T++H QQ+L T+ G
Sbjct: 945 ----LHIERVQLQDGGEYTCVASNVAGTNNKTTSVVVHVLP----TIQHG-QQILSTIEG 995
Query: 350 KRSYRLSMKVKAFPSPEVVWLKDGLPATEKSARYLTRGY-SLIIKDVTEEDAGNYTILLS 408
L K P P V+W K G + SA++ SL + E++G Y + +
Sbjct: 996 I-PVTLPCKASGNPKPSVIWSKKGELISTSSAKFSAGADGSLYVVSPGGEESGEY--VCT 1052
Query: 409 IKQSNVFKNLTATLIVNVKPQIY--EKAVSSFPDPALYPLGSRQI-LTCTAYGIPQPTIK 465
+ + L V V+P+++ ++ +S + L ++ L C +P P I
Sbjct: 1053 ATNTAGYAKRKVQLTVYVRPRVFGDQRGLSQDKPVEISVLAGEEVTLPCEVKSLPPPIIT 1112
Query: 466 WFWHPCNHNHSEARCDFCSNNEESFILDADSNMGNRIESITQRMAIIEGKNKMASTLVVA 525
W +E+ ++ S + S G K+ T
Sbjct: 1113 WA-------------------KETQLISPFSPRHTFLPS---------GSMKITETR--- 1141
Query: 526 DSRISGIYICIASNKVGTVGRNISFYITDVPNGFHVNLEKMPTE-GEDLKLSCTVNKFLY 584
+ SG+Y+C+A+N G V + + + VP + + + G+ + + C
Sbjct: 1142 -TSDSGMYLCVATNIAGNVTQAVKLNV-HVPPKIQRGPKHLKVQVGQRVDIPCNAQGTPL 1199
Query: 585 RDVTWILLRTVNNRTMHYSISKQKMAITKEHSITL---NLTIMNVSLQDSGTYACRARNV 641
+TW S M + EH ++ L+I + D+G Y C A N+
Sbjct: 1200 PVITW-------------SKGGSTMLVDGEHHVSNPDGTLSIDQATPSDAGIYTCVATNI 1246
Query: 642 YTGEE 646
+E
Sbjct: 1247 AGTDE 1251
Score = 66.2 bits (160), Expect = 9e-11
Identities = 82/354 (23%), Positives = 142/354 (40%), Gaps = 65/354 (18%)
Query: 293 YSVLTIDKMQNKDKGLYTCRVRS--GPSFKSVNTSVHIYDKAFITVKHRKQQVLETVAGK 350
Y L ++ + +D G YTC + G +V+ +VH+ T V ++
Sbjct: 4221 YGELILENVVLEDSGFYTCVANNAAGEDTHTVSLTVHVLP----TFTELPGDV--SLNKG 4274
Query: 351 RSYRLSMKVKAFPSPEVVWLKDG--LPATEKSARYLTRGYS-LIIKDVTEEDAGNYTILL 407
RLS K P P++ W + +PA S G+S L+I+ V++ED+G Y +
Sbjct: 4275 EQLRLSCKATGIPLPKLTWTFNNNIIPAHFDSVN----GHSELVIERVSKEDSGTY--VC 4328
Query: 408 SIKQSNVFKNLTATLIVNVKPQIYEKAVSSFPDPALYPLGSRQILTCTAYGIPQPTIKWF 467
+ + S F + V +P +++ +P + PLG IL C G P PTI+W
Sbjct: 4329 TAENSVGFVKAIGFVYVK-EPPVFK---GDYPSNWIEPLGGNAILNCEVKGDPTPTIQW- 4383
Query: 468 WHPCNHNHSEARCDFCSNNEESFILDADSNMGNRIESITQRMAIIEGKNKMASTLVVADS 527
N + D + +RI + G +A V +
Sbjct: 4384 ------------------NRKG----VDIEISHRIRQL--------GNGSLAIYGTVNED 4413
Query: 528 RISGIYICIASNKVGTVGRNISFYITDVPNGFHVNLEKMPTEGEDLKLSCTVNKFLYRDV 587
+G Y C+A+N+ G V R++S + P +E + G + L+C +
Sbjct: 4414 --AGDYTCVATNEAGVVERSMSLTLQSPPIITLEPVETVINAGGKIILNCQATGEPQPTI 4471
Query: 588 TWILLRTVNNRTMHYSISKQKMAITKEHSITLNLTIMNVSLQDSGTYACRARNV 641
TW +R H ++ + +S L I + +D+ + C ARN+
Sbjct: 4472 TW-------SRQGHSISWDDRVNVLSNNS----LYIADAQKEDTSEFECVARNL 4514
Score = 63.9 bits (154), Expect = 5e-10
Identities = 125/583 (21%), Positives = 207/583 (35%), Gaps = 112/583 (19%)
Query: 92 LTLNTAQANHTGFYSCKYLAVPTSKKKETESAIYIFISDTGRPFVEMYSE-IPEIIHMTE 150
L + Q HTG Y+C LA + K ++ +F+S T + S+ PE + +
Sbjct: 2535 LQITNVQVPHTGRYTC--LASSPAGHKSRSFSLNVFVSPT---IAGVGSDGNPEDVTVIL 2589
Query: 151 GRELVIPCRVTS-PNITVTLKK--FPLDT-----LIPDGKRIIWDSRKGFIISNATYKEI 202
+ C S P T+T K PL++ ++P G+ + I NA
Sbjct: 2590 NSPTSLVCEAYSYPPATITWFKDGTPLESNRNIRILPGGRTLQ--------ILNAQEDNA 2641
Query: 203 GLLTCEATVN-GHLYKTNYLTHRQTNTIIDVQIS---------TPRPVKLLRGHTLVLNC 252
G +C AT G + K H + I I+ +P+ VK+ +TL L C
Sbjct: 2642 GRYSCVATNEAGEMIK-----HYEVKVYIPPIINKGDLWGPGLSPKEVKIKVNNTLTLEC 2696
Query: 253 TATTPLNTRVQMTWSYPDEKNKRASVRRRIDQSNSHANIFYS--VLTIDKMQNKDKGLYT 310
A + ++W Y D + + S+ H NI + L I + Q D G YT
Sbjct: 2697 EAYAIPSA--SLSW-YKDGQPLK---------SDDHVNIAANGHTLQIKEAQISDTGRYT 2744
Query: 311 CRVRSGPSFKSVNTSVHIYDKAFITVKHRKQQVLET--------VAGKRSYRLSMKVKAF 362
C + ++ V+I +L+T V L + A
Sbjct: 2745 CVASNIAGEDELDFDVNIQVPPSFQKLWEIGNMLDTGRNGEAKDVIINNPISLYCETNAA 2804
Query: 363 PSPEVVWLKDGLPATEK-SARYLTRGYSLIIKDVTEEDAGNYTILLSIKQSNVFKNLTAT 421
P P + W KDG P T L G L I EDAG YT + +
Sbjct: 2805 PPPTLTWYKDGHPLTSSDKVLILPGGRVLQIPRAKVEDAGRYTCVAVNEAGEDSLQYDVR 2864
Query: 422 LIVNVKPQIYEKAVSSFPDPALYPLGSRQILTCTAYGIPQPTIKWFWHPCNHNHSEARCD 481
++V P I + A S P+ + ++ C + G P P W
Sbjct: 2865 VLV---PPIIKGANSDLPEEVTVLVNKSALIECLSSGSPAPRNSW--------------- 2906
Query: 482 FCSNNEESFILDADSNMGNRIESITQRMAIIEGKNKMASTLVVADSRISGIYICIASNKV 541
+ +L+ D + I++ N + + G Y+C+A N
Sbjct: 2907 ---QKDGQPLLEDDHH------KFLSNGRILQILNTQITDI--------GRYVCVAENTA 2949
Query: 542 GTVGRNISFYITDVPNGFHVNLEKMPTEGED-LKLSCTVNKFLYRDVTWILLRTVNNRTM 600
G+ + + + P+ E + + + L+C V+ F D++W+
Sbjct: 2950 GSAKKYFNLNVHVPPSVIGPKSENLTVVVNNFISLTCEVSGFPPPDLSWLK--------- 3000
Query: 601 HYSISKQKMAITKEHSIT---LNLTIMNVSLQDSGTYACRARN 640
++Q + + I L I+ + D G Y C A N
Sbjct: 3001 ----NEQPIKLNTNTLIVPGGRTLQIIRAKVSDGGEYTCIAIN 3039
Score = 63.2 bits (152), Expect = 8e-10
Identities = 106/525 (20%), Positives = 195/525 (37%), Gaps = 77/525 (14%)
Query: 43 MQAGQTLHLQCR----GEAAHKWSLPEMVSKESERLSITKSACGRNGKQFCSTLTLNTAQ 98
M+ G + L C E KW + + S S++ + R G F L
Sbjct: 804 MEIGSNVTLPCYVQGYPEPTIKWRRLDNMPIFSRPFSVSSISQLRTGALFILNLW----- 858
Query: 99 ANHTGFYSCKYLAVPTSKKKETESAIYIFISDTGRPFVEMYSEIPEIIHMTEGRELVIPC 158
A+ G Y C+ ++ + +S + ++ P + + P + ++ EG++L +PC
Sbjct: 859 ASDKGTYICE----AENQFGKIQSETTVTVTGLVAPLIGIS---PSVANVIEGQQLTLPC 911
Query: 159 RVTSPNITVTLKKFPLDTLIPDGKRIIWDSRKGFIISNATYKEIGLLTCEAT-VNGHLYK 217
+ + N + ++ I S I ++ G TC A+ V G K
Sbjct: 912 TLLAGNPIPERRWIKNSAMLLQNPYITVRSDGSLHIERVQLQDGGEYTCVASNVAGTNNK 971
Query: 218 TNYLTHRQTNTIIDVQISTPRPVKLLRGHTLVLNCTATTPLNTRVQMTWSYPDEKNKRAS 277
T + TI Q + + + G + L C A+ N + + WS E +S
Sbjct: 972 TTSVVVHVLPTIQHGQ----QILSTIEGIPVTLPCKASG--NPKPSVIWSKKGELISTSS 1025
Query: 278 VRRRIDQSNSHANIFYSVLTIDKMQNKDKGLYTCRV--RSGPSFKSVNTSVHIYDKAFIT 335
+ S L + ++ G Y C +G + + V +V++ + F
Sbjct: 1026 AKFSAGADGS--------LYVVSPGGEESGEYVCTATNTAGYAKRKVQLTVYVRPRVFGD 1077
Query: 336 VKHRKQQ--VLETVAGKRSYRLSMKVKAFPSPEVVWLKDGLPATEKSAR--YLTRGYSLI 391
+ Q V +V L +VK+ P P + W K+ + S R +L G S+
Sbjct: 1078 QRGLSQDKPVEISVLAGEEVTLPCEVKSLPPPIITWAKETQLISPFSPRHTFLPSG-SMK 1136
Query: 392 IKDVTEEDAGNYTILLSIKQSNVFKNLTATLIVNVKPQIYEKAVSSFPDPALYPLGSRQI 451
I + D+G Y + +N+ N+T + +NV + P +G R
Sbjct: 1137 ITETRTSDSGMYLCV----ATNIAGNVTQAVKLNVH---VPPKIQRGPKHLKVQVGQRVD 1189
Query: 452 LTCTAYGIPQPTIKWFWHPCNHNHSEARCDFCSNNEESFILDADSNMGNRIESITQRMAI 511
+ C A G P P I W S + ++D + ++ N ++
Sbjct: 1190 IPCNAQGTPLPVITW-----------------SKGGSTMLVDGEHHVSNPDGTL------ 1226
Query: 512 IEGKNKMASTLVVADSRISGIYICIASNKVGTVGRNISFYITDVP 556
++ A +GIY C+A+N GT I+ ++ + P
Sbjct: 1227 ---------SIDQATPSDAGIYTCVATNIAGTDETEITLHVQEPP 1262
Score = 63.2 bits (152), Expect = 8e-10
Identities = 118/570 (20%), Positives = 209/570 (36%), Gaps = 112/570 (19%)
Query: 92 LTLNTAQANHTGFYSCKYLAVPTSKKKETESAIYIFISDTGRPFVEMYSEIPEIIHMTEG 151
L ++TAQ TG Y+C + KE +++ + G ++ P I +
Sbjct: 3584 LRISTAQVEDTGRYTCLASSPAGDDDKEYLVRVHVPPNIAG-------TDEPRDITVLRN 3636
Query: 152 RELVIPCRVTSPNITVTLKKFPLDTLIPDGKRIIWDSRKGFIISNATYKEIGLLTCEATV 211
R++ + C+ + P+ T + +G+R+ R I+S Y +I T
Sbjct: 3637 RQVTLECKSDAVPP-------PVITWLRNGERLQATPRVR-ILSGGRYLQINNADLGDTA 3688
Query: 212 NGHLYKTNYLTHRQTNTIIDVQIST-----PRPVKLLRGHTLVLNCTATTPLNTRVQMTW 266
N +N I+ V + P+ + +L + VL C A R+ TW
Sbjct: 3689 NYTCVASNIAGKTTREFILTVNVPPNIKGGPQSLVILLNKSTVLECIAEGVPTPRI--TW 3746
Query: 267 SYPDEKNKRASVRRRIDQSNSHANIFYSVLT-----IDKMQNKDKGLYTCRVRS--GPSF 319
K +V + +HA YS+L I D G Y C + G
Sbjct: 3747 ------RKDGAVL-----AGNHAR--YSILENGFLHIQSAHVTDTGRYLCMATNAAGTDR 3793
Query: 320 KSVNTSVHIYDKAFITVKHRKQQVLETVAGKRSYRLSMKVKAFPSPEVVWLKDG----LP 375
+ ++ VH+ I V+ V L+ + P P + W K+G +
Sbjct: 3794 RRIDLQVHVPPS--IAPGPTNMTVIVNV----QTTLACEATGIPKPSINWRKNGHLLNVD 3847
Query: 376 ATEKSARYLTRGYSLIIKDVTEEDAGNYTILLSIKQSNVFKNLTATLIVNVKPQIYEKAV 435
+ S R L+ G SL+I + +D Y ++ + T L V V P I ++
Sbjct: 3848 QNQNSYRLLSSG-SLVIISPSVDDTATYECTVTNGAGD--DKRTVDLTVQVPPSIADE-- 3902
Query: 436 SSFPDPALYPLGSRQILTCTAYGIPQPTIKWFWHPCNHNHSEARCDFCSNNEESFILDAD 495
P L + ++TCTA G+P P+I W + N + D
Sbjct: 3903 ---PTDFLVTKHAPAVITCTASGVPFPSIHW-----------------TKNGIRLLPRGD 3942
Query: 496 SNMGNRIESITQRMAIIEGKNKMASTLVVADSRISGIYICIASNKVGTVGRNISFYITDV 555
G RI S A ++ +G Y C+A N G+ R+++ ++ +
Sbjct: 3943 ---GYRILS------------SGAIEILATQLNHAGRYTCVARNAAGSAHRHVTLHVHEP 3987
Query: 556 PNGFHVNLEKMPTE-----GEDLKLSCTVNKFLYRDVTWILLRTVNNRTMHYSISKQKMA 610
P ++ P+E + L C +TW ++ + S + A
Sbjct: 3988 P-----VIQPQPSELHVILNNPILLPCEATGTPSPFITW------QKEGINVNTSGRNHA 4036
Query: 611 ITKEHSITLNLTIMNVSLQDSGTYACRARN 640
+ + ++ + +D+GTY C A+N
Sbjct: 4037 VLPSGGLQISRAVR----EDAGTYMCVAQN 4062
Score = 62.0 bits (149), Expect = 2e-09
Identities = 70/295 (23%), Positives = 109/295 (36%), Gaps = 45/295 (15%)
Query: 281 RIDQSNSHANIFYS--VLTIDKMQNKDKGLYTCRVRSGPSFKSVNTSVHIYDKAFITVKH 338
R+ ++H I +L I K + D G Y CR + N +++Y I
Sbjct: 3098 RMITESTHVEILADGQMLHIKKAEVSDTGQYVCRAINVAGRDDKNFHLNVYVPPSIEGPE 3157
Query: 339 RKQQVLETVAGKRSYRLSMKVKAFPSPEVVWLKDGLPATEKSA---RYLTRGYSLIIKDV 395
R + ++ET++ L+ P P + WLK+ + R L+ G L I
Sbjct: 3158 R-EVIVETIS--NPVTLTCDATGIPPPTIAWLKNHKRIENSDSLEVRILSGGSKLQIARS 3214
Query: 396 TEEDAGNYTILLSIKQSNVFKNLTATLIVNVKPQIYEKAVSSFPDPALYPLGSRQILTCT 455
D+GNYT + S + K L + V P + A + P LG L C
Sbjct: 3215 QHSDSGNYTCIASNMEGKAQKYY--FLSIQVPPSV---AGAEIPSDVSVLLGENVELVCN 3269
Query: 456 AYGIPQPTIKWFWHPCNHNHSEARCDFCSNNEESFILDADSNMGNRIESITQRMAIIEGK 515
A GIP P I+W + S E + A+ + N ++T
Sbjct: 3270 ANGIPTPLIQWL---------KDGKPIASGETERIRVSANGSTLNIYGALTSD------- 3313
Query: 516 NKMASTLVVADSRISGIYICIASNKVGTVGR--NISFYITDVPNGFHVNLEKMPT 568
+G Y C+A+N G R N++ Y+T G EK+ T
Sbjct: 3314 --------------TGKYTCVATNPAGEEDRIFNLNVYVTPTIRGNKDEAEKLMT 3354
Score = 61.6 bits (148), Expect = 2e-09
Identities = 127/576 (22%), Positives = 201/576 (34%), Gaps = 104/576 (18%)
Query: 84 NGKQFCSTLTLNTAQANHTGFYSCKYLAVPTSKKKETESAIYIFISDTGRPFVEMYSEIP 143
NGK L L A G YSCK + + + +K F D P + + P
Sbjct: 1412 NGK----ILKLFRATPEDAGRYSCKAINIAGTSQK-------YFNIDVLVPPTIIGTNFP 1460
Query: 144 EIIHMTEGRELVIPCRVTSPNITVTLKKFPLDTLIPDGKRI--------IWDSRKGFIIS 195
+ + R++ + C+V FP DGK + + D + +
Sbjct: 1461 NEVSVVLNRDVALECQVKGT-------PFPDIHWFKDGKPLFLGDPNVELLDRGQVLHLK 1513
Query: 196 NATYKEIGLLTCEAT-VNGHLYKTNYLTHRQTNTIIDVQISTPRPVKLLRGHTLVLNC-T 253
NA + G C + G K LT +I ++T + +L + L C T
Sbjct: 1514 NARRNDKGRYQCTVSNAAGKQAKDIKLTIYIPPSIKGGNVTTD--ISVLINSLIKLECET 1571
Query: 254 ATTPLNTRVQMTWSYPDEKNKRASVRRRIDQSNSHANIFYSVLTIDKMQNKDKGLYTCRV 313
P+ +TW + +S ID+ L I + Q D YTC V
Sbjct: 1572 RGLPMPA---ITWYKDGQPIMSSSQALYIDKGQ--------YLHIPRAQVSDSATYTCHV 1620
Query: 314 RS--GPSFKSVNTSVHIYD--KAFITVKHRKQQVLETVAGKRSYRLSMKVKAFPSPEVVW 369
+ G + KS + V++ + + KQ V+ S L K PSP + W
Sbjct: 1621 ANVAGTAEKSFHVDVYVPPMIEGNLATPLNKQVVIA-----HSLTLECKAAGNPSPILTW 1675
Query: 370 LKDGLPA-TEKSARYLTRGYSLIIKDVTEEDAGNYTILLSIKQSNVFKNLTATLIVNVKP 428
LKDG+P + R G L I E D G Y + + K + + V V P
Sbjct: 1676 LKDGVPVKANDNIRIEAGGKKLEIMSAQEIDRGQYICVATSVAGE--KEIKYEVDVLVPP 1733
Query: 429 QIYEKAVSSFPDPALYPLGSRQILTCTAYGIPQPTIKWFWHPCNHNHSEARCDFCSNNEE 488
I +S+ + + + L C G P PTI W
Sbjct: 1734 AIEGGDETSY---FIVMVNNLLELDCHVTGSPPPTIMWL--------------------- 1769
Query: 489 SFILDADSNMGNRIESITQRMAIIEGKNKMASTLVVADSRIS--GIYICIASNKVGTVGR 546
G I+ ++ G+ LV+A +++S G+Y C+A+N G +
Sbjct: 1770 --------KDGQLIDERDGFKILLNGRK-----LVIAQAQVSNTGLYRCMAANTAGDHKK 1816
Query: 547 NISFYITDVPNGFHVNL-EKMPTEGEDLKLSCTVNKFLYRDVTWIL-LRTVNNRTMHYSI 604
+ P L E++ + + + L C N +TW+ + VN + I
Sbjct: 1817 EFEVTVHVPPTIKSSGLSERVVVKYKPVALQCIANGIPNPSITWLKDDQPVNTAQGNLKI 1876
Query: 605 SKQKMAITKEHSITLNLTIMNVSLQDSGTYACRARN 640
L I L+D+G Y C A N
Sbjct: 1877 QSSGRV----------LQIAKTLLEDAGRYTCVATN 1902
Score = 61.6 bits (148), Expect = 2e-09
Identities = 87/360 (24%), Positives = 137/360 (38%), Gaps = 60/360 (16%)
Query: 296 LTIDKMQNKDKGLYTCRV--RSGPSFKSVNTSVHIYDKAFITVKHRKQQVLETVAGKRSY 353
L I + + D G YTC ++G S K + +V++ ++K + L V +
Sbjct: 3020 LQIIRAKVSDGGEYTCIAINQAGESKKKFSLTVYVPP----SIKDHDSESLSVVNVREGT 3075
Query: 354 RLSMKVK--AFPSPEVVWLKDGLPATEKS-ARYLTRGYSLIIKDVTEEDAGNYTILLSIK 410
+S++ + A P P + W K+G TE + L G L IK D G Y
Sbjct: 3076 SVSLECESNAVPPPVITWYKNGRMITESTHVEILADGQMLHIKKAEVSDTGQYVCRAINV 3135
Query: 411 QSNVFKNLTATLIV--NVKPQIYEKAVSSFPDPALYPLGSRQILTCTAYGIPQPTIKWFW 468
KN + V +++ E V + +P LTC A GIP PTI W
Sbjct: 3136 AGRDDKNFHLNVYVPPSIEGPEREVIVETISNPVT--------LTCDATGIPPPTIAWL- 3186
Query: 469 HPCNHNHSEARCDFCSNNEESFILDADSNMGNRIESITQRMAIIEGKNKMASTLVVADSR 528
NH E N +S + I+ G +K+ + +
Sbjct: 3187 --KNHKRIE--------NSDSL-----------------EVRILSGGSKL--QIARSQHS 3217
Query: 529 ISGIYICIASNKVGTVGRNISFYITDVPN--GFHVNLEKMPTEGEDLKLSCTVNKFLYRD 586
SG Y CIASN G + I P+ G + + GE+++L C N
Sbjct: 3218 DSGNYTCIASNMEGKAQKYYFLSIQVPPSVAGAEIPSDVSVLLGENVELVCNAN-----G 3272
Query: 587 VTWILLRTVNNRTMHYSISKQKMAITKEHSITLNLTIMNVSLQDSGTYACRARNVYTGEE 646
+ L++ + + S +++ ++ S L I D+G Y C A N GEE
Sbjct: 3273 IPTPLIQWLKDGKPIASGETERIRVSANGS---TLNIYGALTSDTGKYTCVATNP-AGEE 3328
Score = 60.8 bits (146), Expect = 4e-09
Identities = 115/547 (21%), Positives = 189/547 (34%), Gaps = 84/547 (15%)
Query: 103 GFYSCKYLAVPTSKKKETESAIYIFISDTGRPFVEMYSEIPEIIHMTEGRELVIPCRVTS 162
GFY C ++ + + +T D P ++P + +T G V+ C + S
Sbjct: 495 GFYECIAVSSAGTGRAQT-------FFDVSEP--PPVIQVPNNVTVTPGERAVLTCLIIS 545
Query: 163 P-NITVTLKKFPLDTLIPDGKRIIWDSRKGFIISNATYKEIGLLTCEATVNGHLYKTNYL 221
+ +T ++ D + + RI + + + + + G C + G +
Sbjct: 546 AVDYNLTWQRNDRDVRLAEPARIRTLANLSLELKSVKFNDAGEYHCMVSSEGGSSAASVF 605
Query: 222 THRQTNTIIDVQISTPRPVKLLRGHTLVLNCTATTPLNTRVQMTWSYPDEKNKRASVRRR 281
Q + V P+ G + + C+AT YP K
Sbjct: 606 LTVQEPPKVTVM---PKNQSFTGGSEVSIMCSAT-----------GYPKPKIAWTVNDMF 651
Query: 282 IDQSNSHANIFYSVLTIDKMQNKDKGLYTCRVRSGPSFKSVNTSVHIYDKAFITVKHRKQ 341
I S+ + L I KD G+Y C + N+++ + + V Q
Sbjct: 652 IVGSHRYRMTSDGTLFIKNAAPKDAGIYGCLASNSAGTDKQNSTLRYIEAPKLMVV---Q 708
Query: 342 QVLETVAGKRSYRLSMKVKAFPSPEVVWLKDGLPATEKSARYLTRGYSLI-IKDVTEEDA 400
L G + + K P P+V W K L + + L+ I++ + DA
Sbjct: 709 SELLVALGDITV-MECKTSGIPPPQVKWFKGDLELRPSTFLIIDPLLGLLKIQETQDLDA 767
Query: 401 GNYTILLSIKQSNVFKNLTATLIVNVKPQIYEKAVSSFPDPALYPLGSRQILTCTAYGIP 460
G+YT + + +T L V P ++ P +GS L C G P
Sbjct: 768 GDYTCVAINEAGRATGKIT--LDVGSPPVFIQE-----PADVSMEIGSNVTLPCYVQGYP 820
Query: 461 QPTIKWFWHPCNHNHSEARCDFCSNNEESFILDADSNMGNRIESITQRMAIIEGKNKMAS 520
+PTIKW R D F + + S + R + N AS
Sbjct: 821 EPTIKW-----------RRLDNMPIFSRPFSVSSISQL---------RTGALFILNLWAS 860
Query: 521 TLVVADSRISGIYICIASNKVGTVGRNISFYITDVPN---GFHVNLEKMPTEGEDLKLSC 577
G YIC A N+ G + + +T + G ++ + EG+ L L C
Sbjct: 861 D--------KGTYICEAENQFGKIQSETTVTVTGLVAPLIGISPSVANV-IEGQQLTLPC 911
Query: 578 TV---NKFLYRDVTWILLRTVNNRTMHYSISKQKMAITKEHSITLNLTIMNVSLQDSGTY 634
T+ N R R + N M + + + + S L I V LQD G Y
Sbjct: 912 TLLAGNPIPER-------RWIKNSAM--LLQNPYITVRSDGS----LHIERVQLQDGGEY 958
Query: 635 ACRARNV 641
C A NV
Sbjct: 959 TCVASNV 965
Score = 60.1 bits (144), Expect = 7e-09
Identities = 126/593 (21%), Positives = 210/593 (35%), Gaps = 142/593 (23%)
Query: 91 TLTLNTAQANHTGFYSCKYLAVPTSKKKETESAIYIFISDTGRPFVEMYSEIPEIIHMTE 150
+L + Q G Y+C V + K T +++ P ++ +I I E
Sbjct: 944 SLHIERVQLQDGGEYTCVASNVAGTNNKTTSVVVHVL------PTIQHGQQILSTI---E 994
Query: 151 GRELVIPCRVT-SPNITVTLKKFPLDTLIPDGKRIIWDSRKGFIISNATYK--------- 200
G + +PC+ + +P +V IW S+KG +IS ++ K
Sbjct: 995 GIPVTLPCKASGNPKPSV-----------------IW-SKKGELISTSSAKFSAGADGSL 1036
Query: 201 --------EIGLLTCEATVNGHLYK-----TNYLTHRQTNTIIDVQISTPRPVKLLRGHT 247
E G C AT K T Y+ R + P + +L G
Sbjct: 1037 YVVSPGGEESGEYVCTATNTAGYAKRKVQLTVYVRPRVFGDQRGLSQDKPVEISVLAGEE 1096
Query: 248 LVLNCTATT---PLNTRVQMTWSYPDEKNKRASVRRRIDQSNSHANIFYSVLTIDKMQNK 304
+ L C + P+ +TW+ + S R S S + I + +
Sbjct: 1097 VTLPCEVKSLPPPI-----ITWAKETQLISPFSPRHTFLPSGS--------MKITETRTS 1143
Query: 305 DKGLYTCRVRS--GPSFKSVNTSVHIYDKAFITVKHRKQQVLETVAGKRSYRLSMKVKAF 362
D G+Y C + G ++V +VH+ K KH K QV + V + +
Sbjct: 1144 DSGMYLCVATNIAGNVTQAVKLNVHVPPKIQRGPKHLKVQVGQRVD------IPCNAQGT 1197
Query: 363 PSPEVVWLKDGLPATEKSARYLTR-GYSLIIKDVTEEDAGNYTILLSIKQSNVFKNLTAT 421
P P + W K G +++ +L I T DAG YT + + N+ T
Sbjct: 1198 PLPVITWSKGGSTMLVDGEHHVSNPDGTLSIDQATPSDAGIYTCVAT--------NIAGT 1249
Query: 422 LIVNVKPQIYEKAVSSFPDPALYPLGSRQILT------CTAYGIPQPTIKWFWHPCNHNH 475
+ + E +P ++ C A G P+PTIKW HN
Sbjct: 1250 DETEITLHVQEPPTVEDLEPPYNTTFQERVANQRIEFPCPAKGTPKPTIKWL-----HN- 1303
Query: 476 SEARCDFCSNNEESFILDADSNMGNRIESITQRMAIIEGKNKMASTLVVAD--SRISGIY 533
G + ++I+E + LV+A +G Y
Sbjct: 1304 -----------------------GRELTGREPGISILED----GTLLVIASVTPYDNGEY 1336
Query: 534 ICIASNKVGTVGRNISFYITDVPNGFHVNLEKMPTEGEDLKLSCTVNKFLYRDVTWILLR 593
IC+A N+ GT R + + P V +K + L+ N F +
Sbjct: 1337 ICVAVNEAGTTERKYNLKVHVPP----VIKDKEQVTNVSVLLNQLTNLFCEVE------G 1386
Query: 594 TVNNRTMHYSISKQKMAITKEHSI-TLN----LTIMNVSLQDSGTYACRARNV 641
T + M Y K + +T+ +I T+N L + + +D+G Y+C+A N+
Sbjct: 1387 TPSPIIMWY---KDNVQVTESSTIQTVNNGKILKLFRATPEDAGRYSCKAINI 1436
Score = 59.7 bits (143), Expect = 9e-09
Identities = 104/498 (20%), Positives = 195/498 (39%), Gaps = 76/498 (15%)
Query: 66 MVSKESERLSITKSACGRNGKQFCSTLTLNTAQANHTGFYSCKYLAVPTSKKKETESAIY 125
+ S E+ER+ ++ + STL + A + TG Y+C +A + +++ +
Sbjct: 3287 IASGETERIRVSANG---------STLNIYGALTSDTGKYTC--VATNPAGEEDRIFNLN 3335
Query: 126 IFISDTGRPFVEMYSEIPEIIHMTEGRELVIPCRVT-SPNITVTLKKFPLDTLIPDGKRI 184
++++ T R + ++ ++ + + I CR T +P + K L + R+
Sbjct: 3336 VYVTPTIRGNKDEAEKLMTLVDTS----INIECRATGTPPPQINWLKNGLPLPLSSHIRL 3391
Query: 185 IWDSRKGFIISNATYKEIGLLTCEATVNGHLYKTNYLTHRQTNTIIDVQISTPRPVKLLR 244
+ + I+ A ++ + TC A+ + +Y +D + T + +L+
Sbjct: 3392 LAAGQVIRIV-RAQVSDVAVYTCVASNRAGVDNKHYNLQVFAPPNMDNSMGTEE-ITVLK 3449
Query: 245 GHTLVLNC-TATTPLNTRVQMTWSYPDEKNKRASVRRRIDQSNSHANIFYSVLTIDKMQN 303
G + + C T TP + + P + +V ++H VL + K +
Sbjct: 3450 GSSTSMACITDGTPAPSMAWLRDGQPLGLDAHLTV-------STHG----MVLQLLKAET 3498
Query: 304 KDKGLYTCRVRSGPSFKSVNTSVHIYDKAFITVKHRKQQVLETVAGKRSYRLSMKVKAFP 363
+D G YTC + S + + + + I +++ +V L+ P
Sbjct: 3499 EDSGKYTCIASNEAGEVSKHFILKVLEPPHINGSEEHEEI--SVIVNNPLELTCIASGIP 3556
Query: 364 SPEVVWLKDG--LPATEKSARYLTRGYSLIIKDVTEEDAGNYTILLSIKQSNVFKNLTAT 421
+P++ W+KDG LP T++ + L G L I ED G YT L S + K
Sbjct: 3557 APKMTWMKDGRPLPQTDQ-VQTLGGGEVLRISTAQVEDTGRYTCLASSPAGDDDKEYLVR 3615
Query: 422 LIVNVKPQIYEKAVSSFPDPA-LYPLGSRQI-LTCTAYGIPQPTIKWFWHPCNHNHSEAR 479
V+V P I + +P + L +RQ+ L C + +P P I W
Sbjct: 3616 --VHVPPNI-----AGTDEPRDITVLRNRQVTLECKSDAVPPPVITWL------------ 3656
Query: 480 CDFCSNNEESFILDADSNMGNRIESITQRMAIIEGKNKMASTLVVADSRISGIYICIASN 539
G R+++ T R+ I+ G + + AD + Y C+ASN
Sbjct: 3657 -----------------RNGERLQA-TPRVRILSGGRYL--QINNADLGDTANYTCVASN 3696
Query: 540 KVGTVGRNISFYITDVPN 557
G R + PN
Sbjct: 3697 IAGKTTREFILTVNVPPN 3714
Score = 57.4 bits (137), Expect = 4e-08
Identities = 78/354 (22%), Positives = 122/354 (34%), Gaps = 57/354 (16%)
Query: 295 VLTIDKMQNKDKGLYTCRVRSGPSFKSVNTSVHIYDKAFITVKHRKQQVLETVAGKRSYR 354
VL I + + +D G YTC + S+ V + I + TV +S
Sbjct: 2832 VLQIPRAKVEDAGRYTCVAVNEAGEDSLQYDVRVLVPPIIKGANSDLPEEVTVLVNKSAL 2891
Query: 355 LSMKVKAFPSPEVVWLKDGLPATEKS-ARYLTRGYSLIIKDVTEEDAGNYTILLSIKQSN 413
+ P+P W KDG P E ++L+ G L I + D G Y + +
Sbjct: 2892 IECLSSGSPAPRNSWQKDGQPLLEDDHHKFLSNGRILQILNTQITDIGRYVCVAENTAGS 2951
Query: 414 VFKNLTATLIVNVKPQIYEKAVSSFPDPALYPLGSRQILTCTAYGIPQPTIKWFWHPCNH 473
K L V+V P + + + + + LTC G P P + W
Sbjct: 2952 AKKYF--NLNVHVPPSV----IGPKSENLTVVVNNFISLTCEVSGFPPPDLSWL------ 2999
Query: 474 NHSEARCDFCSNNEESFILDADSNMGNRIESITQRMAIIEGKNKMASTLVVADSRIS--G 531
NE+ L+ ++ I+ G TL + +++S G
Sbjct: 3000 -----------KNEQPIKLNTNT-------------LIVPG----GRTLQIIRAKVSDGG 3031
Query: 532 IYICIASNKVGTVGRNISFYITDVPNGFHVNLEKMPT----EGEDLKLSCTVNKFLYRDV 587
Y CIA N+ G + S + P+ + E + EG + L C N +
Sbjct: 3032 EYTCIAINQAGESKKKFSLTVYVPPSIKDHDSESLSVVNVREGTSVSLECESNAVPPPVI 3091
Query: 588 TWILLRTVNNRTMHYSISKQKMAITKEHSITLNLTIMNVSLQDSGTYACRARNV 641
TW + + H I L I + D+G Y CRA NV
Sbjct: 3092 TWYKNGRMITESTHVEILADGQM----------LHIKKAEVSDTGQYVCRAINV 3135
Score = 50.8 bits (120), Expect = 4e-06
Identities = 115/572 (20%), Positives = 203/572 (35%), Gaps = 102/572 (17%)
Query: 91 TLTLNTAQANHTGFYSCKYLAVPTSKKKETESAIYIFISDTGRPFVEMY-SEIPEIIHMT 149
TL + A+ + G Y+C + KK+ +Y+ P ++ + SE ++++
Sbjct: 3019 TLQIIRAKVSDGGEYTCIAINQAGESKKKFSLTVYV------PPSIKDHDSESLSVVNVR 3072
Query: 150 EGRELVIPCRVTS--PNITVTLKKFPLDT------LIPDGKRIIWDSRKGFIISNATYKE 201
EG + + C + P + K + T ++ DG+ + I A +
Sbjct: 3073 EGTSVSLECESNAVPPPVITWYKNGRMITESTHVEILADGQMLH--------IKKAEVSD 3124
Query: 202 IGLLTCEA-TVNGHLYKTNYLTHRQTNTIIDVQISTPRPVKLLR--GHTLVLNCTATTPL 258
G C A V G K +L N + I P ++ + + L C AT
Sbjct: 3125 TGQYVCRAINVAGRDDKNFHL-----NVYVPPSIEGPEREVIVETISNPVTLTCDAT--- 3176
Query: 259 NTRVQMTWSYPDEKNKRASVRRRIDQSNS-HANIFY--SVLTIDKMQNKDKGLYTCRVRS 315
P +RI+ S+S I S L I + Q+ D G YTC +
Sbjct: 3177 --------GIPPPTIAWLKNHKRIENSDSLEVRILSGGSKLQIARSQHSDSGNYTCIASN 3228
Query: 316 --GPSFKSVNTSVHIYDKAFITVKHRKQQVLETVAGKRSYRLSMKVKAFPSPEVVWLKDG 373
G + K S+ + +V + +V + L P+P + WLKDG
Sbjct: 3229 MEGKAQKYYFLSIQVPP----SVAGAEIPSDVSVLLGENVELVCNANGIPTPLIQWLKDG 3284
Query: 374 LPATE---KSARYLTRGYSLIIKDVTEEDAGNYTILLSIKQSNVFKNLTATLIVNVKPQI 430
P + R G +L I D G YT + + ++ L V V P I
Sbjct: 3285 KPIASGETERIRVSANGSTLNIYGALTSDTGKYTCVATNPAGE--EDRIFNLNVYVTPTI 3342
Query: 431 YEKAVSSFPDPALYPLGSRQILTCTAYGIPQPTIKWFWHPCNHNHSEARCDFCSNNEESF 490
+ + + + + + C A G P P I W +
Sbjct: 3343 --RGNKDEAEKLMTLVDTSINIECRATGTPPPQINWL-------------------KNGL 3381
Query: 491 ILDADSNMGNRIESITQRMAIIEGKNKMASTLVVADSRISGIYICIASNKVGTVGRNISF 550
L S++ R+ + Q + I+ + V+D +Y C+ASN+ G ++ +
Sbjct: 3382 PLPLSSHI--RLLAAGQVIRIVRAQ--------VSDV---AVYTCVASNRAGVDNKHYNL 3428
Query: 551 YITDVPN-GFHVNLEKMPT-EGEDLKLSCTVNKFLYRDVTWILLRTVNNRTMHYSISKQK 608
+ PN + E++ +G ++C + + W+ H ++S
Sbjct: 3429 QVFAPPNMDNSMGTEEITVLKGSSTSMACITDGTPAPSMAWLRDGQPLGLDAHLTVSTHG 3488
Query: 609 MAITKEHSITLNLTIMNVSLQDSGTYACRARN 640
M L ++ +DSG Y C A N
Sbjct: 3489 MV----------LQLLKAETEDSGKYTCIASN 3510
Score = 47.4 bits (111), Expect = 5e-05
Identities = 79/371 (21%), Positives = 128/371 (34%), Gaps = 62/371 (16%)
Query: 280 RRIDQSNSHANIFYSVLTIDKMQNKDKGLYTCRVRSGPSFKSVNTSVHIYDKAFITVKHR 339
R + + + + + + I Q G YTC R+ + ++H+++ I +
Sbjct: 3936 RLLPRGDGYRILSSGAIEILATQLNHAGRYTCVARNAAGSAHRHVTLHVHEPPVIQPQPS 3995
Query: 340 KQQVLETVAGKRSYRLSMKVKAFPSPEVVWLKDGLPATEKSARY--LTRGYSLIIKDVTE 397
+ V+ L + PSP + W K+G+ + L G L I
Sbjct: 3996 ELHVILN----NPILLPCEATGTPSPFITWQKEGINVNTSGRNHAVLPSG-GLQISRAVR 4050
Query: 398 EDAGNYTILLSIKQSNVFKNLTATLIVNVKPQIYEKAVSSFPDPALYPLGSRQILT--CT 455
EDAG Y V +N T + +K + V S P Y + + +T C
Sbjct: 4051 EDAGTYMC--------VAQNPAGTALGKIKLNVQVPPVIS-PHLKEYVIAVDKPITLSCE 4101
Query: 456 AYGIPQPTIKWFWHPCNHNHSEARCDFCSNNEESFILDADSNMGNRIESITQRMAIIEGK 515
A G+P P I W H + R +ESI QR+ + G
Sbjct: 4102 ADGLPPPDITW--------HKDGRAI--------------------VESIRQRV-LSSGS 4132
Query: 516 NKMASTLVVADSRISGIYICIASNKVGTVGRNISFYITDVPNGFHVNLEKMPTEGEDLKL 575
++A +G Y C+A+N G+ + + P E L
Sbjct: 4133 LQIA----FVQPGDAGHYTCMAANVAGSSSTSTKLTVHVPPRIRSTEGHYTVNENSQAIL 4188
Query: 576 SCTVNKFLYRDVTWILLRTVNNRTMHYSISKQKMAITKEHSITLNLTIMNVSLQDSGTYA 635
C + + W +N + + K E L + NV L+DSG Y
Sbjct: 4189 PCVADGIPTPAINW----KKDNVLLANLLGKYTAEPYGE------LILENVVLEDSGFYT 4238
Query: 636 CRARNVYTGEE 646
C A N GE+
Sbjct: 4239 CVANNA-AGED 4248
Score = 45.4 bits (106), Expect = 2e-04
Identities = 120/580 (20%), Positives = 207/580 (35%), Gaps = 101/580 (17%)
Query: 91 TLTLNTAQANHTGFYSCKYLAVPTSKKKETESAIYIFISDTGRPFVEMYSEIPEIIHMTE 150
+L L + + N G Y C + +S+ + +++++ + + + V +P+ T
Sbjct: 575 SLELKSVKFNDAGEYHC----MVSSEGGSSAASVFLTVQEPPKVTV-----MPKNQSFTG 625
Query: 151 GRELVIPCRVTS---PNITVTLKKFPLDTLIPDGKRIIWDSRKGFIISNATYKEIGLLTC 207
G E+ I C T P I T+ D I R S I NA K+ G+ C
Sbjct: 626 GSEVSIMCSATGYPKPKIAWTVN----DMFIVGSHRYRMTSDGTLFIKNAAPKDAGIYGC 681
Query: 208 EATVNGHLYKTNY-LTHRQTNTIIDVQISTPRPVKLLRGHTLVLNC-TATTPLNTRVQMT 265
A+ + K N L + + ++ VQ + + G V+ C T+ P Q+
Sbjct: 682 LASNSAGTDKQNSTLRYIEAPKLMVVQSE----LLVALGDITVMECKTSGIP---PPQVK 734
Query: 266 WSYPDEKNKRASVRRRIDQSNSHANIFYSVLTIDKMQNKDKGLYTCRVRSGPSFKSVNTS 325
W + + R S ID +L I + Q+ D G YTC ++N +
Sbjct: 735 W-FKGDLELRPSTFLIIDP-------LLGLLKIQETQDLDAGDYTC--------VAINEA 778
Query: 326 VHIYDKAFITVKHRKQQVLE----TVAGKRSYRLSMKVKAFPSPEVVWLK-DGLPATEK- 379
K + V + E ++ + L V+ +P P + W + D +P +
Sbjct: 779 GRATGKITLDVGSPPVFIQEPADVSMEIGSNVTLPCYVQGYPEPTIKWRRLDNMPIFSRP 838
Query: 380 ---SARYLTRGYSLIIKDVTEEDAGNYTILLSIKQSNVFKNLTATLIVNVKPQIYEKAVS 436
S+ R +L I ++ D G Y + + T T+ V P I
Sbjct: 839 FSVSSISQLRTGALFILNLWASDKGTYICEAENQFGKIQSETTVTVTGLVAPLI-----G 893
Query: 437 SFPDPALYPLGSRQILTCTAY-GIPQPTIKWFWHPCNHNHSEARCDFCSNNEESFILDAD 495
P A G + L CT G P P +W N + +
Sbjct: 894 ISPSVANVIEGQQLTLPCTLLAGNPIPERRWI-----------------KNSAMLLQNPY 936
Query: 496 SNMGNRIESITQRMAIIEGKNKMASTLVVADSRISGIYICIASNKVGTVGRNISFYITDV 555
+ + +R+ + +G G Y C+ASN GT + S + +
Sbjct: 937 ITVRSDGSLHIERVQLQDG----------------GEYTCVASNVAGTNNKTTSVVVHVL 980
Query: 556 PNGFHVNLEKMPTEGEDLKLSCTVNKFLYRDVTWILLRTVNNRTMHYSISKQKMAITKEH 615
P H EG + L C + V W + + S S K + +
Sbjct: 981 PTIQHGQQILSTIEGIPVTLPCKASGNPKPSVIW------SKKGELISTSSAKFSAGADG 1034
Query: 616 SITLNLTIMNVSLQDSGTYACRARNVYTGEEILQKKEITI 655
S L +++ ++SG Y C A N T +K ++T+
Sbjct: 1035 S----LYVVSPGGEESGEYVCTATN--TAGYAKRKVQLTV 1068
>gi|7657359 contactin 5 isoform long [Homo sapiens]
Length = 1100
Score = 83.2 bits (204), Expect = 7e-16
Identities = 120/580 (20%), Positives = 218/580 (37%), Gaps = 88/580 (15%)
Query: 95 NTAQANHTGFYSCKYLAVPTSKKKETESAIYIFISD-TGRPFVEMYSEIPEIIHMTEGRE 153
N ++A +G Y C S + + ++ + +GR + + EG+
Sbjct: 161 NPSEAKDSGHYQCLATNTVGSILSREATLQFAYLGNFSGRT--------RSAVSVREGQG 212
Query: 154 LVIPCRVT--SPNITVT--LKKFPLDTLIPDGKRIIWDSRKGFIISNATYKEIGLLTC-- 207
+V+ C SP I + +FP + D +R I IS ++G C
Sbjct: 213 VVLMCSPPPHSPEIIYSWVFNEFP-SFVAEDSRRFISQETGNLYISKVQTSDVGSYICLV 271
Query: 208 -EATVNGH-LYKTNYLTHRQTNTIID----VQISTPRPVKLLRGHTLVLNCTAT-TPLNT 260
N L LT R + + +++ P V +G T+ + C A P+ T
Sbjct: 272 KNTVTNARVLSPPTPLTLRNDGVMGEYEPKIEVHFPFTVTAAKGTTVKMECFALGNPVPT 331
Query: 261 RVQMTWSYPDEKNKRASVRRRIDQSNSHANIFYSVLTIDKMQNKDKGLYTCRVRSGPSFK 320
+TW + N + R+ +S + VL I +Q D G+Y CR +
Sbjct: 332 ---ITWM---KVNGYIPSKARLRKSQA-------VLEIPNVQLDDAGIYECRAENSRGKN 378
Query: 321 SVNTSVHIYDKAFITVKHRKQQVLETVAGKRS-YRLSMKVKAFPSPEVVWLKDGLPATEK 379
S + +Y T H +++ +T S R K P P WLK+G+P + +
Sbjct: 379 SFRGQLQVY-----TYPHWVEKLNDTQLDSGSPLRWECKATGKPRPTYRWLKNGVPLSPQ 433
Query: 380 SARYLTRGYSLIIKDVTEEDAGNYTILLSIKQSNVFKNLTATLIVNVKPQIYEKAVSSFP 439
S + G L+I +V + DAG Y L K ++ + ++ + A++
Sbjct: 434 SRVEMVNGV-LMIHNVNQSDAGMYQCLAENKYGAIYASAELKILASAP----TFALNQLK 488
Query: 440 DPALYPLGSRQILTCTAYGIPQPTIKWFWHPCNHNHSEARCDFCSNNEESFILDADSNMG 499
+ ++ C G P+PTI W G
Sbjct: 489 KTIIVTKDQEVVIECKPQGSPKPTISW------------------------------KKG 518
Query: 500 NRIESITQRMAII-EGKNKMASTLVVADSRISGIYICIASNKVGTVGRNISFYITDVPNG 558
+R +R+AI+ +G ++ + A G Y+C N G+ S + + P
Sbjct: 519 DRAVRENKRIAILPDGSLRILN----ASKSDEGKYVCRGENVFGSAEIIASLSVKE-PTR 573
Query: 559 FHVNLEKMP-TEGEDLKLSCTVNKFLYRDVTWILLRTVNNRTMHYSISKQKMAITKEHSI 617
+ ++ T GE + L+C DVT+ T+ + + + + +
Sbjct: 574 IELTPKRTELTVGESIVLNCKAIHDASLDVTFYW--TLKGQPIDFEEEGGHFESIRAQAS 631
Query: 618 TLNLTIMNVSLQDSGTYACRARNVYTGEEILQKKEITIRG 657
+ +L I N+ L +G Y CR + T + + + E+ +RG
Sbjct: 632 SADLMIRNILLMHAGRYGCRVQT--TADSVSDEAELLVRG 669
Score = 38.9 bits (89), Expect = 0.016
Identities = 54/237 (22%), Positives = 95/237 (40%), Gaps = 38/237 (16%)
Query: 92 LTLNTAQANHTGFYSC----KYLAVPTSKKKETESAIYIFISDTGRPFVEMYSEIPEIIH 147
L ++ + G Y C KY A+ S + + ++ F +++ + I
Sbjct: 443 LMIHNVNQSDAGMYQCLAENKYGAIYASAELKILASAPTFA----------LNQLKKTII 492
Query: 148 MTEGRELVIPCRVT-SPNITVTLKKFPLDTLIPDGKRIIWDSRKGFIISNATYKEIGLLT 206
+T+ +E+VI C+ SP T++ KK D + + KRI I NA+ + G
Sbjct: 493 VTKDQEVVIECKPQGSPKPTISWKKG--DRAVRENKRIAILPDGSLRILNASKSDEGKYV 550
Query: 207 CEA-TVNGHLYKTNYLTHRQTNTIIDVQISTPRPVKLLRGHTLVLNCTATTPLNTRVQMT 265
C V G L+ ++ I TP+ +L G ++VLNC A + V
Sbjct: 551 CRGENVFGSAEIIASLSVKEPTRIE----LTPKRTELTVGESIVLNCKAIHDASLDVTFY 606
Query: 266 WS-------YPDEKNKRASVRRRIDQSNSHANIFYSVLTIDKMQNKDKGLYTCRVRS 315
W+ + +E S+R + ++ L I + G Y CRV++
Sbjct: 607 WTLKGQPIDFEEEGGHFESIRAQASSAD---------LMIRNILLMHAGRYGCRVQT 654
Score = 37.0 bits (84), Expect = 0.061
Identities = 49/226 (21%), Positives = 86/226 (38%), Gaps = 44/226 (19%)
Query: 439 PDPALYPLGSRQ---ILTCTAYGIPQPTIKWFWHPCNHNHSEARCDFCSNNEESFILDAD 495
PD ++P S + L C G P P+ +W N L++D
Sbjct: 105 PDDIIFPTDSDEKKVALNCEVRGNPVPSYRWL-----------------RNGTEIDLESD 147
Query: 496 SNMGNRIESITQRMAIIEGKNKMASTLVVADSRISGIYICIASNKVGTV-GRNISFYITD 554
R ++I+G +++ ++++ SG Y C+A+N VG++ R +
Sbjct: 148 -----------YRYSLIDGTFIISNP---SEAKDSGHYQCLATNTVGSILSREATLQFAY 193
Query: 555 VPN-GFHVNLEKMPTEGEDLKLSCTVNKFLYRDVTWILLRTVNNRTMHYSISKQKMAITK 613
+ N EG+ + L C+ I+ V N + + I++
Sbjct: 194 LGNFSGRTRSAVSVREGQGVVLMCSPPPHSPE----IIYSWVFNEFPSFVAEDSRRFISQ 249
Query: 614 EHSITLNLTIMNVSLQDSGTYACRARNVYTGEEILQ-KKEITIRGE 658
E T NL I V D G+Y C +N T +L +T+R +
Sbjct: 250 E---TGNLYISKVQTSDVGSYICLVKNTVTNARVLSPPTPLTLRND 292
>gi|28373129 contactin 5 isoform short [Homo sapiens]
Length = 1026
Score = 83.2 bits (204), Expect = 7e-16
Identities = 120/580 (20%), Positives = 218/580 (37%), Gaps = 88/580 (15%)
Query: 95 NTAQANHTGFYSCKYLAVPTSKKKETESAIYIFISD-TGRPFVEMYSEIPEIIHMTEGRE 153
N ++A +G Y C S + + ++ + +GR + + EG+
Sbjct: 87 NPSEAKDSGHYQCLATNTVGSILSREATLQFAYLGNFSGRT--------RSAVSVREGQG 138
Query: 154 LVIPCRVT--SPNITVT--LKKFPLDTLIPDGKRIIWDSRKGFIISNATYKEIGLLTC-- 207
+V+ C SP I + +FP + D +R I IS ++G C
Sbjct: 139 VVLMCSPPPHSPEIIYSWVFNEFP-SFVAEDSRRFISQETGNLYISKVQTSDVGSYICLV 197
Query: 208 -EATVNGH-LYKTNYLTHRQTNTIID----VQISTPRPVKLLRGHTLVLNCTAT-TPLNT 260
N L LT R + + +++ P V +G T+ + C A P+ T
Sbjct: 198 KNTVTNARVLSPPTPLTLRNDGVMGEYEPKIEVHFPFTVTAAKGTTVKMECFALGNPVPT 257
Query: 261 RVQMTWSYPDEKNKRASVRRRIDQSNSHANIFYSVLTIDKMQNKDKGLYTCRVRSGPSFK 320
+TW + N + R+ +S + VL I +Q D G+Y CR +
Sbjct: 258 ---ITWM---KVNGYIPSKARLRKSQA-------VLEIPNVQLDDAGIYECRAENSRGKN 304
Query: 321 SVNTSVHIYDKAFITVKHRKQQVLETVAGKRS-YRLSMKVKAFPSPEVVWLKDGLPATEK 379
S + +Y T H +++ +T S R K P P WLK+G+P + +
Sbjct: 305 SFRGQLQVY-----TYPHWVEKLNDTQLDSGSPLRWECKATGKPRPTYRWLKNGVPLSPQ 359
Query: 380 SARYLTRGYSLIIKDVTEEDAGNYTILLSIKQSNVFKNLTATLIVNVKPQIYEKAVSSFP 439
S + G L+I +V + DAG Y L K ++ + ++ + A++
Sbjct: 360 SRVEMVNGV-LMIHNVNQSDAGMYQCLAENKYGAIYASAELKILASAP----TFALNQLK 414
Query: 440 DPALYPLGSRQILTCTAYGIPQPTIKWFWHPCNHNHSEARCDFCSNNEESFILDADSNMG 499
+ ++ C G P+PTI W G
Sbjct: 415 KTIIVTKDQEVVIECKPQGSPKPTISW------------------------------KKG 444
Query: 500 NRIESITQRMAII-EGKNKMASTLVVADSRISGIYICIASNKVGTVGRNISFYITDVPNG 558
+R +R+AI+ +G ++ + A G Y+C N G+ S + + P
Sbjct: 445 DRAVRENKRIAILPDGSLRILN----ASKSDEGKYVCRGENVFGSAEIIASLSVKE-PTR 499
Query: 559 FHVNLEKMP-TEGEDLKLSCTVNKFLYRDVTWILLRTVNNRTMHYSISKQKMAITKEHSI 617
+ ++ T GE + L+C DVT+ T+ + + + + +
Sbjct: 500 IELTPKRTELTVGESIVLNCKAIHDASLDVTFYW--TLKGQPIDFEEEGGHFESIRAQAS 557
Query: 618 TLNLTIMNVSLQDSGTYACRARNVYTGEEILQKKEITIRG 657
+ +L I N+ L +G Y CR + T + + + E+ +RG
Sbjct: 558 SADLMIRNILLMHAGRYGCRVQT--TADSVSDEAELLVRG 595
Score = 38.9 bits (89), Expect = 0.016
Identities = 54/237 (22%), Positives = 95/237 (40%), Gaps = 38/237 (16%)
Query: 92 LTLNTAQANHTGFYSC----KYLAVPTSKKKETESAIYIFISDTGRPFVEMYSEIPEIIH 147
L ++ + G Y C KY A+ S + + ++ F +++ + I
Sbjct: 369 LMIHNVNQSDAGMYQCLAENKYGAIYASAELKILASAPTFA----------LNQLKKTII 418
Query: 148 MTEGRELVIPCRVT-SPNITVTLKKFPLDTLIPDGKRIIWDSRKGFIISNATYKEIGLLT 206
+T+ +E+VI C+ SP T++ KK D + + KRI I NA+ + G
Sbjct: 419 VTKDQEVVIECKPQGSPKPTISWKKG--DRAVRENKRIAILPDGSLRILNASKSDEGKYV 476
Query: 207 CEA-TVNGHLYKTNYLTHRQTNTIIDVQISTPRPVKLLRGHTLVLNCTATTPLNTRVQMT 265
C V G L+ ++ I TP+ +L G ++VLNC A + V
Sbjct: 477 CRGENVFGSAEIIASLSVKEPTRIE----LTPKRTELTVGESIVLNCKAIHDASLDVTFY 532
Query: 266 WS-------YPDEKNKRASVRRRIDQSNSHANIFYSVLTIDKMQNKDKGLYTCRVRS 315
W+ + +E S+R + ++ L I + G Y CRV++
Sbjct: 533 WTLKGQPIDFEEEGGHFESIRAQASSAD---------LMIRNILLMHAGRYGCRVQT 580
Score = 37.0 bits (84), Expect = 0.061
Identities = 49/226 (21%), Positives = 86/226 (38%), Gaps = 44/226 (19%)
Query: 439 PDPALYPLGSRQ---ILTCTAYGIPQPTIKWFWHPCNHNHSEARCDFCSNNEESFILDAD 495
PD ++P S + L C G P P+ +W N L++D
Sbjct: 31 PDDIIFPTDSDEKKVALNCEVRGNPVPSYRWL-----------------RNGTEIDLESD 73
Query: 496 SNMGNRIESITQRMAIIEGKNKMASTLVVADSRISGIYICIASNKVGTV-GRNISFYITD 554
R ++I+G +++ ++++ SG Y C+A+N VG++ R +
Sbjct: 74 -----------YRYSLIDGTFIISNP---SEAKDSGHYQCLATNTVGSILSREATLQFAY 119
Query: 555 VPN-GFHVNLEKMPTEGEDLKLSCTVNKFLYRDVTWILLRTVNNRTMHYSISKQKMAITK 613
+ N EG+ + L C+ I+ V N + + I++
Sbjct: 120 LGNFSGRTRSAVSVREGQGVVLMCSPPPHSPE----IIYSWVFNEFPSFVAEDSRRFISQ 175
Query: 614 EHSITLNLTIMNVSLQDSGTYACRARNVYTGEEILQ-KKEITIRGE 658
E T NL I V D G+Y C +N T +L +T+R +
Sbjct: 176 E---TGNLYISKVQTSDVGSYICLVKNTVTNARVLSPPTPLTLRND 218
>gi|21359935 Down syndrome cell adhesion molecule like 1 [Homo
sapiens]
Length = 2113
Score = 75.1 bits (183), Expect = 2e-13
Identities = 80/309 (25%), Positives = 120/309 (38%), Gaps = 55/309 (17%)
Query: 355 LSMKVKAFPSPEVVWLKDGLPATEKSARYLTRGYSLIIKDVTEEDAGNYTILLSIKQSNV 414
L +P P + WLKDG P S R+ R L I D+ ED+G Y + +N
Sbjct: 305 LPCTASGYPIPAIRWLKDGRPLPADS-RWTKRITGLTISDLRTEDSGTYIC----EVTNT 359
Query: 415 FKNLTATLIVNVKPQIYEKAVSSFPDPALYPLGSRQILTCTAYGIPQPTIKWFWHPCNHN 474
F + AT I+ V ++ V+ P +GS IL+C G P+ TI+W+
Sbjct: 360 FGSAEATGILMVIDPLH---VTLTPKKLKTGIGSTVILSCALTGSPEFTIRWY------- 409
Query: 475 HSEARCDFCSNNEESFILDADSNMGNRIESITQRMAIIEGKNKMASTLVVADSRISGIYI 534
N E + D E+I+ I G + + A SG Y
Sbjct: 410 ----------RNTELVLPD---------EAIS-----IRGLSNETLLITSAQKSHSGAYQ 445
Query: 535 CIASNKVGTVGRNISFYITD-VPNGFHVNLEKMPTEGEDLKLSCTVNKFLYRDVTWIL-- 591
C A+ K T + D P EK+ GE L C VTW L
Sbjct: 446 CFATRKAQTAQDFAIIALEDGTPRIVSSFSEKVVNPGEQFSLMCAAKGAPPPTVTWALDD 505
Query: 592 ---LRTVNNRTMHYSISKQKMAITKEHSITLNLTIMNVSLQDSGTYACRARNVYTGEEIL 648
+R ++RT Y++S + + ++ + ++D G Y C ARN+ E
Sbjct: 506 EPIVRDGSHRTNQYTMS--------DGTTISHMNVTGPQIRDGGVYRCTARNLVGSAE-- 555
Query: 649 QKKEITIRG 657
+ I +RG
Sbjct: 556 YQARINVRG 564
Score = 59.3 bits (142), Expect = 1e-08
Identities = 131/576 (22%), Positives = 224/576 (38%), Gaps = 89/576 (15%)
Query: 91 TLTLNTAQANHTGFYSCKYLAVPTSKKKETESAIYIFISDTGRP-FVEMYSEIPEIIHMT 149
TL + +AQ +H+G Y C ++K +T I + G P V +SE ++++
Sbjct: 430 TLLITSAQKSHSGAYQCF-----ATRKAQTAQDFAIIALEDGTPRIVSSFSE--KVVNPG 482
Query: 150 EGRELVIPCR-VTSPNITVTLKKFPLDTLIPDGKRIIWDSRKGFIISNATYKEIGLLTCE 208
E L+ + P +T L P ++ DG + +S+ T +T
Sbjct: 483 EQFSLMCAAKGAPPPTVTWALDDEP---IVRDGSH----RTNQYTMSDGTTISHMNVTGP 535
Query: 209 ATVNGHLYK---TNYLTHRQTNTIIDVQISTPRPVKLLRGHTLVLNCTATTPLNTRVQMT 265
+G +Y+ N + + I+V+ P ++ +R T V T +N RV
Sbjct: 536 QIRDGGVYRCTARNLVGSAEYQARINVR--GPPSIRAMRNITAVAG--RDTLINCRVIGY 591
Query: 266 WSYPDEKNKRASVRRRIDQSNSHANIFYSVLTI---DKMQNKDKGLYTCRVRSGPSFKSV 322
Y + K A + ++H + + T+ D + D+G Y C V P S+
Sbjct: 592 PYYSIKWYKDALL-----LPDNHRQVVFENGTLKLTDVQKGMDEGEYLCSVLIQPQL-SI 645
Query: 323 NTSVHIYDKAFITVKHRKQQVLETVAGKRSYRLSMKVKAFPSPEVVWLKD------GLPA 376
+ SVH+ K + + + G+ Y + + W KD G
Sbjct: 646 SQSVHVAVK--VPPLIQPFEFPPASIGQLLYIPCVVSSGDMPIRITWRKDGQVIISGSGV 703
Query: 377 TEKSARYLTRGYSLIIKDVTEEDAGNYTILLSIKQSNVFKNLTATLIVNVKPQIYEKAVS 436
T +S +++ SL I V+ + GNYT + S + V + LIV V P+ V
Sbjct: 704 TIESKEFMS---SLQISSVSLKHNGNYTCIASNAAATVSRE--RQLIVRVPPRF---VVQ 755
Query: 437 SFPDPALYPLGSRQILTCTAYGIPQPTIKWFWHPCNHNHSEARCDFCSNNEESFILDADS 496
+Y G +L C+ G P P + W H++ S N + +
Sbjct: 756 PNNQDGIY--GKAGVLNCSVDGYPPPKVMW-------KHAKG-----SGNPQQY------ 795
Query: 497 NMGNRIESITQRMAIIEGKNKMASTLVVADSRISGIYICIASNKVGTVGRNISFYITDVP 556
+T R+ I+ + + ++ D G Y+C ASN VGT F +P
Sbjct: 796 ----HPVPLTGRIQILPNSSLLIRHVLEED---IGYYLCQASNGVGTDISKSMFLTVKIP 848
Query: 557 NGF--HVNLEKMPTEGEDLKLSCTVNKFLYRDVTWILLRTV--NNRTMHYSISKQKMAIT 612
H N + +G +L+CT + W TV +R M Y+I+ T
Sbjct: 849 AMITSHPN-TTIAIKGHAKELNCTARGERPIIIRWEKGDTVIDPDRVMRYAIA------T 901
Query: 613 KEH--SITLNLTIMNVSLQDSGTYACRARNVYTGEE 646
K++ + L + DS ++C A N Y GE+
Sbjct: 902 KDNGDEVVSTLKLKPADRGDSVFFSCHAINSY-GED 936
Score = 53.5 bits (127), Expect = 6e-07
Identities = 117/519 (22%), Positives = 192/519 (36%), Gaps = 74/519 (14%)
Query: 151 GRELVIPCRVT-SPNITVTLKKFPLDTLIPDGKRIIWDSRKGFIISNATYKEIGLLTCEA 209
G +++ C +T SP T+ + L + I S + +I++A G C A
Sbjct: 389 GSTVILSCALTGSPEFTIRWYRNTELVLPDEAISIRGLSNETLLITSAQKSHSGAYQCFA 448
Query: 210 TVNGHLYKTNYLTHRQTNTIIDVQISTPRPVKLLR------GHTLVLNCTAT-TPLNTRV 262
T Q II ++ TPR V G L C A P T
Sbjct: 449 TRKAQT--------AQDFAIIALEDGTPRIVSSFSEKVVNPGEQFSLMCAAKGAPPPT-- 498
Query: 263 QMTWSYPDEKNKRASVRRRIDQSNSHANIFYSVLTIDKMQNKDKGLYTCRVRSGPSFKSV 322
+TW+ DE R R + S S + + Q +D G+Y C R+
Sbjct: 499 -VTWALDDEPIVRDGSHRTNQYTMSDGTTI-SHMNVTGPQIRDGGVYRCTARNLVGSAEY 556
Query: 323 NTSVHIYDKAFITVKHRKQQVLETVAGKRSYRLSMKVKAFPSPEVVWLKDGLPATEKSAR 382
+++ I R + + VAG R ++ +V +P + W KD L + +
Sbjct: 557 QARINVRGPPSI----RAMRNITAVAG-RDTLINCRVIGYPYYSIKWYKDALLLPDNHRQ 611
Query: 383 YLTRGYSLIIKDVTEE-DAGNYTILLSIKQSNVFKNLTATLIVNVKPQIYEKAVSSFPDP 441
+ +L + DV + D G Y + I Q + + + + V V P I FP
Sbjct: 612 VVFENGTLKLTDVQKGMDEGEYLCSVLI-QPQLSISQSVHVAVKVPPLIQP---FEFPPA 667
Query: 442 ALYPLGSRQILTCTAYGIPQPTIKWFWHPCNHNHSEARCDFCSNNEESFILDADSNMGNR 501
++ G + C P I+ W ++ ++ + S +
Sbjct: 668 SI---GQLLYIPCVVSSGDMP-IRITWR-----------------KDGQVIISGSGV--- 703
Query: 502 IESITQRMAIIEGKNKMASTLVVADS-RISGIYICIASNKVGTVGRNISFYITDVPNGFH 560
IE K M+S + + S + +G Y CIASN TV R I VP F
Sbjct: 704 ---------TIESKEFMSSLQISSVSLKHNGNYTCIASNAAATVSRERQL-IVRVPPRFV 753
Query: 561 VNLEKMP-TEGEDLKLSCTVNKFLYRDVTWILLRTVNNRTMHYSISKQKMAITKEHSITL 619
V G+ L+C+V+ + V W + N ++ + +T I
Sbjct: 754 VQPNNQDGIYGKAGVLNCSVDGYPPPKVMWKHAKGSGNPQQYHPV-----PLTGRIQILP 808
Query: 620 N--LTIMNVSLQDSGTYACRARNVYTGEEILQKKEITIR 656
N L I +V +D G Y C+A N G +I + +T++
Sbjct: 809 NSSLLIRHVLEEDIGYYLCQASN-GVGTDISKSMFLTVK 846
Score = 52.8 bits (125), Expect = 1e-06
Identities = 85/398 (21%), Positives = 147/398 (36%), Gaps = 68/398 (17%)
Query: 245 GHTLVLNCTATTPLNTRVQMTWSYPDEKNKRASVRRRIDQSNSHANIFYSVLTIDKMQNK 304
GHT+ L CTA+ YP + R + ++S + LTI ++ +
Sbjct: 300 GHTVELPCTAS-----------GYPIPAIRWLKDGRPLP-ADSRWTKRITGLTISDLRTE 347
Query: 305 DKGLYTCRVRSGPSFKSVNTSVHIYDKAFITVKHRKQQVLETVAGKRSYRLSMKVKAFPS 364
D G Y C V + + + D +T+ +K L+T G + LS + P
Sbjct: 348 DSGTYICEVTNTFGSAEATGILMVIDPLHVTLTPKK---LKTGIGS-TVILSCALTGSPE 403
Query: 365 PEVVWLKDG---LPATEKSARYLTRGYSLIIKDVTEEDAGNYTILLSIKQSNVFKNLTAT 421
+ W ++ LP S R L+ +L+I + +G Y + +++ ++
Sbjct: 404 FTIRWYRNTELVLPDEAISIRGLSNE-TLLITSAQKSHSGAYQCFAT-RKAQTAQDFAII 461
Query: 422 LIVNVKPQIYEKAVSSFPDPALYPLGSRQILTCTAYGIPQPTIKWFWHPCNHNHSEARCD 481
+ + P+I VSSF + + P G + L C A G P PT+ W
Sbjct: 462 ALEDGTPRI----VSSFSEKVVNP-GEQFSLMCAAKGAPPPTVTW--------------- 501
Query: 482 FCSNNEESFILDADSNMGNRIESITQRMAIIEGKNKMASTLVVADSRISGIYICIASNKV 541
+ ++E + D T + + +G + R G+Y C A N V
Sbjct: 502 --ALDDEPIVRDGSHR--------TNQYTMSDGTTISHMNVTGPQIRDGGVYRCTARNLV 551
Query: 542 GTVGRNISFYITDVPNGFHVNLEKMPTEGEDLKLSCTVNKFLYRDVTW---ILLRTVNNR 598
G+ + P+ G D ++C V + Y + W LL N+R
Sbjct: 552 GSAEYQARINVRGPPS-IRAMRNITAVAGRDTLINCRVIGYPYYSIKWYKDALLLPDNHR 610
Query: 599 TMHYSISKQKMAITKEHSITLNLTIMNVSLQDSGTYAC 636
+ + + TL LT + + D G Y C
Sbjct: 611 QVVF------------ENGTLKLTDVQKGM-DEGEYLC 635
Score = 38.5 bits (88), Expect = 0.021
Identities = 69/286 (24%), Positives = 101/286 (35%), Gaps = 53/286 (18%)
Query: 367 VVWLKDGLPATEKSARYLTRGYSLIIKDVTEEDA-GNYTILLSIKQSNVFKNLT-ATLIV 424
V W KD + + ++T L I DV +EDA Y + K S + A L V
Sbjct: 219 VSWEKDTVSIIPEHRFFITYHGGLYISDVQKEDALSTYRCITKHKYSGETRQSNGARLSV 278
Query: 425 NVKPQIYEKAVSSFPDPALYPLGSRQILTCTAYGIPQPTIKWFWHPCNHNHSEARCDFCS 484
+ + F ++ G L CTA G P P I+W
Sbjct: 279 TDPAESIPTILDGFHSQEVW-AGHTVELPCTASGYPIPAIRWL----------------- 320
Query: 485 NNEESFILDADSNMGNRIESITQRMAIIEGKNKMASTLVVADSRISGIYICIASNKVGTV 544
++ L ADS RI +T S L D SG YIC +N G+
Sbjct: 321 --KDGRPLPADSRWTKRITGLT------------ISDLRTED---SGTYICEVTNTFGSA 363
Query: 545 GRNISFYITDVPNGFHVNL--EKMPTE-GEDLKLSCTVNKFLYRDVTWILLRTVNNRTMH 601
+ D HV L +K+ T G + LSC + + W R
Sbjct: 364 EATGILMVID---PLHVTLTPKKLKTGIGSTVILSCALTGSPEFTIRWY-------RNTE 413
Query: 602 YSISKQKMAITKEHSITLNLTIMNVSLQDSGTYACRA-RNVYTGEE 646
+ + ++I + TL +T + SG Y C A R T ++
Sbjct: 414 LVLPDEAISIRGLSNETLLIT--SAQKSHSGAYQCFATRKAQTAQD 457
Score = 38.5 bits (88), Expect = 0.021
Identities = 70/339 (20%), Positives = 126/339 (37%), Gaps = 61/339 (17%)
Query: 151 GRELVIPCRVTSPNITVTLKKFPLDTL--IPDGKRIIWDSR-----KGFIISNATYKEIG 203
G + +PC T +P+ + + DG+ + DSR G IS+ ++ G
Sbjct: 300 GHTVELPC---------TASGYPIPAIRWLKDGRPLPADSRWTKRITGLTISDLRTEDSG 350
Query: 204 LLTCEATVN-GHLYKTNYLTHRQTNTIID-VQIS-TPRPVKLLRGHTLVLNCTATTPLNT 260
CE T G T L +ID + ++ TP+ +K G T++L+C T +
Sbjct: 351 TYICEVTNTFGSAEATGILM------VIDPLHVTLTPKKLKTGIGSTVILSCALTG--SP 402
Query: 261 RVQMTWSYPDEKNKRASVRRRIDQSNSHANIFYSVLTIDKMQNKDKGLYTCRVRSGPSFK 320
+ W R + D++ S + L I Q G Y C
Sbjct: 403 EFTIRW-------YRNTELVLPDEAISIRGLSNETLLITSAQKSHSGAYQC--------F 447
Query: 321 SVNTSVHIYDKAFITVKHRKQQVLETVAGK-----RSYRLSMKVKAFPSPEVVWLKDGLP 375
+ + D A I ++ +++ + + K + L K P P V W D P
Sbjct: 448 ATRKAQTAQDFAIIALEDGTPRIVSSFSEKVVNPGEQFSLMCAAKGAPPPTVTWALDDEP 507
Query: 376 ATEKSARYLTRGYSLIIKDVTEEDAGNYTILLSIKQSNVFKNLTATLIVNVKPQIYEKAV 435
+ + T Y++ D T N T I+ V++ L+ + + Y+ +
Sbjct: 508 IV-RDGSHRTNQYTM--SDGTTISHMNVT-GPQIRDGGVYRCTARNLVGSAE---YQARI 560
Query: 436 SSFPDPALYPL-------GSRQILTCTAYGIPQPTIKWF 467
+ P++ + G ++ C G P +IKW+
Sbjct: 561 NVRGPPSIRAMRNITAVAGRDTLINCRVIGYPYYSIKWY 599
Score = 35.4 bits (80), Expect = 0.18
Identities = 40/154 (25%), Positives = 62/154 (40%), Gaps = 14/154 (9%)
Query: 346 TVAGKRSYRLSMKVKAFPSPEVVWLKDG----LPATEKSARYLTRGYSLIIKDVTEEDAG 401
T + RL P+P V W KD +P + R + +L+++ V ED+G
Sbjct: 1360 TTPWMKDVRLPCNSVGDPAPAVKWTKDSEDSAIPVSMDGHRLIHTNGTLLLRAVKAEDSG 1419
Query: 402 NYTILLSIKQSNVFKNLTATLIVNVKPQIYEKAVSSFPDPALYPLGSRQILTCTAYGIPQ 461
YT + + F + L+V V P VS S LT
Sbjct: 1420 YYT--CTATNTGGFDTIIVNLLVQVPPDQPRLTVSK-------TSASSITLTWIPGDNGG 1470
Query: 462 PTIKWFWHPCNHNHSEARCD-FCSNNEESFILDA 494
+I+ F + ++SE D F S++E SF LD+
Sbjct: 1471 SSIRGFVLQYSVDNSEEWKDVFISSSERSFKLDS 1504
>gi|169177000 PREDICTED: hemicentin 2 [Homo sapiens]
Length = 3783
Score = 72.8 bits (177), Expect = 1e-12
Identities = 84/324 (25%), Positives = 126/324 (38%), Gaps = 37/324 (11%)
Query: 149 TEGRELVIPCRVT-SPNITVTLKKFPLDTLIPDGKRIIWDSRKGFIISNATYKEIGLLTC 207
TEG +PC+ SP +T K +GK I S + ++ N ++ G TC
Sbjct: 2768 TEGSHAFLPCKARGSPEPNITWDKDGQPVSGAEGKFTIQPSGE-LLVKNLEGQDAGTYTC 2826
Query: 208 EA-TVNGHLYKTNYLTHRQTNTIIDVQISTPRPVKLLRGHTLVLNCTATTPLNTRVQMTW 266
A G + +LT ++ V + P L G L L C A R+ T
Sbjct: 2827 TAENAVGRARRRVHLTI----LVLPVFTTLPGDRSLRLGDRLWLRCAARGSPTPRIGWT- 2881
Query: 267 SYPDEKNKRASVRRRIDQSNSHANIFYSVLTIDKMQNKDKGLYTCRVRSGPSFKSVNTSV 326
N R +Q S L + +D G Y C + + V
Sbjct: 2882 -----VNDRPVTEGVSEQDGG------STLQRAAVSREDSGTYVCWAENRVGRTQAVSFV 2930
Query: 327 HIYDKAFITVKHRKQQVLETVAGKRSYRLSMKVKAFPSPEVVWLKDGLPATEKSARYLTR 386
H+ + A + ++E V G S +L V+ P P++ W+KDGLP R+ +
Sbjct: 2931 HVKE-APVLQGEAFSYLVEPVGG--SIQLDCVVRGDPVPDIHWIKDGLPLRGSHLRHQLQ 2987
Query: 387 GYSLIIKDVTEEDAGNYTIL----LSIKQSNVFKNLTATLIVNVKPQIYEKAVSSFPDPA 442
SL I+ +DAG Y L + + + V L + + V+PQ + V S D A
Sbjct: 2988 NGSLTIRRTERDDAGRYQCLAENEMGVAKKVVILVLQSAPVFQVEPQ--DMTVRSGDDVA 3045
Query: 443 LYPLGSRQILTCTAYGIPQPTIKW 466
L C A G P PTI+W
Sbjct: 3046 ---------LRCQATGEPTPTIEW 3060
Score = 70.5 bits (171), Expect = 5e-12
Identities = 83/339 (24%), Positives = 125/339 (36%), Gaps = 65/339 (19%)
Query: 307 GLYTCRVRSGPSFKSVNTSVHIYDKAFITVKHRK-----QQVLETVAGKRSYRLSMKVKA 361
G YTC R N++ + F+TV+ V+ VA + L +
Sbjct: 2641 GRYTCSAR--------NSAGVAHKHVFLTVQASPVVKPLPSVVRAVA-EEEVLLPCEASG 2691
Query: 362 FPSPEVVWLKDGLPATEKSARYLTRGYSLIIKDVTEEDAGNYTILLSIKQSNVFKNLTAT 421
P P + W K+GL + + G L I + EDAGNY L I +++ + T
Sbjct: 2692 IPRPTITWQKEGLNVATGVSTQVLPGGQLRIAHASPEDAGNY---LCIAKNSAGSAMGKT 2748
Query: 422 LIVNVKPQIYEKAVSSFPDPALYPLGSRQILTCTAYGIPQPTIKWFWHPCNHNHSEARCD 481
+V P + E + PD + GS L C A G P+P I W
Sbjct: 2749 RLVVQVPPVIE---NGLPDLSTTE-GSHAFLPCKARGSPEPNITW--------------- 2789
Query: 482 FCSNNEESFILDADSNMGNRIESITQRMAIIEGKNKMASTLVVADSRISGIYICIASNKV 541
D D G + + I + L + + +G Y C A N V
Sbjct: 2790 -----------DKD---GQPVSGAEGKFTIQPSGELLVKNL---EGQDAGTYTCTAENAV 2832
Query: 542 GTVGRNISFYITDVPNGFHVNLEKMPTEGEDLKLSCTVNKFLYRDVTWILLRTVNNRTMH 601
G R + I +P + ++ G+ L L C + W TVN+R +
Sbjct: 2833 GRARRRVHLTILVLPVFTTLPGDRSLRLGDRLWLRCAARGSPTPRIGW----TVNDRPVT 2888
Query: 602 YSISKQKMAITKEHSITLNLTIMNVSLQDSGTYACRARN 640
+S+Q T + + VS +DSGTY C A N
Sbjct: 2889 EGVSEQDGGSTLQRAA--------VSREDSGTYVCWAEN 2919
Score = 65.5 bits (158), Expect = 2e-10
Identities = 84/352 (23%), Positives = 124/352 (35%), Gaps = 57/352 (16%)
Query: 296 LTIDKMQNKDKGLYTCRV--RSGPSFKSVNTSVHIYDKAFITVKHRKQQVLETVAGKRSY 353
L + + + D G+YTC +G K V SV + AF Q + G ++
Sbjct: 1711 LQLGRARLSDSGMYTCEALNAAGRDQKLVQLSV-LVPPAFRQAPRGPQDAVLVRVGDKAV 1769
Query: 354 RLSMKVKAFPSPEVVWLKDGLPAT-EKSARYLTRGYSLIIKDVTEEDAGNYTILLSIKQS 412
LS + A P P V W KDG P + + L G L I++ D G Y S K S
Sbjct: 1770 -LSCETDALPEPTVTWYKDGQPLVLAQRTQALRGGQRLEIQEAQVSDKGLY----SCKVS 1824
Query: 413 NVFKNL--TATLIVNVKPQIYEKAVSSFPDPALYPLGSRQILTCTAYGIPQPTIKWFWHP 470
NV T TL V V P + A GS +LTC G+P PT+ W
Sbjct: 1825 NVAGEAVRTFTLTVQVPPTFENPKTETVSQVA----GSPLVLTCDVSGVPAPTVTWL--- 1877
Query: 471 CNHNHSEARCDFCSNNEESFILDADSNMGNRIESITQRMAIIEGKNKMASTLVVADSRIS 530
+ES + G S L A +
Sbjct: 1878 --------------------------KDRMPVESSAVHGVVSRGGRLQLSRLQPAQ---A 1908
Query: 531 GIYICIASNKVGTVGRNISFYITDVP--NGFHVNLEKMPTEGEDLKLSCTVNKFLYRDVT 588
G Y C+A N ++ + P V E EG++++L C + DV
Sbjct: 1909 GTYTCVAENTQAEARKDFVVAVLVAPRIRSSGVAREHHVLEGQEVRLDCEADGQPPPDVA 1968
Query: 589 WILLRTVNNRTMHYSISKQKMAITKEHSITLNLTIMNVSLQDSGTYACRARN 640
W+ + + M + + + +L + + D+G Y C A N
Sbjct: 1969 WLKDGSPLGQDMGPHL--------RFYLDGGSLVLKGLRASDAGAYTCVAHN 2012
Score = 63.5 bits (153), Expect = 6e-10
Identities = 83/365 (22%), Positives = 131/365 (35%), Gaps = 71/365 (19%)
Query: 296 LTIDKMQNKDKGLYTCRVRSGPSFKSVNTSVHIYDKAFITVKHRKQQVLETVAGKRSYRL 355
L I K+Q D G++TC S N ++ + + + V+ V L
Sbjct: 2087 LRISKVQLADAGIFTCVAASPAGVADRNFTLQVQVPPVLEPVEFQNDVV--VVRGSLVEL 2144
Query: 356 SMKVKAFPSPEVVWLKDGLPATEKSARYLTRGYSLIIKDVTEEDAGNYTILLSIKQSNVF 415
+ + P P V W+KDG P +S L +G SL ++ V D+G Y+ + +
Sbjct: 2145 PCEARGVPLPLVSWMKDGEPLLSQS---LEQGPSLQLEAVGAGDSGTYSCVAVSEAGEAR 2201
Query: 416 KNLTATLIVNVKPQIYEKAVSSFPDPALYPLGSRQILTCTAYGIPQPTIKWFWHPCNHNH 475
++ T++ P I + S P G+ L C A G PQP I W H
Sbjct: 2202 RHFQLTVME--PPHIED---SGQPTELSLTPGAPMELLCDAQGTPQPNITW--------H 2248
Query: 476 SEARCDFCSNNEESFILDADSNMGNRIESITQRMAIIEGKNKMASTLVVADSRISGIYIC 535
+ Q + +E ++ L V D +G+Y C
Sbjct: 2249 KDG----------------------------QALTRLENNSRATRVLRVRD---AGLYTC 2277
Query: 536 IASNKVGTVGRNISFYITDVPN-------GFHVNLEKMPTEGEDLKLSCTVNKFLYRDVT 588
+A + G + ++ + PN F V L L L C+V +T
Sbjct: 2278 LAESPAGAIEKSFRVRVQAPPNIVGPRGPRFVVGLAP-----GQLVLECSVEAEPAPKIT 2332
Query: 589 WILLRTVNNRTMHYSISKQKMAITKEHSITLNLTIMNVSLQDSGTYACRARNVYTGEEIL 648
W I Q+ A T+ L + +S DSG Y+C ARN +
Sbjct: 2333 W----------HRDGIVLQEDAHTQFPERGRFLQLQALSTADSGDYSCTARNAAGSTSVA 2382
Query: 649 QKKEI 653
+ EI
Sbjct: 2383 FRVEI 2387
Score = 61.6 bits (148), Expect = 2e-09
Identities = 116/594 (19%), Positives = 215/594 (36%), Gaps = 125/594 (21%)
Query: 91 TLTLNTAQANHTGFYSCKYLAVPTSKKKETESAIYIFISDTGRPFVEMYSEIPEIIHMTE 150
+L + AQA HTG YSC +A + + E + + + + E+ ++ + ++T
Sbjct: 1031 SLHVERAQAAHTGRYSC--VAENLAGRAERKFELSVLVPP------ELIGDLDPLTNITA 1082
Query: 151 GRE--LVIPCR---VTSPNITVTLKKFPL----DTLIPDGKRIIWDSRKGFIISNATYKE 201
L + C + P I + P+ DT + G ++ ++ ++
Sbjct: 1083 ALHSPLTLLCEAMGIPPPAIRWFRGEEPVSPGEDTYLLAGGWMLK-------MTQTQEQD 1135
Query: 202 IGLLTCEATVNGHLYKTNYLTHRQTNTIIDVQISTPRPVKLLRGHTLVLNCTATTPLNTR 261
GL +C A+ + N+ I+ + +K+L G T L C T + +
Sbjct: 1136 SGLYSCLASNEAGEARRNFSVEVLVPPSIENE-DLEEVIKVLDGQTAHLMCNVTG--HPQ 1192
Query: 262 VQMTWSYPDEKNKRASVRRRIDQSNSHANIFYSVLTIDKMQNKDKGLYTCRVRS--GPSF 319
++TW R H + +L + + G Y+C + G
Sbjct: 1193 PKLTWFKDGRPLARGDAH--------HISPDGVLLQVLQANLSSAGHYSCIAANAVGEKT 1244
Query: 320 KSVNTSVHIYDKAFITVKHRKQQVLETVAGKRSYRLSMKVKAFPSPEVVWLKDGLP-ATE 378
K SV + + + + TV L + AFPSP + W+KDG P
Sbjct: 1245 KHFQLSVLLAPTILGGAEDSADEEV-TVTVNNPISLICEALAFPSPNITWMKDGAPFEAS 1303
Query: 379 KSARYLTRGYSLIIKDVTEEDAGNYTILLSIKQSNVFKNLTATLIVNVKPQIYEKAVSSF 438
++ + L + L I + +EDAG YT +++ + KN ++ + P I +
Sbjct: 1304 RNIQLLPGTHGLQILNAQKEDAGQYTCVVTNELGEAVKNYHVEVL--IPPSISK------ 1355
Query: 439 PDPALYPLGSRQI---------LTCTAYGIPQPTIKWFWHPCNHNHSEARCDFCSNNEES 489
D L +G +++ L C ++ +P PTI+W+
Sbjct: 1356 -DDPLAEVGVKEVKTKVNSTLTLECESWAVPPPTIRWY---------------------- 1392
Query: 490 FILDADSNMGNRIESITQRMAIIEGKNKMASTLVVADSRISGIYICIASNKVGTVGRNIS 549
G + ++ + EG+ V+D SG Y+C+A+N G ++ +
Sbjct: 1393 -------KDGQPVTPSSRLQVLGEGRLLQIQPTQVSD---SGRYLCVATNVAGEDDQDFN 1442
Query: 550 FYITDVP-----NGFHVNLEKMPTEGE---------------DLKLSCTVNKFLYRDVTW 589
I P F E + E E L C N D+TW
Sbjct: 1443 VLIQVPPMFQKVGDFSAAFEILSREEEARGGVTEYREIVENNPAYLYCDTNAIPPPDLTW 1502
Query: 590 ILLRTVNNRTMHYSISKQKMAITKEHSITLNLTIMNVSL---QDSGTYACRARN 640
Q ++ E S+ ++ + L +++G Y+C+A N
Sbjct: 1503 YR-------------EDQPLSAGDEVSVLQGGRVLQIPLVRAENAGRYSCKASN 1543
Score = 61.2 bits (147), Expect = 3e-09
Identities = 126/589 (21%), Positives = 218/589 (37%), Gaps = 105/589 (17%)
Query: 69 KESERLSITKSACGRNGKQFCSTLTLNTAQANHTGFYSCKYLAVPTSKKKETESAIYIFI 128
K+S+ LS+ + G TL L A+ + +G Y+C+ L +K + ++ +
Sbjct: 1691 KDSQALSLGEEVFLLPGTH---TLQLGRARLSDSGMYTCEALNAAGRDQKLVQLSVLV-- 1745
Query: 129 SDTGRPFVEMYSEIPE-IIHMTEGRELVIPCRVTS-PNITVTLKKFPLDTLIPDGKRIIW 186
P P+ + + G + V+ C + P TVT K DG+ ++
Sbjct: 1746 ----PPAFRQAPRGPQDAVLVRVGDKAVLSCETDALPEPTVTWYK--------DGQPLVL 1793
Query: 187 DSRKGFI-------ISNATYKEIGLLTCEAT-VNGHLYKTNYLTHRQTNTIIDVQISTPR 238
R + I A + GL +C+ + V G +T LT + T + + T
Sbjct: 1794 AQRTQALRGGQRLEIQEAQVSDKGLYSCKVSNVAGEAVRTFTLTVQVPPTFENPKTET-- 1851
Query: 239 PVKLLRGHTLVLNCTAT-TPLNTRVQMTWSYPDEKNKRASVRRRIDQSNSHANIFYSVLT 297
V + G LVL C + P T +TW + ++V + + L
Sbjct: 1852 -VSQVAGSPLVLTCDVSGVPAPT---VTWLKDRMPVESSAVHGVVSRGGR--------LQ 1899
Query: 298 IDKMQNKDKGLYTCRVRS--GPSFKSVNTSVHIYDKAFITVKHRKQQVLETVAGKRSYRL 355
+ ++Q G YTC + + K +V + + + R+ VLE + RL
Sbjct: 1900 LSRLQPAQAGTYTCVAENTQAEARKDFVVAVLVAPRIRSSGVAREHHVLEG----QEVRL 1955
Query: 356 SMKVKAFPSPEVVWLKDGLPATEKSA---RYLTRGYSLIIKDVTEEDAGNYTILLSIKQS 412
+ P P+V WLKDG P + R+ G SL++K + DAG YT +
Sbjct: 1956 DCEADGQPPPDVAWLKDGSPLGQDMGPHLRFYLDGGSLVLKGLRASDAGAYTCVAHNPAG 2015
Query: 413 NVFKNLTATLIVNVKPQIYEKAVSSFPDPALYPLGSRQILTCTAYGIPQPTIKWFWHPCN 472
+ T ++ V P I + A S + G + C G P + W
Sbjct: 2016 EDARLHTVNVL--VPPTIKQGADGS--GTLVSRPGELVTMVCPVRGSPPIHVSWL----- 2066
Query: 473 HNHSEARCDFCSNNEESFILDADSNMGNRIESITQRMAII-EGKNKMASTLVVADSRISG 531
++ L ++QR + G S + +AD +G
Sbjct: 2067 --------------KDGLPL-----------PLSQRTLLHGSGHTLRISKVQLAD---AG 2098
Query: 532 IYICIASNKVGTVGRNISFYITDVPNGFHVNLEK--MPTEGEDLKLSCTVNKFLYRDVTW 589
I+ C+A++ G RN + + P V + + G ++L C V+W
Sbjct: 2099 IFTCVAASPAGVADRNFTLQVQVPPVLEPVEFQNDVVVVRGSLVELPCEARGVPLPLVSW 2158
Query: 590 ILLRTVNNRTMHYSISKQKMAITKEHSITLNLTIMNVSLQDSGTYACRA 638
+ + ++ + E +L L V DSGTY+C A
Sbjct: 2159 M------------KDGEPLLSQSLEQGPSLQLEA--VGAGDSGTYSCVA 2193
Score = 59.3 bits (142), Expect = 1e-08
Identities = 48/172 (27%), Positives = 75/172 (43%), Gaps = 7/172 (4%)
Query: 296 LTIDKMQNKDKGLYTCRVRSGPSFKSVNTSVHIYDKAFITVKHRKQQVLETVAGKRSYRL 355
L + + Q+ D G+YTC+ + T + +Y I + V++ VAG R L
Sbjct: 276 LQLGRAQSSDAGVYTCKASNAVGAAEKATRLDVYVPPTIEGAGGRPYVVKAVAG-RPVAL 334
Query: 356 SMKVKAFPSPEVVWLKDGLPATEKS-ARYLTRGYSLIIKDVTEEDAGNYTILLSIKQSNV 414
+ PSP + W +GLP E + +R T G L ++ E +G Y+ + S
Sbjct: 335 ECVARGHPSPTLSWHHEGLPVAESNESRLETDGSVLRLESPGEASSGLYSCVASSPAGEA 394
Query: 415 FKNLTATLIVNVKPQIYEKAVSSFPDPALYPLGSRQILTCTAYGIPQPTIKW 466
L ++ V V PQ+ V+ +G L C A G P PTI+W
Sbjct: 395 V--LQYSVEVQVPPQL---LVAEGLGQVTTIVGQPLELPCQASGSPVPTIQW 441
Score = 58.9 bits (141), Expect = 1e-08
Identities = 79/364 (21%), Positives = 134/364 (36%), Gaps = 66/364 (18%)
Query: 288 HANIFYSVLTIDKMQNKDKGLYTCRVRS--GPSFKSVNTSVHIYDKAFITVKHRKQQVLE 345
H + +L + + Q +G YTC + G S + + VH+ + R+
Sbjct: 930 HVSAVGRLLYLGQAQLAQEGTYTCECSNVVGNSSQDLQLEVHVPPQI---AGPREPPTQV 986
Query: 346 TVAGKRSYRLSMKVKAFPSPEVVWLKDGLPA-TEKSARYLTRGYSLIIKDVTEEDAGNYT 404
+V L P P V W +DG P E + +G SL ++ G Y+
Sbjct: 987 SVVQDGVATLECNATGKPPPTVTWERDGQPVGAELGLQLQNQGQSLHVERAQAAHTGRYS 1046
Query: 405 ILLSIKQSNVFKNLTATLIVNVKPQIYEKAVSSFPDPALY---PLGSRQILTCTAYGIPQ 461
+ + +++V P++ DP L S L C A GIP
Sbjct: 1047 CVAENLAGRAERKFELSVLV--PPELIGDL-----DPLTNITAALHSPLTLLCEAMGIPP 1099
Query: 462 PTIKWFWHPCNHNHSEARCDFCSNNEESFILDADSNMGNRIESITQRMAIIEGKNKMAST 521
P I+WF + S E++++L G + +TQ
Sbjct: 1100 PAIRWFRGE----------EPVSPGEDTYLL-----AGGWMLKMTQ-------------- 1130
Query: 522 LVVADSRISGIYICIASNKVGTVGRNISFYITDVPNGFHVNLEKM--PTEGEDLKLSCTV 579
+ SG+Y C+ASN+ G RN S + P+ + +LE++ +G+ L C V
Sbjct: 1131 ---TQEQDSGLYSCLASNEAGEARRNFSVEVLVPPSIENEDLEEVIKVLDGQTAHLMCNV 1187
Query: 580 NKFLYRDVTWILLRTVNNRTMHYSISKQKMAITKEHSIT---LNLTIMNVSLQDSGTYAC 636
+TW + +A H I+ + L ++ +L +G Y+C
Sbjct: 1188 TGHPQPKLTWFK-------------DGRPLARGDAHHISPDGVLLQVLQANLSSAGHYSC 1234
Query: 637 RARN 640
A N
Sbjct: 1235 IAAN 1238
Score = 58.9 bits (141), Expect = 1e-08
Identities = 67/302 (22%), Positives = 109/302 (36%), Gaps = 61/302 (20%)
Query: 344 LETVAGKRSYRLSMKVKAFPSPEVVWLKDGLPATEKSARYLTR-GYSLIIKDVTEEDAGN 402
L T G ++ L K + P P + W KDG P + ++ + L++K++ +DAG
Sbjct: 2765 LSTTEGSHAF-LPCKARGSPEPNITWDKDGQPVSGAEGKFTIQPSGELLVKNLEGQDAGT 2823
Query: 403 YTILLSIKQSNVFKNLTATLIVNVKPQIYEKAVSSFPDPALYPLGSRQILTCTAYGIPQP 462
YT + + T++V ++ P LG R L C A G P P
Sbjct: 2824 YTCTAENAVGRARRRVHLTILVL-------PVFTTLPGDRSLRLGDRLWLRCAARGSPTP 2876
Query: 463 TIKWFWHPCNHNHSEARCDFCSNNEESFILDADSNMGNRIESITQRMAIIEGKNKMASTL 522
I W + +R +T+ ++ +G + +
Sbjct: 2877 RIGW------------------------------TVNDR--PVTEGVSEQDGGSTLQRAA 2904
Query: 523 VVADSRISGIYICIASNKVGTVGRNISFYITDVP----NGFHVNLEKMPTEGEDLKLSCT 578
V + SG Y+C A N+VG ++ + P F +E + G ++L C
Sbjct: 2905 VSRED--SGTYVCWAENRVGRTQAVSFVHVKEAPVLQGEAFSYLVEPV---GGSIQLDCV 2959
Query: 579 VNKFLYRDVTWILLRTVNNRTMHYSISKQKMAITKEHSITLNLTIMNVSLQDSGTYACRA 638
V D+ WI + R H Q +LTI D+G Y C A
Sbjct: 2960 VRGDPVPDIHWI-KDGLPLRGSHLRHQLQNG----------SLTIRRTERDDAGRYQCLA 3008
Query: 639 RN 640
N
Sbjct: 3009 EN 3010
Score = 58.5 bits (140), Expect = 2e-08
Identities = 112/564 (19%), Positives = 207/564 (36%), Gaps = 106/564 (18%)
Query: 92 LTLNTAQANHTGFYSCKYLAVPTSKKKETESAIYIFISDTGRPFVEMYSEIPEIIHMTEG 151
L + A H G Y+C +++ + ++F++ P V+ +P ++
Sbjct: 2630 LEIGQALPIHAGRYTC------SARNSAGVAHKHVFLTVQASPVVK---PLPSVVRAVAE 2680
Query: 152 RELVIPCRVTS-PNITVTLKKFPLDTLIPDGKRIIWDSRKGFIISNATYKEIGLLTCEA- 209
E+++PC + P T+T +K L+ +++ + I++A+ ++ G C A
Sbjct: 2681 EEVLLPCEASGIPRPTITWQKEGLNVATGVSTQVLPGGQ--LRIAHASPEDAGNYLCIAK 2738
Query: 210 -TVNGHLYKTNYLTHRQTNTIIDVQISTPRPVKLLRGHTLVLNCTATTPLNTRVQMTWSY 268
+ + KT + Q +I+ + + G L C A + +TW
Sbjct: 2739 NSAGSAMGKTRLVV--QVPPVIENGLPD---LSTTEGSHAFLPCKARG--SPEPNITWDK 2791
Query: 269 PDEKNKRASVRRRIDQSNSHANIFYSVLTIDKMQNKDKGLYTCRVRS--GPSFKSVNTSV 326
+ A + I S L + ++ +D G YTC + G + + V+ ++
Sbjct: 2792 DGQPVSGAEGKFTIQPSGE--------LLVKNLEGQDAGTYTCTAENAVGRARRRVHLTI 2843
Query: 327 HIYDKAFITVKHRKQQVLETVAGKRSYRLSMKV------KAFPSPEVVWLKDGLPATEKS 380
+ V T+ G RS RL ++ + P+P + W + P TE
Sbjct: 2844 LVLP------------VFTTLPGDRSLRLGDRLWLRCAARGSPTPRIGWTVNDRPVTEGV 2891
Query: 381 ARYLTRGYSLIIKDVTEEDAGNYTILLSIKQSNVFKNLTATLIVNVK--PQIYEKAVSSF 438
+ G +L V+ ED+G Y N A V+VK P + +A S
Sbjct: 2892 SEQ-DGGSTLQRAAVSREDSGTYVCWAE----NRVGRTQAVSFVHVKEAPVLQGEAFSYL 2946
Query: 439 PDPALYPLGSRQILTCTAYGIPQPTIKWFWHPCNHNHSEARCDFCSNNEESFILDADSNM 498
+P +G L C G P P I W I D
Sbjct: 2947 VEP----VGGSIQLDCVVRGDPVPDIHW------------------------IKDGLPLR 2978
Query: 499 GNRIESITQRMAIIEGKNKMASTLVVADSRISGIYICIASNKVGTVGRNISFYITDVPNG 558
G+ + Q ++ T+ + +G Y C+A N++G + + + P
Sbjct: 2979 GSHLRHQLQNGSL---------TIRRTERDDAGRYQCLAENEMGVAKKVVILVLQSAPV- 3028
Query: 559 FHVNLEKMPTE-GEDLKLSCTVNKFLYRDVTWILLRTVNNRTMHYSISKQKMAITKEHSI 617
F V + M G+D+ L C + W+ + + +++ + S+
Sbjct: 3029 FQVEPQDMTVRSGDDVALRCQATGEPTPTIEWL-------QAGQPLRASRRLRTLPDGSL 3081
Query: 618 TLNLTIMNVSLQDSGTYACRARNV 641
L NV D+GTY C A N+
Sbjct: 3082 WLE----NVETGDAGTYDCVAHNL 3101
Score = 57.0 bits (136), Expect = 6e-08
Identities = 132/599 (22%), Positives = 209/599 (34%), Gaps = 109/599 (18%)
Query: 94 LNTAQAN--HTGFYSCKYLAVPTSKKKETESAIYIFISDTGRPFVEMYSEIPEIIHMTEG 151
L QAN G YSC +A +K + + ++ T E ++ E + +T
Sbjct: 1219 LQVLQANLSSAGHYSC--IAANAVGEKTKHFQLSVLLAPTILGGAEDSAD--EEVTVTVN 1274
Query: 152 RELVIPCRVT---SPNITVTLKKFPLDTLIPDGKRI-IWDSRKGFIISNATYKEIGLLTC 207
+ + C SPNIT P + + I + G I NA ++ G TC
Sbjct: 1275 NPISLICEALAFPSPNITWMKDGAPFEA----SRNIQLLPGTHGLQILNAQKEDAGQYTC 1330
Query: 208 EATVNGHLYKTNYLTHRQTNTIIDVQISTPRP--------VKLLRGHTLVLNCT--ATTP 257
T NY +I IS P VK TL L C A P
Sbjct: 1331 VVTNELGEAVKNY----HVEVLIPPSISKDDPLAEVGVKEVKTKVNSTLTLECESWAVPP 1386
Query: 258 LNTRVQMTWSYPDEKNKRASVRRRIDQSNSHANIFYSVLTIDKMQNKDKGLYTCRVRS-- 315
R W Y D + S R ++ +L I Q D G Y C +
Sbjct: 1387 PTIR----W-YKDGQPVTPSSRLQVLGEGR-------LLQIQPTQVSDSGRYLCVATNVA 1434
Query: 316 GPSFKSVNTSVHI---------YDKAFITVKHRKQ------QVLETVAGKRSYRLSMKVK 360
G + N + + + AF + ++ + E V +Y L
Sbjct: 1435 GEDDQDFNVLIQVPPMFQKVGDFSAAFEILSREEEARGGVTEYREIVENNPAY-LYCDTN 1493
Query: 361 AFPSPEVVWLKDGLPATE-KSARYLTRGYSLIIKDVTEEDAGNYTILLSIKQSN-VFKNL 418
A P P++ W ++ P + L G L I V E+AG Y S K SN V ++
Sbjct: 1494 AIPPPDLTWYREDQPLSAGDEVSVLQGGRVLQIPLVRAENAGRY----SCKASNEVGEDW 1549
Query: 419 TATLIVNVKPQIYEKAVSSFPDPALYPLGSRQILTCTAYGIPQPTIKWFWHPCNHNHSEA 478
++ + P + + S L C A G P PTI W
Sbjct: 1550 LHYELLVLTPPVILGDTEELVEEVTVNASSTVSLQCPALGNPVPTISWL----------- 1598
Query: 479 RCDFCSNNEESFILDADSNMGNRIESITQRMAIIE-GKNKMASTLVVADSRISGIYICIA 537
N F S + R+ ++E G+ ST VAD+ Y+C+A
Sbjct: 1599 ------QNGLPF-------------SPSPRLQVLEDGQVLQVSTAEVADA---ASYMCVA 1636
Query: 538 SNKVGTVGRNISFYITDVPNGFHVNLEKMPTE-GEDLKLSCTVNKFLYRDVTWILLRTVN 596
N+ G+ + + + P ++LE++ + L C V+ +VTW
Sbjct: 1637 ENQAGSAEKLFTLRVQVPPRIAGLDLEQVTAILNSSVSLPCDVHAHPNPEVTWY------ 1690
Query: 597 NRTMHYSISKQKMAITKEHSITLNLTIMNVSLQDSGTYACRARNVYTGEEILQKKEITI 655
+ S+ ++ + H++ L L DSG Y C A N ++ L + + +
Sbjct: 1691 KDSQALSLGEEVFLLPGTHTLQLG----RARLSDSGMYTCEALNAAGRDQKLVQLSVLV 1745
Score = 56.6 bits (135), Expect = 7e-08
Identities = 65/294 (22%), Positives = 111/294 (37%), Gaps = 53/294 (18%)
Query: 352 SYRLSMKVKAFPSPEVVWLKDGLPATEKSARYLTRG-YSLIIKDVTEEDAGNYTILLSIK 410
S L V A P+PEV W KD + +L G ++L + D+G YT
Sbjct: 1672 SVSLPCDVHAHPNPEVTWYKDSQALSLGEEVFLLPGTHTLQLGRARLSDSGMYTCEALNA 1731
Query: 411 QSNVFKNLTATLIVNVKPQIYEKAVSSFPDPALYPLGSRQILTCTAYGIPQPTIKWFWHP 470
K + +++V P + +A D L +G + +L+C +P+PT+ W+
Sbjct: 1732 AGRDQKLVQLSVLV---PPAFRQAPRGPQDAVLVRVGDKAVLSCETDALPEPTVTWY--- 1785
Query: 471 CNHNHSEARCDFCSNNEESFILDADSNMGNRIESITQRMAIIEGKNKMASTLVVADSRIS 530
+ + +L QR + G + L + ++++S
Sbjct: 1786 --------------KDGQPLVL-------------AQRTQALRGGQR----LEIQEAQVS 1814
Query: 531 --GIYICIASNKVGTVGRNISFYITDVPNGFHVNLEKM-PTEGEDLKLSCTVNKFLYRDV 587
G+Y C SN G R + + P + E + G L L+C V+ V
Sbjct: 1815 DKGLYSCKVSNVAGEAVRTFTLTVQVPPTFENPKTETVSQVAGSPLVLTCDVSGVPAPTV 1874
Query: 588 TWILLR-TVNNRTMHYSISKQKMAITKEHSITLNLTIMNVSLQDSGTYACRARN 640
TW+ R V + +H +S+ L + + +GTY C A N
Sbjct: 1875 TWLKDRMPVESSAVHGVVSRGG-----------RLQLSRLQPAQAGTYTCVAEN 1917
Score = 55.1 bits (131), Expect = 2e-07
Identities = 82/351 (23%), Positives = 122/351 (34%), Gaps = 61/351 (17%)
Query: 296 LTIDKMQNKDKGLYTCRVR--SGPSFKSVNTSVHIYDKAFITVKHRKQQVLETVAGKRSY 353
L I+K+ +D+G+YTC +G S + V K + V + V S
Sbjct: 568 LQIEKVDLRDEGIYTCAATNLAGESKREVAL------KVLVPPNIEPGPVNKAVLENASV 621
Query: 354 RLSMKVKAFPSPEVVWLKDGLPATE-KSARYLTRGYSLIIKDVTEEDAGNYTILLSIKQS 412
L P P+V W K P + G L I+ DAG+Y + S
Sbjct: 622 TLECLASGVPPPDVSWFKGHQPVSSWMGVTVSVDGRVLRIEQAQLSDAGSYRCVASNVAG 681
Query: 413 NVFKNLTATLIVNVKPQIYEKAVSSFPDPALYPLGSRQILTCTAYGIPQPTIKWFWHPCN 472
+ L L VNV P+I S P P L R LTC A G P PT+ W
Sbjct: 682 ST--ELRYGLRVNVPPRI--TLPPSLPGPVLVNTPVR--LTCNATGAPSPTLMWL----- 730
Query: 473 HNHSEARCDFCSNNEESFILDADSNMGNRIESI-TQRMAIIEGKNKMASTLVVADSRISG 531
GN + T + + G + TL A + SG
Sbjct: 731 ------------------------KDGNPVSPAGTPGLQVFPGGRVL--TLASARASDSG 764
Query: 532 IYICIASNKVGTVGRNISFYITDVPNGFHVNLEKMPTEGEDLKLSCTVNKFLYRDVTWIL 591
Y C+A + VG +++ + P+ L E + L C + ++W
Sbjct: 765 RYSCVAVSAVGEDRQDVVLQVHMPPSILGEELNVSVVANESVALECQSHAMPPPVLSWWK 824
Query: 592 -LRTVNNRT-MHYSISKQKMAITKEHSITLNLTIMNVSLQDSGTYACRARN 640
R + R +H S K + + + + D+G Y C A N
Sbjct: 825 DGRPLEPRPGVHLSADKALLQVDR------------ADVWDAGHYTCEALN 863
Score = 53.1 bits (126), Expect = 8e-07
Identities = 110/506 (21%), Positives = 185/506 (36%), Gaps = 85/506 (16%)
Query: 160 VTSPNITVTLKKFPLDTLIPDGKRIIWD-SRKGFIISNATYKEIGLLTCEATVNGHLYKT 218
V +PNIT F L+P ++++ + + A + G+ TC+A+
Sbjct: 247 VPTPNITW----FKDGALLPTSTKVVYTRGGRQLQLGRAQSSDAGVYTCKAS-------- 294
Query: 219 NYLTHRQTNTIIDVQI--------STPRPVKLLRGHTLVLNCTATTPLNTRVQMTWSYPD 270
N + + T +DV + P VK + G + L C A T S+
Sbjct: 295 NAVGAAEKATRLDVYVPPTIEGAGGRPYVVKAVAGRPVALECVA----RGHPSPTLSWHH 350
Query: 271 EKNKRASVRRRIDQSNSHANIFYSVLTIDKMQNKDKGLYTCRVRSGPSFKSV-NTSVHIY 329
E A + + S SVL ++ GLY+C V S P+ ++V SV +
Sbjct: 351 EGLPVA------ESNESRLETDGSVLRLESPGEASSGLYSC-VASSPAGEAVLQYSVEVQ 403
Query: 330 DKAFITVKHRKQQVLETVAGKRSYRLSMKVKAFPSPEVVWLKDGLPATE-KSARYLTRGY 388
+ V QV T+ G+ L + P P + WL++G PA E + ++G
Sbjct: 404 VPPQLLVAEGLGQVT-TIVGQ-PLELPCQASGSPVPTIQWLQNGRPAEELAGVQVASQGT 461
Query: 389 SLIIKDVTEEDAGNYTILLSIKQSNVFKNLTATLIVNVKPQIYEKAVSSFPDPALYPLGS 448
+L I V + +G L + + +N A + V+V + P P+G
Sbjct: 462 TLHIDHVELDHSG----LFACQATNEAGTAGAEVEVSVHGE-------WAPGVLEVPIG- 509
Query: 449 RQILTCTAYGIPQPTIKWFWHPCNHNHSEARCD-----FCSNNEESFILDADSNMGNRIE 503
++ W +H+ A CD + + +++ + G
Sbjct: 510 ----------------QYHWGXEHHSSFPAACDPPVHRGWGAHPKPPLVEGWCSPG---- 549
Query: 504 SITQRMAIIEGKNKMASTLVV--ADSRISGIYICIASNKVGTVGRNISFYITDVPNGFHV 561
S+ I + L + D R GIY C A+N G R ++ + PN
Sbjct: 550 SLWGEPTGIPVAYSLPPPLQIEKVDLRDEGIYTCAATNLAGESKREVALKVLVPPNIEPG 609
Query: 562 NLEKMPTEGEDLKLSCTVNKFLYRDVTWILLRTVNNRTMHYSISKQKMAITKEHSITLNL 621
+ K E + L C + DV+W + M ++S L
Sbjct: 610 PVNKAVLENASVTLECLASGVPPPDVSWFKGHQPVSSWMGVTVSVDGRV----------L 659
Query: 622 TIMNVSLQDSGTYACRARNVYTGEEI 647
I L D+G+Y C A NV E+
Sbjct: 660 RIEQAQLSDAGSYRCVASNVAGSTEL 685
Score = 52.4 bits (124), Expect = 1e-06
Identities = 92/372 (24%), Positives = 136/372 (36%), Gaps = 63/372 (16%)
Query: 295 VLTIDKMQNKDKGLYTCRVRSGPSFKSVNTSVHIYDKAFITVKHRKQQVLETVAGKRSYR 354
VL I D+G Y C S ++ + + ++ I + +V V +
Sbjct: 182 VLRITGSHVGDEGRYQCVAFSPAGQQARDFQLRVHAPPTIWGSNETGEV--AVMEDHLVQ 239
Query: 355 LSMKVKAFPSPEVVWLKDG-LPATEKSARYLTRGYSLIIKDVTEEDAGNYTILLSIKQSN 413
L + + P+P + W KDG L T Y G L + DAG YT K SN
Sbjct: 240 LLCEARGVPTPNITWFKDGALLPTSTKVVYTRGGRQLQLGRAQSSDAGVYT----CKASN 295
Query: 414 VF--KNLTATLIVNVKPQIYEKAVSSFPDPALYPLGSRQILTCTAYGIPQPTIKWFWHPC 471
L V V P I + P G L C A G P PT+ W
Sbjct: 296 AVGAAEKATRLDVYVPPTI--EGAGGRPYVVKAVAGRPVALECVARGHPSPTLSW----- 348
Query: 472 NHNHSEARCDFCSNNEESFILDADSNMGNRIESITQRMAIIEGKNKMASTLVVADSRISG 531
H E +NE L+ D ++ R+ES SG
Sbjct: 349 ---HHEG-LPVAESNESR--LETDGSV-LRLES--------------------PGEASSG 381
Query: 532 IYICIASNKVGTVGRNISFYITDVPNGFHV--NLEKMPT-EGEDLKLSCTVNKFLYRDVT 588
+Y C+AS+ G S + VP V L ++ T G+ L+L C + +
Sbjct: 382 LYSCVASSPAGEAVLQYSVEV-QVPPQLLVAEGLGQVTTIVGQPLELPCQASGSPVPTIQ 440
Query: 589 WILLRTVNNRTMHYSISKQKMAITKEHSITLNLTIMNVSLQDSGTYACRARNV--YTGEE 646
W+ N R +++A + S L I +V L SG +AC+A N G E
Sbjct: 441 WL----QNGR------PAEELAGVQVASQGTTLHIDHVELDHSGLFACQATNEAGTAGAE 490
Query: 647 ILQKKEITIRGE 658
+ E+++ GE
Sbjct: 491 V----EVSVHGE 498
Score = 52.0 bits (123), Expect = 2e-06
Identities = 86/382 (22%), Positives = 141/382 (36%), Gaps = 45/382 (11%)
Query: 91 TLTLNTAQANHTGFYSCKYLAVPTSKKKETESAIYIFISDTGRPFVEMYSEIPEIIHMTE 150
+L L A +G YSC V S+ E + + + P +E + P + +T
Sbjct: 2175 SLQLEAVGAGDSGTYSC----VAVSEAGEARRHFQLTVMEP--PHIEDSGQ-PTELSLTP 2227
Query: 151 GRELVIPCRVT-SPNITVTLKKFPLDTLIPDGKRIIWDSRKGFIISNATYKEIGLLTCEA 209
G + + C +P +T K DG+ + ++ GL TC A
Sbjct: 2228 GAPMELLCDAQGTPQPNITWHK--------DGQALTRLENNSRATRVLRVRDAGLYTCLA 2279
Query: 210 TVNGHLYKTNYLTHRQTNTIIDVQISTPRPVKLLRGHTLVLNCTATTPLNTRVQMTWSYP 269
+ ++ Q I V PR V L LVL C+ ++ TW
Sbjct: 2280 ESPAGAIEKSFRVRVQAPPNI-VGPRGPRFVVGLAPGQLVLECSVEAEPAPKI--TWH-- 2334
Query: 270 DEKNKRASVRRRIDQSNSHANIFYS--VLTIDKMQNKDKGLYTCRVRSGPSFKSVNTSVH 327
R + + Q ++H L + + D G Y+C R+ SV V
Sbjct: 2335 -----RDGI---VLQEDAHTQFPERGRFLQLQALSTADSGDYSCTARNAAGSTSVAFRVE 2386
Query: 328 IYDKAFITVKHRKQQVLETVAGKRSYRLSMKVKAFPSPEVVWLKDGLPATEKSARY--LT 385
I+ I R V+ ++ L + P+P V W KD +P +S R+ L
Sbjct: 2387 IHTVPTI----RSGPPAVNVSVNQTALLPCQADGVPAPLVSWRKDRVPLDPRSPRFEILP 2442
Query: 386 RGYSLIIKDVTEEDAGNYTILLSIKQSNVFKNLTATLIVNVKPQIYEKAVSSFPDPALYP 445
G SL I+ V +DAG+Y L S + + + + A++ P
Sbjct: 2443 EG-SLRIQPVLAQDAGHYLCLASNSAGSDRQGRDLRV-------LEPPAIAPSPSNLTLT 2494
Query: 446 LGSRQILTCTAYGIPQPTIKWF 467
+ +L C A G P+P + W+
Sbjct: 2495 AHTPALLPCEASGSPKPLVVWW 2516
Score = 47.8 bits (112), Expect = 3e-05
Identities = 50/184 (27%), Positives = 70/184 (38%), Gaps = 14/184 (7%)
Query: 288 HANIFYSVLTIDKMQNKDKGLYTCRV--RSGPSFKSVNTSVHIYDKAFITVKHRKQQVLE 345
H + ++L +D+ D G YTC ++G S K N +V + + H
Sbjct: 836 HLSADKALLQVDRADVWDAGHYTCEALNQAGHSEKHYNLNVWVAPVFPLRESHTL----- 890
Query: 346 TVAGKRSYRLSMKVKAFPSPEVVWLKDGLPATEKSA---RYLTRGYSLIIKDVTEEDAGN 402
TV RLS + + P P++ W KDG P + A G L + G
Sbjct: 891 TVREGHPTRLSCECRGVPFPKISWRKDGQPLPGEGAGLQHVSAVGRLLYLGQAQLAQEGT 950
Query: 403 YTILLSIKQSNVFKNLTATLIVNVKPQIYEKAVSSFPDPALYPLGSRQILTCTAYGIPQP 462
YT S N ++L L V+V PQI P L C A G P P
Sbjct: 951 YTCECSNVVGNSSQDL--QLEVHVPPQI--AGPREPPTQVSVVQDGVATLECNATGKPPP 1006
Query: 463 TIKW 466
T+ W
Sbjct: 1007 TVTW 1010
Score = 44.3 bits (103), Expect = 4e-04
Identities = 80/369 (21%), Positives = 135/369 (36%), Gaps = 76/369 (20%)
Query: 295 VLTIDKMQNKDKGLYTCRVRSGPSFKSVNTSVHIYDKAFIT---VKHRKQQVLETVAGKR 351
VL I ++ ++ G Y+C+ + V Y+ +T + ++++E V
Sbjct: 1523 VLQIPLVRAENAGRYSCKASN-----EVGEDWLHYELLVLTPPVILGDTEELVEEVTVNA 1577
Query: 352 SYRLSMKVKAF--PSPEVVWLKDGLP-ATEKSARYLTRGYSLIIKDVTEEDAGNYTILLS 408
S +S++ A P P + WL++GLP + + L G L + DA +Y +
Sbjct: 1578 SSTVSLQCPALGNPVPTISWLQNGLPFSPSPRLQVLEDGQVLQVSTAEVADAASYMCVAE 1637
Query: 409 IKQSNVFKNLTATLIVNVKPQIYEKAVSSFPDPALYPLGSRQILTCTAYGIPQPTIKWFW 468
+ + K T L V V P+I + + L S L C + P P + W+
Sbjct: 1638 NQAGSAEKLFT--LRVQVPPRIAGLDL----EQVTAILNSSVSLPCDVHAHPNPEVTWY- 1690
Query: 469 HPCNHNHSEARCDFCSNNEESFILDADSNMGNRIESITQRMAIIEGKNKMASTLVVADSR 528
S+A S EE F+L TL + +R
Sbjct: 1691 -----KDSQA----LSLGEEVFLLPG------------------------THTLQLGRAR 1717
Query: 529 IS--GIYICIASNKVGTVGRNISFYITDVPNGFHVNLEKMPTE------GEDLKLSCTVN 580
+S G+Y C A N G + + + VP F + P + G+ LSC +
Sbjct: 1718 LSDSGMYTCEALNAAGRDQKLVQLSVL-VPPAFR-QAPRGPQDAVLVRVGDKAVLSCETD 1775
Query: 581 KFLYRDVTWILLRTVNNRTMHYSISKQKMAITKEHSIT--LNLTIMNVSLQDSGTYACRA 638
VTW Y + + + ++ L I + D G Y+C+
Sbjct: 1776 ALPEPTVTW------------YKDGQPLVLAQRTQALRGGQRLEIQEAQVSDKGLYSCKV 1823
Query: 639 RNVYTGEEI 647
NV GE +
Sbjct: 1824 SNV-AGEAV 1831
Score = 42.0 bits (97), Expect = 0.002
Identities = 42/175 (24%), Positives = 69/175 (39%), Gaps = 15/175 (8%)
Query: 295 VLTIDKMQNKDKGLYTCRVRS--GPSFKSVNTSVHIYDKAFITVKHRKQQVLETVAGKRS 352
VLT+ + D G Y+C S G + V VH+ +++ +V S
Sbjct: 752 VLTLASARASDSGRYSCVAVSAVGEDRQDVVLQVHMPPSIL------GEELNVSVVANES 805
Query: 353 YRLSMKVKAFPSPEVVWLKDGLPATEKSARYLTRGYSLIIKDVTEE-DAGNYTILLSIKQ 411
L + A P P + W KDG P + +L+ +L+ D + DAG+YT +
Sbjct: 806 VALECQSHAMPPPVLSWWKDGRPLEPRPGVHLSADKALLQVDRADVWDAGHYTCEALNQA 865
Query: 412 SNVFKNLTATLIVNVKPQIYEKAVSSFPDPALYPLGSRQILTCTAYGIPQPTIKW 466
+ K+ + V + E + + G L+C G+P P I W
Sbjct: 866 GHSEKHYNLNVWVAPVFPLRESHTLTVRE------GHPTRLSCECRGVPFPKISW 914
Score = 38.5 bits (88), Expect = 0.021
Identities = 30/115 (26%), Positives = 51/115 (44%), Gaps = 10/115 (8%)
Query: 355 LSMKVKAFPSPEVVWLKDGLPAT---EKSARYLTRGYSLIIKDVTEEDAGNYTILLSIKQ 411
L + P P VVW KDG ++ A L +L++ +D+ + ++S +
Sbjct: 2501 LPCEASGSPKPLVVWWKDGQKLDFRLQQGAYRLLPSNALLLTAPGPQDSAQFECVVSNEV 2560
Query: 412 SNVFKNLTATLIVNVKPQIYEKAVSSFPDPALYPLGSRQILTCTAYGIPQPTIKW 466
+ T V+V P I + + F + P+ +LTC + GIP PT+ W
Sbjct: 2561 GEAHRLYQVT--VHVPPTIADDQ-TDFTVTMMAPV----VLTCHSTGIPAPTVSW 2608
Score = 37.7 bits (86), Expect = 0.036
Identities = 40/178 (22%), Positives = 69/178 (38%), Gaps = 17/178 (9%)
Query: 295 VLTIDKMQNKDKGLYTCRVRSGPSFKSVNTSVHIYDKAFITVKHRKQQVLETVAGKRSYR 354
VL I++ Q D G Y C + + + + IT+ + V R
Sbjct: 658 VLRIEQAQLSDAGSYRCVASNVAGSTELRYGLRVNVPPRITLP---PSLPGPVLVNTPVR 714
Query: 355 LSMKVKAFPSPEVVWLKDG---LPATEKSARYLTRGYSLIIKDVTEEDAGNYTILLSIKQ 411
L+ PSP ++WLKDG PA + G L + D+G Y+ +
Sbjct: 715 LTCNATGAPSPTLMWLKDGNPVSPAGTPGLQVFPGGRVLTLASARASDSGRYSCVAVSAV 774
Query: 412 SNVFKNLTATLIVNVKPQIY--EKAVSSFPDPALYPLGSRQILTCTAYGIPQPTIKWF 467
+++ L V++ P I E VS + ++ L C ++ +P P + W+
Sbjct: 775 GEDRQDV--VLQVHMPPSILGEELNVSVVANESV-------ALECQSHAMPPPVLSWW 823
Score = 37.0 bits (84), Expect = 0.061
Identities = 33/132 (25%), Positives = 49/132 (37%), Gaps = 21/132 (15%)
Query: 351 RSYRLSMKVKAFPSPEVVWLKD----GLP------------ATEKSARYLTRGYSLIIKD 394
+S L FP PE+VWLKD G+P R L G SL
Sbjct: 34 QSLTLECDANGFPVPEIVWLKDAQLVGVPLGWAGYGWDLGWGQVGGHRLLDEGQSLHFPR 93
Query: 395 VTEEDAGNYTILLSIKQSNVFKNLTATLIVNVKPQIYEKAVSSFPDPALYPLGSRQILTC 454
+ E D+G Y+ + ++ L+V P + + L G+ L C
Sbjct: 94 IQEGDSGLYSCRAENQAGTAQRDF--HLLVLTPPSVLGAGAA---QEVLGLAGADVELQC 148
Query: 455 TAYGIPQPTIKW 466
G+P P ++W
Sbjct: 149 WTSGVPTPQVEW 160
Score = 37.0 bits (84), Expect = 0.061
Identities = 90/417 (21%), Positives = 144/417 (34%), Gaps = 69/417 (16%)
Query: 77 TKSACGRNGKQFCSTLTLNTAQANHTGFYSCKYLAVPTSKKKETESAIYIFISDTGRPFV 136
TK R G+Q L L AQ++ G Y+CK + +K T +Y+ P +
Sbjct: 265 TKVVYTRGGRQ----LQLGRAQSSDAGVYTCKASNAVGAAEKATRLDVYV------PPTI 314
Query: 137 EMYSEIPEIIHMTEGRELVIPCRVTS-PNITVTLKKFPLDTLIPDGKRIIWDSRKGFIIS 195
E P ++ GR + + C P+ T++ L + R+ D +
Sbjct: 315 EGAGGRPYVVKAVAGRPVALECVARGHPSPTLSWHHEGLPVAESNESRLETDG-SVLRLE 373
Query: 196 NATYKEIGLLTCEATVNGHLYKTNYLTHRQTNTIIDVQISTPRPVKLLRGHTLVLNCTAT 255
+ GL +C A+ Y Q + V + V + G L L C A+
Sbjct: 374 SPGEASSGLYSCVASSPAGEAVLQYSVEVQVPPQLLVAEGLGQ-VTTIVGQPLELPCQAS 432
Query: 256 -TPLNTRVQMTWSYPDEKNKRASVRRRIDQSNSHANIFYSVLTIDKMQNKDKGLYTCRV- 313
+P+ T + P E+ V + + L ID ++ GL+ C+
Sbjct: 433 GSPVPTIQWLQNGRPAEELAGVQVASQ-----------GTTLHIDHVELDHSGLFACQAT 481
Query: 314 -RSGPSFKSVNTSVHIYDKAFITVKHRKQQVLETVAGKRSYRLSMKVK------------ 360
+G + V SVH VLE G+ +
Sbjct: 482 NEAGTAGAEVEVSVH---------GEWAPGVLEVPIGQYHWGXEHHSSFPAACDPPVHRG 532
Query: 361 --AFPSPEVV--WLKDGLPATEKSARYLTRGYS----LIIKDVTEEDAGNYTILLSIKQS 412
A P P +V W G E + + YS L I+ V D G YT +
Sbjct: 533 WGAHPKPPLVEGWCSPGSLWGEPTG--IPVAYSLPPPLQIEKVDLRDEGIYTCAATNLAG 590
Query: 413 NVFKNLTATLIV--NVKPQIYEKAVSSFPDPALYPLGSRQILTCTAYGIPQPTIKWF 467
+ + ++V N++P KAV + L C A G+P P + WF
Sbjct: 591 ESKREVALKVLVPPNIEPGPVNKAVLE---------NASVTLECLASGVPPPDVSWF 638
Score = 35.0 bits (79), Expect = 0.23
Identities = 42/174 (24%), Positives = 65/174 (37%), Gaps = 9/174 (5%)
Query: 296 LTIDKMQNKDKGLYTCRVRSGPSFKSVNTSVHIYDKAFITVKHRKQQVLETVAGKRSYRL 355
L ++Q D GLY+CR + + + + + Q+VL +AG L
Sbjct: 89 LHFPRIQEGDSGLYSCRAENQAGTAQRDFHLLVLTPPSVLGAGAAQEVL-GLAG-ADVEL 146
Query: 356 SMKVKAFPSPEVVWLKDGLPATEKSARYLTR--GYSLIIKDVTEEDAGNYTILLSIKQSN 413
P+P+V W KD P + G L I D G Y +
Sbjct: 147 QCWTSGVPTPQVEWTKDRQPVLPGGPHLQVQEDGQVLRITGSHVGDEGRYQCVAFSPAGQ 206
Query: 414 VFKNLTATLIVNVKPQIYEKAVSSFPDPALYPLGSRQILTCTAYGIPQPTIKWF 467
++ L V+ P I+ + + A+ Q+L C A G+P P I WF
Sbjct: 207 QARDF--QLRVHAPPTIW--GSNETGEVAVMEDHLVQLL-CEARGVPTPNITWF 255
Score = 31.2 bits (69), Expect = 3.3
Identities = 18/62 (29%), Positives = 27/62 (43%), Gaps = 2/62 (3%)
Query: 530 SGIYICIASNKVGTVGRNISFYITDVPN--GFHVNLEKMPTEGEDLKLSCTVNKFLYRDV 587
SG+Y C A N+ GT R+ + P+ G E + G D++L C + V
Sbjct: 99 SGLYSCRAENQAGTAQRDFHLLVLTPPSVLGAGAAQEVLGLAGADVELQCWTSGVPTPQV 158
Query: 588 TW 589
W
Sbjct: 159 EW 160
Score = 30.4 bits (67), Expect = 5.7
Identities = 34/137 (24%), Positives = 54/137 (39%), Gaps = 12/137 (8%)
Query: 296 LTIDKMQNKDKGLYTCRVRSGPSFKSVNTSVHIYDKAFITVKHRKQQVLETVAGKRSYRL 355
LTI + + D G Y C + + + V+ + TV L
Sbjct: 2991 LTIRRTERDDAGRYQCLAENEMGVAKKVVILVLQSAPVFQVEPQDM----TVRSGDDVAL 3046
Query: 356 SMKVKAFPSPEVVWLKDGLP-ATEKSARYLTRGYSLIIKDVTEEDAGNYTILLSIKQSNV 414
+ P+P + WL+ G P + R L G SL +++V DAG Y + N+
Sbjct: 3047 RCQATGEPTPTIEWLQAGQPLRASRRLRTLPDG-SLWLENVETGDAGTYDCV----AHNL 3101
Query: 415 FKNLTAT--LIVNVKPQ 429
+ TA L+V +PQ
Sbjct: 3102 LGSATARAFLVVRGEPQ 3118
>gi|38490688 immunoglobulin superfamily, member 10 [Homo sapiens]
Length = 2623
Score = 72.0 bits (175), Expect = 2e-12
Identities = 140/656 (21%), Positives = 255/656 (38%), Gaps = 115/656 (17%)
Query: 32 PELSLKGTQHI-MQAGQTLHLQCRGEAAHKWSLPEMVSKESERLSITKSACGRNGKQFC- 89
P + + T+ I + +G T+ L+CR E ++ +++ ++ +++S+ G
Sbjct: 1745 PRILERRTKEITVHSGSTVELKCRAEGRPSPTVTWILANQTV---VSESSQGSRQAVVTV 1801
Query: 90 -STLTLNTAQANHTGFYSCKYLAVPTSKKKETESAIYIFISDTGRPFVEMYSEIPEIIHM 148
TL L+ GFY C + + ++ + I P V + + ++I
Sbjct: 1802 DGTLVLHNLSIYDRGFYKC------VASNPGGQDSLLVKIQVIAAPPV-ILEQRRQVIVG 1854
Query: 149 TEGRELVIPCRVTSPNITVTLKKFPLDTL---IPDG---KRIIWDSRKGFIISNATY--- 199
T G L +PC T K P ++ + DG K + + + K F+ SN T
Sbjct: 1855 TWGESLKLPC---------TAKGTPQPSVYWVLSDGTEVKPLQFTNSKLFLFSNGTLYIR 1905
Query: 200 ----KEIGLLTCEATVN-GHLYKTNYLTHRQTNTIIDVQISTPRPVKLLRGHTLVLNCTA 254
+ G C AT + G + LT + T ++ ++ + ++ G L+LNC+A
Sbjct: 1906 NLASSDRGTYECIATSSTGSERRVVMLTMEERVTSPRIEAASQKRTEVNFGDKLLLNCSA 1965
Query: 255 TTPLNTRVQMTWSYPDEKNKRASVRRRIDQSNSHANIFYS-VLTIDKMQNKDKGLYTCRV 313
T + Q+ W P + +V + + S +++ + L I + KD G+Y C
Sbjct: 1966 TG--EPKPQIMWRLPSK-----AVVDQQHRVGSWIHVYPNGSLFIGSVTEKDSGVYLCVA 2018
Query: 314 RS--GPSFKSVNTSVHIYDKAFITVKHRKQQVLETVAGKRSYRLSMKVKAFPSPEVVW-L 370
R+ G ++ S+ + ++ ++QVL + +++ K P PE+ W L
Sbjct: 2019 RNKMGDDLILMHVSLRLKPAKIDHKQYFRKQVLHG----KDFQVDCKASGSPVPEISWSL 2074
Query: 371 KDGLPATEK----SARYLTRGYSLI------IKDVTEEDAGNYTILL--SIKQSNVFKNL 418
DG + + TR Y+L V + G+YT ++ + + +L
Sbjct: 2075 PDGTMINNAMQADDSGHRTRRYTLFNNGTLYFNKVGVAEEGDYTCYAQNTLGKDEMKVHL 2134
Query: 419 TATLIVNVKPQIYEKAVSSFPDPALYPLGSRQILTCTAYGIPQPTIKWFWHPCNHNHSEA 478
T ++ P+I + ++ A G +L C G P+P I W
Sbjct: 2135 T---VITAAPRIRQSNKTNKRIKA----GDTAVLDCEVTGDPKPKIFWL----------- 2176
Query: 479 RCDFCSNNEESFILDADSNMGNRIESITQRMAIIEGKNKMASTLVVADSRISGIYICIAS 538
SN+ SF +D + N +I K K+ SG Y+C+A
Sbjct: 2177 ---LPSNDMISFSIDRYTFHANGSLTIN--------KVKLLD---------SGEYVCVAR 2216
Query: 539 NKVGTVGRNISFYITDVP---NGFHVN---LEKMPTEGEDLKLSCTVNKFLYRDVTWILL 592
N G + + P NG + N ++ C +V WI+
Sbjct: 2217 NPSGDDTKMYKLDVVSKPPLINGLYTNRTVIKATAVRHSKKHFDCRAEGTPSPEVMWIMP 2276
Query: 593 RTVNNRTMHYSISKQKMAITKEHSITLNLTIMNVSLQDSGTYACRARNVYTGEEIL 648
+ +Y ++ + K + L I NV L DS + C ARN GE +L
Sbjct: 2277 DNIFLTAPYYG---SRITVHKNGT----LEIRNVRLSDSADFICVARN-EGGESVL 2324
Score = 57.4 bits (137), Expect = 4e-08
Identities = 135/631 (21%), Positives = 229/631 (36%), Gaps = 112/631 (17%)
Query: 46 GQTLHLQCRGEAAHK----WSLPEMVSKESERLSITKSACGRNGKQFCSTLTLNTAQANH 101
G L L C K W LP + + + NG F ++T
Sbjct: 1956 GDKLLLNCSATGEPKPQIMWRLPSKAVVDQQHRVGSWIHVYPNGSLFIGSVT-----EKD 2010
Query: 102 TGFYSCKYLAVPTSKKKETESAIYIFISDTGRPFVEMYSEI--PEIIHMTEGRELVIPCR 159
+G Y C ++ K + I + +S +P + + +++H G++ + C+
Sbjct: 2011 SGVYLC------VARNKMGDDLILMHVSLRLKPAKIDHKQYFRKQVLH---GKDFQVDCK 2061
Query: 160 VTSPNITVTLKKFPLDTLIPDGKRIIWD---SRKGFIISNAT--YKEIGLL-----TCEA 209
+ + P T+I + + +R+ + +N T + ++G+ TC A
Sbjct: 2062 ASGSPVPEISWSLPDGTMINNAMQADDSGHRTRRYTLFNNGTLYFNKVGVAEEGDYTCYA 2121
Query: 210 TVNGHLYKTNYLTHRQTNTIID-VQISTPRPVKLLRGHTLVLNCTATTPLNTRVQMTWSY 268
L K H T ++ S ++ G T VL+C T + + ++ W
Sbjct: 2122 --QNTLGKDEMKVHLTVITAAPRIRQSNKTNKRIKAGDTAVLDCEVTG--DPKPKIFWLL 2177
Query: 269 PDEKNKRASVRRRIDQSNSHANIFYSVLTIDKMQNKDKGLYTCRVR--SGPSFKSVNTSV 326
P + ID+ HAN LTI+K++ D G Y C R SG K V
Sbjct: 2178 PSND----MISFSIDRYTFHAN---GSLTINKVKLLDSGEYVCVARNPSGDDTKMYKLDV 2230
Query: 327 HIYDKAFITVKHRKQQVLETVAGKRSYR-LSMKVKAFPSPEVVWLKDG---LPATEKSAR 382
+ I + + V++ A + S + + + PSPEV+W+ L A +R
Sbjct: 2231 -VSKPPLINGLYTNRTVIKATAVRHSKKHFDCRAEGTPSPEVMWIMPDNIFLTAPYYGSR 2289
Query: 383 YLT-RGYSLIIKDVTEEDAGNYTILLSIKQSNVFKNLTATLIVNVKPQIYEKAV-----S 436
+ +L I++V D+ ++ V +N ++ V+ ++ E +
Sbjct: 2290 ITVHKNGTLEIRNVRLSDSADFIC--------VARNEGGESVLVVQLEVLEMLRRPTFRN 2341
Query: 437 SFPDPALYPLGSRQILTCTAYGIPQPTIKWFWHPCNHNHSEARCDFCSNNEESFILDADS 496
F + + LG L C+ G P P I W SN +S+ S
Sbjct: 2342 PFNEKIVAQLGKSTALNCSVDGNPPPEIIWILPNGTR---------FSNGPQSYQYLIAS 2392
Query: 497 NMGNRIESITQRMAIIEGKNKMASTLVVADSRISGIYICIASNKVGTVGRNISFYITDVP 556
N G+ I S T R +G Y C A NKVG + + + I P
Sbjct: 2393 N-GSFIISKTTR-------------------EDAGKYRCAARNKVGYIEKLVILEIGQKP 2432
Query: 557 NGFHVNLEKMP-----TEGEDLKLSCTVNKFLYRDVTWILLRTVNNRTMHYSISKQKMAI 611
V L P GE L L C + ++ W TM + I
Sbjct: 2433 ----VILTYAPGTVKGISGESLSLHCVSDGIPKPNIKW---------TMPSGYVVDRPQI 2479
Query: 612 TKEHSITLN--LTIMNVSLQDSGTYACRARN 640
++ + N L I + D G Y C+A+N
Sbjct: 2480 NGKYILHDNGTLVIKEATAYDRGNYICKAQN 2510
Score = 54.7 bits (130), Expect = 3e-07
Identities = 70/296 (23%), Positives = 104/296 (35%), Gaps = 45/296 (15%)
Query: 351 RSYRLSMKVKAFPSPEVVW-LKDGLPATEKSARY---LTRGYSLIIKDVTEEDAGNYTIL 406
+S L+ V P PE++W L +G + Y + S II T EDAG Y
Sbjct: 2353 KSTALNCSVDGNPPPEIIWILPNGTRFSNGPQSYQYLIASNGSFIISKTTREDAGKYRCA 2412
Query: 407 LSIKQSNVFKNLTATLIVNVKPQIYEKAVSSFPDPALYPLGSRQILTCTAYGIPQPTIKW 466
K + K L + KP I A P G L C + GIP+P IKW
Sbjct: 2413 ARNKVGYIEK--LVILEIGQKPVILTYA----PGTVKGISGESLSLHCVSDGIPKPNIKW 2466
Query: 467 FWHPCNHNHSEARCDFCSNNEESFILDADSNMGNRIESITQRMAIIEGKNKMASTLVVAD 526
+++D G I + I E A
Sbjct: 2467 ------------------TMPSGYVVDRPQINGKYILHDNGTLVIKE-----------AT 2497
Query: 527 SRISGIYICIASNKVGTVGRNISFYITDVPNGFHVNLEK--MPTEGEDLKLSCTVNKFLY 584
+ G YIC A N VG + I P + + G +L C
Sbjct: 2498 AYDRGNYICKAQNSVGHTLITVPVMIVAYPPRITNRPPRSIVTRTGAAFQLHCVALGVPK 2557
Query: 585 RDVTWILLRTVNNRTMHYSISKQKMAITKEHSITLNLTIMNVSLQDSGTYACRARN 640
++TW + + ++ + SK++ +++ + L I N DSG Y C A+N
Sbjct: 2558 PEITW----EMPDHSLLSTASKERTHGSEQLHLQGTLVIQNPQTSDSGIYKCTAKN 2609
Score = 52.4 bits (124), Expect = 1e-06
Identities = 122/567 (21%), Positives = 206/567 (36%), Gaps = 87/567 (15%)
Query: 146 IHMTEGRELVIPCRVT---SPNITVTLKKFPLDTLIPDGKRIIWDSRKG-FIISNATYKE 201
I + G + + CR SP +T L + + G R + G ++ N + +
Sbjct: 1755 ITVHSGSTVELKCRAEGRPSPTVTWILANQTVVSESSQGSRQAVVTVDGTLVLHNLSIYD 1814
Query: 202 IGLLTCEATVNGHLYKTNYLTHRQTNTIIDVQISTPRPVKLLR---------GHTLVLNC 252
G C A+ G Q + ++ +Q+ PV L + G +L L C
Sbjct: 1815 RGFYKCVASNPGG----------QDSLLVKIQVIAAPPVILEQRRQVIVGTWGESLKLPC 1864
Query: 253 TAT-TPLNTRVQMTWSYPDEKNKRASVRRRIDQSNSHANIFYS-VLTIDKMQNKDKGLYT 310
TA TP + + W D + + +NS +F + L I + + D+G Y
Sbjct: 1865 TAKGTP---QPSVYWVLSDGTEVKP-----LQFTNSKLFLFSNGTLYIRNLASSDRGTYE 1916
Query: 311 CRVRSGPSFKSVNTSVHIYDKAFIT---VKHRKQQVLETVAGKRSYRLSMKVKAFPSPEV 367
C S S S V + + +T ++ Q+ E G + L+ P P++
Sbjct: 1917 CIATS--STGSERRVVMLTMEERVTSPRIEAASQKRTEVNFGDKLL-LNCSATGEPKPQI 1973
Query: 368 VWLKDGLPATEKSAR-----YLTRGYSLIIKDVTEEDAGNYTILLSIKQSNVFKNLTATL 422
+W ++ R ++ SL I VTE+D+G Y + K + + +L
Sbjct: 1974 MWRLPSKAVVDQQHRVGSWIHVYPNGSLFIGSVTEKDSGVYLCVARNKMGDDLILMHVSL 2033
Query: 423 IVNVKPQIYEKAVSSFPDPALYPLGSRQILTCTAYGIPQPTIKWFWHPCNHNHSEARCDF 482
+KP + F L+ G + C A G P P I W ++ + D
Sbjct: 2034 --RLKPAKIDHK-QYFRKQVLH--GKDFQVDCKASGSPVPEISWSLPDGTMINNAMQAD- 2087
Query: 483 CSNNEESFILDADSNMGNRIESITQRMAIIEGKNKMASTLVVADSRISGIYICIASNKVG 542
+ G+R T+R + + + VA+ G Y C A N +G
Sbjct: 2088 --------------DSGHR----TRRYTLFNNGTLYFNKVGVAEE---GDYTCYAQNTLG 2126
Query: 543 TVGRNISF-YITDVPNGFHVN-LEKMPTEGEDLKLSCTVNKFLYRDVTWILLRTVNNRTM 600
+ IT P N K G+ L C V + W+L +N +
Sbjct: 2127 KDEMKVHLTVITAAPRIRQSNKTNKRIKAGDTAVLDCEVTGDPKPKIFWLL---PSNDMI 2183
Query: 601 HYSISKQKMAITKEHSITLNLTIMNVSLQDSGTYACRARNVYTGEEILQKKEIT-----I 655
+SI + +LTI V L DSG Y C ARN + + K ++ I
Sbjct: 2184 SFSIDRYTFHANG------SLTINKVKLLDSGEYVCVARNPSGDDTKMYKLDVVSKPPLI 2237
Query: 656 RGEHCNKKAVFSRISKFKSTRNDCTTQ 682
G + N+ + + + DC +
Sbjct: 2238 NGLYTNRTVIKATAVRHSKKHFDCRAE 2264
Score = 48.1 bits (113), Expect = 3e-05
Identities = 56/229 (24%), Positives = 82/229 (35%), Gaps = 40/229 (17%)
Query: 427 KPQIYEKAVSSFPDPALYPLGSRQILTCTAYGIPQPTIKWFWHPCNHNHSEARCDFCSNN 486
KP+I +SF PA S L C A G P PTI W P
Sbjct: 1647 KPRIVGGKAASFTIPA----NSDAFLPCEAVGNPLPTIHWTRVPSG-------------- 1688
Query: 487 EESFILDADSNMGNRIESITQRMAIIEGKNKMASTLVVADSRISGIYICIASNKVGTVGR 546
LD N R+ ++ + + D G Y+C ASN GT
Sbjct: 1689 -----LDLSKRKQN------SRVQVLPNGTLSIQRVEIQDR---GQYLCSASNLFGTDHL 1734
Query: 547 NISFYITDVPNGFHVNLEKMPT--EGEDLKLSCTVNKFLYRDVTWILLRTVNNRTMHYSI 604
+++ + P K T G ++L C VTWIL N + S
Sbjct: 1735 HVTLSVVSYPPRILERRTKEITVHSGSTVELKCRAEGRPSPTVTWIL---ANQTVVSESS 1791
Query: 605 SKQKMAITKEHSITLNLTIMNVSLQDSGTYACRARNVYTGEEILQKKEI 653
+ A+ ++ L + N+S+ D G Y C A N + +L K ++
Sbjct: 1792 QGSRQAVV---TVDGTLVLHNLSIYDRGFYKCVASNPGGQDSLLVKIQV 1837
Score = 40.4 bits (93), Expect = 0.006
Identities = 56/254 (22%), Positives = 94/254 (37%), Gaps = 46/254 (18%)
Query: 298 IDKMQNKDKGLYTCRVRSGPSFKSVNTSVHIYDKAFITVKHRKQQVLETVAGKRSYRLSM 357
I K +D G Y C R+ + + I K I ++ ++G+ S L
Sbjct: 2398 ISKTTREDAGKYRCAARNKVGYIEKLVILEIGQKPVILTY--APGTVKGISGE-SLSLHC 2454
Query: 358 KVKAFPSPEVVWLKDGLPATEK---SARYLTRGY-SLIIKDVTEEDAGNYTILLSIKQSN 413
P P + W ++ + +Y+ +L+IK+ T D GNY + Q++
Sbjct: 2455 VSDGIPKPNIKWTMPSGYVVDRPQINGKYILHDNGTLVIKEATAYDRGNY---ICKAQNS 2511
Query: 414 VFKNLTAT--LIVNVKPQIYEKAVSSFPDPALYPLGSRQILTCTAYGIPQPTIKWFWHPC 471
V L +IV P+I + P + G+ L C A G+P+P I W
Sbjct: 2512 VGHTLITVPVMIVAYPPRITNRP----PRSIVTRTGAAFQLHCVALGVPKPEITW----- 2562
Query: 472 NHNHSEARCDFCSNNEESFILDADSNMGNRIESITQRMAIIEGKNKMASTLVVADSRI-- 529
+ S + A + E + + TLV+ + +
Sbjct: 2563 ------------EMPDHSLLSTASKERTHGSEQL-----------HLQGTLVIQNPQTSD 2599
Query: 530 SGIYICIASNKVGT 543
SGIY C A N +G+
Sbjct: 2600 SGIYKCTAKNPLGS 2613
Score = 35.0 bits (79), Expect = 0.23
Identities = 49/233 (21%), Positives = 87/233 (37%), Gaps = 20/233 (8%)
Query: 179 PDGKRIIWDSRKGFIISNATYKEIGLLTCEATVN-GHLYKTNYLTHRQTNTIIDVQISTP 237
P + + S FIIS T ++ G C A G++ K L Q I+ P
Sbjct: 2383 PQSYQYLIASNGSFIISKTTREDAGKYRCAARNKVGYIEKLVILEIGQKPVILTY---AP 2439
Query: 238 RPVKLLRGHTLVLNCTATTPLNTRVQMTWSYPDEKNKRASVRRRIDQSNSHANIFYSVLT 297
VK + G +L L+C + ++ W+ P V R + + L
Sbjct: 2440 GTVKGISGESLSLHCVSDGIPKPNIK--WTMPS-----GYVVDRPQINGKYILHDNGTLV 2492
Query: 298 IDKMQNKDKGLYTCRVRSGPSFKSVNTSVHIYDKAFITVKHRKQQVLETVAGKRSYRLSM 357
I + D+G Y C+ ++ + V I + +R + + T G +++L
Sbjct: 2493 IKEATAYDRGNYICKAQNSVGHTLITVPVMIVAYP-PRITNRPPRSIVTRTG-AAFQLHC 2550
Query: 358 KVKAFPSPEVVWLKDGLPATEKSARYLTRGY-------SLIIKDVTEEDAGNY 403
P PE+ W +++ T G +L+I++ D+G Y
Sbjct: 2551 VALGVPKPEITWEMPDHSLLSTASKERTHGSEQLHLQGTLVIQNPQTSDSGIY 2603
Score = 34.7 bits (78), Expect = 0.30
Identities = 51/218 (23%), Positives = 81/218 (37%), Gaps = 26/218 (11%)
Query: 108 KYLAVPTSKKKETESAIYIFISDTGRPFVEMYSEIPEIIHMTEGRELVIPC---RVTSPN 164
KY +K E + + I +P + Y+ P + G L + C + PN
Sbjct: 2408 KYRCAARNKVGYIEKLVILEIGQ--KPVILTYA--PGTVKGISGESLSLHCVSDGIPKPN 2463
Query: 165 ITVTLKK-FPLDTLIPDGKRIIWDSRKGFIISNATYKEIGLLTCEATVN-GHLYKTNYLT 222
I T+ + +D +GK I+ D+ +I AT + G C+A + GH T +
Sbjct: 2464 IKWTMPSGYVVDRPQINGKYILHDNGT-LVIKEATAYDRGNYICKAQNSVGHTLITVPVM 2522
Query: 223 -----HRQTNTIIDVQISTPRPVKLLRGHTLVLNCTATTPLNTRVQMTWSYPDEKNKRAS 277
R TN PR + G L+C A + ++TW PD +
Sbjct: 2523 IVAYPPRITNR-------PPRSIVTRTGAAFQLHCVALGV--PKPEITWEMPDHSLLSTA 2573
Query: 278 VRRRIDQSNSHANIFYSVLTIDKMQNKDKGLYTCRVRS 315
+ R S L I Q D G+Y C ++
Sbjct: 2574 SKERTHGSEQLH--LQGTLVIQNPQTSDSGIYKCTAKN 2609
Score = 34.3 bits (77), Expect = 0.39
Identities = 34/146 (23%), Positives = 60/146 (41%), Gaps = 25/146 (17%)
Query: 522 LVVADSRISGIYICIASN---------KVGTVGRNISFYITDVPNGFHVNLEKMPTEGED 572
L +ADS +G+Y CI+SN ++ V + Y NG H + GE
Sbjct: 538 LQMADSFDTGVYHCISSNYDDADILTYRITVVEPLVEAY---QENGIHHTV----FIGET 590
Query: 573 LKLSCTVNKFLYRDVTWILLRTVNNRTMHYSISKQKMAITKEHSITLNLTIMNVSLQDSG 632
L L C ++W+ + + Y S+ K + L I+ V+ +D G
Sbjct: 591 LDLPCHSTGIPDASISWV----IPGNNVLYQSSRDKKVLNNG-----TLRILQVTPKDQG 641
Query: 633 TYACRARNVYTGEEILQKKEITIRGE 658
Y C A N + ++ + + ++G+
Sbjct: 642 YYRCVAANPSGVDFLIFQVSVKMKGQ 667
>gi|169178458 PREDICTED: hemicentin 2 [Homo sapiens]
Length = 3874
Score = 71.6 bits (174), Expect = 2e-12
Identities = 84/324 (25%), Positives = 125/324 (38%), Gaps = 37/324 (11%)
Query: 149 TEGRELVIPCRVT-SPNITVTLKKFPLDTLIPDGKRIIWDSRKGFIISNATYKEIGLLTC 207
TEG +PC+ SP +T K +GK I S + ++ N ++ G TC
Sbjct: 2859 TEGSHAFLPCKARGSPEPNITWDKDGQPVSGAEGKFTIQPSGE-LLVKNLEGQDAGTYTC 2917
Query: 208 EA-TVNGHLYKTNYLTHRQTNTIIDVQISTPRPVKLLRGHTLVLNCTATTPLNTRVQMTW 266
A G + +LT ++ V + P L G L L C A R+ T
Sbjct: 2918 TAENAVGRARRRVHLTI----LVLPVFTTLPGDRSLRLGDRLWLRCAARGSPTPRIGWT- 2972
Query: 267 SYPDEKNKRASVRRRIDQSNSHANIFYSVLTIDKMQNKDKGLYTCRVRSGPSFKSVNTSV 326
N R +Q S L + +D G Y C + + V
Sbjct: 2973 -----VNDRPVTEGVSEQDGG------STLQRAAVSREDSGTYVCWAENRVGRTQAVSFV 3021
Query: 327 HIYDKAFITVKHRKQQVLETVAGKRSYRLSMKVKAFPSPEVVWLKDGLPATEKSARYLTR 386
H+ + A + ++E V G S +L V+ P P++ W+KDGLP R+ +
Sbjct: 3022 HVKE-APVLQGEAFSYLVEPVGG--SIQLDCVVRGDPVPDIHWIKDGLPLRGSHLRHQLQ 3078
Query: 387 GYSLIIKDVTEEDAGNYTIL----LSIKQSNVFKNLTATLIVNVKPQIYEKAVSSFPDPA 442
SL I +DAG Y L + + + V L + + V+PQ + V S D A
Sbjct: 3079 NGSLTIHRTERDDAGRYQCLAENEMGVAKKVVILVLQSAPVFQVEPQ--DMTVRSGDDVA 3136
Query: 443 LYPLGSRQILTCTAYGIPQPTIKW 466
L C A G P PTI+W
Sbjct: 3137 ---------LRCQATGEPTPTIEW 3151
Score = 70.5 bits (171), Expect = 5e-12
Identities = 83/339 (24%), Positives = 125/339 (36%), Gaps = 65/339 (19%)
Query: 307 GLYTCRVRSGPSFKSVNTSVHIYDKAFITVKHRK-----QQVLETVAGKRSYRLSMKVKA 361
G YTC R N++ + F+TV+ V+ VA + L +
Sbjct: 2732 GRYTCSAR--------NSAGVAHKHVFLTVQASPVVKPLPSVVRAVA-EEEVLLPCEASG 2782
Query: 362 FPSPEVVWLKDGLPATEKSARYLTRGYSLIIKDVTEEDAGNYTILLSIKQSNVFKNLTAT 421
P P + W K+GL + + G L I + EDAGNY L I +++ + T
Sbjct: 2783 IPRPTITWQKEGLNVATGVSTQVLPGGQLRIAHASPEDAGNY---LCIAKNSAGSAMGKT 2839
Query: 422 LIVNVKPQIYEKAVSSFPDPALYPLGSRQILTCTAYGIPQPTIKWFWHPCNHNHSEARCD 481
+V P + E + PD + GS L C A G P+P I W
Sbjct: 2840 RLVVQVPPVIE---NGLPDLSTTE-GSHAFLPCKARGSPEPNITW--------------- 2880
Query: 482 FCSNNEESFILDADSNMGNRIESITQRMAIIEGKNKMASTLVVADSRISGIYICIASNKV 541
D D G + + I + L + + +G Y C A N V
Sbjct: 2881 -----------DKD---GQPVSGAEGKFTIQPSGELLVKNL---EGQDAGTYTCTAENAV 2923
Query: 542 GTVGRNISFYITDVPNGFHVNLEKMPTEGEDLKLSCTVNKFLYRDVTWILLRTVNNRTMH 601
G R + I +P + ++ G+ L L C + W TVN+R +
Sbjct: 2924 GRARRRVHLTILVLPVFTTLPGDRSLRLGDRLWLRCAARGSPTPRIGW----TVNDRPVT 2979
Query: 602 YSISKQKMAITKEHSITLNLTIMNVSLQDSGTYACRARN 640
+S+Q T + + VS +DSGTY C A N
Sbjct: 2980 EGVSEQDGGSTLQRAA--------VSREDSGTYVCWAEN 3010
Score = 65.5 bits (158), Expect = 2e-10
Identities = 84/352 (23%), Positives = 124/352 (35%), Gaps = 57/352 (16%)
Query: 296 LTIDKMQNKDKGLYTCRV--RSGPSFKSVNTSVHIYDKAFITVKHRKQQVLETVAGKRSY 353
L + + + D G+YTC +G K V SV + AF Q + G ++
Sbjct: 1802 LQLGRARLSDSGMYTCEALNAAGRDQKLVQLSV-LVPPAFRQAPRGPQDAVLVRVGDKAV 1860
Query: 354 RLSMKVKAFPSPEVVWLKDGLPAT-EKSARYLTRGYSLIIKDVTEEDAGNYTILLSIKQS 412
LS + A P P V W KDG P + + L G L I++ D G Y S K S
Sbjct: 1861 -LSCETDALPEPTVTWYKDGQPLVLAQRTQALRGGQRLEIQEAQVSDKGLY----SCKVS 1915
Query: 413 NVFKNL--TATLIVNVKPQIYEKAVSSFPDPALYPLGSRQILTCTAYGIPQPTIKWFWHP 470
NV T TL V V P + A GS +LTC G+P PT+ W
Sbjct: 1916 NVAGEAVRTFTLTVQVPPTFENPKTETVSQVA----GSPLVLTCDVSGVPAPTVTWL--- 1968
Query: 471 CNHNHSEARCDFCSNNEESFILDADSNMGNRIESITQRMAIIEGKNKMASTLVVADSRIS 530
+ES + G S L A +
Sbjct: 1969 --------------------------KDRMPVESSAVHGVVSRGGRLQLSRLQPAQ---A 1999
Query: 531 GIYICIASNKVGTVGRNISFYITDVP--NGFHVNLEKMPTEGEDLKLSCTVNKFLYRDVT 588
G Y C+A N ++ + P V E EG++++L C + DV
Sbjct: 2000 GTYTCVAENTQAEARKDFVVAVLVAPRIRSSGVAREHHVLEGQEVRLDCEADGQPPPDVA 2059
Query: 589 WILLRTVNNRTMHYSISKQKMAITKEHSITLNLTIMNVSLQDSGTYACRARN 640
W+ + + M + + + +L + + D+G Y C A N
Sbjct: 2060 WLKDGSPLGQDMGPHL--------RFYLDGGSLVLKGLRASDAGAYTCVAHN 2103
Score = 63.5 bits (153), Expect = 6e-10
Identities = 83/365 (22%), Positives = 131/365 (35%), Gaps = 71/365 (19%)
Query: 296 LTIDKMQNKDKGLYTCRVRSGPSFKSVNTSVHIYDKAFITVKHRKQQVLETVAGKRSYRL 355
L I K+Q D G++TC S N ++ + + + V+ V L
Sbjct: 2178 LRISKVQLADAGIFTCVAASPAGVADRNFTLQVQVPPVLEPVEFQNDVV--VVRGSLVEL 2235
Query: 356 SMKVKAFPSPEVVWLKDGLPATEKSARYLTRGYSLIIKDVTEEDAGNYTILLSIKQSNVF 415
+ + P P V W+KDG P +S L +G SL ++ V D+G Y+ + +
Sbjct: 2236 PCEARGVPLPLVSWMKDGEPLLSQS---LEQGPSLQLEAVGAGDSGTYSCVAVSEAGEAR 2292
Query: 416 KNLTATLIVNVKPQIYEKAVSSFPDPALYPLGSRQILTCTAYGIPQPTIKWFWHPCNHNH 475
++ T++ P I + S P G+ L C A G PQP I W H
Sbjct: 2293 RHFQLTVME--PPHIED---SGQPTELSLTPGAPMELLCDAQGTPQPNITW--------H 2339
Query: 476 SEARCDFCSNNEESFILDADSNMGNRIESITQRMAIIEGKNKMASTLVVADSRISGIYIC 535
+ Q + +E ++ L V D +G+Y C
Sbjct: 2340 KDG----------------------------QALTRLENNSRATRVLRVRD---AGLYTC 2368
Query: 536 IASNKVGTVGRNISFYITDVPN-------GFHVNLEKMPTEGEDLKLSCTVNKFLYRDVT 588
+A + G + ++ + PN F V L L L C+V +T
Sbjct: 2369 LAESPAGAIEKSFRVRVQAPPNIVGPRGPRFVVGLAP-----GQLVLECSVEAEPAPKIT 2423
Query: 589 WILLRTVNNRTMHYSISKQKMAITKEHSITLNLTIMNVSLQDSGTYACRARNVYTGEEIL 648
W I Q+ A T+ L + +S DSG Y+C ARN +
Sbjct: 2424 W----------HRDGIVLQEDAHTQFPERGRFLQLQALSTADSGDYSCTARNAAGSTSVA 2473
Query: 649 QKKEI 653
+ EI
Sbjct: 2474 FRVEI 2478
Score = 61.2 bits (147), Expect = 3e-09
Identities = 116/594 (19%), Positives = 215/594 (36%), Gaps = 125/594 (21%)
Query: 91 TLTLNTAQANHTGFYSCKYLAVPTSKKKETESAIYIFISDTGRPFVEMYSEIPEIIHMTE 150
+L + AQA HTG YSC +A + + E + + + + E+ ++ + ++T
Sbjct: 1122 SLHVERAQAAHTGRYSC--VAENLAGRAERKFELSVLVPP------ELIGDLDPLTNITA 1173
Query: 151 GRE--LVIPCR---VTSPNITVTLKKFPL----DTLIPDGKRIIWDSRKGFIISNATYKE 201
L + C + P I + P+ DT + G ++ ++ ++
Sbjct: 1174 ALHSPLTLLCEAMGIPPPAIRWFRGEEPVSPGEDTYLLAGGWMLK-------MTQTQEQD 1226
Query: 202 IGLLTCEATVNGHLYKTNYLTHRQTNTIIDVQISTPRPVKLLRGHTLVLNCTATTPLNTR 261
GL +C A+ + N+ I+ + +K+L G T L C T + +
Sbjct: 1227 SGLYSCLASNEAGEARRNFSVEVLVPPSIENE-DLEEVIKVLDGQTAHLMCNVTG--HPQ 1283
Query: 262 VQMTWSYPDEKNKRASVRRRIDQSNSHANIFYSVLTIDKMQNKDKGLYTCRVRS--GPSF 319
++TW R H + +L + + G Y+C + G
Sbjct: 1284 PKLTWFKDGRPLARGDAH--------HISPDGVLLQVLQANLSSAGHYSCIAANAVGEKT 1335
Query: 320 KSVNTSVHIYDKAFITVKHRKQQVLETVAGKRSYRLSMKVKAFPSPEVVWLKDGLP-ATE 378
K SV + + + + TV L + AFPSP + W+KDG P
Sbjct: 1336 KHFQLSVLLAPTILGGAEDSADEEV-TVTVNNPISLICEALAFPSPNITWMKDGAPFEAS 1394
Query: 379 KSARYLTRGYSLIIKDVTEEDAGNYTILLSIKQSNVFKNLTATLIVNVKPQIYEKAVSSF 438
++ + L + L I + +EDAG YT +++ + KN ++ + P I +
Sbjct: 1395 RNIQLLPGTHGLQILNAQKEDAGQYTCVVTNELGEAVKNYHVEVL--IPPSISK------ 1446
Query: 439 PDPALYPLGSRQI---------LTCTAYGIPQPTIKWFWHPCNHNHSEARCDFCSNNEES 489
D L +G +++ L C ++ +P PTI+W+
Sbjct: 1447 -DDPLGEVGVKEVKTKVNSTLTLECESWAVPPPTIRWY---------------------- 1483
Query: 490 FILDADSNMGNRIESITQRMAIIEGKNKMASTLVVADSRISGIYICIASNKVGTVGRNIS 549
G + ++ + EG+ V+D SG Y+C+A+N G ++ +
Sbjct: 1484 -------KDGQPVTPSSRLQVLGEGRLLQIQPTQVSD---SGRYLCVATNVAGEDDQDFN 1533
Query: 550 FYITDVP-----NGFHVNLEKMPTEGE---------------DLKLSCTVNKFLYRDVTW 589
I P F E + E E L C N D+TW
Sbjct: 1534 VLIQVPPMFQKVGDFSAAFEILSREEEARGGVTEYREIVENNPAYLYCDTNAIPPPDLTW 1593
Query: 590 ILLRTVNNRTMHYSISKQKMAITKEHSITLNLTIMNVSL---QDSGTYACRARN 640
Q ++ E S+ ++ + L +++G Y+C+A N
Sbjct: 1594 YR-------------EDQPLSAGDEVSVLQGGRVLQIPLVRAENAGRYSCKASN 1634
Score = 61.2 bits (147), Expect = 3e-09
Identities = 126/589 (21%), Positives = 218/589 (37%), Gaps = 105/589 (17%)
Query: 69 KESERLSITKSACGRNGKQFCSTLTLNTAQANHTGFYSCKYLAVPTSKKKETESAIYIFI 128
K+S+ LS+ + G TL L A+ + +G Y+C+ L +K + ++ +
Sbjct: 1782 KDSQALSLGEEVFLLPGTH---TLQLGRARLSDSGMYTCEALNAAGRDQKLVQLSVLV-- 1836
Query: 129 SDTGRPFVEMYSEIPE-IIHMTEGRELVIPCRVTS-PNITVTLKKFPLDTLIPDGKRIIW 186
P P+ + + G + V+ C + P TVT K DG+ ++
Sbjct: 1837 ----PPAFRQAPRGPQDAVLVRVGDKAVLSCETDALPEPTVTWYK--------DGQPLVL 1884
Query: 187 DSRKGFI-------ISNATYKEIGLLTCEAT-VNGHLYKTNYLTHRQTNTIIDVQISTPR 238
R + I A + GL +C+ + V G +T LT + T + + T
Sbjct: 1885 AQRTQALRGGQRLEIQEAQVSDKGLYSCKVSNVAGEAVRTFTLTVQVPPTFENPKTET-- 1942
Query: 239 PVKLLRGHTLVLNCTAT-TPLNTRVQMTWSYPDEKNKRASVRRRIDQSNSHANIFYSVLT 297
V + G LVL C + P T +TW + ++V + + L
Sbjct: 1943 -VSQVAGSPLVLTCDVSGVPAPT---VTWLKDRMPVESSAVHGVVSRGGR--------LQ 1990
Query: 298 IDKMQNKDKGLYTCRVRS--GPSFKSVNTSVHIYDKAFITVKHRKQQVLETVAGKRSYRL 355
+ ++Q G YTC + + K +V + + + R+ VLE + RL
Sbjct: 1991 LSRLQPAQAGTYTCVAENTQAEARKDFVVAVLVAPRIRSSGVAREHHVLEG----QEVRL 2046
Query: 356 SMKVKAFPSPEVVWLKDGLPATEKSA---RYLTRGYSLIIKDVTEEDAGNYTILLSIKQS 412
+ P P+V WLKDG P + R+ G SL++K + DAG YT +
Sbjct: 2047 DCEADGQPPPDVAWLKDGSPLGQDMGPHLRFYLDGGSLVLKGLRASDAGAYTCVAHNPAG 2106
Query: 413 NVFKNLTATLIVNVKPQIYEKAVSSFPDPALYPLGSRQILTCTAYGIPQPTIKWFWHPCN 472
+ T ++ V P I + A S + G + C G P + W
Sbjct: 2107 EDARLHTVNVL--VPPTIKQGADGS--GTLVSRPGELVTMVCPVRGSPPIHVSWL----- 2157
Query: 473 HNHSEARCDFCSNNEESFILDADSNMGNRIESITQRMAII-EGKNKMASTLVVADSRISG 531
++ L ++QR + G S + +AD +G
Sbjct: 2158 --------------KDGLPL-----------PLSQRTLLHGSGHTLRISKVQLAD---AG 2189
Query: 532 IYICIASNKVGTVGRNISFYITDVPNGFHVNLEK--MPTEGEDLKLSCTVNKFLYRDVTW 589
I+ C+A++ G RN + + P V + + G ++L C V+W
Sbjct: 2190 IFTCVAASPAGVADRNFTLQVQVPPVLEPVEFQNDVVVVRGSLVELPCEARGVPLPLVSW 2249
Query: 590 ILLRTVNNRTMHYSISKQKMAITKEHSITLNLTIMNVSLQDSGTYACRA 638
+ + ++ + E +L L V DSGTY+C A
Sbjct: 2250 M------------KDGEPLLSQSLEQGPSLQLEA--VGAGDSGTYSCVA 2284
Score = 59.3 bits (142), Expect = 1e-08
Identities = 48/172 (27%), Positives = 75/172 (43%), Gaps = 7/172 (4%)
Query: 296 LTIDKMQNKDKGLYTCRVRSGPSFKSVNTSVHIYDKAFITVKHRKQQVLETVAGKRSYRL 355
L + + Q+ D G+YTC+ + T + +Y I + V++ VAG R L
Sbjct: 367 LQLGRAQSSDAGVYTCKASNAVGAAEKATRLDVYVPPTIEGAGGRPYVVKAVAG-RPVAL 425
Query: 356 SMKVKAFPSPEVVWLKDGLPATEKS-ARYLTRGYSLIIKDVTEEDAGNYTILLSIKQSNV 414
+ PSP + W +GLP E + +R T G L ++ E +G Y+ + S
Sbjct: 426 ECVARGHPSPTLSWHHEGLPVAESNESRLETDGSVLRLESPGEASSGLYSCVASSPAGEA 485
Query: 415 FKNLTATLIVNVKPQIYEKAVSSFPDPALYPLGSRQILTCTAYGIPQPTIKW 466
L ++ V V PQ+ V+ +G L C A G P PTI+W
Sbjct: 486 V--LQYSVEVQVPPQL---LVAEGLGQVTTIVGQPLELPCQASGSPVPTIQW 532
Score = 58.9 bits (141), Expect = 1e-08
Identities = 79/364 (21%), Positives = 134/364 (36%), Gaps = 66/364 (18%)
Query: 288 HANIFYSVLTIDKMQNKDKGLYTCRVRS--GPSFKSVNTSVHIYDKAFITVKHRKQQVLE 345
H + +L + + Q +G YTC + G S + + VH+ + R+
Sbjct: 1021 HVSAVGRLLYLGQAQLAQEGTYTCECSNVVGNSSQDLQLEVHVPPQI---AGPREPPTQV 1077
Query: 346 TVAGKRSYRLSMKVKAFPSPEVVWLKDGLPA-TEKSARYLTRGYSLIIKDVTEEDAGNYT 404
+V L P P V W +DG P E + +G SL ++ G Y+
Sbjct: 1078 SVVQDGVATLECNATGKPPPTVTWERDGQPVGAELGLQLQNQGQSLHVERAQAAHTGRYS 1137
Query: 405 ILLSIKQSNVFKNLTATLIVNVKPQIYEKAVSSFPDPALY---PLGSRQILTCTAYGIPQ 461
+ + +++V P++ DP L S L C A GIP
Sbjct: 1138 CVAENLAGRAERKFELSVLV--PPELIGDL-----DPLTNITAALHSPLTLLCEAMGIPP 1190
Query: 462 PTIKWFWHPCNHNHSEARCDFCSNNEESFILDADSNMGNRIESITQRMAIIEGKNKMAST 521
P I+WF + S E++++L G + +TQ
Sbjct: 1191 PAIRWFRGE----------EPVSPGEDTYLL-----AGGWMLKMTQ-------------- 1221
Query: 522 LVVADSRISGIYICIASNKVGTVGRNISFYITDVPNGFHVNLEKM--PTEGEDLKLSCTV 579
+ SG+Y C+ASN+ G RN S + P+ + +LE++ +G+ L C V
Sbjct: 1222 ---TQEQDSGLYSCLASNEAGEARRNFSVEVLVPPSIENEDLEEVIKVLDGQTAHLMCNV 1278
Query: 580 NKFLYRDVTWILLRTVNNRTMHYSISKQKMAITKEHSIT---LNLTIMNVSLQDSGTYAC 636
+TW + +A H I+ + L ++ +L +G Y+C
Sbjct: 1279 TGHPQPKLTWFK-------------DGRPLARGDAHHISPDGVLLQVLQANLSSAGHYSC 1325
Query: 637 RARN 640
A N
Sbjct: 1326 IAAN 1329
Score = 58.5 bits (140), Expect = 2e-08
Identities = 112/564 (19%), Positives = 207/564 (36%), Gaps = 106/564 (18%)
Query: 92 LTLNTAQANHTGFYSCKYLAVPTSKKKETESAIYIFISDTGRPFVEMYSEIPEIIHMTEG 151
L + A H G Y+C +++ + ++F++ P V+ +P ++
Sbjct: 2721 LEIGQALPIHAGRYTC------SARNSAGVAHKHVFLTVQASPVVK---PLPSVVRAVAE 2771
Query: 152 RELVIPCRVTS-PNITVTLKKFPLDTLIPDGKRIIWDSRKGFIISNATYKEIGLLTCEA- 209
E+++PC + P T+T +K L+ +++ + I++A+ ++ G C A
Sbjct: 2772 EEVLLPCEASGIPRPTITWQKEGLNVATGVSTQVLPGGQ--LRIAHASPEDAGNYLCIAK 2829
Query: 210 -TVNGHLYKTNYLTHRQTNTIIDVQISTPRPVKLLRGHTLVLNCTATTPLNTRVQMTWSY 268
+ + KT + Q +I+ + + G L C A + +TW
Sbjct: 2830 NSAGSAMGKTRLVV--QVPPVIENGLPD---LSTTEGSHAFLPCKARG--SPEPNITWDK 2882
Query: 269 PDEKNKRASVRRRIDQSNSHANIFYSVLTIDKMQNKDKGLYTCRVRS--GPSFKSVNTSV 326
+ A + I S L + ++ +D G YTC + G + + V+ ++
Sbjct: 2883 DGQPVSGAEGKFTIQPSGE--------LLVKNLEGQDAGTYTCTAENAVGRARRRVHLTI 2934
Query: 327 HIYDKAFITVKHRKQQVLETVAGKRSYRLSMKV------KAFPSPEVVWLKDGLPATEKS 380
+ V T+ G RS RL ++ + P+P + W + P TE
Sbjct: 2935 LVLP------------VFTTLPGDRSLRLGDRLWLRCAARGSPTPRIGWTVNDRPVTEGV 2982
Query: 381 ARYLTRGYSLIIKDVTEEDAGNYTILLSIKQSNVFKNLTATLIVNVK--PQIYEKAVSSF 438
+ G +L V+ ED+G Y N A V+VK P + +A S
Sbjct: 2983 SEQ-DGGSTLQRAAVSREDSGTYVCWAE----NRVGRTQAVSFVHVKEAPVLQGEAFSYL 3037
Query: 439 PDPALYPLGSRQILTCTAYGIPQPTIKWFWHPCNHNHSEARCDFCSNNEESFILDADSNM 498
+P +G L C G P P I W I D
Sbjct: 3038 VEP----VGGSIQLDCVVRGDPVPDIHW------------------------IKDGLPLR 3069
Query: 499 GNRIESITQRMAIIEGKNKMASTLVVADSRISGIYICIASNKVGTVGRNISFYITDVPNG 558
G+ + Q ++ T+ + +G Y C+A N++G + + + P
Sbjct: 3070 GSHLRHQLQNGSL---------TIHRTERDDAGRYQCLAENEMGVAKKVVILVLQSAPV- 3119
Query: 559 FHVNLEKMPTE-GEDLKLSCTVNKFLYRDVTWILLRTVNNRTMHYSISKQKMAITKEHSI 617
F V + M G+D+ L C + W+ + + +++ + S+
Sbjct: 3120 FQVEPQDMTVRSGDDVALRCQATGEPTPTIEWL-------QAGQPLRASRRLRTLPDGSL 3172
Query: 618 TLNLTIMNVSLQDSGTYACRARNV 641
L NV D+GTY C A N+
Sbjct: 3173 WLE----NVETGDAGTYDCVAHNL 3192
Score = 57.0 bits (136), Expect = 6e-08
Identities = 132/599 (22%), Positives = 209/599 (34%), Gaps = 109/599 (18%)
Query: 94 LNTAQAN--HTGFYSCKYLAVPTSKKKETESAIYIFISDTGRPFVEMYSEIPEIIHMTEG 151
L QAN G YSC +A +K + + ++ T E ++ E + +T
Sbjct: 1310 LQVLQANLSSAGHYSC--IAANAVGEKTKHFQLSVLLAPTILGGAEDSAD--EEVTVTVN 1365
Query: 152 RELVIPCRVT---SPNITVTLKKFPLDTLIPDGKRI-IWDSRKGFIISNATYKEIGLLTC 207
+ + C SPNIT P + + I + G I NA ++ G TC
Sbjct: 1366 NPISLICEALAFPSPNITWMKDGAPFEA----SRNIQLLPGTHGLQILNAQKEDAGQYTC 1421
Query: 208 EATVNGHLYKTNYLTHRQTNTIIDVQISTPRP--------VKLLRGHTLVLNCT--ATTP 257
T NY +I IS P VK TL L C A P
Sbjct: 1422 VVTNELGEAVKNY----HVEVLIPPSISKDDPLGEVGVKEVKTKVNSTLTLECESWAVPP 1477
Query: 258 LNTRVQMTWSYPDEKNKRASVRRRIDQSNSHANIFYSVLTIDKMQNKDKGLYTCRVRS-- 315
R W Y D + S R ++ +L I Q D G Y C +
Sbjct: 1478 PTIR----W-YKDGQPVTPSSRLQVLGEGR-------LLQIQPTQVSDSGRYLCVATNVA 1525
Query: 316 GPSFKSVNTSVHI---------YDKAFITVKHRKQ------QVLETVAGKRSYRLSMKVK 360
G + N + + + AF + ++ + E V +Y L
Sbjct: 1526 GEDDQDFNVLIQVPPMFQKVGDFSAAFEILSREEEARGGVTEYREIVENNPAY-LYCDTN 1584
Query: 361 AFPSPEVVWLKDGLPATE-KSARYLTRGYSLIIKDVTEEDAGNYTILLSIKQSN-VFKNL 418
A P P++ W ++ P + L G L I V E+AG Y S K SN V ++
Sbjct: 1585 AIPPPDLTWYREDQPLSAGDEVSVLQGGRVLQIPLVRAENAGRY----SCKASNEVGEDW 1640
Query: 419 TATLIVNVKPQIYEKAVSSFPDPALYPLGSRQILTCTAYGIPQPTIKWFWHPCNHNHSEA 478
++ + P + + S L C A G P PTI W
Sbjct: 1641 LHYELLVLTPPVILGDTEELVEEVTVNASSTVSLQCPALGNPVPTISWL----------- 1689
Query: 479 RCDFCSNNEESFILDADSNMGNRIESITQRMAIIE-GKNKMASTLVVADSRISGIYICIA 537
N F S + R+ ++E G+ ST VAD+ Y+C+A
Sbjct: 1690 ------QNGLPF-------------SPSPRLQVLEDGQVLQVSTAEVADA---ASYMCVA 1727
Query: 538 SNKVGTVGRNISFYITDVPNGFHVNLEKMPTE-GEDLKLSCTVNKFLYRDVTWILLRTVN 596
N+ G+ + + + P ++LE++ + L C V+ +VTW
Sbjct: 1728 ENQAGSAEKLFTLRVQVPPRIAGLDLEQVTAILNSSVSLPCDVHAHPNPEVTWY------ 1781
Query: 597 NRTMHYSISKQKMAITKEHSITLNLTIMNVSLQDSGTYACRARNVYTGEEILQKKEITI 655
+ S+ ++ + H++ L L DSG Y C A N ++ L + + +
Sbjct: 1782 KDSQALSLGEEVFLLPGTHTLQLG----RARLSDSGMYTCEALNAAGRDQKLVQLSVLV 1836
Score = 56.6 bits (135), Expect = 7e-08
Identities = 65/294 (22%), Positives = 111/294 (37%), Gaps = 53/294 (18%)
Query: 352 SYRLSMKVKAFPSPEVVWLKDGLPATEKSARYLTRG-YSLIIKDVTEEDAGNYTILLSIK 410
S L V A P+PEV W KD + +L G ++L + D+G YT
Sbjct: 1763 SVSLPCDVHAHPNPEVTWYKDSQALSLGEEVFLLPGTHTLQLGRARLSDSGMYTCEALNA 1822
Query: 411 QSNVFKNLTATLIVNVKPQIYEKAVSSFPDPALYPLGSRQILTCTAYGIPQPTIKWFWHP 470
K + +++V P + +A D L +G + +L+C +P+PT+ W+
Sbjct: 1823 AGRDQKLVQLSVLV---PPAFRQAPRGPQDAVLVRVGDKAVLSCETDALPEPTVTWY--- 1876
Query: 471 CNHNHSEARCDFCSNNEESFILDADSNMGNRIESITQRMAIIEGKNKMASTLVVADSRIS 530
+ + +L QR + G + L + ++++S
Sbjct: 1877 --------------KDGQPLVL-------------AQRTQALRGGQR----LEIQEAQVS 1905
Query: 531 --GIYICIASNKVGTVGRNISFYITDVPNGFHVNLEKM-PTEGEDLKLSCTVNKFLYRDV 587
G+Y C SN G R + + P + E + G L L+C V+ V
Sbjct: 1906 DKGLYSCKVSNVAGEAVRTFTLTVQVPPTFENPKTETVSQVAGSPLVLTCDVSGVPAPTV 1965
Query: 588 TWILLR-TVNNRTMHYSISKQKMAITKEHSITLNLTIMNVSLQDSGTYACRARN 640
TW+ R V + +H +S+ L + + +GTY C A N
Sbjct: 1966 TWLKDRMPVESSAVHGVVSRGG-----------RLQLSRLQPAQAGTYTCVAEN 2008
Score = 55.1 bits (131), Expect = 2e-07
Identities = 82/351 (23%), Positives = 122/351 (34%), Gaps = 61/351 (17%)
Query: 296 LTIDKMQNKDKGLYTCRVR--SGPSFKSVNTSVHIYDKAFITVKHRKQQVLETVAGKRSY 353
L I+K+ +D+G+YTC +G S + V K + V + V S
Sbjct: 659 LQIEKVDLRDEGIYTCAATNLAGESKREVAL------KVLVPPNIEPGPVNKAVLENASV 712
Query: 354 RLSMKVKAFPSPEVVWLKDGLPATE-KSARYLTRGYSLIIKDVTEEDAGNYTILLSIKQS 412
L P P+V W K P + G L I+ DAG+Y + S
Sbjct: 713 TLECLASGVPPPDVSWFKGHQPVSSWMGVTVSVDGRVLRIEQAQLSDAGSYRCVASNVAG 772
Query: 413 NVFKNLTATLIVNVKPQIYEKAVSSFPDPALYPLGSRQILTCTAYGIPQPTIKWFWHPCN 472
+ L L VNV P+I S P P L R LTC A G P PT+ W
Sbjct: 773 ST--ELRYGLRVNVPPRI--TLPPSLPGPVLVNTPVR--LTCNATGAPSPTLMWL----- 821
Query: 473 HNHSEARCDFCSNNEESFILDADSNMGNRIESI-TQRMAIIEGKNKMASTLVVADSRISG 531
GN + T + + G + TL A + SG
Sbjct: 822 ------------------------KDGNPVSPAGTPGLQVFPGGRVL--TLASARASDSG 855
Query: 532 IYICIASNKVGTVGRNISFYITDVPNGFHVNLEKMPTEGEDLKLSCTVNKFLYRDVTWIL 591
Y C+A + VG +++ + P+ L E + L C + ++W
Sbjct: 856 RYSCVAVSAVGEDRQDVVLQVHMPPSILGEELNVSVVANESVALECQSHAMPPPVLSWWK 915
Query: 592 -LRTVNNRT-MHYSISKQKMAITKEHSITLNLTIMNVSLQDSGTYACRARN 640
R + R +H S K + + + + D+G Y C A N
Sbjct: 916 DGRPLEPRPGVHLSADKALLQVDR------------ADVWDAGHYTCEALN 954
Score = 53.1 bits (126), Expect = 8e-07
Identities = 110/506 (21%), Positives = 185/506 (36%), Gaps = 85/506 (16%)
Query: 160 VTSPNITVTLKKFPLDTLIPDGKRIIWD-SRKGFIISNATYKEIGLLTCEATVNGHLYKT 218
V +PNIT F L+P ++++ + + A + G+ TC+A+
Sbjct: 338 VPTPNITW----FKDGALLPTSTKVVYTRGGRQLQLGRAQSSDAGVYTCKAS-------- 385
Query: 219 NYLTHRQTNTIIDVQI--------STPRPVKLLRGHTLVLNCTATTPLNTRVQMTWSYPD 270
N + + T +DV + P VK + G + L C A T S+
Sbjct: 386 NAVGAAEKATRLDVYVPPTIEGAGGRPYVVKAVAGRPVALECVA----RGHPSPTLSWHH 441
Query: 271 EKNKRASVRRRIDQSNSHANIFYSVLTIDKMQNKDKGLYTCRVRSGPSFKSV-NTSVHIY 329
E A + + S SVL ++ GLY+C V S P+ ++V SV +
Sbjct: 442 EGLPVA------ESNESRLETDGSVLRLESPGEASSGLYSC-VASSPAGEAVLQYSVEVQ 494
Query: 330 DKAFITVKHRKQQVLETVAGKRSYRLSMKVKAFPSPEVVWLKDGLPATE-KSARYLTRGY 388
+ V QV T+ G+ L + P P + WL++G PA E + ++G
Sbjct: 495 VPPQLLVAEGLGQVT-TIVGQ-PLELPCQASGSPVPTIQWLQNGRPAEELAGVQVASQGT 552
Query: 389 SLIIKDVTEEDAGNYTILLSIKQSNVFKNLTATLIVNVKPQIYEKAVSSFPDPALYPLGS 448
+L I V + +G L + + +N A + V+V + P P+G
Sbjct: 553 TLHIDHVELDHSG----LFACQATNEAGTAGAEVEVSVHGE-------WAPGVLEVPIG- 600
Query: 449 RQILTCTAYGIPQPTIKWFWHPCNHNHSEARCD-----FCSNNEESFILDADSNMGNRIE 503
++ W +H+ A CD + + +++ + G
Sbjct: 601 ----------------QYHWGXEHHSSFPAACDPPVHRGWGAHPKPPLVEGWCSPG---- 640
Query: 504 SITQRMAIIEGKNKMASTLVV--ADSRISGIYICIASNKVGTVGRNISFYITDVPNGFHV 561
S+ I + L + D R GIY C A+N G R ++ + PN
Sbjct: 641 SLWGEPTGIPVAYSLPPPLQIEKVDLRDEGIYTCAATNLAGESKREVALKVLVPPNIEPG 700
Query: 562 NLEKMPTEGEDLKLSCTVNKFLYRDVTWILLRTVNNRTMHYSISKQKMAITKEHSITLNL 621
+ K E + L C + DV+W + M ++S L
Sbjct: 701 PVNKAVLENASVTLECLASGVPPPDVSWFKGHQPVSSWMGVTVSVDGRV----------L 750
Query: 622 TIMNVSLQDSGTYACRARNVYTGEEI 647
I L D+G+Y C A NV E+
Sbjct: 751 RIEQAQLSDAGSYRCVASNVAGSTEL 776
Score = 52.4 bits (124), Expect = 1e-06
Identities = 92/372 (24%), Positives = 136/372 (36%), Gaps = 63/372 (16%)
Query: 295 VLTIDKMQNKDKGLYTCRVRSGPSFKSVNTSVHIYDKAFITVKHRKQQVLETVAGKRSYR 354
VL I D+G Y C S ++ + + ++ I + +V V +
Sbjct: 273 VLRITGSHVGDEGRYQCVAFSPAGQQARDFQLRVHAPPTIWGSNETGEV--AVMEDHLVQ 330
Query: 355 LSMKVKAFPSPEVVWLKDG-LPATEKSARYLTRGYSLIIKDVTEEDAGNYTILLSIKQSN 413
L + + P+P + W KDG L T Y G L + DAG YT K SN
Sbjct: 331 LLCEARGVPTPNITWFKDGALLPTSTKVVYTRGGRQLQLGRAQSSDAGVYT----CKASN 386
Query: 414 VF--KNLTATLIVNVKPQIYEKAVSSFPDPALYPLGSRQILTCTAYGIPQPTIKWFWHPC 471
L V V P I + P G L C A G P PT+ W
Sbjct: 387 AVGAAEKATRLDVYVPPTI--EGAGGRPYVVKAVAGRPVALECVARGHPSPTLSW----- 439
Query: 472 NHNHSEARCDFCSNNEESFILDADSNMGNRIESITQRMAIIEGKNKMASTLVVADSRISG 531
H E +NE L+ D ++ R+ES SG
Sbjct: 440 ---HHEG-LPVAESNESR--LETDGSV-LRLES--------------------PGEASSG 472
Query: 532 IYICIASNKVGTVGRNISFYITDVPNGFHV--NLEKMPT-EGEDLKLSCTVNKFLYRDVT 588
+Y C+AS+ G S + VP V L ++ T G+ L+L C + +
Sbjct: 473 LYSCVASSPAGEAVLQYSVEV-QVPPQLLVAEGLGQVTTIVGQPLELPCQASGSPVPTIQ 531
Query: 589 WILLRTVNNRTMHYSISKQKMAITKEHSITLNLTIMNVSLQDSGTYACRARNV--YTGEE 646
W+ N R +++A + S L I +V L SG +AC+A N G E
Sbjct: 532 WL----QNGR------PAEELAGVQVASQGTTLHIDHVELDHSGLFACQATNEAGTAGAE 581
Query: 647 ILQKKEITIRGE 658
+ E+++ GE
Sbjct: 582 V----EVSVHGE 589
Score = 52.0 bits (123), Expect = 2e-06
Identities = 86/382 (22%), Positives = 141/382 (36%), Gaps = 45/382 (11%)
Query: 91 TLTLNTAQANHTGFYSCKYLAVPTSKKKETESAIYIFISDTGRPFVEMYSEIPEIIHMTE 150
+L L A +G YSC V S+ E + + + P +E + P + +T
Sbjct: 2266 SLQLEAVGAGDSGTYSC----VAVSEAGEARRHFQLTVMEP--PHIEDSGQ-PTELSLTP 2318
Query: 151 GRELVIPCRVT-SPNITVTLKKFPLDTLIPDGKRIIWDSRKGFIISNATYKEIGLLTCEA 209
G + + C +P +T K DG+ + ++ GL TC A
Sbjct: 2319 GAPMELLCDAQGTPQPNITWHK--------DGQALTRLENNSRATRVLRVRDAGLYTCLA 2370
Query: 210 TVNGHLYKTNYLTHRQTNTIIDVQISTPRPVKLLRGHTLVLNCTATTPLNTRVQMTWSYP 269
+ ++ Q I V PR V L LVL C+ ++ TW
Sbjct: 2371 ESPAGAIEKSFRVRVQAPPNI-VGPRGPRFVVGLAPGQLVLECSVEAEPAPKI--TWH-- 2425
Query: 270 DEKNKRASVRRRIDQSNSHANIFYS--VLTIDKMQNKDKGLYTCRVRSGPSFKSVNTSVH 327
R + + Q ++H L + + D G Y+C R+ SV V
Sbjct: 2426 -----RDGI---VLQEDAHTQFPERGRFLQLQALSTADSGDYSCTARNAAGSTSVAFRVE 2477
Query: 328 IYDKAFITVKHRKQQVLETVAGKRSYRLSMKVKAFPSPEVVWLKDGLPATEKSARY--LT 385
I+ I R V+ ++ L + P+P V W KD +P +S R+ L
Sbjct: 2478 IHTVPTI----RSGPPAVNVSVNQTALLPCQADGVPAPLVSWRKDRVPLDPRSPRFEILP 2533
Query: 386 RGYSLIIKDVTEEDAGNYTILLSIKQSNVFKNLTATLIVNVKPQIYEKAVSSFPDPALYP 445
G SL I+ V +DAG+Y L S + + + + A++ P
Sbjct: 2534 EG-SLRIQPVLAQDAGHYLCLASNSAGSDRQGRDLRV-------LEPPAIAPSPSNLTLT 2585
Query: 446 LGSRQILTCTAYGIPQPTIKWF 467
+ +L C A G P+P + W+
Sbjct: 2586 AHTPALLPCEASGSPKPLVVWW 2607
Score = 45.4 bits (106), Expect = 2e-04
Identities = 49/184 (26%), Positives = 69/184 (37%), Gaps = 14/184 (7%)
Query: 288 HANIFYSVLTIDKMQNKDKGLYTCRV--RSGPSFKSVNTSVHIYDKAFITVKHRKQQVLE 345
H + ++L +D+ D G YTC ++G S K N +V + + H
Sbjct: 927 HLSADKALLQVDRADVWDAGHYTCEALNQAGRSEKHYNLNVWVAPVFPLRESHTL----- 981
Query: 346 TVAGKRSYRLSMKVKAFPSPEVVWLKDGLPATEKSA---RYLTRGYSLIIKDVTEEDAGN 402
TV LS + + P P++ W KDG P + A G L + G
Sbjct: 982 TVREGHPTSLSCECRGVPFPKISWRKDGQPLPGEGAGLQHVSAVGRLLYLGQAQLAQEGT 1041
Query: 403 YTILLSIKQSNVFKNLTATLIVNVKPQIYEKAVSSFPDPALYPLGSRQILTCTAYGIPQP 462
YT S N ++L L V+V PQI P L C A G P P
Sbjct: 1042 YTCECSNVVGNSSQDL--QLEVHVPPQI--AGPREPPTQVSVVQDGVATLECNATGKPPP 1097
Query: 463 TIKW 466
T+ W
Sbjct: 1098 TVTW 1101
Score = 44.3 bits (103), Expect = 4e-04
Identities = 80/369 (21%), Positives = 135/369 (36%), Gaps = 76/369 (20%)
Query: 295 VLTIDKMQNKDKGLYTCRVRSGPSFKSVNTSVHIYDKAFIT---VKHRKQQVLETVAGKR 351
VL I ++ ++ G Y+C+ + V Y+ +T + ++++E V
Sbjct: 1614 VLQIPLVRAENAGRYSCKASN-----EVGEDWLHYELLVLTPPVILGDTEELVEEVTVNA 1668
Query: 352 SYRLSMKVKAF--PSPEVVWLKDGLP-ATEKSARYLTRGYSLIIKDVTEEDAGNYTILLS 408
S +S++ A P P + WL++GLP + + L G L + DA +Y +
Sbjct: 1669 SSTVSLQCPALGNPVPTISWLQNGLPFSPSPRLQVLEDGQVLQVSTAEVADAASYMCVAE 1728
Query: 409 IKQSNVFKNLTATLIVNVKPQIYEKAVSSFPDPALYPLGSRQILTCTAYGIPQPTIKWFW 468
+ + K T L V V P+I + + L S L C + P P + W+
Sbjct: 1729 NQAGSAEKLFT--LRVQVPPRIAGLDL----EQVTAILNSSVSLPCDVHAHPNPEVTWY- 1781
Query: 469 HPCNHNHSEARCDFCSNNEESFILDADSNMGNRIESITQRMAIIEGKNKMASTLVVADSR 528
S+A S EE F+L TL + +R
Sbjct: 1782 -----KDSQA----LSLGEEVFLLPG------------------------THTLQLGRAR 1808
Query: 529 IS--GIYICIASNKVGTVGRNISFYITDVPNGFHVNLEKMPTE------GEDLKLSCTVN 580
+S G+Y C A N G + + + VP F + P + G+ LSC +
Sbjct: 1809 LSDSGMYTCEALNAAGRDQKLVQLSVL-VPPAFR-QAPRGPQDAVLVRVGDKAVLSCETD 1866
Query: 581 KFLYRDVTWILLRTVNNRTMHYSISKQKMAITKEHSIT--LNLTIMNVSLQDSGTYACRA 638
VTW Y + + + ++ L I + D G Y+C+
Sbjct: 1867 ALPEPTVTW------------YKDGQPLVLAQRTQALRGGQRLEIQEAQVSDKGLYSCKV 1914
Query: 639 RNVYTGEEI 647
NV GE +
Sbjct: 1915 SNV-AGEAV 1922
Score = 42.0 bits (97), Expect = 0.002
Identities = 42/175 (24%), Positives = 68/175 (38%), Gaps = 15/175 (8%)
Query: 295 VLTIDKMQNKDKGLYTCRVRS--GPSFKSVNTSVHIYDKAFITVKHRKQQVLETVAGKRS 352
VLT+ + D G Y+C S G + V VH+ +++ +V S
Sbjct: 843 VLTLASARASDSGRYSCVAVSAVGEDRQDVVLQVHMPPSIL------GEELNVSVVANES 896
Query: 353 YRLSMKVKAFPSPEVVWLKDGLPATEKSARYLTRGYSLIIKDVTEE-DAGNYTILLSIKQ 411
L + A P P + W KDG P + +L+ +L+ D + DAG+YT +
Sbjct: 897 VALECQSHAMPPPVLSWWKDGRPLEPRPGVHLSADKALLQVDRADVWDAGHYTCEALNQA 956
Query: 412 SNVFKNLTATLIVNVKPQIYEKAVSSFPDPALYPLGSRQILTCTAYGIPQPTIKW 466
K+ + V + E + + G L+C G+P P I W
Sbjct: 957 GRSEKHYNLNVWVAPVFPLRESHTLTVRE------GHPTSLSCECRGVPFPKISW 1005
Score = 38.5 bits (88), Expect = 0.021
Identities = 30/115 (26%), Positives = 51/115 (44%), Gaps = 10/115 (8%)
Query: 355 LSMKVKAFPSPEVVWLKDGLPAT---EKSARYLTRGYSLIIKDVTEEDAGNYTILLSIKQ 411
L + P P VVW KDG ++ A L +L++ +D+ + ++S +
Sbjct: 2592 LPCEASGSPKPLVVWWKDGQKLDFRLQQGAYRLLPSNALLLTAPGPQDSAQFECVVSNEV 2651
Query: 412 SNVFKNLTATLIVNVKPQIYEKAVSSFPDPALYPLGSRQILTCTAYGIPQPTIKW 466
+ T V+V P I + + F + P+ +LTC + GIP PT+ W
Sbjct: 2652 GEAHRLYQVT--VHVPPTIADDQ-TDFTVTMMAPV----VLTCHSTGIPAPTVSW 2699
Score = 37.7 bits (86), Expect = 0.036
Identities = 40/178 (22%), Positives = 69/178 (38%), Gaps = 17/178 (9%)
Query: 295 VLTIDKMQNKDKGLYTCRVRSGPSFKSVNTSVHIYDKAFITVKHRKQQVLETVAGKRSYR 354
VL I++ Q D G Y C + + + + IT+ + V R
Sbjct: 749 VLRIEQAQLSDAGSYRCVASNVAGSTELRYGLRVNVPPRITLP---PSLPGPVLVNTPVR 805
Query: 355 LSMKVKAFPSPEVVWLKDG---LPATEKSARYLTRGYSLIIKDVTEEDAGNYTILLSIKQ 411
L+ PSP ++WLKDG PA + G L + D+G Y+ +
Sbjct: 806 LTCNATGAPSPTLMWLKDGNPVSPAGTPGLQVFPGGRVLTLASARASDSGRYSCVAVSAV 865
Query: 412 SNVFKNLTATLIVNVKPQIY--EKAVSSFPDPALYPLGSRQILTCTAYGIPQPTIKWF 467
+++ L V++ P I E VS + ++ L C ++ +P P + W+
Sbjct: 866 GEDRQDV--VLQVHMPPSILGEELNVSVVANESV-------ALECQSHAMPPPVLSWW 914
Score = 37.0 bits (84), Expect = 0.061
Identities = 90/417 (21%), Positives = 144/417 (34%), Gaps = 69/417 (16%)
Query: 77 TKSACGRNGKQFCSTLTLNTAQANHTGFYSCKYLAVPTSKKKETESAIYIFISDTGRPFV 136
TK R G+Q L L AQ++ G Y+CK + +K T +Y+ P +
Sbjct: 356 TKVVYTRGGRQ----LQLGRAQSSDAGVYTCKASNAVGAAEKATRLDVYV------PPTI 405
Query: 137 EMYSEIPEIIHMTEGRELVIPCRVTS-PNITVTLKKFPLDTLIPDGKRIIWDSRKGFIIS 195
E P ++ GR + + C P+ T++ L + R+ D +
Sbjct: 406 EGAGGRPYVVKAVAGRPVALECVARGHPSPTLSWHHEGLPVAESNESRLETDG-SVLRLE 464
Query: 196 NATYKEIGLLTCEATVNGHLYKTNYLTHRQTNTIIDVQISTPRPVKLLRGHTLVLNCTAT 255
+ GL +C A+ Y Q + V + V + G L L C A+
Sbjct: 465 SPGEASSGLYSCVASSPAGEAVLQYSVEVQVPPQLLVAEGLGQ-VTTIVGQPLELPCQAS 523
Query: 256 -TPLNTRVQMTWSYPDEKNKRASVRRRIDQSNSHANIFYSVLTIDKMQNKDKGLYTCRV- 313
+P+ T + P E+ V + + L ID ++ GL+ C+
Sbjct: 524 GSPVPTIQWLQNGRPAEELAGVQVASQ-----------GTTLHIDHVELDHSGLFACQAT 572
Query: 314 -RSGPSFKSVNTSVHIYDKAFITVKHRKQQVLETVAGKRSYRLSMKVK------------ 360
+G + V SVH VLE G+ +
Sbjct: 573 NEAGTAGAEVEVSVH---------GEWAPGVLEVPIGQYHWGXEHHSSFPAACDPPVHRG 623
Query: 361 --AFPSPEVV--WLKDGLPATEKSARYLTRGYS----LIIKDVTEEDAGNYTILLSIKQS 412
A P P +V W G E + + YS L I+ V D G YT +
Sbjct: 624 WGAHPKPPLVEGWCSPGSLWGEPTG--IPVAYSLPPPLQIEKVDLRDEGIYTCAATNLAG 681
Query: 413 NVFKNLTATLIV--NVKPQIYEKAVSSFPDPALYPLGSRQILTCTAYGIPQPTIKWF 467
+ + ++V N++P KAV + L C A G+P P + WF
Sbjct: 682 ESKREVALKVLVPPNIEPGPVNKAVLE---------NASVTLECLASGVPPPDVSWF 729
Score = 35.0 bits (79), Expect = 0.23
Identities = 24/86 (27%), Positives = 41/86 (47%), Gaps = 9/86 (10%)
Query: 509 MAIIEGKNKMASTLVVADSRISGIYICIASNKVGTVGRNISFYITDVP----NGFHVNLE 564
+A++E + +++ ADS G Y C A+N+VG+ R + P +G N+
Sbjct: 51 VAVLEEGSLFLASVSPADS---GDYECQATNEVGSTSRRAKLVVYVPPSIREDGRKANVS 107
Query: 565 KMPTEGEDLKLSCTVNKFLYRDVTWI 590
M G+ L L C N F ++ W+
Sbjct: 108 GM--AGQSLTLECDANGFPVPEIVWL 131
Score = 33.9 bits (76), Expect = 0.52
Identities = 23/68 (33%), Positives = 30/68 (44%), Gaps = 2/68 (2%)
Query: 305 DKGLYTCRVRSGPSFKSVNTSVHIYDKAFITVKHRKQQVLETVAGKRSYRLSMKVKAFPS 364
D G Y C+ + S + +Y I RK V +AG+ S L FP
Sbjct: 68 DSGDYECQATNEVGSTSRRAKLVVYVPPSIREDGRKANV-SGMAGQ-SLTLECDANGFPV 125
Query: 365 PEVVWLKD 372
PE+VWLKD
Sbjct: 126 PEIVWLKD 133
Score = 32.7 bits (73), Expect = 1.1
Identities = 31/109 (28%), Positives = 44/109 (40%), Gaps = 13/109 (11%)
Query: 363 PSPEVVWLKDGLPATEK-----SARYLTRGYSLIIKDVTEEDAGNYTILLSIKQSNVFKN 417
P P+V W K P++E L G SL + V+ D+G+Y + + + +
Sbjct: 30 PKPQVTWRKG--PSSEPLHGQPGVAVLEEG-SLFLASVSPADSGDYECQATNEVGSTSRR 86
Query: 418 LTATLIVNVKPQIYEKAVSSFPDPALYPLGSRQILTCTAYGIPQPTIKW 466
A L+V V P I E + G L C A G P P I W
Sbjct: 87 --AKLVVYVPPSIREDGRKANVSGMA---GQSLTLECDANGFPVPEIVW 130
Score = 30.8 bits (68), Expect = 4.4
Identities = 34/137 (24%), Positives = 54/137 (39%), Gaps = 12/137 (8%)
Query: 296 LTIDKMQNKDKGLYTCRVRSGPSFKSVNTSVHIYDKAFITVKHRKQQVLETVAGKRSYRL 355
LTI + + D G Y C + + + V+ + TV L
Sbjct: 3082 LTIHRTERDDAGRYQCLAENEMGVAKKVVILVLQSAPVFQVEPQDM----TVRSGDDVAL 3137
Query: 356 SMKVKAFPSPEVVWLKDGLP-ATEKSARYLTRGYSLIIKDVTEEDAGNYTILLSIKQSNV 414
+ P+P + WL+ G P + R L G SL +++V DAG Y + N+
Sbjct: 3138 RCQATGEPTPTIEWLQAGQPLRASRRLRTLPDG-SLWLENVETGDAGTYDCV----AHNL 3192
Query: 415 FKNLTAT--LIVNVKPQ 429
+ TA L+V +PQ
Sbjct: 3193 LGSATARAFLVVRGEPQ 3209
>gi|239749684 PREDICTED: hemicentin 2 [Homo sapiens]
Length = 5065
Score = 71.6 bits (174), Expect = 2e-12
Identities = 84/324 (25%), Positives = 125/324 (38%), Gaps = 37/324 (11%)
Query: 149 TEGRELVIPCRVT-SPNITVTLKKFPLDTLIPDGKRIIWDSRKGFIISNATYKEIGLLTC 207
TEG +PC+ SP +T K +GK I S + ++ N ++ G TC
Sbjct: 4050 TEGSHAFLPCKARGSPEPNITWDKDGQPVSGAEGKFTIQPSGE-LLVKNLEGQDAGTYTC 4108
Query: 208 EA-TVNGHLYKTNYLTHRQTNTIIDVQISTPRPVKLLRGHTLVLNCTATTPLNTRVQMTW 266
A G + +LT ++ V + P L G L L C A R+ T
Sbjct: 4109 TAENAVGRARRRVHLTI----LVLPVFTTLPGDRSLRLGDRLWLRCAARGSPTPRIGWT- 4163
Query: 267 SYPDEKNKRASVRRRIDQSNSHANIFYSVLTIDKMQNKDKGLYTCRVRSGPSFKSVNTSV 326
N R +Q S L + +D G Y C + + V
Sbjct: 4164 -----VNDRPVTEGVSEQDGG------STLQRAAVSREDSGTYVCWAENRVGRTQAVSFV 4212
Query: 327 HIYDKAFITVKHRKQQVLETVAGKRSYRLSMKVKAFPSPEVVWLKDGLPATEKSARYLTR 386
H+ + A + ++E V G S +L V+ P P++ W+KDGLP R+ +
Sbjct: 4213 HVKE-APVLQGEAFSYLVEPVGG--SIQLDCVVRGDPVPDIHWIKDGLPLRGSHLRHQLQ 4269
Query: 387 GYSLIIKDVTEEDAGNYTIL----LSIKQSNVFKNLTATLIVNVKPQIYEKAVSSFPDPA 442
SL I +DAG Y L + + + V L + + V+PQ + V S D A
Sbjct: 4270 NGSLTIHRTERDDAGRYQCLAENEMGVAKKVVILVLQSAPVFQVEPQ--DMTVRSGDDVA 4327
Query: 443 LYPLGSRQILTCTAYGIPQPTIKW 466
L C A G P PTI+W
Sbjct: 4328 ---------LRCQATGEPTPTIEW 4342
Score = 70.5 bits (171), Expect = 5e-12
Identities = 83/339 (24%), Positives = 125/339 (36%), Gaps = 65/339 (19%)
Query: 307 GLYTCRVRSGPSFKSVNTSVHIYDKAFITVKHRK-----QQVLETVAGKRSYRLSMKVKA 361
G YTC R N++ + F+TV+ V+ VA + L +
Sbjct: 3923 GRYTCSAR--------NSAGVAHKHVFLTVQASPVVKPLPSVVRAVA-EEEVLLPCEASG 3973
Query: 362 FPSPEVVWLKDGLPATEKSARYLTRGYSLIIKDVTEEDAGNYTILLSIKQSNVFKNLTAT 421
P P + W K+GL + + G L I + EDAGNY L I +++ + T
Sbjct: 3974 IPRPTITWQKEGLNVATGVSTQVLPGGQLRIAHASPEDAGNY---LCIAKNSAGSAMGKT 4030
Query: 422 LIVNVKPQIYEKAVSSFPDPALYPLGSRQILTCTAYGIPQPTIKWFWHPCNHNHSEARCD 481
+V P + E + PD + GS L C A G P+P I W
Sbjct: 4031 RLVVQVPPVIE---NGLPDLSTTE-GSHAFLPCKARGSPEPNITW--------------- 4071
Query: 482 FCSNNEESFILDADSNMGNRIESITQRMAIIEGKNKMASTLVVADSRISGIYICIASNKV 541
D D G + + I + L + + +G Y C A N V
Sbjct: 4072 -----------DKD---GQPVSGAEGKFTIQPSGELLVKNL---EGQDAGTYTCTAENAV 4114
Query: 542 GTVGRNISFYITDVPNGFHVNLEKMPTEGEDLKLSCTVNKFLYRDVTWILLRTVNNRTMH 601
G R + I +P + ++ G+ L L C + W TVN+R +
Sbjct: 4115 GRARRRVHLTILVLPVFTTLPGDRSLRLGDRLWLRCAARGSPTPRIGW----TVNDRPVT 4170
Query: 602 YSISKQKMAITKEHSITLNLTIMNVSLQDSGTYACRARN 640
+S+Q T + + VS +DSGTY C A N
Sbjct: 4171 EGVSEQDGGSTLQRAA--------VSREDSGTYVCWAEN 4201
Score = 65.5 bits (158), Expect = 2e-10
Identities = 84/352 (23%), Positives = 124/352 (35%), Gaps = 57/352 (16%)
Query: 296 LTIDKMQNKDKGLYTCRV--RSGPSFKSVNTSVHIYDKAFITVKHRKQQVLETVAGKRSY 353
L + + + D G+YTC +G K V SV + AF Q + G ++
Sbjct: 2993 LQLGRARLSDSGMYTCEALNAAGRDQKLVQLSV-LVPPAFRQAPRGPQDAVLVRVGDKAV 3051
Query: 354 RLSMKVKAFPSPEVVWLKDGLPAT-EKSARYLTRGYSLIIKDVTEEDAGNYTILLSIKQS 412
LS + A P P V W KDG P + + L G L I++ D G Y S K S
Sbjct: 3052 -LSCETDALPEPTVTWYKDGQPLVLAQRTQALRGGQRLEIQEAQVSDKGLY----SCKVS 3106
Query: 413 NVFKNL--TATLIVNVKPQIYEKAVSSFPDPALYPLGSRQILTCTAYGIPQPTIKWFWHP 470
NV T TL V V P + A GS +LTC G+P PT+ W
Sbjct: 3107 NVAGEAVRTFTLTVQVPPTFENPKTETVSQVA----GSPLVLTCDVSGVPAPTVTWL--- 3159
Query: 471 CNHNHSEARCDFCSNNEESFILDADSNMGNRIESITQRMAIIEGKNKMASTLVVADSRIS 530
+ES + G S L A +
Sbjct: 3160 --------------------------KDRMPVESSAVHGVVSRGGRLQLSRLQPAQ---A 3190
Query: 531 GIYICIASNKVGTVGRNISFYITDVP--NGFHVNLEKMPTEGEDLKLSCTVNKFLYRDVT 588
G Y C+A N ++ + P V E EG++++L C + DV
Sbjct: 3191 GTYTCVAENTQAEARKDFVVAVLVAPRIRSSGVAREHHVLEGQEVRLDCEADGQPPPDVA 3250
Query: 589 WILLRTVNNRTMHYSISKQKMAITKEHSITLNLTIMNVSLQDSGTYACRARN 640
W+ + + M + + + +L + + D+G Y C A N
Sbjct: 3251 WLKDGSPLGQDMGPHL--------RFYLDGGSLVLKGLRASDAGAYTCVAHN 3294
Score = 63.5 bits (153), Expect = 6e-10
Identities = 83/365 (22%), Positives = 131/365 (35%), Gaps = 71/365 (19%)
Query: 296 LTIDKMQNKDKGLYTCRVRSGPSFKSVNTSVHIYDKAFITVKHRKQQVLETVAGKRSYRL 355
L I K+Q D G++TC S N ++ + + + V+ V L
Sbjct: 3369 LRISKVQLADAGIFTCVAASPAGVADRNFTLQVQVPPVLEPVEFQNDVV--VVRGSLVEL 3426
Query: 356 SMKVKAFPSPEVVWLKDGLPATEKSARYLTRGYSLIIKDVTEEDAGNYTILLSIKQSNVF 415
+ + P P V W+KDG P +S L +G SL ++ V D+G Y+ + +
Sbjct: 3427 PCEARGVPLPLVSWMKDGEPLLSQS---LEQGPSLQLEAVGAGDSGTYSCVAVSEAGEAR 3483
Query: 416 KNLTATLIVNVKPQIYEKAVSSFPDPALYPLGSRQILTCTAYGIPQPTIKWFWHPCNHNH 475
++ T++ P I + S P G+ L C A G PQP I W H
Sbjct: 3484 RHFQLTVME--PPHIED---SGQPTELSLTPGAPMELLCDAQGTPQPNITW--------H 3530
Query: 476 SEARCDFCSNNEESFILDADSNMGNRIESITQRMAIIEGKNKMASTLVVADSRISGIYIC 535
+ Q + +E ++ L V D +G+Y C
Sbjct: 3531 KDG----------------------------QALTRLENNSRATRVLRVRD---AGLYTC 3559
Query: 536 IASNKVGTVGRNISFYITDVPN-------GFHVNLEKMPTEGEDLKLSCTVNKFLYRDVT 588
+A + G + ++ + PN F V L L L C+V +T
Sbjct: 3560 LAESPAGAIEKSFRVRVQAPPNIVGPRGPRFVVGLAP-----GQLVLECSVEAEPAPKIT 3614
Query: 589 WILLRTVNNRTMHYSISKQKMAITKEHSITLNLTIMNVSLQDSGTYACRARNVYTGEEIL 648
W I Q+ A T+ L + +S DSG Y+C ARN +
Sbjct: 3615 W----------HRDGIVLQEDAHTQFPERGRFLQLQALSTADSGDYSCTARNAAGSTSVA 3664
Query: 649 QKKEI 653
+ EI
Sbjct: 3665 FRVEI 3669
Score = 61.6 bits (148), Expect = 2e-09
Identities = 97/399 (24%), Positives = 143/399 (35%), Gaps = 79/399 (19%)
Query: 248 LVLNCTATTPLNTRVQMTWSYPDEKNKRASVRRRIDQSNSHANIFYSVLTIDKMQNKDKG 307
L+++C+ + L R+Q+ R R +S N + +L K + +G
Sbjct: 444 LLVSCSVHSALPFRLQLR-----RGEARLGEERHFQESG---NSSWEILRASKAE---EG 492
Query: 308 LYTCRVRSGPSFKSVNTSVHIYDKAFITVKHRKQQVLE----TVAGKRSYRLSMKVKAFP 363
Y C S KA I V Q++ TV+ + LS +V
Sbjct: 493 TYECTAVSRAGTGRA--------KAQIVVTDPPPQLVPAPNVTVSPGETAVLSCRVLGEA 544
Query: 364 SPEVVWLKDG--LPATEKSARYLTRGYSLIIKDVTEEDAGNYTILLSIKQSNVFKNLTAT 421
+ W++D LPA+ L SL I + D G Y + S +N +
Sbjct: 545 PYNLTWVRDWRVLPASTGRVAQLA-DLSLEISGIIPTDGGRYQCVAS--NANGVTRASVW 601
Query: 422 LIVNVKPQIYEKAVSSFPDPALYPLGSRQILTCTAYGIPQPTIKWFWHPCNHNHSEARCD 481
L+V PQ VS + G ++C+A G P P I W
Sbjct: 602 LLVREAPQ-----VSIHTSSQHFSQGVEVKVSCSASGYPTPHISW--------------- 641
Query: 482 FCSNNEESFILDADSNMGNRIESITQRMAIIEGKNKMASTLVVADSRISGIYICIASNKV 541
+ ES L DS RI Q II+G +G Y C A+N+V
Sbjct: 642 ----SRESQALQEDS----RIHVDAQGTLIIQG----------VAPEDAGNYSCQATNEV 683
Query: 542 GTVGRNISFYITDVPNGFHVNLEKMPTEGEDLKLSCTVNKFLYRDVTWILLRTVNNRTMH 601
GT ++ Y TD P+ VN + GE+ L C + V W
Sbjct: 684 GTDQETVTLYYTDPPSVSAVNAVVLVAVGEEAVLVCEASGVPPPRVIWYR---------- 733
Query: 602 YSISKQKMAITKEHSITLNLTIMNVSLQDSGTYACRARN 640
+M + E S + L I +D+GTY CRA N
Sbjct: 734 ---GGLEMILAPEGSSSGKLRIPAAQERDAGTYTCRAVN 769
Score = 61.2 bits (147), Expect = 3e-09
Identities = 116/594 (19%), Positives = 215/594 (36%), Gaps = 125/594 (21%)
Query: 91 TLTLNTAQANHTGFYSCKYLAVPTSKKKETESAIYIFISDTGRPFVEMYSEIPEIIHMTE 150
+L + AQA HTG YSC +A + + E + + + + E+ ++ + ++T
Sbjct: 2313 SLHVERAQAAHTGRYSC--VAENLAGRAERKFELSVLVPP------ELIGDLDPLTNITA 2364
Query: 151 GRE--LVIPCR---VTSPNITVTLKKFPL----DTLIPDGKRIIWDSRKGFIISNATYKE 201
L + C + P I + P+ DT + G ++ ++ ++
Sbjct: 2365 ALHSPLTLLCEAMGIPPPAIRWFRGEEPVSPGEDTYLLAGGWMLK-------MTQTQEQD 2417
Query: 202 IGLLTCEATVNGHLYKTNYLTHRQTNTIIDVQISTPRPVKLLRGHTLVLNCTATTPLNTR 261
GL +C A+ + N+ I+ + +K+L G T L C T + +
Sbjct: 2418 SGLYSCLASNEAGEARRNFSVEVLVPPSIENE-DLEEVIKVLDGQTAHLMCNVTG--HPQ 2474
Query: 262 VQMTWSYPDEKNKRASVRRRIDQSNSHANIFYSVLTIDKMQNKDKGLYTCRVRS--GPSF 319
++TW R H + +L + + G Y+C + G
Sbjct: 2475 PKLTWFKDGRPLARGDAH--------HISPDGVLLQVLQANLSSAGHYSCIAANAVGEKT 2526
Query: 320 KSVNTSVHIYDKAFITVKHRKQQVLETVAGKRSYRLSMKVKAFPSPEVVWLKDGLP-ATE 378
K SV + + + + TV L + AFPSP + W+KDG P
Sbjct: 2527 KHFQLSVLLAPTILGGAEDSADEEV-TVTVNNPISLICEALAFPSPNITWMKDGAPFEAS 2585
Query: 379 KSARYLTRGYSLIIKDVTEEDAGNYTILLSIKQSNVFKNLTATLIVNVKPQIYEKAVSSF 438
++ + L + L I + +EDAG YT +++ + KN ++ + P I +
Sbjct: 2586 RNIQLLPGTHGLQILNAQKEDAGQYTCVVTNELGEAVKNYHVEVL--IPPSISK------ 2637
Query: 439 PDPALYPLGSRQI---------LTCTAYGIPQPTIKWFWHPCNHNHSEARCDFCSNNEES 489
D L +G +++ L C ++ +P PTI+W+
Sbjct: 2638 -DDPLGEVGVKEVKTKVNSTLTLECESWAVPPPTIRWY---------------------- 2674
Query: 490 FILDADSNMGNRIESITQRMAIIEGKNKMASTLVVADSRISGIYICIASNKVGTVGRNIS 549
G + ++ + EG+ V+D SG Y+C+A+N G ++ +
Sbjct: 2675 -------KDGQPVTPSSRLQVLGEGRLLQIQPTQVSD---SGRYLCVATNVAGEDDQDFN 2724
Query: 550 FYITDVP-----NGFHVNLEKMPTEGE---------------DLKLSCTVNKFLYRDVTW 589
I P F E + E E L C N D+TW
Sbjct: 2725 VLIQVPPMFQKVGDFSAAFEILSREEEARGGVTEYREIVENNPAYLYCDTNAIPPPDLTW 2784
Query: 590 ILLRTVNNRTMHYSISKQKMAITKEHSITLNLTIMNVSL---QDSGTYACRARN 640
Q ++ E S+ ++ + L +++G Y+C+A N
Sbjct: 2785 YR-------------EDQPLSAGDEVSVLQGGRVLQIPLVRAENAGRYSCKASN 2825
Score = 61.2 bits (147), Expect = 3e-09
Identities = 126/589 (21%), Positives = 218/589 (37%), Gaps = 105/589 (17%)
Query: 69 KESERLSITKSACGRNGKQFCSTLTLNTAQANHTGFYSCKYLAVPTSKKKETESAIYIFI 128
K+S+ LS+ + G TL L A+ + +G Y+C+ L +K + ++ +
Sbjct: 2973 KDSQALSLGEEVFLLPGTH---TLQLGRARLSDSGMYTCEALNAAGRDQKLVQLSVLV-- 3027
Query: 129 SDTGRPFVEMYSEIPE-IIHMTEGRELVIPCRVTS-PNITVTLKKFPLDTLIPDGKRIIW 186
P P+ + + G + V+ C + P TVT K DG+ ++
Sbjct: 3028 ----PPAFRQAPRGPQDAVLVRVGDKAVLSCETDALPEPTVTWYK--------DGQPLVL 3075
Query: 187 DSRKGFI-------ISNATYKEIGLLTCEAT-VNGHLYKTNYLTHRQTNTIIDVQISTPR 238
R + I A + GL +C+ + V G +T LT + T + + T
Sbjct: 3076 AQRTQALRGGQRLEIQEAQVSDKGLYSCKVSNVAGEAVRTFTLTVQVPPTFENPKTET-- 3133
Query: 239 PVKLLRGHTLVLNCTAT-TPLNTRVQMTWSYPDEKNKRASVRRRIDQSNSHANIFYSVLT 297
V + G LVL C + P T +TW + ++V + + L
Sbjct: 3134 -VSQVAGSPLVLTCDVSGVPAPT---VTWLKDRMPVESSAVHGVVSRGGR--------LQ 3181
Query: 298 IDKMQNKDKGLYTCRVRS--GPSFKSVNTSVHIYDKAFITVKHRKQQVLETVAGKRSYRL 355
+ ++Q G YTC + + K +V + + + R+ VLE + RL
Sbjct: 3182 LSRLQPAQAGTYTCVAENTQAEARKDFVVAVLVAPRIRSSGVAREHHVLEG----QEVRL 3237
Query: 356 SMKVKAFPSPEVVWLKDGLPATEKSA---RYLTRGYSLIIKDVTEEDAGNYTILLSIKQS 412
+ P P+V WLKDG P + R+ G SL++K + DAG YT +
Sbjct: 3238 DCEADGQPPPDVAWLKDGSPLGQDMGPHLRFYLDGGSLVLKGLRASDAGAYTCVAHNPAG 3297
Query: 413 NVFKNLTATLIVNVKPQIYEKAVSSFPDPALYPLGSRQILTCTAYGIPQPTIKWFWHPCN 472
+ T ++ V P I + A S + G + C G P + W
Sbjct: 3298 EDARLHTVNVL--VPPTIKQGADGS--GTLVSRPGELVTMVCPVRGSPPIHVSWL----- 3348
Query: 473 HNHSEARCDFCSNNEESFILDADSNMGNRIESITQRMAII-EGKNKMASTLVVADSRISG 531
++ L ++QR + G S + +AD +G
Sbjct: 3349 --------------KDGLPL-----------PLSQRTLLHGSGHTLRISKVQLAD---AG 3380
Query: 532 IYICIASNKVGTVGRNISFYITDVPNGFHVNLEK--MPTEGEDLKLSCTVNKFLYRDVTW 589
I+ C+A++ G RN + + P V + + G ++L C V+W
Sbjct: 3381 IFTCVAASPAGVADRNFTLQVQVPPVLEPVEFQNDVVVVRGSLVELPCEARGVPLPLVSW 3440
Query: 590 ILLRTVNNRTMHYSISKQKMAITKEHSITLNLTIMNVSLQDSGTYACRA 638
+ + ++ + E +L L V DSGTY+C A
Sbjct: 3441 M------------KDGEPLLSQSLEQGPSLQLEA--VGAGDSGTYSCVA 3475
Score = 60.8 bits (146), Expect = 4e-09
Identities = 66/338 (19%), Positives = 120/338 (35%), Gaps = 50/338 (14%)
Query: 305 DKGLYTCRVRSGPSFKSVNTSVHIYDKAFITVKHRKQQVLETVAGKRSYRLSMKVKAFPS 364
D G Y C + + + + + +++ Q + V K +S +P+
Sbjct: 581 DGGRYQCVASNANGVTRASVWLLVREAPQVSIHTSSQHFSQGVEVK----VSCSASGYPT 636
Query: 365 PEVVWLKDGLPATEKSARYLTRGYSLIIKDVTEEDAGNYTILLSIKQSNVFKNLTATLIV 424
P + W ++ E S ++ +LII+ V EDAGNY+ + + T TL
Sbjct: 637 PHISWSRESQALQEDSRIHVDAQGTLIIQGVAPEDAGNYSCQATNEVGT--DQETVTLYY 694
Query: 425 NVKPQIYEKAVSSFPDPALYPLGSRQILTCTAYGIPQPTIKWFWHPCNHNHSEARCDFCS 484
P +VS+ L +G +L C A G+P P + W+
Sbjct: 695 TDPP-----SVSAVNAVVLVAVGEEAVLVCEASGVPPPRVIWY----------------- 732
Query: 485 NNEESFILDADSNMGNRIESITQRMAIIEGKNKMASTLVVADSRISGIYICIASNKVGTV 544
+ + EG + + A R +G Y C A N++G
Sbjct: 733 ------------------RGGLEMILAPEGSSSGKLRIPAAQERDAGTYTCRAVNELGDA 774
Query: 545 GRNISFYITDVPNGFHVNLEKMPTEGEDLKLSCTVNKFLYRDVTWILLRTVNNRTMHYSI 604
I + P + + G L+C VTW R + + + +
Sbjct: 775 SAEIQLAVGHAPQLTELPRDVTVELGRSALLACRATGRPPPTVTW---RRGDGQPLGLRL 831
Query: 605 SKQKMAITKEHSITLNLTIMNVSLQDSGTYACRARNVY 642
+ + +++ + L +V+ +D Y C ARNV+
Sbjct: 832 GAGRGSRSRQPDSGV-LFFESVAPEDQAPYVCEARNVF 868
Score = 59.3 bits (142), Expect = 1e-08
Identities = 48/172 (27%), Positives = 75/172 (43%), Gaps = 7/172 (4%)
Query: 296 LTIDKMQNKDKGLYTCRVRSGPSFKSVNTSVHIYDKAFITVKHRKQQVLETVAGKRSYRL 355
L + + Q+ D G+YTC+ + T + +Y I + V++ VAG R L
Sbjct: 1558 LQLGRAQSSDAGVYTCKASNAVGAAEKATRLDVYVPPTIEGAGGRPYVVKAVAG-RPVAL 1616
Query: 356 SMKVKAFPSPEVVWLKDGLPATEKS-ARYLTRGYSLIIKDVTEEDAGNYTILLSIKQSNV 414
+ PSP + W +GLP E + +R T G L ++ E +G Y+ + S
Sbjct: 1617 ECVARGHPSPTLSWHHEGLPVAESNESRLETDGSVLRLESPGEASSGLYSCVASSPAGEA 1676
Query: 415 FKNLTATLIVNVKPQIYEKAVSSFPDPALYPLGSRQILTCTAYGIPQPTIKW 466
L ++ V V PQ+ V+ +G L C A G P PTI+W
Sbjct: 1677 V--LQYSVEVQVPPQL---LVAEGLGQVTTIVGQPLELPCQASGSPVPTIQW 1723
Score = 58.9 bits (141), Expect = 1e-08
Identities = 79/364 (21%), Positives = 134/364 (36%), Gaps = 66/364 (18%)
Query: 288 HANIFYSVLTIDKMQNKDKGLYTCRVRS--GPSFKSVNTSVHIYDKAFITVKHRKQQVLE 345
H + +L + + Q +G YTC + G S + + VH+ + R+
Sbjct: 2212 HVSAVGRLLYLGQAQLAQEGTYTCECSNVVGNSSQDLQLEVHVPPQI---AGPREPPTQV 2268
Query: 346 TVAGKRSYRLSMKVKAFPSPEVVWLKDGLPA-TEKSARYLTRGYSLIIKDVTEEDAGNYT 404
+V L P P V W +DG P E + +G SL ++ G Y+
Sbjct: 2269 SVVQDGVATLECNATGKPPPTVTWERDGQPVGAELGLQLQNQGQSLHVERAQAAHTGRYS 2328
Query: 405 ILLSIKQSNVFKNLTATLIVNVKPQIYEKAVSSFPDPALY---PLGSRQILTCTAYGIPQ 461
+ + +++V P++ DP L S L C A GIP
Sbjct: 2329 CVAENLAGRAERKFELSVLV--PPELIGDL-----DPLTNITAALHSPLTLLCEAMGIPP 2381
Query: 462 PTIKWFWHPCNHNHSEARCDFCSNNEESFILDADSNMGNRIESITQRMAIIEGKNKMAST 521
P I+WF + S E++++L G + +TQ
Sbjct: 2382 PAIRWFRGE----------EPVSPGEDTYLL-----AGGWMLKMTQ-------------- 2412
Query: 522 LVVADSRISGIYICIASNKVGTVGRNISFYITDVPNGFHVNLEKM--PTEGEDLKLSCTV 579
+ SG+Y C+ASN+ G RN S + P+ + +LE++ +G+ L C V
Sbjct: 2413 ---TQEQDSGLYSCLASNEAGEARRNFSVEVLVPPSIENEDLEEVIKVLDGQTAHLMCNV 2469
Query: 580 NKFLYRDVTWILLRTVNNRTMHYSISKQKMAITKEHSIT---LNLTIMNVSLQDSGTYAC 636
+TW + +A H I+ + L ++ +L +G Y+C
Sbjct: 2470 TGHPQPKLTWFK-------------DGRPLARGDAHHISPDGVLLQVLQANLSSAGHYSC 2516
Query: 637 RARN 640
A N
Sbjct: 2517 IAAN 2520
Score = 58.5 bits (140), Expect = 2e-08
Identities = 95/449 (21%), Positives = 164/449 (36%), Gaps = 61/449 (13%)
Query: 32 PELSLKGTQHIMQAGQTLHLQCRGEAAH----KWSLPEMVSKESERLSITKSACGRNGKQ 87
P++S+ + G + + C WS +E R+ +
Sbjct: 608 PQVSIHTSSQHFSQGVEVKVSCSASGYPTPHISWSRESQALQEDSRIHVDAQG------- 660
Query: 88 FCSTLTLNTAQANHTGFYSCKYLAVPTSKKKETESAIYIFISDTGRPFVEMYSEIPEIIH 147
TL + G YSC+ T++ + + ++ +D P V S + ++
Sbjct: 661 ---TLIIQGVAPEDAGNYSCQ----ATNEVGTDQETVTLYYTDP--PSV---SAVNAVVL 708
Query: 148 MTEGRELVIPCRVTS-PNITVTLKKFPLDTLI-PDGKRIIWDSRKGFIISNATYKEIGLL 205
+ G E V+ C + P V + L+ ++ P+G S I A ++ G
Sbjct: 709 VAVGEEAVLVCEASGVPPPRVIWYRGGLEMILAPEGS-----SSGKLRIPAAQERDAGTY 763
Query: 206 TCEATVN-GHLYKTNYLTHRQTNTIIDVQISTPRPVKLLRGHTLVLNCTAT-TPLNTRVQ 263
TC A G L + ++ PR V + G + +L C AT P T
Sbjct: 764 TCRAVNELGDASAEIQLAVGHAPQLTEL----PRDVTVELGRSALLACRATGRPPPT--- 816
Query: 264 MTWSYPDEKNKRASVRRRIDQSNSHANIFYSVLTIDKMQNKDKGLYTCRVRSGPSFKSVN 323
+TW D + +R + + VL + + +D+ Y C R+ F V
Sbjct: 817 VTWRRGD--GQPLGLRLGAGRGSRSRQPDSGVLFFESVAPEDQAPYVCEARN--VFGKVQ 872
Query: 324 TSVHIYDKAFITVKHRKQQV------LETVAGKRSYRLSMKVKAFPSPEVVWLKDGLPAT 377
+ I H Q+ + + G+ + + P PE WLKDG P
Sbjct: 873 AEARL-----IVTGHAPPQIASSAPTVRVLEGQPVSLPCIVLAGRPLPERHWLKDGRPLP 927
Query: 378 EKSARYLTRGYSLIIKDVTEEDAGNYTILLSIKQSNVFKNLTATLIVNVKPQIYEKAVSS 437
S + SL + +E AG Y+ + + + +++ L+V V P+I+ A
Sbjct: 928 PGSRHSIRADGSLHLDRALQEHAGRYSCVATNTAGSQHRDV--ELVVQVPPRIHPTATHH 985
Query: 438 FPDPALYPLGSRQILTCTAYGIPQPTIKW 466
+ G L C A G+P PTI W
Sbjct: 986 ITNE-----GVPASLPCVASGVPAPTITW 1009
Score = 58.5 bits (140), Expect = 2e-08
Identities = 112/564 (19%), Positives = 207/564 (36%), Gaps = 106/564 (18%)
Query: 92 LTLNTAQANHTGFYSCKYLAVPTSKKKETESAIYIFISDTGRPFVEMYSEIPEIIHMTEG 151
L + A H G Y+C +++ + ++F++ P V+ +P ++
Sbjct: 3912 LEIGQALPIHAGRYTC------SARNSAGVAHKHVFLTVQASPVVK---PLPSVVRAVAE 3962
Query: 152 RELVIPCRVTS-PNITVTLKKFPLDTLIPDGKRIIWDSRKGFIISNATYKEIGLLTCEA- 209
E+++PC + P T+T +K L+ +++ + I++A+ ++ G C A
Sbjct: 3963 EEVLLPCEASGIPRPTITWQKEGLNVATGVSTQVLPGGQ--LRIAHASPEDAGNYLCIAK 4020
Query: 210 -TVNGHLYKTNYLTHRQTNTIIDVQISTPRPVKLLRGHTLVLNCTATTPLNTRVQMTWSY 268
+ + KT + Q +I+ + + G L C A + +TW
Sbjct: 4021 NSAGSAMGKTRLVV--QVPPVIENGLPD---LSTTEGSHAFLPCKARG--SPEPNITWDK 4073
Query: 269 PDEKNKRASVRRRIDQSNSHANIFYSVLTIDKMQNKDKGLYTCRVRS--GPSFKSVNTSV 326
+ A + I S L + ++ +D G YTC + G + + V+ ++
Sbjct: 4074 DGQPVSGAEGKFTIQPSGE--------LLVKNLEGQDAGTYTCTAENAVGRARRRVHLTI 4125
Query: 327 HIYDKAFITVKHRKQQVLETVAGKRSYRLSMKV------KAFPSPEVVWLKDGLPATEKS 380
+ V T+ G RS RL ++ + P+P + W + P TE
Sbjct: 4126 LVLP------------VFTTLPGDRSLRLGDRLWLRCAARGSPTPRIGWTVNDRPVTEGV 4173
Query: 381 ARYLTRGYSLIIKDVTEEDAGNYTILLSIKQSNVFKNLTATLIVNVK--PQIYEKAVSSF 438
+ G +L V+ ED+G Y N A V+VK P + +A S
Sbjct: 4174 SEQ-DGGSTLQRAAVSREDSGTYVCWAE----NRVGRTQAVSFVHVKEAPVLQGEAFSYL 4228
Query: 439 PDPALYPLGSRQILTCTAYGIPQPTIKWFWHPCNHNHSEARCDFCSNNEESFILDADSNM 498
+P +G L C G P P I W I D
Sbjct: 4229 VEP----VGGSIQLDCVVRGDPVPDIHW------------------------IKDGLPLR 4260
Query: 499 GNRIESITQRMAIIEGKNKMASTLVVADSRISGIYICIASNKVGTVGRNISFYITDVPNG 558
G+ + Q ++ T+ + +G Y C+A N++G + + + P
Sbjct: 4261 GSHLRHQLQNGSL---------TIHRTERDDAGRYQCLAENEMGVAKKVVILVLQSAPV- 4310
Query: 559 FHVNLEKMPTE-GEDLKLSCTVNKFLYRDVTWILLRTVNNRTMHYSISKQKMAITKEHSI 617
F V + M G+D+ L C + W+ + + +++ + S+
Sbjct: 4311 FQVEPQDMTVRSGDDVALRCQATGEPTPTIEWL-------QAGQPLRASRRLRTLPDGSL 4363
Query: 618 TLNLTIMNVSLQDSGTYACRARNV 641
L NV D+GTY C A N+
Sbjct: 4364 WLE----NVETGDAGTYDCVAHNL 4383
Score = 57.0 bits (136), Expect = 6e-08
Identities = 132/599 (22%), Positives = 209/599 (34%), Gaps = 109/599 (18%)
Query: 94 LNTAQAN--HTGFYSCKYLAVPTSKKKETESAIYIFISDTGRPFVEMYSEIPEIIHMTEG 151
L QAN G YSC +A +K + + ++ T E ++ E + +T
Sbjct: 2501 LQVLQANLSSAGHYSC--IAANAVGEKTKHFQLSVLLAPTILGGAEDSAD--EEVTVTVN 2556
Query: 152 RELVIPCRVT---SPNITVTLKKFPLDTLIPDGKRI-IWDSRKGFIISNATYKEIGLLTC 207
+ + C SPNIT P + + I + G I NA ++ G TC
Sbjct: 2557 NPISLICEALAFPSPNITWMKDGAPFEA----SRNIQLLPGTHGLQILNAQKEDAGQYTC 2612
Query: 208 EATVNGHLYKTNYLTHRQTNTIIDVQISTPRP--------VKLLRGHTLVLNCT--ATTP 257
T NY +I IS P VK TL L C A P
Sbjct: 2613 VVTNELGEAVKNY----HVEVLIPPSISKDDPLGEVGVKEVKTKVNSTLTLECESWAVPP 2668
Query: 258 LNTRVQMTWSYPDEKNKRASVRRRIDQSNSHANIFYSVLTIDKMQNKDKGLYTCRVRS-- 315
R W Y D + S R ++ +L I Q D G Y C +
Sbjct: 2669 PTIR----W-YKDGQPVTPSSRLQVLGEGR-------LLQIQPTQVSDSGRYLCVATNVA 2716
Query: 316 GPSFKSVNTSVHI---------YDKAFITVKHRKQ------QVLETVAGKRSYRLSMKVK 360
G + N + + + AF + ++ + E V +Y L
Sbjct: 2717 GEDDQDFNVLIQVPPMFQKVGDFSAAFEILSREEEARGGVTEYREIVENNPAY-LYCDTN 2775
Query: 361 AFPSPEVVWLKDGLPATE-KSARYLTRGYSLIIKDVTEEDAGNYTILLSIKQSN-VFKNL 418
A P P++ W ++ P + L G L I V E+AG Y S K SN V ++
Sbjct: 2776 AIPPPDLTWYREDQPLSAGDEVSVLQGGRVLQIPLVRAENAGRY----SCKASNEVGEDW 2831
Query: 419 TATLIVNVKPQIYEKAVSSFPDPALYPLGSRQILTCTAYGIPQPTIKWFWHPCNHNHSEA 478
++ + P + + S L C A G P PTI W
Sbjct: 2832 LHYELLVLTPPVILGDTEELVEEVTVNASSTVSLQCPALGNPVPTISWL----------- 2880
Query: 479 RCDFCSNNEESFILDADSNMGNRIESITQRMAIIE-GKNKMASTLVVADSRISGIYICIA 537
N F S + R+ ++E G+ ST VAD+ Y+C+A
Sbjct: 2881 ------QNGLPF-------------SPSPRLQVLEDGQVLQVSTAEVADA---ASYMCVA 2918
Query: 538 SNKVGTVGRNISFYITDVPNGFHVNLEKMPTE-GEDLKLSCTVNKFLYRDVTWILLRTVN 596
N+ G+ + + + P ++LE++ + L C V+ +VTW
Sbjct: 2919 ENQAGSAEKLFTLRVQVPPRIAGLDLEQVTAILNSSVSLPCDVHAHPNPEVTWY------ 2972
Query: 597 NRTMHYSISKQKMAITKEHSITLNLTIMNVSLQDSGTYACRARNVYTGEEILQKKEITI 655
+ S+ ++ + H++ L L DSG Y C A N ++ L + + +
Sbjct: 2973 KDSQALSLGEEVFLLPGTHTLQLG----RARLSDSGMYTCEALNAAGRDQKLVQLSVLV 3027
Score = 56.6 bits (135), Expect = 7e-08
Identities = 65/294 (22%), Positives = 111/294 (37%), Gaps = 53/294 (18%)
Query: 352 SYRLSMKVKAFPSPEVVWLKDGLPATEKSARYLTRG-YSLIIKDVTEEDAGNYTILLSIK 410
S L V A P+PEV W KD + +L G ++L + D+G YT
Sbjct: 2954 SVSLPCDVHAHPNPEVTWYKDSQALSLGEEVFLLPGTHTLQLGRARLSDSGMYTCEALNA 3013
Query: 411 QSNVFKNLTATLIVNVKPQIYEKAVSSFPDPALYPLGSRQILTCTAYGIPQPTIKWFWHP 470
K + +++V P + +A D L +G + +L+C +P+PT+ W+
Sbjct: 3014 AGRDQKLVQLSVLV---PPAFRQAPRGPQDAVLVRVGDKAVLSCETDALPEPTVTWY--- 3067
Query: 471 CNHNHSEARCDFCSNNEESFILDADSNMGNRIESITQRMAIIEGKNKMASTLVVADSRIS 530
+ + +L QR + G + L + ++++S
Sbjct: 3068 --------------KDGQPLVL-------------AQRTQALRGGQR----LEIQEAQVS 3096
Query: 531 --GIYICIASNKVGTVGRNISFYITDVPNGFHVNLEKM-PTEGEDLKLSCTVNKFLYRDV 587
G+Y C SN G R + + P + E + G L L+C V+ V
Sbjct: 3097 DKGLYSCKVSNVAGEAVRTFTLTVQVPPTFENPKTETVSQVAGSPLVLTCDVSGVPAPTV 3156
Query: 588 TWILLR-TVNNRTMHYSISKQKMAITKEHSITLNLTIMNVSLQDSGTYACRARN 640
TW+ R V + +H +S+ L + + +GTY C A N
Sbjct: 3157 TWLKDRMPVESSAVHGVVSRGG-----------RLQLSRLQPAQAGTYTCVAEN 3199
Score = 55.1 bits (131), Expect = 2e-07
Identities = 118/553 (21%), Positives = 191/553 (34%), Gaps = 106/553 (19%)
Query: 108 KYLAVPTSKKKETESAIYIFISDTGRPFVEMYSEIPEIIHMTEGRELVIPCRVT---SPN 164
+Y V ++ T +++++ + + + + S+ H ++G E+ + C + +P+
Sbjct: 584 RYQCVASNANGVTRASVWLLVREAPQVSIHTSSQ-----HFSQGVEVKVSCSASGYPTPH 638
Query: 165 ITVTLKKFPLDTLIPDGKRIIWDSRKGFIISNATYKEIGLLTCEATVNGHLYKTNYLTHR 224
I+ + + L + RI D++ II ++ G +C+AT T +
Sbjct: 639 ISWSRESQALQ----EDSRIHVDAQGTLIIQGVAPEDAGNYSCQAT-------NEVGTDQ 687
Query: 225 QTNTIIDVQ---ISTPRPVKLLR-GHTLVLNCTATTPLNTRVQMTWSYPDEKNKRASVRR 280
+T T+ +S V L+ G VL C A+ RV W R +
Sbjct: 688 ETVTLYYTDPPSVSAVNAVVLVAVGEEAVLVCEASGVPPPRV--IWY-------RGGLEM 738
Query: 281 RIDQSNSHANIFYSVLTIDKMQNKDKGLYTCRVRSGPSFKSVNTSVHIYDKAFITVKHRK 340
+ S + L I Q +D G YTCR + S + + +T R
Sbjct: 739 ILAPEGSSSG----KLRIPAAQERDAGTYTCRAVNELGDASAEIQLAVGHAPQLTELPRD 794
Query: 341 QQVLETVAGKRSYRLSMKVKAFPSPEVVWLK-DGLP------ATEKSARYLTRGYSLIIK 393
TV RS L+ + P P V W + DG P A S L +
Sbjct: 795 V----TVELGRSALLACRATGRPPPTVTWRRGDGQPLGLRLGAGRGSRSRQPDSGVLFFE 850
Query: 394 DVTEEDAGNYTILLSIKQSNVFKNLTATLIVNVKPQIYEKAVSSFPDPALYPLGSRQILT 453
V ED Y + NVF + A + V + SS P + G L
Sbjct: 851 SVAPEDQAPYVC----EARNVFGKVQAEARLIVTGHAPPQIASSAPTVRVLE-GQPVSLP 905
Query: 454 CTAY-GIPQPTIKWFWH----PCNHNHSEARCDFCSNNEESFILDADSNMGNRIESITQR 508
C G P P W P HS + AD ++ ++ Q
Sbjct: 906 CIVLAGRPLPERHWLKDGRPLPPGSRHS---------------IRADGSL--HLDRALQE 948
Query: 509 MAIIEGKNKMASTLVVADSRISGIYICIASNKVGTVGRNISFYITDVPNGFHVNLEKMPT 568
A G Y C+A+N G+ R++ + P +
Sbjct: 949 HA--------------------GRYSCVATNTAGSQHRDVELVVQVPPRIHPTATHHITN 988
Query: 569 EGEDLKLSCTVNKFLYRDVTWIL-LRTVNNRTMHYSISKQKMAITKEHSITLNLTIMNVS 627
EG L C + +TW + +R HY++SK+ L I S
Sbjct: 989 EGVPASLPCVASGVPAPTITWTKETNALTSRGPHYNVSKEG-----------TLLIAQPS 1037
Query: 628 LQDSGTYACRARN 640
QD+G Y C A N
Sbjct: 1038 AQDAGAYVCTATN 1050
Score = 55.1 bits (131), Expect = 2e-07
Identities = 82/351 (23%), Positives = 122/351 (34%), Gaps = 61/351 (17%)
Query: 296 LTIDKMQNKDKGLYTCRVR--SGPSFKSVNTSVHIYDKAFITVKHRKQQVLETVAGKRSY 353
L I+K+ +D+G+YTC +G S + V K + V + V S
Sbjct: 1850 LQIEKVDLRDEGIYTCAATNLAGESKREVAL------KVLVPPNIEPGPVNKAVLENASV 1903
Query: 354 RLSMKVKAFPSPEVVWLKDGLPATE-KSARYLTRGYSLIIKDVTEEDAGNYTILLSIKQS 412
L P P+V W K P + G L I+ DAG+Y + S
Sbjct: 1904 TLECLASGVPPPDVSWFKGHQPVSSWMGVTVSVDGRVLRIEQAQLSDAGSYRCVASNVAG 1963
Query: 413 NVFKNLTATLIVNVKPQIYEKAVSSFPDPALYPLGSRQILTCTAYGIPQPTIKWFWHPCN 472
+ L L VNV P+I S P P L R LTC A G P PT+ W
Sbjct: 1964 ST--ELRYGLRVNVPPRI--TLPPSLPGPVLVNTPVR--LTCNATGAPSPTLMWL----- 2012
Query: 473 HNHSEARCDFCSNNEESFILDADSNMGNRIESI-TQRMAIIEGKNKMASTLVVADSRISG 531
GN + T + + G + TL A + SG
Sbjct: 2013 ------------------------KDGNPVSPAGTPGLQVFPGGRVL--TLASARASDSG 2046
Query: 532 IYICIASNKVGTVGRNISFYITDVPNGFHVNLEKMPTEGEDLKLSCTVNKFLYRDVTWIL 591
Y C+A + VG +++ + P+ L E + L C + ++W
Sbjct: 2047 RYSCVAVSAVGEDRQDVVLQVHMPPSILGEELNVSVVANESVALECQSHAMPPPVLSWWK 2106
Query: 592 -LRTVNNRT-MHYSISKQKMAITKEHSITLNLTIMNVSLQDSGTYACRARN 640
R + R +H S K + + + + D+G Y C A N
Sbjct: 2107 DGRPLEPRPGVHLSADKALLQVDR------------ADVWDAGHYTCEALN 2145
Score = 54.7 bits (130), Expect = 3e-07
Identities = 85/362 (23%), Positives = 134/362 (37%), Gaps = 54/362 (14%)
Query: 237 PRPVKLLRGHTLVLNCTATTPLNTRVQMTWSYPDEKNKRASVRRRIDQSNSHANIFYSVL 296
PR +K+L G L LNC A N Q++WS ++ R Q + H F ++
Sbjct: 1126 PRVLKVLVGEALDLNCVAEG--NPEPQLSWS-----KDGVVLQGRGPQGSVH---FAAIR 1175
Query: 297 TIDKMQNKDKGLYTCRVRSGPSFKSVNTSVHIYDKAFITVKHRKQQVLETVAGKRSYRLS 356
T D G Y C + + + + + +LE VAG+ + L
Sbjct: 1176 T------SDAGRYRCEASNSAGVDAWEVELRVLEPPHWGADETSG-LLERVAGENA-SLP 1227
Query: 357 MKVKAFPSPEVVWLKDGLPATEK-----SARYLTRGYSLIIKDVTEEDAGNYTILLSIKQ 411
+ P P+V W K P++E L G SL + V+ D+G+Y + +
Sbjct: 1228 CPARGTPKPQVTWRKG--PSSEPLHGQPGVAVLEEG-SLFLASVSPADSGDYECQATNEV 1284
Query: 412 SNVFKNLTATLIVNVKPQIYEKAVSSFPDPALYPLGSRQILTCTAYGIPQPTIKWFWHPC 471
+ + A L+V V P I E + G L C A G P P I W
Sbjct: 1285 GSTSRR--AKLVVYVPPSIREDGRKANVSGMA---GQSLTLECDANGFPVPEIVWL---- 1335
Query: 472 NHNHSEARCDFCSNNEESFILDADSNM--GNRIESITQRMAIIEGKNKMASTLVVADSRI 529
+A+ + D G+R+ + EG++ + DS
Sbjct: 1336 ----KDAQLVGVPLGWAGYGWDLGWGQVGGHRL--------LDEGQSLHFPRIQEGDS-- 1381
Query: 530 SGIYICIASNKVGTVGRNISFYITDVPN--GFHVNLEKMPTEGEDLKLSCTVNKFLYRDV 587
G+Y C A N+ GT R+ + P+ G E + G D++L C + V
Sbjct: 1382 -GLYSCRAENQAGTAQRDFHLLVLTPPSVLGAGAAQEVLGLAGADVELQCWTSGVPTPQV 1440
Query: 588 TW 589
W
Sbjct: 1441 EW 1442
Score = 53.1 bits (126), Expect = 8e-07
Identities = 110/506 (21%), Positives = 185/506 (36%), Gaps = 85/506 (16%)
Query: 160 VTSPNITVTLKKFPLDTLIPDGKRIIWD-SRKGFIISNATYKEIGLLTCEATVNGHLYKT 218
V +PNIT F L+P ++++ + + A + G+ TC+A+
Sbjct: 1529 VPTPNITW----FKDGALLPTSTKVVYTRGGRQLQLGRAQSSDAGVYTCKAS-------- 1576
Query: 219 NYLTHRQTNTIIDVQI--------STPRPVKLLRGHTLVLNCTATTPLNTRVQMTWSYPD 270
N + + T +DV + P VK + G + L C A T S+
Sbjct: 1577 NAVGAAEKATRLDVYVPPTIEGAGGRPYVVKAVAGRPVALECVA----RGHPSPTLSWHH 1632
Query: 271 EKNKRASVRRRIDQSNSHANIFYSVLTIDKMQNKDKGLYTCRVRSGPSFKSV-NTSVHIY 329
E A + + S SVL ++ GLY+C V S P+ ++V SV +
Sbjct: 1633 EGLPVA------ESNESRLETDGSVLRLESPGEASSGLYSC-VASSPAGEAVLQYSVEVQ 1685
Query: 330 DKAFITVKHRKQQVLETVAGKRSYRLSMKVKAFPSPEVVWLKDGLPATE-KSARYLTRGY 388
+ V QV T+ G+ L + P P + WL++G PA E + ++G
Sbjct: 1686 VPPQLLVAEGLGQVT-TIVGQ-PLELPCQASGSPVPTIQWLQNGRPAEELAGVQVASQGT 1743
Query: 389 SLIIKDVTEEDAGNYTILLSIKQSNVFKNLTATLIVNVKPQIYEKAVSSFPDPALYPLGS 448
+L I V + +G L + + +N A + V+V + P P+G
Sbjct: 1744 TLHIDHVELDHSG----LFACQATNEAGTAGAEVEVSVHGE-------WAPGVLEVPIG- 1791
Query: 449 RQILTCTAYGIPQPTIKWFWHPCNHNHSEARCD-----FCSNNEESFILDADSNMGNRIE 503
++ W +H+ A CD + + +++ + G
Sbjct: 1792 ----------------QYHWGXEHHSSFPAACDPPVHRGWGAHPKPPLVEGWCSPG---- 1831
Query: 504 SITQRMAIIEGKNKMASTLVV--ADSRISGIYICIASNKVGTVGRNISFYITDVPNGFHV 561
S+ I + L + D R GIY C A+N G R ++ + PN
Sbjct: 1832 SLWGEPTGIPVAYSLPPPLQIEKVDLRDEGIYTCAATNLAGESKREVALKVLVPPNIEPG 1891
Query: 562 NLEKMPTEGEDLKLSCTVNKFLYRDVTWILLRTVNNRTMHYSISKQKMAITKEHSITLNL 621
+ K E + L C + DV+W + M ++S L
Sbjct: 1892 PVNKAVLENASVTLECLASGVPPPDVSWFKGHQPVSSWMGVTVSVDGRV----------L 1941
Query: 622 TIMNVSLQDSGTYACRARNVYTGEEI 647
I L D+G+Y C A NV E+
Sbjct: 1942 RIEQAQLSDAGSYRCVASNVAGSTEL 1967
Score = 52.4 bits (124), Expect = 1e-06
Identities = 92/372 (24%), Positives = 136/372 (36%), Gaps = 63/372 (16%)
Query: 295 VLTIDKMQNKDKGLYTCRVRSGPSFKSVNTSVHIYDKAFITVKHRKQQVLETVAGKRSYR 354
VL I D+G Y C S ++ + + ++ I + +V V +
Sbjct: 1464 VLRITGSHVGDEGRYQCVAFSPAGQQARDFQLRVHAPPTIWGSNETGEV--AVMEDHLVQ 1521
Query: 355 LSMKVKAFPSPEVVWLKDG-LPATEKSARYLTRGYSLIIKDVTEEDAGNYTILLSIKQSN 413
L + + P+P + W KDG L T Y G L + DAG YT K SN
Sbjct: 1522 LLCEARGVPTPNITWFKDGALLPTSTKVVYTRGGRQLQLGRAQSSDAGVYT----CKASN 1577
Query: 414 VF--KNLTATLIVNVKPQIYEKAVSSFPDPALYPLGSRQILTCTAYGIPQPTIKWFWHPC 471
L V V P I + P G L C A G P PT+ W
Sbjct: 1578 AVGAAEKATRLDVYVPPTI--EGAGGRPYVVKAVAGRPVALECVARGHPSPTLSW----- 1630
Query: 472 NHNHSEARCDFCSNNEESFILDADSNMGNRIESITQRMAIIEGKNKMASTLVVADSRISG 531
H E +NE L+ D ++ R+ES SG
Sbjct: 1631 ---HHEG-LPVAESNESR--LETDGSV-LRLES--------------------PGEASSG 1663
Query: 532 IYICIASNKVGTVGRNISFYITDVPNGFHV--NLEKMPT-EGEDLKLSCTVNKFLYRDVT 588
+Y C+AS+ G S + VP V L ++ T G+ L+L C + +
Sbjct: 1664 LYSCVASSPAGEAVLQYSVEV-QVPPQLLVAEGLGQVTTIVGQPLELPCQASGSPVPTIQ 1722
Query: 589 WILLRTVNNRTMHYSISKQKMAITKEHSITLNLTIMNVSLQDSGTYACRARNV--YTGEE 646
W+ N R +++A + S L I +V L SG +AC+A N G E
Sbjct: 1723 WL----QNGR------PAEELAGVQVASQGTTLHIDHVELDHSGLFACQATNEAGTAGAE 1772
Query: 647 ILQKKEITIRGE 658
+ E+++ GE
Sbjct: 1773 V----EVSVHGE 1780
Score = 52.0 bits (123), Expect = 2e-06
Identities = 86/382 (22%), Positives = 141/382 (36%), Gaps = 45/382 (11%)
Query: 91 TLTLNTAQANHTGFYSCKYLAVPTSKKKETESAIYIFISDTGRPFVEMYSEIPEIIHMTE 150
+L L A +G YSC V S+ E + + + P +E + P + +T
Sbjct: 3457 SLQLEAVGAGDSGTYSC----VAVSEAGEARRHFQLTVMEP--PHIEDSGQ-PTELSLTP 3509
Query: 151 GRELVIPCRVT-SPNITVTLKKFPLDTLIPDGKRIIWDSRKGFIISNATYKEIGLLTCEA 209
G + + C +P +T K DG+ + ++ GL TC A
Sbjct: 3510 GAPMELLCDAQGTPQPNITWHK--------DGQALTRLENNSRATRVLRVRDAGLYTCLA 3561
Query: 210 TVNGHLYKTNYLTHRQTNTIIDVQISTPRPVKLLRGHTLVLNCTATTPLNTRVQMTWSYP 269
+ ++ Q I V PR V L LVL C+ ++ TW
Sbjct: 3562 ESPAGAIEKSFRVRVQAPPNI-VGPRGPRFVVGLAPGQLVLECSVEAEPAPKI--TWH-- 3616
Query: 270 DEKNKRASVRRRIDQSNSHANIFYS--VLTIDKMQNKDKGLYTCRVRSGPSFKSVNTSVH 327
R + + Q ++H L + + D G Y+C R+ SV V
Sbjct: 3617 -----RDGI---VLQEDAHTQFPERGRFLQLQALSTADSGDYSCTARNAAGSTSVAFRVE 3668
Query: 328 IYDKAFITVKHRKQQVLETVAGKRSYRLSMKVKAFPSPEVVWLKDGLPATEKSARY--LT 385
I+ I R V+ ++ L + P+P V W KD +P +S R+ L
Sbjct: 3669 IHTVPTI----RSGPPAVNVSVNQTALLPCQADGVPAPLVSWRKDRVPLDPRSPRFEILP 3724
Query: 386 RGYSLIIKDVTEEDAGNYTILLSIKQSNVFKNLTATLIVNVKPQIYEKAVSSFPDPALYP 445
G SL I+ V +DAG+Y L S + + + + A++ P
Sbjct: 3725 EG-SLRIQPVLAQDAGHYLCLASNSAGSDRQGRDLRV-------LEPPAIAPSPSNLTLT 3776
Query: 446 LGSRQILTCTAYGIPQPTIKWF 467
+ +L C A G P+P + W+
Sbjct: 3777 AHTPALLPCEASGSPKPLVVWW 3798
Score = 45.4 bits (106), Expect = 2e-04
Identities = 49/184 (26%), Positives = 69/184 (37%), Gaps = 14/184 (7%)
Query: 288 HANIFYSVLTIDKMQNKDKGLYTCRV--RSGPSFKSVNTSVHIYDKAFITVKHRKQQVLE 345
H + ++L +D+ D G YTC ++G S K N +V + + H
Sbjct: 2118 HLSADKALLQVDRADVWDAGHYTCEALNQAGHSEKHYNLNVWVAPVFPLRESHTL----- 2172
Query: 346 TVAGKRSYRLSMKVKAFPSPEVVWLKDGLPATEKSA---RYLTRGYSLIIKDVTEEDAGN 402
TV LS + + P P++ W KDG P + A G L + G
Sbjct: 2173 TVREGHPTSLSCECRGVPFPKISWRKDGQPLPGEGAGLQHVSAVGRLLYLGQAQLAQEGT 2232
Query: 403 YTILLSIKQSNVFKNLTATLIVNVKPQIYEKAVSSFPDPALYPLGSRQILTCTAYGIPQP 462
YT S N ++L L V+V PQI P L C A G P P
Sbjct: 2233 YTCECSNVVGNSSQDL--QLEVHVPPQI--AGPREPPTQVSVVQDGVATLECNATGKPPP 2288
Query: 463 TIKW 466
T+ W
Sbjct: 2289 TVTW 2292
Score = 44.3 bits (103), Expect = 4e-04
Identities = 80/369 (21%), Positives = 135/369 (36%), Gaps = 76/369 (20%)
Query: 295 VLTIDKMQNKDKGLYTCRVRSGPSFKSVNTSVHIYDKAFIT---VKHRKQQVLETVAGKR 351
VL I ++ ++ G Y+C+ + V Y+ +T + ++++E V
Sbjct: 2805 VLQIPLVRAENAGRYSCKASN-----EVGEDWLHYELLVLTPPVILGDTEELVEEVTVNA 2859
Query: 352 SYRLSMKVKAF--PSPEVVWLKDGLP-ATEKSARYLTRGYSLIIKDVTEEDAGNYTILLS 408
S +S++ A P P + WL++GLP + + L G L + DA +Y +
Sbjct: 2860 SSTVSLQCPALGNPVPTISWLQNGLPFSPSPRLQVLEDGQVLQVSTAEVADAASYMCVAE 2919
Query: 409 IKQSNVFKNLTATLIVNVKPQIYEKAVSSFPDPALYPLGSRQILTCTAYGIPQPTIKWFW 468
+ + K T L V V P+I + + L S L C + P P + W+
Sbjct: 2920 NQAGSAEKLFT--LRVQVPPRIAGLDL----EQVTAILNSSVSLPCDVHAHPNPEVTWY- 2972
Query: 469 HPCNHNHSEARCDFCSNNEESFILDADSNMGNRIESITQRMAIIEGKNKMASTLVVADSR 528
S+A S EE F+L TL + +R
Sbjct: 2973 -----KDSQA----LSLGEEVFLLPG------------------------THTLQLGRAR 2999
Query: 529 IS--GIYICIASNKVGTVGRNISFYITDVPNGFHVNLEKMPTE------GEDLKLSCTVN 580
+S G+Y C A N G + + + VP F + P + G+ LSC +
Sbjct: 3000 LSDSGMYTCEALNAAGRDQKLVQLSVL-VPPAFR-QAPRGPQDAVLVRVGDKAVLSCETD 3057
Query: 581 KFLYRDVTWILLRTVNNRTMHYSISKQKMAITKEHSIT--LNLTIMNVSLQDSGTYACRA 638
VTW Y + + + ++ L I + D G Y+C+
Sbjct: 3058 ALPEPTVTW------------YKDGQPLVLAQRTQALRGGQRLEIQEAQVSDKGLYSCKV 3105
Query: 639 RNVYTGEEI 647
NV GE +
Sbjct: 3106 SNV-AGEAV 3113
Score = 42.4 bits (98), Expect = 0.001
Identities = 42/175 (24%), Positives = 69/175 (39%), Gaps = 15/175 (8%)
Query: 295 VLTIDKMQNKDKGLYTCRVRS--GPSFKSVNTSVHIYDKAFITVKHRKQQVLETVAGKRS 352
VLT+ + D G Y+C S G + V VH+ +++ +V S
Sbjct: 2034 VLTLASARASDSGRYSCVAVSAVGEDRQDVVLQVHMPPSIL------GEELNVSVVANES 2087
Query: 353 YRLSMKVKAFPSPEVVWLKDGLPATEKSARYLTRGYSLIIKDVTEE-DAGNYTILLSIKQ 411
L + A P P + W KDG P + +L+ +L+ D + DAG+YT +
Sbjct: 2088 VALECQSHAMPPPVLSWWKDGRPLEPRPGVHLSADKALLQVDRADVWDAGHYTCEALNQA 2147
Query: 412 SNVFKNLTATLIVNVKPQIYEKAVSSFPDPALYPLGSRQILTCTAYGIPQPTIKW 466
+ K+ + V + E + + G L+C G+P P I W
Sbjct: 2148 GHSEKHYNLNVWVAPVFPLRESHTLTVRE------GHPTSLSCECRGVPFPKISW 2196
Score = 38.5 bits (88), Expect = 0.021
Identities = 30/115 (26%), Positives = 51/115 (44%), Gaps = 10/115 (8%)
Query: 355 LSMKVKAFPSPEVVWLKDGLPAT---EKSARYLTRGYSLIIKDVTEEDAGNYTILLSIKQ 411
L + P P VVW KDG ++ A L +L++ +D+ + ++S +
Sbjct: 3783 LPCEASGSPKPLVVWWKDGQKLDFRLQQGAYRLLPSNALLLTAPGPQDSAQFECVVSNEV 3842
Query: 412 SNVFKNLTATLIVNVKPQIYEKAVSSFPDPALYPLGSRQILTCTAYGIPQPTIKW 466
+ T V+V P I + + F + P+ +LTC + GIP PT+ W
Sbjct: 3843 GEAHRLYQVT--VHVPPTIADDQ-TDFTVTMMAPV----VLTCHSTGIPAPTVSW 3890
Score = 38.1 bits (87), Expect = 0.027
Identities = 77/358 (21%), Positives = 130/358 (36%), Gaps = 64/358 (17%)
Query: 296 LTIDKMQNKDKGLYTCRVRSGPSFKSVNTSVHIYDKAFITVKHRKQ---QVLETVAGKRS 352
L + ++Q D G Y C S P+ ++ H Y + V + Q +VL+ + G+ +
Sbjct: 1084 LRLAQVQVGDSGHYECTA-SNPA----GSASHRYVLG-VQVPPQVQPGPRVLKVLVGE-A 1136
Query: 353 YRLSMKVKAFPSPEVVWLKDGLPATEKSARYLTRGYSLIIKDVTEEDAGNYTILLSIKQS 412
L+ + P P++ W KDG+ + + S+ + DAG Y S S
Sbjct: 1137 LDLNCVAEGNPEPQLSWSKDGVVLQGRGPQG-----SVHFAAIRTSDAGRYRCEAS--NS 1189
Query: 413 NVFKNLTATLIVNVKPQIYEKAVSSFPDPALYPLGSRQILTCTAYGIPQPTIKWFWHPCN 472
L V P S + G L C A G P+P + W P +
Sbjct: 1190 AGVDAWEVELRVLEPPHWGADETSGLLERVA---GENASLPCPARGTPKPQVTWRKGPSS 1246
Query: 473 HN-HSEARCDFCSNNEESFILDADSNMGNRIESITQRMAIIEGKNKMASTLVVADSRISG 531
H + +A++E + +++ ADS G
Sbjct: 1247 EPLHGQPG-----------------------------VAVLEEGSLFLASVSPADS---G 1274
Query: 532 IYICIASNKVGTVGRNISFYITDVP----NGFHVNLEKMPTEGEDLKLSCTVNKFLYRDV 587
Y C A+N+VG+ R + P +G N+ M G+ L L C N F ++
Sbjct: 1275 DYECQATNEVGSTSRRAKLVVYVPPSIREDGRKANVSGM--AGQSLTLECDANGFPVPEI 1332
Query: 588 TWILLRTVNNRTMHYSISKQKMAITKEHSITL-----NLTIMNVSLQDSGTYACRARN 640
W+ + + ++ + + L +L + DSG Y+CRA N
Sbjct: 1333 VWLKDAQLVGVPLGWAGYGWDLGWGQVGGHRLLDEGQSLHFPRIQEGDSGLYSCRAEN 1390
Score = 37.7 bits (86), Expect = 0.036
Identities = 40/178 (22%), Positives = 69/178 (38%), Gaps = 17/178 (9%)
Query: 295 VLTIDKMQNKDKGLYTCRVRSGPSFKSVNTSVHIYDKAFITVKHRKQQVLETVAGKRSYR 354
VL I++ Q D G Y C + + + + IT+ + V R
Sbjct: 1940 VLRIEQAQLSDAGSYRCVASNVAGSTELRYGLRVNVPPRITLP---PSLPGPVLVNTPVR 1996
Query: 355 LSMKVKAFPSPEVVWLKDG---LPATEKSARYLTRGYSLIIKDVTEEDAGNYTILLSIKQ 411
L+ PSP ++WLKDG PA + G L + D+G Y+ +
Sbjct: 1997 LTCNATGAPSPTLMWLKDGNPVSPAGTPGLQVFPGGRVLTLASARASDSGRYSCVAVSAV 2056
Query: 412 SNVFKNLTATLIVNVKPQIY--EKAVSSFPDPALYPLGSRQILTCTAYGIPQPTIKWF 467
+++ L V++ P I E VS + ++ L C ++ +P P + W+
Sbjct: 2057 GEDRQDV--VLQVHMPPSILGEELNVSVVANESV-------ALECQSHAMPPPVLSWW 2105
Score = 37.0 bits (84), Expect = 0.061
Identities = 90/417 (21%), Positives = 144/417 (34%), Gaps = 69/417 (16%)
Query: 77 TKSACGRNGKQFCSTLTLNTAQANHTGFYSCKYLAVPTSKKKETESAIYIFISDTGRPFV 136
TK R G+Q L L AQ++ G Y+CK + +K T +Y+ P +
Sbjct: 1547 TKVVYTRGGRQ----LQLGRAQSSDAGVYTCKASNAVGAAEKATRLDVYV------PPTI 1596
Query: 137 EMYSEIPEIIHMTEGRELVIPCRVTS-PNITVTLKKFPLDTLIPDGKRIIWDSRKGFIIS 195
E P ++ GR + + C P+ T++ L + R+ D +
Sbjct: 1597 EGAGGRPYVVKAVAGRPVALECVARGHPSPTLSWHHEGLPVAESNESRLETDG-SVLRLE 1655
Query: 196 NATYKEIGLLTCEATVNGHLYKTNYLTHRQTNTIIDVQISTPRPVKLLRGHTLVLNCTAT 255
+ GL +C A+ Y Q + V + V + G L L C A+
Sbjct: 1656 SPGEASSGLYSCVASSPAGEAVLQYSVEVQVPPQLLVAEGLGQ-VTTIVGQPLELPCQAS 1714
Query: 256 -TPLNTRVQMTWSYPDEKNKRASVRRRIDQSNSHANIFYSVLTIDKMQNKDKGLYTCRV- 313
+P+ T + P E+ V + + L ID ++ GL+ C+
Sbjct: 1715 GSPVPTIQWLQNGRPAEELAGVQVASQ-----------GTTLHIDHVELDHSGLFACQAT 1763
Query: 314 -RSGPSFKSVNTSVHIYDKAFITVKHRKQQVLETVAGKRSYRLSMKVK------------ 360
+G + V SVH VLE G+ +
Sbjct: 1764 NEAGTAGAEVEVSVH---------GEWAPGVLEVPIGQYHWGXEHHSSFPAACDPPVHRG 1814
Query: 361 --AFPSPEVV--WLKDGLPATEKSARYLTRGYS----LIIKDVTEEDAGNYTILLSIKQS 412
A P P +V W G E + + YS L I+ V D G YT +
Sbjct: 1815 WGAHPKPPLVEGWCSPGSLWGEPTG--IPVAYSLPPPLQIEKVDLRDEGIYTCAATNLAG 1872
Query: 413 NVFKNLTATLIV--NVKPQIYEKAVSSFPDPALYPLGSRQILTCTAYGIPQPTIKWF 467
+ + ++V N++P KAV + L C A G+P P + WF
Sbjct: 1873 ESKREVALKVLVPPNIEPGPVNKAVLE---------NASVTLECLASGVPPPDVSWF 1920
Score = 35.0 bits (79), Expect = 0.23
Identities = 42/174 (24%), Positives = 65/174 (37%), Gaps = 9/174 (5%)
Query: 296 LTIDKMQNKDKGLYTCRVRSGPSFKSVNTSVHIYDKAFITVKHRKQQVLETVAGKRSYRL 355
L ++Q D GLY+CR + + + + + Q+VL +AG L
Sbjct: 1371 LHFPRIQEGDSGLYSCRAENQAGTAQRDFHLLVLTPPSVLGAGAAQEVL-GLAG-ADVEL 1428
Query: 356 SMKVKAFPSPEVVWLKDGLPATEKSARYLTR--GYSLIIKDVTEEDAGNYTILLSIKQSN 413
P+P+V W KD P + G L I D G Y +
Sbjct: 1429 QCWTSGVPTPQVEWTKDRQPVLPGGPHLQVQEDGQVLRITGSHVGDEGRYQCVAFSPAGQ 1488
Query: 414 VFKNLTATLIVNVKPQIYEKAVSSFPDPALYPLGSRQILTCTAYGIPQPTIKWF 467
++ L V+ P I+ + + A+ Q+L C A G+P P I WF
Sbjct: 1489 QARDF--QLRVHAPPTIW--GSNETGEVAVMEDHLVQLL-CEARGVPTPNITWF 1537
Score = 30.8 bits (68), Expect = 4.4
Identities = 34/137 (24%), Positives = 54/137 (39%), Gaps = 12/137 (8%)
Query: 296 LTIDKMQNKDKGLYTCRVRSGPSFKSVNTSVHIYDKAFITVKHRKQQVLETVAGKRSYRL 355
LTI + + D G Y C + + + V+ + TV L
Sbjct: 4273 LTIHRTERDDAGRYQCLAENEMGVAKKVVILVLQSAPVFQVEPQDM----TVRSGDDVAL 4328
Query: 356 SMKVKAFPSPEVVWLKDGLP-ATEKSARYLTRGYSLIIKDVTEEDAGNYTILLSIKQSNV 414
+ P+P + WL+ G P + R L G SL +++V DAG Y + N+
Sbjct: 4329 RCQATGEPTPTIEWLQAGQPLRASRRLRTLPDG-SLWLENVETGDAGTYDCV----AHNL 4383
Query: 415 FKNLTAT--LIVNVKPQ 429
+ TA L+V +PQ
Sbjct: 4384 LGSATARAFLVVRGEPQ 4400
>gi|157311649 neogenin homolog 1 [Homo sapiens]
Length = 1461
Score = 71.6 bits (174), Expect = 2e-12
Identities = 92/400 (23%), Positives = 146/400 (36%), Gaps = 52/400 (13%)
Query: 243 LRGHTLVLNCTATTPLNTRVQMTWSYPDEKNKRASVRRRIDQSNSHANIFYSVLTIDKMQ 302
+RG +++LNC+A + + +++ W S RR Q ++F S + K
Sbjct: 65 VRGSSVILNCSAYSEPSPKIE--WKKDGTFLNLVSDDRR--QLLPDGSLFISNVVHSKHN 120
Query: 303 NKDKGLYTCRVRSGPSFKSVNTSVHIYDKAFITVKHR--KQQVLETVAGKRSYRLSMKVK 360
D+G Y C + +S+ T + K + R Q +V + L+ +V
Sbjct: 121 KPDEGYYQCVA----TVESLGTIISRTAKLIVAGLPRFTSQPEPSSVYAGNNAILNCEVN 176
Query: 361 AFPSPEVVWLKDGLPATEKSARYLTRGYSLIIKDVTEEDAGNYTILLSIKQSNVFKNLTA 420
A P V W ++ P L+I + TE D G Y ++ + +
Sbjct: 177 ADLVPFVRWEQNRQPLLLDDRVIKLPSGMLVISNATEGDGGLYRCVVESGGPPKYSDEVE 236
Query: 421 TLIVNVKPQIYEKAVSSFPDPALYPLGSRQILTCTAYGIPQPTIKWFWHPCNHNHSEARC 480
++ I + P P + +G +L C A G+P PTIKW
Sbjct: 237 LKVLPDPEVISDLVFLKQPSPLVRVIGQDVVLPCVASGLPTPTIKWM------------- 283
Query: 481 DFCSNNEESFILDADSNMGNRIESITQRMAIIEGKNKMASTLVVADSRISGIYICIASNK 540
NEE+ LD +S ++R+ ++ G + S + D +G Y CIA N
Sbjct: 284 ----KNEEA--LDTES---------SERLVLLAGGSLEISDVTEDD---AGTYFCIADNG 325
Query: 541 VGTVGRNISFYITDVPNGFHVNLEKMPTEGEDLKLSCTVNKFLYRDVTWILLRTVNNRTM 600
T+ + P E D+ C V V W V N M
Sbjct: 326 NETIEAQAELTVQAQPEFLKQPTNIYAHESMDIVFECEVTGKPTPTVKW-----VKNGDM 380
Query: 601 HYSISKQKMAITKEHSITLNLTIMNVSLQDSGTYACRARN 640
I I KEH NL ++ + D G Y C A N
Sbjct: 381 --VIPSDYFKIVKEH----NLQVLGLVKSDEGFYQCIAEN 414
Score = 60.8 bits (146), Expect = 4e-09
Identities = 104/466 (22%), Positives = 161/466 (34%), Gaps = 81/466 (17%)
Query: 177 LIPDGKRIIWDSRKGFIISNATYKEIGLLTCEATVNGHLYKTNYLTHRQTNTIIDVQ--- 233
L+PDG I + S + G C ATV + R I+
Sbjct: 103 LLPDGSLFI----SNVVHSKHNKPDEGYYQCVATVES----LGTIISRTAKLIVAGLPRF 154
Query: 234 ISTPRPVKLLRGHTLVLNCTATTPLNTRVQMTWSYPDEKNKRASVRRRIDQSNSHANIFY 293
S P P + G+ +LNC L V+ W E+N R+ + + +
Sbjct: 155 TSQPEPSSVYAGNNAILNCEVNADLVPFVR--W----EQN-----RQPLLLDDRVIKLPS 203
Query: 294 SVLTIDKMQNKDKGLYTCRVRSG--PSFKSVNTSVHIYDKAFIT--VKHRKQQVLETVAG 349
+L I D GLY C V SG P + + D I+ V ++ L V G
Sbjct: 204 GMLVISNATEGDGGLYRCVVESGGPPKYSDEVELKVLPDPEVISDLVFLKQPSPLVRVIG 263
Query: 350 KRSYRLSMKVKAFPSPEVVWLK--DGLPATEKSARYLTRGYSLIIKDVTEEDAGNYTILL 407
+ L P+P + W+K + L L G SL I DVTE+DAG Y +
Sbjct: 264 -QDVVLPCVASGLPTPTIKWMKNEEALDTESSERLVLLAGGSLEISDVTEDDAGTYFCIA 322
Query: 408 SIKQSNVFKNLTATLIVNVKPQIYEKAVSSFPDPALYPLGSRQILTCTAYGIPQPTIKWF 467
N A L V +P+ ++ + + ++ + C G P PT+KW
Sbjct: 323 D--NGNETIEAQAELTVQAQPEFLKQPTNIYAHESM-----DIVFECEVTGKPTPTVKWV 375
Query: 468 WHPCNHNHSEARCDFCSNNEESFILDADSNMGNRIESITQRMAIIEGKNKMASTLVVADS 527
++ +D I++ N LV +D
Sbjct: 376 ------------------KNGDMVIPSD------------YFKIVKEHNLQVLGLVKSD- 404
Query: 528 RISGIYICIASNKVGTVGRNISFYITDVPNGFHVNLEKMPTEGEDLKLSCTVNKFLYRDV 587
G Y CIA N VG I + +P+ D+ S +F+ +
Sbjct: 405 --EGFYQCIAENDVGNAQAGAQLIILE---HAPATTGPLPSAPRDVVASLVSTRFI--KL 457
Query: 588 TW-ILLRTVNNRTMHYSISKQKMAITKE------HSITLNLTIMNV 626
TW + + YS+ K I +E H + +TI N+
Sbjct: 458 TWRTPASDPHGDNLTYSVFYTKEGIARERVENTSHPGEMQVTIQNL 503
>gi|115529482 neural cell adhesion molecule 1 isoform 2 [Homo
sapiens]
Length = 858
Score = 71.2 bits (173), Expect = 3e-12
Identities = 114/503 (22%), Positives = 184/503 (36%), Gaps = 89/503 (17%)
Query: 175 DTLIPDGKRI--IW--DSRKGFIISNATYKEIGLLTC----------EATVNGHLYKTNY 220
+ L P+ +RI +W DS I NA + G+ C EATVN +++
Sbjct: 60 EKLTPNQQRISVVWNDDSSSTLTIYNANIDDAGIYKCVVTGEDGSESEATVNVKIFQKLM 119
Query: 221 LTHRQTNTIIDVQISTPRPVKLLRGHTLVLNCTATTPLNTRVQMTWSYPDEKNKRASVRR 280
+ P P + G V+ C + L + W + R
Sbjct: 120 FKN------------APTPQEFREGEDAVIVCDVVSSLPPTI--IWKHKGRDVILKKDVR 165
Query: 281 RIDQSNSHANIFYSVLTIDKMQNKDKGLYTCR----VRSGPSFKSVNTSVHIYDKAFITV 336
I SN++ L I ++ D+G Y C R +FK + V++ T+
Sbjct: 166 FIVLSNNY-------LQIRGIKKTDEGTYRCEGRILARGEINFKDIQVIVNVPP----TI 214
Query: 337 KHRKQQVLETVAGKRSYRLSMKVKAFPSPEVVWLKDG--LPATEKSARYLTRGYS--LII 392
+ R+ V T +S L + FP P + W KDG + E +Y+ S L I
Sbjct: 215 QARQNIVNATANLGQSVTLVCDAEGFPEPTMSWTKDGEQIEQEEDDEKYIFSDDSSQLTI 274
Query: 393 KDVTEEDAGNYTILLSIKQSNVFKNLTATLIVNVKPQIYEKAVSSFPDPALYPLGSRQIL 452
K V + D Y + K ++ T L V KP+I + + L + L
Sbjct: 275 KKVDKNDEAEYICIAENKAGE--QDATIHLKVFAKPKI-----TYVENQTAMELEEQVTL 327
Query: 453 TCTAYGIPQPTIKWFWHPCNHNHSEARCDFCSNNEESFILDADSNMGNRIESITQRMAII 512
TC A G P P+I W N + E A + E++ M +
Sbjct: 328 TCEASGDPIPSITWRTSTRNISSEEK---------------ASWTRPEKQETLDGHMVVR 372
Query: 513 EGKNKMASTLVVADSRISGIYICIASNKVGTVGRNISFYITDVPNGFHVNLEKMPTEGED 572
+ TL +G YIC ASN +G +++ + P + EG
Sbjct: 373 SHARVSSLTLKSIQYTDAGEYICTASNTIGQDSQSMYLEVQYAPK-LQGPVAVYTWEGNQ 431
Query: 573 LKLSCTVNKFLYRDVTWI----LLRTVN--NRTMHYSISKQKMAITKEHSITLNLTIMNV 626
+ ++C V + ++W LL + N N ++ + S + +T +
Sbjct: 432 VNITCEVFAYPSATISWFRDGQLLPSSNYSNIKIYNTPSASYLEVTPD------------ 479
Query: 627 SLQDSGTYACRARNVYTGEEILQ 649
S D G Y C A N G+E L+
Sbjct: 480 SENDFGNYNCTAVN-RIGQESLE 501
Score = 53.1 bits (126), Expect = 8e-07
Identities = 96/468 (20%), Positives = 167/468 (35%), Gaps = 72/468 (15%)
Query: 33 ELSLKGTQHIMQAGQTLHLQCR--GEAAHK---WSLP--EMVSKESERLSITKSACGRNG 85
++ + +Q + G++ C+ G+A K W P E ++ +R+S+ +
Sbjct: 21 QVDIVPSQGEISVGESKFFLCQVAGDAKDKDISWFSPNGEKLTPNQQRISVVWN------ 74
Query: 86 KQFCSTLTLNTAQANHTGFYSCKYLAVPTSKKKETESAIYIFISDTGRPFVEMYSEIPEI 145
STLT+ A + G Y C V E+E+ + + I M+ P
Sbjct: 75 DDSSSTLTIYNANIDDAGIYKC---VVTGEDGSESEATVNVKIFQK-----LMFKNAPTP 126
Query: 146 IHMTEGRELVIPCRVTSP-NITVTLKKFPLDTLIPDGKRIIWDSRKGFIISNATYKEIGL 204
EG + VI C V S T+ K D ++ R I S I + G
Sbjct: 127 QEFREGEDAVIVCDVVSSLPPTIIWKHKGRDVILKKDVRFIVLSNNYLQIRGIKKTDEGT 186
Query: 205 LTCEATVNGHLYKTNYLTHRQTNTIIDVQISTPRPVKLLRGHTLVLNCTATTPLN-TRVQ 263
CE G + + + I++V + ++ ++N TA + T V
Sbjct: 187 YRCE----GRILARGEINFKDIQVIVNVPPT-------IQARQNIVNATANLGQSVTLVC 235
Query: 264 MTWSYPDEKNKRASVRRRIDQSNSHANIFYS----VLTIDKMQNKDKGLYTCRVRSGPSF 319
+P+ +I+Q +S LTI K+ D+ Y C +
Sbjct: 236 DAEGFPEPTMSWTKDGEQIEQEEDDEKYIFSDDSSQLTIKKVDKNDEAEYICIAENKAGE 295
Query: 320 KSVNTSVHIYDKAFIT-VKHRKQQVLETVAGKRSYRLSMKVKAFPSPEVVWLKD--GLPA 376
+ + ++ K IT V+++ LE L+ + P P + W + +
Sbjct: 296 QDATIHLKVFAKPKITYVENQTAMELE-----EQVTLTCEASGDPIPSITWRTSTRNISS 350
Query: 377 TEKSA----------------RYLTRGYSLIIKDVTEEDAGNYTILLSIKQSNVFKNLTA 420
EK++ R R SL +K + DAG Y S +++
Sbjct: 351 EEKASWTRPEKQETLDGHMVVRSHARVSSLTLKSIQYTDAGEYICTASNTIGQDSQSMY- 409
Query: 421 TLIVNVKPQIYEKAVSSFPDPALYPLGSRQI-LTCTAYGIPQPTIKWF 467
L V P++ A+Y Q+ +TC + P TI WF
Sbjct: 410 -LEVQYAPKLQGPV-------AVYTWEGNQVNITCEVFAYPSATISWF 449
Score = 34.7 bits (78), Expect = 0.30
Identities = 35/158 (22%), Positives = 63/158 (39%), Gaps = 29/158 (18%)
Query: 499 GNRIESITQRMAIIEGKNKMASTLVVADSRI--SGIYICIASNKVGT---------VGRN 547
G ++ QR++++ + +STL + ++ I +GIY C+ + + G+ + +
Sbjct: 59 GEKLTPNQQRISVVWNDDS-SSTLTIYNANIDDAGIYKCVVTGEDGSESEATVNVKIFQK 117
Query: 548 ISFYITDVPNGFHVNLEKMPTEGEDLKLSCTVNKFLYRDVTWILLRTVNNRTMHYSISKQ 607
+ F P F EGED + C V L + W ++ + K
Sbjct: 118 LMFKNAPTPQEFR--------EGEDAVIVCDVVSSLPPTIIW------KHKGRDVILKKD 163
Query: 608 KMAITKEHSITLNLTIMNVSLQDSGTYACRARNVYTGE 645
I ++ L I + D GTY C R + GE
Sbjct: 164 VRFIVLSNNY---LQIRGIKKTDEGTYRCEGRILARGE 198
>gi|28373122 contactin 4 isoform a precursor [Homo sapiens]
Length = 1026
Score = 69.7 bits (169), Expect = 8e-12
Identities = 109/491 (22%), Positives = 171/491 (34%), Gaps = 75/491 (15%)
Query: 180 DGKRIIWDSRKGFIISNATYKEIGLLTCEAT--VNGH--LYKTNYLTHRQTNTIID---- 231
D +R + I+ ++G TC T V H L L R + +
Sbjct: 167 DNRRFVSQETGNLYIAKVEKSDVGNYTCVVTNTVTNHKVLGPPTPLILRNDGVMGEYEPK 226
Query: 232 VQISTPRPVKLLRGHTLVLNCTAT-TPLNTRVQMTWSYPDEKNKRASVRRRIDQSNSHAN 290
+++ P V +G T+ L C A P+ T + W D K RR +SN
Sbjct: 227 IEVQFPETVPTAKGATVKLECFALGNPVPTII---WRRADGKPIARKARRH--KSNG--- 278
Query: 291 IFYSVLTIDKMQNKDKGLYTCRVRSGPSFKSVNTSVHIYDKAFITVKHRKQQVLET-VAG 349
+L I Q +D GLY C + S +V F + Q++ + VA
Sbjct: 279 ----ILEIPNFQQEDAGLYECVAEN-----SRGKNVARGQLTFYAQPNWIQKINDIHVAM 329
Query: 350 KRSYRLSMKVKAFPSPEVVWLKDGLPATEKSARYLTRGYSLIIKDVTEEDAGNYTILLSI 409
+ + K P P WLK+G P + + +G +L I V DAG Y L
Sbjct: 330 EENVFWECKANGRPKPTYKWLKNGEPLLTRDRIQIEQG-TLNITIVNLSDAGMYQCLAEN 388
Query: 410 KQSNVFKNLTATLIVNVKPQIYEKAVSSFPDPALYPLGSRQILTCTAYGIPQPTIKWFWH 469
K +F N ++I V P + L +G ++ C P+P W
Sbjct: 389 KHGVIFSNAELSVIA-VGPDFSRTLLKRV---TLVKVGGEVVIECKPKASPKPVYTW--- 441
Query: 470 PCNHNHSEARCDFCSNNEESFILDADSNMGNRIESITQRMAIIEGKNKMASTLVVADSRI 529
G I +R+ I E N + +D
Sbjct: 442 ---------------------------KKGRDILKENERITISEDGNLRIINVTKSD--- 471
Query: 530 SGIYICIASNKVGTVGRNISFYITDVPNGFHVNLEKMP-TEGEDLKLSCTVNKFLYRDV- 587
+G Y CIA+N GT + + D P V M T GE + L C V D+
Sbjct: 472 AGSYTCIATNHFGTASSTGNLVVKD-PTRVMVPPSSMDVTVGESIVLPCQVTHDHSLDIV 530
Query: 588 -TWILLRTVNNRTMHYSISKQKMAITKEHSITLNLTIMNVSLQDSGTYACRARNVYTGEE 646
TW + N + + +L I N+ L+ +G Y C + + +
Sbjct: 531 FTW----SFNGHLIDFDRDGDHFERVGGQDSAGDLMIRNIQLKHAGKYVCMVQT--SVDR 584
Query: 647 ILQKKEITIRG 657
+ ++ +RG
Sbjct: 585 LSAAADLIVRG 595
Score = 61.6 bits (148), Expect = 2e-09
Identities = 94/421 (22%), Positives = 154/421 (36%), Gaps = 83/421 (19%)
Query: 236 TPRPVKLLRGHTLVLNCTATTPLNTRVQMTW---SYPDEKNKRASVRRRIDQSNSHANIF 292
T V + RG +VL C P + + W YP ++ R V S N++
Sbjct: 128 TRSTVSVRRGQGMVLLC-GPPPHSGELSYAWIFNEYPSYQDNRRFV------SQETGNLY 180
Query: 293 YSVLTIDKMQNKDKGLYTCRVRS--------GPSFKSVNTSVHIYDKAFITVKHRKQQVL 344
I K++ D G YTC V + GP + + + + ++ + + +
Sbjct: 181 -----IAKVEKSDVGNYTCVVTNTVTNHKVLGPPTPLILRNDGVMGEYEPKIEVQFPETV 235
Query: 345 ETVAGKRSYRLSMKVKAFPSPEVVWLK-DGLPATEKSARYLTRGYSLIIKDVTEEDAGNY 403
T G + +L P P ++W + DG P K+ R+ + G L I + +EDAG Y
Sbjct: 236 PTAKGA-TVKLECFALGNPVPTIIWRRADGKPIARKARRHKSNGI-LEIPNFQQEDAGLY 293
Query: 404 TILLSIKQSNVFKNLT-ATLIVNVKPQIYEKAVSSFPDPALYPLGSRQILTCTAYGIPQP 462
+ +++ KN+ L +P +K + + C A G P+P
Sbjct: 294 EC---VAENSRGKNVARGQLTFYAQPNWIQKI-----NDIHVAMEENVFWECKANGRPKP 345
Query: 463 TIKWFWHPCNHNHSEARCDFCSNNEESFILDADSNMGNRIESITQRMAIIEGKNKMASTL 522
T KW N E D R+ I +G +
Sbjct: 346 TYKWL----------------KNGEPLLTRD--------------RIQIEQG----TLNI 371
Query: 523 VVADSRISGIYICIASNKVGTVGRNISFYITDVPNGFHVNLEKMPT---EGEDLKLSCTV 579
+ + +G+Y C+A NK G + N + V F L K T G ++ + C
Sbjct: 372 TIVNLSDAGMYQCLAENKHGVIFSNAELSVIAVGPDFSRTLLKRVTLVKVGGEVVIECKP 431
Query: 580 NKFLYRDVTWILLRTVNNRTMHYSISKQKMAITKEHSITLNLTIMNVSLQDSGTYACRAR 639
TW R + +IS+ NL I+NV+ D+G+Y C A
Sbjct: 432 KASPKPVYTWKKGRDILKENERITISEDG-----------NLRIINVTKSDAGSYTCIAT 480
Query: 640 N 640
N
Sbjct: 481 N 481
Score = 43.5 bits (101), Expect = 7e-04
Identities = 85/364 (23%), Positives = 138/364 (37%), Gaps = 75/364 (20%)
Query: 294 SVLTIDKMQNKDKGLYTCRVRSGPSFKSVNTSVHIYDKA-FITVKHRKQQVLETVAGKRS 352
S+L + + +D G Y C + S T V K F + + K + TV+ +R
Sbjct: 83 SLLINNPNKTQDAGTYQCTATN-----SFGTIVSREAKLQFAYLDNFKTRTRSTVSVRRG 137
Query: 353 YRLSMKVKAFPSPE-----VVWLKDGLPATEKSARYLTRGY-SLIIKDVTEEDAGNYTIL 406
M + P P W+ + P+ + + R++++ +L I V + D GNYT +
Sbjct: 138 Q--GMVLLCGPPPHSGELSYAWIFNEYPSYQDNRRFVSQETGNLYIAKVEKSDVGNYTCV 195
Query: 407 LSIKQSN--VFKNLTATLIVN--VKPQIYEKAVSSFPDPALYPLGSRQILTCTAYGIPQP 462
++ +N V T ++ N V + K FP+ G+ L C A G P P
Sbjct: 196 VTNTVTNHKVLGPPTPLILRNDGVMGEYEPKIEVQFPETVPTAKGATVKLECFALGNPVP 255
Query: 463 TIKWFWHPCNHNHSEARCDFCSNNEESFILDADSNMGNRIESITQRMAIIEGKNKMASTL 522
TI W AD R + I+E N
Sbjct: 256 TIIW-------------------------RRADGKPIARKARRHKSNGILEIPN------ 284
Query: 523 VVADSRISGIYICIASNKVG-TVGR-NISFYI----TDVPNGFHVNLEKMPTEGEDLKLS 576
+G+Y C+A N G V R ++FY N HV +E E++
Sbjct: 285 --FQQEDAGLYECVAENSRGKNVARGQLTFYAQPNWIQKINDIHVAME------ENVFWE 336
Query: 577 CTVNKFLYRDVTWILLRTVNNRTMHYSISKQKMAITKEHSITLNLTIMNVSLQDSGTYAC 636
C N W+ + +++ ++ I + TLN+TI+N+S D+G Y C
Sbjct: 337 CKANGRPKPTYKWL-------KNGEPLLTRDRIQIEQG---TLNITIVNLS--DAGMYQC 384
Query: 637 RARN 640
A N
Sbjct: 385 LAEN 388
Score = 37.7 bits (86), Expect = 0.036
Identities = 84/381 (22%), Positives = 139/381 (36%), Gaps = 53/381 (13%)
Query: 43 MQAGQTLHLQC-----RGEAAHKWSLPEMVSKESERLSITKSACGRNGKQFCSTLTLNTA 97
++ GQ + L C GE ++ W E S + R +++ L +
Sbjct: 134 VRRGQGMVLLCGPPPHSGELSYAWIFNEYPSYQDNRRFVSQET---------GNLYIAKV 184
Query: 98 QANHTGFYSCKYLAVPTSKKKETESAIYIFISD--TGRPFVEMYSEIPEIIHMTEGRELV 155
+ + G Y+C T+ K I +D G ++ + PE + +G +
Sbjct: 185 EKSDVGNYTCVVTNTVTNHKVLGPPTPLILRNDGVMGEYEPKIEVQFPETVPTAKGATVK 244
Query: 156 IPC-RVTSPNITVTLKKFPLDTLIPDGKRIIWDSRK----GFI-ISNATYKEIGLLTCEA 209
+ C + +P T+ ++ DGK I +R+ G + I N ++ GL C A
Sbjct: 245 LECFALGNPVPTIIWRR-------ADGKPIARKARRHKSNGILEIPNFQQEDAGLYECVA 297
Query: 210 -TVNGHLYKTNYLT-HRQTNTIIDVQISTPRPVKLLRGHTLVLNCTATTPLNTRVQMTWS 267
G LT + Q N I + + + + C A N R + T+
Sbjct: 298 ENSRGKNVARGQLTFYAQPNWIQKIN-----DIHVAMEENVFWECKA----NGRPKPTYK 348
Query: 268 YPDEKNKRASVRRRIDQSNSHANIFYSVLTIDKMQNKDKGLYTCRVRS--GPSFKSVNTS 325
+ KN + R I L I + D G+Y C + G F + S
Sbjct: 349 WL--KNGEPLLTR------DRIQIEQGTLNITIVNLSDAGMYQCLAENKHGVIFSNAELS 400
Query: 326 VHIYDKAFITVKHRKQQVLETVAGKRSYRLSMKVKAFPSPEVVWLKDGLPATEKSARYLT 385
V F K+ L V G+ + K KA P P W K E ++
Sbjct: 401 VIAVGPDFSRTL-LKRVTLVKVGGE--VVIECKPKASPKPVYTWKKGRDILKENERITIS 457
Query: 386 RGYSLIIKDVTEEDAGNYTIL 406
+L I +VT+ DAG+YT +
Sbjct: 458 EDGNLRIINVTKSDAGSYTCI 478
Score = 36.6 bits (83), Expect = 0.079
Identities = 42/170 (24%), Positives = 69/170 (40%), Gaps = 16/170 (9%)
Query: 151 GRELVIPCRV-TSPNITVTLKKFPLDTLIPDGKRIIWDSRKGFIISNATYKEIGLLTCEA 209
G E+VI C+ SP T KK ++ + +RI I N T + G TC A
Sbjct: 422 GGEVVIECKPKASPKPVYTWKKGR--DILKENERITISEDGNLRIINVTKSDAGSYTCIA 479
Query: 210 TVN-GHLYKTNYLTHRQTNTIIDVQISTPRPVKLLRGHTLVLNCTATTPLNTRVQMTWSY 268
T + G T L + ++ P + + G ++VL C T + + TWS+
Sbjct: 480 TNHFGTASSTGNLVVKDPTRVM----VPPSSMDVTVGESIVLPCQVTHDHSLDIVFTWSF 535
Query: 269 PD---EKNKRASVRRRIDQSNSHANIFYSVLTIDKMQNKDKGLYTCRVRS 315
+ ++ R+ +S + L I +Q K G Y C V++
Sbjct: 536 NGHLIDFDRDGDHFERVGGQDSAGD-----LMIRNIQLKHAGKYVCMVQT 580
Score = 35.0 bits (79), Expect = 0.23
Identities = 50/217 (23%), Positives = 75/217 (34%), Gaps = 49/217 (22%)
Query: 439 PDPALYPLGSRQI---LTCTAYGIPQPTIKWFWHPCNHNHSEARCDFCSNNEESFILDAD 495
P P ++PL S + L C G P+P I+W + D D
Sbjct: 32 PSPVMFPLDSEEKKVKLNCEVKGNPKPHIRWKLNG---------------------TDVD 70
Query: 496 SNMGNRIESITQRMAIIEGKNKMASTLVVADSRISGIYICIASNKVGT-VGRNISFYITD 554
+ M R S+ + +I NK ++ +G Y C A+N GT V R
Sbjct: 71 TGMDFRY-SVVEGSLLINNPNK---------TQDAGTYQCTATNSFGTIVSREAKLQFAY 120
Query: 555 VPNGFHVNLEKMPT--EGEDLKLSCTVNKFLYR-DVTWILLRTVNNRTMHYSISKQKMAI 611
+ N F + G+ + L C WI + S + +
Sbjct: 121 LDN-FKTRTRSTVSVRRGQGMVLLCGPPPHSGELSYAWIF-------NEYPSYQDNRRFV 172
Query: 612 TKEHSITLNLTIMNVSLQDSGTYACRARNVYTGEEIL 648
++E T NL I V D G Y C N T ++L
Sbjct: 173 SQE---TGNLYIAKVEKSDVGNYTCVVTNTVTNHKVL 206
Score = 34.3 bits (77), Expect = 0.39
Identities = 27/124 (21%), Positives = 54/124 (43%), Gaps = 23/124 (18%)
Query: 42 IMQAGQTLHLQCRGEAAHK----WSLPEMVSKESERLSITKSACGRNGKQFCSTLTLNTA 97
+++ G + ++C+ +A+ K W + KE+ER++I++ L +
Sbjct: 418 LVKVGGEVVIECKPKASPKPVYTWKKGRDILKENERITISEDG----------NLRIINV 467
Query: 98 QANHTGFYSCKYLAVPTSKKKETESAIYIFISDTGRPFVEMYSEIPEIIHMTEGRELVIP 157
+ G Y+C + T+ S + + D R V P + +T G +V+P
Sbjct: 468 TKSDAGSYTC----IATNHFGTASSTGNLVVKDPTRVMVP-----PSSMDVTVGESIVLP 518
Query: 158 CRVT 161
C+VT
Sbjct: 519 CQVT 522
>gi|94420689 neural cell adhesion molecule 1 isoform 1 [Homo
sapiens]
Length = 848
Score = 68.6 bits (166), Expect = 2e-11
Identities = 82/355 (23%), Positives = 129/355 (36%), Gaps = 52/355 (14%)
Query: 294 SVLTIDKMQNKDKGLYTCRVRSGPSFKSVNT-SVHIYDKAFITVKHRKQQVLETVAGKRS 352
S LTI D G+Y C V +S T +V I+ K Q+ E G+ +
Sbjct: 79 STLTIYNANIDDAGIYKCVVTGEDGSESEATVNVKIFQKLMFKNAPTPQEFRE---GEDA 135
Query: 353 YRLSMKVKAFPSPEVVWLKDGLPAT-EKSARYLTRGYSLI-IKDVTEEDAGNYTILLSIK 410
+ V + P P ++W G +K R++ + + I+ + + D G Y I
Sbjct: 136 VIVCDVVSSLP-PTIIWKHKGRDVILKKDVRFIVLSNNYLQIRGIKKTDEGTYRCEGRIL 194
Query: 411 QSNVFKNLTATLIVNVKPQIYEKAVSSFPDPALYPLGSRQILTCTAYGIPQPTIKWFWHP 470
+IVNV P I +A + + A LG L C A G P+PT+ W
Sbjct: 195 ARGEINFKDIQVIVNVPPTI--QARQNIVN-ATANLGQSVTLVCDAEGFPEPTMSW---- 247
Query: 471 CNHNHSEARCDFCSNNEESFILDADSNMGNRIESITQRMAIIEGKNKMASTLVVADSRIS 530
+ G +IE I + T+ D
Sbjct: 248 -------------------------TKDGEQIEQEEDDEKYIFSDDSSQLTIKKVDKNDE 282
Query: 531 GIYICIASNKVGTVGRNISFYITDVPNGFHVNLEKMPTEGEDLKLSCTVNKFLYRDVTWI 590
YICIA NK G I + P +V + E + L+C + +TW
Sbjct: 283 AEYICIAENKAGEQDATIHLKVFAKPKITYVENQTAMELEEQVTLTCEASGDPIPSITW- 341
Query: 591 LLRTVNNRTMHYSISKQKMA-----ITKEHSITLNLTIMNVSLQDSGTYACRARN 640
RT +IS ++ + + H+ +LT+ ++ D+G Y C A N
Sbjct: 342 -------RTSTRNISSEEKTLDGHMVVRSHARVSSLTLKSIQYTDAGEYICTASN 389
Score = 56.6 bits (135), Expect = 7e-08
Identities = 96/458 (20%), Positives = 166/458 (36%), Gaps = 62/458 (13%)
Query: 33 ELSLKGTQHIMQAGQTLHLQCR--GEAAHK---WSLP--EMVSKESERLSITKSACGRNG 85
++ + +Q + G++ C+ G+A K W P E ++ +R+S+ +
Sbjct: 21 QVDIVPSQGEISVGESKFFLCQVAGDAKDKDISWFSPNGEKLTPNQQRISVVWN------ 74
Query: 86 KQFCSTLTLNTAQANHTGFYSCKYLAVPTSKKKETESAIYIFISDTGRPFVEMYSEIPEI 145
STLT+ A + G Y C V E+E+ + + I M+ P
Sbjct: 75 DDSSSTLTIYNANIDDAGIYKC---VVTGEDGSESEATVNVKIFQK-----LMFKNAPTP 126
Query: 146 IHMTEGRELVIPCRVTSP-NITVTLKKFPLDTLIPDGKRIIWDSRKGFIISNATYKEIGL 204
EG + VI C V S T+ K D ++ R I S I + G
Sbjct: 127 QEFREGEDAVIVCDVVSSLPPTIIWKHKGRDVILKKDVRFIVLSNNYLQIRGIKKTDEGT 186
Query: 205 LTCEATVNGHLYKTNYLTHRQTNTIIDVQISTPRPVKLLRGHTLVLNCTATTPLN-TRVQ 263
CE G + + + I++V + ++ ++N TA + T V
Sbjct: 187 YRCE----GRILARGEINFKDIQVIVNVPPT-------IQARQNIVNATANLGQSVTLVC 235
Query: 264 MTWSYPDEKNKRASVRRRIDQSNSHANIFYS----VLTIDKMQNKDKGLYTCRVRSGPSF 319
+P+ +I+Q +S LTI K+ D+ Y C +
Sbjct: 236 DAEGFPEPTMSWTKDGEQIEQEEDDEKYIFSDDSSQLTIKKVDKNDEAEYICIAENKAGE 295
Query: 320 KSVNTSVHIYDKAFIT-VKHRKQQVLETVAGKRSYRLSMKVKAFPSPEVVWLKD--GLPA 376
+ + ++ K IT V+++ LE L+ + P P + W + +
Sbjct: 296 QDATIHLKVFAKPKITYVENQTAMELE-----EQVTLTCEASGDPIPSITWRTSTRNISS 350
Query: 377 TEKS------ARYLTRGYSLIIKDVTEEDAGNYTILLSIKQSNVFKNLTATLIVNVKPQI 430
EK+ R R SL +K + DAG Y S +++ L V P++
Sbjct: 351 EEKTLDGHMVVRSHARVSSLTLKSIQYTDAGEYICTASNTIGQDSQSMY--LEVQYAPKL 408
Query: 431 YEKAVSSFPDPALYPLGSRQI-LTCTAYGIPQPTIKWF 467
A+Y Q+ +TC + P TI WF
Sbjct: 409 QGPV-------AVYTWEGNQVNITCEVFAYPSATISWF 439
Score = 34.7 bits (78), Expect = 0.30
Identities = 35/158 (22%), Positives = 63/158 (39%), Gaps = 29/158 (18%)
Query: 499 GNRIESITQRMAIIEGKNKMASTLVVADSRI--SGIYICIASNKVGT---------VGRN 547
G ++ QR++++ + +STL + ++ I +GIY C+ + + G+ + +
Sbjct: 59 GEKLTPNQQRISVVWNDDS-SSTLTIYNANIDDAGIYKCVVTGEDGSESEATVNVKIFQK 117
Query: 548 ISFYITDVPNGFHVNLEKMPTEGEDLKLSCTVNKFLYRDVTWILLRTVNNRTMHYSISKQ 607
+ F P F EGED + C V L + W ++ + K
Sbjct: 118 LMFKNAPTPQEFR--------EGEDAVIVCDVVSSLPPTIIW------KHKGRDVILKKD 163
Query: 608 KMAITKEHSITLNLTIMNVSLQDSGTYACRARNVYTGE 645
I ++ L I + D GTY C R + GE
Sbjct: 164 VRFIVLSNNY---LQIRGIKKTDEGTYRCEGRILARGE 198
Score = 32.7 bits (73), Expect = 1.1
Identities = 34/122 (27%), Positives = 53/122 (43%), Gaps = 12/122 (9%)
Query: 287 SHANIFYSVLTIDKMQNKDKGLYTCRVRSGPSFKSVNTSVHIYDKAFITVKHRKQQVLET 346
SHA + S LT+ +Q D G Y C + S +Y + K + + T
Sbjct: 363 SHARV--SSLTLKSIQYTDAGEYICTASNTIG----QDSQSMYLEVQYAPKLQGPVAVYT 416
Query: 347 VAGKRSYRLSMKVKAFPSPEVVWLKDG--LPATEKSARYLTRGYSLIIKDVT---EEDAG 401
G + ++ +V A+PS + W +DG LP++ S + S +VT E D G
Sbjct: 417 WEGNQ-VNITCEVFAYPSATISWFRDGQLLPSSNYSNIKIYNTPSASYLEVTPDSENDFG 475
Query: 402 NY 403
NY
Sbjct: 476 NY 477
>gi|115529478 neural cell adhesion molecule 1 isoform 3 [Homo
sapiens]
Length = 761
Score = 68.6 bits (166), Expect = 2e-11
Identities = 82/355 (23%), Positives = 129/355 (36%), Gaps = 52/355 (14%)
Query: 294 SVLTIDKMQNKDKGLYTCRVRSGPSFKSVNT-SVHIYDKAFITVKHRKQQVLETVAGKRS 352
S LTI D G+Y C V +S T +V I+ K Q+ E G+ +
Sbjct: 79 STLTIYNANIDDAGIYKCVVTGEDGSESEATVNVKIFQKLMFKNAPTPQEFRE---GEDA 135
Query: 353 YRLSMKVKAFPSPEVVWLKDGLPAT-EKSARYLTRGYSLI-IKDVTEEDAGNYTILLSIK 410
+ V + P P ++W G +K R++ + + I+ + + D G Y I
Sbjct: 136 VIVCDVVSSLP-PTIIWKHKGRDVILKKDVRFIVLSNNYLQIRGIKKTDEGTYRCEGRIL 194
Query: 411 QSNVFKNLTATLIVNVKPQIYEKAVSSFPDPALYPLGSRQILTCTAYGIPQPTIKWFWHP 470
+IVNV P I +A + + A LG L C A G P+PT+ W
Sbjct: 195 ARGEINFKDIQVIVNVPPTI--QARQNIVN-ATANLGQSVTLVCDAEGFPEPTMSW---- 247
Query: 471 CNHNHSEARCDFCSNNEESFILDADSNMGNRIESITQRMAIIEGKNKMASTLVVADSRIS 530
+ G +IE I + T+ D
Sbjct: 248 -------------------------TKDGEQIEQEEDDEKYIFSDDSSQLTIKKVDKNDE 282
Query: 531 GIYICIASNKVGTVGRNISFYITDVPNGFHVNLEKMPTEGEDLKLSCTVNKFLYRDVTWI 590
YICIA NK G I + P +V + E + L+C + +TW
Sbjct: 283 AEYICIAENKAGEQDATIHLKVFAKPKITYVENQTAMELEEQVTLTCEASGDPIPSITW- 341
Query: 591 LLRTVNNRTMHYSISKQKMA-----ITKEHSITLNLTIMNVSLQDSGTYACRARN 640
RT +IS ++ + + H+ +LT+ ++ D+G Y C A N
Sbjct: 342 -------RTSTRNISSEEKTLDGHMVVRSHARVSSLTLKSIQYTDAGEYICTASN 389
Score = 56.6 bits (135), Expect = 7e-08
Identities = 96/458 (20%), Positives = 166/458 (36%), Gaps = 62/458 (13%)
Query: 33 ELSLKGTQHIMQAGQTLHLQCR--GEAAHK---WSLP--EMVSKESERLSITKSACGRNG 85
++ + +Q + G++ C+ G+A K W P E ++ +R+S+ +
Sbjct: 21 QVDIVPSQGEISVGESKFFLCQVAGDAKDKDISWFSPNGEKLTPNQQRISVVWN------ 74
Query: 86 KQFCSTLTLNTAQANHTGFYSCKYLAVPTSKKKETESAIYIFISDTGRPFVEMYSEIPEI 145
STLT+ A + G Y C V E+E+ + + I M+ P
Sbjct: 75 DDSSSTLTIYNANIDDAGIYKC---VVTGEDGSESEATVNVKIFQK-----LMFKNAPTP 126
Query: 146 IHMTEGRELVIPCRVTSP-NITVTLKKFPLDTLIPDGKRIIWDSRKGFIISNATYKEIGL 204
EG + VI C V S T+ K D ++ R I S I + G
Sbjct: 127 QEFREGEDAVIVCDVVSSLPPTIIWKHKGRDVILKKDVRFIVLSNNYLQIRGIKKTDEGT 186
Query: 205 LTCEATVNGHLYKTNYLTHRQTNTIIDVQISTPRPVKLLRGHTLVLNCTATTPLN-TRVQ 263
CE G + + + I++V + ++ ++N TA + T V
Sbjct: 187 YRCE----GRILARGEINFKDIQVIVNVPPT-------IQARQNIVNATANLGQSVTLVC 235
Query: 264 MTWSYPDEKNKRASVRRRIDQSNSHANIFYS----VLTIDKMQNKDKGLYTCRVRSGPSF 319
+P+ +I+Q +S LTI K+ D+ Y C +
Sbjct: 236 DAEGFPEPTMSWTKDGEQIEQEEDDEKYIFSDDSSQLTIKKVDKNDEAEYICIAENKAGE 295
Query: 320 KSVNTSVHIYDKAFIT-VKHRKQQVLETVAGKRSYRLSMKVKAFPSPEVVWLKD--GLPA 376
+ + ++ K IT V+++ LE L+ + P P + W + +
Sbjct: 296 QDATIHLKVFAKPKITYVENQTAMELE-----EQVTLTCEASGDPIPSITWRTSTRNISS 350
Query: 377 TEKS------ARYLTRGYSLIIKDVTEEDAGNYTILLSIKQSNVFKNLTATLIVNVKPQI 430
EK+ R R SL +K + DAG Y S +++ L V P++
Sbjct: 351 EEKTLDGHMVVRSHARVSSLTLKSIQYTDAGEYICTASNTIGQDSQSMY--LEVQYAPKL 408
Query: 431 YEKAVSSFPDPALYPLGSRQI-LTCTAYGIPQPTIKWF 467
A+Y Q+ +TC + P TI WF
Sbjct: 409 QGPV-------AVYTWEGNQVNITCEVFAYPSATISWF 439
Score = 34.7 bits (78), Expect = 0.30
Identities = 35/158 (22%), Positives = 63/158 (39%), Gaps = 29/158 (18%)
Query: 499 GNRIESITQRMAIIEGKNKMASTLVVADSRI--SGIYICIASNKVGT---------VGRN 547
G ++ QR++++ + +STL + ++ I +GIY C+ + + G+ + +
Sbjct: 59 GEKLTPNQQRISVVWNDDS-SSTLTIYNANIDDAGIYKCVVTGEDGSESEATVNVKIFQK 117
Query: 548 ISFYITDVPNGFHVNLEKMPTEGEDLKLSCTVNKFLYRDVTWILLRTVNNRTMHYSISKQ 607
+ F P F EGED + C V L + W ++ + K
Sbjct: 118 LMFKNAPTPQEFR--------EGEDAVIVCDVVSSLPPTIIW------KHKGRDVILKKD 163
Query: 608 KMAITKEHSITLNLTIMNVSLQDSGTYACRARNVYTGE 645
I ++ L I + D GTY C R + GE
Sbjct: 164 VRFIVLSNNY---LQIRGIKKTDEGTYRCEGRILARGE 198
Score = 32.7 bits (73), Expect = 1.1
Identities = 34/122 (27%), Positives = 53/122 (43%), Gaps = 12/122 (9%)
Query: 287 SHANIFYSVLTIDKMQNKDKGLYTCRVRSGPSFKSVNTSVHIYDKAFITVKHRKQQVLET 346
SHA + S LT+ +Q D G Y C + S +Y + K + + T
Sbjct: 363 SHARV--SSLTLKSIQYTDAGEYICTASNTIG----QDSQSMYLEVQYAPKLQGPVAVYT 416
Query: 347 VAGKRSYRLSMKVKAFPSPEVVWLKDG--LPATEKSARYLTRGYSLIIKDVT---EEDAG 401
G + ++ +V A+PS + W +DG LP++ S + S +VT E D G
Sbjct: 417 WEGNQ-VNITCEVFAYPSATISWFRDGQLLPSSNYSNIKIYNTPSASYLEVTPDSENDFG 475
Query: 402 NY 403
NY
Sbjct: 476 NY 477
>gi|239755187 PREDICTED: similar to hemicentin 2 [Homo sapiens]
Length = 1215
Score = 67.4 bits (163), Expect = 4e-11
Identities = 128/632 (20%), Positives = 220/632 (34%), Gaps = 114/632 (18%)
Query: 32 PELSLKGTQHIMQAGQTLHLQCRGEAAH----KWSLPEMVSKESERLSITKSACGRNGKQ 87
P++S+ + G + + C WS +E R+ +
Sbjct: 491 PQVSIHTSSQHFSQGVEVKVSCSASGYPTPHISWSRESQALQEDSRIHVDAQG------- 543
Query: 88 FCSTLTLNTAQANHTGFYSCKYLAVPTSKKKETESAIYIFISDTGRPFVEMYSEIPEIIH 147
TL + G YSC+ T++ + + ++ +D P V S + ++
Sbjct: 544 ---TLIIQGVAPEDAGNYSCQ----ATNEVGTDQETVTLYYTDP--PSV---SAVNAVVL 591
Query: 148 MTEGRELVIPCRVTS-PNITVTLKKFPLDTLI-PDGKRIIWDSRKGFIISNATYKEIGLL 205
+ G E V+ C + P V + L+ ++ P+G S I A ++ G
Sbjct: 592 VAVGEEAVLVCEASGVPPPRVIWYRGGLEMILAPEGS-----SSGKLRIPAAQERDAGTY 646
Query: 206 TCEATVN-GHLYKTNYLTHRQTNTIIDVQISTPRPVKLLRGHTLVLNCTAT-TPLNTRVQ 263
TC A G L + ++ PR V + G + +L C AT P T
Sbjct: 647 TCRAVNELGDASAEIQLAVGHAPQLTEL----PRDVTVELGRSALLACRATGRPPPT--- 699
Query: 264 MTWSYPDEKNKRASVRRRIDQSNSHANIFYSVLTIDKMQNKDKGLYTCRVRSGPSFKSVN 323
+TW D + +R + + VL + + +D+ Y C R+ F V
Sbjct: 700 VTWRRGD--GQPLGLRLGAGRGSRSRQPDSGVLFFESVAPEDQAPYVCEARN--VFGKVQ 755
Query: 324 TSVHIYDKAFITVKHRKQQV------LETVAGKRSYRLSMKVKAFPSPEVVWLKDGLPAT 377
+ I H Q+ + + G+ + + P PE WLKDG P
Sbjct: 756 AEARL-----IVTGHAPPQIASSAPTVRVLEGQPVSLPCIVLAGRPLPERHWLKDGRPLP 810
Query: 378 EKSARYLTRGYSLIIKDVTEEDAGNYTILLSIKQSNVFKNLTATLIVNVKPQIYEKAVSS 437
S + SL + +E AG Y+ + + + +++ L+V V P+I+ A
Sbjct: 811 PGSRHSIRADGSLHLDRALQEHAGRYSCVATNTAGSQHRDV--ELVVQVPPRIHPTATHH 868
Query: 438 FPDPALYPLGSRQILTCTAYGIPQPTIKWFWHPCNHNHSEARCDFCSNNEESFILDADSN 497
+ G L C A G+P PTI W
Sbjct: 869 ITNE-----GVPASLPCVASGVPAPTITW------------------------------- 892
Query: 498 MGNRIESITQRMAIIEGKNKMASTLVVADSRISGIYICIASNKVGTVGRNISFYITDVP- 556
++T R + + ++ +G Y+C A+N VG + + + P
Sbjct: 893 -TKETNALTSRGPHYNVSKEGTLLIAQPSAQDAGAYVCTATNTVGFSSQEMRLSVNTKPR 951
Query: 557 ---NG---FHVNLEKMPTEGEDLKLSCTVNKFLYRDVTWILLRTVNNRTMHYSISKQKMA 610
NG +V L+ GE++ L C VTW S+
Sbjct: 952 IHMNGSRNANVPLQVTAKAGEEVTLDCEAKGSPPPLVTWT------------KDSRPVPP 999
Query: 611 ITKEHSI--TLNLTIMNVSLQDSGTYACRARN 640
IT + + + +L + V + DSG Y C A N
Sbjct: 1000 ITNRYGLLPSGSLRLAQVQVGDSGHYECTASN 1031
Score = 61.6 bits (148), Expect = 2e-09
Identities = 97/399 (24%), Positives = 143/399 (35%), Gaps = 79/399 (19%)
Query: 248 LVLNCTATTPLNTRVQMTWSYPDEKNKRASVRRRIDQSNSHANIFYSVLTIDKMQNKDKG 307
L+++C+ + L R+Q+ R R +S N + +L K + +G
Sbjct: 327 LLVSCSVHSALPFRLQLR-----RGEARLGEERHFQESG---NSSWEILRASKAE---EG 375
Query: 308 LYTCRVRSGPSFKSVNTSVHIYDKAFITVKHRKQQVLE----TVAGKRSYRLSMKVKAFP 363
Y C S KA I V Q++ TV+ + LS +V
Sbjct: 376 TYECTAVSRAGTGRA--------KAQIVVTDPPPQLVPAPNVTVSPGETAVLSCRVLGEA 427
Query: 364 SPEVVWLKDG--LPATEKSARYLTRGYSLIIKDVTEEDAGNYTILLSIKQSNVFKNLTAT 421
+ W++D LPA+ L SL I + D G Y + S +N +
Sbjct: 428 PYNLTWVRDWRVLPASTGRVAQLA-DLSLEISGIIPTDGGRYQCVAS--NANGVTRASVW 484
Query: 422 LIVNVKPQIYEKAVSSFPDPALYPLGSRQILTCTAYGIPQPTIKWFWHPCNHNHSEARCD 481
L+V PQ VS + G ++C+A G P P I W
Sbjct: 485 LLVREAPQ-----VSIHTSSQHFSQGVEVKVSCSASGYPTPHISW--------------- 524
Query: 482 FCSNNEESFILDADSNMGNRIESITQRMAIIEGKNKMASTLVVADSRISGIYICIASNKV 541
+ ES L DS RI Q II+G +G Y C A+N+V
Sbjct: 525 ----SRESQALQEDS----RIHVDAQGTLIIQG----------VAPEDAGNYSCQATNEV 566
Query: 542 GTVGRNISFYITDVPNGFHVNLEKMPTEGEDLKLSCTVNKFLYRDVTWILLRTVNNRTMH 601
GT ++ Y TD P+ VN + GE+ L C + V W
Sbjct: 567 GTDQETVTLYYTDPPSVSAVNAVVLVAVGEEAVLVCEASGVPPPRVIWYR---------- 616
Query: 602 YSISKQKMAITKEHSITLNLTIMNVSLQDSGTYACRARN 640
+M + E S + L I +D+GTY CRA N
Sbjct: 617 ---GGLEMILAPEGSSSGKLRIPAAQERDAGTYTCRAVN 652
Score = 60.8 bits (146), Expect = 4e-09
Identities = 66/338 (19%), Positives = 120/338 (35%), Gaps = 50/338 (14%)
Query: 305 DKGLYTCRVRSGPSFKSVNTSVHIYDKAFITVKHRKQQVLETVAGKRSYRLSMKVKAFPS 364
D G Y C + + + + + +++ Q + V K +S +P+
Sbjct: 464 DGGRYQCVASNANGVTRASVWLLVREAPQVSIHTSSQHFSQGVEVK----VSCSASGYPT 519
Query: 365 PEVVWLKDGLPATEKSARYLTRGYSLIIKDVTEEDAGNYTILLSIKQSNVFKNLTATLIV 424
P + W ++ E S ++ +LII+ V EDAGNY+ + + T TL
Sbjct: 520 PHISWSRESQALQEDSRIHVDAQGTLIIQGVAPEDAGNYSCQATNEVGT--DQETVTLYY 577
Query: 425 NVKPQIYEKAVSSFPDPALYPLGSRQILTCTAYGIPQPTIKWFWHPCNHNHSEARCDFCS 484
P +VS+ L +G +L C A G+P P + W+
Sbjct: 578 TDPP-----SVSAVNAVVLVAVGEEAVLVCEASGVPPPRVIWY----------------- 615
Query: 485 NNEESFILDADSNMGNRIESITQRMAIIEGKNKMASTLVVADSRISGIYICIASNKVGTV 544
+ + EG + + A R +G Y C A N++G
Sbjct: 616 ------------------RGGLEMILAPEGSSSGKLRIPAAQERDAGTYTCRAVNELGDA 657
Query: 545 GRNISFYITDVPNGFHVNLEKMPTEGEDLKLSCTVNKFLYRDVTWILLRTVNNRTMHYSI 604
I + P + + G L+C VTW R + + + +
Sbjct: 658 SAEIQLAVGHAPQLTELPRDVTVELGRSALLACRATGRPPPTVTW---RRGDGQPLGLRL 714
Query: 605 SKQKMAITKEHSITLNLTIMNVSLQDSGTYACRARNVY 642
+ + +++ + L +V+ +D Y C ARNV+
Sbjct: 715 GAGRGSRSRQPDSGV-LFFESVAPEDQAPYVCEARNVF 751
>gi|27262659 colony stimulating factor 1 receptor precursor [Homo
sapiens]
Length = 972
Score = 65.5 bits (158), Expect = 2e-10
Identities = 97/459 (21%), Positives = 186/459 (40%), Gaps = 66/459 (14%)
Query: 42 IMQAGQTLHLQCRGEAAHKWSLPEMVSKESERLSITKSACGRNGKQFCSTLTLNTAQANH 101
+++ G T+ L+C G + +W P S ++ S L+ N A +
Sbjct: 31 VVKPGATVTLRCVGNGSVEWDGPP-----SPHWTLYSDGSS-------SILSTNNATFQN 78
Query: 102 TGFYSCKYLAVPTSKKKETESAIYIFISDTGRPFVEMYSEIPEIIHMTEGRELVIPCRVT 161
TG Y C P +AI++++ D RP+ + E+ + E ++ ++PC +T
Sbjct: 79 TGTYRCTEPGDPLGGS----AAIHLYVKDPARPWNVLAQEVV----VFEDQDALLPCLLT 130
Query: 162 SPNIT--VTLKKFPLDTLIPDGKRIIWDSRKGFIISNATYKEIGLLTCEATVNGHLYKTN 219
P + V+L + L+ + GF I A + + C A + G +
Sbjct: 131 DPVLEAGVSLVRVRGRPLMRH-TNYSFSPWHGFTIHRAKFIQSQDYQCSALMGGRKVMSI 189
Query: 220 YLTHRQTNTIIDVQISTPRPVKL--LRGHTLVLNCTATTPLNTRVQMTWS-YPDEKNKRA 276
+ + I T P +L +RG + C+A++ V + + + N +
Sbjct: 190 SIRLKVQKVIPGPPALTLVPAELVRIRGEAAQIVCSASS-----VDVNFDVFLQHNNTKL 244
Query: 277 SVRRRIDQSNSHANIFYSVLTI--DKMQNKDKGLYTCRVRSGPSFKSVNTSVHIYDKAFI 334
++ + QS+ H N + VLT+ D++ + G Y+C + S + + + A++
Sbjct: 245 AIPQ---QSDFHNNRYQKVLTLNLDQVDFQHAGNYSCVASNVQGKHSTSMFFRVVESAYL 301
Query: 335 TVKHRKQQVLETVAGKRSYRLSMKVKAFPSPEVV-W-----LKDGLP------ATEKSAR 382
+ + + E G+ L + V+A+P + W D P AT K
Sbjct: 302 NLSSEQNLIQEVTVGE-GLNLKVMVEAYPGLQGFNWTYLGPFSDHQPEPKLANATTKDTY 360
Query: 383 YLTRGYSLIIKDVTEEDAGNYTILLSIKQSNVFKNLTATLIVNVKPQIYEKAVSSFPDPA 442
T ++L + + +AG Y+ L + ++ LT L + P++ + +F
Sbjct: 361 RHT--FTLSLPRLKPSEAGRYSFLA--RNPGGWRALTFELTLRYPPEV--SVIWTF---- 410
Query: 443 LYPLGSRQILTCTAYGIPQPTIKWFWHPCNHNHSEARCD 481
+ L C A G PQP + W C+ H++ RCD
Sbjct: 411 ---INGSGTLLCAASGYPQPNVTWL--QCS-GHTD-RCD 442
Score = 33.5 bits (75), Expect = 0.67
Identities = 40/170 (23%), Positives = 67/170 (39%), Gaps = 8/170 (4%)
Query: 477 EARCDFCSNNEESFILDADSNMGNRIESITQRMAIIEGKNKMASTLVV--ADSRISGIYI 534
EA CS + D N +I Q+ + + TL + D + +G Y
Sbjct: 218 EAAQIVCSASSVDVNFDVFLQHNNTKLAIPQQSDFHNNRYQKVLTLNLDQVDFQHAGNYS 277
Query: 535 CIASNKVGTVGRNISFYITD---VPNGFHVNLEKMPTEGEDLKLSCTVNKFL-YRDVTWI 590
C+ASN G ++ F + + + NL + T GE L L V + + W
Sbjct: 278 CVASNVQGKHSTSMFFRVVESAYLNLSSEQNLIQEVTVGEGLNLKVMVEAYPGLQGFNWT 337
Query: 591 LLRTVNNRTMHYSISKQKMAITKEHSITLNLTIMNVSLQDSGTYACRARN 640
L ++ ++ T H+ TL+L + S ++G Y+ ARN
Sbjct: 338 YLGPFSDHQPEPKLANATTKDTYRHTFTLSLPRLKPS--EAGRYSFLARN 385
>gi|126517478 peroxidasin homolog-like [Homo sapiens]
Length = 1463
Score = 65.5 bits (158), Expect = 2e-10
Identities = 87/401 (21%), Positives = 151/401 (37%), Gaps = 43/401 (10%)
Query: 30 KDPELSLKGTQHIMQAGQTLHLQCRGEAAHKWSLPEMVSKESERLSITKSACGRNGKQFC 89
+ P ++ + + +G T++ CR E K PE++ + S+ R
Sbjct: 232 QSPRITFEPQDVEVPSGNTVYFTCRAEGNPK---PEIIWIHNNH-SLDLEDDTRLNVFDD 287
Query: 90 STLTLNTAQANHTGFYSCKYLAVPTSKKKETESAIYIFISDTGRPFVEMYSEIPEIIHMT 149
TL + + + G Y C +A ++ + +T+SA+ + S +P + + E++
Sbjct: 288 GTLMIRNTRESDQGVYQC--MARNSAGEAKTQSAMLRYSSLPAKPSFVIQPQDTEVLI-- 343
Query: 150 EGRELVIPCRVTS---PNITVTLKKFPLDTLIPDGKRIIWDSRKGFIISNATYKEIGLLT 206
G + C T P IT T + L DG R + S G + N T ++ G T
Sbjct: 344 -GTSTTLECMATGHPHPLITWTRD----NGLELDGSRHVATS-SGLYLQNITQRDHGRFT 397
Query: 207 CEATVNGHLYKTNYLTHRQTNTIIDVQIS---TPRPVKLLRGHTLVLNCTATTPLNTRVQ 263
C A N H N I+ TP+ +L H + C A N
Sbjct: 398 CHAN-NSH-----GTVQAAANIIVQAPPQFTVTPKDQVVLEEHAVEWLCEADG--NPPPV 449
Query: 264 MTWSYPDEKNKRASVRRRIDQSNSHANIFYSVLTIDKMQNKDKGLYTCRVRSGPSFKSVN 323
+ W+ ++ H + L ID+ D+G Y C+ S K V+
Sbjct: 450 IVWT---------KTGGQLPVEGQHTVLSSGTLRIDRAAQHDQGQYECQAVSSLGVKKVS 500
Query: 324 TSVHIYDKAFITVKHRKQQVLETVAGKRSYRLSMKVKAFPSPEVVWLKDGLPATEKSARY 383
+ + KA Q V ++ +S + P P + W K+G+ TE +
Sbjct: 501 VQLTVKPKALAVFTQLPQDTSVEVG--KNINISCHAQGEPQPIITWNKEGVQITESGKFH 558
Query: 384 LTRGYSLIIKDVTEEDAGNYTIL----LSIKQSNVFKNLTA 420
+ +L I D D G Y + + +N+F +TA
Sbjct: 559 VDDEGTLTIYDAGFPDQGRYECVARNSFGLAVTNMFLTVTA 599
Score = 48.5 bits (114), Expect = 2e-05
Identities = 69/331 (20%), Positives = 119/331 (35%), Gaps = 33/331 (9%)
Query: 143 PEIIHMTEGRELVIPCRVTS---PNITVTLKKFPLDTLIPDGKRIIWDSRKGFIISNATY 199
P+ + + G + CR P I LD + D R+ +I N
Sbjct: 240 PQDVEVPSGNTVYFTCRAEGNPKPEIIWIHNNHSLD--LEDDTRLNVFDDGTLMIRNTRE 297
Query: 200 KEIGLLTCEATVNGHLYKTNYLTHRQTNTIIDVQ-ISTPRPVKLLRGHTLVLNCTATTPL 258
+ G+ C A + KT R ++ + P+ ++L G + L C AT
Sbjct: 298 SDQGVYQCMARNSAGEAKTQSAMLRYSSLPAKPSFVIQPQDTEVLIGTSTTLECMATG-- 355
Query: 259 NTRVQMTWSYPDEKNKRASVRRRIDQSNSHANIFYSVLTIDKMQNKDKGLYTCRVRSGPS 318
+ +TW+ + S R + S+ L + + +D G +TC +
Sbjct: 356 HPHPLITWTRDNGLELDGS--RHVATSSG--------LYLQNITQRDHGRFTCHANNSHG 405
Query: 319 FKSVNTSVHIYDKAFITVKHRKQQVLETVAGKRSYRLSMKVKAFPSPEVVWLKDGLPATE 378
++ + TV + Q VLE + + + P P +VW K G
Sbjct: 406 TVQAAANIIVQAPPQFTVTPKDQVVLE----EHAVEWLCEADGNPPPVIVWTKTGGQLPV 461
Query: 379 KSARYLTRGYSLIIKDVTEEDAGNYTILLSIKQSNVFKNLTATLIVNVKPQIYEKAVSSF 438
+ + +L I + D G Y ++ V K V+V+ + KA++ F
Sbjct: 462 EGQHTVLSSGTLRIDRAAQHDQGQYECQ-AVSSLGVKK-------VSVQLTVKPKALAVF 513
Query: 439 ---PDPALYPLGSRQILTCTAYGIPQPTIKW 466
P +G ++C A G PQP I W
Sbjct: 514 TQLPQDTSVEVGKNINISCHAQGEPQPIITW 544
Score = 47.8 bits (112), Expect = 3e-05
Identities = 84/427 (19%), Positives = 157/427 (36%), Gaps = 101/427 (23%)
Query: 237 PRPVKLLRGHTLVLNCTATTPLNTRVQMTWSYPDEKNKRASVRRRID-QSNSHANIFYS- 294
P+ V++ G+T+ C A N + ++ W + + +D + ++ N+F
Sbjct: 240 PQDVEVPSGNTVYFTCRAEG--NPKPEIIWIHNNHS---------LDLEDDTRLNVFDDG 288
Query: 295 VLTIDKMQNKDKGLYTCRVRSGPSFKSVNTSVHIYD----KAFITVKHRKQQVLETVAGK 350
L I + D+G+Y C R+ +++ Y K ++ + +VL
Sbjct: 289 TLMIRNTRESDQGVYQCMARNSAGEAKTQSAMLRYSSLPAKPSFVIQPQDTEVLIGT--- 345
Query: 351 RSYRLSMKVKAFPSPEVVWLKDGLPATEKSARYLTRGYSLIIKDVTEEDAGNYTILLSIK 410
S L P P + W +D + S R++ L ++++T+ D G +T +
Sbjct: 346 -STTLECMATGHPHPLITWTRDNGLELDGS-RHVATSSGLYLQNITQRDHGRFTCHANNS 403
Query: 411 QSNVFKNLTATLIVNVKPQ--IYEKAVSSFPDPALYPLGSRQILTCTAYGIPQPTIKWFW 468
V A +IV PQ + K + A+ L C A G P P I W
Sbjct: 404 HGTV--QAAANIIVQAPPQFTVTPKDQVVLEEHAVEWL-------CEADGNPPPVIVW-- 452
Query: 469 HPCNHNHSEARCDFCSNNEESFILDADSNMGNRIESITQRMAIIEGKNKMASTLVVADSR 528
+ G ++ +EG++ + S+ + R
Sbjct: 453 ---------------------------TKTGGQLP--------VEGQHTVLSSGTLRIDR 477
Query: 529 IS----GIYICIASNKVGTVGRNISFYITDVPNGFHVNLEKMPTE-----GEDLKLSCTV 579
+ G Y C A + +G + +S +T P V ++P + G+++ +SC
Sbjct: 478 AAQHDQGQYECQAVSSLGV--KKVSVQLTVKPKALAV-FTQLPQDTSVEVGKNINISCHA 534
Query: 580 NKFLYRDVTWILLRTVNNRTMHYSISKQKMAITKEHSITLN----LTIMNVSLQDSGTYA 635
+TW +K+ + IT+ ++ LTI + D G Y
Sbjct: 535 QGEPQPIITW---------------NKEGVQITESGKFHVDDEGTLTIYDAGFPDQGRYE 579
Query: 636 CRARNVY 642
C ARN +
Sbjct: 580 CVARNSF 586
>gi|20127422 Down syndrome cell adhesion molecule isoform CHD2-42
precursor [Homo sapiens]
Length = 2012
Score = 65.1 bits (157), Expect = 2e-10
Identities = 99/429 (23%), Positives = 165/429 (38%), Gaps = 71/429 (16%)
Query: 241 KLLRGHTLVLNCTATTPLNTRVQMTWSYPDEKNKRASVRRRIDQSNSHANIFYSVLTIDK 300
K +RG+ V C + + + + D + + R I + + L I
Sbjct: 134 KTMRGNVAVFKCIIPSSVEAYITVVSWEKDTVSLVSGSRFLITSTGA--------LYIKD 185
Query: 301 MQNKDKGLYTCRV-----RSGPSFKSVNTSVHIYDKAFITVK------HRKQQVLETVAG 349
+QN+D GLY R +G + +S + + + D A HRK +AG
Sbjct: 186 VQNED-GLYNYRCITRHRYTGETRQSNSARLFVSDPANSAPSILDGFDHRK-----AMAG 239
Query: 350 KRSYRLSMKVKAFPSPEVVWLKDGLPATEKSARYLTRGYSLIIKDVTEEDAGNYTILLSI 409
+R L K P P+ WLKD +P E S R+ L+I+++ D+G+Y +S
Sbjct: 240 QR-VELPCKALGHPEPDYRWLKDNMPL-ELSGRFQKTVTGLLIENIRPSDSGSYVCEVSN 297
Query: 410 KQSNVFKNLTATLIVNVKPQIYEKAVSSFPDPALYPLGSRQILTCTAYGIPQPTIKWFWH 469
+ TA +I + + KA S P +GS+ L+C+ G + W+
Sbjct: 298 RYG------TAKVIGRLYVKQPLKATIS-PRKVKSSVGSQVSLSCSVTGTEDQELSWY-- 348
Query: 470 PCNHNHSEARCDFCSNNEESFILDADSNMGNRIESITQRMAIIEGKNKMASTLVVADSRI 529
N E IL+ N+ R+ I +N + +V +D
Sbjct: 349 --------------RNGE---ILNPGKNV---------RITGINHENLIMDHMVKSDG-- 380
Query: 530 SGIYICIASNKVGTVGRNISFYITD-VPNGFHVNLEKMPTEGEDLKLSCTVNKFLYRDVT 588
G Y C + + + D P EK+ + E + L C V +T
Sbjct: 381 -GAYQCFVRKDKLSAQDYVQVVLEDGTPKIISAFSEKVVSPAEPVSLMCNVKGTPLPTIT 439
Query: 589 WILLRTVNNRTMHYSISKQKMAITKEHSITLNLTIMNVSLQDSGTYACRARNVYTGEEIL 648
W L + + IS+ IT E ++ L I + ++D G Y C A N + +L
Sbjct: 440 WTLDDDPILKGGSHRISQM---ITSEGNVVSYLNISSSQVRDGGVYRCTANN--SAGVVL 494
Query: 649 QKKEITIRG 657
+ I +RG
Sbjct: 495 YQARINVRG 503
Score = 59.7 bits (143), Expect = 9e-09
Identities = 78/332 (23%), Positives = 141/332 (42%), Gaps = 44/332 (13%)
Query: 151 GRELVIPCRVTSPNITVTLKKFPLDTLIPDGKRIIWDSRKGFIISNATYKEI--GLLTCE 208
GR+ I CRV ++K + L+P R + G + + KE+ G TC
Sbjct: 518 GRDTYIHCRVIGYPY-YSIKWYKNSNLLPFNHRQVAFENNGTLKLSDVQKEVDEGEYTCN 576
Query: 209 ATVNGHLYKTNYLTHRQTNTIIDVQISTP---RPVKLLR---GHTLVLNCTATTPLNTRV 262
V L T+ + V + P +P + R G + + C + + +
Sbjct: 577 VLVQPQL---------STSQSVHVTVKVPPFIQPFEFPRFSIGQRVFIPCVVVSG-DLPI 626
Query: 263 QMTWSYPDEKNKRASVRRRIDQSNSHANIFYSVLTIDKMQNKDKGLYTCRVRSGPSFKSV 322
+TW D + S+ ID + F S L I + G YTC R+ +
Sbjct: 627 TITWQ-KDGRPIPGSLGVTIDNID-----FTSSLRISNLSLMHNGNYTCIARNEAAAVEH 680
Query: 323 NTSVHIYDKAFITVKHRKQQVLETVAGKRSYRLSMKVKAFPSPEVVWLKD---GLPATEK 379
+ + + V+ R Q + + GK + L+ + +P P +VW G+P +
Sbjct: 681 QSQLIVRVPPKFVVQPRDQ---DGIYGK-AVILNCSAEGYPVPTIVWKFSKGAGVPQFQP 736
Query: 380 SA-----RYLTRGYSLIIKDVTEEDAGNYTILLSIKQSNVFKNLTATLIVNVKPQIYEKA 434
A + L+ G SL+IK V EED+G Y +S ++V +++ ++ + VK
Sbjct: 737 IALNGRIQVLSNG-SLLIKHVVEEDSGYYLCKVS---NDVGADVSKSMYLTVK---IPAM 789
Query: 435 VSSFPDPALYPLGSRQILTCTAYGIPQPTIKW 466
++S+P+ L G ++ ++CTA+G ++W
Sbjct: 790 ITSYPNTTLATQGQKKEMSCTAHGEKPIIVRW 821
Score = 58.9 bits (141), Expect = 1e-08
Identities = 90/361 (24%), Positives = 138/361 (38%), Gaps = 62/361 (17%)
Query: 299 DKMQNKDKGLYTCRVRSGPSFKSVNTSVHIYDKA--FITVKHRKQQVLETVAGKRSYRLS 356
D + D+G YTC V P S + SVH+ K FI + + G+R +
Sbjct: 563 DVQKEVDEGEYTCNVLVQPQL-STSQSVHVTVKVPPFI----QPFEFPRFSIGQRVFIPC 617
Query: 357 MKVKAFPSPEVVWLKDGLPATEKSARYLTR---GYSLIIKDVTEEDAGNYTILLSIKQSN 413
+ V + W KDG P + SL I +++ GNYT + + +
Sbjct: 618 VVVSGDLPITITWQKDGRPIPGSLGVTIDNIDFTSSLRISNLSLMHNGNYTCIARNEAAA 677
Query: 414 VFKNLTATLIVNVKPQIYEKAVSSFPDPALYPLGSRQILTCTAYGIPQPTIKWFWHPCNH 473
V + LIV V P+ V +Y G IL C+A G P PTI W
Sbjct: 678 VEHQ--SQLIVRVPPKF---VVQPRDQDGIY--GKAVILNCSAEGYPVPTIVW------- 723
Query: 474 NHSEARCDFCSNNEESFILDADSNMGNRIESITQRMAIIEGKNKMASTLVVADSRISGIY 533
F A I ++ R+ ++ + + +V DS G Y
Sbjct: 724 ---------------KFSKGAGVPQFQPI-ALNGRIQVLSNGSLLIKHVVEEDS---GYY 764
Query: 534 ICIASNKVGT-------VGRNISFYITDVPNGFHVNLEKMPTEGEDLKLSCTVNKFLYRD 586
+C SN VG + I IT PN + T+G+ ++SCT +
Sbjct: 765 LCKVSNDVGADVSKSMYLTVKIPAMITSYPN------TTLATQGQKKEMSCTAHGEKPII 818
Query: 587 VTWILL-RTVNNRTMHYSISKQKMAITKEHSITLNLTIMNVSLQDSGTYACRARNVYTGE 645
V W R +N Y +S +++ + L I+ +DSG ++C A N Y GE
Sbjct: 819 VRWEKEDRIINPEMARYLVSTKEVG----EEVISTLQILPTVREDSGFFSCHAINSY-GE 873
Query: 646 E 646
+
Sbjct: 874 D 874
Score = 32.0 bits (71), Expect = 2.0
Identities = 21/56 (37%), Positives = 28/56 (50%), Gaps = 4/56 (7%)
Query: 355 LSMKVKAFPSPEVVWLKD--GLPA--TEKSARYLTRGYSLIIKDVTEEDAGNYTIL 406
L K PSP V W+KD G P+ T R + S II+ V ED+G Y+ +
Sbjct: 1305 LPCKAVGDPSPAVKWMKDSNGTPSLVTIDGRRSIFSNGSFIIRTVKAEDSGYYSCI 1360
Score = 31.2 bits (69), Expect = 3.3
Identities = 30/122 (24%), Positives = 44/122 (36%), Gaps = 30/122 (24%)
Query: 423 IVNVKPQIYEKA-VSSFPDPALYPLGSRQILTCTAYGIPQPTIKWFWHPCNHNHSEARCD 481
I+ V+P A + +F P +L C A G P P +KW
Sbjct: 1275 IITVEPLAKAPARILTFSGTVTTPWMKDIVLPCKAVGDPSPAVKWM-------------- 1320
Query: 482 FCSNNEESFILDADSNMGNRIESITQRMAIIEGKNKMASTLVVADSRISGIYICIASNKV 541
DSN + +I R +I + + T+ D SG Y CIA+N
Sbjct: 1321 ------------KDSNGTPSLVTIDGRRSIFSNGSFIIRTVKAED---SGYYSCIANNNW 1365
Query: 542 GT 543
G+
Sbjct: 1366 GS 1367
>gi|19743806 roundabout 1 isoform b [Homo sapiens]
Length = 1612
Score = 63.9 bits (154), Expect = 5e-10
Identities = 90/421 (21%), Positives = 153/421 (36%), Gaps = 71/421 (16%)
Query: 234 ISTPRPVKLLRGHTLVLNCTATTPLNTRVQMTWSYPDEKNKRASVRRRIDQSNSH----- 288
+ P + + +G LNC A ++ W E+ V D SH
Sbjct: 32 VEHPSDLIVSKGEPATLNCKAEGRPTPTIE--WYKGGER-----VETDKDDPRSHRMLLP 84
Query: 289 -ANIFYSVLTIDKMQNKDKGLYTCRVRS--GPSFKSVNTSVHIYDKAFITVKHRKQQVLE 345
++F+ + + D+G+Y C R+ G + S N S+ + A + R+
Sbjct: 85 SGSLFFLRIVHGRKSRPDEGVYVCVARNYLGEAV-SHNASLEV---AILRDDFRQNPSDV 140
Query: 346 TVA-GKRSYRLSMKVKAFPSPEVVWLKDGLPATEKSARYLTRGYSLIIKDVTEEDAGNY- 403
VA G+ + + P P + W KDG P +K R RG L+I + DAG Y
Sbjct: 141 MVAVGEPAVMECQPPRGHPEPTISWKKDGSPLDDKDERITIRGGKLMITYTRKSDAGKYV 200
Query: 404 ---TILLSIKQSNVFKNLTATLIVNVKPQIYEKAVSSFPDPALYPLGSRQILTCTAYGIP 460
T ++ ++S V A L V +P ++ P + C A G P
Sbjct: 201 CVGTNMVGERESEV-----AELTVLERPSFVKR-----PSNLAVTVDDSAEFKCEARGDP 250
Query: 461 QPTIKWFWHPCNHNHSEARCDFCSNNEESFILDADSNMGNRIESITQRMAIIEGKNKMAS 520
PT++W R D + + + D + +I +T
Sbjct: 251 VPTVRW------------RKDDGELPKSRYEIRDDHTL--KIRKVT-------------- 282
Query: 521 TLVVADSRISGIYICIASNKVGTVGRNISFYITDVPNGFHVNLEKMPTEGEDLKLSCTVN 580
+ G Y C+A N VG + + + + P+ +++ G + C
Sbjct: 283 ------AGDMGSYTCVAENMVGKAEASATLTVQEPPHFVVKPRDQVVALGRTVTFQCEAT 336
Query: 581 KFLYRDVTWILLRTVNNRTMHYSISKQKMAITKEHSITLNLTIMNVSLQDSGTYACRARN 640
+ W R ++ + +S + + S T +LTI NV D G Y C+ N
Sbjct: 337 GNPQPAIFW---RREGSQNLLFSYQPPQSSSRFSVSQTGDLTITNVQRSDVGYYICQTLN 393
Query: 641 V 641
V
Sbjct: 394 V 394
Score = 48.9 bits (115), Expect = 2e-05
Identities = 79/318 (24%), Positives = 124/318 (38%), Gaps = 43/318 (13%)
Query: 108 KYLAVPTSKKKETESAIYIFISDTGRPFVEMYSEIPEIIHMTEGRELVIPCRVTSPNITV 167
KY+ V T+ E ES + FV+ S + + + + E R P TV
Sbjct: 198 KYVCVGTNMVGERESEVAELTVLERPSFVKRPSNLA--VTVDDSAEFKCEAR-GDPVPTV 254
Query: 168 TLKKFPLDTLIPDGKRIIWDSRKGFIISNATYKEIGLLTCEATVNGHLYKTNYLTHRQTN 227
+K D +P + I D I T ++G TC A N + + +
Sbjct: 255 RWRKD--DGELPKSRYEIRDDHT-LKIRKVTAGDMGSYTCVAE--------NMVGKAEAS 303
Query: 228 TIIDVQ-----ISTPRPVKLLRGHTLVLNCTATTPLNTRVQMTWSYPDEKNKRASVRRRI 282
+ VQ + PR + G T+ C AT N + + W +N S +
Sbjct: 304 ATLTVQEPPHFVVKPRDQVVALGRTVTFQCEATG--NPQPAIFWRREGSQNLLFSYQP-- 359
Query: 283 DQSNSHANIFYSV-LTIDKMQNKDKGLYTCRVRSGPSFKSVNTSVHIYDKAFITVKH--- 338
QS+S ++ + LTI +Q D G Y C+ ++N + I KA++ V
Sbjct: 360 PQSSSRFSVSQTGDLTITNVQRSDVGYYICQ--------TLNVAGSIITKAYLEVTDVIA 411
Query: 339 -------RKQQVLETVAGKRSYRLSMKVKAFPSPEVVWLKDG-LPATEKSARYLTRGYSL 390
R+ V +TVA ++ LS P P ++W KDG L +T+ S L
Sbjct: 412 DRPPPVIRQGPVNQTVAVDGTFVLSCVATGSPVPTILWRKDGVLVSTQDSRIKQLENGVL 471
Query: 391 IIKDVTEEDAGNYTILLS 408
I+ D G YT + S
Sbjct: 472 QIRYAKLGDTGRYTCIAS 489
Score = 43.9 bits (102), Expect = 5e-04
Identities = 98/474 (20%), Positives = 162/474 (34%), Gaps = 74/474 (15%)
Query: 25 SGSKLKDPELSLKGTQH----IMQAGQTLHLQCRGEAAHKWSLPEMVSKESERLSITKSA 80
SGS+L+ + + +H I+ G+ L C+ E ++ K ER+ K
Sbjct: 18 SGSRLRQEDFPPRIVEHPSDLIVSKGEPATLNCKAEGRPTPTIEWY--KGGERVETDKDD 75
Query: 81 CGRN------GKQFCSTLTLNTAQANHTGFYSC---KYLAVPTSKKKETESAIYIFISDT 131
+ G F + G Y C YL S E AI
Sbjct: 76 PRSHRMLLPSGSLFFLRIVHGRKSRPDEGVYVCVARNYLGEAVSHNASLEVAI------- 128
Query: 132 GRPFVEMYSEIPEIIHMTEGRELVIPCRVTS--PNITVTLKK--FPLDT-----LIPDGK 182
+ + + P + + G V+ C+ P T++ KK PLD I GK
Sbjct: 129 ---LRDDFRQNPSDVMVAVGEPAVMECQPPRGHPEPTISWKKDGSPLDDKDERITIRGGK 185
Query: 183 RIIWDSRKGFIISNATYKEIGLLTCEATVNGHLYKTNYLTHRQTNTIIDVQISTPRPVKL 242
+I +RK + G C T N + R++ + P VK
Sbjct: 186 LMITYTRKS---------DAGKYVCVGT--------NMVGERESEVAELTVLERPSFVKR 228
Query: 243 LRGHTLVLNCTATTPLNTRVQMTWSYPDEKNKRASVRRRIDQSNSHANIFYSVLTIDKMQ 302
+ ++ +A R + K+ + R + + H L I K+
Sbjct: 229 PSNLAVTVDDSAEFKCEARGDPVPTVRWRKDDGELPKSRYEIRDDHT------LKIRKVT 282
Query: 303 NKDKGLYTCRVRSGPSFKSVNTSVHIYDKAFITVKHRKQQVLETVAGKRSYRLSMKVKAF 362
D G YTC + + ++ + + VK R Q VA R+ +
Sbjct: 283 AGDMGSYTCVAENMVGKAEASATLTVQEPPHFVVKPRDQ----VVALGRTVTFQCEATGN 338
Query: 363 PSPEVVWLKDGL--------PATEKSARYLTRGYSLIIKDVTEEDAGNYTI-LLSIKQSN 413
P P + W ++G P S +++ L I +V D G Y L++ S
Sbjct: 339 PQPAIFWRREGSQNLLFSYQPPQSSSRFSVSQTGDLTITNVQRSDVGYYICQTLNVAGSI 398
Query: 414 VFKN-LTATLIVNVKPQIYEKAVSSFPDPALYPLGSRQILTCTAYGIPQPTIKW 466
+ K L T ++ +P + P + +L+C A G P PTI W
Sbjct: 399 ITKAYLEVTDVIADRPP---PVIRQGPVNQTVAVDGTFVLSCVATGSPVPTILW 449
Database: hs.faa
Posted date: Aug 4, 2009 4:42 PM
Number of letters in database: 18,247,518
Number of sequences in database: 37,866
Lambda K H
0.318 0.132 0.390
Gapped
Lambda K H
0.267 0.0410 0.140
Matrix: BLOSUM62
Gap Penalties: Existence: 11, Extension: 1
Number of Hits to DB: 25,079,220
Number of Sequences: 37866
Number of extensions: 1101786
Number of successful extensions: 7182
Number of sequences better than 10.0: 30
Number of HSP's better than 10.0 without gapping: 110
Number of HSP's successfully gapped in prelim test: 191
Number of HSP's that attempted gapping in prelim test: 3681
Number of HSP's gapped (non-prelim): 2642
length of query: 687
length of database: 18,247,518
effective HSP length: 109
effective length of query: 578
effective length of database: 14,120,124
effective search space: 8161431672
effective search space used: 8161431672
T: 11
A: 40
X1: 16 ( 7.3 bits)
X2: 38 (14.6 bits)
X3: 64 (24.7 bits)
S1: 41 (21.8 bits)
S2: 65 (29.6 bits)
Search results were obtained with NCBI BLAST and RefSeq entries.
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Guide to the Human Genome
Copyright © 2010 by Stewart Scherer. All rights reserved.