Guide to the Human Genome
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Search of human proteins with 22758144

BLASTP 2.2.11 [Jun-05-2005]


Reference: Altschul, Stephen F., Thomas L. Madden, Alejandro A. Schaffer, 
Jinghui Zhang, Zheng Zhang, Webb Miller, and David J. Lipman (1997), 
"Gapped BLAST and PSI-BLAST: a new generation of protein database search
programs",  Nucleic Acids Res. 25:3389-3402.

Query= gi|22758144 NADP-dependent retinol dehydrogenase/reductase
[Homo sapiens]
         (319 letters)

Database: hs.faa 
           37,866 sequences; 18,247,518 total letters

Searching..................................................done

                                                                 Score    E
Sequences producing significant alignments:                      (bits) Value

gi|40548397 NADP-dependent retinol dehydrogenase/reductase [Homo...   645   0.0  
gi|214010158 NADP-dependent retinol dehydrogenase/reductase [Hom...   645   0.0  
gi|214010156 NADP-dependent retinol dehydrogenase/reductase [Hom...   645   0.0  
gi|22758144 NADP-dependent retinol dehydrogenase/reductase [Homo...   645   0.0  
gi|19743808 hydroxysteroid (17-beta) dehydrogenase 6 [Homo sapiens]   296   2e-80
gi|150247226 retinol dehydrogenase 16 [Homo sapiens]                  295   4e-80
gi|22507405 short chain dehydrogenase/reductase family 9C, membe...   284   8e-77
gi|50726952 retinol dehydrogenase 5 (11-cis and 9-cis) [Homo sap...   274   7e-74
gi|44680136 3-hydroxybutyrate dehydrogenase, type 1 precursor [H...   188   5e-48
gi|44680133 3-hydroxybutyrate dehydrogenase, type 1 precursor [H...   188   5e-48
gi|17738292 3-hydroxybutyrate dehydrogenase, type 1 precursor [H...   188   5e-48
gi|4504503 hydroxysteroid (17-beta) dehydrogenase 2 [Homo sapiens]    169   3e-42
gi|119392083 hydroxysteroid (11-beta) dehydrogenase 2 [Homo sapi...   153   2e-37
gi|59889578 dehydrogenase/reductase (SDR family) member 10 [Homo...    86   4e-17
gi|20149619 dehydrogenase/reductase (SDR family) member 7B [Homo...    82   5e-16
gi|7657478 retinol dehydrogenase 8 (all-trans) [Homo sapiens]          80   3e-15
gi|7706318 dehydrogenase/reductase (SDR family) member 7 [Homo s...    77   2e-14
gi|142976729 estradiol 17-beta-dehydrogenase 11 [Homo sapiens]         67   2e-11
gi|223718074 hydroxysteroid (17-beta) dehydrogenase 1 [Homo sapi...    67   3e-11
gi|186928839 retinol dehydrogenase 12 [Homo sapiens]                   65   1e-10
gi|157739938 dehydrogenase/reductase (SDR family) member 7C [Hom...    65   1e-10
gi|109715829 short-chain dehydrogenase/reductase [Homo sapiens]        64   2e-10
gi|210032110 hydroxysteroid (17-beta) dehydrogenase 13 isoform A...    62   9e-10
gi|4758504 hydroxysteroid (17-beta) dehydrogenase 10 isoform 1 [...    59   4e-09
gi|32455239 11-beta-hydroxysteroid dehydrogenase 1 [Homo sapiens]      59   4e-09
gi|5031765 11-beta-hydroxysteroid dehydrogenase 1 [Homo sapiens]       59   4e-09
gi|166795268 retinol dehydrogenase 11 [Homo sapiens]                   59   4e-09
gi|225579078 retinol dehydrogenase 13 isoform 1 [Homo sapiens]         59   6e-09
gi|40254992 carbonic reductase 4 [Homo sapiens]                        57   2e-08
gi|33667109 dehydrogenase/reductase member 2 isoform 1 [Homo sap...    55   6e-08

>gi|40548397 NADP-dependent retinol dehydrogenase/reductase [Homo
           sapiens]
          Length = 319

 Score =  645 bits (1663), Expect = 0.0
 Identities = 319/319 (100%), Positives = 319/319 (100%)

Query: 1   MLFWVLGLLILCGFLWTRKGKLKIEDITDKYIFITGCDSGFGNLAARTFDKKGFHVIAAC 60
           MLFWVLGLLILCGFLWTRKGKLKIEDITDKYIFITGCDSGFGNLAARTFDKKGFHVIAAC
Sbjct: 1   MLFWVLGLLILCGFLWTRKGKLKIEDITDKYIFITGCDSGFGNLAARTFDKKGFHVIAAC 60

Query: 61  LTESGSTALKAETSERLRTVLLDVTDPENVKRTAQWVKNQVGEKGLWGLINNAGVPGVLA 120
           LTESGSTALKAETSERLRTVLLDVTDPENVKRTAQWVKNQVGEKGLWGLINNAGVPGVLA
Sbjct: 61  LTESGSTALKAETSERLRTVLLDVTDPENVKRTAQWVKNQVGEKGLWGLINNAGVPGVLA 120

Query: 121 PTDWLTLEDYREPIEVNLFGLISVTLNMLPLVKKAQGRVINVSSVGGRLAIVGGGYTPSK 180
           PTDWLTLEDYREPIEVNLFGLISVTLNMLPLVKKAQGRVINVSSVGGRLAIVGGGYTPSK
Sbjct: 121 PTDWLTLEDYREPIEVNLFGLISVTLNMLPLVKKAQGRVINVSSVGGRLAIVGGGYTPSK 180

Query: 181 YAVEGFNDSLRRDMKAFGVHVSCIEPGLFKTNLADPVKVIEKKLAIWEQLSPDIKQQYGE 240
           YAVEGFNDSLRRDMKAFGVHVSCIEPGLFKTNLADPVKVIEKKLAIWEQLSPDIKQQYGE
Sbjct: 181 YAVEGFNDSLRRDMKAFGVHVSCIEPGLFKTNLADPVKVIEKKLAIWEQLSPDIKQQYGE 240

Query: 241 GYIEKSLDKLKGNKSYVNMDLSPVVECMDHALTSLFPKTHYAAGKDAKIFWIPLSHMPAA 300
           GYIEKSLDKLKGNKSYVNMDLSPVVECMDHALTSLFPKTHYAAGKDAKIFWIPLSHMPAA
Sbjct: 241 GYIEKSLDKLKGNKSYVNMDLSPVVECMDHALTSLFPKTHYAAGKDAKIFWIPLSHMPAA 300

Query: 301 LQDFLLLKQKAELANPKAV 319
           LQDFLLLKQKAELANPKAV
Sbjct: 301 LQDFLLLKQKAELANPKAV 319


>gi|214010158 NADP-dependent retinol dehydrogenase/reductase [Homo
           sapiens]
          Length = 319

 Score =  645 bits (1663), Expect = 0.0
 Identities = 319/319 (100%), Positives = 319/319 (100%)

Query: 1   MLFWVLGLLILCGFLWTRKGKLKIEDITDKYIFITGCDSGFGNLAARTFDKKGFHVIAAC 60
           MLFWVLGLLILCGFLWTRKGKLKIEDITDKYIFITGCDSGFGNLAARTFDKKGFHVIAAC
Sbjct: 1   MLFWVLGLLILCGFLWTRKGKLKIEDITDKYIFITGCDSGFGNLAARTFDKKGFHVIAAC 60

Query: 61  LTESGSTALKAETSERLRTVLLDVTDPENVKRTAQWVKNQVGEKGLWGLINNAGVPGVLA 120
           LTESGSTALKAETSERLRTVLLDVTDPENVKRTAQWVKNQVGEKGLWGLINNAGVPGVLA
Sbjct: 61  LTESGSTALKAETSERLRTVLLDVTDPENVKRTAQWVKNQVGEKGLWGLINNAGVPGVLA 120

Query: 121 PTDWLTLEDYREPIEVNLFGLISVTLNMLPLVKKAQGRVINVSSVGGRLAIVGGGYTPSK 180
           PTDWLTLEDYREPIEVNLFGLISVTLNMLPLVKKAQGRVINVSSVGGRLAIVGGGYTPSK
Sbjct: 121 PTDWLTLEDYREPIEVNLFGLISVTLNMLPLVKKAQGRVINVSSVGGRLAIVGGGYTPSK 180

Query: 181 YAVEGFNDSLRRDMKAFGVHVSCIEPGLFKTNLADPVKVIEKKLAIWEQLSPDIKQQYGE 240
           YAVEGFNDSLRRDMKAFGVHVSCIEPGLFKTNLADPVKVIEKKLAIWEQLSPDIKQQYGE
Sbjct: 181 YAVEGFNDSLRRDMKAFGVHVSCIEPGLFKTNLADPVKVIEKKLAIWEQLSPDIKQQYGE 240

Query: 241 GYIEKSLDKLKGNKSYVNMDLSPVVECMDHALTSLFPKTHYAAGKDAKIFWIPLSHMPAA 300
           GYIEKSLDKLKGNKSYVNMDLSPVVECMDHALTSLFPKTHYAAGKDAKIFWIPLSHMPAA
Sbjct: 241 GYIEKSLDKLKGNKSYVNMDLSPVVECMDHALTSLFPKTHYAAGKDAKIFWIPLSHMPAA 300

Query: 301 LQDFLLLKQKAELANPKAV 319
           LQDFLLLKQKAELANPKAV
Sbjct: 301 LQDFLLLKQKAELANPKAV 319


>gi|214010156 NADP-dependent retinol dehydrogenase/reductase [Homo
           sapiens]
          Length = 319

 Score =  645 bits (1663), Expect = 0.0
 Identities = 319/319 (100%), Positives = 319/319 (100%)

Query: 1   MLFWVLGLLILCGFLWTRKGKLKIEDITDKYIFITGCDSGFGNLAARTFDKKGFHVIAAC 60
           MLFWVLGLLILCGFLWTRKGKLKIEDITDKYIFITGCDSGFGNLAARTFDKKGFHVIAAC
Sbjct: 1   MLFWVLGLLILCGFLWTRKGKLKIEDITDKYIFITGCDSGFGNLAARTFDKKGFHVIAAC 60

Query: 61  LTESGSTALKAETSERLRTVLLDVTDPENVKRTAQWVKNQVGEKGLWGLINNAGVPGVLA 120
           LTESGSTALKAETSERLRTVLLDVTDPENVKRTAQWVKNQVGEKGLWGLINNAGVPGVLA
Sbjct: 61  LTESGSTALKAETSERLRTVLLDVTDPENVKRTAQWVKNQVGEKGLWGLINNAGVPGVLA 120

Query: 121 PTDWLTLEDYREPIEVNLFGLISVTLNMLPLVKKAQGRVINVSSVGGRLAIVGGGYTPSK 180
           PTDWLTLEDYREPIEVNLFGLISVTLNMLPLVKKAQGRVINVSSVGGRLAIVGGGYTPSK
Sbjct: 121 PTDWLTLEDYREPIEVNLFGLISVTLNMLPLVKKAQGRVINVSSVGGRLAIVGGGYTPSK 180

Query: 181 YAVEGFNDSLRRDMKAFGVHVSCIEPGLFKTNLADPVKVIEKKLAIWEQLSPDIKQQYGE 240
           YAVEGFNDSLRRDMKAFGVHVSCIEPGLFKTNLADPVKVIEKKLAIWEQLSPDIKQQYGE
Sbjct: 181 YAVEGFNDSLRRDMKAFGVHVSCIEPGLFKTNLADPVKVIEKKLAIWEQLSPDIKQQYGE 240

Query: 241 GYIEKSLDKLKGNKSYVNMDLSPVVECMDHALTSLFPKTHYAAGKDAKIFWIPLSHMPAA 300
           GYIEKSLDKLKGNKSYVNMDLSPVVECMDHALTSLFPKTHYAAGKDAKIFWIPLSHMPAA
Sbjct: 241 GYIEKSLDKLKGNKSYVNMDLSPVVECMDHALTSLFPKTHYAAGKDAKIFWIPLSHMPAA 300

Query: 301 LQDFLLLKQKAELANPKAV 319
           LQDFLLLKQKAELANPKAV
Sbjct: 301 LQDFLLLKQKAELANPKAV 319


>gi|22758144 NADP-dependent retinol dehydrogenase/reductase [Homo
           sapiens]
          Length = 319

 Score =  645 bits (1663), Expect = 0.0
 Identities = 319/319 (100%), Positives = 319/319 (100%)

Query: 1   MLFWVLGLLILCGFLWTRKGKLKIEDITDKYIFITGCDSGFGNLAARTFDKKGFHVIAAC 60
           MLFWVLGLLILCGFLWTRKGKLKIEDITDKYIFITGCDSGFGNLAARTFDKKGFHVIAAC
Sbjct: 1   MLFWVLGLLILCGFLWTRKGKLKIEDITDKYIFITGCDSGFGNLAARTFDKKGFHVIAAC 60

Query: 61  LTESGSTALKAETSERLRTVLLDVTDPENVKRTAQWVKNQVGEKGLWGLINNAGVPGVLA 120
           LTESGSTALKAETSERLRTVLLDVTDPENVKRTAQWVKNQVGEKGLWGLINNAGVPGVLA
Sbjct: 61  LTESGSTALKAETSERLRTVLLDVTDPENVKRTAQWVKNQVGEKGLWGLINNAGVPGVLA 120

Query: 121 PTDWLTLEDYREPIEVNLFGLISVTLNMLPLVKKAQGRVINVSSVGGRLAIVGGGYTPSK 180
           PTDWLTLEDYREPIEVNLFGLISVTLNMLPLVKKAQGRVINVSSVGGRLAIVGGGYTPSK
Sbjct: 121 PTDWLTLEDYREPIEVNLFGLISVTLNMLPLVKKAQGRVINVSSVGGRLAIVGGGYTPSK 180

Query: 181 YAVEGFNDSLRRDMKAFGVHVSCIEPGLFKTNLADPVKVIEKKLAIWEQLSPDIKQQYGE 240
           YAVEGFNDSLRRDMKAFGVHVSCIEPGLFKTNLADPVKVIEKKLAIWEQLSPDIKQQYGE
Sbjct: 181 YAVEGFNDSLRRDMKAFGVHVSCIEPGLFKTNLADPVKVIEKKLAIWEQLSPDIKQQYGE 240

Query: 241 GYIEKSLDKLKGNKSYVNMDLSPVVECMDHALTSLFPKTHYAAGKDAKIFWIPLSHMPAA 300
           GYIEKSLDKLKGNKSYVNMDLSPVVECMDHALTSLFPKTHYAAGKDAKIFWIPLSHMPAA
Sbjct: 241 GYIEKSLDKLKGNKSYVNMDLSPVVECMDHALTSLFPKTHYAAGKDAKIFWIPLSHMPAA 300

Query: 301 LQDFLLLKQKAELANPKAV 319
           LQDFLLLKQKAELANPKAV
Sbjct: 301 LQDFLLLKQKAELANPKAV 319


>gi|19743808 hydroxysteroid (17-beta) dehydrogenase 6 [Homo sapiens]
          Length = 317

 Score =  296 bits (758), Expect = 2e-80
 Identities = 139/293 (47%), Positives = 204/293 (69%), Gaps = 1/293 (0%)

Query: 16  WTRKGKLKIEDITDKYIFITGCDSGFGNLAARTFDKKGFHVIAACLTESGSTALKAETSE 75
           W R+ ++ +  + DKY+FITGCDSGFGNL AR  D +G  V+AACLTE G+  L+ +TS+
Sbjct: 17  WYRERQV-VSHLQDKYVFITGCDSGFGNLLARQLDARGLRVLAACLTEKGAEQLRGQTSD 75

Query: 76  RLRTVLLDVTDPENVKRTAQWVKNQVGEKGLWGLINNAGVPGVLAPTDWLTLEDYREPIE 135
           RL TV LDVT  E++    QWVK  VG++GLWGL+NNAG+   +   +WL  ED    ++
Sbjct: 76  RLETVTLDVTKMESIAAATQWVKEHVGDRGLWGLVNNAGILTPITLCEWLNTEDSMNMLK 135

Query: 136 VNLFGLISVTLNMLPLVKKAQGRVINVSSVGGRLAIVGGGYTPSKYAVEGFNDSLRRDMK 195
           VNL G+I VTL+MLPLV++A+GR++NVSS+ GR+A   GGY  SKY VE F+D LRR+++
Sbjct: 136 VNLIGVIQVTLSMLPLVRRARGRIVNVSSILGRVAFFVGGYCVSKYGVEAFSDILRREIQ 195

Query: 196 AFGVHVSCIEPGLFKTNLADPVKVIEKKLAIWEQLSPDIKQQYGEGYIEKSLDKLKGNKS 255
            FGV +S +EPG F+T + +  + +E+    W++    IK+ YG+ Y +   + +K    
Sbjct: 196 HFGVKISIVEPGYFRTGMTNMTQSLERMKQSWKEAPKHIKETYGQQYFDALYNIMKEGLL 255

Query: 256 YVNMDLSPVVECMDHALTSLFPKTHYAAGKDAKIFWIPLSHMPAALQDFLLLK 308
             + +L+ V +CM+HALTS+ P+T Y+AG DAK F+IPLS++P +L D++L +
Sbjct: 256 NCSTNLNLVTDCMEHALTSVHPRTRYSAGWDAKFFFIPLSYLPTSLADYILTR 308


>gi|150247226 retinol dehydrogenase 16 [Homo sapiens]
          Length = 317

 Score =  295 bits (755), Expect = 4e-80
 Identities = 143/291 (49%), Positives = 202/291 (69%), Gaps = 1/291 (0%)

Query: 16  WTRKGKLKIEDITDKYIFITGCDSGFGNLAARTFDKKGFHVIAACLTESGSTALKAETSE 75
           W R+ ++ +  + DKY+FITGCDSGFG L AR  D +G  V+AACLTE G+  L+ +TS+
Sbjct: 17  WYRERQV-LSHLRDKYVFITGCDSGFGKLLARQLDARGLRVLAACLTEKGAEQLRGQTSD 75

Query: 76  RLRTVLLDVTDPENVKRTAQWVKNQVGEKGLWGLINNAGVPGVLAPTDWLTLEDYREPIE 135
           RL TV LDVT  E+V   AQWVK  V +KGLWGL+NNAG+    AP + LT +D+   ++
Sbjct: 76  RLETVTLDVTKTESVAAAAQWVKECVRDKGLWGLVNNAGISLPTAPNELLTKQDFVTILD 135

Query: 136 VNLFGLISVTLNMLPLVKKAQGRVINVSSVGGRLAIVGGGYTPSKYAVEGFNDSLRRDMK 195
           VNL G+I VTL++LPLV++A+GRV+NVSSV GR+++ GGGY  SKY VE F+DSLRR++ 
Sbjct: 136 VNLLGVIDVTLSLLPLVRRARGRVVNVSSVMGRVSLFGGGYCISKYGVEAFSDSLRRELS 195

Query: 196 AFGVHVSCIEPGLFKTNLADPVKVIEKKLAIWEQLSPDIKQQYGEGYIEKSLDKLKGNKS 255
            FGV V+ IEPG FKT +    + ++  L IW++ SP++K+ YGE ++       +  + 
Sbjct: 196 YFGVKVAMIEPGYFKTAVTSKERFLKSFLEIWDRSSPEVKEAYGEKFVADYKKSAEQMEQ 255

Query: 256 YVNMDLSPVVECMDHALTSLFPKTHYAAGKDAKIFWIPLSHMPAALQDFLL 306
               DLS V  CM+HAL +  P+T Y+AG DAK+ ++P+S+MP  L D ++
Sbjct: 256 KCTQDLSLVTNCMEHALIACHPRTRYSAGWDAKLLYLPMSYMPTFLVDAIM 306


>gi|22507405 short chain dehydrogenase/reductase family 9C, member 7
           [Homo sapiens]
          Length = 313

 Score =  284 bits (726), Expect = 8e-77
 Identities = 137/293 (46%), Positives = 196/293 (66%), Gaps = 1/293 (0%)

Query: 14  FLWTRKGKLKIEDITDKYIFITGCDSGFGNLAARTFDKKGFHVIAACLTESGSTALKAET 73
           + W +   L + ++++KY+FITGCDSGFGNL A+    +G  V+AAC TE GS  L+ +T
Sbjct: 11  YRWFKNCNL-VGNLSEKYVFITGCDSGFGNLLAKQLVDRGMQVLAACFTEEGSQKLQRDT 69

Query: 74  SERLRTVLLDVTDPENVKRTAQWVKNQVGEKGLWGLINNAGVPGVLAPTDWLTLEDYREP 133
           S RL+T LLDVT  E++K  AQWV+++VGE+GLW L+NNAGV     P +WLT +D+ + 
Sbjct: 70  SYRLQTTLLDVTKSESIKAAAQWVRDKVGEQGLWALVNNAGVGLPSGPNEWLTKDDFVKV 129

Query: 134 IEVNLFGLISVTLNMLPLVKKAQGRVINVSSVGGRLAIVGGGYTPSKYAVEGFNDSLRRD 193
           I VNL GLI VTL+MLP+VK+A+GRV+N+SS GGR+A++GGGY  SK+ VE F+DS+RR+
Sbjct: 130 INVNLVGLIEVTLHMLPMVKRARGRVVNMSSSGGRVAVIGGGYCVSKFGVEAFSDSIRRE 189

Query: 194 MKAFGVHVSCIEPGLFKTNLADPVKVIEKKLAIWEQLSPDIKQQYGEGYIEKSLDKLKGN 253
           +  FGV V  IEPG ++T +     +  +   +WE+L  + +  YGE Y     DKLK  
Sbjct: 190 LYYFGVKVCIIEPGNYRTAILGKENLESRMRKLWERLPQETRDSYGEDYFRIYTDKLKNI 249

Query: 254 KSYVNMDLSPVVECMDHALTSLFPKTHYAAGKDAKIFWIPLSHMPAALQDFLL 306
                  +  V+  M+HA+ S  P+  Y  G DAK+ +IPL+ +P  + DF+L
Sbjct: 250 MQVAEPRVRDVINSMEHAIVSRSPRIRYNPGLDAKLLYIPLAKLPTPVTDFIL 302


>gi|50726952 retinol dehydrogenase 5 (11-cis and 9-cis) [Homo
           sapiens]
          Length = 318

 Score =  274 bits (701), Expect = 7e-74
 Identities = 137/299 (45%), Positives = 205/299 (68%), Gaps = 4/299 (1%)

Query: 10  ILCGFLWTRKGKLKIEDITDKYIFITGCDSGFGNLAARTFDKKGFHVIAACLTESGSTAL 69
           +L   LW  + +  +   ++ ++FITGCDSGFG L A   D++GF V+A+CLT SG+  L
Sbjct: 10  LLWAVLWLLRDRQSLP-ASNAFVFITGCDSGFGRLLALQLDQRGFRVLASCLTPSGAEDL 68

Query: 70  KAETSERLRTVLLDVTDPENVKRTAQWVKNQVGEKGLWGLINNAGVPGVLAPTDWLTLED 129
           +   S RL T LLD+TDP++V++ A+WV+  V E GL+GL+NNAGV G++ PT WLT +D
Sbjct: 69  QRVASSRLHTTLLDITDPQSVQQAAKWVEMHVKEAGLFGLVNNAGVAGIIGPTPWLTRDD 128

Query: 130 YREPIEVNLFGLISVTLNMLPLVKKAQGRVINVSSVGGRLAIVGGGYTPSKYAVEGFNDS 189
           ++  + VN  G I VTL +LPL+++A+GRVIN++SV GRLA  GGGY  SK+ +E F+DS
Sbjct: 129 FQRVLNVNTMGPIGVTLALLPLLQQARGRVINITSVLGRLAANGGGYCVSKFGLEAFSDS 188

Query: 190 LRRDMKAFGVHVSCIEPGLFKTNLADPVKVIEKKL-AIWEQLSPDIKQQYGEGYIEKSLD 248
           LRRD+  FG+ VS +EPG F+T + + ++ +EK L A W +L P  +  YG  ++ K L 
Sbjct: 189 LRRDVAHFGIRVSIVEPGFFRTPVTN-LESLEKTLQACWARLPPATQAHYGGAFLTKYLK 247

Query: 249 KLKGNKSYV-NMDLSPVVECMDHALTSLFPKTHYAAGKDAKIFWIPLSHMPAALQDFLL 306
             +   + + + DL+ V  C++HALT+  P+T Y+ G DAK+ W+P S++PA+L D +L
Sbjct: 248 MQQRIMNLICDPDLTKVSRCLEHALTARHPRTRYSPGWDAKLLWLPASYLPASLVDAVL 306


>gi|44680136 3-hydroxybutyrate dehydrogenase, type 1 precursor [Homo
           sapiens]
          Length = 343

 Score =  188 bits (478), Expect = 5e-48
 Identities = 110/298 (36%), Positives = 177/298 (59%), Gaps = 19/298 (6%)

Query: 25  EDITDKYIFITGCDSGFGNLAARTFDKKGFHVIAACLTES----GSTALKAETSERLRTV 80
           E +  K + +TGCDSGFG   A+    KGF V A CL +     G   L +  S+RLRTV
Sbjct: 51  EPVGSKAVLVTGCDSGFGFSLAKHLHSKGFLVFAGCLMKDKGHDGVKELDSLNSDRLRTV 110

Query: 81  LLDVTDPENVKRTAQWVKNQVG--EKGLWGLINNAGVPGVLAPTDWLTLEDYREPIEVNL 138
            L+V   E V++  + V++ +   EKG+WGL+NNAG+       ++ +LE Y++  EVNL
Sbjct: 111 QLNVCSSEEVEKVVEIVRSSLKDPEKGMWGLVNNAGI-STFGEVEFTSLETYKQVAEVNL 169

Query: 139 FGLISVTLNMLPLVKKAQGRVINVSSVGGRLA-IVGGGYTPSKYAVEGFNDSLRRDMKAF 197
           +G + +T + LPL+++A+GRV+N+SS+ GR+A      Y  +K+ VE F+D LR +M   
Sbjct: 170 WGTVRMTKSFLPLIRRAKGRVVNISSMLGRMANPARSPYCITKFGVEAFSDCLRYEMYPL 229

Query: 198 GVHVSCIEPGLF--KTNLADP--VKVIEKKLAIWEQLSPDIKQQYGEGYIEKSLDKLKGN 253
           GV VS +EPG F   T+L  P  ++ I KK+  WE+L   +++ YG+ Y ++ + K++  
Sbjct: 230 GVKVSVVEPGNFIAATSLYSPESIQAIAKKM--WEELPEVVRKDYGKKYFDEKIAKMETY 287

Query: 254 KSYVNMDLSPVVECMDHALTSLFPKTHYAAGKDAKIFWIP---LSHMPAALQDFLLLK 308
            S  + D SPV++ + HALT+  P T Y        +W+    ++H+P A+ D + ++
Sbjct: 288 CSSGSTDTSPVIDAVTHALTATTPYTRYHPMD--YYWWLRMQIMTHLPGAISDMIYIR 343


>gi|44680133 3-hydroxybutyrate dehydrogenase, type 1 precursor [Homo
           sapiens]
          Length = 343

 Score =  188 bits (478), Expect = 5e-48
 Identities = 110/298 (36%), Positives = 177/298 (59%), Gaps = 19/298 (6%)

Query: 25  EDITDKYIFITGCDSGFGNLAARTFDKKGFHVIAACLTES----GSTALKAETSERLRTV 80
           E +  K + +TGCDSGFG   A+    KGF V A CL +     G   L +  S+RLRTV
Sbjct: 51  EPVGSKAVLVTGCDSGFGFSLAKHLHSKGFLVFAGCLMKDKGHDGVKELDSLNSDRLRTV 110

Query: 81  LLDVTDPENVKRTAQWVKNQVG--EKGLWGLINNAGVPGVLAPTDWLTLEDYREPIEVNL 138
            L+V   E V++  + V++ +   EKG+WGL+NNAG+       ++ +LE Y++  EVNL
Sbjct: 111 QLNVCSSEEVEKVVEIVRSSLKDPEKGMWGLVNNAGI-STFGEVEFTSLETYKQVAEVNL 169

Query: 139 FGLISVTLNMLPLVKKAQGRVINVSSVGGRLA-IVGGGYTPSKYAVEGFNDSLRRDMKAF 197
           +G + +T + LPL+++A+GRV+N+SS+ GR+A      Y  +K+ VE F+D LR +M   
Sbjct: 170 WGTVRMTKSFLPLIRRAKGRVVNISSMLGRMANPARSPYCITKFGVEAFSDCLRYEMYPL 229

Query: 198 GVHVSCIEPGLF--KTNLADP--VKVIEKKLAIWEQLSPDIKQQYGEGYIEKSLDKLKGN 253
           GV VS +EPG F   T+L  P  ++ I KK+  WE+L   +++ YG+ Y ++ + K++  
Sbjct: 230 GVKVSVVEPGNFIAATSLYSPESIQAIAKKM--WEELPEVVRKDYGKKYFDEKIAKMETY 287

Query: 254 KSYVNMDLSPVVECMDHALTSLFPKTHYAAGKDAKIFWIP---LSHMPAALQDFLLLK 308
            S  + D SPV++ + HALT+  P T Y        +W+    ++H+P A+ D + ++
Sbjct: 288 CSSGSTDTSPVIDAVTHALTATTPYTRYHPMD--YYWWLRMQIMTHLPGAISDMIYIR 343


>gi|17738292 3-hydroxybutyrate dehydrogenase, type 1 precursor [Homo
           sapiens]
          Length = 343

 Score =  188 bits (478), Expect = 5e-48
 Identities = 110/298 (36%), Positives = 177/298 (59%), Gaps = 19/298 (6%)

Query: 25  EDITDKYIFITGCDSGFGNLAARTFDKKGFHVIAACLTES----GSTALKAETSERLRTV 80
           E +  K + +TGCDSGFG   A+    KGF V A CL +     G   L +  S+RLRTV
Sbjct: 51  EPVGSKAVLVTGCDSGFGFSLAKHLHSKGFLVFAGCLMKDKGHDGVKELDSLNSDRLRTV 110

Query: 81  LLDVTDPENVKRTAQWVKNQVG--EKGLWGLINNAGVPGVLAPTDWLTLEDYREPIEVNL 138
            L+V   E V++  + V++ +   EKG+WGL+NNAG+       ++ +LE Y++  EVNL
Sbjct: 111 QLNVCSSEEVEKVVEIVRSSLKDPEKGMWGLVNNAGI-STFGEVEFTSLETYKQVAEVNL 169

Query: 139 FGLISVTLNMLPLVKKAQGRVINVSSVGGRLA-IVGGGYTPSKYAVEGFNDSLRRDMKAF 197
           +G + +T + LPL+++A+GRV+N+SS+ GR+A      Y  +K+ VE F+D LR +M   
Sbjct: 170 WGTVRMTKSFLPLIRRAKGRVVNISSMLGRMANPARSPYCITKFGVEAFSDCLRYEMYPL 229

Query: 198 GVHVSCIEPGLF--KTNLADP--VKVIEKKLAIWEQLSPDIKQQYGEGYIEKSLDKLKGN 253
           GV VS +EPG F   T+L  P  ++ I KK+  WE+L   +++ YG+ Y ++ + K++  
Sbjct: 230 GVKVSVVEPGNFIAATSLYSPESIQAIAKKM--WEELPEVVRKDYGKKYFDEKIAKMETY 287

Query: 254 KSYVNMDLSPVVECMDHALTSLFPKTHYAAGKDAKIFWIP---LSHMPAALQDFLLLK 308
            S  + D SPV++ + HALT+  P T Y        +W+    ++H+P A+ D + ++
Sbjct: 288 CSSGSTDTSPVIDAVTHALTATTPYTRYHPMD--YYWWLRMQIMTHLPGAISDMIYIR 343


>gi|4504503 hydroxysteroid (17-beta) dehydrogenase 2 [Homo sapiens]
          Length = 387

 Score =  169 bits (428), Expect = 3e-42
 Identities = 107/312 (34%), Positives = 169/312 (54%), Gaps = 15/312 (4%)

Query: 3   FWVLGLL-ILCGFLWTRKGKLKIEDITDKYIFITGCDSGFGNLAARTFDKKGFHVIAACL 61
           FW L L  + C  ++T     ++  +  K + +TG D G G+   +  D+ GF V A  L
Sbjct: 55  FWGLILFSVSCFLMYTYLSGQELLPVDQKAVLVTGGDCGLGHALCKYLDELGFTVFAGVL 114

Query: 62  TESGSTA--LKAETSERLRTVLLDVTDPENVKRTAQWVKNQVGEKGLWGLINNAGVPGVL 119
            E+G  A  L+   S RL  + +D+T P  +K     V   + ++GLW +INNAGV G  
Sbjct: 115 NENGPGAEELRRTCSPRLSVLQMDITKPVQIKDAYSKVAAMLQDRGLWAVINNAGVLGFP 174

Query: 120 APTDWLTLEDYREPIEVNLFGLISVTLNMLPLVKKAQGRVINVSSVGG-----RLAIVGG 174
              + L + DY++ + VN FG + VT   LPL++K++GR++NVSS+GG     RLA    
Sbjct: 175 TDGELLLMTDYKQCMAVNFFGTVEVTKTFLPLLRKSKGRLVNVSSMGGGAPMERLA---- 230

Query: 175 GYTPSKYAVEGFNDSLRRDMKAFGVHVSCIEPGLFKTNLADPVKVIEK-KLAIWEQLSPD 233
            Y  SK AV  F+  +R ++  +G+ V+ I+PG F TN+A      EK +  I + L  +
Sbjct: 231 SYGSSKAAVTMFSSVMRLELSKWGIKVASIQPGGFLTNIAGTSDKWEKLEKDILDHLPAE 290

Query: 234 IKQQYGEGYIEKSLDKLKGNKSYVNMDLSPVVECMDHALTSLFPKTHYAAGKDAKIFWIP 293
           +++ YG+ YI    + L    S  + D SPV+  + HA+ +  P  +Y  GK A + WI 
Sbjct: 291 VQEDYGQDYILAQRNFLLLINSLASKDFSPVLRDIQHAILAKSPFAYYTPGKGAYL-WIC 349

Query: 294 LSH-MPAALQDF 304
           L+H +P  + D+
Sbjct: 350 LAHYLPIGIYDY 361


>gi|119392083 hydroxysteroid (11-beta) dehydrogenase 2 [Homo
           sapiens]
          Length = 405

 Score =  153 bits (387), Expect = 2e-37
 Identities = 93/280 (33%), Positives = 146/280 (52%), Gaps = 4/280 (1%)

Query: 27  ITDKYIFITGCDSGFGNLAARTFDKKGFHVIAACLTESGSTALKAET--SERLRTVLLDV 84
           +  + + ITGCDSGFG   A+  D  GF V+A  L  +   A++  T  S RLR + +D+
Sbjct: 80  VATRAVLITGCDSGFGKETAKKLDSMGFTVLATVLELNSPGAIELRTCCSPRLRLLQMDL 139

Query: 85  TDPENVKRTAQWVKNQVGEKGLWGLINNAGVPGVLAPTDWLTLEDYREPIEVNLFGLISV 144
           T P ++ R  ++ K      GLWGL+NNAG   V+A  +   +  +R  +EVN FG + +
Sbjct: 140 TKPGDISRVLEFTKAHTTSTGLWGLVNNAGHNEVVADAELSPVATFRSCMEVNFFGALEL 199

Query: 145 TLNMLPLVKKAQGRVINVSSVGGRLAI-VGGGYTPSKYAVEGFNDSLRRDMKAFGVHVSC 203
           T  +LPL++ ++GR++ V S  G +     G Y  SK AV    D+   ++  +GV VS 
Sbjct: 200 TKGLLPLLRSSRGRIVTVGSPAGDMPYPCLGAYGTSKAAVALLMDTFSCELLPWGVKVSI 259

Query: 204 IEPGLFKTNLADPVKVIEK-KLAIWEQLSPDIKQQYGEGYIEKSLDKLKGNKSYVNMDLS 262
           I+PG FKT     V   EK K  +   L  ++ Q YG+ YIE    +   +      DL+
Sbjct: 260 IQPGCFKTESVRNVGQWEKRKQLLLANLPQELLQAYGKDYIEHLHGQFLHSLRLAMSDLT 319

Query: 263 PVVECMDHALTSLFPKTHYAAGKDAKIFWIPLSHMPAALQ 302
           PVV+ +  AL +  P+  Y  G+   + +    ++P  L+
Sbjct: 320 PVVDAITDALLAARPRRRYYPGQGLGLMYFIHYYLPEGLR 359


>gi|59889578 dehydrogenase/reductase (SDR family) member 10 [Homo
           sapiens]
          Length = 270

 Score = 85.9 bits (211), Expect = 4e-17
 Identities = 67/225 (29%), Positives = 106/225 (47%), Gaps = 20/225 (8%)

Query: 30  KYIFITGCDSGFGNLAARTFDKKGFHVIAACLTESGSTALKAETSERLRTVLLDVTDPEN 89
           K + +TG   G G    R F   G  V+     ESG  AL+ E    +  +L DVT  ++
Sbjct: 10  KVVVVTGGGRGIGAGIVRAFVNSGARVVICDKDESGGRALEQELPGAV-FILCDVTQEDD 68

Query: 90  VKRTAQWVKNQVGEKGLWGLINNAGVPGVLAPTDWLTLEDYREPIEVNLFGLISVTLNML 149
           VK        + G   L  ++NNAG        +  + + +R+ +E+NL G  ++T   L
Sbjct: 69  VKTLVSETIRRFGR--LDCVVNNAGHHPPPQRPEETSAQGFRQLLELNLLGTYTLTKLAL 126

Query: 150 PLVKKAQGRVINVSSVGGRLAIVGG-GYTPSKYAVEGFNDSLRRDMKAFGVHVSCIEPGL 208
           P ++K+QG VIN+SS+ G +       Y  +K AV     +L  D   +GV V+CI PG 
Sbjct: 127 PYLRKSQGNVINISSLVGAIGQAQAVPYVATKGAVTAMTKALALDESPYGVRVNCISPG- 185

Query: 209 FKTNLADPVKVIEKKLAIWEQLS---PDIKQQYGEGYIEKSLDKL 250
              N+  P         +WE+L+   PD +    EG + + L ++
Sbjct: 186 ---NIWTP---------LWEELAALMPDPRATIREGMLAQPLGRM 218


>gi|20149619 dehydrogenase/reductase (SDR family) member 7B [Homo
           sapiens]
          Length = 325

 Score = 82.4 bits (202), Expect = 5e-16
 Identities = 66/228 (28%), Positives = 113/228 (49%), Gaps = 23/228 (10%)

Query: 1   MLFWVLGLLILCGFLWTRKGKLKIEDITDKYIFITGCDSGFGNLAARTFDKKGFHVIAAC 60
           +LF  LG+  L   L   +GK  + +     + ITG  SG G   A+ F   G  ++  C
Sbjct: 27  LLFGCLGVFGLFRLLQWVRGKAYLRNAV---VVITGATSGLGKECAKVFYAAGAKLVL-C 82

Query: 61  LTESGSTA-----LKAETSERLRT-----VLLDVTDPENVKRTAQWVKNQVGEKGLWGLI 110
               G+       L A  + +++T     V  D+TD   +   A  +    G   +  L+
Sbjct: 83  GRNGGALEELIRELTASHATKVQTHKPYLVTFDLTDSGAIVAAAAEILQCFGYVDI--LV 140

Query: 111 NNAGVP--GVLAPTDWLTLEDYREPIEVNLFGLISVTLNMLP-LVKKAQGRVINVSSVGG 167
           NNAG+   G +  T   T++  +  +E N FG +++T  +LP ++K+ QG ++ +SS+ G
Sbjct: 141 NNAGISYRGTIMDT---TVDVDKRVMETNYFGPVALTKALLPSMIKRRQGHIVAISSIQG 197

Query: 168 RLAI-VGGGYTPSKYAVEGFNDSLRRDMKAFGVHVSCIEPGLFKTNLA 214
           +++I     Y  SK+A + F D LR +M+ + + V+ I PG   TNL+
Sbjct: 198 KMSIPFRSAYAASKHATQAFFDCLRAEMEQYEIEVTVISPGYIHTNLS 245


>gi|7657478 retinol dehydrogenase 8 (all-trans) [Homo sapiens]
          Length = 311

 Score = 79.7 bits (195), Expect = 3e-15
 Identities = 69/257 (26%), Positives = 123/257 (47%), Gaps = 24/257 (9%)

Query: 32  IFITGCDSGFG-NLAARTFD--KKGFHVIAACLTESGSTALKAETSERLRTVL----LDV 84
           + I+GC SG G  LA +     KK + V+A          L+A   E L   L    LDV
Sbjct: 8   VLISGCSSGIGLELAVQLAHDPKKRYQVVATMRDLGKKETLEAAAGEALGQTLTVAQLDV 67

Query: 85  TDPENVKRTAQWVKNQVGEKGLWGLINNAGVPGVLAPTDWLTLEDYREPIEVNLFGLISV 144
              E+V +    ++ +V       L+NNAG+ G++ P + L+L   +   + N FG + +
Sbjct: 68  CSDESVAQCLSCIQGEVDV-----LVNNAGM-GLVGPLEGLSLAAMQNVFDTNFFGAVRL 121

Query: 145 TLNMLPLVKKA-QGRVINVSSVGGRLAIVGGG-YTPSKYAVEGFNDSLRRDMKAFGVHVS 202
              +LP +K+  QG ++ +SSV G   ++    Y  SK+A+EGF +SL   +  F + +S
Sbjct: 122 VKAVLPGMKRRRQGHIVVISSVMGLQGVIFNDVYAASKFALEGFFESLAIQLLQFNIFIS 181

Query: 203 CIEPGLFKTNLADPVKVIEKKLAIWEQLSPDIKQQYGEGYIEKSLDKLKGNKSYVNMDLS 262
            +EPG   T     + + +  +A +    P+    + + Y+  S       K + ++  +
Sbjct: 182 LVEPGPVVTEFEGKL-LAQVSMAEFPGTDPETLHYFRDLYLPAS------RKLFCSVGQN 234

Query: 263 P--VVECMDHALTSLFP 277
           P  VV+ + + ++S  P
Sbjct: 235 PQDVVQAIVNVISSTRP 251


>gi|7706318 dehydrogenase/reductase (SDR family) member 7 [Homo
           sapiens]
          Length = 339

 Score = 77.4 bits (189), Expect = 2e-14
 Identities = 58/212 (27%), Positives = 110/212 (51%), Gaps = 14/212 (6%)

Query: 15  LWTR-KGKLKIEDITDKYIFITGCDSGFGNLAARTFDKKGFHVIAACLTESGSTALKAET 73
           LW   +G+    ++TD  +++TG  SG G   A    K G  ++ +         +K   
Sbjct: 35  LWAEWQGRRPEWELTDMVVWVTGASSGIGEELAYQLSKLGVSLVLSARRVHELERVKRRC 94

Query: 74  SER-------LRTVLLDVTDPENVKRTAQWVKNQVGEKGLWGLINNAGVPGVLAPTDWLT 126
            E        +  + LD+TD  + +   + V  + G   +  L+NN G+       D  +
Sbjct: 95  LENGNLKEKDILVLPLDLTDTGSHEAATKAVLQEFGRIDI--LVNNGGMSQRSLCMD-TS 151

Query: 127 LEDYREPIEVNLFGLISVTLNMLP-LVKKAQGRVINVSSVGGRLAI-VGGGYTPSKYAVE 184
           L+ YR+ IE+N  G +S+T  +LP ++++ QG+++ V+S+ G +++ +  GY  SK+A+ 
Sbjct: 152 LDVYRKLIELNYLGTVSLTKCVLPHMIERKQGKIVTVNSILGIISVPLSIGYCASKHALR 211

Query: 185 GFNDSLRRDMKAF-GVHVSCIEPGLFKTNLAD 215
           GF + LR ++  + G+ VS I PG  ++N+ +
Sbjct: 212 GFFNGLRTELATYPGIIVSNICPGPVQSNIVE 243


>gi|142976729 estradiol 17-beta-dehydrogenase 11 [Homo sapiens]
          Length = 300

 Score = 67.0 bits (162), Expect = 2e-11
 Identities = 60/222 (27%), Positives = 107/222 (48%), Gaps = 23/222 (10%)

Query: 5   VLGLLILCGF-----LWTRKGKLKIEDITDKYIFITGCDSGFGNLAARTFDKKGFHVIAA 59
           +L LLI+C       L+  K +   + +T + + ITG   G G L A  F K    ++  
Sbjct: 10  LLPLLIVCSLESFVKLFIPKRR---KSVTGEIVLITGAGHGIGRLTAYEFAKLKSKLVLW 66

Query: 60  CLTESG--STALKAE-TSERLRTVLLDVTDPENVKRTAQWVKNQVGEKGLWGLINNAGVP 116
            + + G   TA K +    ++ T ++D ++ E++  +A+ VK ++G+  +  L+NNA   
Sbjct: 67  DINKHGLEETAAKCKGLGAKVHTFVVDCSNREDIYSSAKKVKAEIGDVSI--LVNNA--- 121

Query: 117 GVLAPTDWLTLED--YREPIEVNLFGLISVTLNMLP-LVKKAQGRVINVSSVGGRLAI-V 172
           GV+  +D    +D    +  EVN+      T   LP + K   G ++ V+S  G +++  
Sbjct: 122 GVVYTSDLFATQDPQIEKTFEVNVLAHFWTTKAFLPAMTKNNHGHIVTVASAAGHVSVPF 181

Query: 173 GGGYTPSKYAVEGFNDSLRRDMKAF---GVHVSCIEPGLFKT 211
              Y  SK+A  GF+ +L  ++ A    GV  +C+ P    T
Sbjct: 182 LLAYCSSKFAAVGFHKTLTDELAALQITGVKTTCLCPNFVNT 223


>gi|223718074 hydroxysteroid (17-beta) dehydrogenase 1 [Homo
           sapiens]
          Length = 328

 Score = 66.6 bits (161), Expect = 3e-11
 Identities = 62/197 (31%), Positives = 95/197 (48%), Gaps = 16/197 (8%)

Query: 32  IFITGCDSGFG-NLAAR-TFDKKGFHVIAACLTESGSTALKAETSERL-------RTVLL 82
           + ITGC SG G +LA R   D      + A L +  +     E +  L        T+ L
Sbjct: 6   VLITGCSSGIGLHLAVRLASDPSQSFKVYATLRDLKTQGRLWEAARALACPPGSLETLQL 65

Query: 83  DVTDPENVKRTAQWVKNQVGEKGLWGLINNAGVPGVLAPTDWLTLEDYREPIEVNLFGLI 142
           DV D ++V       + +V E  +  L+ NAG+ G+L P + L  +     ++VN+ G +
Sbjct: 66  DVRDSKSVAAA----RERVTEGRVDVLVCNAGL-GLLGPLEALGEDAVASVLDVNVVGTV 120

Query: 143 SVTLNMLPLVKK-AQGRVINVSSVGGRLAI-VGGGYTPSKYAVEGFNDSLRRDMKAFGVH 200
            +    LP +K+   GRV+   SVGG + +     Y  SK+A+EG  +SL   +  FGVH
Sbjct: 121 RMLQAFLPDMKRRGSGRVLVTGSVGGLMGLPFNDVYCASKFALEGLCESLAVLLLPFGVH 180

Query: 201 VSCIEPGLFKTNLADPV 217
           +S IE G   T   + V
Sbjct: 181 LSLIECGPVHTAFMEKV 197


>gi|186928839 retinol dehydrogenase 12 [Homo sapiens]
          Length = 316

 Score = 64.7 bits (156), Expect = 1e-10
 Identities = 62/225 (27%), Positives = 103/225 (45%), Gaps = 27/225 (12%)

Query: 30  KYIFITGCDSGFGNLAARTFDKKGFHVIAACLT----ESGSTALKAET-SERLRTVLLDV 84
           K + ITG ++G G   AR    +G  V  AC      ES ++ ++ +T + ++    LD+
Sbjct: 40  KVVVITGANTGIGKETARELASRGARVYIACRDVLKGESAASEIRVDTKNSQVLVRKLDL 99

Query: 85  TDPENVKRTAQWVKNQVGEKGLWGLINNAGVPGVLAPTDWLTLEDYREPIEVNLFGLISV 144
           +D ++++  A+    +  EK L  LINNAGV  ++ P    T + +   + VN  G   +
Sbjct: 100 SDTKSIRAFAEGFLAE--EKQLHILINNAGV--MMCPYS-KTADGFETHLGVNHLGHFLL 154

Query: 145 TLNMLPLVK-KAQGRVINVSSVGGRLAIV-------------GGGYTPSKYAVEGFNDSL 190
           T  +L  +K  A  RV+NVSSV   +  +             G  Y  SK A   F   L
Sbjct: 155 TYLLLERLKVSAPARVVNVSSVAHHIGKIPFHDLQSEKRYSRGFAYCHSKLANVLFTREL 214

Query: 191 RRDMKAFGVHVSCIEPGLFKTNLADPVKVIEKKLAIWEQLSPDIK 235
            + ++  GV    + PG+ ++ L   V+       +W   SP +K
Sbjct: 215 AKRLQGTGVTTYAVHPGVVRSEL---VRHSSLLCLLWRLFSPFVK 256


>gi|157739938 dehydrogenase/reductase (SDR family) member 7C [Homo
           sapiens]
          Length = 311

 Score = 64.7 bits (156), Expect = 1e-10
 Identities = 63/224 (28%), Positives = 110/224 (49%), Gaps = 22/224 (9%)

Query: 1   MLFWVLGLLIL---CGFLWTRKGKLKIEDITDKYIFITGCDSGFGNLAARTFDKKGFHVI 57
           +L  + GLL +      LW++        + +K + IT   SG G   AR F   G  ++
Sbjct: 12  LLLGISGLLFIYQEVSRLWSKSA------VQNKVVVITDAISGLGKECARVFHTGGARLV 65

Query: 58  AACLT----ESGSTAL--KAETSERL--RTVLLDVTDPENVKRTAQWVKNQVGEKGLWGL 109
                    E+   AL   A+ S+    + VLLD++D   V   A+ V +  G   +  L
Sbjct: 66  LCGKNWERLENLYDALISVADPSKTFTPKLVLLDLSDISCVPDVAKEVLDCYGCVDI--L 123

Query: 110 INNAGVPGVLAPTDWLTLEDYREPIEVNLFGLISVTLNMLP-LVKKAQGRVINVSSVGGR 168
           INNA V  V  P   ++LE  ++ ++ N FG I++T  +LP ++ +  G+++ V+++ G+
Sbjct: 124 INNASVK-VKGPAHKISLELDKKIMDANYFGPITLTKALLPNMISRRTGQIVLVNNIQGK 182

Query: 169 LAI-VGGGYTPSKYAVEGFNDSLRRDMKAFGVHVSCIEPGLFKT 211
             I     Y  SK+A  GF D LR +++ + V +S + P   ++
Sbjct: 183 FGIPFRTTYAASKHAALGFFDCLRAEVEEYDVVISTVSPTFIRS 226


>gi|109715829 short-chain dehydrogenase/reductase [Homo sapiens]
          Length = 260

 Score = 63.5 bits (153), Expect = 2e-10
 Identities = 58/220 (26%), Positives = 98/220 (44%), Gaps = 24/220 (10%)

Query: 29  DKYIFITGCDSGFGNLAARTFDKKGFHVIAACLTESGSTALKAETSE-----RLRTVLLD 83
           D+   +TG   G G   AR   ++G  V+    T      L AE         L     D
Sbjct: 11  DRLALVTGASGGIGAAVARALVQQGLKVVGCARTVGNIEELAAECKSAGYPGTLIPYRCD 70

Query: 84  VTDPENVKRTAQWVKNQVGEKGLWGLINNAGVPGVLAPTDWL---TLEDYREPIEVNLFG 140
           +++ E++      +++Q    G+   INNAG    LA  D L   +   +++   VN+  
Sbjct: 71  LSNEEDILSMFSAIRSQ--HSGVDICINNAG----LARPDTLLSGSTSGWKDMFNVNVLA 124

Query: 141 LISVTLNMLPLVKKA---QGRVINVSSVGGRLAI---VGGGYTPSKYAVEGFNDSLRRDM 194
           L   T      +K+     G +IN++S+ G   +   V   Y+ +KYAV    + LR+++
Sbjct: 125 LSICTREAYQSMKERNVDDGHIININSMSGHRVLPLSVTHFYSATKYAVTALTEGLRQEL 184

Query: 195 KAFGVHV--SCIEPGLFKTNLADPV--KVIEKKLAIWEQL 230
           +    H+  +CI PG+ +T  A  +  K  EK  A +EQ+
Sbjct: 185 REAQTHIRATCISPGVVETQFAFKLHDKDPEKAAATYEQM 224


>gi|210032110 hydroxysteroid (17-beta) dehydrogenase 13 isoform A
           [Homo sapiens]
          Length = 300

 Score = 61.6 bits (148), Expect = 9e-10
 Identities = 51/197 (25%), Positives = 93/197 (47%), Gaps = 15/197 (7%)

Query: 25  EDITDKYIFITGCDSGFGNLAARTFDKKGFHVIAACLTESGSTALKAETSE---RLRTVL 81
           + +  + + ITG   G G      F K+   ++   + + G     AE  +        +
Sbjct: 32  KSVAGEIVLITGAGHGIGRQTTYEFAKRQSILVLWDINKRGVEETAAECRKLGVTAHAYV 91

Query: 82  LDVTDPENVKRTAQWVKNQVGEKGLWGLINNAGVPGVLAPTDWLTLEDYR--EPIEVNLF 139
           +D ++ E + R+   VK +VG+  +  ++NNAG    + P D L+ +D    +  EVN+ 
Sbjct: 92  VDCSNREEIYRSLNQVKKEVGDVTI--VVNNAGT---VYPADLLSTKDEEITKTFEVNIL 146

Query: 140 GLISVTLNMLP-LVKKAQGRVINVSSVGGRLAIVGG-GYTPSKYAVEGFNDSLRRDMKAF 197
           G   +T  +LP ++++  G ++ V+SV G   I     Y  SK+A  GF+  L  +++A 
Sbjct: 147 GHFWITKALLPSMMERNHGHIVTVASVCGHEGIPYLIPYCSSKFAAVGFHRGLTSELQAL 206

Query: 198 ---GVHVSCIEPGLFKT 211
              G+  SC+ P    T
Sbjct: 207 GKTGIKTSCLCPVFVNT 223


>gi|4758504 hydroxysteroid (17-beta) dehydrogenase 10 isoform 1
           [Homo sapiens]
          Length = 261

 Score = 59.3 bits (142), Expect = 4e-09
 Identities = 58/198 (29%), Positives = 83/198 (41%), Gaps = 25/198 (12%)

Query: 34  ITGCDSGFGNLAARTFDKKGFHVIAACLTESGSTALKAETSERLRTVLLDVTDPENVKRT 93
           ITG  SG G   A     +G   +   L  SG  A   +          DVT  ++V+  
Sbjct: 15  ITGGASGLGLATAERLVGQGASAVLLDLPNSGGEAQAKKLGNNCVFAPADVTSEKDVQTA 74

Query: 94  AQWVKNQVGEKGLWGLINNAGVPGVLAPTDWL------TLEDYREPIEVNLFGLISVTLN 147
               K + G   +   +N AG+  V + T  L      TLED++  ++VNL G    T N
Sbjct: 75  LALAKGKFGRVDV--AVNCAGI-AVASKTYNLKKGQTHTLEDFQRVLDVNLMG----TFN 127

Query: 148 MLPLVKKAQGR-----------VINVSSVGGRLAIVG-GGYTPSKYAVEGFNDSLRRDMK 195
           ++ LV    G+           +IN +SV      VG   Y+ SK  + G    + RD+ 
Sbjct: 128 VIRLVAGEMGQNEPDQGGQRGVIINTASVAAFEGQVGQAAYSASKGGIVGMTLPIARDLA 187

Query: 196 AFGVHVSCIEPGLFKTNL 213
             G+ V  I PGLF T L
Sbjct: 188 PIGIRVMTIAPGLFGTPL 205


>gi|32455239 11-beta-hydroxysteroid dehydrogenase 1 [Homo sapiens]
          Length = 292

 Score = 59.3 bits (142), Expect = 4e-09
 Identities = 52/206 (25%), Positives = 98/206 (47%), Gaps = 15/206 (7%)

Query: 5   VLGLLILCGFLWTRKGKLKIEDITDKYIFITGCDSGFGNLAARTFDKKGFHVIAACLTE- 63
           +LGL  +  + ++   + + E +  K + +TG   G G   A    K G HV+    ++ 
Sbjct: 11  ILGLF-MAYYYYSANEEFRPEMLQGKKVIVTGASKGIGREMAYHLAKMGAHVVVTARSKE 69

Query: 64  ------SGSTALKAETSERLRTVLLDVTDPENVKRTAQWVKNQVGEKGLWGLINNAGVPG 117
                 S    L A ++  +   + D+T  E     AQ  K   G   L  ++N+     
Sbjct: 70  TLQKVVSHCLELGAASAHYIAGTMEDMTFAEQF--VAQAGKLMGGLDML--ILNHITNTS 125

Query: 118 VLAPTDWLTLEDYREPIEVNLFGLISVTLNMLPLVKKAQGRVINVSSVGGRLAI-VGGGY 176
           +    D   +   R+ +EVN    + +T+  LP++K++ G ++ VSS+ G++A  +   Y
Sbjct: 126 LNLFHD--DIHHVRKSMEVNFLSYVVLTVAALPMLKQSNGSIVVVSSLAGKVAYPMVAAY 183

Query: 177 TPSKYAVEGFNDSLRRDMKAFGVHVS 202
           + SK+A++GF  S+R++     V+VS
Sbjct: 184 SASKFALDGFFSSIRKEYSVSRVNVS 209


>gi|5031765 11-beta-hydroxysteroid dehydrogenase 1 [Homo sapiens]
          Length = 292

 Score = 59.3 bits (142), Expect = 4e-09
 Identities = 52/206 (25%), Positives = 98/206 (47%), Gaps = 15/206 (7%)

Query: 5   VLGLLILCGFLWTRKGKLKIEDITDKYIFITGCDSGFGNLAARTFDKKGFHVIAACLTE- 63
           +LGL  +  + ++   + + E +  K + +TG   G G   A    K G HV+    ++ 
Sbjct: 11  ILGLF-MAYYYYSANEEFRPEMLQGKKVIVTGASKGIGREMAYHLAKMGAHVVVTARSKE 69

Query: 64  ------SGSTALKAETSERLRTVLLDVTDPENVKRTAQWVKNQVGEKGLWGLINNAGVPG 117
                 S    L A ++  +   + D+T  E     AQ  K   G   L  ++N+     
Sbjct: 70  TLQKVVSHCLELGAASAHYIAGTMEDMTFAEQF--VAQAGKLMGGLDML--ILNHITNTS 125

Query: 118 VLAPTDWLTLEDYREPIEVNLFGLISVTLNMLPLVKKAQGRVINVSSVGGRLAI-VGGGY 176
           +    D   +   R+ +EVN    + +T+  LP++K++ G ++ VSS+ G++A  +   Y
Sbjct: 126 LNLFHD--DIHHVRKSMEVNFLSYVVLTVAALPMLKQSNGSIVVVSSLAGKVAYPMVAAY 183

Query: 177 TPSKYAVEGFNDSLRRDMKAFGVHVS 202
           + SK+A++GF  S+R++     V+VS
Sbjct: 184 SASKFALDGFFSSIRKEYSVSRVNVS 209


>gi|166795268 retinol dehydrogenase 11 [Homo sapiens]
          Length = 318

 Score = 59.3 bits (142), Expect = 4e-09
 Identities = 60/203 (29%), Positives = 95/203 (46%), Gaps = 24/203 (11%)

Query: 30  KYIFITGCDSGFGNLAARTFDKKGFHVIAACL-TESGS-TALKAETSERLRTVL---LDV 84
           K + +TG ++G G   A+   ++G  V  AC   E G   A + +T+   + VL   LD+
Sbjct: 42  KVVVVTGANTGIGKETAKELAQRGARVYLACRDVEKGELVAKEIQTTTGNQQVLVRKLDL 101

Query: 85  TDPENVKRTAQWVKNQVGEKGLWGLINNAGVPGVLAPTDWLTLEDYREPIEVNLFGLISV 144
           +D ++++  A+    +  EK L  LINNAGV  ++ P    T + +   I VN  G   +
Sbjct: 102 SDTKSIRAFAKGFLAE--EKHLHVLINNAGV--MMCPYS-KTADGFEMHIGVNHLGHFLL 156

Query: 145 TLNMLPLVKK-AQGRVINVSSVGGRLAIV-------------GGGYTPSKYAVEGFNDSL 190
           T  +L  +K+ A  R++NVSS+   L  +             G  Y  SK A   F   L
Sbjct: 157 THLLLEKLKESAPSRIVNVSSLAHHLGRIHFHNLQGEKFYNAGLAYCHSKLANILFTQEL 216

Query: 191 RRDMKAFGVHVSCIEPGLFKTNL 213
            R +K  GV    + PG  ++ L
Sbjct: 217 ARRLKGSGVTTYSVHPGTVQSEL 239


>gi|225579078 retinol dehydrogenase 13 isoform 1 [Homo sapiens]
          Length = 331

 Score = 58.9 bits (141), Expect = 6e-09
 Identities = 55/207 (26%), Positives = 94/207 (45%), Gaps = 25/207 (12%)

Query: 27  ITDKYIFITGCDSGFGNLAARTFDKKGFHVIAAC----LTESGSTALKAET-SERLRTVL 81
           I  K + +TG ++G G   A    ++G ++I AC      E+ +  ++ ET +  +    
Sbjct: 36  IPGKTVIVTGANTGIGKQTALELARRGGNIILACRDMEKCEAAAKDIRGETLNHHVNARH 95

Query: 82  LDVTDPENVKRTAQWVKNQVGEKGLWGLINNAGVPGVLAPTDWLTLEDYREPIEVNLFGL 141
           LD+   ++++  A  +  +  E+ +  LINNA   GV+    W T + +     VN  G 
Sbjct: 96  LDLASLKSIREFAAKIIEE--EERVDILINNA---GVMRCPHWTTEDGFEMQFGVNHLGH 150

Query: 142 ISVTLNMLPLVK-KAQGRVINVSS---VGGRLAI-----------VGGGYTPSKYAVEGF 186
             +T  +L  +K  A  R+IN+SS   V G +                 Y  SK A+  F
Sbjct: 151 FLLTNLLLDKLKASAPSRIINLSSLAHVAGHIDFDDLNWQTRKYNTKAAYCQSKLAIVLF 210

Query: 187 NDSLRRDMKAFGVHVSCIEPGLFKTNL 213
              L R ++  GV V+ + PG+ +T L
Sbjct: 211 TKELSRRLQGSGVTVNALHPGVARTEL 237


>gi|40254992 carbonic reductase 4 [Homo sapiens]
          Length = 237

 Score = 57.0 bits (136), Expect = 2e-08
 Identities = 45/194 (23%), Positives = 85/194 (43%), Gaps = 9/194 (4%)

Query: 29  DKYIFITGCDSGFGNLAARTFDKKGFHVIAACLTESGSTALKAETSERLRTVLLDVTDPE 88
           DK   + G   G G   A+   +KG+ +        G+ A   +          DV    
Sbjct: 2   DKVCAVFGGSRGIGRAVAQLMARKGYRLAVIARNLEGAKAAAGDLGGDHLAFSCDVAKEH 61

Query: 89  NVKRTAQWVKNQVGEKGLWGLINNAGV--PGVLAPTDWLTLEDYREPIEVNLFG-LISVT 145
           +V+ T + ++  +G      L+N AG+   G+L  T     ED    +  NL G +++  
Sbjct: 62  DVQNTFEELEKHLGRVNF--LVNAAGINRDGLLVRTK---TEDMVSQLHTNLLGSMLTCK 116

Query: 146 LNMLPLVKKAQGRVINVSSVGGRLAIVGGG-YTPSKYAVEGFNDSLRRDMKAFGVHVSCI 204
             M  ++++  G ++NV S+ G     G   Y+ SK  + GF+ +L +++    + V+ +
Sbjct: 117 AAMRTMIQQQGGSIVNVGSIVGLKGNSGQSVYSASKGGLVGFSRALAKEVARKKIRVNVV 176

Query: 205 EPGLFKTNLADPVK 218
            PG   T++   +K
Sbjct: 177 APGFVHTDMTKDLK 190


>gi|33667109 dehydrogenase/reductase member 2 isoform 1 [Homo
           sapiens]
          Length = 300

 Score = 55.5 bits (132), Expect = 6e-08
 Identities = 46/195 (23%), Positives = 88/195 (45%), Gaps = 2/195 (1%)

Query: 27  ITDKYIFITGCDSGFGNLAARTFDKKGFHVIAACLTESGSTALKAETSERLRTVLLDVTD 86
           + ++   +TG  SG G   AR   + G HV+ +   +       A+      +V   V  
Sbjct: 34  LANRVAVVTGSTSGIGFAIARRLARDGAHVVISSRKQQNVDRAMAKLQGEGLSVAGIVCH 93

Query: 87  PENVKRTAQWVKNQVGE-KGLWGLINNAGVPGVLAPTDWLTLEDYREPIEVNLFGLISVT 145
               +   Q V   +    G+  L+ +AGV  ++  T   + + + + + VN+     + 
Sbjct: 94  VGKAEDREQLVAKALEHCGGVDFLVCSAGVNPLVGSTLGTSEQIWDKILSVNVKSPALLL 153

Query: 146 LNMLPLVKKAQGRVINVSSVGGRLAIVG-GGYTPSKYAVEGFNDSLRRDMKAFGVHVSCI 204
             +LP ++  +G VI VSS+     +V  G Y  SK A+ G   +L  ++    + V+C+
Sbjct: 154 SQLLPYMENRRGAVILVSSIAAYNPVVALGVYNVSKTALLGLTRTLALELAPKDIRVNCV 213

Query: 205 EPGLFKTNLADPVKV 219
            PG+ KT+ +  V++
Sbjct: 214 VPGIIKTDFSKVVRI 228


  Database: hs.faa
    Posted date:  Aug 4, 2009  4:42 PM
  Number of letters in database: 18,247,518
  Number of sequences in database:  37,866
  
Lambda     K      H
   0.320    0.138    0.417 

Gapped
Lambda     K      H
   0.267   0.0410    0.140 


Matrix: BLOSUM62
Gap Penalties: Existence: 11, Extension: 1
Number of Hits to DB: 11,990,694
Number of Sequences: 37866
Number of extensions: 511174
Number of successful extensions: 1538
Number of sequences better than 10.0: 30
Number of HSP's better than 10.0 without gapping: 27
Number of HSP's successfully gapped in prelim test: 51
Number of HSP's that attempted gapping in prelim test: 1432
Number of HSP's gapped (non-prelim): 89
length of query: 319
length of database: 18,247,518
effective HSP length: 102
effective length of query: 217
effective length of database: 14,385,186
effective search space: 3121585362
effective search space used: 3121585362
T: 11
A: 40
X1: 16 ( 7.4 bits)
X2: 38 (14.6 bits)
X3: 64 (24.7 bits)
S1: 41 (21.8 bits)
S2: 62 (28.5 bits)

Search results were obtained with NCBI BLAST and RefSeq entries.


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Guide to the Human Genome
Copyright © 2010 by Stewart Scherer. All rights reserved.

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