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Search of human proteins with 22749429
BLASTP 2.2.11 [Jun-05-2005]
Reference: Altschul, Stephen F., Thomas L. Madden, Alejandro A. Schaffer,
Jinghui Zhang, Zheng Zhang, Webb Miller, and David J. Lipman (1997),
"Gapped BLAST and PSI-BLAST: a new generation of protein database search
programs", Nucleic Acids Res. 25:3389-3402.
Query= gi|22749429 coiled-coil domain containing 89 [Homo sapiens]
(374 letters)
Database: hs.faa
37,866 sequences; 18,247,518 total letters
Searching..................................................done
Score E
Sequences producing significant alignments: (bits) Value
gi|22749429 coiled-coil domain containing 89 [Homo sapiens] 716 0.0
gi|148746195 trichohyalin [Homo sapiens] 82 1e-15
gi|222446603 golgi autoantigen, golgin subfamily a-like [Homo sa... 77 3e-14
gi|205277396 dynactin 1 isoform 4 [Homo sapiens] 75 1e-13
gi|205277392 dynactin 1 isoform 3 [Homo sapiens] 75 1e-13
gi|13259508 dynactin 1 isoform 2 [Homo sapiens] 75 1e-13
gi|13259510 dynactin 1 isoform 1 [Homo sapiens] 75 1e-13
gi|239745089 PREDICTED: golgi autoantigen, golgin subfamily a-li... 74 2e-13
gi|239745079 PREDICTED: Putative golgin subfamily A member 6-lik... 74 2e-13
gi|154350244 hypothetical protein LOC79632 isoform 2 [Homo sapiens] 73 5e-13
gi|154350226 hypothetical protein LOC79632 isoform 1 [Homo sapiens] 73 5e-13
gi|157738667 FYVE and coiled-coil domain containing 1 [Homo sapi... 72 6e-13
gi|12667788 myosin, heavy polypeptide 9, non-muscle [Homo sapiens] 72 8e-13
gi|13124879 smooth muscle myosin heavy chain 11 isoform SM1A [Ho... 72 8e-13
gi|92091586 smooth muscle myosin heavy chain 11 isoform SM1B [Ho... 72 8e-13
gi|92091583 smooth muscle myosin heavy chain 11 isoform SM2B [Ho... 72 8e-13
gi|13124875 smooth muscle myosin heavy chain 11 isoform SM2A [Ho... 72 8e-13
gi|239756241 PREDICTED: golgi autoantigen, golgin subfamily a-li... 72 1e-12
gi|22538393 A-kinase anchor protein 9 isoform 3 [Homo sapiens] 72 1e-12
gi|59806361 hypothetical protein LOC387104 [Homo sapiens] 71 1e-12
gi|32698688 citron [Homo sapiens] 71 1e-12
gi|22538387 A-kinase anchor protein 9 isoform 2 [Homo sapiens] 71 2e-12
gi|239745095 PREDICTED: hypothetical protein LOC645202 [Homo sap... 70 2e-12
gi|114155142 nuclear pore complex-associated protein TPR [Homo s... 70 2e-12
gi|148596984 golgi autoantigen, golgin subfamily b, macrogolgin ... 70 4e-12
gi|31563507 GRIP and coiled-coil domain-containing 2 [Homo sapiens] 69 9e-12
gi|222418637 golgi autoantigen, golgin subfamily a-like [Homo sa... 68 1e-11
gi|41406064 myosin, heavy polypeptide 10, non-muscle [Homo sapiens] 68 1e-11
gi|71061468 centromere protein E [Homo sapiens] 68 1e-11
gi|41322923 plectin 1 isoform 11 [Homo sapiens] 68 1e-11
>gi|22749429 coiled-coil domain containing 89 [Homo sapiens]
Length = 374
Score = 716 bits (1847), Expect = 0.0
Identities = 374/374 (100%), Positives = 374/374 (100%)
Query: 1 MRAPMLQKQQAPRMDTPPPEERLEKQNEKLNNQEEETEFKELDGLREALANLRGLSEEER 60
MRAPMLQKQQAPRMDTPPPEERLEKQNEKLNNQEEETEFKELDGLREALANLRGLSEEER
Sbjct: 1 MRAPMLQKQQAPRMDTPPPEERLEKQNEKLNNQEEETEFKELDGLREALANLRGLSEEER 60
Query: 61 SEKAMLRSRIEEQSQLICILKRRSDEALERCQILELLNAELEEKMMQEAEKLKAQGEYSR 120
SEKAMLRSRIEEQSQLICILKRRSDEALERCQILELLNAELEEKMMQEAEKLKAQGEYSR
Sbjct: 61 SEKAMLRSRIEEQSQLICILKRRSDEALERCQILELLNAELEEKMMQEAEKLKAQGEYSR 120
Query: 121 KLEERFMTLAANHELMLRFKDEYKSENIKLREENEKLRLENSSLFSQALKDEEAKVLQLT 180
KLEERFMTLAANHELMLRFKDEYKSENIKLREENEKLRLENSSLFSQALKDEEAKVLQLT
Sbjct: 121 KLEERFMTLAANHELMLRFKDEYKSENIKLREENEKLRLENSSLFSQALKDEEAKVLQLT 180
Query: 181 VRCEALTGELETLKERCAQDACQAQAREKELLELQSQQACTHTKETEQLRSQLQTLKQQH 240
VRCEALTGELETLKERCAQDACQAQAREKELLELQSQQACTHTKETEQLRSQLQTLKQQH
Sbjct: 181 VRCEALTGELETLKERCAQDACQAQAREKELLELQSQQACTHTKETEQLRSQLQTLKQQH 240
Query: 241 QQAVEQIAKAEETHSSLSQELQARLQTVTREKEELLQLSIERGKVLQNKQAEICQLEEKL 300
QQAVEQIAKAEETHSSLSQELQARLQTVTREKEELLQLSIERGKVLQNKQAEICQLEEKL
Sbjct: 241 QQAVEQIAKAEETHSSLSQELQARLQTVTREKEELLQLSIERGKVLQNKQAEICQLEEKL 300
Query: 301 EIANEDRKHALERFEQEAVAVDSNLRVRELQRKVDGIQKAYDELRLQSEAFKKHSLDLLS 360
EIANEDRKHALERFEQEAVAVDSNLRVRELQRKVDGIQKAYDELRLQSEAFKKHSLDLLS
Sbjct: 301 EIANEDRKHALERFEQEAVAVDSNLRVRELQRKVDGIQKAYDELRLQSEAFKKHSLDLLS 360
Query: 361 KERELNGKLRHLSP 374
KERELNGKLRHLSP
Sbjct: 361 KERELNGKLRHLSP 374
>gi|148746195 trichohyalin [Homo sapiens]
Length = 1943
Score = 81.6 bits (200), Expect = 1e-15
Identities = 93/395 (23%), Positives = 174/395 (44%), Gaps = 47/395 (11%)
Query: 7 QKQQAPRMDTPPPEERLEKQNEKLNNQEEETEFKELDGLREALAN----LRGLSEEERSE 62
++QQ R E+ E++ E+ +E++ E +E RE LR EEER E
Sbjct: 302 REQQLRRKQEEERREQQEERREQQERREQQEERREQQLRREQEERREQQLRREQEEERRE 361
Query: 63 KAMLRSRIEE--QSQLICILKRRSDEALERCQILELLNAELEEKMMQEAEKLKAQGEYSR 120
+ + R + EE + QL + R ++ L R Q L E+ ++ ++L+ + + R
Sbjct: 362 QQLRREQEEERREQQLRREQQLRREQQLRREQQLRREQQLRREQQLRREQQLRREQQLRR 421
Query: 121 KLEERFMTLAANHELM-------LRFKDEYKSENIKLREENEKLRLENSSLFSQALKDEE 173
+ + R HE R K E + L+ E E R E Q +D+E
Sbjct: 422 EQQLRREQEEERHEQKHEQERREQRLKREQEERRDWLKREEETERHEQERRKQQLKRDQE 481
Query: 174 AKVLQLTVRCEALTGELETLKERCAQDACQAQAREKELLELQSQQACTHTKETEQLRSQL 233
+ + ++ LE + R Q+ + Q R ++ E + +Q +E E+L+ +L
Sbjct: 482 EERRERWLK-------LEEEERREQQERREQQLRREQ--EERREQRLKRQEEEERLQQRL 532
Query: 234 ---QTLKQQHQQAVEQIAKAEETH--------------------SSLSQELQARLQTVTR 270
Q L+++ ++ EQ+ K EE L +E + R Q + R
Sbjct: 533 RSEQQLRREQEERREQLLKREEEKRLEQERREQRLKREQEERRDQLLKREEERRQQRLKR 592
Query: 271 EKEELLQLSIERGKVLQNKQAEICQLEEKLEIANEDRKHALERFEQEAVAVDSNLRVREL 330
E+EE L+ ++R +V + +Q E + K E E+R+ L + E++ LR +
Sbjct: 593 EQEERLEQRLKREEVERLEQEERREQRLKREEPEEERRQQLLKSEEQEERRQQQLRREQQ 652
Query: 331 QRKVDGIQKAYDELRLQSEAFKKHSLDLLSKEREL 365
+R+ +++ +E RL+ ++H + +E+EL
Sbjct: 653 ERREQRLKREEEEERLEQRLKREHEEE--RREQEL 685
Score = 73.6 bits (179), Expect = 3e-13
Identities = 92/358 (25%), Positives = 169/358 (47%), Gaps = 33/358 (9%)
Query: 17 PPPEERLEKQNEKLNNQEEETEFKELDGLREALANLRGLSEEE--RSEKAMLRSRIEEQS 74
P +E+L K+ + L +EEE + +E + R + EE+ + E+ +LR E++
Sbjct: 893 PALQEQLRKEQQLLQEEEEELQREEREKRRRQEQERQYREEEQLQQEEEQLLREEREKRR 952
Query: 75 QLICILKRRSDEALERCQILELLNAELEEKMMQEAEKLKAQGEYSRKLEERFM------T 128
+ + R D+ L++ + +LL E E++ QE EK + E ++ EE+ +
Sbjct: 953 RQERERQYRKDKKLQQKEE-QLLGEEPEKRRRQEREKKYREEEELQQEEEQLLREEREKR 1011
Query: 129 LAANHELMLRFKDEYKSENIK-LREENEKLRLENSSLFSQALKDEEAKVLQLTVRCEALT 187
E R KDE + E + LREE EK RL+ + ++EE +L E L
Sbjct: 1012 RRQEWERQYRKKDELQQEEEQLLREEREKRRLQER---ERQYREEE----ELQQEEEQLL 1064
Query: 188 GELETLKERCAQDACQAQAREKELLELQSQQACTHTKETEQLRSQLQTLKQQH--QQAVE 245
GE + R + Q R++E L+ + +Q E + + + + +++ QQ E
Sbjct: 1065 GEERETRRR---QELERQYRKEEELQQEEEQLLREEPEKRRRQERERQCREEEELQQEEE 1121
Query: 246 QIAKAEETHSSLSQELQARL---QTVTREKEELLQLSIERGK----VLQNKQAEICQLEE 298
Q+ + EE QEL+ + + V +E+E+LL+ E+ + Q ++ E Q EE
Sbjct: 1122 QLLR-EEREKRRRQELERQYREEEEVQQEEEQLLREEPEKRRRQELERQYREEEELQQEE 1180
Query: 299 KLEIANEDRKHALERFEQEAVAVDSNLRVRELQRKVDGIQKAYDELRLQSEAFKKHSL 356
+ + E K ER E++ + R + QR D Q++ +L+ Q E K++++
Sbjct: 1181 EQLLREEQEKRRQER-ERQYREEEELQRQKRKQRYRDEDQRS--DLKWQWEPEKENAV 1235
Score = 68.9 bits (167), Expect = 7e-12
Identities = 85/342 (24%), Positives = 158/342 (46%), Gaps = 28/342 (8%)
Query: 7 QKQQAPRMDTPPPEERLEKQNEKLNNQEEETEFKELDGLREALANLRGLSEEERSEKAML 66
QK+Q + EE+ EKQ E+L ++ + +EL R+ EE R+E+ L
Sbjct: 139 QKRQEQERELAEGEEQSEKQ-ERLEQRDRQRRDEELWRQRQEWQE----REERRAEEEQL 193
Query: 67 RSRIEEQSQLICILKRRSDEALERCQILELLNAELEEKMMQEAEKLKA--QGEYSRKLEE 124
+S +++ + +E L R ++LEL EEK Q E+ Q E ++ +
Sbjct: 194 QSCKGHETE-----EFPDEEQLRRRELLELRRKGREEKQQQRRERQDRVFQEEEEKEWRK 248
Query: 125 RFMTLAANHELMLRFKDEYKSENIKLREENEKLR-LENSSLFSQALKDEEAKVLQLTVRC 183
R L E + ++E +L+EE E+LR LE L + + EE + Q R
Sbjct: 249 RETVLRKEEE---KLQEEEPQRQRELQEEEEQLRKLERQELRRE--RQEEEQQQQRLRRE 303
Query: 184 EALTGELETLKERCAQDACQAQAREKELLELQSQQACTHTKETEQLRSQLQTLKQQHQQA 243
+ L + E + ++ + Q R ++ E + QQ +E E+ R Q Q ++Q ++
Sbjct: 304 QQLRRKQEEERREQQEERREQQERREQQEERREQQL---RREQEERREQ-QLRREQEEER 359
Query: 244 VEQIAKAEETHSSLSQELQARLQTVTREKEELLQLSIERGKVLQNKQAEICQLEEKLEIA 303
EQ + E+ Q+L+ R Q + RE++ + + R + L+ +Q + E++L
Sbjct: 360 REQQLRREQEEERREQQLR-REQQLRREQQLRREQQLRREQQLRREQQ--LRREQQLRRE 416
Query: 304 NEDRKHALERFEQEAVAVDSNLRVRELQRKVDGIQKAYDELR 345
+ R+ R EQE + + + E +R+ +++ +E R
Sbjct: 417 QQLRREQQLRREQEE---ERHEQKHEQERREQRLKREQEERR 455
Score = 62.4 bits (150), Expect = 6e-10
Identities = 74/344 (21%), Positives = 152/344 (44%), Gaps = 32/344 (9%)
Query: 5 MLQKQQAPRMDTPPPEERLEKQNEKLNNQEEETEFKELDGLREALANLRGLSEEERSEKA 64
+LQ+++ ++ + + ++ ++L QE + +F+E + LR + L EE++ +
Sbjct: 1469 LLQEREEQQLHRQERDRKFLEEEQQLRRQERDRKFREQE-LRSQEPERKFLEEEQQLHRQ 1527
Query: 65 MLRSR-IEEQSQLICILKRRSDEALERCQILELLNAELEEKMMQEAEKLKAQGEYSRKLE 123
+ + ++E+ QL RR + +R Q + E E+ + E+ ++ E RK
Sbjct: 1528 QRQRKFLQEEQQL-----RRQERGQQRRQDRDRKFREEEQLRQEREEQQLSRQERDRKFR 1582
Query: 124 ERFMTLAANHELMLRFKDEYKSENIKLREENEKLRLENSSLF---SQALKDEEAKVLQLT 180
+ + +DE + ++ +E ++LR E F Q L++ E + L
Sbjct: 1583 LEEQKVRRQEQERKFMEDE---QQLRRQEGQQQLRQERDRKFREDEQLLQEREEQQLHRQ 1639
Query: 181 VRCEALTGELETLK-----ERCAQDACQAQAREKELLELQSQQACTHTKETEQLRSQLQT 235
R E L+ ++ D + E++LL+ +Q + + R + Q
Sbjct: 1640 ERDRKFLEEEPQLRRQEREQQLRHDRDRKFREEEQLLQEGEEQQLRRQERDRKFREEEQQ 1699
Query: 236 LKQQHQQ----AVEQIAKAEETHSSLSQELQARLQTVTREKEELLQLSIERGKVLQNKQA 291
L++Q ++ EQ + +E +E Q R +T E+E+L + R K+L+ +Q
Sbjct: 1700 LRRQERERKFLQEEQQLRRQELERKFREEEQLRQET---EQEQLRRQERYR-KILEEEQL 1755
Query: 292 EICQLEEKLEIANEDRKH------ALERFEQEAVAVDSNLRVRE 329
+ E++L DRK ER EQ+ + +S+ + RE
Sbjct: 1756 RPEREEQQLRRQERDRKFREEEQLRQEREEQQLRSQESDRKFRE 1799
Score = 60.8 bits (146), Expect = 2e-09
Identities = 82/358 (22%), Positives = 159/358 (44%), Gaps = 45/358 (12%)
Query: 2 RAPMLQKQQAPRMDTPPPEERLEKQNEKLNNQ--EEETEFKELDGLREALANLRGLSEEE 59
R +L++++ R++ E+RL+++ E+ +Q + E E ++ RE +EE
Sbjct: 546 REQLLKREEEKRLEQERREQRLKREQEERRDQLLKREEERRQQRLKRE---------QEE 596
Query: 60 RSEKAMLRSRIEEQSQLICILKRRSDEALERCQILELLNAELEEKMMQEAEKLKAQGEYS 119
R E+ + R +E Q + R ++ L+R E EE+ Q+ LK++ +
Sbjct: 597 RLEQRLKREEVERLEQ-----EERREQRLKR--------EEPEEERRQQL--LKSEEQEE 641
Query: 120 RKLEERFMTLAANHELMLRFKDEYKSENIKLREENEKLRLENSSLFSQALKDEEAKVLQL 179
R+ ++ E L+ ++E + +L+ E+E+ R E Q L +EE + +
Sbjct: 642 RRQQQLRREQQERREQRLKREEEEERLEQRLKREHEEERRE------QELAEEEQEQARE 695
Query: 180 TVRCEALTGELETLKERCA-QDACQAQAREKELLELQSQQACTHTKETEQLRSQLQTLKQ 238
++ + + E A Q ++ R++E + +Q + +L+ Q +
Sbjct: 696 RIKSRIPKWQWQLESEADARQSKVYSRPRKQEGQRRRQEQEEKRRRRESELQWQEEERAH 755
Query: 239 QHQQAVEQIA------KAEETHSSLSQELQARLQTVTREKEELLQLSIERGKVLQNKQAE 292
+ QQ EQ +AEE Q L AR RE+ E + ER Q +Q
Sbjct: 756 RQQQEEEQRRDFTWQWQAEEKSERGRQRLSAR--PPLREQRERQLRAEER---QQREQRF 810
Query: 293 ICQLEEKLEIANEDRKHALE-RFEQEAVAVDSNLRVRELQRKVDGIQKAYDELRLQSE 349
+ + EEK + + R+ E +F +E + R ++LQ + DG+Q+ + R Q +
Sbjct: 811 LPEEEEKEQRRRQRREREKELQFLEEEEQLQRRERAQQLQEEEDGLQEDQERRRSQEQ 868
Score = 60.5 bits (145), Expect = 2e-09
Identities = 80/337 (23%), Positives = 147/337 (43%), Gaps = 42/337 (12%)
Query: 39 FKELDGLREALANLRGLSEEERS----EKAMLRSRIEEQSQLICILKRRSDEALERCQIL 94
FK AL GL EE+R+ ++++L+ R +E+ Q RR + R + L
Sbjct: 79 FKVAQACYYALGQATGLDEEKRARCDGKESLLQDRRQEEDQ------RRFEP---RDRQL 129
Query: 95 ELLNAELEEKMMQEAEKLKAQGEYSRKLEERF--MTLAANHELMLRFKDEYKSENIKLRE 152
E + + QE E+ A+GE + +ER E + R + E++ + E
Sbjct: 130 EEEPGQRRRQKRQEQERELAEGEEQSEKQERLEQRDRQRRDEELWRQRQEWQEREERRAE 189
Query: 153 ENEKLRLENSSLFSQALKDEEAKVLQLTVRCEALTGELETLKERCAQDACQAQAREKELL 212
E + + ++ DEE QL R EL L+ + ++ Q Q RE++
Sbjct: 190 EEQLQSCKGHE--TEEFPDEE----QLRRR------ELLELRRKGREEK-QQQRRERQDR 236
Query: 213 ELQSQQACTHTKETEQLRSQLQTLKQQHQQAVEQIAKAEETHSSLSQELQARLQTVTREK 272
Q ++ K LR + + L+++ Q ++ + EE L ++ R R++
Sbjct: 237 VFQEEEEKEWRKRETVLRKEEEKLQEEEPQRQRELQEEEEQLRKLERQELRR----ERQE 292
Query: 273 EELLQLSIERGKVLQNKQAEICQLEEKLEIANEDRKHALERFEQEAVAVDSNLRVRELQR 332
EE Q + R + L+ KQ EE+ E+R+ ER EQ+ + LR + +R
Sbjct: 293 EEQQQQRLRREQQLRRKQ------EEERREQQEERREQQERREQQEERREQQLRREQEER 346
Query: 333 KVDGIQKAYDELR----LQSEAFKKHSLDLLSKEREL 365
+ +++ +E R L+ E ++ L +E++L
Sbjct: 347 REQQLRREQEEERREQQLRREQEEERREQQLRREQQL 383
Score = 60.1 bits (144), Expect = 3e-09
Identities = 81/366 (22%), Positives = 159/366 (43%), Gaps = 46/366 (12%)
Query: 7 QKQQAPRMDTPPPEERLEKQNEKLNNQEEETEFK-ELDGLREALANLRGLSEEE--RSEK 63
++Q R + R E++ ++L+ QE + +F+ E +R + + +E+ R ++
Sbjct: 1549 RRQDRDRKFREEEQLRQEREEQQLSRQERDRKFRLEEQKVRRQEQERKFMEDEQQLRRQE 1608
Query: 64 AMLRSRIEEQSQLICILKRRSDEALERCQILELLNAELEEKMMQEAEKLKAQG------- 116
+ R E + R ++ L+ + +L E + K ++E +L+ Q
Sbjct: 1609 GQQQLRQERDRKF-----REDEQLLQEREEQQLHRQERDRKFLEEEPQLRRQEREQQLRH 1663
Query: 117 EYSRKLEERFMTLAANHELMLRFKDEYKSENIKLREENEKLRL-ENSSLFSQALKDEEAK 175
+ RK E L E LR ++ + K REE ++LR E F Q + +
Sbjct: 1664 DRDRKFREEEQLLQEGEEQQLRRQERDR----KFREEEQQLRRQERERKFLQEEQQLRRQ 1719
Query: 176 VLQLTVRCEALTGELETLKERCAQDACQAQAREKELLELQSQQACTHTKETEQLRSQL-- 233
L+ R E E L++ Q+ + Q R +++LE ++ +E +QLR Q
Sbjct: 1720 ELERKFR------EEEQLRQETEQEQLRRQERYRKILE---EEQLRPEREEQQLRRQERD 1770
Query: 234 ------QTLKQQHQQAVEQIAKAEETHSSLSQELQARLQTVTREKEELLQLSIERGKVLQ 287
+ L+Q+ + EQ +++E+ +E Q R +E+EE QL ++
Sbjct: 1771 RKFREEEQLRQERE---EQQLRSQESDRKFREEEQLR-----QEREE-QQLRPQQRDGKY 1821
Query: 288 NKQAEICQLEEKLEIANEDRKHALERFEQEAVAVDSNLRVRELQRKVDGIQKAYDELRLQ 347
+ E QLEE+ + ++R EQ A S +EL ++ + ++ E +L+
Sbjct: 1822 RWEEEQLQLEEQEQRLRQERDRQYRAEEQFATQEKSRREEQELWQEEEQKRRQERERKLR 1881
Query: 348 SEAFKK 353
E ++
Sbjct: 1882 EEHIRR 1887
Score = 59.3 bits (142), Expect = 5e-09
Identities = 78/365 (21%), Positives = 153/365 (41%), Gaps = 53/365 (14%)
Query: 7 QKQQAPRMDTPPPEERLEKQNEKLNNQEEETEFKELDGLREALANLRGLSEEERSEKAML 66
+++Q R D + + ++ ++L+ QE + +F+E + R EEE+ +
Sbjct: 1403 EREQQLRQDR---DRKFREEEQQLSRQERDRKFREEEQQVRRQERERKFLEEEQQLRQER 1459
Query: 67 RSRIEEQSQLICILKRRSDEALERCQILELLNAELEEKMMQEAEKLKAQGEYSRKLEERF 126
+ E+ QL L+ R ++ L R E + K ++E ++L+ Q E RK E+
Sbjct: 1460 HRKFREEEQL---LQEREEQQLHR--------QERDRKFLEEEQQLRRQ-ERDRKFREQE 1507
Query: 127 MTLAANHELMLRFKDEYKSENIKLREENEKLRLENSSLFSQALKDEEAKV-----LQLTV 181
+ L + + + + + E+ +L Q +D + K L+
Sbjct: 1508 LRSQEPERKFLEEEQQLHRQQRQRKFLQEEQQLRRQERGQQRRQDRDRKFREEEQLRQER 1567
Query: 182 RCEALTGELETLKERCAQDACQAQAREKELLELQSQ------QACTHTKETEQLRSQLQT 235
+ L+ + K R + + Q +E++ +E + Q Q + + R Q
Sbjct: 1568 EEQQLSRQERDRKFRLEEQKVRRQEQERKFMEDEQQLRRQEGQQQLRQERDRKFREDEQL 1627
Query: 236 LKQQHQQAVEQIAKAEETHSSLSQELQARLQTVT-----------REKEELLQLSIERGK 284
L+++ +Q Q+ + E L +E Q R Q RE+E+LLQ E+
Sbjct: 1628 LQEREEQ---QLHRQERDRKFLEEEPQLRRQEREQQLRHDRDRKFREEEQLLQEGEEQQL 1684
Query: 285 VLQNKQAEICQLEEKLEIANEDRKHALERFEQEAVAVDSNLRVRELQRKVDGIQKAYDEL 344
Q + + + E++L +RK F QE + LR +EL+RK + ++L
Sbjct: 1685 RRQERDRKFREEEQQLRRQERERK-----FLQE----EQQLRRQELERKF----REEEQL 1731
Query: 345 RLQSE 349
R ++E
Sbjct: 1732 RQETE 1736
Score = 58.9 bits (141), Expect = 7e-09
Identities = 84/372 (22%), Positives = 155/372 (41%), Gaps = 46/372 (12%)
Query: 9 QQAPRMDTPPPEERLEKQNEKLNNQEEE--TEFKELDGLREALANLRGLSEEERSEKAML 66
++ P ER ++ E+L +EE+ E +E +E R E ++ E+ +L
Sbjct: 1095 REEPEKRRRQERERQCREEEELQQEEEQLLREEREKRRRQELERQYREEEEVQQEEEQLL 1154
Query: 67 RSRIEEQSQLICILKRRSDEALERCQILELLNAELEEKMMQEAEKLKAQGEYSRKLEERF 126
R E KRR E + + E L E E+ + +E EK + + E + EE
Sbjct: 1155 REEPE---------KRRRQELERQYREEEELQQEEEQLLREEQEKRRQERERQYREEEEL 1205
Query: 127 MTLAANHELMLRFKDEYKSENIKLREENEKLR-LENSSLFSQALKDEEAKVLQLTVRCEA 185
+ R++DE + ++K + E EK + ++ ++ + ++E+ + L
Sbjct: 1206 Q----RQKRKQRYRDEDQRSDLKWQWEPEKENAVRDNKVYCKGRENEQFRQL-------- 1253
Query: 186 LTGELETLKERCAQDACQ-----AQAREKELLELQSQQACTHTKETEQLRSQLQ---TLK 237
E L++R +Q Q Q R++E + QQ H E EQL + Q +
Sbjct: 1254 ---EDSQLRDRQSQQDLQHLLGEQQERDREQERRRWQQRDRHFPEEEQLEREEQKEAKRR 1310
Query: 238 QQHQQAVEQIAKAEETHSSLSQELQARLQTVTREKEELLQLSIERGKVLQNKQAEICQLE 297
+ Q +Q+ + E QE + RE+E+LLQ E + L+ ++ + E
Sbjct: 1311 DRKSQEEKQLLREEREEKRRRQETDRKF----REEEQLLQEREE--QPLRRQERDRKFRE 1364
Query: 298 EKLEIANEDRK-----HALERFEQEAVAVDSNLRVRELQRKVDGIQKAYDELRLQSEAFK 352
E+L + RK L R E+E + ++R +R+ Q + R + +
Sbjct: 1365 EELRHQEQGRKFLEEEQRLRRQERERKFLKEEQQLRCQEREQQLRQDRDRKFREEEQQLS 1424
Query: 353 KHSLDLLSKERE 364
+ D +E E
Sbjct: 1425 RQERDRKFREEE 1436
Score = 58.9 bits (141), Expect = 7e-09
Identities = 86/403 (21%), Positives = 163/403 (40%), Gaps = 43/403 (10%)
Query: 2 RAPMLQKQQAPRMDTPPPEERLEKQNEKLNNQEEETEFKELDGLREALANLRGLSEEERS 61
R L++Q + EE+L ++ ++ QE E +++E + L+ R E++RS
Sbjct: 1162 RRQELERQYREEEELQQEEEQLLREEQEKRRQERERQYREEEELQRQKRKQRYRDEDQRS 1221
Query: 62 EKAMLRSRIEEQSQLICILKRRSDEALERCQILELLNAELEEKMMQE--AEKLKAQGEYS 119
+ L+ + E + + + + E Q +L +++L ++ Q+ L Q E
Sbjct: 1222 D---LKWQWEPEKENAVRDNKVYCKGRENEQFRQLEDSQLRDRQSQQDLQHLLGEQQERD 1278
Query: 120 RKLEERFMTLAANH-----ELMLRFKDEYKSENIKLREENEKLRLENSSLFSQALKD--- 171
R+ E R H +L + E K + K +EE + LR E + D
Sbjct: 1279 REQERRRWQQRDRHFPEEEQLEREEQKEAKRRDRKSQEEKQLLREEREEKRRRQETDRKF 1338
Query: 172 -EEAKVLQ-------------LTVRCEALTGELETLKERCAQDACQAQAREKELLELQSQ 217
EE ++LQ R E L + + K + + Q RE++ L+ + Q
Sbjct: 1339 REEEQLLQEREEQPLRRQERDRKFREEELRHQEQGRKFLEEEQRLRRQERERKFLKEEQQ 1398
Query: 218 QACTHTKE------TEQLRSQLQTLKQQH-----QQAVEQIAKAEETHSSLSQELQARLQ 266
C ++ + R + Q L +Q ++ +Q+ + E L +E Q R +
Sbjct: 1399 LRCQEREQQLRQDRDRKFREEEQQLSRQERDRKFREEEQQVRRQERERKFLEEEQQLRQE 1458
Query: 267 --TVTREKEELLQLSIERGKVLQNKQAEICQLEEKLEIANEDRK---HALERFEQEAVAV 321
RE+E+LLQ E+ Q + + + E++L DRK L E E +
Sbjct: 1459 RHRKFREEEQLLQEREEQQLHRQERDRKFLEEEQQLRRQERDRKFREQELRSQEPERKFL 1518
Query: 322 DSNLRVRELQRKVDGIQKAYDELRLQSEAFKKHSLDLLSKERE 364
+ ++ QR+ +Q+ R + ++ D +E E
Sbjct: 1519 EEEQQLHRQQRQRKFLQEEQQLRRQERGQQRRQDRDRKFREEE 1561
Score = 52.8 bits (125), Expect = 5e-07
Identities = 66/313 (21%), Positives = 130/313 (41%), Gaps = 45/313 (14%)
Query: 24 EKQNEKLNNQEEETEFKELDGL---REALANLRGLSEEERSEKAMLRSRIEEQSQLICIL 80
E++ ++L+ QE + +F E + +E LR + + E+ L EEQ L
Sbjct: 1630 EREEQQLHRQERDRKFLEEEPQLRRQEREQQLRHDRDRKFREEEQLLQEGEEQQ-----L 1684
Query: 81 KRRSDEALERCQILELLNAELEEKMMQEAEKLKAQGEYSRKLEERFMTLAANHELMLRFK 140
+R+ + R + +L E E K +QE ++L+ Q E RK E + LR +
Sbjct: 1685 RRQERDRKFREEEQQLRRQERERKFLQEEQQLRRQ-ELERKFREEEQLRQETEQEQLRRQ 1743
Query: 141 DEYKS--ENIKLREENEKLRLENSSLFSQALKDEEAKVLQLTVRCEALTGELETLKERCA 198
+ Y+ E +LR E E+ +L + ++E+ +
Sbjct: 1744 ERYRKILEEEQLRPEREEQQLRRQERDRKFREEEQLR----------------------- 1780
Query: 199 QDACQAQAREKELLELQSQQACTHTKETEQLRSQLQTLKQQHQQAVEQIAKAEETHSSLS 258
+E+E +L+SQ++ +E EQLR + + + + QQ + EE
Sbjct: 1781 --------QEREEQQLRSQESDRKFREEEQLRQEREEQQLRPQQRDGKYRWEEEQLQLEE 1832
Query: 259 QELQARLQTVTREKEELLQLSIERGKVLQNKQAEICQLEEKLEIANEDRKHALERFEQEA 318
QE + R + R+++ + + + ++ E+ Q EE+ +RK E ++
Sbjct: 1833 QEQRLRQE---RDRQYRAEEQFATQEKSRREEQELWQEEEQKRRQERERKLREEHIRRQQ 1889
Query: 319 VAVDSNLRVRELQ 331
+ +V E++
Sbjct: 1890 KEEQRHRQVGEIK 1902
Score = 49.3 bits (116), Expect = 6e-06
Identities = 86/386 (22%), Positives = 164/386 (42%), Gaps = 42/386 (10%)
Query: 8 KQQAPRMDTPPPEERLEKQNEKLNNQEEETEFKE-LDGLREALANLRGLSEEERSE-KAM 65
++Q R E+ E++ ++L +EEE ++ L E + L+EEE+ + +
Sbjct: 637 EEQEERRQQQLRREQQERREQRLKREEEEERLEQRLKREHEEERREQELAEEEQEQARER 696
Query: 66 LRSRIEE-QSQLICILKRRSDEALERCQILELLNAELEEKMMQEAEKLKAQGEYSRKLEE 124
++SRI + Q QL R + R + E E QE ++ + + E + EE
Sbjct: 697 IKSRIPKWQWQLESEADARQSKVYSRPRKQEGQRRRQE----QEEKRRRRESELQWQEEE 752
Query: 125 RFMTLAANHELMLRFKDEYKSENIKLREENEKLRLENSSLFSQALKDEEAKVLQLTVRCE 184
R E F ++++E E++E+ R S+ L+++ + L+ R +
Sbjct: 753 RAHRQQQEEEQRRDFTWQWQAE-----EKSERGRQRLSA--RPPLREQRERQLRAEERQQ 805
Query: 185 ALTGELETLKERCAQDACQAQAREKELLELQSQQACTHTKETEQL--------------R 230
L +E+ Q Q + REKEL L+ ++ + +QL R
Sbjct: 806 REQRFLPEEEEK-EQRRRQRREREKELQFLEEEEQLQRRERAQQLQEEEDGLQEDQERRR 864
Query: 231 SQLQTLKQQHQQAVEQIAKAEE----THSSLSQELQARLQTVTREKEELLQLSIERGK-- 284
SQ Q Q+ + +E+ K +L ++L+ Q + E+EEL + E+ +
Sbjct: 865 SQEQRRDQKWRWQLEEERKRRRHTLYAKPALQEQLRKEQQLLQEEEEELQREEREKRRRQ 924
Query: 285 --VLQNKQAEICQLEEKLEIANEDRKHALERFEQEAVAVDSNLRVRELQRKVDGIQKAYD 342
Q ++ E Q EE+ ++ E+R+ + + D L+ +E Q + +K
Sbjct: 925 EQERQYREEEQLQQEEE-QLLREEREKRRRQERERQYRKDKKLQQKEEQLLGEEPEKRRR 983
Query: 343 ELR----LQSEAFKKHSLDLLSKERE 364
+ R + E ++ LL +ERE
Sbjct: 984 QEREKKYREEEELQQEEEQLLREERE 1009
Score = 41.6 bits (96), Expect = 0.001
Identities = 39/146 (26%), Positives = 68/146 (46%), Gaps = 4/146 (2%)
Query: 6 LQKQQAPRMDTPPPEERLEKQNEKLNNQEEETEFKELDGLREAL--ANLRGLSEEERSEK 63
L++Q+ R + R E++ ++L +QE + +F+E + LR+ LR + +
Sbjct: 1764 LRRQERDRKFREEEQLRQEREEQQLRSQESDRKFREEEQLRQEREEQQLRPQQRDGKYRW 1823
Query: 64 AMLRSRIEEQSQLICILKRRSDEALERCQILELLNAELEEKMMQEAEKLKAQGEYSRKLE 123
+ ++EEQ Q + + R A E+ E E E+++ QE E+ + Q E RKL
Sbjct: 1824 EEEQLQLEEQEQRLRQERDRQYRAEEQFATQEKSRRE-EQELWQEEEQKRRQ-ERERKLR 1881
Query: 124 ERFMTLAANHELMLRFKDEYKSENIK 149
E + E R E KS+ K
Sbjct: 1882 EEHIRRQQKEEQRHRQVGEIKSQEGK 1907
>gi|222446603 golgi autoantigen, golgin subfamily a-like [Homo
sapiens]
Length = 668
Score = 77.0 bits (188), Expect = 3e-14
Identities = 84/354 (23%), Positives = 171/354 (48%), Gaps = 38/354 (10%)
Query: 20 EERLEKQNEKLNNQEEETEFKELDGLREALANLRGLSEEERSEKAMLRSRIEEQSQLICI 79
EE++ +Q EK+ EE+ + +E + +RE +R E+ R ++ M+ + E+
Sbjct: 299 EEKMWRQEEKIQEWEEKIQEQE-EKIREQEEKIREQEEKMRRQEEMMWEKEEKM------ 351
Query: 80 LKRRSDEAL----ERCQILELLNAELEEKMMQEAEKLKAQGEYSRKLEERFMTLAANHEL 135
RR +E + E+ + LE + E EEK+ + EK+ Q E R+ EE+ E
Sbjct: 352 --RRQEEMMWEKEEKMRRLEEMMWEKEEKIRELEEKMHEQ-EKIREQEEKRQEEEKIREQ 408
Query: 136 MLRFKDEYKS--ENIKLREENEKLRLENSSLFSQALKDEEAKVLQLTVRCEALTGELETL 193
R + E K + K+RE+ EK+R + ++ Q K E + ++ E
Sbjct: 409 EKRQEQEAKMWRQEEKIREQEEKIREQEKKMWRQEEKIHEQEKIR------------EEE 456
Query: 194 KERCAQDACQAQAREKELLELQSQQACTHTKETEQLRSQLQTLKQQHQQAVEQIAKAEET 253
K + ++ + + + +E E+ Q+ H E E++R Q + + +Q ++ +Q K E
Sbjct: 457 KRQEQEEMWRQEEKIREQEEIWRQKEKMH--EQEKIRKQEEKVWRQEEKMHDQEEKIREQ 514
Query: 254 HSSL-SQELQARLQTVT-REKEELLQLSIERGKVLQNKQAEICQLEEKLEIANEDRKHAL 311
+ QE + R Q RE+EE ++ E+ +++Q ++ ++ + EEK++ + R+
Sbjct: 515 EEKMWRQEEKIREQEEKIREQEEKIR---EQEEMMQEQEEKMGEQEEKMQEQEKMRRQEE 571
Query: 312 ERFEQEAVAVDSNLRVRELQRKVDGIQKAYDELRLQSEAFKKHSLDLLSKEREL 365
+ EQE + ++RE + K I + +++R Q E ++ + +E ++
Sbjct: 572 KIREQEEKIREQKEKIREQEEK---IWEQEEKIREQEEMMQEQEEKMWEQEEKM 622
Score = 68.9 bits (167), Expect = 7e-12
Identities = 70/323 (21%), Positives = 151/323 (46%), Gaps = 40/323 (12%)
Query: 20 EERLEKQNEKLNNQEEETEFKELDGLREALANLRGLSEEERSEKAMLRS--RIEEQSQLI 77
EE++ + EK++ QE+ +E + R+ +R + + E M R +I EQ + I
Sbjct: 376 EEKIRELEEKMHEQEK---IREQEEKRQEEEKIREQEKRQEQEAKMWRQEEKIREQEEKI 432
Query: 78 CILKRRSDEALERCQILELLNAELEEKMMQEAEKLKAQGEYSRKLEERFMTLAANHELML 137
+++ E+ E + EE+ QE E++ Q E R+ EE + HE
Sbjct: 433 REQEKKMWRQEEKIHEQEKIR---EEEKRQEQEEMWRQEEKIREQEEIWRQKEKMHEQEK 489
Query: 138 RFKDEYK--SENIKLREENEKLRLENSSLFSQA--LKDEEAKVLQLTVRCEALTGELETL 193
K E K + K+ ++ EK+R + ++ Q ++++E K+ +
Sbjct: 490 IRKQEEKVWRQEEKMHDQEEKIREQEEKMWRQEEKIREQEEKIREQ-------------- 535
Query: 194 KERCAQDACQAQAREKELLELQSQQACTHTKETEQLRSQLQTLKQQHQQAVEQIAKAEET 253
+E+ + Q +E+++ E + + +E E++R Q + +++Q ++ EQ K E
Sbjct: 536 EEKIREQEEMMQEQEEKMGEQEEKM-----QEQEKMRRQEEKIREQEEKIREQKEKIREQ 590
Query: 254 HSSLSQELQARLQTVTREKEELLQLSIERGKVLQNKQAEICQLEEKLEIANEDRKHALER 313
+ ++ + RE+EE++Q E+ + + ++ ++C+ EEK++ E + E+
Sbjct: 591 EEKIWEQ-----EEKIREQEEMMQ---EQEEKMWEQEEKMCEQEEKMQEQEEKMRRQEEK 642
Query: 314 -FEQEAVAVDSNLRVRELQRKVD 335
+EQE +++E Q ++
Sbjct: 643 MWEQEVRLRQQEEKMQEHQEHLE 665
Score = 62.4 bits (150), Expect = 6e-10
Identities = 73/374 (19%), Positives = 174/374 (46%), Gaps = 59/374 (15%)
Query: 20 EERLEKQNEKLNNQEEETEFKELDGLREALANLRGLSEEERSEKAML-----RSRIEEQS 74
+E L+++N KL + + E ++ E N++ L + K +L ++ +
Sbjct: 216 DEELKEKNAKLQEKLQLVESEK----SEIQLNVKELKRKLERAKLLLPQQQLQAEADHLG 271
Query: 75 QLICILKRRSDEALERCQILELLNAELEEKMMQEAEKLKAQGEYSRKLEERFMTLAANHE 134
+ + + + +E ++ LN + EEKM ++ EK++ E+ K++E+
Sbjct: 272 KELQSVSAKLQAQVEENELWNRLNQQQEEKMWRQEEKIQ---EWEEKIQEQ--------- 319
Query: 135 LMLRFKDEYKSENIKLREENEKLRLENSSLFSQALKDEEAKVLQLTVRCEALTGELETLK 194
+++ + + K+RE+ EK+R + ++ K+E+ + R E + E E
Sbjct: 320 -----EEKIREQEEKIREQEEKMRRQEEMMWE---KEEKMR------RQEEMMWEKEEKM 365
Query: 195 ERCAQDACQAQAREKELLELQSQQACTHTKETEQLRSQLQTLKQQHQQAVEQIAKA---E 251
R + + + + +EL E +Q +E E+ R + + +++Q ++ EQ AK E
Sbjct: 366 RRLEEMMWEKEEKIRELEEKMHEQE--KIREQEEKRQEEEKIREQEKRQ-EQEAKMWRQE 422
Query: 252 ETHSSLSQELQARLQTVTREKEELLQLSIERGKVLQNKQAEICQLEEKLEIANE-----D 306
E ++++ + + + R++E++ + R + + +Q E+ + EEK+ E +
Sbjct: 423 EKIREQEEKIREQEKKMWRQEEKIHEQEKIREEEKRQEQEEMWRQEEKIREQEEIWRQKE 482
Query: 307 RKHALER--------FEQEAVAVDSNLRVRELQRKV----DGIQKAYDELRLQSEAFKKH 354
+ H E+ + QE D ++RE + K+ + I++ +++R Q E ++
Sbjct: 483 KMHEQEKIRKQEEKVWRQEEKMHDQEEKIREQEEKMWRQEEKIREQEEKIREQEEKIREQ 542
Query: 355 SLDLLSKERELNGK 368
+++ ++ E G+
Sbjct: 543 E-EMMQEQEEKMGE 555
Score = 60.1 bits (144), Expect = 3e-09
Identities = 64/306 (20%), Positives = 145/306 (47%), Gaps = 56/306 (18%)
Query: 7 QKQQAPRMDTPPPEERLEKQNEKLNNQE-----EETEFKELDGLREALANLRGLSEEERS 61
+K+Q EE++ +Q EK+ QE +E + E + +RE EE+R
Sbjct: 409 EKRQEQEAKMWRQEEKIREQEEKIREQEKKMWRQEEKIHEQEKIRE---------EEKRQ 459
Query: 62 EKAML---RSRIEEQSQLICILKRRSDEALERCQILELLNAELEEKMMQEAEKLKAQGEY 118
E+ + +I EQ + + R+ ++ E+ +I + EEK+ ++ EK+ Q E
Sbjct: 460 EQEEMWRQEEKIREQEE----IWRQKEKMHEQEKI-----RKQEEKVWRQEEKMHDQEEK 510
Query: 119 SRKLEERFMTLAANHELMLRFKDEYKSENIKLREENEKLRLENSSLFSQALK-DEEAKVL 177
R+ EE+ M R +++ + + K+RE+ EK+R + + Q K E+ + +
Sbjct: 511 IREQEEK----------MWRQEEKIREQEEKIREQEEKIREQEEMMQEQEEKMGEQEEKM 560
Query: 178 QLTVRCEALTGELETLKERCAQDACQAQAREKELLELQSQQACTHTKETEQLRSQLQTLK 237
Q + ++ +E+ + + + +E+++ E + E++R Q + ++
Sbjct: 561 QEQEKMRRQEEKIREQEEKIREQKEKIREQEEKIWE-----------QEEKIREQEEMMQ 609
Query: 238 QQHQQAVEQIAKAEETHSSLSQELQARLQTVTREKEELLQLSIERGKVLQNKQAEICQLE 297
+Q ++ EQ EE +++Q + + + R++E++ + + L+ ++ ++ + +
Sbjct: 610 EQEEKMWEQ----EEKMCEQEEKMQEQEEKMRRQEEKMWEQEVR----LRQQEEKMQEHQ 661
Query: 298 EKLEIA 303
E LE A
Sbjct: 662 EHLEAA 667
>gi|205277396 dynactin 1 isoform 4 [Homo sapiens]
Length = 1139
Score = 75.1 bits (183), Expect = 1e-13
Identities = 78/341 (22%), Positives = 158/341 (46%), Gaps = 29/341 (8%)
Query: 48 ALANLRGLSEEERSEKAMLRSRIEEQSQLICILKRRSDEALERCQILELLNAELEEKMMQ 107
A+ L S+EE +A +R +EE+ + + LKR D+A + + LE +LE+
Sbjct: 72 AVPPLPSPSKEEEGLRAQVRD-LEEKLETLR-LKRAEDKA--KLKELEKHKIQLEQVQEW 127
Query: 108 EAEKLKAQGEYSRKLEERFMTLAANHELMLRFKDEYK--SENIKLREENEKLRLENSSLF 165
+++ + Q + R+L+E E R+ +E ++ I++ ++++ E +
Sbjct: 128 KSKMQEQQADLQRRLKEARKEAKEALEAKERYMEEMADTADAIEMATLDKEMAEERAESL 187
Query: 166 SQALKDEEAKVLQLTVRCEALTGELET-----------LKERCAQDAC--QAQAREKELL 212
Q ++ + +V +LT E L E+E LK+ Q+A A R ++L
Sbjct: 188 QQEVEALKERVDELTTDLEILKAEIEEKGSDGAASSYQLKQLEEQNARLKDALVRMRDLS 247
Query: 213 ELQSQQACTHTKETEQLRSQLQTLKQQHQQAVEQIAKAEETHSSLSQELQARLQTVTREK 272
+ Q+ K E+ +L+ ++QQ ++ E++++AE T L +++ A L
Sbjct: 248 SSEKQEHVKLQKLMEKKNQELEVVRQQRERLQEELSQAESTIDELKEQVDAALGA----- 302
Query: 273 EELLQLSIERGKVLQNKQAEICQLEEKLEIANEDRKHALERFEQEAVAVDSNL-----RV 327
EE++++ +R L+ K E+ + LE NE E + + + L RV
Sbjct: 303 EEMVEMLTDRNLNLEEKVRELRETVGDLEAMNEMNDELQENARETELELREQLDMAGARV 362
Query: 328 RELQRKVDGIQKAYDELRLQSEAFKKHSLDLLSKERELNGK 368
RE Q++V+ Q+ + + + +++ + L REL +
Sbjct: 363 REAQKRVEAAQETVADYQQTIKKYRQLTAHLQDVNRELTNQ 403
Score = 60.8 bits (146), Expect = 2e-09
Identities = 72/297 (24%), Positives = 127/297 (42%), Gaps = 25/297 (8%)
Query: 6 LQKQQAPRMDTPPPEERLEKQNEKLNNQEEETEFKEL-DGLREALANLRGLSEEERSEKA 64
+Q +Q + E++ + Q ++E E E + E +A+ E +K
Sbjct: 119 IQLEQVQEWKSKMQEQQADLQRRLKEARKEAKEALEAKERYMEEMADTADAIEMATLDKE 178
Query: 65 MLRSRIEEQSQLICILKRRSDEALERCQILELLNAELEEKMMQEAE---KLKAQGEYSRK 121
M R E Q + LK R DE LE+L AE+EEK A +LK E + +
Sbjct: 179 MAEERAESLQQEVEALKERVDELTTD---LEILKAEIEEKGSDGAASSYQLKQLEEQNAR 235
Query: 122 LEERFMTLA-------ANHELMLRFKDEYKSENIKLREENEKLRLENSSLFS--QALKDE 172
L++ + + H + + ++ E +R++ E+L+ E S S LK++
Sbjct: 236 LKDALVRMRDLSSSEKQEHVKLQKLMEKKNQELEVVRQQRERLQEELSQAESTIDELKEQ 295
Query: 173 EAKVLQLTVRCEALTGELETLKERCAQDACQAQAREKELLELQSQQACTHTKETE-QLRS 231
L E LT L+E+ + + + E + + + + +ETE +LR
Sbjct: 296 VDAALGAEEMVEMLTDRNLNLEEKVRE--LRETVGDLEAMNEMNDELQENARETELELRE 353
Query: 232 QLQTLKQQHQQAVEQIAKAEETHSSLSQ------ELQARLQTVTREKEELLQLSIER 282
QL + ++A +++ A+ET + Q +L A LQ V RE + S+ER
Sbjct: 354 QLDMAGARVREAQKRVEAAQETVADYQQTIKKYRQLTAHLQDVNRELTNQQEASVER 410
Score = 39.7 bits (91), Expect = 0.004
Identities = 45/200 (22%), Positives = 94/200 (47%), Gaps = 12/200 (6%)
Query: 170 KDEEAKVLQLTVRCEALTGELETLKERCAQDACQAQAREKELLELQSQQACTHTKETEQL 229
K+EE L + L +LETL+ + A+D + + EK ++L+ Q +K EQ
Sbjct: 81 KEEEG----LRAQVRDLEEKLETLRLKRAEDKAKLKELEKHKIQLEQVQE-WKSKMQEQQ 135
Query: 230 RSQLQTLKQQHQQAVEQIAKAEETHSSLSQELQARLQTVTREKEELLQLSIERGKVLQNK 289
+ LK+ ++A E + +A+E + + ++ T +KE ++ ER + LQ +
Sbjct: 136 ADLQRRLKEARKEAKEAL-EAKERYMEEMADTADAIEMATLDKE----MAEERAESLQQE 190
Query: 290 QAEICQLEEKLEIANEDRKHALERFEQEAVAVDSNLRVRELQRKVDGIQKAYDELRLQSE 349
+ + ++L E K +E + A S+ ++++L+ + ++ A +R S
Sbjct: 191 VEALKERVDELTTDLEILKAEIEEKGSDGAA--SSYQLKQLEEQNARLKDALVRMRDLSS 248
Query: 350 AFKKHSLDLLSKERELNGKL 369
+ K+ + L + N +L
Sbjct: 249 SEKQEHVKLQKLMEKKNQEL 268
>gi|205277392 dynactin 1 isoform 3 [Homo sapiens]
Length = 1253
Score = 75.1 bits (183), Expect = 1e-13
Identities = 78/341 (22%), Positives = 158/341 (46%), Gaps = 29/341 (8%)
Query: 48 ALANLRGLSEEERSEKAMLRSRIEEQSQLICILKRRSDEALERCQILELLNAELEEKMMQ 107
A+ L S+EE +A +R +EE+ + + LKR D+A + + LE +LE+
Sbjct: 186 AVPPLPSPSKEEEGLRAQVRD-LEEKLETLR-LKRAEDKA--KLKELEKHKIQLEQVQEW 241
Query: 108 EAEKLKAQGEYSRKLEERFMTLAANHELMLRFKDEYK--SENIKLREENEKLRLENSSLF 165
+++ + Q + R+L+E E R+ +E ++ I++ ++++ E +
Sbjct: 242 KSKMQEQQADLQRRLKEARKEAKEALEAKERYMEEMADTADAIEMATLDKEMAEERAESL 301
Query: 166 SQALKDEEAKVLQLTVRCEALTGELET-----------LKERCAQDAC--QAQAREKELL 212
Q ++ + +V +LT E L E+E LK+ Q+A A R ++L
Sbjct: 302 QQEVEALKERVDELTTDLEILKAEIEEKGSDGAASSYQLKQLEEQNARLKDALVRMRDLS 361
Query: 213 ELQSQQACTHTKETEQLRSQLQTLKQQHQQAVEQIAKAEETHSSLSQELQARLQTVTREK 272
+ Q+ K E+ +L+ ++QQ ++ E++++AE T L +++ A L
Sbjct: 362 SSEKQEHVKLQKLMEKKNQELEVVRQQRERLQEELSQAESTIDELKEQVDAALGA----- 416
Query: 273 EELLQLSIERGKVLQNKQAEICQLEEKLEIANEDRKHALERFEQEAVAVDSNL-----RV 327
EE++++ +R L+ K E+ + LE NE E + + + L RV
Sbjct: 417 EEMVEMLTDRNLNLEEKVRELRETVGDLEAMNEMNDELQENARETELELREQLDMAGARV 476
Query: 328 RELQRKVDGIQKAYDELRLQSEAFKKHSLDLLSKERELNGK 368
RE Q++V+ Q+ + + + +++ + L REL +
Sbjct: 477 REAQKRVEAAQETVADYQQTIKKYRQLTAHLQDVNRELTNQ 517
Score = 60.8 bits (146), Expect = 2e-09
Identities = 72/297 (24%), Positives = 127/297 (42%), Gaps = 25/297 (8%)
Query: 6 LQKQQAPRMDTPPPEERLEKQNEKLNNQEEETEFKEL-DGLREALANLRGLSEEERSEKA 64
+Q +Q + E++ + Q ++E E E + E +A+ E +K
Sbjct: 233 IQLEQVQEWKSKMQEQQADLQRRLKEARKEAKEALEAKERYMEEMADTADAIEMATLDKE 292
Query: 65 MLRSRIEEQSQLICILKRRSDEALERCQILELLNAELEEKMMQEAE---KLKAQGEYSRK 121
M R E Q + LK R DE LE+L AE+EEK A +LK E + +
Sbjct: 293 MAEERAESLQQEVEALKERVDELTTD---LEILKAEIEEKGSDGAASSYQLKQLEEQNAR 349
Query: 122 LEERFMTLA-------ANHELMLRFKDEYKSENIKLREENEKLRLENSSLFS--QALKDE 172
L++ + + H + + ++ E +R++ E+L+ E S S LK++
Sbjct: 350 LKDALVRMRDLSSSEKQEHVKLQKLMEKKNQELEVVRQQRERLQEELSQAESTIDELKEQ 409
Query: 173 EAKVLQLTVRCEALTGELETLKERCAQDACQAQAREKELLELQSQQACTHTKETE-QLRS 231
L E LT L+E+ + + + E + + + + +ETE +LR
Sbjct: 410 VDAALGAEEMVEMLTDRNLNLEEKVRE--LRETVGDLEAMNEMNDELQENARETELELRE 467
Query: 232 QLQTLKQQHQQAVEQIAKAEETHSSLSQ------ELQARLQTVTREKEELLQLSIER 282
QL + ++A +++ A+ET + Q +L A LQ V RE + S+ER
Sbjct: 468 QLDMAGARVREAQKRVEAAQETVADYQQTIKKYRQLTAHLQDVNRELTNQQEASVER 524
Score = 39.7 bits (91), Expect = 0.004
Identities = 45/200 (22%), Positives = 94/200 (47%), Gaps = 12/200 (6%)
Query: 170 KDEEAKVLQLTVRCEALTGELETLKERCAQDACQAQAREKELLELQSQQACTHTKETEQL 229
K+EE L + L +LETL+ + A+D + + EK ++L+ Q +K EQ
Sbjct: 195 KEEEG----LRAQVRDLEEKLETLRLKRAEDKAKLKELEKHKIQLEQVQE-WKSKMQEQQ 249
Query: 230 RSQLQTLKQQHQQAVEQIAKAEETHSSLSQELQARLQTVTREKEELLQLSIERGKVLQNK 289
+ LK+ ++A E + +A+E + + ++ T +KE ++ ER + LQ +
Sbjct: 250 ADLQRRLKEARKEAKEAL-EAKERYMEEMADTADAIEMATLDKE----MAEERAESLQQE 304
Query: 290 QAEICQLEEKLEIANEDRKHALERFEQEAVAVDSNLRVRELQRKVDGIQKAYDELRLQSE 349
+ + ++L E K +E + A S+ ++++L+ + ++ A +R S
Sbjct: 305 VEALKERVDELTTDLEILKAEIEEKGSDGAA--SSYQLKQLEEQNARLKDALVRMRDLSS 362
Query: 350 AFKKHSLDLLSKERELNGKL 369
+ K+ + L + N +L
Sbjct: 363 SEKQEHVKLQKLMEKKNQEL 382
>gi|13259508 dynactin 1 isoform 2 [Homo sapiens]
Length = 1144
Score = 75.1 bits (183), Expect = 1e-13
Identities = 78/341 (22%), Positives = 158/341 (46%), Gaps = 29/341 (8%)
Query: 48 ALANLRGLSEEERSEKAMLRSRIEEQSQLICILKRRSDEALERCQILELLNAELEEKMMQ 107
A+ L S+EE +A +R +EE+ + + LKR D+A + + LE +LE+
Sbjct: 72 AVPPLPSPSKEEEGLRAQVRD-LEEKLETLR-LKRAEDKA--KLKELEKHKIQLEQVQEW 127
Query: 108 EAEKLKAQGEYSRKLEERFMTLAANHELMLRFKDEYK--SENIKLREENEKLRLENSSLF 165
+++ + Q + R+L+E E R+ +E ++ I++ ++++ E +
Sbjct: 128 KSKMQEQQADLQRRLKEARKEAKEALEAKERYMEEMADTADAIEMATLDKEMAEERAESL 187
Query: 166 SQALKDEEAKVLQLTVRCEALTGELET-----------LKERCAQDAC--QAQAREKELL 212
Q ++ + +V +LT E L E+E LK+ Q+A A R ++L
Sbjct: 188 QQEVEALKERVDELTTDLEILKAEIEEKGSDGAASSYQLKQLEEQNARLKDALVRMRDLS 247
Query: 213 ELQSQQACTHTKETEQLRSQLQTLKQQHQQAVEQIAKAEETHSSLSQELQARLQTVTREK 272
+ Q+ K E+ +L+ ++QQ ++ E++++AE T L +++ A L
Sbjct: 248 SSEKQEHVKLQKLMEKKNQELEVVRQQRERLQEELSQAESTIDELKEQVDAALGA----- 302
Query: 273 EELLQLSIERGKVLQNKQAEICQLEEKLEIANEDRKHALERFEQEAVAVDSNL-----RV 327
EE++++ +R L+ K E+ + LE NE E + + + L RV
Sbjct: 303 EEMVEMLTDRNLNLEEKVRELRETVGDLEAMNEMNDELQENARETELELREQLDMAGARV 362
Query: 328 RELQRKVDGIQKAYDELRLQSEAFKKHSLDLLSKERELNGK 368
RE Q++V+ Q+ + + + +++ + L REL +
Sbjct: 363 REAQKRVEAAQETVADYQQTIKKYRQLTAHLQDVNRELTNQ 403
Score = 60.8 bits (146), Expect = 2e-09
Identities = 72/297 (24%), Positives = 127/297 (42%), Gaps = 25/297 (8%)
Query: 6 LQKQQAPRMDTPPPEERLEKQNEKLNNQEEETEFKEL-DGLREALANLRGLSEEERSEKA 64
+Q +Q + E++ + Q ++E E E + E +A+ E +K
Sbjct: 119 IQLEQVQEWKSKMQEQQADLQRRLKEARKEAKEALEAKERYMEEMADTADAIEMATLDKE 178
Query: 65 MLRSRIEEQSQLICILKRRSDEALERCQILELLNAELEEKMMQEAE---KLKAQGEYSRK 121
M R E Q + LK R DE LE+L AE+EEK A +LK E + +
Sbjct: 179 MAEERAESLQQEVEALKERVDELTTD---LEILKAEIEEKGSDGAASSYQLKQLEEQNAR 235
Query: 122 LEERFMTLA-------ANHELMLRFKDEYKSENIKLREENEKLRLENSSLFS--QALKDE 172
L++ + + H + + ++ E +R++ E+L+ E S S LK++
Sbjct: 236 LKDALVRMRDLSSSEKQEHVKLQKLMEKKNQELEVVRQQRERLQEELSQAESTIDELKEQ 295
Query: 173 EAKVLQLTVRCEALTGELETLKERCAQDACQAQAREKELLELQSQQACTHTKETE-QLRS 231
L E LT L+E+ + + + E + + + + +ETE +LR
Sbjct: 296 VDAALGAEEMVEMLTDRNLNLEEKVRE--LRETVGDLEAMNEMNDELQENARETELELRE 353
Query: 232 QLQTLKQQHQQAVEQIAKAEETHSSLSQ------ELQARLQTVTREKEELLQLSIER 282
QL + ++A +++ A+ET + Q +L A LQ V RE + S+ER
Sbjct: 354 QLDMAGARVREAQKRVEAAQETVADYQQTIKKYRQLTAHLQDVNRELTNQQEASVER 410
Score = 39.7 bits (91), Expect = 0.004
Identities = 45/200 (22%), Positives = 94/200 (47%), Gaps = 12/200 (6%)
Query: 170 KDEEAKVLQLTVRCEALTGELETLKERCAQDACQAQAREKELLELQSQQACTHTKETEQL 229
K+EE L + L +LETL+ + A+D + + EK ++L+ Q +K EQ
Sbjct: 81 KEEEG----LRAQVRDLEEKLETLRLKRAEDKAKLKELEKHKIQLEQVQE-WKSKMQEQQ 135
Query: 230 RSQLQTLKQQHQQAVEQIAKAEETHSSLSQELQARLQTVTREKEELLQLSIERGKVLQNK 289
+ LK+ ++A E + +A+E + + ++ T +KE ++ ER + LQ +
Sbjct: 136 ADLQRRLKEARKEAKEAL-EAKERYMEEMADTADAIEMATLDKE----MAEERAESLQQE 190
Query: 290 QAEICQLEEKLEIANEDRKHALERFEQEAVAVDSNLRVRELQRKVDGIQKAYDELRLQSE 349
+ + ++L E K +E + A S+ ++++L+ + ++ A +R S
Sbjct: 191 VEALKERVDELTTDLEILKAEIEEKGSDGAA--SSYQLKQLEEQNARLKDALVRMRDLSS 248
Query: 350 AFKKHSLDLLSKERELNGKL 369
+ K+ + L + N +L
Sbjct: 249 SEKQEHVKLQKLMEKKNQEL 268
>gi|13259510 dynactin 1 isoform 1 [Homo sapiens]
Length = 1278
Score = 75.1 bits (183), Expect = 1e-13
Identities = 78/341 (22%), Positives = 158/341 (46%), Gaps = 29/341 (8%)
Query: 48 ALANLRGLSEEERSEKAMLRSRIEEQSQLICILKRRSDEALERCQILELLNAELEEKMMQ 107
A+ L S+EE +A +R +EE+ + + LKR D+A + + LE +LE+
Sbjct: 206 AVPPLPSPSKEEEGLRAQVRD-LEEKLETLR-LKRAEDKA--KLKELEKHKIQLEQVQEW 261
Query: 108 EAEKLKAQGEYSRKLEERFMTLAANHELMLRFKDEYK--SENIKLREENEKLRLENSSLF 165
+++ + Q + R+L+E E R+ +E ++ I++ ++++ E +
Sbjct: 262 KSKMQEQQADLQRRLKEARKEAKEALEAKERYMEEMADTADAIEMATLDKEMAEERAESL 321
Query: 166 SQALKDEEAKVLQLTVRCEALTGELET-----------LKERCAQDAC--QAQAREKELL 212
Q ++ + +V +LT E L E+E LK+ Q+A A R ++L
Sbjct: 322 QQEVEALKERVDELTTDLEILKAEIEEKGSDGAASSYQLKQLEEQNARLKDALVRMRDLS 381
Query: 213 ELQSQQACTHTKETEQLRSQLQTLKQQHQQAVEQIAKAEETHSSLSQELQARLQTVTREK 272
+ Q+ K E+ +L+ ++QQ ++ E++++AE T L +++ A L
Sbjct: 382 SSEKQEHVKLQKLMEKKNQELEVVRQQRERLQEELSQAESTIDELKEQVDAALGA----- 436
Query: 273 EELLQLSIERGKVLQNKQAEICQLEEKLEIANEDRKHALERFEQEAVAVDSNL-----RV 327
EE++++ +R L+ K E+ + LE NE E + + + L RV
Sbjct: 437 EEMVEMLTDRNLNLEEKVRELRETVGDLEAMNEMNDELQENARETELELREQLDMAGARV 496
Query: 328 RELQRKVDGIQKAYDELRLQSEAFKKHSLDLLSKERELNGK 368
RE Q++V+ Q+ + + + +++ + L REL +
Sbjct: 497 REAQKRVEAAQETVADYQQTIKKYRQLTAHLQDVNRELTNQ 537
Score = 60.8 bits (146), Expect = 2e-09
Identities = 72/297 (24%), Positives = 127/297 (42%), Gaps = 25/297 (8%)
Query: 6 LQKQQAPRMDTPPPEERLEKQNEKLNNQEEETEFKEL-DGLREALANLRGLSEEERSEKA 64
+Q +Q + E++ + Q ++E E E + E +A+ E +K
Sbjct: 253 IQLEQVQEWKSKMQEQQADLQRRLKEARKEAKEALEAKERYMEEMADTADAIEMATLDKE 312
Query: 65 MLRSRIEEQSQLICILKRRSDEALERCQILELLNAELEEKMMQEAE---KLKAQGEYSRK 121
M R E Q + LK R DE LE+L AE+EEK A +LK E + +
Sbjct: 313 MAEERAESLQQEVEALKERVDELTTD---LEILKAEIEEKGSDGAASSYQLKQLEEQNAR 369
Query: 122 LEERFMTLA-------ANHELMLRFKDEYKSENIKLREENEKLRLENSSLFS--QALKDE 172
L++ + + H + + ++ E +R++ E+L+ E S S LK++
Sbjct: 370 LKDALVRMRDLSSSEKQEHVKLQKLMEKKNQELEVVRQQRERLQEELSQAESTIDELKEQ 429
Query: 173 EAKVLQLTVRCEALTGELETLKERCAQDACQAQAREKELLELQSQQACTHTKETE-QLRS 231
L E LT L+E+ + + + E + + + + +ETE +LR
Sbjct: 430 VDAALGAEEMVEMLTDRNLNLEEKVRE--LRETVGDLEAMNEMNDELQENARETELELRE 487
Query: 232 QLQTLKQQHQQAVEQIAKAEETHSSLSQ------ELQARLQTVTREKEELLQLSIER 282
QL + ++A +++ A+ET + Q +L A LQ V RE + S+ER
Sbjct: 488 QLDMAGARVREAQKRVEAAQETVADYQQTIKKYRQLTAHLQDVNRELTNQQEASVER 544
Score = 39.7 bits (91), Expect = 0.004
Identities = 45/200 (22%), Positives = 94/200 (47%), Gaps = 12/200 (6%)
Query: 170 KDEEAKVLQLTVRCEALTGELETLKERCAQDACQAQAREKELLELQSQQACTHTKETEQL 229
K+EE L + L +LETL+ + A+D + + EK ++L+ Q +K EQ
Sbjct: 215 KEEEG----LRAQVRDLEEKLETLRLKRAEDKAKLKELEKHKIQLEQVQE-WKSKMQEQQ 269
Query: 230 RSQLQTLKQQHQQAVEQIAKAEETHSSLSQELQARLQTVTREKEELLQLSIERGKVLQNK 289
+ LK+ ++A E + +A+E + + ++ T +KE ++ ER + LQ +
Sbjct: 270 ADLQRRLKEARKEAKEAL-EAKERYMEEMADTADAIEMATLDKE----MAEERAESLQQE 324
Query: 290 QAEICQLEEKLEIANEDRKHALERFEQEAVAVDSNLRVRELQRKVDGIQKAYDELRLQSE 349
+ + ++L E K +E + A S+ ++++L+ + ++ A +R S
Sbjct: 325 VEALKERVDELTTDLEILKAEIEEKGSDGAA--SSYQLKQLEEQNARLKDALVRMRDLSS 382
Query: 350 AFKKHSLDLLSKERELNGKL 369
+ K+ + L + N +L
Sbjct: 383 SEKQEHVKLQKLMEKKNQEL 402
>gi|239745089 PREDICTED: golgi autoantigen, golgin subfamily a-like
[Homo sapiens]
Length = 828
Score = 74.3 bits (181), Expect = 2e-13
Identities = 80/354 (22%), Positives = 170/354 (48%), Gaps = 29/354 (8%)
Query: 20 EERLEKQNEKLNNQEEETEFKELDGLREALANLRGLSEEERSEKAMLRSRIEEQSQLICI 79
EE L +Q +K+ ++EE +++ + LRE +R E+ R ++ LR + +E
Sbjct: 240 EEELREQEKKI-RKQEEKMWRQEERLREQEGKMREQEEKMRRQEKRLREQEKE------- 291
Query: 80 LKRRSDEALERCQILELLN--AELEEKMMQEAEKLKAQGEYSRKLEERF----MTLAANH 133
L+ + E E+ ++ E E EEKM ++ EK++ Q E + EER +
Sbjct: 292 LREQEKELREQKKLREQEEQMQEQEEKMWEQEEKMREQEEKMWRQEERLWEQEKQMREQE 351
Query: 134 ELMLRFKDEYKSENIKLREENEKLRLENSSLFSQALKDEEAKVLQLTVRCEALTGELETL 193
+ M ++ ++ +LRE+ E++R E ++ Q K +E + ++ R + + E ET+
Sbjct: 352 QKMRDQEERMWEQDERLREKEERMR-EQEKMWEQEEKMQEEE--RIREREKKMREEEETM 408
Query: 194 KERCAQDACQAQAR---EKELLELQSQQACTHTKETEQLRSQLQTLKQQHQQAVEQIAKA 250
+E+ ++ Q Q E+E E Q Q+ ++ E+L Q + +++Q ++ EQ K
Sbjct: 409 REQ--EEKMQKQEENMWEQEEKEWQQQRL---PEQKEKLWEQ-EKMQEQEEKIWEQEEKI 462
Query: 251 EETHSSLSQELQARLQTVTREKEELLQLSIERGKVLQNKQAEICQLEEKLEIANEDRKHA 310
+ QE + Q RE+E+ + E+ + +++++ ++ EE++ +E +
Sbjct: 463 RDQEEMWGQEKKMWRQEKMREQEDQMW---EQEEKMRDQEQKMWDQEERMWEQDERLREK 519
Query: 311 LERFEQEAVAVDSNLRVRELQRKVDGIQKAYDELRLQSEAFKKHSLDLLSKERE 364
ER ++ ++RE ++ + +K +D+ E + + +E E
Sbjct: 520 EERMREQKKMWQQEEKMREEKKTQEQEKKTWDQEEKMREEERMREREKKMREEE 573
Score = 67.0 bits (162), Expect = 3e-11
Identities = 85/356 (23%), Positives = 165/356 (46%), Gaps = 53/356 (14%)
Query: 20 EERLEKQNEKLNNQEEET-EFKELDGLREALANLRGLSEEERSEKAMLRSRIEEQSQLIC 78
EE + +Q EK+ QEE E +E + ++ L E+ EK + +++EQ + I
Sbjct: 405 EETMREQEEKMQKQEENMWEQEEKEWQQQRLP--------EQKEKLWEQEKMQEQEEKIW 456
Query: 79 IL--KRRSDEAL---ERCQILELLNAELEEKMMQEAEKLKAQGEYSRKLEERFMTLAANH 133
K R E + E+ + E E++M ++ EK++ Q + EER
Sbjct: 457 EQEEKIRDQEEMWGQEKKMWRQEKMREQEDQMWEQEEKMRDQEQKMWDQEERMW----EQ 512
Query: 134 ELMLRFKDEYKSENIKLREENEKLRLENSSLFSQALKDEEAKVLQLTVRCEALTGELETL 193
+ LR K+E E K+ ++ EK+R E + +++E K T E E E +
Sbjct: 513 DERLREKEERMREQKKMWQQEEKMREEKKT------QEQEKK----TWDQEEKMREEERM 562
Query: 194 KERCAQDACQAQAREKELLELQSQQACTHTKETEQLRSQLQTLKQQHQQAVEQIAKA-EE 252
+ER + + RE+E E+ +Q ++ E++R Q + + +Q ++ EQ K E+
Sbjct: 563 RER------EKKMREEE--EMMREQEEKMQEQEEKMREQEEKMWEQEEKMQEQEEKMWEQ 614
Query: 253 THSSLSQELQARLQTVTREKEELLQLSIERGKVLQNKQAEICQLEEKLEIANEDRKHALE 312
QE + ++Q E+EE++ E+ + +Q ++ ++ + EEK+ E +
Sbjct: 615 EEKMWEQEEEDKMQ----EQEEMMW---EQEEKMQEQEEKMWEQEEKMREQEEKMR---- 663
Query: 313 RFEQEAVAVDSNLRVRELQRKVDGIQKAYDELRLQSEAFKKHSLDLLSKERELNGK 368
EQE ++RE + K+ G + +++R Q E + + +E ++ G+
Sbjct: 664 --EQEEKMQGQEEKMREQEEKMQGQE---EKMREQEEKMRGQEEKMWGQEEKMWGQ 714
Score = 64.3 bits (155), Expect = 2e-10
Identities = 64/309 (20%), Positives = 143/309 (46%), Gaps = 21/309 (6%)
Query: 40 KELDGLREALANLRGLSEEERSEKAMLRSRI---EEQSQLICILKRRSDEALERCQIL-- 94
KE D L L +EE + + A L+ ++ E + I + + LER + L
Sbjct: 166 KERDALSLELYRNTITNEELKKKNAELQEKLRLAESEKSEIQLNVKELKRKLERAKFLLP 225
Query: 95 ELLNAELEEKMMQEAEKLKAQGEYSRKLEERFMTLAANHELMLRFKDEYKSENIKLREEN 154
++ L+E+M ++ E+L+ Q + RK EE+ M R ++ + + K+RE+
Sbjct: 226 QVQTNTLQEEMWRQEEELREQEKKIRKQEEK----------MWRQEERLREQEGKMREQE 275
Query: 155 EKLRLENSSLFSQALKDEEAKVLQLTVRCEALTGELETLKERCAQDACQAQAREKELLEL 214
EK+R + L Q ++E + + +R + E E + + + + + +E E
Sbjct: 276 EKMRRQEKRLREQ---EKELREQEKELREQKKLREQEEQMQEQEEKMWEQEEKMREQEEK 332
Query: 215 QSQQACTHTKETEQLRSQLQTLKQQHQQAVEQIAKAEETHSSLSQELQARLQTVTREKEE 274
+Q ++ +Q+R Q Q ++ Q ++ EQ + E + ++ + Q ++EE
Sbjct: 333 MWRQEERLWEQEKQMREQEQKMRDQEERMWEQDERLREKEERMREQEKMWEQEEKMQEEE 392
Query: 275 LLQLSIERGKVLQNKQAEICQLEEKLEIANEDRKHALERFEQEAVAVDSNLRVRELQRKV 334
++ ER K ++ ++ + + EEK++ E+ E+ Q+ + ++ E ++
Sbjct: 393 RIR---EREKKMREEEETMREQEEKMQKQEENMWEQEEKEWQQQRLPEQKEKLWEQEKMQ 449
Query: 335 DGIQKAYDE 343
+ +K +++
Sbjct: 450 EQEEKIWEQ 458
Score = 53.5 bits (127), Expect = 3e-07
Identities = 40/181 (22%), Positives = 94/181 (51%), Gaps = 10/181 (5%)
Query: 20 EERLEKQNEKLNNQEEETEFKELDGLREALANLRGLSEEERSEKAMLRSRIEEQSQLICI 79
EE++++Q EK+ QEE+ +++ + ++E + +EE+ + +++EQ +++
Sbjct: 580 EEKMQEQEEKMREQEEKM-WEQEEKMQEQEEKM--WEQEEKMWEQEEEDKMQEQEEMMWE 636
Query: 80 LKRRSDEALERCQILELLNAELEEKMMQEAEKLKAQGEYSRKLEERFMTLAANHELMLRF 139
+ + E E+ E E EEKM ++ EK++ Q E R+ EE+ + E M
Sbjct: 637 QEEKMQEQEEKMWEQEEKMREQEEKMREQEEKMQGQEEKMREQEEK---MQGQEEKMREQ 693
Query: 140 KDEYKSENIKLREENEKLRLENSSLFSQ-ALKDEEAKVLQLTVRCEALTGELETLKERCA 198
+++ + + K+ + EK+ + ++ Q ++++E ++ + E + L +ERC+
Sbjct: 694 EEKMRGQEEKMWGQEEKMWGQEEKMWGQEEMREKEERIRD---QKEKMQERLPEHEERCS 750
Query: 199 Q 199
+
Sbjct: 751 E 751
>gi|239745079 PREDICTED: Putative golgin subfamily A member 6-like
protein 6 [Homo sapiens]
Length = 724
Score = 74.3 bits (181), Expect = 2e-13
Identities = 70/331 (21%), Positives = 155/331 (46%), Gaps = 40/331 (12%)
Query: 20 EERLEKQNEKLNNQEE-----ETEFKELDGLREALANLRGLSEEERSEKAMLRSRIEEQS 74
EE + ++ EK+ QEE E + +EL+ +R EE+R E+ +R + + Q
Sbjct: 416 EEMMWEKEEKMRRQEEMMWEKEEKIRELEEKMHEQEKIRE-QEEKRQEEEKIREQEKRQE 474
Query: 75 QLICILKRRSDEALERCQILELLNAELEEKMMQEAEKLKAQGEYSRKLEERFMTLAANHE 134
Q + ++ E+ + E E EEKM ++ EK+ Q + + + + E
Sbjct: 475 QEAKMWRQE-----EKIREQEEKIREQEEKMWRQEEKIHEQEKIREEEKRQEQEEMWRQE 529
Query: 135 LMLRFKDEYKSENIKLREENEKLRLENSSLFSQ---------ALKDEEAKVLQLTVRCEA 185
+R ++E + K+ E+ EK+R + ++ Q ++++E KV + +
Sbjct: 530 EKIREQEEIWRQKEKIHEQEEKIRKQEEKMWRQEEKMHDQEEKIREQEEKVWRQEEKIRE 589
Query: 186 LTGELETLKERCAQDACQAQAREKELLELQSQQACTHTKETEQLRSQLQTLKQQHQQAVE 245
++ +E+ + Q +E+++ E Q ++ C ++ E+++ Q + +++Q ++ E
Sbjct: 590 QEEKIREQEEKIREQEEMTQEQEEKMGE-QEEKMC---EQEEKMQEQEEKMRRQEEKIRE 645
Query: 246 QIAKAEETHSSLSQELQARLQTVTREKEELLQLSIERGKVLQNKQAEICQLEEKLEIANE 305
Q K E + RE+EE++Q E+ + + ++ ++C+ EEK++ E
Sbjct: 646 QEKKIREQEEKI------------REQEEMMQ---EQEEKMWEQEEKMCEQEEKMQEQEE 690
Query: 306 DRKHALER-FEQEAVAVDSNLRVRELQRKVD 335
+ E+ +EQE +++E Q ++
Sbjct: 691 KMRRQEEKMWEQEVRLRQQEEKMQEHQEHLE 721
Score = 61.6 bits (148), Expect = 1e-09
Identities = 74/375 (19%), Positives = 172/375 (45%), Gaps = 60/375 (16%)
Query: 20 EERLEKQNEKLNNQEEETEFKELDGLREALANLRGLSEEERSEKAML-----RSRIEEQS 74
+E L+++N KL + + E ++ E N++ L + K +L ++ +
Sbjct: 277 DEELKEKNAKLQEKLQLVESEK----SEIQLNVKELKRKLERAKLLLPQQQLQAEADHLG 332
Query: 75 QLICILKRRSDEALERCQILELLNAELEEKMMQEAEKLKAQGEYSRKLEERFMTLAANHE 134
+ + + + +E ++ LN + EEKM ++ EK++ E+ K++E+
Sbjct: 333 KELQSVSAKLQAQVEENELWNRLNQQQEEKMWRQEEKIQ---EWEEKIQEQ--------- 380
Query: 135 LMLRFKDEYKSENIKLREENEKLRLENSSLFSQALKDEEAKVLQLTVRCEALTGELETLK 194
+++ + + K+RE+ EK+R + ++ K+E+ + R E + E E
Sbjct: 381 -----EEKIREQEEKIREQEEKMRRQEEMMWE---KEEKMR------RQEEMMWEKEEKM 426
Query: 195 ERCAQDACQAQAREKELLELQSQQACTHTKETEQLRSQLQTLKQQHQQAVEQIAKA---E 251
R + + + + +EL E +Q +E E+ R + + +++Q ++ EQ AK E
Sbjct: 427 RRQEEMMWEKEEKIRELEEKMHEQE--KIREQEEKRQEEEKIREQEKRQ-EQEAKMWRQE 483
Query: 252 ETHSSLSQELQARLQTVTREKEELLQLSIERGKVLQNKQAEICQLEEKL----------- 300
E ++++ + + + R++E++ + R + + +Q E+ + EEK+
Sbjct: 484 EKIREQEEKIREQEEKMWRQEEKIHEQEKIREEEKRQEQEEMWRQEEKIREQEEIWRQKE 543
Query: 301 ---EIANEDRKHALERFEQEAVAVDSNLRVRELQRKV----DGIQKAYDELRLQSEAFKK 353
E + RK + + QE D ++RE + KV + I++ +++R Q E ++
Sbjct: 544 KIHEQEEKIRKQEEKMWRQEEKMHDQEEKIREQEEKVWRQEEKIREQEEKIREQEEKIRE 603
Query: 354 HSLDLLSKERELNGK 368
++ ++ E G+
Sbjct: 604 QE-EMTQEQEEKMGE 617
Score = 60.8 bits (146), Expect = 2e-09
Identities = 70/305 (22%), Positives = 140/305 (45%), Gaps = 59/305 (19%)
Query: 7 QKQQAPRMDTPPPEERLEKQNEKLNNQEE-----ETEFKELDGLREALANLRGLSEEERS 61
+K+Q EE++ +Q EK+ QEE E + E + +RE EE+R
Sbjct: 470 EKRQEQEAKMWRQEEKIREQEEKIREQEEKMWRQEEKIHEQEKIRE---------EEKRQ 520
Query: 62 EKAML---RSRIEEQSQLICILKRRSDEALERCQILELLNAELEEKMMQEAEKLKAQGEY 118
E+ + +I EQ + I K + E E+ + + EEKM ++ EK+ Q E
Sbjct: 521 EQEEMWRQEEKIREQEE-IWRQKEKIHEQEEKIR-------KQEEKMWRQEEKMHDQEEK 572
Query: 119 SRKLEERFMTLAANHELMLRFKDEYKSENIKLREENEKLRLENSSLFSQALKDEEAKVLQ 178
R+ EE+ + R +++ + + K+RE+ EK+R + Q EE Q
Sbjct: 573 IREQEEK----------VWRQEEKIREQEEKIREQEEKIREQEEMTQEQ----EEKMGEQ 618
Query: 179 LTVRCEALTGELETLKERCAQDACQAQAREKELLELQSQQACTHTKETEQLRSQLQTLKQ 238
CE +E Q+ + R++E + Q ++ ++ E++R Q + +++
Sbjct: 619 EEKMCE---------QEEKMQEQEEKMRRQEEKIREQEKKI---REQEEKIREQEEMMQE 666
Query: 239 QHQQAVEQIAKAEETHSSLSQELQARLQTVTREKEELLQLSIERGKVLQNKQAEICQLEE 298
Q ++ EQ EE +++Q + + + R++E++ + + L+ ++ ++ + +E
Sbjct: 667 QEEKMWEQ----EEKMCEQEEKMQEQEEKMRRQEEKMWEQEVR----LRQQEEKMQEHQE 718
Query: 299 KLEIA 303
LE A
Sbjct: 719 HLEAA 723
>gi|154350244 hypothetical protein LOC79632 isoform 2 [Homo sapiens]
Length = 971
Score = 72.8 bits (177), Expect = 5e-13
Identities = 98/391 (25%), Positives = 173/391 (44%), Gaps = 58/391 (14%)
Query: 23 LEKQN--EKLNNQEEETEFK-ELDGLREALANLRGLSEEE---------------RSEKA 64
LE+Q+ +KLN +E++ + + EL+ L+E L + + +E S +
Sbjct: 392 LEEQHNKDKLNLEEDKNQLQQELENLKEVLEDKLNTANQEIGHLQDMVRKSEQGLGSAEG 451
Query: 65 MLRSRIEEQSQLICILKRRSDEALERCQILELLNAELEEKMMQEAEKLKAQGEYSRKLEE 124
++ S + Q +L L D E L + ELE++ Q E + A E EE
Sbjct: 452 LIASLQDSQERLQNELDLTKDSLKETKDALLNVEGELEQERQQHEETIAAMKE-----EE 506
Query: 125 RFMTLAANHELMLRFKDEYKSENIKLREENEKLRLENS----SLFSQAL--KDEEAKVLQ 178
+ H+L +++ + + E KLREE LRL++ S SQ L KD E +
Sbjct: 507 KLKVDKMAHDLEIKWTENLRQECSKLREE---LRLQHEEDKKSAMSQLLQLKDREKNAAR 563
Query: 179 LT--VRCEALTGELETLKERCAQDACQAQAREKELLELQSQQACTHTKETEQLRSQLQTL 236
+ + E L ++ LK+ Q+Q L +LQ+Q T+E ++L +L+ L
Sbjct: 564 DSWQKKVEDLLNQISLLKQNLEIQLSQSQT---SLQQLQAQ----FTQERQRLTQELEEL 616
Query: 237 KQQHQQAVEQIAKAE----ETHSSLSQELQARLQTVTREKE--ELLQLSIERGKVLQNKQ 290
++QHQQ + + +A +T ++ Q L+ ++K EL L + ++ +
Sbjct: 617 EEQHQQRHKSLKEAHVLAFQTMEEEKEKEQRALENHLQQKHSAELQSLKDAHRESMEGFR 676
Query: 291 AEICQLEEKLEIANEDRKHAL------ERFEQEAVAVD--SNLRVRELQRKVDGIQKAYD 342
E+ Q + L ED A+ E Q A A+D + +EL ++++ D
Sbjct: 677 IEMEQELQTLRFELEDEGKAMLASLRSELNHQHAAAIDLLRHNHHQELAAAKMELERSID 736
Query: 343 ELRLQSEAFKKHSLDLLSKERELNGKLRHLS 373
R QS K+H + + EL + H+S
Sbjct: 737 ISRRQS---KEHICRITDLQEELRHREHHIS 764
Score = 53.1 bits (126), Expect = 4e-07
Identities = 82/367 (22%), Positives = 155/367 (42%), Gaps = 36/367 (9%)
Query: 14 MDTPPPEERLEKQNEKLNNQEEETEFKELDG----LREALANLRGLSEEERSEKAMLRSR 69
+DT + ++ + + ++E KE G LR+ + L+ + + E L +
Sbjct: 143 LDTLKRSQLFTAESLQASKEKEADLRKEFQGQEAILRKTIGKLKTELQMVQDEAGSLLDK 202
Query: 70 IEEQSQLICI-------LKRRSDEALERCQILELLNAELEEKMMQEAEKLKAQG-EYSRK 121
++ + I L+++ D+A E L + E+E ++ E+L+ Q + K
Sbjct: 203 CQKLQTALAIAENNVQVLQKQLDDAKEGEMALLSKHKEVESELAAARERLQQQASDLVLK 262
Query: 122 LEERFMTLAANHELMLRFKDEYKSENIKLREENEKLRLENSSLFSQALKDEEAKVLQLTV 181
M A + KD +SE ++ E +L E + L S+ +E + Q+
Sbjct: 263 ASHIGMLQATQMTQEVTIKD-LESEKSRVNERLSQLEEERAFLRSKTQSLDEEQKQQI-- 319
Query: 182 RCEALTGELETLKERCAQDACQAQAREKELLELQSQQACTHTKETEQLRSQLQTLKQQHQ 241
LE K+ Q + E+EL LQS+ T+ E L+ L +H
Sbjct: 320 --------LELEKKVNEAKRTQQEYYERELKNLQSRLEEEVTQLNEAHSKTLEELAWKHH 371
Query: 242 QAVEQIAKAEETHSSLSQELQARLQTVTREKEELLQLSIERGKVLQNKQAEICQ--LEEK 299
A+E + HS+ ++ + +LQ E+ +L++E K ++ E + LE+K
Sbjct: 372 MAIEAV------HSNAIRD-KKKLQMDLEEQHNKDKLNLEEDKNQLQQELENLKEVLEDK 424
Query: 300 LEIANEDRKHALERFEQEAVAVDS-NLRVRELQRKVDGIQKAYDELRLQSEAFKKHSLDL 358
L AN++ H + + + S + LQ D ++ +EL L ++ K+ L
Sbjct: 425 LNTANQEIGHLQDMVRKSEQGLGSAEGLIASLQ---DSQERLQNELDLTKDSLKETKDAL 481
Query: 359 LSKEREL 365
L+ E EL
Sbjct: 482 LNVEGEL 488
Score = 32.0 bits (71), Expect = 0.93
Identities = 50/218 (22%), Positives = 96/218 (44%), Gaps = 18/218 (8%)
Query: 153 ENEKLRLENSSLFSQALKDEEAKVLQLTVRCEALTGELETLKERCAQDACQAQAREKELL 212
E K R+E+ L ++A +++ ++ E + + E Q Q Q + + L
Sbjct: 10 EAYKHRVEDMQLCAEA--QHVQRIVTMSREVEEIRRKFEEKLRSFGQ--LQVQFEKDKRL 65
Query: 213 ELQSQQACTHTKETEQLRSQLQTLKQQHQQAVEQ-IAKAEETHSSLSQELQARLQTVTRE 271
L+ QA + E L+SQ Q H +V + KAEE H + L L+ + E
Sbjct: 66 ALEDLQAAHRREIQELLKSQ-----QDHSASVNKGQEKAEELHRMEVESLNKMLEELRLE 120
Query: 272 KEELLQLSIERGKVLQNKQAEICQLEEKLEIANEDRKHALERFEQEAVAVDSNLRVRELQ 331
+++L++ GK+ NK E +L+ + E Q + +++LR +E Q
Sbjct: 121 RKKLIE--DYEGKL--NKAQSF--YERELDTLKRSQLFTAESL-QASKEKEADLR-KEFQ 172
Query: 332 RKVDGIQKAYDELRLQSEAFKKHSLDLLSKERELNGKL 369
+ ++K +L+ + + + + LL K ++L L
Sbjct: 173 GQEAILRKTIGKLKTELQMVQDEAGSLLDKCQKLQTAL 210
Score = 29.6 bits (65), Expect = 4.6
Identities = 24/101 (23%), Positives = 49/101 (48%), Gaps = 6/101 (5%)
Query: 20 EERLEKQNEKLNNQEEETEFKELDGLREALANLRGLSEEERSEKAMLRSRIEEQSQLICI 79
++ ++ +E ++ +E EFK + LR + + + EE EK ++R E Q+I
Sbjct: 767 DKEVQHLHENISALTKELEFKGKEILRIRSESNQQIRLEEMEEKYLMRESKPEDIQMITE 826
Query: 80 LKRRSDEALERCQILELLNAELEEKMMQEAEKLKAQGEYSR 120
LK ER QI++ L +E+ + E + + +++
Sbjct: 827 LKAM---LTERDQIIKKL---IEDNKFYQLELVNRETNFNK 861
>gi|154350226 hypothetical protein LOC79632 isoform 1 [Homo sapiens]
Length = 1140
Score = 72.8 bits (177), Expect = 5e-13
Identities = 98/391 (25%), Positives = 173/391 (44%), Gaps = 58/391 (14%)
Query: 23 LEKQN--EKLNNQEEETEFK-ELDGLREALANLRGLSEEE---------------RSEKA 64
LE+Q+ +KLN +E++ + + EL+ L+E L + + +E S +
Sbjct: 512 LEEQHNKDKLNLEEDKNQLQQELENLKEVLEDKLNTANQEIGHLQDMVRKSEQGLGSAEG 571
Query: 65 MLRSRIEEQSQLICILKRRSDEALERCQILELLNAELEEKMMQEAEKLKAQGEYSRKLEE 124
++ S + Q +L L D E L + ELE++ Q E + A E EE
Sbjct: 572 LIASLQDSQERLQNELDLTKDSLKETKDALLNVEGELEQERQQHEETIAAMKE-----EE 626
Query: 125 RFMTLAANHELMLRFKDEYKSENIKLREENEKLRLENS----SLFSQAL--KDEEAKVLQ 178
+ H+L +++ + + E KLREE LRL++ S SQ L KD E +
Sbjct: 627 KLKVDKMAHDLEIKWTENLRQECSKLREE---LRLQHEEDKKSAMSQLLQLKDREKNAAR 683
Query: 179 LT--VRCEALTGELETLKERCAQDACQAQAREKELLELQSQQACTHTKETEQLRSQLQTL 236
+ + E L ++ LK+ Q+Q L +LQ+Q T+E ++L +L+ L
Sbjct: 684 DSWQKKVEDLLNQISLLKQNLEIQLSQSQT---SLQQLQAQ----FTQERQRLTQELEEL 736
Query: 237 KQQHQQAVEQIAKAE----ETHSSLSQELQARLQTVTREKE--ELLQLSIERGKVLQNKQ 290
++QHQQ + + +A +T ++ Q L+ ++K EL L + ++ +
Sbjct: 737 EEQHQQRHKSLKEAHVLAFQTMEEEKEKEQRALENHLQQKHSAELQSLKDAHRESMEGFR 796
Query: 291 AEICQLEEKLEIANEDRKHAL------ERFEQEAVAVD--SNLRVRELQRKVDGIQKAYD 342
E+ Q + L ED A+ E Q A A+D + +EL ++++ D
Sbjct: 797 IEMEQELQTLRFELEDEGKAMLASLRSELNHQHAAAIDLLRHNHHQELAAAKMELERSID 856
Query: 343 ELRLQSEAFKKHSLDLLSKERELNGKLRHLS 373
R QS K+H + + EL + H+S
Sbjct: 857 ISRRQS---KEHICRITDLQEELRHREHHIS 884
Score = 53.1 bits (126), Expect = 4e-07
Identities = 82/367 (22%), Positives = 155/367 (42%), Gaps = 36/367 (9%)
Query: 14 MDTPPPEERLEKQNEKLNNQEEETEFKELDG----LREALANLRGLSEEERSEKAMLRSR 69
+DT + ++ + + ++E KE G LR+ + L+ + + E L +
Sbjct: 263 LDTLKRSQLFTAESLQASKEKEADLRKEFQGQEAILRKTIGKLKTELQMVQDEAGSLLDK 322
Query: 70 IEEQSQLICI-------LKRRSDEALERCQILELLNAELEEKMMQEAEKLKAQG-EYSRK 121
++ + I L+++ D+A E L + E+E ++ E+L+ Q + K
Sbjct: 323 CQKLQTALAIAENNVQVLQKQLDDAKEGEMALLSKHKEVESELAAARERLQQQASDLVLK 382
Query: 122 LEERFMTLAANHELMLRFKDEYKSENIKLREENEKLRLENSSLFSQALKDEEAKVLQLTV 181
M A + KD +SE ++ E +L E + L S+ +E + Q+
Sbjct: 383 ASHIGMLQATQMTQEVTIKD-LESEKSRVNERLSQLEEERAFLRSKTQSLDEEQKQQI-- 439
Query: 182 RCEALTGELETLKERCAQDACQAQAREKELLELQSQQACTHTKETEQLRSQLQTLKQQHQ 241
LE K+ Q + E+EL LQS+ T+ E L+ L +H
Sbjct: 440 --------LELEKKVNEAKRTQQEYYERELKNLQSRLEEEVTQLNEAHSKTLEELAWKHH 491
Query: 242 QAVEQIAKAEETHSSLSQELQARLQTVTREKEELLQLSIERGKVLQNKQAEICQ--LEEK 299
A+E + HS+ ++ + +LQ E+ +L++E K ++ E + LE+K
Sbjct: 492 MAIEAV------HSNAIRD-KKKLQMDLEEQHNKDKLNLEEDKNQLQQELENLKEVLEDK 544
Query: 300 LEIANEDRKHALERFEQEAVAVDS-NLRVRELQRKVDGIQKAYDELRLQSEAFKKHSLDL 358
L AN++ H + + + S + LQ D ++ +EL L ++ K+ L
Sbjct: 545 LNTANQEIGHLQDMVRKSEQGLGSAEGLIASLQ---DSQERLQNELDLTKDSLKETKDAL 601
Query: 359 LSKEREL 365
L+ E EL
Sbjct: 602 LNVEGEL 608
Score = 46.2 bits (108), Expect = 5e-05
Identities = 82/361 (22%), Positives = 149/361 (41%), Gaps = 58/361 (16%)
Query: 22 RLEKQNEKLNNQEEETEFKELDGLREALANLRGLSEEERSEKAMLRSRIEEQSQLICILK 81
+L K LN + +E E A+ L+ EEE ++ + E + I K
Sbjct: 50 QLTKVIYALNTKNDEHE--------SAIQALKDAHEEE------IQQILAETREKILQYK 95
Query: 82 RRSDEALERCQILELLNAELEEKMMQEAEKLKAQGEYSRKLEERFMTLAANHELMLRFKD 141
+ E L+ + +++L + LE+ + + + L Y ++E+ M L A + + R
Sbjct: 96 SKVTEELDLRRKIQVLESSLEDHIKMKQQALTEFEAYKHRVED--MQLCAEAQHVQRIVT 153
Query: 142 EYKSENIKLREENEKLRLENSSLFSQALKDEEAKVLQLTVRCEALTGELETLKERCAQDA 201
+ R+ EKLR L Q KD+ + L EL ++ +
Sbjct: 154 MSREVEEIRRKFEEKLR-SFGQLQVQFEKDKRLALEDLQAAHRREIQELLKSQQDHSASV 212
Query: 202 CQAQAREKELLELQSQQACTHTKETEQLRSQLQTLKQQHQQAVEQI-AKAEETHSSLSQE 260
+ Q + +EL H E E L L+ L+ + ++ +E K + S +E
Sbjct: 213 NKGQEKAEEL----------HRMEVESLNKMLEELRLERKKLIEDYEGKLNKAQSFYERE 262
Query: 261 LQA--RLQTVTREKEELLQLSIER----GKVLQNKQA----EICQLEEKLEIANEDRKHA 310
L R Q T E LQ S E+ K Q ++A I +L+ +L++ ++
Sbjct: 263 LDTLKRSQLFTAES---LQASKEKEADLRKEFQGQEAILRKTIGKLKTELQMVQDEAGSL 319
Query: 311 LERFE--QEAVAVDSNLRVRELQRKVDGIQKAYDELRLQSEAFKKHSLDLLSKERELNGK 368
L++ + Q A+A+ N V+ LQ+++D K+ + LLSK +E+ +
Sbjct: 320 LDKCQKLQTALAIAEN-NVQVLQKQLDDA--------------KEGEMALLSKHKEVESE 364
Query: 369 L 369
L
Sbjct: 365 L 365
>gi|157738667 FYVE and coiled-coil domain containing 1 [Homo sapiens]
Length = 1478
Score = 72.4 bits (176), Expect = 6e-13
Identities = 86/380 (22%), Positives = 167/380 (43%), Gaps = 36/380 (9%)
Query: 22 RLEKQNEKLNNQEEETEFKELDG----LREALANLRGLSEEERSEKAMLRSRIEEQSQLI 77
R K+ K E+E + +G LRE + + L+E E L S+ ++Q+QLI
Sbjct: 685 RKAKEAMKAQMAEKEAILQSKEGECQQLREEVEQCQQLAEARHRELRALESQCQQQTQLI 744
Query: 78 CILKRRS----------DEALERCQILELLNAELE------EKMMQEAEKLKAQGEYSRK 121
+L +EA E L L A+LE +++ + L+A+ +
Sbjct: 745 EVLTAEKGQQGVGPPTDNEARELAAQLALSQAQLEVHQGEVQRLQAQVVDLQAKMRAALD 804
Query: 122 LEERFMTLAANHELMLRFKDEYKSENIKLREENEKLRLENSSLFSQALKDEEAKVLQLTV 181
+++ + + E +LR E+K+ +L+E+NE L + Q + E A +
Sbjct: 805 DQDKVQSQLSMAEAVLR---EHKTLVQQLKEQNEALNRAHVQELLQCSEREGALQEERAD 861
Query: 182 RCEALTGELETLKERCAQDACQAQAREKELLELQSQQACTHTKETEQLRSQLQTLKQQHQ 241
+ EL L+E +Q C ++ + E ELQ Q +T +T +L Q+ L + +
Sbjct: 862 EAQQREEELRALQEELSQAKCSSEEAQLEHAELQEQLHRANT-DTAELGIQVCALTVEKE 920
Query: 242 Q-------AVEQIAKAEETHSSLSQELQARLQTVTREKEEL---LQLSIERGKVLQNKQA 291
+ AV+++ A+E S + L+ ++ + +EKE L L+ + L QA
Sbjct: 921 RVEEALACAVQELQDAKEAASREREGLERQVAGLQQEKESLQEKLKAAKAAAGSLPGLQA 980
Query: 292 EICQLEEKLEIANEDRKHALE--RFEQEAVAVDSNLRVRELQRKVDGIQKAYDELRLQSE 349
++ Q E++ + E L +F+ A +D R++ + ++ +E Q +
Sbjct: 981 QLAQAEQRAQSLQEAAHQELNTLKFQLSAEIMDYQSRLKNAGEECKSLRGQLEEQGRQLQ 1040
Query: 350 AFKKHSLDLLSKERELNGKL 369
A ++ L + + ++ KL
Sbjct: 1041 AAEEAVEKLKATQADMGEKL 1060
Score = 47.8 bits (112), Expect = 2e-05
Identities = 87/386 (22%), Positives = 163/386 (42%), Gaps = 29/386 (7%)
Query: 6 LQKQQAPRMDTPPPEERLEK--QNEKLNNQEEETEFKELDGLREALANLRGLSEEERSEK 63
LQKQ T + L+ Q +L E+E ++ LR + L+ L++E + +
Sbjct: 298 LQKQWEVTQATQNTVKELQTCLQGLELGAAEKEEDYHT--ALRRLESMLQPLAQELEATR 355
Query: 64 AMLRSRIEEQSQL---ICILKRRSDEALERCQILELLNAELEEKMMQEAEKLKAQGEYSR 120
L + + + + + ++++D A + E + ++ ++M + EKL+A
Sbjct: 356 DSLDKKNQHLASFPGWLAMAQQKADTASDTKGRQEPIPSDAAQEMQELGEKLQALERERT 415
Query: 121 KLEERFMTLAANHELM---LRFKDEYKSENIKLREENEKLRLENSSLFSQA--LKDEEAK 175
K+EE +A E + L+ K++ ++ +L +E L+ E S +A L +
Sbjct: 416 KVEEVNRQQSAQLEQLVKELQLKEDARASLERLVKEMAPLQEELSGKGQEADQLWRRLQE 475
Query: 176 VLQLTVRCEALTGELETLKER------CAQDACQAQAREKELLELQSQQACTHTKETEQL 229
+L T E EL K++ + ++ R+ + LE Q Q H + E+
Sbjct: 476 LLAHTSSWEEELAELRREKKQQQEEKELLEQEVRSLTRQLQFLETQLAQVSQHVSDLEEQ 535
Query: 230 RSQLQTLKQQHQQAV---EQIAKAEETHSSLSQELQARLQTVTREKEELLQLSIERGKVL 286
+ QL K Q V E++A ++ E L V +E E + L
Sbjct: 536 KKQLIQDKDHLSQQVGMLERLAGPPGPELPVAGEKNEALVPVNSSLQEAWGKPEEEQRGL 595
Query: 287 QNKQAEICQLEEKLEIANEDRKHALERFEQEAVAVDSNLRVRELQRKVDGIQKAYDELRL 346
Q Q + +++E + E+ + A E+E V R + L+ K+ +Q Y L+
Sbjct: 596 QEAQLDDTKVQEGSQ--EEELRQANRELEKELQNVVG--RNQLLEGKLQALQADYQALQ- 650
Query: 347 QSEAFKKHSLDLLSKERELNGKLRHL 372
Q E+ + SL L E+ +RHL
Sbjct: 651 QRESAIQGSLASLEAEQ---ASIRHL 673
Score = 43.1 bits (100), Expect = 4e-04
Identities = 91/390 (23%), Positives = 159/390 (40%), Gaps = 50/390 (12%)
Query: 1 MRAPMLQKQQAPRMDTPPPEERLEKQNEKLNN--------QEEETEFKELDGLREALANL 52
M P+ Q+ +A R + L+K+N+ L + Q++ + G +E + +
Sbjct: 343 MLQPLAQELEATR-------DSLDKKNQHLASFPGWLAMAQQKADTASDTKGRQEPIPSD 395
Query: 53 RGLSEEERSEKAMLRSRIEEQSQLICILKRRS---DEALERCQILELLNAELEEKMMQEA 109
+E EK R E++++ + +++S ++ ++ Q+ E A LE + + A
Sbjct: 396 AAQEMQELGEKLQALER--ERTKVEEVNRQQSAQLEQLVKELQLKEDARASLERLVKEMA 453
Query: 110 ---EKLKAQGEYSRKLEERFMTLAANHELMLRFKDEYKSENIKLREENEKLRLENSSLFS 166
E+L +G+ + +L R L A+ E + E + +EE E L E SL
Sbjct: 454 PLQEELSGKGQEADQLWRRLQELLAHTSSWEEELAELRREKKQQQEEKELLEQEVRSLTR 513
Query: 167 QALKDEEAKVLQLTVRCEALTGELETLKERCAQDACQAQAREKELLELQSQQACTHTKET 226
Q L+ E ++ Q++ +LE K++ QD + L L E
Sbjct: 514 Q-LQFLETQLAQVSQH----VSDLEEQKKQLIQDKDHLSQQVGMLERLAGPPG----PEL 564
Query: 227 EQLRSQLQTLKQQHQQAVEQIAKAEETHSSLSQELQ---ARLQTVTREKEELLQLSIERG 283
+ + L + E K EE L QE Q ++Q ++E EEL Q + E
Sbjct: 565 PVAGEKNEALVPVNSSLQEAWGKPEEEQRGL-QEAQLDDTKVQEGSQE-EELRQANRELE 622
Query: 284 KVLQNKQAEICQLEEKLEIANEDRKHALERFEQEAVAVDSNLRVRELQRKV-----DGIQ 338
K LQN LE KL+ D + +Q A+ +L E ++ D ++
Sbjct: 623 KELQNVVGRNQLLEGKLQALQAD----YQALQQRESAIQGSLASLEAEQASIRHLGDQME 678
Query: 339 KAYDELRLQSEAFKKHSLD----LLSKERE 364
+ +R EA K + L SKE E
Sbjct: 679 ASLLAVRKAKEAMKAQMAEKEAILQSKEGE 708
>gi|12667788 myosin, heavy polypeptide 9, non-muscle [Homo sapiens]
Length = 1960
Score = 72.0 bits (175), Expect = 8e-13
Identities = 95/416 (22%), Positives = 173/416 (41%), Gaps = 61/416 (14%)
Query: 6 LQKQQAPRMDTPPPEERLEKQNEKLNNQEEET-----EFKELDGLREALANL--RGLSEE 58
L+ ++A R + L ++ E L + E+T +EL RE N+ + L EE
Sbjct: 1120 LESERASRNKAEKQKRDLGEELEALKTELEDTLDSTAAQQELRSKREQEVNILKKTLEEE 1179
Query: 59 ERSEKAMLRSRIEEQSQLICILKRRSDEALERCQILELLNAELEEKMMQEAEKLKA---- 114
++ +A ++ ++ SQ + L + ++ LE LE + + A ++K
Sbjct: 1180 AKTHEAQIQEMRQKHSQAVEELAEQLEQTKRVKANLEKAKQTLENERGELANEVKVLLQG 1239
Query: 115 --QGEYSRK-LEERFMTLAANHELMLRFKDEYKSENIKLREE--------------NEKL 157
E+ RK +E + L R + E + KL+ E + KL
Sbjct: 1240 KGDSEHKRKKVEAQLQELQVKFNEGERVRTELADKVTKLQVELDNVTGLLSQSDSKSSKL 1299
Query: 158 RLENSSLFSQA------LKDEEAKVLQLTVRCEALTGELETLKERCAQDACQAQAREKEL 211
+ S+L SQ L++E + L L+ + + + E + +E+ ++ EK++
Sbjct: 1300 TKDFSALESQLQDTQELLQEENRQKLSLSTKLKQVEDEKNSFREQLEEEEEAKHNLEKQI 1359
Query: 212 LELQSQQA-----------CTHTKET--EQLRSQLQTLKQQHQQAVEQIAKAEETHSSLS 258
L +Q A C T E +L+ L+ L Q+H++ V K E+T + L
Sbjct: 1360 ATLHAQVADMKKKMEDSVGCLETAEEVKRKLQKDLEGLSQRHEEKVAAYDKLEKTKTRLQ 1419
Query: 259 QELQARLQTVTREKEELLQLSIERGKVLQNKQAEICQL--EEKLEIANEDRKHALERFEQ 316
QEL L + +++ L+ KQ + QL EEK A K+A ER
Sbjct: 1420 QELDDLLVDLDHQRQSACN--------LEKKQKKFDQLLAEEKTISA----KYAEERDRA 1467
Query: 317 EAVAVDSNLRVRELQRKVDGIQKAYDELRLQSEAFKKHSLDLLSKERELNGKLRHL 372
EA A + + L R ++ + EL ++ F+ DL+S + ++ + L
Sbjct: 1468 EAEAREKETKALSLARALEEAMEQKAELERLNKQFRTEMEDLMSSKDDVGKSVHEL 1523
Score = 71.6 bits (174), Expect = 1e-12
Identities = 89/373 (23%), Positives = 164/373 (43%), Gaps = 35/373 (9%)
Query: 4 PMLQKQQAPRMDTPPPEERLEKQNEKLNNQEEETEFKELDG--------LREALANLRGL 55
P+LQ + EE ++ + ++L + TE + L L+E L L
Sbjct: 836 PLLQVSRQEEEMMAKEEELVKVREKQLAAENRLTEMETLQSQLMAEKLQLQEQLQAETEL 895
Query: 56 SEEERSEKAMLRSRIEEQSQLICILKRRSDEALERCQILELLNAELEEKMMQEAEKLKAQ 115
E +A L ++ +E ++ L+ R +E ERCQ L+ ++++ + + E+L+ +
Sbjct: 896 CAEAEELRARLTAKKQELEEICHDLEARVEEEEERCQHLQAEKKKMQQNIQELEEQLEEE 955
Query: 116 GEYSRKLEERFMTLAANHELMLRFKDEYKSENIKLREENEKLRLENSSLFSQALKDEEAK 175
+KL+ +T A + + + + +N KL +E +KL + + F+ L +EE K
Sbjct: 956 ESARQKLQLEKVTTEAKLKKLEEEQIILEDQNCKLAKE-KKLLEDRIAEFTTNLTEEEEK 1014
Query: 176 VLQLTVRCEALTGELETLKERCAQDACQAQAREKELLELQSQQACTHTKETEQLRSQLQT 235
L + L+ER ++ Q Q EK +L+ ++ L Q+
Sbjct: 1015 SKSLAKLKNKHEAMITDLEERLRREEKQRQELEKTRRKLEG--------DSTDLSDQIAE 1066
Query: 236 LKQQHQQAVEQIAKAEETHSSLSQELQARLQTVTREKEELLQLSIERGKVLQNKQAEICQ 295
L+ Q + Q+AK EE ELQA L R +EE Q ++ K+ + +++I +
Sbjct: 1067 LQAQIAELKMQLAKKEE-------ELQAAL---ARVEEEAAQKNMALKKI-RELESQISE 1115
Query: 296 LEEKLEIANEDRKHALERFEQEAVAVDSNLRVRELQRKVDGIQKAYDELRLQSEAFKKHS 355
L+E LE R A + ++ + + EL+ +D A ELR + E
Sbjct: 1116 LQEDLESERASRNKAEK--QKRDLGEELEALKTELEDTLDS-TAAQQELRSKRE----QE 1168
Query: 356 LDLLSKERELNGK 368
+++L K E K
Sbjct: 1169 VNILKKTLEEEAK 1181
Score = 67.8 bits (164), Expect = 2e-11
Identities = 83/341 (24%), Positives = 159/341 (46%), Gaps = 25/341 (7%)
Query: 7 QKQQAPRMDTPPPEERLEKQNEKLNNQEEETEFKELDGLREALANLR-GLSEEERSEKAM 65
QK Q ++ T ++LE++ L +Q + KE L + +A L+EEE K++
Sbjct: 960 QKLQLEKVTTEAKLKKLEEEQIILEDQNCKLA-KEKKLLEDRIAEFTTNLTEEEEKSKSL 1018
Query: 66 LRSRIEEQSQLICILKRRSDEALERCQILELLNAELEEKMMQEAEKLKAQGEYSRKLEER 125
+ + + ++ + + +R E +R Q LE +LE ++++ E ++ E
Sbjct: 1019 AKLKNKHEAMITDLEERLRREEKQR-QELEKTRRKLEGDSTDLSDQI---AELQAQIAEL 1074
Query: 126 FMTLAANHE----LMLRFKDEYKSENIKLREENEKLRLENS-SLFSQALKDEEAKVLQLT 180
M LA E + R ++E +N+ L++ E LE+ S + L+ E A +
Sbjct: 1075 KMQLAKKEEELQAALARVEEEAAQKNMALKKIRE---LESQISELQEDLESERASRNKAE 1131
Query: 181 VRCEALTGELETLKERCAQDACQAQAREKELLELQSQQAC----THTKETEQLRSQLQTL 236
+ L ELE LK +D + A ++EL + Q+ T +E + +Q+Q +
Sbjct: 1132 KQKRDLGEELEALKTEL-EDTLDSTAAQQELRSKREQEVNILKKTLEEEAKTHEAQIQEM 1190
Query: 237 KQQHQQAVEQIAKAEETHSSLSQELQARLQTVTREKEELLQLSIERGKVLQNKQAEICQL 296
+Q+H QAVE++A+ E + L+ QT+ E+ EL KVL + +
Sbjct: 1191 RQKHSQAVEELAEQLEQTKRVKANLEKAKQTLENERGEL----ANEVKVLLQGKGDSEHK 1246
Query: 297 EEKLEIANEDRKHALERFEQEAVAVDSNLRVRELQRKVDGI 337
+K+E ++ + ++ E E V + +V +LQ ++D +
Sbjct: 1247 RKKVEAQLQELQ--VKFNEGERVRTELADKVTKLQVELDNV 1285
Score = 63.5 bits (153), Expect = 3e-10
Identities = 85/381 (22%), Positives = 167/381 (43%), Gaps = 47/381 (12%)
Query: 21 ERLEKQNEKLNNQEEETEFKELDGLREALANL----RGLSEEERSEKAMLRSRIEEQSQL 76
++LEK +L QE + +LD R++ NL + + EK + EE+ +
Sbjct: 1409 DKLEKTKTRLQ-QELDDLLVDLDHQRQSACNLEKKQKKFDQLLAEEKTISAKYAEERDRA 1467
Query: 77 ICILKRRSDEALERCQILELLNAELEEKMMQEAEKLKAQGEYSRKLEERFMTLAANHELM 136
+ + +AL L LEE M Q+AE + ++ ++E+ L ++ + +
Sbjct: 1468 EAEAREKETKALS-------LARALEEAMEQKAELERLNKQFRTEMED----LMSSKDDV 1516
Query: 137 LRFKDEYKSENIKLREENEKLRLENSSLFSQALKDEEAKVLQLTVRCEA--------LTG 188
+ E + L ++ E+++ + L + E+AK L+L V +A L G
Sbjct: 1517 GKSVHELEKSKRALEQQVEEMKTQLEELEDELQATEDAK-LRLEVNLQAMKAQFERDLQG 1575
Query: 189 ELETLKERCAQDACQAQAREKELLELQSQQ--ACTHTKETEQ----LRSQLQTLKQQHQQ 242
E +E+ Q Q + E EL + + Q+ A K+ E L + + + + +
Sbjct: 1576 RDEQSEEKKKQLVRQVREMEAELEDERKQRSMAVAARKKLEMDLKDLEAHIDSANKNRDE 1635
Query: 243 AVEQIAKAEETHSSLSQELQARLQTVTREKEELLQLSIERGKVLQNKQAEICQLEEKLEI 302
A++Q+ K + +EL +EE+L + E K L++ +AE+ QL+E+L
Sbjct: 1636 AIKQLRKLQAQMKDCMRELD----DTRASREEILAQAKENEKKLKSMEAEMIQLQEELAA 1691
Query: 303 ANEDRKHALERFEQEAVAVDSN-----LRVRELQRKVDGIQKAYDEL-------RLQSEA 350
A ++ A + ++ A + ++ L + E +R I + +EL L ++
Sbjct: 1692 AERAKRQAQQERDELADEIANSSGKGALALEEKRRLEARIAQLEEELEEEQGNTELINDR 1751
Query: 351 FKKHSLDLLSKERELNGKLRH 371
KK +L + +LN + H
Sbjct: 1752 LKKANLQIDQINTDLNLERSH 1772
Score = 57.8 bits (138), Expect = 2e-08
Identities = 67/286 (23%), Positives = 129/286 (45%), Gaps = 21/286 (7%)
Query: 6 LQKQQAPRMDTPPPEERLEKQNEKLNNQEEETEFKELDGLREALANLRGLSEEERSEKAM 65
L+K QA D + E++ Q +E E K L+ A + L EE + +
Sbjct: 1640 LRKLQAQMKDCMRELDDTRASREEILAQAKENEKK----LKSMEAEMIQLQEELAAAERA 1695
Query: 66 LRSRIEEQSQLICILKRRSDE---ALERCQILELLNAELEEKMMQEAEKLKAQGEYSRKL 122
R +E+ +L + S + ALE + LE A+LEE++ +E + + +K
Sbjct: 1696 KRQAQQERDELADEIANSSGKGALALEEKRRLEARIAQLEEELEEEQGNTELINDRLKKA 1755
Query: 123 EERFMTLAANHELMLRFKDEYKSENIK--LREENEKLRLENSSLFSQALKDEEAKVLQLT 180
+ + N +L L K+EN + L +N++L+++ + +A + L
Sbjct: 1756 NLQIDQI--NTDLNLERSHAQKNENARQQLERQNKELKVKLQEMEGTVKSKYKASITALE 1813
Query: 181 VRCEALTGELET-LKERCAQDAC-QAQAREKELLEL------QSQQACTHTKETEQLRSQ 232
+ L +L+ KER Q AC Q + EK+L ++ + + A + + ++ ++
Sbjct: 1814 AKIAQLEEQLDNETKER--QAACKQVRRTEKKLKDVLLQVDDERRNAEQYKDQADKASTR 1871
Query: 233 LQTLKQQHQQAVEQIAKAEETHSSLSQELQARLQTVTREKEELLQL 278
L+ LK+Q ++A E+ +A + L +EL+ +T E+ L
Sbjct: 1872 LKQLKRQLEEAEEEAQRANASRRKLQRELEDATETADAMNREVSSL 1917
Score = 28.9 bits (63), Expect = 7.8
Identities = 21/108 (19%), Positives = 49/108 (45%), Gaps = 2/108 (1%)
Query: 20 EERLEKQNEKLNNQEEETEF--KELDGLREALANLRGLSEEERSEKAMLRSRIEEQSQLI 77
E ++ + E+L+N+ +E + K++ + L ++ ++ER + + ++ S +
Sbjct: 1813 EAKIAQLEEQLDNETKERQAACKQVRRTEKKLKDVLLQVDDERRNAEQYKDQADKASTRL 1872
Query: 78 CILKRRSDEALERCQILELLNAELEEKMMQEAEKLKAQGEYSRKLEER 125
LKR+ +EA E Q +L+ ++ E A L+ +
Sbjct: 1873 KQLKRQLEEAEEEAQRANASRRKLQRELEDATETADAMNREVSSLKNK 1920
>gi|13124879 smooth muscle myosin heavy chain 11 isoform SM1A [Homo
sapiens]
Length = 1972
Score = 72.0 bits (175), Expect = 8e-13
Identities = 86/359 (23%), Positives = 152/359 (42%), Gaps = 40/359 (11%)
Query: 6 LQKQQAPRMDTPPPEERLEKQNEKLNNQEEETEFKELDGLREALANLRGLSEEERSEKAM 65
L++++A R +LEK + ++ E E +D L+ R L EE S+
Sbjct: 959 LEEEEAARQKL-----QLEKVTAEAKIKKLEDEILVMDDQNNKLSKERKLLEERISDLTT 1013
Query: 66 LRSRIEEQSQLICILKRRSDEALERCQILELLNAELEEKMMQEAEKLKAQ---------- 115
+ EE+++ + LK + + + ++ + EEK QE EKLK +
Sbjct: 1014 NLAEEEEKAKNLTKLKNKHESMISELEV----RLKKEEKSRQELEKLKRKLEGDASDFHE 1069
Query: 116 --GEYSRKLEERFMTLAANHE----LMLRFKDEYKSENIKLREENEKLRLENS-SLFSQA 168
+ ++ E M LA E + R DE +N L++ E LE S +
Sbjct: 1070 QIADLQAQIAELKMQLAKKEEELQAALARLDDEIAQKNNALKKIRE---LEGHISDLQED 1126
Query: 169 LKDEEAKVLQLTVRCEALTGELETLKERCAQDACQAQAREKELLELQSQQACTHTK---- 224
L E A + + L ELE LK +D + A ++EL + Q+ K
Sbjct: 1127 LDSERAARNKAEKQKRDLGEELEALKTEL-EDTLDSTATQQELRAKREQEVTVLKKALDE 1185
Query: 225 ETEQLRSQLQTLKQQHQQAVEQIAKAEETHSSLSQELQARLQTVTREKEELLQLSIERGK 284
ET +Q+Q ++Q+H QAVE++ + E L QT+ +E +L +
Sbjct: 1186 ETRSHEAQVQEMRQKHAQAVEELTEQLEQFKRAKANLDKNKQTLEKENADL----AGELR 1241
Query: 285 VLQNKQAEICQLEEKLEIANEDRKHALERFEQEAVAVDSNLRVRELQRKVDGIQKAYDE 343
VL + E+ ++KLE ++ + + E + N +V +LQ +V+ + +E
Sbjct: 1242 VLGQAKQEVEHKKKKLEAQVQELQSKCS--DGERARAELNDKVHKLQNEVESVTGMLNE 1298
Score = 63.2 bits (152), Expect = 4e-10
Identities = 92/409 (22%), Positives = 179/409 (43%), Gaps = 47/409 (11%)
Query: 6 LQKQQAPRMDTPPPEERLEKQNEKLNNQEEET-----EFKELDGLREALANL--RGLSEE 58
L ++A R + L ++ E L + E+T +EL RE + + L EE
Sbjct: 1127 LDSERAARNKAEKQKRDLGEELEALKTELEDTLDSTATQQELRAKREQEVTVLKKALDEE 1186
Query: 59 ERSEKAMLRSRIEEQSQLICILKRRSDEALERCQILELLNAELEEKMMQEAEKLKAQGEY 118
RS +A ++ ++ +Q + L + ++ L+ LE++ A +L+ G+
Sbjct: 1187 TRSHEAQVQEMRQKHAQAVEELTEQLEQFKRAKANLDKNKQTLEKENADLAGELRVLGQA 1246
Query: 119 SRKLEERFMTLAAN-HELMLRFKD------EYKSENIKLREENE--------------KL 157
+++E + L A EL + D E + KL+ E E KL
Sbjct: 1247 KQEVEHKKKKLEAQVQELQSKCSDGERARAELNDKVHKLQNEVESVTGMLNEAEGKAIKL 1306
Query: 158 RLENSSLFSQA------LKDEEAKVLQLTVRCEALTGELETLKERCAQDACQAQAREKEL 211
+ +SL SQ L++E + L ++ + L E +L+++ ++ Q E+ +
Sbjct: 1307 AKDVASLSSQLQDTQELLQEETRQKLNVSTKLRQLEEERNSLQDQLDEEMEAKQNLERHI 1366
Query: 212 LELQSQQACTHTKETEQLRSQLQTL---KQQHQQAVEQIAKAEETHSSLSQELQARLQTV 268
L Q + + K+ + S ++ L K++ Q+ +E + + E ++ +L+ +
Sbjct: 1367 STLNIQLSDSK-KKLQDFASTVEALEEGKKRFQKEIENLTQQYEEKAAAYDKLEKTKNRL 1425
Query: 269 TREKEELL-QLSIERGKV--LQNKQAEICQL--EEKLEIANEDRKHALERFEQEAVAVDS 323
+E ++L+ L +R V L+ KQ + QL EEK N K+A ER EA A +
Sbjct: 1426 QQELDDLVVDLDNQRQLVSNLEKKQRKFDQLLAEEK----NISSKYADERDRAEAEAREK 1481
Query: 324 NLRVRELQRKVDGIQKAYDELRLQSEAFKKHSLDLLSKERELNGKLRHL 372
+ L R ++ +A +EL ++ K DL+S + ++ + L
Sbjct: 1482 ETKALSLARALEEALEAKEELERTNKMLKAEMEDLVSSKDDVGKNVHEL 1530
Score = 59.3 bits (142), Expect = 5e-09
Identities = 96/398 (24%), Positives = 178/398 (44%), Gaps = 75/398 (18%)
Query: 20 EERLEKQNEKLNNQEEETEFKELDGLR-----EALA-----NLRGLSEEERSEKAMLRSR 69
E ++E+ +L E+E + E LR +AL +L+ E+ ++ L+ +
Sbjct: 1538 ETQMEEMKTQLEELEDELQATEDAKLRLEVNMQALKGQFERDLQARDEQNEEKRRQLQRQ 1597
Query: 70 IEE----------QSQLICILKRRSDEALERCQILELLNAELEEKMMQEAEKLKAQ-GEY 118
+ E Q L K++ + L+ ++ + E+ +++ KL+AQ ++
Sbjct: 1598 LHEYETELEDERKQRALAAAAKKKLEGDLKDLELQADSAIKGREEAIKQLRKLQAQMKDF 1657
Query: 119 SRKLE-------ERFMTLAANH--------ELMLRFKDEYKSENIKLREENEKLRLEN-- 161
R+LE E F T N +LM +D +E + + + EK L
Sbjct: 1658 QRELEDARASRDEIFATAKENEKKAKSLEADLMQLQEDLAAAERARKQADLEKEELAEEL 1717
Query: 162 -SSLFSQ-ALKDE----EAKVLQLTVRCEALTGELETLKERCAQDACQAQAREKELLELQ 215
SSL + AL+DE EA++ QL E G +E + +R + QA+ EL +
Sbjct: 1718 ASSLSGRNALQDEKRRLEARIAQLEEELEEEQGNMEAMSDRVRKATQQAEQLSNELATER 1777
Query: 216 SQQACTHT------KETEQLRSQLQ----TLKQQHQQAV----EQIAKAEETHSSLSQEL 261
S + ++ ++LRS+L +K + + + +IA+ EE ++E
Sbjct: 1778 STAQKNESARQQLERQNKELRSKLHEMEGAVKSKFKSTIAALEAKIAQLEEQVEQEAREK 1837
Query: 262 QARLQTVTRE----KEELLQLSIERGKVLQNKQAEICQLEEKLEIAN---EDRKHALERF 314
QA +++ ++ KE LLQ+ ER K AE Q +E+ E N + K LE
Sbjct: 1838 QAATKSLKQKDKKLKEILLQVEDER------KMAE--QYKEQAEKGNARVKQLKRQLEEA 1889
Query: 315 EQEAVAVDSNLRVRELQRKVDGIQKAYDELRLQSEAFK 352
E+E+ +++N R+LQR++D ++ + + + A K
Sbjct: 1890 EEESQRINANR--RKLQRELDEATESNEAMGREVNALK 1925
Score = 52.8 bits (125), Expect = 5e-07
Identities = 77/356 (21%), Positives = 148/356 (41%), Gaps = 27/356 (7%)
Query: 26 QNEKLNNQEEETEFKELDGLREALANLRGLSEEERSEKAMLRSRIEEQSQLICILKRRSD 85
+ ++ + E E K L R L E ER+ K ML++ +E+ + +
Sbjct: 1470 ERDRAEAEAREKETKALSLARALEEALEAKEELERTNK-MLKAEMEDLVSSKDDVGKNVH 1528
Query: 86 EALERCQILELLNAELEEKMMQEAEKLKAQGEYSRKLEERFMTLAANHELMLRFKDEYKS 145
E + + LE E++ ++ + ++L+A + +LE L E L+ +DE
Sbjct: 1529 ELEKSKRALETQMEEMKTQLEELEDELQATEDAKLRLEVNMQALKGQFERDLQARDEQNE 1588
Query: 146 ENIKLREENEKLRLENSSLFSQALKDEEAKVLQLTVRCEALTGELETLKERCAQDACQAQ 205
E K R+ +L + L+DE + + L G+L+ L+ + +
Sbjct: 1589 E--KRRQLQRQLH-----EYETELEDERKQRALAAAAKKKLEGDLKDLELQADSAIKGRE 1641
Query: 206 AREKELLELQSQQACTHTKETEQLRSQ----LQTLKQQHQQAVEQIAKAEETHSSLSQEL 261
K+L +LQ+Q +E E R+ T K+ ++A A + L+
Sbjct: 1642 EAIKQLRKLQAQMK-DFQRELEDARASRDEIFATAKENEKKAKSLEADLMQLQEDLAAAE 1700
Query: 262 QARLQTVTREKEEL---LQLSIERGKVLQNK----QAEICQLEEKLEIANEDRKHALERF 314
+AR Q EKEEL L S+ LQ++ +A I QLEE+LE + + +R
Sbjct: 1701 RARKQ-ADLEKEELAEELASSLSGRNALQDEKRRLEARIAQLEEELEEEQGNMEAMSDRV 1759
Query: 315 EQEAVAVDSNLRVRELQRKVDGIQKAYDELRLQSEAFKKHSLDLLSKERELNGKLR 370
+ + + +L ++ + + + ++ + +L SK E+ G ++
Sbjct: 1760 RK------ATQQAEQLSNELATERSTAQKNESARQQLERQNKELRSKLHEMEGAVK 1809
Score = 52.4 bits (124), Expect = 7e-07
Identities = 84/375 (22%), Positives = 153/375 (40%), Gaps = 75/375 (20%)
Query: 6 LQKQQAP-RMDTPPPEERLEKQNEKLNNQEEETEFKELDGLREALANLRGLSEEERSEKA 64
LQ Q A +M EE L+ +L+++ + L +RE ++ L E+ SE+A
Sbjct: 1074 LQAQIAELKMQLAKKEEELQAALARLDDEIAQKN-NALKKIRELEGHISDLQEDLDSERA 1132
Query: 65 MLRSRIEEQSQLICILKRRSDEALE--RCQILELLNA-----ELEEKMMQEAEKLK-AQG 116
R++ E+Q KR E LE + ++ + L++ EL K QE LK A
Sbjct: 1133 A-RNKAEKQ-------KRDLGEELEALKTELEDTLDSTATQQELRAKREQEVTVLKKALD 1184
Query: 117 EYSRKLEERFMTLAANH----ELMLRFKDEYKSENIKLREENEKLRLENSSLFSQALKDE 172
E +R E + + H E + +++K L + + L EN+ L
Sbjct: 1185 EETRSHEAQVQEMRQKHAQAVEELTEQLEQFKRAKANLDKNKQTLEKENADL-------- 1236
Query: 173 EAKVLQLTVRCEALTGELETLKERCAQDACQAQAREKELLELQSQQACTHTKETEQLRSQ 232
GEL L + A Q +K+ LE Q Q+ + + E+ R++
Sbjct: 1237 --------------AGELRVLGQ-----AKQEVEHKKKKLEAQVQELQSKCSDGERARAE 1277
Query: 233 LQTLKQQHQQAVEQIA-----------KAEETHSSLSQELQARLQTVTREKEELLQLSIE 281
L + Q VE + K + +SLS +LQ + + E + L +S +
Sbjct: 1278 LNDKVHKLQNEVESVTGMLNEAEGKAIKLAKDVASLSSQLQDTQELLQEETRQKLNVSTK 1337
Query: 282 RGKVLQNKQAEICQLEEKLE-------------IANEDRKHALERFEQEAVAVDSNLRVR 328
++ + + + QL+E++E I D K L+ F A++ +
Sbjct: 1338 LRQLEEERNSLQDQLDEEMEAKQNLERHISTLNIQLSDSKKKLQDFASTVEALEEG--KK 1395
Query: 329 ELQRKVDGIQKAYDE 343
Q++++ + + Y+E
Sbjct: 1396 RFQKEIENLTQQYEE 1410
Score = 48.1 bits (113), Expect = 1e-05
Identities = 72/309 (23%), Positives = 137/309 (44%), Gaps = 31/309 (10%)
Query: 6 LQKQQAPRMDTPPPEERLEKQNEKLNNQEEETEFKELDGLREALANLR-GLSEEERSEKA 64
L+K QA D E +++ +E E K+ L L L+ L+ ER+ K
Sbjct: 1647 LRKLQAQMKDFQRELEDARASRDEIFATAKENE-KKAKSLEADLMQLQEDLAAAERARKQ 1705
Query: 65 MLRSRIEEQSQLICILKRRSDEALERCQILELLNAELEEKMMQEAEKLKAQGEYSRKLEE 124
+ E +L L R+ E+ + LE A+LEE++ +E ++A + RK +
Sbjct: 1706 ADLEKEELAEELASSLSGRNALQDEKRR-LEARIAQLEEELEEEQGNMEAMSDRVRKATQ 1764
Query: 125 RFMTLAANHELMLRFKDEYKSENIK--LREENEKLR-----LENS--SLFSQALKDEEAK 175
+ L+ +EL K+E+ + L +N++LR +E + S F + EAK
Sbjct: 1765 QAEQLS--NELATERSTAQKNESARQQLERQNKELRSKLHEMEGAVKSKFKSTIAALEAK 1822
Query: 176 VLQLTVRCE-------ALTGELETLKERCAQDACQAQAREKELLELQSQQACTHTKETEQ 228
+ QL + E A T L+ ++ + Q + E+++ E +QA +Q
Sbjct: 1823 IAQLEEQVEQEAREKQAATKSLKQKDKKLKEILLQVED-ERKMAEQYKEQAEKGNARVKQ 1881
Query: 229 LRSQLQTLKQQHQ-------QAVEQIAKAEETHSSLSQELQARLQTVTREKEELLQLSIE 281
L+ QL+ +++ Q + ++ +A E++ ++ +E+ A + R E S
Sbjct: 1882 LKRQLEEAEEESQRINANRRKLQRELDEATESNEAMGREVNALKSKLRRGNETSFVPSRR 1941
Query: 282 RG--KVLQN 288
G +V++N
Sbjct: 1942 SGGRRVIEN 1950
Score = 47.0 bits (110), Expect = 3e-05
Identities = 44/168 (26%), Positives = 80/168 (47%), Gaps = 17/168 (10%)
Query: 209 KELLELQSQQACTHTKETEQLRSQLQTLKQQHQQAVEQIAKAEETHSSLSQE---LQARL 265
K LL++ Q+ KE E LQ K++ Q+A ++ + E+ HS L++E LQ +L
Sbjct: 842 KPLLQVTRQEEEMQAKEDE-----LQKTKERQQKAENELKELEQKHSQLTEEKNLLQEQL 896
Query: 266 QTVTREKEELLQLSIERGKVLQNKQAEICQLEEKLEIANEDRKHALE----RFEQEAVAV 321
Q T E ++ + Q + + ++E +LE EDR L+ + Q+ + +
Sbjct: 897 QAETELYAEAEEMRVRLAAKKQELEEILHEMEARLE-EEEDRGQQLQAERKKMAQQMLDL 955
Query: 322 DSNLRVRELQRKVDGIQKAYDELRLQSEAFKKHSLD----LLSKEREL 365
+ L E R+ ++K E +++ + +D LSKER+L
Sbjct: 956 EEQLEEEEAARQKLQLEKVTAEAKIKKLEDEILVMDDQNNKLSKERKL 1003
Score = 46.6 bits (109), Expect = 4e-05
Identities = 52/215 (24%), Positives = 99/215 (46%), Gaps = 25/215 (11%)
Query: 167 QALKDEEAKVLQLTVRCEALTGELETLKERCAQDACQAQAREKELLELQSQQACTHTKET 226
QA +DE K + + E EL+ L+++ +Q EK LL+ Q Q E
Sbjct: 855 QAKEDELQKTKERQQKAE---NELKELEQKHSQ-----LTEEKNLLQEQLQAETELYAEA 906
Query: 227 EQLRSQLQTLKQQHQQAVEQIAKAEETHSSLSQELQARLQTVTRE----KEELLQLSIER 282
E++R +L KQ+ ++ + ++ E Q+LQA + + ++ +E+L + R
Sbjct: 907 EEMRVRLAAKKQELEEILHEMEARLEEEEDRGQQLQAERKKMAQQMLDLEEQLEEEEAAR 966
Query: 283 GKVLQNK---QAEICQLEEK-LEIANEDRKHALERFEQEAVAVDSNLRVRELQRKVDGIQ 338
K+ K +A+I +LE++ L + +++ K + ER E D + E + K +
Sbjct: 967 QKLQLEKVTAEAKIKKLEDEILVMDDQNNKLSKERKLLEERISDLTTNLAEEEEKAKNLT 1026
Query: 339 KAYD---------ELRLQSEAFKKHSLDLLSKERE 364
K + E+RL+ E + L+ L ++ E
Sbjct: 1027 KLKNKHESMISELEVRLKKEEKSRQELEKLKRKLE 1061
>gi|92091586 smooth muscle myosin heavy chain 11 isoform SM1B [Homo
sapiens]
Length = 1979
Score = 72.0 bits (175), Expect = 8e-13
Identities = 86/359 (23%), Positives = 152/359 (42%), Gaps = 40/359 (11%)
Query: 6 LQKQQAPRMDTPPPEERLEKQNEKLNNQEEETEFKELDGLREALANLRGLSEEERSEKAM 65
L++++A R +LEK + ++ E E +D L+ R L EE S+
Sbjct: 966 LEEEEAARQKL-----QLEKVTAEAKIKKLEDEILVMDDQNNKLSKERKLLEERISDLTT 1020
Query: 66 LRSRIEEQSQLICILKRRSDEALERCQILELLNAELEEKMMQEAEKLKAQ---------- 115
+ EE+++ + LK + + + ++ + EEK QE EKLK +
Sbjct: 1021 NLAEEEEKAKNLTKLKNKHESMISELEV----RLKKEEKSRQELEKLKRKLEGDASDFHE 1076
Query: 116 --GEYSRKLEERFMTLAANHE----LMLRFKDEYKSENIKLREENEKLRLENS-SLFSQA 168
+ ++ E M LA E + R DE +N L++ E LE S +
Sbjct: 1077 QIADLQAQIAELKMQLAKKEEELQAALARLDDEIAQKNNALKKIRE---LEGHISDLQED 1133
Query: 169 LKDEEAKVLQLTVRCEALTGELETLKERCAQDACQAQAREKELLELQSQQACTHTK---- 224
L E A + + L ELE LK +D + A ++EL + Q+ K
Sbjct: 1134 LDSERAARNKAEKQKRDLGEELEALKTEL-EDTLDSTATQQELRAKREQEVTVLKKALDE 1192
Query: 225 ETEQLRSQLQTLKQQHQQAVEQIAKAEETHSSLSQELQARLQTVTREKEELLQLSIERGK 284
ET +Q+Q ++Q+H QAVE++ + E L QT+ +E +L +
Sbjct: 1193 ETRSHEAQVQEMRQKHAQAVEELTEQLEQFKRAKANLDKNKQTLEKENADL----AGELR 1248
Query: 285 VLQNKQAEICQLEEKLEIANEDRKHALERFEQEAVAVDSNLRVRELQRKVDGIQKAYDE 343
VL + E+ ++KLE ++ + + E + N +V +LQ +V+ + +E
Sbjct: 1249 VLGQAKQEVEHKKKKLEAQVQELQSKCS--DGERARAELNDKVHKLQNEVESVTGMLNE 1305
Score = 63.2 bits (152), Expect = 4e-10
Identities = 92/409 (22%), Positives = 179/409 (43%), Gaps = 47/409 (11%)
Query: 6 LQKQQAPRMDTPPPEERLEKQNEKLNNQEEET-----EFKELDGLREALANL--RGLSEE 58
L ++A R + L ++ E L + E+T +EL RE + + L EE
Sbjct: 1134 LDSERAARNKAEKQKRDLGEELEALKTELEDTLDSTATQQELRAKREQEVTVLKKALDEE 1193
Query: 59 ERSEKAMLRSRIEEQSQLICILKRRSDEALERCQILELLNAELEEKMMQEAEKLKAQGEY 118
RS +A ++ ++ +Q + L + ++ L+ LE++ A +L+ G+
Sbjct: 1194 TRSHEAQVQEMRQKHAQAVEELTEQLEQFKRAKANLDKNKQTLEKENADLAGELRVLGQA 1253
Query: 119 SRKLEERFMTLAAN-HELMLRFKD------EYKSENIKLREENE--------------KL 157
+++E + L A EL + D E + KL+ E E KL
Sbjct: 1254 KQEVEHKKKKLEAQVQELQSKCSDGERARAELNDKVHKLQNEVESVTGMLNEAEGKAIKL 1313
Query: 158 RLENSSLFSQA------LKDEEAKVLQLTVRCEALTGELETLKERCAQDACQAQAREKEL 211
+ +SL SQ L++E + L ++ + L E +L+++ ++ Q E+ +
Sbjct: 1314 AKDVASLSSQLQDTQELLQEETRQKLNVSTKLRQLEEERNSLQDQLDEEMEAKQNLERHI 1373
Query: 212 LELQSQQACTHTKETEQLRSQLQTL---KQQHQQAVEQIAKAEETHSSLSQELQARLQTV 268
L Q + + K+ + S ++ L K++ Q+ +E + + E ++ +L+ +
Sbjct: 1374 STLNIQLSDSK-KKLQDFASTVEALEEGKKRFQKEIENLTQQYEEKAAAYDKLEKTKNRL 1432
Query: 269 TREKEELL-QLSIERGKV--LQNKQAEICQL--EEKLEIANEDRKHALERFEQEAVAVDS 323
+E ++L+ L +R V L+ KQ + QL EEK N K+A ER EA A +
Sbjct: 1433 QQELDDLVVDLDNQRQLVSNLEKKQRKFDQLLAEEK----NISSKYADERDRAEAEAREK 1488
Query: 324 NLRVRELQRKVDGIQKAYDELRLQSEAFKKHSLDLLSKERELNGKLRHL 372
+ L R ++ +A +EL ++ K DL+S + ++ + L
Sbjct: 1489 ETKALSLARALEEALEAKEELERTNKMLKAEMEDLVSSKDDVGKNVHEL 1537
Score = 59.3 bits (142), Expect = 5e-09
Identities = 96/398 (24%), Positives = 178/398 (44%), Gaps = 75/398 (18%)
Query: 20 EERLEKQNEKLNNQEEETEFKELDGLR-----EALA-----NLRGLSEEERSEKAMLRSR 69
E ++E+ +L E+E + E LR +AL +L+ E+ ++ L+ +
Sbjct: 1545 ETQMEEMKTQLEELEDELQATEDAKLRLEVNMQALKGQFERDLQARDEQNEEKRRQLQRQ 1604
Query: 70 IEE----------QSQLICILKRRSDEALERCQILELLNAELEEKMMQEAEKLKAQ-GEY 118
+ E Q L K++ + L+ ++ + E+ +++ KL+AQ ++
Sbjct: 1605 LHEYETELEDERKQRALAAAAKKKLEGDLKDLELQADSAIKGREEAIKQLRKLQAQMKDF 1664
Query: 119 SRKLE-------ERFMTLAANH--------ELMLRFKDEYKSENIKLREENEKLRLEN-- 161
R+LE E F T N +LM +D +E + + + EK L
Sbjct: 1665 QRELEDARASRDEIFATAKENEKKAKSLEADLMQLQEDLAAAERARKQADLEKEELAEEL 1724
Query: 162 -SSLFSQ-ALKDE----EAKVLQLTVRCEALTGELETLKERCAQDACQAQAREKELLELQ 215
SSL + AL+DE EA++ QL E G +E + +R + QA+ EL +
Sbjct: 1725 ASSLSGRNALQDEKRRLEARIAQLEEELEEEQGNMEAMSDRVRKATQQAEQLSNELATER 1784
Query: 216 SQQACTHT------KETEQLRSQLQ----TLKQQHQQAV----EQIAKAEETHSSLSQEL 261
S + ++ ++LRS+L +K + + + +IA+ EE ++E
Sbjct: 1785 STAQKNESARQQLERQNKELRSKLHEMEGAVKSKFKSTIAALEAKIAQLEEQVEQEAREK 1844
Query: 262 QARLQTVTRE----KEELLQLSIERGKVLQNKQAEICQLEEKLEIAN---EDRKHALERF 314
QA +++ ++ KE LLQ+ ER K AE Q +E+ E N + K LE
Sbjct: 1845 QAATKSLKQKDKKLKEILLQVEDER------KMAE--QYKEQAEKGNARVKQLKRQLEEA 1896
Query: 315 EQEAVAVDSNLRVRELQRKVDGIQKAYDELRLQSEAFK 352
E+E+ +++N R+LQR++D ++ + + + A K
Sbjct: 1897 EEESQRINANR--RKLQRELDEATESNEAMGREVNALK 1932
Score = 52.8 bits (125), Expect = 5e-07
Identities = 77/356 (21%), Positives = 148/356 (41%), Gaps = 27/356 (7%)
Query: 26 QNEKLNNQEEETEFKELDGLREALANLRGLSEEERSEKAMLRSRIEEQSQLICILKRRSD 85
+ ++ + E E K L R L E ER+ K ML++ +E+ + +
Sbjct: 1477 ERDRAEAEAREKETKALSLARALEEALEAKEELERTNK-MLKAEMEDLVSSKDDVGKNVH 1535
Query: 86 EALERCQILELLNAELEEKMMQEAEKLKAQGEYSRKLEERFMTLAANHELMLRFKDEYKS 145
E + + LE E++ ++ + ++L+A + +LE L E L+ +DE
Sbjct: 1536 ELEKSKRALETQMEEMKTQLEELEDELQATEDAKLRLEVNMQALKGQFERDLQARDEQNE 1595
Query: 146 ENIKLREENEKLRLENSSLFSQALKDEEAKVLQLTVRCEALTGELETLKERCAQDACQAQ 205
E K R+ +L + L+DE + + L G+L+ L+ + +
Sbjct: 1596 E--KRRQLQRQLH-----EYETELEDERKQRALAAAAKKKLEGDLKDLELQADSAIKGRE 1648
Query: 206 AREKELLELQSQQACTHTKETEQLRSQ----LQTLKQQHQQAVEQIAKAEETHSSLSQEL 261
K+L +LQ+Q +E E R+ T K+ ++A A + L+
Sbjct: 1649 EAIKQLRKLQAQMK-DFQRELEDARASRDEIFATAKENEKKAKSLEADLMQLQEDLAAAE 1707
Query: 262 QARLQTVTREKEEL---LQLSIERGKVLQNK----QAEICQLEEKLEIANEDRKHALERF 314
+AR Q EKEEL L S+ LQ++ +A I QLEE+LE + + +R
Sbjct: 1708 RARKQ-ADLEKEELAEELASSLSGRNALQDEKRRLEARIAQLEEELEEEQGNMEAMSDRV 1766
Query: 315 EQEAVAVDSNLRVRELQRKVDGIQKAYDELRLQSEAFKKHSLDLLSKERELNGKLR 370
+ + + +L ++ + + + ++ + +L SK E+ G ++
Sbjct: 1767 RK------ATQQAEQLSNELATERSTAQKNESARQQLERQNKELRSKLHEMEGAVK 1816
Score = 52.4 bits (124), Expect = 7e-07
Identities = 84/375 (22%), Positives = 153/375 (40%), Gaps = 75/375 (20%)
Query: 6 LQKQQAP-RMDTPPPEERLEKQNEKLNNQEEETEFKELDGLREALANLRGLSEEERSEKA 64
LQ Q A +M EE L+ +L+++ + L +RE ++ L E+ SE+A
Sbjct: 1081 LQAQIAELKMQLAKKEEELQAALARLDDEIAQKN-NALKKIRELEGHISDLQEDLDSERA 1139
Query: 65 MLRSRIEEQSQLICILKRRSDEALE--RCQILELLNA-----ELEEKMMQEAEKLK-AQG 116
R++ E+Q KR E LE + ++ + L++ EL K QE LK A
Sbjct: 1140 A-RNKAEKQ-------KRDLGEELEALKTELEDTLDSTATQQELRAKREQEVTVLKKALD 1191
Query: 117 EYSRKLEERFMTLAANH----ELMLRFKDEYKSENIKLREENEKLRLENSSLFSQALKDE 172
E +R E + + H E + +++K L + + L EN+ L
Sbjct: 1192 EETRSHEAQVQEMRQKHAQAVEELTEQLEQFKRAKANLDKNKQTLEKENADL-------- 1243
Query: 173 EAKVLQLTVRCEALTGELETLKERCAQDACQAQAREKELLELQSQQACTHTKETEQLRSQ 232
GEL L + A Q +K+ LE Q Q+ + + E+ R++
Sbjct: 1244 --------------AGELRVLGQ-----AKQEVEHKKKKLEAQVQELQSKCSDGERARAE 1284
Query: 233 LQTLKQQHQQAVEQIA-----------KAEETHSSLSQELQARLQTVTREKEELLQLSIE 281
L + Q VE + K + +SLS +LQ + + E + L +S +
Sbjct: 1285 LNDKVHKLQNEVESVTGMLNEAEGKAIKLAKDVASLSSQLQDTQELLQEETRQKLNVSTK 1344
Query: 282 RGKVLQNKQAEICQLEEKLE-------------IANEDRKHALERFEQEAVAVDSNLRVR 328
++ + + + QL+E++E I D K L+ F A++ +
Sbjct: 1345 LRQLEEERNSLQDQLDEEMEAKQNLERHISTLNIQLSDSKKKLQDFASTVEALEEG--KK 1402
Query: 329 ELQRKVDGIQKAYDE 343
Q++++ + + Y+E
Sbjct: 1403 RFQKEIENLTQQYEE 1417
Score = 48.1 bits (113), Expect = 1e-05
Identities = 72/309 (23%), Positives = 137/309 (44%), Gaps = 31/309 (10%)
Query: 6 LQKQQAPRMDTPPPEERLEKQNEKLNNQEEETEFKELDGLREALANLR-GLSEEERSEKA 64
L+K QA D E +++ +E E K+ L L L+ L+ ER+ K
Sbjct: 1654 LRKLQAQMKDFQRELEDARASRDEIFATAKENE-KKAKSLEADLMQLQEDLAAAERARKQ 1712
Query: 65 MLRSRIEEQSQLICILKRRSDEALERCQILELLNAELEEKMMQEAEKLKAQGEYSRKLEE 124
+ E +L L R+ E+ + LE A+LEE++ +E ++A + RK +
Sbjct: 1713 ADLEKEELAEELASSLSGRNALQDEKRR-LEARIAQLEEELEEEQGNMEAMSDRVRKATQ 1771
Query: 125 RFMTLAANHELMLRFKDEYKSENIK--LREENEKLR-----LENS--SLFSQALKDEEAK 175
+ L+ +EL K+E+ + L +N++LR +E + S F + EAK
Sbjct: 1772 QAEQLS--NELATERSTAQKNESARQQLERQNKELRSKLHEMEGAVKSKFKSTIAALEAK 1829
Query: 176 VLQLTVRCE-------ALTGELETLKERCAQDACQAQAREKELLELQSQQACTHTKETEQ 228
+ QL + E A T L+ ++ + Q + E+++ E +QA +Q
Sbjct: 1830 IAQLEEQVEQEAREKQAATKSLKQKDKKLKEILLQVED-ERKMAEQYKEQAEKGNARVKQ 1888
Query: 229 LRSQLQTLKQQHQ-------QAVEQIAKAEETHSSLSQELQARLQTVTREKEELLQLSIE 281
L+ QL+ +++ Q + ++ +A E++ ++ +E+ A + R E S
Sbjct: 1889 LKRQLEEAEEESQRINANRRKLQRELDEATESNEAMGREVNALKSKLRRGNETSFVPSRR 1948
Query: 282 RG--KVLQN 288
G +V++N
Sbjct: 1949 SGGRRVIEN 1957
Score = 47.0 bits (110), Expect = 3e-05
Identities = 44/168 (26%), Positives = 80/168 (47%), Gaps = 17/168 (10%)
Query: 209 KELLELQSQQACTHTKETEQLRSQLQTLKQQHQQAVEQIAKAEETHSSLSQE---LQARL 265
K LL++ Q+ KE E LQ K++ Q+A ++ + E+ HS L++E LQ +L
Sbjct: 849 KPLLQVTRQEEEMQAKEDE-----LQKTKERQQKAENELKELEQKHSQLTEEKNLLQEQL 903
Query: 266 QTVTREKEELLQLSIERGKVLQNKQAEICQLEEKLEIANEDRKHALE----RFEQEAVAV 321
Q T E ++ + Q + + ++E +LE EDR L+ + Q+ + +
Sbjct: 904 QAETELYAEAEEMRVRLAAKKQELEEILHEMEARLE-EEEDRGQQLQAERKKMAQQMLDL 962
Query: 322 DSNLRVRELQRKVDGIQKAYDELRLQSEAFKKHSLD----LLSKEREL 365
+ L E R+ ++K E +++ + +D LSKER+L
Sbjct: 963 EEQLEEEEAARQKLQLEKVTAEAKIKKLEDEILVMDDQNNKLSKERKL 1010
Score = 46.6 bits (109), Expect = 4e-05
Identities = 52/215 (24%), Positives = 99/215 (46%), Gaps = 25/215 (11%)
Query: 167 QALKDEEAKVLQLTVRCEALTGELETLKERCAQDACQAQAREKELLELQSQQACTHTKET 226
QA +DE K + + E EL+ L+++ +Q EK LL+ Q Q E
Sbjct: 862 QAKEDELQKTKERQQKAE---NELKELEQKHSQ-----LTEEKNLLQEQLQAETELYAEA 913
Query: 227 EQLRSQLQTLKQQHQQAVEQIAKAEETHSSLSQELQARLQTVTRE----KEELLQLSIER 282
E++R +L KQ+ ++ + ++ E Q+LQA + + ++ +E+L + R
Sbjct: 914 EEMRVRLAAKKQELEEILHEMEARLEEEEDRGQQLQAERKKMAQQMLDLEEQLEEEEAAR 973
Query: 283 GKVLQNK---QAEICQLEEK-LEIANEDRKHALERFEQEAVAVDSNLRVRELQRKVDGIQ 338
K+ K +A+I +LE++ L + +++ K + ER E D + E + K +
Sbjct: 974 QKLQLEKVTAEAKIKKLEDEILVMDDQNNKLSKERKLLEERISDLTTNLAEEEEKAKNLT 1033
Query: 339 KAYD---------ELRLQSEAFKKHSLDLLSKERE 364
K + E+RL+ E + L+ L ++ E
Sbjct: 1034 KLKNKHESMISELEVRLKKEEKSRQELEKLKRKLE 1068
>gi|92091583 smooth muscle myosin heavy chain 11 isoform SM2B [Homo
sapiens]
Length = 1945
Score = 72.0 bits (175), Expect = 8e-13
Identities = 86/359 (23%), Positives = 152/359 (42%), Gaps = 40/359 (11%)
Query: 6 LQKQQAPRMDTPPPEERLEKQNEKLNNQEEETEFKELDGLREALANLRGLSEEERSEKAM 65
L++++A R +LEK + ++ E E +D L+ R L EE S+
Sbjct: 966 LEEEEAARQKL-----QLEKVTAEAKIKKLEDEILVMDDQNNKLSKERKLLEERISDLTT 1020
Query: 66 LRSRIEEQSQLICILKRRSDEALERCQILELLNAELEEKMMQEAEKLKAQ---------- 115
+ EE+++ + LK + + + ++ + EEK QE EKLK +
Sbjct: 1021 NLAEEEEKAKNLTKLKNKHESMISELEV----RLKKEEKSRQELEKLKRKLEGDASDFHE 1076
Query: 116 --GEYSRKLEERFMTLAANHE----LMLRFKDEYKSENIKLREENEKLRLENS-SLFSQA 168
+ ++ E M LA E + R DE +N L++ E LE S +
Sbjct: 1077 QIADLQAQIAELKMQLAKKEEELQAALARLDDEIAQKNNALKKIRE---LEGHISDLQED 1133
Query: 169 LKDEEAKVLQLTVRCEALTGELETLKERCAQDACQAQAREKELLELQSQQACTHTK---- 224
L E A + + L ELE LK +D + A ++EL + Q+ K
Sbjct: 1134 LDSERAARNKAEKQKRDLGEELEALKTEL-EDTLDSTATQQELRAKREQEVTVLKKALDE 1192
Query: 225 ETEQLRSQLQTLKQQHQQAVEQIAKAEETHSSLSQELQARLQTVTREKEELLQLSIERGK 284
ET +Q+Q ++Q+H QAVE++ + E L QT+ +E +L +
Sbjct: 1193 ETRSHEAQVQEMRQKHAQAVEELTEQLEQFKRAKANLDKNKQTLEKENADL----AGELR 1248
Query: 285 VLQNKQAEICQLEEKLEIANEDRKHALERFEQEAVAVDSNLRVRELQRKVDGIQKAYDE 343
VL + E+ ++KLE ++ + + E + N +V +LQ +V+ + +E
Sbjct: 1249 VLGQAKQEVEHKKKKLEAQVQELQSKCS--DGERARAELNDKVHKLQNEVESVTGMLNE 1305
Score = 63.2 bits (152), Expect = 4e-10
Identities = 92/409 (22%), Positives = 179/409 (43%), Gaps = 47/409 (11%)
Query: 6 LQKQQAPRMDTPPPEERLEKQNEKLNNQEEET-----EFKELDGLREALANL--RGLSEE 58
L ++A R + L ++ E L + E+T +EL RE + + L EE
Sbjct: 1134 LDSERAARNKAEKQKRDLGEELEALKTELEDTLDSTATQQELRAKREQEVTVLKKALDEE 1193
Query: 59 ERSEKAMLRSRIEEQSQLICILKRRSDEALERCQILELLNAELEEKMMQEAEKLKAQGEY 118
RS +A ++ ++ +Q + L + ++ L+ LE++ A +L+ G+
Sbjct: 1194 TRSHEAQVQEMRQKHAQAVEELTEQLEQFKRAKANLDKNKQTLEKENADLAGELRVLGQA 1253
Query: 119 SRKLEERFMTLAAN-HELMLRFKD------EYKSENIKLREENE--------------KL 157
+++E + L A EL + D E + KL+ E E KL
Sbjct: 1254 KQEVEHKKKKLEAQVQELQSKCSDGERARAELNDKVHKLQNEVESVTGMLNEAEGKAIKL 1313
Query: 158 RLENSSLFSQA------LKDEEAKVLQLTVRCEALTGELETLKERCAQDACQAQAREKEL 211
+ +SL SQ L++E + L ++ + L E +L+++ ++ Q E+ +
Sbjct: 1314 AKDVASLSSQLQDTQELLQEETRQKLNVSTKLRQLEEERNSLQDQLDEEMEAKQNLERHI 1373
Query: 212 LELQSQQACTHTKETEQLRSQLQTL---KQQHQQAVEQIAKAEETHSSLSQELQARLQTV 268
L Q + + K+ + S ++ L K++ Q+ +E + + E ++ +L+ +
Sbjct: 1374 STLNIQLSDSK-KKLQDFASTVEALEEGKKRFQKEIENLTQQYEEKAAAYDKLEKTKNRL 1432
Query: 269 TREKEELL-QLSIERGKV--LQNKQAEICQL--EEKLEIANEDRKHALERFEQEAVAVDS 323
+E ++L+ L +R V L+ KQ + QL EEK N K+A ER EA A +
Sbjct: 1433 QQELDDLVVDLDNQRQLVSNLEKKQRKFDQLLAEEK----NISSKYADERDRAEAEAREK 1488
Query: 324 NLRVRELQRKVDGIQKAYDELRLQSEAFKKHSLDLLSKERELNGKLRHL 372
+ L R ++ +A +EL ++ K DL+S + ++ + L
Sbjct: 1489 ETKALSLARALEEALEAKEELERTNKMLKAEMEDLVSSKDDVGKNVHEL 1537
Score = 59.3 bits (142), Expect = 5e-09
Identities = 96/398 (24%), Positives = 178/398 (44%), Gaps = 75/398 (18%)
Query: 20 EERLEKQNEKLNNQEEETEFKELDGLR-----EALA-----NLRGLSEEERSEKAMLRSR 69
E ++E+ +L E+E + E LR +AL +L+ E+ ++ L+ +
Sbjct: 1545 ETQMEEMKTQLEELEDELQATEDAKLRLEVNMQALKGQFERDLQARDEQNEEKRRQLQRQ 1604
Query: 70 IEE----------QSQLICILKRRSDEALERCQILELLNAELEEKMMQEAEKLKAQ-GEY 118
+ E Q L K++ + L+ ++ + E+ +++ KL+AQ ++
Sbjct: 1605 LHEYETELEDERKQRALAAAAKKKLEGDLKDLELQADSAIKGREEAIKQLRKLQAQMKDF 1664
Query: 119 SRKLE-------ERFMTLAANH--------ELMLRFKDEYKSENIKLREENEKLRLEN-- 161
R+LE E F T N +LM +D +E + + + EK L
Sbjct: 1665 QRELEDARASRDEIFATAKENEKKAKSLEADLMQLQEDLAAAERARKQADLEKEELAEEL 1724
Query: 162 -SSLFSQ-ALKDE----EAKVLQLTVRCEALTGELETLKERCAQDACQAQAREKELLELQ 215
SSL + AL+DE EA++ QL E G +E + +R + QA+ EL +
Sbjct: 1725 ASSLSGRNALQDEKRRLEARIAQLEEELEEEQGNMEAMSDRVRKATQQAEQLSNELATER 1784
Query: 216 SQQACTHT------KETEQLRSQLQ----TLKQQHQQAV----EQIAKAEETHSSLSQEL 261
S + ++ ++LRS+L +K + + + +IA+ EE ++E
Sbjct: 1785 STAQKNESARQQLERQNKELRSKLHEMEGAVKSKFKSTIAALEAKIAQLEEQVEQEAREK 1844
Query: 262 QARLQTVTRE----KEELLQLSIERGKVLQNKQAEICQLEEKLEIAN---EDRKHALERF 314
QA +++ ++ KE LLQ+ ER K AE Q +E+ E N + K LE
Sbjct: 1845 QAATKSLKQKDKKLKEILLQVEDER------KMAE--QYKEQAEKGNARVKQLKRQLEEA 1896
Query: 315 EQEAVAVDSNLRVRELQRKVDGIQKAYDELRLQSEAFK 352
E+E+ +++N R+LQR++D ++ + + + A K
Sbjct: 1897 EEESQRINANR--RKLQRELDEATESNEAMGREVNALK 1932
Score = 52.8 bits (125), Expect = 5e-07
Identities = 77/356 (21%), Positives = 148/356 (41%), Gaps = 27/356 (7%)
Query: 26 QNEKLNNQEEETEFKELDGLREALANLRGLSEEERSEKAMLRSRIEEQSQLICILKRRSD 85
+ ++ + E E K L R L E ER+ K ML++ +E+ + +
Sbjct: 1477 ERDRAEAEAREKETKALSLARALEEALEAKEELERTNK-MLKAEMEDLVSSKDDVGKNVH 1535
Query: 86 EALERCQILELLNAELEEKMMQEAEKLKAQGEYSRKLEERFMTLAANHELMLRFKDEYKS 145
E + + LE E++ ++ + ++L+A + +LE L E L+ +DE
Sbjct: 1536 ELEKSKRALETQMEEMKTQLEELEDELQATEDAKLRLEVNMQALKGQFERDLQARDEQNE 1595
Query: 146 ENIKLREENEKLRLENSSLFSQALKDEEAKVLQLTVRCEALTGELETLKERCAQDACQAQ 205
E K R+ +L + L+DE + + L G+L+ L+ + +
Sbjct: 1596 E--KRRQLQRQLH-----EYETELEDERKQRALAAAAKKKLEGDLKDLELQADSAIKGRE 1648
Query: 206 AREKELLELQSQQACTHTKETEQLRSQ----LQTLKQQHQQAVEQIAKAEETHSSLSQEL 261
K+L +LQ+Q +E E R+ T K+ ++A A + L+
Sbjct: 1649 EAIKQLRKLQAQMK-DFQRELEDARASRDEIFATAKENEKKAKSLEADLMQLQEDLAAAE 1707
Query: 262 QARLQTVTREKEEL---LQLSIERGKVLQNK----QAEICQLEEKLEIANEDRKHALERF 314
+AR Q EKEEL L S+ LQ++ +A I QLEE+LE + + +R
Sbjct: 1708 RARKQ-ADLEKEELAEELASSLSGRNALQDEKRRLEARIAQLEEELEEEQGNMEAMSDRV 1766
Query: 315 EQEAVAVDSNLRVRELQRKVDGIQKAYDELRLQSEAFKKHSLDLLSKERELNGKLR 370
+ + + +L ++ + + + ++ + +L SK E+ G ++
Sbjct: 1767 RK------ATQQAEQLSNELATERSTAQKNESARQQLERQNKELRSKLHEMEGAVK 1816
Score = 52.4 bits (124), Expect = 7e-07
Identities = 84/375 (22%), Positives = 153/375 (40%), Gaps = 75/375 (20%)
Query: 6 LQKQQAP-RMDTPPPEERLEKQNEKLNNQEEETEFKELDGLREALANLRGLSEEERSEKA 64
LQ Q A +M EE L+ +L+++ + L +RE ++ L E+ SE+A
Sbjct: 1081 LQAQIAELKMQLAKKEEELQAALARLDDEIAQKN-NALKKIRELEGHISDLQEDLDSERA 1139
Query: 65 MLRSRIEEQSQLICILKRRSDEALE--RCQILELLNA-----ELEEKMMQEAEKLK-AQG 116
R++ E+Q KR E LE + ++ + L++ EL K QE LK A
Sbjct: 1140 A-RNKAEKQ-------KRDLGEELEALKTELEDTLDSTATQQELRAKREQEVTVLKKALD 1191
Query: 117 EYSRKLEERFMTLAANH----ELMLRFKDEYKSENIKLREENEKLRLENSSLFSQALKDE 172
E +R E + + H E + +++K L + + L EN+ L
Sbjct: 1192 EETRSHEAQVQEMRQKHAQAVEELTEQLEQFKRAKANLDKNKQTLEKENADL-------- 1243
Query: 173 EAKVLQLTVRCEALTGELETLKERCAQDACQAQAREKELLELQSQQACTHTKETEQLRSQ 232
GEL L + A Q +K+ LE Q Q+ + + E+ R++
Sbjct: 1244 --------------AGELRVLGQ-----AKQEVEHKKKKLEAQVQELQSKCSDGERARAE 1284
Query: 233 LQTLKQQHQQAVEQIA-----------KAEETHSSLSQELQARLQTVTREKEELLQLSIE 281
L + Q VE + K + +SLS +LQ + + E + L +S +
Sbjct: 1285 LNDKVHKLQNEVESVTGMLNEAEGKAIKLAKDVASLSSQLQDTQELLQEETRQKLNVSTK 1344
Query: 282 RGKVLQNKQAEICQLEEKLE-------------IANEDRKHALERFEQEAVAVDSNLRVR 328
++ + + + QL+E++E I D K L+ F A++ +
Sbjct: 1345 LRQLEEERNSLQDQLDEEMEAKQNLERHISTLNIQLSDSKKKLQDFASTVEALEEG--KK 1402
Query: 329 ELQRKVDGIQKAYDE 343
Q++++ + + Y+E
Sbjct: 1403 RFQKEIENLTQQYEE 1417
Score = 47.0 bits (110), Expect = 3e-05
Identities = 44/168 (26%), Positives = 80/168 (47%), Gaps = 17/168 (10%)
Query: 209 KELLELQSQQACTHTKETEQLRSQLQTLKQQHQQAVEQIAKAEETHSSLSQE---LQARL 265
K LL++ Q+ KE E LQ K++ Q+A ++ + E+ HS L++E LQ +L
Sbjct: 849 KPLLQVTRQEEEMQAKEDE-----LQKTKERQQKAENELKELEQKHSQLTEEKNLLQEQL 903
Query: 266 QTVTREKEELLQLSIERGKVLQNKQAEICQLEEKLEIANEDRKHALE----RFEQEAVAV 321
Q T E ++ + Q + + ++E +LE EDR L+ + Q+ + +
Sbjct: 904 QAETELYAEAEEMRVRLAAKKQELEEILHEMEARLE-EEEDRGQQLQAERKKMAQQMLDL 962
Query: 322 DSNLRVRELQRKVDGIQKAYDELRLQSEAFKKHSLD----LLSKEREL 365
+ L E R+ ++K E +++ + +D LSKER+L
Sbjct: 963 EEQLEEEEAARQKLQLEKVTAEAKIKKLEDEILVMDDQNNKLSKERKL 1010
Score = 46.6 bits (109), Expect = 4e-05
Identities = 52/215 (24%), Positives = 99/215 (46%), Gaps = 25/215 (11%)
Query: 167 QALKDEEAKVLQLTVRCEALTGELETLKERCAQDACQAQAREKELLELQSQQACTHTKET 226
QA +DE K + + E EL+ L+++ +Q EK LL+ Q Q E
Sbjct: 862 QAKEDELQKTKERQQKAE---NELKELEQKHSQ-----LTEEKNLLQEQLQAETELYAEA 913
Query: 227 EQLRSQLQTLKQQHQQAVEQIAKAEETHSSLSQELQARLQTVTRE----KEELLQLSIER 282
E++R +L KQ+ ++ + ++ E Q+LQA + + ++ +E+L + R
Sbjct: 914 EEMRVRLAAKKQELEEILHEMEARLEEEEDRGQQLQAERKKMAQQMLDLEEQLEEEEAAR 973
Query: 283 GKVLQNK---QAEICQLEEK-LEIANEDRKHALERFEQEAVAVDSNLRVRELQRKVDGIQ 338
K+ K +A+I +LE++ L + +++ K + ER E D + E + K +
Sbjct: 974 QKLQLEKVTAEAKIKKLEDEILVMDDQNNKLSKERKLLEERISDLTTNLAEEEEKAKNLT 1033
Query: 339 KAYD---------ELRLQSEAFKKHSLDLLSKERE 364
K + E+RL+ E + L+ L ++ E
Sbjct: 1034 KLKNKHESMISELEVRLKKEEKSRQELEKLKRKLE 1068
Score = 46.6 bits (109), Expect = 4e-05
Identities = 66/282 (23%), Positives = 127/282 (45%), Gaps = 29/282 (10%)
Query: 6 LQKQQAPRMDTPPPEERLEKQNEKLNNQEEETEFKELDGLREALANLR-GLSEEERSEKA 64
L+K QA D E +++ +E E K+ L L L+ L+ ER+ K
Sbjct: 1654 LRKLQAQMKDFQRELEDARASRDEIFATAKENE-KKAKSLEADLMQLQEDLAAAERARKQ 1712
Query: 65 MLRSRIEEQSQLICILKRRSDEALERCQILELLNAELEEKMMQEAEKLKAQGEYSRKLEE 124
+ E +L L R+ E+ + LE A+LEE++ +E ++A + RK +
Sbjct: 1713 ADLEKEELAEELASSLSGRNALQDEKRR-LEARIAQLEEELEEEQGNMEAMSDRVRKATQ 1771
Query: 125 RFMTLAANHELMLRFKDEYKSENIK--LREENEKLR-----LENS--SLFSQALKDEEAK 175
+ L+ +EL K+E+ + L +N++LR +E + S F + EAK
Sbjct: 1772 QAEQLS--NELATERSTAQKNESARQQLERQNKELRSKLHEMEGAVKSKFKSTIAALEAK 1829
Query: 176 VLQLTVRCE-------ALTGELETLKERCAQDACQAQAREKELLELQSQQACTHTKETEQ 228
+ QL + E A T L+ ++ + Q + E+++ E +QA +Q
Sbjct: 1830 IAQLEEQVEQEAREKQAATKSLKQKDKKLKEILLQVED-ERKMAEQYKEQAEKGNARVKQ 1888
Query: 229 LRSQLQTLKQQHQ-------QAVEQIAKAEETHSSLSQELQA 263
L+ QL+ +++ Q + ++ +A E++ ++ +E+ A
Sbjct: 1889 LKRQLEEAEEESQRINANRRKLQRELDEATESNEAMGREVNA 1930
Score = 30.8 bits (68), Expect = 2.1
Identities = 24/104 (23%), Positives = 49/104 (47%), Gaps = 1/104 (0%)
Query: 22 RLEKQNEKLNNQEEETEFKELDGLREALANLRGLSEEERSEKAMLRSRIEEQSQLICILK 81
+LE+Q E+ +E++ K L + L + E+ER + + E+ + + LK
Sbjct: 1832 QLEEQVEQ-EAREKQAATKSLKQKDKKLKEILLQVEDERKMAEQYKEQAEKGNARVKQLK 1890
Query: 82 RRSDEALERCQILELLNAELEEKMMQEAEKLKAQGEYSRKLEER 125
R+ +EA E Q + +L+ ++ + E +A G L+ +
Sbjct: 1891 RQLEEAEEESQRINANRRKLQRELDEATESNEAMGREVNALKSK 1934
>gi|13124875 smooth muscle myosin heavy chain 11 isoform SM2A [Homo
sapiens]
Length = 1938
Score = 72.0 bits (175), Expect = 8e-13
Identities = 86/359 (23%), Positives = 152/359 (42%), Gaps = 40/359 (11%)
Query: 6 LQKQQAPRMDTPPPEERLEKQNEKLNNQEEETEFKELDGLREALANLRGLSEEERSEKAM 65
L++++A R +LEK + ++ E E +D L+ R L EE S+
Sbjct: 959 LEEEEAARQKL-----QLEKVTAEAKIKKLEDEILVMDDQNNKLSKERKLLEERISDLTT 1013
Query: 66 LRSRIEEQSQLICILKRRSDEALERCQILELLNAELEEKMMQEAEKLKAQ---------- 115
+ EE+++ + LK + + + ++ + EEK QE EKLK +
Sbjct: 1014 NLAEEEEKAKNLTKLKNKHESMISELEV----RLKKEEKSRQELEKLKRKLEGDASDFHE 1069
Query: 116 --GEYSRKLEERFMTLAANHE----LMLRFKDEYKSENIKLREENEKLRLENS-SLFSQA 168
+ ++ E M LA E + R DE +N L++ E LE S +
Sbjct: 1070 QIADLQAQIAELKMQLAKKEEELQAALARLDDEIAQKNNALKKIRE---LEGHISDLQED 1126
Query: 169 LKDEEAKVLQLTVRCEALTGELETLKERCAQDACQAQAREKELLELQSQQACTHTK---- 224
L E A + + L ELE LK +D + A ++EL + Q+ K
Sbjct: 1127 LDSERAARNKAEKQKRDLGEELEALKTEL-EDTLDSTATQQELRAKREQEVTVLKKALDE 1185
Query: 225 ETEQLRSQLQTLKQQHQQAVEQIAKAEETHSSLSQELQARLQTVTREKEELLQLSIERGK 284
ET +Q+Q ++Q+H QAVE++ + E L QT+ +E +L +
Sbjct: 1186 ETRSHEAQVQEMRQKHAQAVEELTEQLEQFKRAKANLDKNKQTLEKENADL----AGELR 1241
Query: 285 VLQNKQAEICQLEEKLEIANEDRKHALERFEQEAVAVDSNLRVRELQRKVDGIQKAYDE 343
VL + E+ ++KLE ++ + + E + N +V +LQ +V+ + +E
Sbjct: 1242 VLGQAKQEVEHKKKKLEAQVQELQSKCS--DGERARAELNDKVHKLQNEVESVTGMLNE 1298
Score = 63.2 bits (152), Expect = 4e-10
Identities = 92/409 (22%), Positives = 179/409 (43%), Gaps = 47/409 (11%)
Query: 6 LQKQQAPRMDTPPPEERLEKQNEKLNNQEEET-----EFKELDGLREALANL--RGLSEE 58
L ++A R + L ++ E L + E+T +EL RE + + L EE
Sbjct: 1127 LDSERAARNKAEKQKRDLGEELEALKTELEDTLDSTATQQELRAKREQEVTVLKKALDEE 1186
Query: 59 ERSEKAMLRSRIEEQSQLICILKRRSDEALERCQILELLNAELEEKMMQEAEKLKAQGEY 118
RS +A ++ ++ +Q + L + ++ L+ LE++ A +L+ G+
Sbjct: 1187 TRSHEAQVQEMRQKHAQAVEELTEQLEQFKRAKANLDKNKQTLEKENADLAGELRVLGQA 1246
Query: 119 SRKLEERFMTLAAN-HELMLRFKD------EYKSENIKLREENE--------------KL 157
+++E + L A EL + D E + KL+ E E KL
Sbjct: 1247 KQEVEHKKKKLEAQVQELQSKCSDGERARAELNDKVHKLQNEVESVTGMLNEAEGKAIKL 1306
Query: 158 RLENSSLFSQA------LKDEEAKVLQLTVRCEALTGELETLKERCAQDACQAQAREKEL 211
+ +SL SQ L++E + L ++ + L E +L+++ ++ Q E+ +
Sbjct: 1307 AKDVASLSSQLQDTQELLQEETRQKLNVSTKLRQLEEERNSLQDQLDEEMEAKQNLERHI 1366
Query: 212 LELQSQQACTHTKETEQLRSQLQTL---KQQHQQAVEQIAKAEETHSSLSQELQARLQTV 268
L Q + + K+ + S ++ L K++ Q+ +E + + E ++ +L+ +
Sbjct: 1367 STLNIQLSDSK-KKLQDFASTVEALEEGKKRFQKEIENLTQQYEEKAAAYDKLEKTKNRL 1425
Query: 269 TREKEELL-QLSIERGKV--LQNKQAEICQL--EEKLEIANEDRKHALERFEQEAVAVDS 323
+E ++L+ L +R V L+ KQ + QL EEK N K+A ER EA A +
Sbjct: 1426 QQELDDLVVDLDNQRQLVSNLEKKQRKFDQLLAEEK----NISSKYADERDRAEAEAREK 1481
Query: 324 NLRVRELQRKVDGIQKAYDELRLQSEAFKKHSLDLLSKERELNGKLRHL 372
+ L R ++ +A +EL ++ K DL+S + ++ + L
Sbjct: 1482 ETKALSLARALEEALEAKEELERTNKMLKAEMEDLVSSKDDVGKNVHEL 1530
Score = 59.3 bits (142), Expect = 5e-09
Identities = 96/398 (24%), Positives = 178/398 (44%), Gaps = 75/398 (18%)
Query: 20 EERLEKQNEKLNNQEEETEFKELDGLR-----EALA-----NLRGLSEEERSEKAMLRSR 69
E ++E+ +L E+E + E LR +AL +L+ E+ ++ L+ +
Sbjct: 1538 ETQMEEMKTQLEELEDELQATEDAKLRLEVNMQALKGQFERDLQARDEQNEEKRRQLQRQ 1597
Query: 70 IEE----------QSQLICILKRRSDEALERCQILELLNAELEEKMMQEAEKLKAQ-GEY 118
+ E Q L K++ + L+ ++ + E+ +++ KL+AQ ++
Sbjct: 1598 LHEYETELEDERKQRALAAAAKKKLEGDLKDLELQADSAIKGREEAIKQLRKLQAQMKDF 1657
Query: 119 SRKLE-------ERFMTLAANH--------ELMLRFKDEYKSENIKLREENEKLRLEN-- 161
R+LE E F T N +LM +D +E + + + EK L
Sbjct: 1658 QRELEDARASRDEIFATAKENEKKAKSLEADLMQLQEDLAAAERARKQADLEKEELAEEL 1717
Query: 162 -SSLFSQ-ALKDE----EAKVLQLTVRCEALTGELETLKERCAQDACQAQAREKELLELQ 215
SSL + AL+DE EA++ QL E G +E + +R + QA+ EL +
Sbjct: 1718 ASSLSGRNALQDEKRRLEARIAQLEEELEEEQGNMEAMSDRVRKATQQAEQLSNELATER 1777
Query: 216 SQQACTHT------KETEQLRSQLQ----TLKQQHQQAV----EQIAKAEETHSSLSQEL 261
S + ++ ++LRS+L +K + + + +IA+ EE ++E
Sbjct: 1778 STAQKNESARQQLERQNKELRSKLHEMEGAVKSKFKSTIAALEAKIAQLEEQVEQEAREK 1837
Query: 262 QARLQTVTRE----KEELLQLSIERGKVLQNKQAEICQLEEKLEIAN---EDRKHALERF 314
QA +++ ++ KE LLQ+ ER K AE Q +E+ E N + K LE
Sbjct: 1838 QAATKSLKQKDKKLKEILLQVEDER------KMAE--QYKEQAEKGNARVKQLKRQLEEA 1889
Query: 315 EQEAVAVDSNLRVRELQRKVDGIQKAYDELRLQSEAFK 352
E+E+ +++N R+LQR++D ++ + + + A K
Sbjct: 1890 EEESQRINANR--RKLQRELDEATESNEAMGREVNALK 1925
Score = 52.8 bits (125), Expect = 5e-07
Identities = 77/356 (21%), Positives = 148/356 (41%), Gaps = 27/356 (7%)
Query: 26 QNEKLNNQEEETEFKELDGLREALANLRGLSEEERSEKAMLRSRIEEQSQLICILKRRSD 85
+ ++ + E E K L R L E ER+ K ML++ +E+ + +
Sbjct: 1470 ERDRAEAEAREKETKALSLARALEEALEAKEELERTNK-MLKAEMEDLVSSKDDVGKNVH 1528
Query: 86 EALERCQILELLNAELEEKMMQEAEKLKAQGEYSRKLEERFMTLAANHELMLRFKDEYKS 145
E + + LE E++ ++ + ++L+A + +LE L E L+ +DE
Sbjct: 1529 ELEKSKRALETQMEEMKTQLEELEDELQATEDAKLRLEVNMQALKGQFERDLQARDEQNE 1588
Query: 146 ENIKLREENEKLRLENSSLFSQALKDEEAKVLQLTVRCEALTGELETLKERCAQDACQAQ 205
E K R+ +L + L+DE + + L G+L+ L+ + +
Sbjct: 1589 E--KRRQLQRQLH-----EYETELEDERKQRALAAAAKKKLEGDLKDLELQADSAIKGRE 1641
Query: 206 AREKELLELQSQQACTHTKETEQLRSQ----LQTLKQQHQQAVEQIAKAEETHSSLSQEL 261
K+L +LQ+Q +E E R+ T K+ ++A A + L+
Sbjct: 1642 EAIKQLRKLQAQMK-DFQRELEDARASRDEIFATAKENEKKAKSLEADLMQLQEDLAAAE 1700
Query: 262 QARLQTVTREKEEL---LQLSIERGKVLQNK----QAEICQLEEKLEIANEDRKHALERF 314
+AR Q EKEEL L S+ LQ++ +A I QLEE+LE + + +R
Sbjct: 1701 RARKQ-ADLEKEELAEELASSLSGRNALQDEKRRLEARIAQLEEELEEEQGNMEAMSDRV 1759
Query: 315 EQEAVAVDSNLRVRELQRKVDGIQKAYDELRLQSEAFKKHSLDLLSKERELNGKLR 370
+ + + +L ++ + + + ++ + +L SK E+ G ++
Sbjct: 1760 RK------ATQQAEQLSNELATERSTAQKNESARQQLERQNKELRSKLHEMEGAVK 1809
Score = 52.4 bits (124), Expect = 7e-07
Identities = 84/375 (22%), Positives = 153/375 (40%), Gaps = 75/375 (20%)
Query: 6 LQKQQAP-RMDTPPPEERLEKQNEKLNNQEEETEFKELDGLREALANLRGLSEEERSEKA 64
LQ Q A +M EE L+ +L+++ + L +RE ++ L E+ SE+A
Sbjct: 1074 LQAQIAELKMQLAKKEEELQAALARLDDEIAQKN-NALKKIRELEGHISDLQEDLDSERA 1132
Query: 65 MLRSRIEEQSQLICILKRRSDEALE--RCQILELLNA-----ELEEKMMQEAEKLK-AQG 116
R++ E+Q KR E LE + ++ + L++ EL K QE LK A
Sbjct: 1133 A-RNKAEKQ-------KRDLGEELEALKTELEDTLDSTATQQELRAKREQEVTVLKKALD 1184
Query: 117 EYSRKLEERFMTLAANH----ELMLRFKDEYKSENIKLREENEKLRLENSSLFSQALKDE 172
E +R E + + H E + +++K L + + L EN+ L
Sbjct: 1185 EETRSHEAQVQEMRQKHAQAVEELTEQLEQFKRAKANLDKNKQTLEKENADL-------- 1236
Query: 173 EAKVLQLTVRCEALTGELETLKERCAQDACQAQAREKELLELQSQQACTHTKETEQLRSQ 232
GEL L + A Q +K+ LE Q Q+ + + E+ R++
Sbjct: 1237 --------------AGELRVLGQ-----AKQEVEHKKKKLEAQVQELQSKCSDGERARAE 1277
Query: 233 LQTLKQQHQQAVEQIA-----------KAEETHSSLSQELQARLQTVTREKEELLQLSIE 281
L + Q VE + K + +SLS +LQ + + E + L +S +
Sbjct: 1278 LNDKVHKLQNEVESVTGMLNEAEGKAIKLAKDVASLSSQLQDTQELLQEETRQKLNVSTK 1337
Query: 282 RGKVLQNKQAEICQLEEKLE-------------IANEDRKHALERFEQEAVAVDSNLRVR 328
++ + + + QL+E++E I D K L+ F A++ +
Sbjct: 1338 LRQLEEERNSLQDQLDEEMEAKQNLERHISTLNIQLSDSKKKLQDFASTVEALEEG--KK 1395
Query: 329 ELQRKVDGIQKAYDE 343
Q++++ + + Y+E
Sbjct: 1396 RFQKEIENLTQQYEE 1410
Score = 47.0 bits (110), Expect = 3e-05
Identities = 44/168 (26%), Positives = 80/168 (47%), Gaps = 17/168 (10%)
Query: 209 KELLELQSQQACTHTKETEQLRSQLQTLKQQHQQAVEQIAKAEETHSSLSQE---LQARL 265
K LL++ Q+ KE E LQ K++ Q+A ++ + E+ HS L++E LQ +L
Sbjct: 842 KPLLQVTRQEEEMQAKEDE-----LQKTKERQQKAENELKELEQKHSQLTEEKNLLQEQL 896
Query: 266 QTVTREKEELLQLSIERGKVLQNKQAEICQLEEKLEIANEDRKHALE----RFEQEAVAV 321
Q T E ++ + Q + + ++E +LE EDR L+ + Q+ + +
Sbjct: 897 QAETELYAEAEEMRVRLAAKKQELEEILHEMEARLE-EEEDRGQQLQAERKKMAQQMLDL 955
Query: 322 DSNLRVRELQRKVDGIQKAYDELRLQSEAFKKHSLD----LLSKEREL 365
+ L E R+ ++K E +++ + +D LSKER+L
Sbjct: 956 EEQLEEEEAARQKLQLEKVTAEAKIKKLEDEILVMDDQNNKLSKERKL 1003
Score = 46.6 bits (109), Expect = 4e-05
Identities = 52/215 (24%), Positives = 99/215 (46%), Gaps = 25/215 (11%)
Query: 167 QALKDEEAKVLQLTVRCEALTGELETLKERCAQDACQAQAREKELLELQSQQACTHTKET 226
QA +DE K + + E EL+ L+++ +Q EK LL+ Q Q E
Sbjct: 855 QAKEDELQKTKERQQKAE---NELKELEQKHSQ-----LTEEKNLLQEQLQAETELYAEA 906
Query: 227 EQLRSQLQTLKQQHQQAVEQIAKAEETHSSLSQELQARLQTVTRE----KEELLQLSIER 282
E++R +L KQ+ ++ + ++ E Q+LQA + + ++ +E+L + R
Sbjct: 907 EEMRVRLAAKKQELEEILHEMEARLEEEEDRGQQLQAERKKMAQQMLDLEEQLEEEEAAR 966
Query: 283 GKVLQNK---QAEICQLEEK-LEIANEDRKHALERFEQEAVAVDSNLRVRELQRKVDGIQ 338
K+ K +A+I +LE++ L + +++ K + ER E D + E + K +
Sbjct: 967 QKLQLEKVTAEAKIKKLEDEILVMDDQNNKLSKERKLLEERISDLTTNLAEEEEKAKNLT 1026
Query: 339 KAYD---------ELRLQSEAFKKHSLDLLSKERE 364
K + E+RL+ E + L+ L ++ E
Sbjct: 1027 KLKNKHESMISELEVRLKKEEKSRQELEKLKRKLE 1061
Score = 46.6 bits (109), Expect = 4e-05
Identities = 66/282 (23%), Positives = 127/282 (45%), Gaps = 29/282 (10%)
Query: 6 LQKQQAPRMDTPPPEERLEKQNEKLNNQEEETEFKELDGLREALANLR-GLSEEERSEKA 64
L+K QA D E +++ +E E K+ L L L+ L+ ER+ K
Sbjct: 1647 LRKLQAQMKDFQRELEDARASRDEIFATAKENE-KKAKSLEADLMQLQEDLAAAERARKQ 1705
Query: 65 MLRSRIEEQSQLICILKRRSDEALERCQILELLNAELEEKMMQEAEKLKAQGEYSRKLEE 124
+ E +L L R+ E+ + LE A+LEE++ +E ++A + RK +
Sbjct: 1706 ADLEKEELAEELASSLSGRNALQDEKRR-LEARIAQLEEELEEEQGNMEAMSDRVRKATQ 1764
Query: 125 RFMTLAANHELMLRFKDEYKSENIK--LREENEKLR-----LENS--SLFSQALKDEEAK 175
+ L+ +EL K+E+ + L +N++LR +E + S F + EAK
Sbjct: 1765 QAEQLS--NELATERSTAQKNESARQQLERQNKELRSKLHEMEGAVKSKFKSTIAALEAK 1822
Query: 176 VLQLTVRCE-------ALTGELETLKERCAQDACQAQAREKELLELQSQQACTHTKETEQ 228
+ QL + E A T L+ ++ + Q + E+++ E +QA +Q
Sbjct: 1823 IAQLEEQVEQEAREKQAATKSLKQKDKKLKEILLQVED-ERKMAEQYKEQAEKGNARVKQ 1881
Query: 229 LRSQLQTLKQQHQ-------QAVEQIAKAEETHSSLSQELQA 263
L+ QL+ +++ Q + ++ +A E++ ++ +E+ A
Sbjct: 1882 LKRQLEEAEEESQRINANRRKLQRELDEATESNEAMGREVNA 1923
Score = 30.8 bits (68), Expect = 2.1
Identities = 24/104 (23%), Positives = 49/104 (47%), Gaps = 1/104 (0%)
Query: 22 RLEKQNEKLNNQEEETEFKELDGLREALANLRGLSEEERSEKAMLRSRIEEQSQLICILK 81
+LE+Q E+ +E++ K L + L + E+ER + + E+ + + LK
Sbjct: 1825 QLEEQVEQ-EAREKQAATKSLKQKDKKLKEILLQVEDERKMAEQYKEQAEKGNARVKQLK 1883
Query: 82 RRSDEALERCQILELLNAELEEKMMQEAEKLKAQGEYSRKLEER 125
R+ +EA E Q + +L+ ++ + E +A G L+ +
Sbjct: 1884 RQLEEAEEESQRINANRRKLQRELDEATESNEAMGREVNALKSK 1927
>gi|239756241 PREDICTED: golgi autoantigen, golgin subfamily a-like
[Homo sapiens]
Length = 899
Score = 71.6 bits (174), Expect = 1e-12
Identities = 85/356 (23%), Positives = 167/356 (46%), Gaps = 38/356 (10%)
Query: 20 EERLEKQNEKLNNQEEETEFKELDGLREALANLRGLSEEERSEKAMLRSRIEEQSQLICI 79
EERL +Q K+ QEE+ +++ LRE LR +E R +K + + Q Q
Sbjct: 299 EERLREQEGKMREQEEKM-WRQEKRLREQEKELREQEKELREQKELREQEEQMQEQ---- 353
Query: 80 LKRRSDEALERCQILELLNAELEEKMMQEAEKLKAQGEYSRKLEERFMTLAANHELMLRF 139
+ + E E+ + E EE++ ++ ++++ Q + R EER + LR
Sbjct: 354 -EEKMWEQEEKMREQEEKMWRQEERLWEQEKQMREQEQKMRDQEERMW----EQDERLRE 408
Query: 140 KDEYKSENIKLREENEKLRLENSSLFSQ-ALKDEEAKVLQ---LTVRCEALTGELETLKE 195
K+E E K+ E+ EK+R E + +D+E K+ + + R + + E ET++E
Sbjct: 409 KEERMREQEKMWEQVEKMREEKKMQEQEKKTRDQEEKMQEEERIREREKKMREEEETMRE 468
Query: 196 RCAQDACQAQAR---EKELLELQSQQACTHTKETEQLRSQLQTLKQQHQQAVEQIAKAEE 252
+ ++ Q Q E+E E Q Q+ ++ E+L Q + +++Q ++ EQ K +
Sbjct: 469 Q--EEKMQKQEENMWEQEEKEWQQQRL---PEQKEKLWEQ-EKMQEQEEKIWEQEEKIRD 522
Query: 253 THSSLSQELQARLQTVTREKEELLQLSIERGKVLQNKQAEICQLEEKLEIANEDRKHALE 312
QE + Q RE+E+ + E+ + +++++ ++ EE++E +
Sbjct: 523 QEEMWGQEKKMWRQEKMREQEDQMW---EQEEKMRDQEQKMWDQEERMEKKTQ------- 572
Query: 313 RFEQEAVAVDSNLRVRELQRKVDGIQKAYDE---LRLQSEAFKKHSLDLLSKEREL 365
EQE D ++RE +R + +K +E +R Q E ++ + +E ++
Sbjct: 573 --EQEKKTWDQEEKMREEERMREREKKMREEEEMMREQEEKMQEQEEKMQEQEEKM 626
Score = 66.6 bits (161), Expect = 3e-11
Identities = 76/368 (20%), Positives = 168/368 (45%), Gaps = 36/368 (9%)
Query: 7 QKQQAPRMDTPPPEERLE-----KQNEKLNNQEEETEFKELDGLREALANLRGLSEEE-- 59
+K Q T EE+++ ++ EK +EEET ++ + +++ N+ E+E
Sbjct: 430 KKMQEQEKKTRDQEEKMQEEERIREREKKMREEEETMREQEEKMQKQEENMWEQEEKEWQ 489
Query: 60 ------RSEKAMLRSRIEEQSQLICIL--KRRSDEAL---ERCQILELLNAELEEKMMQE 108
+ EK + +++EQ + I K R E + E+ + E E++M ++
Sbjct: 490 QQRLPEQKEKLWEQEKMQEQEEKIWEQEEKIRDQEEMWGQEKKMWRQEKMREQEDQMWEQ 549
Query: 109 AEKLKAQGEYSRKLEERFMTLAANHELMLRFKDEYKSENIKLREENEKLRLENSSLFSQ- 167
EK++ Q + EER E ++E E ++RE +K+R E + Q
Sbjct: 550 EEKMRDQEQKMWDQEERMEKKTQEQEKKTWDQEEKMREEERMREREKKMREEEEMMREQE 609
Query: 168 -ALKDEEAKVLQLTVRCEALTGELETLKERCAQDACQAQAREKELLEL-----QSQQACT 221
++++E K+ + + +++ +E+ + + +E+++ E Q ++
Sbjct: 610 EKMQEQEEKMQEQEEKMWEQEEKMQEQEEKMWEQEEKMWEQEEKMWEQQRLPEQKEKLWE 669
Query: 222 HTKETEQLRSQLQTLKQQHQQAVEQIAKAEETHSSLSQELQARLQTVTREKEELLQLSIE 281
H K EQ + Q Q K Q+ +E+ K +E + + R + RE+E+ ++ E
Sbjct: 670 HEKMQEQEKMQEQEEKIWEQEKMEK--KTQEQEKKTWDQEKMREEESMREREKKMR---E 724
Query: 282 RGKVLQNKQAEICQLEEKLEIANEDRKHALERFEQEAVAVDSNLRVRELQRKVDGIQKAY 341
++++ ++ ++ + EEK++ E E +EQE + ++ E QR + +K +
Sbjct: 725 EEEMMREQEEKMQEQEEKMQEQEE------EMWEQEEKMWEQEEKMWEQQRLPEQKEKLW 778
Query: 342 DELRLQSE 349
+ ++Q +
Sbjct: 779 EHEKMQEQ 786
Score = 65.5 bits (158), Expect = 8e-11
Identities = 76/375 (20%), Positives = 176/375 (46%), Gaps = 26/375 (6%)
Query: 7 QKQQAPRMDTPPPEERLEKQNEKLNNQEEETEFKELDGLREALANLRGLSEEERSEKAML 66
+K+ + + EE++++Q EK+ QEE+ +E R+ L ++ R ++ +
Sbjct: 334 EKELREQKELREQEEQMQEQEEKMWEQEEKMREQEEKMWRQE-ERLWEQEKQMREQEQKM 392
Query: 67 RSRIEEQSQLICILKRRSDEALERCQILELLNAELEEKMMQEAEKLKAQGEYSRKLEERF 126
R + E + L+ + + E+ ++ E + EEK MQE EK E + EER
Sbjct: 393 RDQEERMWEQDERLREKEERMREQEKMWEQVEKMREEKKMQEQEKKTRDQEEKMQEEERI 452
Query: 127 MTLAANHELMLRFKDEYKSENIKLREENEKLRLENSSLFSQALKDEEAKVL----QLTVR 182
E +R ++E +RE+ EK++ + +++ Q K+ + + L +
Sbjct: 453 ----REREKKMREEEE------TMREQEEKMQKQEENMWEQEEKEWQQQRLPEQKEKLWE 502
Query: 183 CEALTGELETL--KERCAQDACQAQAREKEL--LELQSQQACTHTKETEQLRSQLQTLKQ 238
E + + E + +E +D + +EK++ E +Q ++ E++R Q Q +
Sbjct: 503 QEKMQEQEEKIWEQEEKIRDQEEMWGQEKKMWRQEKMREQEDQMWEQEEKMRDQEQKMWD 562
Query: 239 QHQQAVEQIAKAEETHSSLSQELQARLQTVTREKEELL----QLSIERGKVLQNKQAEIC 294
Q ++ ++ + E+ + QE + R + RE+E+ + ++ E+ + +Q ++ ++
Sbjct: 563 QEERMEKKTQEQEK--KTWDQEEKMREEERMREREKKMREEEEMMREQEEKMQEQEEKMQ 620
Query: 295 QLEEKLEIANEDRKHALER-FEQEAVAVDSNLRVRELQRKVDGIQKAYDELRLQSEAFKK 353
+ EEK+ E + E+ +EQE + ++ E QR + +K ++ ++Q + +
Sbjct: 621 EQEEKMWEQEEKMQEQEEKMWEQEEKMWEQEEKMWEQQRLPEQKEKLWEHEKMQEQEKMQ 680
Query: 354 HSLDLLSKERELNGK 368
+ + ++ ++ K
Sbjct: 681 EQEEKIWEQEKMEKK 695
Score = 62.4 bits (150), Expect = 6e-10
Identities = 67/322 (20%), Positives = 151/322 (46%), Gaps = 27/322 (8%)
Query: 40 KELDGLREALANLRGLSEEERSEKAMLRSRI---EEQSQLICILKRRSDEALERCQIL-- 94
KE D L L +EE + + A L+ ++ E + I + + LER + L
Sbjct: 204 KERDALSLELYRNTITNEELKKKNAELQEKLPLAESEKSEIQLNVKELKRKLERAKFLLP 263
Query: 95 ELLNAELEEKMMQEAEKLKAQGEYSRKLEERFM-----------TLAANHELMLRFKDEY 143
++ L+E+M ++ E+L+ Q + RK EE+ + E M R +
Sbjct: 264 QVQTNTLQEEMWRQEEELREQEKKIRKQEEKMWRQEERLREQEGKMREQEEKMWRQEKRL 323
Query: 144 KSENIKLREENEKLRLENSSLFSQ--ALKDEEAKVLQLTVRCEALTGELETLKERCAQDA 201
+ + +LRE+ ++LR E L Q ++++E K+ + + ++ +ER +
Sbjct: 324 REQEKELREQEKELR-EQKELREQEEQMQEQEEKMWEQEEKMREQEEKMWRQEERLWEQE 382
Query: 202 CQAQAREKELLELQSQQACTHTKETEQLRSQLQTLKQQHQQAVEQIAKAEETHSSLSQEL 261
Q + +E+++ + + + ++ E+LR + + +++Q ++ EQ+ K E QE
Sbjct: 383 KQMREQEQKMRDQEERM----WEQDERLREKEERMREQ-EKMWEQVEKMREEKKMQEQEK 437
Query: 262 QARLQTVTREKEELLQLSIERGKVLQNKQAEICQLEEKLEIANEDRKHALERFEQEAVAV 321
+ R Q ++EE ++ ER K ++ ++ + + EEK++ E+ E+ Q+
Sbjct: 438 KTRDQEEKMQEEERIR---EREKKMREEEETMREQEEKMQKQEENMWEQEEKEWQQQRLP 494
Query: 322 DSNLRVRELQRKVDGIQKAYDE 343
+ ++ E ++ + +K +++
Sbjct: 495 EQKEKLWEQEKMQEQEEKIWEQ 516
Score = 45.4 bits (106), Expect = 8e-05
Identities = 43/165 (26%), Positives = 75/165 (45%), Gaps = 12/165 (7%)
Query: 7 QKQQAPRMDTPPPEERLEKQNEKLNNQEEET-EFKELDGLREALANLRGLSEEERSEKAM 65
+K Q EE + +Q EK+ QEE+ E + L +E L + E+E+ +
Sbjct: 734 EKMQEQEEKMQEQEEEMWEQEEKMWEQEEKMWEQQRLPEQKEKLWEHEKMQEQEKIWEQE 793
Query: 66 LRSRIEEQSQLICILKRRSDEALERCQILELLNAE-----LEEKMMQEAEKLKAQGEYSR 120
+ R +E+ K R E R Q ++ E EEKM + EK+ Q E
Sbjct: 794 EKMRDQEEKMRGQEEKMRGQEEKMRGQEEKMWGQEEKMWGQEEKMWGQEEKMWGQEE--- 850
Query: 121 KLEERFMTLAANHELMLRFKDEYKSENIKLREENEKLRLENSSLF 165
K+EE+ + E M +++ + + K+RE+ EK+R + ++
Sbjct: 851 KMEEK---MQGQEEKMREQEEKMRGQEEKMREQEEKMRGQEEKIY 892
Score = 41.2 bits (95), Expect = 0.002
Identities = 49/243 (20%), Positives = 111/243 (45%), Gaps = 37/243 (15%)
Query: 6 LQKQQAPRMDTPPPEERLEKQNEKLNNQE---EETEFKELDG-LREALANLRGLSEEERS 61
+Q+Q+ + E++ ++Q +K +QE EE +E + +RE +R E+ +
Sbjct: 679 MQEQEEKIWEQEKMEKKTQEQEKKTWDQEKMREEESMREREKKMREEEEMMREQEEKMQE 738
Query: 62 EKAMLRSRIEEQSQLICILKRRSDEALERCQILELLNAELEEKMMQEAEKLKAQGEYSRK 121
++ ++ + EE + + + ++ E+ ++ E E + MQE EK+ Q E R
Sbjct: 739 QEEKMQEQEEEMWEQEEKMWEQEEKMWEQQRLPEQKEKLWEHEKMQEQEKIWEQEEKMRD 798
Query: 122 LEERFMTLAANHELMLRFKDEYKSENIKLREENEKLRLENSSLFSQALK--DEEAKVLQL 179
EE+ + + K+R + EK+R + ++ Q K +E K +
Sbjct: 799 QEEKM-----------------RGQEEKMRGQEEKMRGQEEKMWGQEEKMWGQEEK---M 838
Query: 180 TVRCEALTGELETLKERCAQDACQAQAREKELLELQSQQACTHTKETEQLRSQLQTLKQQ 239
+ E + G+ E ++E+ Q +E+++ E + + + E++R Q + ++ Q
Sbjct: 839 WGQEEKMWGQEEKMEEK-------MQGQEEKMREQEEKM----RGQEEKMREQEEKMRGQ 887
Query: 240 HQQ 242
++
Sbjct: 888 EEK 890
>gi|22538393 A-kinase anchor protein 9 isoform 3 [Homo sapiens]
Length = 3899
Score = 71.6 bits (174), Expect = 1e-12
Identities = 101/423 (23%), Positives = 176/423 (41%), Gaps = 71/423 (16%)
Query: 1 MRAPMLQKQQAPRMDTPPPEERLEKQNEKLNNQEEETEFKELDGLREALANLRGLSEEER 60
MR QKQ+A E R E ++ E + +G+ + A+ + L E +
Sbjct: 1879 MRESFRQKQEATESLKCQEELRERLHEESRAREQLAVELSKAEGVIDGYADEKTLFERQI 1938
Query: 61 SEKAMLRSRIEEQSQLICILKRRSDEALERCQILE----------LLNAE---LEEKMMQ 107
EK + R+E++ L+C R + E+ QI E + AE +E++++Q
Sbjct: 1939 QEKTDIIDRLEQE--LLCASNRLQELEAEQQQIQEERELLSRQKEAMKAEAGPVEQQLLQ 1996
Query: 108 EAEKL------------KAQGEYSRKLEERFMTLAANHELMLRFKDEYKSENIKLREENE 155
E EKL K + + ++++ + + + + E +E + LR++N+
Sbjct: 1997 ETEKLMKEKLEVQCQAEKVRDDLQKQVKALEIDVEEQVSRFIELEQEKNTELMDLRQQNQ 2056
Query: 156 KL--RLENSSLF--SQAL-KDEEAKVLQLTVR---------------CEALTGELETLKE 195
L +LE F QA+ ++ E V Q ++ E T E+E L
Sbjct: 2057 ALEKQLEKMRKFLDEQAIDREHERDVFQQEIQKLEQQLKVVPRFQPISEHQTREVEQLAN 2116
Query: 196 RCAQ--DACQAQAREKELLELQSQQACTHTKETEQLRSQLQTLKQ-------QHQQAVEQ 246
+ D C KE L+ Q+ +E E+L +++ L+Q +H AVE
Sbjct: 2117 HLKEKTDKCSELLLSKEQLQRDIQE---RNEEIEKLEFRVRELEQALLVEDRKHFGAVE- 2172
Query: 247 IAKAEETHSSLSQELQARLQTVTREKEELLQLSIERGKV---LQNKQAEICQLEEKLEIA 303
AK E SL +LQA + R+++E+ L + + L+NK E+ QL +LEI
Sbjct: 2173 -AKPE---LSLEVQLQAERDAIDRKEKEITNLEEQLEQFREELENKNEEVQQLHMQLEIQ 2228
Query: 304 NEDRKHALERFEQEAVAVDSNLRVRELQRKVDGIQKAYDELRLQSEAFKKHSLDLLSKER 363
++ L+ EQE ++ L K D Q F K + + KE
Sbjct: 2229 KKESTTRLQELEQENKLFKDDMEKLGLAIKESDAMSTQD----QHVLFGKFAQIIQEKEV 2284
Query: 364 ELN 366
E++
Sbjct: 2285 EID 2287
Score = 62.8 bits (151), Expect = 5e-10
Identities = 79/356 (22%), Positives = 155/356 (43%), Gaps = 32/356 (8%)
Query: 7 QKQQAPRMDTPPPEERLEKQN--EKLNNQEEETEFKELDGLREALANLRGLSEEERSEKA 64
+ +Q +++ EE EK+ E+LN + E E K L+ L++ L L E + +
Sbjct: 309 EMEQDKKVENSNKEEIQEKETIIEELNTKIIEEEKKTLE-LKDKLTTADKLLGELQEQIV 367
Query: 65 MLRSRIEEQSQLICILKRRSDEALERCQILELLNAELEEKMMQEAE-----KLKAQGEYS 119
I+ + K++ ++ E + L EL+++ ++++ + + E
Sbjct: 368 QKNQEIKNMKLELTNSKQKERQSSEEIKQLMGTVEELQKRNHKDSQFETDIVQRMEQETQ 427
Query: 120 RKLEERFMTLAANH-ELMLRFKDEYKSENIKLREE---NEKLRLENSSLFSQALKDEEAK 175
RKLE+ L + + +++ K E +++ EE K +EN+ + E +
Sbjct: 428 RKLEQLRAELDEMYGQQIVQMKQELIRQHMAQMEEMKTRHKGEMENALRSYSNITVNEDQ 487
Query: 176 VLQLTVRCEALTGELETLKERCAQDACQAQAREKELLELQSQQACTHTKETEQLRSQLQT 235
+ + V L +L QD + + KE L L ++ C ++ E L +L
Sbjct: 488 IKLMNVAINELNIKL--------QDTNSQKEKLKEELGLILEEKCALQRQLEDLVEELSF 539
Query: 236 LKQQHQQA----VEQIAKAEETHSSLSQELQARLQTVTREKEELLQLSIERGKVLQNKQA 291
++Q Q+A EQ +K E H SLS TV K E++ S R ++ +A
Sbjct: 540 SREQIQRARQTIAEQESKLNEAHKSLS--------TVEDLKAEIVSASESRKELELKHEA 591
Query: 292 EICQLEEKLEIANEDRKHALERFEQEAVAVDSNLRVRELQRKVDGIQKAYDELRLQ 347
E+ + KLE+ +++ L+R + A LR + L + + K ++L ++
Sbjct: 592 EVTNYKIKLEMLEKEKNAVLDRMAESQEAELERLRTQLLFSHEEELSKLKEDLEIE 647
Score = 58.9 bits (141), Expect = 7e-09
Identities = 73/369 (19%), Positives = 161/369 (43%), Gaps = 61/369 (16%)
Query: 6 LQKQQAPRMDTPPPEERLEKQNEKLNNQEEETEFKELDGLREALANLRGLSEEERSEKAM 65
L +Q +M+ + E +N + ++ + A+ L ++ S+K
Sbjct: 452 LIRQHMAQMEEMKTRHKGEMENALRSYSNITVNEDQIKLMNVAINELNIKLQDTNSQKEK 511
Query: 66 LRSRIEEQSQLICILKRRSDEALERCQILELLNAELEEKMMQEAEKLKAQGEYSRKLEER 125
L+ + + C L+R+ ++ +E + +Q A + A+ E KL E
Sbjct: 512 LKEELGLILEEKCALQRQLEDLVE--------ELSFSREQIQRARQTIAEQE--SKLNEA 561
Query: 126 FMTLAANHELMLRFKDEYKSENIKLREENEKLRLENSSLFSQALKDEEAKVLQLTVRCEA 185
+L+ +L K+E + E ++L L++ EA+V ++ E
Sbjct: 562 HKSLSTVEDL--------KAEIVSASESRKELELKH-----------EAEVTNYKIKLEM 602
Query: 186 LTGELETLKERCAQDACQAQAREKELLELQSQQACTHTKETEQLRSQLQTLKQQHQQAVE 245
L E + +R A+++E EL L++Q +H +E +L+ L+ +H+ +E
Sbjct: 603 LEKEKNAVLDR------MAESQEAELERLRTQLLFSHEEELSKLKEDLEI---EHRINIE 653
Query: 246 QIAKAEETH-----SSLSQELQARLQTVTREKEELL----QLSIERGKVLQNKQA----- 291
++ H L E+ +++T+ EK+ L+ QL +E K+ +Q+
Sbjct: 654 KLKDNLGIHYKQQIDGLQNEMSQKIETMQFEKDNLITKQNQLILEISKLKDLQQSLVNSK 713
Query: 292 ------EICQLEEKLEIANEDRKH--ALERFEQEAVAVDSNLRVRELQRKVDGIQKAYDE 343
+I +L++++EI ++ K LE+ QE + + + L ++++ K + +Q+ + +
Sbjct: 714 SEEMTLQINELQKEIEILRQEEKEKGTLEQEVQE-LQLKTELLEKQMKEKENDLQEKFAQ 772
Query: 344 LRLQSEAFK 352
L ++ K
Sbjct: 773 LEAENSILK 781
Score = 57.0 bits (136), Expect = 3e-08
Identities = 91/376 (24%), Positives = 166/376 (44%), Gaps = 35/376 (9%)
Query: 21 ERLEKQNEKLNNQEEETEFKELDGLREAL--ANLRGLSEEERSEKAMLRSRIEEQSQLIC 78
E LEK+ + ++ E++ EL+ LR L ++ LS+ + + R IE+ +
Sbjct: 601 EMLEKEKNAVLDRMAESQEAELERLRTQLLFSHEEELSKLKEDLEIEHRINIEKLKDNLG 660
Query: 79 ILKRRSDEAL--ERCQILELLNAELEE------KMMQEAEKLK--AQGEYSRKLEERFMT 128
I ++ + L E Q +E + E + +++ E KLK Q + K EE MT
Sbjct: 661 IHYKQQIDGLQNEMSQKIETMQFEKDNLITKQNQLILEISKLKDLQQSLVNSKSEE--MT 718
Query: 129 LAANH-ELMLRFKDEYKSENIKLREENEKLRLENSSLFSQALKDE---EAKVLQLTVRCE 184
L N + + + + E L +E ++L+L+ L Q + E + K QL
Sbjct: 719 LQINELQKEIEILRQEEKEKGTLEQEVQELQLKTELLEKQMKEKENDLQEKFAQLEAENS 778
Query: 185 ALTGELETLKERCAQDACQAQAREKELLELQSQQACTHT----KETEQLRSQLQTLKQQH 240
L E +TL++ +Q E+ L+ L S ++ + KE E L + + LKQQ
Sbjct: 779 ILKDEKKTLEDMLKIHTPVSQ--EERLIFLDSIKSKSKDSVWEKEIEILIEENEDLKQQC 836
Query: 241 QQAVEQIAKAEETHSSLSQELQARLQTVTREKEELLQLSIERGKVLQNKQAEICQLEEKL 300
Q E+I K T S + + Q + E LL++ + + +K + + + KL
Sbjct: 837 IQLNEEIEKQRNTFSFAEKNFEVNYQELQEEYACLLKV---KDDLEDSKNKQELEYKSKL 893
Query: 301 EIANEDRKHALERFEQEAVAVDSNL------RVRELQRKVDGIQKAYDELRLQSEAFKKH 354
+ NE+ L+R V + S++ V E + ++K EL + E K+
Sbjct: 894 KALNEELH--LQRINPTTVKMKSSVFDEDKTFVAETLEMGEVVEKDTTELMEKLEVTKRE 951
Query: 355 SLDLLSKERELNGKLR 370
L+L + +L+ +L+
Sbjct: 952 KLELSQRLSDLSEQLK 967
Score = 57.0 bits (136), Expect = 3e-08
Identities = 79/322 (24%), Positives = 151/322 (46%), Gaps = 50/322 (15%)
Query: 70 IEEQSQLICILKRRSDEALERCQILELLNAELEEKMMQEAEKLKAQGEYSRKLEERFMT- 128
+EE+S L+ R AL + LLN LE+++ ++ + +A E +K + R +
Sbjct: 3027 LEERSVLLAAF-RTELTALGTTDAVGLLNC-LEQRIQEQGVEYQAAMECLQKADRRSLLS 3084
Query: 129 -LAANHELMLRFKDEYKSENIKLREENEKLRLENSSLFSQALKDEEAKVLQLTVRCEALT 187
+ A H M K K E +E+EK + L ++ +++++L++ V
Sbjct: 3085 EIQALHAQMNGRKITLKRE-----QESEK---PSQELLEYNIQQKQSQMLEMQV------ 3130
Query: 188 GELETLKERCAQDACQAQAREKELLELQSQQACTHTKETEQLRSQLQTLKQQHQQAVEQI 247
EL ++K+R + Q + + + EL+S+ A T + L++Q + LK+ +E
Sbjct: 3131 -ELSSMKDRATELQEQLSSEKMVVAELKSELAQTKLELETTLKAQHKHLKELEAFRLEVK 3189
Query: 248 AKAEETHSSLSQELQARLQTVTREKEELLQLSIERGKVLQNKQAEICQLEEKLEIANEDR 307
K +E H L + A Q +RE LQ ++E+ K A++ + EE+ + ED
Sbjct: 3190 DKTDEVH--LLNDTLASEQKKSRE----LQWALEKEK------AKLGRSEERDKEELEDL 3237
Query: 308 KHALERFEQEAVAVDSNLR-----VRELQRKVDGIQKAYD-------------ELRLQSE 349
K +LE +Q + ++ L + E Q+K++ + YD ++ L+SE
Sbjct: 3238 KFSLESQKQRNLQLNLLLEQQKQLLNESQQKIESQRMLYDAQLSEEQGRNLELQVLLESE 3297
Query: 350 AFK-KHSLDLLSKERELNGKLR 370
+ + L +EREL+ +L+
Sbjct: 3298 KVRIREMSSTLDRERELHAQLQ 3319
Score = 53.9 bits (128), Expect = 2e-07
Identities = 87/374 (23%), Positives = 165/374 (44%), Gaps = 59/374 (15%)
Query: 20 EERLEKQN-------EKLNNQEEETEFKELDGLREAL----ANLRGLSEEERSEKAMLRS 68
E+R+++Q E L + + E+ L + L+ E E+ + +L
Sbjct: 3057 EQRIQEQGVEYQAAMECLQKADRRSLLSEIQALHAQMNGRKITLKREQESEKPSQELLEY 3116
Query: 69 RIEE-QSQLICI------LKRRSDEALERCQILELLNAELEEKMMQ---EAEK-LKAQGE 117
I++ QSQ++ + +K R+ E E+ +++ AEL+ ++ Q E E LKAQ +
Sbjct: 3117 NIQQKQSQMLEMQVELSSMKDRATELQEQLSSEKMVVAELKSELAQTKLELETTLKAQHK 3176
Query: 118 YSRKLEERFMTLAANHELMLRFKDEYKSENIKLREENEKLRLENSSLFSQALKDEEAKVL 177
+ ++LE + + + + D SE K RE L E + L +D+E
Sbjct: 3177 HLKELEAFRLEVKDKTDEVHLLNDTLASEQKKSRELQWALEKEKAKLGRSEERDKE---- 3232
Query: 178 QLTVRCEALTGELETLKERCAQDACQAQAREKELL-----ELQSQQACTHTKETEQL--R 230
E L LE+ K+R Q + ++K+LL +++SQ+ + +E+
Sbjct: 3233 ----ELEDLKFSLESQKQRNLQLNLLLE-QQKQLLNESQQKIESQRMLYDAQLSEEQGRN 3287
Query: 231 SQLQTLKQQHQQAVEQIAKAEETHSSLSQELQARLQTVTRE----KEELLQLSIERGKVL 286
+LQ L + + + +++ + L +LQ+ T E+LL+ E K L
Sbjct: 3288 LELQVLLESEKVRIREMSSTLDRERELHAQLQSSDGTGQSRPPLPSEDLLK---ELQKQL 3344
Query: 287 QNKQAEICQL---EEKLEIANEDRKHALER----------FEQEAVAVDSNLRVRELQRK 333
+ K + I +L EK ++ + + +E+ EQEA + ++ ELQ K
Sbjct: 3345 EEKHSRIVELLNETEKYKLDSLQTRQQMEKDRQVHRKTLQTEQEA-NTEGQKKMHELQSK 3403
Query: 334 VDGIQKAYDELRLQ 347
V+ +Q+ +E R Q
Sbjct: 3404 VEDLQRQLEEKRQQ 3417
Score = 53.1 bits (126), Expect = 4e-07
Identities = 84/392 (21%), Positives = 179/392 (45%), Gaps = 52/392 (13%)
Query: 5 MLQKQQAPRMDTPPPEERLEKQNEKLNNQEEETEFKELDGLREALANLRG----LSEEER 60
+L++++ + + L+ + E L Q +E E + L+E A L L +E++
Sbjct: 730 ILRQEEKEKGTLEQEVQELQLKTELLEKQMKEKE----NDLQEKFAQLEAENSILKDEKK 785
Query: 61 SEKAMLR--SRIEEQSQLICI--LKRRSDEAL--ERCQILELLNAELEEKMMQEAEKLKA 114
+ + ML+ + + ++ +LI + +K +S +++ + +IL N +L+++ +Q E+++
Sbjct: 786 TLEDMLKIHTPVSQEERLIFLDSIKSKSKDSVWEKEIEILIEENEDLKQQCIQLNEEIEK 845
Query: 115 QGEY----SRKLEERFMTLAANHELMLRFKDEYK-SENIKLREENEKLRLENSSLFSQAL 169
Q + E + L + +L+ KD+ + S+N + E KL+ N L Q +
Sbjct: 846 QRNTFSFAEKNFEVNYQELQEEYACLLKVKDDLEDSKNKQELEYKSKLKALNEELHLQRI 905
Query: 170 KDEEAKVLQLTVRCEALTGELETLK--ERCAQDACQAQAR----EKELLELQ------SQ 217
K ++ +V E T ETL+ E +D + + ++E LEL S+
Sbjct: 906 NPTTVK-MKSSVFDEDKTFVAETLEMGEVVEKDTTELMEKLEVTKREKLELSQRLSDLSE 964
Query: 218 QACTHTKETEQLRSQLQTLKQQHQQAVEQIAKAE--------ETHSSLSQELQARLQTVT 269
Q E L ++++LKQ+ +Q + + E E S ++ + L V
Sbjct: 965 QLKQKHGEISFLNEEVKSLKQEKEQVSLRCRELEIIINHNRAENVQSCDTQVSSLLDGVV 1024
Query: 270 REKEELLQLSIERGKVLQNKQAEICQLEEKLEIAN-----EDRKHALERFEQEAVAVDSN 324
+ S+ + ++++I +E+K+ N E ++ L +V +S+
Sbjct: 1025 TMTSRGAEGSVSKVNKSFGEESKI-MVEDKVSFENMTVGEESKQEQLILDHLPSVTKESS 1083
Query: 325 LRVRE------LQRKVDGIQKAYDELRLQSEA 350
LR + LQ++++ ++ ++LRLQ EA
Sbjct: 1084 LRATQPSENDKLQKELNVLKSEQNDLRLQMEA 1115
Score = 53.1 bits (126), Expect = 4e-07
Identities = 90/384 (23%), Positives = 168/384 (43%), Gaps = 57/384 (14%)
Query: 18 PPEERLE-----KQNEKLNNQEEETEFKE-LDGLREALANLRGLSEEERSEKAM----LR 67
P +E LE KQ++ L Q E + K+ L+E L++ + + E +SE A L
Sbjct: 3109 PSQELLEYNIQQKQSQMLEMQVELSSMKDRATELQEQLSSEKMVVAELKSELAQTKLELE 3168
Query: 68 SRIEEQSQLICILKRRSDEALERCQILELLN----------AELEEKMMQEAEKLKAQGE 117
+ ++ Q + + L+ E ++ + LLN EL+ + +E KL E
Sbjct: 3169 TTLKAQHKHLKELEAFRLEVKDKTDEVHLLNDTLASEQKKSRELQWALEKEKAKLGRSEE 3228
Query: 118 YSRK-LEERFMTLAANHELMLRFKDEYKSENIKLREENEKLRLENSSLFSQALKDEEAKV 176
++ LE+ +L + + L+ + + L E +K+ + L+ L +E+ +
Sbjct: 3229 RDKEELEDLKFSLESQKQRNLQLNLLLEQQKQLLNESQQKIESQRM-LYDAQLSEEQGRN 3287
Query: 177 LQLTVRCEA-------LTGELETLKERCAQDACQ---AQAR-----EKELLELQSQQACT 221
L+L V E+ ++ L+ +E AQ Q+R E L ELQ Q
Sbjct: 3288 LELQVLLESEKVRIREMSSTLDRERELHAQLQSSDGTGQSRPPLPSEDLLKELQKQLEEK 3347
Query: 222 HTK------ETE-------QLRSQLQTLKQQHQQAVEQIAKAEETHSSLSQELQARLQTV 268
H++ ETE Q R Q++ +Q H++ ++ +A ELQ++++ +
Sbjct: 3348 HSRIVELLNETEKYKLDSLQTRQQMEKDRQVHRKTLQTEQEANTEGQKKMHELQSKVEDL 3407
Query: 269 TREKEE----LLQLSIERGKVLQNKQAEICQLEEKLEIANEDRKHALERFEQEAVAVDSN 324
R+ EE + +L +E G+ LQ E + E + E E R+ + + ++
Sbjct: 3408 QRQLEEKRQQVYKLDLE-GQRLQGIMQEFQKQELEREEKRESRRILYQNLNEPTTWSLTS 3466
Query: 325 LRVRE--LQRKVDGIQKAYDELRL 346
R R LQ+K++G K + +L
Sbjct: 3467 DRTRNWVLQQKIEGETKESNYAKL 3490
Score = 51.2 bits (121), Expect = 1e-06
Identities = 82/369 (22%), Positives = 160/369 (43%), Gaps = 37/369 (10%)
Query: 20 EERLEKQNEKLNNQEEETEFKELDGLREALA--NLRGLSEEERSEKAMLRSRIEEQSQLI 77
+E+L++ ++ N + E+ EF+ + L +AL + + E + L +++ + I
Sbjct: 2132 KEQLQRDIQERNEEIEKLEFRVRE-LEQALLVEDRKHFGAVEAKPELSLEVQLQAERDAI 2190
Query: 78 CILKRRSDEALERCQILELLNAELEEKMMQEAEKLKAQGEYSRKLEE-RFMTLAANHELM 136
R+ E + LE ELE K +E ++L Q E +K R L ++L
Sbjct: 2191 ---DRKEKEITNLEEQLEQFREELENKN-EEVQQLHMQLEIQKKESTTRLQELEQENKL- 2245
Query: 137 LRFKDEYKSENIKLREENEKLRLENSSLF---SQALKDEEAKVLQLTVRCEALTGELETL 193
FKD+ + + ++E + + LF +Q ++++E ++ QL + L +L+
Sbjct: 2246 --FKDDMEKLGLAIKESDAMSTQDQHVLFGKFAQIIQEKEVEIDQLNEQVTKLQQQLKIT 2303
Query: 194 KERCAQDACQAQAR--EKELLELQSQQAC---THTKETEQLRSQLQTLKQQHQQAVEQIA 248
+ + R E ++ L S Q C +E EQL ++ L+Q+ ++ +
Sbjct: 2304 TDNKVIEEKNELIRDLETQIECLMSDQECVKRNREEEIEQLNEVIEKLQQELANIGQKTS 2363
Query: 249 KAEETHSSLSQELQARLQTVTREK---EELLQLSIER----GKVLQNKQAEICQLEEKLE 301
+ S + L+ +L V EK E+ ++ + E VL+ ++ QL ++L
Sbjct: 2364 MNAHSLSEEADSLKHQLDVVIAEKLALEQQVETANEEMTFMKNVLKETNFKMNQLTQEL- 2422
Query: 302 IANEDRKHALERFEQEAVAVDSNLRVRELQRKVDGIQKAYDELR--LQSEAFKKHSLDLL 359
+L+R E+E+V ++ + +D + K EL L +A K
Sbjct: 2423 -------FSLKR-ERESVEKIQSIPENSVNVAIDHLSKDKPELEVVLTEDALKSLENQTY 2474
Query: 360 SKERELNGK 368
K E NGK
Sbjct: 2475 FKSFEENGK 2483
Score = 50.8 bits (120), Expect = 2e-06
Identities = 61/303 (20%), Positives = 136/303 (44%), Gaps = 25/303 (8%)
Query: 94 LELLNAELEE-KMMQEAEKLKAQGEYSRKLEER---FMTLAANHELMLRFKDEYKSENIK 149
+E LN ELEE ++ E L+ E+ +++R L AN + R KDE E ++
Sbjct: 171 IEELNRELEEMRVTYGTEGLQQLQEFEAAIKQRDGIITQLTANLQQARREKDETMREFLE 230
Query: 150 LREENEKLRLENSSL-FSQALKD--EEAKVLQLTVRCEALTGELETLKERCAQDACQAQA 206
L E+++KL+++ L S+ L++ + L + + + L+E+ +
Sbjct: 231 LTEQSQKLQIQFQQLQASETLRNSTHSSTAADLLQAKQQILTHQQQLEEQDHLLEDYQKK 290
Query: 207 REKELLELQSQQACTHTKETEQLRSQLQTLKQQHQQ---AVEQIAKAEETHSSLSQELQA 263
+E +++ Q E EQ + + K++ Q+ +E++ + EL+
Sbjct: 291 KEDFTMQISFLQEKIKVYEMEQDKKVENSNKEEIQEKETIIEELNTKIIEEEKKTLELKD 350
Query: 264 RLQTVTREKEELLQLSIERGKVLQNKQAEICQLEEKLEIANEDRKHALERFE--QEAVAV 321
+L T + EL + +++ + ++N + E+ ++K ++E+ K + E Q+
Sbjct: 351 KLTTADKLLGELQEQIVQKNQEIKNMKLELTNSKQKERQSSEEIKQLMGTVEELQKRNHK 410
Query: 322 DSNLRV-------RELQRKVDGIQKAYDEL------RLQSEAFKKHSLDLLSKERELNGK 368
DS +E QRK++ ++ DE+ +++ E ++H + + G+
Sbjct: 411 DSQFETDIVQRMEQETQRKLEQLRAELDEMYGQQIVQMKQELIRQHMAQMEEMKTRHKGE 470
Query: 369 LRH 371
+ +
Sbjct: 471 MEN 473
Score = 50.1 bits (118), Expect = 3e-06
Identities = 75/325 (23%), Positives = 134/325 (41%), Gaps = 40/325 (12%)
Query: 23 LEKQNEKLNNQEEETEFKELDGLREALANLRGLSEEERSEKAMLRSRIEEQSQLI--CIL 80
LEK+ KL EE + +EL+ L+ +L E ++ L +E+Q QL+
Sbjct: 3216 LEKEKAKLGRSEERDK-EELEDLKFSL-------ESQKQRNLQLNLLLEQQKQLLNESQQ 3267
Query: 81 KRRSDEALERCQILELLNAELEEKMMQEAEKLKAQGEYSRKLEERFMTL----------- 129
K S L Q+ E LE +++ E+EK++ + S ER +
Sbjct: 3268 KIESQRMLYDAQLSEEQGRNLELQVLLESEKVRIREMSSTLDRERELHAQLQSSDGTGQS 3327
Query: 130 ---AANHELMLRFK---DEYKSENIKLREENEKLRLENSSLFSQALKDEEAKVLQLTVRC 183
+ +L+ + +E S ++L E EK +L++ Q KD + L
Sbjct: 3328 RPPLPSEDLLKELQKQLEEKHSRIVELLNETEKYKLDSLQTRQQMEKDRQVHRKTLQTEQ 3387
Query: 184 EALT-GELETLKERCAQDACQAQAREKELLELQSQQACTHTKETEQLRSQLQTLKQQHQQ 242
EA T G+ + + + + Q Q EK QQ E ++L+ +Q ++Q +
Sbjct: 3388 EANTEGQKKMHELQSKVEDLQRQLEEKR------QQVYKLDLEGQRLQGIMQEFQKQELE 3441
Query: 243 AVEQIAKAEETHSSLSQELQARLQTVTREKEELLQLSIERGKVLQNKQAEICQLEEKLEI 302
E+ + +L++ L T R + +LQ IE G+ ++ A++ ++
Sbjct: 3442 REEKRESRRILYQNLNEPTTWSL-TSDRTRNWVLQQKIE-GETKESNYAKLIEMNG---- 3495
Query: 303 ANEDRKHALERFEQEAVAVDSNLRV 327
H LE Q+ V S L+V
Sbjct: 3496 GGTGCNHELEMIRQKLQCVASKLQV 3520
Score = 44.3 bits (103), Expect = 2e-04
Identities = 67/318 (21%), Positives = 131/318 (41%), Gaps = 33/318 (10%)
Query: 40 KELDGLREALANLRGLSEEERSEKAMLRSRIEEQ--SQLICILKRRSDEALERCQILELL 97
K +DG E G+ EE K +L + +EQ ++ ++ S ++ ++ +
Sbjct: 1408 KNIDGTIEFSGEF-GVKEETNIVK-LLEKQYQEQLEEEVAKVIVSMSIAFAQQTELSRIS 1465
Query: 98 NAELEEKMMQEAEKLKAQGEY---SRKLEERFMTLAANHELMLRFKDEYKSENIKLREEN 154
+ ++A + Q ++ KL + + + ++FK+E+K + +L E
Sbjct: 1466 GGKENTASSKQAHAVCQQEQHYFNEMKLSQDQIGFQTFETVDVKFKEEFKPLSKELGEHG 1525
Query: 155 EKLRLENSSLFSQALKDEEAKVLQLTVRCEALTGELETLKERCAQDACQAQAREKELLEL 214
+++ L NS E+K LT+ E + + + + D + +
Sbjct: 1526 KEILLSNSDPHDIP----ESKDCVLTISEEMFSKDKTFIVRQSIHDEISVSSMDA----- 1576
Query: 215 QSQQACTHTKETEQLRSQLQTLKQQHQQAVEQIAKAEETHSSLSQELQARLQ-TVTREKE 273
S+Q + ++ E +R +L Q+HQQA E + +A +E Q +LQ + R
Sbjct: 1577 -SRQLMLNEEQLEDMRQELVRQYQEHQQATELLRQAHMRQMERQREDQEQLQEEIKRLNR 1635
Query: 274 ELLQ--------LSIERGKVLQNKQAEICQL----EEKL--EIANEDRKHALERFEQEAV 319
+L Q L ER +VL + + QL EKL E+ N + E +
Sbjct: 1636 QLAQRSSIDNENLVSERERVLLEELEALKQLSLAGREKLCCELRNSSTQ-TQNGNENQGE 1694
Query: 320 AVDSNLRVRELQRKVDGI 337
+ + +EL RK + +
Sbjct: 1695 VEEQTFKEKELDRKPEDV 1712
Score = 38.5 bits (88), Expect = 0.010
Identities = 58/262 (22%), Positives = 120/262 (45%), Gaps = 40/262 (15%)
Query: 7 QKQQAPRMDTPPPEERLEKQNEKLNNQEEETEFKELDGLR-EALANLRGL-SEEERSEKA 64
++++ + +P E L+ E ++ EE F EL+ LR E++A L S +E++EK
Sbjct: 2648 KQREKEKKRSPQDVEVLKTTTELFHSNEESGFFNELEALRAESVATKAELASYKEKAEKL 2707
Query: 65 MLRSRIEE--QSQLICILKRRSDEALERCQILELLNAELEEKMMQEAEKLKAQGEYSRKL 122
++E + L L + D E + L +L E +E +QE++K KL
Sbjct: 2708 QEELLVKETNMTSLQKDLSQVRDHLAEAKEKLSILEKE-DETEVQESKKACMFEPLPIKL 2766
Query: 123 EERFMTLAANHELMLRFKDEYKSENIKLREENEKLRLENSSLFSQALKDEEAKVLQLTVR 182
+ ++A+ + L+ ++ I ++ ++ L+ S+ +E +++
Sbjct: 2767 SK---SIASQTDGTLKISSSNQTPQILVKNAGIQINLQ-----SECSSEEVTEIIS---- 2814
Query: 183 CEALTGELETLKERCAQDACQAQAREKELLELQSQQACTHTKETEQLRSQLQTLKQQHQQ 242
T ++E ++E A E+L+++S+ H ETE TLK++H
Sbjct: 2815 --QFTEKIEKMQELHAA----------EILDMESR----HISETE-------TLKREHYV 2851
Query: 243 AVEQIAKAEETHSSLSQELQAR 264
AV+ + + T ++ Q L+++
Sbjct: 2852 AVQLLKEECGTLKAVIQCLRSK 2873
Score = 35.4 bits (80), Expect = 0.084
Identities = 27/141 (19%), Positives = 60/141 (42%), Gaps = 5/141 (3%)
Query: 212 LELQSQQACTHTKETEQLRSQLQTLKQQHQ----QAVEQIAKAEETHSSLSQELQARLQT 267
LE+ + E E+L +L+ ++ + Q +++ A + + +L A LQ
Sbjct: 157 LEMMESELAGKQHEIEELNRELEEMRVTYGTEGLQQLQEFEAAIKQRDGIITQLTANLQQ 216
Query: 268 VTREKEELLQLSIERGKVLQNKQAEICQLEEKLEIANEDRKH-ALERFEQEAVAVDSNLR 326
REK+E ++ +E + Q Q + QL+ + N A + + + + +
Sbjct: 217 ARREKDETMREFLELTEQSQKLQIQFQQLQASETLRNSTHSSTAADLLQAKQQILTHQQQ 276
Query: 327 VRELQRKVDGIQKAYDELRLQ 347
+ E ++ QK ++ +Q
Sbjct: 277 LEEQDHLLEDYQKKKEDFTMQ 297
Score = 31.6 bits (70), Expect = 1.2
Identities = 59/314 (18%), Positives = 124/314 (39%), Gaps = 61/314 (19%)
Query: 4 PMLQKQQAPRMDTPPPEERLEKQNEKLNNQEEETEFK--------------ELDGLREAL 49
P + K+ + R P ++L+K+ L +++ + + +D +RE +
Sbjct: 1076 PSVTKESSLRATQPSENDKLQKELNVLKSEQNDLRLQMEAQRICLSLVYSTHVDQVREYM 1135
Query: 50 ANLRGLSEEERSEKAMLRSRIEEQSQLICILKR---------RSDEALERCQILELLNAE 100
N E++++ ++ I Q + I L++ ++ E + + L LL +
Sbjct: 1136 EN-----EKDKALCSLKEELIFAQEEKIKELQKIHQLELQTMKTQETGDEGKPLHLLIGK 1190
Query: 101 LEEKMMQEAEKL-----KAQGEYSRKLEERFMTLAANHELMLRFKD---EYKSENIKLRE 152
L++ + +E GEY T A E+ K+ +Y SEN
Sbjct: 1191 LQKAVSEECSYFLQTLCSVLGEY--------YTPALKCEVNAEDKENSGDYISENEDPEL 1242
Query: 153 ENEKLRL----ENSSLFSQALKDEEAKVLQLTVRCEALTGE------LETLKERCAQDAC 202
++ + + EN + +E K+L L R + G+ LE +E ++
Sbjct: 1243 QDYRYEVQDFQENMHTLLNKVTEEYNKLLVLQTRLSKIWGQQTDGMKLEFGEENLPKEET 1302
Query: 203 QAQAREKELLELQ-------SQQACTHTKETEQLRSQLQTLKQQHQQAVEQIAKAEETHS 255
+ + ++ L+ S+ + E +L Q+Q L+ +Q+ + E+ +
Sbjct: 1303 EFLSIHSQMTNLEDIDVNHKSKLSSLQDLEKTKLEEQVQELESLISSLQQQLKETEQNYE 1362
Query: 256 SLSQELQARLQTVT 269
+ LQ RLQ V+
Sbjct: 1363 AEIHCLQKRLQAVS 1376
>gi|59806361 hypothetical protein LOC387104 [Homo sapiens]
Length = 947
Score = 71.2 bits (173), Expect = 1e-12
Identities = 80/362 (22%), Positives = 159/362 (43%), Gaps = 56/362 (15%)
Query: 33 QEEETEFKELDGLREALANLRGLSEEERSEKAMLRSRI-EEQSQLICILKRRSDEALERC 91
QE+E +E++ LRE L+ +E R+E +R EE + + ++ + A + C
Sbjct: 347 QEQEEMQEEMEKLREENETLKNEIDELRTEMDEMRDTFFEEDACQLQEMRHELERANKNC 406
Query: 92 QILELLNAELEEKMMQEAEKLKAQGEYSRKLEE-----RFMTLAANHELMLRFKDEYKSE 146
+IL+ + E K ++ A+ + GE R LE+ + +++ +HEL + + +
Sbjct: 407 RILQYRLRKAERKRLRYAQTGEIDGELLRSLEQDLKVAKDVSVRLHHEL-----ENVEEK 461
Query: 147 NIKLREENEKLRLENSSLFSQALKDEEAKVLQLTVRCEALTGELETLKERCAQDACQAQA 206
+ENEKLR +++++ + +AL ELE +KE + + +
Sbjct: 462 RTTTEDENEKLR---------------QQLIEVEIAKQALQNELEKMKELSLK---RRGS 503
Query: 207 REKELLELQSQQACTHTKETEQLRSQLQTLKQQHQQAVEQIAKAEETHSSLSQELQ---- 262
++ E ++QQ T ++ E L+ QLQ +K++ +++AK ++ ELQ
Sbjct: 504 KDLPKSEKKAQQTPTE-EDNEDLKCQLQFVKEEAALMRKKMAKIDKEKDRFEHELQKYRS 562
Query: 263 -------------ARLQTVTREKEELLQLSI--ERGKVLQNKQAEICQLEEKLEIANEDR 307
A TRE E L+L + E +L K E LE+ N
Sbjct: 563 FYGDLDSPLPKGEAGGPPSTREAELKLRLRLVEEEANILGRKIVE-------LEVENRGL 615
Query: 308 KHALERFEQEAVAVDSNLRVRELQRKVDGIQKAYDELRLQSEAFKKHSLDLLSKERELNG 367
K L+ + +N +RE + +++ + ++E +++ DL + + +
Sbjct: 616 KAELDDLRGDDFNGSANPLMREQSESLSELRQHLQLVEDETELLRRNVADLEEQNKRITA 675
Query: 368 KL 369
+L
Sbjct: 676 EL 677
Score = 47.4 bits (111), Expect = 2e-05
Identities = 57/239 (23%), Positives = 102/239 (42%), Gaps = 26/239 (10%)
Query: 133 HELMLRFKDEYKSENIKLREENEKLRLENSSLFSQALKDEEAKVLQLTVRCEALTGELET 192
H L+ ++E + E KLREENE L+ E L ++ + + + + + + ELE
Sbjct: 342 HPQQLQEQEEMQEEMEKLREENETLKNEIDELRTEMDEMRDTFFEEDACQLQEMRHELER 401
Query: 193 LKERCAQDACQAQAREKELLELQSQQACTHTKETEQLRSQLQTLK----------QQHQQ 242
+ C Q + R+ E L+ Q T + E LRS Q LK + +
Sbjct: 402 ANKNCR--ILQYRLRKAERKRLRYAQ--TGEIDGELLRSLEQDLKVAKDVSVRLHHELEN 457
Query: 243 AVEQIAKAEETHSSLSQ---ELQARLQTVTREKEELLQLSIERGKVLQNKQAEICQLEEK 299
E+ E+ + L Q E++ Q + E E++ +LS++R ++E +
Sbjct: 458 VEEKRTTTEDENEKLRQQLIEVEIAKQALQNELEKMKELSLKRRGSKDLPKSEKKAQQTP 517
Query: 300 LEIANEDRKHALERFEQEAVAVDSNLRVRELQRKVDGIQKAYDELRLQSEAFKKHSLDL 358
E NED K L+ ++EA +++K+ I K D + + ++ DL
Sbjct: 518 TEEDNEDLKCQLQFVKEEAAL---------MRKKMAKIDKEKDRFEHELQKYRSFYGDL 567
>gi|32698688 citron [Homo sapiens]
Length = 2027
Score = 71.2 bits (173), Expect = 1e-12
Identities = 88/366 (24%), Positives = 166/366 (45%), Gaps = 53/366 (14%)
Query: 20 EERLEKQNEKLNNQEEETEFKELDGLREALANLRGLSEEERSEKAMLRSRIEEQSQLICI 79
+ER E++ EKL N+E+ +E G+R+ L L E+ R + L
Sbjct: 666 KERAERELEKLQNREDSSE-----GIRKKLVEAEELEEKHREAQV-------SAQHLEVH 713
Query: 80 LKRRSDEALERCQIL------ELLNAELEEKMMQEAEKLKAQGEYSRKLEERFMTLAANH 133
LK++ E+ ++L +L + E E MMQ E+ + E+ L+
Sbjct: 714 LKQKEQHYEEKIKVLDNQIKKDLADKETLENMMQRHEE---------EAHEKGKILSEQK 764
Query: 134 ELMLRFKDEYKSENIKLREENEKLRL-ENSSLFSQA-LKDEEAKVLQLTVR---CEALTG 188
++ + +S ++ E +E +L NSSLF+Q +K +E + +L + E G
Sbjct: 765 AMINAMDSKIRSLEQRIVELSEANKLAANSSLFTQRNMKAQEEMISELRQQKFYLETQAG 824
Query: 189 ELET----LKERCAQDACQAQAREKELLELQS---QQACTHTKETEQLRSQLQTLKQQHQ 241
+LE L+E+ + + Q + + LLEL++ + + H ++ +L+ QL L+ Q
Sbjct: 825 KLEAQNRKLEEQLEKISHQDHSDKNRLLELETRLREVSLEHEEQKLELKRQLTELQLSLQ 884
Query: 242 QAVEQIAKAEETHSSLSQEL---QARLQTVTREKEELLQ-LSIERGKV------LQNKQA 291
+ Q+ + ++L +L + L+ T E EE +Q L+ R ++ L+N
Sbjct: 885 ERESQLTALQAARAALESQLRQAKTELEETTAEAEEEIQALTAHRDEIQRKFDALRNSCT 944
Query: 292 EICQLEEKLEIANEDRKHALER----FEQEAVAVDSNLRVRELQRKVDGIQKAYDELRLQ 347
I LEE+L ED + +Q A +N + +L+ +VD +++ E +Q
Sbjct: 945 VITDLEEQLNQLTEDNAELNNQNFYLSKQLDEASGANDEIVQLRSEVDHLRREITEREMQ 1004
Query: 348 SEAFKK 353
+ K+
Sbjct: 1005 LTSQKQ 1010
Score = 55.8 bits (133), Expect = 6e-08
Identities = 82/363 (22%), Positives = 148/363 (40%), Gaps = 45/363 (12%)
Query: 22 RLEKQNEKLNNQEE--ETEFKELDGLREALANLRGLSEEERSEKAMLRSRIEEQSQLICI 79
+L + N +LNNQ + E G + + LR + R E ++ Q Q +
Sbjct: 955 QLTEDNAELNNQNFYLSKQLDEASGANDEIVQLRSEVDHLRREITEREMQLTSQKQTMEA 1014
Query: 80 LKRRSDEALERCQILELLNAELEEKMMQEAEKLKAQGEYSRKLEERFMTL---------- 129
LK E+ LE LN EL EK Q G+ + E R L
Sbjct: 1015 LKTTCTMLEEQVMDLEALNDELLEKERQWEAWRSVLGDEKSQFECRVRELQRMLDTEKQS 1074
Query: 130 --------AANHELMLRFKDEYKSENIKLREENEKLRLENSSLFSQALKDEEAKVLQLTV 181
+ +++ E+K+E + L++ ++ +L+ SL S L D E K L +
Sbjct: 1075 RARADQRITESRQVVELAVKEHKAEILALQQALKEQKLKAESL-SDKLNDLEKKHAMLEM 1133
Query: 182 RCEALTGELETLKERCAQDACQAQAREKELLELQSQQACTHTKETEQLRSQLQTLKQQHQ 241
+L +LET +E Q + QA+ ++ ++LQ ++ + L Q Q
Sbjct: 1134 NARSLQQKLETERE-LKQRLLEEQAKLQQQMDLQ--------------KNHIFRLTQGLQ 1178
Query: 242 QAVEQIAKAEETHSSLSQELQARLQTVTREKEELLQLSIERGKVLQNKQAEICQLEEKLE 301
+A+++ + S L +L+ + EK ++ ++ K++ QA++ Q +K +
Sbjct: 1179 EALDRADLLKTERSDLEYQLENIQVLYSHEKVKMEGTISQQTKLIDFLQAKMDQPAKKKK 1238
Query: 302 IANEDRKHALERFEQEAVAVDSNLRVRELQRKVDGIQKAYDELRLQSEAFKKHSLDLLSK 361
RK E A+ L+ EL+ ++ + EL EA +K ++L S
Sbjct: 1239 GLFSRRK------EDPALPTQVPLQYNELKLALEKEKARCAEL---EEALQKTRIELRSA 1289
Query: 362 ERE 364
E
Sbjct: 1290 REE 1292
Score = 49.3 bits (116), Expect = 6e-06
Identities = 64/265 (24%), Positives = 123/265 (46%), Gaps = 43/265 (16%)
Query: 2 RAPMLQKQQAPRMDTPPPEERL--EKQNEKLNNQEEETEFKELDG--LREALANLRGLSE 57
+A +L QQA + E++L E ++KLN+ E++ E++ L++ L R L +
Sbjct: 1097 KAEILALQQALK------EQKLKAESLSDKLNDLEKKHAMLEMNARSLQQKLETERELKQ 1150
Query: 58 EERSEKAMLRSRIEEQSQLICILKRRSDEALERCQILELLNAELEEKM-----MQEAEKL 112
E+A L+ +++ Q I L + EAL+R +L+ ++LE ++ + EK+
Sbjct: 1151 RLLEEQAKLQQQMDLQKNHIFRLTQGLQEALDRADLLKTERSDLEYQLENIQVLYSHEKV 1210
Query: 113 KAQGEYSRKLEERFMTLAANHELMLRFKDEYKSENIKLREENEKLRLENSSLFSQALKDE 172
K +G S++ + ++ F L+ + ++ + LFS+ K++
Sbjct: 1211 KMEGTISQQTK------------LIDF----------LQAKMDQPAKKKKGLFSRR-KED 1247
Query: 173 EAKVLQLTVRCEALTGELETLKERCAQDACQAQAREKELLELQS-QQACTHTKETEQLRS 231
A Q+ ++ L LE K RCA+ +A +K +EL+S ++ H K T+
Sbjct: 1248 PALPTQVPLQYNELKLALEKEKARCAE---LEEALQKTRIELRSAREEAAHRKATDHPHP 1304
Query: 232 QLQTLKQQHQQAVEQIAKAEETHSS 256
+Q Q A+ I ++ E S
Sbjct: 1305 STPATARQ-QIAMSAIVRSPEHQPS 1328
Score = 36.6 bits (83), Expect = 0.038
Identities = 39/188 (20%), Positives = 87/188 (46%), Gaps = 19/188 (10%)
Query: 182 RCEALTGELETLKERCAQDACQAQAREKELLELQSQQACTHTKETEQLRSQLQTLKQQHQ 241
+C + E+ L R ++ +E EL ++Q++ ++ ++ +LK+ +
Sbjct: 464 KCHKMEQEMTRLHRRVSEVEAVLSQKEVELKASETQRSLLE-QDLATYITECSSLKRSLE 522
Query: 242 QAVEQIAKAEETHSSLSQELQARLQTVTREKEELLQLSIERGKVLQNKQAEICQLEEKLE 301
QA ++++ ++ L +++ + + + KE+ Q +E +++ N QLEE L
Sbjct: 523 QARMEVSQEDDKALQLLHDIREQSRKLQEIKEQEYQAQVEEMRLMMN------QLEEDLV 576
Query: 302 IANEDRKHALERFEQEAVAVDSNLRVRELQRKVDGIQ----KAYDELRLQSEAFKKHSLD 357
A + + +E E +S L E +RK Q KA D+ + + + K L+
Sbjct: 577 SA----RRRSDLYESE--LRESRLAAEEFKRKATECQHKLLKAKDQGKPEVGEYAK--LE 628
Query: 358 LLSKEREL 365
++ E++L
Sbjct: 629 KINAEQQL 636
>gi|22538387 A-kinase anchor protein 9 isoform 2 [Homo sapiens]
Length = 3907
Score = 70.9 bits (172), Expect = 2e-12
Identities = 96/426 (22%), Positives = 173/426 (40%), Gaps = 69/426 (16%)
Query: 1 MRAPMLQKQQAPRMDTPPPEERLEKQNEKLNNQEEETEFKELDGLREALANLRGLSEEER 60
MR QKQ+A E R E ++ E + +G+ + A+ + L E +
Sbjct: 1879 MRESFRQKQEATESLKCQEELRERLHEESRAREQLAVELSKAEGVIDGYADEKTLFERQI 1938
Query: 61 SEKAMLRSRIEEQSQLICILKRRSDEALERCQILE----------LLNAE---LEEKMMQ 107
EK + R+E++ L+C R + E+ QI E + AE +E++++Q
Sbjct: 1939 QEKTDIIDRLEQE--LLCASNRLQELEAEQQQIQEERELLSRQKEAMKAEAGPVEQQLLQ 1996
Query: 108 EAEKL------------KAQGEYSRKLEERFMTLAANHELMLRFKDEYKSENIKLREENE 155
E EKL K + + ++++ + + + + E +E + LR++N+
Sbjct: 1997 ETEKLMKEKLEVQCQAEKVRDDLQKQVKALEIDVEEQVSRFIELEQEKNTELMDLRQQNQ 2056
Query: 156 KL--RLENSSLF--SQAL-KDEEAKVLQLTVR---------------CEALTGELETLKE 195
L +LE F QA+ ++ E V Q ++ E T E+E L
Sbjct: 2057 ALEKQLEKMRKFLDEQAIDREHERDVFQQEIQKLEQQLKVVPRFQPISEHQTREVEQLAN 2116
Query: 196 RCAQ--DACQAQAREKELLELQSQQACTHTKETEQLRSQLQTLKQQHQQAVEQIAKAEET 253
+ D C KE L+ Q+ +E E+L +++ L+Q + + K E+
Sbjct: 2117 HLKEKTDKCSELLLSKEQLQRDIQE---RNEEIEKLEFRVRELEQALLVSADTFQKVEDR 2173
Query: 254 HS----------SLSQELQARLQTVTREKEELLQLSIERGKV---LQNKQAEICQLEEKL 300
SL +LQA + R+++E+ L + + L+NK E+ QL +L
Sbjct: 2174 KHFGAVEAKPELSLEVQLQAERDAIDRKEKEITNLEEQLEQFREELENKNEEVQQLHMQL 2233
Query: 301 EIANEDRKHALERFEQEAVAVDSNLRVRELQRKVDGIQKAYDELRLQSEAFKKHSLDLLS 360
EI ++ L+ EQE ++ L K D Q F K + +
Sbjct: 2234 EIQKKESTTRLQELEQENKLFKDDMEKLGLAIKESDAMSTQD----QHVLFGKFAQIIQE 2289
Query: 361 KERELN 366
KE E++
Sbjct: 2290 KEVEID 2295
Score = 62.8 bits (151), Expect = 5e-10
Identities = 79/356 (22%), Positives = 155/356 (43%), Gaps = 32/356 (8%)
Query: 7 QKQQAPRMDTPPPEERLEKQN--EKLNNQEEETEFKELDGLREALANLRGLSEEERSEKA 64
+ +Q +++ EE EK+ E+LN + E E K L+ L++ L L E + +
Sbjct: 309 EMEQDKKVENSNKEEIQEKETIIEELNTKIIEEEKKTLE-LKDKLTTADKLLGELQEQIV 367
Query: 65 MLRSRIEEQSQLICILKRRSDEALERCQILELLNAELEEKMMQEAE-----KLKAQGEYS 119
I+ + K++ ++ E + L EL+++ ++++ + + E
Sbjct: 368 QKNQEIKNMKLELTNSKQKERQSSEEIKQLMGTVEELQKRNHKDSQFETDIVQRMEQETQ 427
Query: 120 RKLEERFMTLAANH-ELMLRFKDEYKSENIKLREE---NEKLRLENSSLFSQALKDEEAK 175
RKLE+ L + + +++ K E +++ EE K +EN+ + E +
Sbjct: 428 RKLEQLRAELDEMYGQQIVQMKQELIRQHMAQMEEMKTRHKGEMENALRSYSNITVNEDQ 487
Query: 176 VLQLTVRCEALTGELETLKERCAQDACQAQAREKELLELQSQQACTHTKETEQLRSQLQT 235
+ + V L +L QD + + KE L L ++ C ++ E L +L
Sbjct: 488 IKLMNVAINELNIKL--------QDTNSQKEKLKEELGLILEEKCALQRQLEDLVEELSF 539
Query: 236 LKQQHQQA----VEQIAKAEETHSSLSQELQARLQTVTREKEELLQLSIERGKVLQNKQA 291
++Q Q+A EQ +K E H SLS TV K E++ S R ++ +A
Sbjct: 540 SREQIQRARQTIAEQESKLNEAHKSLS--------TVEDLKAEIVSASESRKELELKHEA 591
Query: 292 EICQLEEKLEIANEDRKHALERFEQEAVAVDSNLRVRELQRKVDGIQKAYDELRLQ 347
E+ + KLE+ +++ L+R + A LR + L + + K ++L ++
Sbjct: 592 EVTNYKIKLEMLEKEKNAVLDRMAESQEAELERLRTQLLFSHEEELSKLKEDLEIE 647
Score = 58.9 bits (141), Expect = 7e-09
Identities = 73/369 (19%), Positives = 161/369 (43%), Gaps = 61/369 (16%)
Query: 6 LQKQQAPRMDTPPPEERLEKQNEKLNNQEEETEFKELDGLREALANLRGLSEEERSEKAM 65
L +Q +M+ + E +N + ++ + A+ L ++ S+K
Sbjct: 452 LIRQHMAQMEEMKTRHKGEMENALRSYSNITVNEDQIKLMNVAINELNIKLQDTNSQKEK 511
Query: 66 LRSRIEEQSQLICILKRRSDEALERCQILELLNAELEEKMMQEAEKLKAQGEYSRKLEER 125
L+ + + C L+R+ ++ +E + +Q A + A+ E KL E
Sbjct: 512 LKEELGLILEEKCALQRQLEDLVE--------ELSFSREQIQRARQTIAEQE--SKLNEA 561
Query: 126 FMTLAANHELMLRFKDEYKSENIKLREENEKLRLENSSLFSQALKDEEAKVLQLTVRCEA 185
+L+ +L K+E + E ++L L++ EA+V ++ E
Sbjct: 562 HKSLSTVEDL--------KAEIVSASESRKELELKH-----------EAEVTNYKIKLEM 602
Query: 186 LTGELETLKERCAQDACQAQAREKELLELQSQQACTHTKETEQLRSQLQTLKQQHQQAVE 245
L E + +R A+++E EL L++Q +H +E +L+ L+ +H+ +E
Sbjct: 603 LEKEKNAVLDR------MAESQEAELERLRTQLLFSHEEELSKLKEDLEI---EHRINIE 653
Query: 246 QIAKAEETH-----SSLSQELQARLQTVTREKEELL----QLSIERGKVLQNKQA----- 291
++ H L E+ +++T+ EK+ L+ QL +E K+ +Q+
Sbjct: 654 KLKDNLGIHYKQQIDGLQNEMSQKIETMQFEKDNLITKQNQLILEISKLKDLQQSLVNSK 713
Query: 292 ------EICQLEEKLEIANEDRKH--ALERFEQEAVAVDSNLRVRELQRKVDGIQKAYDE 343
+I +L++++EI ++ K LE+ QE + + + L ++++ K + +Q+ + +
Sbjct: 714 SEEMTLQINELQKEIEILRQEEKEKGTLEQEVQE-LQLKTELLEKQMKEKENDLQEKFAQ 772
Query: 344 LRLQSEAFK 352
L ++ K
Sbjct: 773 LEAENSILK 781
Score = 57.0 bits (136), Expect = 3e-08
Identities = 91/376 (24%), Positives = 166/376 (44%), Gaps = 35/376 (9%)
Query: 21 ERLEKQNEKLNNQEEETEFKELDGLREAL--ANLRGLSEEERSEKAMLRSRIEEQSQLIC 78
E LEK+ + ++ E++ EL+ LR L ++ LS+ + + R IE+ +
Sbjct: 601 EMLEKEKNAVLDRMAESQEAELERLRTQLLFSHEEELSKLKEDLEIEHRINIEKLKDNLG 660
Query: 79 ILKRRSDEAL--ERCQILELLNAELEE------KMMQEAEKLK--AQGEYSRKLEERFMT 128
I ++ + L E Q +E + E + +++ E KLK Q + K EE MT
Sbjct: 661 IHYKQQIDGLQNEMSQKIETMQFEKDNLITKQNQLILEISKLKDLQQSLVNSKSEE--MT 718
Query: 129 LAANH-ELMLRFKDEYKSENIKLREENEKLRLENSSLFSQALKDE---EAKVLQLTVRCE 184
L N + + + + E L +E ++L+L+ L Q + E + K QL
Sbjct: 719 LQINELQKEIEILRQEEKEKGTLEQEVQELQLKTELLEKQMKEKENDLQEKFAQLEAENS 778
Query: 185 ALTGELETLKERCAQDACQAQAREKELLELQSQQACTHT----KETEQLRSQLQTLKQQH 240
L E +TL++ +Q E+ L+ L S ++ + KE E L + + LKQQ
Sbjct: 779 ILKDEKKTLEDMLKIHTPVSQ--EERLIFLDSIKSKSKDSVWEKEIEILIEENEDLKQQC 836
Query: 241 QQAVEQIAKAEETHSSLSQELQARLQTVTREKEELLQLSIERGKVLQNKQAEICQLEEKL 300
Q E+I K T S + + Q + E LL++ + + +K + + + KL
Sbjct: 837 IQLNEEIEKQRNTFSFAEKNFEVNYQELQEEYACLLKV---KDDLEDSKNKQELEYKSKL 893
Query: 301 EIANEDRKHALERFEQEAVAVDSNL------RVRELQRKVDGIQKAYDELRLQSEAFKKH 354
+ NE+ L+R V + S++ V E + ++K EL + E K+
Sbjct: 894 KALNEELH--LQRINPTTVKMKSSVFDEDKTFVAETLEMGEVVEKDTTELMEKLEVTKRE 951
Query: 355 SLDLLSKERELNGKLR 370
L+L + +L+ +L+
Sbjct: 952 KLELSQRLSDLSEQLK 967
Score = 57.0 bits (136), Expect = 3e-08
Identities = 79/322 (24%), Positives = 151/322 (46%), Gaps = 50/322 (15%)
Query: 70 IEEQSQLICILKRRSDEALERCQILELLNAELEEKMMQEAEKLKAQGEYSRKLEERFMT- 128
+EE+S L+ R AL + LLN LE+++ ++ + +A E +K + R +
Sbjct: 3035 LEERSVLLAAF-RTELTALGTTDAVGLLNC-LEQRIQEQGVEYQAAMECLQKADRRSLLS 3092
Query: 129 -LAANHELMLRFKDEYKSENIKLREENEKLRLENSSLFSQALKDEEAKVLQLTVRCEALT 187
+ A H M K K E +E+EK + L ++ +++++L++ V
Sbjct: 3093 EIQALHAQMNGRKITLKRE-----QESEK---PSQELLEYNIQQKQSQMLEMQV------ 3138
Query: 188 GELETLKERCAQDACQAQAREKELLELQSQQACTHTKETEQLRSQLQTLKQQHQQAVEQI 247
EL ++K+R + Q + + + EL+S+ A T + L++Q + LK+ +E
Sbjct: 3139 -ELSSMKDRATELQEQLSSEKMVVAELKSELAQTKLELETTLKAQHKHLKELEAFRLEVK 3197
Query: 248 AKAEETHSSLSQELQARLQTVTREKEELLQLSIERGKVLQNKQAEICQLEEKLEIANEDR 307
K +E H L + A Q +RE LQ ++E+ K A++ + EE+ + ED
Sbjct: 3198 DKTDEVH--LLNDTLASEQKKSRE----LQWALEKEK------AKLGRSEERDKEELEDL 3245
Query: 308 KHALERFEQEAVAVDSNLR-----VRELQRKVDGIQKAYD-------------ELRLQSE 349
K +LE +Q + ++ L + E Q+K++ + YD ++ L+SE
Sbjct: 3246 KFSLESQKQRNLQLNLLLEQQKQLLNESQQKIESQRMLYDAQLSEEQGRNLELQVLLESE 3305
Query: 350 AFK-KHSLDLLSKERELNGKLR 370
+ + L +EREL+ +L+
Sbjct: 3306 KVRIREMSSTLDRERELHAQLQ 3327
Score = 53.9 bits (128), Expect = 2e-07
Identities = 87/374 (23%), Positives = 165/374 (44%), Gaps = 59/374 (15%)
Query: 20 EERLEKQN-------EKLNNQEEETEFKELDGLREAL----ANLRGLSEEERSEKAMLRS 68
E+R+++Q E L + + E+ L + L+ E E+ + +L
Sbjct: 3065 EQRIQEQGVEYQAAMECLQKADRRSLLSEIQALHAQMNGRKITLKREQESEKPSQELLEY 3124
Query: 69 RIEE-QSQLICI------LKRRSDEALERCQILELLNAELEEKMMQ---EAEK-LKAQGE 117
I++ QSQ++ + +K R+ E E+ +++ AEL+ ++ Q E E LKAQ +
Sbjct: 3125 NIQQKQSQMLEMQVELSSMKDRATELQEQLSSEKMVVAELKSELAQTKLELETTLKAQHK 3184
Query: 118 YSRKLEERFMTLAANHELMLRFKDEYKSENIKLREENEKLRLENSSLFSQALKDEEAKVL 177
+ ++LE + + + + D SE K RE L E + L +D+E
Sbjct: 3185 HLKELEAFRLEVKDKTDEVHLLNDTLASEQKKSRELQWALEKEKAKLGRSEERDKE---- 3240
Query: 178 QLTVRCEALTGELETLKERCAQDACQAQAREKELL-----ELQSQQACTHTKETEQL--R 230
E L LE+ K+R Q + ++K+LL +++SQ+ + +E+
Sbjct: 3241 ----ELEDLKFSLESQKQRNLQLNLLLE-QQKQLLNESQQKIESQRMLYDAQLSEEQGRN 3295
Query: 231 SQLQTLKQQHQQAVEQIAKAEETHSSLSQELQARLQTVTRE----KEELLQLSIERGKVL 286
+LQ L + + + +++ + L +LQ+ T E+LL+ E K L
Sbjct: 3296 LELQVLLESEKVRIREMSSTLDRERELHAQLQSSDGTGQSRPPLPSEDLLK---ELQKQL 3352
Query: 287 QNKQAEICQL---EEKLEIANEDRKHALER----------FEQEAVAVDSNLRVRELQRK 333
+ K + I +L EK ++ + + +E+ EQEA + ++ ELQ K
Sbjct: 3353 EEKHSRIVELLNETEKYKLDSLQTRQQMEKDRQVHRKTLQTEQEA-NTEGQKKMHELQSK 3411
Query: 334 VDGIQKAYDELRLQ 347
V+ +Q+ +E R Q
Sbjct: 3412 VEDLQRQLEEKRQQ 3425
Score = 53.1 bits (126), Expect = 4e-07
Identities = 84/392 (21%), Positives = 179/392 (45%), Gaps = 52/392 (13%)
Query: 5 MLQKQQAPRMDTPPPEERLEKQNEKLNNQEEETEFKELDGLREALANLRG----LSEEER 60
+L++++ + + L+ + E L Q +E E + L+E A L L +E++
Sbjct: 730 ILRQEEKEKGTLEQEVQELQLKTELLEKQMKEKE----NDLQEKFAQLEAENSILKDEKK 785
Query: 61 SEKAMLR--SRIEEQSQLICI--LKRRSDEAL--ERCQILELLNAELEEKMMQEAEKLKA 114
+ + ML+ + + ++ +LI + +K +S +++ + +IL N +L+++ +Q E+++
Sbjct: 786 TLEDMLKIHTPVSQEERLIFLDSIKSKSKDSVWEKEIEILIEENEDLKQQCIQLNEEIEK 845
Query: 115 QGEY----SRKLEERFMTLAANHELMLRFKDEYK-SENIKLREENEKLRLENSSLFSQAL 169
Q + E + L + +L+ KD+ + S+N + E KL+ N L Q +
Sbjct: 846 QRNTFSFAEKNFEVNYQELQEEYACLLKVKDDLEDSKNKQELEYKSKLKALNEELHLQRI 905
Query: 170 KDEEAKVLQLTVRCEALTGELETLK--ERCAQDACQAQAR----EKELLELQ------SQ 217
K ++ +V E T ETL+ E +D + + ++E LEL S+
Sbjct: 906 NPTTVK-MKSSVFDEDKTFVAETLEMGEVVEKDTTELMEKLEVTKREKLELSQRLSDLSE 964
Query: 218 QACTHTKETEQLRSQLQTLKQQHQQAVEQIAKAE--------ETHSSLSQELQARLQTVT 269
Q E L ++++LKQ+ +Q + + E E S ++ + L V
Sbjct: 965 QLKQKHGEISFLNEEVKSLKQEKEQVSLRCRELEIIINHNRAENVQSCDTQVSSLLDGVV 1024
Query: 270 REKEELLQLSIERGKVLQNKQAEICQLEEKLEIAN-----EDRKHALERFEQEAVAVDSN 324
+ S+ + ++++I +E+K+ N E ++ L +V +S+
Sbjct: 1025 TMTSRGAEGSVSKVNKSFGEESKI-MVEDKVSFENMTVGEESKQEQLILDHLPSVTKESS 1083
Query: 325 LRVRE------LQRKVDGIQKAYDELRLQSEA 350
LR + LQ++++ ++ ++LRLQ EA
Sbjct: 1084 LRATQPSENDKLQKELNVLKSEQNDLRLQMEA 1115
Score = 53.1 bits (126), Expect = 4e-07
Identities = 90/384 (23%), Positives = 168/384 (43%), Gaps = 57/384 (14%)
Query: 18 PPEERLE-----KQNEKLNNQEEETEFKE-LDGLREALANLRGLSEEERSEKAM----LR 67
P +E LE KQ++ L Q E + K+ L+E L++ + + E +SE A L
Sbjct: 3117 PSQELLEYNIQQKQSQMLEMQVELSSMKDRATELQEQLSSEKMVVAELKSELAQTKLELE 3176
Query: 68 SRIEEQSQLICILKRRSDEALERCQILELLN----------AELEEKMMQEAEKLKAQGE 117
+ ++ Q + + L+ E ++ + LLN EL+ + +E KL E
Sbjct: 3177 TTLKAQHKHLKELEAFRLEVKDKTDEVHLLNDTLASEQKKSRELQWALEKEKAKLGRSEE 3236
Query: 118 YSRK-LEERFMTLAANHELMLRFKDEYKSENIKLREENEKLRLENSSLFSQALKDEEAKV 176
++ LE+ +L + + L+ + + L E +K+ + L+ L +E+ +
Sbjct: 3237 RDKEELEDLKFSLESQKQRNLQLNLLLEQQKQLLNESQQKIESQRM-LYDAQLSEEQGRN 3295
Query: 177 LQLTVRCEA-------LTGELETLKERCAQDACQ---AQAR-----EKELLELQSQQACT 221
L+L V E+ ++ L+ +E AQ Q+R E L ELQ Q
Sbjct: 3296 LELQVLLESEKVRIREMSSTLDRERELHAQLQSSDGTGQSRPPLPSEDLLKELQKQLEEK 3355
Query: 222 HTK------ETE-------QLRSQLQTLKQQHQQAVEQIAKAEETHSSLSQELQARLQTV 268
H++ ETE Q R Q++ +Q H++ ++ +A ELQ++++ +
Sbjct: 3356 HSRIVELLNETEKYKLDSLQTRQQMEKDRQVHRKTLQTEQEANTEGQKKMHELQSKVEDL 3415
Query: 269 TREKEE----LLQLSIERGKVLQNKQAEICQLEEKLEIANEDRKHALERFEQEAVAVDSN 324
R+ EE + +L +E G+ LQ E + E + E E R+ + + ++
Sbjct: 3416 QRQLEEKRQQVYKLDLE-GQRLQGIMQEFQKQELEREEKRESRRILYQNLNEPTTWSLTS 3474
Query: 325 LRVRE--LQRKVDGIQKAYDELRL 346
R R LQ+K++G K + +L
Sbjct: 3475 DRTRNWVLQQKIEGETKESNYAKL 3498
Score = 50.8 bits (120), Expect = 2e-06
Identities = 61/303 (20%), Positives = 136/303 (44%), Gaps = 25/303 (8%)
Query: 94 LELLNAELEE-KMMQEAEKLKAQGEYSRKLEER---FMTLAANHELMLRFKDEYKSENIK 149
+E LN ELEE ++ E L+ E+ +++R L AN + R KDE E ++
Sbjct: 171 IEELNRELEEMRVTYGTEGLQQLQEFEAAIKQRDGIITQLTANLQQARREKDETMREFLE 230
Query: 150 LREENEKLRLENSSL-FSQALKD--EEAKVLQLTVRCEALTGELETLKERCAQDACQAQA 206
L E+++KL+++ L S+ L++ + L + + + L+E+ +
Sbjct: 231 LTEQSQKLQIQFQQLQASETLRNSTHSSTAADLLQAKQQILTHQQQLEEQDHLLEDYQKK 290
Query: 207 REKELLELQSQQACTHTKETEQLRSQLQTLKQQHQQ---AVEQIAKAEETHSSLSQELQA 263
+E +++ Q E EQ + + K++ Q+ +E++ + EL+
Sbjct: 291 KEDFTMQISFLQEKIKVYEMEQDKKVENSNKEEIQEKETIIEELNTKIIEEEKKTLELKD 350
Query: 264 RLQTVTREKEELLQLSIERGKVLQNKQAEICQLEEKLEIANEDRKHALERFE--QEAVAV 321
+L T + EL + +++ + ++N + E+ ++K ++E+ K + E Q+
Sbjct: 351 KLTTADKLLGELQEQIVQKNQEIKNMKLELTNSKQKERQSSEEIKQLMGTVEELQKRNHK 410
Query: 322 DSNLRV-------RELQRKVDGIQKAYDEL------RLQSEAFKKHSLDLLSKERELNGK 368
DS +E QRK++ ++ DE+ +++ E ++H + + G+
Sbjct: 411 DSQFETDIVQRMEQETQRKLEQLRAELDEMYGQQIVQMKQELIRQHMAQMEEMKTRHKGE 470
Query: 369 LRH 371
+ +
Sbjct: 471 MEN 473
Score = 50.1 bits (118), Expect = 3e-06
Identities = 75/325 (23%), Positives = 134/325 (41%), Gaps = 40/325 (12%)
Query: 23 LEKQNEKLNNQEEETEFKELDGLREALANLRGLSEEERSEKAMLRSRIEEQSQLI--CIL 80
LEK+ KL EE + +EL+ L+ +L E ++ L +E+Q QL+
Sbjct: 3224 LEKEKAKLGRSEERDK-EELEDLKFSL-------ESQKQRNLQLNLLLEQQKQLLNESQQ 3275
Query: 81 KRRSDEALERCQILELLNAELEEKMMQEAEKLKAQGEYSRKLEERFMTL----------- 129
K S L Q+ E LE +++ E+EK++ + S ER +
Sbjct: 3276 KIESQRMLYDAQLSEEQGRNLELQVLLESEKVRIREMSSTLDRERELHAQLQSSDGTGQS 3335
Query: 130 ---AANHELMLRFK---DEYKSENIKLREENEKLRLENSSLFSQALKDEEAKVLQLTVRC 183
+ +L+ + +E S ++L E EK +L++ Q KD + L
Sbjct: 3336 RPPLPSEDLLKELQKQLEEKHSRIVELLNETEKYKLDSLQTRQQMEKDRQVHRKTLQTEQ 3395
Query: 184 EALT-GELETLKERCAQDACQAQAREKELLELQSQQACTHTKETEQLRSQLQTLKQQHQQ 242
EA T G+ + + + + Q Q EK QQ E ++L+ +Q ++Q +
Sbjct: 3396 EANTEGQKKMHELQSKVEDLQRQLEEKR------QQVYKLDLEGQRLQGIMQEFQKQELE 3449
Query: 243 AVEQIAKAEETHSSLSQELQARLQTVTREKEELLQLSIERGKVLQNKQAEICQLEEKLEI 302
E+ + +L++ L T R + +LQ IE G+ ++ A++ ++
Sbjct: 3450 REEKRESRRILYQNLNEPTTWSL-TSDRTRNWVLQQKIE-GETKESNYAKLIEMNG---- 3503
Query: 303 ANEDRKHALERFEQEAVAVDSNLRV 327
H LE Q+ V S L+V
Sbjct: 3504 GGTGCNHELEMIRQKLQCVASKLQV 3528
Score = 49.3 bits (116), Expect = 6e-06
Identities = 84/374 (22%), Positives = 161/374 (43%), Gaps = 39/374 (10%)
Query: 20 EERLEKQNEKLNNQEEETEFK--ELDGLREALANLRGLSEEER-----SEKAMLRSRIEE 72
+E+L++ ++ N + E+ EF+ EL+ A+ E+ + K L ++
Sbjct: 2132 KEQLQRDIQERNEEIEKLEFRVRELEQALLVSADTFQKVEDRKHFGAVEAKPELSLEVQL 2191
Query: 73 QSQLICILKRRSDEALERCQILELLNAELEEKMMQEAEKLKAQGEYSRKLEE-RFMTLAA 131
Q++ I R+ E + LE ELE K +E ++L Q E +K R L
Sbjct: 2192 QAERDAI-DRKEKEITNLEEQLEQFREELENKN-EEVQQLHMQLEIQKKESTTRLQELEQ 2249
Query: 132 NHELMLRFKDEYKSENIKLREENEKLRLENSSLF---SQALKDEEAKVLQLTVRCEALTG 188
++L FKD+ + + ++E + + LF +Q ++++E ++ QL + L
Sbjct: 2250 ENKL---FKDDMEKLGLAIKESDAMSTQDQHVLFGKFAQIIQEKEVEIDQLNEQVTKLQQ 2306
Query: 189 ELETLKERCAQDACQAQAR--EKELLELQSQQAC---THTKETEQLRSQLQTLKQQHQQA 243
+L+ + + R E ++ L S Q C +E EQL ++ L+Q+
Sbjct: 2307 QLKITTDNKVIEEKNELIRDLETQIECLMSDQECVKRNREEEIEQLNEVIEKLQQELANI 2366
Query: 244 VEQIAKAEETHSSLSQELQARLQTVTREK---EELLQLSIER----GKVLQNKQAEICQL 296
++ + + S + L+ +L V EK E+ ++ + E VL+ ++ QL
Sbjct: 2367 GQKTSMNAHSLSEEADSLKHQLDVVIAEKLALEQQVETANEEMTFMKNVLKETNFKMNQL 2426
Query: 297 EEKLEIANEDRKHALERFEQEAVAVDSNLRVRELQRKVDGIQKAYDELR--LQSEAFKKH 354
++L +L+R E+E+V ++ + +D + K EL L +A K
Sbjct: 2427 TQEL--------FSLKR-ERESVEKIQSIPENSVNVAIDHLSKDKPELEVVLTEDALKSL 2477
Query: 355 SLDLLSKERELNGK 368
K E NGK
Sbjct: 2478 ENQTYFKSFEENGK 2491
Score = 44.3 bits (103), Expect = 2e-04
Identities = 67/318 (21%), Positives = 131/318 (41%), Gaps = 33/318 (10%)
Query: 40 KELDGLREALANLRGLSEEERSEKAMLRSRIEEQ--SQLICILKRRSDEALERCQILELL 97
K +DG E G+ EE K +L + +EQ ++ ++ S ++ ++ +
Sbjct: 1408 KNIDGTIEFSGEF-GVKEETNIVK-LLEKQYQEQLEEEVAKVIVSMSIAFAQQTELSRIS 1465
Query: 98 NAELEEKMMQEAEKLKAQGEY---SRKLEERFMTLAANHELMLRFKDEYKSENIKLREEN 154
+ ++A + Q ++ KL + + + ++FK+E+K + +L E
Sbjct: 1466 GGKENTASSKQAHAVCQQEQHYFNEMKLSQDQIGFQTFETVDVKFKEEFKPLSKELGEHG 1525
Query: 155 EKLRLENSSLFSQALKDEEAKVLQLTVRCEALTGELETLKERCAQDACQAQAREKELLEL 214
+++ L NS E+K LT+ E + + + + D + +
Sbjct: 1526 KEILLSNSDPHDIP----ESKDCVLTISEEMFSKDKTFIVRQSIHDEISVSSMDA----- 1576
Query: 215 QSQQACTHTKETEQLRSQLQTLKQQHQQAVEQIAKAEETHSSLSQELQARLQ-TVTREKE 273
S+Q + ++ E +R +L Q+HQQA E + +A +E Q +LQ + R
Sbjct: 1577 -SRQLMLNEEQLEDMRQELVRQYQEHQQATELLRQAHMRQMERQREDQEQLQEEIKRLNR 1635
Query: 274 ELLQ--------LSIERGKVLQNKQAEICQL----EEKL--EIANEDRKHALERFEQEAV 319
+L Q L ER +VL + + QL EKL E+ N + E +
Sbjct: 1636 QLAQRSSIDNENLVSERERVLLEELEALKQLSLAGREKLCCELRNSSTQ-TQNGNENQGE 1694
Query: 320 AVDSNLRVRELQRKVDGI 337
+ + +EL RK + +
Sbjct: 1695 VEEQTFKEKELDRKPEDV 1712
Score = 38.5 bits (88), Expect = 0.010
Identities = 58/262 (22%), Positives = 120/262 (45%), Gaps = 40/262 (15%)
Query: 7 QKQQAPRMDTPPPEERLEKQNEKLNNQEEETEFKELDGLR-EALANLRGL-SEEERSEKA 64
++++ + +P E L+ E ++ EE F EL+ LR E++A L S +E++EK
Sbjct: 2656 KQREKEKKRSPQDVEVLKTTTELFHSNEESGFFNELEALRAESVATKAELASYKEKAEKL 2715
Query: 65 MLRSRIEE--QSQLICILKRRSDEALERCQILELLNAELEEKMMQEAEKLKAQGEYSRKL 122
++E + L L + D E + L +L E +E +QE++K KL
Sbjct: 2716 QEELLVKETNMTSLQKDLSQVRDHLAEAKEKLSILEKE-DETEVQESKKACMFEPLPIKL 2774
Query: 123 EERFMTLAANHELMLRFKDEYKSENIKLREENEKLRLENSSLFSQALKDEEAKVLQLTVR 182
+ ++A+ + L+ ++ I ++ ++ L+ S+ +E +++
Sbjct: 2775 SK---SIASQTDGTLKISSSNQTPQILVKNAGIQINLQ-----SECSSEEVTEIIS---- 2822
Query: 183 CEALTGELETLKERCAQDACQAQAREKELLELQSQQACTHTKETEQLRSQLQTLKQQHQQ 242
T ++E ++E A E+L+++S+ H ETE TLK++H
Sbjct: 2823 --QFTEKIEKMQELHAA----------EILDMESR----HISETE-------TLKREHYV 2859
Query: 243 AVEQIAKAEETHSSLSQELQAR 264
AV+ + + T ++ Q L+++
Sbjct: 2860 AVQLLKEECGTLKAVIQCLRSK 2881
Score = 35.4 bits (80), Expect = 0.084
Identities = 27/141 (19%), Positives = 60/141 (42%), Gaps = 5/141 (3%)
Query: 212 LELQSQQACTHTKETEQLRSQLQTLKQQHQ----QAVEQIAKAEETHSSLSQELQARLQT 267
LE+ + E E+L +L+ ++ + Q +++ A + + +L A LQ
Sbjct: 157 LEMMESELAGKQHEIEELNRELEEMRVTYGTEGLQQLQEFEAAIKQRDGIITQLTANLQQ 216
Query: 268 VTREKEELLQLSIERGKVLQNKQAEICQLEEKLEIANEDRKH-ALERFEQEAVAVDSNLR 326
REK+E ++ +E + Q Q + QL+ + N A + + + + +
Sbjct: 217 ARREKDETMREFLELTEQSQKLQIQFQQLQASETLRNSTHSSTAADLLQAKQQILTHQQQ 276
Query: 327 VRELQRKVDGIQKAYDELRLQ 347
+ E ++ QK ++ +Q
Sbjct: 277 LEEQDHLLEDYQKKKEDFTMQ 297
Score = 31.6 bits (70), Expect = 1.2
Identities = 59/314 (18%), Positives = 124/314 (39%), Gaps = 61/314 (19%)
Query: 4 PMLQKQQAPRMDTPPPEERLEKQNEKLNNQEEETEFK--------------ELDGLREAL 49
P + K+ + R P ++L+K+ L +++ + + +D +RE +
Sbjct: 1076 PSVTKESSLRATQPSENDKLQKELNVLKSEQNDLRLQMEAQRICLSLVYSTHVDQVREYM 1135
Query: 50 ANLRGLSEEERSEKAMLRSRIEEQSQLICILKR---------RSDEALERCQILELLNAE 100
N E++++ ++ I Q + I L++ ++ E + + L LL +
Sbjct: 1136 EN-----EKDKALCSLKEELIFAQEEKIKELQKIHQLELQTMKTQETGDEGKPLHLLIGK 1190
Query: 101 LEEKMMQEAEKL-----KAQGEYSRKLEERFMTLAANHELMLRFKD---EYKSENIKLRE 152
L++ + +E GEY T A E+ K+ +Y SEN
Sbjct: 1191 LQKAVSEECSYFLQTLCSVLGEY--------YTPALKCEVNAEDKENSGDYISENEDPEL 1242
Query: 153 ENEKLRL----ENSSLFSQALKDEEAKVLQLTVRCEALTGE------LETLKERCAQDAC 202
++ + + EN + +E K+L L R + G+ LE +E ++
Sbjct: 1243 QDYRYEVQDFQENMHTLLNKVTEEYNKLLVLQTRLSKIWGQQTDGMKLEFGEENLPKEET 1302
Query: 203 QAQAREKELLELQ-------SQQACTHTKETEQLRSQLQTLKQQHQQAVEQIAKAEETHS 255
+ + ++ L+ S+ + E +L Q+Q L+ +Q+ + E+ +
Sbjct: 1303 EFLSIHSQMTNLEDIDVNHKSKLSSLQDLEKTKLEEQVQELESLISSLQQQLKETEQNYE 1362
Query: 256 SLSQELQARLQTVT 269
+ LQ RLQ V+
Sbjct: 1363 AEIHCLQKRLQAVS 1376
>gi|239745095 PREDICTED: hypothetical protein LOC645202 [Homo
sapiens]
Length = 570
Score = 70.5 bits (171), Expect = 2e-12
Identities = 68/294 (23%), Positives = 137/294 (46%), Gaps = 38/294 (12%)
Query: 20 EERLEKQNEKLNNQEEETEFKELDGLREALANLRGLSE---------EERSEKAMLRSRI 70
EE++++Q EK+ QEE+ +E + + E +R E E EK + +I
Sbjct: 301 EEKIQEQEEKIREQEEKMRRQE-EMMWEKEEKMRRQEEMMWEKEEKIRELEEKMHEQEKI 359
Query: 71 EEQSQLICILKRRSDEAL---ERCQILELLNAELEEKMMQEAEKLKAQGEYSRKLEERFM 127
EQ + KR+ +E + E+ Q E EEK+ ++ EK++ Q E ++ EE+
Sbjct: 360 REQEE-----KRQEEEKIREQEKRQEQEAKMWRQEEKIREQEEKIREQEEMMQEQEEK-- 412
Query: 128 TLAANHELMLRFKDEYKSENIKLREENEKLRLENSSLFSQALKDEEAKVLQLTVRCEALT 187
+ E M ++E + + K+R + EK+R + + Q K E + ++ E
Sbjct: 413 -MGEQEEKMWEQEEEMQEQEEKMRRQEEKIREQEKKIREQEEKIREQE--EMMQEQEEKM 469
Query: 188 GELETLKERCAQDACQAQAREKELLELQSQQACTHTKETEQLRSQLQTLKQQHQQAVEQI 247
GE E C+ +A+ +E E +Q ++ +++R Q + +++Q + EQ
Sbjct: 470 GEQE-------GKMCEQEAKMQEQEEKMRRQEEKIREQEKKIREQEEKIREQEEMMQEQE 522
Query: 248 AKAEETHSSLSQELQARLQTVTREKEELLQLSIERGKVLQNKQAEICQLEEKLE 301
K E + ++ + +E+EE ++ E+ ++ ++ + Q EEK++
Sbjct: 523 EKMWEQEEKMCEQ-----EEKMQEQEEKMRRQEEK---MREQEVRLRQQEEKMQ 568
Score = 69.3 bits (168), Expect = 5e-12
Identities = 80/355 (22%), Positives = 168/355 (47%), Gaps = 50/355 (14%)
Query: 2 RAPMLQKQQAPRMDTPPPEERLEKQNEKLNNQEEETE-FKELDGLREALANLRGLSEEER 60
RA +L QQ + + + L+ + KL Q EE E + L+ +E + +ER
Sbjct: 241 RAKLLLPQQQLQAEADHLGKELQSVSAKLQAQVEENELWNRLNQQQEEKMWRQEEKIQER 300
Query: 61 SEKAMLRSRIEEQSQLICILKRRSDEALERCQILELLNAELEEKMMQEAEKLKAQGEYSR 120
EK I+EQ + I R +E + R E + E EEKM ++ E + + E R
Sbjct: 301 EEK------IQEQEEKI----REQEEKMRR---QEEMMWEKEEKMRRQEEMMWEKEEKIR 347
Query: 121 KLEERFMTLAANHELMLRFKDEYKSENIKLREENEKLRLENSSLFSQA--LKDEEAKVLQ 178
+LEE+ + + +R ++E + E K+RE+ EK + + + ++ Q ++++E K+ +
Sbjct: 348 ELEEKM-----HEQEKIREQEEKRQEEEKIREQ-EKRQEQEAKMWRQEEKIREQEEKIRE 401
Query: 179 LTVRCEALTGELETLKERCAQDACQAQAREKELLELQS---QQACTHTKETEQLRSQLQT 235
+ ++ +E+ + + Q +E+++ + +Q ++ E++R Q +
Sbjct: 402 QEEMMQEQEEKMGEQEEKMWEQEEEMQEQEEKMRRQEEKIREQEKKIREQEEKIREQEEM 461
Query: 236 LKQQHQQAVEQIAKAEETHSSL-SQELQARLQ---------------TVTREKEELLQLS 279
+++Q ++ EQ K E + + QE + R Q RE+EE++Q
Sbjct: 462 MQEQEEKMGEQEGKMCEQEAKMQEQEEKMRRQEEKIREQEKKIREQEEKIREQEEMMQ-- 519
Query: 280 IERGKVLQNKQAEICQLEEKLEIANEDRKHALERFEQEAVAVDSNLRVRELQRKV 334
E+ + + ++ ++C+ EEK++ E + E+ ++ V R+R+ + K+
Sbjct: 520 -EQEEKMWEQEEKMCEQEEKMQEQEEKMRRQEEKMREQEV------RLRQQEEKM 567
Score = 65.5 bits (158), Expect = 8e-11
Identities = 72/345 (20%), Positives = 154/345 (44%), Gaps = 39/345 (11%)
Query: 24 EKQNEKLNNQEEETEFKELDGL---REALANLRGLSEEERSEKAMLRSRIEEQSQLICIL 80
EK +LN +E + + + L ++ A L +E +S A L++++EE +
Sbjct: 224 EKSEIQLNVKELKRKLERAKLLLPQQQLQAEADHLGKELQSVSAKLQAQVEENE----LW 279
Query: 81 KRRSDEALERCQILELLNAELEEKMMQEAEKLKAQGEYSRKLEERFMTLAANHELMLRFK 140
R + + E+ E E EEK+ ++ EK++ Q E R+ EE E M R +
Sbjct: 280 NRLNQQQEEKMWRQEEKIQEREEKIQEQEEKIREQEEKMRRQEEMMWE---KEEKMRRQE 336
Query: 141 DEYKSENIKLREENEKLRLENSSLFSQALKDEEAKVLQLTVRCEALTGELETLKERCAQD 200
+ + K+RE EK+ + + + EE K+ + R E E R +
Sbjct: 337 EMMWEKEEKIRELEEKMHEQEKIREQEEKRQEEEKIREQEKRQEQ-----EAKMWRQEEK 391
Query: 201 ACQAQAREKELLELQSQQACTHTKETEQLRSQLQTLKQQHQQAVEQIAKAEETHSSLSQE 260
+ + + +E E+ +Q ++ E++ Q + +++Q ++ Q K E + ++
Sbjct: 392 IREQEEKIREQEEMMQEQEEKMGEQEEKMWEQEEEMQEQEEKMRRQEEKIREQEKKIREQ 451
Query: 261 LQARLQTVTREKEELLQLSIERGKVLQNKQAEICQLEEKLEIANEDRKHALERFEQEAVA 320
+ RE+EE++Q E+ + + ++ ++C+ E K++ EQE
Sbjct: 452 -----EEKIREQEEMMQ---EQEEKMGEQEGKMCEQEAKMQ-------------EQEEKM 490
Query: 321 VDSNLRVRELQRKVDGIQKAYDELRLQSEAFKKHSLDLLSKEREL 365
++RE ++K I++ +++R Q E ++ + +E ++
Sbjct: 491 RRQEEKIREQEKK---IREQEEKIREQEEMMQEQEEKMWEQEEKM 532
Score = 56.6 bits (135), Expect = 4e-08
Identities = 60/279 (21%), Positives = 119/279 (42%), Gaps = 41/279 (14%)
Query: 5 MLQKQQAPRMDTPPPEERLEKQNEKLNNQEEETEFKELDGLREALANLRGLSEEERSEKA 64
M +K++ R E+ EK E E+ + +E + R+ +R + + E
Sbjct: 325 MWEKEEKMRRQEEMMWEKEEKIRELEEKMHEQEKIREQEEKRQEEEKIREQEKRQEQEAK 384
Query: 65 MLRS--RIEEQSQLICILKRRSDEALERCQILELLNAELEEKMMQEAEKLKAQGEYSRKL 122
M R +I EQ + I + E E+ E E EE+M ++ EK++ Q E R+
Sbjct: 385 MWRQEEKIREQEEKIREQEEMMQEQEEKMGEQEEKMWEQEEEMQEQEEKMRRQEEKIREQ 444
Query: 123 EERFMTLAANHELMLRFKDEYKSENIKLREENEKLRLENSSLFSQALK--DEEAKVLQLT 180
E+ K+RE+ EK+R + + Q K ++E K+ +
Sbjct: 445 EK------------------------KIREQEEKIREQEEMMQEQEEKMGEQEGKMCEQE 480
Query: 181 VRCEALTGELETLKERCAQDACQAQAREKELLELQSQQACTHTKETEQLRSQLQTLKQQH 240
+ + ++ +E+ + + + +E+++ E + E ++ Q + + +Q
Sbjct: 481 AKMQEQEEKMRRQEEKIREQEKKIREQEEKIRE-----------QEEMMQEQEEKMWEQE 529
Query: 241 QQAVEQIAKAEETHSSL-SQELQARLQTV-TREKEELLQ 277
++ EQ K +E + QE + R Q V R++EE +Q
Sbjct: 530 EKMCEQEEKMQEQEEKMRRQEEKMREQEVRLRQQEEKMQ 568
Score = 53.1 bits (126), Expect = 4e-07
Identities = 47/212 (22%), Positives = 99/212 (46%), Gaps = 23/212 (10%)
Query: 7 QKQQAPRMDTPPPEERLEKQNEKLNNQEEETEFKELDGLREALANLRGLSEEERSEKAML 66
+K+Q EE++ +Q EK+ QEE + +E + + E + EE + ++ +
Sbjct: 376 EKRQEQEAKMWRQEEKIREQEEKIREQEEMMQEQE-EKMGEQEEKMWEQEEEMQEQEEKM 434
Query: 67 R---SRIEEQSQLICILKRRSDEALERCQILELLNAELEEKMMQEAEKLKAQGEYSRKLE 123
R +I EQ + I R +E + +E+MMQE E+ GE K+
Sbjct: 435 RRQEEKIREQEKKI----REQEEKIRE-----------QEEMMQEQEE--KMGEQEGKMC 477
Query: 124 ERFMTLAANHELMLRFKDEYKSENIKLREENEKLRLENSSLFSQALK--DEEAKVLQLTV 181
E+ + E M R +++ + + K+RE+ EK+R + + Q K ++E K+ +
Sbjct: 478 EQEAKMQEQEEKMRRQEEKIREQEKKIREQEEKIREQEEMMQEQEEKMWEQEEKMCEQEE 537
Query: 182 RCEALTGELETLKERCAQDACQAQAREKELLE 213
+ + ++ +E+ + + + +E+++ E
Sbjct: 538 KMQEQEEKMRRQEEKMREQEVRLRQQEEKMQE 569
Score = 48.1 bits (113), Expect = 1e-05
Identities = 45/236 (19%), Positives = 109/236 (46%), Gaps = 32/236 (13%)
Query: 20 EERLEKQNEKLNNQEEETEFKELDGLREALANLRGLSEEERSEKAMLRSRIE-------- 71
+E++ +Q EK ++EE + +E + +E A + E+ R ++ +R + E
Sbjct: 356 QEKIREQEEK---RQEEEKIREQEKRQEQEAKMWRQEEKIREQEEKIREQEEMMQEQEEK 412
Query: 72 --EQSQLICILKRRSDEALERCQILELLNAELEEKMMQEAEKLKAQGEYSRKLEERFMTL 129
EQ + + + E E+ + E E E+K+ ++ EK++ Q E ++ EE+ +
Sbjct: 413 MGEQEEKMWEQEEEMQEQEEKMRRQEEKIREQEKKIREQEEKIREQEEMMQEQEEK---M 469
Query: 130 AANHELMLRFKDEYKSENIKLREENEKLRLENSSLFSQALKDEEAKVLQLTVRCEALTGE 189
M + + + + K+R + EK+R + + ++++E K+ + + +
Sbjct: 470 GEQEGKMCEQEAKMQEQEEKMRRQEEKIREQ-----EKKIREQEEKIREQEEMMQEQEEK 524
Query: 190 LETLKERCAQDACQAQAREKELLELQSQQACTHTKETEQLRSQLQTLKQQHQQAVE 245
+ +E+ + + Q +E+++ ++ E++R Q L+QQ ++ E
Sbjct: 525 MWEQEEKMCEQEEKMQEQEEKM-----------RRQEEKMREQEVRLRQQEEKMQE 569
Score = 32.0 bits (71), Expect = 0.93
Identities = 38/147 (25%), Positives = 69/147 (46%), Gaps = 41/147 (27%)
Query: 225 ETEQLRSQLQTLKQQHQQAVEQIAKAEETHSSLSQELQARLQTVTREKEELLQLSIERGK 284
E EQ S + T K++ + +E++ K + +LS EL T+T E+
Sbjct: 164 ELEQALSAVATQKKKADRYIEELTKERD---ALSLELYRN--TITDEE------------ 206
Query: 285 VLQNKQAEICQLEEKLEIANEDRKHALERFEQEAVAVDSNLRVRELQRKVDGIQKAYDEL 344
L+ K A+ L+EKL++ ++ + L V+EL+RK++ + +
Sbjct: 207 -LKEKNAK---LQEKLQLVESEKS-------------EIQLNVKELKRKLERAKLLLPQQ 249
Query: 345 RLQSEAFKKHSLDLLSKE-RELNGKLR 370
+LQ+EA D L KE + ++ KL+
Sbjct: 250 QLQAEA------DHLGKELQSVSAKLQ 270
>gi|114155142 nuclear pore complex-associated protein TPR [Homo
sapiens]
Length = 2363
Score = 70.5 bits (171), Expect = 2e-12
Identities = 74/307 (24%), Positives = 146/307 (47%), Gaps = 39/307 (12%)
Query: 21 ERLEKQNEKLNNQEEETEFKELDGLREALANLRG--LSEEERSEKAMLRSRIEEQSQLIC 78
E LEKQN L++Q E+ K + ++E + LSEE +S++ +L +++
Sbjct: 1150 EDLEKQNRLLHDQIEKLSDKVVASVKEGVQGPLNVSLSEEGKSQEQIL--------EILR 1201
Query: 79 ILKRRSDEALERCQILELLN------AELEEKMMQEAE-KLKAQGEYSRKLEERFMTLAA 131
++R + A R ++ ++ + EL E+ +QE + L A+ E K++ T+A
Sbjct: 1202 FIRREKEIAETRFEVAQVESLRYRQRVELLERELQELQDSLNAERE---KVQVTAKTMAQ 1258
Query: 132 NHELMLRFKDEYKSENIKLREENEKLRLENSSLFSQALKDEEAKVLQLTVRCEAL----- 186
+ ELM K+E + + E K+ E Q L+ +AKV +L + L
Sbjct: 1259 HEELMK------KTETMNVVMETNKMLREEKERLEQDLQQMQAKVRKLELDILPLQEANA 1312
Query: 187 -----TGELETLKERCAQDACQAQAREKELLELQSQQACTHTKETEQLRSQLQTLKQQHQ 241
+G L+ K+ +D + +AR + L+ SQQ T+E +L S+ + ++ Q
Sbjct: 1313 ELSEKSGMLQAEKKLLEEDVKRWKARNQHLV---SQQKDPDTEEYRKLLSEKEVHTKRIQ 1369
Query: 242 QAVEQIAKAEETHSSLSQELQARLQTVTREKEELLQLSIERGKVLQNKQAEICQLEEKLE 301
Q E+I + + + + L + KE+L ++ E+ + ++ A+I ++EK++
Sbjct: 1370 QLTEEIGRLKAEIARSNASLTNNQNLIQSLKEDLNKVRTEKETIQKDLDAKIIDIQEKVK 1429
Query: 302 IANEDRK 308
+ +K
Sbjct: 1430 TITQVKK 1436
Score = 57.0 bits (136), Expect = 3e-08
Identities = 72/315 (22%), Positives = 141/315 (44%), Gaps = 37/315 (11%)
Query: 20 EERLEKQNEKLNNQEEETEFKELDGLREALANLRGLSEEERSEKAMLRSRIEEQSQLICI 79
E+RL E+L N+ E + L+ L + L+ L+E+ + + I QSQ
Sbjct: 58 EKRLSHSQERLVNETRECQSLRLE-LEKLNNQLKALTEKNKELEIAQDRNIAIQSQFTRT 116
Query: 80 LKRRSDEALERCQILELLNAELE---EKMMQEAEKLKAQGEYSRKLEERFMTLAANHELM 136
+ E + + E L+ ELE E + + EKLK +L+ + L A+ ++
Sbjct: 117 KEELEAEKRDLIRTNERLSQELEYLTEDVKRLNEKLKESNTTKGELQLKLDELQAS-DVS 175
Query: 137 LRFKDEYKSENIKLREENEKLRLENSSLFSQALKDEEAKVLQLTVRCEALTGELETLKER 196
++++++ +L +E E L +N+ L ++ LK + ++L L E+ LK
Sbjct: 176 VKYREK------RLEQEKELLHSQNTWLNTE-LKTKTDELLALG---REKGNEILELK-- 223
Query: 197 CAQDACQAQAREKELLELQSQQACTHTKETEQLRSQLQTLKQQHQQAVEQIAKAEET--- 253
C + +++E+ L+ Q T E L+ ++ L + ++A EQ A EE
Sbjct: 224 -----CNLENKKEEVSRLEEQMNGLKTSN-EHLQKHVEDLLTKLKEAKEQQASMEEKFHN 277
Query: 254 -----------HSSLSQELQARLQTVTREKEELLQLSIERGKVLQNKQAEICQLEEKLEI 302
+ S + + +A+ +TR EEL +L E G+ + Q + ++E+ +
Sbjct: 278 ELNAHIKLSNLYKSAADDSEAKSNELTRAVEELHKLLKEAGEANKAIQDHLLEVEQSKDQ 337
Query: 303 ANEDRKHALERFEQE 317
++ + R E+E
Sbjct: 338 MEKEMLEKIGRLEKE 352
Score = 54.7 bits (130), Expect = 1e-07
Identities = 76/365 (20%), Positives = 155/365 (42%), Gaps = 40/365 (10%)
Query: 2 RAPMLQKQ-QAPRMDTPPPEERLEKQNEKLNNQEE--ETEFKELDGLREALANLRGLSEE 58
R MLQ + R + ER +K QE+ T ++L G E LA +E
Sbjct: 724 RYEMLQDNVEGYRREITSLHERNQKLTATTQKQEQIINTMTQDLRGANEKLAVAEVRAEN 783
Query: 59 ERSEKAMLRS---RIEEQSQLICILKRRSDEALERCQ----ILELLNAELEEKMMQEAEK 111
+ EK ML+ R+ +Q + + +R + L Q ILE E ++++ + EK
Sbjct: 784 LKKEKEMLKLSEVRLSQQRESLLAEQRGQNLLLTNLQTIQGILERSETETKQRLSSQIEK 843
Query: 112 LKAQ-GEYSRKLE---ERFMTLAANHELMLRFKDEYKSENIKLREENEKLRLENSSLFSQ 167
L+ + +KLE E+ TL N ++ L + + + L L L
Sbjct: 844 LEHEISHLKKKLENEVEQRHTLTRNLDVQLL-------DTKRQLDTETNLHLNTKELLKN 896
Query: 168 ALKDEEAKVLQLTVRCEALTGELETLKERCAQDACQAQAREKELLELQSQQACTHTKETE 227
A K+ L L ++ + A + Q + + + + ++TE
Sbjct: 897 AQKE-----------IATLKQHLSNMEVQVASQSSQRTGKGQPSNKEDVDDLVSQLRQTE 945
Query: 228 QLRSQLQTLKQQHQQAVEQIAKAEETHSSLSQELQARLQTVTREKEELLQLSIERGKVLQ 287
+ Q+ LK++ + + + + + +SL + L Q VT E + +++ ++ Q
Sbjct: 946 E---QVNDLKERLKTSTSNVEQYQAMVTSLEESLNKEKQ-VTEEVRKNIEVRLKESAEFQ 1001
Query: 288 NK-QAEICQLEEKLEIANEDRKHALERFEQEAVAVDSNLRVRELQRKV-DGIQKAYDELR 345
+ + ++ ++E++ + +D++ A+E EQ+ + L +Q +V + +Q+A L
Sbjct: 1002 TQLEKKLMEVEKEKQELQDDKRRAIESMEQQLSELKKTL--SSVQNEVQEALQRASTALS 1059
Query: 346 LQSEA 350
+ +A
Sbjct: 1060 NEQQA 1064
Score = 46.2 bits (108), Expect = 5e-05
Identities = 53/211 (25%), Positives = 92/211 (43%), Gaps = 35/211 (16%)
Query: 151 REENEKLRLENSSLFSQALKDEEAKVLQLTVRCEALTGELETLKERCAQDACQAQAREKE 210
R E KL + + L D+++++ + L G E K Q + + R
Sbjct: 11 RTELNKLPKSVQNKLEKFLADQQSEI-------DGLKGRHEKFKVESEQQYFEIEKR--- 60
Query: 211 LLELQSQQACTHTKETEQLRSQLQTLKQQHQQAVEQIAKAEETHSSLSQELQARLQT-VT 269
L ++ T+E + LR +L+ L Q + E+ + E ++Q+ +Q+ T
Sbjct: 61 -LSHSQERLVNETRECQSLRLELEKLNNQLKALTEKNKELE-----IAQDRNIAIQSQFT 114
Query: 270 REKEELLQLSIERGKVLQNKQAEICQLEEKLEIANEDRKHALERFEQEAVAVDSNLRVRE 329
R KEEL E+ +++ + +L ++LE ED K E+ ++ SN E
Sbjct: 115 RTKEEL---EAEKRDLIRTNE----RLSQELEYLTEDVKRLNEKLKE------SNTTKGE 161
Query: 330 LQRKVDGIQKA-----YDELRLQSEAFKKHS 355
LQ K+D +Q + Y E RL+ E HS
Sbjct: 162 LQLKLDELQASDVSVKYREKRLEQEKELLHS 192
Score = 45.1 bits (105), Expect = 1e-04
Identities = 60/249 (24%), Positives = 112/249 (44%), Gaps = 34/249 (13%)
Query: 138 RFKDEYKSENIKLREENEKLRLENSSLF---SQALKDEEAKVLQLTVRCEALTGELETLK 194
+F + +SE L+ +EK ++E+ + + L + +++ T C++L ELE L
Sbjct: 27 KFLADQQSEIDGLKGRHEKFKVESEQQYFEIEKRLSHSQERLVNETRECQSLRLELEKLN 86
Query: 195 ERC------------AQD---ACQAQ-AREKELLELQSQQACTHTKETEQLRSQLQTLKQ 238
+ AQD A Q+Q R KE LE + + + E+L +L+ L +
Sbjct: 87 NQLKALTEKNKELEIAQDRNIAIQSQFTRTKEELEAEKRDLI---RTNERLSQELEYLTE 143
Query: 239 QHQQAVEQIAKAEETHSSLS---QELQARLQTVTREKEELLQLSIERGKVLQNKQAEICQ 295
++ E++ ++ T L ELQA +V ++ L E+ K L + Q
Sbjct: 144 DVKRLNEKLKESNTTKGELQLKLDELQASDVSVKYREKRL-----EQEKELLHSQNTWLN 198
Query: 296 LEEKLEIANEDRKHALERFEQEAVAVDSNLRVRELQRKVDGIQKAYDELRLQSEAFKKHS 355
E K + D AL R E+ ++ + + +V +++ + L+ +E +KH
Sbjct: 199 TELKTKT---DELLALGR-EKGNEILELKCNLENKKEEVSRLEEQMNGLKTSNEHLQKHV 254
Query: 356 LDLLSKERE 364
DLL+K +E
Sbjct: 255 EDLLTKLKE 263
Score = 44.7 bits (104), Expect = 1e-04
Identities = 76/414 (18%), Positives = 183/414 (44%), Gaps = 69/414 (16%)
Query: 23 LEKQNEKLNNQEEETEFKELDGLREALANLRGLSEEERSEKAM--LRSRIEEQSQLICIL 80
LEK K N+ + KE++ L R E ER++KA+ L ++E+ + I L
Sbjct: 411 LEKLENKRINKYLDEIVKEVEAKAPILKRQR--EEYERAQKAVASLSVKLEQAMKEIQRL 468
Query: 81 KRRSDEALERCQILELLNAELEEKMMQEAEKLK--------AQGEYSRKLEE-RFMTLAA 131
+ +D+A ++ +LE N +E ++ +++++ A+G + + EE +++
Sbjct: 469 QEDTDKANKQSSVLERDNRRMEIQVKDLSQQIRVLLMELEEARGNHVIRDEEVSSADISS 528
Query: 132 NHELMLRFKDEYKSENIKLREENEKLRLENSSLFSQALKDEE----AKVLQLTVRCEALT 187
+ E++ + Y++ +L+++N++L + L ++E+ +K+ +L ++ E+
Sbjct: 529 SSEVISQHLVSYRNIE-ELQQQNQRLLVALRELGETREREEQETTSSKITELQLKLESAL 587
Query: 188 GELETLKE--RCAQDACQAQAREKELLEL------------------------------Q 215
ELE L++ + + R++++ +
Sbjct: 588 TELEQLRKSRQHQMQLVDSIVRQRDMYRILLSQTTGVAIPLHASSLDDVSLASTPKRPST 647
Query: 216 SQQACT-------HTKETEQLRSQLQTLKQQHQQAVEQIAKAEETHSSLSQELQARLQTV 268
SQ T + E + ++ L+ L++ + ++ A+ E+ + ++LQ ++ +
Sbjct: 648 SQTVSTPAPVPVIESTEAIEAKAALKQLQEIFENYKKEKAENEKIQNEQLEKLQEQVTDL 707
Query: 269 TREKEEL---LQLSIERGKVLQNK----QAEICQLEE---KLEIANEDRKHALERFEQEA 318
+ ++ L + +R ++LQ+ + EI L E KL + ++ + Q+
Sbjct: 708 RSQNTKISTQLDFASKRYEMLQDNVEGYRREITSLHERNQKLTATTQKQEQIINTMTQDL 767
Query: 319 VAVDSNLRVRELQRKVDGIQKAYDELRLQSEAFKKHSLDLLSKERELNGKLRHL 372
+ L V E+ + + ++K + L+L + LL+++R N L +L
Sbjct: 768 RGANEKLAVAEV--RAENLKKEKEMLKLSEVRLSQQRESLLAEQRGQNLLLTNL 819
Score = 36.2 bits (82), Expect = 0.049
Identities = 45/281 (16%), Positives = 119/281 (42%), Gaps = 16/281 (5%)
Query: 23 LEKQNEKLNNQEEETEFKELDGLREALANLRGLSEEERSEKAMLRSRIEEQSQLICILKR 82
+ + N L N + + L+E L +R +E+E +K + I+ Q ++ I +
Sbjct: 1382 IARSNASLTNNQNL-----IQSLKEDLNKVR--TEKETIQKDLDAKIIDIQEKVKTITQV 1434
Query: 83 RSDEALERCQILELLNAELEEKMMQEAEKLKAQGEYSRKLEERFMTLAANHELMLRFKD- 141
+ +I + EE Q+ + ++ + S +E+ +++ EL
Sbjct: 1435 K--------KIGRRYKTQYEELKAQQDKVMETSAQSSGDHQEQHVSVQEMQELKETLNQA 1486
Query: 142 EYKSENIKLREENEKLRLENSSLFSQALKDEEAKVLQLTVRCEALTGELETLKERCAQDA 201
E KS++++ + EN + L ++ L+++ ++ R + T +E+ Q
Sbjct: 1487 ETKSKSLESQVENLQKTLSEKETEARNLQEQTVQLQSELSRLRQDLQDRTTQEEQLRQQI 1546
Query: 202 CQAQAREKELLELQSQQACTHTKETEQLRSQLQTLKQQHQQAVEQIAKAEETHSSLSQEL 261
+ + + ++ + + +QL + + LKQ++ +Q + + ++L +
Sbjct: 1547 TEKEEKTRKAIVAAKSKIAHLAGVKDQLTKENEELKQRNGALDQQKDELDVRITALKSQY 1606
Query: 262 QARLQTVTREKEELLQLSIERGKVLQNKQAEICQLEEKLEI 302
+ R+ + RE E + +E+ Q ++ + + ++ +
Sbjct: 1607 EGRISRLERELREHQERHLEQRDEPQEPSNKVPEQQRQITL 1647
>gi|148596984 golgi autoantigen, golgin subfamily b, macrogolgin (with
transmembrane signal), 1 [Homo sapiens]
Length = 3259
Score = 69.7 bits (169), Expect = 4e-12
Identities = 67/345 (19%), Positives = 152/345 (44%), Gaps = 27/345 (7%)
Query: 21 ERLEKQNEKLNNQEEETEF-------------KELDGLREALANLRGLSEEERSEKAMLR 67
+ L+ +N++L +Q EET EL L++ L +L E+ + +K L
Sbjct: 2280 DTLQGENKELLSQLEETRHLYHSSQNELAKLESELKSLKDQLTDLSNSLEKCKEQKGNLE 2339
Query: 68 SRIEEQSQLICILKRRSDEALERCQILELLNAELEEKM-MQEAEKLKAQGEYSRKLEERF 126
I +Q I K ++ Q L + L E++ M+E + + ++
Sbjct: 2340 GIIRQQEADIQNSKFSYEQLETDLQASRELTSRLHEEINMKEQKIISLLSGKEEAIQVAI 2399
Query: 127 MTLAANHELMLR----FKDEYKSENIKLREENEKLRLENSSLFSQALKDEEAKVLQLTVR 182
L H+ ++ + + ENI L EEN+K ++ ++ + LK + + +Q +
Sbjct: 2400 AELRQQHDKEIKELENLLSQEEEENIVLEEENKKA-VDKTNQLMETLKTIKKENIQQKAQ 2458
Query: 183 CEALTGELETL---KERCAQDACQAQAREKELLELQSQQACTHTKETEQLRSQLQTLKQQ 239
++ + +L ++R D Q + R ++ + Q E +L+ +++ L+
Sbjct: 2459 LDSFVKSMSSLQNDRDRIVGDYQQLEERHLSIILEKDQLIQEAAAENNKLKEEIRGLRSH 2518
Query: 240 HQQAVEQIAKAEETHSSLSQELQARLQTVTREKEELLQLSIERGKVLQNKQAEICQLEEK 299
+ AK + ++L + ++++LL++ +++ K L+NK A++ + ++
Sbjct: 2519 MDDLNSENAKLDAELIQYREDLNQVITIKDSQQKQLLEVQLQQNKELENKYAKLEEKLKE 2578
Query: 300 LEIANEDRKHALERFEQEAVAVDSNLR-----VRELQRKVDGIQK 339
E ANED + + ++E + + + +L R+V +Q+
Sbjct: 2579 SEEANEDLRRSFNALQEEKQDLSKEIESLKVSISQLTRQVTALQE 2623
Score = 65.9 bits (159), Expect = 6e-11
Identities = 75/361 (20%), Positives = 151/361 (41%), Gaps = 32/361 (8%)
Query: 36 ETEFKELDGLREALANLRGLSEEERSEKAMLRSRIEEQSQLICILKRRSDEALERCQILE 95
+TE E + L +AL + +E E RI++ +C +K++ +E E + +
Sbjct: 1426 QTEIIEQEDLIKALHTQLEMQAKEHDE------RIKQLQVELCEMKQKPEEIGEESRAKQ 1479
Query: 96 LLNAELEEKMMQEAEKLKAQGEYSRKLE------ERFMTLAANHELMLRFKDEYKS---- 145
+ +L+ ++ E LK +L ER A+ E + +++ K
Sbjct: 1480 QIQRKLQAALISRKEALKENKSLQEELSLARGTIERLTKSLADVESQVSAQNKEKDTVLG 1539
Query: 146 -------ENIKLREENEKLRLENSSLFSQALKDEEAKVLQLTVRCEALTGELETLKERCA 198
E KL E ++ LEN SL S + + + + LT E L E+E+LK
Sbjct: 1540 RLALLQEERDKLITEMDRSLLENQSL-SSSCESLKLALEGLTEDKEKLVKEIESLKSSKI 1598
Query: 199 QDACQAQAREKEL---LELQSQQACTHTKETEQLRSQLQTLKQQHQQAVEQIAKAEETHS 255
++ + Q + KEL E+ Q + E E+++ ++ ++Q+ Q+ ++ E
Sbjct: 1599 AESTEWQEKHKELQKEYEILLQSYENVSNEAERIQHVVEAVRQEKQELYGKLRSTEANKK 1658
Query: 256 SLSQELQARLQTVTREKEELLQLSIERGKVLQNKQAEICQLEEKLEIANEDRKHALERFE 315
++LQ Q + KE++ + + + + + + E +L ++ A + K +E
Sbjct: 1659 ETEKQLQEAEQEMEEMKEKMRKFAKSKQQKILELEEENDRLRAEVHPAGDTAKECMETLL 1718
Query: 316 QEAVAVDSNL-RVR----ELQRKVDGIQKAYDELRLQSEAFKKHSLDLLSKERELNGKLR 370
++ L RV+ L +K + D L + + K +SK+ L +
Sbjct: 1719 SSNASMKEELERVKMEYETLSKKFQSLMSEKDSLSEEVQDLKHQIEGNVSKQANLEATEK 1778
Query: 371 H 371
H
Sbjct: 1779 H 1779
Score = 62.8 bits (151), Expect = 5e-10
Identities = 87/375 (23%), Positives = 167/375 (44%), Gaps = 65/375 (17%)
Query: 20 EERLEKQNEKLNNQEEETEFKE------LDGLREAL----ANLRGLSEEERSEKAMLRSR 69
E L+ E + EE KE L G EA+ A LR ++E E L S+
Sbjct: 2360 ETDLQASRELTSRLHEEINMKEQKIISLLSGKEEAIQVAIAELRQQHDKEIKELENLLSQ 2419
Query: 70 IEEQSQLICILKRRSDEALERC-QILELLNAELEEKMMQEAE--------------KLKA 114
EE++ +L+ + +A+++ Q++E L +E + Q+A+ + +
Sbjct: 2420 EEEEN---IVLEEENKKAVDKTNQLMETLKTIKKENIQQKAQLDSFVKSMSSLQNDRDRI 2476
Query: 115 QGEYSRKLEERFMTLAANHELMLRFKDEYKSENIKLREENEKLRLENSSLFSQALKDEEA 174
G+Y ++LEER +++ + +++ E +EN KL+EE LR L S+ K
Sbjct: 2477 VGDY-QQLEERHLSIILEKDQLIQ---EAAAENNKLKEEIRGLRSHMDDLNSENAK---- 2528
Query: 175 KVLQLTVRCEALTGELETLKERCAQDACQAQAREKELLELQSQQACTHTKETEQLRSQLQ 234
L EL +E Q +++K+LLE+Q QQ KE E ++L+
Sbjct: 2529 -----------LDAELIQYREDLNQVITIKDSQQKQLLEVQLQQ----NKELENKYAKLE 2573
Query: 235 TLKQQHQQAVEQIAKA----EETHSSLSQELQARLQTVTREKEELLQLSIERGKVLQNKQ 290
++ ++A E + ++ +E LS+E+++ ++++ ++ L E L + Q
Sbjct: 2574 EKLKESEEANEDLRRSFNALQEEKQDLSKEIESLKVSISQLTRQVTALQEEGTLGLYHAQ 2633
Query: 291 AEICQLE-EKLEIANEDRKHALERFEQEAVAVDSNLRVRELQRKVDGIQKAYDELRLQSE 349
++ + E +L + + E+E V V +E +KV I+ D+L+ + +
Sbjct: 2634 LKVKEEEVHRLSALFSSSQKRIAELEEELVCVQ-----KEAAKKVGEIE---DKLKKELK 2685
Query: 350 AFKKHSLDLLSKERE 364
H ++ E E
Sbjct: 2686 HL-HHDAGIMRNETE 2699
Score = 60.5 bits (145), Expect = 2e-09
Identities = 84/393 (21%), Positives = 157/393 (39%), Gaps = 48/393 (12%)
Query: 8 KQQAPRMDTPPPEERLEKQNEKLNNQEEETEFKELDG-LREALANLRGLSEEERSEKAML 66
++Q + D EE +E + K QE+E L L +A A S E E M+
Sbjct: 129 EEQLSKHDKSSTEEEMEIEKIKHKLQEKEELISTLQAQLTQAQAEQPAQSSTEMEEFVMM 188
Query: 67 RSRIEEQSQLICILKRRSDEALERCQILELLNAELEEKMMQEAEKLKAQGEYSRKL-EER 125
+ +++E+ + I L+ +L + E+ Q + A+ E +L E+
Sbjct: 189 KQQLQEKEEFISTLQA------------QLSQTQAEQAAQQVVREKDARFETQVRLHEDE 236
Query: 126 FMTLAANHELMLRFKDEYKSENIKLREENEKL--RLENSSLFSQALKDEEAKVLQLTVRC 183
+ L ++ + + + KL E E L R + L Q L E + L+ +
Sbjct: 237 LLQLVTQADVETEMQQKLRVLQRKLEEHEESLVGRAQVVDLLQQELTAAEQRNQILSQQL 296
Query: 184 EALTGELETLKERCAQDACQAQAREKELLELQSQQACTHTKETEQLRSQLQTLKQQHQQA 243
+ + E TL+ + + K LLE + L+ ++ L +Q +QA
Sbjct: 297 QQMEAEHNTLRNTVETE----REESKILLEKMELEVAERKLSFHNLQEEMHHLLEQFEQA 352
Query: 244 VEQIAKAEETHSSLSQELQARLQTVT-------REKEELLQ----LSIERGKVLQNKQAE 292
+ A+ E +S+L Q+ +A ++ T + +EL L + K+LQ+K +
Sbjct: 353 GQAQAELESRYSALEQKHKAEMEEKTSHILSLQKTGQELQSACDALKDQNSKLLQDKNEQ 412
Query: 293 -------ICQLEEKLEIANEDRKHALERFEQEAVAVDSNLRVREL---------QRKVDG 336
I QLE++L+ +++ L R + S ++ + +
Sbjct: 413 AVQSAQTIQQLEDQLQQKSKEISQFLNRLPLQQHETASQTSFPDVYNEGTQAVTEENIAS 472
Query: 337 IQKAYDELRLQSEAFKKHSLDLLSKERELNGKL 369
+QK EL + A S++L + E N KL
Sbjct: 473 LQKRVVELENEKGALLLSSIELEELKAE-NEKL 504
Score = 59.7 bits (143), Expect = 4e-09
Identities = 90/370 (24%), Positives = 158/370 (42%), Gaps = 55/370 (14%)
Query: 33 QEEETEFKEL--DGLREA---LANLRGLSEEERSEKAMLRSRIEEQSQLICILKRRSDEA 87
Q E FK L D EA LA+ L +E +S K ++S+++++ + L+RR ++A
Sbjct: 2074 QAELASFKVLLDDTQSEAARVLADNLKLKKELQSNKESVKSQMKQKDE---DLERRLEQA 2130
Query: 88 -----LERCQILELLNAELEEKMMQEA----------EKLKAQGEYSRKLEERFMTLAAN 132
E+ + E L+A EK+ E +K K + L+ LAA
Sbjct: 2131 EEKHLKEKKNMQEKLDALRREKVHLEETIGEIQVTLNKKDKEVQQLQENLDSTVTQLAAF 2190
Query: 133 HELMLRFKDEYK-------------SENIKLREENEKLRLENSSLFSQALKDEEAKVLQL 179
+ M +D+ S+ I+ +EE +L+ +N S+ L+ Q+
Sbjct: 2191 TKSMSSLQDDRDRVIDEAKKWERKFSDAIQSKEEEIRLKEDNCSVLKDQLR-------QM 2243
Query: 180 TVRCEALTGELETLKERCAQDACQAQAREKELLELQSQQACTHTKETEQLRSQLQTLKQQ 239
++ E EL+ R D +++ + ++LQ + T E ++L SQL+ +
Sbjct: 2244 SIHME----ELKINISRLEHDKQIWESKAQTEVQLQQKVCDTLQGENKELLSQLEETRHL 2299
Query: 240 HQQAVEQIAKAEETHSSLSQ---ELQARLQTVTREKEELLQLSIERGKVLQNKQAEICQL 296
+ + ++AK E SL +L L+ +K L + ++ +QN + QL
Sbjct: 2300 YHSSQNELAKLESELKSLKDQLTDLSNSLEKCKEQKGNLEGIIRQQEADIQNSKFSYEQL 2359
Query: 297 EEKLEIANEDRKHALERFEQEAVAVDSNLRVRELQRKVDGIQKAYDELRLQSEAFKKHSL 356
E L+ + E E + + S L +E + IQ A ELR Q + K
Sbjct: 2360 ETDLQASRELTSRLHEEINMKEQKIISLLSGKE-----EAIQVAIAELRQQHDKEIKELE 2414
Query: 357 DLLSKERELN 366
+LLS+E E N
Sbjct: 2415 NLLSQEEEEN 2424
Score = 56.6 bits (135), Expect = 4e-08
Identities = 82/357 (22%), Positives = 148/357 (41%), Gaps = 37/357 (10%)
Query: 25 KQNEKLNNQEEETEFKELDG-LREALANLRGLSEEERSEKAMLRSRIEEQ-SQLICILKR 82
K E QEE T+ L+ ++E L+ + L E EK L R+ Q ++L +
Sbjct: 1880 KDGELKMLQEEVTKMNLLNQQIQEELSRVTKLKETAEEEKDDLEERLMNQLAELNGSIGN 1939
Query: 83 RSDEALERCQILELLNAEL-----------EEKMMQEAEKLKAQGEYSRKLEERFMTLAA 131
+ + ELL +E+ EEK EK K + E ++ E+ A
Sbjct: 1940 YCQDVTDAQIKNELLESEMKNLKKCVSELEEEKQQLVKEKTKVESEIRKEYLEKIQ--GA 1997
Query: 132 NHELMLRFKDEYKSENIKLREENEKLRLENSSLFSQALKDEEAKVLQLTVRCEALTGELE 191
E + + E +K +++ K ++ + + + E V L +LE
Sbjct: 1998 QKEPGNKSHAKELQELLKEKQQEVKQLQKDCIRYQEKISALERTVKALEFVQTESQKDLE 2057
Query: 192 TLKERCAQDA-----CQAQ-AREKELLELQSQQACTHTKETEQLRSQLQT--------LK 237
KE AQ QA+ A K LL+ +A + +L+ +LQ+ +K
Sbjct: 2058 ITKENLAQAVEHRKKAQAELASFKVLLDDTQSEAARVLADNLKLKKELQSNKESVKSQMK 2117
Query: 238 QQHQQAVEQIAKAEETHSSLSQELQARLQTVTREKEELLQLSIERGKVLQNKQAEICQLE 297
Q+ + ++ +AEE H + +Q +L + REK L + E L K E+ QL+
Sbjct: 2118 QKDEDLERRLEQAEEKHLKEKKNMQEKLDALRREKVHLEETIGEIQVTLNKKDKEVQQLQ 2177
Query: 298 EKL-----EIANEDRKHALERFEQEAVAVDSNLRVRELQRKVDGIQKAYDELRLQSE 349
E L ++A + + + +++ V ++ R+ D IQ +E+RL+ +
Sbjct: 2178 ENLDSTVTQLAAFTKSMSSLQDDRDRVIDEAKKWERKFS---DAIQSKEEEIRLKED 2231
Score = 51.6 bits (122), Expect = 1e-06
Identities = 87/379 (22%), Positives = 157/379 (41%), Gaps = 82/379 (21%)
Query: 21 ERLEKQNEKLN---NQEEETEFKELDGLREALANLRGLSEEER----SEKAMLRSRIEEQ 73
ERL+ Q +L ++ +E K LD + ++NL L EE + + + + EE+
Sbjct: 687 ERLKSQILELELNFHKAQEIYEKNLDEKAKEISNLNQLIEEFKKNADNNSSAFTALSEER 746
Query: 74 SQLICILKRRSDEALERCQILELLNAELEEKMMQEAEKLKAQGEYSRKLEERFMTLAANH 133
QL+ +K S R Q+ +L E + EAE+ + S+ + +T H
Sbjct: 747 DQLLSQVKELSMVTELRAQVKQL------EMNLAEAERQRRLDYESQTAHDNLLTEQI-H 799
Query: 134 ELMLRFKDEYKSENIK---LREENEKLRLENS-------SLFSQALKDEEAKVLQLTVRC 183
L + E KS+++K L+ E + ++L+ S SL SQ L+++E++VL+ R
Sbjct: 800 SLSI----EAKSKDVKIEVLQNELDDVQLQFSEQSTLIRSLQSQ-LQNKESEVLEGAERV 854
Query: 184 EALTGELETLKERCAQDACQAQAREKELLE----LQSQQACTHTK--------------- 224
++ ++E L + +Q + ++ LLE +++ Q K
Sbjct: 855 RHISSKVEELSQALSQKELEITKMDQLLLEKKRDVETLQQTIEEKDQQVTEISFSMTEKM 914
Query: 225 ------------ETEQLRSQLQTLKQQHQQAVEQIAKAEETHSSLSQ------------- 259
E + L+ QL L + + EQ+ + E S L Q
Sbjct: 915 VQLNEEKFSLGVEIKTLKEQLNLLSRAEEAKKEQVEEDNEVSSGLKQNYDEMSPAGQISK 974
Query: 260 -ELQARLQTVTREKEE----LLQLSIERGKVLQNKQAEICQLEEKLEIANEDRKHALERF 314
ELQ + +E E+ L I R ++LQ + +LEE+L ++ K +
Sbjct: 975 EELQHEFDLLKKENEQRKRKLQAALINRKELLQ----RVSRLEEELANLKDESKKEIPLS 1030
Query: 315 EQEAVAVDSNLRVRELQRK 333
E E V+ + +E K
Sbjct: 1031 ETERGEVEEDKENKEYSEK 1049
Score = 50.4 bits (119), Expect = 3e-06
Identities = 79/392 (20%), Positives = 162/392 (41%), Gaps = 76/392 (19%)
Query: 8 KQQAPRMDTPPPEERLEKQNEKLNNQEEETEFKELDGLREALANLRGLSEEERSEKAMLR 67
K++ P +T E +K+N++ + + ++ +E++ L+ E+ E +R
Sbjct: 1024 KKEIPLSETERGEVEEDKENKEYSEKCVTSKCQEIE------IYLKQTISEKEVELQHIR 1077
Query: 68 SRIEE----QSQLICILKRRSDEALERCQILELLNAELEEK------------------- 104
+EE + Q ++K+ + ++ ++LL AE+ E
Sbjct: 1078 KDLEEKLAAEEQFQALVKQMNQTLQDKTNQIDLLQAEISENQAIIQKLITSNTDASDGDS 1137
Query: 105 --MMQEAEKLK-----AQGEYSRKLEERFMTLAANHE-LMLRFKDEYKSENIKLREENEK 156
+++E + + + +LEE+ + L E L + ++ S L++ EK
Sbjct: 1138 VALVKETVVISPPCTGSSEHWKPELEEKILALEKEKEQLQKKLQEALTSRKAILKKAQEK 1197
Query: 157 LRLENSSLFSQALKDEEAKVLQLTVRCEALTGELETLKERCAQDACQAQAREK---ELLE 213
R + LK ++ +L + + + E E + ++ Q Q Q RE +L
Sbjct: 1198 ERH-----LREELKQQKDDYNRLQEQFDEQSKENENIGDQLRQ--LQIQVRESIDGKLPS 1250
Query: 214 LQSQQACTHTKETEQLRSQLQTLKQQHQQAV------------EQIAKAEETHSSLSQEL 261
Q++C+ T E+ + +Q H Q V + A A + +S++Q +
Sbjct: 1251 TDQQESCSSTPGLEE--PLFKATEQHHTQPVLESNLCPDWPSHSEDASALQGGTSVAQ-I 1307
Query: 262 QARLQTVTREKEELLQLSIERGKVLQNKQAEICQLEEKLE-----------IANEDRKHA 310
+A+L+ + EK EL L K E+ QL+E++ +++E HA
Sbjct: 1308 KAQLKEIEAEKVELELKVSSTTSELTKKSEEVFQLQEQINKQGLEIESLKTVSHEAEVHA 1367
Query: 311 ---LERFEQEAVAVDSNLRVRELQRKVDGIQK 339
++ E + + +RELQ K+D +QK
Sbjct: 1368 ESLQQKLESSQLQIAGLEHLRELQPKLDELQK 1399
Score = 47.0 bits (110), Expect = 3e-05
Identities = 72/355 (20%), Positives = 152/355 (42%), Gaps = 53/355 (14%)
Query: 37 TEFKELDGLREALANLR----GLSEEERSEKAMLRSRIEEQSQLICILKRRSDEALERCQ 92
++ KEL + E A ++ L+E ER + S+ + L + S EA +
Sbjct: 751 SQVKELSMVTELRAQVKQLEMNLAEAERQRRLDYESQTAHDNLLTEQIHSLSIEAKSKDV 810
Query: 93 ILELLNAELEEKMMQEAEK------LKAQ----------------------GEYSRKLEE 124
+E+L EL++ +Q +E+ L++Q E S+ L +
Sbjct: 811 KIEVLQNELDDVQLQFSEQSTLIRSLQSQLQNKESEVLEGAERVRHISSKVEELSQALSQ 870
Query: 125 RFMTLAANHELMLRFKDEYKSENIKLREENEKLRLENSSLFSQALKDEEAKVLQLTVRCE 184
+ + + +L+L K + ++ + E+++++ + S+ K++QL
Sbjct: 871 KELEITKMDQLLLEKKRDVETLQQTIEEKDQQVTEISFSMTE--------KMVQLNEEKF 922
Query: 185 ALTGELETLKERCAQDACQAQAREKELLELQSQQACTHTKETEQLRSQLQTLKQQHQQAV 244
+L E++TLKE+ +A+ +KE +E ++ + + +++ Q K++ Q
Sbjct: 923 SLGVEIKTLKEQLNL-LSRAEEAKKEQVEEDNEVSSGLKQNYDEMSPAGQISKEELQHEF 981
Query: 245 EQIAKAEETHSSLSQELQARL-------QTVTREKEELLQLSIERGKVLQNKQAEICQLE 297
+ + K E ++LQA L Q V+R +EEL L E K + + E ++E
Sbjct: 982 DLLKKENEQRK---RKLQAALINRKELLQRVSRLEEELANLKDESKKEIPLSETERGEVE 1038
Query: 298 EKLEIANEDRKHALERFEQEAVAVDSNLRVRELQRKVDGIQKAYDELRLQSEAFK 352
E E K + ++ + + + +E++ + I+K +E E F+
Sbjct: 1039 EDKENKEYSEKCVTSKCQEIEIYLKQTISEKEVE--LQHIRKDLEEKLAAEEQFQ 1091
Score = 45.8 bits (107), Expect = 6e-05
Identities = 81/381 (21%), Positives = 167/381 (43%), Gaps = 58/381 (15%)
Query: 23 LEKQNEKLNNQEE---------ETEFKELDGLREALANLRG--------LSEEERSEKAM 65
LEK N++L +++E E + ++ +A+A+L+ L + +SE+
Sbjct: 2803 LEKLNQQLLSKDEQLLHLSSQLEDSYNQVQSFSKAMASLQNERDHLWNELEKFRKSEEGK 2862
Query: 66 LRSRIEEQS---QLICILKRRSDEALERCQILELLNAELEEKMMQEAEKLKAQGEYSRKL 122
RS + + ++ + K S +R ++L+ L L+++ +Q +++ +L
Sbjct: 2863 QRSAAQPSTSPAEVQSLKKAMSSLQNDRDRLLKELK-NLQQQYLQINQEITELHPLKAQL 2921
Query: 123 EERFMTLAANHELMLRFKDEYKSENIKLREENEKLRLENSSLFSQALKDEEAKVLQLTVR 182
+E + ++M ++E + EN+ + E +LR+E SS + +E ++ ++ +
Sbjct: 2922 QE-YQDKTKAFQIM---QEELRQENLSWQHELHQLRMEKSSWEIHERRMKEQYLMAISDK 2977
Query: 183 CEALTGELETLKERCAQDACQAQAREKELLELQSQQACTH-------TKETEQLRSQL-Q 234
+ L+ L+ L + Q Q + + S + ETE LR+QL
Sbjct: 2978 DQQLS-HLQNLIRELRSSSSQTQPLKVQYQRQASPETSASPDGSQNLVYETELLRTQLND 3036
Query: 235 TLKQQHQQAVEQIAKAEETHSSLSQELQARLQTVTREKEELLQLSIERGKVLQNKQAEIC 294
+LK+ HQ+ + + ++ +S+ SQ L+ EK L + + L+ Q
Sbjct: 3037 SLKEIHQKEL----RIQQLNSNFSQLLE--------EKNTLSIQLCDTSQSLRENQQHYG 3084
Query: 295 QLEEKLEIANEDRKHALERFEQEAVAVDSNLRVRE-LQRKVDGIQKAYD--ELRLQSEAF 351
L + LE+ QE A N+ V ++ +G+ + D ELR ++F
Sbjct: 3085 DLLNHCAV--------LEKQVQELQAGPLNIDVAPGAPQEKNGVHRKSDPEELREPQQSF 3136
Query: 352 KKHSLDLLSKERELNGKLRHL 372
+ L + +E+N +LR L
Sbjct: 3137 SEAQQQLCNTRQEVN-ELRKL 3156
Score = 38.9 bits (89), Expect = 0.008
Identities = 90/395 (22%), Positives = 160/395 (40%), Gaps = 62/395 (15%)
Query: 20 EERL---EKQNEKLNN-----QEEETEF-KELDGLREALANLR----GLSEEERSE--KA 64
EE+L E+ NE L QEE+ + KE++ L+ +++ L L EE A
Sbjct: 2573 EEKLKESEEANEDLRRSFNALQEEKQDLSKEIESLKVSISQLTRQVTALQEEGTLGLYHA 2632
Query: 65 MLRSRIEEQSQLICILKRRSDEALERCQILELLNAELEEKMMQEAEKLKAQGEY------ 118
L+ + EE +L + E + L + E +K+ + +KLK + ++
Sbjct: 2633 QLKVKEEEVHRLSALFSSSQKRIAELEEELVCVQKEAAKKVGEIEDKLKKELKHLHHDAG 2692
Query: 119 -----SRKLEERFMTLAANHELMLRFKDEYKSENIKLREENEKLRLENSSLFSQALKDEE 173
+ EER LA + M + EN L + + SSL Q +D
Sbjct: 2693 IMRNETETAEERVAELARDLVEMEQKLLMVTKENKGLTAQIQSFGRSMSSL--QNSRDHA 2750
Query: 174 AKVL-QLTVRCEALTGELETLKER----------CAQDACQAQAREKELL---ELQSQQA 219
+ L +L + +A EL LKE+ ++ A + E+ L E +QQ
Sbjct: 2751 NEELDELKRKYDASLKELAQLKEQGLLNRERDALLSETAFSMNSTEENSLSHLEKLNQQL 2810
Query: 220 CTHTKETEQLRSQLQTLKQQHQQAVEQIAKAEETHSSLSQELQARLQTVTREKEELLQLS 279
+ ++ L SQL+ Q Q + +A + L EL+ R+ EE Q S
Sbjct: 2811 LSKDEQLLHLSSQLEDSYNQVQSFSKAMASLQNERDHLWNELEK-----FRKSEEGKQRS 2865
Query: 280 IERGKVLQNKQAEICQLEEKLEIANEDRKH---ALERFEQEAVAVDSNL--------RVR 328
+ AE+ L++ + DR L+ +Q+ + ++ + +++
Sbjct: 2866 AAQP---STSPAEVQSLKKAMSSLQNDRDRLLKELKNLQQQYLQINQEITELHPLKAQLQ 2922
Query: 329 ELQRKVDGIQKAYDELRLQSEAFKKHSLDLLSKER 363
E Q K Q +ELR ++ ++ +H L L E+
Sbjct: 2923 EYQDKTKAFQIMQEELRQENLSW-QHELHQLRMEK 2956
Score = 32.0 bits (71), Expect = 0.93
Identities = 52/242 (21%), Positives = 98/242 (40%), Gaps = 29/242 (11%)
Query: 22 RLEKQNEKLNNQEEETEF-KELDGLREALANLRGLSEEERSEKAMLRS-RIEEQSQLICI 79
R+EK + +++ + + ++ + + L++L+ L E RS + + +++ Q Q
Sbjct: 2953 RMEKSSWEIHERRMKEQYLMAISDKDQQLSHLQNLIRELRSSSSQTQPLKVQYQRQASPE 3012
Query: 80 LKRRSDEALERCQILELLNAELEEKMMQEAEKLKAQGEYSRKLEERFMTLAANHELMLRF 139
D + ELL +L + + + +K E R L +N +L
Sbjct: 3013 TSASPDGSQNLVYETELLRTQLNDSLKEIHQK-----------ELRIQQLNSNFSQLL-- 3059
Query: 140 KDEYKSENIKLREENEKLRLENSSLFSQALKDEEAKVLQLTVRCEALTGELETLKERCAQ 199
+E + +I+L + ++ LR EN + L VL+ V+ E G L A
Sbjct: 3060 -EEKNTLSIQLCDTSQSLR-ENQQHYGDLLN--HCAVLEKQVQ-ELQAGPLNIDVAPGAP 3114
Query: 200 DACQAQAREKELLELQS---------QQACTHTKETEQLRSQLQTLKQQHQQAVEQIAKA 250
R+ + EL+ QQ C +E +LR L+ + Q A ++ A
Sbjct: 3115 QEKNGVHRKSDPEELREPQQSFSEAQQQLCNTRQEVNELRKLLEEERDQRVAAENALSVA 3174
Query: 251 EE 252
EE
Sbjct: 3175 EE 3176
>gi|31563507 GRIP and coiled-coil domain-containing 2 [Homo sapiens]
Length = 1684
Score = 68.6 bits (166), Expect = 9e-12
Identities = 75/370 (20%), Positives = 166/370 (44%), Gaps = 27/370 (7%)
Query: 20 EERLEKQNEKLNNQEEET-----EFKELDGLREALANLRGLSEEERSEKAMLRSRIEEQS 74
+ + + EK +E E E KEL R L L+ + S K S ++E
Sbjct: 891 KSEIHNEKEKCFIKEHENLKPLLEQKELRDRRAELILLKDSLAKSPSVKNDPLSSVKELE 950
Query: 75 QLICILKRRSDEALERCQILELLNAELEEKMMQEAEKLKAQGEYSRKLEERFMTLAANHE 134
+ I L++ E E+ ++L+ + ++++ ++ + E L L+A+
Sbjct: 951 EKIENLEKECKEKEEKINKIKLVAVKAKKELDSSRKETQTVKEELESLRSEKDQLSASMR 1010
Query: 135 LMLRFKDEYKSENIKLREENEKLRLEN--SSLFSQALKDEEAKVLQLTVRCEALTGELET 192
+++ + YK+ ++ +++E+L +E ++ F ++D ++ T++CE + + E
Sbjct: 1011 DLIQGAESYKNLLLEYEKQSEQLDVEKERANNFEHRIEDLTRQLRNSTLQCETINSDNED 1070
Query: 193 LKERCAQDACQAQAREKELLELQSQQACTHTKETEQLRSQLQTLKQQHQQAVEQIAKAEE 252
L R A+ E ++LE+Q +A KE E + Q + ++H V ++ + +
Sbjct: 1071 LLARIETLQSNAKLLEVQILEVQRAKAMV-DKELEAEKLQKEQKIKEHATTVNELEELQV 1129
Query: 253 THSSLSQELQARLQTVTREKEELLQLSI-------------ERGKVLQNKQAEICQLEEK 299
++LQ +Q + K++ Q ++ E + L NK +I LE++
Sbjct: 1130 QLQKEKKQLQKTMQELELVKKDAQQTTLMNMEIADYERLMKELNQKLTNKNNKIEDLEQE 1189
Query: 300 LEIANEDRKHALERFEQEAVAVDSNLRVRELQRKVDGIQKAYDELRLQSEAFKKHSLDLL 359
++I +K E ++E ++ S+ V++ + K I++ + + + K+ D L
Sbjct: 1190 IKI----QKQKQETLQEEITSLQSS--VQQYEEKNTKIKQLLVKTKKELADSKQAETDHL 1243
Query: 360 SKERELNGKL 369
+ L G+L
Sbjct: 1244 ILQASLKGEL 1253
Score = 62.8 bits (151), Expect = 5e-10
Identities = 93/371 (25%), Positives = 165/371 (44%), Gaps = 49/371 (13%)
Query: 22 RLEKQNEKLNNQEEETEFKELDGLREALANLRG-----LSEEERSEKAM---LRSRIEEQ 73
RL+ +NEKL +Q+E EL+ + L G LS+ + K + + S EE+
Sbjct: 539 RLQGENEKLLSQQELVP--ELENTIKNLQEKNGVYLLSLSQRDTMLKELEGKINSLTEEK 596
Query: 74 SQLICILKRRSDEA---LERCQILELLNAELEEKMMQEAEKLKAQGEYSRKLEERFMTLA 130
I LK +E ++C+ E L EL +K+ Q + Y+ +LE++ L
Sbjct: 597 DDFINKLKNSHEEMDNFHKKCEREERLILELGKKVEQTIQ-------YNSELEQKVNELT 649
Query: 131 ANHELMLRFKDEYKSENIKLR-------EENEKLRLENSSLFSQALKDEEAKVLQLTVRC 183
E L+ KD+ + KL E+ E L E SL+ + K K QL+
Sbjct: 650 GGLEETLKEKDQNDQKLEKLMVQMKVLSEDKEVLSAEVKSLYEENNKLSSEKK-QLSRDL 708
Query: 184 EALTGELET--LKERCAQDACQAQAREKEL-LELQSQQACTHTKETEQL-----RSQLQT 235
E + E LKE Q EK+L L ++ Q E EQ+ ++QL
Sbjct: 709 EVFLSQKEDVILKEHITQ-------LEKKLQLMVEEQDNLNKLLENEQVQKLFVKTQLYG 761
Query: 236 LKQQHQQAVEQIAKAEETHSSLSQELQARLQTVTREKEELLQLSIERGKVLQNKQAEICQ 295
++ V + ++ ++ + LQA +++ + EE L+ +R + + + EI
Sbjct: 762 FLKEMGSEVSEDSEEKD----VVNVLQAVGESLAKINEEKCNLAFQRDEKVLELEKEIKC 817
Query: 296 LEEKLEIANEDRKHALERFEQEAVAVDSNLRVRELQRKVDGIQKAYDELRLQSEAFKKHS 355
L+E+ + E+ K L +EQE V + L E+Q + + +Q E++ +E + +
Sbjct: 818 LQEESVVQCEELKSLLRDYEQEKVLLRKEL--EEIQSEKEALQSDLLEMKNANEKTRLEN 875
Query: 356 LDLLSKERELN 366
+LL + E++
Sbjct: 876 QNLLIQVEEVS 886
Score = 54.3 bits (129), Expect = 2e-07
Identities = 97/401 (24%), Positives = 157/401 (39%), Gaps = 71/401 (17%)
Query: 24 EKQNEKLNNQEEETEFKE--LDGLREALANLRGLSEEERSEKAMLRSRIEEQSQLICILK 81
EKQ+E+L+ ++E E ++ L L N E S+ L +RIE
Sbjct: 1027 EKQSEQLDVEKERANNFEHRIEDLTRQLRNSTLQCETINSDNEDLLARIETL-------- 1078
Query: 82 RRSDEALERCQILELLNA------ELEEKMMQEAEKLKAQGEYSRKLEERFMTLAAN--- 132
+S+ L QILE+ A ELE + +Q+ +K+K +LEE + L
Sbjct: 1079 -QSNAKLLEVQILEVQRAKAMVDKELEAEKLQKEQKIKEHATTVNELEELQVQLQKEKKQ 1137
Query: 133 -----HELMLRFKDEYKSENIKL---------REENEKLRLENSSL--FSQALKDEEAKV 176
EL L KD ++ + + +E N+KL +N+ + Q +K ++ K
Sbjct: 1138 LQKTMQELELVKKDAQQTTLMNMEIADYERLMKELNQKLTNKNNKIEDLEQEIKIQKQKQ 1197
Query: 177 LQLTVRCEALTGELETLKERCAQ-------------DACQA-------QAREKELLELQS 216
L +L ++ +E+ + D+ QA QA K LE
Sbjct: 1198 ETLQEEITSLQSSVQQYEEKNTKIKQLLVKTKKELADSKQAETDHLILQASLKGELEASQ 1257
Query: 217 QQACTH-------TKETEQLRSQLQTLKQQHQQAVEQIAKAEETHSSLSQELQARLQTVT 269
QQ + T E ++ L+T +QHQ+ + + + +A TVT
Sbjct: 1258 QQVEVYKIQLAEITSEKHKIHEHLKTSAEQHQRTLSAYQQRVTALQEECRAAKAEQATVT 1317
Query: 270 REKEELLQLSIERGKVL-QNKQAEICQLEEKLEIANEDRKHALERFEQEAVAVDSNLRVR 328
E E + VL Q K + Q E E A ++R+H +Q + + +
Sbjct: 1318 SEFE---SYKVRVHNVLKQQKNKSMSQAE--TEGAKQEREHLEMLIDQLKIKLQDS--QN 1370
Query: 329 ELQRKVDGIQKAYDELRLQSEAFKKHSLDLLSKERELNGKL 369
LQ V +Q E E K + +SKE EL KL
Sbjct: 1371 NLQINVSELQTLQSEHDTLLERHNKMLQETVSKEAELREKL 1411
Score = 53.9 bits (128), Expect = 2e-07
Identities = 94/380 (24%), Positives = 166/380 (43%), Gaps = 60/380 (15%)
Query: 23 LEKQNEKLNNQEEETEFKELDGLREALA-----NLRGLSEEERSEKAMLRSRIEEQSQLI 77
L+KQ + ++++ET +L + EA + N+ L EE KA+ + EE +L+
Sbjct: 201 LQKQLDATTDEKKET-VTQLQNIIEANSQHYQKNINSLQEELLQLKAIHQ---EEVKELM 256
Query: 78 CILKRRSDEALERCQILELLNAELEEKMMQ--EAEKLKAQGEYSRKLEE-RFMTLAANHE 134
C ++ + E +I +L EL+E +++ EA + Q +Y +LE R T AN +
Sbjct: 257 CQIEASAKE--HEAEINKL--NELKENLVKQCEASEKNIQKKYECELENLRKATSNANQD 312
Query: 135 LML--------RFKDEYKSENIKLREENEKLRLENSSLFSQALKDEEAKVLQLTVRCEAL 186
+ F ++ +E +K E+ K S+ LKDE + L ++ E
Sbjct: 313 NQICSILLQENTFVEQVVNEKVKHLEDTLKELESQHSI----LKDEVTYMNNLKLKLEM- 367
Query: 187 TGELETLKERCAQDACQAQAREKELLELQSQQACTHTK--------------ETEQLRSQ 232
+ + +K+ + + + ELL + +Q C K EQ +
Sbjct: 368 --DAQHIKDEFFHEREDLEFKINELLLAKEEQGCVIEKLKSELAGLNKQFCYTVEQHNRE 425
Query: 233 LQTLKQQHQQAVEQIAKAEETHSSLSQELQARLQ-TVTREKEELLQLSIERGKVLQNKQA 291
+Q+LK+QHQ ++I++ ET S S++ + L + KE+ L E+ + + N ++
Sbjct: 426 VQSLKEQHQ---KEISELNETFLSDSEKEKLTLMFEIQGLKEQCENLQQEKQEAILNYES 482
Query: 292 EICQLEEKLEIANEDRKHALERFEQEAVAVDSNLR--VRELQRKVDGIQKAYDEL----- 344
L E +EI + + + QE ++ V ELQ+K+ D L
Sbjct: 483 ----LREIMEILQTELGESAGKISQEFESMKQQQASDVHELQQKLRTAFTEKDALLETVN 538
Query: 345 RLQSEAFKKHSLDLLSKERE 364
RLQ E K S L E E
Sbjct: 539 RLQGENEKLLSQQELVPELE 558
Score = 47.0 bits (110), Expect = 3e-05
Identities = 80/357 (22%), Positives = 153/357 (42%), Gaps = 41/357 (11%)
Query: 23 LEKQNEKLNNQE-EETEFKELDGLREAL-ANLRGLSEEERSEKAMLRSRIEEQSQLICIL 80
LEK+ E+L ++ E + L E L A L +E E+ ++ + I+ + ++ +
Sbjct: 51 LEKEIEELRSKPVTEGTGDIIKALTERLDALLLEKAETEQQCLSLKKENIKMKQEVEDSV 110
Query: 81 KRRSD--EALERCQILELLNAE-LEEKMMQEAEKLKAQGEYSRKLEERFMTLAANHELML 137
+ D + LE+ I + E L+ ++M K +K E M L
Sbjct: 111 TKMGDAHKELEQSHINYVKEIENLKNELMAVRSKYSEDKANLQKQLEEAMNTQLELSEQL 170
Query: 138 RFKDEYKSENIKLREENEKLRLENSSLFSQALKDEEAKVLQLTVRCEALTGE-LETLKER 196
+F++ + KL+EE EK+R E ++L L + +A T E ET+ +
Sbjct: 171 KFQNNSEDNVKKLQEEIEKIR-----------PGFEEQILYLQKQLDATTDEKKETVTQL 219
Query: 197 CAQDACQAQAREKELLELQS---QQACTHTKETEQLRSQLQTLKQQHQQAVEQIAKAEET 253
+Q +K + LQ Q H +E ++L Q++ ++H+ +I K E
Sbjct: 220 QNIIEANSQHYQKNINSLQEELLQLKAIHQEEVKELMCQIEASAKEHE---AEINKLNEL 276
Query: 254 HSSLSQELQARLQTVTREKEELLQLSIERGKVLQNKQAEICQ--LEEKL---EIANEDRK 308
+L ++ +A + + ++ E L+ ++ + N+ +IC L+E ++ NE K
Sbjct: 277 KENLVKQCEASEKNIQKKYECELE-NLRKATSNANQDNQICSILLQENTFVEQVVNEKVK 335
Query: 309 HALERFEQEAVAVDSNLRVRELQRKVDGIQKAY-DELRLQSEAFKKHSLDLLSKERE 364
H ++ L+ E Q + + Y + L+L+ E +H D ERE
Sbjct: 336 H-----------LEDTLKELESQHSILKDEVTYMNNLKLKLEMDAQHIKDEFFHERE 381
>gi|222418637 golgi autoantigen, golgin subfamily a-like [Homo
sapiens]
Length = 750
Score = 68.2 bits (165), Expect = 1e-11
Identities = 79/355 (22%), Positives = 169/355 (47%), Gaps = 27/355 (7%)
Query: 24 EKQNEKLNNQEEETEFKELDGL---REALANLRGLSEEERSEKAMLRSRIEEQSQLICIL 80
EK +LN +E + + + L ++ A L +E +S A L++++EE ++L L
Sbjct: 236 EKSEIQLNVKELKRKLERAKLLLPQQQLQAEADHLGKELQSVSAKLQAQVEE-NELWNRL 294
Query: 81 KRRSDEAL----ERCQILELLNAELEEKMMQEAEKLKAQGEYSRKLEERFMT----LAAN 132
++ +E + E+ Q E E EEK+ ++ EK++ Q E R+ EE +
Sbjct: 295 NQQQEEKMWRQEEKIQEWEEKIQEQEEKIREQEEKIREQEEKMRRQEEMMWEKEEKMRRQ 354
Query: 133 HELMLRFKDEYKSENIKLREENEKLRLENSSLFSQALKDEEAKVLQLTVRCEALTGELET 192
E+M +++ + + + E+ EK+R + ++ ++E K+ +L E E E
Sbjct: 355 EEMMWEKEEKMRRQEEMMWEKEEKMRRQEEMMW-----EKEEKIREL----EEKMHEQEK 405
Query: 193 LKERCAQDACQAQAREKELLELQSQQACTHTKETEQLRSQLQTLKQQHQQAVEQIAKAEE 252
++E+ + + + RE+E + +Q ++ E++R Q + +++Q ++ Q K E
Sbjct: 406 IREQEEKRQEEEKIREQE---KRQEQEAKMWRQEEKIREQEEKIREQEKKMWRQEEKIHE 462
Query: 253 THSSLSQELQARLQTVTREKEEL-LQLSIERGKVLQNKQAE-ICQLEEKLEIANEDRKHA 310
+E + + + R++E++ Q I R K ++Q E I + EEK+ E +
Sbjct: 463 QEKIREEEKRQEQEEMWRQEEKIHEQEEIWRQKEKMHEQEEKIRKQEEKVWRQEEKIREQ 522
Query: 311 LERF-EQEAVAVDSNLRVRELQRKVDGIQKAYDELRLQSEAFKKHSLDLLSKERE 364
E+ EQE ++RE + +K +++ ++ E ++ D + ++ E
Sbjct: 523 EEKIREQEEKMWRQEEKIREQEEMWREEEKMHEQEKIWEEEKRQEQEDKMWRQEE 577
Score = 67.8 bits (164), Expect = 2e-11
Identities = 75/351 (21%), Positives = 156/351 (44%), Gaps = 49/351 (13%)
Query: 7 QKQQAPRMDTPPPEERLEKQNEKLNNQE-----EETEFKELDGLREALANLRGLSEEERS 61
+K+Q EE++ +Q EK+ QE +E + E + +RE +
Sbjct: 423 EKRQEQEAKMWRQEEKIREQEEKIREQEKKMWRQEEKIHEQEKIREEEKRQEQEEMWRQE 482
Query: 62 EKAMLRSRIEEQSQLICILKRRSDEALERCQILELLNAELEEKMMQEAEKLKAQGEYSRK 121
EK + I Q + + + + + E+ E E EEK+ ++ EK+ Q E R+
Sbjct: 483 EKIHEQEEIWRQKEKMHEQEEKIRKQEEKVWRQEEKIREQEEKIREQEEKMWRQEEKIRE 542
Query: 122 LEERFMTLAANHELMLRFKDEYKSENI--------KLREENEKLRLENSSLFSQALK--- 170
EE + HE +++E + E K+RE+ EK+ + + Q K
Sbjct: 543 QEEMWREEEKMHEQEKIWEEEKRQEQEDKMWRQEEKIREQEEKVWRQEEKIREQEEKRQE 602
Query: 171 ------DEEAKVLQLTVRCEALTGELETLKERCAQDACQAQAREKELLELQSQQACTHTK 224
+E K+ + + + ++ +E+ + Q +E+++ E Q ++ C +
Sbjct: 603 QEEKMWKQEEKIREQEEKIQEQEEKIREQEEKIREQEEMTQEQEEKMGE-QEEKMC---E 658
Query: 225 ETEQLRSQLQTLKQQHQQAVEQIAKAEETHSSLSQELQARLQTVTREKEELLQLSIERGK 284
+ E+++ Q +T+ +Q ++ EQ K E + RE+EE++Q E+ +
Sbjct: 659 QEEKMQEQEETMWRQEEKIREQEKKIREQEEKI------------REQEEMMQ---EQEE 703
Query: 285 VLQNKQAEICQLEEKLEIANEDRKHALER-FEQEAVAVDSNLRVRELQRKV 334
+ ++ ++C+ EEK++ E + E+ +EQE +R+R+ + K+
Sbjct: 704 KMWEQEEKMCEQEEKMQEQEEKMRRQEEKMWEQE-------VRLRQQEEKM 747
Score = 59.7 bits (143), Expect = 4e-09
Identities = 65/354 (18%), Positives = 165/354 (46%), Gaps = 37/354 (10%)
Query: 20 EERLEKQNEKLNNQEEETEFKELDGLREALANLRGLSEEERSEKAML-----RSRIEEQS 74
+E L+++N KL + + E ++ E N++ L + K +L ++ +
Sbjct: 216 DEELKEKNAKLQEKLQLVESEK----SEIQLNVKELKRKLERAKLLLPQQQLQAEADHLG 271
Query: 75 QLICILKRRSDEALERCQILELLNAELEEKMMQEAEKLKAQGEYSRKLEERFMTLAANHE 134
+ + + + +E ++ LN + EEKM ++ EK++ E+ K++E+ + E
Sbjct: 272 KELQSVSAKLQAQVEENELWNRLNQQQEEKMWRQEEKIQ---EWEEKIQEQEEKIREQEE 328
Query: 135 LMLRFKDEYKSENIKLREENEKLRLENSSLFSQALKDEEAKVLQLTVRCEALTGELETLK 194
+ +++ + + + E+ EK+R + ++ K+E+ + R E + E E
Sbjct: 329 KIREQEEKMRRQEEMMWEKEEKMRRQEEMMWE---KEEKMR------RQEEMMWEKEEKM 379
Query: 195 ERCAQDACQAQAREKELLELQSQQACTHTKETEQLRSQLQTLKQQHQQAVEQIAKA---E 251
R + + + + +EL E +Q +E E+ R + + +++Q ++ EQ AK E
Sbjct: 380 RRQEEMMWEKEEKIRELEEKMHEQE--KIREQEEKRQEEEKIREQEKRQ-EQEAKMWRQE 436
Query: 252 ETHSSLSQELQARLQTVTREKEELLQLSIERGKVLQNKQAEICQLEEKLEIANEDRKHAL 311
E ++++ + + + R++E++ + R + + +Q E+ + EEK+ E +
Sbjct: 437 EKIREQEEKIREQEKKMWRQEEKIHEQEKIREEEKRQEQEEMWRQEEKIHEQEEIWRQKE 496
Query: 312 ERFEQEAVAVDSNLRVRELQRKVDGIQKAYDELRLQSEAFKKHSLDLLSKEREL 365
+ EQE +++++ + + + +++R Q E ++ + +E ++
Sbjct: 497 KMHEQE----------EKIRKQEEKVWRQEEKIREQEEKIREQEEKMWRQEEKI 540
Score = 55.8 bits (133), Expect = 6e-08
Identities = 61/284 (21%), Positives = 120/284 (42%), Gaps = 53/284 (18%)
Query: 20 EERLEKQNEKLNNQEEETEFKELDGLREALANLRGLSEEERSEKAMLRSRIEEQSQLICI 79
EE++ +Q EK+ QEE+ +++ + +RE R + EK + +EQ +
Sbjct: 516 EEKIREQEEKIREQEEKM-WRQEEKIREQEEMWREEEKMHEQEKIWEEEKRQEQEDKMWR 574
Query: 80 LKRRSDEALERCQILELLNAELEEKMMQEAEKLKAQGEYSRKLEERFMTLAANHELMLRF 139
+ + E E+ E E EEK ++ EK+ Q E R+ EE+
Sbjct: 575 QEEKIREQEEKVWRQEEKIREQEEKRQEQEEKMWKQEEKIREQEEKI------------- 621
Query: 140 KDEYKSENIKLREENEKLRLENSSLFSQALKDEEAKVLQLTVRCEALTGELETLKERCAQ 199
+ + K+RE+ EK+R + ++T E GE E ++ C Q
Sbjct: 622 ----QEQEEKIREQEEKIREQE----------------EMTQEQEEKMGEQE--EKMCEQ 659
Query: 200 DACQAQAREKELLELQSQQACTHTKETEQLRSQLQTLKQQHQQAVEQIAKAEETHSSL-- 257
+ E +Q T ++ E++R Q + +++Q ++ EQ +E +
Sbjct: 660 E------------EKMQEQEETMWRQEEKIREQEKKIREQEEKIREQEEMMQEQEEKMWE 707
Query: 258 SQELQARLQTVTREKEELLQLSIERGKVLQNKQAEICQLEEKLE 301
+E + +E+EE ++ E+ + ++ + Q EEK++
Sbjct: 708 QEEKMCEQEEKMQEQEEKMRRQEEK---MWEQEVRLRQQEEKMQ 748
Score = 55.1 bits (131), Expect = 1e-07
Identities = 47/200 (23%), Positives = 100/200 (50%), Gaps = 25/200 (12%)
Query: 20 EERLEKQNEKLNNQEEETEFKELDGLREALANLRGLSEEERSEKA----MLRSRIEEQSQ 75
E+++ +Q EK+ QEE+ +++ + +RE EE+R E+ +I EQ +
Sbjct: 569 EDKMWRQEEKIREQEEKV-WRQEEKIRE--------QEEKRQEQEEKMWKQEEKIREQEE 619
Query: 76 LICILKRRSDEALERCQILELLNAELEEKMMQEAEKLKAQGEYSRKLEERFMTLAANHEL 135
I + + E E+ + E + E EEKM ++ EK+ Q E K++E+ E
Sbjct: 620 KIQEQEEKIREQEEKIREQEEMTQEQEEKMGEQEEKMCEQEE---KMQEQ-------EET 669
Query: 136 MLRFKDEYKSENIKLREENEKLRLENSSLFSQALK--DEEAKVLQLTVRCEALTGELETL 193
M R +++ + + K+RE+ EK+R + + Q K ++E K+ + + + ++
Sbjct: 670 MWRQEEKIREQEKKIREQEEKIREQEEMMQEQEEKMWEQEEKMCEQEEKMQEQEEKMRRQ 729
Query: 194 KERCAQDACQAQAREKELLE 213
+E+ + + + +E+++ E
Sbjct: 730 EEKMWEQEVRLRQQEEKMQE 749
Score = 48.1 bits (113), Expect = 1e-05
Identities = 37/130 (28%), Positives = 61/130 (46%), Gaps = 6/130 (4%)
Query: 20 EERLEKQNEKLNNQEEETEFKE--LDGLREALANLRGLSEEERSEKAMLRSRIEEQSQLI 77
EE++ +Q EK+ QEE T+ +E + E + +E+ +I EQ + I
Sbjct: 625 EEKIREQEEKIREQEEMTQEQEEKMGEQEEKMCEQEEKMQEQEETMWRQEEKIREQEKKI 684
Query: 78 CILKRRSDEALERCQILELLNAELEEKMMQEAEKLKAQGEYSRKLEERFMTLAANHELML 137
+ + E E Q E E EEKM ++ EK++ Q E R+ EE+ E+ L
Sbjct: 685 REQEEKIREQEEMMQEQEEKMWEQEEKMCEQEEKMQEQEEKMRRQEEKMW----EQEVRL 740
Query: 138 RFKDEYKSEN 147
R ++E E+
Sbjct: 741 RQQEEKMQEH 750
>gi|41406064 myosin, heavy polypeptide 10, non-muscle [Homo sapiens]
Length = 1976
Score = 68.2 bits (165), Expect = 1e-11
Identities = 85/378 (22%), Positives = 170/378 (44%), Gaps = 53/378 (14%)
Query: 21 ERLEKQNEKLNNQEEETEFKELDGLREALANLRGLSEEERSEKAMLRSRIEEQSQLICIL 80
++LEK +L QE + +LD R+ +NL E+ +K + EE+S +
Sbjct: 1416 DKLEKTKNRLQ-QELDDLTVDLDHQRQVASNL------EKKQKKFDQLLAEEKS-----I 1463
Query: 81 KRRSDEALERCQILELLNAELEEKMMQEAEKLKAQGEYSRKLEERFMTLAANHELMLRFK 140
R E +R E E E K + A L+ E + E + L A+ E ++ K
Sbjct: 1464 SARYAEERDRA---EAEAREKETKALSLARALEEALEAKEEFERQNKQLRADMEDLMSSK 1520
Query: 141 D-------EYKSENIKLREENEKLRLENSSLFSQALKDEEAKVLQLTVRCEALTGELET- 192
D E + L ++ E++R + L + E+AK L+L V +A+ + E
Sbjct: 1521 DDVGKNVHELEKSKRALEQQVEEMRTQLEELEDELQATEDAK-LRLEVNMQAMKAQFERD 1579
Query: 193 LKERCAQDACQAQAREKELLELQSQQ---------ACTHTKETE----QLRSQLQTLKQQ 239
L+ R Q+ + + K++ EL+++ A K+ E L +Q++ +
Sbjct: 1580 LQTRDEQNEEKKRLLIKQVRELEAELEDERKQRALAVASKKKMEIDLKDLEAQIEAANKA 1639
Query: 240 HQQAVEQIAKAEETHSSLSQELQARLQTVTREKEELLQLSIERGKVLQNKQAEICQLEEK 299
+ ++Q+ K + + ++ Q L+ ++E+ S E K L++ +AEI QL+E+
Sbjct: 1640 RDEVIKQLRKLQ----AQMKDYQRELEEARASRDEIFAQSKESEKKLKSLEAEILQLQEE 1695
Query: 300 LEIANEDRKHALERFEQEAVAVDSNL--------RVRELQRKVDGIQKAYDE----LRLQ 347
L + R+HA + ++ A + ++ R L+ ++ +++ +E + L
Sbjct: 1696 LASSERARRHAEQERDELADEITNSASGKSALLDEKRRLEARIAQLEEELEEEQSNMELL 1755
Query: 348 SEAFKKHSLDLLSKEREL 365
++ F+K +L + + EL
Sbjct: 1756 NDRFRKTTLQVDTLNAEL 1773
Score = 66.2 bits (160), Expect = 4e-11
Identities = 102/414 (24%), Positives = 180/414 (43%), Gaps = 59/414 (14%)
Query: 7 QKQQAPRMDTPPPEERLEKQNEKLNNQEEET-----EFKELDGLREA-LANLR-GLSEEE 59
+ ++A R + L ++ E L + E+T +EL RE +A L+ L EE
Sbjct: 1128 ESEKASRNKAEKQKRDLSEELEALKTELEDTLDTTAAQQELRTKREQEVAELKKALEEET 1187
Query: 60 RSEKAMLR-------SRIEEQSQLICILKRRSDEALERCQILELLNAEL--EEKMMQEAE 110
++ +A ++ + +EE S+ + KR + Q LE N EL E K++Q+
Sbjct: 1188 KNHEAQIQDMRQRHATALEELSEQLEQAKRFKANLEKNKQGLETDNKELACEVKVLQQ-- 1245
Query: 111 KLKAQGEYSRK-LEERFMTLAANHELMLRFKDEYKSENIKLREENE-------------- 155
+KA+ E+ RK L+ + L A R + E + KL+ E +
Sbjct: 1246 -VKAESEHKRKKLDAQVQELHAKVSEGDRLRVELAEKASKLQNELDNVSTLLEEAEKKGI 1304
Query: 156 KLRLENSSLFSQA------LKDEEAKVLQLTVRCEALTGELETLKERCAQDACQAQAREK 209
K + +SL SQ L++E + L L+ R L E +L+E+ ++ + EK
Sbjct: 1305 KFAKDAASLESQLQDTQELLQEETRQKLNLSSRIRQLEEEKNSLQEQQEEEEEARKNLEK 1364
Query: 210 ELLELQSQQACTHTK---------ETEQLRSQLQTLKQQHQQAVEQIAKAEETHSSLSQE 260
++L LQSQ A T K E+ + +L + Q +E+ A A +
Sbjct: 1365 QVLALQSQLADTKKKVDDDLGTIESLEEAKKKLLKDAEALSQRLEEKALAYDKLEKTKNR 1424
Query: 261 LQARLQTVTREKEELLQLSIERGKVLQNKQAEICQL--EEKLEIANEDRKHALERFEQEA 318
LQ L +T + + Q++ L+ KQ + QL EEK + ++A ER EA
Sbjct: 1425 LQQELDDLTVDLDHQRQVASN----LEKKQKKFDQLLAEEK----SISARYAEERDRAEA 1476
Query: 319 VAVDSNLRVRELQRKVDGIQKAYDELRLQSEAFKKHSLDLLSKERELNGKLRHL 372
A + + L R ++ +A +E Q++ + DL+S + ++ + L
Sbjct: 1477 EAREKETKALSLARALEEALEAKEEFERQNKQLRADMEDLMSSKDDVGKNVHEL 1530
Score = 63.2 bits (152), Expect = 4e-10
Identities = 87/391 (22%), Positives = 174/391 (44%), Gaps = 82/391 (20%)
Query: 5 MLQKQQAPRMDTPPPEERLEKQNEKLNNQEEETEFKELDGLREALANLRGLSEEERSEKA 64
+LQ++ +++ +LE++ L Q+E EEE + K
Sbjct: 1323 LLQEETRQKLNLSSRIRQLEEEKNSLQEQQE---------------------EEEEARKN 1361
Query: 65 MLRSRIEEQSQLICILKRRSDEALERCQILELLNAELEEKMMQEAEKLKAQGEYSRKLEE 124
+ + + QSQL K++ D+ L + LE E ++K++++AE L S++LEE
Sbjct: 1362 LEKQVLALQSQL-ADTKKKVDDDLGTIESLE----EAKKKLLKDAEAL------SQRLEE 1410
Query: 125 RFMTLAANHELMLRFKDEYKSENIKLREENEKLR--LENSSLFSQALKDEEAKVLQLTVR 182
+ + D+ + +L++E + L L++ + L+ ++ K QL
Sbjct: 1411 KALAY-----------DKLEKTKNRLQQELDDLTVDLDHQRQVASNLEKKQKKFDQLLAE 1459
Query: 183 CEALTGELETLKERCAQDACQAQAREKELLELQSQQACTHT--------KETEQLRSQLQ 234
++++ +ER D +A+AREKE L +A ++ +QLR+ ++
Sbjct: 1460 EKSISARY--AEER---DRAEAEAREKETKALSLARALEEALEAKEEFERQNKQLRADME 1514
Query: 235 TLKQQHQQAVEQIAKAEETHSSLSQELQARLQTVTREKEELLQLSIERGKVLQ-NKQAEI 293
L + + + E++ +L Q+++ ++T E E+ LQ + + L+ N QA
Sbjct: 1515 DLMSSKDDVGKNVHELEKSKRALEQQVE-EMRTQLEELEDELQATEDAKLRLEVNMQAMK 1573
Query: 294 CQLEEKLEI---ANEDRKHAL------------ERFEQEAVAVDS----NLRVRELQRKV 334
Q E L+ NE++K L + +Q A+AV S + +++L+ ++
Sbjct: 1574 AQFERDLQTRDEQNEEKKRLLIKQVRELEAELEDERKQRALAVASKKKMEIDLKDLEAQI 1633
Query: 335 DGIQKAYDELRLQSEAFKKHSLDLLSKEREL 365
+ KA DE+ Q +K + +REL
Sbjct: 1634 EAANKARDEVIKQ---LRKLQAQMKDYQREL 1661
Score = 61.2 bits (147), Expect = 1e-09
Identities = 90/413 (21%), Positives = 169/413 (40%), Gaps = 66/413 (15%)
Query: 20 EERLEKQNEKLNNQEEETE---------FKELDGLREALANLRGLSEEERSEKAMLRSRI 70
+E L K EK E E E +E + L E L L E +A L ++
Sbjct: 858 DEELLKVKEKQTKVEGELEEMERKHQQLLEEKNILAEQLQAETELFAEAEEMRARLAAKK 917
Query: 71 EEQSQLICILKRRSDEALERCQIL---------------ELLNAELEEKMMQEAEKLKAQ 115
+E +++ L+ R +E ER QIL E L+ E + + EK+ A+
Sbjct: 918 QELEEILHDLESRVEEEEERNQILQNEKKKMQAHIQDLEEQLDEEEGARQKLQLEKVTAE 977
Query: 116 GEYSRKLEERFMTLAANHELMLRFK----DEYKSENIKLREENEK----LRLENS----- 162
+ +K+EE + L + ++ K D + +L EE EK ++ N
Sbjct: 978 AKI-KKMEEEILLLEDQNSKFIKEKKLMEDRIAECSSQLAEEEEKAKNLAKIRNKQEVMI 1036
Query: 163 SLFSQALKDEEAKVLQLTVRCEALTGELETLKERCAQ-----DACQAQAREKELLELQSQ 217
S + LK EE +L L GE L+++ A+ D + Q +KE ELQ
Sbjct: 1037 SDLEERLKKEEKTRQELEKAKRKLDGETTDLQDQIAELQAQIDELKLQLAKKE-EELQGA 1095
Query: 218 QA---------CTHTKETEQLRSQLQTLKQQHQQAVEQIAKAEETHSSLSQELQARLQTV 268
A K +L++Q+ L++ + KAE+ LS+EL+A +
Sbjct: 1096 LARGDDETLHKNNALKVVRELQAQIAELQEDFESEKASRNKAEKQKRDLSEELEA----L 1151
Query: 269 TREKEELLQLSIERGKVLQNKQAEICQLEEKLEIANEDRKHALERFEQEAVAVDSNLRVR 328
E E+ L + + ++ ++ E+ +L++ LE ++ + ++ Q L +
Sbjct: 1152 KTELEDTLDTTAAQQELRTKREQEVAELKKALEEETKNHEAQIQDMRQRHATALEELSEQ 1211
Query: 329 ---------ELQRKVDGIQKAYDELRLQSEAFKKHSLDLLSKERELNGKLRHL 372
L++ G++ EL + + ++ + K ++L+ +++ L
Sbjct: 1212 LEQAKRFKANLEKNKQGLETDNKELACEVKVLQQVKAESEHKRKKLDAQVQEL 1264
Score = 59.7 bits (143), Expect = 4e-09
Identities = 69/311 (22%), Positives = 140/311 (45%), Gaps = 30/311 (9%)
Query: 80 LKRRSDEALERCQILELLNAELEE------KMMQE----AEKLKAQGEYSRKLEERFMTL 129
L+ + +E L+ + + ELEE ++++E AE+L+A+ E + EE L
Sbjct: 854 LQAKDEELLKVKEKQTKVEGELEEMERKHQQLLEEKNILAEQLQAETELFAEAEEMRARL 913
Query: 130 AAN--------HELMLRFKDEYKSENIKLREENEKLRLENSSLFSQALKDEEAKVLQLTV 181
AA H+L R ++E + I L+ E +K++ L Q L +EE +L +
Sbjct: 914 AAKKQELEEILHDLESRVEEEEERNQI-LQNEKKKMQAHIQDLEEQ-LDEEEGARQKLQL 971
Query: 182 RCEALTGELETLKER--CAQDACQAQAREKELLELQSQQACTHTKETEQLRSQLQTLKQQ 239
+++ ++E +D +EK+L+E + + + E E+ L ++ +
Sbjct: 972 EKVTAEAKIKKMEEEILLLEDQNSKFIKEKKLMEDRIAECSSQLAEEEEKAKNLAKIRNK 1031
Query: 240 HQQAVEQIAKAEETHSSLSQELQARLQTVTREKEELLQLSIERGKVLQNKQAEICQLEEK 299
+ + + + + QEL+ + + E +L E QA+I +L+ +
Sbjct: 1032 QEVMISDLEERLKKEEKTRQELEKAKRKLDGETTDLQDQIAE-------LQAQIDELKLQ 1084
Query: 300 LEIANEDRKHALERFEQEAVAVDSNLR-VRELQRKVDGIQKAYDELRLQSEAFKKHSLDL 358
L E+ + AL R + E + ++ L+ VRELQ ++ +Q+ ++ + +K DL
Sbjct: 1085 LAKKEEELQGALARGDDETLHKNNALKVVRELQAQIAELQEDFESEKASRNKAEKQKRDL 1144
Query: 359 LSKERELNGKL 369
+ L +L
Sbjct: 1145 SEELEALKTEL 1155
Score = 49.7 bits (117), Expect = 4e-06
Identities = 43/174 (24%), Positives = 85/174 (48%), Gaps = 17/174 (9%)
Query: 203 QAQAREKELLELQSQQACTH------TKETEQLRSQLQTLKQQHQQAVEQIAKAEETHSS 256
+ QA+++ELL+++ +Q ++ +QL + L +Q Q E A+AEE +
Sbjct: 853 ELQAKDEELLKVKEKQTKVEGELEEMERKHQQLLEEKNILAEQLQAETELFAEAEEMRAR 912
Query: 257 LSQELQARLQTVTREKEELLQLSIERGKVLQNK----QAEICQLEEKLEIANEDRKHALE 312
L+ + Q L+ + + E ++ ER ++LQN+ QA I LEE+L ++ + A +
Sbjct: 913 LAAKKQ-ELEEILHDLESRVEEEEERNQILQNEKKKMQAHIQDLEEQL----DEEEGARQ 967
Query: 313 RFEQEAVAVDSNLR--VRELQRKVDGIQKAYDELRLQSEAFKKHSLDLLSKERE 364
+ + E V ++ ++ E+ D K E +L + + S L +E +
Sbjct: 968 KLQLEKVTAEAKIKKMEEEILLLEDQNSKFIKEKKLMEDRIAECSSQLAEEEEK 1021
Score = 41.6 bits (96), Expect = 0.001
Identities = 47/191 (24%), Positives = 91/191 (47%), Gaps = 19/191 (9%)
Query: 20 EERLEKQN---EKLNNQEEETEFKELDGLREALANLRGLSEEERSEKAMLRSRIEEQSQL 76
EE LE++ E LN++ +T ++D L LA R S ++S+ A R ++E Q++
Sbjct: 1742 EEELEEEQSNMELLNDRFRKTTL-QVDTLNAELAAER--SAAQKSDNA--RQQLERQNKE 1796
Query: 77 ICILKRRSDEALER-----CQILELLNAELEEKMMQEAEKLKAQGEYSRKLEERFMTLAA 131
+ + + A++ LE +LEE++ QEA++ A + R+ E++ +
Sbjct: 1797 LKAKLQELEGAVKSKFKATISALEAKIGQLEEQLEQEAKERAAANKLVRRTEKKLKEIFM 1856
Query: 132 NHELMLRFKDEYKSENIKLREENEKLRL------ENSSLFSQALKDEEAKVLQLTVRCEA 185
E R D+YK + K ++L+ E ++ + + + + ++ T E
Sbjct: 1857 QVEDERRHADQYKEQMEKANARMKQLKRQLEEAEEEATRANASRRKLQRELDDATEANEG 1916
Query: 186 LTGELETLKER 196
L+ E+ TLK R
Sbjct: 1917 LSREVSTLKNR 1927
Score = 40.4 bits (93), Expect = 0.003
Identities = 72/298 (24%), Positives = 124/298 (41%), Gaps = 79/298 (26%)
Query: 6 LQKQQAPRMDTPPPEERLEKQNEKLNNQEEETEFK------ELDGLREALAN---LRGLS 56
L+K QA D E +++ Q +E+E K E+ L+E LA+ R +
Sbjct: 1647 LRKLQAQMKDYQRELEEARASRDEIFAQSKESEKKLKSLEAEILQLQEELASSERARRHA 1706
Query: 57 EEERSE------------------KAMLRSRI--------EEQSQLICILKRRSDEALER 90
E+ER E K L +RI EEQS + + R L+
Sbjct: 1707 EQERDELADEITNSASGKSALLDEKRRLEARIAQLEEELEEEQSNMELLNDRFRKTTLQ- 1765
Query: 91 CQILELLNAELEEKMMQEAEKLKAQ-GEYSRKLEERFMTLAANHELMLRFKDEYKSENIK 149
++ LNAEL AE+ AQ + +R+ ER +N +
Sbjct: 1766 ---VDTLNAEL------AAERSAAQKSDNARQQLER--------------------QNKE 1796
Query: 150 LREENEKLRLENSSLFSQALKDEEAKVLQLTVRCEALTGELETLKERCAQDACQAQAREK 209
L+ + ++L S F + EAK+ QL + E + KER A + + EK
Sbjct: 1797 LKAKLQELEGAVKSKFKATISALEAKIGQLEEQLE------QEAKERAAANKL-VRRTEK 1849
Query: 210 ELLEL------QSQQACTHTKETEQLRSQLQTLKQQHQQAVEQIAKAEETHSSLSQEL 261
+L E+ + + A + ++ E+ ++++ LK+Q ++A E+ +A + L +EL
Sbjct: 1850 KLKEIFMQVEDERRHADQYKEQMEKANARMKQLKRQLEEAEEEATRANASRRKLQREL 1907
>gi|71061468 centromere protein E [Homo sapiens]
Length = 2701
Score = 68.2 bits (165), Expect = 1e-11
Identities = 78/402 (19%), Positives = 194/402 (48%), Gaps = 55/402 (13%)
Query: 22 RLEKQNEKLNNQEEETEFKELDGLREALANLRGLSEEERSEKAMLRSRIEEQSQLICILK 81
R+E + +LN + +E++ +E+ L + NL+ + E + L+ I E I +
Sbjct: 1325 RIEMERLRLNEKFQESQ-EEIKSLTKERDNLKTIKEALEVKHDQLKEHIRETLAKIQESQ 1383
Query: 82 RRSDEAL---ERCQILELLNAELEEKMMQEAEKLKAQGEY---SRKLEE---RFMTLAAN 132
+ +++L E+ + +E+E+ +++ L+ + E S++L+E ++A
Sbjct: 1384 SKQEQSLNMKEKDNETTKIVSEMEQFKPKDSALLRIEIEMLGLSKRLQESHDEMKSVAKE 1443
Query: 133 HELMLRFKDEYKSENIKLREENEKL---RLENSSLFSQA---LKDEEAKVLQLTVRCEAL 186
+ + R ++ +SE+ +L+E +++ LE A LK++E + +L V
Sbjct: 1444 KDDLQRLQEVLQSESDQLKENIKEIVAKHLETEEELKVAHCCLKEQEETINELRVNLSEK 1503
Query: 187 TGELETLKERCAQDACQAQAREKELLELQSQQACTHTKETEQLRSQLQTLKQQHQQAVEQ 246
E+ T++++ + Q + +E+ E + Q E ++ ++L+ K+ H++A +
Sbjct: 1504 ETEISTIQKQLEAINDKLQNKIQEIYEKEEQFNIKQISEVQEKVNELKQFKE-HRKAKDS 1562
Query: 247 IAKAEETH----SSLSQELQARLQTVTREKEELLQ----LSIERGKVLQNKQAEICQLEE 298
++ E+ ++ QE Q +Q + +EKEE+ + L IER ++ +N + + +++E
Sbjct: 1563 ALQSIESKMLELTNRLQESQEEIQIMIKEKEEMKRVQEALQIERDQLKENTKEIVAKMKE 1622
Query: 299 ---------KLEIANEDR------KHALERFEQEAVAVDS----NLR-----------VR 328
K+ NE + +H E+FE + + +++ N+R +R
Sbjct: 1623 SQEKEYQFLKMTAVNETQEKMCEIEHLKEQFETQKLNLENIETENIRLTQILHENLEEMR 1682
Query: 329 ELQRKVDGIQKAYDELRLQSEAFKKHSLDLLSKERELNGKLR 370
+ ++ D ++ + L+++ + K++ + ++++ E +L+
Sbjct: 1683 SVTKERDDLRSVEETLKVERDQLKENLRETITRDLEKQEELK 1724
Score = 67.4 bits (163), Expect = 2e-11
Identities = 87/414 (21%), Positives = 173/414 (41%), Gaps = 72/414 (17%)
Query: 24 EKQNEKLNNQEEETEFKELDGLREALANLRGLSEEERSEKAMLRSRIEEQSQLICILKRR 83
+KQ+ + N + T + + + E + L +E+ + ML S I E+ QL LK
Sbjct: 1017 KKQDLEAKNTQTLTADVKDNEIIEQQRKIFSLIQEKNELQQMLESVIAEKEQLKTDLKEN 1076
Query: 84 SDEALERCQILELLNAELEEKMMQEAEK----LKAQGEYSR----------KLEERFMTL 129
+ +E + L LL EL+++ A++ +K +GE SR KL+E+ L
Sbjct: 1077 IEMTIENQEELRLLGDELKKQQEIVAQEKNHAIKKEGELSRTCDRLAEVEEKLKEKSQQL 1136
Query: 130 AANHELMLRFKDEYKSENIKLRE-ENEKLRLENSSLFSQALKDEEAKVLQLT----VRCE 184
+ +L ++E K+ E EN K L+N L + ++ E ++ Q +
Sbjct: 1137 QEKQQQLLNVQEEMSEMQKKINEIENLKNELKNKELTLEHMETERLELAQKLNENYEEVK 1196
Query: 185 ALTGELETLKE-----RCAQDACQAQAREKELLELQSQQ----ACTHTKETEQLRSQL-- 233
++T E + LKE +D + RE E LQ+++ A H KE ++ +L
Sbjct: 1197 SITKERKVLKELQKSFETERDHLRGYIREIEATGLQTKEELKIAHIHLKEHQETIDELRR 1256
Query: 234 ------------QTLKQQH-------------QQAVEQIAKAEETHSSLSQELQARLQTV 268
Q L++ H Q+ + + + ET ++++ Q+
Sbjct: 1257 SVSEKTAQIINTQDLEKSHTKLQEEIPVLHEEQELLPNVKEVSETQETMNELELLTEQST 1316
Query: 269 TREKEELLQLSIERGKV---LQNKQAEICQL----------EEKLEIANEDRK----HAL 311
T++ L ++ +ER ++ Q Q EI L +E LE+ ++ K L
Sbjct: 1317 TKDSTTLARIEMERLRLNEKFQESQEEIKSLTKERDNLKTIKEALEVKHDQLKEHIRETL 1376
Query: 312 ERFEQEAVAVDSNLRVRELQRKVDGIQKAYDELRLQSEAFKKHSLDLLSKEREL 365
+ ++ + +L ++E + I ++ + + A + +++L + L
Sbjct: 1377 AKIQESQSKQEQSLNMKEKDNETTKIVSEMEQFKPKDSALLRIEIEMLGLSKRL 1430
Score = 57.4 bits (137), Expect = 2e-08
Identities = 71/355 (20%), Positives = 163/355 (45%), Gaps = 39/355 (10%)
Query: 20 EERLEKQNEKLNNQEEETEFKELDGLREALANLRGLSEEERSEKAMLRSRIEEQSQLICI 79
EE L+ + ++L +ET+ ++L+ +++ L R LS+E + LR +I E++ I
Sbjct: 1898 EETLKLERDQLKESLQETKARDLE-IQQELKTARMLSKEHKETVDKLREKISEKTIQISD 1956
Query: 80 LKRRSDEALERCQILELLNAELEEKMMQEAEKLKAQGEYSRKLEERFMTLAANHELMLRF 139
+++ D++ + Q K +QE +K + Q R E+ M+ +E M +
Sbjct: 1957 IQKDLDKSKDELQ-----------KKIQELQKKELQ--LLRVKEDVNMSHKKINE-MEQL 2002
Query: 140 KDEYKSENIKLREENEKLRLENSSLFSQALKD-EEAKVLQLTVRCEALTGELETLKERCA 198
K +++++N+ + + +R++N L + + EE +++ EL +KE
Sbjct: 2003 KKQFEAQNLSM----QSVRMDNFQLTKKLHESLEEIRIVAKE------RDELRRIKESLK 2052
Query: 199 QDACQAQAREKELLELQSQQACTHTKETEQLRSQLQTLKQQHQQAVEQIAKAEETHSSLS 258
+ Q A +E++ ++ Q++ + + L Q E + + S
Sbjct: 2053 MERDQFIATLREMI--------ARDRQNHQVKPEKRLLSDGQQHLTESLREK----CSRI 2100
Query: 259 QELQARLQTVTREKEELLQLSIERGKVLQNKQAEICQLEEKLEIANEDRKHALERFE-QE 317
+EL R + E L +LS++ K ++ ++ +++ L + KH + F +
Sbjct: 2101 KELLKRYSEMDDHYECLNRLSLDLEKEIEFQKELSMRVKANLSLPYLQTKHIEKLFTANQ 2160
Query: 318 AVAVDSNLRVRELQRKVDGIQKAYDELRLQSEAFKKHSLDLLSKERELNGKLRHL 372
+++ + +++L+ + + K +E F+ +D + K++EL K++HL
Sbjct: 2161 RCSMEFHRIMKKLKYVLSYVTKIKEEQHESINKFEMDFIDEVEKQKELLIKIQHL 2215
Score = 55.8 bits (133), Expect = 6e-08
Identities = 72/376 (19%), Positives = 168/376 (44%), Gaps = 50/376 (13%)
Query: 35 EETEFKELDGLREALANLRGLSEEERSEKAMLRSRIEEQSQLIC----ILKRRSDEALER 90
EET E D L+E L E++ E ++ ++E + I I+ +++E
Sbjct: 1695 EETLKVERDQLKENLRETITRDLEKQEELKIVHMHLKEHQETIDKLRGIVSEKTNEISNM 1754
Query: 91 CQILELLNAELEEKMMQEAEKLKAQGEYSRKLEERFMTL----AANHELMLRFKDEYKSE 146
+ LE N L+ + ++ E+L+ + ++ +E L + + + + + ++
Sbjct: 1755 QKDLEHSNDALKAQDLKIQEELRIAHMHLKEQQETIDKLRGIVSEKTDKLSNMQKDLENS 1814
Query: 147 NIKLREENEKLRLENSSLFS--QALKDEEAKVLQLTVRCEALTGELETLKERCAQDACQA 204
N KL+E+ ++L+ L + + + + + KV ++ + + + TL + ++ A
Sbjct: 1815 NAKLQEKIQELKANEHQLITLKKDVNETQKKVSEMEQLKKQIKDQSLTLSKLEIENLNLA 1874
Query: 205 QAREKELLELQSQQACTHTKETEQLRSQLQTLKQQHQQAVEQIAKAEETHSSLSQELQ-A 263
Q + L E++S KE + LR +TLK + Q E + + + + QEL+ A
Sbjct: 1875 QKLHENLEEMKSVM-----KERDNLRRVEETLKLERDQLKESLQETKARDLEIQQELKTA 1929
Query: 264 RL------QTVTREKEELLQLSIERGKV-----------------LQNKQAEICQLEEKL 300
R+ +TV + +E++ + +I+ + LQ K+ ++ +++E +
Sbjct: 1930 RMLSKEHKETVDKLREKISEKTIQISDIQKDLDKSKDELQKKIQELQKKELQLLRVKEDV 1989
Query: 301 EIANE--------DRKHALERFEQEAVAVDSNLRVRELQRKVDGIQ---KAYDELRLQSE 349
++++ ++ + ++V +D+ ++L ++ I+ K DELR E
Sbjct: 1990 NMSHKKINEMEQLKKQFEAQNLSMQSVRMDNFQLTKKLHESLEEIRIVAKERDELRRIKE 2049
Query: 350 AFKKHSLDLLSKEREL 365
+ K ++ RE+
Sbjct: 2050 SLKMERDQFIATLREM 2065
Score = 52.8 bits (125), Expect = 5e-07
Identities = 80/373 (21%), Positives = 161/373 (43%), Gaps = 49/373 (13%)
Query: 21 ERLEKQNEKLNNQEEETEFKELDGLREALANLRGLSEEERSEKAM-LRSRIEEQSQLICI 79
E E+ N+++ N +E + + D AL +E EK ++ R+ E QL
Sbjct: 838 EENERMNQEIVNLSKEAQ--KFDSSLGALKTELSYKTQELQEKTREVQERLNEMEQLKEQ 895
Query: 80 LKRRSDEALERCQILELLNAELEEKMMQEAEKLKAQGEYSRKLEERFMTLAANHELMLRF 139
L+ R D L Q +E + EK+ Q E++K + L++ +L + +
Sbjct: 896 LENR-DSTL---QTVEREKTLITEKLQQTLEEVKTLTQEKDDLKQLQESLQIERDQLKSD 951
Query: 140 KDEYKSENI----KLREENEKLRLENSSLFSQALKDEEAKVLQLTVRCEALTGEL----- 190
+ + NI +LR E L+ ++ LK + ++ + + E TGE
Sbjct: 952 IHDTVNMNIDTQEQLRNALESLKQHQETI--NTLKSKISEEVSRNLHMEENTGETKDEFQ 1009
Query: 191 ---------ETLKERCAQDACQAQAREKELLELQSQQACTHTKETEQLRSQLQT------ 235
+ L+ + Q A ++ E++E Q ++ + +E +L+ L++
Sbjct: 1010 QKMVGIDKKQDLEAKNTQ-TLTADVKDNEIIE-QQRKIFSLIQEKNELQQMLESVIAEKE 1067
Query: 236 -LKQQHQQAVEQIAKAEETHSSLSQELQARLQTVTREKEELLQLSIERGKVLQNKQAEIC 294
LK ++ +E + +E L EL+ + + V +EK +I++ L +
Sbjct: 1068 QLKTDLKENIEMTIENQEELRLLGDELKKQQEIVAQEKNH----AIKKEGELSRTCDRLA 1123
Query: 295 QLEEKLEIANEDRKHALERFEQEAVAVDSNLRVRELQRKVDGIQKAYDELR---LQSEAF 351
++EEKL +++ L+ +Q+ + V + E+Q+K++ I+ +EL+ L E
Sbjct: 1124 EVEEKL----KEKSQQLQEKQQQLLNVQEEM--SEMQKKINEIENLKNELKNKELTLEHM 1177
Query: 352 KKHSLDLLSKERE 364
+ L+L K E
Sbjct: 1178 ETERLELAQKLNE 1190
Score = 50.4 bits (119), Expect = 3e-06
Identities = 76/345 (22%), Positives = 141/345 (40%), Gaps = 65/345 (18%)
Query: 20 EERLEKQNEKLNNQEEETEFKELDGLREALANLRGLSEEERSEKAMLRSRIEEQSQLICI 79
E ++ ++LN + EE E LRE + L L SE LR I+++S+ + I
Sbjct: 719 EGKITDLQKELNKEVEENE-----ALREEVILLSELKSLP-SEVERLRKEIQDKSEELHI 772
Query: 80 LKRRSDEALERCQILELLNAELEEKMMQEAEKLKAQGEYSRKLEERFMTLAANHELMLRF 139
+ D+ E L E++ + + L + ++ F H + F
Sbjct: 773 ITSEKDKLFSEVVHKESRVQGLLEEIGKTKDDLATTQSNYKSTDQEFQNFKTLH---MDF 829
Query: 140 KDEYKSENIKLREENEKLRLENSSLFSQALKDEEAKVLQLTVRCEALTGELETLKERCAQ 199
+ +YK + EENE++ E +L +A K + + G L+T
Sbjct: 830 EQKYKM----VLEENERMNQEIVNLSKEAQKFDSS------------LGALKTE------ 867
Query: 200 DACQAQAREKELLELQSQQACTHTKETEQLRSQLQTLKQQHQQAVEQIAKAEETHSSLSQ 259
L ++Q+ T+E ++ ++++ LK+Q + + E + +++
Sbjct: 868 ------------LSYKTQELQEKTREVQERLNEMEQLKEQLENRDSTLQTVEREKTLITE 915
Query: 260 ELQARLQ---TVTREKEELLQ----LSIERGKVLQNKQAEI---CQLEEKLEIANEDRKH 309
+LQ L+ T+T+EK++L Q L IER ++ + + +E+L A E K
Sbjct: 916 KLQQTLEEVKTLTQEKDDLKQLQESLQIERDQLKSDIHDTVNMNIDTQEQLRNALESLKQ 975
Query: 310 ALERF----EQEAVAVDSNLRVR--------ELQRKVDGIQKAYD 342
E + + V NL + E Q+K+ GI K D
Sbjct: 976 HQETINTLKSKISEEVSRNLHMEENTGETKDEFQQKMVGIDKKQD 1020
Score = 49.3 bits (116), Expect = 6e-06
Identities = 74/346 (21%), Positives = 137/346 (39%), Gaps = 43/346 (12%)
Query: 29 KLNNQEEETEFKELDGLREALANLRGLSEEERSEKAMLRSRIEEQSQL----ICILKRRS 84
KL NQE EL+ LR NL E+ R+EK + +++E++ L K +
Sbjct: 489 KLLNQENIES--ELNSLRADYDNLVLDYEQLRTEKEEMELKLKEKNDLDEFEALERKTKK 546
Query: 85 DEALERCQIL----------ELLNAELEEKMMQEAEKLKAQGEYSRKLEERFMTLAANHE 134
D+ ++ + E+ N +LE ++ + E L+ + + +KL+E
Sbjct: 547 DQEMQLIHEISNLKNLVKHAEVYNQDLENELSSKVELLREKEDQIKKLQE---------- 596
Query: 135 LMLRFKDEYKSENIKLREENEKLRLENSSLFSQALKDEEAKVLQLTVRCEALTGELETLK 194
+ D K ENIK+ +E+ Q L D E L L E LK
Sbjct: 597 ----YIDSQKLENIKMDLSYSLESIEDPKQMKQTLFDAETVALDAKRESAFLRSENLELK 652
Query: 195 ERCAQDACQAQAREKELLELQSQQACTHTKETEQLRSQLQTLKQQHQQAVEQIAKAEETH 254
E+ + A + E ++ QSQ + + L +LQ+ + + I
Sbjct: 653 EKMKELATTYKQMENDIQLYQSQLEAKKKMQVD-LEKELQSAFNEITKLTSLIDGKVPKD 711
Query: 255 SSLSQELQARLQTVTREKEELLQLSIERGKVLQNKQAEICQLE------EKLEIANEDRK 308
+ EL+ ++ + +E L +E + L+ + + +L+ E+L +D+
Sbjct: 712 LLCNLELEGKITDLQKE----LNKEVEENEALREEVILLSELKSLPSEVERLRKEIQDKS 767
Query: 309 HALERFEQEAVAVDSNLRVRE--LQRKVDGIQKAYDELRLQSEAFK 352
L E + S + +E +Q ++ I K D+L +K
Sbjct: 768 EELHIITSEKDKLFSEVVHKESRVQGLLEEIGKTKDDLATTQSNYK 813
Score = 41.2 bits (95), Expect = 0.002
Identities = 75/368 (20%), Positives = 156/368 (42%), Gaps = 56/368 (15%)
Query: 25 KQNEKL--NNQEEETEFKEL-DGLREALANLRGLSEEERSEKAMLR----SRIEEQSQLI 77
K EKL NQ EF + L+ L+ + + EE+ +E+Q +L+
Sbjct: 2150 KHIEKLFTANQRCSMEFHRIMKKLKYVLSYVTKIKEEQHESINKFEMDFIDEVEKQKELL 2209
Query: 78 CILKRRSDEALERCQI--LELLNAELEEKM---MQEAEKLKAQGEYSRKLEERFMTLAAN 132
++ + C + EL + +L + M ++E K ++ E+ ++ F + +N
Sbjct: 2210 IKIQHLQQD----CDVPSRELRDLKLNQNMDLHIEEILKDFSESEFP-SIKTEFQQVLSN 2264
Query: 133 HELMLRFKDEYKS-----ENIK--LREENEKLRLENSSLFSQAL---------------- 169
+ M +F +E+ + E +K +++EN+++ N+ ++ +
Sbjct: 2265 RKEMTQFLEEWLNTRFDIEKLKNGIQKENDRICQVNNFFNNRIIAIMNESTEFEERSATI 2324
Query: 170 -KDEEAKVLQLTVRCEALTGELETLKERCAQDA-CQAQAREKELLELQSQQACTHTKETE 227
K+ E + L + E L +TLK A A ++ + + S+ T++
Sbjct: 2325 SKEWEQDLKSLKEKNEKLFKNYQTLKTSLASGAQVNPTTQDNKNPHVTSRATQLTTEKIR 2384
Query: 228 QLRSQLQTLKQQHQQAVEQIAKAEETHSSLSQELQARLQTVTREKEELLQLSIERGKVLQ 287
+L + L K+ +I K ++ ++ ++ A+LQ E + L+ + E +VLQ
Sbjct: 2385 ELENSLHEAKESAMHKESKIIKMQK-ELEVTNDIIAKLQAKVHESNKCLEKTKETIQVLQ 2443
Query: 288 NKQA--------EICQLEEKLEIANEDRKHALERFEQEAVAVDSNLR-----VRELQRKV 334
+K A EI L+ KL + ++ + FE+E A + + +R L+ +
Sbjct: 2444 DKVALGAKPYKEEIEDLKMKLVKIDLEKMKNAKEFEKEISATKATVEYQKEVIRLLRENL 2503
Query: 335 DGIQKAYD 342
Q+A D
Sbjct: 2504 RRSQQAQD 2511
Score = 34.7 bits (78), Expect = 0.14
Identities = 68/382 (17%), Positives = 151/382 (39%), Gaps = 42/382 (10%)
Query: 15 DTPPPEERLEKQNEKLNNQEEE--------------TEFKELDGLREALANLRGLSEEER 60
D P E R K N+ ++ EE TEF+++ R+ + R
Sbjct: 2220 DVPSRELRDLKLNQNMDLHIEEILKDFSESEFPSIKTEFQQVLSNRKEMTQFLEEWLNTR 2279
Query: 61 SEKAMLRSRIEEQSQLIC----ILKRRSDEALERCQILELLNAELEEKMMQEAEKLKAQG 116
+ L++ I++++ IC R + E +A + ++ Q+ + LK +
Sbjct: 2280 FDIEKLKNGIQKENDRICQVNNFFNNRIIAIMNESTEFEERSATISKEWEQDLKSLKEKN 2339
Query: 117 EYSRKLEERFMTLAANHELMLRFKDEYKSENIKLREEN---EKLRLENSSLFS--QALKD 171
E K + T A+ + + K+ ++ R EK+R +SL ++
Sbjct: 2340 EKLFKNYQTLKTSLASGAQVNPTTQDNKNPHVTSRATQLTTEKIRELENSLHEAKESAMH 2399
Query: 172 EEAKVLQLTVRCEALTGELETLKERCAQDACQAQAREKELLELQSQQAC---THTKETEQ 228
+E+K++++ E + L+ + + + ++ + LQ + A + +E E
Sbjct: 2400 KESKIIKMQKELEVTNDIIAKLQAKVHESNKCLEKTKETIQVLQDKVALGAKPYKEEIED 2459
Query: 229 LRSQLQTLKQQHQQAVEQIAKAEETHSSLSQELQARLQTVTREKEELLQLSIERGKVLQN 288
L+ +L + +E++ A+E +E+ A TV +KE + L + Q
Sbjct: 2460 LKMKLVKID------LEKMKNAKE----FEKEISATKATVEYQKEVIRLLRENLRRSQQA 2509
Query: 289 KQAEICQLEEKLEIANEDRKHALERFEQEAVAVDSNLRVRELQRKVDGIQKAYDELRLQS 348
+ + + +N+ + N + L+ + ++K +L+ Q+
Sbjct: 2510 QDTSVISEHTDPQPSNKPLTCG------GGSGIVQNTKALILKSEHIRLEKEISKLKQQN 2563
Query: 349 EAFKKHSLDLLSKERELNGKLR 370
E K +LLS + L+ +++
Sbjct: 2564 EQLIKQKNELLSNNQHLSNEVK 2585
Score = 29.6 bits (65), Expect = 4.6
Identities = 41/163 (25%), Positives = 74/163 (45%), Gaps = 26/163 (15%)
Query: 34 EEETEFKELDGLREALANLRGLSEEERSEKAMLRSRIEEQSQLICILKRRSDEALERCQI 93
+EE E ++ ++ L ++ E E+ E + ++ +E Q ++I +L+ E L R Q
Sbjct: 2454 KEEIEDLKMKLVKIDLEKMKNAKEFEK-EISATKATVEYQKEVIRLLR----ENLRRSQQ 2508
Query: 94 LELLNAELEEKMMQEAEKLKAQGEYSRKLEERFMTLAANHELMLRFKDEYKSENIKLREE 153
+ + E Q + K G S + N + ++ KSE+I+L +E
Sbjct: 2509 AQDTSVISEHTDPQPSNKPLTCGGGSG--------IVQNTKALI-----LKSEHIRLEKE 2555
Query: 154 NEKLRLENSSLFSQALKDEEAKVLQLTVRCEALTGELETLKER 196
KL+ +N L Q K+E L + L+ E++T KER
Sbjct: 2556 ISKLKQQNEQLIKQ--KNE------LLSNNQHLSNEVKTWKER 2590
>gi|41322923 plectin 1 isoform 11 [Homo sapiens]
Length = 4547
Score = 68.2 bits (165), Expect = 1e-11
Identities = 79/384 (20%), Positives = 167/384 (43%), Gaps = 42/384 (10%)
Query: 7 QKQQAPRMDTPPPEE-----RLEKQNEKLNNQEEETEFKELDGLREALANLRGLSEEERS 61
Q ++A R+ E+ + + EKL + E+ + + AL + E
Sbjct: 2110 QVEEAERLKQSAEEQAQARAQAQAAAEKLRKEAEQEAARRAQAEQAALRQKQAADAEMEK 2169
Query: 62 EKAMLRSRIEEQSQL---ICILKRRSDEALERCQILELLNAELEEKMMQEAEKLKAQGEY 118
K + +++Q+ + L+ + +E + +L+ EE +AE +A +
Sbjct: 2170 HKKFAEQTLRQKAQVEQELTTLRLQLEETDHQKNLLD------EELQRLKAEATEAARQR 2223
Query: 119 SRKLEERFMTLAANHELM-LRFKDEYKSENIKLREENEKLRLENSSLFSQALKDEEAKVL 177
S+ EE F EL L+ + E ++ + LR++ +N+ F Q ++ +V
Sbjct: 2224 SQVEEELFSVRVQMEELSKLKARIEAENRALILRDK------DNTQRFLQEEAEKMKQVA 2277
Query: 178 QLTVRCEALTGELETLKERCAQDACQAQAREKELLELQSQQACTHTKETEQLRSQLQTLK 237
+ R E L++ +D Q +A +++L+ + Q +E +L+++ + L+
Sbjct: 2278 EEAARLSVAAQEAARLRQLAEEDLAQQRALAEKMLKEKMQAV----QEATRLKAEAELLQ 2333
Query: 238 QQHQQAVEQIAKAEETHSSLSQELQARLQ----TVTREKEELLQLSIERGKVLQNKQAEI 293
QQ + A EQ + +E ++Q+L Q T+ E++ L++S E + L+ + AE+
Sbjct: 2334 QQKELAQEQARRLQEDKEQMAQQLAEETQGFQRTLEAERQRQLEMSAEAER-LKLRVAEM 2392
Query: 294 CQLEEKLEIANE----------DRKHALERFEQEAVAVDSNLRVRELQRKVDG--IQKAY 341
+ + + E + ++ H E QE V + L ++ Q D +++A
Sbjct: 2393 SRAQARAEEDAQRFRKQAEEIGEKLHRTELATQEKVTLVQTLEIQRQQSDHDAERLREAI 2452
Query: 342 DELRLQSEAFKKHSLDLLSKEREL 365
EL + E ++ + L K E+
Sbjct: 2453 AELEREKEKLQQEAKLLQLKSEEM 2476
Score = 65.5 bits (158), Expect = 8e-11
Identities = 88/363 (24%), Positives = 158/363 (43%), Gaps = 33/363 (9%)
Query: 6 LQKQQAPRMDTPPPEERLEKQNEKLNNQEEETEFKELDGLREALANLRGLSEEERSEKAM 65
L++Q+ DT ++E++ L E+ + + L L +R +E+ K
Sbjct: 1906 LERQKGLVEDTLRQRRQVEEEILALKASFEKAAAGKAE-LELELGRIRSNAEDTLRSKEQ 1964
Query: 66 LRSRIEEQSQLICILKRRSDEALERCQILELLNAELE-----EKMMQEAEKLKAQGEYSR 120
Q QL +RR EA ER Q + L AE E + ++E E+LKA+ E +R
Sbjct: 1965 AELEAARQRQLAAEEERRRREAEERVQ--KSLAAEEEAARQRKAALEEVERLKAKVEEAR 2022
Query: 121 KLEERFMTLAANHELMLRFKDEYKSENIKLREENEKLRLENSSLFSQALKDEEAKVLQLT 180
+L ER +A L+ E + ++ E+ ++ Q +E VL
Sbjct: 2023 RLRERAEQESAR---QLQLAQEAAQKRLQAEEKAHAFAVQQKEQELQQTLQQEQSVL--- 2076
Query: 181 VRCEALTGELETLKERCAQDACQAQAREKELLELQSQQACTHTKETEQLRSQLQTLKQQH 240
+ L GE E + R A++A +A+ + E ++ Q+ +E E+L+ Q+ ++Q
Sbjct: 2077 ---DQLRGEAEAAR-RAAEEAEEARVQ----AEREAAQSRRQVEEAERLK---QSAEEQA 2125
Query: 241 QQAVEQIAKAEETHSSLSQELQARLQTVTREKEELLQLSIERGKVLQNKQAEICQLEEKL 300
Q + A AE+ QE R Q E+ L Q ++ ++K+ L +K
Sbjct: 2126 QARAQAQAAAEKLRKEAEQEAARRAQA---EQAALRQKQAADAEMEKHKKFAEQTLRQKA 2182
Query: 301 EIANEDRKHALERFEQEAVAVDSNLRVRELQR-KVDGIQKAYDELRLQSEAFK-KHSLDL 358
++ +++ R + E NL ELQR K + + A +++ E F + ++
Sbjct: 2183 QV---EQELTTLRLQLEETDHQKNLLDEELQRLKAEATEAARQRSQVEEELFSVRVQMEE 2239
Query: 359 LSK 361
LSK
Sbjct: 2240 LSK 2242
Score = 65.1 bits (157), Expect = 1e-10
Identities = 104/371 (28%), Positives = 162/371 (43%), Gaps = 48/371 (12%)
Query: 20 EERLEKQNEKLNNQEEETEFKELDGLREALANLR-GLSEEERSEKAMLRSRIEEQSQLIC 78
++R + E+L Q EE E + E ++ L +RS +A L+S+ ++
Sbjct: 1531 KQRALQALEELRLQAEEAERRLRQAEVERARQVQVALETAQRSAEAELQSKRASFAEKTA 1590
Query: 79 ILKRRSDEALERCQILELLNAELEEKMMQEAEKLKAQGEYSRKLEERFMTLAANHELMLR 138
L+R E E + +L E E + Q+AE +A+ E R+LE L AN L LR
Sbjct: 1591 QLERSLQE--EHVAVAQL-REEAERRAQQQAEAERAREEAERELER--WQLKANEALRLR 1645
Query: 139 FKDEYKSENIKLRE-ENEKLRLENSSLFSQALKDEEAKVLQLTVRCEALTGELETLKERC 197
+ E ++ L + E EK + E + K EE V Q E ELE ++
Sbjct: 1646 LQAEEVAQQKSLAQAEAEKQKEEAEREARRRGKAEEQAVRQR----ELAEQELEKQRQLA 1701
Query: 198 AQDACQAQAREKELLELQSQQACTHTKETEQLRSQLQTLKQQHQQAVEQIAKAEETHSSL 257
A Q A E+EL+ L++ ETEQ +QQ Q E++A+ + ++
Sbjct: 1702 EGTAQQRLAAEQELIRLRA--------ETEQG-------EQQRQLLEEELARLQREAAAA 1746
Query: 258 S---QELQARLQTVTREKEELL----------QLSIERGKVLQNKQAEICQLEEKLEIAN 304
+ QEL+A L V E E LL + + E+ K Q +AE + E E A
Sbjct: 1747 TQKRQELEAELAKVRAEMEVLLASKARAEEESRSTSEKSK--QRLEAEAGRFRELAEEAA 1804
Query: 305 EDRKHALERFEQEAVAVDSNLRVRELQRKV--DGIQKAYDELRLQSEAFKKHSLDLLSKE 362
R A E Q +A + R R +V + + + RL++EA + L KE
Sbjct: 1805 RLRALAEEAKRQRQLAEEDAARQRAEAERVLAEKLAAIGEATRLKTEA----EIALKEKE 1860
Query: 363 RELNGKLRHLS 373
E N +LR L+
Sbjct: 1861 AE-NERLRRLA 1870
Score = 64.3 bits (155), Expect = 2e-10
Identities = 95/355 (26%), Positives = 156/355 (43%), Gaps = 52/355 (14%)
Query: 33 QEEETEFKELDGLREALANLRGLSEEER---SEKAMLR-----SRIEEQSQLICILKRRS 84
QE E E ++ E L + +EEE SEK+ R R E ++ L+ +
Sbjct: 1751 QELEAELAKVRAEMEVLLASKARAEEESRSTSEKSKQRLEAEAGRFRELAEEAARLRALA 1810
Query: 85 DEALERCQILE----LLNAELEEKMMQEAEKLKAQGEYSRKLEERFMTLAANHELMLRFK 140
+EA + Q+ E AE E + AEKL A GE +R L E+ L+ K
Sbjct: 1811 EEAKRQRQLAEEDAARQRAEAERVL---AEKLAAIGEATR--------LKTEAEIALKEK 1859
Query: 141 DEYKSENIKLREENEKLRLENSSLFSQALK---DEEAKVLQLTVRCEALTGELETLKERC 197
+ +EN +LR E + L QA + D E ++ QL +A ELE K
Sbjct: 1860 E---AENERLRRLAEDEAFQRRRLEEQAAQHKADIEERLAQLR---KASDSELERQKGLV 1913
Query: 198 AQDACQAQAREKELLELQS--QQACTHTKETEQLRSQLQTLKQQHQQAVEQIAKAEETHS 255
Q + E+E+L L++ ++A E E ++++ + ++ EQ E +
Sbjct: 1914 EDTLRQRRQVEEEILALKASFEKAAAGKAELELELGRIRSNAEDTLRSKEQ----AELEA 1969
Query: 256 SLSQELQARLQTVTREKEELLQLSIERGKVLQNKQAEICQLEEKLEIANEDRKHALERFE 315
+ ++L A + RE EE +Q S+ + ++ + E+L+ E+ + ER E
Sbjct: 1970 ARQRQLAAEEERRRREAEERVQKSLAAEEEAARQRKAALEEVERLKAKVEEARRLRERAE 2029
Query: 316 QEAVAVDSNLRVRELQRKVDGIQKAYDELRLQSEAFKKHSLDLLSKERELNGKLR 370
QE+ R+LQ + QK RLQ+E K H+ + KE+EL L+
Sbjct: 2030 QES--------ARQLQLAQEAAQK-----RLQAEE-KAHAFAVQQKEQELQQTLQ 2070
Score = 60.1 bits (144), Expect = 3e-09
Identities = 77/343 (22%), Positives = 141/343 (41%), Gaps = 25/343 (7%)
Query: 3 APMLQKQQAPRMDTPPPEERLEKQNEKLNNQEEETEFKELDGLREALANLRGLSEEER-- 60
A + K+ + T E L++++ + EE E + A E ER
Sbjct: 1576 AELQSKRASFAEKTAQLERSLQEEHVAVAQLREEAERRAQQQAEAERAREEAERELERWQ 1635
Query: 61 ---SEKAMLRSRIEEQSQLICILKRRSDEALERCQILELLNAELEEKMMQEAEKLKAQGE 117
+E LR + EE +Q + + +++ E + + EE+ +++ E + + E
Sbjct: 1636 LKANEALRLRLQAEEVAQQKSLAQAEAEKQKEEAEREARRRGKAEEQAVRQRELAEQELE 1695
Query: 118 YSRKLEERF--MTLAANHELM-LRFKDEYKSENIKLREENEKLRLENSSLFSQALKDEEA 174
R+L E LAA EL+ LR + E + +L EE ++ +Q ++ EA
Sbjct: 1696 KQRQLAEGTAQQRLAAEQELIRLRAETEQGEQQRQLLEEELARLQREAAAATQKRQELEA 1755
Query: 175 KVLQLTVRCEALTGELETLKERCAQDACQAQAREKELLELQSQQACTHTKETEQLRSQLQ 234
++ ++ E L K R +++ + K+ LE ++ + +E +LR+ +
Sbjct: 1756 ELAKVRAEMEVLLAS----KARAEEESRSTSEKSKQRLEAEAGRFRELAEEAARLRALAE 1811
Query: 235 TLKQQHQQAVEQIAKAEETHSSLSQELQARLQTVTREKEELLQLSIERGKVLQNKQAEIC 294
K+Q Q A E A+ + E A + TR L E L+ K+AE
Sbjct: 1812 EAKRQRQLAEEDAARQRAEAERVLAEKLAAIGEATR-------LKTEAEIALKEKEAE-- 1862
Query: 295 QLEEKLEIANEDRKHALERFEQEAV--AVDSNLRVRELQRKVD 335
E+L ED R E++A D R+ +L++ D
Sbjct: 1863 --NERLRRLAEDEAFQRRRLEEQAAQHKADIEERLAQLRKASD 1903
Score = 57.8 bits (138), Expect = 2e-08
Identities = 87/372 (23%), Positives = 160/372 (43%), Gaps = 37/372 (9%)
Query: 20 EERLEKQ--NEKLNNQEEETEFKELDGLR---EALANLRGLSEEERS-------EKAMLR 67
EER++K E+ ++ + +E++ L+ E LR +E+E + E A R
Sbjct: 1987 EERVQKSLAAEEEAARQRKAALEEVERLKAKVEEARRLRERAEQESARQLQLAQEAAQKR 2046
Query: 68 SRIEEQSQLICILKRRSD--EALERCQ-ILELLNAELE--EKMMQEAEKLKAQGEYSRKL 122
+ EE++ + ++ + + L++ Q +L+ L E E + +EAE+ + Q E
Sbjct: 2047 LQAEEKAHAFAVQQKEQELQQTLQQEQSVLDQLRGEAEAARRAAEEAEEARVQAEREAAQ 2106
Query: 123 EERFMTLAANHELMLRFKDEYKSENIKLREENEKLRLENSSLFSQALKDEEAKVLQLTVR 182
R + A E + + +E + + EKLR E ++ + E+A + Q
Sbjct: 2107 SRRQVEEA---ERLKQSAEEQAQARAQAQAAAEKLRKEAEQEAARRAQAEQAALRQK--- 2160
Query: 183 CEALTGELETLKERCAQDACQAQAREKELLELQSQ-QACTHTKETEQLRSQLQTLKQQHQ 241
+A E+E K+ Q Q E+EL L+ Q + H K L +LQ LK +
Sbjct: 2161 -QAADAEMEKHKKFAEQTLRQKAQVEQELTTLRLQLEETDHQKNL--LDEELQRLKAEAT 2217
Query: 242 QAVEQIAKAEETHSSLSQELQARLQTVTREKEELLQLSIERGKVLQNKQAEICQLEEKLE 301
+A Q ++ EE S+ +++ + R + E R +L++K L+E+ E
Sbjct: 2218 EAARQRSQVEEELFSVRVQMEELSKLKARIEAE------NRALILRDKDNTQRFLQEEAE 2271
Query: 302 IANEDRKHALERFEQEAVAVDSNLRVRELQRKVDGIQKAYDELRLQSEAFKKHSLDLLSK 361
K E + +VA R+R+L + Q+A E L+ + L
Sbjct: 2272 ----KMKQVAEEAARLSVAAQEAARLRQLAEEDLAQQRALAEKMLKEKMQAVQEATRLKA 2327
Query: 362 ERELNGKLRHLS 373
E EL + + L+
Sbjct: 2328 EAELLQQQKELA 2339
Score = 57.8 bits (138), Expect = 2e-08
Identities = 74/339 (21%), Positives = 149/339 (43%), Gaps = 40/339 (11%)
Query: 23 LEKQNEKLNNQEEETEFKELDGLREALANLRGLSEEERSE-KAMLRSRIEEQSQLICILK 81
L+++ EK+ EE L + A LR L+EE+ ++ +A+ ++E+ Q +
Sbjct: 2266 LQEEAEKMKQVAEEAA--RLSVAAQEAARLRQLAEEDLAQQRALAEKMLKEKMQAVQEAT 2323
Query: 82 RRSDEALERCQILELLNAE---LEEKMMQEAEKLKAQGE-YSRKLE---ERFMTLAANHE 134
R EA Q EL + L+E Q A++L + + + R LE +R + ++A E
Sbjct: 2324 RLKAEAELLQQQKELAQEQARRLQEDKEQMAQQLAEETQGFQRTLEAERQRQLEMSAEAE 2383
Query: 135 LMLRFKDEYKSENIKLREENEKLRLENSSLFSQ------ALKDEEAKVLQLTVRCEALTG 188
+ E + E+ ++ R + + + A +++ V L ++ +
Sbjct: 2384 RLKLRVAEMSRAQARAEEDAQRFRKQAEEIGEKLHRTELATQEKVTLVQTLEIQRQQSDH 2443
Query: 189 ELETLKERCAQDACQAQAREKELLELQSQQACTHTKETEQLRSQLQTLKQ---------- 238
+ E L+E A+ + + ++E LQ + T + EQL + Q L+Q
Sbjct: 2444 DAERLREAIAELEREKEKLQQEAKLLQLKSEEMQTVQQEQLLQETQALQQSFLSEKDSLL 2503
Query: 239 -------QHQQAVEQIAKAEETHSSLSQELQARLQTVTREKEELLQLSIERGKVLQNKQA 291
Q + +EQ+ + E + +E Q R Q ++ + L S+E + Q++
Sbjct: 2504 QRERFIEQEKAKLEQLFQDEVAKAQQLREEQQRQQQQMEQERQRLVASMEEARRRQHEAE 2563
Query: 292 E-ICQLEEKLEIANEDRKHALERFEQEAVAVDSNLRVRE 329
E + + +E+L+ + R+ +QE + + N R+RE
Sbjct: 2564 EGVRRKQEELQQLEQQRR------QQEELLAEENQRLRE 2596
Score = 53.1 bits (126), Expect = 4e-07
Identities = 84/360 (23%), Positives = 144/360 (40%), Gaps = 51/360 (14%)
Query: 7 QKQQAPRMDTPPPEERLEKQNEKLNNQEEETEFKELDGLREALANLRGLSEEERSEKA-- 64
Q Q +T + LE + ++ E E +L + A R + +R K
Sbjct: 2352 QMAQQLAEETQGFQRTLEAERQRQLEMSAEAERLKLRVAEMSRAQARAEEDAQRFRKQAE 2411
Query: 65 -----MLRSRIEEQS-----QLICILKRRSDEALERCQILELLNAELE---EKMMQEAEK 111
+ R+ + Q Q + I +++SD ER L AELE EK+ QEA+
Sbjct: 2412 EIGEKLHRTELATQEKVTLVQTLEIQRQQSDHDAER---LREAIAELEREKEKLQQEAKL 2468
Query: 112 LKAQGEYSRKLEERFMTLAANHELMLRFKDEYKSENIKLRE---ENEKLRLENSSLFSQA 168
L+ + E + +++ + L L F E +++ RE E EK +LE Q
Sbjct: 2469 LQLKSEEMQTVQQEQL-LQETQALQQSFLSE--KDSLLQRERFIEQEKAKLE------QL 2519
Query: 169 LKDEEAKVLQLTVRCEALTGELETLKERCAQDACQAQAREKELLELQSQQACTHTKETEQ 228
+DE AK QL + ++E ++R +A+ R+ E E +
Sbjct: 2520 FQDEVAKAQQLREEQQRQQQQMEQERQRLVASMEEARRRQHEAEE-----------GVRR 2568
Query: 229 LRSQLQTLKQQHQQAVEQIAKAEETHSSLSQELQARLQTVTREKEELLQLSIERGKVLQN 288
+ +LQ L+QQ +Q E +A+ + Q L+ + + EE+ + K L N
Sbjct: 2569 KQEELQQLEQQRRQQEELLAEENQRLREQLQLLEEQHRAALAHSEEVTASQVAATKTLPN 2628
Query: 289 KQAEI----CQLEEKLEIANEDRKHALERFEQEAVAVDSNLRVRELQRKVDGIQKAYDEL 344
+ + + E + RK + +R ++ + L ELQR G DEL
Sbjct: 2629 GRDALDGPAAEAEPEHSFDGLRRKVSAQRLQEAGI-----LSAEELQRLAQG-HTTVDEL 2682
Score = 48.5 bits (114), Expect = 1e-05
Identities = 67/305 (21%), Positives = 135/305 (44%), Gaps = 23/305 (7%)
Query: 56 SEEERSEKAMLRSRIEEQSQLICILKRRSDEALERCQILELLNAELEEKMMQEAEKLKAQ 115
SE E LR+ E + L + E L R + E L + + + +++A
Sbjct: 1309 SESVIQEYVDLRTHYSELTTLTSQYIKFISETLRRMEEEERLAEQQRAEERERLAEVEAA 1368
Query: 116 GEYSRKLEERFMTLAANHELMLRFKDEYKSENIKLREENEKLRLENSSLFSQALKDE-EA 174
E R+L E A + E +++ ++ R + E +R E +++ +Q K +
Sbjct: 1369 LEKQRQLAEAHAQAKA--------QAEREAKELQQRMQEEVVRREEAAVDAQQQKRSIQE 1420
Query: 175 KVLQLTVRCEALTGELETLKERCAQDACQAQAREKELLELQSQQACTHTKETEQLRSQLQ 234
++ QL EA E++ K R A+ A +++ R +E + + Q ++ +LQ
Sbjct: 1421 ELQQLRQSSEA---EIQA-KARQAEAAERSRLRIEEEIRVVRLQLEATERQRGGAEGELQ 1476
Query: 235 TLKQQHQQAVEQIAKAEETHSSLSQELQARLQTVTREKEELLQLSIERGKVLQNKQAEIC 294
L+ + ++A Q +A+E L +++Q Q + + EL + + KQ +
Sbjct: 1477 ALRARAEEAEAQKRQAQEEAERLRRQVQDESQRKRQAEVELASRVKAEAEAAREKQRALQ 1536
Query: 295 QLEEKLEIANEDRKHALERFEQEAVAVDSNLRVRELQRKVDGIQKAYD-ELRLQSEAFKK 353
LEE L + E+ + L + E E R R++Q ++ Q++ + EL+ + +F +
Sbjct: 1537 ALEE-LRLQAEEAERRLRQAEVE--------RARQVQVALETAQRSAEAELQSKRASFAE 1587
Query: 354 HSLDL 358
+ L
Sbjct: 1588 KTAQL 1592
Score = 34.7 bits (78), Expect = 0.14
Identities = 83/343 (24%), Positives = 138/343 (40%), Gaps = 53/343 (15%)
Query: 53 RGLSEEERSEKAMLRSRIEEQSQLICILKRRSDEALERCQILELLNAELEEKMMQEAEKL 112
+G EE R ++ I E + L+ + R + L L E + AE+
Sbjct: 974 QGAQEESRCQRC-----ISELKDIRLQLEACETRTVHRLR-LPLDKEPARECAQRIAEQQ 1027
Query: 113 KAQGEYSRKLEERFMTLAANHELMLRFKDEYKSENIKLREENEKL--RLENSSLFSQALK 170
KAQ E L + L+A E +L + + LR E E +LE S A+
Sbjct: 1028 KAQAEVEG-LGKGVARLSAEAEKVLALPEPSPAAPT-LRSELELTLGKLEQVRSLS-AIY 1084
Query: 171 DEEAKVLQLTVRC-----EALTGELETLKERCAQDACQAQAREKELLELQSQQACTHTKE 225
E+ K + L +R E L E LKE AQA L EL++ +A
Sbjct: 1085 LEKLKTISLVIRGTQGAEEVLRAHEEQLKE--------AQAVPATLPELEATKA-----S 1131
Query: 226 TEQLRSQLQTLKQQHQQAVEQIAKAEETHSSLSQELQARLQTVTREKEELLQLSIERGKV 285
++LR+Q + + +++ A+E L Q R V R +E + QL +ER +
Sbjct: 1132 LKKLRAQAEAQQPTFDALRDELRGAQEVGERLQQRHGERDVEVERWRERVAQL-LERWQA 1190
Query: 286 L----QNKQAEICQLEEKLEIANEDR-------KHALERFEQ-------EAVAVDSNLR- 326
+ +Q E+ QL +L E + A R EQ ++ AV LR
Sbjct: 1191 VLAQTDVRQRELEQLGRQLRYYRESADPLGAWLQDARRRQEQIQAMPLADSQAVREQLRQ 1250
Query: 327 ----VRELQRKVDGIQKAYDELRLQSEAFKKHSLDLLSKEREL 365
+ E++R + +++ + A K + L L++ + +L
Sbjct: 1251 EQALLEEIERHGEKVEECQRFAKQYINAIKDYELQLVTYKAQL 1293
Database: hs.faa
Posted date: Aug 4, 2009 4:42 PM
Number of letters in database: 18,247,518
Number of sequences in database: 37,866
Lambda K H
0.310 0.125 0.321
Gapped
Lambda K H
0.267 0.0410 0.140
Matrix: BLOSUM62
Gap Penalties: Existence: 11, Extension: 1
Number of Hits to DB: 12,762,791
Number of Sequences: 37866
Number of extensions: 579045
Number of successful extensions: 11416
Number of sequences better than 10.0: 30
Number of HSP's better than 10.0 without gapping: 349
Number of HSP's successfully gapped in prelim test: 1025
Number of HSP's that attempted gapping in prelim test: 4375
Number of HSP's gapped (non-prelim): 4035
length of query: 374
length of database: 18,247,518
effective HSP length: 104
effective length of query: 270
effective length of database: 14,309,454
effective search space: 3863552580
effective search space used: 3863552580
T: 11
A: 40
X1: 16 ( 7.2 bits)
X2: 38 (14.6 bits)
X3: 64 (24.7 bits)
S1: 42 (21.8 bits)
S2: 63 (28.9 bits)
Search results were obtained with NCBI BLAST and RefSeq entries.
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Guide to the Human Genome
Copyright © 2010 by Stewart Scherer. All rights reserved.