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Search of human proteins with 22749217
BLASTP 2.2.11 [Jun-05-2005]
Reference: Altschul, Stephen F., Thomas L. Madden, Alejandro A. Schaffer,
Jinghui Zhang, Zheng Zhang, Webb Miller, and David J. Lipman (1997),
"Gapped BLAST and PSI-BLAST: a new generation of protein database search
programs", Nucleic Acids Res. 25:3389-3402.
Query= gi|22749217 coiled-coil domain containing 63 [Homo sapiens]
(563 letters)
Database: hs.faa
37,866 sequences; 18,247,518 total letters
Searching..................................................done
Score E
Sequences producing significant alignments: (bits) Value
gi|22749217 coiled-coil domain containing 63 [Homo sapiens] 1090 0.0
gi|215599324 coiled-coil domain containing 114 isoform 2 [Homo s... 171 1e-42
gi|62243484 sarcoma antigen NY-SAR-41 [Homo sapiens] 69 1e-11
gi|156104908 myosin heavy chain 6 [Homo sapiens] 68 2e-11
gi|38045898 RAB6-interacting protein 2 isoform epsilon [Homo sap... 67 6e-11
gi|6715600 golgi autoantigen, golgin subfamily a, 4 [Homo sapiens] 66 7e-11
gi|239745089 PREDICTED: golgi autoantigen, golgin subfamily a-li... 65 2e-10
gi|31563507 GRIP and coiled-coil domain-containing 2 [Homo sapiens] 63 6e-10
gi|221219020 NYD-SP11 protein [Homo sapiens] 63 6e-10
gi|38045896 RAB6-interacting protein 2 isoform delta [Homo sapiens] 63 6e-10
gi|50897852 coiled-coil domain containing 88A isoform 2 [Homo sa... 63 6e-10
gi|34577114 cytomatrix protein p110 [Homo sapiens] 63 6e-10
gi|14165274 golgi-associated microtubule-binding protein HOOK3 [... 62 1e-09
gi|41406064 myosin, heavy polypeptide 10, non-muscle [Homo sapiens] 62 1e-09
gi|4885399 structural maintenance of chromosomes 3 [Homo sapiens] 61 2e-09
gi|239756241 PREDICTED: golgi autoantigen, golgin subfamily a-li... 61 3e-09
gi|55770834 centromere protein F [Homo sapiens] 61 3e-09
gi|71061468 centromere protein E [Homo sapiens] 60 4e-09
gi|208022632 coiled-coil domain containing 88A isoform 1 [Homo s... 60 7e-09
gi|13124879 smooth muscle myosin heavy chain 11 isoform SM1A [Ho... 60 7e-09
gi|92091586 smooth muscle myosin heavy chain 11 isoform SM1B [Ho... 60 7e-09
gi|92091583 smooth muscle myosin heavy chain 11 isoform SM2B [Ho... 60 7e-09
gi|13124875 smooth muscle myosin heavy chain 11 isoform SM2A [Ho... 60 7e-09
gi|31982906 cingulin-like 1 [Homo sapiens] 59 1e-08
gi|22538387 A-kinase anchor protein 9 isoform 2 [Homo sapiens] 59 2e-08
gi|31542634 filamin A interacting protein 1 [Homo sapiens] 59 2e-08
gi|41872583 Rho-associated, coiled-coil containing protein kinas... 58 2e-08
gi|16262452 cingulin [Homo sapiens] 58 2e-08
gi|150010558 myosin, heavy polypeptide 15 [Homo sapiens] 58 2e-08
gi|222418637 golgi autoantigen, golgin subfamily a-like [Homo sa... 58 3e-08
>gi|22749217 coiled-coil domain containing 63 [Homo sapiens]
Length = 563
Score = 1090 bits (2820), Expect = 0.0
Identities = 563/563 (100%), Positives = 563/563 (100%)
Query: 1 MSVLKKNRRKDSDTPQEPSEKAKEQQAEAELRKLRQQFRKMVESRKSFKFRNQQKIASQY 60
MSVLKKNRRKDSDTPQEPSEKAKEQQAEAELRKLRQQFRKMVESRKSFKFRNQQKIASQY
Sbjct: 1 MSVLKKNRRKDSDTPQEPSEKAKEQQAEAELRKLRQQFRKMVESRKSFKFRNQQKIASQY 60
Query: 61 KEIKTLKTEQDEITLLLSLMKSSRNMNRSEKNYMELRLLLQTKEDYEALIKSLKVLLAEL 120
KEIKTLKTEQDEITLLLSLMKSSRNMNRSEKNYMELRLLLQTKEDYEALIKSLKVLLAEL
Sbjct: 61 KEIKTLKTEQDEITLLLSLMKSSRNMNRSEKNYMELRLLLQTKEDYEALIKSLKVLLAEL 120
Query: 121 DEKILQMEKKIANQKQIFAKMQEANNPRKLQKQIHILETRLNLVTVHFDKMLTTNAKLRK 180
DEKILQMEKKIANQKQIFAKMQEANNPRKLQKQIHILETRLNLVTVHFDKMLTTNAKLRK
Sbjct: 121 DEKILQMEKKIANQKQIFAKMQEANNPRKLQKQIHILETRLNLVTVHFDKMLTTNAKLRK 180
Query: 181 EIEDLRFEKAAYDNVYQQLQHCLLMEKKTMNLAIEQSSQAYEQRVEAMARMAAMKDRQKK 240
EIEDLRFEKAAYDNVYQQLQHCLLMEKKTMNLAIEQSSQAYEQRVEAMARMAAMKDRQKK
Sbjct: 181 EIEDLRFEKAAYDNVYQQLQHCLLMEKKTMNLAIEQSSQAYEQRVEAMARMAAMKDRQKK 240
Query: 241 DTSQYNLEIRELERLYAHESKLKSFLLVKLNDRNEFEEQAKREEALKAKKHVKKNRGESF 300
DTSQYNLEIRELERLYAHESKLKSFLLVKLNDRNEFEEQAKREEALKAKKHVKKNRGESF
Sbjct: 241 DTSQYNLEIRELERLYAHESKLKSFLLVKLNDRNEFEEQAKREEALKAKKHVKKNRGESF 300
Query: 301 ESYEVAHLRLLKLAESGNLNQLIEDFLAKEEKNFARFTYVTELNNDMEMMHKRTQRIQDE 360
ESYEVAHLRLLKLAESGNLNQLIEDFLAKEEKNFARFTYVTELNNDMEMMHKRTQRIQDE
Sbjct: 301 ESYEVAHLRLLKLAESGNLNQLIEDFLAKEEKNFARFTYVTELNNDMEMMHKRTQRIQDE 360
Query: 361 IILLRSQQKLSHDDNHSVLRQLEDKLRKTTEEADMYESKYGEVSKTLDLLKNSVEKLFKK 420
IILLRSQQKLSHDDNHSVLRQLEDKLRKTTEEADMYESKYGEVSKTLDLLKNSVEKLFKK
Sbjct: 361 IILLRSQQKLSHDDNHSVLRQLEDKLRKTTEEADMYESKYGEVSKTLDLLKNSVEKLFKK 420
Query: 421 INCDATKILVQLGETGKVTDINLPQYFAIIEKKTNDLLLLETYRRILEVEGAEAEIPPPF 480
INCDATKILVQLGETGKVTDINLPQYFAIIEKKTNDLLLLETYRRILEVEGAEAEIPPPF
Sbjct: 421 INCDATKILVQLGETGKVTDINLPQYFAIIEKKTNDLLLLETYRRILEVEGAEAEIPPPF 480
Query: 481 INPFWGGSALLKPPEPIKVIPPVLGADPFSDRLDDVEQPLDHSSLRQLVLDNYILKENRS 540
INPFWGGSALLKPPEPIKVIPPVLGADPFSDRLDDVEQPLDHSSLRQLVLDNYILKENRS
Sbjct: 481 INPFWGGSALLKPPEPIKVIPPVLGADPFSDRLDDVEQPLDHSSLRQLVLDNYILKENRS 540
Query: 541 KEVRGDSLPEKVDDFRSRKKVTM 563
KEVRGDSLPEKVDDFRSRKKVTM
Sbjct: 541 KEVRGDSLPEKVDDFRSRKKVTM 563
>gi|215599324 coiled-coil domain containing 114 isoform 2 [Homo
sapiens]
Length = 670
Score = 171 bits (434), Expect = 1e-42
Identities = 116/431 (26%), Positives = 229/431 (53%), Gaps = 12/431 (2%)
Query: 41 MVESRKSFKFRNQQKIASQYKEIKTLKTEQDEITLLLSLMKSSRNMNRSEKNYMELRLLL 100
M R+++ Q+I Q +EI+ L+ + ++ + +S ++ R + + LL
Sbjct: 1 MEGERRAYSKEVHQRINKQLEEIRRLEEVRGDLQVQISAAQNQVKRLRDSQRLENMDRLL 60
Query: 101 QTKEDYEALIKSLKVLLAELDEKILQMEKKI-ANQKQIFAKMQEANNPRKLQKQIHILET 159
+ + +A I+ L+ LD++I + E +I + K + + + K++++I ILE
Sbjct: 61 KGRAQVQAEIEELQEQTRALDKQIQEWETRIFTHSKNVRSPGFILDQKVKIRRRIRILEN 120
Query: 160 RLNLVTVHFDKMLTTNAKLRKEIEDLRFEKAAYDNVYQQLQHCLLMEKKTMNLAIEQSSQ 219
+L+ VT HFD L NA LR+E++ LR ++ Y NV ++L+ + ++ I S+
Sbjct: 121 QLDRVTCHFDNQLVRNAALREELDLLRIDRNRYLNVDRKLKKEIHHLHHLVSTLILSSTS 180
Query: 220 AYEQRVEAMARMAAMKDRQKKDTSQYNLEIRELERLYAHESKLKSFLLVKLNDRN---EF 276
AY R EA A+M +++R +K+ +Q +E + L+R H +L FL +K NDR +
Sbjct: 181 AYAVREEAKAKMGLLRERAEKEEAQSEMEAQVLQRQILHLEQLHHFLKLKNNDRQPDPDV 240
Query: 277 EEQAKREEALKAKKHVKKNRGESFESYEVAHLRLLKLAESGNLNQLIEDFLAKEEKNFAR 336
E+ +++ A+ K ++ YE A +L +L + + L++ +L EE+NFA
Sbjct: 241 LEKREKQAGEVAEGVWKTSQERLVLCYEDALNKLSQLMGESDPDLLVQKYLEIEERNFAE 300
Query: 337 FTYVTELNNDMEMMHKRTQRIQDEIILLRSQQKLSHDDNHSVLRQ----LEDKLRKTTEE 392
F ++ E N ++E + + + +Q+ ++ R+ S DD H + Q L+ ++ K E
Sbjct: 301 FNFINEQNLELEHVQEEIKEMQEALVSARA----SKDDQHLLQEQQQKVLQQRMDKVHSE 356
Query: 393 ADMYESKYGEVSKTLDLLKNSVEKLFKKINCDATKILVQLGETGKVTDINLPQYFAIIEK 452
A+ E+++ +V L+ LK ++ LF K +CD++ I LG + D ++ + ++IEK
Sbjct: 357 AERLEARFQDVRGQLEKLKADIQLLFTKAHCDSSMIDDLLGVKTSMGDRDMGLFLSLIEK 416
Query: 453 KTNDLLLLETY 463
+ +LL ++ +
Sbjct: 417 RLVELLTVQAF 427
>gi|62243484 sarcoma antigen NY-SAR-41 [Homo sapiens]
Length = 1417
Score = 68.9 bits (167), Expect = 1e-11
Identities = 108/502 (21%), Positives = 214/502 (42%), Gaps = 75/502 (14%)
Query: 14 TPQEPSEKAKEQQAEAELRKLRQQFRKMVESRKSFKFRNQQKIASQY-KEIKTLKTEQDE 72
T + E +K E E KL + +S K +NQ + QY KE + L T +E
Sbjct: 591 TCNDSQESSKLSSLETEPVKLGGH-----QVAESVKDQNQHTMNKQYEKERQRLVTGIEE 645
Query: 73 ITLLLSLMKSSR-----NMNRSEKNYMELRLLLQTKEDYEALIKS--------LKVLLAE 119
+ L +++ NM + ++ L K + ++S L L +
Sbjct: 646 LRTKLIQIEAENSDLKVNMAHRTSQFQLIQEELLEKASNSSKLESEMTKKCSQLLTLEKQ 705
Query: 120 LDEKILQMEKKIANQKQIFAKMQEANNPRKLQKQIHILETRLNL----VTVHFDKM---- 171
L+EKI+ A ++ ++ E N ++I LET +N + + F+K
Sbjct: 706 LEEKIVAYSSIAAKNAELEQELMEKN------EKIRSLETNINTEHEKICLAFEKAKKIH 759
Query: 172 LTTNAKLRKEIEDLRFEKAAYDNVYQQLQHCLLMEKKTMNLAIEQSSQAYEQRVEAMARM 231
L + ++ K+IE L + D +++ ++KTM++ ++Q + +E++ R+
Sbjct: 760 LEQHKEMEKQIERLEAQLEKKDQQFKE-------QEKTMSM-LQQDIICKQHHLESLDRL 811
Query: 232 AA-MKDRQKKDTSQYNLEIRELERLYAHESKLKSFLLVKLNDRNEFEEQAKREEAL---- 286
K KK+ + + ++ L+ + E+ +K+ + E K E L
Sbjct: 812 LTESKGEMKKENMKKDEALKALQNQVSEET-------IKVRQLDSALEICKEELVLHLNQ 864
Query: 287 ------KAKKHVKKNRGESFESYEVAHLRLLKLAESGNLNQLIEDFLAKEEKNFARFTYV 340
K +K +KK E + + ++ L E+ N +++ L ++++ + T
Sbjct: 865 LEGNKEKFEKQLKKKSEEVYCLQKELKIKNHSLQETSEQNVILQHTLQQQQQMLQQETIR 924
Query: 341 T-ELNNDMEMMHKRTQRIQDEIILLRSQQKLSHDDNHSVLRQLEDKLRKTTEEADMYESK 399
EL + + K+ +++ E L+ Q++ S + LR++E+K EAD+ K
Sbjct: 925 NGELEDTQTKLEKQVSKLEQE---LQKQRESSAEK----LRKMEEKCESAAHEADLKRQK 977
Query: 400 YGEVSKTLDLLKNSVEKLFKKINCDATKILVQLGETGKVTDINLPQYFAI-------IEK 452
E++ T +K +++ +K+ K ++ L G+ ++L Q I +EK
Sbjct: 978 VIELTGTARQVKIEMDQ-YKEELSKMEKEIMHLKRDGENKAMHLSQLDMILDQTKTELEK 1036
Query: 453 KTNDLLLLETYRRILEVEGAEA 474
KTN + LE + E E EA
Sbjct: 1037 KTNAVKELEKLQHSTETELTEA 1058
Score = 46.6 bits (109), Expect = 6e-05
Identities = 84/414 (20%), Positives = 173/414 (41%), Gaps = 42/414 (10%)
Query: 4 LKKNRRKDSDTPQEPSEKAKEQQAEAELRKLRQQFRKMVESRKSFKFR---NQQKIASQY 60
++ +D+ T E EQ+ + + ++ RKM E +S +QK+
Sbjct: 923 IRNGELEDTQTKLEKQVSKLEQELQKQRESSAEKLRKMEEKCESAAHEADLKRQKVIELT 982
Query: 61 KEIKTLKTEQDEITLLLSLMKSSRNMNRSEKNYMELRLLLQTKEDYEALIKSLKVLLAEL 120
+ +K E D+ +++ EK M L K D E L L L
Sbjct: 983 GTARQVKIEMDQY---------KEELSKMEKEIMHL------KRDGENKAMHLSQLDMIL 1027
Query: 121 DEKILQMEKKIANQKQIFAKMQ---EANNPRKLQKQIHILETRLNLVTVHFDKMLTTNAK 177
D+ ++EKK K++ K+Q E LQK+ +LET L H ++ +T +
Sbjct: 1028 DQTKTELEKKTNAVKEL-EKLQHSTETELTEALQKR-EVLETELQ--NAH-GELKSTLRQ 1082
Query: 178 LRKEIEDLRFEKAAYDNVYQQLQHCLLMEKKTMNLAIEQSSQAYEQRVEAMARMAAMKDR 237
L++ + L+ + + + Y ++ L E + + IE Q + +A+ +
Sbjct: 1083 LQELRDVLQKAQLSLEEKYTTIKD-LTAELRECKMEIEDKKQELLEMDQALKERNWELKQ 1141
Query: 238 QKKDTSQYNLEIRELERLYAHESKLKSFLLVKLNDRNEFE--EQAKREEALKAKKHVKKN 295
+ + ++ IRE + E + K L +++E E E K+ E+L K K
Sbjct: 1142 RAAQVTHLDMTIRE----HRGEMEQKIIKLEGTLEKSELELKECNKQIESLNDKLQNAKE 1197
Query: 296 --RGESF----ESYEVAHLRLLKLAESGNLNQLIEDFLAKEEKNFA-RFTYVTELNNDME 348
R + F E++ L+ ++ + + +E + ++E+ A ++ +L ++
Sbjct: 1198 QLREKEFIMLQNEQEISQLK-KEIERTQQRMKEMESVMKEQEQYIATQYKEAIDLGQELR 1256
Query: 349 MMHKRTQRIQDEIILLRSQQKLSHDDNHSVLRQLEDKLRKTTEEADMYESKYGE 402
+ ++ Q E+ R QQ + + + +LED +++ ++E D + + E
Sbjct: 1257 LTREQVQNSHTELAEARHQQVQAQREIERLSSELED-MKQLSKEKDAHGNHLAE 1309
Score = 35.0 bits (79), Expect = 0.18
Identities = 63/312 (20%), Positives = 125/312 (40%), Gaps = 51/312 (16%)
Query: 22 AKEQQAEAELRKLRQQFRKMVESRKSFKFRNQQKIASQYKEIKTLKTEQDEITLLLSLMK 81
A+ ++ + E+ +Q+ +M ++ K + +Q+ A T++ + E+ + ++
Sbjct: 1109 AELRECKMEIEDKKQELLEMDQALKERNWELKQRAAQVTHLDMTIREHRGEMEQKIIKLE 1168
Query: 82 SSRNMNRSEKNYMELRLLLQTKEDYEALIKSLKVLLAELDEKILQMEKKIANQKQIF--- 138
+ EK+ +EL+ + E +++ K L E + +LQ E++I+ K+
Sbjct: 1169 GTL-----EKSELELKECNKQIESLNDKLQNAKEQLREKEFIMLQNEQEISQLKKEIERT 1223
Query: 139 -AKMQEANNPRKLQKQI-------------HILETRLNLVTVHFDKMLTTN--------- 175
+M+E + K Q+Q + TR + H + +
Sbjct: 1224 QQRMKEMESVMKEQEQYIATQYKEAIDLGQELRLTREQVQNSHTELAEARHQQVQAQREI 1283
Query: 176 AKLRKEIEDLR---FEKAAYDNVYQQ-----------LQHCLLMEKKTMNLAIEQSSQAY 221
+L E+ED++ EK A+ N + L+ + E K ++ +E +AY
Sbjct: 1284 ERLSSELEDMKQLSKEKDAHGNHLAEELGASKVREAHLEARMQAEIKKLSAEVESLKEAY 1343
Query: 222 EQRV----EAMARMAAMKDRQKKDTSQYNLEIRELERLYAHESKLKSFLLVKLNDRNEFE 277
+ E A+ D QK Q N ++ + + S L ++ DRNE
Sbjct: 1344 HMEMISHQENHAKWKISADSQKSSVQQLNEQLEKAKLELEEAQDTVSNLHQQVQDRNEVI 1403
Query: 278 EQAKREEALKAK 289
E A EAL K
Sbjct: 1404 EAA--NEALLTK 1413
>gi|156104908 myosin heavy chain 6 [Homo sapiens]
Length = 1939
Score = 68.2 bits (165), Expect = 2e-11
Identities = 108/492 (21%), Positives = 217/492 (44%), Gaps = 98/492 (19%)
Query: 26 QAEAELRKLRQQFRKMVESRKS-----------------------FKFRNQQKIASQYKE 62
QA+A + +R +F+K+VE R + FK + K A KE
Sbjct: 791 QAQARGQLMRIEFKKIVERRDALLVIQWNIRAFMGVKNWPWMKLYFKIKPLLKSAETEKE 850
Query: 63 IKTLKTEQDEITLLLSLMKSSRNMNRSEKNYMELRLLLQTKEDYEALIKSLKVLLAELDE 122
+ T+K E I +L KS E+ + LLQ K D + +++ + L + +E
Sbjct: 851 MATMKEEFGRIK--ETLEKSEARRKELEEKMVS---LLQEKNDLQLQVQAEQDNLNDAEE 905
Query: 123 KILQMEKKIANQKQIFAKMQEANNPRKLQKQIHI--------LETRLNLVTVHFDKMLTT 174
+ Q+ I N+ Q+ AK++E N + +++++ LE + + D + T
Sbjct: 906 RCDQL---IKNKIQLEAKVKEMNERLEDEEEMNAELTAKKRKLEDECSELKKDIDDLELT 962
Query: 175 NAKLRKE-------IEDLRFEKAAYDNVYQQLQHCLLMEKKTMNLAIEQS---SQAYEQR 224
AK+ KE +++L E A D + + L EKK + A +Q+ Q E +
Sbjct: 963 LAKVEKEKHATENKVKNLTEEMAGLDEIIAK----LTKEKKALQEAHQQALDDLQVEEDK 1018
Query: 225 VEAMARMAAMKDRQKKDTSQYNLEIRELERLYAHESKLKSFLLVKL---------NDRNE 275
V ++++ + +K Q+ D + +LE + R+ +K K +KL ND+ +
Sbjct: 1019 VNSLSK-SKVKLEQQVDDLEGSLEQEKKVRMDLERAKRKLEGDLKLTQESIMDLENDKLQ 1077
Query: 276 FEEQAKREE----------------ALKAKKHVKKNRG------ESFESYEVAHLRLLKL 313
EE+ K++E AL+ +K +K+N+ E E+ A ++ KL
Sbjct: 1078 LEEKLKKKEFDINQQNSKIEDEQVLALQLQKKLKENQARIEELEEELEAERTARAKVEKL 1137
Query: 314 AESGNLNQLIEDFLAKEEKNFARFTYVTELNNDMEMMHKRTQRIQDEIIL----LRSQQK 369
+L++ +E+ + E+ + E+N E ++ +R +E L + +
Sbjct: 1138 --RSDLSRELEEISERLEEAGGATSVQIEMNKKREAEFQKMRRDLEEATLQHEATAAALR 1195
Query: 370 LSHDDNHSVLRQLEDKLRKTTEEADMYESKY----GEVSKTLDLL---KNSVEKLFKKIN 422
H D+ + L + D L++ ++ + +S++ +V+ ++ + K ++EK+ + +
Sbjct: 1196 KKHADSVAELGEQIDNLQRVKQKLEKEKSEFKLELDDVTSNMEQIIKAKANLEKVSRTLE 1255
Query: 423 CDATKILVQLGE 434
A + V+L E
Sbjct: 1256 DQANEYRVKLEE 1267
Score = 53.1 bits (126), Expect = 7e-07
Identities = 90/446 (20%), Positives = 184/446 (41%), Gaps = 62/446 (13%)
Query: 9 RKDSDTPQEPSEKAKEQQAEA-----ELRKLRQQFRKMVESRKSFKFRNQQKIASQYKEI 63
++++ QE EQ E EL K+R+Q VE + + + + +++E
Sbjct: 1501 KRENKNLQEEISDLTEQLGEGGKNVHELEKVRKQLE--VEKLELQSALEEAEASLEHEEG 1558
Query: 64 KTLKTE----QDEITLLLSLMKSSRNMNRSEKNYMELRLLLQTKEDYEALIKSLKVLLAE 119
K L+ + Q + + L + M ++++N+ + LQT D E ++
Sbjct: 1559 KILRAQLEFNQIKAEIERKLAEKDEEMEQAKRNHQRVVDSLQTSLDAETRSRN------- 1611
Query: 120 LDEKILQMEKKIANQ-KQIFAKMQEANN-PRKLQKQIHILETRLNLVTVHFDKMLTTNAK 177
++L+++KK+ ++ ++ AN + QKQ+ L++ L + D + N
Sbjct: 1612 ---EVLRVKKKMEGDLNEMEIQLSHANRMAAEAQKQVKSLQSLLKDTQIQLDDAVRANDD 1668
Query: 178 LRKEIEDLRFEKAAYDNVYQQLQHCLLMEKKTMNLAIEQSSQAYEQRVEAM----ARMAA 233
L++ I + ++L+ + +++ LA EQ +RV+ + +
Sbjct: 1669 LKENIAIVERRNNLLQAELEELRAVVEQTERSRKLA-EQELIETSERVQLLHSQNTSLIN 1727
Query: 234 MKDRQKKDTSQYNLEIRE-LERLYAHESKLKSFLLVKLNDRNEFEEQAKREEALKAK-KH 291
K + + D +Q E+ E ++ E K K + D E+ K+E+ A +
Sbjct: 1728 QKKKMESDLTQLQSEVEEAVQECRNAEEKAKK----AITDAAMMAEELKKEQDTSAHLER 1783
Query: 292 VKKNRGESFESYEVAHLRLLKLAESGNLNQL---------IEDFLAKEEKNFARFT---- 338
+KKN ++ + + ++A G QL +E L E+K A
Sbjct: 1784 MKKNMEQTIKDLQHRLDEAEQIALKGGKKQLQKLEARVRELEGELEAEQKRNAESVKGMR 1843
Query: 339 ----YVTELNNDMEMMHKRTQRIQDEIILLRSQQKL----------SHDDNHSVLRQLED 384
+ EL E K R+QD + L+ + K + N S R+++
Sbjct: 1844 KSERRIKELTYQTEEDKKNLLRLQDLVDKLQLKVKAYKRQAEEAEEQANTNLSKFRKVQH 1903
Query: 385 KLRKTTEEADMYESKYGEV-SKTLDL 409
+L + E AD+ ES+ ++ +K+ D+
Sbjct: 1904 ELDEAEERADIAESQVNKLRAKSRDI 1929
Score = 43.9 bits (102), Expect = 4e-04
Identities = 92/468 (19%), Positives = 186/468 (39%), Gaps = 67/468 (14%)
Query: 19 SEKAKEQQAEAELRKLRQQFRKMVESRKSFKFRNQQKIASQYKEIKTLKTEQDEITLLLS 78
+++AK Q EL + ++ ++ K Q++ ++ L+ E L
Sbjct: 1277 TQRAKLQTENGELARQLEEKEALISQLTRGKLSYTQQMEDLKRQ---LEEEGKAKNALAH 1333
Query: 79 LMKSSRNMNRSEKNYMELRLLLQTKEDYEALIKSLKVLLAELDEKILQMEKKIANQK-QI 137
++S+R+ + LL + E+ L+ +L++ + ++ Q K Q
Sbjct: 1334 ALQSARH---------DCDLLREQYEEETEAKAELQRVLSKANSEVAQWRTKYETDAIQR 1384
Query: 138 FAKMQEANNPRKLQKQIHILETRLNLVTVHFDKMLTTNAKLRKEIEDLRFEKAAYDNVYQ 197
+++EA +KL +++ E + V + T +L+ EIEDL + V +
Sbjct: 1385 TEELEEAK--KKLAQRLQDAEEAVEAVNAKCSSLEKTKHRLQNEIEDLMVD------VER 1436
Query: 198 QLQHCLLMEKKTMNL--AIEQSSQAYEQRVEAMARMAAMKDRQKKDTSQYNLEIRELERL 255
++KK N + + Q YE+ + + +K+ + E+ +L+
Sbjct: 1437 SNAAAAALDKKQRNFDKILAEWKQKYEESQSEL-------ESSQKEARSLSTELFKLKN- 1488
Query: 256 YAHESKLKSFLLVKLNDRNEFEEQAKREEAL-----------KAKKHVKKNRGESFESYE 304
A+E L+ K ++N EE + E L K +K ++ + E + E
Sbjct: 1489 -AYEESLEHLETFKRENKNLQEEISDLTEQLGEGGKNVHELEKVRKQLEVEKLELQSALE 1547
Query: 305 VAHLRLLKLAESGNLNQLIEDF---LAKEEKNFARFTYVTELNNDMEMMHKRTQRIQDEI 361
A L E G + + +F A+ E+ A E + +ME + QR+ D +
Sbjct: 1548 EAEASLEH--EEGKILRAQLEFNQIKAEIERKLA------EKDEEMEQAKRNHQRVVDSL 1599
Query: 362 ILLRSQQKLSHDDNHSVLRQLEDKLRKTTEEADMYESKYGEVSKTLDLLKNSVEKLFKKI 421
+ S ++ V +++E L + + E K + S++ L K
Sbjct: 1600 QTSLDAETRSRNEVLRVKKKMEGDLNEMEIQLSHANRMAAEAQKQV----KSLQSLLKDT 1655
Query: 422 NCDATKILVQLGETGKVTDINLPQYFAIIEKKTNDLLL-LETYRRILE 468
+QL + + D +L + AI+E++ N L LE R ++E
Sbjct: 1656 Q-------IQLDDAVRAND-DLKENIAIVERRNNLLQAELEELRAVVE 1695
Score = 43.5 bits (101), Expect = 5e-04
Identities = 83/429 (19%), Positives = 181/429 (42%), Gaps = 56/429 (13%)
Query: 23 KEQQAEAELRKLRQQFRKMVESRKSFKFRNQQKIAS-QYKEIKTLKTEQDEITLLLSLMK 81
K + E+ L + K+ + +K+ + +QQ + Q +E K + ++ L +
Sbjct: 976 KVKNLTEEMAGLDEIIAKLTKEKKALQEAHQQALDDLQVEEDKVNSLSKSKVKLEQQVDD 1035
Query: 82 SSRNMNRSEKNYMELRLLLQTKEDYEALIKSLKVLLAELDEKILQMEKKIANQK----QI 137
++ + +K M+L + K E +K + + +L+ LQ+E+K+ ++ Q
Sbjct: 1036 LEGSLEQEKKVRMDLE---RAKRKLEGDLKLTQESIMDLENDKLQLEEKLKKKEFDINQQ 1092
Query: 138 FAKMQEANN-PRKLQKQIHILETRLNLVTVHFDKMLTTNAKLRKEIEDLRFEKAAYDNVY 196
+K+++ +LQK++ + R+ + + T AK+ K DL E + +
Sbjct: 1093 NSKIEDEQVLALQLQKKLKENQARIEELEEELEAERTARAKVEKLRSDLSRE---LEEIS 1149
Query: 197 QQLQHC-------LLMEKKTMNLAIEQSSQAYEQRVEAMARMAAMKDRQKKDTSQYNLEI 249
++L+ + M KK + E ++ A AA++ + ++ +I
Sbjct: 1150 ERLEEAGGATSVQIEMNKKREAEFQKMRRDLEEATLQHEATAAALRKKHADSVAELGEQI 1209
Query: 250 RELERLYAHESKLKSFLLVKLNDRNEFEEQAKREEALKAKKHVKKNRGESFESYEVAHLR 309
L+R+ K KS ++L+D + E+ +KAK +++K S + A+
Sbjct: 1210 DNLQRVKQKLEKEKSEFKLELDD-----VTSNMEQIIKAKANLEK---VSRTLEDQANEY 1261
Query: 310 LLKLAESGNLNQLIEDFLAKEEKNFARFTYVTELNNDMEMMHKRTQRIQDEIILLRSQQK 369
+KL E+ + + DF + K T EL +E ++ +I ++ K
Sbjct: 1262 RVKLEEA---QRSLNDFTTQRAK---LQTENGELARQLEE--------KEALISQLTRGK 1307
Query: 370 LSHDDN-HSVLRQLEDK----------LRKTTEEADMYESKYGEVSKTLDLLKNSVEKLF 418
LS+ + RQLE++ L+ + D+ +Y E ++ K ++++
Sbjct: 1308 LSYTQQMEDLKRQLEEEGKAKNALAHALQSARHDCDLLREQYEEETEA----KAELQRVL 1363
Query: 419 KKINCDATK 427
K N + +
Sbjct: 1364 SKANSEVAQ 1372
>gi|38045898 RAB6-interacting protein 2 isoform epsilon [Homo
sapiens]
Length = 1116
Score = 66.6 bits (161), Expect = 6e-11
Identities = 97/494 (19%), Positives = 225/494 (45%), Gaps = 57/494 (11%)
Query: 4 LKKNRRKDSDTPQEPSEKAKEQQAEAELRKLRQQFRKMVESRKSFKFRNQQKIASQYKEI 63
L + + K++ +E + E ++ K Q +M +S+ S R + + + + +
Sbjct: 349 LLEQKEKENSMLREEMHRRFENAPDSAKTKALQTVIEMKDSKISSMERGLRDLEEEIQML 408
Query: 64 KT---LKTEQDEITLLLSLMKSSRNMNRSEKNYME-LRLLLQTKE-DYEALIKSLKVLLA 118
K+ L TE+ E + M+ R+ ++ KN +E L+ L +KE +E L K L A
Sbjct: 409 KSNGALSTEEREEEM--KQMEVYRSHSKFMKNKVEQLKEELSSKEAQWEELKKKAAGLQA 466
Query: 119 EL----------DEKILQMEKKI-------ANQKQIFAKMQEANNPRKLQKQIHILETRL 161
E+ D ++L ++ K+ ++ KQ ++E+ + +++ IL+T +
Sbjct: 467 EIGQVKQELSRKDTELLALQTKLETLTNQFSDSKQHIEVLKESLTAK--EQRAAILQTEV 524
Query: 162 NLVTVHFDKMLTTNAKLRKEIEDLRFEKAAYDNVYQQLQHCLLMEKKTMNLAIEQSSQAY 221
+ + + ++ T K K+I+D+ EK L+ L ++++ +N+ ++
Sbjct: 525 DALRLRLEEKETMLNKKTKQIQDMAEEKGTQAGEIHDLKDMLDVKERKVNVLQKKIENLQ 584
Query: 222 EQRVEAMARMAAMKDRQKK---DTSQYNLEIRELERLYAHESKLKSFLLVKLNDRNEFEE 278
EQ + +M+++K+R K DT+ + + LE A + + + +L ++ + +E
Sbjct: 585 EQLRDKEKQMSSLKERVKSLQADTTNTDTALTTLEEALAEKER----TIERLKEQRDRDE 640
Query: 279 QAKREEALKAKKHVKKNRGESFESYEVAHLRLLKLAESGNLNQLIEDFLAKEEKNFARFT 338
+ K+EE KK +K + + + LL+ G+L++ L +E + +
Sbjct: 641 REKQEEIDNYKKDLKDLKEK---------VSLLQ----GDLSEKEASLLDLKEHASSLAS 687
Query: 339 YVTELNNDMEMMHKRTQRIQDEIILLRSQQKLSHDD--NHSVLRQLEDKLRKTTEEADMY 396
+ ++ ++ + ++ ++E + + SQ K +H+ ++ D+++ E Y
Sbjct: 688 SGLKKDSRLKTLEIALEQKKEECLKMESQLKKAHEAALEARASPEMSDRIQHLEREITRY 747
Query: 397 ESKYGEVSKTLDLLKNSVEKLFKKINCDATKILVQL-----GETGKVTDINLPQYFAIIE 451
+ + + +D L ++++ + N D K + +L + KV ++ + +E
Sbjct: 748 KDESSKAQAEVDRLLEILKEVENEKN-DKDKKIAELERQVKDQNKKVANLKHKEQ---VE 803
Query: 452 KKTNDLLLLETYRR 465
KK + +L E RR
Sbjct: 804 KKKSAQMLEEARRR 817
Score = 49.3 bits (116), Expect = 9e-06
Identities = 68/326 (20%), Positives = 140/326 (42%), Gaps = 56/326 (17%)
Query: 150 LQKQIHILETRL----NLVTVHFDKMLTTNAKLRK-EIEDLRFEKAAYDNVYQQLQHCLL 204
L+K + + E++L N + + L LRK E + K Y V ++ QH
Sbjct: 168 LRKDVEVKESKLSSSMNSIKTFWSPELKKERALRKDEASKITIWKEQYRVVQEENQH--- 224
Query: 205 MEKKTMNLAIEQSSQAYEQRVEAMARMAAMKDRQKKDTSQYNLEIRE--LERLYA-HESK 261
M + I+ E R++ +D + E+ E +RL+A HE +
Sbjct: 225 -----MQMTIQALQD--ELRIQRDLNQLFQQDSSSRTGEPCVAELTEENFQRLHAEHERQ 277
Query: 262 LKSFLLVK-----LNDRNEFEEQA--KREEALKAKKHVKKNRGESFESYEVAHLRLLKLA 314
K L++ + R E ++Q R+E++K + +++G S ++ E H R +LA
Sbjct: 278 AKELFLLRKTLEEMELRIETQKQTLNARDESIKKLLEMLQSKGLSAKATEEDHERTRRLA 337
Query: 315 ESGNLNQLIEDFLAKEEKN--------FARF-------------TYVTELNNDMEMMHKR 353
E+ +E L ++EK RF T + ++ + M +
Sbjct: 338 EAEMHVHHLESLLEQKEKENSMLREEMHRRFENAPDSAKTKALQTVIEMKDSKISSMERG 397
Query: 354 TQRIQDEIILLRSQQKLSHDDNHSVLRQLE----------DKLRKTTEEADMYESKYGEV 403
+ +++EI +L+S LS ++ ++Q+E +K+ + EE E+++ E+
Sbjct: 398 LRDLEEEIQMLKSNGALSTEEREEEMKQMEVYRSHSKFMKNKVEQLKEELSSKEAQWEEL 457
Query: 404 SKTLDLLKNSVEKLFKKINCDATKIL 429
K L+ + ++ ++++ T++L
Sbjct: 458 KKKAAGLQAEIGQVKQELSRKDTELL 483
Score = 46.2 bits (108), Expect = 8e-05
Identities = 82/402 (20%), Positives = 176/402 (43%), Gaps = 48/402 (11%)
Query: 1 MSVLKKNRRK-DSDTPQEPSEKAKEQQAEAELRKLRQQFRKMVESRKSFKFRNQQKIASQ 59
MS LK+ + +DT + ++A AE + ++ + E R + Q++I +
Sbjct: 594 MSSLKERVKSLQADTTNTDTALTTLEEALAEKERTIERLK---EQRDRDEREKQEEIDNY 650
Query: 60 YKEIKTLKTEQDEITLLLSLMKSSRNMNRSEKNYMELR----LLLQTKEDYEALIKSLKV 115
K++K LK ++++LL +++ E + ++L+ L + ++ +K+L++
Sbjct: 651 KKDLKDLK---EKVSLLQG------DLSEKEASLLDLKEHASSLASSGLKKDSRLKTLEI 701
Query: 116 LLAELDEKILQMEKKIANQKQIFAKMQEANNPRKLQKQIHILETRLNLVTVHFDKMLTTN 175
L + E+ L+ME ++ K+ EA ++ +I LE +T + D+
Sbjct: 702 ALEQKKEECLKMESQL---KKAHEAALEARASPEMSDRIQHLERE---ITRYKDESSKAQ 755
Query: 176 AKLRKEIEDLRFEKAAYDNVYQQLQHCLLMEKKTMNLAIEQSSQAYEQRVEAMARMAAMK 235
A++ + +E L+ ++++ EK + I + + + + + +A + +
Sbjct: 756 AEVDRLLEILK-----------EVEN----EKNDKDKKIAELERQVKDQNKKVANLKHKE 800
Query: 236 DRQKKDTSQYNLEIRELERLYAHESKLKSFLLVKLNDRNEFEEQAKREEA-LKAKKHVKK 294
+KK ++Q E R E S+ L K +DR E E+A RE + A++ +
Sbjct: 801 QVEKKKSAQMLEEARRREDNLNDSSQQLQDSLRKKDDRIEELEEALRESVQITAEREMVL 860
Query: 295 NRGESFESYEVAHLRLLKLAESGNLNQLIEDFLAK----EEKNFARFTYVTELNNDMEMM 350
+ ES + + L +A + Q +E AK ++ + T++T L +
Sbjct: 861 AQEESARTNAEKQVEELLMAME-KVKQELESMKAKLSSTQQSLAEKETHLTNLRAERRKH 919
Query: 351 HKRTQRIQDEIILLRSQQKLSHDDNHSVLRQLEDKLRKTTEE 392
+ ++ E +L +S D + L +L +KT EE
Sbjct: 920 LEEVLEMKQEALL----AAISEKDANIALLELSSSKKKTQEE 957
>gi|6715600 golgi autoantigen, golgin subfamily a, 4 [Homo sapiens]
Length = 2230
Score = 66.2 bits (160), Expect = 7e-11
Identities = 102/457 (22%), Positives = 197/457 (43%), Gaps = 79/457 (17%)
Query: 17 EPSEKAKEQQAEAELRKLR-QQFRKMVESRKSFKFRNQQKIASQYKEIKTLKTEQDEITL 75
E + K+ E + K++ Q + +E + S + + + Y+ ++ E T
Sbjct: 844 EVEAQKKDVCTELDAHKIQVQDLMQQLEKQNSEMEQKVKSLTQVYESKLEDGNKEQEQTK 903
Query: 76 LLSLMKSSRNMNRSEKNYMELRLLLQ---TKEDYEALIKSLKVLLAELDEKILQMEKKIA 132
+ + K + + E E+ +L Q KED S+ +L E + K EKK+
Sbjct: 904 QILVEKENMILQMREGQKKEIEILTQKLSAKED------SIHILNEEYETKFKNQEKKME 957
Query: 133 NQKQIFAKMQEANNPRKLQKQIHILETRLNLVTVHFDKMLTTNAKLRKEIEDLRFEKAAY 192
KQ +MQE L+K K+L AKL+KE+E+ E
Sbjct: 958 KVKQKAKEMQET-----LKK-----------------KLLDQEAKLKKELENTALE---- 991
Query: 193 DNVYQQLQHCLLMEKKTMNLAIEQSSQAYEQRV-EAMARMAAMKDRQKKDTSQYNLEIRE 251
L ++K N + + +QA + +A++R+ + Q + ++ + RE
Sbjct: 992 ----------LSQKEKQFNAKMLEMAQANSAGISDAVSRLETNQKEQIESLTE--VHRRE 1039
Query: 252 LERLYAHESKLKSFLLVKLNDRNEFEEQAKREEALKAKKHVKKNRGESFE-SYEVAHLRL 310
L + + K + +L + +E + Q K +E + K+ + E E + E+ L+
Sbjct: 1040 LNDVISIWEKKLNQQAEELQEIHEIQLQEKEQEVAELKQKILLFGCEKEEMNKEITWLKE 1099
Query: 311 LKLAESGNLNQLIEDF---------LAKEEKNFARFTYVTELNNDMEMMHKRTQRIQDEI 361
+ + LN+L E LA++E ++ +L D+ K +Q+++
Sbjct: 1100 EGVKQDTTLNELQEQLKQKSAHVNSLAQDETKLK--AHLEKLEVDLNKSLKENTFLQEQL 1157
Query: 362 ILLRSQQKLSHDDNHSVLRQLEDKLRKTTEEADMYESKYGEVSKTLDLLKNSVEKLFKKI 421
+ L+ L+ +D V +L KL+ T EE +S + + +K+L+ S+E FKK+
Sbjct: 1158 VELK---MLAEEDKRKV-SELTSKLKTTDEEFQSLKSSHEKSNKSLE--DKSLE--FKKL 1209
Query: 422 NCDATKILVQLGETGKVTDINLPQYFAIIEKKTNDLL 458
+ ++ +QL K T+ A++E KTN+L+
Sbjct: 1210 ---SEELAIQLDICCKKTE-------ALLEAKTNELI 1236
Score = 54.7 bits (130), Expect = 2e-07
Identities = 91/454 (20%), Positives = 192/454 (42%), Gaps = 65/454 (14%)
Query: 5 KKNRRKDSDTPQEPSE-KAKEQQAEAELRKLRQQFRKMVESRKSFKF---RNQQKIASQY 60
+K + T SE K Q+ E E+ L ++ K VES +S R+ + +A+
Sbjct: 1661 EKEEQYKKGTESHLSELNTKLQEREREVHILEEKL-KSVESSQSETLIVPRSAKNVAAYT 1719
Query: 61 KEIKT------LKTEQDEITLLLSLMKSSRNMNRSEKNYMELRLLLQTKEDYEALIKSLK 114
++ + KT +++I++L RN+ EK LL + ++ E + S
Sbjct: 1720 EQEEADSQGCVQKTYEEKISVL------QRNLTEKEK------LLQRVGQEKEETVSSHF 1767
Query: 115 VLLAELDEKILQMEKKIANQKQ-------IFAKMQEANNPRKLQKQIHI--------LET 159
+ + E+++++E A Q + + +++E N L H+ ++
Sbjct: 1768 EMRCQYQERLIKLEHAEAKQHEDQSMIGHLQEELEEKNKKYSLIVAQHVEKEGGKNNIQA 1827
Query: 160 RLNLVTVHFDKMLTTNAKLRKEIEDLRFEKAAYDNVYQQLQHCLLMEKKTMNLAIEQSSQ 219
+ NL V D ++K +++ + ++L CL+ +K+ + +E+ +
Sbjct: 1828 KQNLENVFDD--------VQKTLQEKELTCQILEQKIKELDSCLVRQKEVHRVEMEELTS 1879
Query: 220 AYEQRVEAMARMAAMKDRQKKDTSQYNLEIRELERLYAHESKLKSFLLVKLNDRN----- 274
YE +++A+ +M D + K T E + + + KL S + + ND
Sbjct: 1880 KYE-KLQALQQM----DGRNKPTELLEENTEEKSKSHLVQPKLLSNMEAQHNDLEFKLAG 1934
Query: 275 -EFEEQAKREEALKAKKHVKKNRGESFESYEVAHLRLLKLAESGNLNQLIEDFLAKEEKN 333
E E+Q +E ++ +K ++ R E + E+ + E + Q ED K
Sbjct: 1935 AEREKQKLGKEIVRLQKDLRMLRKEHQQELEILKKEYDQEREE-KIKQEQEDLELKHNST 1993
Query: 334 FARF-----TYVTELNNDMEMMHKRT-QRIQD-EIILLRSQQKLSHDDNHSVLRQLEDKL 386
+ T + + ++EM K T + Q+ E LL S Q+ ++ + + +D
Sbjct: 1994 LKQLMREFNTQLAQKEQELEMTIKETINKAQEVEAELLESHQEETNQLLKKIAEKDDDLK 2053
Query: 387 RKTTEEADMYESKYGEVSKTLDLLKNSVEKLFKK 420
R ++ +++ E++ + L+ +E+L KK
Sbjct: 2054 RTAKRYEEILDAREEEMTAKVRDLQTQLEELQKK 2087
Score = 50.1 bits (118), Expect = 6e-06
Identities = 91/442 (20%), Positives = 180/442 (40%), Gaps = 66/442 (14%)
Query: 17 EPSEKAKEQQAEAELRKLRQQFRKMVESRKSFKFRNQQKIASQYKEIKTLKTEQDEITLL 76
E K +EQ + + K +M E +K QK++++ I L E +
Sbjct: 893 EDGNKEQEQTKQILVEK-ENMILQMREGQKKEIEILTQKLSAKEDSIHILNEEYET---- 947
Query: 77 LSLMKSSRNMNRSEKNYMELRLLLQTKE-DYEA-LIKSLKVLLAELDEKILQMEKKIANQ 134
+ M + ++ E++ L+ K D EA L K L+ EL +K Q K+
Sbjct: 948 -KFKNQEKKMEKVKQKAKEMQETLKKKLLDQEAKLKKELENTALELSQKEKQFNAKMLEM 1006
Query: 135 KQIFA-------KMQEANNPRKLQKQIHILETRLNLVTVHFDKMLTTNAKLRKEIEDLRF 187
Q + E N +++ + LN V ++K L A+ +EI +++
Sbjct: 1007 AQANSAGISDAVSRLETNQKEQIESLTEVHRRELNDVISIWEKKLNQQAEELQEIHEIQL 1066
Query: 188 EKAAYDNVYQQLQHCLLM--EKKTMNLAIEQSSQAYEQRVEAMARMAAMKDRQKKDTSQY 245
++ + V + Q LL EK+ MN I + E+ V+ + ++++ K+ ++
Sbjct: 1067 QEKEQE-VAELKQKILLFGCEKEEMNKEI---TWLKEEGVKQDTTLNELQEQLKQKSAHV 1122
Query: 246 NLEIRELERLYAHESKLKSFLLVKLNDRNEFEEQAKREEALKAKKHVK--------KNRG 297
N ++ +L AH KL+ L L + +EQ + L + K K
Sbjct: 1123 NSLAQDETKLKAHLEKLEVDLNKSLKENTFLQEQLVELKMLAEEDKRKVSELTSKLKTTD 1182
Query: 298 ESFESYEVAHLRLLKLAESGNLNQLIEDFLAKEEKNFARFTYVTELNNDMEMMHKRTQRI 357
E F+S + +H + K E +L E K + EL +++ K+T+ +
Sbjct: 1183 EEFQSLKSSHEKSNKSLEDKSL----------EFKKLSE-----ELAIQLDICCKKTEAL 1227
Query: 358 QD----EIILLRSQQ------KLSHDDNHSV------------LRQLEDKLRKTTEEADM 395
+ E+I + S + ++SH + + + +LE +LR+ TEE +
Sbjct: 1228 LEAKTNELINISSSKTNAILSRISHCQHRTTKVKEALLIKTCTVSELEAQLRQLTEEQNT 1287
Query: 396 YESKYGEVSKTLDLLKNSVEKL 417
+ + + L+ +N ++ +
Sbjct: 1288 LNISFQQATHQLEEKENQIKSM 1309
Score = 47.4 bits (111), Expect = 4e-05
Identities = 64/350 (18%), Positives = 143/350 (40%), Gaps = 54/350 (15%)
Query: 63 IKTLKTEQDEITLLLSLMKSSRNMNRSEKNYMELRLLLQTKEDYEALIKSLKVLLAELDE 122
+KTL+T Q + +L+K + +S K + LL KE L +LDE
Sbjct: 278 VKTLETLQQRVKRQENLLKRCKETIQSHKE--QCTLLTSEKE----------ALQEQLDE 325
Query: 123 KILQMEK----KIANQKQIFAKMQEANNPRKLQKQIHILETRLNLVTVHFDKMLTTNAKL 178
++ ++EK +A + ++ ++++A N + +Q DK +
Sbjct: 326 RLQELEKIKDLHMAEKTKLITQLRDAKNLIEQLEQ---------------DKGMVIAETK 370
Query: 179 RKEIEDLRFEKAAYDNVYQQLQHCLLMEKKTMNLAIEQSSQAYEQRVEAMARMAAMKDRQ 238
R+ E L ++ + +++ ++ + A+E+ +A++ ++ +
Sbjct: 371 RQMHETLEMKEEEIAQLRSRIKQMTTQGEELREQKEKSERAAFEELEKALSTAQKTEEAR 430
Query: 239 KKDTSQYNLEIRELERLYAHESKLKSFLLVKLNDRNEFEEQAKREEALKAKKHVKKNRGE 298
+K ++ + +I+ +E+ +E E + ++E + K+ V +
Sbjct: 431 RKLKAEMDEQIKTIEKT------------------SEEERISLQQELSRVKQEVVDVMKK 472
Query: 299 SFESYEVAHLRLLKLAESGNLNQLIEDFLAKEEKNFARFTYVTELNNDMEMMHKRTQRIQ 358
S E ++A L+ L E Q + L E+ F V + E + ++ Q
Sbjct: 473 SSEE-QIAKLQKLHEKELARKEQELTKKLQTREREFQEQMKVALEKSQSEYLKISQEKEQ 531
Query: 359 DEIILLRSQQKLSHDDNHSVLRQLEDKLRKTTEEADMYESKYGEVSKTLD 408
E + L + ++L + E+KLR +EA+ Y ++ E+ +L+
Sbjct: 532 QESLALEELEL----QKKAILTESENKLRDLQQEAETYRTRILELESSLE 577
Score = 44.7 bits (104), Expect = 2e-04
Identities = 62/290 (21%), Positives = 125/290 (43%), Gaps = 41/290 (14%)
Query: 8 RRKDSDTPQEPSE-KAKEQQAEAELRKLRQQFRKMVESRKSFKFRNQQKIASQYKEI-KT 65
R K ++ +E +E K+K + +L + +E + + R +QK+ + + K
Sbjct: 1893 RNKPTELLEENTEEKSKSHLVQPKLLSNMEAQHNDLEFKLAGAEREKQKLGKEIVRLQKD 1952
Query: 66 LKTEQDEITLLLSLMKSSRNMNRSEKNYMELRLLLQTKEDYEALIKS-LKVLLAELDEKI 124
L+ + E L ++K + R EK + Q +ED E S LK L+ E + ++
Sbjct: 1953 LRMLRKEHQQELEILKKEYDQEREEK-------IKQEQEDLELKHNSTLKQLMREFNTQL 2005
Query: 125 LQMEKKIANQ-KQIFAKMQEANNPRKLQKQIHILETRLNLVTVHFDKMLTTNAKLRKEIE 183
Q E+++ K+ K QE + +LE+ H ++ K+ ++ +
Sbjct: 2006 AQKEQELEMTIKETINKAQEV--------EAELLES-------HQEETNQLLKKIAEKDD 2050
Query: 184 DLRFEKAAYDNVYQQLQHCLLMEKKTMNLAIEQSSQAYEQRVEAMARMAAMKDRQKKDTS 243
DL+ Y+ + + + + + + +E+ + Y+Q++E Q+++
Sbjct: 2051 DLKRTAKRYEEILDAREEEMTAKVRDLQTQLEELQKKYQQKLE-----------QEENPG 2099
Query: 244 QYNLEIRELERLYAHESKLKSFLLVKLNDRNEFEEQAKREEALKAKKHVK 293
N+ I EL+ A ++ L S +K EF EQ E + KK+ K
Sbjct: 2100 NDNVTIMELQTQLAQKTTLISDSKLK---EQEFREQIHNLED-RLKKYEK 2145
Score = 44.3 bits (103), Expect = 3e-04
Identities = 67/304 (22%), Positives = 131/304 (43%), Gaps = 54/304 (17%)
Query: 21 KAKEQQAEAELRKLRQQ---FRKMVESRKSFKFRNQQKIASQYKEIKTLKTEQDEITLLL 77
K QQ + E ++L Q+ F+++ E + + ++KI + ++ ++K E L
Sbjct: 1549 KNYNQQKDIEHKELVQKLQHFQELGEEKDNRVKEAEEKILTLENQVYSMKAE------LE 1602
Query: 78 SLMKSSRNMNRSEKNYMELRLLLQTKEDYEALIKSLKVLLAELDEKILQMEKKIANQKQI 137
+ K ++N S K+ E L+ + + E+ K LAEL K Q K A +KQ+
Sbjct: 1603 TKKKELEHVNLSVKSKEEELKALEDRLESESAAK-----LAELKRKAEQ--KIAAIKKQL 1655
Query: 138 FAKMQEANNPRKLQKQIHILETRLNLVTVHFDKMLTTNAKLRKEIEDLRFEKAAYDNVYQ 197
++M+E K + H+ E N KL++ ++ + +V
Sbjct: 1656 LSQMEEKEEQYKKGTESHLSE---------------LNTKLQEREREVHILEEKLKSVES 1700
Query: 198 QLQHCLLMEKKTMNLAI-----EQSSQ-----AYEQRVEAMARMAAMKDR-------QKK 240
L++ + N+A E SQ YE+++ + R K++ +K+
Sbjct: 1701 SQSETLIVPRSAKNVAAYTEQEEADSQGCVQKTYEEKISVLQRNLTEKEKLLQRVGQEKE 1760
Query: 241 DTSQYNLEIR-----ELERLYAHESKLKSFLLVKLNDRNEFEEQAKREEALKAKKHVKKN 295
+T + E+R L +L E+K + + + E EE+ K+ + A +HV+K
Sbjct: 1761 ETVSSHFEMRCQYQERLIKLEHAEAKQHEDQSMIGHLQEELEEKNKKYSLIVA-QHVEKE 1819
Query: 296 RGES 299
G++
Sbjct: 1820 GGKN 1823
Score = 38.5 bits (88), Expect = 0.017
Identities = 77/363 (21%), Positives = 151/363 (41%), Gaps = 55/363 (15%)
Query: 88 RSEKNYMELRLLLQTKEDYEALIKSLKVLLAELDEKILQMEKKIANQKQIFAKMQEANNP 147
+S++ Y + + KE+ + K L E+++ +MEKK +N + ++
Sbjct: 1470 KSKEAYEKDEQINLLKEELDQQNKRFDCLKGEMEDDKSKMEKKESNLETEL----KSQTA 1525
Query: 148 RKLQKQIHILETRLNLVTVHFDKMLTTNAKLRKEIEDLRFEKAAYDNVYQQLQHC--LLM 205
R ++ + HI + + + +++ + N +K+IE + + Q+LQH L
Sbjct: 1526 RIMELEDHITQKTIEIESLN---EVLKNYNQQKDIE--------HKELVQKLQHFQELGE 1574
Query: 206 EKKTMNLAIEQSSQAYEQRVEAMARMAAMKDRQKKDTSQYNLEIR-ELERLYAHESKLKS 264
EK E+ E +V + M A + +KK+ NL ++ + E L A E +L+S
Sbjct: 1575 EKDNRVKEAEEKILTLENQVYS---MKAELETKKKELEHVNLSVKSKEEELKALEDRLES 1631
Query: 265 FLLVKLNDRNEFEEQ-------------AKREEALK--AKKHVKKNRGESFESYEVAHL- 308
KL + EQ ++EE K + H+ + + E H+
Sbjct: 1632 ESAAKLAELKRKAEQKIAAIKKQLLSQMEEKEEQYKKGTESHLSELNTKLQEREREVHIL 1691
Query: 309 -RLLKLAESGNLNQLIEDFLAKEEKNFARFTYVTELNNDMEMMHKRTQRI---------Q 358
LK ES LI + + KN A +T E ++ + ++I +
Sbjct: 1692 EEKLKSVESSQSETLI---VPRSAKNVAAYTEQEEADSQGCVQKTYEEKISVLQRNLTEK 1748
Query: 359 DEIILLRSQQKLSHDDNHSVLR-QLEDKLRKTTEEADMYESKYGEVSKTLDLLKNSVEKL 417
++++ Q+K +H +R Q +++L K + E+K E + L+ +E+
Sbjct: 1749 EKLLQRVGQEKEETVSSHFEMRCQYQERLIK----LEHAEAKQHEDQSMIGHLQEELEEK 1804
Query: 418 FKK 420
KK
Sbjct: 1805 NKK 1807
Score = 31.2 bits (69), Expect = 2.6
Identities = 77/408 (18%), Positives = 162/408 (39%), Gaps = 76/408 (18%)
Query: 75 LLLSLMKSSRNMNRSEKNYMEL----RLLLQTKEDYEALI-----KSLKVLLAELDEKIL 125
L+ L + R+++ Y EL ++L + K+ + ++ KSL+ +AEL E+ L
Sbjct: 139 LIQRLRRMERSLSSYRGKYSELVTAYQMLQREKKKLQGILSQSQDKSLR-RIAELREE-L 196
Query: 126 QMEKKIAN--QKQIFAKMQEANNPRK-LQKQIHILETRLNLVTVHFDKMLTTNAKLRKEI 182
QM+++ Q++ A ++E + LQ Q+ +L+ RL ++ D +L +L +
Sbjct: 197 QMDQQAKKHLQEEFDASLEEKDQYISVLQTQVSLLKQRLRNGPMNVD-VLKPLPQLEPQA 255
Query: 183 EDLRFEKAAYDNVYQQLQHCLLMEKKTMNLAIEQSSQAYEQRVEAMARMAAMKDRQKKDT 242
E E E E VE + ++ Q++
Sbjct: 256 EVFTKE--------------------------ENPESDGEPVVEDGTSVKTLETLQQRVK 289
Query: 243 SQYNLEIRELERLYAHESKLKSFLLVKLNDRNEFEEQAKREEALKAKKHVKKNRGESFES 302
Q NL R E + +H+ + K + + +E+ + E +K +K +
Sbjct: 290 RQENLLKRCKETIQSHKEQCTLLTSEKEALQEQLDERLQELEKIKDLHMAEKTK------ 343
Query: 303 YEVAHLRLLKLAESGNLNQLIEDFLAKEEKNFARFTYVTELNNDMEMMHKRTQRIQDEII 362
+ +L ++ NL + +E ++K + MH+ + ++EI
Sbjct: 344 ------LITQLRDAKNLIEQLE-----QDKGMV-------IAETKRQMHETLEMKEEEIA 385
Query: 363 LLRSQQKLSHDDNHSVLRQLEDKLRKTTEEADMYESKYGEVSKTLDLLKNSVEKLFKKIN 422
LRS+ K + Q E R EE E KT E+ +K+
Sbjct: 386 QLRSRIKQMTTQGEELREQKEKSERAAFEE---LEKALSTAQKT--------EEARRKLK 434
Query: 423 CDATKILVQLGETGKVTDINLPQYFAIIEKKTNDLLLLETYRRILEVE 470
+ + + + +T + I+L Q + ++++ D++ + +I +++
Sbjct: 435 AEMDEQIKTIEKTSEEERISLQQELSRVKQEVVDVMKKSSEEQIAKLQ 482
>gi|239745089 PREDICTED: golgi autoantigen, golgin subfamily a-like
[Homo sapiens]
Length = 828
Score = 64.7 bits (156), Expect = 2e-10
Identities = 82/406 (20%), Positives = 181/406 (44%), Gaps = 54/406 (13%)
Query: 16 QEPSEKAKEQQAEAELRKLRQQFRKMVESRKSF----KFRNQQKIASQYKEIKTLKT--- 68
QE + +E++ + +LR++ +M E K + K + +++I + K+++ +
Sbjct: 350 QEQKMRDQEERMWEQDERLREKEERMREQEKMWEQEEKMQEEERIREREKKMREEEETMR 409
Query: 69 EQDEITLLLSLMKSSRNM-NRSEKNYMELRLLLQTKEDYEALIKSLKVLLAELDEKILQM 127
EQ+E + K NM + EK + + RL Q ++ +E + + E +EKI +
Sbjct: 410 EQEE-----KMQKQEENMWEQEEKEWQQQRLPEQKEKLWE------QEKMQEQEEKIWEQ 458
Query: 128 EKKIANQKQIFA---KMQEANNPRKLQKQIHILETRL----NLVTVHFDKMLTTNAKLRK 180
E+KI +Q++++ KM R+ + Q+ E ++ + ++M + +LR+
Sbjct: 459 EEKIRDQEEMWGQEKKMWRQEKMREQEDQMWEQEEKMRDQEQKMWDQEERMWEQDERLRE 518
Query: 181 EIEDLRFEKAAYDNVYQQLQHCLLMEKKTMNLAIEQSSQAYEQRVEAMARMAAMKDRQKK 240
+ E +R +K + Q + + EKKT EQ + ++Q E M M++R+KK
Sbjct: 519 KEERMREQKKMW-----QQEEKMREEKKTQ----EQEKKTWDQE-EKMREEERMREREKK 568
Query: 241 DTSQYNLEIRELERLYAHESKLKSFLLVKLNDRNEFEEQAKREEALKAKKHVKKNRGESF 300
+ + + E++ E K++ + +E++ K +E + ++ E
Sbjct: 569 MREEEEMMREQEEKMQEQEEKMRE------QEEKMWEQEEKMQEQEEKMWEQEEKMWEQE 622
Query: 301 ESYEVAHLRLLKLAESGNLNQLIEDFLAKEEKNFARFTYVTELNNDMEMMHKRTQRIQDE 360
E ++ + + + + E +EEK + E M ++ +++Q +
Sbjct: 623 EEDKMQEQEEMMWEQEEKMQEQEEKMWEQEEK----------MREQEEKMREQEEKMQGQ 672
Query: 361 IILLRSQQKLSHDDNHSVLRQLEDKLRKTTEEADMYESK-YGEVSK 405
+R Q++ +R+ E+K+R E+ E K +G+ K
Sbjct: 673 EEKMREQEEKMQGQEEK-MREQEEKMRGQEEKMWGQEEKMWGQEEK 717
Score = 57.8 bits (138), Expect = 3e-08
Identities = 86/410 (20%), Positives = 189/410 (46%), Gaps = 55/410 (13%)
Query: 5 KKNRRKDSDTPQEPSEKAKEQQAE--AELRKLRQQFRKMVESRKSFKFRNQQKIASQYKE 62
+K RK + E+ +EQ+ + + K+R+Q +++ E K + R Q+K + +E
Sbjct: 247 EKKIRKQEEKMWRQEERLREQEGKMREQEEKMRRQEKRLREQEK--ELREQEK---ELRE 301
Query: 63 IKTLKTEQDEITLLLSLMKSSRNMNRSEKNYM---ELRLLLQTKE--DYEALIKSLKVLL 117
K L+ +++++ M R ++ M E RL Q K+ + E ++ + +
Sbjct: 302 QKKLREQEEQMQEQEEKMWEQEEKMREQEEKMWRQEERLWEQEKQMREQEQKMRDQEERM 361
Query: 118 AELDEKILQMEKKIANQKQIF---AKMQEANNPRKLQKQIHILETRLNLVTVHFDKMLTT 174
E DE++ + E+++ Q++++ KMQE R+ +K++ E + M
Sbjct: 362 WEQDERLREKEERMREQEKMWEQEEKMQEEERIREREKKMREEE----------ETMREQ 411
Query: 175 NAKLRKEIEDLRFEKAAYDNVYQQL--QHCLLMEKKTMNLAIEQSSQAYEQRVEAMARMA 232
K++K+ E++ +E+ + Q+L Q L E++ M EQ + +EQ E +
Sbjct: 412 EEKMQKQEENM-WEQEEKEWQQQRLPEQKEKLWEQEKMQ---EQEEKIWEQE-EKIRDQE 466
Query: 233 AMKDRQKKDTSQYNLEIRELERLYAHESKLKSFLLVKLNDRNEFEEQAKREEALKAKKHV 292
M ++KK Q + +E ++++ E K++ K+ D+ E +++E L+ K+
Sbjct: 467 EMWGQEKKMWRQEKMREQE-DQMWEQEEKMRD-QEQKMWDQE--ERMWEQDERLREKEER 522
Query: 293 KKNRGESFESYEVAHLRLLKLAESGNLNQLIEDFLAKEEKNFARFTYVTELNNDMEMMHK 352
+ + + ++ E K+ E + + +EEK + E M +
Sbjct: 523 MREQKKMWQQEE-------KMREEKKTQEQEKKTWDQEEK-----------MREEERMRE 564
Query: 353 RTQRIQDEIILLRSQQKLSHDDNHSVLRQLEDKLRKTTEEADMYESKYGE 402
R +++++E ++R Q++ + +R+ E+K+ + E+ E K E
Sbjct: 565 REKKMREEEEMMREQEEKMQEQEEK-MREQEEKMWEQEEKMQEQEEKMWE 613
Score = 53.5 bits (127), Expect = 5e-07
Identities = 75/431 (17%), Positives = 181/431 (41%), Gaps = 61/431 (14%)
Query: 5 KKNRRKDSDTPQEPSEKAKEQQAEAELRKLRQQFRKMVESRKSF-------------KFR 51
+K RR++ ++ E ++++ E +KLR+Q +M E + +R
Sbjct: 276 EKMRRQEKRLREQEKELREQEKELREQKKLREQEEQMQEQEEKMWEQEEKMREQEEKMWR 335
Query: 52 NQQKIASQYKEIKTLKT----------EQDEITLLLSLMKSSRNMNRSEKNYMELRLLLQ 101
++++ Q K+++ + EQDE L + M EK + + +
Sbjct: 336 QEERLWEQEKQMREQEQKMRDQEERMWEQDE-----RLREKEERMREQEKMWEQ-----E 385
Query: 102 TKEDYEALIKSLKVLLAELDEKILQMEKKIANQKQIFAKMQEANNPRKLQKQIHILETRL 161
K E I+ + + E +E + + E+K+ Q++ + +E K +Q + E +
Sbjct: 386 EKMQEEERIREREKKMREEEETMREQEEKMQKQEENMWEQEE-----KEWQQQRLPEQKE 440
Query: 162 NLVTVHFDKMLTTNAKLRKEIEDLRFEKAAYDNVYQQLQHCLLMEKKTMNLAIEQSSQAY 221
L +KM K+ ++ E +R ++ + + + + E++ E+ +
Sbjct: 441 KL--WEQEKMQEQEEKIWEQEEKIRDQEEMWGQEKKMWRQEKMREQEDQMWEQEEKMRDQ 498
Query: 222 EQRVEAMARMAAMKDRQKKDTSQYNLEIRELERLYAHESKLKSFLLVKLNDRNEFEEQAK 281
EQ++ +D + ++ + +RE ++++ E K++ + ++ ++++ K
Sbjct: 499 EQKMWDQEERMWEQDERLREKEE---RMREQKKMWQQEEKMREEKKTQEQEKKTWDQEEK 555
Query: 282 REEALKAKKHVKKNRGES----------FESYEVAHLRLLKLAESGNLNQLIEDFLAKEE 331
E + ++ KK R E E E + K+ E Q E+ + ++E
Sbjct: 556 MREEERMREREKKMREEEEMMREQEEKMQEQEEKMREQEEKMWEQEEKMQEQEEKMWEQE 615
Query: 332 KNFARFTYVTELNNDMEMMHKRTQRIQDEIILLRSQQKLSHDDNHSVLRQLEDKLRKTTE 391
+ ++ EMM ++ +++Q++ ++K+ + +R+ E+K+R+ E
Sbjct: 616 EKMWEQEEEDKMQEQEEMMWEQEEKMQEQ------EEKMWEQEEK--MREQEEKMREQEE 667
Query: 392 EADMYESKYGE 402
+ E K E
Sbjct: 668 KMQGQEEKMRE 678
Score = 47.0 bits (110), Expect = 5e-05
Identities = 54/296 (18%), Positives = 123/296 (41%), Gaps = 38/296 (12%)
Query: 5 KKNRRKDSDTPQEPSEKAKEQQAEAELRKLRQQFRKMVESRKSFKFRNQQKIASQYKEIK 64
K ++D QE + +EQ+ + ++ +Q ++ E K + R Q+K+ Q ++++
Sbjct: 480 KMREQEDQMWEQEEKMRDQEQKMWDQEERMWEQDERLRE--KEERMREQKKMWQQEEKMR 537
Query: 65 TLKTEQDEITLLLSLMKSSRNMNRSEKNYMELRLLLQTKEDYEALIKSLKVLLAELDEKI 124
K Q++ + R R + ++R + + E ++ + + E +EK+
Sbjct: 538 EEKKTQEQEKKTWDQEEKMREEERMREREKKMREEEEMMREQEEKMQEQEEKMREQEEKM 597
Query: 125 LQMEKKIANQKQIF----AKMQEANNPRKLQKQIHILETRLNLVTVHFDKMLTTNAKLRK 180
+ E+K+ Q++ KM E K+Q+Q ++ + + +KM K+R+
Sbjct: 598 WEQEEKMQEQEEKMWEQEEKMWEQEEEDKMQEQEEMMWEQEEKMQEQEEKMWEQEEKMRE 657
Query: 181 EIEDLRFEKAAYDNVYQQLQHCLLMEKKTMNLAIEQSSQAYEQRVEAMARMAAMKDRQKK 240
+ E +R + E+K Q + EQ + + M+++++K
Sbjct: 658 QEEKMREQ-----------------EEKMQG----QEEKMREQEEKMQGQEEKMREQEEK 696
Query: 241 DTSQYNLEIRELERLYAHESKLKSFLLVKLNDRNEFEEQAKREEALKAKKHVKKNR 296
Q + E+++ E K+ EE ++EE ++ +K + R
Sbjct: 697 MRGQEEKMWGQEEKMWGQEEKMWG-----------QEEMREKEERIRDQKEKMQER 741
>gi|31563507 GRIP and coiled-coil domain-containing 2 [Homo sapiens]
Length = 1684
Score = 63.2 bits (152), Expect = 6e-10
Identities = 109/508 (21%), Positives = 212/508 (41%), Gaps = 90/508 (17%)
Query: 26 QAEAELRKLR----QQFRKMVESR-KSFKFRNQQKIASQYKEIKTLKTEQDEITLLLS-- 78
Q+ A+L +++ Q+ + MV+ ++ K + +QKI KE T E +E+ + L
Sbjct: 1079 QSNAKLLEVQILEVQRAKAMVDKELEAEKLQKEQKI----KEHATTVNELEELQVQLQKE 1134
Query: 79 ---LMKSSRNMNRSEKNYMELRLLLQTKEDYEALIKSLKVLLAELDEKILQMEKKIANQK 135
L K+ + + +K+ + L+ DYE L+K L L + KI +E++I QK
Sbjct: 1135 KKQLQKTMQELELVKKDAQQTTLMNMEIADYERLMKELNQKLTNKNNKIEDLEQEIKIQK 1194
Query: 136 QIFAKMQ-EANNPRKLQKQIHILETRLNLVTVHFDKMLTTN-----------AKLRKEIE 183
Q +Q E + + +Q T++ + V K L + A L+ E+E
Sbjct: 1195 QKQETLQEEITSLQSSVQQYEEKNTKIKQLLVKTKKELADSKQAETDHLILQASLKGELE 1254
Query: 184 DLRFEKAAYDNVYQQL---QHCLLMEKKTMNLAIEQSSQAYEQRVEAM-ARMAAMKDRQK 239
+ + Y ++ +H + KT +++ AY+QRV A+ A K Q
Sbjct: 1255 ASQQQVEVYKIQLAEITSEKHKIHEHLKTSAEQHQRTLSAYQQRVTALQEECRAAKAEQA 1314
Query: 240 KDTSQYNLEIRELERLYAHESKLKSFLLVKLNDRNEFEEQAKREEALKAKKH-------- 291
TS++ E ++ H V +N+ QA+ E A + ++H
Sbjct: 1315 TVTSEF-----ESYKVRVHN--------VLKQQKNKSMSQAETEGAKQEREHLEMLIDQL 1361
Query: 292 -VKKNRGESFESYEVAHLRLLKLAESGNL---NQLIEDFLAKEEKNFARFTYVTELNNDM 347
+K ++ V+ L+ L+ L N+++++ ++KE + + + N M
Sbjct: 1362 KIKLQDSQNNLQINVSELQTLQSEHDTLLERHNKMLQETVSKEAELREKLCSIQSENMMM 1421
Query: 348 EMMHKRTQRIQDEIILLRSQQKLSHDDNHSVLRQLEDKLRKTTE---------EADMYES 398
+ H +T + L SQ ++ + +R L+++ RKT E EA +++
Sbjct: 1422 KSEHTQT------VSQLTSQNEVLRNSFRDQVRHLQEEHRKTVETLQQQLSKMEAQLFQL 1475
Query: 399 KYGEVSKTLDLLKNSVEKLFKKINCDAT-----KILVQLGETGKVTDINLPQYFAIIEKK 453
K +++ + S++ L ++ N D + + GE + TD
Sbjct: 1476 KNEPTTRSPVSSQQSLKNLRERRNTDLPLLDMHTVTREEGEGMETTD------------- 1522
Query: 454 TNDLLLLETYRRILE--VEGAEAEIPPP 479
T + TY + LE + E ++ PP
Sbjct: 1523 TESVSSASTYTQSLEQLLNSPETKLEPP 1550
Score = 60.1 bits (144), Expect = 5e-09
Identities = 100/485 (20%), Positives = 202/485 (41%), Gaps = 55/485 (11%)
Query: 26 QAEAELRKLRQQFRKMVESRKSFKFRNQQKIASQYKEIKTLKTEQDEITLLLSLMKSSRN 85
Q +EL + + +E K +N QK+ ++K L +++ ++ + + N
Sbjct: 636 QYNSELEQKVNELTGGLEETLKEKDQNDQKLEKLMVQMKVLSEDKEVLSAEVKSLYEENN 695
Query: 86 MNRSEKNYM--ELRLLLQTKED------YEALIKSLKVLLAELD--EKILQME--KKIAN 133
SEK + +L + L KED L K L++++ E D K+L+ E +K+
Sbjct: 696 KLSSEKKQLSRDLEVFLSQKEDVILKEHITQLEKKLQLMVEEQDNLNKLLENEQVQKLFV 755
Query: 134 QKQIFAKMQ----EANNPRKLQKQIHIL-----------ETRLNLVTVHFDKMLTTNAKL 178
+ Q++ ++ E + + + +++L E + NL +K+L +L
Sbjct: 756 KTQLYGFLKEMGSEVSEDSEEKDVVNVLQAVGESLAKINEEKCNLAFQRDEKVL----EL 811
Query: 179 RKEIEDLRFEKAAYDNVYQQLQHCLLMEKKTMNLAIEQSSQAYEQRVEAMARMAAMKDRQ 238
KEI+ L+ E + L EK + +E+ E + M ++
Sbjct: 812 EKEIKCLQEESVVQCEELKSLLRDYEQEKVLLRKELEEIQSEKEALQSDLLEMKNANEKT 871
Query: 239 KKDTSQYNLEIRELERLYA----HESKLKSFLLVKLNDRNEFEEQAKREEALKAKKHVKK 294
+ + +++ E+ + + H K K F+ N + E++ R+ +A+ + K
Sbjct: 872 RLENQNLLIQVEEVSQTCSKSEIHNEKEKCFIKEHENLKPLLEQKELRDR--RAELILLK 929
Query: 295 NRGESFESYEVAHLRLLKLAESGNLNQLIEDFLAKEEKNFARFTYVTELNNDMEMMHKRT 354
+ S + L +K E + L ++ KEEK + +++ K T
Sbjct: 930 DSLAKSPSVKNDPLSSVKELEE-KIENLEKECKEKEEKINKIKLVAVKAKKELDSSRKET 988
Query: 355 QRIQDEIILLRSQQKLSHDDNHSVLRQLEDKLRKTTEEADMYES---KYGEVSKTLDLLK 411
Q +++E+ LRS++ QL +R + A+ Y++ +Y + S+ LD+ K
Sbjct: 989 QTVKEELESLRSEKD-----------QLSASMRDLIQGAESYKNLLLEYEKQSEQLDVEK 1037
Query: 412 NSVEKLFKKINCDATKILVQLGETGKVTDINLPQYFAIIEKKTNDLLLLETYRRILEVEG 471
+I D T+ L + + + A IE ++ LLE +ILEV+
Sbjct: 1038 ERANNFEHRIE-DLTRQLRNSTLQCETINSDNEDLLARIETLQSNAKLLEV--QILEVQR 1094
Query: 472 AEAEI 476
A+A +
Sbjct: 1095 AKAMV 1099
Score = 52.4 bits (124), Expect = 1e-06
Identities = 89/446 (19%), Positives = 190/446 (42%), Gaps = 78/446 (17%)
Query: 23 KEQQAEAELRKLRQQFRKMVESRKSFKFRNQQKIASQYKEIKTLKTEQDEITLLLSLMKS 82
K + E E++ L+++ E KS +Q+ KE++ +++E++ + L MK+
Sbjct: 807 KVLELEKEIKCLQEESVVQCEELKSLLRDYEQEKVLLRKELEEIQSEKEALQSDLLEMKN 866
Query: 83 SRNMNRSEKNYMELRLLLQTKEDYEALIKS----------------LKVLLAELD----- 121
+ R E LL+Q +E + KS LK LL + +
Sbjct: 867 ANEKTRLENQ----NLLIQVEEVSQTCSKSEIHNEKEKCFIKEHENLKPLLEQKELRDRR 922
Query: 122 EKILQMEKKIANQKQIFAKMQEANNPRKLQKQIHILE----------TRLNLVTVHFDKM 171
+++ ++ +A + K ++ ++L+++I LE ++ LV V K
Sbjct: 923 AELILLKDSLAKSPSV--KNDPLSSVKELEEKIENLEKECKEKEEKINKIKLVAVKAKKE 980
Query: 172 LTTNAK----LRKEIEDLRFEK----AAYDNVYQQLQH----CLLMEKKTMNLAIE-QSS 218
L ++ K +++E+E LR EK A+ ++ Q + L EK++ L +E + +
Sbjct: 981 LDSSRKETQTVKEELESLRSEKDQLSASMRDLIQGAESYKNLLLEYEKQSEQLDVEKERA 1040
Query: 219 QAYEQRVEAMARMAAMKDRQ-------------KKDTSQYNLEIRELERLYAHESKL--- 262
+E R+E + R Q + +T Q N ++ E++ L +K
Sbjct: 1041 NNFEHRIEDLTRQLRNSTLQCETINSDNEDLLARIETLQSNAKLLEVQILEVQRAKAMVD 1100
Query: 263 KSFLLVKLNDRNEFEEQAKREEAL--------KAKKHVKKNRGESFESYEVAHLRLLKLA 314
K KL + +E A L K KK ++K E + A L
Sbjct: 1101 KELEAEKLQKEQKIKEHATTVNELEELQVQLQKEKKQLQKTMQELELVKKDAQQTTLMNM 1160
Query: 315 ESGNLNQLIEDFLAKEEKNFARFTYVTELNNDMEMMHKRTQRIQDEIILLRSQQKLSHDD 374
E + +L+++ +K + + +L ++++ ++ + +Q+EI L+S + +++
Sbjct: 1161 EIADYERLMKEL---NQKLTNKNNKIEDLEQEIKIQKQKQETLQEEITSLQSSVQ-QYEE 1216
Query: 375 NHSVLRQLEDKLRKTTEEADMYESKY 400
++ ++QL K +K ++ E+ +
Sbjct: 1217 KNTKIKQLLVKTKKELADSKQAETDH 1242
Score = 52.0 bits (123), Expect = 1e-06
Identities = 105/523 (20%), Positives = 226/523 (43%), Gaps = 95/523 (18%)
Query: 4 LKKNRRKDSDTPQEPSEKAKEQQ-AEAELRKLRQQFRKMVESRKSFKFRNQQKIASQYKE 62
L+K + +T E SE+ K Q +E ++KL+++ K+ R F+ +Q + Q +
Sbjct: 152 LQKQLEEAMNTQLELSEQLKFQNNSEDNVKKLQEEIEKI---RPGFE---EQILYLQKQL 205
Query: 63 IKTLKTEQDEITLLLSLMKSS-----RNMNRSEKNYMELRLLLQTK------------ED 105
T +++ +T L ++++++ +N+N ++ ++L+ + Q + ++
Sbjct: 206 DATTDEKKETVTQLQNIIEANSQHYQKNINSLQEELLQLKAIHQEEVKELMCQIEASAKE 265
Query: 106 YEALIKSLKVLLAELDEKILQMEKKIANQKQI-FAKMQEANNPRKLQKQI--------HI 156
+EA I L L L ++ EK I + + +++A + QI
Sbjct: 266 HEAEINKLNELKENLVKQCEASEKNIQKKYECELENLRKATSNANQDNQICSILLQENTF 325
Query: 157 LETRLNLVTVHFDKML----TTNAKLRKEIEDLRFEKAAYDNVYQQLQHCLLMEKKTMNL 212
+E +N H + L + ++ L+ E+ + K + Q ++ E++ +
Sbjct: 326 VEQVVNEKVKHLEDTLKELESQHSILKDEVTYMNNLKLKLEMDAQHIKDEFFHEREDLEF 385
Query: 213 AIEQSSQAYEQR---VEAM-ARMAAMKDRQKKDTSQYNLEIRELERLYAHESKLKSFLLV 268
I + A E++ +E + + +A + + Q+N E++ L+ H+ ++
Sbjct: 386 KINELLLAKEEQGCVIEKLKSELAGLNKQFCYTVEQHNREVQSLKE--QHQKEISELNET 443
Query: 269 KLNDRNE------FEEQAKREEALKAKKHVKKNRGESFESYE----VAHLRLLKLAES-G 317
L+D + FE Q +E+ +++++ + E+ +YE + + +L ES G
Sbjct: 444 FLSDSEKEKLTLMFEIQGLKEQC----ENLQQEKQEAILNYESLREIMEILQTELGESAG 499
Query: 318 NLNQLIEDFLAKEEKNFARFTY-VTELNNDMEMMHKRTQRIQDEIILLRSQQKL------ 370
++Q E ++ + + + + + + R+Q E L SQQ+L
Sbjct: 500 KISQEFESMKQQQASDVHELQQKLRTAFTEKDALLETVNRLQGENEKLLSQQELVPELEN 559
Query: 371 --------------SHDDNHSVLRQLEDKLRKTTEEADMYESKYGEVSKTLDLLKNSVEK 416
S ++L++LE K+ TEE D + +K LKNS E+
Sbjct: 560 TIKNLQEKNGVYLLSLSQRDTMLKELEGKINSLTEEKDDFINK----------LKNSHEE 609
Query: 417 L--FKKINCDATKILVQLGETGKVTDINLPQYFAIIEKKTNDL 457
+ F K C+ + L+ E GK + + QY + +E+K N+L
Sbjct: 610 MDNFHK-KCEREERLIL--ELGKKVEQTI-QYNSELEQKVNEL 648
>gi|221219020 NYD-SP11 protein [Homo sapiens]
Length = 2873
Score = 63.2 bits (152), Expect = 6e-10
Identities = 93/420 (22%), Positives = 185/420 (44%), Gaps = 42/420 (10%)
Query: 16 QEPSEKAKEQQAEA-ELRKLRQQFRKMVESRKSFKFRNQQKIASQYKEIKTLK---TEQD 71
+E ++ A+E++ E KL Q KM E + + +Q I + K + + +
Sbjct: 1765 EEETKLAQEEELLIQEKEKLAQHKEKMPEEEERLGRKREQLIEKKMKLAQKRERWINSME 1824
Query: 72 EITLLLSLMKSSRNMNRSEKNY-MELRLLLQTKEDYEALIKSLKVLLAELDEKILQMEKK 130
E+T ++ +N+ + +KN E L Q KE+ + K L ++++Q++ K
Sbjct: 1825 ELTKNKMILYQKKNLAQEKKNLAQEKEKLAQRKEN----LLYNKERLTHSKKQLVQVKNK 1880
Query: 131 IANQKQIFAKMQEANNPRK---LQKQIHILETRLNLVTVHFDKMLTTNAKLRKEIEDLRF 187
+ +I A+++E K ++K+ + ET LV V D + KL +E L
Sbjct: 1881 LGMFNKILAQVEEKLTQEKETVIKKKEKLAETEKKLVQVE-DSLAKKQEKLAQEKMKLAL 1939
Query: 188 EKAAYDNVYQQLQHC-LLMEKKTMNLAIEQSSQAYEQRVEAMARMAAMK----DRQKKDT 242
EKA + + E+K +NL +++ ++ + VE ++ + RQ+K T
Sbjct: 1940 EKAMVQGKKRLRGELDIAKEEKALNLEMKRLAEEKMRLVEGKETLSKGETPETSRQRKMT 1999
Query: 243 S-QYNLEIREL---ERLYAHESKLKSFLLVKL-NDRNEFEE------QAKREEALKAKKH 291
+ L R+L E++ HE ++ + ++ + EF Q +R+ A ++K
Sbjct: 2000 QVEQELFERKLSLEEKILLHEDRILAMEESEIAKGKLEFTRGQRIFVQGQRKLAKASRKL 2059
Query: 292 VKKNRGESFESYEVAHLRLLKLAESGNLNQLIEDFLAKEEKNFARFTYVTELN------- 344
+KK S E ++ + + + +L ++ + + A F L+
Sbjct: 2060 IKKRESLSKEPAKLNKILKALQKLTRDERKLTQEEIKMTKMKRALFVKERRLSIEQSKLD 2119
Query: 345 -NDMEMMHKRTQRIQDEIILLRSQQKLSHDDNHSVLRQLEDKLRKTTEEADMYESKYGEV 403
+ + KR++ +DE L R Q+KL++ +R++ +K K TEE K+ EV
Sbjct: 2120 IKEWDFSEKRSELTKDEKKLARKQRKLANK-----MRRMINKEEKMTEEESKLARKHSEV 2174
Score = 62.0 bits (149), Expect = 1e-09
Identities = 89/441 (20%), Positives = 187/441 (42%), Gaps = 46/441 (10%)
Query: 5 KKNRRKDSDTPQEPSEKAKEQQAEAELRKLRQQFRKMVESRKSFKFRNQQKIASQYKEIK 64
K ++ D + E+ ++ E + +++ ++ R + E K + ++ A + + +
Sbjct: 1532 KSKEQQYKDEEEVTLEEEVSREGEEKEQQVTEEQRHIQEEHKWARIHRKRARAEKKRAQE 1591
Query: 65 TLKTEQDEITLLLSLMKSSRNMNRSEKNYMELRLLLQTKEDYEALIKSLKVLLAELDEKI 124
K Q+E L + ++ + + Y+++ + E + LA+ EK+
Sbjct: 1592 ERKLAQEEEKLAQEERQLAQEERKLAQAYVKITQDDREMAQAEGKFAQKEETLAQRGEKL 1651
Query: 125 LQMEKKIANQKQIFAKMQE---------ANNPRKLQKQIHILETRLNLVTVHFDKMLTTN 175
Q +K+A +++ AK E A KL + +IL ++ + +
Sbjct: 1652 SQEAEKLAQKRKKLAKKWEKVAREEEKLAKKGGKLAEVKNILAQKVEELPQREQNLDWQE 1711
Query: 176 AKLRKEIEDLRF---EKAAYDNVYQQLQHCLLMEKKTMNLAIEQSSQAYEQRVEAMARMA 232
+L +E+E+L + E + + Q + L+ EKK LA E+ + A+++
Sbjct: 1712 KELAQELEELEWDMEELSWKEEELNQEEGKLVEEKK--KLAEEEEALAWQRE-------- 1761
Query: 233 AMKDRQKKDTSQYNLEIRELERLYAHESKLKSFLLVKLNDRNEFEEQA--KREEALKAKK 290
+ + + K + L I+E E+L H+ K+ E EE+ KRE+ ++ K
Sbjct: 1762 KLSEEETKLAQEEELLIQEKEKLAQHKEKMP-----------EEEERLGRKREQLIEKKM 1810
Query: 291 HVKKNRGESFESYEVAHLRLLKLAESGNLNQLIEDFLAKEEKNFARFTYVTELNNDMEMM 350
+ + R S E + L + NL Q ++ ++EK R + L N +
Sbjct: 1811 KLAQKRERWINSMEELTKNKMILYQKKNLAQEKKNLAQEKEKLAQRKENL--LYNKERLT 1868
Query: 351 HKRTQRIQDEIILLRSQQKLSHDDNHSVLRQLEDKLRKTTEEADMYESKYGEVSKTLDLL 410
H + Q +Q + KL + +L Q+E+KL + E + K E K L +
Sbjct: 1869 HSKKQLVQ-------VKNKLGMFNK--ILAQVEEKLTQEKETVIKKKEKLAETEKKLVQV 1919
Query: 411 KNSVEKLFKKINCDATKILVQ 431
++S+ K +K+ + K+ ++
Sbjct: 1920 EDSLAKKQEKLAQEKMKLALE 1940
Score = 53.5 bits (127), Expect = 5e-07
Identities = 92/442 (20%), Positives = 188/442 (42%), Gaps = 63/442 (14%)
Query: 6 KNRRKDSDTPQEPSEKAKEQQAEAEL-RKLRQQFRKMVESRKSFKFRNQQKIASQYKEIK 64
K + D + Q + A++++ A+ KL Q+ K+ + RK + +K+A + +++
Sbjct: 1622 KITQDDREMAQAEGKFAQKEETLAQRGEKLSQEAEKLAQKRKKLA-KKWEKVAREEEKLA 1680
Query: 65 TLKTEQDEITLLLS-----LMKSSRNMNRSEKNYMELRLLLQTKEDYEALIKSLKVLLAE 119
+ E+ +L+ L + +N++ EK L Q E+ E ++ L E
Sbjct: 1681 KKGGKLAEVKNILAQKVEELPQREQNLDWQEKE------LAQELEELEWDMEELSWKEEE 1734
Query: 120 LDE---KILQMEKKIANQKQIFAKMQE--ANNPRKLQKQIHILETRLNLVTVHFDKMLTT 174
L++ K+++ +KK+A +++ A +E + KL ++ +L + H +KM
Sbjct: 1735 LNQEEGKLVEEKKKLAEEEEALAWQREKLSEEETKLAQEEELLIQEKEKLAQHKEKMPEE 1794
Query: 175 NAKLRKEIEDLRFEKAA-------YDNVYQQLQHCLLMEKKTMNLAIEQSSQAYEQRVEA 227
+L ++ E L +K + N ++L ++ + NLA E+ + A E+
Sbjct: 1795 EERLGRKREQLIEKKMKLAQKRERWINSMEELTKNKMILYQKKNLAQEKKNLAQEKE--- 1851
Query: 228 MARMAAMKDRQKKDTSQYNLEIRELERLYAHESKLKSFLLVKLNDRNEFEEQAKREEALK 287
K Q+K+ YN E RL H K + KL N+ Q + + +
Sbjct: 1852 -------KLAQRKENLLYNKE-----RL-THSKKQLVQVKNKLGMFNKILAQVEEKLTQE 1898
Query: 288 AKKHVKKNRGESFESYEVAHLRLLKLAESGNLNQLIEDFLAKEEKNFARFTYVTELNNDM 347
+ +KK KLAE+ +ED LAK+++ A+ L M
Sbjct: 1899 KETVIKKKE---------------KLAETEKKLVQVEDSLAKKQEKLAQEKMKLALEKAM 1943
Query: 348 EMMHKRTQRIQDEIILLRSQQKLSHDDNHSVLRQLEDKLRKTTEEADMYESKYGEVSKTL 407
K R++ E+ + + ++ L N + R E+K+R + + + + E S+
Sbjct: 1944 VQGKK---RLRGELDIAKEEKAL----NLEMKRLAEEKMRLVEGKETLSKGETPETSRQR 1996
Query: 408 DLLKNSVEKLFKKINCDATKIL 429
+ + E +K++ + +L
Sbjct: 1997 KMTQVEQELFERKLSLEEKILL 2018
Score = 39.3 bits (90), Expect = 0.010
Identities = 67/337 (19%), Positives = 147/337 (43%), Gaps = 39/337 (11%)
Query: 32 RKLRQQFRKMVESRKSFKFRNQQKIASQYKEIKTLKTEQDEITLLLSLMKSSRNMNRSEK 91
RKL + RK+++ R+S ++ A K +K L+ L + R + + E
Sbjct: 2050 RKLAKASRKLIKKRESLS----KEPAKLNKILKALQ----------KLTRDERKLTQEEI 2095
Query: 92 NYMELRLLLQTKEDYEALIKSLKVLLAELD-----EKILQMEKKIAN-QKQIFAKMQEAN 145
+++ L KE ++ +S K+ + E D ++ + EKK+A Q+++ KM+
Sbjct: 2096 KMTKMKRALFVKERRLSIEQS-KLDIKEWDFSEKRSELTKDEKKLARKQRKLANKMR--- 2151
Query: 146 NPRKLQKQIHILETRLNLVTVHFDKMLTTNAKLRKEIED-LRFEKAAYDNVYQQLQHCLL 204
R + K+ + E L H + +L + E E+ + F K + + +
Sbjct: 2152 --RMINKEEKMTEEESKLARKHSEVILDDEEEGGIEEEEVIPFLKRRWRKRKEAKRGDKP 2209
Query: 205 MEKKTMNLAIEQSSQAYEQRVEAMARMAAMKDRQKKDTSQYNLEIRELERLYAHESKLKS 264
EK + + +S + + + +E++ + + +K+++ E E E +++
Sbjct: 2210 KEKFSSQVDEVESEEHFSEEMESL-----LDELEKQESLSSEEEEEREEEEEREEEEVRE 2264
Query: 265 FLLVKLNDRNEFEEQAKREEALKAKKHVKKNRGESFESYEVAHLRLLKLAESGNLNQLIE 324
+ + E+Q ++EE K KK +K + E E EV + ++E
Sbjct: 2265 EEEERKEEEEGEEKQVEKEEEEKKKKKKEKKKEEVQEKEEVFEEKEEIMSEEET------ 2318
Query: 325 DFLAKEEKNFARFTYVTELNNDMEMMHKRTQ-RIQDE 360
+ L+ EE+ + E++ + E++ K Q ++Q++
Sbjct: 2319 ESLSDEEEEEESCSLEEEVDREKEILKKEKQFKLQEQ 2355
Score = 32.0 bits (71), Expect = 1.6
Identities = 31/163 (19%), Positives = 76/163 (46%), Gaps = 24/163 (14%)
Query: 2 SVLKKNRRKDSDTPQEPSEKAKEQQAEAELRKLRQQFRKMVESRKSFKFRNQQKIASQYK 61
S+L + +++S + +E E+ +E++ E E + R+ E RK + ++++ + +
Sbjct: 2232 SLLDELEKQESLSSEEEEEREEEEEREEE------EVREEEEERKEEEEGEEKQVEKEEE 2285
Query: 62 EIKTLKTEQDEITLLLSLMKSSRNMNRSEKNYMELRLLLQTKEDYEALIKSLKVLLAELD 121
E K K E K + E+ + E ++ ++E+ E+L E +
Sbjct: 2286 EKKKKKKE-----------KKKEEVQEKEEVFEEKEEIM-SEEETESLSDE------EEE 2327
Query: 122 EKILQMEKKIANQKQIFAKMQEANNPRKLQKQIHILETRLNLV 164
E+ +E+++ +K+I K ++ + +K + E L+++
Sbjct: 2328 EESCSLEEEVDREKEILKKEKQFKLQEQRRKSLRGRERVLSIL 2370
>gi|38045896 RAB6-interacting protein 2 isoform delta [Homo sapiens]
Length = 1088
Score = 63.2 bits (152), Expect = 6e-10
Identities = 90/475 (18%), Positives = 215/475 (45%), Gaps = 47/475 (9%)
Query: 4 LKKNRRKDSDTPQEPSEKAKEQQAEAELRKLRQQFRKMVESRKSFKFRNQQKIASQYKEI 63
L + + K++ +E + E ++ K Q +M +S+ S R + + + + +
Sbjct: 349 LLEQKEKENSMLREEMHRRFENAPDSAKTKALQTVIEMKDSKISSMERGLRDLEEEIQML 408
Query: 64 KT---LKTEQDEITLLLSLMKSSRNMNRSEKNYMELRLLLQTKEDYEALIKSLKVLLAEL 120
K+ L TE+ E + + RS +M+ ++ Q K++ L + LLA L
Sbjct: 409 KSNGALSTEEREEEM------KQMEVYRSHSKFMKNKIG-QVKQE---LSRKDTELLA-L 457
Query: 121 DEKILQMEKKIANQKQIFAKMQEANNPRKLQKQIHILETRLNLVTVHFDKMLTTNAKLRK 180
K+ + + ++ KQ ++E+ + +++ IL+T ++ + + ++ T K K
Sbjct: 458 QTKLETLTNQFSDSKQHIEVLKESLTAK--EQRAAILQTEVDALRLRLEEKETMLNKKTK 515
Query: 181 EIEDLRFEKAAYDNVYQQLQHCLLMEKKTMNLAIEQSSQAYEQRVEAMARMAAMKDRQKK 240
+I+D+ EK L+ L ++++ +N+ ++ EQ + +M+++K+R K
Sbjct: 516 QIQDMAEEKGTQAGEIHDLKDMLDVKERKVNVLQKKIENLQEQLRDKEKQMSSLKERVKS 575
Query: 241 ---DTSQYNLEIRELERLYAHESKLKSFLLVKLNDRNEFEEQAKREEALKAKKHVKKNRG 297
DT+ + + LE A + + + +L ++ + +E+ K+EE KK +K +
Sbjct: 576 LQADTTNTDTALTTLEEALAEKER----TIERLKEQRDRDEREKQEEIDNYKKDLKDLKE 631
Query: 298 ESFESYEVAHLRLLKLAESGNLNQLIEDFLAKEEKNFARFTYVTELNNDMEMMHKRTQRI 357
+ + LL+ G+L++ L +E + + + ++ ++ + ++
Sbjct: 632 K---------VSLLQ----GDLSEKEASLLDLKEHASSLASSGLKKDSRLKTLEIALEQK 678
Query: 358 QDEIILLRSQQKLSHDD--NHSVLRQLEDKLRKTTEEADMYESKYGEVSKTLDLLKNSVE 415
++E + + SQ K +H+ ++ D+++ E Y+ + + +D L ++
Sbjct: 679 KEECLKMESQLKKAHEAALEARASPEMSDRIQHLEREITRYKDESSKAQAEVDRLLEILK 738
Query: 416 KLFKKINCDATKILVQL-----GETGKVTDINLPQYFAIIEKKTNDLLLLETYRR 465
++ + N D K + +L + KV ++ + +EKK + +L E RR
Sbjct: 739 EVENEKN-DKDKKIAELERQVKDQNKKVANLKHKEQ---VEKKKSAQMLEEARRR 789
Score = 46.2 bits (108), Expect = 8e-05
Identities = 82/402 (20%), Positives = 176/402 (43%), Gaps = 48/402 (11%)
Query: 1 MSVLKKNRRK-DSDTPQEPSEKAKEQQAEAELRKLRQQFRKMVESRKSFKFRNQQKIASQ 59
MS LK+ + +DT + ++A AE + ++ + E R + Q++I +
Sbjct: 566 MSSLKERVKSLQADTTNTDTALTTLEEALAEKERTIERLK---EQRDRDEREKQEEIDNY 622
Query: 60 YKEIKTLKTEQDEITLLLSLMKSSRNMNRSEKNYMELR----LLLQTKEDYEALIKSLKV 115
K++K LK ++++LL +++ E + ++L+ L + ++ +K+L++
Sbjct: 623 KKDLKDLK---EKVSLLQG------DLSEKEASLLDLKEHASSLASSGLKKDSRLKTLEI 673
Query: 116 LLAELDEKILQMEKKIANQKQIFAKMQEANNPRKLQKQIHILETRLNLVTVHFDKMLTTN 175
L + E+ L+ME ++ K+ EA ++ +I LE +T + D+
Sbjct: 674 ALEQKKEECLKMESQL---KKAHEAALEARASPEMSDRIQHLERE---ITRYKDESSKAQ 727
Query: 176 AKLRKEIEDLRFEKAAYDNVYQQLQHCLLMEKKTMNLAIEQSSQAYEQRVEAMARMAAMK 235
A++ + +E L+ ++++ EK + I + + + + + +A + +
Sbjct: 728 AEVDRLLEILK-----------EVEN----EKNDKDKKIAELERQVKDQNKKVANLKHKE 772
Query: 236 DRQKKDTSQYNLEIRELERLYAHESKLKSFLLVKLNDRNEFEEQAKREEA-LKAKKHVKK 294
+KK ++Q E R E S+ L K +DR E E+A RE + A++ +
Sbjct: 773 QVEKKKSAQMLEEARRREDNLNDSSQQLQDSLRKKDDRIEELEEALRESVQITAEREMVL 832
Query: 295 NRGESFESYEVAHLRLLKLAESGNLNQLIEDFLAK----EEKNFARFTYVTELNNDMEMM 350
+ ES + + L +A + Q +E AK ++ + T++T L +
Sbjct: 833 AQEESARTNAEKQVEELLMAME-KVKQELESMKAKLSSTQQSLAEKETHLTNLRAERRKH 891
Query: 351 HKRTQRIQDEIILLRSQQKLSHDDNHSVLRQLEDKLRKTTEE 392
+ ++ E +L +S D + L +L +KT EE
Sbjct: 892 LEEVLEMKQEALL----AAISEKDANIALLELSSSKKKTQEE 929
Score = 43.9 bits (102), Expect = 4e-04
Identities = 63/294 (21%), Positives = 123/294 (41%), Gaps = 50/294 (17%)
Query: 150 LQKQIHILETRL----NLVTVHFDKMLTTNAKLRK-EIEDLRFEKAAYDNVYQQLQHCLL 204
L+K + + E++L N + + L LRK E + K Y V ++ QH
Sbjct: 168 LRKDVEVKESKLSSSMNSIKTFWSPELKKERALRKDEASKITIWKEQYRVVQEENQH--- 224
Query: 205 MEKKTMNLAIEQSSQAYEQRVEAMARMAAMKDRQKKDTSQYNLEIRE--LERLYA-HESK 261
M + I+ E R++ +D + E+ E +RL+A HE +
Sbjct: 225 -----MQMTIQALQD--ELRIQRDLNQLFQQDSSSRTGEPCVAELTEENFQRLHAEHERQ 277
Query: 262 LKSFLLVK-----LNDRNEFEEQA--KREEALKAKKHVKKNRGESFESYEVAHLRLLKLA 314
K L++ + R E ++Q R+E++K + +++G S ++ E H R +LA
Sbjct: 278 AKELFLLRKTLEEMELRIETQKQTLNARDESIKKLLEMLQSKGLSAKATEEDHERTRRLA 337
Query: 315 ESGNLNQLIEDFLAKEEKN--------FARF-------------TYVTELNNDMEMMHKR 353
E+ +E L ++EK RF T + ++ + M +
Sbjct: 338 EAEMHVHHLESLLEQKEKENSMLREEMHRRFENAPDSAKTKALQTVIEMKDSKISSMERG 397
Query: 354 TQRIQDEIILLRSQQKLSHDDNHSVLRQLEDKLRKTTEEADMYESKYGEVSKTL 407
+ +++EI +L+S LS ++ ++Q+E + ++K G+V + L
Sbjct: 398 LRDLEEEIQMLKSNGALSTEEREEEMKQME----VYRSHSKFMKNKIGQVKQEL 447
>gi|50897852 coiled-coil domain containing 88A isoform 2 [Homo
sapiens]
Length = 1843
Score = 63.2 bits (152), Expect = 6e-10
Identities = 99/440 (22%), Positives = 189/440 (42%), Gaps = 72/440 (16%)
Query: 19 SEKAKEQQAEAELRKLRQQFRKMVESRKSFKFRNQQKIASQYKEI---------KTLKTE 69
SEK K QQ +L KL + K+ +++ Q S+YK + K+L+ +
Sbjct: 913 SEKLKTQQMNNDLEKLTHELEKIGLNKERLLHDEQSTDDSRYKLLESKLESTLKKSLEIK 972
Query: 70 QDEITLLLSLMKSSRNMNRSEKNYMELRLLLQT-KEDYEALIKSLKVLLAELDEKILQME 128
+++I L + ++ S N N+ +LR L+T K++YEAL + + +E+++Q
Sbjct: 973 EEKIAALEARLEESTNYNQ------QLRQELKTVKKNYEALKQ------RQDEERMVQSS 1020
Query: 129 KKIANQKQIFAKMQEANNPRKLQKQIHILETRLNLVTVHFDK---------MLTTNAKLR 179
I+ + + + + L+ + ++E N T+ +K + T N L+
Sbjct: 1021 PPISGEDNKWERESQETTRELLKVKDRLIEVERNNATLQAEKQALKTQLKQLETQNNNLQ 1080
Query: 180 KEIEDLRFEKAAY--DNVYQQLQHC-LLMEKKTMNLAIEQSSQAYEQRVEAMARMAAMKD 236
+I L+ + + N Q Q+ L +E T+N QS+ Q + + + +++++
Sbjct: 1081 AQILALQRQTVSLQEQNTTLQTQNAKLQVENSTLN---SQSTSLMNQNAQLLIQQSSLEN 1137
Query: 237 RQKKDTSQYNLEIRELERLYAHESKLKSFLLVKLNDRNEF--EEQAKREEALKAK----K 290
+ E +L+ LY L+K +++ E E QA E+L +K K
Sbjct: 1138 ENESVIK----EREDLKSLYDS--------LIKDHEKLELLHERQASEYESLISKHGTLK 1185
Query: 291 HVKKNRGESFESYEVAHLRLLKLAESGNLNQLIEDFLAKEEK----NFARFTYVTEL--- 343
KN E + +LLK + G L L + ++EK N T E
Sbjct: 1186 SAHKNLEVEHRDLEDRYNQLLK--QKGQLEDLEKMLKVEQEKMLLENKNHETVAAEYKKL 1243
Query: 344 --NNDMEMMHKRTQRIQDEIILLRSQQKLSHDDNHSVLRQLE-----DKLRKTTEEADMY 396
ND + H +Q +++ +L + L N+S L Q KL++ ++ D+
Sbjct: 1244 CGEND-RLNHTYSQLLKETEVLQTDHKNLKSLLNNSKLEQTRLEAEFSKLKEQYQQLDIT 1302
Query: 397 ESKYGEVSKTLDLLKNSVEK 416
+K + L LK ++E+
Sbjct: 1303 STKLNNQCELLSQLKGNLEE 1322
Score = 57.0 bits (136), Expect = 5e-08
Identities = 96/407 (23%), Positives = 179/407 (43%), Gaps = 60/407 (14%)
Query: 22 AKEQQAEAELRKLRQQFRKMVESRK-SFKFRNQQKIASQYKEI------KTLKTEQDEIT 74
A+ Q EL ++Q +K +E K SFK + +++ Q +I KTL+ +I
Sbjct: 721 AQLQLENKELESEKEQLKKGLELLKASFKKTERLEVSYQGLDIENQRLQKTLENSNKKIQ 780
Query: 75 LLLSLMKSSRNMNRS-EKNYMELRLLLQTKEDYEALIKSLKVLLAELDEKILQME---KK 130
L S ++ N++ +KN EL++ + E E KSL+ ++L++ Q+E K+
Sbjct: 781 QLESELQDLEMENQTLQKNLEELKISSKRLEQLEKENKSLEQETSQLEKDKKQLEKENKR 840
Query: 131 IANQKQIFAKMQEANNPR--KLQKQIHILETRLNLVTVHFDKMLTTNAKLRKEIEDLRFE 188
+ Q +I E NN + L+K+ L + + + + +L KE ++L +
Sbjct: 841 LRQQAEIKDTTLEENNVKIGNLEKENKTLSKEIGI----YKESCVRLKELEKENKEL-VK 895
Query: 189 KAAYD-NVYQQLQHCLLMEK-KTMNLAIEQSSQAYEQRVEAMARMAAMKDRQKKDTSQY- 245
+A D L+ L+ EK KT + + +E + + + D Q D S+Y
Sbjct: 896 RATIDIKTLVTLREDLVSEKLKTQQMNNDLEKLTHELEKIGLNKERLLHDEQSTDDSRYK 955
Query: 246 ------------NLEIRELERLYAHESKLKSFLLVKLNDRNEFEEQAKREEALKAKKHVK 293
+LEI+E E++ A E++L+ R E + K EALK ++ +
Sbjct: 956 LLESKLESTLKKSLEIKE-EKIAALEARLEESTNYNQQLRQELKTVKKNYEALKQRQDEE 1014
Query: 294 K------------NRGESFESYEVAHLRLLKLAESGNLNQLIEDFLAKEEKNFARFTYVT 341
+ N+ E ES E LLK ++D L + E+N A
Sbjct: 1015 RMVQSSPPISGEDNKWER-ESQETTR-ELLK----------VKDRLIEVERNNATLQAEK 1062
Query: 342 E-LNNDMEMMHKRTQRIQDEIILLRSQQKLSHDDNHSVLRQLEDKLR 387
+ L ++ + + +Q +I+ L+ +Q +S + ++ L+ KL+
Sbjct: 1063 QALKTQLKQLETQNNNLQAQILALQ-RQTVSLQEQNTTLQTQNAKLQ 1108
Score = 51.2 bits (121), Expect = 2e-06
Identities = 107/549 (19%), Positives = 205/549 (37%), Gaps = 116/549 (21%)
Query: 21 KAKEQQAEAELRKLRQQFRKMVESRKSFKFRNQQKIASQYKEIKTLKTEQDEITLLLSLM 80
KAK E E R++ +++E + + +Q + E L E ++I+ L
Sbjct: 388 KAKLHDMEMERDMDRKKIEELMEENMTLEMAQKQSM----DESLHLGWELEQISRTSELS 443
Query: 81 KSSRNMNRSEKNYMELRLLLQTKEDYEALIKSLKVLLAELDE------KILQMEKK---- 130
++ + E N + LL+ + + ++L K+++ L +D KIL+MEK+
Sbjct: 444 EAPQKSLGHEVNELTSSRLLKLEMENQSLTKTVEELRTTVDSVEGNASKILKMEKENQRL 503
Query: 131 ----------IANQKQIFAKMQEANNP--------------------------------- 147
I +KQ Q +
Sbjct: 504 SKKVEILENEIVQEKQSLQNCQNLSKDLMKEKAQLEKTIETLRENSERQIKILEQENEHL 563
Query: 148 -------------------RKLQKQIHILETRLNLVTVHFDKMLTTNAKLRKEIEDLRFE 188
+ ++K+ IL + + K+ +++KE+E + +
Sbjct: 564 NQTVSSLRQRSQISAEARVKDIEKENKILHESIKETSSKLSKIEFEKRQIKKELEHYKEK 623
Query: 189 KAAYDNVYQQLQHC----LLMEKKTMNLAI---------------EQSSQAYEQRVEAMA 229
+ + +L H L++KK NL I E+ ++ ++ +++
Sbjct: 624 GERAEELENELHHLEKENELLQKKITNLKITCEKIEALEQENSELERENRKLKKTLDSFK 683
Query: 230 RMAAMKDRQKKDTSQY---NLEI-RELERLYAHESKLKSFLLVKLNDRNEFEEQAKREEA 285
+ + +K+ SQ NLE+ R +E L K+ L +E E+ K E
Sbjct: 684 NLTFQLESLEKENSQLDEENLELRRNVESLKCASMKMAQLQLENKELESEKEQLKKGLEL 743
Query: 286 LKAKKHVKKNRGESFESYEVAHLRLLKLAESGN--LNQLIEDFLAKEEKNFARFTYVTEL 343
LKA + S++ ++ + RL K E+ N + QL + E +N + EL
Sbjct: 744 LKASFKKTERLEVSYQGLDIENQRLQKTLENSNKKIQQLESELQDLEMENQTLQKNLEEL 803
Query: 344 ---NNDMEMMHKRTQRIQDEIILLRSQQKLSHDDNHSVLRQLEDK---LRKTTEEADMYE 397
+ +E + K + ++ E L +K +N + +Q E K L + + E
Sbjct: 804 KISSKRLEQLEKENKSLEQETSQLEKDKKQLEKENKRLRQQAEIKDTTLEENNVKIGNLE 863
Query: 398 SKYGEVSKTLDLLKNS------VEKLFKKINCDAT---KILVQLGETGKVTDINLPQYFA 448
+ +SK + + K S +EK K++ AT K LV L E + Q
Sbjct: 864 KENKTLSKEIGIYKESCVRLKELEKENKELVKRATIDIKTLVTLREDLVSEKLKTQQMNN 923
Query: 449 IIEKKTNDL 457
+EK T++L
Sbjct: 924 DLEKLTHEL 932
Score = 49.7 bits (117), Expect = 7e-06
Identities = 78/409 (19%), Positives = 175/409 (42%), Gaps = 41/409 (10%)
Query: 84 RNMNRSEKNYMELRLLLQT---KEDYEALIKS----LKVLLAELDEK---ILQMEKKIAN 133
+ + +++N +L+ + T +ED E L+K+ LK L+ E DE I+++ ++
Sbjct: 161 QEVTHNQENVFDLQWMEVTDMSQEDIEPLLKNMALHLKRLIDERDEHSETIIELSEERDG 220
Query: 134 QKQIFAKMQEANNPRKLQKQIHILETRLNLVTVHFDKMLTTNAKLRKEIEDLRFEKAAYD 193
+ A +P + E+R +L ++ AK+R+ ++L +
Sbjct: 221 LHFLPHASSSAQSPCG-SPGMKRTESRQHLSV----ELADAKAKIRRLRQELEEKTEQLL 275
Query: 194 NVYQQLQHCLL----MEKKTMNLAIE-QSSQAYEQRVEAMARMAAMKDRQKKDTSQYNLE 248
+ Q+L+ + ++++ MNL + +S++ Y ++A+ A D+ + + S+Y
Sbjct: 276 DCKQELEQMEIELKRLQQENMNLLSDARSARMYRDELDALREKAVRVDKLESEVSRYKER 335
Query: 249 IRELERLYAHESKLKSFLLVKLNDRNEFEEQAKREEALKAKKHVKKNRGESFESYEVAHL 308
+ ++E A +LK V L + E+Q + A K H + ++ ++ +
Sbjct: 336 LHDIEFYKARVEELKEDNQVLLETKTMLEDQLEGTRARSDKLHELEKENLQLKA-KLHDM 394
Query: 309 RLLKLAESGNLNQLIEDFLAKE-------EKNFARFTYVTELNNDMEMMHKRTQRIQDEI 361
+ + + + +L+E+ + E +++ + +++ E+ + + E+
Sbjct: 395 EMERDMDRKKIEELMEENMTLEMAQKQSMDESLHLGWELEQISRTSELSEAPQKSLGHEV 454
Query: 362 ILLRSQQKLSHDDNHSVLRQLEDKLRKTTEEADMYESKYGEVSKTLDLLKNSVEKLFKKI 421
L S + L + + L + ++LR T + + SK ++ K L VE L +I
Sbjct: 455 NELTSSRLLKLEMENQSLTKTVEELRTTVDSVEGNASKILKMEKENQRLSKKVEILENEI 514
Query: 422 --------NC-----DATKILVQLGETGKVTDINLPQYFAIIEKKTNDL 457
NC D K QL +T + N + I+E++ L
Sbjct: 515 VQEKQSLQNCQNLSKDLMKEKAQLEKTIETLRENSERQIKILEQENEHL 563
>gi|34577114 cytomatrix protein p110 [Homo sapiens]
Length = 957
Score = 63.2 bits (152), Expect = 6e-10
Identities = 97/486 (19%), Positives = 215/486 (44%), Gaps = 59/486 (12%)
Query: 1 MSVLKKNRRKDSDTPQEPSEKAKEQQAEAELRKLRQQFRKMVESRKSFKFRNQQKIASQY 60
+ V+ + K++ +E + + Q E K Q +M ++ KIAS
Sbjct: 342 LEVILDQKEKENIHLREELHRRSQLQPEPAKTKALQTVIEMKDT----------KIASLE 391
Query: 61 KEIKTLKTEQDEITLLLSLMKSSRNMNRSEKNYMELRLLLQTKEDYEALIKSLKVLLAEL 120
+ I+ L +DEI +L + N E+ ++ + + + I LK L++
Sbjct: 392 RNIRDL---EDEIQMLKA--NGVLNTEDREEEIKQIEVYKSHSKFMKTKIDQLKQELSKK 446
Query: 121 DEKILQMEKKI---ANQ----KQIFAKMQEANNPRKLQKQIHILETRLNLVTVHFDKMLT 173
+ ++L ++ K+ +NQ KQ ++E+ + +++ IL+T ++ + + ++ +
Sbjct: 447 ESELLALQTKLETLSNQNSDCKQHIEVLKESLTAK--EQRAAILQTEVDALRLRLEEKES 504
Query: 174 TNAKLRKEIEDLRFEKAAYDNVYQQLQHCLLMEKKTMNLAIEQSSQAYEQRVEAMARMAA 233
K K+++DL EK + ++ L ++++ +N+ ++ EQ + ++
Sbjct: 505 FLNKKTKQLQDLTEEKGTLAGEIRDMKDMLEVKERKINVLQKKIENLQEQLRDKDKQLTN 564
Query: 234 MKDRQKK---DTSQYNLEIRELERLYAHESKLKSFLLVKLNDRNEFEEQAKREEALKAKK 290
+KDR K D+S + + LE + + + ++ +L ++ E +++ + EE
Sbjct: 565 LKDRVKSLQTDSSNTDTALATLEEALSEKER----IIERLKEQRERDDRERLEE------ 614
Query: 291 HVKKNRGESFESYEVAHLRLLKLAE-SGNLNQLIEDFLAKEEKNFARFTYVTELNNDMEM 349
++ R E+ + E + +L E +L L E + R ++ ++
Sbjct: 615 -IESFRKENKDLKEKVNALQAELTEKESSLIDLKEHASSLASAGLKR-------DSKLKS 666
Query: 350 MHKRTQRIQDEIILLRSQQKLSH--DDNHSVLRQLEDKLRKTTEEADMYESKYG----EV 403
+ ++ ++E L +Q K +H +D+ + + D++++ +EA Y + G EV
Sbjct: 667 LEIAIEQKKEECSKLEAQLKKAHNIEDDSRMNPEFADQIKQLDKEASYYRDECGKAQAEV 726
Query: 404 SKTLDLLK---NSVEKLFKKI-NCDATKILVQLGETGKVTDINLPQYFAIIEKKTNDLLL 459
+ L++LK N KKI ++ + + KV ++ Q +EKK N LL
Sbjct: 727 DRLLEILKEVENEKNDKDKKIAELESLTLRHMKDQNKKVANLKHNQQ---LEKKKNAQLL 783
Query: 460 LETYRR 465
E RR
Sbjct: 784 EEVRRR 789
Score = 38.1 bits (87), Expect = 0.022
Identities = 60/317 (18%), Positives = 133/317 (41%), Gaps = 50/317 (15%)
Query: 148 RKLQKQIHILETRLNLVTVHFDKMLTT-----NAKLRKEIEDLRFEKAAYDNVYQQLQHC 202
++LQ++ +L L++ + + + +L+KE LR E+AA +V ++
Sbjct: 155 KELQRENDLLRKELDIKDSKLGSSMNSIKTFWSPELKKE-RVLRKEEAARMSVLKEQMRV 213
Query: 203 LLMEKKTMNLAIEQSSQAYEQRVEAMARMAAMKDRQKKDTSQYNLEIRE--LERLYA-HE 259
E + + L I+ E R + ++ + + +E+ E RL A H+
Sbjct: 214 SHEENQHLQLTIQALQD--ELRTQRDLNHLLQQESGNRGAEHFTIELTEENFRRLQAEHD 271
Query: 260 SKLKSFLLVK-----LNDRNEFEEQA--KREEALKAKKHVKKNRGESFESYEVAHLRLLK 312
+ K L++ + R E ++Q R+E++K + +++G +S E + R +
Sbjct: 272 RQAKELFLLRKTLEEMELRIETQKQTLNARDESIKKLLEMLQSKGLPSKSLEDDNERTRR 331
Query: 313 LAESGNLNQLIEDFLAKEE---------------------KNFARFTYVTELNNDMEMMH 351
+AE+ + +E L ++E K A T + + + +
Sbjct: 332 MAEAESQVSHLEVILDQKEKENIHLREELHRRSQLQPEPAKTKALQTVIEMKDTKIASLE 391
Query: 352 KRTQRIQDEIILLRSQQKLSHDDNHSVLRQLEDKLRKTTEEADMYESKYGEVSKTLDLLK 411
+ + ++DEI +L++ L+ +D ++Q+E +Y+S + +D LK
Sbjct: 392 RNIRDLEDEIQMLKANGVLNTEDREEEIKQIE-----------VYKSHSKFMKTKIDQLK 440
Query: 412 NSVEKLFKKINCDATKI 428
+ K ++ TK+
Sbjct: 441 QELSKKESELLALQTKL 457
>gi|14165274 golgi-associated microtubule-binding protein HOOK3
[Homo sapiens]
Length = 718
Score = 62.4 bits (150), Expect = 1e-09
Identities = 81/433 (18%), Positives = 187/433 (43%), Gaps = 53/433 (12%)
Query: 8 RRKDSDTPQEPSEKA--KEQQAEAELRKLRQQFRKMVESRKSFKFRNQQKIASQYKEIKT 65
R SD+ ++P+ A + Q + +L +L+++ ++ ++ ++ R ++ KEI
Sbjct: 226 RLNQSDSIEDPNSPAGRRHLQLQTQLEQLQEETFRLEAAKDDYRIRCEEL----EKEISE 281
Query: 66 LKTEQDEITLLLS-----------LMKSSRNMNRSEKNYMELRLLLQTKEDYEALIKSLK 114
L+ + DE+T L L SS +++ E + L+ D +K L+
Sbjct: 282 LRQQNDELTTLADEAQSLKDEIDVLRHSSDKVSKLEGQVESYKKKLEDLGDLRRQVKLLE 341
Query: 115 VLLAELDEKILQMEKKIANQKQIFAKMQEANNPRKLQKQIHILETRLNLVTVHFDKMLTT 174
++ + M+ ++ ++++ + ++Q+ L+ RL+ + DK+
Sbjct: 342 ------EKNTMYMQNTVSLEEELRKANAARSQLETYKRQVVELQNRLSEESKKADKLDFE 395
Query: 175 NAKLRKEIEDLRFEKAAYDNVYQQLQHCLLMEKKTMNLAIEQ----SSQAYEQRVEAMAR 230
+L+++++ L+ EK L E+ ++ IE+ +Q + + +
Sbjct: 396 YKRLKEKVDSLQKEKDR-----------LRTERDSLKETIEELRCVQAQEGQLTTQGLMP 444
Query: 231 MAAMKDRQKKDTSQYNLEIRELERLYAHESKLKSFLLVKLNDRNEFEEQAKREEALKAKK 290
+ + + EIRE HE+K ++KLN E+ ++L
Sbjct: 445 LGSQESSDSLAAEIVTPEIREKLIRLQHENK-----MLKLNQEGSDNEKIALLQSLLDDA 499
Query: 291 HVKKNRGESFESYEVAHLRLLKL-AESGNLNQLIEDFLAKEEKNFARFTYVTELNNDMEM 349
+++KN E+ + + RLL++ ++ L + ++D +K E + +L +E
Sbjct: 500 NLRKNELET--ENRLVNQRLLEVQSQVEELQKSLQDQGSKAEDS---VLLKKKLEEHLEK 554
Query: 350 MHKRTQRIQDEIILLRSQQKLSHDDNHSVLRQLEDKLRKTTEEADMYESKYGEVSKTLDL 409
+H+ +Q + ++ + ++ + + +L++ LRK EE E +Y K L+
Sbjct: 555 LHEANNELQKKRAIIEDLEPRFNNSSLKI-EELQEALRKKEEEMKQMEERY---KKYLEK 610
Query: 410 LKNSVEKLFKKIN 422
K+ + L K N
Sbjct: 611 AKSVIRTLDPKQN 623
Score = 30.4 bits (67), Expect = 4.5
Identities = 71/358 (19%), Positives = 139/358 (38%), Gaps = 47/358 (13%)
Query: 130 KIANQKQIFAKMQEANNPRKLQKQIHILETRLNLVTVHFDKMLTTNAKLRKEIEDLRFEK 189
KI+N K+I + + N+ Q+ +NL+ H D A+L + ++ +
Sbjct: 72 KISNLKKILKGILDYNHEILGQQINDFTLPDVNLIGEHSDA-----AELGRMLQLILGCA 126
Query: 190 AAYDNVYQQLQHCLLMEKKTMNLAIE--QSSQAYEQRVEAMARMAAMKDRQ-KKDTSQYN 246
+ + +Q ++ME+ ++ + Q + E V A DRQ KK T + N
Sbjct: 127 VNCEQKQEYIQAIMMMEESVQHVVMTAIQELMSKESPVSAGNDAYVDLDRQLKKTTEELN 186
Query: 247 LEIRELERLY--AHESKLKSFLLVKLNDRNEFEEQAKREEALKAKKHVKKNRGESFESYE 304
+ E + HE ++ L + E Q E L ++ + +
Sbjct: 187 EALSAKEEIAQRCHELDMQVAALQEEKSSLLAENQVLMER-LNQSDSIEDPNSPAGRRHL 245
Query: 305 VAHLRLLKLAESG-NLNQLIEDFLAKEEKNFARFTYVTELNNDMEMMHKRTQRIQDEIIL 363
+L +L E L +D+ + E+ + + + N+++ + Q ++DEI
Sbjct: 246 QLQTQLEQLQEETFRLEAAKDDYRIRCEELEKEISELRQQNDELTTLADEAQSLKDEI-- 303
Query: 364 LRSQQKLSHDDNHSVLRQLEDKLRKTTEEADMYESK---YGEVSKTLDLLKN-------- 412
VLR DK+ K + + Y+ K G++ + + LL+
Sbjct: 304 -------------DVLRHSSDKVSKLEGQVESYKKKLEDLGDLRRQVKLLEEKNTMYMQN 350
Query: 413 --SVEKLFKKINCDATKILVQLGETGKVTDINLPQYFAIIEKKTNDLLLLETYRRILE 468
S+E+ +K N +++ ET K + L + KK + L Y+R+ E
Sbjct: 351 TVSLEEELRKANAARSQL-----ETYKRQVVELQNRLSEESKKADKLDF--EYKRLKE 401
>gi|41406064 myosin, heavy polypeptide 10, non-muscle [Homo sapiens]
Length = 1976
Score = 62.0 bits (149), Expect = 1e-09
Identities = 91/408 (22%), Positives = 179/408 (43%), Gaps = 43/408 (10%)
Query: 17 EPSEKAKEQQAEAELRKLRQQFRKMVESRKSFKFRNQQKIASQYKEIKTLKTEQDEITLL 76
+ +E AK + E ++ ++ QF + +++R +N++K K+++ L+ E ++
Sbjct: 1556 QATEDAK-LRLEVNMQAMKAQFERDLQTRDE---QNEEKKRLLIKQVRELEAELEDERKQ 1611
Query: 77 LSLMKSSRNMNRSEKNYMELRLLLQTKEDYEALIKSLKVLLAELDEKILQMEKKIANQKQ 136
+L +S+ + +E ++ K E +IK L+ L A++ + ++E+ A++ +
Sbjct: 1612 RALAVASKKKMEIDLKDLEAQIEAANKARDE-VIKQLRKLQAQMKDYQRELEEARASRDE 1670
Query: 137 IFAKMQEANNPRKLQKQIHILETRLNLVTVHFDKMLTTNAKLRKEIEDLRFEKAAYDNVY 196
IFA+ +E+ +K++ LE + + + L ++ + R+ E R E A
Sbjct: 1671 IFAQSKES------EKKLKSLEAEI----LQLQEELASSERARRHAEQERDELADEITNS 1720
Query: 197 QQLQHCLLMEKKTMNLAIEQSSQAYEQRVEAMARMAAMKDRQKKDTSQYNLEIREL--ER 254
+ LL EK+ + I Q + E E + M + DR +K T Q + EL ER
Sbjct: 1721 ASGKSALLDEKRRLEARIAQLEEELE---EEQSNMELLNDRFRKTTLQVDTLNAELAAER 1777
Query: 255 LYAHESKLKSFLLVKLNDRNEFEEQAKREEALKAKKHVKKNRGESFESYEVAHLRLLKLA 314
A +S N R + E Q K LKAK + +S ++ L A
Sbjct: 1778 SAAQKSD---------NARQQLERQNKE---LKAKLQELEGAVKSKFKATISALE----A 1821
Query: 315 ESGNLNQLIEDFLAKEEKNFARFTYVTELNNDMEMMHKRTQRIQDEIILLRSQQKLSHDD 374
+ G L + +E AKE + TE M +R + Q K +
Sbjct: 1822 KIGQLEEQLEQE-AKERAAANKLVRRTEKKLKEIFMQVEDERRHAD------QYKEQMEK 1874
Query: 375 NHSVLRQLEDKLRKTTEEADMYESKYGEVSKTLDLLKNSVEKLFKKIN 422
++ ++QL+ +L + EEA + ++ + LD + E L ++++
Sbjct: 1875 ANARMKQLKRQLEEAEEEATRANASRRKLQRELDDATEANEGLSREVS 1922
Score = 58.5 bits (140), Expect = 2e-08
Identities = 116/496 (23%), Positives = 202/496 (40%), Gaps = 65/496 (13%)
Query: 17 EPSEKAKEQQAEAE-LRKLRQQFRKMVESRKSFKF-RNQQKIASQYKEIKTLKTEQDEIT 74
E +EKA + Q E + + L ++ K K KF ++ + SQ ++ + L E+
Sbjct: 1277 ELAEKASKLQNELDNVSTLLEEAEK-----KGIKFAKDAASLESQLQDTQELLQEETRQK 1331
Query: 75 LLLSLMKSSRNMNRSEKNYMELRLLLQTKEDYEALIKSLKVLLAELDEKILQMEKKIANQ 134
L LS S EKN ++ + +E+ E K+L+ + L ++ +KK+ +
Sbjct: 1332 LNLS---SRIRQLEEEKNSLQ-----EQQEEEEEARKNLEKQVLALQSQLADTKKKVDDD 1383
Query: 135 KQIFAKMQEANNPRKLQKQIHILETRLNLVTVHFDKMLTTNAKLRKEIEDLRFEKAAYDN 194
++EA +KL K L RL + +DK+ T +L++E++DL + D+
Sbjct: 1384 LGTIESLEEAK--KKLLKDAEALSQRLEEKALAYDKLEKTKNRLQQELDDLTVD---LDH 1438
Query: 195 VYQQLQHCLLMEKKTMNLAIEQSSQAYEQRVEAMARMAAMKDRQKKDTSQYNLEIRELER 254
Q + +KK L E+ S AR A +DR + + + + L R
Sbjct: 1439 QRQVASNLEKKQKKFDQLLAEEKS--------ISARYAEERDRAEAEAREKETKALSLAR 1490
Query: 255 LYAHESKLKSFLLVKLNDRNEFEEQAKR-----EEALKAKKHVKKNRGESFES-----YE 304
A E L++ + EFE Q K+ E+ + +K V KN E +S +
Sbjct: 1491 --ALEEALEA--------KEEFERQNKQLRADMEDLMSSKDDVGKNVHELEKSKRALEQQ 1540
Query: 305 VAHLRLLKLAESGNLNQLIEDFLAKEEKN-------FARFTYVTELNND--MEMMHKRTQ 355
V +R +L E + Q ED + E N F R + N+ ++ K+ +
Sbjct: 1541 VEEMR-TQLEELEDELQATEDAKLRLEVNMQAMKAQFERDLQTRDEQNEEKKRLLIKQVR 1599
Query: 356 RIQDEIILLRSQQKLSHDDNHSVLRQLEDKLRKTTEEADMYESKYGEVSKTLDLLKNSVE 415
++ E+ R Q+ L+ + L+D L E A+ + + + L +
Sbjct: 1600 ELEAELEDERKQRALAVASKKKMEIDLKD-LEAQIEAANKARDEVIKQLRKLQAQMKDYQ 1658
Query: 416 KLFKKINCDATKILVQLGETGKVTDINLPQYFAIIEKKTNDLLLLETYRRILEVEGAEAE 475
+ ++ +I Q E+ K L A I + +L E RR E E E
Sbjct: 1659 RELEEARASRDEIFAQSKESEK----KLKSLEAEILQLQEELASSERARRHAEQE--RDE 1712
Query: 476 IPPPFINPFWGGSALL 491
+ N G SALL
Sbjct: 1713 LADEITNSASGKSALL 1728
Score = 52.4 bits (124), Expect = 1e-06
Identities = 100/448 (22%), Positives = 208/448 (46%), Gaps = 39/448 (8%)
Query: 9 RKDSDTPQEPSEKAKEQQAEAELRKLRQQFRKMVESRKSFKFRNQQKIASQYKEIKTLKT 68
R D +T + + ++ +A++ +L++ F ES K+ + + +++ +E++ LKT
Sbjct: 1098 RGDDETLHKNNALKVVRELQAQIAELQEDF----ESEKASRNKAEKQKRDLSEELEALKT 1153
Query: 69 EQDEITLLLSLMKSSRNMNRSEKNYMELRLLLQTKEDYEALIKSLK----VLLAELDEKI 124
E ++ + + R E ++ L +TK ++EA I+ ++ L EL E++
Sbjct: 1154 ELEDTLDTTAAQQELRTKREQEVAELKKALEEETK-NHEAQIQDMRQRHATALEELSEQL 1212
Query: 125 LQMEKKIANQKQIFAKMQEANNPRKLQKQIHILETRLNLVTVHFDKMLTT-----NAKLR 179
Q ++ AN ++ ++ N ++L ++ +L+ ++ + H K L +AK+
Sbjct: 1213 EQAKRFKANLEKNKQGLETDN--KELACEVKVLQ-QVKAESEHKRKKLDAQVQELHAKV- 1268
Query: 180 KEIEDLRFEKAAYDNVYQ-QLQH--CLLMEKKTMNLAIEQSSQAYEQRVEAMARMAAMKD 236
E + LR E A + Q +L + LL E + + + + + E +++ + +
Sbjct: 1269 SEGDRLRVELAEKASKLQNELDNVSTLLEEAEKKGIKFAKDAASLESQLQDTQELLQEET 1328
Query: 237 RQKKDTSQYNLEIRELERLYAHESKLKSFLLVKLNDRNEFEEQ--AKREEALKAKKHVKK 294
RQK + S IR+LE ++ L+ + R E+Q A + + KK V
Sbjct: 1329 RQKLNLSS---RIRQLEE---EKNSLQEQQEEEEEARKNLEKQVLALQSQLADTKKKVDD 1382
Query: 295 NRGESFESYEVAHLRLLKLAESGNLNQLIED-FLAKEEKNFARFTYVTELNN-DMEMMHK 352
+ G + ES E A +LLK AE+ L+Q +E+ LA ++ + EL++ +++ H+
Sbjct: 1383 DLG-TIESLEEAKKKLLKDAEA--LSQRLEEKALAYDKLEKTKNRLQQELDDLTVDLDHQ 1439
Query: 353 RTQRIQDEIILLRSQQKLSHDDNHSVLRQLEDKLRKTTEEADMYESKYGEVSKTLD---L 409
R E + Q L+ + + S R E++ R E + E+K +++ L+
Sbjct: 1440 RQVASNLEKKQKKFDQLLAEEKSISA-RYAEERDRAEAEAREK-ETKALSLARALEEALE 1497
Query: 410 LKNSVEKLFKKINCDATKILVQLGETGK 437
K E+ K++ D ++ + GK
Sbjct: 1498 AKEEFERQNKQLRADMEDLMSSKDDVGK 1525
Score = 39.3 bits (90), Expect = 0.010
Identities = 51/198 (25%), Positives = 88/198 (44%), Gaps = 16/198 (8%)
Query: 230 RMAAMKDRQKKDTSQYNLEIRELERLYAHESKLKSFLLVKLNDRNEFEEQAKREEALKAK 289
+++A+K Q+ + L + R++ +K+K L V R E E QAK EE LK K
Sbjct: 812 QLSALKVLQRNCAAYLKLRHWQWWRVF---TKVKPLLQVT---RQEEELQAKDEELLKVK 865
Query: 290 KHVKKNRGESFESYEVAHLRLLK----LAESGNLNQLIEDFLAKEEKNFARFTYVTELNN 345
+ K GE E E H +LL+ LAE L E F EE EL
Sbjct: 866 EKQTKVEGE-LEEMERKHQQLLEEKNILAE--QLQAETELFAEAEEMRARLAAKKQELEE 922
Query: 346 DMEMMHKRTQRIQDEIILLRSQQKLSHDDNHSVLRQLEDK---LRKTTEEADMYESKYGE 402
+ + R + ++ +L++++K + QL+++ +K E E+K +
Sbjct: 923 ILHDLESRVEEEEERNQILQNEKKKMQAHIQDLEEQLDEEEGARQKLQLEKVTAEAKIKK 982
Query: 403 VSKTLDLLKNSVEKLFKK 420
+ + + LL++ K K+
Sbjct: 983 MEEEILLLEDQNSKFIKE 1000
>gi|4885399 structural maintenance of chromosomes 3 [Homo sapiens]
Length = 1217
Score = 61.2 bits (147), Expect = 2e-09
Identities = 100/450 (22%), Positives = 185/450 (41%), Gaps = 86/450 (19%)
Query: 9 RKDSDTPQEPSEKAKEQQAEAELRKLRQQFRKMVESRKSFKFRNQ-QKIASQYKEIKT-- 65
RK Q+ KA+E+ E E KL + R+ +E + N+ ++ +Q ++I+T
Sbjct: 672 RKSRLELQKDVRKAEEELGELEA-KLNENLRRNIE-----RINNEIDQLMNQMQQIETQQ 725
Query: 66 --LKTEQDEITLLLSLMKSSRNMNRSEKNYMELRLLLQTKE-DYEALIKSLKVLLAELDE 122
K +D I + ++K R +SEK +M + LQ+ E A+ + + L AEL
Sbjct: 726 RKFKASRDSILSEMKMLKEKRQ--QSEKTFMPKQRSLQSLEASLHAMESTRESLKAELGT 783
Query: 123 KILQMEKKIANQKQIFAKMQEANNPRKLQKQIHILETRLNLVTVHFDKMLTTNAKLRKEI 182
+L + + +QK++ A E ++ +Q+ L R+ L + N LRK +
Sbjct: 784 DLLS-QLSLEDQKRVDALNDEIRQLQQENRQL--LNERIKLEGIITRVETYLNENLRKRL 840
Query: 183 EDLRFEKAAYDNVYQQLQHCLLMEKKTMNLAIEQSSQAYEQRV-EAMARM---------- 231
D V Q+L E T+ A +A +RV + MAR
Sbjct: 841 ----------DQVEQELNELRETEGGTVLTATTSELEAINKRVKDTMARSEDLDNSIDKT 890
Query: 232 -AAMKDRQKKDTSQYNLEIRELERLYAHESKLKSFLLVKLNDRNEFEEQAKREEALKAKK 290
A +K+ QK N+E ++ + H++K L K+ +R + K+EE +K +
Sbjct: 891 EAGIKELQKSMERWKNMEKEHMDAIN-HDTKE----LEKMTNRQGMLLK-KKEECMKKIR 944
Query: 291 HVKKNRGESFESYEVAHLRLLKLAESGNLNQLIEDFLAKEEKNFARFTYVTELNNDMEMM 350
+ E+FE Y+ L+ L F + + N +++
Sbjct: 945 ELGSLPQEAFEKYQTLSLKQL-------------------------FRKLEQCNTELKKY 979
Query: 351 HKRTQRIQDEIILLRSQQKLSHDDNHSVLRQLEDKLRKTTEEADMYESKYGEVSKTLDLL 410
++ D+ + Q ++KL K EE D E+ L+L
Sbjct: 980 SHVNKKALDQFVNFSEQ---------------KEKLIKRQEELDRGYKSIMELMNVLELR 1024
Query: 411 K-NSVEKLFKKINCDATKILVQLGETGKVT 439
K +++ FK+++ + +++ +L GK T
Sbjct: 1025 KYEAIQLTFKQVSKNFSEVFQKLVPGGKAT 1054
Score = 37.7 bits (86), Expect = 0.028
Identities = 69/353 (19%), Positives = 146/353 (41%), Gaps = 26/353 (7%)
Query: 48 FKFRNQQKIASQYKEIKTLKTEQDEITLLLSLMKSSRNMNRSEKNYMELRLLLQTKEDYE 107
F N I Q K I + T D L L L + + E+ + L+ +T+ E
Sbjct: 130 FSRSNPYYIVKQGK-INQMATAPDSQRLKL-LREVAGTRVYDERKEESISLMKETEGKRE 187
Query: 108 ALIKSLKVLLAELDEKILQMEKKIANQKQIFAKMQEANNPRKLQKQIHILETRLNLVTVH 167
+ + LK + L L+ EK+ Q Q + KM+ A ++++ +L+ ++
Sbjct: 188 KINELLKYIEERLHT--LEEEKEELAQYQKWDKMRRALEYTIYNQELNETRAKLDELSAK 245
Query: 168 FDKMLTTNAKLRKEIEDLRFEKAAYDNVYQQLQHCLLMEKKTMNLAIEQSSQAYEQRVEA 227
+ + +LR +D R + + ++L+ + K+ + + +QR +
Sbjct: 246 RETSGEKSRQLRDAQQDARDKMEDIERQVRELKTKISAMKEEKEQLSAERQEQIKQRTKL 305
Query: 228 MARMAAMKDRQKKDTSQYNLEIRELERLYAH-ESKLKSFLLV--KLNDRNEFEEQ--AKR 282
+ ++D ++ Q ++E ++L E K K K N E EE+ A+
Sbjct: 306 ELKAKDLQDELAGNSEQRKRLLKERQKLLEKIEEKQKELAETEPKFNSVKEKEERGIARL 365
Query: 283 EEALKAKK--HVKKNRGESFESYE------VAHLRLLKLAESGNLNQL------IEDFLA 328
+A + + + K+ RG F S E L+ L A + Q+ +ED A
Sbjct: 366 AQATQERTDLYAKQGRGSQFTSKEERDKWIKKELKSLDQAINDKKRQIAAIHKDLEDTEA 425
Query: 329 KEEKNFARFTYVTELNNDMEMMHKRTQRIQDEIILLRSQQKLSHDDNHSVLRQ 381
+EKN ++ +L+ D+ + R + + + +++++ + + + R+
Sbjct: 426 NKEKNLEQY---NKLDQDLNEVKARVEELDRKYYEVKNKKDELQSERNYLWRE 475
>gi|239756241 PREDICTED: golgi autoantigen, golgin subfamily a-like
[Homo sapiens]
Length = 899
Score = 60.8 bits (146), Expect = 3e-09
Identities = 82/424 (19%), Positives = 191/424 (45%), Gaps = 48/424 (11%)
Query: 5 KKNRRKDSDTPQEPSEKAKEQQAEAELRKLRQQFRKMVESRKSFKFRNQQK-IASQYKEI 63
+K RK + E+ +EQ+ K+R+Q KM K + R Q+K + Q KE+
Sbjct: 285 EKKIRKQEEKMWRQEERLREQEG-----KMREQEEKMWRQEK--RLREQEKELREQEKEL 337
Query: 64 ---KTLKTEQDEITLLLSLMKSSRNMNRSEKNYM---ELRLLLQTKE--DYEALIKSLKV 115
K L+ +++++ M R ++ M E RL Q K+ + E ++ +
Sbjct: 338 REQKELREQEEQMQEQEEKMWEQEEKMREQEEKMWRQEERLWEQEKQMREQEQKMRDQEE 397
Query: 116 LLAELDEKILQMEKKIANQKQIFAKMQEANNPRKLQKQIHILETRLNLVTVHFDKMLTTN 175
+ E DE++ + E+++ Q++++ ++++ +K+Q+Q + + +++
Sbjct: 398 RMWEQDERLREKEERMREQEKMWEQVEKMREEKKMQEQEKKTRDQEEKMQEE-ERIRERE 456
Query: 176 AKLRKEIEDLRFEKAAYDNVYQQLQHCLLMEKKTMNLAIEQSSQAYEQRVEAMARMAAMK 235
K+R+E E +R ++ + + +Q ++ E+K E Q ++ E + M+
Sbjct: 457 KKMREEEETMREQE---EKMQKQEENMWEQEEK------EWQQQRLPEQKEKLWEQEKMQ 507
Query: 236 DRQKKDTSQYNLEIRELERLYAHESKLKSFLLVKLNDRNEFEEQAKREEALKAKKHVKKN 295
++++K Q +IR+ E ++ E K+ + ++ RE+ + + +K
Sbjct: 508 EQEEKIWEQEE-KIRDQEEMWGQEKKM-------------WRQEKMREQEDQMWEQEEKM 553
Query: 296 RGESFESYEVAHLRLLKLAESGNLNQLIEDFLAKEEKNFARFTYVTELNNDMEMMHKRTQ 355
R + + ++ K E E+ + +EE+ R ++ + EMM ++ +
Sbjct: 554 RDQEQKMWDQEERMEKKTQEQEKKTWDQEEKMREEERMRER---EKKMREEEEMMREQEE 610
Query: 356 RIQDEIILLRSQQKLSHDDNHSVLRQLEDKLRKTTEEADMYESKYGEVSKTLDLLKNSVE 415
++Q++ ++ Q++ + + Q E+K+ + E+ E K E + L E
Sbjct: 611 KMQEQEEKMQEQEEKMWEQEEKMQEQ-EEKMWEQEEKMWEQEEKMWEQQR----LPEQKE 665
Query: 416 KLFK 419
KL++
Sbjct: 666 KLWE 669
Score = 50.4 bits (119), Expect = 4e-06
Identities = 53/288 (18%), Positives = 127/288 (44%), Gaps = 8/288 (2%)
Query: 16 QEPSEKAKEQQAEAELRKLRQQFRKMVESRKSFKFRNQQKIASQYKEIKTLKTEQDEITL 75
QE + ++Q E E K+R Q +KM + + + + Q++ + + + ++ E+
Sbjct: 536 QEKMREQEDQMWEQE-EKMRDQEQKMWDQEERMEKKTQEQEKKTWDQEEKMREEERMRER 594
Query: 76 LLSLMKSSRNMNRSEKNYMELRLLLQTKED----YEALIKSLKVLLAELDEKILQMEKKI 131
+ + M E+ E +Q +E+ E ++ + + E +EK+ + E+K+
Sbjct: 595 EKKMREEEEMMREQEEKMQEQEEKMQEQEEKMWEQEEKMQEQEEKMWEQEEKMWEQEEKM 654
Query: 132 ANQKQIFAKMQEANNPRKLQKQIHILETRLNL-VTVHFDKMLTTNAKLRKEIEDLRFEKA 190
Q+++ + ++ K+Q+Q + E + +K K + E +R E++
Sbjct: 655 WEQQRLPEQKEKLWEHEKMQEQEKMQEQEEKIWEQEKMEKKTQEQEKKTWDQEKMREEES 714
Query: 191 AYDNVYQQLQHCLLMEKKTMNLAIEQSSQAYEQRVEAMARMAAMKDRQKKDTSQYNLEIR 250
+ + + +M ++ + EQ + EQ E + M ++++K Q L
Sbjct: 715 MREREKKMREEEEMMREQEEKMQ-EQEEKMQEQEEEMWEQEEKMWEQEEKMWEQQRLP-E 772
Query: 251 ELERLYAHESKLKSFLLVKLNDRNEFEEQAKREEALKAKKHVKKNRGE 298
+ E+L+ HE + + + ++ +E+ R + K + +K RG+
Sbjct: 773 QKEKLWEHEKMQEQEKIWEQEEKMRDQEEKMRGQEEKMRGQEEKMRGQ 820
Score = 46.6 bits (109), Expect = 6e-05
Identities = 53/250 (21%), Positives = 111/250 (44%), Gaps = 11/250 (4%)
Query: 17 EPSEKAKEQQAEAELRKLRQQFRKMVESRKSFKFRNQQKIASQYKEIKTLKTEQDEITLL 76
E EK EQQ E ++ + KM E K + ++KI Q K K + EQ++ T
Sbjct: 649 EQEEKMWEQQRLPEQKEKLWEHEKMQEQEKMQE--QEEKIWEQEKMEKKTQ-EQEKKTWD 705
Query: 77 LSLMKSSRNMNRSEKNYMELRLLLQTKED----YEALIKSLKVLLAELDEKILQMEKKIA 132
M+ +M EK E +++ +E+ E ++ + + E +EK+ + E+K+
Sbjct: 706 QEKMREEESMREREKKMREEEEMMREQEEKMQEQEEKMQEQEEEMWEQEEKMWEQEEKMW 765
Query: 133 NQKQIFAKMQEANNPRKLQKQIHILETRLNLVTVHFDKMLTTNAKLRKEIEDLRFEKAAY 192
Q+++ + ++ K+Q+Q I E + +KM K+R + E +R ++
Sbjct: 766 EQQRLPEQKEKLWEHEKMQEQEKIWEQEEKMRDQE-EKMRGQEEKMRGQEEKMRGQE--- 821
Query: 193 DNVYQQLQHCLLMEKKTMNLAIEQSSQAYEQRVEAMARMAAMKDRQKKDTSQYNLEIREL 252
+ ++ Q + E+K + Q + + + M+++++K Q +
Sbjct: 822 EKMWGQEEKMWGQEEKMWGQEEKMWGQEEKMEEKMQGQEEKMREQEEKMRGQEEKMREQE 881
Query: 253 ERLYAHESKL 262
E++ E K+
Sbjct: 882 EKMRGQEEKI 891
>gi|55770834 centromere protein F [Homo sapiens]
Length = 3114
Score = 60.8 bits (146), Expect = 3e-09
Identities = 93/462 (20%), Positives = 199/462 (43%), Gaps = 61/462 (13%)
Query: 19 SEKAKEQQAEAELRKLRQQFRKMVESRKSFKFRNQQKIASQYKEIKT-LKTEQDEITLLL 77
+E KEQ+ +EL + F +++ ++ K + ++K ++ + ++T LK + + L
Sbjct: 2399 NELQKEQERISELEIINSSFENILQEKEQEKVQMKEKSSTAMEMLQTQLKELNERVAALH 2458
Query: 78 SLMKSSRNMNRSEKNYME---------LRLLLQTKEDYEALIKSLKVLLAEL-------- 120
+ ++ + ++ + +E L+ L + K +Y L S+ L+ E+
Sbjct: 2459 NDQEACKAKEQNLSSQVECLELEKAQLLQGLDEAKNNYIVLQSSVNGLIQEVEDGKQKLE 2518
Query: 121 --DEKILQMEKKIANQKQIFAKMQEANNPRKLQKQIHILETRLNLVTVHFDKML----TT 174
DE+I +++ +I +Q+Q+ +K+ + +L K+ ++ L +TV ++ + +
Sbjct: 2519 KKDEEISRLKNQIQDQEQLVSKLSQVEGEHQLWKEQNL---ELRNLTVELEQKIQVLQSK 2575
Query: 175 NAKLRKEIEDLRFEKAAYDNVYQQLQHCLLMEKKTMNLAIEQSSQAYEQRVEAMARMAAM 234
NA L+ +E L +++Y N+ +L+ + ++ ++V M
Sbjct: 2576 NASLQDTLEVL---QSSYKNLENELE------------LTKMDKMSFVEKVNKMTAKETE 2620
Query: 235 KDRQKKDTSQYNLEIRELERLYAHESKLKSFLLVKLNDRNEFEEQAKREEALKAKKHVKK 294
R+ + +Q E++ E L +++L L + L + ++Q K E +KK
Sbjct: 2621 LQREMHEMAQKTAELQ--EELSGEKNRLAGELQLLLEEIKSSKDQLK--ELTLENSELKK 2676
Query: 295 NRGESFESYEVAHLRLLKLAESGNLNQLIEDF---LAKEEKNFARFTYVTELNNDMEMMH 351
S + H ++ + G + + I ++ L + EK T ++E+
Sbjct: 2677 -------SLDCMHKD--QVEKEGKVREEIAEYQLRLHEAEKKHQALLLDTNKQYEVEIQT 2727
Query: 352 KRTQRIQDEIILLRSQQKLSHDDNHSVLRQLEDKLRKTTEEADMYESKYGEVSKTLDLLK 411
R + E L S QKL D S +L + L+ TT+ + + + K ++ LK
Sbjct: 2728 YREKLTSKEECL--SSQKLEIDLLKSSKEELNNSLKATTQILEELKKTKMDNLKYVNQLK 2785
Query: 412 NSVEKLFKKINCDATKILVQLGETGKVTDINLPQYFAIIEKK 453
E+ K+ K QL E ++ L Q A EK+
Sbjct: 2786 KENERAQGKMKL-LIKSCKQLEEEKEILQKELSQLQAAQEKQ 2826
Score = 53.5 bits (127), Expect = 5e-07
Identities = 83/410 (20%), Positives = 168/410 (40%), Gaps = 66/410 (16%)
Query: 17 EPSEKAKEQQAEAELRKLRQQFRKMVESRKSFKFRNQQKIASQYKEIKTLKTEQDEITLL 76
E K KE++ + EL + ++ F+ + + K R Q++ L+ E D++T +
Sbjct: 386 EQKIKEKEKEFQEELSRQQRSFQTLDQECIQMKARLTQELQQAKNMHNVLQAELDKLTSV 445
Query: 77 LSLMKSS-----RNMNRSEKNYM-------ELRLLLQTKEDYEALIKSLKVLLAELD--- 121
++++ + + R+E+ + ELR ++ + L+KS A
Sbjct: 446 KQQLENNLEEFKQKLCRAEQAFQASQIKENELRRSMEEMKKENNLLKSHSEQKAREVCHL 505
Query: 122 EKILQMEKKIANQKQIFAKMQEANNP------RKLQKQIHILETRLNLVTVHFDKMLTTN 175
E L+ K+ NQ Q FA+ +A N R LQ++I+ E L L
Sbjct: 506 EAELKNIKQCLNQSQNFAEEMKAKNTSQETMLRDLQEKINQQENSLTL------------ 553
Query: 176 AKLRKEIEDLRFEKAAYDNVYQQLQHCLLM----------EKKTMNLAIEQSSQAYEQRV 225
KL+ + DL ++ ++ ++ +H + E K + A+E + YE+
Sbjct: 554 EKLKLAVADLEKQRDCSQDLLKKREHHIEQLNDKLSKTEKESKALLSALELKKKEYEELK 613
Query: 226 EAMARMAAMKDRQKKDTSQYNLEIRELERLYAHESKLKSFLLVKLNDRNEFEEQAKREE- 284
E + K +K +Q E L+ H L++ L + +E+ E+ + E
Sbjct: 614 EEKTLFSCWKSENEKLLTQMESEKENLQSKINH---LETCLKTQQIKSHEYNERVRTLEM 670
Query: 285 -------ALKAKKHVKKNRGESFESYEVAHLRLLKLAESGNLNQLIEDFLAKEEKNFARF 337
++ +V ++ E+ ++A++ L + AE + KE +N
Sbjct: 671 DRENLSVEIRNLHNVLDSKSVEVETQKLAYMELQQKAEFSDQKH------QKEIENMCLK 724
Query: 338 TYVTELNNDMEMMHKRTQRIQDEIILLRSQQKLSHDDNHSVLRQLEDKLR 387
T ++L +E + + Q + +EI+ + + D H+ L D L+
Sbjct: 725 T--SQLTGQVEDLEHKLQLLSNEIM----DKDRCYQDLHAEYESLRDLLK 768
Score = 45.1 bits (105), Expect = 2e-04
Identities = 94/487 (19%), Positives = 190/487 (39%), Gaps = 96/487 (19%)
Query: 19 SEKAKEQQAEAELRKLRQQFRKMVESRKSFKFRNQQKIA----SQYKEIKTLKTEQDEIT 74
+EK KE++ E + K + + +E NQ+ + + E++TLKT+ +E+
Sbjct: 2139 AEKLKERERENDSLKDKVE---NLERELQMSEENQELVILDAENSKAEVETLKTQIEEMA 2195
Query: 75 LLLSLMKSSRNMNRSEKNYMELRLLLQTKE----DYEALIKSLKVLLAELDEKILQMEKK 130
L + + RSEK L +Q K+ + + L+ S K LL E ++ +Q++++
Sbjct: 2196 RSLKVFELDLVTLRSEKE--NLTKQIQEKQGQLSELDKLLSSFKSLLEEKEQAEIQIKEE 2253
Query: 131 IANQKQIFAKMQEANNPRKLQKQIHIL---ETRLNLVTVHFDKMLTTNAKLRKEIEDLRF 187
++ N ++L + + L + + D + +LR IE LR
Sbjct: 2254 SKTAVEML-----QNQLKELNEAVAALCGDQEIMKATEQSLDPPIEEEHQLRNSIEKLRA 2308
Query: 188 EKAAYDN----VYQQLQ----HCLLMEKKTMNL--------------AIEQSS-----QA 220
A + V QQL+ H L++ + NL A+E + +
Sbjct: 2309 RLEADEKKQLCVLQQLKESEHHADLLKGRVENLERELEIARTNQEHAALEAENSKGEVET 2368
Query: 221 YEQRVEAMAR--------MAAMKDRQKKDTSQYNLEIRELERLYAHESKLKSFLLVKLND 272
+ ++E M + + ++ ++ T++ E + L S ++ L K +
Sbjct: 2369 LKAKIEGMTQSLRGLELDVVTIRSEKENLTNELQKEQERISELEIINSSFENILQEKEQE 2428
Query: 273 RNEFEEQAKR----------------------EEALKAKKHVKKNRGESFESYEVAHLRL 310
+ + +E++ +EA KAK ++N E E+ +L
Sbjct: 2429 KVQMKEKSSTAMEMLQTQLKELNERVAALHNDQEACKAK---EQNLSSQVECLELEKAQL 2485
Query: 311 LK-LAESGN-----------LNQLIEDFLAKEEKNFARFTYVTELNNDMEMMHKRTQRIQ 358
L+ L E+ N L Q +ED K EK + + D E + + +++
Sbjct: 2486 LQGLDEAKNNYIVLQSSVNGLIQEVEDGKQKLEKKDEEISRLKNQIQDQEQLVSKLSQVE 2545
Query: 359 DEIILLRSQQKLSHD---DNHSVLRQLEDKLRKTTEEADMYESKYGEVSKTLDLLKNSVE 415
E L + Q + + ++ L+ K + ++ +S Y + L+L K
Sbjct: 2546 GEHQLWKEQNLELRNLTVELEQKIQVLQSKNASLQDTLEVLQSSYKNLENELELTKMDKM 2605
Query: 416 KLFKKIN 422
+K+N
Sbjct: 2606 SFVEKVN 2612
Score = 44.7 bits (104), Expect = 2e-04
Identities = 85/425 (20%), Positives = 162/425 (38%), Gaps = 82/425 (19%)
Query: 2 SVLKKNRRKDSDTPQEPSE----KAKEQQAEAELRKLRQQFRKMVESRKSFKFRNQQKIA 57
S++ N+R+ + QE A Q + L + + F ++ R+ ++ +++
Sbjct: 960 SIISLNKREIEELTQENGTLKEINASLNQEKMNLIQKSESFANYIDERE----KSISELS 1015
Query: 58 SQYKEIKTL-------------------KTEQDEITLLLSLMKSSRNMNRSEKNYMELRL 98
QYK+ K + K Q++ + L L+ ++ + KN +E
Sbjct: 1016 DQYKQEKLILLQRCEETGNAYEDLSQKYKAAQEKNSKLECLLNECTSLCENRKNELEQLK 1075
Query: 99 LLQTKEDYEALIKSLKVLLAELDEKILQMEKKIANQKQIFAKMQEANNPRK----LQKQI 154
KE E L K + AE + L +E + Q NN + L+++I
Sbjct: 1076 EAFAKEHQEFLTK---LAFAEERNQNLMLELETVQQALRSEMTDNQNNSKSEAGGLKQEI 1132
Query: 155 HILETRLNLVTVHFDKMLTTNAKLRKEIEDLRFEKAAYDNVYQQLQHCLLMEKKTMNLAI 214
L+ N K++KE+ DL E V + C +E + + ++
Sbjct: 1133 MTLKEEQN--------------KMQKEVNDLLQENEQLMKVMKTKHECQNLESEPIRNSV 1178
Query: 215 EQSSQAYEQRVEAMARMAAMKDRQKKDTS--QYNLEIRELERLYAH-ESKLKSFLLVK-- 269
++ Q D + K+ S YN ++ +LE + + E KL+ K
Sbjct: 1179 KERESERNQ-----CNFKPQMDLEVKEISLDSYNAQLVQLEAMLRNKELKLQESEKEKEC 1233
Query: 270 -----------LNDRNEFEEQAKREEALK------AKKHVKKNRGESFESYEVAHLRLLK 312
L N + Q++ LK +K++ S + AHL+
Sbjct: 1234 LQHELQTIRGDLETSNLQDMQSQEISGLKDCEIDAEEKYISGPHELSTSQNDNAHLQCSL 1293
Query: 313 LAESGNLNQL--IEDFLAKEEKNFARFTYVTELNNDMEMMHKRTQRIQDEIILLRSQQKL 370
LN+L I + L E ++ VTELN+ T+++ +E+ L ++ K+
Sbjct: 1294 QTTMNKLNELEKICEILQAE-----KYELVTELNDSRSECITATRKMAEEVGKLLNEVKI 1348
Query: 371 SHDDN 375
+DD+
Sbjct: 1349 LNDDS 1353
Score = 43.5 bits (101), Expect = 5e-04
Identities = 48/246 (19%), Positives = 110/246 (44%), Gaps = 12/246 (4%)
Query: 22 AKEQQAEAELRKLRQQFRKMVESRKSFKFRNQQKIASQYKEIKTLKTEQDEITLLLSLMK 81
AKE + + E+ ++ Q+ ++ E K R ++ +EIK+ K + E+TL S +K
Sbjct: 2616 AKETELQREMHEMAQKTAELQEELSGEKNRLAGELQLLLEEIKSSKDQLKELTLENSELK 2675
Query: 82 SSRNMNRSEKNYMELRLLLQTKEDYEALIKSLKVLLAELDEKILQMEKKIANQKQIFAKM 141
S + ++ E ++ + E L ++ K A L + Q E +I ++
Sbjct: 2676 KSLDCMHKDQVEKEGKVREEIAEYQLRLHEAEKKHQALLLDTNKQYEVEIQTYREKLTSK 2735
Query: 142 QEANNPRKLQKQIHILETRLNLVTVHFDKMLTTNAKLRKEIEDLRFEKAAYDNVYQQLQH 201
+E + +KL +I +L++ + L ++ +E++ + + Y N ++
Sbjct: 2736 EECLSSQKL--EIDLLKSSKE----ELNNSLKATTQILEELKKTKMDNLKYVNQLKKENE 2789
Query: 202 CLLMEKKTMNLAIEQSSQAYEQRVEAMARMAAMKDRQKKDT------SQYNLEIRELERL 255
+ K + + +Q + E + ++++ A +++QK T + EI+EL+
Sbjct: 2790 RAQGKMKLLIKSCKQLEEEKEILQKELSQLQAAQEKQKTGTVMDTKVDELTTEIKELKET 2849
Query: 256 YAHESK 261
++K
Sbjct: 2850 LEEKTK 2855
Score = 43.1 bits (100), Expect = 7e-04
Identities = 95/469 (20%), Positives = 181/469 (38%), Gaps = 94/469 (20%)
Query: 19 SEKAKEQQAEAELRKLR-QQFRKMVESRKSFKFRNQQKIASQYKEIKTLKTEQDEITLLL 77
SEK KE+ E E + ++ E+ K Q ++S E+ KT E L
Sbjct: 1981 SEKMKEKTQELESHQSECLHCIQVAEAEVKEKTELLQTLSSDVSELLKDKTHLQE--KLQ 2038
Query: 78 SLMKSSRNMNRSEKNYMELR-LLLQTKEDYEALIK---SLKVLLAELDEKILQMEKKIAN 133
SL K S+ ++ ++ EL + Q ++ E L+K SL+ L+E D + L + K +
Sbjct: 2039 SLEKDSQALSLTK---CELENQIAQLNKEKELLVKESESLQARLSESDYEKLNVSKAL-- 2093
Query: 134 QKQIFAKMQEANNPRKLQKQIHILETRLNLVTVHFDKMLTTNAKLRKEIEDLRFEKAAYD 193
+ + K + A Q+++H L + + V + + +++++ E +
Sbjct: 2094 EAALVEKGEFALRLSSTQEEVHQLRRGIEKLRVRIEADEKKQLHIAEKLKERERENDSLK 2153
Query: 194 NVYQQLQHCLLMEKKTMNLAIEQSSQAYEQRVEAMARMAAMKDRQKKDTSQYNLEIRELE 253
+ + L+ L M ++ L I + + K + +I E+
Sbjct: 2154 DKVENLERELQMSEENQELVILDA------------------ENSKAEVETLKTQIEEMA 2195
Query: 254 RLYAHESKLKSFLLVKLNDRNEFEEQAKREEALKAKKHVKKNRGESFESYEVAHLRLLKL 313
R LK F L + R+E E K+ +++ +G+ E
Sbjct: 2196 R------SLKVFELDLVTLRSEKENLTKQ---------IQEKQGQLSE------------ 2228
Query: 314 AESGNLNQLIEDFLAK-EEKNFARFTYVTELNNDMEMMHKRTQRIQDEIILLRSQQKLSH 372
L++L+ F + EEK A E +EM+ + + + + + L Q+
Sbjct: 2229 -----LDKLLSSFKSLLEEKEQAEIQIKEESKTAVEMLQNQLKELNEAVAALCGDQE--- 2280
Query: 373 DDNHSVLRQLEDKLRKTTEEADMYESKYGEVSKTLDLLKNSVEKLFKKINCDATK---IL 429
+++ E L EE L+NS+EKL ++ D K +L
Sbjct: 2281 -----IMKATEQSLDPPIEEEHQ--------------LRNSIEKLRARLEADEKKQLCVL 2321
Query: 430 VQLGETGKVTDINLPQYFAIIEKKTNDLLLLETYRR--ILEVEGAEAEI 476
QL E+ D+ + +E +L + T + LE E ++ E+
Sbjct: 2322 QQLKESEHHADLLKGR----VENLERELEIARTNQEHAALEAENSKGEV 2366
Score = 42.0 bits (97), Expect = 0.002
Identities = 78/437 (17%), Positives = 176/437 (40%), Gaps = 52/437 (11%)
Query: 14 TPQEPSEKAKEQQAEAELRKLRQQFRKMVESRKSFKFRNQQKIASQYKEIKTLKTEQDEI 73
T Q K E +L+KL + ++ +S + +QKI + KE + + Q
Sbjct: 347 TAQYDQASTKYTALEQKLKKLTEDLSCQRQNAESARCSLEQKIKEKEKEFQEELSRQQRS 406
Query: 74 --TLLLSLMKSSRNMNRSEKNYMELRLLLQTKEDYEALIKSLKVLLAELDEKILQMEKKI 131
TL ++ + + + + +LQ + D +K +L+ + + ++K+
Sbjct: 407 FQTLDQECIQMKARLTQELQQAKNMHNVLQAELDKLTSVKQ------QLENNLEEFKQKL 460
Query: 132 ANQKQIFAKMQEANNPRKLQKQIHILETRLNLVTVHFDKMLTTNAKLRKEIEDLRFEKAA 191
+Q F Q N +L++ + ++ NL+ H ++ L E+++++
Sbjct: 461 CRAEQAFQASQIKEN--ELRRSMEEMKKENNLLKSHSEQKAREVCHLEAELKNIKQCLNQ 518
Query: 192 YDNVYQQLQHCLLMEKKTMNLAIEQSSQAYEQRVEAMARMAAMKDRQKKDTSQYNLEIRE 251
N ++++ ++ + E+ +Q ++A +++D SQ L+ RE
Sbjct: 519 SQNFAEEMKAKNTSQETMLRDLQEKINQQENSLTLEKLKLAVADLEKQRDCSQDLLKKRE 578
Query: 252 ------LERLYAHESKLKSFLLVKLNDRNEFEE-----------QAKREEALKAKKHVKK 294
++L E + K+ L + E+EE +++ E+ L + K+
Sbjct: 579 HHIEQLNDKLSKTEKESKALLSALELKKKEYEELKEEKTLFSCWKSENEKLLTQMESEKE 638
Query: 295 N------------RGESFESYEV-AHLRLLKL------AESGNLNQLIEDFLAKEEKNFA 335
N + + +S+E +R L++ E NL+ +++ + E
Sbjct: 639 NLQSKINHLETCLKTQQIKSHEYNERVRTLEMDRENLSVEIRNLHNVLDSKSVEVETQ-- 696
Query: 336 RFTYVTELNNDMEMMHKRTQRIQDEIILLRSQQKLSHDDNHSVLRQLEDKLRKTTEEADM 395
+ Y+ EL E ++ Q+ + + L SQ +D L+ L +++ ++
Sbjct: 697 KLAYM-ELQQKAEFSDQKHQKEIENMCLKTSQLTGQVEDLEHKLQLLSNEI---MDKDRC 752
Query: 396 YESKYGEVSKTLDLLKN 412
Y+ + E DLLK+
Sbjct: 753 YQDLHAEYESLRDLLKS 769
Score = 37.4 bits (85), Expect = 0.037
Identities = 97/522 (18%), Positives = 213/522 (40%), Gaps = 85/522 (16%)
Query: 15 PQEPSEKAKEQQAEAE-LRKLRQQFRKMVESRKSFKFRNQQKIASQYKEIKTLKTEQDEI 73
P +K +E + + + L+K +QQ + ++S ++ + +QK+ ++ E LK E +
Sbjct: 13 PTRALQKIQELEGQLDKLKKEKQQRQFQLDSLEAALQKQKQKVENEKTEGTNLKRENQRL 72
Query: 74 TLLLSLMKSSRNMNRSEKNYMELRLLLQTKEDYEALIKSLKVLLAELDEKILQMEKKIAN 133
+ ++ ++ E E ++ Q E + S K + +L++++ + + ++
Sbjct: 73 MEICESLEKTKQKISHELQVKESQVNFQ-----EGQLNSGKKQIEKLEQELKRCKSELER 127
Query: 134 QKQIF----AKMQEANNPRK-----LQKQIHILETRLNLVTVHFDKMLTTNAKLRKEIED 184
+Q + N P+K L + ++ + ++K + +L E++
Sbjct: 128 SQQAAQSADVSLNPCNTPQKIFTTPLTPSQYYSGSKYEDLKEKYNKEVEERKRLEAEVKA 187
Query: 185 LRFEKAAYDNVYQQLQH-------------CLLMEKKTMNLAIEQS--------SQAY-- 221
L+ +KA+ + H EK +L+ S +Y
Sbjct: 188 LQAKKASQTLPQATMNHRDIARHQASSSVFSWQQEKTPSHLSSNSQRTPIRRDFSASYFS 247
Query: 222 -EQRVEAM------------------ARMAAMKDRQKKDTSQYNLEIRELE-RLYAHESK 261
EQ V + + D+ K + +I ELE RL HE +
Sbjct: 248 GEQEVTPSRSTLQIGKRDANSSFFDNSSSPHLLDQLKAQNQELRNKINELELRLQGHEKE 307
Query: 262 LKSFLLVKLNDRNEFEEQAKRE--EALKAKKHVKKNRGE---SFESYEVAHLRLLKLAES 316
+K ++N E + Q ++ E ++ +K + K R E + Y+ A + L +
Sbjct: 308 MKG----QVNKFQELQLQLEKAKVELIEKEKVLNKCRDELVRTTAQYDQASTKYTALEQ- 362
Query: 317 GNLNQLIEDFLAKEEKNFARFTYVTELNNDMEMMHKRTQRIQDEIILLRSQQKLSHDDNH 376
L +L ED L+ + +N E + + ++ + Q+E L R Q+ D
Sbjct: 363 -KLKKLTED-LSCQRQNAESARCSLE-----QKIKEKEKEFQEE--LSRQQRSFQTLDQE 413
Query: 377 SV--LRQLEDKLRKTTEEADMYESKYGEVSKTLDLLKNSVEKLFKKINCDATKILVQLGE 434
+ +L +L++ ++ +++ +++ L+N++E+ FK+ C A Q +
Sbjct: 414 CIQMKARLTQELQQAKNMHNVLQAELDKLTSVKQQLENNLEE-FKQKLCRAE----QAFQ 468
Query: 435 TGKVTDINLPQYFAIIEKKTNDLLLLETYRRILEVEGAEAEI 476
++ + L + + KK N+LL + ++ EV EAE+
Sbjct: 469 ASQIKENELRRSMEEM-KKENNLLKSHSEQKAREVCHLEAEL 509
Score = 31.6 bits (70), Expect = 2.0
Identities = 82/468 (17%), Positives = 177/468 (37%), Gaps = 58/468 (12%)
Query: 2 SVLKKNRRKDSDTPQEPSEKAKEQQAEAEL-RKLRQQFRKMVESRKSFKFRN----QQKI 56
S L++ +TP P++ +E ++ E+ R+ ++ + +ES+ K + +Q +
Sbjct: 1529 SSLQEENLTRKETPSAPAKGVEELESLCEVYRQSLEKLEEKMESQGIMKNKEIQELEQLL 1588
Query: 57 ASQYKEIKTLKTE--------QDEITLLLSLMKSSRNMNRSEKNYMELRLLLQTKEDYEA 108
+S+ +E+ L+ + Q ++T + M+S + + + L L + + +
Sbjct: 1589 SSERQELDCLRKQYLSENEQWQQKLTSVTLEMESKLAAEKKQTEQLSLELEV-ARLQLQG 1647
Query: 109 LIKSLKVLLAELDEKILQMEKKIANQKQIFAKMQEANNPRKLQKQIHILETRLNLVTVHF 168
L S + LL E +Q + + + P+ QI + + +L +
Sbjct: 1648 LDLSSRSLLGIDTEDAIQGRNESCDISKEHTSETTERTPKHDVHQICDKDAQQDL-NLDI 1706
Query: 169 DKMLTTNAKLR------KEIEDLRFEKAAYDNVYQQLQHCLLMEKKTMNLAIEQSSQAYE 222
+K+ T A ++ D +E D + + N + +
Sbjct: 1707 EKITETGAVKPTGECSGEQSPDTNYEPPGEDKTQGSSECISELSFSGPNALVPMDFLGNQ 1766
Query: 223 QRVEAMARMAAMKDRQKKDTSQYNLEI--------RELERLYAHESKLKSFL-LVKLNDR 273
+ + + + K+TS NL + R++E L +L S L L ++
Sbjct: 1767 EDIHNL-------QLRVKETSNENLRLLHVIEDRDRKVESLLNEMKELDSKLHLQEVQLM 1819
Query: 274 NEFEEQAKREEALKAKKHVKKNRGESFESYEVAHLRLLKLAE-SGNLNQLIEDFLAKEEK 332
+ E + E+ + K + E E + H LL+ E S LN +E K +
Sbjct: 1820 TKIEACIELEKIVGELKKENSDLSEKLEYFSCDHQELLQRVETSEGLNSDLEMHADKSSR 1879
Query: 333 -----NFARFT-----YVTELNNDMEMMHKRTQRIQDEIILLRSQQKL----------SH 372
N A+ ++ N++ + I+ E + L + ++ +
Sbjct: 1880 EDIGDNVAKVNDSWKERFLDVENELSRIRSEKASIEHEALYLEADLEVVQTEKLCLEKDN 1939
Query: 373 DDNHSVLRQLEDKLRKTTEEADMYESKYGEVSKTLDLLKNSVEKLFKK 420
++ V+ LE++L T E + + +SK L EK+ +K
Sbjct: 1940 ENKQKVIVCLEEELSVVTSERNQLRGELDTMSKKTTALDQLSEKMKEK 1987
>gi|71061468 centromere protein E [Homo sapiens]
Length = 2701
Score = 60.5 bits (145), Expect = 4e-09
Identities = 93/420 (22%), Positives = 181/420 (43%), Gaps = 38/420 (9%)
Query: 16 QEPSEKAKEQQAEA-ELRKLRQQFRKM---VESRKSFKFRNQQKIASQYKEIKTLKTEQD 71
QE EK +E Q E+ +L++Q +++ + K +K+ +E+KTL E+D
Sbjct: 873 QELQEKTREVQERLNEMEQLKEQLENRDSTLQTVEREKTLITEKLQQTLEEVKTLTQEKD 932
Query: 72 EITLLLSLMKSSRNMNRSEKNYMELRLLLQTKEDYEALIKSLKVLLAELDEKILQMEKKI 131
++ L ++ R+ +S+ + + + + T+E ++SLK + E I ++ KI
Sbjct: 933 DLKQLQESLQIERDQLKSD-IHDTVNMNIDTQEQLRNALESLK----QHQETINTLKSKI 987
Query: 132 ANQKQIFAKMQEANNPRK--LQKQIHILETRLNLVTVHFDKMLTTNAKLRKEIEDLR--F 187
+ + M+E K Q+++ ++ + +L + + LT + K + IE R F
Sbjct: 988 SEEVSRNLHMEENTGETKDEFQQKMVGIDKKQDLEAKN-TQTLTADVKDNEIIEQQRKIF 1046
Query: 188 EKAAYDNVYQQLQHCLLMEKKTMNLAIEQSSQAYEQRVEAMARMAAMKDRQKKDTSQYNL 247
N QQ+ ++ EK+ + ++++ E +E + + D KK Q +
Sbjct: 1047 SLIQEKNELQQMLESVIAEKEQLKTDLKEN---IEMTIENQEELRLLGDELKK---QQEI 1100
Query: 248 EIRELERLYAHESKLKSFLLVKLNDRNEFEEQAKREEALKAK-KHVKKNRGESFESYEVA 306
+E E +L + A+ EE LK K + +++ + + E
Sbjct: 1101 VAQEKNHAIKKEGELS----------RTCDRLAEVEEKLKEKSQQLQEKQQQLLNVQEEM 1150
Query: 307 HLRLLKLAESGNL-NQLIEDFLAKEEKNFARFTYVTELNNDMEMMHKRTQRIQDEIILLR 365
K+ E NL N+L L E R +LN + E + T ++ +L
Sbjct: 1151 SEMQKKINEIENLKNELKNKELTLEHMETERLELAQKLNENYEEVKSIT---KERKVLKE 1207
Query: 366 SQQKLSHDDNH--SVLRQLEDKLRKTTEEADMYESKYGEVSKTLDLLKNSV-EKLFKKIN 422
Q+ + +H +R++E +T EE + E +T+D L+ SV EK + IN
Sbjct: 1208 LQKSFETERDHLRGYIREIEATGLQTKEELKIAHIHLKEHQETIDELRRSVSEKTAQIIN 1267
Score = 55.8 bits (133), Expect = 1e-07
Identities = 95/507 (18%), Positives = 221/507 (43%), Gaps = 77/507 (15%)
Query: 24 EQQAEAELRKLRQQFRKMVESRKSFKFRNQQKIASQYKEIKTLKTEQDEITLLLSLMKSS 83
++Q EA KL+ + +++ E + F + ++ + E+K K + L ++S
Sbjct: 1511 QKQLEAINDKLQNKIQEIYEKEEQFNIKQISEVQEKVNELKQFKEHRKAKDSALQSIESK 1570
Query: 84 --RNMNRSEKNYMELRLLLQTKEDYEALIKSLKVLLAELDEKILQMEKKIANQKQIFAKM 141
NR +++ E++++++ KE+ + + ++L++ +L E N K+I AKM
Sbjct: 1571 MLELTNRLQESQEEIQIMIKEKEEMKRVQEALQIERDQLKE----------NTKEIVAKM 1620
Query: 142 QEANNPR-KLQKQIHILETRLNLVTVHFDKMLTTNAKLRK---EIEDLRFEKAAYDNVYQ 197
+E+ + K + ET+ + + K KL E E++R + ++N+ +
Sbjct: 1621 KESQEKEYQFLKMTAVNETQEKMCEIEHLKEQFETQKLNLENIETENIRLTQILHENLEE 1680
Query: 198 QLQHCLLMEKKTMNLAIEQSSQAYEQRVEAMARMAAMKDRQKKDTSQ-YNLEIRELERLY 256
+ E+ + ++E++ + +++ R +D +K++ + ++ ++E +
Sbjct: 1681 --MRSVTKERDDLR-SVEETLKVERDQLKENLRETITRDLEKQEELKIVHMHLKEHQETI 1737
Query: 257 AHESKLKSFLLVKLNDRNEFEEQAKR-EEALKAK------------KHVKKNRGESFESY 303
KL+ + K N+ + ++ + +ALKA+ H+K+ + +
Sbjct: 1738 ---DKLRGIVSEKTNEISNMQKDLEHSNDALKAQDLKIQEELRIAHMHLKEQQETIDKLR 1794
Query: 304 EVAHLRLLKLA--------ESGNLNQLIEDFLAKEEKNFARFTYVTELNNDMEMMHKRTQ 355
+ + KL+ + L + I++ A E + V E + M + +
Sbjct: 1795 GIVSEKTDKLSNMQKDLENSNAKLQEKIQELKANEHQLITLKKDVNETQKKVSEMEQLKK 1854
Query: 356 RIQD--------EIILLRSQQKLSH--DDNHSVLRQLE-------------DKLRKTTEE 392
+I+D EI L QKL ++ SV+++ + D+L+++ +E
Sbjct: 1855 QIKDQSLTLSKLEIENLNLAQKLHENLEEMKSVMKERDNLRRVEETLKLERDQLKESLQE 1914
Query: 393 ADMYESKYGEVSKTLDLL----KNSVEKLFKKINCDATKILVQLGETGKVTDINLPQYFA 448
+ + + KT +L K +V+KL +KI+ +I + K D L +
Sbjct: 1915 TKARDLEIQQELKTARMLSKEHKETVDKLREKISEKTIQISDIQKDLDKSKD-ELQKKIQ 1973
Query: 449 IIEKKTNDLLLLE-----TYRRILEVE 470
++KK LL ++ ++++I E+E
Sbjct: 1974 ELQKKELQLLRVKEDVNMSHKKINEME 2000
Score = 53.5 bits (127), Expect = 5e-07
Identities = 85/424 (20%), Positives = 181/424 (42%), Gaps = 35/424 (8%)
Query: 4 LKKNRRKDSDTPQEPSEKAKEQQAEAELRKLRQQFRKMVESRKSFKFRNQQKIASQYKEI 63
L++ +++ + +E SE K+ L+ + +E ++ + QK+ Y+E+
Sbjct: 1136 LQEKQQQLLNVQEEMSEMQKKINEIENLKNELKNKELTLEHMETERLELAQKLNENYEEV 1195
Query: 64 KTLKTEQDEITLLLSLMKSSRNMNRSEKNYMELRLLLQTKEDYEALIKSLKVLLAELDEK 123
K++ E+ + L ++ R+ R +E LQTKE+ +K + L E E
Sbjct: 1196 KSITKERKVLKELQKSFETERDHLRGYIREIE-ATGLQTKEE----LKIAHIHLKEHQET 1250
Query: 124 ILQMEKKIANQ-KQIFAKMQEANNPRKLQKQIHILETRLNLVTVHFDKMLTTNAKLRKEI 182
I ++ + ++ + QI + KLQ++I +L L+ K ++ + E+
Sbjct: 1251 IDELRRSVSEKTAQIINTQDLEKSHTKLQEEIPVLHEEQELLP--NVKEVSETQETMNEL 1308
Query: 183 EDLRFEKAAYDNVYQQLQHCLLMEKKTMNLAIEQSSQAYEQRVEAMARMAAMKDRQKKDT 242
E L + D+ + ME+ +N ++S + + + + +K+ +
Sbjct: 1309 ELLTEQSTTKDSTTLAR---IEMERLRLNEKFQESQEEIKSLTKERDNLKTIKEALEVKH 1365
Query: 243 SQYNLEIRE-LERLYAHESKLKSFLLVKLNDRNEFEEQAKREEALKAKKHVKKNRGESFE 301
Q IRE L ++ +SK + L +K D NE + E K K +
Sbjct: 1366 DQLKEHIRETLAKIQESQSKQEQSLNMKEKD-NETTKIVSEMEQFKPK-------DSALL 1417
Query: 302 SYEVAHLRLLK-LAESGNLNQLIEDFLAKEEKNFARFTYVTELNNDMEMMHKRTQRIQDE 360
E+ L L K L ES + + + AKE+ + R V L ++ + + + + I +
Sbjct: 1418 RIEIEMLGLSKRLQESHDEMKSV----AKEKDDLQRLQEV--LQSESDQLKENIKEIVAK 1471
Query: 361 IILLRSQQKLSHDDNHSVLRQLEDKLRKTTEEADMYESKYGEVSKTL----DLLKNSVEK 416
+ + K++ H L++ E+ + + E++ + K L D L+N +++
Sbjct: 1472 HLETEEELKVA----HCCLKEQEETINELRVNLSEKETEISTIQKQLEAINDKLQNKIQE 1527
Query: 417 LFKK 420
+++K
Sbjct: 1528 IYEK 1531
Score = 51.2 bits (121), Expect = 2e-06
Identities = 82/416 (19%), Positives = 190/416 (45%), Gaps = 70/416 (16%)
Query: 7 NRRKDSDTPQEPSEKAKEQQAEAELRKLRQQFRKMVE---------SRKSFKFRNQQKI- 56
N +KD + + + KA++ + + ELR ++ E S K+ K N QK
Sbjct: 1753 NMQKDLEHSND-ALKAQDLKIQEELRIAHMHLKEQQETIDKLRGIVSEKTDKLSNMQKDL 1811
Query: 57 ----ASQYKEIKTLKTEQDEITLLLSLMKSSRNMNRSEKNYMELRLLLQTKEDYEALIKS 112
A ++I+ LK + ++ L +++N ++K E+ E + IK
Sbjct: 1812 ENSNAKLQEKIQELKANEHQLITL------KKDVNETQKKVSEM-------EQLKKQIKD 1858
Query: 113 LKVLLAELDEKILQMEKKI-ANQKQIFAKMQEANNPRKLQKQIHILETRLNLVTVHFDKM 171
+ L++L+ + L + +K+ N +++ + M+E +N R++++ + + +L + +
Sbjct: 1859 QSLTLSKLEIENLNLAQKLHENLEEMKSVMKERDNLRRVEETLKLERDQLK------ESL 1912
Query: 172 LTTNAK---LRKEIEDLRFEKAAYDNVYQQLQHCLLMEKKTMNLA-----IEQSSQAYEQ 223
T A+ +++E++ R + +L+ + +KT+ ++ +++S ++
Sbjct: 1913 QETKARDLEIQQELKTARMLSKEHKETVDKLREKI--SEKTIQISDIQKDLDKSKDELQK 1970
Query: 224 RVEAMARMAAMKDRQKKDTSQYNLEIRELERLYAH-ESKLKSFLLVKLNDRNEFEEQAKR 282
+++ + + R K+D + + +I E+E+L E++ S V++++ F+ K
Sbjct: 1971 KIQELQKKELQLLRVKEDVNMSHKKINEMEQLKKQFEAQNLSMQSVRMDN---FQLTKKL 2027
Query: 283 EEALKAKKHVKKNRGESFESYEVAHLRLLKLAESGNLNQLI---EDFLAKEEKNFARFTY 339
E+L+ + V K R E LR +K + +Q I + +A++ +N
Sbjct: 2028 HESLEEIRIVAKERDE---------LRRIKESLKMERDQFIATLREMIARDRQNHQVKPE 2078
Query: 340 VTELNNDM----EMMHKRTQRIQDEIILLRSQQKLSHDDNHSVLRQLEDKLRKTTE 391
L++ E + ++ RI++ LL+ ++ DD++ L +L L K E
Sbjct: 2079 KRLLSDGQQHLTESLREKCSRIKE---LLKRYSEM--DDHYECLNRLSLDLEKEIE 2129
Score = 49.7 bits (117), Expect = 7e-06
Identities = 101/471 (21%), Positives = 201/471 (42%), Gaps = 89/471 (18%)
Query: 30 ELRKLRQQFRKMVESRKSFKFRNQQ---KIASQYKEIKTLKTEQDEITLLLSLMKSSRN- 85
E+ +L++QF S +S + N Q K+ +EI+ + E+DE+ + +K R+
Sbjct: 1998 EMEQLKKQFEAQNLSMQSVRMDNFQLTKKLHESLEEIRIVAKERDELRRIKESLKMERDQ 2057
Query: 86 --------MNRSEKNYM---ELRLLLQTKEDY-EAL------IKSLKVLLAELDEKI--- 124
+ R +N+ E RLL ++ E+L IK L +E+D+
Sbjct: 2058 FIATLREMIARDRQNHQVKPEKRLLSDGQQHLTESLREKCSRIKELLKRYSEMDDHYECL 2117
Query: 125 ----LQMEKKIANQKQIFAKMQEANNPRKLQ-KQIHILETRLNLVTVHFDKM-------L 172
L +EK+I QK++ +++ + LQ K I L T ++ F ++ L
Sbjct: 2118 NRLSLDLEKEIEFQKELSMRVKANLSLPYLQTKHIEKLFTANQRCSMEFHRIMKKLKYVL 2177
Query: 173 TTNAKLRKEIEDL--RFEKAAYDNVYQQ------LQH----CLLMEKKTMNLAIEQSSQA 220
+ K+++E + +FE D V +Q +QH C + ++ +L + Q+
Sbjct: 2178 SYVTKIKEEQHESINKFEMDFIDEVEKQKELLIKIQHLQQDCDVPSRELRDLKLNQNMDL 2237
Query: 221 YEQRVEAMARMAAMKDRQKKDTSQYNLEIRELERLYAHESKLKSFLLVKLNDRNEFEEQA 280
+ + + +KD + S++ E +++ ++ ++ FL LN R + E
Sbjct: 2238 HIEEI--------LKDFSE---SEFPSIKTEFQQVLSNRKEMTQFLEEWLNTRFDIE--- 2283
Query: 281 KREEALKAKKHVKKNRGESFESYEVAHLRLLKLAE------------SGNLNQLIEDFLA 328
K K ++K + + R++ + S Q ++
Sbjct: 2284 ------KLKNGIQKENDRICQVNNFFNNRIIAIMNESTEFEERSATISKEWEQDLKSLKE 2337
Query: 329 KEEKNFARF-TYVTELNNDMEMMHKRTQRIQDEIILLRSQQKLSHDDNHSVLRQLEDKLR 387
K EK F + T T L + ++ + TQ ++ + R+ Q + +R+LE+ L
Sbjct: 2338 KNEKLFKNYQTLKTSLASGAQV-NPTTQDNKNPHVTSRATQLTTEK-----IRELENSLH 2391
Query: 388 KTTEEADMYESKYGEVSKTLDLLKNSVEKLFKKINCDATKILVQLGETGKV 438
+ E A ESK ++ K L++ + + KL K++ ++ K L + ET +V
Sbjct: 2392 EAKESAMHKESKIIKMQKELEVTNDIIAKLQAKVH-ESNKCLEKTKETIQV 2441
Score = 48.1 bits (113), Expect = 2e-05
Identities = 92/480 (19%), Positives = 198/480 (41%), Gaps = 60/480 (12%)
Query: 2 SVLKKNRRKDSDTPQEPSEKAKEQQAEAELRKLRQQFRKMVESRKSFKFRNQQKIASQYK 61
++LK+ R++ D ++ E + E +A+A + Q +++E + + +KI + +
Sbjct: 343 ALLKRYRKEIMDLKKQLEEVSLETRAQA---MEKDQLAQLLEEKDLLQKVQNEKIENLTR 399
Query: 62 EIKT---LKTEQD-------EITLLLSLMKSSRNMNRSEKNYMELRLLLQTKEDYEALIK 111
+ T L +Q+ +T L + +N N +++ + + +T +
Sbjct: 400 MLVTSSSLTLQQELKAKRKRRVTWCLGKINKMKNSNYADQFNIPTNITTKTHK------- 452
Query: 112 SLKV-LLAELDEKILQMEKKIANQKQIFAKMQEANNPRKLQKQIHILETRLNLVTVHFDK 170
L + LL E+DE + +N +++ E N KL Q +I E+ LN + +D
Sbjct: 453 -LSINLLREIDESVCSESDVFSNTLDTLSEI-EWNPATKLLNQENI-ESELNSLRADYDN 509
Query: 171 MLTTNAKLRKEIEDLRF--------------EKAAYDNVYQQLQHCLLMEKKTMNLAIEQ 216
++ +LR E E++ E+ + QL H + K + A E
Sbjct: 510 LVLDYEQLRTEKEEMELKLKEKNDLDEFEALERKTKKDQEMQLIHEISNLKNLVKHA-EV 568
Query: 217 SSQAYEQRVEAMARMAAMKDRQKKDTSQYNLEIRELERLYAHESKLKSFLLVKLNDRNEF 276
+Q E + + + K+ Q K +Y ++ ++LE + S+ L + D +
Sbjct: 569 YNQDLENELSSKVELLREKEDQIKKLQEY-IDSQKLENIKMD----LSYSLESIEDPKQM 623
Query: 277 EEQAKREE--ALKAKKHVKKNRGESFESYEVAHLRLLKLAESGNLNQLIEDFLAKEEKNF 334
++ E AL AK+ R E+ E E + N QL + L ++K
Sbjct: 624 KQTLFDAETVALDAKRESAFLRSENLELKEKMKELATTYKQMENDIQLYQSQLEAKKKMQ 683
Query: 335 --------ARFTYVTELNNDMEMMHKR----TQRIQDEIILLRSQQKLSHDDNHSVLRQ- 381
+ F +T+L + ++ + ++ +I L+ + ++N ++ +
Sbjct: 684 VDLEKELQSAFNEITKLTSLIDGKVPKDLLCNLELEGKITDLQKELNKEVEENEALREEV 743
Query: 382 -LEDKLRKTTEEADMYESKYGEVSKTLDLLKNSVEKLFKKINCDATKILVQLGETGKVTD 440
L +L+ E + + + S+ L ++ + +KLF ++ +++ L E GK D
Sbjct: 744 ILLSELKSLPSEVERLRKEIQDKSEELHIITSEKDKLFSEVVHKESRVQGLLEEIGKTKD 803
>gi|208022632 coiled-coil domain containing 88A isoform 1 [Homo
sapiens]
Length = 1870
Score = 59.7 bits (143), Expect = 7e-09
Identities = 105/482 (21%), Positives = 196/482 (40%), Gaps = 97/482 (20%)
Query: 19 SEKAKEQQAEAELRKLRQQFRKMVESRKSFKFRNQQKIASQYKEI---------KTLKTE 69
SEK K QQ +L KL + K + K ++Q +YK + K+L+ +
Sbjct: 913 SEKLKTQQMNNDLEKLTHELEK-IGLNKERLLHDEQSTDDRYKLLESKLESTLKKSLEIK 971
Query: 70 QDEITLLLSLMKSSRNMNRS--------EKNYMELRLLLQTKEDYEALIKSLKVL----- 116
+++I L + ++ S N N+ +KNY L+ ++D E +++S +
Sbjct: 972 EEKIAALEARLEESTNYNQQLRQELKTVKKNYEALK----QRQDEERMVQSSPPISGEDN 1027
Query: 117 ------------LAELDEKILQMEKKIAN---QKQIFA---KMQEANNPRKLQKQIHILE 158
L ++ ++++++E+ A +KQ K E N LQ QI L+
Sbjct: 1028 KWERESQETTRELLKVKDRLIEVERNNATLQAEKQALKTQLKQLETQN-NNLQAQILALQ 1086
Query: 159 TRLNLVTVHFDKMLTTNAKLRKEIEDLRFEKAAYDNVYQQL---QHCLLMEKKTMNLAIE 215
+ + + T NAKL+ E L + + N QL Q L E +++ E
Sbjct: 1087 RQTVSLQEQNTTLQTQNAKLQVENSTLNSQSTSLMNQNAQLLIQQSSLENENESVIKERE 1146
Query: 216 QSSQAYEQRVEAMARMAAMKDRQKKD------------TSQYNLEI--RELERLYAHESK 261
Y+ ++ ++ + +RQ + ++ NLE+ R+LE Y K
Sbjct: 1147 DLKSLYDSLIKDHEKLELLHERQASEYESLISKHGTLKSAHKNLEVEHRDLEDRYNQLLK 1206
Query: 262 LKSFLLVKLNDRNEFEEQAKREEALKAKKH------VKKNRGESFESYEVAHLRLLKLAE 315
K +L D + + + + L+ K H KK GE+ + + +LLK E
Sbjct: 1207 QKG----QLEDLEKMLKVEQEKMLLENKNHETVAAEYKKLCGEN-DRLNHTYSQLLKETE 1261
Query: 316 -----SGNLNQLIEDFLAKEEKNFARFTYV-----------TELNNDMEMMHKRTQRIQD 359
NL L+ + ++ + A F+ + T+LNN E++ + +++
Sbjct: 1262 VLQTDHKNLKSLLNNSKLEQTRLEAEFSKLKEQYQQLDITSTKLNNQCELLSQLKGNLEE 1321
Query: 360 EIILLRSQQKLSHDDNHSVLRQLEDKLRKTTEEADMYESKYGEVSKTLDLLKNSVEKLFK 419
E L Q + N ++L Q E D++ + + L+ L+ EKL +
Sbjct: 1322 ENRHLLDQIQTLMLQNRTLLEQ-------NMESKDLFHVEQRQYIDKLNELRRQKEKLEE 1374
Query: 420 KI 421
KI
Sbjct: 1375 KI 1376
Score = 58.2 bits (139), Expect = 2e-08
Identities = 84/430 (19%), Positives = 187/430 (43%), Gaps = 37/430 (8%)
Query: 5 KKNRRKDSDTPQEPSEKAKEQQAEAELRKLRQQFRKMVESRKSFKFRNQQKIASQYKEIK 64
K+N+ + +T Q +K +Q E E ++LRQQ E + + N KI + KE K
Sbjct: 815 KENKSLEQETSQLEKDK---KQLEKENKRLRQQ----AEIKDTTLEENNVKIGNLEKENK 867
Query: 65 TLKTE----QDEITLLLSLMKSSRNMNRSEKNYMELRLLLQTKEDYEALIKSLKVLLAEL 120
TL E ++ L L K ++ + + + ++++ L+ +ED + + + +L
Sbjct: 868 TLSKEIGIYKESCVRLKELEKENKELVK--RATIDIKTLVTLREDLVSEKLKTQQMNNDL 925
Query: 121 DEKILQMEKKIANQKQIFAKMQEANNPRKL---------QKQIHILETRLNLVTVHFDKM 171
++ ++EK N++++ Q ++ KL +K + I E ++ + ++
Sbjct: 926 EKLTHELEKIGLNKERLLHDEQSTDDRYKLLESKLESTLKKSLEIKEEKIAALEARLEES 985
Query: 172 LTTNAKLRKEIEDLRFEKAAYDNVYQQLQHCLLMEKKTMNLAIEQSSQAYEQRVEAMARM 231
N +LR+E++ ++ A +Q Q M + + ++ E + E + E +
Sbjct: 986 TNYNQQLRQELKTVKKNYEAL----KQRQDEERMVQSSPPISGEDNKWERESQ-ETTREL 1040
Query: 232 AAMKDRQ---KKDTSQYNLEIR----ELERLYAHESKLKSFLLVKLNDRNEFEEQAKREE 284
+KDR +++ + E + +L++L + L++ +L +EQ +
Sbjct: 1041 LKVKDRLIEVERNNATLQAEKQALKTQLKQLETQNNNLQAQILALQRQTVSLQEQNTTLQ 1100
Query: 285 ALKAKKHVKKNRGESFESYEVAHLRLLKLAESGNLNQLIEDFLAKEEKNFARFTYVTELN 344
AK V+ + S +S + + L + +L E + + E + + + + +
Sbjct: 1101 TQNAKLQVENSTLNS-QSTSLMNQNAQLLIQQSSLENENESVIKEREDLKSLYDSLIKDH 1159
Query: 345 NDMEMMHKRTQRIQDEIILLRSQQKLSHDDNHSVLRQLEDKLRKTTEEADMYE--SKYGE 402
+E++H+R + +I K +H + R LED+ + ++ E K +
Sbjct: 1160 EKLELLHERQASEYESLISKHGTLKSAHKNLEVEHRDLEDRYNQLLKQKGQLEDLEKMLK 1219
Query: 403 VSKTLDLLKN 412
V + LL+N
Sbjct: 1220 VEQEKMLLEN 1229
Score = 54.7 bits (130), Expect = 2e-07
Identities = 94/433 (21%), Positives = 181/433 (41%), Gaps = 93/433 (21%)
Query: 22 AKEQQAEAELRKLRQQFRKMVESRK-SFKFRNQQKIASQYKEI------KTLKTEQDEIT 74
A+ Q EL ++Q +K +E K SFK + +++ Q +I KTL+ +I
Sbjct: 721 AQLQLENKELESEKEQLKKGLELLKASFKKTERLEVSYQGLDIENQRLQKTLENSNKKIQ 780
Query: 75 LLLSLMKSSRNMNRS-EKNYMELRLLLQTKEDYEALIKSLKVLLAELDEKILQMEKKIAN 133
L S ++ N++ +KN EL++ + E E KSL+ ++L++ Q+EK+
Sbjct: 781 QLESELQDLEMENQTLQKNLEELKISSKRLEQLEKENKSLEQETSQLEKDKKQLEKE--- 837
Query: 134 QKQIFAKMQEANNPRKLQKQIHILETRLNLVTVHFDKMLTTNAKLRKEIEDLRFEKAAYD 193
++L++Q I +T L V + N L KEI
Sbjct: 838 -------------NKRLRQQAEIKDTTLEENNVKIGNLEKENKTLSKEI----------- 873
Query: 194 NVYQQLQHCLLMEKKTMNLAIEQSSQAYEQRVEAMARMAAMKD--RQKKDTSQYNLEI-- 249
+Y+ + C+ +++ L E ++ + +D +K T Q N ++
Sbjct: 874 GIYK--ESCVRLKE----LEKENKELVKRATIDIKTLVTLREDLVSEKLKTQQMNNDLEK 927
Query: 250 --RELERLYAHESKLKSFLLVKLNDRNEFEE-----QAKREEALKAKKHVKKNRGESFES 302
ELE++ ++ +L L+D ++ ++K E LK +K+ + + E+
Sbjct: 928 LTHELEKIGLNKERL-------LHDEQSTDDRYKLLESKLESTLKKSLEIKEEKIAALEA 980
Query: 303 YEVAHLRLLKLAESGNLNQLIEDFLAKEEKNFARFTYVTELNNDMEMMHKRTQRIQDEII 362
+L ES N NQ + L +KN+ E + +R QDE
Sbjct: 981 ---------RLEESTNYNQQLRQELKTVKKNY-------------EALKQR----QDEER 1014
Query: 363 LLRSQQKLSHDDNHSVLRQLEDKLRKTTEEADMYESKYGEVSK---TLDLLKNSVEKLFK 419
+++S +S +DN + E + ++TT E + + EV + TL K +++ K
Sbjct: 1015 MVQSSPPISGEDN-----KWERESQETTRELLKVKDRLIEVERNNATLQAEKQALKTQLK 1069
Query: 420 KINCDATKILVQL 432
++ + Q+
Sbjct: 1070 QLETQNNNLQAQI 1082
Score = 51.2 bits (121), Expect = 2e-06
Identities = 107/549 (19%), Positives = 205/549 (37%), Gaps = 116/549 (21%)
Query: 21 KAKEQQAEAELRKLRQQFRKMVESRKSFKFRNQQKIASQYKEIKTLKTEQDEITLLLSLM 80
KAK E E R++ +++E + + +Q + E L E ++I+ L
Sbjct: 388 KAKLHDMEMERDMDRKKIEELMEENMTLEMAQKQSM----DESLHLGWELEQISRTSELS 443
Query: 81 KSSRNMNRSEKNYMELRLLLQTKEDYEALIKSLKVLLAELDE------KILQMEKK---- 130
++ + E N + LL+ + + ++L K+++ L +D KIL+MEK+
Sbjct: 444 EAPQKSLGHEVNELTSSRLLKLEMENQSLTKTVEELRTTVDSVEGNASKILKMEKENQRL 503
Query: 131 ----------IANQKQIFAKMQEANNP--------------------------------- 147
I +KQ Q +
Sbjct: 504 SKKVEILENEIVQEKQSLQNCQNLSKDLMKEKAQLEKTIETLRENSERQIKILEQENEHL 563
Query: 148 -------------------RKLQKQIHILETRLNLVTVHFDKMLTTNAKLRKEIEDLRFE 188
+ ++K+ IL + + K+ +++KE+E + +
Sbjct: 564 NQTVSSLRQRSQISAEARVKDIEKENKILHESIKETSSKLSKIEFEKRQIKKELEHYKEK 623
Query: 189 KAAYDNVYQQLQHC----LLMEKKTMNLAI---------------EQSSQAYEQRVEAMA 229
+ + +L H L++KK NL I E+ ++ ++ +++
Sbjct: 624 GERAEELENELHHLEKENELLQKKITNLKITCEKIEALEQENSELERENRKLKKTLDSFK 683
Query: 230 RMAAMKDRQKKDTSQY---NLEI-RELERLYAHESKLKSFLLVKLNDRNEFEEQAKREEA 285
+ + +K+ SQ NLE+ R +E L K+ L +E E+ K E
Sbjct: 684 NLTFQLESLEKENSQLDEENLELRRNVESLKCASMKMAQLQLENKELESEKEQLKKGLEL 743
Query: 286 LKAKKHVKKNRGESFESYEVAHLRLLKLAESGN--LNQLIEDFLAKEEKNFARFTYVTEL 343
LKA + S++ ++ + RL K E+ N + QL + E +N + EL
Sbjct: 744 LKASFKKTERLEVSYQGLDIENQRLQKTLENSNKKIQQLESELQDLEMENQTLQKNLEEL 803
Query: 344 ---NNDMEMMHKRTQRIQDEIILLRSQQKLSHDDNHSVLRQLEDK---LRKTTEEADMYE 397
+ +E + K + ++ E L +K +N + +Q E K L + + E
Sbjct: 804 KISSKRLEQLEKENKSLEQETSQLEKDKKQLEKENKRLRQQAEIKDTTLEENNVKIGNLE 863
Query: 398 SKYGEVSKTLDLLKNS------VEKLFKKINCDAT---KILVQLGETGKVTDINLPQYFA 448
+ +SK + + K S +EK K++ AT K LV L E + Q
Sbjct: 864 KENKTLSKEIGIYKESCVRLKELEKENKELVKRATIDIKTLVTLREDLVSEKLKTQQMNN 923
Query: 449 IIEKKTNDL 457
+EK T++L
Sbjct: 924 DLEKLTHEL 932
Score = 49.7 bits (117), Expect = 7e-06
Identities = 78/409 (19%), Positives = 175/409 (42%), Gaps = 41/409 (10%)
Query: 84 RNMNRSEKNYMELRLLLQT---KEDYEALIKS----LKVLLAELDEK---ILQMEKKIAN 133
+ + +++N +L+ + T +ED E L+K+ LK L+ E DE I+++ ++
Sbjct: 161 QEVTHNQENVFDLQWMEVTDMSQEDIEPLLKNMALHLKRLIDERDEHSETIIELSEERDG 220
Query: 134 QKQIFAKMQEANNPRKLQKQIHILETRLNLVTVHFDKMLTTNAKLRKEIEDLRFEKAAYD 193
+ A +P + E+R +L ++ AK+R+ ++L +
Sbjct: 221 LHFLPHASSSAQSPCG-SPGMKRTESRQHLSV----ELADAKAKIRRLRQELEEKTEQLL 275
Query: 194 NVYQQLQHCLL----MEKKTMNLAIE-QSSQAYEQRVEAMARMAAMKDRQKKDTSQYNLE 248
+ Q+L+ + ++++ MNL + +S++ Y ++A+ A D+ + + S+Y
Sbjct: 276 DCKQELEQMEIELKRLQQENMNLLSDARSARMYRDELDALREKAVRVDKLESEVSRYKER 335
Query: 249 IRELERLYAHESKLKSFLLVKLNDRNEFEEQAKREEALKAKKHVKKNRGESFESYEVAHL 308
+ ++E A +LK V L + E+Q + A K H + ++ ++ +
Sbjct: 336 LHDIEFYKARVEELKEDNQVLLETKTMLEDQLEGTRARSDKLHELEKENLQLKA-KLHDM 394
Query: 309 RLLKLAESGNLNQLIEDFLAKE-------EKNFARFTYVTELNNDMEMMHKRTQRIQDEI 361
+ + + + +L+E+ + E +++ + +++ E+ + + E+
Sbjct: 395 EMERDMDRKKIEELMEENMTLEMAQKQSMDESLHLGWELEQISRTSELSEAPQKSLGHEV 454
Query: 362 ILLRSQQKLSHDDNHSVLRQLEDKLRKTTEEADMYESKYGEVSKTLDLLKNSVEKLFKKI 421
L S + L + + L + ++LR T + + SK ++ K L VE L +I
Sbjct: 455 NELTSSRLLKLEMENQSLTKTVEELRTTVDSVEGNASKILKMEKENQRLSKKVEILENEI 514
Query: 422 --------NC-----DATKILVQLGETGKVTDINLPQYFAIIEKKTNDL 457
NC D K QL +T + N + I+E++ L
Sbjct: 515 VQEKQSLQNCQNLSKDLMKEKAQLEKTIETLRENSERQIKILEQENEHL 563
Score = 32.0 bits (71), Expect = 1.6
Identities = 29/113 (25%), Positives = 54/113 (47%), Gaps = 9/113 (7%)
Query: 19 SEKAKEQQAEAELRKLRQQFRKMVESRKSFKFRNQQKIASQYKEIKTLKTEQDEITLLLS 78
+ K ++ + EAE KL++Q++++ S K NQ ++ SQ K ++E LL
Sbjct: 1276 NSKLEQTRLEAEFSKLKEQYQQL--DITSTKLNNQCELLSQLK-----GNLEEENRHLLD 1328
Query: 79 LMKSSRNMNRS--EKNYMELRLLLQTKEDYEALIKSLKVLLAELDEKILQMEK 129
+++ NR+ E+N L + Y + L+ +L+EKI+ K
Sbjct: 1329 QIQTLMLQNRTLLEQNMESKDLFHVEQRQYIDKLNELRRQKEKLEEKIMDQYK 1381
>gi|13124879 smooth muscle myosin heavy chain 11 isoform SM1A [Homo
sapiens]
Length = 1972
Score = 59.7 bits (143), Expect = 7e-09
Identities = 108/483 (22%), Positives = 202/483 (41%), Gaps = 38/483 (7%)
Query: 6 KNRRKDSDTPQEPSEKAKEQQAEAELRKLRQQFRKMVESRKSFKFRNQQKIASQYKEIKT 65
K ++ ++ + S+ + ++A AEL + + VES + K K++ +
Sbjct: 1253 KKKKLEAQVQELQSKCSDGERARAELNDKVHKLQNEVESVTGMLNEAEGKAIKLAKDVAS 1312
Query: 66 LKTE-QDEITLLLSLMKSSRNMNRSEKNYMELRLLLQTKEDYEALIK-SLKVLLAELDEK 123
L ++ QD LL + N++ + E R LQ + D E K +L+ ++ L+ +
Sbjct: 1313 LSSQLQDTQELLQEETRQKLNVSTKLRQLEEERNSLQDQLDEEMEAKQNLERHISTLNIQ 1372
Query: 124 ILQMEKKIANQKQIFAKMQEA--NNPRKLQKQIHILETRLNLVTVHFDKMLTTNAKLRKE 181
+ +KK+ Q FA EA ++ QK+I L + +DK+ T +L++E
Sbjct: 1373 LSDSKKKL----QDFASTVEALEEGKKRFQKEIENLTQQYEEKAAAYDKLEKTKNRLQQE 1428
Query: 182 IEDLRFEKAAYDNVYQQLQHCLLMEKKTMNLAIEQS--SQAY---EQRVEAMARMAAMKD 236
++DL + DN Q + + ++K L E+ S Y R EA AR K
Sbjct: 1429 LDDLVVD---LDNQRQLVSNLEKKQRKFDQLLAEEKNISSKYADERDRAEAEAREKETKA 1485
Query: 237 RQKKDTSQYNLEIR-ELERLYAH-ESKLKSFLLVKLNDRNEFEEQAKREEALKAKKHVKK 294
+ LE + ELER +++++ + K + E K + AL+ + K
Sbjct: 1486 LSLARALEEALEAKEELERTNKMLKAEMEDLVSSKDDVGKNVHELEKSKRALETQMEEMK 1545
Query: 295 NRGESFE----SYEVAHLRLLKLAESGNLNQLIEDFLAKEEKNFARFTYVTELNNDMEMM 350
+ E E + E A LR L++ Q D A++E+N + + +
Sbjct: 1546 TQLEELEDELQATEDAKLR-LEVNMQALKGQFERDLQARDEQNEEKRRQL------QRQL 1598
Query: 351 HKRTQRIQDEIILLRSQQKLSHDDNHSVLRQLEDKLRKTTEEADMYESKYGEVSKTLDLL 410
H+ ++DE R Q+ L+ + ++LE L+ +AD E K L L
Sbjct: 1599 HEYETELEDE----RKQRALA----AAAKKKLEGDLKDLELQADSAIKGREEAIKQLRKL 1650
Query: 411 KNSVEKLFKKINCDATKILVQLGETGKVTDINLPQYFAIIEKKTNDLLLLETYRRILEVE 470
+ ++ +++ DA ++ T K + A + + DL E R+ ++E
Sbjct: 1651 QAQMKDFQRELE-DARASRDEIFATAKENEKKAKSLEADLMQLQEDLAAAERARKQADLE 1709
Query: 471 GAE 473
E
Sbjct: 1710 KEE 1712
Score = 57.8 bits (138), Expect = 3e-08
Identities = 94/427 (22%), Positives = 188/427 (44%), Gaps = 47/427 (11%)
Query: 6 KNRRKDSDTPQEPSEKAKEQQAEAELRKLRQQFRKMVESRKSFKFRNQQKIASQYKEIKT 65
K + ++ + + +E AK + E ++ L+ QF + +++R +N++K +++
Sbjct: 1545 KTQLEELEDELQATEDAK-LRLEVNMQALKGQFERDLQARDE---QNEEKRRQLQRQLHE 1600
Query: 66 LKTEQDEITLLLSLMKSSRNMNRSEKNYMELRLLLQTKEDYEALIKSLKVLLAELDEKIL 125
+TE ++ +L +++ + +EL+ K EA IK L+ L A++ +
Sbjct: 1601 YETELEDERKQRALAAAAKKKLEGDLKDLELQADSAIKGREEA-IKQLRKLQAQMKDFQR 1659
Query: 126 QMEKKIANQKQIFAKMQEANNPRKLQKQIHILETRLNLVTVHFDKMLTTNAKLRKEIEDL 185
++E A++ +IFA +E +K+ LE L + + L + RK+ DL
Sbjct: 1660 ELEDARASRDEIFATAKEN------EKKAKSLEADL----MQLQEDLAAAERARKQA-DL 1708
Query: 186 RFEKAAYDNVYQQL--QHCLLMEKKTMNLAIEQSSQAYEQRVEAMARMAAMKDRQKKDTS 243
E+ A + + L ++ L EK+ + I Q + E E M AM DR +K T
Sbjct: 1709 EKEELA-EELASSLSGRNALQDEKRRLEARIAQLEEELE---EEQGNMEAMSDRVRKATQ 1764
Query: 244 QYNLEIREL--ERLYAHESKLKSFLLVKLNDRNEFEEQAKREEALKAKKHVKKNRGESFE 301
Q EL ER A +++ + R + E Q K L++K H + +S
Sbjct: 1765 QAEQLSNELATERSTAQKNE---------SARQQLERQNKE---LRSKLHEMEGAVKSKF 1812
Query: 302 SYEVAHLRLLKLAESGNLNQLIEDFLAKEEKNFARFTYVTELNNDMEMMHKRTQRIQDEI 361
+A L A+ L + +E EK A L + + + +++DE
Sbjct: 1813 KSTIAALE----AKIAQLEEQVEQ--EAREKQAA----TKSLKQKDKKLKEILLQVEDER 1862
Query: 362 ILLRSQQKLSHDDNHSVLRQLEDKLRKTTEEADMYESKYGEVSKTLDLLKNSVEKLFKKI 421
+ Q K + ++ ++QL+ +L + EE+ + ++ + LD S E + +++
Sbjct: 1863 -KMAEQYKEQAEKGNARVKQLKRQLEEAEEESQRINANRRKLQRELDEATESNEAMGREV 1921
Query: 422 NCDATKI 428
N +K+
Sbjct: 1922 NALKSKL 1928
Score = 53.9 bits (128), Expect = 4e-07
Identities = 91/458 (19%), Positives = 181/458 (39%), Gaps = 54/458 (11%)
Query: 8 RRKDSDTPQEPSEKAKEQQAEAELRKLRQQFRKMVESRKSFKFRNQQKIASQYKEIKTLK 67
+R+ T + + + + EA+++++RQ+ + VE + ++ A+ K +TL+
Sbjct: 1171 KREQEVTVLKKALDEETRSHEAQVQEMRQKHAQAVEELTEQLEQFKRAKANLDKNKQTLE 1230
Query: 68 TEQDEITLLLSLMKSSRNMNRSEKNYMELRLL-LQTK---------------EDYEALIK 111
E ++ L ++ ++ +K +E ++ LQ+K + ++
Sbjct: 1231 KENADLAGELRVLGQAKQEVEHKKKKLEAQVQELQSKCSDGERARAELNDKVHKLQNEVE 1290
Query: 112 SLKVLLAELDEKILQMEKKIANQKQIFAKMQEANNPRKLQK-----QIHILETRLNLVTV 166
S+ +L E + K +++ K +A+ QE QK ++ LE N +
Sbjct: 1291 SVTGMLNEAEGKAIKLAKDVASLSSQLQDTQELLQEETRQKLNVSTKLRQLEEERNSLQD 1350
Query: 167 HFDKMLTTNAKLRKEIEDLRFEKAAYDNVYQQLQ---HCLLMEKKTMNLAIEQSSQAYEQ 223
D+ + L + I L + + Q L KK IE +Q YE+
Sbjct: 1351 QLDEEMEAKQNLERHISTLNIQLSDSKKKLQDFASTVEALEEGKKRFQKEIENLTQQYEE 1410
Query: 224 RVEAMARMAAMK--------------DRQKKDTSQYNLEIRELERLYAHESKLKSFLLVK 269
+ A ++ K D Q++ S + R+ ++L A E + S
Sbjct: 1411 KAAAYDKLEKTKNRLQQELDDLVVDLDNQRQLVSNLEKKQRKFDQLLAEEKNISS-KYAD 1469
Query: 270 LNDRNEFEEQAKR----------EEALKAKKHVKKNRGESFESYEVAHLRLLKLAESGNL 319
DR E E + K EEAL+AK+ ++ R E+ L K N+
Sbjct: 1470 ERDRAEAEAREKETKALSLARALEEALEAKEELE--RTNKMLKAEMEDLVSSKDDVGKNV 1527
Query: 320 NQLIEDFLAKEEKNFARFTYVTELNNDMEMMHKRTQRIQDEIILLRSQQKLSHDDNHSVL 379
++L + A E + T + EL ++++ R++ + L+ Q D +
Sbjct: 1528 HELEKSKRALETQMEEMKTQLEELEDELQATEDAKLRLEVNMQALKGQ---FERDLQARD 1584
Query: 380 RQLEDKLRKTTEEADMYESKYGEVSKTLDLLKNSVEKL 417
Q E+K R+ + YE++ + K L + +KL
Sbjct: 1585 EQNEEKRRQLQRQLHEYETELEDERKQRALAAAAKKKL 1622
Score = 50.1 bits (118), Expect = 6e-06
Identities = 103/533 (19%), Positives = 217/533 (40%), Gaps = 112/533 (21%)
Query: 14 TPQEPSEKAKEQQAEAELRKLRQQFRKMVESRKSFKFRNQQKIASQYKEIKTLKTEQDEI 73
T QE +AKE EL+K +++ QQK ++ KE++ ++ E
Sbjct: 848 TRQEEEMQAKED----ELQKTKER---------------QQKAENELKELEQKHSQLTEE 888
Query: 74 TLLLSLMKSSRNMNRSEKNYMELRLLLQTKEDYEALIKSLKVLLAELDEKILQM------ 127
LL + +E M +RL + K++ E ++ ++ L E +++ Q+
Sbjct: 889 KNLLQEQLQAETELYAEAEEMRVRLAAK-KQELEEILHEMEARLEEEEDRGQQLQAERKK 947
Query: 128 -------------EKKIANQKQIFAKMQEANNPRKLQKQIHILETRLN-------LVTVH 167
E++ A QK K+ +KL+ +I +++ + N L+
Sbjct: 948 MAQQMLDLEEQLEEEEAARQKLQLEKVTAEAKIKKLEDEILVMDDQNNKLSKERKLLEER 1007
Query: 168 FDKMLTTNAKLRKEIEDLRFEKAAYDNVYQQLQHCLLMEKKT------MNLAIE-QSSQA 220
+ T A+ ++ ++L K ++++ +L+ L E+K+ + +E +S
Sbjct: 1008 ISDLTTNLAEEEEKAKNLTKLKNKHESMISELEVRLKKEEKSRQELEKLKRKLEGDASDF 1067
Query: 221 YEQRVEAMARMAAMKDRQKK--------------DTSQYNLEIRELERLYAHESKLKSFL 266
+EQ + A++A +K + K + +Q N ++++ L H S L+ L
Sbjct: 1068 HEQIADLQAQIAELKMQLAKKEEELQAALARLDDEIAQKNNALKKIRELEGHISDLQEDL 1127
Query: 267 LVKLNDRNEFEEQAK---------------------REEALKAKKH-----VKKNRGESF 300
+ RN+ E+Q + ++ L+AK+ +KK E
Sbjct: 1128 DSERAARNKAEKQKRDLGEELEALKTELEDTLDSTATQQELRAKREQEVTVLKKALDEET 1187
Query: 301 ESYE--VAHLRLLKLAESGNLNQLIEDFLAKEEKNFARFTYVTELNNDMEMMHKRTQRIQ 358
S+E V +R L + +E F K K L+ + + + K +
Sbjct: 1188 RSHEAQVQEMRQKHAQAVEELTEQLEQF--KRAK--------ANLDKNKQTLEKENADLA 1237
Query: 359 DEI-ILLRSQQKLSHDDNHSVLRQLEDKLRKTTEEADMYESKYGEVSKTLDLLKNSVEKL 417
E+ +L +++Q++ H ++LE ++++ + E E++ + L+N VE +
Sbjct: 1238 GELRVLGQAKQEVEHKK-----KKLEAQVQELQSKCSDGERARAELNDKVHKLQNEVESV 1292
Query: 418 FKKINCDATKILVQLGETGKVTDINLPQYFAIIEKKTNDLLLLETYRRILEVE 470
+N +A ++L + L +++++T L + T R LE E
Sbjct: 1293 TGMLN-EAEGKAIKLAKDVASLSSQLQDTQELLQEETRQKLNVSTKLRQLEEE 1344
>gi|92091586 smooth muscle myosin heavy chain 11 isoform SM1B [Homo
sapiens]
Length = 1979
Score = 59.7 bits (143), Expect = 7e-09
Identities = 108/483 (22%), Positives = 202/483 (41%), Gaps = 38/483 (7%)
Query: 6 KNRRKDSDTPQEPSEKAKEQQAEAELRKLRQQFRKMVESRKSFKFRNQQKIASQYKEIKT 65
K ++ ++ + S+ + ++A AEL + + VES + K K++ +
Sbjct: 1260 KKKKLEAQVQELQSKCSDGERARAELNDKVHKLQNEVESVTGMLNEAEGKAIKLAKDVAS 1319
Query: 66 LKTE-QDEITLLLSLMKSSRNMNRSEKNYMELRLLLQTKEDYEALIK-SLKVLLAELDEK 123
L ++ QD LL + N++ + E R LQ + D E K +L+ ++ L+ +
Sbjct: 1320 LSSQLQDTQELLQEETRQKLNVSTKLRQLEEERNSLQDQLDEEMEAKQNLERHISTLNIQ 1379
Query: 124 ILQMEKKIANQKQIFAKMQEA--NNPRKLQKQIHILETRLNLVTVHFDKMLTTNAKLRKE 181
+ +KK+ Q FA EA ++ QK+I L + +DK+ T +L++E
Sbjct: 1380 LSDSKKKL----QDFASTVEALEEGKKRFQKEIENLTQQYEEKAAAYDKLEKTKNRLQQE 1435
Query: 182 IEDLRFEKAAYDNVYQQLQHCLLMEKKTMNLAIEQS--SQAY---EQRVEAMARMAAMKD 236
++DL + DN Q + + ++K L E+ S Y R EA AR K
Sbjct: 1436 LDDLVVD---LDNQRQLVSNLEKKQRKFDQLLAEEKNISSKYADERDRAEAEAREKETKA 1492
Query: 237 RQKKDTSQYNLEIR-ELERLYAH-ESKLKSFLLVKLNDRNEFEEQAKREEALKAKKHVKK 294
+ LE + ELER +++++ + K + E K + AL+ + K
Sbjct: 1493 LSLARALEEALEAKEELERTNKMLKAEMEDLVSSKDDVGKNVHELEKSKRALETQMEEMK 1552
Query: 295 NRGESFE----SYEVAHLRLLKLAESGNLNQLIEDFLAKEEKNFARFTYVTELNNDMEMM 350
+ E E + E A LR L++ Q D A++E+N + + +
Sbjct: 1553 TQLEELEDELQATEDAKLR-LEVNMQALKGQFERDLQARDEQNEEKRRQL------QRQL 1605
Query: 351 HKRTQRIQDEIILLRSQQKLSHDDNHSVLRQLEDKLRKTTEEADMYESKYGEVSKTLDLL 410
H+ ++DE R Q+ L+ + ++LE L+ +AD E K L L
Sbjct: 1606 HEYETELEDE----RKQRALA----AAAKKKLEGDLKDLELQADSAIKGREEAIKQLRKL 1657
Query: 411 KNSVEKLFKKINCDATKILVQLGETGKVTDINLPQYFAIIEKKTNDLLLLETYRRILEVE 470
+ ++ +++ DA ++ T K + A + + DL E R+ ++E
Sbjct: 1658 QAQMKDFQRELE-DARASRDEIFATAKENEKKAKSLEADLMQLQEDLAAAERARKQADLE 1716
Query: 471 GAE 473
E
Sbjct: 1717 KEE 1719
Score = 57.8 bits (138), Expect = 3e-08
Identities = 94/427 (22%), Positives = 188/427 (44%), Gaps = 47/427 (11%)
Query: 6 KNRRKDSDTPQEPSEKAKEQQAEAELRKLRQQFRKMVESRKSFKFRNQQKIASQYKEIKT 65
K + ++ + + +E AK + E ++ L+ QF + +++R +N++K +++
Sbjct: 1552 KTQLEELEDELQATEDAK-LRLEVNMQALKGQFERDLQARDE---QNEEKRRQLQRQLHE 1607
Query: 66 LKTEQDEITLLLSLMKSSRNMNRSEKNYMELRLLLQTKEDYEALIKSLKVLLAELDEKIL 125
+TE ++ +L +++ + +EL+ K EA IK L+ L A++ +
Sbjct: 1608 YETELEDERKQRALAAAAKKKLEGDLKDLELQADSAIKGREEA-IKQLRKLQAQMKDFQR 1666
Query: 126 QMEKKIANQKQIFAKMQEANNPRKLQKQIHILETRLNLVTVHFDKMLTTNAKLRKEIEDL 185
++E A++ +IFA +E +K+ LE L + + L + RK+ DL
Sbjct: 1667 ELEDARASRDEIFATAKEN------EKKAKSLEADL----MQLQEDLAAAERARKQA-DL 1715
Query: 186 RFEKAAYDNVYQQL--QHCLLMEKKTMNLAIEQSSQAYEQRVEAMARMAAMKDRQKKDTS 243
E+ A + + L ++ L EK+ + I Q + E E M AM DR +K T
Sbjct: 1716 EKEELA-EELASSLSGRNALQDEKRRLEARIAQLEEELE---EEQGNMEAMSDRVRKATQ 1771
Query: 244 QYNLEIREL--ERLYAHESKLKSFLLVKLNDRNEFEEQAKREEALKAKKHVKKNRGESFE 301
Q EL ER A +++ + R + E Q K L++K H + +S
Sbjct: 1772 QAEQLSNELATERSTAQKNE---------SARQQLERQNKE---LRSKLHEMEGAVKSKF 1819
Query: 302 SYEVAHLRLLKLAESGNLNQLIEDFLAKEEKNFARFTYVTELNNDMEMMHKRTQRIQDEI 361
+A L A+ L + +E EK A L + + + +++DE
Sbjct: 1820 KSTIAALE----AKIAQLEEQVEQ--EAREKQAA----TKSLKQKDKKLKEILLQVEDER 1869
Query: 362 ILLRSQQKLSHDDNHSVLRQLEDKLRKTTEEADMYESKYGEVSKTLDLLKNSVEKLFKKI 421
+ Q K + ++ ++QL+ +L + EE+ + ++ + LD S E + +++
Sbjct: 1870 -KMAEQYKEQAEKGNARVKQLKRQLEEAEEESQRINANRRKLQRELDEATESNEAMGREV 1928
Query: 422 NCDATKI 428
N +K+
Sbjct: 1929 NALKSKL 1935
Score = 53.9 bits (128), Expect = 4e-07
Identities = 91/458 (19%), Positives = 181/458 (39%), Gaps = 54/458 (11%)
Query: 8 RRKDSDTPQEPSEKAKEQQAEAELRKLRQQFRKMVESRKSFKFRNQQKIASQYKEIKTLK 67
+R+ T + + + + EA+++++RQ+ + VE + ++ A+ K +TL+
Sbjct: 1178 KREQEVTVLKKALDEETRSHEAQVQEMRQKHAQAVEELTEQLEQFKRAKANLDKNKQTLE 1237
Query: 68 TEQDEITLLLSLMKSSRNMNRSEKNYMELRLL-LQTK---------------EDYEALIK 111
E ++ L ++ ++ +K +E ++ LQ+K + ++
Sbjct: 1238 KENADLAGELRVLGQAKQEVEHKKKKLEAQVQELQSKCSDGERARAELNDKVHKLQNEVE 1297
Query: 112 SLKVLLAELDEKILQMEKKIANQKQIFAKMQEANNPRKLQK-----QIHILETRLNLVTV 166
S+ +L E + K +++ K +A+ QE QK ++ LE N +
Sbjct: 1298 SVTGMLNEAEGKAIKLAKDVASLSSQLQDTQELLQEETRQKLNVSTKLRQLEEERNSLQD 1357
Query: 167 HFDKMLTTNAKLRKEIEDLRFEKAAYDNVYQQLQ---HCLLMEKKTMNLAIEQSSQAYEQ 223
D+ + L + I L + + Q L KK IE +Q YE+
Sbjct: 1358 QLDEEMEAKQNLERHISTLNIQLSDSKKKLQDFASTVEALEEGKKRFQKEIENLTQQYEE 1417
Query: 224 RVEAMARMAAMK--------------DRQKKDTSQYNLEIRELERLYAHESKLKSFLLVK 269
+ A ++ K D Q++ S + R+ ++L A E + S
Sbjct: 1418 KAAAYDKLEKTKNRLQQELDDLVVDLDNQRQLVSNLEKKQRKFDQLLAEEKNISS-KYAD 1476
Query: 270 LNDRNEFEEQAKR----------EEALKAKKHVKKNRGESFESYEVAHLRLLKLAESGNL 319
DR E E + K EEAL+AK+ ++ R E+ L K N+
Sbjct: 1477 ERDRAEAEAREKETKALSLARALEEALEAKEELE--RTNKMLKAEMEDLVSSKDDVGKNV 1534
Query: 320 NQLIEDFLAKEEKNFARFTYVTELNNDMEMMHKRTQRIQDEIILLRSQQKLSHDDNHSVL 379
++L + A E + T + EL ++++ R++ + L+ Q D +
Sbjct: 1535 HELEKSKRALETQMEEMKTQLEELEDELQATEDAKLRLEVNMQALKGQ---FERDLQARD 1591
Query: 380 RQLEDKLRKTTEEADMYESKYGEVSKTLDLLKNSVEKL 417
Q E+K R+ + YE++ + K L + +KL
Sbjct: 1592 EQNEEKRRQLQRQLHEYETELEDERKQRALAAAAKKKL 1629
Score = 50.1 bits (118), Expect = 6e-06
Identities = 103/533 (19%), Positives = 217/533 (40%), Gaps = 112/533 (21%)
Query: 14 TPQEPSEKAKEQQAEAELRKLRQQFRKMVESRKSFKFRNQQKIASQYKEIKTLKTEQDEI 73
T QE +AKE EL+K +++ QQK ++ KE++ ++ E
Sbjct: 855 TRQEEEMQAKED----ELQKTKER---------------QQKAENELKELEQKHSQLTEE 895
Query: 74 TLLLSLMKSSRNMNRSEKNYMELRLLLQTKEDYEALIKSLKVLLAELDEKILQM------ 127
LL + +E M +RL + K++ E ++ ++ L E +++ Q+
Sbjct: 896 KNLLQEQLQAETELYAEAEEMRVRLAAK-KQELEEILHEMEARLEEEEDRGQQLQAERKK 954
Query: 128 -------------EKKIANQKQIFAKMQEANNPRKLQKQIHILETRLN-------LVTVH 167
E++ A QK K+ +KL+ +I +++ + N L+
Sbjct: 955 MAQQMLDLEEQLEEEEAARQKLQLEKVTAEAKIKKLEDEILVMDDQNNKLSKERKLLEER 1014
Query: 168 FDKMLTTNAKLRKEIEDLRFEKAAYDNVYQQLQHCLLMEKKT------MNLAIE-QSSQA 220
+ T A+ ++ ++L K ++++ +L+ L E+K+ + +E +S
Sbjct: 1015 ISDLTTNLAEEEEKAKNLTKLKNKHESMISELEVRLKKEEKSRQELEKLKRKLEGDASDF 1074
Query: 221 YEQRVEAMARMAAMKDRQKK--------------DTSQYNLEIRELERLYAHESKLKSFL 266
+EQ + A++A +K + K + +Q N ++++ L H S L+ L
Sbjct: 1075 HEQIADLQAQIAELKMQLAKKEEELQAALARLDDEIAQKNNALKKIRELEGHISDLQEDL 1134
Query: 267 LVKLNDRNEFEEQAK---------------------REEALKAKKH-----VKKNRGESF 300
+ RN+ E+Q + ++ L+AK+ +KK E
Sbjct: 1135 DSERAARNKAEKQKRDLGEELEALKTELEDTLDSTATQQELRAKREQEVTVLKKALDEET 1194
Query: 301 ESYE--VAHLRLLKLAESGNLNQLIEDFLAKEEKNFARFTYVTELNNDMEMMHKRTQRIQ 358
S+E V +R L + +E F K K L+ + + + K +
Sbjct: 1195 RSHEAQVQEMRQKHAQAVEELTEQLEQF--KRAK--------ANLDKNKQTLEKENADLA 1244
Query: 359 DEI-ILLRSQQKLSHDDNHSVLRQLEDKLRKTTEEADMYESKYGEVSKTLDLLKNSVEKL 417
E+ +L +++Q++ H ++LE ++++ + E E++ + L+N VE +
Sbjct: 1245 GELRVLGQAKQEVEHKK-----KKLEAQVQELQSKCSDGERARAELNDKVHKLQNEVESV 1299
Query: 418 FKKINCDATKILVQLGETGKVTDINLPQYFAIIEKKTNDLLLLETYRRILEVE 470
+N +A ++L + L +++++T L + T R LE E
Sbjct: 1300 TGMLN-EAEGKAIKLAKDVASLSSQLQDTQELLQEETRQKLNVSTKLRQLEEE 1351
>gi|92091583 smooth muscle myosin heavy chain 11 isoform SM2B [Homo
sapiens]
Length = 1945
Score = 59.7 bits (143), Expect = 7e-09
Identities = 108/483 (22%), Positives = 202/483 (41%), Gaps = 38/483 (7%)
Query: 6 KNRRKDSDTPQEPSEKAKEQQAEAELRKLRQQFRKMVESRKSFKFRNQQKIASQYKEIKT 65
K ++ ++ + S+ + ++A AEL + + VES + K K++ +
Sbjct: 1260 KKKKLEAQVQELQSKCSDGERARAELNDKVHKLQNEVESVTGMLNEAEGKAIKLAKDVAS 1319
Query: 66 LKTE-QDEITLLLSLMKSSRNMNRSEKNYMELRLLLQTKEDYEALIK-SLKVLLAELDEK 123
L ++ QD LL + N++ + E R LQ + D E K +L+ ++ L+ +
Sbjct: 1320 LSSQLQDTQELLQEETRQKLNVSTKLRQLEEERNSLQDQLDEEMEAKQNLERHISTLNIQ 1379
Query: 124 ILQMEKKIANQKQIFAKMQEA--NNPRKLQKQIHILETRLNLVTVHFDKMLTTNAKLRKE 181
+ +KK+ Q FA EA ++ QK+I L + +DK+ T +L++E
Sbjct: 1380 LSDSKKKL----QDFASTVEALEEGKKRFQKEIENLTQQYEEKAAAYDKLEKTKNRLQQE 1435
Query: 182 IEDLRFEKAAYDNVYQQLQHCLLMEKKTMNLAIEQS--SQAY---EQRVEAMARMAAMKD 236
++DL + DN Q + + ++K L E+ S Y R EA AR K
Sbjct: 1436 LDDLVVD---LDNQRQLVSNLEKKQRKFDQLLAEEKNISSKYADERDRAEAEAREKETKA 1492
Query: 237 RQKKDTSQYNLEIR-ELERLYAH-ESKLKSFLLVKLNDRNEFEEQAKREEALKAKKHVKK 294
+ LE + ELER +++++ + K + E K + AL+ + K
Sbjct: 1493 LSLARALEEALEAKEELERTNKMLKAEMEDLVSSKDDVGKNVHELEKSKRALETQMEEMK 1552
Query: 295 NRGESFE----SYEVAHLRLLKLAESGNLNQLIEDFLAKEEKNFARFTYVTELNNDMEMM 350
+ E E + E A LR L++ Q D A++E+N + + +
Sbjct: 1553 TQLEELEDELQATEDAKLR-LEVNMQALKGQFERDLQARDEQNEEKRRQL------QRQL 1605
Query: 351 HKRTQRIQDEIILLRSQQKLSHDDNHSVLRQLEDKLRKTTEEADMYESKYGEVSKTLDLL 410
H+ ++DE R Q+ L+ + ++LE L+ +AD E K L L
Sbjct: 1606 HEYETELEDE----RKQRALA----AAAKKKLEGDLKDLELQADSAIKGREEAIKQLRKL 1657
Query: 411 KNSVEKLFKKINCDATKILVQLGETGKVTDINLPQYFAIIEKKTNDLLLLETYRRILEVE 470
+ ++ +++ DA ++ T K + A + + DL E R+ ++E
Sbjct: 1658 QAQMKDFQRELE-DARASRDEIFATAKENEKKAKSLEADLMQLQEDLAAAERARKQADLE 1716
Query: 471 GAE 473
E
Sbjct: 1717 KEE 1719
Score = 57.8 bits (138), Expect = 3e-08
Identities = 94/427 (22%), Positives = 188/427 (44%), Gaps = 47/427 (11%)
Query: 6 KNRRKDSDTPQEPSEKAKEQQAEAELRKLRQQFRKMVESRKSFKFRNQQKIASQYKEIKT 65
K + ++ + + +E AK + E ++ L+ QF + +++R +N++K +++
Sbjct: 1552 KTQLEELEDELQATEDAK-LRLEVNMQALKGQFERDLQARDE---QNEEKRRQLQRQLHE 1607
Query: 66 LKTEQDEITLLLSLMKSSRNMNRSEKNYMELRLLLQTKEDYEALIKSLKVLLAELDEKIL 125
+TE ++ +L +++ + +EL+ K EA IK L+ L A++ +
Sbjct: 1608 YETELEDERKQRALAAAAKKKLEGDLKDLELQADSAIKGREEA-IKQLRKLQAQMKDFQR 1666
Query: 126 QMEKKIANQKQIFAKMQEANNPRKLQKQIHILETRLNLVTVHFDKMLTTNAKLRKEIEDL 185
++E A++ +IFA +E +K+ LE L + + L + RK+ DL
Sbjct: 1667 ELEDARASRDEIFATAKEN------EKKAKSLEADL----MQLQEDLAAAERARKQA-DL 1715
Query: 186 RFEKAAYDNVYQQL--QHCLLMEKKTMNLAIEQSSQAYEQRVEAMARMAAMKDRQKKDTS 243
E+ A + + L ++ L EK+ + I Q + E E M AM DR +K T
Sbjct: 1716 EKEELA-EELASSLSGRNALQDEKRRLEARIAQLEEELE---EEQGNMEAMSDRVRKATQ 1771
Query: 244 QYNLEIREL--ERLYAHESKLKSFLLVKLNDRNEFEEQAKREEALKAKKHVKKNRGESFE 301
Q EL ER A +++ + R + E Q K L++K H + +S
Sbjct: 1772 QAEQLSNELATERSTAQKNE---------SARQQLERQNKE---LRSKLHEMEGAVKSKF 1819
Query: 302 SYEVAHLRLLKLAESGNLNQLIEDFLAKEEKNFARFTYVTELNNDMEMMHKRTQRIQDEI 361
+A L A+ L + +E EK A L + + + +++DE
Sbjct: 1820 KSTIAALE----AKIAQLEEQVEQ--EAREKQAA----TKSLKQKDKKLKEILLQVEDER 1869
Query: 362 ILLRSQQKLSHDDNHSVLRQLEDKLRKTTEEADMYESKYGEVSKTLDLLKNSVEKLFKKI 421
+ Q K + ++ ++QL+ +L + EE+ + ++ + LD S E + +++
Sbjct: 1870 -KMAEQYKEQAEKGNARVKQLKRQLEEAEEESQRINANRRKLQRELDEATESNEAMGREV 1928
Query: 422 NCDATKI 428
N +K+
Sbjct: 1929 NALKSKL 1935
Score = 53.9 bits (128), Expect = 4e-07
Identities = 91/458 (19%), Positives = 181/458 (39%), Gaps = 54/458 (11%)
Query: 8 RRKDSDTPQEPSEKAKEQQAEAELRKLRQQFRKMVESRKSFKFRNQQKIASQYKEIKTLK 67
+R+ T + + + + EA+++++RQ+ + VE + ++ A+ K +TL+
Sbjct: 1178 KREQEVTVLKKALDEETRSHEAQVQEMRQKHAQAVEELTEQLEQFKRAKANLDKNKQTLE 1237
Query: 68 TEQDEITLLLSLMKSSRNMNRSEKNYMELRLL-LQTK---------------EDYEALIK 111
E ++ L ++ ++ +K +E ++ LQ+K + ++
Sbjct: 1238 KENADLAGELRVLGQAKQEVEHKKKKLEAQVQELQSKCSDGERARAELNDKVHKLQNEVE 1297
Query: 112 SLKVLLAELDEKILQMEKKIANQKQIFAKMQEANNPRKLQK-----QIHILETRLNLVTV 166
S+ +L E + K +++ K +A+ QE QK ++ LE N +
Sbjct: 1298 SVTGMLNEAEGKAIKLAKDVASLSSQLQDTQELLQEETRQKLNVSTKLRQLEEERNSLQD 1357
Query: 167 HFDKMLTTNAKLRKEIEDLRFEKAAYDNVYQQLQ---HCLLMEKKTMNLAIEQSSQAYEQ 223
D+ + L + I L + + Q L KK IE +Q YE+
Sbjct: 1358 QLDEEMEAKQNLERHISTLNIQLSDSKKKLQDFASTVEALEEGKKRFQKEIENLTQQYEE 1417
Query: 224 RVEAMARMAAMK--------------DRQKKDTSQYNLEIRELERLYAHESKLKSFLLVK 269
+ A ++ K D Q++ S + R+ ++L A E + S
Sbjct: 1418 KAAAYDKLEKTKNRLQQELDDLVVDLDNQRQLVSNLEKKQRKFDQLLAEEKNISS-KYAD 1476
Query: 270 LNDRNEFEEQAKR----------EEALKAKKHVKKNRGESFESYEVAHLRLLKLAESGNL 319
DR E E + K EEAL+AK+ ++ R E+ L K N+
Sbjct: 1477 ERDRAEAEAREKETKALSLARALEEALEAKEELE--RTNKMLKAEMEDLVSSKDDVGKNV 1534
Query: 320 NQLIEDFLAKEEKNFARFTYVTELNNDMEMMHKRTQRIQDEIILLRSQQKLSHDDNHSVL 379
++L + A E + T + EL ++++ R++ + L+ Q D +
Sbjct: 1535 HELEKSKRALETQMEEMKTQLEELEDELQATEDAKLRLEVNMQALKGQ---FERDLQARD 1591
Query: 380 RQLEDKLRKTTEEADMYESKYGEVSKTLDLLKNSVEKL 417
Q E+K R+ + YE++ + K L + +KL
Sbjct: 1592 EQNEEKRRQLQRQLHEYETELEDERKQRALAAAAKKKL 1629
Score = 50.1 bits (118), Expect = 6e-06
Identities = 103/533 (19%), Positives = 217/533 (40%), Gaps = 112/533 (21%)
Query: 14 TPQEPSEKAKEQQAEAELRKLRQQFRKMVESRKSFKFRNQQKIASQYKEIKTLKTEQDEI 73
T QE +AKE EL+K +++ QQK ++ KE++ ++ E
Sbjct: 855 TRQEEEMQAKED----ELQKTKER---------------QQKAENELKELEQKHSQLTEE 895
Query: 74 TLLLSLMKSSRNMNRSEKNYMELRLLLQTKEDYEALIKSLKVLLAELDEKILQM------ 127
LL + +E M +RL + K++ E ++ ++ L E +++ Q+
Sbjct: 896 KNLLQEQLQAETELYAEAEEMRVRLAAK-KQELEEILHEMEARLEEEEDRGQQLQAERKK 954
Query: 128 -------------EKKIANQKQIFAKMQEANNPRKLQKQIHILETRLN-------LVTVH 167
E++ A QK K+ +KL+ +I +++ + N L+
Sbjct: 955 MAQQMLDLEEQLEEEEAARQKLQLEKVTAEAKIKKLEDEILVMDDQNNKLSKERKLLEER 1014
Query: 168 FDKMLTTNAKLRKEIEDLRFEKAAYDNVYQQLQHCLLMEKKT------MNLAIE-QSSQA 220
+ T A+ ++ ++L K ++++ +L+ L E+K+ + +E +S
Sbjct: 1015 ISDLTTNLAEEEEKAKNLTKLKNKHESMISELEVRLKKEEKSRQELEKLKRKLEGDASDF 1074
Query: 221 YEQRVEAMARMAAMKDRQKK--------------DTSQYNLEIRELERLYAHESKLKSFL 266
+EQ + A++A +K + K + +Q N ++++ L H S L+ L
Sbjct: 1075 HEQIADLQAQIAELKMQLAKKEEELQAALARLDDEIAQKNNALKKIRELEGHISDLQEDL 1134
Query: 267 LVKLNDRNEFEEQAK---------------------REEALKAKKH-----VKKNRGESF 300
+ RN+ E+Q + ++ L+AK+ +KK E
Sbjct: 1135 DSERAARNKAEKQKRDLGEELEALKTELEDTLDSTATQQELRAKREQEVTVLKKALDEET 1194
Query: 301 ESYE--VAHLRLLKLAESGNLNQLIEDFLAKEEKNFARFTYVTELNNDMEMMHKRTQRIQ 358
S+E V +R L + +E F K K L+ + + + K +
Sbjct: 1195 RSHEAQVQEMRQKHAQAVEELTEQLEQF--KRAK--------ANLDKNKQTLEKENADLA 1244
Query: 359 DEI-ILLRSQQKLSHDDNHSVLRQLEDKLRKTTEEADMYESKYGEVSKTLDLLKNSVEKL 417
E+ +L +++Q++ H ++LE ++++ + E E++ + L+N VE +
Sbjct: 1245 GELRVLGQAKQEVEHKK-----KKLEAQVQELQSKCSDGERARAELNDKVHKLQNEVESV 1299
Query: 418 FKKINCDATKILVQLGETGKVTDINLPQYFAIIEKKTNDLLLLETYRRILEVE 470
+N +A ++L + L +++++T L + T R LE E
Sbjct: 1300 TGMLN-EAEGKAIKLAKDVASLSSQLQDTQELLQEETRQKLNVSTKLRQLEEE 1351
>gi|13124875 smooth muscle myosin heavy chain 11 isoform SM2A [Homo
sapiens]
Length = 1938
Score = 59.7 bits (143), Expect = 7e-09
Identities = 108/483 (22%), Positives = 202/483 (41%), Gaps = 38/483 (7%)
Query: 6 KNRRKDSDTPQEPSEKAKEQQAEAELRKLRQQFRKMVESRKSFKFRNQQKIASQYKEIKT 65
K ++ ++ + S+ + ++A AEL + + VES + K K++ +
Sbjct: 1253 KKKKLEAQVQELQSKCSDGERARAELNDKVHKLQNEVESVTGMLNEAEGKAIKLAKDVAS 1312
Query: 66 LKTE-QDEITLLLSLMKSSRNMNRSEKNYMELRLLLQTKEDYEALIK-SLKVLLAELDEK 123
L ++ QD LL + N++ + E R LQ + D E K +L+ ++ L+ +
Sbjct: 1313 LSSQLQDTQELLQEETRQKLNVSTKLRQLEEERNSLQDQLDEEMEAKQNLERHISTLNIQ 1372
Query: 124 ILQMEKKIANQKQIFAKMQEA--NNPRKLQKQIHILETRLNLVTVHFDKMLTTNAKLRKE 181
+ +KK+ Q FA EA ++ QK+I L + +DK+ T +L++E
Sbjct: 1373 LSDSKKKL----QDFASTVEALEEGKKRFQKEIENLTQQYEEKAAAYDKLEKTKNRLQQE 1428
Query: 182 IEDLRFEKAAYDNVYQQLQHCLLMEKKTMNLAIEQS--SQAY---EQRVEAMARMAAMKD 236
++DL + DN Q + + ++K L E+ S Y R EA AR K
Sbjct: 1429 LDDLVVD---LDNQRQLVSNLEKKQRKFDQLLAEEKNISSKYADERDRAEAEAREKETKA 1485
Query: 237 RQKKDTSQYNLEIR-ELERLYAH-ESKLKSFLLVKLNDRNEFEEQAKREEALKAKKHVKK 294
+ LE + ELER +++++ + K + E K + AL+ + K
Sbjct: 1486 LSLARALEEALEAKEELERTNKMLKAEMEDLVSSKDDVGKNVHELEKSKRALETQMEEMK 1545
Query: 295 NRGESFE----SYEVAHLRLLKLAESGNLNQLIEDFLAKEEKNFARFTYVTELNNDMEMM 350
+ E E + E A LR L++ Q D A++E+N + + +
Sbjct: 1546 TQLEELEDELQATEDAKLR-LEVNMQALKGQFERDLQARDEQNEEKRRQL------QRQL 1598
Query: 351 HKRTQRIQDEIILLRSQQKLSHDDNHSVLRQLEDKLRKTTEEADMYESKYGEVSKTLDLL 410
H+ ++DE R Q+ L+ + ++LE L+ +AD E K L L
Sbjct: 1599 HEYETELEDE----RKQRALA----AAAKKKLEGDLKDLELQADSAIKGREEAIKQLRKL 1650
Query: 411 KNSVEKLFKKINCDATKILVQLGETGKVTDINLPQYFAIIEKKTNDLLLLETYRRILEVE 470
+ ++ +++ DA ++ T K + A + + DL E R+ ++E
Sbjct: 1651 QAQMKDFQRELE-DARASRDEIFATAKENEKKAKSLEADLMQLQEDLAAAERARKQADLE 1709
Query: 471 GAE 473
E
Sbjct: 1710 KEE 1712
Score = 57.8 bits (138), Expect = 3e-08
Identities = 94/427 (22%), Positives = 188/427 (44%), Gaps = 47/427 (11%)
Query: 6 KNRRKDSDTPQEPSEKAKEQQAEAELRKLRQQFRKMVESRKSFKFRNQQKIASQYKEIKT 65
K + ++ + + +E AK + E ++ L+ QF + +++R +N++K +++
Sbjct: 1545 KTQLEELEDELQATEDAK-LRLEVNMQALKGQFERDLQARDE---QNEEKRRQLQRQLHE 1600
Query: 66 LKTEQDEITLLLSLMKSSRNMNRSEKNYMELRLLLQTKEDYEALIKSLKVLLAELDEKIL 125
+TE ++ +L +++ + +EL+ K EA IK L+ L A++ +
Sbjct: 1601 YETELEDERKQRALAAAAKKKLEGDLKDLELQADSAIKGREEA-IKQLRKLQAQMKDFQR 1659
Query: 126 QMEKKIANQKQIFAKMQEANNPRKLQKQIHILETRLNLVTVHFDKMLTTNAKLRKEIEDL 185
++E A++ +IFA +E +K+ LE L + + L + RK+ DL
Sbjct: 1660 ELEDARASRDEIFATAKEN------EKKAKSLEADL----MQLQEDLAAAERARKQA-DL 1708
Query: 186 RFEKAAYDNVYQQL--QHCLLMEKKTMNLAIEQSSQAYEQRVEAMARMAAMKDRQKKDTS 243
E+ A + + L ++ L EK+ + I Q + E E M AM DR +K T
Sbjct: 1709 EKEELA-EELASSLSGRNALQDEKRRLEARIAQLEEELE---EEQGNMEAMSDRVRKATQ 1764
Query: 244 QYNLEIREL--ERLYAHESKLKSFLLVKLNDRNEFEEQAKREEALKAKKHVKKNRGESFE 301
Q EL ER A +++ + R + E Q K L++K H + +S
Sbjct: 1765 QAEQLSNELATERSTAQKNE---------SARQQLERQNKE---LRSKLHEMEGAVKSKF 1812
Query: 302 SYEVAHLRLLKLAESGNLNQLIEDFLAKEEKNFARFTYVTELNNDMEMMHKRTQRIQDEI 361
+A L A+ L + +E EK A L + + + +++DE
Sbjct: 1813 KSTIAALE----AKIAQLEEQVEQ--EAREKQAA----TKSLKQKDKKLKEILLQVEDER 1862
Query: 362 ILLRSQQKLSHDDNHSVLRQLEDKLRKTTEEADMYESKYGEVSKTLDLLKNSVEKLFKKI 421
+ Q K + ++ ++QL+ +L + EE+ + ++ + LD S E + +++
Sbjct: 1863 -KMAEQYKEQAEKGNARVKQLKRQLEEAEEESQRINANRRKLQRELDEATESNEAMGREV 1921
Query: 422 NCDATKI 428
N +K+
Sbjct: 1922 NALKSKL 1928
Score = 53.9 bits (128), Expect = 4e-07
Identities = 91/458 (19%), Positives = 181/458 (39%), Gaps = 54/458 (11%)
Query: 8 RRKDSDTPQEPSEKAKEQQAEAELRKLRQQFRKMVESRKSFKFRNQQKIASQYKEIKTLK 67
+R+ T + + + + EA+++++RQ+ + VE + ++ A+ K +TL+
Sbjct: 1171 KREQEVTVLKKALDEETRSHEAQVQEMRQKHAQAVEELTEQLEQFKRAKANLDKNKQTLE 1230
Query: 68 TEQDEITLLLSLMKSSRNMNRSEKNYMELRLL-LQTK---------------EDYEALIK 111
E ++ L ++ ++ +K +E ++ LQ+K + ++
Sbjct: 1231 KENADLAGELRVLGQAKQEVEHKKKKLEAQVQELQSKCSDGERARAELNDKVHKLQNEVE 1290
Query: 112 SLKVLLAELDEKILQMEKKIANQKQIFAKMQEANNPRKLQK-----QIHILETRLNLVTV 166
S+ +L E + K +++ K +A+ QE QK ++ LE N +
Sbjct: 1291 SVTGMLNEAEGKAIKLAKDVASLSSQLQDTQELLQEETRQKLNVSTKLRQLEEERNSLQD 1350
Query: 167 HFDKMLTTNAKLRKEIEDLRFEKAAYDNVYQQLQ---HCLLMEKKTMNLAIEQSSQAYEQ 223
D+ + L + I L + + Q L KK IE +Q YE+
Sbjct: 1351 QLDEEMEAKQNLERHISTLNIQLSDSKKKLQDFASTVEALEEGKKRFQKEIENLTQQYEE 1410
Query: 224 RVEAMARMAAMK--------------DRQKKDTSQYNLEIRELERLYAHESKLKSFLLVK 269
+ A ++ K D Q++ S + R+ ++L A E + S
Sbjct: 1411 KAAAYDKLEKTKNRLQQELDDLVVDLDNQRQLVSNLEKKQRKFDQLLAEEKNISS-KYAD 1469
Query: 270 LNDRNEFEEQAKR----------EEALKAKKHVKKNRGESFESYEVAHLRLLKLAESGNL 319
DR E E + K EEAL+AK+ ++ R E+ L K N+
Sbjct: 1470 ERDRAEAEAREKETKALSLARALEEALEAKEELE--RTNKMLKAEMEDLVSSKDDVGKNV 1527
Query: 320 NQLIEDFLAKEEKNFARFTYVTELNNDMEMMHKRTQRIQDEIILLRSQQKLSHDDNHSVL 379
++L + A E + T + EL ++++ R++ + L+ Q D +
Sbjct: 1528 HELEKSKRALETQMEEMKTQLEELEDELQATEDAKLRLEVNMQALKGQ---FERDLQARD 1584
Query: 380 RQLEDKLRKTTEEADMYESKYGEVSKTLDLLKNSVEKL 417
Q E+K R+ + YE++ + K L + +KL
Sbjct: 1585 EQNEEKRRQLQRQLHEYETELEDERKQRALAAAAKKKL 1622
Score = 50.1 bits (118), Expect = 6e-06
Identities = 103/533 (19%), Positives = 217/533 (40%), Gaps = 112/533 (21%)
Query: 14 TPQEPSEKAKEQQAEAELRKLRQQFRKMVESRKSFKFRNQQKIASQYKEIKTLKTEQDEI 73
T QE +AKE EL+K +++ QQK ++ KE++ ++ E
Sbjct: 848 TRQEEEMQAKED----ELQKTKER---------------QQKAENELKELEQKHSQLTEE 888
Query: 74 TLLLSLMKSSRNMNRSEKNYMELRLLLQTKEDYEALIKSLKVLLAELDEKILQM------ 127
LL + +E M +RL + K++ E ++ ++ L E +++ Q+
Sbjct: 889 KNLLQEQLQAETELYAEAEEMRVRLAAK-KQELEEILHEMEARLEEEEDRGQQLQAERKK 947
Query: 128 -------------EKKIANQKQIFAKMQEANNPRKLQKQIHILETRLN-------LVTVH 167
E++ A QK K+ +KL+ +I +++ + N L+
Sbjct: 948 MAQQMLDLEEQLEEEEAARQKLQLEKVTAEAKIKKLEDEILVMDDQNNKLSKERKLLEER 1007
Query: 168 FDKMLTTNAKLRKEIEDLRFEKAAYDNVYQQLQHCLLMEKKT------MNLAIE-QSSQA 220
+ T A+ ++ ++L K ++++ +L+ L E+K+ + +E +S
Sbjct: 1008 ISDLTTNLAEEEEKAKNLTKLKNKHESMISELEVRLKKEEKSRQELEKLKRKLEGDASDF 1067
Query: 221 YEQRVEAMARMAAMKDRQKK--------------DTSQYNLEIRELERLYAHESKLKSFL 266
+EQ + A++A +K + K + +Q N ++++ L H S L+ L
Sbjct: 1068 HEQIADLQAQIAELKMQLAKKEEELQAALARLDDEIAQKNNALKKIRELEGHISDLQEDL 1127
Query: 267 LVKLNDRNEFEEQAK---------------------REEALKAKKH-----VKKNRGESF 300
+ RN+ E+Q + ++ L+AK+ +KK E
Sbjct: 1128 DSERAARNKAEKQKRDLGEELEALKTELEDTLDSTATQQELRAKREQEVTVLKKALDEET 1187
Query: 301 ESYE--VAHLRLLKLAESGNLNQLIEDFLAKEEKNFARFTYVTELNNDMEMMHKRTQRIQ 358
S+E V +R L + +E F K K L+ + + + K +
Sbjct: 1188 RSHEAQVQEMRQKHAQAVEELTEQLEQF--KRAK--------ANLDKNKQTLEKENADLA 1237
Query: 359 DEI-ILLRSQQKLSHDDNHSVLRQLEDKLRKTTEEADMYESKYGEVSKTLDLLKNSVEKL 417
E+ +L +++Q++ H ++LE ++++ + E E++ + L+N VE +
Sbjct: 1238 GELRVLGQAKQEVEHKK-----KKLEAQVQELQSKCSDGERARAELNDKVHKLQNEVESV 1292
Query: 418 FKKINCDATKILVQLGETGKVTDINLPQYFAIIEKKTNDLLLLETYRRILEVE 470
+N +A ++L + L +++++T L + T R LE E
Sbjct: 1293 TGMLN-EAEGKAIKLAKDVASLSSQLQDTQELLQEETRQKLNVSTKLRQLEEE 1344
>gi|31982906 cingulin-like 1 [Homo sapiens]
Length = 1302
Score = 58.9 bits (141), Expect = 1e-08
Identities = 101/447 (22%), Positives = 192/447 (42%), Gaps = 85/447 (19%)
Query: 21 KAKEQQAEAELRKLRQQFRKMVESRKSFKFRNQQKIASQYKEIKTLKTEQDEITLLLSLM 80
K + +Q + E+R L+ Q +M + S K ++ + +E+ L+ +QD LL++
Sbjct: 690 KMEREQHQTEIRDLQDQLSEMHDELDSAKRSEDREKGALIEEL--LQAKQDLQDLLIAKE 747
Query: 81 KSSRNMNRSEKNYMELRLLLQT------------KEDYEALIKSLKVLLAELDE--KILQ 126
+ + + E+ L+ L+ KE Y+A +++L+ + E + ++L
Sbjct: 748 EQEDLLRKRERELTALKGALKEEVSSHDQEMDKLKEQYDAELQALRESVEEATKNVEVLA 807
Query: 127 MEKKIANQKQIFAKM-----QEANNPRKLQKQIHILETRLNLVTVHFDKMLTTNAKLRKE 181
+ Q Q +M QE N KLQ + LE R+ A+L+++
Sbjct: 808 SRSNTSEQDQAGTEMRVKLLQEENE--KLQGRSEELERRV--------------AQLQRQ 851
Query: 182 IEDLRFEKAA-------YDNVYQQLQHCLLMEKKTMNLAIEQSSQAYEQRVEAMARMAAM 234
IEDL+ ++A Y+ +QL+ L+ +K A+ + +A E +EA
Sbjct: 852 IEDLKGDEAKAKETLKKYEGEIRQLEEALVHARKEEKEAVS-ARRALENELEAA------ 904
Query: 235 KDRQKKDTSQYNLEIRELERLYAHESKLKSFLLVKLNDRNEFEEQAKREEALKAKKHVKK 294
+ + SQ E ++L ES+ K L +NE E + R K + ++K
Sbjct: 905 ----QGNLSQTTQEQKQLSEKLKEESEQKEQLR---RLKNEMENE--RWHLGKTIEKLQK 955
Query: 295 NRGESFESYEVAHLRL---LKLAESGNLNQLIEDFLAKEEKNF----ARFTYVTELNNDM 347
+ E+ + L L L + N +L E +EK +R T + ++ ++M
Sbjct: 956 EMADIVEASRTSTLELQNQLDEYKEKNRRELAEMQRQLKEKTLEAEKSRLTAM-KMQDEM 1014
Query: 348 EMMHKRT---QRIQDEIILLRS--QQKL----------SH--DDNHSVLRQLEDKLRKTT 390
+M + QR QDE + R +Q L SH DD +++Q+EDK+ +
Sbjct: 1015 RLMEEELRDYQRAQDEALTKRQLLEQTLKDLEYELEAKSHLKDDRSRLVKQMEDKVSQLE 1074
Query: 391 EEADMYESKYGEVSKTLDLLKNSVEKL 417
E + + +S+ + + +E+L
Sbjct: 1075 MELEEERNNSDLLSERISRSREQMEQL 1101
Score = 47.4 bits (111), Expect = 4e-05
Identities = 94/433 (21%), Positives = 178/433 (41%), Gaps = 62/433 (14%)
Query: 21 KAKE--QQAEAELRKL-------RQQFRKMVESRKSFKFR------NQQKIASQYKEIKT 65
KAKE ++ E E+R+L R++ ++ V +R++ + N + + K++
Sbjct: 861 KAKETLKKYEGEIRQLEEALVHARKEEKEAVSARRALENELEAAQGNLSQTTQEQKQLSE 920
Query: 66 LKTEQDEITLLLSLMKSSRNMNRSEKNYMELRLLLQTKEDYEALIKSLKVLLAELDEKIL 125
E+ E L +K+ R +L + + EA S L +LDE
Sbjct: 921 KLKEESEQKEQLRRLKNEMENERWHLGKTIEKLQKEMADIVEASRTSTLELQNQLDEYKE 980
Query: 126 QMEKKIAN-QKQIFAKMQEANNPR----KLQKQIHILETRLNLVTVHFDKMLTTNAKLRK 180
+ +++A Q+Q+ K EA R K+Q ++ ++E L D+ LT L +
Sbjct: 981 KNRRELAEMQRQLKEKTLEAEKSRLTAMKMQDEMRLMEEELRDYQRAQDEALTKRQLLEQ 1040
Query: 181 EIEDLRFEKAA--------------YDNVYQQLQHCLLMEKKTMNLAIEQSSQAYEQ--- 223
++DL +E A ++ QL+ L E+ +L E+ S++ EQ
Sbjct: 1041 TLKDLEYELEAKSHLKDDRSRLVKQMEDKVSQLEMELEEERNNSDLLSERISRSREQMEQ 1100
Query: 224 -RVEAMARMAAMKD---------RQKKDTSQYNLEIRELERLYAHESKLKSFLLVKLNDR 273
R E + AA +D RQ KD I LE Y K L+V++ R
Sbjct: 1101 LRNELLQERAARQDLECDKISLERQNKDLKS---RIIHLEGSYRSS---KEGLVVQMEAR 1154
Query: 274 -NEFEEQAKREEALKAKKHVKKNR-----GESFESYEVAHLRLLKLAESGNLN-QLIEDF 326
E E++ + EE +A + R E + HL L + +L + ++
Sbjct: 1155 IAELEDRLESEERDRANLQLSNRRLERKVKELVMQVDDEHLSLTDQKDQLSLRLKAMKRQ 1214
Query: 327 LAKEEKNFARF-TYVTELNNDMEMMHKRTQRIQDEIILLRSQQKLSHDDNHSVLRQLEDK 385
+ + E+ R + +L ++E + +Q ++ ++ +L + VL ++D
Sbjct: 1215 VEEAEEEIDRLESSKKKLQRELEEQMDMNEHLQGQLNSMKKDLRLKKLPS-KVLDDMDDD 1273
Query: 386 LRKTTEEADMYES 398
+T+ +YE+
Sbjct: 1274 DDLSTDGGSLYEA 1286
Score = 45.1 bits (105), Expect = 2e-04
Identities = 73/408 (17%), Positives = 170/408 (41%), Gaps = 36/408 (8%)
Query: 28 EAELRKLRQQFRKM--VESRKSFKFRNQQKIASQYKEIKTLKTEQDEITLLLSLMKSSRN 85
+A RK+ F K+ ++SR + + + + E+K L ++ ++T+ ++ ++
Sbjct: 572 DATKRKVNLVFEKIQTLKSRAAGSAQGNNQACNSTSEVKDLLEQKSKLTIEVAELQRQLQ 631
Query: 86 MN-RSEKNYMELRL-----LLQTKEDYEALIKSLKVLLAELDEKILQMEKKIANQKQI-F 138
+ ++++N E R L + + + ++ L L+E ++ K + Q+
Sbjct: 632 LEVKNQQNIKEERERMRANLEELRSQHNEKVEENSTLQQRLEESEGELRKNLEELFQVKM 691
Query: 139 AKMQEANNPRKLQKQIHILETRLNLVTVHFDK----MLTTNAKLRKEIEDLRFEKAAYDN 194
+ Q R LQ Q+ + L+ D+ ++ + +++++DL K ++
Sbjct: 692 EREQHQTEIRDLQDQLSEMHDELDSAKRSEDREKGALIEELLQAKQDLQDLLIAKEEQED 751
Query: 195 VYQQLQHCLLMEKKTMNLAIEQSSQAYEQRVEAM-ARMAAMKDRQKKDTSQYNLEIRELE 253
+ ++ + L K + + Q ++ E A + A+++ ++ T N+E+
Sbjct: 752 LLRKRERELTALKGALKEEVSSHDQEMDKLKEQYDAELQALRESVEEATK--NVEVLASR 809
Query: 254 RLYAHESKLKSFLLVKLNDRNEFEEQAKREEALKAKKHVKKNRGESFESYEVAHLRLLKL 313
+ + + + + VKL + E E+ R E L+ + + + E + E LK
Sbjct: 810 SNTSEQDQAGTEMRVKLL-QEENEKLQGRSEELERRVAQLQRQIEDLKGDEAKAKETLKK 868
Query: 314 AESGNLNQLIEDFLAKEEKNFARFTYVTELNNDMEMMHKRTQRIQDEIILLRSQQKLSHD 373
E G + QL E + ++ + L N++E +Q LS
Sbjct: 869 YE-GEIRQLEEALVHARKEEKEAVSARRALENELEA----------------AQGNLSQT 911
Query: 374 DNHSVLRQLEDKLRKTTEEADMYESKYGEVSKTLDLLKNSVEKLFKKI 421
+QL +KL++ +E+ + E+ L ++EKL K++
Sbjct: 912 TQEQ--KQLSEKLKEESEQKEQLRRLKNEMENERWHLGKTIEKLQKEM 957
>gi|22538387 A-kinase anchor protein 9 isoform 2 [Homo sapiens]
Length = 3907
Score = 58.5 bits (140), Expect = 2e-08
Identities = 93/484 (19%), Positives = 206/484 (42%), Gaps = 56/484 (11%)
Query: 24 EQQAEAELRKLRQQFRKMVES-RKSFKFRNQQKIASQYK------EIKTLKTEQDEITLL 76
EQ+ EL LRQQ + + + K KF ++Q I +++ EI+ L+ + +
Sbjct: 2041 EQEKNTELMDLRQQNQALEKQLEKMRKFLDEQAIDREHERDVFQQEIQKLEQQLKVVPRF 2100
Query: 77 LSLMKSSRNMNRSEKNYMELRL-----LLQTKEDYEALIKSLKVLLAELDEKILQMEKKI 131
+ + N+++ + LL +KE + I+ + +L+ ++ ++E+ +
Sbjct: 2101 QPISEHQTREVEQLANHLKEKTDKCSELLLSKEQLQRDIQERNEEIEKLEFRVRELEQAL 2160
Query: 132 ANQKQIFAKMQEANNPRKLQKQIHI-LETRLNLVTVHFDKMLTTNAKLRKEIEDLRFEKA 190
F K+++ + ++ + + LE +L D+ L +++E R E
Sbjct: 2161 LVSADTFQKVEDRKHFGAVEAKPELSLEVQLQAERDAIDRKEKEITNLEEQLEQFREELE 2220
Query: 191 AYDNVYQQLQHCLLMEKKTMNLAIEQSSQAYEQRVEAMARMA-AMKDRQKKDTSQYNLEI 249
+ QQL L ++KK +++ Q + + M ++ A+K+ T ++
Sbjct: 2221 NKNEEVQQLHMQLEIQKKESTTRLQELEQENKLFKDDMEKLGLAIKESDAMSTQDQHVLF 2280
Query: 250 R-----------ELERLYAHESKLKSFLLVK-----LNDRNEF--EEQAKREEALKAKKH 291
E+++L +KL+ L + + ++NE + + + E + ++
Sbjct: 2281 GKFAQIIQEKEVEIDQLNEQVTKLQQQLKITTDNKVIEEKNELIRDLETQIECLMSDQEC 2340
Query: 292 VKKNRGESFESYEVAHLRLLKLAESGNLNQLIEDFLAKEEKNFARFTYVT--ELNNDMEM 349
VK+NR E E LN++IE L +E N + T + L+ + +
Sbjct: 2341 VKRNREEEIEQ----------------LNEVIEK-LQQELANIGQKTSMNAHSLSEEADS 2383
Query: 350 MHKRTQRIQDEIILLRSQQKLSHDDN---HSVLRQLEDKLRKTTEEADMYESKYGEVSKT 406
+ + + E + L Q + ++++ +VL++ K+ + T+E + + V K
Sbjct: 2384 LKHQLDVVIAEKLALEQQVETANEEMTFMKNVLKETNFKMNQLTQELFSLKRERESVEKI 2443
Query: 407 LDLLKNSVEKLFKKINCDATKILVQLGETGKVTDINLPQYFAIIEKKTNDLLLLETYRRI 466
+ +NSV ++ D ++ V L E + N + + E ++ LET R+
Sbjct: 2444 QSIPENSVNVAIDHLSKDKPELEVVLTEDALKSLENQTYFKSFEENGKGSIINLET--RL 2501
Query: 467 LEVE 470
L++E
Sbjct: 2502 LQLE 2505
Score = 52.0 bits (123), Expect = 1e-06
Identities = 107/545 (19%), Positives = 220/545 (40%), Gaps = 96/545 (17%)
Query: 4 LKKNRRKDSDTPQEPSEKAKEQQAEAELRKLRQQFRKMVESR-----------------K 46
L++ RR+ +T +E E ++ Q KL+ QF+++ S K
Sbjct: 214 LQQARREKDETMREFLELTEQSQ------KLQIQFQQLQASETLRNSTHSSTAADLLQAK 267
Query: 47 SFKFRNQQKIASQYKEIKTLKTEQDEITLLLSLMKSSRNMNRSEKNYMELRLLLQTKEDY 106
+QQ++ Q ++ + ++++ T+ +S ++ + E+ + ++ KE+
Sbjct: 268 QQILTHQQQLEEQDHLLEDYQKKKEDFTMQISFLQEKIKVYEMEQ---DKKVENSNKEE- 323
Query: 107 EALIKSLKVLLAELDEKILQMEKKIAN---------------QKQIFAKMQEANNPRKLQ 151
I+ + ++ EL+ KI++ EKK Q+QI K QE N ++
Sbjct: 324 ---IQEKETIIEELNTKIIEEEKKTLELKDKLTTADKLLGELQEQIVQKNQEIKN---MK 377
Query: 152 KQIHILETRLNLVTVHFDKMLTTNAKLRK-EIEDLRFEKAAYDNVYQQLQHCLLMEKKTM 210
++ + + + +++ T +L+K +D +FE + Q+ Q L + +
Sbjct: 378 LELTNSKQKERQSSEEIKQLMGTVEELQKRNHKDSQFETDIVQRMEQETQRKLEQLRAEL 437
Query: 211 NLAIEQSSQAYEQRV--EAMARMAAMKDRQKKDTSQYNLEIRELERLYAHESKLK----- 263
+ Q +Q + + MA+M MK R K + +R + +E ++K
Sbjct: 438 DEMYGQQIVQMKQELIRQHMAQMEEMKTRHKGEMEN---ALRSYSNITVNEDQIKLMNVA 494
Query: 264 -SFLLVKLNDRNEFEEQAKREEALKAKKHVKKNR-------GESFESYEVAHLRLLKLAE 315
+ L +KL D N +E+ K E L ++ R SF ++ R +
Sbjct: 495 INELNIKLQDTNSQKEKLKEELGLILEEKCALQRQLEDLVEELSFSREQIQRARQTIAEQ 554
Query: 316 SGNLNQ------LIEDFLA--------KEEKNFARFTYVTELNNDMEMMHKRTQRIQD-- 359
LN+ +ED A ++E VT +EM+ K + D
Sbjct: 555 ESKLNEAHKSLSTVEDLKAEIVSASESRKELELKHEAEVTNYKIKLEMLEKEKNAVLDRM 614
Query: 360 ------EIILLRSQQKLSHDDNHSVLRQ-LEDKLRKTTEEADMYESKYGEVSKTLDLLKN 412
E+ LR+Q SH++ S L++ LE + R E+ + ++ + +D L+N
Sbjct: 615 AESQEAELERLRTQLLFSHEEELSKLKEDLEIEHRINIEK--LKDNLGIHYKQQIDGLQN 672
Query: 413 SVEKLFKKINCDATKILVQ----LGETGKVTDINLPQYFAIIEKKTNDLLLLETYRRILE 468
+ + + + + ++ + + E K+ D+ + E+ T + L+ IL
Sbjct: 673 EMSQKIETMQFEKDNLITKQNQLILEISKLKDLQQSLVNSKSEEMTLQINELQKEIEILR 732
Query: 469 VEGAE 473
E E
Sbjct: 733 QEEKE 737
Score = 42.7 bits (99), Expect = 9e-04
Identities = 84/450 (18%), Positives = 190/450 (42%), Gaps = 43/450 (9%)
Query: 3 VLKKNRRKDSDTPQEPSEKAKEQQAEAELRKLRQQFRKMVESRKSFKFRNQQKIASQYKE 62
+L+ ++ KD Q+ +K ++ ++ +L+++ + + K Q+ Q K
Sbjct: 696 ILEISKLKDL---QQSLVNSKSEEMTLQINELQKEIEILRQEEKEKGTLEQEVQELQLKT 752
Query: 63 I---KTLKTEQDEITLLLSLMKSSRNMNRSEKNYMELRLLLQTKEDYEALIKSLKVLLAE 119
K +K +++++ + +++ ++ + EK +E L + T E + L + ++
Sbjct: 753 ELLEKQMKEKENDLQEKFAQLEAENSILKDEKKTLEDMLKIHTPVSQEERLIFLDSIKSK 812
Query: 120 LDEKILQMEKKIANQKQIFAKMQEANNPRKLQKQIHILETRLNLVTVHFDKMLTTNAKLR 179
+ + + E +I ++ K Q +++KQ + V++ ++ A L
Sbjct: 813 SKDSVWEKEIEILIEENEDLKQQCIQLNEEIEKQRNTFSFAEKNFEVNYQELQEEYACLL 872
Query: 180 KEIEDLRFEKAAYDNVYQQLQHCLLMEKKTMNL---AIEQSSQAYEQRVEAMARMAAMKD 236
K +DL K + Y+ L E + ++ S +++ +A M +
Sbjct: 873 KVKDDLEDSKNKQELEYKSKLKALNEELHLQRINPTTVKMKSSVFDEDKTFVAETLEMGE 932
Query: 237 RQKKDTSQY--NLEIRELERL--------YAHESKLKSFLLVKLNDRNEFEEQAKREEAL 286
+KDT++ LE+ + E+L + + K K + LN+ + +Q K + +L
Sbjct: 933 VVEKDTTELMEKLEVTKREKLELSQRLSDLSEQLKQKHGEISFLNEEVKSLKQEKEQVSL 992
Query: 287 KAKK---HVKKNRGESFESYEVAHLRLLKLAESGNLNQLIEDFLAKEEKNFARFTYV-TE 342
+ ++ + NR E+ +S + LL + ++ E ++K K+F + + E
Sbjct: 993 RCRELEIIINHNRAENVQSCDTQVSSLLDGVVT-MTSRGAEGSVSKVNKSFGEESKIMVE 1051
Query: 343 LNNDMEMMHKRTQRIQDEIILLRSQQKLSHDDNHSVLRQLEDKLRKTTEEADMYESKYGE 402
E M + Q+++IL D SV + E LR T S+ +
Sbjct: 1052 DKVSFENMTVGEESKQEQLIL---------DHLPSVTK--ESSLRAT------QPSENDK 1094
Query: 403 VSKTLDLLKNSVEKLFKKINCDATKILVQL 432
+ K L++LK+ L ++ +A +I + L
Sbjct: 1095 LQKELNVLKSEQNDL--RLQMEAQRICLSL 1122
Score = 37.7 bits (86), Expect = 0.028
Identities = 90/484 (18%), Positives = 187/484 (38%), Gaps = 101/484 (20%)
Query: 7 NRRKDSDTPQEPSEKAKEQQAEAELRKLRQQFRKMVESRKSFKFRN---QQKIASQYKEI 63
N RK + ++ SEK ++ E +++ + Q +M S K R Q++++S+ +
Sbjct: 3102 NGRKITLKREQESEKPSQELLEYNIQQKQSQMLEMQVELSSMKDRATELQEQLSSEKMVV 3161
Query: 64 KTLKTEQDEITLLLSLMKSSRNMNRSEKNYMELRLLLQTKEDYEALIKSLKVLLAELDEK 123
LK+E L QTK + E +K+ L EL+
Sbjct: 3162 AELKSE-----------------------------LAQTKLELETTLKAQHKHLKELEAF 3192
Query: 124 ILQMEKKIANQKQIFAKM-QEANNPRKLQKQIHILETRLNLVTVHFDKMLTTNAKLRKEI 182
L+++ K + + E R+LQ + + +L + + ++E+
Sbjct: 3193 RLEVKDKTDEVHLLNDTLASEQKKSRELQWALEKEKAKLG----------RSEERDKEEL 3242
Query: 183 EDLRFEKAAYDNVYQQLQHCLLMEKKTMNLAIEQSSQAYEQRVEAMARMAAMKDRQKKDT 242
EDL+F ++ Q Q L +NL +EQ Q + + + + D Q +
Sbjct: 3243 EDLKF------SLESQKQRNL-----QLNLLLEQQKQLLNESQQKIESQRMLYDAQLSEE 3291
Query: 243 SQYNLEIR---ELERLYAHESKLKSFLLVKLNDRNEFEEQAKREEALKAKKHVKKNRGES 299
NLE++ E E++ E +L+ + + + + + + K +
Sbjct: 3292 QGRNLELQVLLESEKVRIREMSSTLDRERELHAQLQSSDGTGQSRPPLPSEDLLKELQKQ 3351
Query: 300 FESYEVAHLRLLKLAESGNLNQLIEDFLAKEEKNFARFTYVTELNNDME---MMHKRTQR 356
E + LL E L+ L ++++ R T TE + E MH+ +
Sbjct: 3352 LEEKHSRIVELLNETEKYKLDSLQTRQQMEKDRQVHRKTLQTEQEANTEGQKKMHELQSK 3411
Query: 357 IQDEIILLRSQQKLSHDDNHSVLRQLEDKLRKTTEEADMYESKYGEVSKTLDLLKNSVEK 416
++D + RQLE+K R+ + D+ + + + + K +E+
Sbjct: 3412 VED------------------LQRQLEEK-RQQVYKLDLEGQRLQGIMQ--EFQKQELER 3450
Query: 417 LFKKINCDATKILVQLGETGKVTDINLPQYFAIIEKKTNDLLLLE---------TYRRIL 467
K+ ++ +IL Q ++N P +++ +T + +L + Y +++
Sbjct: 3451 EEKR---ESRRILYQ--------NLNEPTTWSLTSDRTRNWVLQQKIEGETKESNYAKLI 3499
Query: 468 EVEG 471
E+ G
Sbjct: 3500 EMNG 3503
Score = 31.6 bits (70), Expect = 2.0
Identities = 67/327 (20%), Positives = 124/327 (37%), Gaps = 77/327 (23%)
Query: 21 KAKEQQAEAELRKLRQQFRKMVESRKSFKFRNQQKIASQYKEIKTL------KTEQD--- 71
K EQ EAE+ L+++ + + ES + ++ +T+ K D
Sbjct: 1355 KETEQNYEAEIHCLQKRLQAVSESTVPPSLPVDSVVITESDAQRTMYPGSCVKKNIDGTI 1414
Query: 72 EITLLLSLMKSSRNMNRSEKNYMELRLLLQTKEDYEALIKSLKVLLAELDE--KILQMEK 129
E + + + + + EK Y E Q +E+ +I S+ + A+ E +I ++
Sbjct: 1415 EFSGEFGVKEETNIVKLLEKQYQE-----QLEEEVAKVIVSMSIAFAQQTELSRISGGKE 1469
Query: 130 KIANQKQIFAKMQEANNPRKLQKQIHILETRLNLVTVHFDKMLTTNAKLRKEIEDLRFEK 189
A+ KQ A Q Q+Q + E +L+ + F T + K ++E + L E
Sbjct: 1470 NTASSKQAHAVCQ--------QEQHYFNEMKLSQDQIGFQTFETVDVKFKEEFKPLSKEL 1521
Query: 190 AAY--------------------------------------DNVYQQL--------QHCL 203
+ +++ ++ + +
Sbjct: 1522 GEHGKEILLSNSDPHDIPESKDCVLTISEEMFSKDKTFIVRQSIHDEISVSSMDASRQLM 1581
Query: 204 LMEKKTMNLAIEQSSQAYE-QRVEAMARMAAMK--DRQKKDTSQYNLEIRELERLYAHES 260
L E++ ++ E Q E Q+ + R A M+ +RQ++D Q EI+ L R A S
Sbjct: 1582 LNEEQLEDMRQELVRQYQEHQQATELLRQAHMRQMERQREDQEQLQEEIKRLNRQLAQRS 1641
Query: 261 KLKSFLLVKLNDRNEFEEQAKREEALK 287
+ + LV +R EE EALK
Sbjct: 1642 SIDNENLVSERERVLLEEL----EALK 1664
>gi|31542634 filamin A interacting protein 1 [Homo sapiens]
Length = 1213
Score = 58.5 bits (140), Expect = 2e-08
Identities = 106/491 (21%), Positives = 208/491 (42%), Gaps = 78/491 (15%)
Query: 4 LKKNRRKDSDTPQEPSEKAKEQQAEAELRKLRQQFRKMVESRKSFKFRNQQKIASQYKEI 63
L + R++ + + + K+KE + + L KL F K+A+Q
Sbjct: 271 LTQKLREEEEKLKAITSKSKEDRQK--LLKLEVDFEHKASRFSQEHEEMNAKLANQESHN 328
Query: 64 KTLKTEQDEITLLLS-LMKSSRNMNRSEKNYMELRLLLQTKEDYEALIKSLKVLLAELDE 122
+ L+ + +T + L ++++N+ ++E+ ELR + E + SL + L +
Sbjct: 329 RQLRLKLVGLTQRIEELEETNKNLQKAEEELQELRDKIAKGECGNS---SLMAEVENLRK 385
Query: 123 KILQMEKKIANQKQIFAKMQEANNPRKLQKQIHILETRLNLVTVHFDKMLTTNAKLRKEI 182
++L+ME K + ++ +E +KLQ++ H H ++ KL+K +
Sbjct: 386 RVLEMEGKDEEITKTESQCRELR--KKLQEEEH-----------HSKELRLEVEKLQKRM 432
Query: 183 EDLRFEKAAYDNVYQQLQHCLLMEKKTMNLAIEQSSQAYEQRVEAMARMAAMKDRQKK-D 241
+L + A+ + L +K NL + + + +K R K+ +
Sbjct: 433 SELEKLEEAFSKSKSECTQLHLNLEKEKNLT-----------KDLLNELEVVKSRVKELE 481
Query: 242 TSQYNLEIRELERLYAHESKLKSFLLVKLNDRNEFEEQAKREEAL--KAKKHVKKNRGES 299
S+ LE EL L +KLKSF ++ +++R E+ K+EE K+ K +G+
Sbjct: 482 CSESRLEKAELS-LKDDLTKLKSFTVMLVDERKNMMEKIKQEERKVDGLNKNFKVEQGKV 540
Query: 300 FESYE---VAHLRLLKLAE---------SGNLNQLIEDFLAKEEKNFARFTYVTELNNDM 347
+ E +LLKL + ++LI ++EEK+ +EL+ +
Sbjct: 541 MDVTEKLIEESKKLLKLKSEMEEKVYNLTRERDELIGKLKSEEEKS-------SELSCSV 593
Query: 348 EMMHKRTQRIQD---EIILLRSQQ--KLSHDDNHSV----------------LRQLEDKL 386
+++ KR I++ EI RS++ +L+ +++ + L +E L
Sbjct: 594 DLLKKRLDGIEEVEREITRGRSRKGSELTCPEDNKIKELTLEIERLKKRLQQLEVVEGDL 653
Query: 387 RKTTEEADMYESKYGEVSKTLDLLKNSVEKLFKKINCDATKILVQLGETGKVTDINLPQY 446
KT +E D E K+ + L +E++ +I A ++ GE + L
Sbjct: 654 MKTEDEYDQLEQKFRTEQDKANFLSQQLEEIKHQI---AKNKAIEKGEVVS-QEAELRHR 709
Query: 447 FAIIEKKTNDL 457
F + E K+ DL
Sbjct: 710 FRLEEAKSRDL 720
Score = 47.0 bits (110), Expect = 5e-05
Identities = 105/501 (20%), Positives = 201/501 (40%), Gaps = 86/501 (17%)
Query: 22 AKEQQAEAELRKLRQQFRKMVESRKSFKFRNQQKIASQY--KEIKTLKTEQDEITLLLSL 79
A E+ + +K ++ RK + S + K + + K K+L+ ++++ LLS+
Sbjct: 27 AGEKSLSEDAKKKKKSNRKEDDVMASGTVKRHLKTSGECERKTKKSLELSKEDLIQLLSI 86
Query: 80 MKSSR-------NMNRSEKNYMELRLLLQTKEDYEALIKSLKVLLAELDEKILQMEKKIA 132
M+ +M ++EK E+ E + + KVL + IL EK I
Sbjct: 87 MEGELQAREDVIHMLKTEKTKPEVL------EAHYGSAEPEKVLRVLHRDAILAQEKSIG 140
Query: 133 NQKQIFAK-MQEANNPRKLQKQIH--ILETRLNLVTVHFDKMLTTNAKLRKEIEDLRFEK 189
+ ++ K + E + + QK+ + +LE L H + E+E+ + +
Sbjct: 141 --EDVYEKPISELDRLEEKQKETYRRMLEQLLLAEKCH--------RRTVYELENEKHKH 190
Query: 190 AAYDNVYQQLQHCLLMEKKTMNLAIEQSSQAYEQRVEAMARMAAMKDRQKKDTSQYNLEI 249
Y N + L E++ + +EQ +AY+ R E K+ K+
Sbjct: 191 TDYMNKSDDFTNLLEQERERLKKLLEQ-EKAYQARKE--------KENAKR--------- 232
Query: 250 RELERLYAHESKLKSFLLVKLNDRNEFEEQ---------------AKREEALKAKKHVKK 294
L +L KLKSF L+ +++R EQ + EE LKA K
Sbjct: 233 --LNKLRDELVKLKSFALMLVDERQMHIEQLGLQSQKVQDLTQKLREEEEKLKAITSKSK 290
Query: 295 NRGESFESYEV--AHLRLLKLAESGNLNQLIEDFLAKEEKNFARFTYVTELNNDMEMMHK 352
+ EV H E +N + + + + + +T+ ++E +K
Sbjct: 291 EDRQKLLKLEVDFEHKASRFSQEHEEMNAKLANQESHNRQLRLKLVGLTQRIEELEETNK 350
Query: 353 RTQRIQDEIILLRSQQKLSHDDNHSVLRQLEDKLRKTTEEADMYESKYGEVSKTLDLLKN 412
Q+ ++E+ LR + N S++ ++E+ ++ E E K E++KT +
Sbjct: 351 NLQKAEEELQELRDKIAKGECGNSSLMAEVENLRKRVLE----MEGKDEEITKTESQCRE 406
Query: 413 SVEKL------FKKINCDATKILVQLGETGKVTDI------NLPQYFAIIEKK---TNDL 457
+KL K++ + K+ ++ E K+ + Q +EK+ T DL
Sbjct: 407 LRKKLQEEEHHSKELRLEVEKLQKRMSELEKLEEAFSKSKSECTQLHLNLEKEKNLTKDL 466
Query: 458 L--LLETYRRILEVEGAEAEI 476
L L R+ E+E +E+ +
Sbjct: 467 LNELEVVKSRVKELECSESRL 487
Score = 32.3 bits (72), Expect = 1.2
Identities = 66/306 (21%), Positives = 127/306 (41%), Gaps = 40/306 (13%)
Query: 141 MQEANNPRKLQKQIHILETRLNLVTVHFDKMLTTNAKLRKEIEDLRFEKAAYDNVYQQLQ 200
M+ N + HI + +++ +K L+ +AK +K+ + A V + L+
Sbjct: 1 MRSRNQGGESASDGHISCPKPSIIGNAGEKSLSEDAKKKKKSNRKEDDVMASGTVKRHLK 60
Query: 201 HCLLMEKKTMNLAIEQSSQAYEQRVEAMARMAAMKDRQKKDTSQYNLEIRELERLYAHES 260
E+KT ++E S E ++ ++ M ++ E + E L AH
Sbjct: 61 TSGECERKTKK-SLELSK---EDLIQLLSIMEGELQAREDVIHMLKTEKTKPEVLEAHYG 116
Query: 261 KLKSFLLVKLNDRNEFEEQAKREEALKAKKHVKKNRGESFESYEVAHLRLLKLAESGNLN 320
+ ++++ R+ Q +K+ GE ++ L L+ +
Sbjct: 117 SAEPEKVLRVLHRDAILAQ-------------EKSIGEDVYEKPISELDRLEEKQKETYR 163
Query: 321 QLIEDFLAKEEKNFARFTYVTELNNDMEMMHKRTQRIQDEIILLRSQQKLSHDDNHSVLR 380
+++E L E K R Y EL N+ HK T + DD ++L
Sbjct: 164 RMLEQLLLAE-KCHRRTVY--ELENEK---HKHTDYMNKS------------DDFTNLLE 205
Query: 381 QLEDKLRKTTEEADMYES-KYGEVSKTLDLLKNSVEKL--FKKINCDATKI-LVQLG-ET 435
Q ++L+K E+ Y++ K E +K L+ L++ + KL F + D ++ + QLG ++
Sbjct: 206 QERERLKKLLEQEKAYQARKEKENAKRLNKLRDELVKLKSFALMLVDERQMHIEQLGLQS 265
Query: 436 GKVTDI 441
KV D+
Sbjct: 266 QKVQDL 271
>gi|41872583 Rho-associated, coiled-coil containing protein kinase 2
[Homo sapiens]
Length = 1388
Score = 58.2 bits (139), Expect = 2e-08
Identities = 95/441 (21%), Positives = 195/441 (44%), Gaps = 61/441 (13%)
Query: 12 SDTP---QEPSEKAKEQQAEAELRKLRQQFRKMVESRKSFKFRNQQKIASQYKEI-KTLK 67
SD+P + S ++++ + E++K + + + K +QK S + KT K
Sbjct: 423 SDSPSCRETDSIQSRKNEESQEIQKKLYTLEEHLSNEMQAKEELEQKCKSVNTRLEKTAK 482
Query: 68 TEQDEITLLLSLMKSSRNMNRSEKNYMELRLLLQTKEDYEALIK-SLKVLLAELDEKILQ 126
++EITL S+ + R + R + Q K D+EA K +L+ + L +++
Sbjct: 483 ELEEEITLRKSVESALRQLEREKALLQHKNAEYQRKADHEADKKRNLENDVNSLKDQLED 542
Query: 127 MEKKIANQKQIFAKMQEANNPRKLQKQIHILETRLNLVTVHFDKMLTTNAKLRKEIEDLR 186
++K+ N + K+ + LQ+Q+ L + ++ T A+ K+I+ L
Sbjct: 543 LKKRNQNSQISTEKVNQ------LQRQLDETNALLRTESDTAARLRKTQAESSKQIQQLE 596
Query: 187 FEKAAYDNVYQQLQHCLL------MEKKTMNLAIEQSSQAYEQR---------VEAMARM 231
+N Q ++CLL +EK+ +NL QS+ E+R + R+
Sbjct: 597 -----SNNRDLQDKNCLLETAKLKLEKEFINL---QSALESERRDRTHGSEIINDLQGRI 648
Query: 232 AAMKDRQKKD---TSQYNLEIRELERLYAHESKLKSFLLVKLNDRNEFEEQAKREEAL-- 286
+++ K ++ LE R+L+ + K KS + + + + + +Q+ +E
Sbjct: 649 CGLEEDLKNGKILLAKVELEKRQLQERFTDLEKEKSNMEIDMTYQLKVIQQSLEQEEAEH 708
Query: 287 KAKKHVKKNRGESFESYEVAHLRLL-----KLAESGNLNQLIEDFLAKEEKNFARFTYVT 341
KA K ++ + +ES E A + KL E L Q +E+ L + EK +
Sbjct: 709 KATKARLADKNKIYESIEEAKSEAMKEMEKKLLEERTLKQKVENLLLEAEKR------CS 762
Query: 342 ELNNDMEMMHKRTQRIQDEIILLRSQQKLSHDDNHSVLRQLEDKLRKTTEEADMYESKYG 401
L+ D++ ++ LL+ + L+ D +R L K+ + T++ + ++
Sbjct: 763 LLDCDLKQSQQKINE------LLKQKDVLNED-----VRNLTLKIEQETQKRCLTQNDLK 811
Query: 402 EVSKTLDLLKNSVEKLFKKIN 422
++ ++ LK S ++L ++ N
Sbjct: 812 MQTQQVNTLKMSEKQLKQENN 832
Score = 44.3 bits (103), Expect = 3e-04
Identities = 71/371 (19%), Positives = 154/371 (41%), Gaps = 57/371 (15%)
Query: 26 QAEAELRKLRQQFRKMVESRKSFKFRN-------QQKIASQYKEIKTLKTEQDEITLLLS 78
+ E E R+L+++F + + + + + QQ + + E K K + +
Sbjct: 664 KVELEKRQLQERFTDLEKEKSNMEIDMTYQLKVIQQSLEQEEAEHKATKARLADKNKIYE 723
Query: 79 LMKSSRN--MNRSEKNYMELRLLLQTKEDYEALIKSLKVLLAELDEKILQMEKKIANQKQ 136
++ +++ M EK +E R L K+ E L+ + + LD + Q ++KI
Sbjct: 724 SIEEAKSEAMKEMEKKLLEERTL---KQKVENLLLEAEKRCSLLDCDLKQSQQKI----- 775
Query: 137 IFAKMQEANNPRKLQKQIHILETRLNLVTVHFD----KMLTTNAKLRKEIEDLRFEKAAY 192
+L KQ +L + +T+ + K T L+ + + + K +
Sbjct: 776 -----------NELLKQKDVLNEDVRNLTLKIEQETQKRCLTQNDLKMQTQQVNTLKMSE 824
Query: 193 DNVYQQLQHCLLMEKKTMNLAIEQSSQAYEQRVEAMARMAAMKDRQKKD---TSQYNLEI 249
+ Q+ H LME K MNL +Q+++ ++R +A +M ++D+ + + ++ Y ++
Sbjct: 825 KQLKQENNH--LMEMK-MNLE-KQNAELRKERQDADGQMKELQDQLEAEQYFSTLYKTQV 880
Query: 250 RELERLYAHESKLKSFLLVKLNDRNEFEEQAKREEALKAKKHVKKNRGESFESYEVAHLR 309
REL+ ++KL L K + + + + + K + S + + L
Sbjct: 881 RELKEECEEKTKLGKELQQKKQELQDERDSLAAQLEITLTKADSEQLARSIAEEQYSDLE 940
Query: 310 LLKLAESGNLNQLIE-----------DFLAKEEKNFARFTYVT-------ELNNDMEMMH 351
K+ + + +++ + EE N + V ELNN ++ +
Sbjct: 941 KEKIMKELEIKEMMARHKQELTEKDATIASLEETNRTLTSDVANLANEKEELNNKLKDVQ 1000
Query: 352 KRTQRIQDEII 362
++ R++DE I
Sbjct: 1001 EQLSRLKDEEI 1011
>gi|16262452 cingulin [Homo sapiens]
Length = 1203
Score = 58.2 bits (139), Expect = 2e-08
Identities = 92/432 (21%), Positives = 178/432 (41%), Gaps = 48/432 (11%)
Query: 8 RRKDSDTPQEPSEKAKEQQAEAELRKLRQQFRKMVESRKSFKFRNQQKIASQYKEIKTLK 67
R + + +E EK + Q E E + + VE K R Q+++ KE++ +
Sbjct: 593 RMEKEEMEEELGEKIEVLQRELEQARASAGDTRQVEVLKKELLRTQEEL----KELQAER 648
Query: 68 TEQD----------EITLLLSLMKSSRNMNRSEKNYMELRLLLQTKEDYEALIKSLKVLL 117
Q+ E L + +++ R E+N + L Q ++D E K+ V
Sbjct: 649 QSQEVAGRHRDRELEKQLAVLRVEADRGRELEEQNLQLQKTLQQLRQDCEEASKAKMV-- 706
Query: 118 AELDEKILQMEKKIANQKQIFAKMQEANNPRKLQKQIHILETRLNLVTVHFDKMLTTNAK 177
AE + +L + A + + QE N+ + +++I LE +L D A+
Sbjct: 707 AEAEATVLGQRR--AAVETTLRETQEEND--EFRRRILGLEQQLKETRGLVDGGEAVEAR 762
Query: 178 LRKEIEDLRFEKAAYD---NVYQQLQHCLLMEKKTMNLAIEQSSQAYE---QRVEAMARM 231
LR +++ L EK + N Q+ + L K+ + +E++ + Q + + R
Sbjct: 763 LRDKLQRLEAEKQQLEEALNASQEEEGSLAAAKRALEARLEEAQRGLARLGQEQQTLNRA 822
Query: 232 AAMKDRQKKDTSQYNLEIRELERLYAHESKLKSFLLVKLNDRNEFEEQAKREEALKAKKH 291
+ +Q++ + E+ E +RL + L +L E +QA ++ + + +
Sbjct: 823 LEEEGKQREVLRRGKAELEEQKRLL---DRTVDRLNKELEKIGEDSKQALQQLQAQLEDY 879
Query: 292 VKKNRGESFESYEVAHLRLLKLAE-SGNLNQLIEDFLAKEEKNFARFTYVTELNNDMEMM 350
+K R E ++ A + + SG L++L ++ + A D E++
Sbjct: 880 KEKARREVADAQRQAKDWASEAEKTSGGLSRLQDEIQRLRQALQASQAERDTARLDKELL 939
Query: 351 HKRTQRIQDEIILLRSQQKLSHDDNHSVLRQLEDKLRKTTEEADMYESKYGEVSKTLDLL 410
+R Q ++ E +K S DD L+ LE+K+ + E LD
Sbjct: 940 AQRLQGLEQEA----ENKKRSQDDRARQLKGLEEKVSRLETE--------------LDEE 981
Query: 411 KNSVEKLFKKIN 422
KN+VE L ++N
Sbjct: 982 KNTVELLTDRVN 993
Score = 38.5 bits (88), Expect = 0.017
Identities = 93/417 (22%), Positives = 161/417 (38%), Gaps = 84/417 (20%)
Query: 19 SEKAKEQQAEAELRKLRQQFRKMVESRKSFKFRNQQKIASQYKEIKTLKTEQDEITLLLS 78
S KA Q E RK+ + RK+ E K + Q+ SQ + L+ + +E + L
Sbjct: 354 STKAVAGQGELT-RKVEELQRKLDEEVK----KRQKLEPSQVGLERQLEEKTEECSRLQE 408
Query: 79 LMKSSRN-MNRSEKNYMELRLLLQTKEDYEALIKSLKVLLAELDEKILQMEKKIANQKQI 137
L++ + +S K ++ LL ED L L+ ++++++ K+
Sbjct: 409 LLERRKGEAQQSNKELQNMKRLLDQGED----------LRHGLETQVMELQNKL------ 452
Query: 138 FAKMQEANNPRKLQKQIHILETRLNLVTVHFDKMLTTNAKLRKEIEDLRFEKAAYDNVYQ 197
K + P K +LETR L V K R E E LR +
Sbjct: 453 --KHVQGPEPAKEVLLKDLLETRELLEEV-------LEGKQRVE-EQLRLR----ERELT 498
Query: 198 QLQHCLLMEKKTMNLAIEQSSQAYEQRVEAMARMAAMKD-----------RQKKDTSQYN 246
L+ L E + + +E Q Y++ E + R +M+D RQK
Sbjct: 499 ALKGALKEEVASRDQEVEHVRQQYQRDTEQLRR--SMQDATQDHAVLEAERQKMSALVRG 556
Query: 247 LEIRELERLYAHESKLKSFLLVKLNDRNEFEEQAKREEALKAKKHVKKNRGESFESYEVA 306
L+ RELE +S +N+ + +A ++E L+ + ++ E E EV
Sbjct: 557 LQ-RELEETSEETGHWQSMF-----QKNKEDLRATKQELLQLRMEKEEMEEELGEKIEVL 610
Query: 307 HLRLLKL-AESGNLNQLIEDFLAKEEKNFARFTYVTELNNDMEMMHKRTQRIQDEIILLR 365
L + A +G+ Q+ E++ K R Q+E+ L+
Sbjct: 611 QRELEQARASAGDTRQV-------------------------EVLKKELLRTQEELKELQ 645
Query: 366 SQQKLSHDDNHSVLRQLEDKLRKTTEEADM---YESKYGEVSKTLDLLKNSVEKLFK 419
++++ R+LE +L EAD E + ++ KTL L+ E+ K
Sbjct: 646 AERQSQEVAGRHRDRELEKQLAVLRVEADRGRELEEQNLQLQKTLQQLRQDCEEASK 702
Score = 33.5 bits (75), Expect = 0.53
Identities = 81/440 (18%), Positives = 179/440 (40%), Gaps = 52/440 (11%)
Query: 17 EPSEKAKEQQAEAELRKLRQQFRKMVESRKSFKFRNQQ---KIASQYKEIKTLKTEQDEI 73
E + KAK AEAE L Q+ + + + + N + +I +++K + D
Sbjct: 698 EEASKAK-MVAEAEATVLGQRRAAVETTLRETQEENDEFRRRILGLEQQLKETRGLVDGG 756
Query: 74 TLLLSLMKSSRNMNRSEKNYMELRLLLQTKEDYEALIKSLKVLLAELDEKILQMEKKIAN 133
+ + ++ +EK +E L ++E+ +L + + L A L+E + +
Sbjct: 757 EAVEARLRDKLQRLEAEKQQLE-EALNASQEEEGSLAAAKRALEARLEEAQRGLARLGQE 815
Query: 134 QKQIFAKMQEANNPRK--------LQKQIHILETRLNLVTVHFDKMLTTNAK----LRKE 181
Q+ + ++E R+ L++Q +L+ ++ + +K+ + + L+ +
Sbjct: 816 QQTLNRALEEEGKQREVLRRGKAELEEQKRLLDRTVDRLNKELEKIGEDSKQALQQLQAQ 875
Query: 182 IEDLRFEKAAYDNVYQQLQHCLLMEKKTMNLAIEQSSQAYEQRVEAMARM--AAMKDRQK 239
+ED + EKA + Q Q K E++S + + + R+ A + +
Sbjct: 876 LEDYK-EKARREVADAQRQ------AKDWASEAEKTSGGLSRLQDEIQRLRQALQASQAE 928
Query: 240 KDTSQYNLEI--RELERLYAHESKLKSFLLVKLNDRNEFEEQAKR-EEALKAKKHV---- 292
+DT++ + E+ + L+ L K + EE+ R E L +K+
Sbjct: 929 RDTARLDKELLAQRLQGLEQEAENKKRSQDDRARQLKGLEEKVSRLETELDEEKNTVELL 988
Query: 293 --KKNRGESFESYEVAHLRLLKLAESGNLNQLIEDFLAKEEKNFARFTYV---------- 340
+ NRG +V LR + E L D ++ E +N T +
Sbjct: 989 TDRVNRGRD----QVDQLRTELMQERSARQDLECDKISLERQNKDLKTRLASSEGFQKPS 1044
Query: 341 ---TELNNDMEMMHKRTQRIQDEIILLRSQQKLSHDDNHSVLRQLEDKLRKTTEEADMYE 397
++L + +++ +R Q + E +L+S + + Q+ED+ + ++ D
Sbjct: 1045 ASLSQLESQNQLLQERLQAEEREKTVLQSTNRKLERKVKELSIQIEDERQHVNDQKDQLS 1104
Query: 398 SKYGEVSKTLDLLKNSVEKL 417
+ + + +D + +E+L
Sbjct: 1105 LRVKALKRQVDEAEEEIERL 1124
>gi|150010558 myosin, heavy polypeptide 15 [Homo sapiens]
Length = 1946
Score = 58.2 bits (139), Expect = 2e-08
Identities = 102/452 (22%), Positives = 184/452 (40%), Gaps = 64/452 (14%)
Query: 6 KNRRKDSDTPQEPSEKAKE------QQAEAELRKLRQQFRKMVESRKSFKFRNQQ----- 54
K D +T SEK K + E+ L + K+ + K + +QQ
Sbjct: 963 KKEIDDLETMLVKSEKEKRTTEHKVKNLTEEVEFLNEDISKLNRAAKVVQEAHQQTLDDL 1022
Query: 55 -----KIASQYKEIKTLKTEQDEITLLLSLMKSSRNMNRSEKNYMELRLLLQTKEDYEAL 109
K++S K L+ + DE+ L + +R E + +E L L +E E L
Sbjct: 1023 HMEEEKLSSLSKANLKLEQQVDELEGALEQERKARMNCERELHKLEGNLKLN-RESMENL 1081
Query: 110 IKSLKVLLAELDEKIL---QMEKKIANQKQIFAKMQEANNPRKLQKQIHILETRLNLVTV 166
S + L EL +K L QM K+ N+K + A++Q+ ++LQ QI L+ +L
Sbjct: 1082 ESSQRHLAEELRKKELELSQMNSKVENEKGLVAQLQKT--VKELQTQIKDLKEKL----- 1134
Query: 167 HFDKMLTTNAKLRKEIEDLRFEKAAYDNVYQQLQHCLLMEKKTMNLAIEQSSQAYEQRVE 226
+ TT AK+ +E DL + A + +++ L + + + + + E
Sbjct: 1135 --EAERTTRAKMERERADLTQDLADLNERLEEVGGSSLAQLEITKKQETKFQKLHRDMEE 1192
Query: 227 AMARM----AAMKDRQKKDTSQYNLEIRELERLYAHESKLKSFLLVKLNDRNEFEEQAKR 282
A A++K R ++ ++ L+++ K KS L ++++D EQ R
Sbjct: 1193 ATLHFETTSASLKKRHADSLAELEGQVENLQQVKQKLEKDKSDLQLEVDDLLTRVEQMTR 1252
Query: 283 EEALKAK----------KHVKKNRGESFESYEVAHLRLLKLAESGNLNQLIED------F 326
+A K + K + + ++A + +ESG + +E+
Sbjct: 1253 AKANAEKLCTLYEERLHEATAKLDKVTQLANDLAAQKTKLWSESGEFLRRLEEKEALINQ 1312
Query: 327 LAKEEKNFARFTYVTELNNDMEMMHK-------RTQRIQDEIILLRSQQKLSHDDNHSVL 379
L++E+ NF R + +L +E K Q+ Q + LLR Q +++ V
Sbjct: 1313 LSREKSNFTR--QIEDLRGQLEKETKSQSALAHALQKAQRDCDLLREQ----YEEEQEVK 1366
Query: 380 RQLEDKLRKTTEEADMYESKY--GEVSKTLDL 409
+L L K E + KY + +T DL
Sbjct: 1367 AELHRTLSKVNAEMVQWRMKYENNVIQRTEDL 1398
Score = 55.1 bits (131), Expect = 2e-07
Identities = 98/476 (20%), Positives = 204/476 (42%), Gaps = 41/476 (8%)
Query: 9 RKDSDTPQEPSEKAKEQQAEAEL-RKLRQQFRKMVESRKSFKFRNQQKIASQYKEIKTLK 67
++D D +E E+ EQ+ +AEL R L + +MV+ R ++ Q+ K L
Sbjct: 1349 QRDCDLLREQYEE--EQEVKAELHRTLSKVNAEMVQWRMKYENNVIQRTEDLEDAKKELA 1406
Query: 68 TEQDEITLLLSLMKSSRNMNRSEKNYMELRLLLQTKEDYEALIKSLKVLLAELDEKILQM 127
E + + + ++ ++L L D + + ++ A LD+K LQ
Sbjct: 1407 IRLQEAAEAMGVANARNASLERARHQLQLEL-----GDALSDLGKVRSAAARLDQKQLQS 1461
Query: 128 EKKIANQKQIFAKMQEANNPRKLQKQIHILETRLNLVTVHFDKMLTTNAKLRKEIEDLRF 187
K +A+ KQ + Q + QK++ L T L + +++ + LR+E ++L+
Sbjct: 1462 GKALADWKQKHEESQALLDAS--QKEVQALSTELLKLKNTYEESIVGQETLRRENKNLQE 1519
Query: 188 EKAAYDNVYQQLQHCLLMEKKTMNLAIEQSSQAYEQRVEAMARMAAMKDRQKKDTSQYNL 247
E + N ++ L +K L E+ ++ E + +R + + L
Sbjct: 1520 EISNLTNQVREGTKNLTEMEKVKKLIEEEKTEVQVTLEETEGAL----ERNESKILHFQL 1575
Query: 248 EI----RELER-LYAHESKLKSFLLVKL----NDRNEFEEQAK-REEALKAKKHVKKNRG 297
E+ ELER L + ++++F + + ++ + +AK R E + KK ++++
Sbjct: 1576 ELLEAKAELERKLSEKDEEIENFRRKQQCTIDSLQSSLDSEAKSRIEVTRLKKKMEEDLN 1635
Query: 298 ESFESYEVAHLRLLKLAES-GNLNQLIEDFLAKEEKNFARFTYVTELNNDME----MMHK 352
E A+ ++ + +S G L I+D + + + T+LN+D++ + +
Sbjct: 1636 EMELQLSCANRQVSEATKSLGQLQIQIKDLQMQLDDS-------TQLNSDLKEQVAVAER 1688
Query: 353 RTQRIQDEIILLRSQQKLSHDDNHSVLRQLEDKLRKTTEEADMYESKYGEVSKTLDLLKN 412
R +Q E+ LRS Q+ + R E++L + TE +++ ++ + L+
Sbjct: 1689 RNSLLQSELEDLRSLQEQTERGR----RLSEEELLEATERINLFYTQNTSLLSQKKKLEA 1744
Query: 413 SVEKLFKKINCDATKILVQLGETGKVTDINLPQYFAIIEKKTNDLLLLETYRRILE 468
V ++ K+ + + E K I ++KK + + LE R +E
Sbjct: 1745 DVARMQKEAE-EVVQECQNAEEKAKKAAIEAANLSEELKKKQDTIAHLERTRENME 1799
>gi|222418637 golgi autoantigen, golgin subfamily a-like [Homo
sapiens]
Length = 750
Score = 57.8 bits (138), Expect = 3e-08
Identities = 88/440 (20%), Positives = 199/440 (45%), Gaps = 46/440 (10%)
Query: 20 EKAKEQQAEAELRKLRQQFRKMVESRKSFKFRNQQKIASQYKEIKTL------KTEQDEI 73
E+ KE+ A+ Q+ ++VES KS N +++ + + K L + E D +
Sbjct: 217 EELKEKNAKL------QEKLQLVESEKSEIQLNVKELKRKLERAKLLLPQQQLQAEADHL 270
Query: 74 TLLLSLMKSSRNMNRSEKNYMELRLLLQTKE----------DYEALIKSLKVLLAELDEK 123
L + S++ + E+N + RL Q +E ++E I+ + + E +EK
Sbjct: 271 GKELQSV-SAKLQAQVEENELWNRLNQQQEEKMWRQEEKIQEWEEKIQEQEEKIREQEEK 329
Query: 124 ILQMEKKIANQKQIFAKMQEANNPRKLQKQIHILETRLNLVTVHFDKMLTTNAKLRKEIE 183
I + E+K+ Q+++ + +E K+++Q ++ + + + M K+R++ E
Sbjct: 330 IREQEEKMRRQEEMMWEKEE-----KMRRQEEMMWEKEEKMRRQEEMMWEKEEKMRRQ-E 383
Query: 184 DLRFEKAAYDNVYQQLQHCLLMEKKTMNLAIEQSSQAYEQRVEAMARMAAMKDRQKKDTS 243
++ +EK + ++L+ + ++K ++ + + E A RQ++
Sbjct: 384 EMMWEK---EEKIRELEEKMHEQEKIREQEEKRQEEEKIREQEKRQEQEAKMWRQEEKIR 440
Query: 244 QYNLEIRELE-RLYAHESKLKSFLLVKLND-RNEFEEQAKREEALKAKKHVKKNRGESFE 301
+ +IRE E +++ E K+ ++ + R E EE ++EE + ++ + + + + E
Sbjct: 441 EQEEKIREQEKKMWRQEEKIHEQEKIREEEKRQEQEEMWRQEEKIHEQEEIWRQKEKMHE 500
Query: 302 SYEVAHLRLLKL-AESGNLNQLIEDFLAKEEKNFARFTYV---TELNNDMEMMHKR---- 353
E + K+ + + + E +EEK + + + E+ + E MH++
Sbjct: 501 QEEKIRKQEEKVWRQEEKIREQEEKIREQEEKMWRQEEKIREQEEMWREEEKMHEQEKIW 560
Query: 354 --TQRIQDEIILLRSQQKLSHDDNHSVLRQLEDKLRKTTEEADMYESKYGEVSKTLDLLK 411
+R + E + R ++K+ + V RQ E+K+R+ E+ E K + + + +
Sbjct: 561 EEEKRQEQEDKMWRQEEKI-REQEEKVWRQ-EEKIREQEEKRQEQEEKMWKQEEKIREQE 618
Query: 412 NSVEKLFKKINCDATKILVQ 431
+++ +KI KI Q
Sbjct: 619 EKIQEQEEKIREQEEKIREQ 638
Score = 57.0 bits (136), Expect = 5e-08
Identities = 78/426 (18%), Positives = 190/426 (44%), Gaps = 35/426 (8%)
Query: 5 KKNRRKDSDTPQEPSEKAKEQQAEAELRKLRQQFRKMVESRKSFKFRNQQKIASQYKEIK 64
K R+++ +E + +E+ + K+R+Q M E K K R Q+++ + KE K
Sbjct: 336 KMRRQEEMMWEKEEKMRRQEEMMWEKEEKMRRQEEMMWE--KEEKMRRQEEMMWE-KEEK 392
Query: 65 TLKTEQDEITLLLSLMKSSRNMNRSEKNYMELRLLLQTK-EDYEALIKSLKVLLAELDEK 123
+ E+ + + + + EK E ++ Q K ++ EA + + + E +EK
Sbjct: 393 IRELEE-------KMHEQEKIREQEEKRQEEEKIREQEKRQEQEAKMWRQEEKIREQEEK 445
Query: 124 ILQMEKKIANQKQIFAKMQEANNPRKLQKQIHILETRLNL-----VTVHFDKMLTTNAKL 178
I + EKK+ Q++ + ++ K Q+Q + + + +KM K+
Sbjct: 446 IREQEKKMWRQEEKIHEQEKIREEEKRQEQEEMWRQEEKIHEQEEIWRQKEKMHEQEEKI 505
Query: 179 RKEIEDL-RFEKAAYDNVYQQLQHCLLMEKKTMNLAIEQSSQAYEQRVEAMARMAAMKDR 237
RK+ E + R E+ + + + M ++ + ++ E+++ ++ + R
Sbjct: 506 RKQEEKVWRQEEKIREQEEKIREQEEKMWRQEEKIREQEEMWREEEKMHEQEKIWEEEKR 565
Query: 238 QKKDTSQYNLE--IREL-ERLYAHESKLKSFLLVKLNDRNEFEEQAKREEALKAKKHVKK 294
Q+++ + E IRE E+++ E K++ E + Q + E+ K ++ +++
Sbjct: 566 QEQEDKMWRQEEKIREQEEKVWRQEEKIR---------EQEEKRQEQEEKMWKQEEKIRE 616
Query: 295 NRGESFESYEVAHLRLLKLAESGNLNQLIEDFLAKEEKNFARFTYVTELNNDMEMMHKRT 354
+ E E + K+ E + Q E+ + ++E+ ++ E M ++
Sbjct: 617 QEEKIQEQEEKIREQEEKIREQEEMTQEQEEKMGEQEEKMCE--QEEKMQEQEETMWRQE 674
Query: 355 QRIQDEIILLRSQQKLSHDDNHSVLRQLEDKLRKTTEEADMYESKYGEVSKTLDLLKNSV 414
++I+++ +R Q++ + ++++ E+K+ + E+ E K E + ++
Sbjct: 675 EKIREQEKKIREQEEKIR-EQEEMMQEQEEKMWEQEEKMCEQEEKMQEQE---EKMRRQE 730
Query: 415 EKLFKK 420
EK++++
Sbjct: 731 EKMWEQ 736
Score = 47.0 bits (110), Expect = 5e-05
Identities = 54/304 (17%), Positives = 137/304 (45%), Gaps = 31/304 (10%)
Query: 5 KKNRRKDSDTPQEPSEKAKEQQAEAELRKLRQQFRKMVESRKSFK------FRNQQKIAS 58
++ + ++ + QE E ++++ E ++ +Q KM E + + +R ++KI
Sbjct: 462 EQEKIREEEKRQEQEEMWRQEEKIHEQEEIWRQKEKMHEQEEKIRKQEEKVWRQEEKIRE 521
Query: 59 QYKEIK----TLKTEQDEITLLLSLMKSSRNMNRSEKNYMELRLLLQTKEDYEALIKSLK 114
Q ++I+ + ++++I + + M+ EK + E + +++ E + +
Sbjct: 522 QEEKIREQEEKMWRQEEKIREQEEMWREEEKMHEQEKIWEE-----EKRQEQEDKMWRQE 576
Query: 115 VLLAELDEKILQMEKKIANQKQIFAKMQEANNPRKLQKQIHILETRLNLVTVHFDKMLTT 174
+ E +EK+ + E+KI Q++ K QE K+ KQ + + + +K+
Sbjct: 577 EKIREQEEKVWRQEEKIREQEE---KRQE--QEEKMWKQEEKIREQEEKIQEQEEKIREQ 631
Query: 175 NAKLRKEIEDLRFEKAAYDNVYQQLQHCLLMEKKTMNLAIEQSSQAYEQRVEAMARMAAM 234
K+R++ E + ++ + + +Q + E+K EQ + Q + + +
Sbjct: 632 EEKIREQEEMTQEQE---EKMGEQEEKMCEQEEKMQ----EQEETMWRQEEKIREQEKKI 684
Query: 235 KDRQKKDTSQYNLEIRELERLYAHESKLKSFLLVKLNDRNEFEEQAKREEALKAKKHVKK 294
+++++K Q + + E+++ E K + + E EE+ +R+E ++ V+
Sbjct: 685 REQEEKIREQEEMMQEQEEKMWEQEEK----MCEQEEKMQEQEEKMRRQEEKMWEQEVRL 740
Query: 295 NRGE 298
+ E
Sbjct: 741 RQQE 744
Score = 42.0 bits (97), Expect = 0.002
Identities = 70/358 (19%), Positives = 158/358 (44%), Gaps = 40/358 (11%)
Query: 52 NQQKIASQYKEIKTLKTEQDEITL-LLSLMKSSRNMNRSEKNYMELRLLLQTKEDYEALI 110
++QK + Q++E + E T+ +L+ K+ M + +L + ++ L
Sbjct: 109 DEQKASHQHQEALRRELEAQVHTIRILTCQKTELQMALYYSQHAVKQLEGEARDLISRLH 168
Query: 111 KSLKVLLAELDEKILQMEKKIANQKQIFAKMQEANNPRKLQKQIHILETRLNLVTVHFDK 170
S K EL++ + +A QK+ + E +L K+ L L T+ ++
Sbjct: 169 DSWK-FAGELEQAL----SAVATQKKKADRYIE-----ELTKERDALSLELYRNTITDEE 218
Query: 171 MLTTNAKLRKEIEDLRFEKAAYDNVYQQLQHCLLMEKKTMNLAIEQSSQAYEQRVEAMAR 230
+ NAKL+++++ + EK+ ++L+ L E+ + L +Q + + +
Sbjct: 219 LKEKNAKLQEKLQLVESEKSEIQLNVKELKRKL--ERAKLLLPQQQLQAEADHLGKELQS 276
Query: 231 MAAMKDRQKKDTSQYN-LEIRELERLYAHESKLKSFLLVKLNDRNEFEEQAKREEALKAK 289
++A Q ++ +N L ++ E+++ E K++ + ++ + +E+ RE+ K +
Sbjct: 277 VSAKLQAQVEENELWNRLNQQQEEKMWRQEEKIQEW-----EEKIQEQEEKIREQEEKIR 331
Query: 290 KHVKKNRGESFESYEVAHLRLLKLAESGNLNQLIEDFLAKEEKNFARFTYVTELNNDM-- 347
+ +K R + +E + + + E KEEK + + E M
Sbjct: 332 EQEEKMRRQEEMMWE----------KEEKMRRQEEMMWEKEEKMRRQEEMMWEKEEKMRR 381
Query: 348 --EMMHKRTQRIQDEIILLRSQQKLSHDDNHSVLRQLEDKLR----KTTEEADMYESK 399
EMM ++ ++I++ + Q+K+ + RQ E+K+R + +EA M+ +
Sbjct: 382 QEEMMWEKEEKIRELEEKMHEQEKIREQEEK---RQEEEKIREQEKRQEQEAKMWRQE 436
Database: hs.faa
Posted date: Aug 4, 2009 4:42 PM
Number of letters in database: 18,247,518
Number of sequences in database: 37,866
Lambda K H
0.314 0.130 0.345
Gapped
Lambda K H
0.267 0.0410 0.140
Matrix: BLOSUM62
Gap Penalties: Existence: 11, Extension: 1
Number of Hits to DB: 18,403,556
Number of Sequences: 37866
Number of extensions: 809927
Number of successful extensions: 5794
Number of sequences better than 10.0: 30
Number of HSP's better than 10.0 without gapping: 47
Number of HSP's successfully gapped in prelim test: 676
Number of HSP's that attempted gapping in prelim test: 4240
Number of HSP's gapped (non-prelim): 1678
length of query: 563
length of database: 18,247,518
effective HSP length: 107
effective length of query: 456
effective length of database: 14,195,856
effective search space: 6473310336
effective search space used: 6473310336
T: 11
A: 40
X1: 16 ( 7.2 bits)
X2: 38 (14.6 bits)
X3: 64 (24.7 bits)
S1: 42 (22.0 bits)
S2: 65 (29.6 bits)
Search results were obtained with NCBI BLAST and RefSeq entries.
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Guide to the Human Genome
Copyright © 2010 by Stewart Scherer. All rights reserved.