Guide to the Human Genome
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Search of human proteins with 226437579

BLASTP 2.2.11 [Jun-05-2005]


Reference: Altschul, Stephen F., Thomas L. Madden, Alejandro A. Schaffer, 
Jinghui Zhang, Zheng Zhang, Webb Miller, and David J. Lipman (1997), 
"Gapped BLAST and PSI-BLAST: a new generation of protein database search
programs",  Nucleic Acids Res. 25:3389-3402.

Query= gi|226437579 NAC alpha domain containing [Homo sapiens]
         (1562 letters)

Database: hs.faa 
           37,866 sequences; 18,247,518 total letters

Searching..................................................done

                                                                 Score    E
Sequences producing significant alignments:                      (bits) Value

gi|226437579 NAC alpha domain containing [Homo sapiens]              3083   0.0  
gi|239743134 PREDICTED: NAC alpha domain containing [Homo sapiens]   3083   0.0  
gi|239754540 PREDICTED: NAC alpha domain containing [Homo sapiens]   2961   0.0  
gi|239749105 PREDICTED: NAC alpha domain containing [Homo sapiens]   2959   0.0  
gi|239508792 PREDICTED: NAC alpha domain containing [Homo sapiens]   2959   0.0  
gi|163965366 nascent polypeptide-associated complex alpha subuni...   327   7e-89
gi|163965362 nascent polypeptide-associated complex alpha subuni...   243   8e-64
gi|5031931 nascent polypeptide-associated complex alpha subunit ...   243   8e-64
gi|163965364 nascent polypeptide-associated complex alpha subuni...   243   8e-64
gi|40548328 nascent-polypeptide-associated complex alpha polypep...   222   2e-57
gi|148762969 myeloid/lymphoid or mixed-lineage leukemia 2 [Homo ...   109   2e-23
gi|91982772 mucin 17 [Homo sapiens]                                   102   4e-21
gi|239751637 PREDICTED: hypothetical protein FLJ22184 [Homo sapi...    99   4e-20
gi|132626688 mediator of DNA-damage checkpoint 1 [Homo sapiens]        98   5e-20
gi|189181724 proteoglycan 4 isoform D [Homo sapiens]                   95   6e-19
gi|189181722 proteoglycan 4 isoform C [Homo sapiens]                   95   6e-19
gi|189181720 proteoglycan 4 isoform B [Homo sapiens]                   95   6e-19
gi|67190163 proteoglycan 4 isoform A [Homo sapiens]                    95   6e-19
gi|146219843 Snf2-related CBP activator protein [Homo sapiens]         90   1e-17
gi|167736355 mucin 4 isoform a [Homo sapiens]                          89   3e-17
gi|169205253 PREDICTED: hypothetical protein [Homo sapiens]            87   1e-16
gi|150418009 transforming, acidic coiled-coil containing protein...    87   2e-16
gi|207113162 Treacher Collins-Franceschetti syndrome 1 isoform e...    86   2e-16
gi|207113160 Treacher Collins-Franceschetti syndrome 1 isoform d...    86   2e-16
gi|57164977 Treacher Collins-Franceschetti syndrome 1 isoform a ...    86   2e-16
gi|149773456 hypothetical protein LOC643314 [Homo sapiens]             85   6e-16
gi|32455273 WNK lysine deficient protein kinase 2 [Homo sapiens]       82   4e-15
gi|207113164 Treacher Collins-Franceschetti syndrome 1 isoform f...    79   3e-14
gi|57164975 Treacher Collins-Franceschetti syndrome 1 isoform b ...    79   3e-14
gi|239746149 PREDICTED: hypothetical protein LOC80164 [Homo sapi...    76   3e-13

>gi|226437579 NAC alpha domain containing [Homo sapiens]
          Length = 1562

 Score = 3083 bits (7994), Expect = 0.0
 Identities = 1562/1562 (100%), Positives = 1562/1562 (100%)

Query: 1    MPGEAARAELLLPEADRPGPRTDLSCDAAAATTILGGDRREPCALTPGPSHLALTFLPSK 60
            MPGEAARAELLLPEADRPGPRTDLSCDAAAATTILGGDRREPCALTPGPSHLALTFLPSK
Sbjct: 1    MPGEAARAELLLPEADRPGPRTDLSCDAAAATTILGGDRREPCALTPGPSHLALTFLPSK 60

Query: 61   PGARPQPEGASWDAGPGGAPSAWADPGEGGPSPMLLPEGLSSQALSTEAPLPATLEPRIV 120
            PGARPQPEGASWDAGPGGAPSAWADPGEGGPSPMLLPEGLSSQALSTEAPLPATLEPRIV
Sbjct: 61   PGARPQPEGASWDAGPGGAPSAWADPGEGGPSPMLLPEGLSSQALSTEAPLPATLEPRIV 120

Query: 121  MGEETCQALLSPRAARTALRDQEGGHASPDPPPELCSQGDLSVPSPPPDPDSFFTPPSTP 180
            MGEETCQALLSPRAARTALRDQEGGHASPDPPPELCSQGDLSVPSPPPDPDSFFTPPSTP
Sbjct: 121  MGEETCQALLSPRAARTALRDQEGGHASPDPPPELCSQGDLSVPSPPPDPDSFFTPPSTP 180

Query: 181  TKTTYALLPACGPHGDARDSEAELRDELLDSPPASPSGSYITADGDSWASSPSCSLSLLA 240
            TKTTYALLPACGPHGDARDSEAELRDELLDSPPASPSGSYITADGDSWASSPSCSLSLLA
Sbjct: 181  TKTTYALLPACGPHGDARDSEAELRDELLDSPPASPSGSYITADGDSWASSPSCSLSLLA 240

Query: 241  PAEGLDFPSGWGLSPQGSMVDERELHPAGTPEPPSSESSLSADSSSSWGQEGHFFDLDFL 300
            PAEGLDFPSGWGLSPQGSMVDERELHPAGTPEPPSSESSLSADSSSSWGQEGHFFDLDFL
Sbjct: 241  PAEGLDFPSGWGLSPQGSMVDERELHPAGTPEPPSSESSLSADSSSSWGQEGHFFDLDFL 300

Query: 301  ANDPMIPAALLPFQGSLIFQVEAVEVTPLSPEEEEEEAVADPDPGGDLAGEGEEDSTSAS 360
            ANDPMIPAALLPFQGSLIFQVEAVEVTPLSPEEEEEEAVADPDPGGDLAGEGEEDSTSAS
Sbjct: 301  ANDPMIPAALLPFQGSLIFQVEAVEVTPLSPEEEEEEAVADPDPGGDLAGEGEEDSTSAS 360

Query: 361  FLQSLSDLSITEGMDEAFAFRDDTSAASSDSDSASYAEADDERLYSGEPHAQATLLQDSV 420
            FLQSLSDLSITEGMDEAFAFRDDTSAASSDSDSASYAEADDERLYSGEPHAQATLLQDSV
Sbjct: 361  FLQSLSDLSITEGMDEAFAFRDDTSAASSDSDSASYAEADDERLYSGEPHAQATLLQDSV 420

Query: 421  QKTEEESGGGAKGLQAQDGTVSWAVEAAPQTSDRGAYLSQRQELISEVTEEGLALGQEST 480
            QKTEEESGGGAKGLQAQDGTVSWAVEAAPQTSDRGAYLSQRQELISEVTEEGLALGQEST
Sbjct: 421  QKTEEESGGGAKGLQAQDGTVSWAVEAAPQTSDRGAYLSQRQELISEVTEEGLALGQEST 480

Query: 481  ATVTPHTLQVAPGLQVEVATRVTPQAGEEETDSTAGQESAAMAMPQPSQEGISEILGQES 540
            ATVTPHTLQVAPGLQVEVATRVTPQAGEEETDSTAGQESAAMAMPQPSQEGISEILGQES
Sbjct: 481  ATVTPHTLQVAPGLQVEVATRVTPQAGEEETDSTAGQESAAMAMPQPSQEGISEILGQES 540

Query: 541  VTAEKLPTPQEETSLTLCPDSPQNLKEEGGLDLPSGRKPVAAATIVPRQAKEDLTLPQDS 600
            VTAEKLPTPQEETSLTLCPDSPQNLKEEGGLDLPSGRKPVAAATIVPRQAKEDLTLPQDS
Sbjct: 541  VTAEKLPTPQEETSLTLCPDSPQNLKEEGGLDLPSGRKPVAAATIVPRQAKEDLTLPQDS 600

Query: 601  AMTPPLPLQDTDLSSAPKPVAAATIVSQQAEEGLTLPQDSVMTPPLPLQDTELSSAPKPV 660
            AMTPPLPLQDTDLSSAPKPVAAATIVSQQAEEGLTLPQDSVMTPPLPLQDTELSSAPKPV
Sbjct: 601  AMTPPLPLQDTDLSSAPKPVAAATIVSQQAEEGLTLPQDSVMTPPLPLQDTELSSAPKPV 660

Query: 661  AAATLVSQQAEEGLTLPQDSAMTPPLPLQDTDLSSAPKPVAAATLVSQQAEEGLTLPQDS 720
            AAATLVSQQAEEGLTLPQDSAMTPPLPLQDTDLSSAPKPVAAATLVSQQAEEGLTLPQDS
Sbjct: 661  AAATLVSQQAEEGLTLPQDSAMTPPLPLQDTDLSSAPKPVAAATLVSQQAEEGLTLPQDS 720

Query: 721  AMTPPLPLQDTDLSSAPKPVAAATLVSQQAEEGLTLPQDSAMTPPLPLQDTDLSSAPKPV 780
            AMTPPLPLQDTDLSSAPKPVAAATLVSQQAEEGLTLPQDSAMTPPLPLQDTDLSSAPKPV
Sbjct: 721  AMTPPLPLQDTDLSSAPKPVAAATLVSQQAEEGLTLPQDSAMTPPLPLQDTDLSSAPKPV 780

Query: 781  AAATIVSQQAEEGLTLPQDSAMTPPLPLQDTDLSSAPKPVAAATIVSQQAEEGLTLPQDS 840
            AAATIVSQQAEEGLTLPQDSAMTPPLPLQDTDLSSAPKPVAAATIVSQQAEEGLTLPQDS
Sbjct: 781  AAATIVSQQAEEGLTLPQDSAMTPPLPLQDTDLSSAPKPVAAATIVSQQAEEGLTLPQDS 840

Query: 841  AMTPPLPLQDTDLSSAPKPVAAATPVSQQAEEGLTLPQDSAMTPPLPLQDTDLSSAPKPV 900
            AMTPPLPLQDTDLSSAPKPVAAATPVSQQAEEGLTLPQDSAMTPPLPLQDTDLSSAPKPV
Sbjct: 841  AMTPPLPLQDTDLSSAPKPVAAATPVSQQAEEGLTLPQDSAMTPPLPLQDTDLSSAPKPV 900

Query: 901  AAATPVSQQAEEGLTLPQDSAMTAPLPLQDTGPTSGPEPLAVATPQTLQAEAGCAPGTEP 960
            AAATPVSQQAEEGLTLPQDSAMTAPLPLQDTGPTSGPEPLAVATPQTLQAEAGCAPGTEP
Sbjct: 901  AAATPVSQQAEEGLTLPQDSAMTAPLPLQDTGPTSGPEPLAVATPQTLQAEAGCAPGTEP 960

Query: 961  VATMAQQEVGEALGPRPAPEEKNAALPTVPEPAALDQVQQDDPQPAAEAGTPWAAQEDAD 1020
            VATMAQQEVGEALGPRPAPEEKNAALPTVPEPAALDQVQQDDPQPAAEAGTPWAAQEDAD
Sbjct: 961  VATMAQQEVGEALGPRPAPEEKNAALPTVPEPAALDQVQQDDPQPAAEAGTPWAAQEDAD 1020

Query: 1021 STLGMEALSLPEPASGAGEEIAEALSRPGREACLEARAHTGDGAKPDSPQKETLEVENQQ 1080
            STLGMEALSLPEPASGAGEEIAEALSRPGREACLEARAHTGDGAKPDSPQKETLEVENQQ
Sbjct: 1021 STLGMEALSLPEPASGAGEEIAEALSRPGREACLEARAHTGDGAKPDSPQKETLEVENQQ 1080

Query: 1081 EGGLKPLAQEHGPRSALGGAREVPDAPPAACPEVSQARLLSPAREERGLSGKSTPEPTLP 1140
            EGGLKPLAQEHGPRSALGGAREVPDAPPAACPEVSQARLLSPAREERGLSGKSTPEPTLP
Sbjct: 1081 EGGLKPLAQEHGPRSALGGAREVPDAPPAACPEVSQARLLSPAREERGLSGKSTPEPTLP 1140

Query: 1141 SAVATEASLDSCPESSVGAVSSLDRGCPDAPAPTSAPTSQQPEPVLGLGSVEQPHEVPSV 1200
            SAVATEASLDSCPESSVGAVSSLDRGCPDAPAPTSAPTSQQPEPVLGLGSVEQPHEVPSV
Sbjct: 1141 SAVATEASLDSCPESSVGAVSSLDRGCPDAPAPTSAPTSQQPEPVLGLGSVEQPHEVPSV 1200

Query: 1201 LGTPLLQPPENLAKGQPSTPVDRPLGPDPSAPGTLAGAALPPLEPPAPCLCQDPQEDSVE 1260
            LGTPLLQPPENLAKGQPSTPVDRPLGPDPSAPGTLAGAALPPLEPPAPCLCQDPQEDSVE
Sbjct: 1201 LGTPLLQPPENLAKGQPSTPVDRPLGPDPSAPGTLAGAALPPLEPPAPCLCQDPQEDSVE 1260

Query: 1261 DEEPPGSLGLPPPQAGVQPAAAAVSGTTQPLGTGPRVSLSPHSPLLSPKVASMDAKDLAL 1320
            DEEPPGSLGLPPPQAGVQPAAAAVSGTTQPLGTGPRVSLSPHSPLLSPKVASMDAKDLAL
Sbjct: 1261 DEEPPGSLGLPPPQAGVQPAAAAVSGTTQPLGTGPRVSLSPHSPLLSPKVASMDAKDLAL 1320

Query: 1321 QILPPCQVPPPSGPQSPAGPQGLSAPEQQEDEDSLEEDSPRALGSGQHSDSHGESSAELD 1380
            QILPPCQVPPPSGPQSPAGPQGLSAPEQQEDEDSLEEDSPRALGSGQHSDSHGESSAELD
Sbjct: 1321 QILPPCQVPPPSGPQSPAGPQGLSAPEQQEDEDSLEEDSPRALGSGQHSDSHGESSAELD 1380

Query: 1381 EQDILAPQTVQCPAQAPAGGSEETIAKAKQSRSEKKARKAMSKLGLRQIQGVTRITIQKS 1440
            EQDILAPQTVQCPAQAPAGGSEETIAKAKQSRSEKKARKAMSKLGLRQIQGVTRITIQKS
Sbjct: 1381 EQDILAPQTVQCPAQAPAGGSEETIAKAKQSRSEKKARKAMSKLGLRQIQGVTRITIQKS 1440

Query: 1441 KNILFVIAKPDVFKSPASDTYVVFGEAKIEDLSQQVHKAAAEKFKVPSEPSALVPESAPR 1500
            KNILFVIAKPDVFKSPASDTYVVFGEAKIEDLSQQVHKAAAEKFKVPSEPSALVPESAPR
Sbjct: 1441 KNILFVIAKPDVFKSPASDTYVVFGEAKIEDLSQQVHKAAAEKFKVPSEPSALVPESAPR 1500

Query: 1501 PRVRLECKEEEEEEEEEVDEAGLELRDIELVMAQANVSRAKAVRALRDNHSDIVNAIMEL 1560
            PRVRLECKEEEEEEEEEVDEAGLELRDIELVMAQANVSRAKAVRALRDNHSDIVNAIMEL
Sbjct: 1501 PRVRLECKEEEEEEEEEVDEAGLELRDIELVMAQANVSRAKAVRALRDNHSDIVNAIMEL 1560

Query: 1561 TM 1562
            TM
Sbjct: 1561 TM 1562


>gi|239743134 PREDICTED: NAC alpha domain containing [Homo sapiens]
          Length = 1562

 Score = 3083 bits (7994), Expect = 0.0
 Identities = 1562/1562 (100%), Positives = 1562/1562 (100%)

Query: 1    MPGEAARAELLLPEADRPGPRTDLSCDAAAATTILGGDRREPCALTPGPSHLALTFLPSK 60
            MPGEAARAELLLPEADRPGPRTDLSCDAAAATTILGGDRREPCALTPGPSHLALTFLPSK
Sbjct: 1    MPGEAARAELLLPEADRPGPRTDLSCDAAAATTILGGDRREPCALTPGPSHLALTFLPSK 60

Query: 61   PGARPQPEGASWDAGPGGAPSAWADPGEGGPSPMLLPEGLSSQALSTEAPLPATLEPRIV 120
            PGARPQPEGASWDAGPGGAPSAWADPGEGGPSPMLLPEGLSSQALSTEAPLPATLEPRIV
Sbjct: 61   PGARPQPEGASWDAGPGGAPSAWADPGEGGPSPMLLPEGLSSQALSTEAPLPATLEPRIV 120

Query: 121  MGEETCQALLSPRAARTALRDQEGGHASPDPPPELCSQGDLSVPSPPPDPDSFFTPPSTP 180
            MGEETCQALLSPRAARTALRDQEGGHASPDPPPELCSQGDLSVPSPPPDPDSFFTPPSTP
Sbjct: 121  MGEETCQALLSPRAARTALRDQEGGHASPDPPPELCSQGDLSVPSPPPDPDSFFTPPSTP 180

Query: 181  TKTTYALLPACGPHGDARDSEAELRDELLDSPPASPSGSYITADGDSWASSPSCSLSLLA 240
            TKTTYALLPACGPHGDARDSEAELRDELLDSPPASPSGSYITADGDSWASSPSCSLSLLA
Sbjct: 181  TKTTYALLPACGPHGDARDSEAELRDELLDSPPASPSGSYITADGDSWASSPSCSLSLLA 240

Query: 241  PAEGLDFPSGWGLSPQGSMVDERELHPAGTPEPPSSESSLSADSSSSWGQEGHFFDLDFL 300
            PAEGLDFPSGWGLSPQGSMVDERELHPAGTPEPPSSESSLSADSSSSWGQEGHFFDLDFL
Sbjct: 241  PAEGLDFPSGWGLSPQGSMVDERELHPAGTPEPPSSESSLSADSSSSWGQEGHFFDLDFL 300

Query: 301  ANDPMIPAALLPFQGSLIFQVEAVEVTPLSPEEEEEEAVADPDPGGDLAGEGEEDSTSAS 360
            ANDPMIPAALLPFQGSLIFQVEAVEVTPLSPEEEEEEAVADPDPGGDLAGEGEEDSTSAS
Sbjct: 301  ANDPMIPAALLPFQGSLIFQVEAVEVTPLSPEEEEEEAVADPDPGGDLAGEGEEDSTSAS 360

Query: 361  FLQSLSDLSITEGMDEAFAFRDDTSAASSDSDSASYAEADDERLYSGEPHAQATLLQDSV 420
            FLQSLSDLSITEGMDEAFAFRDDTSAASSDSDSASYAEADDERLYSGEPHAQATLLQDSV
Sbjct: 361  FLQSLSDLSITEGMDEAFAFRDDTSAASSDSDSASYAEADDERLYSGEPHAQATLLQDSV 420

Query: 421  QKTEEESGGGAKGLQAQDGTVSWAVEAAPQTSDRGAYLSQRQELISEVTEEGLALGQEST 480
            QKTEEESGGGAKGLQAQDGTVSWAVEAAPQTSDRGAYLSQRQELISEVTEEGLALGQEST
Sbjct: 421  QKTEEESGGGAKGLQAQDGTVSWAVEAAPQTSDRGAYLSQRQELISEVTEEGLALGQEST 480

Query: 481  ATVTPHTLQVAPGLQVEVATRVTPQAGEEETDSTAGQESAAMAMPQPSQEGISEILGQES 540
            ATVTPHTLQVAPGLQVEVATRVTPQAGEEETDSTAGQESAAMAMPQPSQEGISEILGQES
Sbjct: 481  ATVTPHTLQVAPGLQVEVATRVTPQAGEEETDSTAGQESAAMAMPQPSQEGISEILGQES 540

Query: 541  VTAEKLPTPQEETSLTLCPDSPQNLKEEGGLDLPSGRKPVAAATIVPRQAKEDLTLPQDS 600
            VTAEKLPTPQEETSLTLCPDSPQNLKEEGGLDLPSGRKPVAAATIVPRQAKEDLTLPQDS
Sbjct: 541  VTAEKLPTPQEETSLTLCPDSPQNLKEEGGLDLPSGRKPVAAATIVPRQAKEDLTLPQDS 600

Query: 601  AMTPPLPLQDTDLSSAPKPVAAATIVSQQAEEGLTLPQDSVMTPPLPLQDTELSSAPKPV 660
            AMTPPLPLQDTDLSSAPKPVAAATIVSQQAEEGLTLPQDSVMTPPLPLQDTELSSAPKPV
Sbjct: 601  AMTPPLPLQDTDLSSAPKPVAAATIVSQQAEEGLTLPQDSVMTPPLPLQDTELSSAPKPV 660

Query: 661  AAATLVSQQAEEGLTLPQDSAMTPPLPLQDTDLSSAPKPVAAATLVSQQAEEGLTLPQDS 720
            AAATLVSQQAEEGLTLPQDSAMTPPLPLQDTDLSSAPKPVAAATLVSQQAEEGLTLPQDS
Sbjct: 661  AAATLVSQQAEEGLTLPQDSAMTPPLPLQDTDLSSAPKPVAAATLVSQQAEEGLTLPQDS 720

Query: 721  AMTPPLPLQDTDLSSAPKPVAAATLVSQQAEEGLTLPQDSAMTPPLPLQDTDLSSAPKPV 780
            AMTPPLPLQDTDLSSAPKPVAAATLVSQQAEEGLTLPQDSAMTPPLPLQDTDLSSAPKPV
Sbjct: 721  AMTPPLPLQDTDLSSAPKPVAAATLVSQQAEEGLTLPQDSAMTPPLPLQDTDLSSAPKPV 780

Query: 781  AAATIVSQQAEEGLTLPQDSAMTPPLPLQDTDLSSAPKPVAAATIVSQQAEEGLTLPQDS 840
            AAATIVSQQAEEGLTLPQDSAMTPPLPLQDTDLSSAPKPVAAATIVSQQAEEGLTLPQDS
Sbjct: 781  AAATIVSQQAEEGLTLPQDSAMTPPLPLQDTDLSSAPKPVAAATIVSQQAEEGLTLPQDS 840

Query: 841  AMTPPLPLQDTDLSSAPKPVAAATPVSQQAEEGLTLPQDSAMTPPLPLQDTDLSSAPKPV 900
            AMTPPLPLQDTDLSSAPKPVAAATPVSQQAEEGLTLPQDSAMTPPLPLQDTDLSSAPKPV
Sbjct: 841  AMTPPLPLQDTDLSSAPKPVAAATPVSQQAEEGLTLPQDSAMTPPLPLQDTDLSSAPKPV 900

Query: 901  AAATPVSQQAEEGLTLPQDSAMTAPLPLQDTGPTSGPEPLAVATPQTLQAEAGCAPGTEP 960
            AAATPVSQQAEEGLTLPQDSAMTAPLPLQDTGPTSGPEPLAVATPQTLQAEAGCAPGTEP
Sbjct: 901  AAATPVSQQAEEGLTLPQDSAMTAPLPLQDTGPTSGPEPLAVATPQTLQAEAGCAPGTEP 960

Query: 961  VATMAQQEVGEALGPRPAPEEKNAALPTVPEPAALDQVQQDDPQPAAEAGTPWAAQEDAD 1020
            VATMAQQEVGEALGPRPAPEEKNAALPTVPEPAALDQVQQDDPQPAAEAGTPWAAQEDAD
Sbjct: 961  VATMAQQEVGEALGPRPAPEEKNAALPTVPEPAALDQVQQDDPQPAAEAGTPWAAQEDAD 1020

Query: 1021 STLGMEALSLPEPASGAGEEIAEALSRPGREACLEARAHTGDGAKPDSPQKETLEVENQQ 1080
            STLGMEALSLPEPASGAGEEIAEALSRPGREACLEARAHTGDGAKPDSPQKETLEVENQQ
Sbjct: 1021 STLGMEALSLPEPASGAGEEIAEALSRPGREACLEARAHTGDGAKPDSPQKETLEVENQQ 1080

Query: 1081 EGGLKPLAQEHGPRSALGGAREVPDAPPAACPEVSQARLLSPAREERGLSGKSTPEPTLP 1140
            EGGLKPLAQEHGPRSALGGAREVPDAPPAACPEVSQARLLSPAREERGLSGKSTPEPTLP
Sbjct: 1081 EGGLKPLAQEHGPRSALGGAREVPDAPPAACPEVSQARLLSPAREERGLSGKSTPEPTLP 1140

Query: 1141 SAVATEASLDSCPESSVGAVSSLDRGCPDAPAPTSAPTSQQPEPVLGLGSVEQPHEVPSV 1200
            SAVATEASLDSCPESSVGAVSSLDRGCPDAPAPTSAPTSQQPEPVLGLGSVEQPHEVPSV
Sbjct: 1141 SAVATEASLDSCPESSVGAVSSLDRGCPDAPAPTSAPTSQQPEPVLGLGSVEQPHEVPSV 1200

Query: 1201 LGTPLLQPPENLAKGQPSTPVDRPLGPDPSAPGTLAGAALPPLEPPAPCLCQDPQEDSVE 1260
            LGTPLLQPPENLAKGQPSTPVDRPLGPDPSAPGTLAGAALPPLEPPAPCLCQDPQEDSVE
Sbjct: 1201 LGTPLLQPPENLAKGQPSTPVDRPLGPDPSAPGTLAGAALPPLEPPAPCLCQDPQEDSVE 1260

Query: 1261 DEEPPGSLGLPPPQAGVQPAAAAVSGTTQPLGTGPRVSLSPHSPLLSPKVASMDAKDLAL 1320
            DEEPPGSLGLPPPQAGVQPAAAAVSGTTQPLGTGPRVSLSPHSPLLSPKVASMDAKDLAL
Sbjct: 1261 DEEPPGSLGLPPPQAGVQPAAAAVSGTTQPLGTGPRVSLSPHSPLLSPKVASMDAKDLAL 1320

Query: 1321 QILPPCQVPPPSGPQSPAGPQGLSAPEQQEDEDSLEEDSPRALGSGQHSDSHGESSAELD 1380
            QILPPCQVPPPSGPQSPAGPQGLSAPEQQEDEDSLEEDSPRALGSGQHSDSHGESSAELD
Sbjct: 1321 QILPPCQVPPPSGPQSPAGPQGLSAPEQQEDEDSLEEDSPRALGSGQHSDSHGESSAELD 1380

Query: 1381 EQDILAPQTVQCPAQAPAGGSEETIAKAKQSRSEKKARKAMSKLGLRQIQGVTRITIQKS 1440
            EQDILAPQTVQCPAQAPAGGSEETIAKAKQSRSEKKARKAMSKLGLRQIQGVTRITIQKS
Sbjct: 1381 EQDILAPQTVQCPAQAPAGGSEETIAKAKQSRSEKKARKAMSKLGLRQIQGVTRITIQKS 1440

Query: 1441 KNILFVIAKPDVFKSPASDTYVVFGEAKIEDLSQQVHKAAAEKFKVPSEPSALVPESAPR 1500
            KNILFVIAKPDVFKSPASDTYVVFGEAKIEDLSQQVHKAAAEKFKVPSEPSALVPESAPR
Sbjct: 1441 KNILFVIAKPDVFKSPASDTYVVFGEAKIEDLSQQVHKAAAEKFKVPSEPSALVPESAPR 1500

Query: 1501 PRVRLECKEEEEEEEEEVDEAGLELRDIELVMAQANVSRAKAVRALRDNHSDIVNAIMEL 1560
            PRVRLECKEEEEEEEEEVDEAGLELRDIELVMAQANVSRAKAVRALRDNHSDIVNAIMEL
Sbjct: 1501 PRVRLECKEEEEEEEEEVDEAGLELRDIELVMAQANVSRAKAVRALRDNHSDIVNAIMEL 1560

Query: 1561 TM 1562
            TM
Sbjct: 1561 TM 1562


>gi|239754540 PREDICTED: NAC alpha domain containing [Homo sapiens]
          Length = 1522

 Score = 2961 bits (7676), Expect = 0.0
 Identities = 1509/1562 (96%), Positives = 1514/1562 (96%), Gaps = 40/1562 (2%)

Query: 1    MPGEAARAELLLPEADRPGPRTDLSCDAAAATTILGGDRREPCALTPGPSHLALTFLPSK 60
            MPGEAARAELLLPEADRPGPRTDLSCDAAAATTILGGDRREPCALTPGPSHLALTFLPSK
Sbjct: 1    MPGEAARAELLLPEADRPGPRTDLSCDAAAATTILGGDRREPCALTPGPSHLALTFLPSK 60

Query: 61   PGARPQPEGASWDAGPGGAPSAWADPGEGGPSPMLLPEGLSSQALSTEAPLPATLEPRIV 120
            PGARPQPEGASWDAGPGGAPSAWADPGEGGPSPMLLPEGLSSQALSTEAPLPATLEPRIV
Sbjct: 61   PGARPQPEGASWDAGPGGAPSAWADPGEGGPSPMLLPEGLSSQALSTEAPLPATLEPRIV 120

Query: 121  MGEETCQALLSPRAARTALRDQEGGHASPDPPPELCSQGDLSVPSPPPDPDSFFTPPSTP 180
            MGEETCQALLSPRAARTALRDQEGGHASPDPPPELCSQGDLSVPSPPPDPDSFFTPPSTP
Sbjct: 121  MGEETCQALLSPRAARTALRDQEGGHASPDPPPELCSQGDLSVPSPPPDPDSFFTPPSTP 180

Query: 181  TKTTYALLPACGPHGDARDSEAELRDELLDSPPASPSGSYITADGDSWASSPSCSLSLLA 240
            TKTTYALLPACGPHGDARDSEAELRDELLDSPPASPSGSYITADGDSWASSPSCSLSLLA
Sbjct: 181  TKTTYALLPACGPHGDARDSEAELRDELLDSPPASPSGSYITADGDSWASSPSCSLSLLA 240

Query: 241  PAEGLDFPSGWGLSPQGSMVDERELHPAGTPEPPSSESSLSADSSSSWGQEGHFFDLDFL 300
            PAEGLDFPSGWGLSPQGSMVDERELHPAGTPEPPSSESSLSADSSSSWGQEGHFFDLDFL
Sbjct: 241  PAEGLDFPSGWGLSPQGSMVDERELHPAGTPEPPSSESSLSADSSSSWGQEGHFFDLDFL 300

Query: 301  ANDPMIPAALLPFQGSLIFQVEAVEVTPLSPEEEEEEAVADPDPGGDLAGEGEEDSTSAS 360
            ANDPMIPAALLPFQGSLIFQVEAVEVTPLSPEEEEEEAVADPDPGGDLAGEGEEDSTSAS
Sbjct: 301  ANDPMIPAALLPFQGSLIFQVEAVEVTPLSPEEEEEEAVADPDPGGDLAGEGEEDSTSAS 360

Query: 361  FLQSLSDLSITEGMDEAFAFRDDTSAASSDSDSASYAEADDERLYSGEPHAQATLLQDSV 420
            FLQSLSDLSITEGMDEAFAFRDDTSAASSDSDSASYAEADDERLYSGEPHAQATLLQDSV
Sbjct: 361  FLQSLSDLSITEGMDEAFAFRDDTSAASSDSDSASYAEADDERLYSGEPHAQATLLQDSV 420

Query: 421  QKTEEESGGGAKGLQAQDGTVSWAVEAAPQTSDRGAYLSQRQELISEVTEEGLALGQEST 480
            QKTEEESGGGAKGLQAQDGTVSWAVEAAPQTSDRGAYLSQRQELISEVTEEGLALGQEST
Sbjct: 421  QKTEEESGGGAKGLQAQDGTVSWAVEAAPQTSDRGAYLSQRQELISEVTEEGLALGQEST 480

Query: 481  ATVTPHTLQVAPGLQVEVATRVTPQAGEEETDSTAGQESAAMAMPQPSQEGISEILGQES 540
            ATVTPHTLQVAPGLQVEVATRVTPQAGEEETDSTAGQESAAMAMPQPSQEGISEILGQES
Sbjct: 481  ATVTPHTLQVAPGLQVEVATRVTPQAGEEETDSTAGQESAAMAMPQPSQEGISEILGQES 540

Query: 541  VTAEKLPTPQEETSLTLCPDSPQNLKEEGGLDLPSGRKPVAAATIVPRQAKEDLTLPQDS 600
            VTAEKLPTPQEETSLTLCPDSPQNLKEEGGL                             
Sbjct: 541  VTAEKLPTPQEETSLTLCPDSPQNLKEEGGL----------------------------- 571

Query: 601  AMTPPLPLQDTDLSSAPKPVAAATIVSQQAEEGLTLPQDSVMTPPLPLQDTELSSAPKPV 660
                       DL S  KPVAAATIV +QAEE LTLPQDS MTPPLPLQDT+LSSAPKPV
Sbjct: 572  -----------DLPSGRKPVAAATIVPRQAEEDLTLPQDSAMTPPLPLQDTDLSSAPKPV 620

Query: 661  AAATLVSQQAEEGLTLPQDSAMTPPLPLQDTDLSSAPKPVAAATLVSQQAEEGLTLPQDS 720
            AAAT+VSQQAEEGLTLPQDS MTPPLPLQDT+LSSAPKPVAAATLVSQQAEEGLTLPQDS
Sbjct: 621  AAATIVSQQAEEGLTLPQDSVMTPPLPLQDTELSSAPKPVAAATLVSQQAEEGLTLPQDS 680

Query: 721  AMTPPLPLQDTDLSSAPKPVAAATLVSQQAEEGLTLPQDSAMTPPLPLQDTDLSSAPKPV 780
            AMTPPLPLQDTDLSSAPKPVAAATLVSQQAEEGLTLPQDSAMTPPLPLQDTDLSSAPKPV
Sbjct: 681  AMTPPLPLQDTDLSSAPKPVAAATLVSQQAEEGLTLPQDSAMTPPLPLQDTDLSSAPKPV 740

Query: 781  AAATIVSQQAEEGLTLPQDSAMTPPLPLQDTDLSSAPKPVAAATIVSQQAEEGLTLPQDS 840
            AAAT+VSQQAEEGLTLPQDSAMTPPLPLQDTDLSSAPKPVAAATIVSQQAEEGLTLPQDS
Sbjct: 741  AAATLVSQQAEEGLTLPQDSAMTPPLPLQDTDLSSAPKPVAAATIVSQQAEEGLTLPQDS 800

Query: 841  AMTPPLPLQDTDLSSAPKPVAAATPVSQQAEEGLTLPQDSAMTPPLPLQDTDLSSAPKPV 900
            AMTPPLPLQDTDLSSAPKPVAAAT VSQQAEEGLTLPQDSAMTPPLPLQDTDLSSAPKPV
Sbjct: 801  AMTPPLPLQDTDLSSAPKPVAAATLVSQQAEEGLTLPQDSAMTPPLPLQDTDLSSAPKPV 860

Query: 901  AAATPVSQQAEEGLTLPQDSAMTAPLPLQDTGPTSGPEPLAVATPQTLQAEAGCAPGTEP 960
            AAATPVSQQAEEGLTLPQDSAMTAPLPLQDTGPTSGPEPLAVATPQTLQAEAGCAPGTEP
Sbjct: 861  AAATPVSQQAEEGLTLPQDSAMTAPLPLQDTGPTSGPEPLAVATPQTLQAEAGCAPGTEP 920

Query: 961  VATMAQQEVGEALGPRPAPEEKNAALPTVPEPAALDQVQQDDPQPAAEAGTPWAAQEDAD 1020
            VATMAQQEVGEALGPRPAPEEKNAALPTVPEPAALDQVQQDDPQPAAEAGTPWAAQEDAD
Sbjct: 921  VATMAQQEVGEALGPRPAPEEKNAALPTVPEPAALDQVQQDDPQPAAEAGTPWAAQEDAD 980

Query: 1021 STLGMEALSLPEPASGAGEEIAEALSRPGREACLEARAHTGDGAKPDSPQKETLEVENQQ 1080
            STLGMEALSLPEPASGAGEEIAEALSRPGREACLEARAHTGDGAKPDSPQKETLEVENQQ
Sbjct: 981  STLGMEALSLPEPASGAGEEIAEALSRPGREACLEARAHTGDGAKPDSPQKETLEVENQQ 1040

Query: 1081 EGGLKPLAQEHGPRSALGGAREVPDAPPAACPEVSQARLLSPAREERGLSGKSTPEPTLP 1140
            EGGLKPLAQEHGPRSALGGAREVPDAPPAACPEVSQARLLSPAREERGLSGKSTPEPTLP
Sbjct: 1041 EGGLKPLAQEHGPRSALGGAREVPDAPPAACPEVSQARLLSPAREERGLSGKSTPEPTLP 1100

Query: 1141 SAVATEASLDSCPESSVGAVSSLDRGCPDAPAPTSAPTSQQPEPVLGLGSVEQPHEVPSV 1200
            SAVATEASLDSCPESSVGAVSSLDRGCPDAPAPTSAPTSQQPEPVLGLGSVEQPHEVPSV
Sbjct: 1101 SAVATEASLDSCPESSVGAVSSLDRGCPDAPAPTSAPTSQQPEPVLGLGSVEQPHEVPSV 1160

Query: 1201 LGTPLLQPPENLAKGQPSTPVDRPLGPDPSAPGTLAGAALPPLEPPAPCLCQDPQEDSVE 1260
            LGTPLLQPPENLAKGQPSTPVDRPLGPDPSAPGTLAGAALPPLEPPAPCLCQDPQEDSVE
Sbjct: 1161 LGTPLLQPPENLAKGQPSTPVDRPLGPDPSAPGTLAGAALPPLEPPAPCLCQDPQEDSVE 1220

Query: 1261 DEEPPGSLGLPPPQAGVQPAAAAVSGTTQPLGTGPRVSLSPHSPLLSPKVASMDAKDLAL 1320
            DEEPPGSLGLPPPQAGVQPAAAAVSGTTQPLGTGPRVSLSPHSPLLSPKVASMDAKDLAL
Sbjct: 1221 DEEPPGSLGLPPPQAGVQPAAAAVSGTTQPLGTGPRVSLSPHSPLLSPKVASMDAKDLAL 1280

Query: 1321 QILPPCQVPPPSGPQSPAGPQGLSAPEQQEDEDSLEEDSPRALGSGQHSDSHGESSAELD 1380
            QILPPCQVPPPSGPQSPAGPQGLSAPEQQEDEDSLEEDSPRALGSGQHSDSHGESSAELD
Sbjct: 1281 QILPPCQVPPPSGPQSPAGPQGLSAPEQQEDEDSLEEDSPRALGSGQHSDSHGESSAELD 1340

Query: 1381 EQDILAPQTVQCPAQAPAGGSEETIAKAKQSRSEKKARKAMSKLGLRQIQGVTRITIQKS 1440
            EQDILAPQTVQCPAQAPAGGSEETIAKAKQSRSEKKARKAMSKLGLRQIQGVTRITIQKS
Sbjct: 1341 EQDILAPQTVQCPAQAPAGGSEETIAKAKQSRSEKKARKAMSKLGLRQIQGVTRITIQKS 1400

Query: 1441 KNILFVIAKPDVFKSPASDTYVVFGEAKIEDLSQQVHKAAAEKFKVPSEPSALVPESAPR 1500
            KNILFVIAKPDVFKSPASDTYVVFGEAKIEDLSQQVHKAAAEKFKVPSEPSALVPESAPR
Sbjct: 1401 KNILFVIAKPDVFKSPASDTYVVFGEAKIEDLSQQVHKAAAEKFKVPSEPSALVPESAPR 1460

Query: 1501 PRVRLECKEEEEEEEEEVDEAGLELRDIELVMAQANVSRAKAVRALRDNHSDIVNAIMEL 1560
            PRVRLECKEEEEEEEEEVDEAGLELRDIELVMAQANVSRAKAVRALRDNHSDIVNAIMEL
Sbjct: 1461 PRVRLECKEEEEEEEEEVDEAGLELRDIELVMAQANVSRAKAVRALRDNHSDIVNAIMEL 1520

Query: 1561 TM 1562
            TM
Sbjct: 1521 TM 1522


>gi|239749105 PREDICTED: NAC alpha domain containing [Homo sapiens]
          Length = 1522

 Score = 2959 bits (7672), Expect = 0.0
 Identities = 1508/1562 (96%), Positives = 1514/1562 (96%), Gaps = 40/1562 (2%)

Query: 1    MPGEAARAELLLPEADRPGPRTDLSCDAAAATTILGGDRREPCALTPGPSHLALTFLPSK 60
            MPGEAARAELLLPEADRPGPRTDLSCDAAAATTILGGDRREPCALTPGPSHLALTFLPSK
Sbjct: 1    MPGEAARAELLLPEADRPGPRTDLSCDAAAATTILGGDRREPCALTPGPSHLALTFLPSK 60

Query: 61   PGARPQPEGASWDAGPGGAPSAWADPGEGGPSPMLLPEGLSSQALSTEAPLPATLEPRIV 120
            PGARPQPEGASWDAGPGGAPSAWADPGEGGPSPMLLPEGLSSQALSTEAPLPATLEPRIV
Sbjct: 61   PGARPQPEGASWDAGPGGAPSAWADPGEGGPSPMLLPEGLSSQALSTEAPLPATLEPRIV 120

Query: 121  MGEETCQALLSPRAARTALRDQEGGHASPDPPPELCSQGDLSVPSPPPDPDSFFTPPSTP 180
            MGEETCQALLSPRAARTALRDQEGGHASPDPPPELCSQGDLSVPSPPPDPDSFFTPPSTP
Sbjct: 121  MGEETCQALLSPRAARTALRDQEGGHASPDPPPELCSQGDLSVPSPPPDPDSFFTPPSTP 180

Query: 181  TKTTYALLPACGPHGDARDSEAELRDELLDSPPASPSGSYITADGDSWASSPSCSLSLLA 240
            TKTTYALLPACGPHGDARDSEAELRDELLDSPPASPSGSYITADGDSWASSPSCSLSLLA
Sbjct: 181  TKTTYALLPACGPHGDARDSEAELRDELLDSPPASPSGSYITADGDSWASSPSCSLSLLA 240

Query: 241  PAEGLDFPSGWGLSPQGSMVDERELHPAGTPEPPSSESSLSADSSSSWGQEGHFFDLDFL 300
            PAEGLDFPSGWGLSPQGSMVDERELHPAGTPEPPSSESSLSADSSSSWGQEGHFFDLDFL
Sbjct: 241  PAEGLDFPSGWGLSPQGSMVDERELHPAGTPEPPSSESSLSADSSSSWGQEGHFFDLDFL 300

Query: 301  ANDPMIPAALLPFQGSLIFQVEAVEVTPLSPEEEEEEAVADPDPGGDLAGEGEEDSTSAS 360
            ANDPMIPAALLPFQGSLIFQVEAVEVTPLSPEEEEEEAVADPDPGGDLAGEGEEDSTSAS
Sbjct: 301  ANDPMIPAALLPFQGSLIFQVEAVEVTPLSPEEEEEEAVADPDPGGDLAGEGEEDSTSAS 360

Query: 361  FLQSLSDLSITEGMDEAFAFRDDTSAASSDSDSASYAEADDERLYSGEPHAQATLLQDSV 420
            FLQSLSDLSITEGMDEAFAFRDDTSAASSDSDSASYAEADDERLYSGEPHAQATLLQDSV
Sbjct: 361  FLQSLSDLSITEGMDEAFAFRDDTSAASSDSDSASYAEADDERLYSGEPHAQATLLQDSV 420

Query: 421  QKTEEESGGGAKGLQAQDGTVSWAVEAAPQTSDRGAYLSQRQELISEVTEEGLALGQEST 480
            QKTEEESGGGAKGLQAQDGTVSWAVEAAPQTSDRGAYLSQRQELISEVTEEGLALGQEST
Sbjct: 421  QKTEEESGGGAKGLQAQDGTVSWAVEAAPQTSDRGAYLSQRQELISEVTEEGLALGQEST 480

Query: 481  ATVTPHTLQVAPGLQVEVATRVTPQAGEEETDSTAGQESAAMAMPQPSQEGISEILGQES 540
            ATVTPHTLQVAPGLQVEVATRVTPQAGEEETDSTAGQESAAMAMPQPSQEGISEILGQES
Sbjct: 481  ATVTPHTLQVAPGLQVEVATRVTPQAGEEETDSTAGQESAAMAMPQPSQEGISEILGQES 540

Query: 541  VTAEKLPTPQEETSLTLCPDSPQNLKEEGGLDLPSGRKPVAAATIVPRQAKEDLTLPQDS 600
            VTAEKLPTPQEETSLTLCPDSPQNLKEEGGL                             
Sbjct: 541  VTAEKLPTPQEETSLTLCPDSPQNLKEEGGL----------------------------- 571

Query: 601  AMTPPLPLQDTDLSSAPKPVAAATIVSQQAEEGLTLPQDSVMTPPLPLQDTELSSAPKPV 660
                       DL S  KPVAAATIV +QA+E LTLPQDS MTPPLPLQDT+LSSAPKPV
Sbjct: 572  -----------DLPSGRKPVAAATIVPRQAKEDLTLPQDSAMTPPLPLQDTDLSSAPKPV 620

Query: 661  AAATLVSQQAEEGLTLPQDSAMTPPLPLQDTDLSSAPKPVAAATLVSQQAEEGLTLPQDS 720
            AAAT+VSQQAEEGLTLPQDS MTPPLPLQDT+LSSAPKPVAAATLVSQQAEEGLTLPQDS
Sbjct: 621  AAATIVSQQAEEGLTLPQDSVMTPPLPLQDTELSSAPKPVAAATLVSQQAEEGLTLPQDS 680

Query: 721  AMTPPLPLQDTDLSSAPKPVAAATLVSQQAEEGLTLPQDSAMTPPLPLQDTDLSSAPKPV 780
            AMTPPLPLQDTDLSSAPKPVAAATLVSQQAEEGLTLPQDSAMTPPLPLQDTDLSSAPKPV
Sbjct: 681  AMTPPLPLQDTDLSSAPKPVAAATLVSQQAEEGLTLPQDSAMTPPLPLQDTDLSSAPKPV 740

Query: 781  AAATIVSQQAEEGLTLPQDSAMTPPLPLQDTDLSSAPKPVAAATIVSQQAEEGLTLPQDS 840
            AAAT+VSQQAEEGLTLPQDSAMTPPLPLQDTDLSSAPKPVAAATIVSQQAEEGLTLPQDS
Sbjct: 741  AAATLVSQQAEEGLTLPQDSAMTPPLPLQDTDLSSAPKPVAAATIVSQQAEEGLTLPQDS 800

Query: 841  AMTPPLPLQDTDLSSAPKPVAAATPVSQQAEEGLTLPQDSAMTPPLPLQDTDLSSAPKPV 900
            AMTPPLPLQDTDLSSAPKPVAAAT VSQQAEEGLTLPQDSAMTPPLPLQDTDLSSAPKPV
Sbjct: 801  AMTPPLPLQDTDLSSAPKPVAAATIVSQQAEEGLTLPQDSAMTPPLPLQDTDLSSAPKPV 860

Query: 901  AAATPVSQQAEEGLTLPQDSAMTAPLPLQDTGPTSGPEPLAVATPQTLQAEAGCAPGTEP 960
            AAATPVSQQAEEGLTLPQDSAMTAPLPLQDTGPTSGPEPLAVATPQTLQAEAGCAPGTEP
Sbjct: 861  AAATPVSQQAEEGLTLPQDSAMTAPLPLQDTGPTSGPEPLAVATPQTLQAEAGCAPGTEP 920

Query: 961  VATMAQQEVGEALGPRPAPEEKNAALPTVPEPAALDQVQQDDPQPAAEAGTPWAAQEDAD 1020
            VATMAQQEVGEALGPRPAPEEKNAALPTVPEPAALDQVQQDDPQPAAEAGTPWAAQEDAD
Sbjct: 921  VATMAQQEVGEALGPRPAPEEKNAALPTVPEPAALDQVQQDDPQPAAEAGTPWAAQEDAD 980

Query: 1021 STLGMEALSLPEPASGAGEEIAEALSRPGREACLEARAHTGDGAKPDSPQKETLEVENQQ 1080
            STLGMEALSLPEPASGAGEEIAEALSRPGREACLEARAHTGDGAKPDSPQKETLEVENQQ
Sbjct: 981  STLGMEALSLPEPASGAGEEIAEALSRPGREACLEARAHTGDGAKPDSPQKETLEVENQQ 1040

Query: 1081 EGGLKPLAQEHGPRSALGGAREVPDAPPAACPEVSQARLLSPAREERGLSGKSTPEPTLP 1140
            EGGLKPLAQEHGPRSALGGAREVPDAPPAACPEVSQARLLSPAREERGLSGKSTPEPTLP
Sbjct: 1041 EGGLKPLAQEHGPRSALGGAREVPDAPPAACPEVSQARLLSPAREERGLSGKSTPEPTLP 1100

Query: 1141 SAVATEASLDSCPESSVGAVSSLDRGCPDAPAPTSAPTSQQPEPVLGLGSVEQPHEVPSV 1200
            SAVATEASLDSCPESSVGAVSSLDRGCPDAPAPTSAPTSQQPEPVLGLGSVEQPHEVPSV
Sbjct: 1101 SAVATEASLDSCPESSVGAVSSLDRGCPDAPAPTSAPTSQQPEPVLGLGSVEQPHEVPSV 1160

Query: 1201 LGTPLLQPPENLAKGQPSTPVDRPLGPDPSAPGTLAGAALPPLEPPAPCLCQDPQEDSVE 1260
            LGTPLLQPPENLAKGQPSTPVDRPLGPDPSAPGTLAGAALPPLEPPAPCLCQDPQEDSVE
Sbjct: 1161 LGTPLLQPPENLAKGQPSTPVDRPLGPDPSAPGTLAGAALPPLEPPAPCLCQDPQEDSVE 1220

Query: 1261 DEEPPGSLGLPPPQAGVQPAAAAVSGTTQPLGTGPRVSLSPHSPLLSPKVASMDAKDLAL 1320
            DEEPPGSLGLPPPQAGVQPAAAAVSGTTQPLGTGPRVSLSPHSPLLSPKVASMDAKDLAL
Sbjct: 1221 DEEPPGSLGLPPPQAGVQPAAAAVSGTTQPLGTGPRVSLSPHSPLLSPKVASMDAKDLAL 1280

Query: 1321 QILPPCQVPPPSGPQSPAGPQGLSAPEQQEDEDSLEEDSPRALGSGQHSDSHGESSAELD 1380
            QILPPCQVPPPSGPQSPAGPQGLSAPEQQEDEDSLEEDSPRALGSGQHSDSHGESSAELD
Sbjct: 1281 QILPPCQVPPPSGPQSPAGPQGLSAPEQQEDEDSLEEDSPRALGSGQHSDSHGESSAELD 1340

Query: 1381 EQDILAPQTVQCPAQAPAGGSEETIAKAKQSRSEKKARKAMSKLGLRQIQGVTRITIQKS 1440
            EQDILAPQTVQCPAQAPAGGSEETIAKAKQSRSEKKARKAMSKLGLRQIQGVTRITIQKS
Sbjct: 1341 EQDILAPQTVQCPAQAPAGGSEETIAKAKQSRSEKKARKAMSKLGLRQIQGVTRITIQKS 1400

Query: 1441 KNILFVIAKPDVFKSPASDTYVVFGEAKIEDLSQQVHKAAAEKFKVPSEPSALVPESAPR 1500
            KNILFVIAKPDVFKSPASDTYVVFGEAKIEDLSQQVHKAAAEKFKVPSEPSALVPESAPR
Sbjct: 1401 KNILFVIAKPDVFKSPASDTYVVFGEAKIEDLSQQVHKAAAEKFKVPSEPSALVPESAPR 1460

Query: 1501 PRVRLECKEEEEEEEEEVDEAGLELRDIELVMAQANVSRAKAVRALRDNHSDIVNAIMEL 1560
            PRVRLECKEEEEEEEEEVDEAGLELRDIELVMAQANVSRAKAVRALRDNHSDIVNAIMEL
Sbjct: 1461 PRVRLECKEEEEEEEEEVDEAGLELRDIELVMAQANVSRAKAVRALRDNHSDIVNAIMEL 1520

Query: 1561 TM 1562
            TM
Sbjct: 1521 TM 1522


>gi|239508792 PREDICTED: NAC alpha domain containing [Homo sapiens]
          Length = 1522

 Score = 2959 bits (7672), Expect = 0.0
 Identities = 1508/1562 (96%), Positives = 1514/1562 (96%), Gaps = 40/1562 (2%)

Query: 1    MPGEAARAELLLPEADRPGPRTDLSCDAAAATTILGGDRREPCALTPGPSHLALTFLPSK 60
            MPGEAARAELLLPEADRPGPRTDLSCDAAAATTILGGDRREPCALTPGPSHLALTFLPSK
Sbjct: 1    MPGEAARAELLLPEADRPGPRTDLSCDAAAATTILGGDRREPCALTPGPSHLALTFLPSK 60

Query: 61   PGARPQPEGASWDAGPGGAPSAWADPGEGGPSPMLLPEGLSSQALSTEAPLPATLEPRIV 120
            PGARPQPEGASWDAGPGGAPSAWADPGEGGPSPMLLPEGLSSQALSTEAPLPATLEPRIV
Sbjct: 61   PGARPQPEGASWDAGPGGAPSAWADPGEGGPSPMLLPEGLSSQALSTEAPLPATLEPRIV 120

Query: 121  MGEETCQALLSPRAARTALRDQEGGHASPDPPPELCSQGDLSVPSPPPDPDSFFTPPSTP 180
            MGEETCQALLSPRAARTALRDQEGGHASPDPPPELCSQGDLSVPSPPPDPDSFFTPPSTP
Sbjct: 121  MGEETCQALLSPRAARTALRDQEGGHASPDPPPELCSQGDLSVPSPPPDPDSFFTPPSTP 180

Query: 181  TKTTYALLPACGPHGDARDSEAELRDELLDSPPASPSGSYITADGDSWASSPSCSLSLLA 240
            TKTTYALLPACGPHGDARDSEAELRDELLDSPPASPSGSYITADGDSWASSPSCSLSLLA
Sbjct: 181  TKTTYALLPACGPHGDARDSEAELRDELLDSPPASPSGSYITADGDSWASSPSCSLSLLA 240

Query: 241  PAEGLDFPSGWGLSPQGSMVDERELHPAGTPEPPSSESSLSADSSSSWGQEGHFFDLDFL 300
            PAEGLDFPSGWGLSPQGSMVDERELHPAGTPEPPSSESSLSADSSSSWGQEGHFFDLDFL
Sbjct: 241  PAEGLDFPSGWGLSPQGSMVDERELHPAGTPEPPSSESSLSADSSSSWGQEGHFFDLDFL 300

Query: 301  ANDPMIPAALLPFQGSLIFQVEAVEVTPLSPEEEEEEAVADPDPGGDLAGEGEEDSTSAS 360
            ANDPMIPAALLPFQGSLIFQVEAVEVTPLSPEEEEEEAVADPDPGGDLAGEGEEDSTSAS
Sbjct: 301  ANDPMIPAALLPFQGSLIFQVEAVEVTPLSPEEEEEEAVADPDPGGDLAGEGEEDSTSAS 360

Query: 361  FLQSLSDLSITEGMDEAFAFRDDTSAASSDSDSASYAEADDERLYSGEPHAQATLLQDSV 420
            FLQSLSDLSITEGMDEAFAFRDDTSAASSDSDSASYAEADDERLYSGEPHAQATLLQDSV
Sbjct: 361  FLQSLSDLSITEGMDEAFAFRDDTSAASSDSDSASYAEADDERLYSGEPHAQATLLQDSV 420

Query: 421  QKTEEESGGGAKGLQAQDGTVSWAVEAAPQTSDRGAYLSQRQELISEVTEEGLALGQEST 480
            QKTEEESGGGAKGLQAQDGTVSWAVEAAPQTSDRGAYLSQRQELISEVTEEGLALGQEST
Sbjct: 421  QKTEEESGGGAKGLQAQDGTVSWAVEAAPQTSDRGAYLSQRQELISEVTEEGLALGQEST 480

Query: 481  ATVTPHTLQVAPGLQVEVATRVTPQAGEEETDSTAGQESAAMAMPQPSQEGISEILGQES 540
            ATVTPHTLQVAPGLQVEVATRVTPQAGEEETDSTAGQESAAMAMPQPSQEGISEILGQES
Sbjct: 481  ATVTPHTLQVAPGLQVEVATRVTPQAGEEETDSTAGQESAAMAMPQPSQEGISEILGQES 540

Query: 541  VTAEKLPTPQEETSLTLCPDSPQNLKEEGGLDLPSGRKPVAAATIVPRQAKEDLTLPQDS 600
            VTAEKLPTPQEETSLTLCPDSPQNLKEEGGL                             
Sbjct: 541  VTAEKLPTPQEETSLTLCPDSPQNLKEEGGL----------------------------- 571

Query: 601  AMTPPLPLQDTDLSSAPKPVAAATIVSQQAEEGLTLPQDSVMTPPLPLQDTELSSAPKPV 660
                       DL S  KPVAAATIV +QA+E LTLPQDS MTPPLPLQDT+LSSAPKPV
Sbjct: 572  -----------DLPSGRKPVAAATIVPRQAKEDLTLPQDSAMTPPLPLQDTDLSSAPKPV 620

Query: 661  AAATLVSQQAEEGLTLPQDSAMTPPLPLQDTDLSSAPKPVAAATLVSQQAEEGLTLPQDS 720
            AAAT+VSQQAEEGLTLPQDS MTPPLPLQDT+LSSAPKPVAAATLVSQQAEEGLTLPQDS
Sbjct: 621  AAATIVSQQAEEGLTLPQDSVMTPPLPLQDTELSSAPKPVAAATLVSQQAEEGLTLPQDS 680

Query: 721  AMTPPLPLQDTDLSSAPKPVAAATLVSQQAEEGLTLPQDSAMTPPLPLQDTDLSSAPKPV 780
            AMTPPLPLQDTDLSSAPKPVAAATLVSQQAEEGLTLPQDSAMTPPLPLQDTDLSSAPKPV
Sbjct: 681  AMTPPLPLQDTDLSSAPKPVAAATLVSQQAEEGLTLPQDSAMTPPLPLQDTDLSSAPKPV 740

Query: 781  AAATIVSQQAEEGLTLPQDSAMTPPLPLQDTDLSSAPKPVAAATIVSQQAEEGLTLPQDS 840
            AAAT+VSQQAEEGLTLPQDSAMTPPLPLQDTDLSSAPKPVAAATIVSQQAEEGLTLPQDS
Sbjct: 741  AAATLVSQQAEEGLTLPQDSAMTPPLPLQDTDLSSAPKPVAAATIVSQQAEEGLTLPQDS 800

Query: 841  AMTPPLPLQDTDLSSAPKPVAAATPVSQQAEEGLTLPQDSAMTPPLPLQDTDLSSAPKPV 900
            AMTPPLPLQDTDLSSAPKPVAAAT VSQQAEEGLTLPQDSAMTPPLPLQDTDLSSAPKPV
Sbjct: 801  AMTPPLPLQDTDLSSAPKPVAAATIVSQQAEEGLTLPQDSAMTPPLPLQDTDLSSAPKPV 860

Query: 901  AAATPVSQQAEEGLTLPQDSAMTAPLPLQDTGPTSGPEPLAVATPQTLQAEAGCAPGTEP 960
            AAATPVSQQAEEGLTLPQDSAMTAPLPLQDTGPTSGPEPLAVATPQTLQAEAGCAPGTEP
Sbjct: 861  AAATPVSQQAEEGLTLPQDSAMTAPLPLQDTGPTSGPEPLAVATPQTLQAEAGCAPGTEP 920

Query: 961  VATMAQQEVGEALGPRPAPEEKNAALPTVPEPAALDQVQQDDPQPAAEAGTPWAAQEDAD 1020
            VATMAQQEVGEALGPRPAPEEKNAALPTVPEPAALDQVQQDDPQPAAEAGTPWAAQEDAD
Sbjct: 921  VATMAQQEVGEALGPRPAPEEKNAALPTVPEPAALDQVQQDDPQPAAEAGTPWAAQEDAD 980

Query: 1021 STLGMEALSLPEPASGAGEEIAEALSRPGREACLEARAHTGDGAKPDSPQKETLEVENQQ 1080
            STLGMEALSLPEPASGAGEEIAEALSRPGREACLEARAHTGDGAKPDSPQKETLEVENQQ
Sbjct: 981  STLGMEALSLPEPASGAGEEIAEALSRPGREACLEARAHTGDGAKPDSPQKETLEVENQQ 1040

Query: 1081 EGGLKPLAQEHGPRSALGGAREVPDAPPAACPEVSQARLLSPAREERGLSGKSTPEPTLP 1140
            EGGLKPLAQEHGPRSALGGAREVPDAPPAACPEVSQARLLSPAREERGLSGKSTPEPTLP
Sbjct: 1041 EGGLKPLAQEHGPRSALGGAREVPDAPPAACPEVSQARLLSPAREERGLSGKSTPEPTLP 1100

Query: 1141 SAVATEASLDSCPESSVGAVSSLDRGCPDAPAPTSAPTSQQPEPVLGLGSVEQPHEVPSV 1200
            SAVATEASLDSCPESSVGAVSSLDRGCPDAPAPTSAPTSQQPEPVLGLGSVEQPHEVPSV
Sbjct: 1101 SAVATEASLDSCPESSVGAVSSLDRGCPDAPAPTSAPTSQQPEPVLGLGSVEQPHEVPSV 1160

Query: 1201 LGTPLLQPPENLAKGQPSTPVDRPLGPDPSAPGTLAGAALPPLEPPAPCLCQDPQEDSVE 1260
            LGTPLLQPPENLAKGQPSTPVDRPLGPDPSAPGTLAGAALPPLEPPAPCLCQDPQEDSVE
Sbjct: 1161 LGTPLLQPPENLAKGQPSTPVDRPLGPDPSAPGTLAGAALPPLEPPAPCLCQDPQEDSVE 1220

Query: 1261 DEEPPGSLGLPPPQAGVQPAAAAVSGTTQPLGTGPRVSLSPHSPLLSPKVASMDAKDLAL 1320
            DEEPPGSLGLPPPQAGVQPAAAAVSGTTQPLGTGPRVSLSPHSPLLSPKVASMDAKDLAL
Sbjct: 1221 DEEPPGSLGLPPPQAGVQPAAAAVSGTTQPLGTGPRVSLSPHSPLLSPKVASMDAKDLAL 1280

Query: 1321 QILPPCQVPPPSGPQSPAGPQGLSAPEQQEDEDSLEEDSPRALGSGQHSDSHGESSAELD 1380
            QILPPCQVPPPSGPQSPAGPQGLSAPEQQEDEDSLEEDSPRALGSGQHSDSHGESSAELD
Sbjct: 1281 QILPPCQVPPPSGPQSPAGPQGLSAPEQQEDEDSLEEDSPRALGSGQHSDSHGESSAELD 1340

Query: 1381 EQDILAPQTVQCPAQAPAGGSEETIAKAKQSRSEKKARKAMSKLGLRQIQGVTRITIQKS 1440
            EQDILAPQTVQCPAQAPAGGSEETIAKAKQSRSEKKARKAMSKLGLRQIQGVTRITIQKS
Sbjct: 1341 EQDILAPQTVQCPAQAPAGGSEETIAKAKQSRSEKKARKAMSKLGLRQIQGVTRITIQKS 1400

Query: 1441 KNILFVIAKPDVFKSPASDTYVVFGEAKIEDLSQQVHKAAAEKFKVPSEPSALVPESAPR 1500
            KNILFVIAKPDVFKSPASDTYVVFGEAKIEDLSQQVHKAAAEKFKVPSEPSALVPESAPR
Sbjct: 1401 KNILFVIAKPDVFKSPASDTYVVFGEAKIEDLSQQVHKAAAEKFKVPSEPSALVPESAPR 1460

Query: 1501 PRVRLECKEEEEEEEEEVDEAGLELRDIELVMAQANVSRAKAVRALRDNHSDIVNAIMEL 1560
            PRVRLECKEEEEEEEEEVDEAGLELRDIELVMAQANVSRAKAVRALRDNHSDIVNAIMEL
Sbjct: 1461 PRVRLECKEEEEEEEEEVDEAGLELRDIELVMAQANVSRAKAVRALRDNHSDIVNAIMEL 1520

Query: 1561 TM 1562
            TM
Sbjct: 1521 TM 1522


>gi|163965366 nascent polypeptide-associated complex alpha subunit
            isoform a [Homo sapiens]
          Length = 2078

 Score =  327 bits (837), Expect = 7e-89
 Identities = 452/1602 (28%), Positives = 597/1602 (37%), Gaps = 269/1602 (16%)

Query: 82   AWADPGEGGP---SPMLLPEGLSSQALSTEAPLPATLEPRIVMGEETCQALLSPRAARTA 138
            ++A P   GP   S ++ P   +  A   E+  PA + P    G  T     SP    T 
Sbjct: 625  SYAGPDSAGPLLKSSLITP---TVAAFPLESADPAGVAPTTAKGTSTYTTTASPFLEGTV 681

Query: 139  LRDQEG-----GHASPDPPPELCSQGDLSVPSPPPDPDSFFT---PPSTPTKTTYALLPA 190
                +      G  +  P     S+     PSP        T    P  P       LP 
Sbjct: 682  SLAPKNHPVKEGTLTTLPLVPTASENCPVAPSPQNTCAPLATLVLAPEIPKSVPSPSLPP 741

Query: 191  CGPHGDARDSEAELRDELLDSPPASPSGSYITADGDSWASSPSCSLSLLAPAEGLDFPSG 250
             G     +  +       L    +SP        G S  +S   +L+ LA +     P G
Sbjct: 742  AGTPPGTKKVDGISHTSALAPVASSPKECPTEDSGASATASSKGTLTYLADSPS---PLG 798

Query: 251  WGLSPQGSMVDERELHPAGTPEPPSSESSLSADSSSSWGQEGHFFDLDFLANDPMIPAAL 310
              +SPQ             T  PP+ + S   D+       G+            +P   
Sbjct: 799  VSVSPQ-------------TKRPPTKKGSAGPDTPI-----GNLSSPVSPVEASFLPENS 840

Query: 311  LPFQGSLIFQVEAVEVTPLSPEEEEEEAVADP-DPGGDLAGEGEEDSTSASFLQSLSDLS 369
            L FQGS          TP SP+     +   P  P G      E  + S   L    +  
Sbjct: 841  LSFQGSKDSPATTHSPTPPSPKGAPTPSAVTPLSPKGVTLPPKETPTPSVVNLPFPKEGP 900

Query: 370  ITEGMDEAFAFRDDTSAASSDSDSASYAEADDERLYSGEPHAQATLLQDSVQKTEEESGG 429
             T    +A A     S  SS    A    A      S  P    T             GG
Sbjct: 901  ATPAPKQAPAL----SMTSSSPKKARATPAPKGIPASPSPKGAPT---PPAATPPSPKGG 953

Query: 430  GAKGLQAQDGTVSWAVE--AAPQTSDRGAYLSQRQELISEVTEEGLALGQESTATVTPHT 487
             A        +  WA    AA   S +G   +   +             +   AT +P  
Sbjct: 954  PATP------SPKWAPTPPAATPPSPKGGPATPSPKGAPTPPAATPPSPKGGPATPSPKG 1007

Query: 488  LQVAPGLQVEVATRVTPQAGEEETDSTAGQESAAMAMPQPSQEGISEIL----GQESVTA 543
                P +     T  +P+     T    G  +   A P PS +G         G  +  A
Sbjct: 1008 APTPPAV-----TPPSPKGSPAATPFPKGASTPPAATP-PSPKGSPAATPLPKGAPTTPA 1061

Query: 544  EKLPTPQ---EETSLTLCPDSPQNL--KEEGGLDLPSGRKPVAAATIVPRQAKEDLTLPQ 598
              LP+P+      SL   P  P       +GG   PS +         P   K  L  P 
Sbjct: 1062 ATLPSPKGGPATPSLKGAPTPPAATPPSPKGGPATPSPKGAPMPPAATPPSPKGGLATPP 1121

Query: 599  DS------AMTPPLPLQDTDLSSAPKPVAAATIVSQQAEEGLTLPQDSVMTPPLPLQDTE 652
                    A TPP P       + P P  A T  +         P+  + TPP     T 
Sbjct: 1122 HKGAPTTPAATPPSPKGGL---ATPPPKGAPTTPAATPPS----PKGGLATPPPKGAPTT 1174

Query: 653  LSSAPKPVAAATLVSQQAEEGLTLPQDSAMTPPLPLQDTDLSSAPKPVAAATLVSQ---Q 709
             ++ P P     L +   +   T P   A TPP P       + P P  A T  +     
Sbjct: 1175 PAATP-PSPKGGLATPSPKGAPTTP---AATPPSPKGGL---ATPSPKGAPTTPAATPPS 1227

Query: 710  AEEGLTLPQDS------AMTPPLPLQDTDL---SSAPKPVAAATLVSQQAEEGLTLP--- 757
             + GL  P         A TPP P           AP P AA        + GL  P   
Sbjct: 1228 PKGGLATPSPKGAPTTPAATPPSPKGGPATPPPKGAPTPPAATP---PSLKGGLATPPHK 1284

Query: 758  ---QDSAMTPPLPLQDTDLS---SAPKPVAAATIVSQQAEEGLTLPQDS----AMTPPLP 807
                 + +TPP P      S    AP P  AAT  S +   G   P+ +    A+TPP P
Sbjct: 1285 GAPNPAVVTPPSPKGGPATSPPKGAPTP-PAATPPSPKGSPGTPPPKGAPTPPAVTPPSP 1343

Query: 808  LQDTDLSSAPKPVAAATIVSQQAEEGLTLPQDS-------AMTPPLPLQDTDLSS----- 855
             + T    A  P +     +  ++EG T P  +       AMTPP P +   + S     
Sbjct: 1344 -KGTPTLPATTPSSKGGPTTPSSKEGPTPPAATPSHKGGPAMTPPSPKRGPAIPSPKGDP 1402

Query: 856  --------APKPVAAATPVSQQAEEGLTLPQDSAMTPP----LPLQDTDLSSAPKPVAAA 903
                    +PK  A ATPV++   EG   P    +TPP    + L+    +SAPK     
Sbjct: 1403 TSPAVIPLSPKK-APATPVTR---EGAATPSKGDLTPPAVTPVSLKKAPATSAPK----G 1454

Query: 904  TPVSQQAEEGLTLPQDSAMTAPLPLQDTGP----TSGPEPLAVATPQTLQAEAGCAPGTE 959
             P +  ++   TLP   A+T P P +   P    TS     A ATP  + A     P   
Sbjct: 1455 GPATPSSKGDPTLP---AVTPPSPKEPPAPKQVATSSSPKKAPATPAPMGA-----PTLP 1506

Query: 960  PVATMAQQEVGEALGPRPAPEEKNAALPTVPEPAALDQVQQDDPQPAAEAGTPWAAQEDA 1019
             V   + +EV      R  P    A L +   PA L   +   P PA    +P       
Sbjct: 1507 AVIPSSPKEVPATPSSRRDPIAPTATLLSKKTPATLAPKEALIP-PAMTVPSP------- 1558

Query: 1020 DSTLGMEALSLPEPASGAGEEIAEALSRPGREACLEARAHTGDGAKPDSPQKETLEVENQ 1079
                  +  ++P P         EA + P  +      A T    K     KE L     
Sbjct: 1559 -----KKTPAIPTPK--------EAPATPSSKEASSPPAVTPSTYKGAPSPKELL----- 1600

Query: 1080 QEGGLKPLAQEHGPRSALGGAREVPDAPPAACPEVSQARLLSPAREERGLSGKSTPEPTL 1139
                + P      P+ A          PPA  P   +    +PA +     G  T  P  
Sbjct: 1601 ----IPPAVTSPSPKEA--------PTPPAVTPPSPEKGPATPAPK-----GTPTSPPVT 1643

Query: 1140 PSAVATEASLDSCPESSVGA-VSSLDRGCPDAPAPTSAPTSQQPEPVLGLGSVEQPHEVP 1198
            PS++    +  +     +GA V    +G P    PT+               +++    P
Sbjct: 1644 PSSLKDSPTSPASVTCKMGATVPQASKGLPAKKGPTA---------------LKEVLVAP 1688

Query: 1199 SVLGTPLLQPPENLA-KGQPSTPVDRPLGPDPSAPGTLAGAALPPLEPPAPCLCQDPQED 1257
            +   TP++  P     + + S+    P+ PDPSA     G    PL   AP      Q+D
Sbjct: 1689 APESTPIITAPTRKGPQTKKSSATSPPICPDPSAKNGSKG----PLSTVAPAPLLPVQKD 1744

Query: 1258 SVE-------DEEPPGSLGLPPPQAGVQPAAAAVSGTTQPLGTGPRVSLSPHSPLLSP-- 1308
            S +          P G L  PP      P  AA      P      VS +P  P+  P  
Sbjct: 1745 SSKTAKGKDASHSPKGPLA-PPESKASTPLTAAAFEKVLPKPESASVSAAPSPPVSLPLA 1803

Query: 1309 --KVASMDAKDLALQILPPCQVPPPSGPQSPAG--------------------------P 1340
               V ++  K   L   P   +  PS P +PA                           P
Sbjct: 1804 PSPVPTLPPKQQFLPSSPGLVLESPSKPLAPADEDELLPLIPPEPISGGVPFQSVLVNMP 1863

Query: 1341 QGLSAPEQQEDEDSLEEDSPRALGSGQHSDSHGESSAELDEQDILAPQTVQCPAQAPAGG 1400
               SA        + +  +    GSG  SDS  ES  EL+EQD     T Q    A A  
Sbjct: 1864 TPKSAGIPVPTPSAKQPVTKNNKGSGTESDSD-ESVPELEEQDSTQATTQQAQLAAAAEI 1922

Query: 1401 SEETIAKAKQSRSEKKARKAMSKLGLRQIQGVTRITIQKSKNILFVIAKPDVFKSPASDT 1460
             EE ++KAKQSRSEKKARKAMSKLGLRQ+ GVTR+TI+KSKNILFVI KPDV+KSPASDT
Sbjct: 1923 DEEPVSKAKQSRSEKKARKAMSKLGLRQVTGVTRVTIRKSKNILFVITKPDVYKSPASDT 1982

Query: 1461 YVVFGEAKIEDLSQQVHKAAAEKFKVPSEPSALVPESAPRPRVRLECKEEEEEEEEEVDE 1520
            Y+VFGEAKIEDLSQQ   AAAEKFKV  E  + + E+   P V      +EE EEEEVDE
Sbjct: 1983 YIVFGEAKIEDLSQQAQLAAAEKFKVQGEAVSNIQENTQTPTV------QEESEEEEVDE 2036

Query: 1521 AGLELRDIELVMAQANVSRAKAVRALRDNHSDIVNAIMELTM 1562
             G+E++DIELVM+QANVSRAKAVRAL++N +DIVNAIMELTM
Sbjct: 2037 TGVEVKDIELVMSQANVSRAKAVRALKNNSNDIVNAIMELTM 2078



 Score =  103 bits (257), Expect = 1e-21
 Identities = 241/1020 (23%), Positives = 348/1020 (34%), Gaps = 196/1020 (19%)

Query: 474  ALGQESTATVTPHTLQVAPGLQVEVATRVTPQAGEEETDSTAGQESAAMAM-PQPSQEGI 532
            ++G        P T+  AP    EVAT V+P        +      AA+ M P   +E  
Sbjct: 435  SVGTTPLVVTNPCTIAAAPTTTFEVATCVSPPMSSGPISNIEPTSPAALVMAPVAPKEPS 494

Query: 533  SEILGQESV-TAEKLPTPQEETSLTLCPDSPQNLKEEGGLDLPSGRKPVAAATIVPRQA- 590
            +++     +  +  LP P++  +L     S   +K     DL +    +  A   P QA 
Sbjct: 495  TQVATTLRIPVSPPLPDPEDLKNL----PSSVLVKFPTQKDLQTVPASLEGAPFSPAQAG 550

Query: 591  ----KEDLTLPQDSAMTPPLPLQDTDLSSAPKPVA-AATIVSQQAEEGLTLPQD-SVMTP 644
                K+   LP   A     P   +  SS   P++  AT+  +   E L + +  S MT 
Sbjct: 551  LTTKKDPTVLPLVQAAPKNSPSFQSTSSSPEIPLSPEATLAKKSLGEPLPIGKPASSMTS 610

Query: 645  PLPLQD------TELSSAPK---PVAAATLVS--------QQAEEGLTLP-----QDSAM 682
            PL +        T+  + P    P+  ++L++        + A+     P       +  
Sbjct: 611  PLGVNSSASVIKTDSYAGPDSAGPLLKSSLITPTVAAFPLESADPAGVAPTTAKGTSTYT 670

Query: 683  TPPLPLQDTDLSSAPK--PVAAATLVS----QQAEEGLTL---PQDS-AMTPPLPLQDTD 732
            T   P  +  +S APK  PV   TL +      A E   +   PQ++ A    L L    
Sbjct: 671  TTASPFLEGTVSLAPKNHPVKEGTLTTLPLVPTASENCPVAPSPQNTCAPLATLVLAPEI 730

Query: 733  LSSAPKP--VAAATLVSQQAEEGLTLPQDSAMTP------PLPLQD-------------T 771
              S P P    A T    +  +G++    SA+ P        P +D             T
Sbjct: 731  PKSVPSPSLPPAGTPPGTKKVDGIS--HTSALAPVASSPKECPTEDSGASATASSKGTLT 788

Query: 772  DLSSAPKPVAAATI------VSQQAEEGLTLPQDSAMTPPLPLQDTDLSS---------- 815
             L+ +P P+  +         +++   G   P  +  +P  P++ + L            
Sbjct: 789  YLADSPSPLGVSVSPQTKRPPTKKGSAGPDTPIGNLSSPVSPVEASFLPENSLSFQGSKD 848

Query: 816  -----------APKPVAAATIVSQQAEEGLTLPQDSAMTP--------------PLPLQD 850
                       +PK     + V+  + +G+TLP     TP              P P Q 
Sbjct: 849  SPATTHSPTPPSPKGAPTPSAVTPLSPKGVTLPPKETPTPSVVNLPFPKEGPATPAPKQA 908

Query: 851  TDL---SSAPKPVAAATPVSQ---QAEEGLTLPQDSAMTPPLPLQDTDLSS---APKPVA 901
              L   SS+PK  A ATP  +    +      P   A TPP P       S   AP P  
Sbjct: 909  PALSMTSSSPKK-ARATPAPKGIPASPSPKGAPTPPAATPPSPKGGPATPSPKWAPTP-P 966

Query: 902  AATPVSQQAEEGLTLPQDS----AMTAPLPL---QDTGPTSGPEPLAVATPQTLQAEAGC 954
            AATP S +       P+ +    A T P P        P   P P AV  P    + A  
Sbjct: 967  AATPPSPKGGPATPSPKGAPTPPAATPPSPKGGPATPSPKGAPTPPAVTPPSPKGSPAAT 1026

Query: 955  ----APGTEPVATMAQQEVGEALGPRP--APEEKNAALPTVPEPAALDQVQQDDPQPAAE 1008
                   T P AT    +   A  P P  AP    A LP+     A   ++     PAA 
Sbjct: 1027 PFPKGASTPPAATPPSPKGSPAATPLPKGAPTTPAATLPSPKGGPATPSLKGAPTPPAAT 1086

Query: 1009 AGTPWAAQEDADSTLGMEALSLPEPASGAGEEIAEALSRPGREACLEARAHTG----DGA 1064
              +P                  P   S  G  +  A + P  +  L    H G      A
Sbjct: 1087 PPSPKGG---------------PATPSPKGAPMPPAATPPSPKGGLATPPHKGAPTTPAA 1131

Query: 1065 KPDSPQKETLEVENQQEGGLKPLAQEHGPRSALGGAREVPDAPPAACPEVSQARLLSPAR 1124
             P SP K  L     +     P A    P+  L         PP   P    A   SP  
Sbjct: 1132 TPPSP-KGGLATPPPKGAPTTPAATPPSPKGGLA------TPPPKGAPTTPAATPPSPK- 1183

Query: 1125 EERGLSGKSTPEPTLPSAVATEASLDSCPESSVGAVSSLDRGCPDAPAPTSAPTSQQPEP 1184
                  G +TP P    A  T A+    P+   G  +   +G P  PA T       P P
Sbjct: 1184 -----GGLATPSP--KGAPTTPAATPPSPKG--GLATPSPKGAPTTPAAT------PPSP 1228

Query: 1185 VLGLGSVEQPHEVPSVLGTPLLQPPENLAKGQPSTPVDR--PLGPDPSAPGTLAGAALPP 1242
              GL +   P   P+   TP   PP    KG P+TP  +  P  P  + P    G A PP
Sbjct: 1229 KGGL-ATPSPKGAPT---TPAATPPS--PKGGPATPPPKGAPTPPAATPPSLKGGLATPP 1282

Query: 1243 LE-PPAPCLCQDPQEDSVEDEEPPGSLGLPPPQAGVQPAAAAVSGTTQPLGTGPRVSLSP 1301
             +  P P +   P         PP   G P P A   P+     GT  P G     +++P
Sbjct: 1283 HKGAPNPAVVTPPSPKGGPATSPP--KGAPTPPAATPPSPKGSPGTPPPKGAPTPPAVTP 1340

Query: 1302 HSPLLSPKVASMDAKDLALQILPPCQVPPPSGPQSPAGPQGLSAPEQQEDEDSLEEDSPR 1361
             SP  +P           L    P     P+ P S  GP   +A    +   ++   SP+
Sbjct: 1341 PSPKGTP----------TLPATTPSSKGGPTTPSSKEGPTPPAATPSHKGGPAMTPPSPK 1390



 Score = 99.0 bits (245), Expect = 3e-20
 Identities = 207/892 (23%), Positives = 311/892 (34%), Gaps = 154/892 (17%)

Query: 529  QEGISEILGQESVTAEKLPTPQ-EETSLTLCPDSPQNLKEEGGLDLPSGRKPVAAATIVP 587
            Q G++ +      T   + +PQ ++T+++    SPQN    G L L     P AA ++  
Sbjct: 224  QSGVASLPQTTPTTTLAIASPQVKDTTISSVLISPQN---PGSLSLKGPVSPPAALSL-S 279

Query: 588  RQAKEDLTLPQDSA--MTPP----------LPLQDTDLSS----------APKPVAAATI 625
             Q+   +T  Q +A   TPP           PL  +   S          A       TI
Sbjct: 280  TQSLPVVTSSQKTAGPNTPPDFPISLGSHLAPLHQSSFGSVQLLGQTGPSALSDPTVKTI 339

Query: 626  VSQQAEEGLTLPQDSVMTPPLPLQDTELSSAPKPVAAATLVSQQAEEGLTLPQDSAMTPP 685
                +  G + P    + PPLP ++  +   P  VAA  +V+   ++G +       +P 
Sbjct: 340  SVDHSSTGASYPSQRSVIPPLPSRNEVV---PATVAAFPVVAPSVDKGPSTISSITCSPS 396

Query: 686  -----------LPLQDTDLSSAPKPVAAATLVSQQAEEGLTLPQDSAMTPPLPLQDTDLS 734
                        P     L S+P       LV+Q       +P  S  T PL + +    
Sbjct: 397  GSLNVATSFSLSPTTSLILKSSPNATYHYPLVAQ-------MPVSSVGTTPLVVTN---- 445

Query: 735  SAPKPVAAATLVSQQAEEGLTLPQDSAMTPPLPLQDTDLSSAPKPVAAATIVSQQAEEGL 794
              P  +AAA   + +    ++ P  S      P+ + + +S P  +  A +  ++    +
Sbjct: 446  --PCTIAAAPTTTFEVATCVSPPMSSG-----PISNIEPTS-PAALVMAPVAPKEPSTQV 497

Query: 795  TLPQDSAMTPPLPLQDTDLSSAPKPVAAATIVSQQAEEGLTLPQDSAMTPPLPLQDTDLS 854
                   ++PPLP    DL + P  V       +  +   T+P      P  P Q   L+
Sbjct: 498  ATTLRIPVSPPLP-DPEDLKNLPSSVLVKFPTQKDLQ---TVPASLEGAPFSPAQ-AGLT 552

Query: 855  SAPKPVAAATPVSQQAEEGLTLPQDSAMTPPLPLQDTDLSSAPKPVAAATPVSQQAEEGL 914
            +   P     P+ Q A +     Q ++ +P +PL   + + A K +    P+ + A    
Sbjct: 553  TKKDPTVL--PLVQAAPKNSPSFQSTSSSPEIPLSP-EATLAKKSLGEPLPIGKPA---- 605

Query: 915  TLPQDSAMTAPLPLQDT----------GPTS-GP-------EPLAVATPQTLQAEAGCAP 956
                 S+MT+PL +  +          GP S GP        P   A P      AG AP
Sbjct: 606  -----SSMTSPLGVNSSASVIKTDSYAGPDSAGPLLKSSLITPTVAAFPLESADPAGVAP 660

Query: 957  ----GTEPVATMAQQ--EVGEALGPR--PAPEEKNAALPTVPEPAALDQVQQDDPQPAAE 1008
                GT    T A    E   +L P+  P  E     LP VP  +    V        A 
Sbjct: 661  TTAKGTSTYTTTASPFLEGTVSLAPKNHPVKEGTLTTLPLVPTASENCPVAPSPQNTCAP 720

Query: 1009 AGTPWAAQEDADSTLGMEALSLPEPASGAGEEIAEALSRPGREACLEARAHTGDGAKPDS 1068
              T   A E   S   + + SLP   +  G +  + +S            HT   A   S
Sbjct: 721  LATLVLAPEIPKS---VPSPSLPPAGTPPGTKKVDGIS------------HTSALAPVAS 765

Query: 1069 PQKETLEVENQQEGGLKPLAQEHGPRSALGGAREVPDAPPAACPEVSQARLLSPAREERG 1128
              KE       ++ G    A   G  + L       D+P      VS      P +  +G
Sbjct: 766  SPKEC----PTEDSGASATASSKGTLTYLA------DSPSPLGVSVSPQTKRPPTK--KG 813

Query: 1129 LSGKSTPEPTLPSAVA-TEASLDSCPESSVGAVSSLDRGC----PDAPAPTSAPTSQQPE 1183
             +G  TP   L S V+  EAS    PE+S+    S D       P  P+P  APT     
Sbjct: 814  SAGPDTPIGNLSSPVSPVEASF--LPENSLSFQGSKDSPATTHSPTPPSPKGAPTPSAVT 871

Query: 1184 PVLGLGSVEQPHEVPSVLGTPLLQPPENLAKGQPSTPVDRP---LGPDPSAPGTLAGAAL 1240
            P+   G    P E P+     L  P E      P+TP  +    L    S+P        
Sbjct: 872  PLSPKGVTLPPKETPTPSVVNLPFPKEG-----PATPAPKQAPALSMTSSSPKKARATPA 926

Query: 1241 PPLEPPAPCLCQDPQEDSVEDEEPPGSLGLPPPQ------AGVQPAAAAVSGTTQPLGTG 1294
            P   P +P     P   +     P G    P P+      A   P+      T  P G  
Sbjct: 927  PKGIPASPSPKGAPTPPAATPPSPKGGPATPSPKWAPTPPAATPPSPKGGPATPSPKGAP 986

Query: 1295 PRVSLSPHSPLLSPKVASMDAKDLALQILPPCQVPPPSGPQSPAGPQGLSAP 1346
               + +P SP   P   S         + PP    P   P +   P+G S P
Sbjct: 987  TPPAATPPSPKGGPATPSPKGAPTPPAVTPP---SPKGSPAATPFPKGASTP 1035



 Score = 83.6 bits (205), Expect = 1e-15
 Identities = 198/966 (20%), Positives = 328/966 (33%), Gaps = 134/966 (13%)

Query: 13   PEADRPGPRTDLSCDAAAATTILGGDRREPCALTPGPSHLALTFLPSKPGARPQPEGASW 72
            P + + GP T     A     +     +   A TP P   +     + P  +  P     
Sbjct: 993  PPSPKGGPATPSPKGAPTPPAVTPPSPKGSPAATPFPKGASTPPAATPPSPKGSPAATPL 1052

Query: 73   DAGPGGAPSAWADPGEGGPSPMLL-------------PEGLSSQALSTEAPL-PATLEPR 118
              G    P+A     +GGP+   L             P+G  +      AP+ PA   P 
Sbjct: 1053 PKGAPTTPAATLPSPKGGPATPSLKGAPTPPAATPPSPKGGPATPSPKGAPMPPAATPPS 1112

Query: 119  IVMGEETCQALLSPRAARTALRDQEGGHASPDPPPELCSQGDLSVP--SPPPDPDSFFTP 176
               G  T     +P          +GG A+P P      +G  + P  +PP       TP
Sbjct: 1113 PKGGLATPPHKGAPTTPAATPPSPKGGLATPPP------KGAPTTPAATPPSPKGGLATP 1166

Query: 177  PSTPTKTTYALLPACGPHGDARDSEAELRDELLDSPPASPSGSYITADGDSWASSPSCSL 236
            P     TT A  P     G A  S          +PP SP G   T       ++P+ + 
Sbjct: 1167 PPKGAPTTPAATPPSPKGGLATPSPKGAPTTPAATPP-SPKGGLATPSPKGAPTTPAATP 1225

Query: 237  SLLAPAEGLDFPSGWGL---------SPQGSMVDERELHPAGTPEPPSSESSLSADSSSS 287
               +P  GL  PS  G          SP+G         P G P PP++         ++
Sbjct: 1226 P--SPKGGLATPSPKGAPTTPAATPPSPKGGPATP---PPKGAPTPPAATPPSLKGGLAT 1280

Query: 288  WGQEGHFFDLDFLANDPMIPAALLPFQGSLIFQVEAVEVTPLSPEEEEEEAVADPDPGG- 346
               +G        A +P +     P  G      +     P +     + +   P P G 
Sbjct: 1281 PPHKG--------APNPAVVTPPSPKGGPATSPPKGAPTPPAATPPSPKGSPGTPPPKGA 1332

Query: 347  ---------DLAGEGEEDSTSASFLQSLSDLSITEGMDEAFAFRDDTSAASSDSDSASYA 397
                        G     +T+ S     +  S  EG     A        +    S    
Sbjct: 1333 PTPPAVTPPSPKGTPTLPATTPSSKGGPTTPSSKEGPTPPAATPSHKGGPAMTPPSPKRG 1392

Query: 398  EADDERLYSGEPHAQATL-----LQDSVQKTEEESGGGAKGLQAQDGTVSWAVEAAPQTS 452
             A       G+P + A +        +   T E +   +KG          +++ AP TS
Sbjct: 1393 PAIPSP--KGDPTSPAVIPLSPKKAPATPVTREGAATPSKGDLTPPAVTPVSLKKAPATS 1450

Query: 453  -DRGAYLSQRQELISEVTEEGLALGQESTATVTPHTLQVAPGLQVEVATRVTPQAGEEET 511
              +G   +   +            G  +   VTP + +  P  + +VAT  +P+     T
Sbjct: 1451 APKGGPATPSSK------------GDPTLPAVTPPSPKEPPAPK-QVATSSSPKKA-PAT 1496

Query: 512  DSTAGQESAAMAMPQPSQEGISEILGQESVTAEKLPTPQEETSLTLCPDSPQNLKEEGGL 571
             +  G  +    +P   +E  +    +    A       ++T  TL   +P+       +
Sbjct: 1497 PAPMGAPTLPAVIPSSPKEVPATPSSRRDPIAPTATLLSKKTPATL---APKEALIPPAM 1553

Query: 572  DLPSGRKPVAAATIVPRQAKEDLTLPQDSAMTPPLPLQDTDLSSAPKPVAAATIVSQQAE 631
             +PS +K  A  T            P+++  TP      +  +S+P  V  +T     + 
Sbjct: 1554 TVPSPKKTPAIPT------------PKEAPATP-----SSKEASSPPAVTPSTYKGAPSP 1596

Query: 632  EGLTLPQDSVMTPPLPLQDTELSSAPKPVAAATLVSQQAEEGLTLPQDSAMTPPLPLQDT 691
            + L +P    +T P P        AP P A   +     E+G   P         P+  +
Sbjct: 1597 KELLIP--PAVTSPSP------KEAPTPPA---VTPPSPEKGPATPAPKGTPTSPPVTPS 1645

Query: 692  DLSSAPKPVAAATLVSQQAEEGLTLPQDSAMTP----PLPLQDTDLSSAPKPVAAATLVS 747
             L  +P   A+ T      + G T+PQ S   P    P  L++  ++ AP+   +  +++
Sbjct: 1646 SLKDSPTSPASVT-----CKMGATVPQASKGLPAKKGPTALKEVLVAPAPE---STPIIT 1697

Query: 748  QQAEEGLTLPQDSAMTPPLPLQDTDLSSAPKP---VAAATIVSQQAEEGLTLP-QDSAMT 803
                +G    + SA +PP+    +  + +  P   VA A ++  Q +   T   +D++ +
Sbjct: 1698 APTRKGPQTKKSSATSPPICPDPSAKNGSKGPLSTVAPAPLLPVQKDSSKTAKGKDASHS 1757

Query: 804  PPLPLQDTDLSSAPKPVAAATIVSQQAEEGLTLPQDSAMTPPLPLQDTDLSSAPKPVAAA 863
            P  PL       AP    A+T ++  A E +    +SA     P     L  AP PV   
Sbjct: 1758 PKGPL-------APPESKASTPLTAAAFEKVLPKPESASVSAAPSPPVSLPLAPSPVPTL 1810

Query: 864  TPVSQQAEEGLTLPQDSAMTPPLPLQDTDLSS--APKPVAAATPVSQQAEEGLTLPQDSA 921
             P  Q       L  +S   P  P  + +L     P+P++   P  Q     +  P+ + 
Sbjct: 1811 PPKQQFLPSSPGLVLESPSKPLAPADEDELLPLIPPEPISGGVPF-QSVLVNMPTPKSAG 1869

Query: 922  MTAPLP 927
            +  P P
Sbjct: 1870 IPVPTP 1875



 Score = 53.5 bits (127), Expect = 2e-06
 Identities = 126/537 (23%), Positives = 197/537 (36%), Gaps = 83/537 (15%)

Query: 836  LPQDSAMTPPLPLQDTDLSSAPKPVAAATPVSQQAEEGLTLPQDSAMTPP-LPLQDTDLS 894
            LPQ  A T  LP+     SSA    AA        + G TLP   +  P   PL   + +
Sbjct: 16   LPQPQAETAVLPM-----SSALSVTAAL------GQPGPTLPPPCSPAPQQCPLSAANQA 64

Query: 895  SA-PKP-VAAATPVS---QQAEEGLTLPQDSAMTAPLPLQDT-GPTSGPEPLAVATPQTL 948
            S  P P   A+TP+     Q+  G  LP  +A  AP  L +  GP   P  LA+A+P   
Sbjct: 65   SPFPSPSTIASTPLEVPFPQSSSGTALPLGTAPEAPTFLPNLIGPPISPAALALASPMIA 124

Query: 949  QAEAGCAPGTEPVATMAQQEVGEALGPRPAPEEKNAALP----TVPEPAALDQVQQDDPQ 1004
                G    + P+A +A           P   +K++A P    T P   A+         
Sbjct: 125  PTLKGTPSSSAPLALVAL---------APHSVQKSSAFPPNLLTSPPSVAV--------- 166

Query: 1005 PAAEAGT------PWAAQEDADSTLGMEALSLPEPASGAGEEIAEALSRPGREACLEARA 1058
              AE+G+      P A  E   +   + +  +P P  G         + P       A  
Sbjct: 167  --AESGSVITLSAPIAPSEPKTNLNKVPSEVVPNP-KGTPSPPCIVSTVPYHCVTPMASI 223

Query: 1059 HTGDGAKPDSPQKETLEVENQQEGGLKPLAQEHGPRSALGGAREVPDAPPAACPEVSQAR 1118
             +G  + P +    TL + + Q       +    P++    + + P +PPAA    +Q+ 
Sbjct: 224  QSGVASLPQTTPTTTLAIASPQVKDTTISSVLISPQNPGSLSLKGPVSPPAALSLSTQS- 282

Query: 1119 LLSPAREERGLSGKSTPEPTLPSAVATEASLDSCPESSVGAVSSLDRGCPDAPAPTSAPT 1178
             L      +  +G +TP P  P  ++  + L    +SS G+V  L +  P A +  +  T
Sbjct: 283  -LPVVTSSQKTAGPNTP-PDFP--ISLGSHLAPLHQSSFGSVQLLGQTGPSALSDPTVKT 338

Query: 1179 SQQPEPVLGLGSVEQPHEVPSVLGTPLLQPPENLAKGQPSTPVDRPLGPDP------SAP 1232
                    G     Q   +P +     + P    A    +  VD+  GP        S  
Sbjct: 339  ISVDHSSTGASYPSQRSVIPPLPSRNEVVPATVAAFPVVAPSVDK--GPSTISSITCSPS 396

Query: 1233 GTLAGAALPPLEPPAPCLCQDPQEDS----VEDEEPPGSLGLPPPQAGVQPAAAAVSGTT 1288
            G+L  A    L P    + +     +    +  + P  S+G   P     P   A + TT
Sbjct: 397  GSLNVATSFSLSPTTSLILKSSPNATYHYPLVAQMPVSSVG-TTPLVVTNPCTIAAAPTT 455

Query: 1289 ---------QPLGTGPRVSLSPHSPL------LSPKVASMD-AKDLALQILPPCQVP 1329
                      P+ +GP  ++ P SP       ++PK  S   A  L + + PP   P
Sbjct: 456  TFEVATCVSPPMSSGPISNIEPTSPAALVMAPVAPKEPSTQVATTLRIPVSPPLPDP 512



 Score = 46.2 bits (108), Expect = 2e-04
 Identities = 68/283 (24%), Positives = 93/283 (32%), Gaps = 42/283 (14%)

Query: 18   PGPRTDLSCDAAAATTILGGDRREPCALTPGPSHLALTFLPSKPGARPQPEGASWDAGPG 77
            P P+   +  AA   +  GG         P P  +        P A P P+GAS      
Sbjct: 980  PSPKGAPTPPAATPPSPKGGPATPSPKGAPTPPAVTPPSPKGSPAATPFPKGAS------ 1033

Query: 78   GAPSAWADPGEGGPSPMLLPEGLSSQALSTEAPLPATLEPRIVMGEETCQALLSPRAART 137
              P+A     +G P+   LP+G  +         PA   P    G  T     +P     
Sbjct: 1034 TPPAATPPSPKGSPAATPLPKGAPT--------TPAATLPSPKGGPATPSLKGAPTPPAA 1085

Query: 138  ALRDQEGGHASPDP-----PPELCSQGDLSVPSPPPDPDSFFTPPSTPTKTTYALLPACG 192
                 +GG A+P P     PP           +PP       TPP     TT A  P   
Sbjct: 1086 TPPSPKGGPATPSPKGAPMPP---------AATPPSPKGGLATPPHKGAPTTPAATPP-S 1135

Query: 193  PHGDARDSEAELRDELLDSPPASPSGSYITADGDSWASSPSCSLSLLAPAEGLDFPSGWG 252
            P G       +       + P SP G   T       ++P+ +    +P  GL  PS  G
Sbjct: 1136 PKGGLATPPPKGAPTTPAATPPSPKGGLATPPPKGAPTTPAATPP--SPKGGLATPSPKG 1193

Query: 253  L---------SPQGSMVDERELHPAGTP--EPPSSESSLSADS 284
                      SP+G +          TP   PPS +  L+  S
Sbjct: 1194 APTTPAATPPSPKGGLATPSPKGAPTTPAATPPSPKGGLATPS 1236



 Score = 43.5 bits (101), Expect = 0.002
 Identities = 61/240 (25%), Positives = 83/240 (34%), Gaps = 42/240 (17%)

Query: 46   TPGPSH---LALTFL-PSKPGARPQPEGASWDAGPGGAPSAWADPGEGGPSPMLLPEGLS 101
            TP P     L++T   P K  A P P+G      P GAP+    P    PSP   P   S
Sbjct: 902  TPAPKQAPALSMTSSSPKKARATPAPKGIPASPSPKGAPT---PPAATPPSPKGGPATPS 958

Query: 102  SQALSTEAPLPATLEPRIVMGEETCQALLSPRAARTALRDQEGGHASPDP-----PPELC 156
             +   T    PA   P    G  T     +P          +GG A+P P     PP + 
Sbjct: 959  PKWAPTP---PAATPPSPKGGPATPSPKGAPTPPAATPPSPKGGPATPSPKGAPTPPAVT 1015

Query: 157  SQGDLSVPSPPPDPDSFFTPPSTPTKTTYALLPACGPHGDARDSEAELRDELLDSPPASP 216
                   P+  P P    TPP+  T  +    PA  P              L    P +P
Sbjct: 1016 PPSPKGSPAATPFPKGASTPPAA-TPPSPKGSPAATP--------------LPKGAPTTP 1060

Query: 217  SGSYITADGDSWASSPSCSLSLLAPAEGLDFPSGWGLSPQGSMVDERELHPAGTPEPPSS 276
            + +  +  G    ++PS   +   PA     P G   +P           P G P PP++
Sbjct: 1061 AATLPSPKGG--PATPSLKGAPTPPAATPPSPKGGPATPS----------PKGAPMPPAA 1108



 Score = 42.4 bits (98), Expect = 0.004
 Identities = 55/207 (26%), Positives = 78/207 (37%), Gaps = 19/207 (9%)

Query: 1136 EPTLPSAVATEASLDSCPESSVGAVSSLDRGCPDAPAPTSAPTSQQPEPVLGLGSVEQPH 1195
            E  LP   A  A L     S++   ++L +  P  P P S    Q P   L   +   P 
Sbjct: 13   EQELPQPQAETAVLPM--SSALSVTAALGQPGPTLPPPCSPAPQQCP---LSAANQASPF 67

Query: 1196 EVPSVLGTPLLQPPENLAKGQPSTPVDRPLGPDPSAPGTLAGAALPPLEPPAPCLCQD-- 1253
              PS + +  L+ P      Q S+    PLG  P AP  L     PP+ P A  L     
Sbjct: 68   PSPSTIASTPLEVPFP----QSSSGTALPLGTAPEAPTFLPNLIGPPISPAALALASPMI 123

Query: 1254 -PQEDSVEDEEPPGSLGLPPPQAGVQPAAAAVSGTTQPLGTGPRVSLSPHSPL--LSPKV 1310
             P          P +L    P +  + +A   +  T P    P V+++    +  LS  +
Sbjct: 124  APTLKGTPSSSAPLALVALAPHSVQKSSAFPPNLLTSP----PSVAVAESGSVITLSAPI 179

Query: 1311 ASMDAKDLALQILPPCQVPPPSGPQSP 1337
            A  + K   L  +P   VP P G  SP
Sbjct: 180  APSEPK-TNLNKVPSEVVPNPKGTPSP 205


>gi|163965362 nascent polypeptide-associated complex alpha subunit
            isoform b [Homo sapiens]
          Length = 215

 Score =  243 bits (621), Expect = 8e-64
 Identities = 139/219 (63%), Positives = 162/219 (73%), Gaps = 10/219 (4%)

Query: 1347 EQQEDEDSLEEDSPRA---LGSGQHSDSHGESSAELDEQDILAPQTVQCPAQAPAGGSEE 1403
            E  E   + E++ P+     GSG  SDS  ES  EL+EQD     T Q    A A   EE
Sbjct: 4    EATETVPATEQELPQPQAETGSGTESDSD-ESVPELEEQDSTQATTQQAQLAAAAEIDEE 62

Query: 1404 TIAKAKQSRSEKKARKAMSKLGLRQIQGVTRITIQKSKNILFVIAKPDVFKSPASDTYVV 1463
             ++KAKQSRSEKKARKAMSKLGLRQ+ GVTR+TI+KSKNILFVI KPDV+KSPASDTY+V
Sbjct: 63   PVSKAKQSRSEKKARKAMSKLGLRQVTGVTRVTIRKSKNILFVITKPDVYKSPASDTYIV 122

Query: 1464 FGEAKIEDLSQQVHKAAAEKFKVPSEPSALVPESAPRPRVRLECKEEEEEEEEEVDEAGL 1523
            FGEAKIEDLSQQ   AAAEKFKV  E  + + E+   P V      +EE EEEEVDE G+
Sbjct: 123  FGEAKIEDLSQQAQLAAAEKFKVQGEAVSNIQENTQTPTV------QEESEEEEVDETGV 176

Query: 1524 ELRDIELVMAQANVSRAKAVRALRDNHSDIVNAIMELTM 1562
            E++DIELVM+QANVSRAKAVRAL++N +DIVNAIMELTM
Sbjct: 177  EVKDIELVMSQANVSRAKAVRALKNNSNDIVNAIMELTM 215


>gi|5031931 nascent polypeptide-associated complex alpha subunit
            isoform b [Homo sapiens]
          Length = 215

 Score =  243 bits (621), Expect = 8e-64
 Identities = 139/219 (63%), Positives = 162/219 (73%), Gaps = 10/219 (4%)

Query: 1347 EQQEDEDSLEEDSPRA---LGSGQHSDSHGESSAELDEQDILAPQTVQCPAQAPAGGSEE 1403
            E  E   + E++ P+     GSG  SDS  ES  EL+EQD     T Q    A A   EE
Sbjct: 4    EATETVPATEQELPQPQAETGSGTESDSD-ESVPELEEQDSTQATTQQAQLAAAAEIDEE 62

Query: 1404 TIAKAKQSRSEKKARKAMSKLGLRQIQGVTRITIQKSKNILFVIAKPDVFKSPASDTYVV 1463
             ++KAKQSRSEKKARKAMSKLGLRQ+ GVTR+TI+KSKNILFVI KPDV+KSPASDTY+V
Sbjct: 63   PVSKAKQSRSEKKARKAMSKLGLRQVTGVTRVTIRKSKNILFVITKPDVYKSPASDTYIV 122

Query: 1464 FGEAKIEDLSQQVHKAAAEKFKVPSEPSALVPESAPRPRVRLECKEEEEEEEEEVDEAGL 1523
            FGEAKIEDLSQQ   AAAEKFKV  E  + + E+   P V      +EE EEEEVDE G+
Sbjct: 123  FGEAKIEDLSQQAQLAAAEKFKVQGEAVSNIQENTQTPTV------QEESEEEEVDETGV 176

Query: 1524 ELRDIELVMAQANVSRAKAVRALRDNHSDIVNAIMELTM 1562
            E++DIELVM+QANVSRAKAVRAL++N +DIVNAIMELTM
Sbjct: 177  EVKDIELVMSQANVSRAKAVRALKNNSNDIVNAIMELTM 215


>gi|163965364 nascent polypeptide-associated complex alpha subunit
            isoform b [Homo sapiens]
          Length = 215

 Score =  243 bits (621), Expect = 8e-64
 Identities = 139/219 (63%), Positives = 162/219 (73%), Gaps = 10/219 (4%)

Query: 1347 EQQEDEDSLEEDSPRA---LGSGQHSDSHGESSAELDEQDILAPQTVQCPAQAPAGGSEE 1403
            E  E   + E++ P+     GSG  SDS  ES  EL+EQD     T Q    A A   EE
Sbjct: 4    EATETVPATEQELPQPQAETGSGTESDSD-ESVPELEEQDSTQATTQQAQLAAAAEIDEE 62

Query: 1404 TIAKAKQSRSEKKARKAMSKLGLRQIQGVTRITIQKSKNILFVIAKPDVFKSPASDTYVV 1463
             ++KAKQSRSEKKARKAMSKLGLRQ+ GVTR+TI+KSKNILFVI KPDV+KSPASDTY+V
Sbjct: 63   PVSKAKQSRSEKKARKAMSKLGLRQVTGVTRVTIRKSKNILFVITKPDVYKSPASDTYIV 122

Query: 1464 FGEAKIEDLSQQVHKAAAEKFKVPSEPSALVPESAPRPRVRLECKEEEEEEEEEVDEAGL 1523
            FGEAKIEDLSQQ   AAAEKFKV  E  + + E+   P V      +EE EEEEVDE G+
Sbjct: 123  FGEAKIEDLSQQAQLAAAEKFKVQGEAVSNIQENTQTPTV------QEESEEEEVDETGV 176

Query: 1524 ELRDIELVMAQANVSRAKAVRALRDNHSDIVNAIMELTM 1562
            E++DIELVM+QANVSRAKAVRAL++N +DIVNAIMELTM
Sbjct: 177  EVKDIELVMSQANVSRAKAVRALKNNSNDIVNAIMELTM 215


>gi|40548328 nascent-polypeptide-associated complex alpha
            polypeptide-like [Homo sapiens]
          Length = 215

 Score =  222 bits (566), Expect = 2e-57
 Identities = 128/219 (58%), Positives = 157/219 (71%), Gaps = 10/219 (4%)

Query: 1347 EQQEDEDSLEEDSPRA---LGSGQHSDSHGESSAELDEQDILAPQTVQCPAQAPAGGSEE 1403
            E  E   + E++ P++    GSG  SDS GES   ++EQD     T +    A A   EE
Sbjct: 4    EATETVPATEQELPQSQAETGSGTASDS-GESVPGIEEQDSTQTTTQKAWLVAAAEIDEE 62

Query: 1404 TIAKAKQSRSEKKARKAMSKLGLRQIQGVTRITIQKSKNILFVIAKPDVFKSPASDTYVV 1463
             + KAKQSRSEK+ARKAMSKLGL Q+ GVTR+TI KSKNILFVI K DV+KSPASD Y+V
Sbjct: 63   PVGKAKQSRSEKRARKAMSKLGLLQVTGVTRVTIWKSKNILFVITKLDVYKSPASDAYIV 122

Query: 1464 FGEAKIEDLSQQVHKAAAEKFKVPSEPSALVPESAPRPRVRLECKEEEEEEEEEVDEAGL 1523
            FGEAKI+DLSQQ   AAAEKF+V  E    + E+   P V      +EE EEEEVDE G+
Sbjct: 123  FGEAKIQDLSQQAQLAAAEKFRVQGEAVGNIQENTQTPTV------QEESEEEEVDETGV 176

Query: 1524 ELRDIELVMAQANVSRAKAVRALRDNHSDIVNAIMELTM 1562
            E++D++LVM+QANVSRAKAVRAL++N +DIVNAIMELT+
Sbjct: 177  EVKDVKLVMSQANVSRAKAVRALKNNSNDIVNAIMELTV 215


>gi|148762969 myeloid/lymphoid or mixed-lineage leukemia 2 [Homo
            sapiens]
          Length = 5537

 Score =  109 bits (272), Expect = 2e-23
 Identities = 210/865 (24%), Positives = 309/865 (35%), Gaps = 142/865 (16%)

Query: 597  PQDSAMTPPLPLQDTDLSSAPKPVAAATIVSQQAEEGLTLPQDSVMTPPLPLQDTELSSA 656
            P  S  +PP P         P     A  V+ Q +     P+   +T   P +   L   
Sbjct: 367  PVCSRFSPPEP------GDTPTDEPDALYVACQGQ-----PKGGHVTSMQPKEPGPLQCE 415

Query: 657  PKPVAAATLVSQQAEEGLTLPQDSAMTPPLPLQDTDLSSAPK-----PVAAATLVSQQAE 711
             KP+  A +   Q E  L  P +  M    P +++ LS  P+     P   A+ +S   E
Sbjct: 416  AKPLGKAGV---QLEPQLEAPLNEEMPLLPPPEESPLSPPPEESPTSPPPEASRLSPPPE 472

Query: 712  EGLTLPQDSAMTPPLPLQDTDLSSAPK-----PVAAATLVSQQAEEGLTLPQDSAMTPPL 766
            E    P   A+    PL+++ LS  P+     P   ++  S   E  L+ P++S   PP 
Sbjct: 473  ELPASPLPEALHLSRPLEESPLSPPPEESPLSPPPESSPFSPLEESPLSPPEES---PPS 529

Query: 767  PLQDTDLSSAPKPVAAATIVSQQAEEGLTLPQDSAMTPPLPLQDTDLSSAPKPVAAATIV 826
            P  +T LS  P+    A+ +S   EE       S ++PP      +L ++P P A+    
Sbjct: 530  PALETPLSPPPE----ASPLSPPFEE-------SPLSPP----PEELPTSPPPEASRLSP 574

Query: 827  SQQAEEGLTLPQDSAMTPPL-------PLQDTDLSSAPKPVAAATPVSQQAEEGLTLPQD 879
              +       P++S M+PP        P +++ LS  P+    + P   +A      P+D
Sbjct: 575  PPEESPMSPPPEESPMSPPPEASRLFPPFEESPLSPPPEESPLSPP--PEASRLSPPPED 632

Query: 880  SAMTPPL-------PLQDTDLSSAP-----KPVAAATPVSQQAEEGLTLPQDSAMTAPLP 927
            S M+PP        P + + LS  P      P    +P+S   EE  T P   A     P
Sbjct: 633  SPMSPPPEESPMSPPPEVSRLSPLPVVSRLSPPPEESPLSPPPEESPTSPPPEASRLSPP 692

Query: 928  LQDTGPTSGPEPLAVATPQTLQAEAGCAPGTEPVATMAQ--QEVGEALGPR--PAPEEKN 983
             +D+ PTS P   + A+P    +         P+  + +  Q    + GP   P PEE +
Sbjct: 693  PEDS-PTSPPPEDSPASPPPEDSLMSLPLEESPLLPLPEEPQLCPRSEGPHLSPRPEEPH 751

Query: 984  AALPTVPEPAALDQVQQDDPQPAAEAGTPWAAQEDADSTLGMEALSL---PEPASGAGEE 1040
             + P   EP    Q ++    P  E     A  E+   +   E   L   PE    + + 
Sbjct: 752  LS-PRPEEPHLSPQAEEPHLSPQPEEPCLCAVPEEPHLSPQAEGPHLSPQPEELHLSPQT 810

Query: 1041 IAEALSRPGREACLEARAHTGDGAKPDSPQKETLEVENQ-QEGGLKPLAQEHG-----PR 1094
                LS    E CL             SPQ E   +  Q +E  L P  +E        +
Sbjct: 811  EEPHLSPVPEEPCL-------------SPQPEESHLSPQSEEPCLSPRPEESHLSPELEK 857

Query: 1095 SALGGAREVPDAPPAACPEVSQARLLSPAREERGLSGKSTPEPTLPSAVATEASLDSCPE 1154
              L    E P   P  CP   +  L  P  E         P  + P         +  P 
Sbjct: 858  PPLSPRPEKPPEEPGQCPAPEELPLFPPPGEPSLSPLLGEPALSEPGEPPLSPLPEELPL 917

Query: 1155 SSVGAVSSLDRGCPDAPAPTSAP---TSQQPEPVLGLGSVEQPH--------EVP---SV 1200
            S  G  S   +  P  P P       T+  P  +  LG +E P         E P    +
Sbjct: 918  SPSGEPSLSPQLMPPDPLPPPLSPIITAAAPPALSPLGELEYPFGAKGDSDPESPLAAPI 977

Query: 1201 LGTPLLQPPE-NLAKGQPSTPVDRPLGPDPSAPGTLAGAALPPLEPPAPCLCQDPQEDSV 1259
            L TP+  PPE N    +P  P+  P      +PG+  G A P L  P P  C    + S+
Sbjct: 978  LETPISPPPEANCTDPEPVPPMILP-----PSPGSPVGPASPILMEPLPPQCSPLLQHSL 1032

Query: 1260 EDEEPPGSLGLPPPQAGVQPAAAAVSGTTQPLGTGPRVSLSPHSPLLSPKVASMDAKDLA 1319
              +  P S   PP          +V     P+  G  V +S  + L   +   +      
Sbjct: 1033 VPQNSPPSQCSPP------ALPLSVPSPLSPI--GKVVGVSDEAELHEMETEKVSE---- 1080

Query: 1320 LQILPPCQVPPPSGPQSPAGPQG-LSAPEQQEDEDSLEEDSPRALGSGQHSDSHGESSAE 1378
                P C    PS       P G LS P            +P    +       GE +A 
Sbjct: 1081 ----PECPALEPSATSPLPSPMGDLSCP------------APSPAPALDDFSGLGEDTAP 1124

Query: 1379 LDEQDILAPQTVQCPAQAPAGGSEE 1403
            LD  D  AP +   P Q P   + E
Sbjct: 1125 LDGID--APGSQPEPGQTPGSLASE 1147



 Score = 70.9 bits (172), Expect = 9e-12
 Identities = 221/931 (23%), Positives = 324/931 (34%), Gaps = 162/931 (17%)

Query: 503  TPQAGEEETDSTAGQESAAMAMPQPSQEGISEILGQESVTAEKLPTPQEETSLTLCPDSP 562
            +P +  EE+  +   E+     P+ S           S   E+LPT     +  L P   
Sbjct: 518  SPLSPPEESPPSPALETPLSPPPEASPLSPPFEESPLSPPPEELPTSPPPEASRLSPPPE 577

Query: 563  QNLKEEGGLDLPSGRKPVAAATIVPRQAKEDLTLPQDSAMTPPLPLQDTDLSSAPKPVAA 622
            ++       + P    P A+    P +       P++S ++PP    +    S P     
Sbjct: 578  ESPMSPPPEESPMSPPPEASRLFPPFEESPLSPPPEESPLSPP---PEASRLSPP----- 629

Query: 623  ATIVSQQAEEGLTLPQDSVMTPPLPLQDTELSSAPKPVAAATLVSQQAEEGLTLPQDSAM 682
                          P+DS M+P  P +++ +S  P+       VS+ +     LP  S +
Sbjct: 630  --------------PEDSPMSP--PPEESPMSPPPE-------VSRLS----PLPVVSRL 662

Query: 683  TPPLPLQDTDLSSAPKPVAAATLVSQQAEEGLTLPQDSAMTPPLPLQDTDLSSAPKPVAA 742
            +P  P +++ LS  P P  + T    +A      P+DS  +PP      D  ++P P  +
Sbjct: 663  SP--PPEESPLS--PPPEESPTSPPPEASRLSPPPEDSPTSPP----PEDSPASPPPEDS 714

Query: 743  ATLVSQQAEEGLTLPQDSAMTPPLPLQDTDLSSAPK-----PVAAATIVSQQAEEGLTLP 797
               +  +    L LP++  + P    +   LS  P+     P      +S QAEE    P
Sbjct: 715  LMSLPLEESPLLPLPEEPQLCP--RSEGPHLSPRPEEPHLSPRPEEPHLSPQAEEPHLSP 772

Query: 798  QDSAMTPPLPLQDTDLSSAPKPVAAATIVSQQAEEGLTLPQDSAMTPPLPLQDTDLSSAP 857
            Q          ++  LS    P A    +S Q EE    PQ          ++  LS   
Sbjct: 773  QPEEPCLCAVPEEPHLS----PQAEGPHLSPQPEELHLSPQ---------TEEPHLS--- 816

Query: 858  KPVAAATPVSQQAEEGLTLPQ-DSAMTPPLPLQDTDLSSAPKPVAAATPVSQQAEEGLTL 916
             PV     +S Q EE    PQ +     P P +++ LS    P     P+S + E+    
Sbjct: 817  -PVPEEPCLSPQPEESHLSPQSEEPCLSPRP-EESHLS----PELEKPPLSPRPEKPPEE 870

Query: 917  PQDSAMTAPLPLQDTGPTSGPEPLAVATPQTLQAEAGCAPGTEPVATMAQQEVGEALGPR 976
            P        LPL        P P   +    L   A   PG  P++              
Sbjct: 871  PGQCPAPEELPL-------FPPPGEPSLSPLLGEPALSEPGEPPLS-------------- 909

Query: 977  PAPEEKNAALPTVP--EPAALDQVQQDDPQPAAEAGTPWAAQEDADSTLG-----MEALS 1029
            P PEE    LP  P  EP+   Q+   DP P   +    AA   A S LG       A  
Sbjct: 910  PLPEE----LPLSPSGEPSLSPQLMPPDPLPPPLSPIITAAAPPALSPLGELEYPFGAKG 965

Query: 1030 LPEPASGAGEEIAEALSRPGREACLEARAHTGDGAKPDSPQKETLEVENQQEGGLKPLAQ 1089
              +P S     I E    P  EA             P SP            G   P+  
Sbjct: 966  DSDPESPLAAPILETPISPPPEANCTDPEPVPPMILPPSP--------GSPVGPASPILM 1017

Query: 1090 EHGPR--SALGGAREVP-DAPPAACP----EVSQARLLSPAREERGLSGKSTPEPTLPSA 1142
            E  P   S L     VP ++PP+ C      +S    LSP  +  G+S     E  L   
Sbjct: 1018 EPLPPQCSPLLQHSLVPQNSPPSQCSPPALPLSVPSPLSPIGKVVGVS----DEAELHEM 1073

Query: 1143 VATEASLDSCPESSVGAVSSL-----DRGCP-DAPAPTSAPTSQQPEPVLGLGSVEQPHE 1196
               + S   CP     A S L     D  CP  +PAP     S   E    L  ++ P  
Sbjct: 1074 ETEKVSEPECPALEPSATSPLPSPMGDLSCPAPSPAPALDDFSGLGEDTAPLDGIDAPGS 1133

Query: 1197 VPSVLGTPLLQPPENLAKGQPSTPVDRPLGPDPSAPGTLAGAALPPLEPPAPCLCQDPQE 1256
             P        Q P +LA     +PV   L P+  AP T       P+E    C     Q 
Sbjct: 1134 QPEP-----GQTPGSLASELKGSPV--LLDPEELAPVT-------PMEVYPECKQTAGQG 1179

Query: 1257 DSVEDEEPPGSLGLPPPQAGVQPAAAAVSGTTQPLGTGPRVSLSPHS-PLL-SPKVASMD 1314
               E++E P +   P P   ++   + +      L  G   +  P S PLL SP      
Sbjct: 1180 SPCEEQEEPRAPVAPTPPTLIK---SDIVNEISNLSQGDASASFPGSEPLLGSPDPEGGG 1236

Query: 1315 AKDLALQILPPCQVPPPSGPQSPAGPQG---LSAPEQQEDEDSLEEDSPRALGSGQHSDS 1371
            +  + L +         S   SPA  +G   L      E +DSL  D+  A+  G+    
Sbjct: 1237 SLSMELGV---------STDVSPARDEGSLRLCTDSLPETDDSLLCDAGTAISGGKAEGE 1287

Query: 1372 HGESSAELDEQDILAPQTVQCPA-QAPAGGS 1401
             G   +      I   ++   P  + P GG+
Sbjct: 1288 KGRRRSSPARSRIKQGRSSSFPGRRRPRGGA 1318



 Score = 49.3 bits (116), Expect = 3e-05
 Identities = 154/683 (22%), Positives = 230/683 (33%), Gaps = 101/683 (14%)

Query: 647  PLQDTELSSAPKPVAAATLVSQQAEEGLTLPQDSAMTPPLPLQDTDLSSAPKPVAAATLV 706
            P   T  +  PKP     L+   + +GL + Q S    P P Q       P  VA    V
Sbjct: 3761 PGVQTNQALGPKPQG---LMPPSSHQGLLVQQLS----PQPPQGPQGMLGPAQVA----V 3809

Query: 707  SQQAEEGLTLPQDS----AMTPPLPLQDTDLSSAPKPVAAATLVS-QQAEEGLTLPQDSA 761
             QQ   G   PQ       MT    L    L+   + +    LV+ QQ ++     Q  +
Sbjct: 3810 LQQQHPGALGPQGPHRQVLMTQSRVLSSPQLAQQGQGLMGHRLVTAQQQQQQQQHQQQGS 3869

Query: 762  MTPPLPLQDTDLSSAPKPVAAATIVS--QQAEEGLTLPQDSAMTPPLPLQDTDLSSAPKP 819
            M     LQ + +S + +P  +A  +   QQ ++   L Q       L  Q        + 
Sbjct: 3870 MAGLSHLQQSLMSHSGQPKLSAQPMGSLQQLQQQQQLQQQQQ----LQQQQQQQLQQQQQ 3925

Query: 820  VAAATIVSQQAEEGLTLPQDSAMTPPLPLQDTDLSSAPKPVAAATPVSQQAEEGLTLPQD 879
            +    +  QQ ++ L   Q       L  Q   L    +         QQ ++   L Q 
Sbjct: 3926 LQQQQLQQQQQQQQLQQQQQQQ----LQQQQQQLQQQQQQQQQQFQQQQQQQQMGLLNQS 3981

Query: 880  SAMTPPLPLQDTDLSSAPKPVAAATPVSQQAEEGLTLPQ----DSAMTAPLPLQDTGPTS 935
              +  P   Q   ++  P     A P+   +  G   P             P   +  T 
Sbjct: 3982 RTLLSPQQQQQQQVALGPG--MPAKPLQHFSSPGALGPTLLLTGKEQNTVDPAVSSEATE 4039

Query: 936  GPE-----PLAVAT-PQTLQAEAGCAPGTEPVATMAQQEVGEALGPRPAPEEKNAALPTV 989
            GP      PLA+ T P+++  E G     E   +++       + P+P P+  +  L   
Sbjct: 4040 GPSTHQGGPLAIGTTPESMATEPG-----EVKPSLSGDSQLLLVQPQPQPQPSSLQLQP- 4093

Query: 990  PEPAALDQVQQDDPQPAAEAGTPWAAQEDADSTLGMEALSLP----EPASGAGEE---IA 1042
              P  L   QQ        AG     Q  + S+   EA S+P    +P+   G++   + 
Sbjct: 4094 --PLRLPGQQQQQVSLLHTAGGGSHGQLGSGSS--SEASSVPHLLAQPSVSLGDQPGSMT 4149

Query: 1043 EALSRPGREACLEARAHTGDGAKPDSPQKETLEVENQQEGGLKPLAQEHGPRSALGGARE 1102
            + L  P ++  LE       G +P  P       +     G+ P   +   R+ L G   
Sbjct: 4150 QNLLGP-QQPMLERPMQNNTGPQPPKPGPVLQSGQGLPGVGIMPTVGQL--RAQLQGVLA 4206

Query: 1103 VPDAPPAACPEVSQA--RLLSPAREERGLSGKSTP---EP-----TLPSAVATEASLDSC 1152
                     P+  Q    LL   + ++  + + TP   EP      L   +  +  L   
Sbjct: 4207 KNPQLRHLSPQQQQQLQALLMQRQLQQSQAVRQTPPYQEPGTQTSPLQGLLGCQPQLGGF 4266

Query: 1153 PESSVGAVSSLDRGCPDAPAPTSAPTSQQPEPVLGLGSVEQPHEVPSVLGTPLLQPPENL 1212
            P    G +  L  G    P P   P    P   L  G V  P     V  TP    P+  
Sbjct: 4267 PGPQTGPLQELGAG----PRPQGPPRLPAPPGALSTGPVLGP-----VHPTPPPSSPQ-- 4315

Query: 1213 AKGQPSTPVDRPLGPDPSAPGTLAGAALPPLEPPAPCLCQDPQEDSVEDEEPPGSLGLPP 1272
               +P  P   P  P    P     A LPP  P  P     PQ  ++E           P
Sbjct: 4316 ---EPKRPSQLP-SPSSQLP---TEAQLPPTHPGTP----KPQGPTLE-----------P 4353

Query: 1273 PQAGVQPAAAAVSGTTQPLGTGP 1295
            P   V PAAA ++ T    G GP
Sbjct: 4354 PPGRVSPAAAQLADTLFSKGLGP 4376



 Score = 45.1 bits (105), Expect = 5e-04
 Identities = 78/294 (26%), Positives = 107/294 (36%), Gaps = 46/294 (15%)

Query: 45   LTPGPSHLALTFLPSKPGARPQPEGASWDAGPGGAPSAWADPGEGGPSPMLLPEGLS--- 101
            L+P P    L  +P +P   PQ EG          P     P E   SP      LS   
Sbjct: 770  LSPQPEEPCLCAVPEEPHLSPQAEG----------PHLSPQPEELHLSPQTEEPHLSPVP 819

Query: 102  SQALSTEAPLPATLEPRIVMGEETCQALLSPRAARTALRDQ-EGGHASPDP--PPELCSQ 158
             +   +  P  + L P+    EE C   LSPR   + L  + E    SP P  PPE   Q
Sbjct: 820  EEPCLSPQPEESHLSPQ---SEEPC---LSPRPEESHLSPELEKPPLSPRPEKPPEEPGQ 873

Query: 159  GDLSVPSPPPDPDSFFTPPSTPTKTTYALLPACGPHGDARDSEAELRDELLDSPPASPSG 218
                   P P+    F PP  P+ +     PA    G+   S   L +EL  SP   PS 
Sbjct: 874  ------CPAPEELPLFPPPGEPSLSPLLGEPALSEPGEPPLS--PLPEELPLSPSGEPSL 925

Query: 219  SYITADGDSWASSPSCSLSLLAPAEGLDFPSGWGLSPQGSMVDERELHPAGTPEPPSSES 278
            S      D      S  ++  AP           LSP G +  E      G  +P S  +
Sbjct: 926  SPQLMPPDPLPPPLSPIITAAAPP---------ALSPLGEL--EYPFGAKGDSDPESPLA 974

Query: 279  SLSADSSSSWGQEGHFFDLDFLANDPMIPAALLPFQGSLIFQVEAVEVTPLSPE 332
            +   ++  S   E +  D      +P+ P  L P  GS +     + + PL P+
Sbjct: 975  APILETPISPPPEANCTD-----PEPVPPMILPPSPGSPVGPASPILMEPLPPQ 1023



 Score = 43.9 bits (102), Expect = 0.001
 Identities = 134/609 (22%), Positives = 197/609 (32%), Gaps = 68/609 (11%)

Query: 606  LPLQDTDLSSAPKPVAAATIV--SQQAEEGLTLPQDSVMTPPLPLQDTELSSAPKPVAAA 663
            +P Q   L S P P AA TI   S     GL+   D  + PP         S P P +  
Sbjct: 2106 IPPQPGALGSPP-PAAAPTIFIGSPTTPAGLSTSADGFLKPPA-------GSVPGPDSPG 2157

Query: 664  TLVSQQAEEGLTLPQDSAMTPPLPLQDTDLSSAPKPVAAATLVSQQAEEGLTLPQDSAMT 723
             L        L LP    +   +P QD    +   P+      +         P  +   
Sbjct: 2158 ELF-------LKLPPQ--VPAQVPSQDPFGLAPAYPLEPRFPTAPPTYPPYPSPTGAPAQ 2208

Query: 724  PPLPLQDTDLSSAPKPVAAATLVSQQAEEGLTLPQDSAMTPPLPLQDTDLSSAPKPVAAA 783
            PP+      L ++ +P A           G    Q S   P L  +   L +   P +  
Sbjct: 2209 PPM------LGASSRPGAGQPGEFHTTPPGTPRHQPSTPDPFLKPRCPSLDNLAVPESPG 2262

Query: 784  TIVSQQAEEGLTLPQDSAMTPPLPLQDTDLSSAPKPVAAATIVSQQAEEGLTLPQDSAMT 843
                + +E  L+ P        L ++  +L ++        +    +      P      
Sbjct: 2263 VGGGKASEPLLSPPPFGESRKALEVKKEELGASSPSYGPPNLGFVDS------PSSGTHL 2316

Query: 844  PPLPLQDTDLSSAPKPVAAATPVSQQAEEGLTL--PQDSAMTPPLPLQDTDL-------S 894
              L L+  D+  AP    A+    Q    GL    P  +    P P    D+        
Sbjct: 2317 GGLELKTPDVFKAPLTPRASQVEPQSPGLGLRPQEPPPAQALAPSPPSHPDIFRPGSYTD 2376

Query: 895  SAPKPVAAATPVSQQAEEGLTLPQDSAMTAPLPLQDTGPTSGPEPLAVATPQTLQAEAGC 954
               +P     P     E    LP  S  + P       P S     +  TP+ L AEA C
Sbjct: 2377 PYAQPPLTPRPQPPPPESCCALPPRSLPSDPFSRVPASPQSQSSSQSPLTPRPLSAEAFC 2436

Query: 955  APGTEPVATMAQQEVGEALGP-RPAPEEKNAALPTVPEPAALDQVQQDDPQPAAEAGTPW 1013
                 PV    Q     +  P RP   +  A L   P P          P+ A +AG+  
Sbjct: 2437 ---PSPVTPRFQSPDPYSRPPSRPQSRDPFAPLHKPPRP--------QPPEVAFKAGSL- 2484

Query: 1014 AAQEDADSTLGMEALSLPEPASGAGEEIAEALSRPGREACLEARAHTGDGAKPDSPQKET 1073
                 A ++LG        PA  AGE  A+  S  G+         TG      SP + T
Sbjct: 2485 -----AHTSLGAGGFPAALPAGPAGELHAKVPS--GQPPNFVRSPGTGAFVGTPSPMRFT 2537

Query: 1074 LEVENQQEGGLKPLAQEHGPRSALGGAREVPDAPPAACPEVSQARLLS----PAREERGL 1129
               +   E  LKP   + G     G        P    P+ +   + +    P+    G 
Sbjct: 2538 FP-QAVGEPSLKPPVPQPGLPPPHGINSHFGPGPTLGKPQSTNYTVATGNFHPSGSPLGP 2596

Query: 1130 SGKSTPEPTLPSAVATEASLDSCPESSVGAVSSLDRGCPDAPAPTSAPTSQQPEPVLGLG 1189
            S  ST E    S +   + L   P +  G++  L  G       TS P  ++ +P  G+G
Sbjct: 2597 SSGSTGESYGLSPLRPPSVLP--PPAPDGSLPYLSHGASQRSGITS-PVEKREDPGTGMG 2653

Query: 1190 SVEQPHEVP 1198
            S     E+P
Sbjct: 2654 SSLATAELP 2662



 Score = 43.1 bits (100), Expect = 0.002
 Identities = 137/635 (21%), Positives = 199/635 (31%), Gaps = 78/635 (12%)

Query: 727  PLQDTDLSSAPKPVAAATLVSQQAEEGLTLPQDSAMTPPLPLQDTDLSSAPKPVAAATIV 786
            P   T+ +  PKP     L+   + +GL + Q S    P P Q       P  VA    V
Sbjct: 3761 PGVQTNQALGPKPQG---LMPPSSHQGLLVQQLS----PQPPQGPQGMLGPAQVA----V 3809

Query: 787  SQQAEEGLTLPQDS----AMTPPLPLQDTDLSSAPKPVAAATIVS-QQAEEGLTLPQDSA 841
             QQ   G   PQ       MT    L    L+   + +    +V+ QQ ++     Q  +
Sbjct: 3810 LQQQHPGALGPQGPHRQVLMTQSRVLSSPQLAQQGQGLMGHRLVTAQQQQQQQQHQQQGS 3869

Query: 842  MTPPLPLQDTDLSSAPKPVAAATPVSQQAEEGLTLPQDSAMTPPLPLQDTDLSSAPKPVA 901
            M     LQ + +S + +P  +A P+    +    L Q   +     LQ        +   
Sbjct: 3870 MAGLSHLQQSLMSHSGQPKLSAQPMGSLQQ----LQQQQQLQQQQQLQQQQQQQLQQQQQ 3925

Query: 902  AATPVSQQAEEGLTLPQDSAMTAPLPLQDTGPTSGPEPLAVATPQTLQAEAGCAPGTEPV 961
                  QQ ++   L Q          Q        +       Q  Q           +
Sbjct: 3926 LQQQQLQQQQQQQQLQQQQQQQLQQQQQQLQQQQQQQQQQFQQQQQQQQMGLLNQSRTLL 3985

Query: 962  ATMAQQEVGEALGP-RPAPEEKNAALPTVPEPAALDQVQQDDPQPAAEAGTPWAAQEDAD 1020
            +   QQ+   ALGP  PA   ++ + P    P  L   ++               Q   D
Sbjct: 3986 SPQQQQQQQVALGPGMPAKPLQHFSSPGALGPTLLLTGKE---------------QNTVD 4030

Query: 1021 STLGMEALSLPEPASGAGEEIAEALSRPGREACLEARAHTGDGAKPDSPQKETLEVENQQ 1080
              +  EA   P    G    I                     G  P+S   E  EV+   
Sbjct: 4031 PAVSSEATEGPSTHQGGPLAI---------------------GTTPESMATEPGEVKPSL 4069

Query: 1081 EGGLKPLAQEHGPRSALGGAREVPDA--PPAACPEVSQARLLSPAREERGLSGKSTPEPT 1138
             G  + L  +  P+      +  P    P     +VS           +  SG S+   +
Sbjct: 4070 SGDSQLLLVQPQPQPQPSSLQLQPPLRLPGQQQQQVSLLHTAGGGSHGQLGSGSSSEASS 4129

Query: 1139 LPSAVATEA-SLDSCPESSVGAVSSLDRGCPDAPAPTSA-PTSQQPEPVLGLGSVEQPHE 1196
            +P  +A  + SL   P S    +    +   + P   +  P   +P PVL  G       
Sbjct: 4130 VPHLLAQPSVSLGDQPGSMTQNLLGPQQPMLERPMQNNTGPQPPKPGPVLQSGQGLPGVG 4189

Query: 1197 VPSVLGTPLLQPPENLAKGQPSTPVDRPLGPDPSAPGTLAGAALPPLEPPAPCLCQDP-- 1254
            +   +G    Q    LAK     P  R L P       L    +      +  + Q P  
Sbjct: 4190 IMPTVGQLRAQLQGVLAKN----PQLRHLSPQQQQQ--LQALLMQRQLQQSQAVRQTPPY 4243

Query: 1255 QEDSVEDEEPPGSLGLPPPQAGVQPAAAAVSGTTQPLGTGPRVSLSPHSPLLSPKVASMD 1314
            QE   +     G LG  P   G        +G  Q LG GPR    P  P      A   
Sbjct: 4244 QEPGTQTSPLQGLLGCQPQLGGFP---GPQTGPLQELGAGPRPQGPPRLP------APPG 4294

Query: 1315 AKDLALQILPPCQVPPPSGPQSPAGPQGLSAPEQQ 1349
            A      + P    PPPS PQ P  P  L +P  Q
Sbjct: 4295 ALSTGPVLGPVHPTPPPSSPQEPKRPSQLPSPSSQ 4329



 Score = 42.4 bits (98), Expect = 0.004
 Identities = 193/878 (21%), Positives = 303/878 (34%), Gaps = 152/878 (17%)

Query: 605  PLPLQDTDLSSAPKPVAAATIVSQQAEEGLTLPQDSVMTPPLPLQDTELSSAPKPVAAAT 664
            P P  D   +S P+  +    V  + EEG   P         P Q T  +   +P  AA 
Sbjct: 3100 PPPAAD---ASEPRLASVLPEVKPKVEEGGRHPS--------PCQFTIATPKVEPAPAAN 3148

Query: 665  LVSQQAEEGLTLPQDSAMTPPLPLQDTDLSSAPKPVAAATLVSQQAEEGLTLPQDSAMTP 724
             +      GL L    +M   +  +DT + + P   +  T  +++A  G T    + +  
Sbjct: 3149 SL------GLGLKPGQSM---MGSRDTRMGTGPFSSSGHT--AEKASFGATGGPPAHLLT 3197

Query: 725  PLPLQDTDLSSAPKPVAAATLVSQQAEEG-LTLPQDSAMT-PPLPLQDTDLSSAPKPVAA 782
            P PL          P  ++ L   + E G LTLP   A +   L   ++ L ++  P+  
Sbjct: 3198 PSPLSG--------PGGSSLLEKFELESGALTLPGGPAASGDELDKMESSLVASELPLLI 3249

Query: 783  ATIVSQQAEEGLTLPQDSAMTPPLPLQDTD-----LSSAPKPVAAATIVSQQA------- 830
              ++  + +E     Q SA   P   Q        L SAP P  A ++  + +       
Sbjct: 3250 EDLLEHEKKELQKKQQLSAQLQPAQQQQQQQQQHSLLSAPGPAQAMSLPHEGSSPSLAGS 3309

Query: 831  EEGLTLPQDSAMTP--PLPLQDTDLSSAPKPVAAATPVSQQAEEGLTLP-QDSAMTPPLP 887
            ++ L+L    A  P  P PL  T   +       A  ++  + +G  L  Q       +P
Sbjct: 3310 QQQLSLGLAGARQPGLPQPLMPTQPPAHALQQRLAPSMAMVSNQGHMLSGQHGGQAGLVP 3369

Query: 888  LQDTDLSSAPKPVAAATPVSQQAEEGLTLPQDSAMTAPLPLQDTGPTSGPE---PLAVAT 944
             Q +    + KP+    P      + L + Q  A +   P  D    +  +   P+A A 
Sbjct: 3370 QQSSQPVLSQKPMGTMPPSMCMKPQQLAMQQQLANSF-FPDTDLDKFAAEDIIDPIAKAK 3428

Query: 945  PQTL--------QAEAGCAPGT--EPVATMAQQEVGEALGPRP---------APEEKNAA 985
               L        Q   G APG   + V+ +AQ+  G   GP           + +E++A 
Sbjct: 3429 MVALKGIKKVMAQGSIGVAPGMNRQQVSLLAQRLSG---GPSSDLQNHVAAGSGQERSAG 3485

Query: 986  LPTVPEPAALDQVQQDDPQPAAEAGTPWAAQEDADSTLGMEALSLPEPASGAGEEIAEAL 1045
             P+ P P         +P   A+     A Q   +  L      L        E+I   +
Sbjct: 3486 DPSQPRP---------NPPTFAQGVINEADQRQYEEWLFHTQQLLQMQLKVLEEQIG--V 3534

Query: 1046 SRPGREA-CLEARAHTGDGAKPDSPQKETLEVENQQEGGL-KPLAQ------EHGPRSA- 1096
             R  R+A C + R     G +      E L++  +Q+  + K L Q      EH    A 
Sbjct: 3535 HRKSRKALCAKQRTAKKAGREFPEADAEKLKLVTEQQSKIQKQLDQVRKQQKEHTNLMAE 3594

Query: 1097 -LGGAREVPDAPPAACPEVSQARLLSPAREERGLSGKSTPEPTLPSAVATEASLDSCPES 1155
                 ++          + S    LSP++  R L+        LP  +     L   P+ 
Sbjct: 3595 YRNKQQQQQQQQQQQQQQHSAVLALSPSQSPRLLT-------KLPGQLLPGHGLQP-PQG 3646

Query: 1156 SVGAVSSLDRGCPDAPAPTSAPTSQQPEPVLGLGSVEQPHEVPSVLGTPLLQPPENLAKG 1215
              G  +   R  P   A    P      P L     +Q  +  S     L  P      G
Sbjct: 3647 PPGGQAGGLRLTPGGMALPGQPGG----PFLNTALAQQQQQQHSGGAGSLAGPSGGFFPG 3702

Query: 1216 QPSTPVDRPLGPDPSAPGTLAGAALPPLEPPAPCLCQDPQEDSVEDEEPPGSLGLPPPQA 1275
              +    R LGPD      L       L+     L Q  Q+   + ++    LG    Q 
Sbjct: 3703 NLAL---RSLGPD----SRLLQERQLQLQQQRMQLAQKLQQQQQQQQQQQHLLG----QV 3751

Query: 1276 GVQPAAAAVSG--TTQPLGTGPRVSLSPHSPLLSPKVASMDAKDLALQILPPCQVPPPSG 1333
             +Q       G  T Q LG  P+  + P S            + L +Q L P    PP G
Sbjct: 3752 AIQQQQQQGPGVQTNQALGPKPQGLMPPSSH-----------QGLLVQQLSP---QPPQG 3797

Query: 1334 PQSPAGPQGLSAPEQQEDEDSLEEDSPRALG-SGQHSDSHGESSAELDEQDILAPQTVQC 1392
            PQ   GP  ++  +QQ          P ALG  G H       S  L    +        
Sbjct: 3798 PQGMLGPAQVAVLQQQH---------PGALGPQGPHRQVLMTQSRVLSSPQL-------- 3840

Query: 1393 PAQAPAGGSEETIAKAKQSRSEKKARKAMSKLGLRQIQ 1430
             AQ   G     +  A+Q + +++ ++  S  GL  +Q
Sbjct: 3841 -AQQGQGLMGHRLVTAQQQQQQQQHQQQGSMAGLSHLQ 3877



 Score = 40.8 bits (94), Expect = 0.010
 Identities = 87/375 (23%), Positives = 133/375 (35%), Gaps = 54/375 (14%)

Query: 931  TGPTSGPEPLAVATPQTLQAEA--GCAP----GTEPVATMAQQEVGEALGPRPAPEEKN- 983
            + P + P  L    P ++Q +   G  P    G  P    + ++   AL  R   E K+ 
Sbjct: 4617 SNPPTPPSSLPPTPPPSVQQKMVNGVTPSEELGEHPKDAASARDSERAL--RDTSEVKSL 4674

Query: 984  ---AALPTVPEPAALD-QVQQDDPQPAAEAGTPWAAQEDADSTLGMEALSLPEPASGAGE 1039
               AALPT P     D +++ D+   + ++  P ++ E   S LG EA   P   SG  E
Sbjct: 4675 DLLAALPTPPHNQTEDVRMESDEDSDSPDSIVPASSPE---SILGEEAPRFPHLGSGRWE 4731

Query: 1040 EIAEALS-----------------RPGREACLEARA-------HTGDGAKPDSPQKETLE 1075
            +   ALS                 +P     LE            G G++       +  
Sbjct: 4732 QEDRALSPVIPLIPRASIPVFPDTKPYGALGLEVPGKLPVTTWEKGKGSEVSVMLTVSAA 4791

Query: 1076 VENQQEGGLKPLAQEHGPRSALGGAREVPDAPPAACPEVSQARLLSPAREERGLSGKSTP 1135
                  G +  +A+    +         P++P  A  E  +     P  +E+GL GKS P
Sbjct: 4792 AAKNLNGVMVAVAELLSMKIPNSYEVLFPESPARAGTEPKKGEAEGPGGKEKGLEGKS-P 4850

Query: 1136 EPTLPSAVATEASLDSCP-ESSVGAVSSLDRGCPDAPAPT----SAPTSQQPEPVLGLGS 1190
            +         +A L     +S +  +S L +  P    PT    +   S      L    
Sbjct: 4851 DTGPDWLKQFDAVLPGYTLKSQLDILSLLKQESPAPEPPTQHSYTYNVSNLDVRQLSAPP 4910

Query: 1191 VEQPHEVPSVLGTPLLQPPENLAKGQPSTPVDRPLGPDPSAPGTLAGAALPPLEPPAPCL 1250
             E+P   PS L      PP       P+ P+      +P  P  L  A+ P    P P  
Sbjct: 4911 PEEPSPPPSPLAPSPASPPTEPLVELPTEPL-----AEPPVPSPLPLASSPESARPKP-R 4964

Query: 1251 CQDPQEDSVEDEEPP 1265
             + P+E   ED  PP
Sbjct: 4965 ARPPEEG--EDSRPP 4977



 Score = 39.7 bits (91), Expect = 0.023
 Identities = 202/1000 (20%), Positives = 307/1000 (30%), Gaps = 167/1000 (16%)

Query: 501  RVTPQAGEEETDSTAGQESAAMAMPQPSQEGISEILGQESVTAEKLPTPQE--ETSLTLC 558
            R+ PQ G   +   A   +  +  P       +   G     A  +P P    E  L L 
Sbjct: 2105 RIPPQPGALGSPPPAAAPTIFIGSPTTPAGLSTSADGFLKPPAGSVPGPDSPGELFLKLP 2164

Query: 559  PDSPQNLKEEGGLDLPSGRKPVAAATIVPRQAKEDLTLPQDSAMTPPLPLQDTDLSSAPK 618
            P  P  +  +     P G  P  A  + PR      T P   + T   P Q   L ++ +
Sbjct: 2165 PQVPAQVPSQD----PFGLAP--AYPLEPRFPTAPPTYPPYPSPTGA-PAQPPMLGASSR 2217

Query: 619  PVAAATIVSQQAEEGLTLPQDSVMTPPLPLQDTELSSAPKPVAAATLVSQQAEEGLTLPQ 678
            P A           G    Q S   P L  +   L +   P +      + +E  L+ P 
Sbjct: 2218 PGAGQPGEFHTTPPGTPRHQPSTPDPFLKPRCPSLDNLAVPESPGVGGGKASEPLLSPPP 2277

Query: 679  DSAMTPPLPLQDTDLSSAPKPVAAATLVSQQAEEGLTLPQDSAMTPPLPLQDTDLSSAPK 738
                   L ++  +L ++        L    +      P        L L+  D+  AP 
Sbjct: 2278 FGESRKALEVKKEELGASSPSYGPPNLGFVDS------PSSGTHLGGLELKTPDVFKAPL 2331

Query: 739  PVAAATLVSQQAEEGLTLPQDSAMTPPLPLQDTDLSSAPKPVAAATIVSQQAEEGLTL-- 796
               A+ +  Q    GL  PQ+    PP         S P      +     A+  LT   
Sbjct: 2332 TPRASQVEPQSPGLGLR-PQEP---PPAQALAPSPPSHPDIFRPGSYTDPYAQPPLTPRP 2387

Query: 797  ----PQDSAMTPPLPLQDTDLSSAPKPVAAATIVSQQAEEGLTLPQDSAMTPPLPLQDTD 852
                P+     PP  L     S  P     A+  SQ + +    P+  +     P   T 
Sbjct: 2388 QPPPPESCCALPPRSLPSDPFSRVP-----ASPQSQSSSQSPLTPRPLSAEAFCPSPVTP 2442

Query: 853  LSSAPKPVAAATPVSQQAEEGLTLPQDSAMTPPL------PLQDTDLSSAPKPVAAATPV 906
               +P P +      Q  +    L +     PP        L  T L +   P  AA P 
Sbjct: 2443 RFQSPDPYSRPPSRPQSRDPFAPLHKPPRPQPPEVAFKAGSLAHTSLGAGGFP--AALPA 2500

Query: 907  SQQAEEGLTLPQDSA------------MTAPLPLQDTGPTSGPEPL--------AVATPQ 946
                E    +P                +  P P++ T P +  EP          +  P 
Sbjct: 2501 GPAGELHAKVPSGQPPNFVRSPGTGAFVGTPSPMRFTFPQAVGEPSLKPPVPQPGLPPPH 2560

Query: 947  TLQAEAGCAPG-------TEPVATMAQQEVGEALGPRPAPEEKNAALPTVPEPAALDQVQ 999
             + +  G  P           VAT      G  LGP      ++  L  +  P+ L    
Sbjct: 2561 GINSHFGPGPTLGKPQSTNYTVATGNFHPSGSPLGPSSGSTGESYGLSPLRPPSVL---- 2616

Query: 1000 QDDPQPAAEAGTPWAAQEDAD-STLGMEALSLPEPASGAGEEIAEALSRPGREACLEARA 1058
               P PA +   P+ +   +  S +        +P +G G  +A A     ++  +   +
Sbjct: 2617 ---PPPAPDGSLPYLSHGASQRSGITSPVEKREDPGTGMGSSLATAELPGTQDPGMSGLS 2673

Query: 1059 HTGDGAKPDSPQKETLEVENQQEGGLKPLAQEHGPRSALGGAREVPDA------------ 1106
             T    +    ++   E+  +Q+     L QE    +A  GA   P +            
Sbjct: 2674 QTE--LEKQRQRQRLRELLIRQQIQRNTLRQEKETAAAAAGAVGPPGSWGAEPSSPAFEQ 2731

Query: 1107 ------PPAACPEVSQARLLSPAREERGLSGK----STPEPTLPSAVATEASLDSCPESS 1156
                  P A   + S    L P++    + G     S    + P   AT +S+D      
Sbjct: 2732 LSRGQTPFAGTQDKSSLVGLPPSKLSGPILGPGSFPSDDRLSRPPPPATPSSMDVNSRQL 2791

Query: 1157 VGAVSSLDRGCPDAPAPTSAPTSQQPEPV-----------------LGLGSVEQPHEVPS 1199
            VG   +  +    AP P S P  QQ + +                     S   P     
Sbjct: 2792 VGGSQAFYQR---APYPGSLPLQQQQQQLWQQQQATAATSMRFAMSARFPSTPGPELGRQ 2848

Query: 1200 VLGTPLLQPPENLAKGQPSTPVDRPLGPDP------------SAPGTLAGAALPPLEPPA 1247
             LG+PL      L    P  PV  P GP                 GT      PP  P  
Sbjct: 2849 ALGSPLAGISTRLPG--PGEPVPGPAGPAQFIELRHNVQKGLGPGGTPFPGQGPPQRPRF 2906

Query: 1248 PCLCQDPQEDSVEDEEPPGSLGLPPPQAGVQPA---------AAAVSGTTQPLGTGPRVS 1298
              + +DP   + E        GLPP +    PA              G T P G    V+
Sbjct: 2907 YPVSEDPHRLAPEGLRGLAVSGLPPQKPSAPPAPELNNSLHPTPHTKGPTLPTGL-ELVN 2965

Query: 1299 LSPHSPLLS-PKVASMDAKDLALQILPPCQVPPPSGPQSPAGPQGLSAPEQQEDEDSLE- 1356
              P S  L  P   +++A  L      PC        + P       A +  ED++ L  
Sbjct: 2966 RPPSSTELGRPNPLALEAGKL------PC--------EDPELDDDFDAHKALEDDEELAH 3011

Query: 1357 ----------EDSPRALGSGQHSDSHGESSAELDEQDILA 1386
                      +D    L + + +D H +     DE D+LA
Sbjct: 3012 LGLGVDVAKGDDELGTLENLETNDPHLDDLLNGDEFDLLA 3051



 Score = 35.0 bits (79), Expect = 0.57
 Identities = 36/128 (28%), Positives = 51/128 (39%), Gaps = 18/128 (14%)

Query: 132  PRAARTALRDQEGGHASPDPPP---ELCSQGDLSVPSPPPDPDSFFTPPSTPTKTTYALL 188
            P   ++ LR   G  A P  P    +L ++ +LS P  PP       PPS   K    + 
Sbjct: 4584 PVNGQSQLRGAFGSGALPTGPDYYSQLLTKNNLSNPPTPPSSLPPTPPPSVQQKMVNGVT 4643

Query: 189  PA--CGPH----GDARDSEAELRD-------ELLDSPPASPSGSY--ITADGDSWASSPS 233
            P+   G H      ARDSE  LRD       +LL + P  P      +  + D  + SP 
Sbjct: 4644 PSEELGEHPKDAASARDSERALRDTSEVKSLDLLAALPTPPHNQTEDVRMESDEDSDSPD 4703

Query: 234  CSLSLLAP 241
              +   +P
Sbjct: 4704 SIVPASSP 4711



 Score = 34.7 bits (78), Expect = 0.74
 Identities = 46/174 (26%), Positives = 63/174 (36%), Gaps = 16/174 (9%)

Query: 112  PATLEPRIVMGEETCQALLSPRAARTALRDQEGGHASPDPPPELCSQGDLSVPSPPPDPD 171
            P    P I +G  T  A LS  +A   L+   G    PD P EL  +    VP+  P  D
Sbjct: 2117 PPAAAPTIFIGSPTTPAGLST-SADGFLKPPAGSVPGPDSPGELFLKLPPQVPAQVPSQD 2175

Query: 172  SFFTPPSTPTKTTYALLPACGPHGDARDSEAELRDELLDS---PPASPSGSYITADGDSW 228
             F   P+ P +  +   P   P   +  + A  +  +L +   P A   G + T    + 
Sbjct: 2176 PFGLAPAYPLEPRFPTAPPTYPPYPS-PTGAPAQPPMLGASSRPGAGQPGEFHTTPPGTP 2234

Query: 229  ASSPSCSLSLLAP----AEGLDFPSGWGLSPQGSMVDERELHPAGTPEPPSSES 278
               PS     L P     + L  P   G+   G    E  L P     PP  ES
Sbjct: 2235 RHQPSTPDPFLKPRCPSLDNLAVPESPGVG--GGKASEPLLSP-----PPFGES 2281



 Score = 32.3 bits (72), Expect = 3.7
 Identities = 69/269 (25%), Positives = 96/269 (35%), Gaps = 57/269 (21%)

Query: 44   ALTPGPSHLALTFLP-------SKPGARPQPEGASWDAGPGGAPSAWADPGEGGPSPML- 95
            AL P P      F P       ++P   P+P+       P    S  A P    PS    
Sbjct: 2357 ALAPSPPSHPDIFRPGSYTDPYAQPPLTPRPQ-------PPPPESCCALPPRSLPSDPFS 2409

Query: 96   -LPEGLSSQALSTEAPLPATLEPRIVMGEETCQALLSPRAARTALRDQEGGHASPDP--- 151
             +P    SQ+ S+++PL     PR +  E  C + ++PR              SPDP   
Sbjct: 2410 RVPASPQSQS-SSQSPLT----PRPLSAEAFCPSPVTPR------------FQSPDPYSR 2452

Query: 152  PPELCSQGD----LSVPSPPPDPDSFFTPPSTP-TKTTYALLPACGPHGDARDSEAELRD 206
            PP      D    L  P  P  P+  F   S   T       PA  P G A +  A++  
Sbjct: 2453 PPSRPQSRDPFAPLHKPPRPQPPEVAFKAGSLAHTSLGAGGFPAALPAGPAGELHAKVPS 2512

Query: 207  ELLDSPPASP-SGSYITADGDSWASSPSC----SLSLLAPAEGLDFPSGWGL-------- 253
                +   SP +G+++        + P      SL    P  GL  P G           
Sbjct: 2513 GQPPNFVRSPGTGAFVGTPSPMRFTFPQAVGEPSLKPPVPQPGLPPPHGINSHFGPGPTL 2572

Query: 254  -SPQGS--MVDERELHPAGTPEPPSSESS 279
              PQ +   V     HP+G+P  PSS S+
Sbjct: 2573 GKPQSTNYTVATGNFHPSGSPLGPSSGST 2601



 Score = 31.2 bits (69), Expect = 8.2
 Identities = 83/340 (24%), Positives = 111/340 (32%), Gaps = 37/340 (10%)

Query: 13  PEADRPGPRTDLSCDAAAATTILGGDRREPCALTPGPSHLALTFLPSKPGARPQPEGASW 72
           PEA R  P  + S  +            E   L P      L+  P +    P PE +  
Sbjct: 567 PEASRLSPPPEESPMSPPPEESPMSPPPEASRLFPPFEESPLSPPPEESPLSPPPEASRL 626

Query: 73  DAGPGGAPSAWADPGEGGPSPMLLPEGLSSQALSTEAPLPATLEPRIVMGEETCQALLSP 132
              P  +P +   P E   SP   PE      +S  +PLP     R+    E       P
Sbjct: 627 SPPPEDSPMS-PPPEESPMSPP--PE------VSRLSPLPVV--SRLSPPPEESPLSPPP 675

Query: 133 RAARTALRDQEGGHASPDPPPELCSQGDLSVPSPPPDPDSFFT-----PPSTPTKTTYAL 187
             + T+    E    SP P     S      P+ PP  DS  +      P  P      L
Sbjct: 676 EESPTS-PPPEASRLSPPPEDSPTSPPPEDSPASPPPEDSLMSLPLEESPLLPLPEEPQL 734

Query: 188 LPAC-GPHGDARDSEAELRDELLDSPPASPSGSYITADGDSWASSPSCSLSLLAPAEGLD 246
            P   GPH   R  E  L     + P  SP      A+    +  P        P E   
Sbjct: 735 CPRSEGPHLSPRPEEPHLSPR-PEEPHLSPQ-----AEEPHLSPQPEEPCLCAVPEEPHL 788

Query: 247 FPSGWG--LSPQGSMVDERELHPAGTPEPPSSESSLSADSSSSWGQEGHFFDLDFLANDP 304
            P   G  LSPQ       ELH +   E P           S   +E H   L   + +P
Sbjct: 789 SPQAEGPHLSPQ-----PEELHLSPQTEEPHLSPVPEEPCLSPQPEESH---LSPQSEEP 840

Query: 305 MIPAALLPFQGSLIFQVEAVEVTPLSPEEEEEEAVADPDP 344
            +     P +  L  ++E   ++P  PE+  EE    P P
Sbjct: 841 CLSPR--PEESHLSPELEKPPLSP-RPEKPPEEPGQCPAP 877


>gi|91982772 mucin 17 [Homo sapiens]
          Length = 4493

 Score =  102 bits (253), Expect = 4e-21
 Identities = 215/954 (22%), Positives = 341/954 (35%), Gaps = 167/954 (17%)

Query: 509  EETDSTAGQESAAMAMPQPSQEGISEILGQESVTAEKLPTPQEETSLT------------ 556
            E+T S    E   + M  PS+E IS  +    V+   LP+ +  TSLT            
Sbjct: 134  EDTSSPTTPEGTDVPMSTPSEESISSTMA--FVSTAPLPSFEAYTSLTYKVDMSTPLTTS 191

Query: 557  -------LCPDS---PQNLKEEGGLDLPSGRKPVAAATIVPRQAKEDLTLPQD------- 599
                     P+S   P++   EG   L S   P +   +   +A   LT P +       
Sbjct: 192  TQASSSPTTPESTTIPKSTNSEGSTPLTS--MPASTMKVASSEAITLLTTPVEISTPVTI 249

Query: 600  --SAMTPPLPLQDTDLS-SAPK---------PVAAATIVSQQAEEGLTLPQDSVMTPPLP 647
               A + P   +   LS SAP          P++   +VS +A    TL      T    
Sbjct: 250  SAQASSSPTTAEGPSLSNSAPSGGSTPLTRMPLSVMLVVSSEAS---TLSTTPAATNIPV 306

Query: 648  LQDTELSSAPKPVAAATLVSQQAEEGLTLPQDSAMTPPLPLQDTDLSS-APKPVAAATLV 706
            +  TE SS+P      ++ +    EG T P  S     +P+  +++S+ +  PV  +TLV
Sbjct: 307  ITSTEASSSPTTAEGTSIPTSTYTEGST-PLTSTPASTMPVATSEMSTLSITPVDTSTLV 365

Query: 707  SQQAEEG---LTLPQDSAMTPPLPLQDTDLSSAPKPVAAATLVSQQAEEGLTLPQDS--- 760
            +   E      T    S +T  L    T L++   PV+   + S +A    T+P DS   
Sbjct: 366  TTSTEPSSLPTTAEATSMLTSTLSEGSTPLTN--MPVSTILVASSEASTTSTIPVDSKTF 423

Query: 761  ------AMTPPLPLQDTDLSSA----------PKPVAAATIVSQQAEEGLTLPQDSAMTP 804
                  A + P   +DT ++++            PV+   + S +A    T P DS    
Sbjct: 424  VTTASEASSSPTTAEDTSIATSTPSEGSTPLTSMPVSTTPVASSEASNLSTTPVDSKTQ- 482

Query: 805  PLPLQDTDLSSAPKPVAAATIVSQQAEEGLTLPQDSAMTPPLPLQDTDLSS-APKPVAAA 863
                  T+ SS+P      ++ +    EG T P  S     +P+  ++ S+ +  PV  +
Sbjct: 483  --VTTSTEASSSPPTAEVNSMPTSTPSEGST-PLTSMSVSTMPVASSEASTLSTTPVDTS 539

Query: 864  TPV--SQQAEEGLTLPQDSAMTPPLPLQ-DTDLSSAPKPVAAATPVSQQAEEGLTLPQDS 920
            TPV  S +A    T P+ +++    P +  T L++   PV+    VS +A    T P DS
Sbjct: 540  TPVTTSSEASSSSTTPEGTSIPTSTPSEGSTPLTN--MPVSTRLVVSSEASTTSTTPADS 597

Query: 921  AMTAPLPLQDTGPTSGPEPLAVATPQTLQAEAGCAPGTEPVATMAQQEVGEALGPRPAPE 980
                    + +  ++  E    + P +  +E G    +  V+T       EA      P 
Sbjct: 598  NTFVTTSSEASSSSTTAE--GTSMPTSTYSERGTTITSMSVSTTLVAS-SEASTLSTTPV 654

Query: 981  EKNAALPTVPEPAALDQVQQDDPQPAA---EAGTP---------WAAQEDADS------- 1021
            + N  + T  E  +     +    P +   E  TP           A  +A +       
Sbjct: 655  DSNTPVTTSTEATSSSTTAEGTSMPTSTYTEGSTPLTSMPVNTTLVASSEASTLSTTPVD 714

Query: 1022 -----TLGMEALSLPEPASGA-------GEEIAEALSRPGREACL-EARAHTGDGAKPDS 1068
                 T   EA S P  A GA        E      S P  +  L  + A T      D+
Sbjct: 715  TSTPVTTSTEASSSPTTADGASMPTSTPSEGSTPLTSMPVSKTLLTSSEASTLSTTPLDT 774

Query: 1069 PQKETLEVE-----NQQEGGLKPLAQEHGPRSALGGAREVP-DAPPAACPEVSQARLL-- 1120
                T   E        EG   P++    P         +P    P   PE S       
Sbjct: 775  STHITTSTEASCSPTTTEGTSMPIST---PSEGSPLLTSIPVSITPVTSPEASTLSTTPV 831

Query: 1121 ---SPAREERGLSGKSTPE--PTLPSAVATE--ASLDSCPES----SVGAVSSLDRGCPD 1169
               SP      +S   TP    ++P++  +E    L S P S    +  A+S+L     D
Sbjct: 832  DSNSPVTTSTEVSSSPTPAEGTSMPTSTYSEGRTPLTSMPVSTTLVATSAISTLSTTPVD 891

Query: 1170 APAPTSAPTSQQPEPVLGLGSVEQPHEVPSVLGTPLLQPPENL-------AKGQPSTPVD 1222
               P +  T  +  P    G+   P   P    TPL   P++        A+   +TPVD
Sbjct: 892  TSTPVTNSTEARSSPTTSEGT-SMPTSTPGEGSTPLTSMPDSTTPVVSSEARTLSATPVD 950

Query: 1223 --RPLGPD---PSAPGTLAGAALP---PLEPPAPCLCQDPQEDSVEDEEPPGSLGLPPPQ 1274
               P+       S+P T  G ++P   P E   P L   P   ++       +L   P  
Sbjct: 951  TSTPVTTSTEATSSPTTAEGTSIPTSTPSEGTTP-LTSTPVSHTLVANSEASTLSTTPVD 1009

Query: 1275 AGVQPAAAAVSGTTQPLGTGPRVSLSPHS---------PLLSPKVASMDAKDLA 1319
            +      +  + +  P   G  +  S  S         P+ +  VAS +   L+
Sbjct: 1010 SNTPLTTSTEASSPPPTAEGTSMPTSTPSEGSTPLTRMPVSTTMVASSETSTLS 1063



 Score = 99.0 bits (245), Expect = 3e-20
 Identities = 223/1083 (20%), Positives = 371/1083 (34%), Gaps = 138/1083 (12%)

Query: 468  VTEEGLALGQESTATVTPHTLQVAPGLQVEVATRVTPQAGEEETDSTAGQESAAMAMPQP 527
            V+   +A  + ST + TP          V+ +  VT       + +TA   S  ++ P  
Sbjct: 2876 VSTTPVASSEASTLSTTP----------VDTSIPVTTSTEGSSSPTTAEGTSMPISTPSE 2925

Query: 528  SQEGISEIL-------GQESVTAEKLPTPQEETSLTLCPDSPQNLKEEGGLDLPSG---- 576
                ++ IL       G E+ T    P     T +T   ++  +     G  +P      
Sbjct: 2926 VSTPLTSILVSTVPVAGSEASTLSTTPV-DTRTPVTTSAEASSSPTTAEGTSMPISTPGE 2984

Query: 577  -RKPVAAATI--VPRQAKEDLTLPQDSAMTPPLPLQDTDLSSAPKPVAAATIVSQQAEEG 633
             R P+ + ++  +P  + E  TL +  A T       T+ SS+P       I      EG
Sbjct: 2985 RRTPLTSMSVSTMPVASSEASTLSRTPADTSTPVTTSTEASSSPTTAEGTGIPISTPSEG 3044

Query: 634  LT-LPQDSVMTPPLPLQDTE-LSSAP----KPVAAATLVSQQAE--EGLTLPQDSAMTPP 685
             T L    V T P+ + +   LS+ P     PV  +T VS      EG ++P  +     
Sbjct: 3045 STPLTSIPVSTTPVAIPEASTLSTTPVDSNSPVVTSTEVSSSPTPAEGTSMPISTYSEGS 3104

Query: 686  LPLQDTDLSSAPKPVAAATLVSQQAEEGLTLPQDSAMTPPLPLQDTDLSSAPKPVAAATL 745
             PL    +S+ P   +A + +S       T P D++ TP      T+  S+P      ++
Sbjct: 3105 TPLTGVPVSTTPVTSSAISTLS-------TTPVDTS-TPVTT--STEAHSSPTTSEGTSM 3154

Query: 746  VSQQAEEGLTLPQDSAMTPPLPLQDTDLSSAPKPVAAATIVSQQAE-------EGLTLPQ 798
             +    EG T      ++  L +   D + +  PV  +T V+   E       EG ++P 
Sbjct: 3155 PTSTPSEGSTPLTYMPVSTMLVVSSEDSTLSATPVDTSTPVTTSTEATSSTTAEGTSIPT 3214

Query: 799  DSAMTPPLPLQDTDLSSAPKPVAAATIVSQQAEEG---LTLPQDSAMTPP------LPLQ 849
             +      PL    +S+ P   + A+I+S    +    LT   +++ +PP      +P  
Sbjct: 3215 STPSEGMTPLTSVPVSNTPVASSEASILSTTPVDSNTPLTTSTEASSSPPTAEGTSMPTS 3274

Query: 850  DTDLSSAP---KPVAAATPVSQQAEEGLTLPQDSAMTPPLPLQDTDLSSAPKPVAAAT-- 904
                 S P    PV+  T  S +     T P D++     P+     +S+  P+A  T  
Sbjct: 3275 TPSEGSTPLTSMPVSTTTVASSETSTLSTTPADTST----PVTTYSQASSSPPIADGTSM 3330

Query: 905  PVSQQAEEGLTLPQDSAMTAPLPLQDTGPTSGPEPLAVATPQTLQAEAGCAPGTEPVATM 964
            P S  +E    L   S  T P+ +     T    P+  +TP T   EA  +P T    ++
Sbjct: 3331 PTSTYSEGSTPLTNMSFSTTPV-VSSEASTLSTTPVDTSTPVTTSTEASLSPTTAEGTSI 3389

Query: 965  AQQEVGEALGPRPAPEEKNAALPTVPEPAALDQVQQDDPQPAAEAGTPWAAQEDADSTLG 1024
                  E   P        A++P    P    +V      P         + E + S   
Sbjct: 3390 PTSSPSEGTTPL-------ASMPVSTTPVVSSEVNTLSTTPVDSNTLVTTSTEASSSPTI 3442

Query: 1025 MEALSLPEPASGAG---------------EEIAEALSRPGREACLEARAHTGDGAKPDSP 1069
             E  SLP   +  G                  A  LS    +        +   + P + 
Sbjct: 3443 AEGTSLPTSTTSEGSTPLSIMPLSTTPVASSEASTLSTTPVDTSTPVTTSSPTNSSPTTA 3502

Query: 1070 QKETLEVENQQEGGL----KPLAQEHGPRSALGGAREVPDAPPAACPEVSQARLLSPARE 1125
            +  ++      EG       P++      S        P          SQA   SPA  
Sbjct: 3503 EVTSMPTSTAGEGSTPLTNMPVSTTPVASSEASTLSTTPVDSNTFVTSSSQAS-SSPATL 3561

Query: 1126 ERGLSGKSTPEPTLPS--AVATEASLDSCPESSVGAVSSLDRGCPDAPAPTSAPTSQQPE 1183
            +      STP     S   +   ++  +  E+S  +  S+DR  P   +  S  T   PE
Sbjct: 3562 QVTTMRMSTPSEGSSSLTTMLLSSTYVTSSEASTPSTPSVDRSTPVTTSTQSNSTPTPPE 3621

Query: 1184 PVLGLGSVEQPHEVPSVLGTPLLQPPENLAK------GQPST-PVDRPL-----GPDPSA 1231
                   +  P   PS + TPL   P +         G  ST PVD            S+
Sbjct: 3622 ------VITLPMSTPSEVSTPLTIMPVSTTSVTISEAGTASTLPVDTSTPVITSTQVSSS 3675

Query: 1232 PGTLAGAALP---PLEPPAPCLCQDPQEDSVEDEEPPGSLGLPPPQAGVQPAAAAVSGTT 1288
            P T  G  +P   P E   P          V   E  GS    P      P    V+ +T
Sbjct: 3676 PVTPEGTTMPIWTPSEGSTPLTTMPVSTTRVTSSE--GSTLSTPSVVTSTP----VTTST 3729

Query: 1289 QPLGTGPRVSLSPHSPLLSPKVASMDAKDLALQILPPCQVPPPSGPQSPAGPQGLSAPEQ 1348
            + + +   +  +  S  +  +++++    + +   P  + P  S P  P+    +S    
Sbjct: 3730 EAISSSATLDSTTMSVSMPMEISTL-GTTILVSTTPVTRFPESSTPSIPSVYTSMSMTTA 3788

Query: 1349 QEDEDSLEEDSPRAL-GSGQHSDSHGESSAELDEQDILAPQTVQCPAQA------PAGGS 1401
             E        SP  L G+     S     + L    +++P +V  P++A      P   S
Sbjct: 3789 SEG-----SSSPTTLEGTTTMPMSTTSERSTLLTTVLISPISVMSPSEASTLSTPPGDTS 3843

Query: 1402 EETIAKAKQSRSEKKARKAMSKLGLRQIQGVTRITIQKSKNILFVIAKPDVFKSPASDTY 1461
               +   K       A     ++ +   +     T+  S  +        +  +P  DT 
Sbjct: 3844 TPLLTSTKAGSFSIPAEVTTIRISITSERSTPLTTLLVSTTLPTSFPGASIASTPPLDTS 3903

Query: 1462 VVF 1464
              F
Sbjct: 3904 TTF 3906



 Score = 93.6 bits (231), Expect = 1e-18
 Identities = 278/1320 (21%), Positives = 453/1320 (34%), Gaps = 193/1320 (14%)

Query: 165  SPPPDPDSFFTPPSTPTKTTYALLPACGPHGDARDSEAELRDELLDSPPASPSGSYITAD 224
            S P   +    P STP++ T  L      H    +SEA      L + P   S + +T  
Sbjct: 963  SSPTTAEGTSIPTSTPSEGTTPLTSTPVSHTLVANSEAST----LSTTPVD-SNTPLTTS 1017

Query: 225  GDSWASSPSC---SLSLLAPAEGLDFPSGWGLSPQ---GSMVDERELHPAGTPEPPSSES 278
             ++ +  P+    S+    P+EG    +   +S      S        PA T  P ++ S
Sbjct: 1018 TEASSPPPTAEGTSMPTSTPSEGSTPLTRMPVSTTMVASSETSTLSTTPADTSTPVTTYS 1077

Query: 279  SLSADSSSSWGQEGHFFDLDFLANDPMIPAALLPFQGSLIFQVEA--VEVTPLS---PEE 333
              S+ S+++ G            ++   P   +P    L+   EA  +  TP+    P  
Sbjct: 1078 QASSSSTTADGTSMPTSTY----SEGSTPLTSVPVSTRLVVSSEASTLSTTPVDTSIPVT 1133

Query: 334  EEEEAVADPDPGGDLAGEGEEDSTSASFLQSLSDLSITEGMDEAFAFR-----DDTSAAS 388
               EA + P      +      S   + L S+   +      EA           T  A+
Sbjct: 1134 TSTEASSSPTTAEGTSIPTSPPSEGTTPLASMPVSTTLVVSSEANTLSTTPVDSKTQVAT 1193

Query: 389  SDSDSASYAEADDERLYSGEPHAQATLLQDSVQKTEEESGGGAKGLQAQDGTVSWAVEAA 448
            S   S+    A+   + +  P  ++T L     +    +   A  L       S  V  +
Sbjct: 1194 STEASSPPPTAEVTSMPTSTPGERSTPLTSMPVRHTPVASSEASTLSTSPVDTSTPVTTS 1253

Query: 449  PQTSDRGAYLSQRQELISEVTEEGLAL-------------GQESTATVTPHTLQVAPGLQ 495
             +TS      ++   L +  T EG  L              + ST   TP   +      
Sbjct: 1254 AETSSSPT-TAEGTSLPTSTTSEGSTLLTSIPVSTTLVTSPEASTLLTTPVDTKGPVVTS 1312

Query: 496  VEVATRVTPQAGEEETDSTAGQESAAM-AMPQPSQEGISEILGQESVTAEKLPTPQEETS 554
             EV++  TP  G     ST  +    + ++P  +    S  +   S T     TP   TS
Sbjct: 1313 NEVSSSPTPAEGTSMPTSTYSEGRTPLTSIPVNTTLVASSAISILSTTPVDNSTPVT-TS 1371

Query: 555  LTLCPDS--------PQNLKEEGGLDLPSGRKPVAAATIVPRQAKEDLTLPQDSAMTPPL 606
               C           P +   EG   L S   PV+   +V  +A      P D+      
Sbjct: 1372 TEACSSPTTSEGTSMPNSNPSEGTTPLTS--IPVSTTPVVSSEASTLSATPVDT------ 1423

Query: 607  PLQDTDLSSAPKPVAAATIVSQQAEEGLTLPQDSVMTPPLPLQDTELSSAPKPVAAATLV 666
                    S P   +A    S    EG+++P  +      PL+   +S+ P   + A+ +
Sbjct: 1424 --------STPGTTSAEATSSPTTAEGISIPTSTPSEGKTPLKSIPVSNTPVANSEASTL 1475

Query: 667  SQQAEEGLTLPQDSAMTPPLPLQDTDLSSAPKPVAAATLVSQQAEEGLTLPQDSAMTPPL 726
            S       T P DS    P+ +  T +SS+P P    ++      EG T     A+T  +
Sbjct: 1476 S-------TTPVDS--NSPV-VTSTAVSSSPTPAEGTSIAISTPSEGST-----ALTS-I 1519

Query: 727  PLQDTDLSSAP------KPVAAATLV---SQQAEEGLTLPQDSAMTPPLPLQDTDLSSAP 777
            P+  T ++S+        P   +T V   SQ +    T    S  T       T L+S P
Sbjct: 1520 PVSTTTVASSEINSLSTTPAVTSTPVTTYSQASSSPTTADGTSMQTSTYSEGSTPLTSLP 1579

Query: 778  KPVAAATIVSQQAEEGLTLPQDS-------------------AMTPPLPLQDTDLSSAPK 818
              V+   +VS +A    T P DS                   +MT   P + + L ++  
Sbjct: 1580 --VSTMLVVSSEANTLSTTPIDSKTQVTASTEASSSTTAEGSSMTISTPSEGSPLLTSI- 1636

Query: 819  PVAAATIVSQQAEEGLTLPQDSAMTPPLPLQDTDLSSAPKPVAAATPVSQQAEEGLTLPQ 878
            PV+   + S +A    T P DS    P+ +  T++SS+P P    +  +    EG T P 
Sbjct: 1637 PVSTTPVASPEASTLSTTPVDS--NSPV-ITSTEVSSSPTPAEGTSMPTSTYTEGRT-PL 1692

Query: 879  DSAMTPPLPLQDTDLSS-APKPVAAATPVSQQAE--------EGLTLPQDSAMTAPLPLQ 929
             S      P+  + +S+ +  PV  +TPV+   E        EG ++P  +      PL 
Sbjct: 1693 TSITVRTTPVASSAISTLSTTPVDNSTPVTTSTEARSSPTTSEGTSMPNSTPSEGTTPLT 1752

Query: 930  DTGPTSGP-----------EPLAVATPQTLQAEAGCAPGTEPVATMAQQEVGEALGPRPA 978
                ++ P            P+  +TP T   EA  +P T    ++    + E + P  +
Sbjct: 1753 SIPVSTTPVLSSEASTLSATPIDTSTPVTTSTEATSSPTTAEGTSIPTSTLSEGMTPLTS 1812

Query: 979  --------PEEKNAALPTVP----EPAALDQVQQDDPQPAAEAGTPWAAQEDADSTLGME 1026
                       + + L T P     P          P PA   GT  A    ++ +  + 
Sbjct: 1813 TPVSHTLVANSEASTLSTTPVDSNSPVVTSTAVSSSPTPA--EGTSIATSTPSEGSTAL- 1869

Query: 1027 ALSLPEPASGAGEEIAEALSRPGREACLEARAHTGDGAKPDSPQKETLEVENQQEGGLKP 1086
              S+P   +         LS            +    + P +    ++     +EG  +P
Sbjct: 1870 -TSIPVSTTTVASSETNTLSTTPAVTSTPVTTYAQVSSSPTTADGSSMPTSTPREG--RP 1926

Query: 1087 LAQEHGPRSALGGAREVPDAPPAACPEVSQARLLSPAREERGLSGKSTPEPT-LPSAVAT 1145
                    +    + E+           +     S A      S  +T + T +P+   +
Sbjct: 1927 PLTSIPVSTTTVASSEINTLSTTLADTRTPVTTYSQAS-----SSPTTADGTSMPTPAYS 1981

Query: 1146 EAS--LDSCPESSVGAVSSLDRGCPDAPAPTSAPTSQQPE----PVLGLGSVEQPHEVPS 1199
            E S  L S P S+   VSS        P  TS P +   E    P    G+  Q    PS
Sbjct: 1982 EGSTPLTSMPLSTTLVVSSEASTLSTTPVDTSTPATTSTEGSSSPTTAGGTSIQT-STPS 2040

Query: 1200 VLGTPLLQPPENL-----AKGQ--PSTPVDRPL----GPDPSAPGTLAGAALPPLEPP-- 1246
               TPL   P +      ++G    +TPVD         + S+  T  G+++    P   
Sbjct: 2041 ERTTPLAGMPVSTTLVVSSEGNTLSTTPVDSKTQVTNSTEASSSATAEGSSMTISAPSEG 2100

Query: 1247 APCLCQDPQEDSVEDEEPPGSLGLPPPQAGVQPAAAAVSGTTQPLGT-GPRVSLSPHS-- 1303
            +P L   P   +        +L   P  +   P   +   ++ P+ T G  +  S +S  
Sbjct: 2101 SPLLTSIPLSTTPVASPEASTLSTTPVDSN-SPVITSTEVSSSPIPTEGTSMQTSTYSDR 2159

Query: 1304 --PLLSPKVASMDAKDLALQIL--PPCQVPPP-----SGPQSPAGPQGLSAPEQQEDEDS 1354
              PL S  V++      A+  L   P     P         SP   +G S P     E S
Sbjct: 2160 RTPLTSMPVSTTVVASSAISTLSTTPVDTSTPVTNSTEARSSPTTSEGTSMPTSTPSEGS 2219



 Score = 91.3 bits (225), Expect = 7e-18
 Identities = 325/1483 (21%), Positives = 496/1483 (33%), Gaps = 237/1483 (15%)

Query: 63   ARPQPEGASWDAGPGGAPSAWADPGEGGP---SPMLLPEG--LSSQALSTEAPLP----A 113
            AR  P  +   + P   PS    P    P   +P+L  E   LS+  + T  P+     A
Sbjct: 1727 ARSSPTTSEGTSMPNSTPSEGTTPLTSIPVSTTPVLSSEASTLSATPIDTSTPVTTSTEA 1786

Query: 114  TLEPRIVMG--------EETCQALLSPRAARTALRDQEGGHASPDP----PPELCSQGDL 161
            T  P    G         E    L S   + T + + E    S  P     P + S    
Sbjct: 1787 TSSPTTAEGTSIPTSTLSEGMTPLTSTPVSHTLVANSEASTLSTTPVDSNSPVVTSTAVS 1846

Query: 162  SVPSPPPDPDSFFTPPSTPTKTTYAL--LPACGPHGDARDSEAELRDELLDSPP----AS 215
            S P+P    +      STP++ + AL  +P       + ++        + S P    A 
Sbjct: 1847 SSPTPA---EGTSIATSTPSEGSTALTSIPVSTTTVASSETNTLSTTPAVTSTPVTTYAQ 1903

Query: 216  PSGSYITADGDSWASSPSCSLSLLAPAEGLDFPSGWGLSPQGSMVDERELHPAGTP--EP 273
             S S  TADG S  +S         P EG   P    +    + V   E++   T   + 
Sbjct: 1904 VSSSPTTADGSSMPTS--------TPREGR--PPLTSIPVSTTTVASSEINTLSTTLADT 1953

Query: 274  PSSESSLSADSSSSWGQEGHFFDLDFLANDPMIPAALLPFQGSLIFQVEA--VEVTPL-- 329
             +  ++ S  SSS    +G        + +   P   +P   +L+   EA  +  TP+  
Sbjct: 1954 RTPVTTYSQASSSPTTADGTSMPTPAYS-EGSTPLTSMPLSTTLVVSSEASTLSTTPVDT 2012

Query: 330  -SPEEEEEEAVADPDPGGDLAGEGEEDSTSASFLQSLSDLSIT-------EGMDEAFAFR 381
             +P     E  + P   G   G   + ST +     L+ + ++       EG   +    
Sbjct: 2013 STPATTSTEGSSSPTTAG---GTSIQTSTPSERTTPLAGMPVSTTLVVSSEGNTLSTTPV 2069

Query: 382  DDTSAASSDSDSASYAEADDERLYSGEPHAQATLLQDSVQKTEEESGGGAKGLQA----- 436
            D  +  ++ ++++S A A+   +    P   + LL      T   +   A  L       
Sbjct: 2070 DSKTQVTNSTEASSSATAEGSSMTISAPSEGSPLLTSIPLSTTPVASPEASTLSTTPVDS 2129

Query: 437  -QDGTVSWAVEAAPQTSD-----RGAYLSQRQELIS-EVTEEGLALGQESTATVTPHTLQ 489
                  S  V ++P  ++        Y  +R  L S  V+   +A    ST + TP    
Sbjct: 2130 NSPVITSTEVSSSPIPTEGTSMQTSTYSDRRTPLTSMPVSTTVVASSAISTLSTTPVDTS 2189

Query: 490  VAPGLQVEVATRVTPQAGEEETDSTAGQESAAM-AMPQPSQEGISEILGQESVTAEKLPT 548
                   E  +  T   G     ST  + S    +MP  +   ++      S T     T
Sbjct: 2190 TPVTNSTEARSSPTTSEGTSMPTSTPSEGSTPFTSMPVSTMPVVTSEASTLSATPVDTST 2249

Query: 549  P-QEETSLTLCPDS------PQNLKEEGGLDLPSGRKPVAAATIVPRQAKEDLTLPQDSA 601
            P    T  T  P +      P +   EG   L S   PV+   +   +     T P DS 
Sbjct: 2250 PVTTSTEATSSPTTAEGTSIPTSTLSEGTTPLTS--IPVSHTLVANSEVSTLSTTPVDSN 2307

Query: 602  MTPPLPLQDTDLSSAPKPVAAATIV--SQQAEEGLTLPQDSVMTPPLPLQDTE-LSSAPK 658
                 P   +  +S+P P A  T +  S  +E    L +  V T  +   +T  LS+ P 
Sbjct: 2308 T----PFTTSTEASSPPPTAEGTSMPTSTSSEGNTPLTRMPVSTTMVASFETSTLSTTPA 2363

Query: 659  PVAAATLVSQQAEEGLTLPQDSAM-TPPLPLQDTDLSSAPKPVAAATLVSQQAEEGLTLP 717
              +       QA    T   D++M T       T L+S P  V+   +VS +A    T P
Sbjct: 2364 DTSTPVTTYSQAGSSPTTADDTSMPTSTYSEGSTPLTSVP--VSTMPVVSSEASTHSTTP 2421

Query: 718  QDS---------AMTPPLPLQDTDLSSAPK----------PVAAATLVSQQAEEGLTLPQ 758
             D+         A + P   + T + ++P           PV+   +VS +A    T P 
Sbjct: 2422 VDTSTPVTTSTEASSSPTTAEGTSIPTSPPSEGTTPLASMPVSTTPVVSSEAGTLSTTPV 2481

Query: 759  DSAMTPPLPLQDTDLSSAPKPVAAATIVSQQAEEGLTLPQDSAM--TPPLPLQDTDLSSA 816
            D++ TP      T+ SS+P       +    A EG TL     +  TP    + + LS+ 
Sbjct: 2482 DTS-TPMTT--STEASSSPTTAEDIVVPISTASEGSTLLTSIPVSTTPVASPEASTLSTT 2538

Query: 817  P----KPVAAATIVSQQAE--EGLTLPQDSAMTPPLPLQDTDLSSAP-----------KP 859
            P     PV  +T +S  A   EG ++P  +      PL+   +S+ P            P
Sbjct: 2539 PVDSNSPVVTSTEISSSATSAEGTSMPTSTYSEGSTPLRSMPVSTKPLASSEASTLSTTP 2598

Query: 860  VAAATPVSQQAEEGL--TLPQDSAMTPPLPLQ-DTDLSS---APKPVAAA-------TPV 906
            V  + PV+   E     T  +D++M    P +  T L+S   +  PVA++       TPV
Sbjct: 2599 VDTSIPVTTSTETSSSPTTAKDTSMPISTPSEVSTSLTSILVSTMPVASSEASTLSTTPV 2658

Query: 907  --------------SQQAEEGLTLPQDSAMTAPLPLQDT-----------GPTSGPEPLA 941
                          S    EG ++P  +      PL +              T    P+ 
Sbjct: 2659 DTRTLVTTSTGTSSSPTTAEGSSMPTSTPGERSTPLTNILVSTTLLANSEASTLSTTPVD 2718

Query: 942  VATPQTLQAEAGCAPGTEPVATMAQQEVGEALGPRPAPEEKNAALPTVPEPAALDQVQQD 1001
             +TP T  AEA  +P T    +M      +  G  P      + LP     A+       
Sbjct: 2719 TSTPVTTSAEASSSPTTAEGTSMRISTPSD--GSTPLTSILVSTLPVASSEASTVSTTAV 2776

Query: 1002 DPQPAAEAGTPWAAQEDADSTLGMEALSLPEPASGAGEEIAEALSRPGREACLEARAHTG 1061
            D        T     E + S    E  S+  P S   E      S P     +   A + 
Sbjct: 2777 DTSIPVTTST-----EASSSPTTAEVTSM--PTSTPSETSTPLTSMPVNHTPV---ASSE 2826

Query: 1062 DGAKPDSPQKETLEVENQQEGGLKPLAQEH---GPRSALGGAREVPDAPPAACPEV-SQA 1117
             G    +P   +  V    +    P   E       +A  G+  +   P +  P   S+A
Sbjct: 2827 AGTLSTTPVDTSTPVTTSTKASSSPTTAEGIVVPISTASEGSTLLTSIPVSTTPVASSEA 2886

Query: 1118 RLLSP---------AREERGLSGKSTPEPT-LPSAVATEAS--LDSCPESSVGAVSSLDR 1165
              LS               G S  +T E T +P +  +E S  L S   S+V    S   
Sbjct: 2887 STLSTTPVDTSIPVTTSTEGSSSPTTAEGTSMPISTPSEVSTPLTSILVSTVPVAGSEAS 2946

Query: 1166 GCPDAPAPTSAPTSQQPE-------------PVLGLGSVEQPHEVPSVLGTPLLQPPENL 1212
                 P  T  P +   E             P+   G    P    SV   P+     + 
Sbjct: 2947 TLSTTPVDTRTPVTTSAEASSSPTTAEGTSMPISTPGERRTPLTSMSVSTMPVASSEAST 3006

Query: 1213 AKGQP---STPVDRPLGPDPSAPGTLAGAALP---PLEPPAPCLCQDP--------QEDS 1258
                P   STPV        S+P T  G  +P   P E   P L   P         E S
Sbjct: 3007 LSRTPADTSTPVTTSTEAS-SSPTTAEGTGIPISTPSEGSTP-LTSIPVSTTPVAIPEAS 3064

Query: 1259 VEDEEPPGSLGLPPPQAGVQPAAAAVSGTTQPLGTGPRVSLSPHSPLLSPKVASMDAKDL 1318
                 P  S         V  +     GT+ P+ T    S    +PL    V++      
Sbjct: 3065 TLSTTPVDSNSPVVTSTEVSSSPTPAEGTSMPISTYSEGS----TPLTGVPVSTTPVTSS 3120

Query: 1319 ALQIL--PPCQVPPP-----SGPQSPAGPQGLSAPEQQEDEDS 1354
            A+  L   P     P         SP   +G S P     E S
Sbjct: 3121 AISTLSTTPVDTSTPVTTSTEAHSSPTTSEGTSMPTSTPSEGS 3163



 Score = 89.4 bits (220), Expect = 3e-17
 Identities = 263/1192 (22%), Positives = 402/1192 (33%), Gaps = 158/1192 (13%)

Query: 211  SPPASPSGSYITADGDSWASSPSCSLSLLAPAEGLDFPSGWGLSPQGSMVDERELHPAGT 270
            S P +P  + I    +S  S+P  S+    PA  +   S   ++               T
Sbjct: 196  SSPTTPESTTIPKSTNSEGSTPLTSM----PASTMKVASSEAITL------------LTT 239

Query: 271  PEPPSSESSLSADSSSS-WGQEGHFFDLDFLANDPMIPAALLPFQGSLIFQVEA--VEVT 327
            P   S+  ++SA +SSS    EG     +   +    P   +P    L+   EA  +  T
Sbjct: 240  PVEISTPVTISAQASSSPTTAEGPSLS-NSAPSGGSTPLTRMPLSVMLVVSSEASTLSTT 298

Query: 328  PLS---PEEEEEEAVADPDPGGDLAGEGEEDSTSASFLQSLSDLSITEGMDEAFAFRDDT 384
            P +   P     EA + P        EG    TS          + TEG     +    T
Sbjct: 299  PAATNIPVITSTEASSSPT-----TAEGTSIPTS----------TYTEGSTPLTSTPAST 343

Query: 385  S-AASSDSDSASYAEADDERLY--SGEPHAQATLLQDSVQKTEEESGGGAKGLQAQDGTV 441
               A+S+  + S    D   L   S EP +  T  + +   T   S G          T+
Sbjct: 344  MPVATSEMSTLSITPVDTSTLVTTSTEPSSLPTTAEATSMLTSTLSEGSTPLTNMPVSTI 403

Query: 442  SWAVEAAPQTSDRGAYLSQRQELISEVTEEGLALGQESTATVTPHTLQVAPGLQVEVATR 501
              A   A  TS             SE +         S AT TP      P   + V+T 
Sbjct: 404  LVASSEASTTSTIPVDSKTFVTTASEASSSPTTAEDTSIATSTPSEGST-PLTSMPVST- 461

Query: 502  VTPQAGEEETDSTAGQESAAMAMPQPSQEGISEILGQESVTAEKLPTPQE-ETSLTLCPD 560
             TP A  E ++ +     +   +   ++   S    +  V +    TP E  T LT    
Sbjct: 462  -TPVASSEASNLSTTPVDSKTQVTTSTEASSSPPTAE--VNSMPTSTPSEGSTPLTSMSV 518

Query: 561  SPQNLKEEGGLDLPSGRKPVAAATIVPRQAKEDLTLPQDSAMTPPLPLQ-DTDLSSAPKP 619
            S   +       L +     +       +A    T P+ +++    P +  T L++ P  
Sbjct: 519  STMPVASSEASTLSTTPVDTSTPVTTSSEASSSSTTPEGTSIPTSTPSEGSTPLTNMP-- 576

Query: 620  VAAATIVSQQAEEGLTLPQDSVMTPPLPLQDTELSSAPKPVAAATLVSQQAEEGLTLPQD 679
            V+   +VS +A    T P DS        + +  S+  +  +  T  S  +E G T+   
Sbjct: 577  VSTRLVVSSEASTTSTTPADSNTFVTTSSEASSSSTTAEGTSMPT--STYSERGTTITSM 634

Query: 680  SAMTPPLPLQDTD-LSSAPKPVAAATLVSQQAEEGLTLPQDSAMTPPLPLQDTDLSSAPK 738
            S  T  +   +   LS+ P         S +A    T  + ++M P     +        
Sbjct: 635  SVSTTLVASSEASTLSTTPVDSNTPVTTSTEATSSSTTAEGTSM-PTSTYTEGSTPLTSM 693

Query: 739  PVAAATLVSQQAEEGLTLPQDSAMTPPLPLQDTDLSSAPKPVAAATIVSQQAEEGLTLPQ 798
            PV    + S +A    T P D++ TP      T+ SS+P     A++ +    EG T   
Sbjct: 694  PVNTTLVASSEASTLSTTPVDTS-TPVTT--STEASSSPTTADGASMPTSTPSEGSTPLT 750

Query: 799  DSAMTPPL--PLQDTDLSSAPKPVAAATIVSQQAEEGLTLPQDSAMTPPLPLQDTDLSSA 856
               ++  L    + + LS+ P   +     S +A    T  + ++M    P + + L ++
Sbjct: 751  SMPVSKTLLTSSEASTLSTTPLDTSTHITTSTEASCSPTTTEGTSMPISTPSEGSPLLTS 810

Query: 857  PKPVAAATPVSQQAEEGLTLPQDSAMTPPLPLQDTDLSSAPKPVAAATPVSQQAEEGLTL 916
              PV+     S +A    T P DS    P+    T++SS+P P    +  +    EG T 
Sbjct: 811  I-PVSITPVTSPEASTLSTTPVDS--NSPVTTS-TEVSSSPTPAEGTSMPTSTYSEGRTP 866

Query: 917  PQDSAMTAPLPLQDTGPTSGPEPLAVATPQTLQAEAGCAPGTEPVATMAQQEVGEALGPR 976
                 ++  L       T    P+  +TP T   EA  +P T    +M          P 
Sbjct: 867  LTSMPVSTTLVATSAISTLSTTPVDTSTPVTNSTEARSSPTTSEGTSM----------PT 916

Query: 977  PAPEEKNAALPTVPEPAALDQVQQDDPQPAAEAGTPWAAQEDADS--TLGMEALSLPEPA 1034
              P E +  L ++P+           P  ++EA T  A   D  +  T   EA S P  A
Sbjct: 917  STPGEGSTPLTSMPDSTT--------PVVSSEARTLSATPVDTSTPVTTSTEATSSPTTA 968

Query: 1035 SGAGEEIAEALSRPGREACLEARAHTGDGAKPDSPQKETLEVENQQEGGLKPLAQEHGPR 1094
             G     +   S P            G      +P   TL V N +   L     +    
Sbjct: 969  EGT----SIPTSTPSE----------GTTPLTSTPVSHTL-VANSEASTLSTTPVD--SN 1011

Query: 1095 SALGGAREVPDAPPAACPEVSQARLLSPAREERGLSGKSTPEPTLPSAVATEASLDSCPE 1154
            + L  + E    PP A                    G S P  T PS  +T   L   P 
Sbjct: 1012 TPLTTSTEASSPPPTA-------------------EGTSMPTST-PSEGST--PLTRMPV 1049

Query: 1155 SSVGAVSSLDRGCPDAPAPTSAPT---SQQPEPVLGLGSVEQPHEVPSVLGTPLLQPP-- 1209
            S+    SS        PA TS P    SQ             P    S   TPL   P  
Sbjct: 1050 STTMVASSETSTLSTTPADTSTPVTTYSQASSSSTTADGTSMPTSTYSEGSTPLTSVPVS 1109

Query: 1210 -----ENLAKGQPSTPVDRPL-----GPDPSAPGTLAGAAL---PPLEPPAPCLCQDPQE 1256
                  + A    +TPVD  +         S+P T  G ++   PP E   P L   P  
Sbjct: 1110 TRLVVSSEASTLSTTPVDTSIPVTTSTEASSSPTTAEGTSIPTSPPSEGTTP-LASMPVS 1168

Query: 1257 DSVEDEEPPGSLGLPPPQAGVQPAAAAVSG--------TTQPLGT-GPRVSLSPHSPLLS 1307
             ++       +L   P  +  Q A +  +         T+ P  T G R +     P+  
Sbjct: 1169 TTLVVSSEANTLSTTPVDSKTQVATSTEASSPPPTAEVTSMPTSTPGERSTPLTSMPVRH 1228

Query: 1308 PKVASMDAKDLALQILPPCQVPPP-----SGPQSPAGPQGLSAPEQQEDEDS 1354
              VAS +A  L+     P     P         SP   +G S P     E S
Sbjct: 1229 TPVASSEASTLSTS---PVDTSTPVTTSAETSSSPTTAEGTSLPTSTTSEGS 1277



 Score = 84.7 bits (208), Expect = 6e-16
 Identities = 255/1236 (20%), Positives = 412/1236 (33%), Gaps = 147/1236 (11%)

Query: 88   EGGPSPMLLPEGLS---SQALSTEAPLPATLEPRI-VMGEETCQALLSPRAARTALRDQE 143
            EG  SP    EG S   S       PL + L   + V G E      +P   RT +    
Sbjct: 2905 EGSSSPTTA-EGTSMPISTPSEVSTPLTSILVSTVPVAGSEASTLSTTPVDTRTPVTTS- 2962

Query: 144  GGHASPDPPPELCSQGDLSVPSPPPDPDSFFTPPSTPTKTTYALLPACGPHGDARDSEAE 203
               AS  P     +   +S P     P +  +  + P  ++ A   +  P   A  S   
Sbjct: 2963 -AEASSSPTTAEGTSMPISTPGERRTPLTSMSVSTMPVASSEASTLSRTP---ADTSTPV 3018

Query: 204  LRDELLDSPPASPSGSYITADGDSWASSPSCSLSLLAPAEGLDFPSGWGLSPQGS---MV 260
                   S P +  G+ I     S  S+P  S+ +      +   S    +P  S   +V
Sbjct: 3019 TTSTEASSSPTTAEGTGIPISTPSEGSTPLTSIPVSTTPVAIPEASTLSTTPVDSNSPVV 3078

Query: 261  DERELHPAGTPEPPSSESSLSADSSSSWGQEGHFFDLDFLANDPMIPAALLPFQGSLIFQ 320
               E+  + TP   +S   +S  S  S    G             +P +  P   S I  
Sbjct: 3079 TSTEVSSSPTPAEGTS-MPISTYSEGSTPLTG-------------VPVSTTPVTSSAIST 3124

Query: 321  VEAVEVTPLSPEEEEEEAVADPDPGGDLA---GEGEEDSTSASFLQSLSDLSITEGMDEA 377
            +    V   +P     EA + P      +       E ST  +++   + L ++      
Sbjct: 3125 LSTTPVDTSTPVTTSTEAHSSPTTSEGTSMPTSTPSEGSTPLTYMPVSTMLVVSSEDSTL 3184

Query: 378  FAFRDDTSA-ASSDSDSASYAEADDERLYSGEPHAQATLLQDSVQKTEEESGGGAKGLQA 436
             A   DTS   ++ +++ S   A+   + +  P    T L          +   A  L  
Sbjct: 3185 SATPVDTSTPVTTSTEATSSTTAEGTSIPTSTPSEGMTPLTSVPVSNTPVASSEASILST 3244

Query: 437  QDGTVSWAVEAAPQTSDRGAYLSQRQELISEVTEEGLALGQESTATVTPHTLQVAPGLQV 496
                 +  +  + + S             S  T EG ++   ST +     L   P    
Sbjct: 3245 TPVDSNTPLTTSTEASS------------SPPTAEGTSM-PTSTPSEGSTPLTSMPVSTT 3291

Query: 497  EVATRVTPQAGEEETDSTAGQESAAMAMPQPSQEGISEILGQESVTAEKLPTPQEETSLT 556
             VA+  T        D++    + + A   P    I++     + T  +  TP    S +
Sbjct: 3292 TVASSETSTLSTTPADTSTPVTTYSQASSSPP---IADGTSMPTSTYSEGSTPLTNMSFS 3348

Query: 557  LCP--DSPQNLKEEGGLDLPSGRKPVAAATIVPRQAKEDLTLPQDSAMTPPLPLQDTDLS 614
              P   S  +      +D  +       A++ P  A E  ++P  S      PL      
Sbjct: 3349 TTPVVSSEASTLSTTPVDTSTPVTTSTEASLSPTTA-EGTSIPTSSPSEGTTPL------ 3401

Query: 615  SAPKPVAAATIVSQQAEEGLTLPQDSVMTPPLPLQDTELSSAPKPVAAATLVSQQAEEGL 674
             A  PV+   +VS +     T P DS     L    TE SS+P      +L +    EG 
Sbjct: 3402 -ASMPVSTTPVVSSEVNTLSTTPVDS---NTLVTTSTEASSSPTIAEGTSLPTSTTSEG- 3456

Query: 675  TLPQDSAMTPPLPLQDTDLSSAPKPVAAATLVSQQAEEGLTLPQDSAMTPP----LPLQD 730
                 S     +PL  T ++S+     + T V        + P +S+ T      +P   
Sbjct: 3457 -----STPLSIMPLSTTPVASSEASTLSTTPVDTSTPVTTSSPTNSSPTTAEVTSMPTST 3511

Query: 731  TDLSSAP---KPVAAATLVSQQAEEGLTLPQDSAMTPPLPLQDTDLSSAPKPVAAATIVS 787
                S P    PV+   + S +A    T P DS          +  SS+P  +   T+  
Sbjct: 3512 AGEGSTPLTNMPVSTTPVASSEASTLSTTPVDSNT---FVTSSSQASSSPATLQVTTMRM 3568

Query: 788  QQAEEGLTLPQDSAMTPPLPLQDTDLSSAPKPVAAATIVSQQAEEGLTLPQDSAMTPP-- 845
                EG      S++T  L L  T ++S+     +   V +      +   +S  TPP  
Sbjct: 3569 STPSEG-----SSSLTTML-LSSTYVTSSEASTPSTPSVDRSTPVTTSTQSNSTPTPPEV 3622

Query: 846  --LPLQDTDLSSAP---KPVAAATPVSQQAEEGLTLPQDSAMTPPLPLQDTDLSSAPKPV 900
              LP+      S P    PV+  +    +A    TLP D++ TP +    T +SS+P   
Sbjct: 3623 ITLPMSTPSEVSTPLTIMPVSTTSVTISEAGTASTLPVDTS-TPVIT--STQVSSSPVTP 3679

Query: 901  AAATPVSQQAEEGLTLPQDSAMTAPLPLQDTGPTSGPEPLAVATPQTLQAEAGCAPGTEP 960
               T       EG T      ++        G T     +  +TP T   EA  +  T  
Sbjct: 3680 EGTTMPIWTPSEGSTPLTTMPVSTTRVTSSEGSTLSTPSVVTSTPVTTSTEAISSSATLD 3739

Query: 961  VATMAQQEVGE--------ALGPRPA---PEEKNAALPTVPEPAALDQVQQDDPQPAAEA 1009
              TM+     E         +   P    PE    ++P+V    ++    +    P    
Sbjct: 3740 STTMSVSMPMEISTLGTTILVSTTPVTRFPESSTPSIPSVYTSMSMTTASEGSSSPTTLE 3799

Query: 1010 GTPWAAQEDADSTLGMEALSLPEPASGAGEEIAEALSRPGREACLEARAHTGDGAKPDSP 1069
            GT             +    L  P S      A  LS P  +        T  G+     
Sbjct: 3800 GTTTMPMSTTSERSTLLTTVLISPISVMSPSEASTLSTPPGDTSTPLLTSTKAGSFSIPA 3859

Query: 1070 QKETLEVE--NQQEGGLKPLAQEHGPRSALGGAREVPDAPP-------------AACPEV 1114
            +  T+ +   +++   L  L       ++  GA  +   PP             A+ P +
Sbjct: 3860 EVTTIRISITSERSTPLTTLLVSTTLPTSFPGA-SIASTPPLDTSTTFTPSTDTASTPTI 3918

Query: 1115 SQARLLSPAREERGLSGKSTPEPT--LPSAVATEASLDSCPESSVGAVSS--LDRGCPDA 1170
              A  +S +    G    STP  T  +PS   T ++ D  P ++ GAVS+  +     + 
Sbjct: 3919 PVATTISVSVITEG----STPGTTIFIPSTPVTSSTADVFP-ATTGAVSTPVITSTELNT 3973

Query: 1171 PAPTSAPTSQQPEPVLGLGSVEQPHEVPSVLGTPLLQP--PENLAKG---------QPST 1219
            P+ +S+ T+          +       P    T    P  P   ++G           ST
Sbjct: 3974 PSTSSSSTTTSFSTTKEFTTPAMTTAAPLTYVTMSTAPSTPRTTSRGCTTSASTLSATST 4033

Query: 1220 P------VDRPLGP--DPSAPGTLAGAALPPLEPPA 1247
            P        RP+ P  + S P T+    +PP  PPA
Sbjct: 4034 PHTSTSVTTRPVTPSSESSRPSTITSHTIPPTFPPA 4069



 Score = 81.6 bits (200), Expect = 5e-15
 Identities = 192/878 (21%), Positives = 296/878 (33%), Gaps = 120/878 (13%)

Query: 558  CPDSPQNLKEEGGLDLPSGRKPVAAATIVPRQAKEDLTLPQDSAMTPPLPLQDTDLSSAP 617
            C  +P+    E  +   S    V++  + P +++       DS    P   +DT  SS  
Sbjct: 85   CSTNPEMTSIESSVT--SDTPGVSSTRMTPTESRTTSESTSDSTTLFPSSTEDT--SSPT 140

Query: 618  KPVAAATIVSQQAEEGLTLPQDSVMTPPLPLQDTELSSAPK-PVAAATLVSQQAEEGLTL 676
             P      +S  +EE ++     V T PLP  +   S   K  ++     S QA    T 
Sbjct: 141  TPEGTDVPMSTPSEESISSTMAFVSTAPLPSFEAYTSLTYKVDMSTPLTTSTQASSSPTT 200

Query: 677  PQDSAMTPPLPLQDTDLSSAPKPVAAATLVSQQAEEGLTLPQDSAMTPPLPLQDTDLSSA 736
            P+ +     +P       S P     A+ +   + E +TL     +T P+ +      S 
Sbjct: 201  PESTT----IPKSTNSEGSTPLTSMPASTMKVASSEAITL-----LTTPVEI------ST 245

Query: 737  PKPVAAATLVSQQAEEGLTLPQDSAMTPPLPLQDTDLSSAPKPVAAATIVSQQAEEGLTL 796
            P  ++A    S    EG +L   +      PL          P++   +VS +A    TL
Sbjct: 246  PVTISAQASSSPTTAEGPSLSNSAPSGGSTPL-------TRMPLSVMLVVSSEAS---TL 295

Query: 797  PQDSAMTPPLPLQDTDLSSAPKPVAAATIVSQQAEEGLTLPQDSAMTPPLPLQDTDLSS- 855
                A T    +  T+ SS+P      +I +    EG T P  S     +P+  +++S+ 
Sbjct: 296  STTPAATNIPVITSTEASSSPTTAEGTSIPTSTYTEGST-PLTSTPASTMPVATSEMSTL 354

Query: 856  APKPVAAATPVSQQAEEG---LTLPQDSAMTPPLPLQDTDLSSAPKPVAAATPVSQQAEE 912
            +  PV  +T V+   E      T    S +T  L    T L++   PV+     S +A  
Sbjct: 355  SITPVDTSTLVTTSTEPSSLPTTAEATSMLTSTLSEGSTPLTN--MPVSTILVASSEAST 412

Query: 913  GLTLPQDS---------AMTAPLPLQDTG-----PTSGPEPLA---VATPQTLQAEAGCA 955
              T+P DS         A ++P   +DT      P+ G  PL    V+T     +EA   
Sbjct: 413  TSTIPVDSKTFVTTASEASSSPTTAEDTSIATSTPSEGSTPLTSMPVSTTPVASSEASNL 472

Query: 956  PGTEPVATMAQQEVGEALGPRPAPEEKNAALPTVPE--------------PAALDQVQQD 1001
              T PV +  Q          P   E N+   + P               P A  +    
Sbjct: 473  -STTPVDSKTQVTTSTEASSSPPTAEVNSMPTSTPSEGSTPLTSMSVSTMPVASSEASTL 531

Query: 1002 DPQPAAEAGTPWAAQEDADSTLGMEALSLPEPASGAGEEIAEALSRPGREACLEARAHTG 1061
               P   +     + E + S+   E  S+P      G      +    R   + + A T 
Sbjct: 532  STTPVDTSTPVTTSSEASSSSTTPEGTSIPTSTPSEGSTPLTNMPVSTR-LVVSSEASTT 590

Query: 1062 DGAKPDS-----PQKETLEVENQQEGGLKPLA--QEHGPR-SALGGAREVPDAPPAACPE 1113
                 DS        E        EG   P +   E G   +++  +  +  +  A+   
Sbjct: 591  STTPADSNTFVTTSSEASSSSTTAEGTSMPTSTYSERGTTITSMSVSTTLVASSEASTLS 650

Query: 1114 VSQARLLSP-AREERGLSGKSTPEPT-LPSAVATEAS--LDSCPESSVGAVSSLDRGCPD 1169
             +     +P        S  +T E T +P++  TE S  L S P ++    SS       
Sbjct: 651  TTPVDSNTPVTTSTEATSSSTTAEGTSMPTSTYTEGSTPLTSMPVNTTLVASSEASTLST 710

Query: 1170 APAPTSAPTSQQPE----PVLGLGSVEQPHEVPSVLGTPLLQPPEN---LAKGQPSTPVD 1222
             P  TS P +   E    P    G+   P   PS   TPL   P +   L   + ST   
Sbjct: 711  TPVDTSTPVTTSTEASSSPTTADGA-SMPTSTPSEGSTPLTSMPVSKTLLTSSEASTLST 769

Query: 1223 RPLGPD---------PSAPGTLAGAALPPLEPP--APCLCQDP--------QEDSVEDEE 1263
             PL              +P T  G ++P   P   +P L   P         E S     
Sbjct: 770  TPLDTSTHITTSTEASCSPTTTEGTSMPISTPSEGSPLLTSIPVSITPVTSPEASTLSTT 829

Query: 1264 PPGSLGLPPPQAGVQPAAAAVSGTTQPLGTGPRVSLSPHSPLLSPKVASMDAKDLALQIL 1323
            P  S         V  +     GT+ P  T         +PL S  V++      A+  L
Sbjct: 830  PVDSNSPVTTSTEVSSSPTPAEGTSMPTST----YSEGRTPLTSMPVSTTLVATSAISTL 885

Query: 1324 --PPCQVPPP-----SGPQSPAGPQGLSAPEQQEDEDS 1354
               P     P         SP   +G S P     E S
Sbjct: 886  STTPVDTSTPVTNSTEARSSPTTSEGTSMPTSTPGEGS 923



 Score = 46.6 bits (109), Expect = 2e-04
 Identities = 88/411 (21%), Positives = 134/411 (32%), Gaps = 75/411 (18%)

Query: 479  STATVTPHTLQVAPGLQVEVATRVTPQAGEEETDSTAGQESAAMAMPQPSQEG------- 531
            ST  VT       P +     +     A E  +  T  + +  M M   S+         
Sbjct: 3761 STTPVTRFPESSTPSIPSVYTSMSMTTASEGSSSPTTLEGTTTMPMSTTSERSTLLTTVL 3820

Query: 532  ISEILGQESVTAEKLPTPQEETSLTLCPDSPQNLKEEGGLDLPSGRKPVAAATIVPRQAK 591
            IS I       A  L TP  +TS  L   +     + G   +P+    +  +    R   
Sbjct: 3821 ISPISVMSPSEASTLSTPPGDTSTPLLTST-----KAGSFSIPAEVTTIRISITSERSTP 3875

Query: 592  -----EDLTLPQDS-----AMTPPLPLQ-----DTDLSSAPKPVAAATIVSQQAEEGLTL 636
                    TLP        A TPPL         TD +S P    A TI      EG T 
Sbjct: 3876 LTTLLVSTTLPTSFPGASIASTPPLDTSTTFTPSTDTASTPTIPVATTISVSVITEGST- 3934

Query: 637  PQDSVMTPPLPLQDTELSSAPKPVAAATLVSQQAEEGLTLPQDSAMTPPLPLQDTDLSSA 696
            P  ++  P  P+  +     P    A +                  TP +    T+L++ 
Sbjct: 3935 PGTTIFIPSTPVTSSTADVFPATTGAVS------------------TPVIT--STELNT- 3973

Query: 697  PKPVAAATLVSQQAEEGLTLPQDSAMTPPLPLQDTDLSSAP---KPVAAATLVSQQAEEG 753
            P   +++T  S    +  T P   AMT   PL    +S+AP   +  +     S      
Sbjct: 3974 PSTSSSSTTTSFSTTKEFTTP---AMTTAAPLTYVTMSTAPSTPRTTSRGCTTSASTLSA 4030

Query: 754  LTLPQDSAMTPPLPLQDTDLSSAPKPVAAATIVSQQAEEGLTLPQDSAMTPPL------- 806
             + P  S      P+  +  SS P  + + TI         T P   + TPP        
Sbjct: 4031 TSTPHTSTSVTTRPVTPSSESSRPSTITSHTIPP-------TFPPAHSSTPPTTSASSTT 4083

Query: 807  --PLQDTDLSSAPKP----VAAATIVSQQAEEGLTLPQDSAMTPPLPLQDT 851
              P   T +++  KP     +  T+ +       T+  +   TP +P   T
Sbjct: 4084 VNPEAVTTMTTRTKPSTRTTSFPTVTTTAVPTNTTIKSNPTSTPTVPRTTT 4134


>gi|239751637 PREDICTED: hypothetical protein FLJ22184 [Homo sapiens]
          Length = 1124

 Score = 98.6 bits (244), Expect = 4e-20
 Identities = 207/776 (26%), Positives = 266/776 (34%), Gaps = 122/776 (15%)

Query: 680  SAMTPPLPLQDTDLS-SAPKPVAAATLVSQQAEEGLTLPQDSAMTPPLPLQDTDLSSAPK 738
            S  T P PL    L  SA + VA            L+       + P P         P 
Sbjct: 121  SGTTRPGPLGQKGLRISAEETVARGKATEAPKRSALSAGARRDTSGPTP-------GTPS 173

Query: 739  PVAAATLVSQQAEEGLTLPQDSAMT-PPLPLQDTDLSSA-------PKPVAAATIVSQQA 790
            P  A    +   E GL  P  SA   PP       +SSA       P P A        A
Sbjct: 174  PAMARRSRAAGTEVGLPRPAPSARPRPPTEGPRKSVSSASEHSTTEPSPAARRR---PSA 230

Query: 791  EEGLTLPQD---SAMTPPLPLQDTDLSSAPKPVAAATIVSQQAEEGLTLPQDSAMTPPL- 846
              GL  P     S+   PL        SA     A    SQ   +GL   +   +TPP  
Sbjct: 231  GGGLQRPASRSLSSSATPLSSPARSGPSARGTPRAPAHPSQPKPKGLQALRPPQVTPPRK 290

Query: 847  -------PLQDTDLSS----------APKPVAAATPVSQQAEEGLTLPQDSAMTPPLPLQ 889
                   PL  + L++           P P  AATP+        TLP    +  PLPL 
Sbjct: 291  DAAPALGPLSSSPLATPSPSGTKARPVPPPDNAATPLPA------TLPPSPPLATPLPLA 344

Query: 890  DTDLSSAPK----PVAAATPVSQQAEEGLTLPQDSAMTAPLPLQDTGPTSGPEPLAVATP 945
                S+ P     P   ATP SQ A   +T P    M AP  LQ   P   P  L   T 
Sbjct: 345  PPSPSAPPSLQTLPSPPATPPSQ-APPSMTTPP---MQAPPSLQTIPPIQVPHSL---TS 397

Query: 946  QTLQAEAGCAPGTEPVATMAQQEVGEALGPRPAPEEKNAALPTVPEPAALDQVQQDDPQP 1005
             +LQA         P+A  + Q    +LG  P  +  ++ L   P      Q Q     P
Sbjct: 398  PSLQAPPS------PLALSSLQAT-TSLGS-PTLQATHSFLTMSPR-----QTQASLTSP 444

Query: 1006 AAEAGTPWAAQEDADSTLGMEALSLPE--PASGAGEEIAEALSRPGREACLEARAHTGDG 1063
            +  A TP       DS      LSLP   P   +       LS P     L+A +     
Sbjct: 445  SRPASTP------PDSPPLQAPLSLPASPPLQTSLSPAVSPLSSPLTIHPLQALSSLASH 498

Query: 1064 AKPDSPQKETLEVENQQEGGLKPLAQEHGPRSALGGARE-VPD---------APPAACPE 1113
            + P +P    +    + +  L P + +  P S      E +P          + P   P 
Sbjct: 499  S-PQAPLSSLIMPPLETQSSLAPPSLQTPPASLTTPPLENLPSLAPPPLQTASAPLTTPH 557

Query: 1114 VSQARLLSPAREERGLSGKSTPEPTLPSAVATEASLDSCPESSVGAVSSLDRGCPDAP-A 1172
            +      +P   +   S  +TP P  PS++AT       P++     S   +G P  P +
Sbjct: 558  LETPPCPAPCPLQAPPSPLTTPPPETPSSIATPP-----PQAPPALASPPLQGLPSPPLS 612

Query: 1173 PTSAPTSQQPEPVLGLGSVEQPHEVP-----SVLGTPLLQPPENLAKGQPSTPVDRPLGP 1227
            P + P  Q P P L L  ++ P   P     S L TP  Q P  LA      P   P  P
Sbjct: 613  PLATPPPQAP-PXLALPPLQAPPSPPASPPLSPLATPSPQAPNALAVHLLQAPFSPPPSP 671

Query: 1228 DPSAPGTLAGAALPPLEPPAPCLCQDPQEDSVEDEEPPGSL-GLPPPQAGVQPAAAAVSG 1286
               AP +      PP  PP       P +       PP  +   PP    + P+A     
Sbjct: 672  PVQAPFS------PPASPPVSPSATPPSQAPPSLAAPPLQVPPSPPASPPMSPSATPPPQ 725

Query: 1287 TTQPLGTGP-RVSLS-PHSPLLSPKVASMDAKDLALQILPPCQV---PPPSGPQSPAGPQ 1341
               PL   P +V  S P SP +SP  A+   +   L   PP QV   PP S P SP    
Sbjct: 726  APPPLAAPPLQVPPSPPASPPMSPS-ATPPPRVPPLLAAPPLQVPPSPPASLPMSPLAKP 784

Query: 1342 GLSAPEQQEDEDSLEEDSPRALGSGQHSDSHGESSAELDEQDILAPQTVQCPAQAP 1397
               AP            SP A   GQ   S    SA L    +  P     P QAP
Sbjct: 785  PPQAPPALATPPLQALPSPPASFPGQAPFS---PSASLPMSPLATP-----PPQAP 832



 Score = 94.0 bits (232), Expect = 1e-18
 Identities = 247/1012 (24%), Positives = 345/1012 (34%), Gaps = 181/1012 (17%)

Query: 498  VATRVTPQAGEEETDSTAGQESAAMAMP-QPSQEGISEILGQESVTAEKLPTPQEETSLT 556
            +++  TP +    +  +A     A A P QP  +G+      +++   ++  P+++ +  
Sbjct: 242  LSSSATPLSSPARSGPSARGTPRAPAHPSQPKPKGL------QALRPPQVTPPRKDAAPA 295

Query: 557  LCPDSPQNLKEEGGLDLPSGRK------PVAAATIVPRQAKEDLTLPQDSAMTPPLPLQD 610
            L P S   L        PSG K      P  AAT +P       TLP    +  PLPL  
Sbjct: 296  LGPLSSSPLATPS----PSGTKARPVPPPDNAATPLPA------TLPPSPPLATPLPLAP 345

Query: 611  TDLSSAPKPVAAATIVSQQAEEGLTLPQDSVMTPPLPLQDTELSSAPKPVAAATLVSQQA 670
               S+ P   +  T+ S  A      P  S+ TPP+            P +  T+   Q 
Sbjct: 346  PSPSAPP---SLQTLPSPPATPPSQAPP-SMTTPPMQA----------PPSLQTIPPIQV 391

Query: 671  EEGLTLPQDSAMTPPLPLQDTDL---SSAPKPVAAAT-----LVSQQAEEGLTLPQDSAM 722
               LT P  S   PP PL  + L   +S   P   AT     +  +Q +  LT P   A 
Sbjct: 392  PHSLTSP--SLQAPPSPLALSSLQATTSLGSPTLQATHSFLTMSPRQTQASLTSPSRPAS 449

Query: 723  TPPLPLQDTDLSSAPKPVAAATLVSQQAEEGLTLPQDSAMTPPL---PLQDTDLSSAPKP 779
            TPP          +P   A  +L +    +    P  S ++ PL   PLQ     ++  P
Sbjct: 450  TPP---------DSPPLQAPLSLPASPPLQTSLSPAVSPLSSPLTIHPLQALSSLASHSP 500

Query: 780  VAA-ATIVSQQAEEGLTLPQDSAMTPPLPLQDTDLSSAPKPVAAATIVSQQAEEGLTLPQ 838
             A  ++++    E   +L   S  TPP  L    L + P   + A    Q A   LT P 
Sbjct: 501  QAPLSSLIMPPLETQSSLAPPSLQTPPASLTTPPLENLP---SLAPPPLQTASAPLTTPH 557

Query: 839  DSAMTPPLPLQDTDLSSAPKPVAAATPVSQQAEEGLTLPQDSAMTPPLPLQDTDLSSAPK 898
                TPP P     L + P P+    P   +    +  P   A   P  L    L   P 
Sbjct: 558  --LETPPCPAP-CPLQAPPSPLTTPPP---ETPSSIATPPPQA---PPALASPPLQGLPS 608

Query: 899  PVAA--ATPVSQQAEEGLTLPQDSAMTAPLPLQDTGPTSGPEPLAVATPQTLQAEAGCAP 956
            P  +  ATP   QA   L LP   A  +P       P + P P A   P  L      AP
Sbjct: 609  PPLSPLATP-PPQAPPXLALPPLQAPPSPPASPPLSPLATPSPQA---PNALAVHLLQAP 664

Query: 957  GTEPVATMAQQEVGEALGPRPAPEEKNAALPTVPEPA-ALDQVQQDDPQPAAEAGTPWAA 1015
             + P +   Q        P  +P   +A  P+   P+ A   +Q     PA+   +P A 
Sbjct: 665  FSPPPSPPVQAPFSPPASPPVSP---SATPPSQAPPSLAAPPLQVPPSPPASPPMSPSAT 721

Query: 1016 QE-DADSTLGMEALSLPEPASGAGEEIAEALSRPGREACLEARAHTGDGAKPDSPQKETL 1074
                A   L    L +P P+  A   ++ + + P R   L A       A P       L
Sbjct: 722  PPPQAPPPLAAPPLQVP-PSPPASPPMSPSATPPPRVPPLLA-------APP-------L 766

Query: 1075 EVENQQEGGLKPLAQEHGPRSALGGAREVPDAPPAACPEVSQARLLSPAREERG------ 1128
            +V       L        P S L  A+  P APPA      QA L SP     G      
Sbjct: 767  QVPPSPPASL--------PMSPL--AKPPPQAPPALATPPLQA-LPSPPASFPGQAPFSP 815

Query: 1129 -----LSGKSTPEPTLPSAVATEASLDSCPESSVGAVSSLDRGCPDAPAPTSAPTSQQPE 1183
                 +S  +TP P  P  +A  A L   P S     +S     P  P PT  P +    
Sbjct: 816  SASLPMSPLATPPPQAPPVLA--APLLQVPPSPP---ASPTLQAPRRP-PTPGPDTSVSG 869

Query: 1184 PVLGLGSVEQPHEVPSVLGTPLLQPPENLAKGQPSTPVDRPLGPDPSAPGTLAGAALPPL 1243
            P L L     P   PS   +  L  P+       +T     L    S P   A A+ PP 
Sbjct: 870  PRLTLALAPGPPPPPSRSPSSTLSGPDLAGHSSSATSTPEELRGYDSGPEGGAAASPPPD 929

Query: 1244 EPPAPCLCQDPQEDSVEDEEPPGSLGLPPPQAGVQPAAAAVSGTTQPLGTGPRVSLSPHS 1303
               A C                             PAA +  G   PL        +P +
Sbjct: 930  AELAAC----------------------------HPAAWS-RGPAPPLA----FRGAPGA 956

Query: 1304 PLLSPKVASMDAKDLALQILPPCQVPPPSGPQSPAGPQGLSAPEQQEDEDSLEEDSPRAL 1363
            PL  P      + D        C +    GP+S     G   P               A 
Sbjct: 957  PLPWPPATGPGSAD------GLCTIYETEGPESATPAPGALDPGPSPGTSG----GKAAA 1006

Query: 1364 GSGQHSDSHGESSAELDE-----------QDILAPQTVQCPAQAPAGGSEETIAKAKQSR 1412
            G+G  + S     A L E           Q +L+   +   A+  AGGS      A+   
Sbjct: 1007 GAGAGASSRSPKQARLGELPLGALQASVVQHLLSRTLLLAAAEGAAGGSGGGPGGAEGGG 1066

Query: 1413 SEKKARKAMSKLGLRQIQGVTRITIQKSKNILFVIA-KPDVFKSPASDTYVV 1463
                AR A+S   L +   +     +   +I  V +  PD   SP  D  VV
Sbjct: 1067 VTGGARAALSDAELGRWAELLSPLDESRASITSVTSFSPDDVASPQGDWTVV 1118



 Score = 93.2 bits (230), Expect = 2e-18
 Identities = 205/819 (25%), Positives = 273/819 (33%), Gaps = 135/819 (16%)

Query: 480  TATVTPHTLQVAP-GLQVEVATRVTPQAGEEETDSTAGQESAAMAMPQPSQEGISEILGQ 538
            T     H  Q  P GLQ     +VTP   ++   +     S+ +A P PS      +   
Sbjct: 262  TPRAPAHPSQPKPKGLQALRPPQVTPPR-KDAAPALGPLSSSPLATPSPSGTKARPVPPP 320

Query: 539  ESVT----AEKLPTPQEETSLTLCPDSP------QNL---------KEEGGLDLPSGRKP 579
            ++      A   P+P   T L L P SP      Q L         +    +  P  + P
Sbjct: 321  DNAATPLPATLPPSPPLATPLPLAPPSPSAPPSLQTLPSPPATPPSQAPPSMTTPPMQAP 380

Query: 580  VAAATIVPRQAKEDLTLPQDSAMTPPLPLQDTDL---SSAPKPVAAAT-----IVSQQAE 631
             +  TI P Q    LT P  S   PP PL  + L   +S   P   AT     +  +Q +
Sbjct: 381  PSLQTIPPIQVPHSLTSP--SLQAPPSPLALSSLQATTSLGSPTLQATHSFLTMSPRQTQ 438

Query: 632  EGLTLPQDSVMTPPLPLQDTELSSAPKPVAAATLVSQQAEEGLTLPQDSAMTPPL---PL 688
              LT P     TPP          +P   A  +L +    +    P  S ++ PL   PL
Sbjct: 439  ASLTSPSRPASTPP---------DSPPLQAPLSLPASPPLQTSLSPAVSPLSSPLTIHPL 489

Query: 689  QDTDLSSAPKPVAA-ATLVSQQAEEGLTLPQDSAMTPPLPLQDTDLSSAPKPVAAATLVS 747
            Q     ++  P A  ++L+    E   +L   S  TPP  L    L + P   + A    
Sbjct: 490  QALSSLASHSPQAPLSSLIMPPLETQSSLAPPSLQTPPASLTTPPLENLP---SLAPPPL 546

Query: 748  QQAEEGLTLPQDSAMTPPLPLQDTDLSSAPKPVAAATIVSQQAEEGLTLPQDSAMTPPLP 807
            Q A   LT P     TPP P     L + P P+   T    +    +  P   A   P  
Sbjct: 547  QTASAPLTTPH--LETPPCPAP-CPLQAPPSPL---TTPPPETPSSIATPPPQA---PPA 597

Query: 808  LQDTDLSSAPKP-VAAATIVSQQAEEGLTLPQDSAMTPPLPLQDTDLSSAPKPVAAATPV 866
            L    L   P P ++       QA   L LP   A  PP P     LS    P+A  +P 
Sbjct: 598  LASPPLQGLPSPPLSPLATPPPQAPPXLALPPLQA--PPSPPASPPLS----PLATPSPQ 651

Query: 867  SQQAEEGLTLPQDSAMTPPLPLQDTDLSSAPKPVAAATPVSQQAEEGLTLPQDSAMTAPL 926
            +  A     L    +  P  P+Q      A  PV+ +     QA   L  P      +P 
Sbjct: 652  APNALAVHLLQAPFSPPPSPPVQAPFSPPASPPVSPSATPPSQAPPSLAAPPLQVPPSPP 711

Query: 927  PLQDTGPTSGPEPLA----VATPQTLQAEAGCAPGTEPVATMAQQEVG-EALGPRPAPEE 981
                  P++ P P A     A P  +      +P   P AT   +     A  P   P  
Sbjct: 712  ASPPMSPSATPPPQAPPPLAAPPLQVPPSPPASPPMSPSATPPPRVPPLLAAPPLQVPPS 771

Query: 982  KNAALP----TVPEPAALDQVQQDDPQ--PAAEAGTPWAAQEDADSTLGMEALSLPEPAS 1035
              A+LP      P P A   +     Q  P+  A  P  A     ++L M  L+ P P  
Sbjct: 772  PPASLPMSPLAKPPPQAPPALATPPLQALPSPPASFPGQAPFSPSASLPMSPLATPPP-- 829

Query: 1036 GAGEEIAEALSRPGREACLEARAHTGDGAKPDSPQKETLEVENQQEGGLKPLAQEHGPRS 1095
                +    L+ P  +              P  P   TL+   +      P     GPR 
Sbjct: 830  ----QAPPVLAAPLLQ------------VPPSPPASPTLQAPRRPPTP-GPDTSVSGPRL 872

Query: 1096 ALGGAREVPDAPPAACPEVSQARLLSPAREERGLSGKSTPEPTLPSAVATEASLDSCPES 1155
             L  A   P  PP+  P    + L  P       S  STPE             DS PE 
Sbjct: 873  TLALA-PGPPPPPSRSP---SSTLSGPDLAGHSSSATSTPEEL--------RGYDSGPEG 920

Query: 1156 SVGAVSSLDRGCPDAPAPTSAPT--SQQPEPVLGLGSVEQPHEVPSVLGTPLLQPP---E 1210
               A        PDA      P   S+ P P L               G PL  PP    
Sbjct: 921  GAAASPP-----PDAELAACHPAAWSRGPAPPLAFRGAP---------GAPLPWPPATGP 966

Query: 1211 NLAKG----------QPSTPVDRPLGPDPSAPGTLAGAA 1239
              A G          + +TP    L P PS PGT  G A
Sbjct: 967  GSADGLCTIYETEGPESATPAPGALDPGPS-PGTSGGKA 1004



 Score = 61.2 bits (147), Expect = 7e-09
 Identities = 135/546 (24%), Positives = 178/546 (32%), Gaps = 55/546 (10%)

Query: 949  QAEAGCAPGTEPVATMAQQEVGEALGPRPAPEEKNAALPTVPEPAALDQVQQDDPQPAAE 1008
            +A+AG A  T                PRP P    AAL  +    A+ +    +      
Sbjct: 7    KAKAGAAARTPAARAPGLLTPRPPGSPRPPPPVTPAALRVLGAAGAVGRKPLAERAGGIG 66

Query: 1009 AGT-----PWAAQEDADSTLGMEALSLPEPASGAGEEIAEALSRPGREACLEARAHTGDG 1063
              T     P A    +  T      S P PASG GE    A +          RA     
Sbjct: 67   GATIPESAPRAGPTRSAGTSSRNPASRP-PASGRGERAPPAKNTSPGPVSSPGRA--SGT 123

Query: 1064 AKPDSPQKETLEVENQQEGGLKPLAQEHGPRSALG-GAREVPDAPPAACPEVSQARLLSP 1122
             +P    ++ L + + +E   +  A E   RSAL  GAR     P    P  + AR    
Sbjct: 124  TRPGPLGQKGLRI-SAEETVARGKATEAPKRSALSAGARRDTSGPTPGTPSPAMARRSRA 182

Query: 1123 AREERGLSGKSTPEPTLPSAVATEASLDSCPESSVGAVSSLDRGCPDA------PA---- 1172
            A  E GL   +      P       S+ S  E S    S   R  P A      PA    
Sbjct: 183  AGTEVGLPRPAPSARPRPPTEGPRKSVSSASEHSTTEPSPAARRRPSAGGGLQRPASRSL 242

Query: 1173 -----PTSAPTSQQPEPVLGLGSVEQPHEVPSVLGTPLLQPPENLAKGQPSTPVDRPLGP 1227
                 P S+P    P    G          P   G   L+PP+     + + P   PL  
Sbjct: 243  SSSATPLSSPARSGPS-ARGTPRAPAHPSQPKPKGLQALRPPQVTPPRKDAAPALGPLSS 301

Query: 1228 DPSAPGTLAGAALPPLEPPAPCLCQDPQEDSVEDEEPPGSLGLPPPQAGVQPAA-AAVSG 1286
             P A  + +G    P+ PP       P   +     PP  L  P P A   P+A  ++  
Sbjct: 302  SPLATPSPSGTKARPVPPPDNAATPLP---ATLPPSPP--LATPLPLAPPSPSAPPSLQT 356

Query: 1287 TTQPLGTGPRVSLSPHSPLLSPKVASMDAKDLALQILPPCQVP---PPSGPQSPAGPQGL 1343
               P  T P  S +P S    P  A       +LQ +PP QVP        Q+P  P  L
Sbjct: 357  LPSPPATPP--SQAPPSMTTPPMQAPP-----SLQTIPPIQVPHSLTSPSLQAPPSPLAL 409

Query: 1344 S---------APEQQEDEDSLEEDSPRALGSGQHSDSHGESSAELDEQDILAPQTVQCPA 1394
            S         +P  Q     L   SPR   +   S S   +S   D   + AP  +  PA
Sbjct: 410  SSLQATTSLGSPTLQATHSFLTM-SPRQTQASLTSPSR-PASTPPDSPPLQAP--LSLPA 465

Query: 1395 QAPAGGSEETIAKAKQSRSEKKARKAMSKLGLRQIQGVTRITIQKSKNILFVIAKPDVFK 1454
              P   S         S       +A+S L     Q      I         +A P +  
Sbjct: 466  SPPLQTSLSPAVSPLSSPLTIHPLQALSSLASHSPQAPLSSLIMPPLETQSSLAPPSLQT 525

Query: 1455 SPASDT 1460
             PAS T
Sbjct: 526  PPASLT 531



 Score = 37.4 bits (85), Expect = 0.11
 Identities = 65/279 (23%), Positives = 87/279 (31%), Gaps = 45/279 (16%)

Query: 80  PSAWADPGEGGPSPMLLPEGLSSQALSTEAPLPATLEPRIVMGEETCQALLSPRAARTAL 139
           PS    P +   +P+  P  L +       PL A   P      ET  ++ +P       
Sbjct: 539 PSLAPPPLQTASAPLTTPH-LETPPCPAPCPLQAPPSPLTTPPPETPSSIATP------- 590

Query: 140 RDQEGGHASPDPPPELCSQGDLSVPSPP------PDPDS--------FFTPPSTPTKTTY 185
                    P  PP L S     +PSPP      P P +           PPS P     
Sbjct: 591 --------PPQAPPALASPPLQGLPSPPLSPLATPPPQAPPXLALPPLQAPPSPPASP-- 640

Query: 186 ALLPACGPHGDARDSEAELRDELLDSPPASPSGSYITADGDSWASSPSCSLSLLAPAEGL 245
            L P   P   A ++ A    +   SPP SP      +   S   SPS +    AP    
Sbjct: 641 PLSPLATPSPQAPNALAVHLLQAPFSPPPSPPVQAPFSPPASPPVSPSATPPSQAPPSLA 700

Query: 246 DFPSGWGLSPQGSMVDERELHPAGTPEPPSSESSLSADSSSSWGQEGHFFDLDFLANDPM 305
             P     SP  S        P     PP +   L    S               A+ PM
Sbjct: 701 APPLQVPPSPPASPPMSPSATPPPQAPPPLAAPPLQVPPSPP-------------ASPPM 747

Query: 306 IPAALLPFQGSLIFQVEAVEVTPLSPEEEEEEAVADPDP 344
            P+A  P +   +     ++V P  P       +A P P
Sbjct: 748 SPSATPPPRVPPLLAAPPLQVPPSPPASLPMSPLAKPPP 786



 Score = 33.9 bits (76), Expect = 1.3
 Identities = 76/309 (24%), Positives = 105/309 (33%), Gaps = 72/309 (23%)

Query: 13  PEADRPGPRTDLSCDAAAATT----------ILGGDRREPCA------LTP-------GP 49
           P     GPR  +S  +  +TT            GG  + P +       TP       GP
Sbjct: 198 PRPPTEGPRKSVSSASEHSTTEPSPAARRRPSAGGGLQRPASRSLSSSATPLSSPARSGP 257

Query: 50  SHLALTFLPSKPGARPQPEGASWDAGPGGAPSAWADPGEGGP---SPMLLPEGLSSQAL- 105
           S       P+ P ++P+P+G      P   P         GP   SP+  P    ++A  
Sbjct: 258 SARGTPRAPAHP-SQPKPKGLQALRPPQVTPPRKDAAPALGPLSSSPLATPSPSGTKARP 316

Query: 106 -----STEAPLPATLEPRIVMGEETCQALLSPRAARTALRDQEGGHASPDPPPELCSQGD 160
                +   PLPATL P   +   T   L  P               SP  PP L  Q  
Sbjct: 317 VPPPDNAATPLPATLPPSPPLA--TPLPLAPP---------------SPSAPPSL--QTL 357

Query: 161 LSVPSPPPD--PDSFFTPPSTPTKTTYALLPACGPHGDARDSEAELRDELLDSPPASPSG 218
            S P+ PP   P S  TPP     +   + P   PH         L    L +PP+  + 
Sbjct: 358 PSPPATPPSQAPPSMTTPPMQAPPSLQTIPPIQVPH--------SLTSPSLQAPPSPLAL 409

Query: 219 SYITADGDSWASSPSCSLSLLAPA-----EGLDFPSGWGLSPQGSMVDERELH-PAGTPE 272
           S + A     + +   + S L  +       L  PS     P  +  D   L  P   P 
Sbjct: 410 SSLQATTSLGSPTLQATHSFLTMSPRQTQASLTSPS----RPASTPPDSPPLQAPLSLPA 465

Query: 273 PPSSESSLS 281
            P  ++SLS
Sbjct: 466 SPPLQTSLS 474


>gi|132626688 mediator of DNA-damage checkpoint 1 [Homo sapiens]
          Length = 2089

 Score = 98.2 bits (243), Expect = 5e-20
 Identities = 235/1049 (22%), Positives = 366/1049 (34%), Gaps = 140/1049 (13%)

Query: 401  DERLYSG-EPHAQATLLQDSVQKTEEESGGGAKGLQAQDGTVSWAVEAAPQTSDRGAYLS 459
            +E L  G +   Q  LL    Q+ E +  G +   +    ++   +E + +  ++     
Sbjct: 849  EEELTKGKQDREQKQLLARDTQRQESDKNGESASPERDRESLKVEIETSEEIQEKQV--- 905

Query: 460  QRQELISEVTEEGLALGQESTATVTPHTLQVAPGLQVEVATRVTPQAGEEETDSTAGQES 519
            Q+Q L S+  E  +     +         +  P + +E  T    Q GE E  S   +  
Sbjct: 906  QKQTLPSKAFEREVERPVANRECDPAELEEKVPKVILERDT----QRGEPEGGSQDQKGQ 961

Query: 520  AAMAMPQPSQEGISEILGQESVTAEKLPTPQ-EETSLTLCPDSPQNLKEEGGLD--LPSG 576
            A+   P+P   G  ++ G  S      P P   ++     P SP+   ++G L+  +P  
Sbjct: 962  ASSPTPEPGV-GAGDLPGPTSA-----PVPSGSQSGGRGSPVSPRR-HQKGLLNCKMPPA 1014

Query: 577  RKP--VAAATIVPR--QAKEDLTLPQDSAMTPPLPLQDTDLSS----APKPVAAATIVSQ 628
             K   + AA  V R  Q   D  LP      P  P +  +  S    AP P+ +  + S 
Sbjct: 1015 EKASRIRAAEKVSRGDQESPDACLPPTVPEAPAPPQKPLNSQSQKHLAPPPLLSPLLPSI 1074

Query: 629  QAEEGLTLPQDSVMTPPLPLQDTELSSAPKPVAAATLVSQQAEEGLTLPQDSAMTPPLPL 688
            +     T    S   P  PL        PKP     + ++++      P  SA   P P 
Sbjct: 1075 KPTVRKTRQDGSQEAPEAPLSSELEPFHPKP----KIRTRKSSRMTPFPATSAAPEPHPS 1130

Query: 689  QDTDLSSAPKPVAAATLVSQQAEEGLTLPQDSAMTPP--LPLQDTDLSSAPKPVAAATLV 746
              T     PKP + AT  S+     +  P+    T P   P   TD     +P +  T  
Sbjct: 1131 TSTAQPVTPKPTSQATR-SRTNRSSVKTPEPVVPTAPELQPSTSTDQPVTSEPTSQVTR- 1188

Query: 747  SQQAEEGLTLPQDSAMTPP--LPLQDTDLSSAPKPVAAATIVSQQAEEGLTLPQDSAMTP 804
             +++   +  P+    T     P   TD     +P + AT   ++    +  P+    T 
Sbjct: 1189 GRKSRSSVKTPETVVPTALELQPSTSTDRPVTSEPTSQATR-GRKNRSSVKTPEPVVPTA 1247

Query: 805  P--LPLQDTDLSSAPKPVAAATIVSQQAEEGLTLPQDSAMTPP--LPLQDTDLSSAPKPV 860
            P   P   TD     +P   AT   ++    +  P+    T P   P   TD    PKP 
Sbjct: 1248 PELQPSTSTDQPVTSEPTYQATR-GRKNRSSVKTPEPVVPTAPELRPSTSTDRPVTPKPT 1306

Query: 861  AAATPVSQQAEEGLTLPQDSAMTPPLPLQ---DTDLSSAPKPVAAATPVSQQAEEGLTLP 917
            +  T  S+     +  P+    T P  LQ    TD    PKP +  T  S+     +  P
Sbjct: 1307 SRTTR-SRTNMSSVKTPETVVPTAP-ELQISTSTDQPVTPKPTSRTTR-SRTNMSSVKNP 1363

Query: 918  QDSAMTAPL--PLQDTGPTSGPEPLAVATPQTLQAEAGCAPGT---------------EP 960
            + +   AP   P   T     PEP + AT       +G  P T               +P
Sbjct: 1364 ESTVPIAPELPPSTSTEQPVTPEPTSRATRGRKNRSSGKTPETLVPTAPKLEPSTSTDQP 1423

Query: 961  VATMAQQEVGEALGPRPAPEEKNAALPTVPE---PAALDQVQQDDPQPAAEAGTPWAAQE 1017
            V      +       R + +     +PT PE     + DQ    +P   A  G    +  
Sbjct: 1424 VTPEPTSQATRGRTNRSSVKTPETVVPTAPELQPSTSTDQPVTPEPTSQATRGRTDRSSV 1483

Query: 1018 DADSTLGMEALSLPEPASGAGEEIAEALSRPGREACLEARAHTGDGAKPDSPQKETLEVE 1077
                T+   A  L   AS      +E  SR  R     +   T +   P +P+ +     
Sbjct: 1484 KTPETVVPTAPELQASASTDQPVTSEPTSRTTRGRKNRSSVKTPETVVPAAPELQPSTST 1543

Query: 1078 NQQEGGLKPLAQEHGPRSALGGARE---------VPDAPPAACPEVSQARLLSPAREERG 1128
            +Q      P+  E   R+  G             VP AP    P  S+ +L++P    R 
Sbjct: 1544 DQ------PVTPEPTSRATRGRTNRSSVKTPESIVPIAPELQ-PSTSRNQLVTPEPTSRA 1596

Query: 1129 L------SGKSTPEPTLPSAV----ATEASLDSCPESSVGAV------SSLDRGCPDAPA 1172
                   S   TPEP +P+A      T       P+ +  A       SS+    P  PA
Sbjct: 1597 TRCRTNRSSVKTPEPVVPTAPEPHPTTSTDQPVTPKLTSRATRRKTNRSSVKTPKPVEPA 1656

Query: 1173 PTS----APTSQQPEP-VLGLGSVEQPHEVPSVLGTPLLQPPENLAKGQPSTPVDRPLGP 1227
             +      PT Q   P  +  G   +     +V   P+   PE     Q     D+P+ P
Sbjct: 1657 ASDLEPFTPTDQSVTPEAIAQGGQSKTLRSSTVRAMPVPTTPEF----QSPVTTDQPISP 1712

Query: 1228 DPSA-------------PGTLAGA-----ALPPLEPPAPCLCQDPQEDSVEDEEPPGSLG 1269
            +P               PG+LA          PLEP +    ++ +  +V   E   ++ 
Sbjct: 1713 EPITQPSCIKRQRAAGNPGSLAAPIDHKPCSAPLEPKSQA-SRNQRWGAVRAAESLTAIP 1771

Query: 1270 LPP-PQAGVQPAAAAVSGTTQPLGTGPRVSLSPHSPLLSPKVASMDAKDLALQILPPCQV 1328
             P  PQ    P  A+     +P G       S  +P L PK +    + LA    PP Q 
Sbjct: 1772 EPASPQLLETPIHASQIQKVEPAGR------SRFTPELQPKASQSRKRSLATMDSPPHQK 1825

Query: 1329 PPPSGPQSPAGPQGLSAPEQQEDEDSLEE 1357
             P  G  S       +   ++E+ED+ E+
Sbjct: 1826 QPQRGEVSQK-----TVIIKEEEEDTAEK 1849



 Score = 73.6 bits (179), Expect = 1e-12
 Identities = 186/864 (21%), Positives = 296/864 (34%), Gaps = 102/864 (11%)

Query: 487  TLQVAPGLQVEVATRVTPQAG--EEETDSTAGQESAAMAMPQPSQEGISEILGQESVTAE 544
            T+    G+  E A RV P+ G  E ET+    +    +   +   +G  +   ++ +  +
Sbjct: 809  TVDKVMGIPKETAERVGPERGPLERETEKLLPERQTDVTGEEELTKGKQDREQKQLLARD 868

Query: 545  KLPTPQEETSLTLCPDSP-QNLKEEGGLDLPSGRKPVAAATIVPRQAKEDLTLPQDSAMT 603
                  ++   +  P+   ++LK E         K V   T+  +  + ++  P  +   
Sbjct: 869  TQRQESDKNGESASPERDRESLKVEIETSEEIQEKQVQKQTLPSKAFEREVERPVANREC 928

Query: 604  PPLPLQDTDLSSAPKPVAAATIVSQQAE-EGLTLPQDSVMTPPLPLQDTELSSAPKPVAA 662
             P  L++      PK +      +Q+ E EG +  Q    + P P         P P +A
Sbjct: 929  DPAELEE----KVPKVILERD--TQRGEPEGGSQDQKGQASSPTPEPGVGAGDLPGPTSA 982

Query: 663  ATLVSQQAEEGLTLPQDSAMTPPLPLQDTDLSSAPKP--VAAATLVSQQAEEG--LTLPQ 718
               V   ++ G      S       L +  +  A K   + AA  VS+  +E     LP 
Sbjct: 983  P--VPSGSQSGGRGSPVSPRRHQKGLLNCKMPPAEKASRIRAAEKVSRGDQESPDACLPP 1040

Query: 719  DSAMTPPLPLQDTDLSS----APKPVAAATLVSQQAEEGLTLPQDSAMTPPLPLQDTDLS 774
                 P  P +  +  S    AP P+ +  L S +     T    S   P  PL      
Sbjct: 1041 TVPEAPAPPQKPLNSQSQKHLAPPPLLSPLLPSIKPTVRKTRQDGSQEAPEAPLSSELEP 1100

Query: 775  SAPKPVAAATIVSQQAEEGLTLPQDSAMTPPLPLQDTDLSSAPKPVAAATIVSQQAEEGL 834
              PKP     I ++++      P  SA   P P   T     PKP + AT  S+     +
Sbjct: 1101 FHPKP----KIRTRKSSRMTPFPATSAAPEPHPSTSTAQPVTPKPTSQATR-SRTNRSSV 1155

Query: 835  TLPQDSAMTPP--LPLQDTDLSSAPKPVAAATPVSQQAEEGLTLPQDSAMTPP--LPLQD 890
              P+    T P   P   TD     +P +  T   +++   +  P+    T     P   
Sbjct: 1156 KTPEPVVPTAPELQPSTSTDQPVTSEPTSQVTR-GRKSRSSVKTPETVVPTALELQPSTS 1214

Query: 891  TDLSSAPKPVAAATPVSQQAEEGLTLPQDSAMTAPLPLQDTGPTSGPEPLAVATPQTLQA 950
            TD     +P + AT   ++    +  P+    TAP  LQ +  T  P    V +  T QA
Sbjct: 1215 TDRPVTSEPTSQATR-GRKNRSSVKTPEPVVPTAP-ELQPSTSTDQP----VTSEPTYQA 1268

Query: 951  EAG-----CAPGTEPVATMAQQ-----EVGEALGPRPAPEEKNA------------ALPT 988
              G          EPV   A +          + P+P      +             +PT
Sbjct: 1269 TRGRKNRSSVKTPEPVVPTAPELRPSTSTDRPVTPKPTSRTTRSRTNMSSVKTPETVVPT 1328

Query: 989  VPEPAALDQVQQD-DPQPAAE---AGTPWAAQEDADSTLGMEALSLPEPASGAGEEIAEA 1044
             PE        Q   P+P +    + T  ++ ++ +ST+ + A  LP   S       E 
Sbjct: 1329 APELQISTSTDQPVTPKPTSRTTRSRTNMSSVKNPESTVPI-APELPPSTSTEQPVTPEP 1387

Query: 1045 LSRPGREACLEARAHTGDGAKPDSPQKETLEVENQQEGGLKPLAQEHGPRSALGGAREVP 1104
             SR  R     +   T +   P +P+ E       Q    +P +Q    R+     +   
Sbjct: 1388 TSRATRGRKNRSSGKTPETLVPTAPKLEP-STSTDQPVTPEPTSQATRGRTNRSSVKTPE 1446

Query: 1105 DAPPAACPEVSQARLLSPAREERGLSGKSTPEPTLPSAVA-TEASLDSCPESSVGAVSSL 1163
               P A PE+  +                TPEPT  +    T+ S    PE+ V     L
Sbjct: 1447 TVVPTA-PELQPST---------STDQPVTPEPTSQATRGRTDRSSVKTPETVVPTAPEL 1496

Query: 1164 DRGCPDAPAPTSAPTSQQPEPVLGLGSVEQPHEVPSVLGTPLLQPPENLAKGQPSTPVDR 1223
                      TS PTS+         SV+ P  V  V   P LQP         ST  D+
Sbjct: 1497 QASASTDQPVTSEPTSRTTRGRKNRSSVKTPETV--VPAAPELQP---------STSTDQ 1545

Query: 1224 PLGPDPSAPGTLAGAALPPLEPP------APCLCQDPQEDSVEDEEPP----------GS 1267
            P+ P+P++  T        ++ P      AP L      + +   EP            S
Sbjct: 1546 PVTPEPTSRATRGRTNRSSVKTPESIVPIAPELQPSTSRNQLVTPEPTSRATRCRTNRSS 1605

Query: 1268 LGLPPPQAGVQPAAAAVSGTTQPL 1291
            +  P P     P     + T QP+
Sbjct: 1606 VKTPEPVVPTAPEPHPTTSTDQPV 1629



 Score = 47.0 bits (110), Expect = 1e-04
 Identities = 113/538 (21%), Positives = 181/538 (33%), Gaps = 87/538 (16%)

Query: 858  KPVAAATPVSQQAEEGLTLPQDSAMTPPLPLQDTDLSSAPKPVAAATPVSQQAE-EGLTL 916
            K V   T  S+  E  +  P  +    P  L++      PK +      +Q+ E EG + 
Sbjct: 903  KQVQKQTLPSKAFEREVERPVANRECDPAELEE----KVPKVILERD--TQRGEPEGGSQ 956

Query: 917  PQDSAMTAPLPLQDTGPTSGPEPLAVATPQTLQAEAGCAPGTEPVATMAQQEVGEALGPR 976
             Q    ++P P    G    P P +   P   Q+    +P    V+    Q+    L  +
Sbjct: 957  DQKGQASSPTPEPGVGAGDLPGPTSAPVPSGSQSGGRGSP----VSPRRHQK--GLLNCK 1010

Query: 977  PAPEEKNAALPTVPEPAALDQVQQDDPQPAAEAGTPWAAQEDADSTLGMEALSLPEPASG 1036
              P EK + +    + +  DQ   D   P      P   Q+  +S    + L+ P   S 
Sbjct: 1011 MPPAEKASRIRAAEKVSRGDQESPDACLPPTVPEAPAPPQKPLNSQ-SQKHLAPPPLLSP 1069

Query: 1037 AGEEIAEALSRPGREACLEARAHTGDGAKPDSPQKETLEVENQQEGGLKPLAQEHGPRSA 1096
                I   + +  ++   EA         P++P    LE          P  +    +S+
Sbjct: 1070 LLPSIKPTVRKTRQDGSQEA---------PEAPLSSELEP-------FHPKPKIRTRKSS 1113

Query: 1097 LGGAREVPDAPPAACPEVSQARLLSP------AREERGLSGKSTPEPTLPSAVATEASLD 1150
                     A P   P  S A+ ++P       R     S   TPEP +P+A   + S  
Sbjct: 1114 RMTPFPATSAAPEPHPSTSTAQPVTPKPTSQATRSRTNRSSVKTPEPVVPTAPELQPSTS 1173

Query: 1151 SCPESSVGAVSSLDRGCPDAPAPTSAPTSQQPEPVLGLGSVEQPHEV-PSVLGTPLLQPP 1209
            +                 D P  TS PTSQ         SV+ P  V P+ L        
Sbjct: 1174 T-----------------DQPV-TSEPTSQVTRGRKSRSSVKTPETVVPTALEL------ 1209

Query: 1210 ENLAKGQPSTPVDRPLGPDPSAPGT-----LAGAALP-PLEPPAPCLCQDPQEDSVEDEE 1263
                  QPST  DRP+  +P++  T      +    P P+ P AP L      D     E
Sbjct: 1210 ------QPSTSTDRPVTSEPTSQATRGRKNRSSVKTPEPVVPTAPELQPSTSTDQPVTSE 1263

Query: 1264 PP----------GSLGLPPPQAGVQPAAAAVSGTTQPLGTGPRV----SLSPHSPLLSPK 1309
            P            S+  P P     P     + T +P+   P      S +  S + +P+
Sbjct: 1264 PTYQATRGRKNRSSVKTPEPVVPTAPELRPSTSTDRPVTPKPTSRTTRSRTNMSSVKTPE 1323

Query: 1310 VASMDAKDLALQILPPCQVPPPSGPQSPAGPQGLSAPEQQEDEDSLEEDSPRALGSGQ 1367
                 A +L +       V P    ++      +S+ +  E    +  + P +  + Q
Sbjct: 1324 TVVPTAPELQISTSTDQPVTPKPTSRTTRSRTNMSSVKNPESTVPIAPELPPSTSTEQ 1381


>gi|189181724 proteoglycan 4 isoform D [Homo sapiens]
          Length = 1270

 Score = 94.7 bits (234), Expect = 6e-19
 Identities = 205/931 (22%), Positives = 322/931 (34%), Gaps = 135/931 (14%)

Query: 468  VTEEGLALGQESTATVTPHTL-----QVAPGLQVEVATRVTPQAG-------EEETDSTA 515
            V E G  L        TP T      +V+   ++  A  + P+          +ET  T 
Sbjct: 85   VDEAGSGLDNGDFKVTTPDTSTTQHNKVSTSPKITTAKPINPRPSLPPNSDTSKETSLTV 144

Query: 516  GQESAAMAMPQPSQEGISEILGQESVTAEKLPTPQEETSLT-LCPDSPQNLKEEGGLDLP 574
             +E+        +    +   G+E  T+ K     E+TS   L P S    K     +  
Sbjct: 145  NKETTVETKETTTTNKQTSTDGKEKTTSAKETQSIEKTSAKDLAPTSKVLAKPTPKAETT 204

Query: 575  SGRKPVAAATIVPRQAKEDLTLPQDSAMTPPLPLQDTDLSSAPK-PVAAATIVSQQAEEG 633
            +       A   P++     T P++ A T P     T + SAP  P   A   ++ A   
Sbjct: 205  TK----GPALTTPKEPTP--TTPKEPASTTPKEPTPTTIKSAPTTPKEPAPTTTKSAPTT 258

Query: 634  LTLPQDSVMTPPLPLQDTE----LSSAPKPVAAATLVSQQAEEGLTLPQDSAMTPPLPLQ 689
               P  +    P P    E     +  P P    +  +   E   T P+  A T P    
Sbjct: 259  PKEPAPTTTKEPAPTTPKEPAPTTTKEPAPTTTKSAPTTPKEPAPTTPKKPAPTTPKEPA 318

Query: 690  DTDLSSAPKPVAAATLVSQQAEEGLTLPQDSAMTPPL-PLQDTDLSSAPK-PVAAATLVS 747
             T     P P           E   T P++ A T P  P   T    AP  P   A   +
Sbjct: 319  PTT-PKEPTPTTPKEPAPTTKEPAPTTPKEPAPTAPKKPAPTTPKEPAPTTPKEPAPTTT 377

Query: 748  QQAEEGLTLPQDSAMTPPLPLQDTDLSSAPKPVAAATIVSQQA------EEGLTLPQDSA 801
            +  E   T P++ A T       T    AP    +A    ++       E   T P++ A
Sbjct: 378  K--EPSPTTPKEPAPTTTKSAPTTTKEPAPTTTKSAPTTPKEPSPTTTKEPAPTTPKEPA 435

Query: 802  -MTPPLPLQDTDLSSAP----KPVAAAT---IVSQQAEEGLTLPQDSAMTPPLPLQDTDL 853
              TP  P   T    AP    +P    T     +   E   T P+++A T P  L  T  
Sbjct: 436  PTTPKKPAPTTPKEPAPTTPKEPAPTTTKKPAPTTPKEPAPTTPKETAPTTPKKLTPT-- 493

Query: 854  SSAPKPVAAATPVSQQAEEGLTLPQDSA-MTPPLPLQDTDLSSAPKPVAAATPVSQQAEE 912
               P+ +A  TP     +   T P++ A  TP  P   T    AP    AA P +   E 
Sbjct: 494  --TPEKLAPTTP----EKPAPTTPEELAPTTPEEPTPTTPEEPAPTTPKAAAP-NTPKEP 546

Query: 913  GLTLPQDSAMTAPLPLQDTGPTSGPEPLAVATPQTLQAEAGCAPGT--EPVATMAQQEVG 970
              T P++ A T P   ++  PT+ P+  A  TP+      G AP T  EP  T  ++   
Sbjct: 547  APTTPKEPAPTTP---KEPAPTT-PKETAPTTPK------GTAPTTLKEPAPTTPKKPAP 596

Query: 971  EALGP------------RPAPEEKNAALPTVP-EPAALDQVQQDDPQPAAEAGT-PWAAQ 1016
            + L P            +PAP       PT P EPA        +P P    GT P   +
Sbjct: 597  KELAPTTTKEPTSTTCDKPAPTTPKGTAPTTPKEPA---PTTPKEPAPTTPKGTAPTTLK 653

Query: 1017 EDA--------------DSTLGMEALSLPEPASGAGEEIAEALSRPGREACLEARAHTGD 1062
            E A               +T G  + +  +PA    +E A    +       +  A T  
Sbjct: 654  EPAPTTPKKPAPKELAPTTTKGPTSTTSDKPAPTTPKETAPTTPKEPAPTTPKKPAPTTP 713

Query: 1063 GAKPDSPQ--------KETLEVENQQEGGLKPLAQEHGPRSALGGAREVPDAPPAACPEV 1114
               P +          KE   +    +     L+ E  P+ AL  + + P  P    P  
Sbjct: 714  ETPPPTTSEVSTPTTTKEPTTIHKSPDESTPELSAEPTPK-ALENSPKEPGVPTTKTPAA 772

Query: 1115 SQARLLSPARE---ERGLSGKSTPEPTLPSAVATEASLDSCPESSVGAVSSLDRGCPDAP 1171
            ++  + + A++   ER L  ++TPE T  +   T+ +  +  +++   +++         
Sbjct: 773  TKPEMTTTAKDKTTERDL--RTTPETTTAAPKMTKETATTTEKTTESKITA-------TT 823

Query: 1172 APTSAPTSQQPEP--VLGLGSVEQPHEV----PSVLGTPLLQPPENLAKGQPSTPVDRPL 1225
               ++ T+Q   P  +  L +     +V     ++  T ++  PE  AK +      +  
Sbjct: 824  TQVTSTTTQDTTPFKITTLKTTTLAPKVTTTKKTITTTEIMNKPEETAKPKDRATNSKAT 883

Query: 1226 GPDPSAPGTLAGAALPPLEPPAPCLCQDPQEDSVEDEEPPGSLGLPPPQAGVQPAAAAVS 1285
             P P           P   P  P   + P+  ++     P +   P       P     S
Sbjct: 884  TPKPQK---------PTKAPKKPTSTKKPK--TMPRVRKPKTTPTPRKMTSTMPELNPTS 932

Query: 1286 GTTQP-LGTGPRVSLSPHSPLLSPKVASMDA 1315
               +  L T  R + +P+S L+     S DA
Sbjct: 933  RIAEAMLQTTTRPNQTPNSKLVEVNPKSEDA 963


>gi|189181722 proteoglycan 4 isoform C [Homo sapiens]
          Length = 1311

 Score = 94.7 bits (234), Expect = 6e-19
 Identities = 205/931 (22%), Positives = 322/931 (34%), Gaps = 135/931 (14%)

Query: 468  VTEEGLALGQESTATVTPHTL-----QVAPGLQVEVATRVTPQAG-------EEETDSTA 515
            V E G  L        TP T      +V+   ++  A  + P+          +ET  T 
Sbjct: 126  VDEAGSGLDNGDFKVTTPDTSTTQHNKVSTSPKITTAKPINPRPSLPPNSDTSKETSLTV 185

Query: 516  GQESAAMAMPQPSQEGISEILGQESVTAEKLPTPQEETSLT-LCPDSPQNLKEEGGLDLP 574
             +E+        +    +   G+E  T+ K     E+TS   L P S    K     +  
Sbjct: 186  NKETTVETKETTTTNKQTSTDGKEKTTSAKETQSIEKTSAKDLAPTSKVLAKPTPKAETT 245

Query: 575  SGRKPVAAATIVPRQAKEDLTLPQDSAMTPPLPLQDTDLSSAPK-PVAAATIVSQQAEEG 633
            +       A   P++     T P++ A T P     T + SAP  P   A   ++ A   
Sbjct: 246  TK----GPALTTPKEPTP--TTPKEPASTTPKEPTPTTIKSAPTTPKEPAPTTTKSAPTT 299

Query: 634  LTLPQDSVMTPPLPLQDTE----LSSAPKPVAAATLVSQQAEEGLTLPQDSAMTPPLPLQ 689
               P  +    P P    E     +  P P    +  +   E   T P+  A T P    
Sbjct: 300  PKEPAPTTTKEPAPTTPKEPAPTTTKEPAPTTTKSAPTTPKEPAPTTPKKPAPTTPKEPA 359

Query: 690  DTDLSSAPKPVAAATLVSQQAEEGLTLPQDSAMTPPL-PLQDTDLSSAPK-PVAAATLVS 747
             T     P P           E   T P++ A T P  P   T    AP  P   A   +
Sbjct: 360  PTT-PKEPTPTTPKEPAPTTKEPAPTTPKEPAPTAPKKPAPTTPKEPAPTTPKEPAPTTT 418

Query: 748  QQAEEGLTLPQDSAMTPPLPLQDTDLSSAPKPVAAATIVSQQA------EEGLTLPQDSA 801
            +  E   T P++ A T       T    AP    +A    ++       E   T P++ A
Sbjct: 419  K--EPSPTTPKEPAPTTTKSAPTTTKEPAPTTTKSAPTTPKEPSPTTTKEPAPTTPKEPA 476

Query: 802  -MTPPLPLQDTDLSSAP----KPVAAAT---IVSQQAEEGLTLPQDSAMTPPLPLQDTDL 853
              TP  P   T    AP    +P    T     +   E   T P+++A T P  L  T  
Sbjct: 477  PTTPKKPAPTTPKEPAPTTPKEPAPTTTKKPAPTTPKEPAPTTPKETAPTTPKKLTPT-- 534

Query: 854  SSAPKPVAAATPVSQQAEEGLTLPQDSA-MTPPLPLQDTDLSSAPKPVAAATPVSQQAEE 912
               P+ +A  TP     +   T P++ A  TP  P   T    AP    AA P +   E 
Sbjct: 535  --TPEKLAPTTP----EKPAPTTPEELAPTTPEEPTPTTPEEPAPTTPKAAAP-NTPKEP 587

Query: 913  GLTLPQDSAMTAPLPLQDTGPTSGPEPLAVATPQTLQAEAGCAPGT--EPVATMAQQEVG 970
              T P++ A T P   ++  PT+ P+  A  TP+      G AP T  EP  T  ++   
Sbjct: 588  APTTPKEPAPTTP---KEPAPTT-PKETAPTTPK------GTAPTTLKEPAPTTPKKPAP 637

Query: 971  EALGP------------RPAPEEKNAALPTVP-EPAALDQVQQDDPQPAAEAGT-PWAAQ 1016
            + L P            +PAP       PT P EPA        +P P    GT P   +
Sbjct: 638  KELAPTTTKEPTSTTCDKPAPTTPKGTAPTTPKEPA---PTTPKEPAPTTPKGTAPTTLK 694

Query: 1017 EDA--------------DSTLGMEALSLPEPASGAGEEIAEALSRPGREACLEARAHTGD 1062
            E A               +T G  + +  +PA    +E A    +       +  A T  
Sbjct: 695  EPAPTTPKKPAPKELAPTTTKGPTSTTSDKPAPTTPKETAPTTPKEPAPTTPKKPAPTTP 754

Query: 1063 GAKPDSPQ--------KETLEVENQQEGGLKPLAQEHGPRSALGGAREVPDAPPAACPEV 1114
               P +          KE   +    +     L+ E  P+ AL  + + P  P    P  
Sbjct: 755  ETPPPTTSEVSTPTTTKEPTTIHKSPDESTPELSAEPTPK-ALENSPKEPGVPTTKTPAA 813

Query: 1115 SQARLLSPARE---ERGLSGKSTPEPTLPSAVATEASLDSCPESSVGAVSSLDRGCPDAP 1171
            ++  + + A++   ER L  ++TPE T  +   T+ +  +  +++   +++         
Sbjct: 814  TKPEMTTTAKDKTTERDL--RTTPETTTAAPKMTKETATTTEKTTESKITA-------TT 864

Query: 1172 APTSAPTSQQPEP--VLGLGSVEQPHEV----PSVLGTPLLQPPENLAKGQPSTPVDRPL 1225
               ++ T+Q   P  +  L +     +V     ++  T ++  PE  AK +      +  
Sbjct: 865  TQVTSTTTQDTTPFKITTLKTTTLAPKVTTTKKTITTTEIMNKPEETAKPKDRATNSKAT 924

Query: 1226 GPDPSAPGTLAGAALPPLEPPAPCLCQDPQEDSVEDEEPPGSLGLPPPQAGVQPAAAAVS 1285
             P P           P   P  P   + P+  ++     P +   P       P     S
Sbjct: 925  TPKPQK---------PTKAPKKPTSTKKPK--TMPRVRKPKTTPTPRKMTSTMPELNPTS 973

Query: 1286 GTTQP-LGTGPRVSLSPHSPLLSPKVASMDA 1315
               +  L T  R + +P+S L+     S DA
Sbjct: 974  RIAEAMLQTTTRPNQTPNSKLVEVNPKSEDA 1004


>gi|189181720 proteoglycan 4 isoform B [Homo sapiens]
          Length = 1363

 Score = 94.7 bits (234), Expect = 6e-19
 Identities = 205/931 (22%), Positives = 322/931 (34%), Gaps = 135/931 (14%)

Query: 468  VTEEGLALGQESTATVTPHTL-----QVAPGLQVEVATRVTPQAG-------EEETDSTA 515
            V E G  L        TP T      +V+   ++  A  + P+          +ET  T 
Sbjct: 178  VDEAGSGLDNGDFKVTTPDTSTTQHNKVSTSPKITTAKPINPRPSLPPNSDTSKETSLTV 237

Query: 516  GQESAAMAMPQPSQEGISEILGQESVTAEKLPTPQEETSLT-LCPDSPQNLKEEGGLDLP 574
             +E+        +    +   G+E  T+ K     E+TS   L P S    K     +  
Sbjct: 238  NKETTVETKETTTTNKQTSTDGKEKTTSAKETQSIEKTSAKDLAPTSKVLAKPTPKAETT 297

Query: 575  SGRKPVAAATIVPRQAKEDLTLPQDSAMTPPLPLQDTDLSSAPK-PVAAATIVSQQAEEG 633
            +       A   P++     T P++ A T P     T + SAP  P   A   ++ A   
Sbjct: 298  TK----GPALTTPKEPTP--TTPKEPASTTPKEPTPTTIKSAPTTPKEPAPTTTKSAPTT 351

Query: 634  LTLPQDSVMTPPLPLQDTE----LSSAPKPVAAATLVSQQAEEGLTLPQDSAMTPPLPLQ 689
               P  +    P P    E     +  P P    +  +   E   T P+  A T P    
Sbjct: 352  PKEPAPTTTKEPAPTTPKEPAPTTTKEPAPTTTKSAPTTPKEPAPTTPKKPAPTTPKEPA 411

Query: 690  DTDLSSAPKPVAAATLVSQQAEEGLTLPQDSAMTPPL-PLQDTDLSSAPK-PVAAATLVS 747
             T     P P           E   T P++ A T P  P   T    AP  P   A   +
Sbjct: 412  PTT-PKEPTPTTPKEPAPTTKEPAPTTPKEPAPTAPKKPAPTTPKEPAPTTPKEPAPTTT 470

Query: 748  QQAEEGLTLPQDSAMTPPLPLQDTDLSSAPKPVAAATIVSQQA------EEGLTLPQDSA 801
            +  E   T P++ A T       T    AP    +A    ++       E   T P++ A
Sbjct: 471  K--EPSPTTPKEPAPTTTKSAPTTTKEPAPTTTKSAPTTPKEPSPTTTKEPAPTTPKEPA 528

Query: 802  -MTPPLPLQDTDLSSAP----KPVAAAT---IVSQQAEEGLTLPQDSAMTPPLPLQDTDL 853
              TP  P   T    AP    +P    T     +   E   T P+++A T P  L  T  
Sbjct: 529  PTTPKKPAPTTPKEPAPTTPKEPAPTTTKKPAPTTPKEPAPTTPKETAPTTPKKLTPT-- 586

Query: 854  SSAPKPVAAATPVSQQAEEGLTLPQDSA-MTPPLPLQDTDLSSAPKPVAAATPVSQQAEE 912
               P+ +A  TP     +   T P++ A  TP  P   T    AP    AA P +   E 
Sbjct: 587  --TPEKLAPTTP----EKPAPTTPEELAPTTPEEPTPTTPEEPAPTTPKAAAP-NTPKEP 639

Query: 913  GLTLPQDSAMTAPLPLQDTGPTSGPEPLAVATPQTLQAEAGCAPGT--EPVATMAQQEVG 970
              T P++ A T P   ++  PT+ P+  A  TP+      G AP T  EP  T  ++   
Sbjct: 640  APTTPKEPAPTTP---KEPAPTT-PKETAPTTPK------GTAPTTLKEPAPTTPKKPAP 689

Query: 971  EALGP------------RPAPEEKNAALPTVP-EPAALDQVQQDDPQPAAEAGT-PWAAQ 1016
            + L P            +PAP       PT P EPA        +P P    GT P   +
Sbjct: 690  KELAPTTTKEPTSTTCDKPAPTTPKGTAPTTPKEPA---PTTPKEPAPTTPKGTAPTTLK 746

Query: 1017 EDA--------------DSTLGMEALSLPEPASGAGEEIAEALSRPGREACLEARAHTGD 1062
            E A               +T G  + +  +PA    +E A    +       +  A T  
Sbjct: 747  EPAPTTPKKPAPKELAPTTTKGPTSTTSDKPAPTTPKETAPTTPKEPAPTTPKKPAPTTP 806

Query: 1063 GAKPDSPQ--------KETLEVENQQEGGLKPLAQEHGPRSALGGAREVPDAPPAACPEV 1114
               P +          KE   +    +     L+ E  P+ AL  + + P  P    P  
Sbjct: 807  ETPPPTTSEVSTPTTTKEPTTIHKSPDESTPELSAEPTPK-ALENSPKEPGVPTTKTPAA 865

Query: 1115 SQARLLSPARE---ERGLSGKSTPEPTLPSAVATEASLDSCPESSVGAVSSLDRGCPDAP 1171
            ++  + + A++   ER L  ++TPE T  +   T+ +  +  +++   +++         
Sbjct: 866  TKPEMTTTAKDKTTERDL--RTTPETTTAAPKMTKETATTTEKTTESKITA-------TT 916

Query: 1172 APTSAPTSQQPEP--VLGLGSVEQPHEV----PSVLGTPLLQPPENLAKGQPSTPVDRPL 1225
               ++ T+Q   P  +  L +     +V     ++  T ++  PE  AK +      +  
Sbjct: 917  TQVTSTTTQDTTPFKITTLKTTTLAPKVTTTKKTITTTEIMNKPEETAKPKDRATNSKAT 976

Query: 1226 GPDPSAPGTLAGAALPPLEPPAPCLCQDPQEDSVEDEEPPGSLGLPPPQAGVQPAAAAVS 1285
             P P           P   P  P   + P+  ++     P +   P       P     S
Sbjct: 977  TPKPQK---------PTKAPKKPTSTKKPK--TMPRVRKPKTTPTPRKMTSTMPELNPTS 1025

Query: 1286 GTTQP-LGTGPRVSLSPHSPLLSPKVASMDA 1315
               +  L T  R + +P+S L+     S DA
Sbjct: 1026 RIAEAMLQTTTRPNQTPNSKLVEVNPKSEDA 1056


>gi|67190163 proteoglycan 4 isoform A [Homo sapiens]
          Length = 1404

 Score = 94.7 bits (234), Expect = 6e-19
 Identities = 205/931 (22%), Positives = 322/931 (34%), Gaps = 135/931 (14%)

Query: 468  VTEEGLALGQESTATVTPHTL-----QVAPGLQVEVATRVTPQAG-------EEETDSTA 515
            V E G  L        TP T      +V+   ++  A  + P+          +ET  T 
Sbjct: 219  VDEAGSGLDNGDFKVTTPDTSTTQHNKVSTSPKITTAKPINPRPSLPPNSDTSKETSLTV 278

Query: 516  GQESAAMAMPQPSQEGISEILGQESVTAEKLPTPQEETSLT-LCPDSPQNLKEEGGLDLP 574
             +E+        +    +   G+E  T+ K     E+TS   L P S    K     +  
Sbjct: 279  NKETTVETKETTTTNKQTSTDGKEKTTSAKETQSIEKTSAKDLAPTSKVLAKPTPKAETT 338

Query: 575  SGRKPVAAATIVPRQAKEDLTLPQDSAMTPPLPLQDTDLSSAPK-PVAAATIVSQQAEEG 633
            +       A   P++     T P++ A T P     T + SAP  P   A   ++ A   
Sbjct: 339  TK----GPALTTPKEPTP--TTPKEPASTTPKEPTPTTIKSAPTTPKEPAPTTTKSAPTT 392

Query: 634  LTLPQDSVMTPPLPLQDTE----LSSAPKPVAAATLVSQQAEEGLTLPQDSAMTPPLPLQ 689
               P  +    P P    E     +  P P    +  +   E   T P+  A T P    
Sbjct: 393  PKEPAPTTTKEPAPTTPKEPAPTTTKEPAPTTTKSAPTTPKEPAPTTPKKPAPTTPKEPA 452

Query: 690  DTDLSSAPKPVAAATLVSQQAEEGLTLPQDSAMTPPL-PLQDTDLSSAPK-PVAAATLVS 747
             T     P P           E   T P++ A T P  P   T    AP  P   A   +
Sbjct: 453  PTT-PKEPTPTTPKEPAPTTKEPAPTTPKEPAPTAPKKPAPTTPKEPAPTTPKEPAPTTT 511

Query: 748  QQAEEGLTLPQDSAMTPPLPLQDTDLSSAPKPVAAATIVSQQA------EEGLTLPQDSA 801
            +  E   T P++ A T       T    AP    +A    ++       E   T P++ A
Sbjct: 512  K--EPSPTTPKEPAPTTTKSAPTTTKEPAPTTTKSAPTTPKEPSPTTTKEPAPTTPKEPA 569

Query: 802  -MTPPLPLQDTDLSSAP----KPVAAAT---IVSQQAEEGLTLPQDSAMTPPLPLQDTDL 853
              TP  P   T    AP    +P    T     +   E   T P+++A T P  L  T  
Sbjct: 570  PTTPKKPAPTTPKEPAPTTPKEPAPTTTKKPAPTTPKEPAPTTPKETAPTTPKKLTPT-- 627

Query: 854  SSAPKPVAAATPVSQQAEEGLTLPQDSA-MTPPLPLQDTDLSSAPKPVAAATPVSQQAEE 912
               P+ +A  TP     +   T P++ A  TP  P   T    AP    AA P +   E 
Sbjct: 628  --TPEKLAPTTP----EKPAPTTPEELAPTTPEEPTPTTPEEPAPTTPKAAAP-NTPKEP 680

Query: 913  GLTLPQDSAMTAPLPLQDTGPTSGPEPLAVATPQTLQAEAGCAPGT--EPVATMAQQEVG 970
              T P++ A T P   ++  PT+ P+  A  TP+      G AP T  EP  T  ++   
Sbjct: 681  APTTPKEPAPTTP---KEPAPTT-PKETAPTTPK------GTAPTTLKEPAPTTPKKPAP 730

Query: 971  EALGP------------RPAPEEKNAALPTVP-EPAALDQVQQDDPQPAAEAGT-PWAAQ 1016
            + L P            +PAP       PT P EPA        +P P    GT P   +
Sbjct: 731  KELAPTTTKEPTSTTCDKPAPTTPKGTAPTTPKEPA---PTTPKEPAPTTPKGTAPTTLK 787

Query: 1017 EDA--------------DSTLGMEALSLPEPASGAGEEIAEALSRPGREACLEARAHTGD 1062
            E A               +T G  + +  +PA    +E A    +       +  A T  
Sbjct: 788  EPAPTTPKKPAPKELAPTTTKGPTSTTSDKPAPTTPKETAPTTPKEPAPTTPKKPAPTTP 847

Query: 1063 GAKPDSPQ--------KETLEVENQQEGGLKPLAQEHGPRSALGGAREVPDAPPAACPEV 1114
               P +          KE   +    +     L+ E  P+ AL  + + P  P    P  
Sbjct: 848  ETPPPTTSEVSTPTTTKEPTTIHKSPDESTPELSAEPTPK-ALENSPKEPGVPTTKTPAA 906

Query: 1115 SQARLLSPARE---ERGLSGKSTPEPTLPSAVATEASLDSCPESSVGAVSSLDRGCPDAP 1171
            ++  + + A++   ER L  ++TPE T  +   T+ +  +  +++   +++         
Sbjct: 907  TKPEMTTTAKDKTTERDL--RTTPETTTAAPKMTKETATTTEKTTESKITA-------TT 957

Query: 1172 APTSAPTSQQPEP--VLGLGSVEQPHEV----PSVLGTPLLQPPENLAKGQPSTPVDRPL 1225
               ++ T+Q   P  +  L +     +V     ++  T ++  PE  AK +      +  
Sbjct: 958  TQVTSTTTQDTTPFKITTLKTTTLAPKVTTTKKTITTTEIMNKPEETAKPKDRATNSKAT 1017

Query: 1226 GPDPSAPGTLAGAALPPLEPPAPCLCQDPQEDSVEDEEPPGSLGLPPPQAGVQPAAAAVS 1285
             P P           P   P  P   + P+  ++     P +   P       P     S
Sbjct: 1018 TPKPQK---------PTKAPKKPTSTKKPK--TMPRVRKPKTTPTPRKMTSTMPELNPTS 1066

Query: 1286 GTTQP-LGTGPRVSLSPHSPLLSPKVASMDA 1315
               +  L T  R + +P+S L+     S DA
Sbjct: 1067 RIAEAMLQTTTRPNQTPNSKLVEVNPKSEDA 1097


>gi|146219843 Snf2-related CBP activator protein [Homo sapiens]
          Length = 3230

 Score = 90.1 bits (222), Expect = 1e-17
 Identities = 216/890 (24%), Positives = 308/890 (34%), Gaps = 154/890 (17%)

Query: 603  TPPLPLQDTDLSSAPKPVAAATIVSQQAEEGLTLPQDSVMTPPLPLQDTELSSAPKPVAA 662
            TPP P++   LS AP P +++ +       G T P  +  T          ++ P P  A
Sbjct: 1109 TPPAPVR---LSPAPPPGSSSLLKPLTVPPGYTFPPAAATTTSTTTATATTTAVPAPTPA 1165

Query: 663  ATLVSQQAEEGLTLPQDSAMTPPLPLQDTDLSSAPKPVAAA----TLVSQQAEEGLTLP- 717
               +    +    LP    ++          S A +PVA A     L  Q     LTL  
Sbjct: 1166 PQRLILSPDMQARLPSGEVVSI-----GQLASLAQRPVANAGGSKPLTFQIQGNKLTLTG 1220

Query: 718  ---QDSAMTPPLPLQDTDLSSAPKPVAAATLVSQQAEEGLTLPQDSAMTP-PLPLQDTDL 773
               +  A+  P PLQ  ++           L+SQ A   + L Q  A TP P P+     
Sbjct: 1221 AQVRQLAVGQPRPLQ-RNVVHLVSAGGQHHLISQPAH--VALIQAVAPTPGPTPVSVLP- 1276

Query: 774  SSAPKPVAAATIVSQQAEEGLTLPQDSAMTPPLPLQDTDL-----SSAPK----PVAAAT 824
            SS P    A T        GL+LP  +   PP  + +T +       AP+    PV    
Sbjct: 1277 SSTPSTTPAPT--------GLSLPLAANQVPPTMVNNTGVVKIVVRQAPRDGLTPVPPLA 1328

Query: 825  IVSQQAEEGL--TLPQDSAMTP---PLPLQDTDLSSAPKPVAAATPV----SQQAEEGLT 875
               +    GL   L     +TP   P P   T  +  P P      +    S   E   +
Sbjct: 1329 PAPRPPSSGLPAVLNPRPTLTPGRLPTPTLGTARAPMPTPTLVRPLLKLVHSPSPEVSAS 1388

Query: 876  LPQDSAMTPPLPLQDTDL----SSAPKPVAAATPVSQQAEEGLTLPQDSAMTAPLPLQDT 931
             P  + +T   PL         +S+P P+  ++P++      +++P  S++   +P    
Sbjct: 1389 APGAAPLTISSPLHVPSSLPGPASSPMPIPNSSPLASPVSSTVSVPLSSSLPISVPTTLP 1448

Query: 932  GPTSGPEPLAVATPQTLQAE---------------AGCAPGTEPVATMAQQEVGEA--LG 974
             P S P  + ++ P T+ A                   APG   +A         A  LG
Sbjct: 1449 APASAPLTIPISAPLTVSASGPALLTSVTPPLAPVVPAAPGPPSLAPSGASPSASALTLG 1508

Query: 975  PRPAPEEKNAALPTVP---------------------EPAALDQVQQDDPQPAAEAGTPW 1013
               AP   ++  P  P                      P  +       P P+A    P 
Sbjct: 1509 LATAPSLSSSQTPGHPLLLAPTSSHVPGLNSTVAPACSPVLVPASALASPFPSAPNPAPA 1568

Query: 1014 AAQEDADSTLGMEALSLPEPASGAGEEIAEALSRPGREACLEARAHTGDGAKPDSPQKET 1073
             A   A ++   +AL+ P     A +    A S     A L   A    GA P     +T
Sbjct: 1569 QASLLAPASSASQALATPLAPMAAPQTAILAPSPAPPLAPLPVLA-PSPGAAPVLASSQT 1627

Query: 1074 LEVENQQEGGLKPLAQEHGPRSALGGAREVPDAPPAACPEVSQARLLSPAREERGLSGKS 1133
                      +  +A    P ++L  A  VP   P   P  +Q  L +P           
Sbjct: 1628 ---------PVPVMAPSSTPGTSLASASPVPAPTPVLAPSSTQTMLPAP----------- 1667

Query: 1134 TPEPTLPSAVATE------ASLDSCPESSVGAVSSLDRGCPDAPAPTSAPTSQQPEPVLG 1187
             P P LPS  +T+      A   +   SS     SL  G P  P PT    S  P   L 
Sbjct: 1668 VPSP-LPSPASTQTLALAPALAPTLGGSSPSQTLSLGTGNPQGPFPTQT-LSLTPASSL- 1724

Query: 1188 LGSVEQPHEVPSVLGTPLLQPPE--NLAKGQPSTPVDRPLGPDPSAPGTLAGAALPPLEP 1245
               V  P +  S+   P L P +  +LA   P  P   P+GP P+   TLA     P   
Sbjct: 1725 ---VPTPAQTLSLAPGPPLGPTQTLSLAPAPPLAPAS-PVGPAPAHTLTLA-----PASS 1775

Query: 1246 PAPCLCQDPQEDSVEDEEPPGSLGLPPPQAGVQPAAAAVSGTTQPLGTGPR--VSLSPHS 1303
             A  L     +       P  +LG     A  Q  A A + T  P        VS S  +
Sbjct: 1776 SASLLAPASVQTLTLSPAPVPTLG----PAAAQTLALAPASTQSPASQASSLVVSASGAA 1831

Query: 1304 PL----LSPKVASMDAKD-LALQILPPCQVPPPSGPQSPAGPQGLSAPEQQEDE----DS 1354
            PL    +S    S D  D L L+  PP    PPS   S  GP+    P          DS
Sbjct: 1832 PLPVTMVSRLPVSKDEPDTLTLRSGPP---SPPSTATSFGGPRPRRQPPPPPRSPFYLDS 1888

Query: 1355 LEEDSPRALGSG-----QHSDSHGESSAELDEQDILAPQTVQCPAQAPAG 1399
            LEE   R          Q S++HG + A +   ++L   T+  P  +P G
Sbjct: 1889 LEEKRKRQRSERLERIFQLSEAHG-ALAPVYGTEVLDFCTLPQPVASPIG 1937



 Score = 89.4 bits (220), Expect = 3e-17
 Identities = 230/994 (23%), Positives = 338/994 (34%), Gaps = 185/994 (18%)

Query: 91   PSPMLLPEGLSSQALSTEAPLPATLEPRIVMGEETCQALLSPRAARTALRDQEGGHASPD 150
            P P   P+ +  +      P+P   E R V+     +A L P   R            P 
Sbjct: 981  PDPPPRPKPVKMKVNRMLQPVPKQ-EGRTVVVVNNPRAPLGPVPVR------------PP 1027

Query: 151  PPPELCSQGDLSVPSPPPDPDSFFTPPSTPTKTTYA---LLPACGPHGDARDSEAELRDE 207
            P PEL +Q     P+P P P     P S     + A   L+PA  P G       +    
Sbjct: 1028 PGPELSAQ-----PTPGPVPQVL--PASLMVSASPAGPPLIPASRPPGPVLLPPLQPNSG 1080

Query: 208  LLDSPPASPSGSYITADGDSWASSPSCSLSLLAPAEGLDFPSGWGLSPQGSMVDERELH- 266
             L     SP G      G S   +P+ SL    PA     P+     P GS    + L  
Sbjct: 1081 SLPQVLPSPLG---VLSGTSRPPTPTLSLKPTPPAPVRLSPA----PPPGSSSLLKPLTV 1133

Query: 267  PAGTPEPPSSESSLSADSSSSWGQEGHFFDLDFLANDPMIPAALLPFQGSLIFQVEAVEV 326
            P G   PP++ ++ S  +++              A    +PA   P    LI        
Sbjct: 1134 PPGYTFPPAAATTTSTTTAT--------------ATTTAVPAPT-PAPQRLI-------- 1170

Query: 327  TPLSPEEEEEEAVADPDPGGDLAGEGEEDSTSASFLQSLSDLSITE-GMDEAFAFRDDTS 385
              LSP+ +         P G++   G+        L SL+   +   G  +   F+    
Sbjct: 1171 --LSPDMQARL------PSGEVVSIGQ--------LASLAQRPVANAGGSKPLTFQ---- 1210

Query: 386  AASSDSDSASYAEADDERLYSGEPHAQATLLQDSVQKTEEESGGGAKGLQAQDGTVSWAV 445
                  +  +   A   +L  G+P      LQ +V      S GG   L +Q   V+   
Sbjct: 1211 ---IQGNKLTLTGAQVRQLAVGQPRP----LQRNV--VHLVSAGGQHHLISQPAHVALIQ 1261

Query: 446  EAAPQTSDRGAYLSQRQELISEVTEEGLALGQESTATVTPHTLQVAPGLQVEVATRVTPQ 505
              AP        +       +     GL+L     A   P T+    G+ V++  R  P+
Sbjct: 1262 AVAPTPGPTPVSVLPSSTPSTTPAPTGLSL--PLAANQVPPTMVNNTGV-VKIVVRQAPR 1318

Query: 506  AGEEETDSTAGQESAAMAMPQPSQEGISEILG-QESVTAEKLPTPQEETSLTLCPD---- 560
             G       A         P+P   G+  +L  + ++T  +LPTP   T+    P     
Sbjct: 1319 DGLTPVPPLA-------PAPRPPSSGLPAVLNPRPTLTPGRLPTPTLGTARAPMPTPTLV 1371

Query: 561  ----------SPQNLKEEGGLDLPSGRKPVAAATIVPRQAKEDLTLPQDSAMTPPLPLQD 610
                      SP+      G    +   P+   + +P  A   + +P  S +  P+    
Sbjct: 1372 RPLLKLVHSPSPEVSASAPGAAPLTISSPLHVPSSLPGPASSPMPIPNSSPLASPVSSTV 1431

Query: 611  TDLSSAPKPVAAATIVSQQAEEGLTLPQDSVM-------------TPPLPLQDTELSSAP 657
            +   S+  P++  T +   A   LT+P  + +             TPPL      + +AP
Sbjct: 1432 SVPLSSSLPISVPTTLPAPASAPLTIPISAPLTVSASGPALLTSVTPPLA---PVVPAAP 1488

Query: 658  KPVAAATLVSQQAEEGLTL------PQDSAMTP--PLPLQDTD-----LSSAPKPVAAAT 704
             P + A   +  +   LTL         S+ TP  PL L  T      L+S   P  +  
Sbjct: 1489 GPPSLAPSGASPSASALTLGLATAPSLSSSQTPGHPLLLAPTSSHVPGLNSTVAPACSPV 1548

Query: 705  LVSQQAEEGLTLPQDSAMTPPLPLQDTDL---SSAPKPVAAATLVSQQAEEGLTLPQDSA 761
            LV   A   L  P  SA   P P Q + L   SSA + +A         +  +  P  + 
Sbjct: 1549 LVPASA---LASPFPSAPN-PAPAQASLLAPASSASQALATPLAPMAAPQTAILAPSPAP 1604

Query: 762  MTPPLPLQDTDLSSAPKPVAAATIVSQQAEEGLTLPQDSAMTPPLPLQDTDLSSAPKPVA 821
               PLP+       AP P AA  + S Q    +  P   + TP   L       AP PV 
Sbjct: 1605 PLAPLPV------LAPSPGAAPVLASSQTPVPVMAP---SSTPGTSLASASPVPAPTPVL 1655

Query: 822  AATIVSQQAEEGLTLPQDSAMTPPLPLQDTDLSSAPKPVAAATPVSQQAEEGLTLPQDSA 881
            A +      +  L  P  S +  P   Q   L+ A  P    +  SQ    G   PQ   
Sbjct: 1656 APS----STQTMLPAPVPSPLPSPASTQTLALAPALAPTLGGSSPSQTLSLGTGNPQGPF 1711

Query: 882  MT------------------------PPL-PLQDTDLSSAPKPVAAATPVSQQAEEGLTL 916
             T                        PPL P Q   L+ AP P+A A+PV       LTL
Sbjct: 1712 PTQTLSLTPASSLVPTPAQTLSLAPGPPLGPTQTLSLAPAP-PLAPASPVGPAPAHTLTL 1770

Query: 917  -PQDSAMTAPLPLQDTGPTSGPEPLAVATPQTLQAEAGCAPGTEPVATMAQQEVGEALGP 975
             P  S+ +   P      T  P P+    P   Q  A     T+  A+ A   V  A G 
Sbjct: 1771 APASSSASLLAPASVQTLTLSPAPVPTLGPAAAQTLALAPASTQSPASQASSLVVSASGA 1830

Query: 976  RPAPEEKNAALPTVPEPAALDQVQQDDPQPAAEA 1009
             P P    + LP   +      ++   P P + A
Sbjct: 1831 APLPVTMVSRLPVSKDEPDTLTLRSGPPSPPSTA 1864



 Score = 84.3 bits (207), Expect = 8e-16
 Identities = 204/825 (24%), Positives = 298/825 (36%), Gaps = 154/825 (18%)

Query: 617  PKPVA---AATIVSQQAEEGLTLPQDSVMTPPLPLQDTEL-----SSAPK----PVAAAT 664
            P PV+   ++T  +  A  GL+LP  +   PP  + +T +       AP+    PV    
Sbjct: 1269 PTPVSVLPSSTPSTTPAPTGLSLPLAANQVPPTMVNNTGVVKIVVRQAPRDGLTPVPPLA 1328

Query: 665  LVSQQAEEGL--TLPQDSAMTP---PLPLQDTDLSSAPKPVAAATLV----SQQAEEGLT 715
               +    GL   L     +TP   P P   T  +  P P     L+    S   E   +
Sbjct: 1329 PAPRPPSSGLPAVLNPRPTLTPGRLPTPTLGTARAPMPTPTLVRPLLKLVHSPSPEVSAS 1388

Query: 716  LPQDSAMTPPLPLQDTDL----SSAPKPVAAATLVSQQAEEGLTLPQDSAMTPPLPLQDT 771
             P  + +T   PL         +S+P P+  ++ ++      +++P  S++   +P    
Sbjct: 1389 APGAAPLTISSPLHVPSSLPGPASSPMPIPNSSPLASPVSSTVSVPLSSSLPISVPTTLP 1448

Query: 772  DLSSAPK--PVAAATIVSQQAEEGLTLPQDSAMTPPLPLQDTDLSSAPKPVAAATIVSQQ 829
              +SAP   P++A   VS      LT     ++TPPL      + +AP P + A   +  
Sbjct: 1449 APASAPLTIPISAPLTVSASGPALLT-----SVTPPLA---PVVPAAPGPPSLAPSGASP 1500

Query: 830  AEEGLTL------PQDSAMTP--PLPLQDTD-----LSSAPKPVAAATPVSQQAEEGLTL 876
            +   LTL         S+ TP  PL L  T      L+S   P  A +PV   A   L  
Sbjct: 1501 SASALTLGLATAPSLSSSQTPGHPLLLAPTSSHVPGLNSTVAP--ACSPVLVPAS-ALAS 1557

Query: 877  PQDSAMTPPLPLQDTDLSSAPKPVAA-ATPVSQQA--EEGLTLPQDSAMTAPLPLQDTGP 933
            P  SA  P  P Q + L+ A     A ATP++  A  +  +  P  +   APLP+    P
Sbjct: 1558 PFPSAPNPA-PAQASLLAPASSASQALATPLAPMAAPQTAILAPSPAPPLAPLPVLAPSP 1616

Query: 934  TSGPEPLAVATPQTLQAEAGCAPGTEPVATMAQQEVGEALGPRPAPEEKNAALPTVPEPA 993
             + P   +  TP  + A     P + P  ++A      A  P  AP      LP  P P+
Sbjct: 1617 GAAPVLASSQTPVPVMA-----PSSTPGTSLASASPVPAPTPVLAPSSTQTMLPA-PVPS 1670

Query: 994  ALDQVQQDDPQPAAEAGTPWAAQEDADSTLGMEALSLPEPASGAGEEIAEALSRPGREAC 1053
             L           A A  P         TL +         +  G    + LS     + 
Sbjct: 1671 PLPSPASTQTLALAPALAPTLGGSSPSQTLSLGT------GNPQGPFPTQTLSLTPASSL 1724

Query: 1054 LEARAHTGDGAKPDSPQKETLEVENQQEGGLKPLAQEHGPRSALGGAREVPDAPPAACPE 1113
            +   A T   A P  P   T      Q   L P A    P S +G A   P       P 
Sbjct: 1725 VPTPAQTLSLA-PGPPLGPT------QTLSLAP-APPLAPASPVGPA---PAHTLTLAPA 1773

Query: 1114 VSQARLLSPAREERGLSGKSTPEPTLPSAVATEASLDSCPESSVGAVSSLDRGCPDAPAP 1173
             S A LL+PA  +  L+    P PTL  A A   +L                    APA 
Sbjct: 1774 SSSASLLAPASVQT-LTLSPAPVPTLGPAAAQTLAL--------------------APAS 1812

Query: 1174 TSAPTSQQPEPVLGLGSVEQPHEVPSVLGTPLLQPPENLAKGQPSTPVDRPLGPDPSAPG 1233
            T +P SQ    V+   S   P  V  V   P+       +K +P T   R   P P +  
Sbjct: 1813 TQSPASQASSLVVS-ASGAAPLPVTMVSRLPV-------SKDEPDTLTLRSGPPSPPSTA 1864

Query: 1234 TLAGAALPPLEPPAPCLCQDPQE----DSVEDE----------------EPPGSLG---- 1269
            T  G   P  +PP P     P+     DS+E++                E  G+L     
Sbjct: 1865 TSFGGPRPRRQPPPP-----PRSPFYLDSLEEKRKRQRSERLERIFQLSEAHGALAPVYG 1919

Query: 1270 --------LPPPQAGVQPAAAAVSGTTQPLGTGPRVSLSPHSPLLSPKVASMDAKDLA-- 1319
                    LP P A   P      G + P  T    + + H  +L P+       ++   
Sbjct: 1920 TEVLDFCTLPQPVAS--PIGPRSPGPSHP--TFWTYTEAAHRAVLFPQQRLDQLSEIIER 1975

Query: 1320 -LQILPPCQVPPPSGPQSPAGPQGLSAPEQQEDEDSLEEDS-PRA 1362
             + ++PP + PPPS       P    AP Q   ++ L  +  PRA
Sbjct: 1976 FIFVMPPVEAPPPS--LHACHPPPWLAPRQAAFQEQLASELWPRA 2018



 Score = 70.9 bits (172), Expect = 9e-12
 Identities = 195/900 (21%), Positives = 302/900 (33%), Gaps = 163/900 (18%)

Query: 606  LPLQDTDLSSAPKPVAAATIVSQQAEEGLTLPQDSVMTPPLPLQDTELSSAPKPVAAATL 665
            +PL++   SS P          ++ EE +   Q  ++   L   + E        A A  
Sbjct: 2212 MPLEEPSSSSVPS-------APEEEEETVASKQTHILEQALCRAEDEEDIRAATQAKAEQ 2264

Query: 666  VSQQAE--EGLTLPQDSAMTPPLP-LQDTDLSSAPKPVAAA----TLVSQQAEEGLTLPQ 718
            V++ AE  E    P         P  +D ++S A + +AA     T + + A + L    
Sbjct: 2265 VAELAEFNENDGFPAGEGEEAGRPGAEDEEMSRAEQEIAALVEQLTPIERYAMKFLEASL 2324

Query: 719  DSAMTPPLPLQDTDLSSAPKPVAAATLVSQQAEEGLTLPQDSAMTPPLPLQDT------- 771
            +      L   +  + +A K +       Q  EE   LPQ+    P    + +       
Sbjct: 2325 EEVSREELKQAEEQVEAARKDL------DQAKEEVFRLPQEEEEGPGAGDESSCGTGGGT 2378

Query: 772  --DLSSAPKPVAAATIVSQQAEEGLTLPQDSAMTPPLPLQDTDLSSAPKPVAAATIVSQQ 829
                  A  P    T VS++        Q +  TP +    T  ++ P   + A    ++
Sbjct: 2379 HRRSKKAKAPERPGTRVSERLRGARAETQGANHTPVISAHQTRSTTTPPRCSPAR---ER 2435

Query: 830  AEEGLTLPQDSAMTPP--LPLQDTDLSSAPKPVAAATPVSQQAEEGLTLPQDSAMTPPLP 887
                   P+ +  + P  +P       SAP P++A  P++        LP     +PP P
Sbjct: 2436 VPRPAPRPRPTPASAPAAIPALVPVPVSAPVPISAPNPIT-------ILPVHILPSPPPP 2488

Query: 888  LQDTDLSS-APKPVAAATPVSQQAEEGLTLPQDSAMTAPLPLQDTGPTSGP-------EP 939
             Q    SS A  P  A TP           P  + +  P      GP S P        P
Sbjct: 2489 SQIPPCSSPACTPPPACTPPPAHTPP----PAQTCLVTPSSPLLLGPPSVPISASVTNLP 2544

Query: 940  LAVATPQTLQAEAGCAPGTEPVATMAQQEVGE------------ALGPRPAPEEKNAALP 987
            L +     L A+A  +P +  +A++A  E               A+   P  E+  +  P
Sbjct: 2545 LGLRPEAELCAQALASPESLELASVASSETSSLSLVPPKDLLPVAVEILPVSEKNLSLTP 2604

Query: 988  TVP----EPAALDQVQQDDPQPAAEAGTPWAAQEDAD---------------STLGMEAL 1028
            + P    E  ++   Q+ +   +AE  T     E  +               S    E L
Sbjct: 2605 SAPSLTLEAGSIPNGQEQEAPDSAEGTTLTVLPEGEELPLCVSESNGLELPPSAASDEPL 2664

Query: 1029 SLPEPASGAGEEIAEALS------RPGREACLEARAHTGDGAKPDSPQ----------KE 1072
              P  A    EE+ EA +      +P      E  A +   +   SP+          + 
Sbjct: 2665 QEPLEADRTSEELTEAKTPTSSPEKPQELVTAEVAAPSTSSSATSSPEGPSPARPPRRRT 2724

Query: 1073 TLEVENQQEGGLKPLAQEHGPRSALGGAREVPDAPPAACPEVSQARLLSPAREERGLSGK 1132
            + +VE + +G  +P  Q  GP       + +   P      V +  L+   R++RG +  
Sbjct: 2725 SADVEIRGQGTGRP-GQPPGP-------KVLRKLPGRLVTVVEEKELVRRRRQQRGAAST 2776

Query: 1133 STPEPTLPSAVATEASLDSCPESSVGAVSSLDRGCPDAPAPTSAPTSQQPEP-------- 1184
              P  +  SA     S+     S  G  SS   G P   AP+S+  +   +P        
Sbjct: 2777 LVPGVSETSASPGSPSV----RSMSGPESSPPIGGPCEAAPSSSLPTPPQQPFIARRHIE 2832

Query: 1185 --VLGLGSVEQPHEVPSVLGTPLLQPPENLAKGQPSTPVDRPLGPDPSAPGTLAG----- 1237
              V G GS E        +  P ++        +  +P D   G D +   TL G     
Sbjct: 2833 LGVTGGGSPENGDGALLAITPPAVKRRRGRPPKKNRSPADAGRGVDEAPSSTLKGKTNGA 2892

Query: 1238 ----------AALPPLEP----------PAPCLCQDPQEDSVEDE---EPPGSLGLPPPQ 1274
                       A P LEP          P P    +P    VE      PP +  LP P 
Sbjct: 2893 DPVPGPETLIVADPVLEPQLIPGPQPLGPQPVHRPNPLLSPVEKRRRGRPPKARDLPIPG 2952

Query: 1275 AGVQPAAAAVSGTTQPLGTGPRVS-LSPHSPLLSPKVASM--DAKDLALQILPPCQV--P 1329
                         TQP    P  S L+P  PLL    A++      + +   PP +    
Sbjct: 2953 TISSAGDGNSESRTQP---PPHPSPLTPLPPLLVCPTATVANTVTTVTISTSPPKRKRGR 3009

Query: 1330 PPSGPQSPAGPQGLSAPEQQEDEDSLEEDSPRALGSGQHSDSHGESSAELDEQDILAPQT 1389
            PP  P SP   Q    P    D  S+ E     LG  +     GES     ++D   P T
Sbjct: 3010 PPKNPPSPRPSQ---LPVLDRDSTSVLESC--GLGRRRQPQGQGESEGSSSDEDGSRPLT 3064



 Score = 59.3 bits (142), Expect = 3e-08
 Identities = 113/481 (23%), Positives = 173/481 (35%), Gaps = 79/481 (16%)

Query: 951  EAGCAPGTEPVATMAQQEVGEALGPRPAPEEKNAALPTVPEPAALDQVQQDDPQPAAEAG 1010
            EAG     +   + A+QE+  AL  +  P E+ A        A+L++V +++ + A E  
Sbjct: 2284 EAGRPGAEDEEMSRAEQEIA-ALVEQLTPIERYAMKFL---EASLEEVSREELKQAEEQV 2339

Query: 1011 TPWAAQEDADSTLGMEALSLP---EPASGAGEEIAEALSRPGREACLEARAHTGDGAKPD 1067
               AA++D D     E   LP   E   GAG+E               +   TG G    
Sbjct: 2340 E--AARKDLDQAKE-EVFRLPQEEEEGPGAGDE---------------SSCGTGGGT--- 2378

Query: 1068 SPQKETLEVENQQEGGLKPLAQEHGPRSALGGAREVPDAPPAACPEVSQARLLSPAREER 1127
               + + + +  +  G +   +  G R+   GA   P          +     SPARE R
Sbjct: 2379 --HRRSKKAKAPERPGTRVSERLRGARAETQGANHTPVISAHQTRSTTTPPRCSPARE-R 2435

Query: 1128 GLSGKSTPEPTLPSAVATEASLDSCPESSVGAVSSLD-------RGCPDAPAPTSAPTSQ 1180
                   P PT  SA A   +L   P S+   +S+ +          P  P P+  P   
Sbjct: 2436 VPRPAPRPRPTPASAPAAIPALVPVPVSAPVPISAPNPITILPVHILPSPPPPSQIPPCS 2495

Query: 1181 QPEPVLGLGSVEQPHEVPSVLGTPLLQPPENLAKGQPSTPV-----DRPLGPDPSAPGTL 1235
             P           P   P    T L+ P   L  G PS P+     + PLG  P A    
Sbjct: 2496 SPACTPPPACTPPPAHTPPPAQTCLVTPSSPLLLGPPSVPISASVTNLPLGLRPEAELCA 2555

Query: 1236 AGAALPPLEPPAPCLCQDPQEDSVEDEEPPGSLGLPPPQAGVQPAAAAVSGTTQPLGTGP 1295
               A P          +  +  SV   E   SL L PP+  + P A  +   ++      
Sbjct: 2556 QALASP----------ESLELASVASSE-TSSLSLVPPK-DLLPVAVEILPVSE-----K 2598

Query: 1296 RVSLSPHSPLLSPKVASM----------DAKDLALQILPPCQVPPPSGPQSPAGPQGLSA 1345
             +SL+P +P L+ +  S+           A+   L +LP  +  P    +S     GL  
Sbjct: 2599 NLSLTPSAPSLTLEAGSIPNGQEQEAPDSAEGTTLTVLPEGEELPLCVSES----NGLEL 2654

Query: 1346 PEQQEDEDSLEED-----SPRALGSGQHSDSHGESSAELDEQDILAPQTVQCPAQAPAGG 1400
            P     ++ L+E      +   L   +   S  E   EL   ++ AP T      +P G 
Sbjct: 2655 PPSAASDEPLQEPLEADRTSEELTEAKTPTSSPEKPQELVTAEVAAPSTSSSATSSPEGP 2714

Query: 1401 S 1401
            S
Sbjct: 2715 S 2715



 Score = 45.8 bits (107), Expect = 3e-04
 Identities = 82/302 (27%), Positives = 113/302 (37%), Gaps = 58/302 (19%)

Query: 13   PEADRPGP-RTDLSCDAAAATTILGGDRREPCALTPGPSHLALTFLPSKPGARPQPEGAS 71
            P A  P P +  L   A++A+  L      P A    P    L   P+ P A P P  A 
Sbjct: 1560 PSAPNPAPAQASLLAPASSASQALA----TPLAPMAAPQTAILAPSPAPPLA-PLPVLAP 1614

Query: 72   WDAGPGGAPSAWADPGEGGPSPMLLPEGLSSQALSTEAPLPATLEPRIVMGEETCQALL- 130
                PG AP   +      P P++ P      +L++ +P+PA   P  V+   + Q +L 
Sbjct: 1615 ---SPGAAPVLASSQT---PVPVMAPSSTPGTSLASASPVPA---PTPVLAPSSTQTMLP 1665

Query: 131  --------SPRAART-----ALRDQEGGHASPDPPPELCSQGDLSVPSPPPDPDSFFTPP 177
                    SP + +T     AL    GG +    P +  S G  +   P P      TP 
Sbjct: 1666 APVPSPLPSPASTQTLALAPALAPTLGGSS----PSQTLSLGTGNPQGPFPTQTLSLTPA 1721

Query: 178  S----TPTKT-TYALLPACGPHGDARDSEAELRDELLDSPPASPSGSYITADGDSWASSP 232
            S    TP +T + A  P  GP              L  +PP +P+     A   +   +P
Sbjct: 1722 SSLVPTPAQTLSLAPGPPLGPTQTL---------SLAPAPPLAPASPVGPAPAHTLTLAP 1772

Query: 233  -SCSLSLLAPAEGLDFPSGWGLSPQ------GSMVDERELHPAGTPEPPSSESSLSADSS 285
             S S SLLAPA          LSP        +      L PA T  P S  SSL   +S
Sbjct: 1773 ASSSASLLAPASVQTLT----LSPAPVPTLGPAAAQTLALAPASTQSPASQASSLVVSAS 1828

Query: 286  SS 287
             +
Sbjct: 1829 GA 1830



 Score = 36.2 bits (82), Expect = 0.25
 Identities = 61/262 (23%), Positives = 100/262 (38%), Gaps = 47/262 (17%)

Query: 198 RDSEAELRDELLDSPP------ASPSGSYITADGDSWASSPSCSLSLLAPAEGLDF--PS 249
           R+ E  L + L   PP      +SPS +  + D D+             P EG +   P 
Sbjct: 326 REGELPLEELLRSLPPQLLEGPSSPSQTPSSHDSDTRDG----------PEEGAEEEPPQ 375

Query: 250 GWGLSPQGSMVDERELHP-----------AGTPEPPSSESSLSADSSSSWGQEGHFFDLD 298
              + P  S V +R   P           A   E    E +++A+     G+  H  +L 
Sbjct: 376 VLEIKPPPSAVTQRNKQPWHPDEDDEEFTANEEEAEDEEDTIAAEEQLE-GEVDHAMELS 434

Query: 299 FLANDPMIPAALLPFQGSLIFQVEAVEVTPLSPEEEEEEAV----ADPDPGGDLAGEGEE 354
            LA +       L  +  L     A      S E+E+E+ V    +D +P G +  E   
Sbjct: 435 ELARE-----GELSMEELLQQYAGAYAPGSGSSEDEDEDEVDANSSDCEPEGPVEAEEPP 489

Query: 355 DSTSASFLQSLSDLSITEGMDEAFAFRDDTSAASSDS------DSASYAEADDERLYSGE 408
              S+S   S+ D S  E  + +       S+AS +S      D+ S ++AD+E     +
Sbjct: 490 QEDSSSQSDSVEDRSEDEEDEHSEEEETSGSSASEESESEESEDAQSQSQADEEE--EDD 547

Query: 409 PHAQATLLQDSVQKTEEESGGG 430
                 LL    +++E ++G G
Sbjct: 548 DFGVEYLLARDEEQSEADAGSG 569



 Score = 36.2 bits (82), Expect = 0.25
 Identities = 167/729 (22%), Positives = 234/729 (32%), Gaps = 128/729 (17%)

Query: 44   ALTPGPSHLALTFLPSK-PGARPQPEGASWDAGPGGAPSAWAD------------PGEG- 89
            A TPGP+ +++  LPS  P   P P G S        P    +            P +G 
Sbjct: 1264 APTPGPTPVSV--LPSSTPSTTPAPTGLSLPLAANQVPPTMVNNTGVVKIVVRQAPRDGL 1321

Query: 90   GPSPMLLPEGLSSQALSTEAPLPATLEPRIVMGE-----ETCQALLSPRAARTALRDQEG 144
             P P L P           + LPA L PR  +        T     +P    T +R    
Sbjct: 1322 TPVPPLAPA-----PRPPSSGLPAVLNPRPTLTPGRLPTPTLGTARAPMPTPTLVRPLLK 1376

Query: 145  GHASPDPPPELCSQG--DLSVPSPPPDPDSFFTPPSTPTKTTYALLPACGPHGDARDSEA 202
               SP P     + G   L++ SP   P S   P S+P       +P   P      S  
Sbjct: 1377 LVHSPSPEVSASAPGAAPLTISSPLHVPSSLPGPASSPMP-----IPNSSPLASPVSSTV 1431

Query: 203  ELR---------DELLDSPPASPSGSYITADGDSWASSPSCSLSLLAPAEGL--DFPSGW 251
             +             L +P ++P    I+A     AS P+   S+  P   +    P   
Sbjct: 1432 SVPLSSSLPISVPTTLPAPASAPLTIPISAPLTVSASGPALLTSVTPPLAPVVPAAPGPP 1491

Query: 252  GLSPQGSMVDERELHPAGTPEPPSSESS-------LSADSSSSWGQEGHFFDLDFLANDP 304
             L+P G+      L   G    PS  SS       L A +SS     G    +    +  
Sbjct: 1492 SLAPSGASPSASAL-TLGLATAPSLSSSQTPGHPLLLAPTSSH--VPGLNSTVAPACSPV 1548

Query: 305  MIPAALL-----------PFQGSLIFQVEAVE---VTPLSPEEEEEEAVADPDPGGDLAG 350
            ++PA+ L           P Q SL+    +      TPL+P    + A+  P P   LA 
Sbjct: 1549 LVPASALASPFPSAPNPAPAQASLLAPASSASQALATPLAPMAAPQTAILAPSPAPPLA- 1607

Query: 351  EGEEDSTSASFLQSLSDLSITEGMDEAFAFRDD--TSAASSDSDSASYAEADDERLYSGE 408
                          L  L+ + G     A         A S +   S A A      S  
Sbjct: 1608 -------------PLPVLAPSPGAAPVLASSQTPVPVMAPSSTPGTSLASA------SPV 1648

Query: 409  PHAQATLLQDSVQKTEEESGGGAKGLQAQDGTVSWAVEAAPQTSDRGAYLSQRQEL---- 464
            P     L   S Q              A   T++ A   AP     G+  SQ   L    
Sbjct: 1649 PAPTPVLAPSSTQTMLPAPVPSPLPSPASTQTLALAPALAPTLG--GSSPSQTLSLGTGN 1706

Query: 465  -ISEVTEEGLALGQESTATVTP-HTLQVAPGLQVEVATRVTPQAGEEETDSTAGQESAAM 522
                   + L+L   S+   TP  TL +APG          P  G  +T S A     A 
Sbjct: 1707 PQGPFPTQTLSLTPASSLVPTPAQTLSLAPG----------PPLGPTQTLSLAPAPPLAP 1756

Query: 523  AMPQPSQEGISEILGQESVTAEKLPTPQEETSLTLCPDSPQNLKEEGGLDL----PSGRK 578
            A P       +  L   S +A  L  P    +LTL P     L       L     S + 
Sbjct: 1757 ASPVGPAPAHTLTLAPASSSASLL-APASVQTLTLSPAPVPTLGPAAAQTLALAPASTQS 1815

Query: 579  PVAAATIVPRQAKEDLTLPQDSAMTPPLPLQDTDL----SSAPKPVAAATIVSQQAEEGL 634
            P + A+ +   A     LP       P+   + D     S  P P + AT          
Sbjct: 1816 PASQASSLVVSASGAAPLPVTMVSRLPVSKDEPDTLTLRSGPPSPPSTATSFGG------ 1869

Query: 635  TLPQDSVMTPPLPLQDTELSSAPKPVAAATLVSQQAEEGLTLPQ-DSAMTPPLPLQDTDL 693
              P+     PP P     L S  +        S++ E    L +   A+ P    +  D 
Sbjct: 1870 --PRPRRQPPPPPRSPFYLDSLEEKRKRQR--SERLERIFQLSEAHGALAPVYGTEVLDF 1925

Query: 694  SSAPKPVAA 702
             + P+PVA+
Sbjct: 1926 CTLPQPVAS 1934



 Score = 33.1 bits (74), Expect = 2.2
 Identities = 44/168 (26%), Positives = 58/168 (34%), Gaps = 26/168 (15%)

Query: 1224 PLGPDPSAPGTLAGAALPPLEPPAPCL--------CQDPQEDSVEDEEPPGSLGLPP--P 1273
            PLGP P  P      +  P   P P +                +    PPG + LPP  P
Sbjct: 1018 PLGPVPVRPPPGPELSAQPTPGPVPQVLPASLMVSASPAGPPLIPASRPPGPVLLPPLQP 1077

Query: 1274 QAGVQPAA-----AAVSGTTQPLGTGPRVSLSPHSPL---LSPKVASMDAKDLALQILPP 1325
             +G  P         +SGT++P    P +SL P  P    LSP      +  L    +PP
Sbjct: 1078 NSGSLPQVLPSPLGVLSGTSRP--PTPTLSLKPTPPAPVRLSPAPPPGSSSLLKPLTVPP 1135

Query: 1326 CQVPPP------SGPQSPAGPQGLSAPEQQEDEDSLEEDSPRALGSGQ 1367
                PP      S   + A    + AP        L  D    L SG+
Sbjct: 1136 GYTFPPAAATTTSTTTATATTTAVPAPTPAPQRLILSPDMQARLPSGE 1183



 Score = 31.6 bits (70), Expect = 6.3
 Identities = 63/263 (23%), Positives = 83/263 (31%), Gaps = 57/263 (21%)

Query: 90   GPSPMLLPEGLSSQALSTEAPLPATLEPRIVMGEETCQALLSPRAARTALRDQEGGHASP 149
            GP P+  P G    A  T  P+P  L   +++        L P              AS 
Sbjct: 1020 GPVPVRPPPGPELSAQPTPGPVPQVLPASLMVSASPAGPPLIP--------------ASR 1065

Query: 150  DPPPEL---CSQGDLSVPSPPPDPDSFFTPPSTPTKTTYALLPACGPHGDARDSEAELRD 206
             P P L         S+P   P P    +  S P   T +L P   P    R S      
Sbjct: 1066 PPGPVLLPPLQPNSGSLPQVLPSPLGVLSGTSRPPTPTLSLKPT--PPAPVRLS------ 1117

Query: 207  ELLDSPPASPSGSYITADGDSWASSPSCSLSLLAPAEGLDFPSGWGLSPQGSMVDERELH 266
                  PA P G                S SLL P   L  P G+   P  +        
Sbjct: 1118 ------PAPPPG----------------SSSLLKP---LTVPPGYTFPPAAATTTSTTTA 1152

Query: 267  PAGT-----PEPPSSESSLSADSSSSWGQEGHFFDLDFLANDPMIPAALLPFQGSLIFQV 321
             A T     P P      LS D  +     G    +  LA+    P A       L FQ+
Sbjct: 1153 TATTTAVPAPTPAPQRLILSPDMQARL-PSGEVVSIGQLASLAQRPVANAGGSKPLTFQI 1211

Query: 322  EAVEVTPLSPEEEEEEAVADPDP 344
            +  ++T L+  +  + AV  P P
Sbjct: 1212 QGNKLT-LTGAQVRQLAVGQPRP 1233


>gi|167736355 mucin 4 isoform a [Homo sapiens]
          Length = 5284

 Score = 89.4 bits (220), Expect = 3e-17
 Identities = 283/1259 (22%), Positives = 398/1259 (31%), Gaps = 208/1259 (16%)

Query: 90   GPSPMLLPEGLSSQALSTEAPLPATLEPRIVMGEETCQALLSPRAARTALRDQEGGHASP 149
            G +  LL    SS +     PLP T       G  T   + SP +A T       GHA+P
Sbjct: 1468 GQATSLLVTDTSSVSTGDTTPLPVTSTSSASTGHVTPLHVTSPSSAST-------GHATP 1520

Query: 150  DPPPEL--CSQGDLSVPSPPPDPDSFFTPPSTPTKTTYALLPACGPHGDARDSEAELRDE 207
             P   L   S GD ++P P   P S  T  +TP   T           DA          
Sbjct: 1521 LPVTSLSSASTGD-TMPLPVTSPSSASTGDTTPLPVT-----------DASSVSTGHTTP 1568

Query: 208  LLDSPPASPSGSYIT----ADGDSWASSPSCSLSLLAPAEGLDFPSGWGLSPQGSMVDER 263
            L  + P+S S  + T     D  S +   +  L + +P+      +  G +    + D  
Sbjct: 1569 LPVTSPSSASTGHTTPLPVTDTSSASKGDTTPLPVTSPSS-----ASTGHTTPLPVTDTS 1623

Query: 264  ELHPAG-TPEPPSSESSLSAD-------SSSSWGQEGHFFDLDFLANDPMIP--AALLPF 313
                   TP P ++ SSLS         +S S    GH   L   +        A  LP 
Sbjct: 1624 SASTGDTTPLPVTNASSLSTGHATPLHVTSPSSASTGHATPLPVTSTSSASTGHATPLPV 1683

Query: 314  QGSLIFQVEAVEVTPLSPEEEEEEAVADPDPGGDLAGEGEEDSTSASFLQSLSDLSITEG 373
             G      +     P++         A P P   L+     D+T    L   S  S + G
Sbjct: 1684 TGLSSATTDDTTRLPVTDVSSASTGQATPLPVTSLSSVSTGDTTP---LPVTSPSSASTG 1740

Query: 374  MDEAFAFRDDTSAASSDSDSASYAEADDERLYSGEPHAQATLLQDSVQKTEEESGGGAKG 433
                    D +SA++  +      +          P     L   S   T          
Sbjct: 1741 HASPLLVTDASSASTGQATPLPVTDTSSVSTAHATPLPVTGLSSASTDDTTR-------- 1792

Query: 434  LQAQDGTVSWAVEAAPQTSDRGAYLSQRQELISEVTEEGLALGQESTATVTPHTLQVAPG 493
            L   D + +   +A P      +  S        VT+   A   ++T+         + G
Sbjct: 1793 LPVTDVSSASTGQAIPLPVTSPSSASTGDTTPLPVTDASSASTGDTTSLPVTIPSSASSG 1852

Query: 494  ----LQVEVATRVTPQAGEEETDSTAGQESAAMAMPQPSQEGISEILGQES---VTAEKL 546
                L V  A+ V+         + A   S     P P  +  S   G  +   VT    
Sbjct: 1853 HTTSLPVTDASSVSTGHATSLLVTDASSVSTGDTTPLPVTDTNSASTGDTTPLHVTDASS 1912

Query: 547  PTPQEETSLTLCPDSPQNLKEEGGLDLPSGRK---------PVAAATIVPRQAKEDLTLP 597
             +    TSL +   S  +  +   L + S            PV  A+ VP      L + 
Sbjct: 1913 VSTGHATSLPVTSLSSASTGDTTPLPVTSPSSASSGHTTPLPVTDASSVPTGHATSLPVT 1972

Query: 598  QDSAMT----PPLPLQDTDLSS----APKPVAAATIVSQQAEEGLTLPQDSVM------T 643
              S+++     PLP+ D    S     P PV   + VS    +   LP  S+       T
Sbjct: 1973 DASSVSTGHATPLPVTDASSVSTGHATPLPVTDTSSVS--TGQATPLPVTSLSSASTGDT 2030

Query: 644  PPLPLQDTELSS----APKPVAAATLVSQQAEEGL--TLPQDSAMTPPLPLQDTDLSSAP 697
             PLP+ DT  +S     P PV + + VS      L  T P  ++     PL  TD SS  
Sbjct: 2031 TPLPVTDTSSASTGQDTPLPVTSLSSVSTGDTTPLPVTSPSSASTGHATPLLVTDASSVS 2090

Query: 698  KPVAAATLVSQQAEEG------------------------LTLPQDSAM--TPPLPLQDT 731
               A + LV+  +                           +T P  ++   T PLP+ DT
Sbjct: 2091 TGHATSLLVTDASSVSTGHATALHVTDASSLSTGDTTPLPVTSPSSASTGDTTPLPVTDT 2150

Query: 732  DLSSAPKPVAAATLVSQQAEEG--LTLP---QDSAMT---PPLPLQDTDLSSAPKPVAAA 783
               S     +     +  A  G   +LP     SA T    PLP+ DT  +S  +     
Sbjct: 2151 SSVSTGHATSLPVTDTSSASTGHATSLPVTDTSSASTGHATPLPVTDTSSASTGQATPLP 2210

Query: 784  TIVSQQAEEGLTLP-----QDSAMT-PPLPLQDTDLSSA------PKPVAAATIVSQQAE 831
                  A  G  +P       SA T    PL  T LSSA      P PV  A+ VS    
Sbjct: 2211 VTSPSSASTGHAIPLLVTDTSSASTGQATPLPVTSLSSASTGDTTPLPVTDASSVSTGHA 2270

Query: 832  EGL------------------TLPQDSAMTPPLPLQDTDLSSAPKPVAAATPVSQQAEEG 873
              L                  T P  ++     PL  TD SSA    A   PV+  +   
Sbjct: 2271 TSLPVTSLSSVSTGDTTPLPVTSPSSASTGHATPLHVTDASSASTGHATPLPVTSLSSAS 2330

Query: 874  --------LTLPQDSAMTPPLPLQDTDLSSAPKPVAAATPV--SQQAEEGLTLP------ 917
                    +T P  ++     PL  TD SS         PV  S  A  G T P      
Sbjct: 2331 TGDTTPLPVTSPSSASTGHATPLHVTDASSVSTGDTTPLPVTSSSSASSGHTTPLPVTDA 2390

Query: 918  --QDSAMTAPLPLQDTGPTSGPEPLAVATPQTLQAEAGCAPGTE-PVATMAQQEVGEALG 974
                +  T PLP+ DT   S     A   P T  + A     T  PV  ++    G A  
Sbjct: 2391 SSASTGDTTPLPVTDTSSASTGH--ATHLPVTGLSSASTGDTTRLPVTNVSSASTGHAT- 2447

Query: 975  PRPAPEEKNAAL-PTVPEPAALDQVQQDDPQPAAEAGTPWAAQEDADSTLGMEALSLPEP 1033
            P P     +A+   T P P         D    +   T      DA S    +   LP  
Sbjct: 2448 PLPVTSTSSASTGDTTPLPGT-------DTSSVSTGHTTPLLVTDASSVSTGDTTRLPVT 2500

Query: 1034 ASGAGEEIAEALSRPGREACLEARAHTGDGAKPDSPQKET-----LEVENQQEGGLKPLA 1088
            +  +                  +  HT      D+P   T     L V N      +   
Sbjct: 2501 SPSSA-----------------STGHTTPLPVTDTPSASTGDTTPLPVTNASSLSTRHAT 2543

Query: 1089 QEH--GPRSALGGAREVPDAPPAACPEVSQARLLSPAREERGLSGKSTPEPTLPSAVATE 1146
              H   P SA  G          +      A  L         +G +TP P   +  A+ 
Sbjct: 2544 SLHVTSPSSASTGHATSLPVTDTSAASTGHATPLPVTSTSSASTGDTTPLPVTDTYSAST 2603

Query: 1147 ASLDSCPESSVGAVSSLDRGCPDAPAPTSAPTSQ-QPEPVLGLGSVEQPHEVPSVLGTP 1204
                  P +   + S+ D         +SA T    P PV    SV   H  P  + +P
Sbjct: 2604 GQATPLPVTDTSSASTGDTTPLPVTDTSSASTGHATPLPVTNTSSVSTGHATPLHVTSP 2662



 Score = 82.4 bits (202), Expect = 3e-15
 Identities = 274/1261 (21%), Positives = 404/1261 (32%), Gaps = 215/1261 (17%)

Query: 84   ADPGEGGPSPMLLPEGLSSQALSTEAPLPATLEPRIVMGEETCQALLSPRAARTALRDQE 143
            A  G+  P P+     LSS +     PLP T       G  T   +    +A T      
Sbjct: 2793 ASTGQATPLPVT---SLSSVSTGDTTPLPVTDTSSASTGHATSLPVTDTSSAST------ 2843

Query: 144  GGHASPDPPPELCSQG----------DLSVPS-------PPPDPDSFFTPPSTPTKTTYA 186
             GHA+P P  +  S            D S  S       P  D  S  T  +TP   T  
Sbjct: 2844 -GHATPLPDTDTSSASTGHATLLPVTDTSSASIGHATSLPVTDTSSISTGHATPLHVTSP 2902

Query: 187  LLPACG-----PHGDARDSEAELRDELLDSPPASPSGSYITADGDSWASSPSCSLSLLAP 241
               + G     P  D   +     + L  + P+S S  + T    +  SS S   +   P
Sbjct: 2903 SSASTGHATPLPVTDTSSASTGHANPLHVTSPSSASTGHATPLPVTDTSSASTGHATPLP 2962

Query: 242  AEGLDFPSGWGLSPQGSMVDERELHPAGTPEPPSSESSLSAD-------SSSSWGQEGHF 294
               L   S    +P              TP P +  SS S         +S+S    G  
Sbjct: 2963 VTSLSSVSTGDTTPLPVTSPSSASTGHTTPLPVTDTSSASTGQATALPVTSTSSASTGDT 3022

Query: 295  FDLDFLANDPMIPAALLPFQGSLIFQVEAVEVTPLSPEEEEEEAVADPDP----GGDLAG 350
              L              P   + +  V   + TPL        +     P        A 
Sbjct: 3023 TPLPVTDTSSASTGQATPLPVTSLSSVSTGDTTPLPVTSPSSASTGHATPLLVTDASSAS 3082

Query: 351  EGEEDSTSASFLQSLSD-----LSITEGMDEAFAFRD-----DTSAASSDSDSASYAEAD 400
             G+      + L S+S      L +T     +          DTS+AS+  D+ S    D
Sbjct: 3083 TGQATPLPVTSLSSVSTGDTTPLPVTSPSSASTGHATSLPVTDTSSAST-GDTTSLPVTD 3141

Query: 401  DERLYSGEPHAQATLLQDSVQKTEEESGGGAKGLQAQDGTVSWAVEAAPQTSDRGAYLSQ 460
                Y+G+  +        V  T   S G    L   + +      A P      +  S 
Sbjct: 3142 TSSAYTGDTTSLP------VTDTSSSSTGDTTPLLVTETSSVSTGHATPLLVTDASSAST 3195

Query: 461  RQELISEVTEEGLALGQESTATVTPHTLQVAPGLQVEVATRVTPQAGEEET------DST 514
                   VT    A   ++T      T  V+ G    +       A   +T      D +
Sbjct: 3196 GHATPLHVTSPSSASTGDTTPVPVTDTSSVSTGHATPLPVTGLSSASTGDTTRLPVTDIS 3255

Query: 515  AGQESAAMAMPQPSQEGISEILGQESVTAEKLPTPQEETSLTLCPDSPQNLKEEGGLDLP 574
            +     A  +P  +   +S        T + +P P           SP +        LP
Sbjct: 3256 SASTGQATPLPVTNTSSVS--------TGDTMPLPVT---------SPSSASTGHATPLP 3298

Query: 575  SGRKPVAA---ATIVPRQAKEDLTLPQDSAMTPPLPLQDTDLSSA----PKPVAAATIVS 627
                  A+   AT VP  +    T    +  T PLP+ DT  +S     P PV + +  S
Sbjct: 3299 VTSTSSASTGHATPVPVTS----TSSASTGHTTPLPVTDTSSASTGDTTPLPVTSPSSAS 3354

Query: 628  QQAEEGL--TLPQDSVMTPPLPLQDTELSSA------PKPVAAATLVSQQAEEGLTLPQD 679
                  L  T+P  +       L  T  SSA      P PV   + VS      L +   
Sbjct: 3355 TGHTTPLHVTIPSSASTGDTSTLPVTGASSASTGHATPLPVTDTSSVSTGHATPLPVTSL 3414

Query: 680  SAM----TPPLPLQDTDLSSA----PKPVAAATLVSQQAEEGLTLPQDSAMTP----PLP 727
            S++    T PLP+ D   +S     P PV + + VS      L +   S+++     PLP
Sbjct: 3415 SSVSTGDTTPLPVTDASSASTGQATPLPVTSLSSVSTGDTTPLLVTDASSVSTGHATPLP 3474

Query: 728  LQDT--------------DLSSA------PKPVAAATLVSQQAEEGLTLPQDSAMTP--- 764
            + DT              D SSA      P PV + + VS      L +   S+++    
Sbjct: 3475 VTDTSSASTGDTTRLPVTDTSSASTGQATPLPVTSLSSVSTGDTTPLLVTDASSVSTGHA 3534

Query: 765  -PLPLQDT------DLSSAPKPVAAATIVSQQAEEGLTLPQDSAM--TPPLPLQDTDLSS 815
             PLP+ DT      D +  P    ++    Q     +T+P  S+   T PLP+  T   S
Sbjct: 3535 TPLPVTDTSSASTGDTTRLPVTDTSSASTGQATPLPVTIPSSSSSGHTTPLPVTSTSSVS 3594

Query: 816  A--------------------PKPVAAATIVSQQAEEGLTLPQDSAMTP--PLPLQDTDL 853
                                 P PV + +  S      L +   S+++     PL  TD 
Sbjct: 3595 TGHVTPLHVTSPSSASTGHVTPLPVTSTSSASTGHATPLLVTDASSVSTGHATPLPVTDA 3654

Query: 854  SSA------PKPVAAATPVSQQAEEGLTLPQDSAM----TPPLPLQDTDLSSAPKPVAAA 903
            SSA      P PV   +  S      L +   S++    T PLP+  TD SSA    A  
Sbjct: 3655 SSASTGDTTPLPVTDTSSASTGQATPLPVTSLSSVSTGDTTPLPV--TDASSASTGHATP 3712

Query: 904  TPVSQQAEEGLTLPQDSAMTAPLPLQDTGPTSGPEPLAVATPQTLQAEAGCAPGTEPVAT 963
             PV        T+P   +    +PL  T P+S     A   P T  + A     T    T
Sbjct: 3713 LPV--------TIPSSVSTGDTMPLPVTSPSSASTGHATPLPVTGLSSASTGDTTPLPVT 3764

Query: 964  MAQQEVGEALGPRPAPEEKNAALPTVPEPAALDQVQQDDPQPAAEAGTPWAAQEDADSTL 1023
                       P P  +  +A+          D              T  ++    D+T 
Sbjct: 3765 DTSSASTRHATPLPVTDTSSASTDDTTRLPVTDVSSASTGHATPLPVTSTSSASTGDTT- 3823

Query: 1024 GMEALSLPEPASGAGE-EIAEALSRPGREACLEARAHTGDGAKPDSPQKETLEVENQQEG 1082
                   P P +         A S P     + +R+    G     P  +T  V     G
Sbjct: 3824 -------PLPVTDTSSVSTGHATSLP-----VTSRSSASTGHATPLPVTDTSSVST---G 3868

Query: 1083 GLKPLAQEHGPRSALGGAREVPDAPPAACPEVSQARLLSPAREERGLSGKSTPEP----- 1137
               PL        + G A  +P   P++      A  +         +G +TP P     
Sbjct: 3869 HATPLPVTSTSSVSTGHATPLPVTSPSSA-STGHATPVPVTSTSSASTGDTTPLPVTNAS 3927

Query: 1138 TLPSAVATEASLDSCPESSVGAVSSLDRGCPDAPAPTSAPTSQQPEPVLGLGSVEQPHEV 1197
            +L +  AT   + S   +S G  S+L    P   A +++     P P+  L SV      
Sbjct: 3928 SLSTGHATPLHVTSPSSASRGDTSTL----PVTDASSASTGHATPLPLTSLSSVSTGDTT 3983

Query: 1198 P 1198
            P
Sbjct: 3984 P 3984



 Score = 79.7 bits (195), Expect = 2e-14
 Identities = 215/935 (22%), Positives = 311/935 (33%), Gaps = 158/935 (16%)

Query: 594  LTLPQDSAM--TPPLPLQDTDLSSAPKPVAAATIVSQQAEEGLTLPQDSVMTPPL----- 646
            +T+P  ++   T PLP+ DT  +S  +  +     +     G T P     T        
Sbjct: 1235 VTIPSAASTGHTTPLPVTDTSSASTGQATSLLVTDTSSVSTGDTTPLPVTSTSSASTGHV 1294

Query: 647  -PLQDTELSSAPK----PVAAATLVSQQAEEGLTLPQDSAM------TPPLPLQD----- 690
             PL  T  SSA      P+   +L S    + + LP  S        T PLP+ D     
Sbjct: 1295 TPLHVTSPSSASTGHATPLPVTSLSSASTGDTMPLPVTSPSSASTGDTTPLPVTDASSVS 1354

Query: 691  ---------TDLSSA------PKPVAAATLVSQQAEEGL--TLPQDSAMTPPLPLQDTDL 733
                     TD SSA      P PV + + VS      L  T P  ++     PL  TD 
Sbjct: 1355 TGHTTPLHVTDASSASTGQATPLPVTSLSSVSTGDTTPLPVTSPSSASTGHATPLLVTDT 1414

Query: 734  SSA------PKPVAAATLVSQQAEEGL--TLPQDSAMTPPLPLQDTDLSSAPKPVAAATI 785
            SSA      P PV  A+ VS      L  T+P  ++     PL  TD SSA    A + +
Sbjct: 1415 SSASTGHATPLPVTDASSVSTDHATSLPVTIPSAASTGHTTPLPVTDTSSASTGQATSLL 1474

Query: 786  VSQQAEEGLTLPQDSAMTPPLPLQDTDLSSAPK--PVAAATIVSQQAEEGLTLPQDSAM- 842
            V+       T    +  T PLP+  T  +S     P+   +  S        LP  S   
Sbjct: 1475 VTD------TSSVSTGDTTPLPVTSTSSASTGHVTPLHVTSPSSASTGHATPLPVTSLSS 1528

Query: 843  -----TPPLPLQDTDLSSA----PKPVAAATPVSQQAEEGL--TLPQDSAMTPPLPLQDT 891
                 T PLP+     +S     P PV  A+ VS      L  T P  ++     PL  T
Sbjct: 1529 ASTGDTMPLPVTSPSSASTGDTTPLPVTDASSVSTGHTTPLPVTSPSSASTGHTTPLPVT 1588

Query: 892  DLSSAPKPVAAATPVSQQAEEGLTLPQDSAMTAPLPLQDT--GPTSGPEPLAV------- 942
            D SSA K      PV+  +         +  T PLP+ DT    T    PL V       
Sbjct: 1589 DTSSASKGDTTPLPVTSPSS------ASTGHTTPLPVTDTSSASTGDTTPLPVTNASSLS 1642

Query: 943  ---ATPQTLQAEAGCAPGTE---PVATMAQQEVGEA-----LGPRPAPEEKNAALPTVPE 991
               ATP  + + +  + G     PV + +    G A      G   A  +    LP    
Sbjct: 1643 TGHATPLHVTSPSSASTGHATPLPVTSTSSASTGHATPLPVTGLSSATTDDTTRLPVTDV 1702

Query: 992  PAALDQVQQDDPQPAAEAG-------TPWAAQEDADSTLGMEALSLPEPASGAGEEIAEA 1044
             +A     Q  P P            TP      + ++ G  +  L   AS A     +A
Sbjct: 1703 SSA--STGQATPLPVTSLSSVSTGDTTPLPVTSPSSASTGHASPLLVTDASSA--STGQA 1758

Query: 1045 LSRPGREACLEARAHT--------GDGAKPDSPQKETLEVENQQEGGLKPLAQEHGPRSA 1096
               P  +    + AH            +  D+ +    +V +   G   PL       ++
Sbjct: 1759 TPLPVTDTSSVSTAHATPLPVTGLSSASTDDTTRLPVTDVSSASTGQAIPLPVTSPSSAS 1818

Query: 1097 LGGAREVP--DAPPAACPEVSQARLLSPAREERGLSGKSTPEPTLPSAVATEASLDSCPE 1154
             G    +P  DA  A+  + +   +  P+      SG +T  P   ++  +     S   
Sbjct: 1819 TGDTTPLPVTDASSASTGDTTSLPVTIPSSAS---SGHTTSLPVTDASSVSTGHATSLLV 1875

Query: 1155 SSVGAVSSLDRGCPDAPAPTSAPTSQ-QPEPVLGLGSVEQPH----EVPSVLG------T 1203
            +   +VS+ D          SA T    P  V    SV   H     V S+        T
Sbjct: 1876 TDASSVSTGDTTPLPVTDTNSASTGDTTPLHVTDASSVSTGHATSLPVTSLSSASTGDTT 1935

Query: 1204 PLLQPPENLAKGQPSTPV------DRPLGPDPSAPGTLAGAALPPLEPPAPCLCQDPQED 1257
            PL     + A    +TP+        P G   S P T A +       P P    D    
Sbjct: 1936 PLPVTSPSSASSGHTTPLPVTDASSVPTGHATSLPVTDASSVSTGHATPLP--VTDASSV 1993

Query: 1258 SVEDEEP-------PGSLGLPPPQAGVQPAAAAVSGTTQ-PLGTGPRVSLSPHSPLLSPK 1309
            S     P         S G   P      ++A+   TT  P+      S    +PL    
Sbjct: 1994 STGHATPLPVTDTSSVSTGQATPLPVTSLSSASTGDTTPLPVTDTSSASTGQDTPLPVTS 2053

Query: 1310 VASMDAKDLALQILPPCQVPPPSGPQSPAGPQGLSAPEQQEDEDSLEEDSPRAL---GSG 1366
            ++S+   D       P  V  PS   +     G + P    D  S+      +L    + 
Sbjct: 2054 LSSVSTGDTT-----PLPVTSPSSAST-----GHATPLLVTDASSVSTGHATSLLVTDAS 2103

Query: 1367 QHSDSHGESSAELDEQDILAPQTVQCPAQAPAGGS 1401
              S  H  +    D   +    T   P  +P+  S
Sbjct: 2104 SVSTGHATALHVTDASSLSTGDTTPLPVTSPSSAS 2138



 Score = 78.2 bits (191), Expect = 6e-14
 Identities = 301/1371 (21%), Positives = 433/1371 (31%), Gaps = 183/1371 (13%)

Query: 90   GPSPMLLPEGLSSQALSTEAPLPATLEPRIVMGEETCQALLSPRAARTALRDQEGGHASP 149
            G +  LL    SS +     PLP T       G  T   + SP +A T       GHA+P
Sbjct: 1260 GQATSLLVTDTSSVSTGDTTPLPVTSTSSASTGHVTPLHVTSPSSAST-------GHATP 1312

Query: 150  DPPPEL--CSQGDLSVPSPPPDPDSFFTPPSTPTKTTYALLPACGPHGDARDSEAELRDE 207
             P   L   S GD ++P P   P S  T  +TP   T A   + G       ++A     
Sbjct: 1313 LPVTSLSSASTGD-TMPLPVTSPSSASTGDTTPLPVTDASSVSTGHTTPLHVTDASSAST 1371

Query: 208  LLDSP-PASPSGSYITADGDSWASSPSCSLSLLAPAEGLDFPSGWGLSPQGSMVDERELH 266
               +P P +   S  T D     ++P    S  + + G   P          +V +    
Sbjct: 1372 GQATPLPVTSLSSVSTGD-----TTPLPVTSPSSASTGHATP---------LLVTDTSSA 1417

Query: 267  PAG--TPEPPSSESSLSADSSSSW-------GQEGHFFDLDFLANDPMIPAALLPFQGSL 317
              G  TP P +  SS+S D ++S           GH   L                  + 
Sbjct: 1418 STGHATPLPVTDASSVSTDHATSLPVTIPSAASTGHTTPLPVTDTSSASTGQATSLLVTD 1477

Query: 318  IFQVEAVEVTPLSPEEEEEEAVADPDPGGDLAGEGEEDSTSASFLQSLSDLSITEGMDEA 377
               V   + TPL        +     P   +       +  A+ L   S  S + G    
Sbjct: 1478 TSSVSTGDTTPLPVTSTSSASTGHVTP-LHVTSPSSASTGHATPLPVTSLSSASTGDTMP 1536

Query: 378  FAFRDDTSAASSD------SDSASYAEADDERLYSGEPHAQATLLQDSVQKTEEESGGGA 431
                  +SA++ D      +D++S +      L    P + +T     +  T+  S   +
Sbjct: 1537 LPVTSPSSASTGDTTPLPVTDASSVSTGHTTPLPVTSPSSASTGHTTPLPVTDTSS--AS 1594

Query: 432  KGLQAQDGTVSWAVEAAPQTSDRGAYLSQRQELISEVTEEGLALGQESTATVTPHTLQVA 491
            KG    D T        P TS   A       L   VT+   A    ST   TP  +  A
Sbjct: 1595 KG----DTT------PLPVTSPSSASTGHTTPL--PVTDTSSA----STGDTTPLPVTNA 1638

Query: 492  PGLQVEVATRVTPQAGEEETDSTAGQESAAMAMPQPSQEGISEILGQES---VTAEKLPT 548
              L    AT +          ++    S   A P P     S   G  +   VT     T
Sbjct: 1639 SSLSTGHATPLHV--------TSPSSASTGHATPLPVTSTSSASTGHATPLPVTGLSSAT 1690

Query: 549  PQEETSLTLCPDSPQNLKEEGGLDLPSGRKPVAAATIVPRQAKEDLTLPQDSAMTPPLPL 608
              + T L +   S  +  +   L + S    V+     P      +T P  ++     PL
Sbjct: 1691 TDDTTRLPVTDVSSASTGQATPLPVTS-LSSVSTGDTTPL----PVTSPSSASTGHASPL 1745

Query: 609  QDTDLSSAPKPVAAATIVSQQAEEGLTLPQDSVMTPPLPLQDTELSSAPKPVAAATLVSQ 668
              TD SSA    A    V+       T    +    PLP+     +S             
Sbjct: 1746 LVTDASSASTGQATPLPVTD------TSSVSTAHATPLPVTGLSSASTDDTTRLPVTDVS 1799

Query: 669  QAEEGLTLPQDSAMTPPLPLQDTDLSSAPKPVAAATLVSQQAEEGLTLPQDSAMTPPLPL 728
             A  G  +P    +T P      D +  P   A++          +T+P  ++      L
Sbjct: 1800 SASTGQAIP--LPVTSPSSASTGDTTPLPVTDASSASTGDTTSLPVTIPSSASSGHTTSL 1857

Query: 729  QDTDLSSAPKPVAAATLVSQQAEEGLTLPQDSAMTPPLPLQDTDLSS----APKPVAAAT 784
              TD SS     A + LV+  +         +  T PLP+ DT+ +S     P  V  A+
Sbjct: 1858 PVTDASSVSTGHATSLLVTDASS------VSTGDTTPLPVTDTNSASTGDTTPLHVTDAS 1911

Query: 785  IVS------------QQAEEGLTLP--------QDSAMTPPLPLQDTDLSSAPK------ 818
             VS              A  G T P          S  T PLP+  TD SS P       
Sbjct: 1912 SVSTGHATSLPVTSLSSASTGDTTPLPVTSPSSASSGHTTPLPV--TDASSVPTGHATSL 1969

Query: 819  PVAAATIVSQQAEEGLTLPQDSAMTP--PLPLQDTDLSSAPKPVAAATPVSQQAEEGLTL 876
            PV  A+ VS      L +   S+++     PL  TD SS     A   PV+  +      
Sbjct: 1970 PVTDASSVSTGHATPLPVTDASSVSTGHATPLPVTDTSSVSTGQATPLPVTSLSS----- 2024

Query: 877  PQDSAMTPPLPLQDTDLSS----APKPVAAATPVSQQAEEGLTLPQDSAMTAPLPLQDTG 932
               +  T PLP+ DT  +S     P PV + + VS            +  T PLP+  T 
Sbjct: 2025 -ASTGDTTPLPVTDTSSASTGQDTPLPVTSLSSVS------------TGDTTPLPV--TS 2069

Query: 933  PTSGPEPLAVATPQTLQAEAGCAPGTEPVATMAQQ-EVGEALGPRPAPEEKNAALPTVPE 991
            P+S     A     T  +       T  + T A     G A           +   T P 
Sbjct: 2070 PSSASTGHATPLLVTDASSVSTGHATSLLVTDASSVSTGHATALHVTDASSLSTGDTTPL 2129

Query: 992  PAALDQVQQDDPQPAAEAGTPWAAQEDADSTLGMEALSLPEPASGAGEEIAEALSRPGRE 1051
            P          P  A+   T      D  S     A SLP   + +      A S P  +
Sbjct: 2130 PVT-------SPSSASTGDTTPLPVTDTSSVSTGHATSLPVTDTSSA-STGHATSLPVTD 2181

Query: 1052 ACLEARAHTGDGAKPDSPQKETLEVENQQEGGLKPLAQEHGPRSALGGAREVPDAPPAAC 1111
                +  H       D+    T        G   PL     P SA  G          + 
Sbjct: 2182 TSSASTGHATPLPVTDTSSAST--------GQATPLPVT-SPSSASTGHAIPLLVTDTSS 2232

Query: 1112 PEVSQARLLSPAREERGLSGKSTPEPTLPSAVATEASLDSCPESSVGAVSSLDRGCPDAP 1171
                QA  L         +G +TP P   ++  +     S P +S+ +VS+ D       
Sbjct: 2233 ASTGQATPLPVTSLSSASTGDTTPLPVTDASSVSTGHATSLPVTSLSSVSTGDTTPLPVT 2292

Query: 1172 APTSAPTSQ-QPEPVLGLGSVEQPHEVPSVLGTPLLQPPENLAKGQPSTPVDRPLGPDPS 1230
            +P+SA T    P  V    S    H       TPL     + A    +TP+     P  S
Sbjct: 2293 SPSSASTGHATPLHVTDASSASTGH------ATPLPVTSLSSASTGDTTPL-----PVTS 2341

Query: 1231 APGTLAGAALPPLEPPAPCLCQDPQEDSVEDEEPPGSLGLPPPQAGVQPAAAAVSGTTQP 1290
                  G A P     A  +                S G   P   V  A++A +G T P
Sbjct: 2342 PSSASTGHATPLHVTDASSVSTGDTTPLPVTSSSSASSGHTTP-LPVTDASSASTGDTTP 2400

Query: 1291 LGTGPRVSLSPHSPLLSPKVASMDAKDLALQILPPCQVPPPSGPQSPAGPQGLSAPEQQE 1350
            L      S S       P      A       LP   V   S   +   P   ++     
Sbjct: 2401 LPVTDTSSASTGHATHLPVTGLSSASTGDTTRLPVTNVSSASTGHATPLPVTSTSSASTG 2460

Query: 1351 DEDSLEEDSPRALGSGQHSDSHGESSAELDEQDILAPQTVQCPAQAPAGGS 1401
            D   L      ++ +G     H       D   +    T + P  +P+  S
Sbjct: 2461 DTTPLPGTDTSSVSTG-----HTTPLLVTDASSVSTGDTTRLPVTSPSSAS 2506



 Score = 76.3 bits (186), Expect = 2e-13
 Identities = 161/700 (23%), Positives = 238/700 (34%), Gaps = 149/700 (21%)

Query: 603  TPPLPLQDTDLSSA----PKPVAAATIVSQQAEEGLTLPQDSVM----TPPLPLQDTELS 654
            T PLP  DT   S     P  V  A+ VS      L +   S      T PLP+ DT  +
Sbjct: 2462 TTPLPGTDTSSVSTGHTTPLLVTDASSVSTGDTTRLPVTSPSSASTGHTTPLPVTDTPSA 2521

Query: 655  SA----PKPVAAATLVSQQAEEGLTLPQDSAMTP----PLPLQDTDLSSA----PKPVAA 702
            S     P PV  A+ +S +    L +   S+ +      LP+ DT  +S     P PV +
Sbjct: 2522 STGDTTPLPVTNASSLSTRHATSLHVTSPSSASTGHATSLPVTDTSAASTGHATPLPVTS 2581

Query: 703  ATLVSQQAEEGLTLPQDSAMTPPLPLQDTDLSSAPKPVAAATLVSQQAEEGLTLPQDSAM 762
             +  S            +  T PLP+ DT  +S  +        +  A  G         
Sbjct: 2582 TSSAS------------TGDTTPLPVTDTYSASTGQATPLPVTDTSSASTG--------D 2621

Query: 763  TPPLPLQDTDLSSA----PKPVAAATIVSQQAEEGLTLPQDSAM----TPPLPLQDTD-- 812
            T PLP+ DT  +S     P PV   + VS      L +   S+     T PLP+ D    
Sbjct: 2622 TTPLPVTDTSSASTGHATPLPVTNTSSVSTGHATPLHVTSPSSASTGHTTPLPVTDASSV 2681

Query: 813  ----LSSAPKPVAAATIVSQQAEEGLTLPQDSAMTPPLPLQDTDLSS------------- 855
                 +S P   A++          +T+P  ++     PL  TD SS             
Sbjct: 2682 STGHATSLPVTDASSVFTGHATSLPVTIPSSASSGHTTPLPVTDASSVSTGHATSLPVTD 2741

Query: 856  ---------APKPVAAATPVSQQAEEGLTLPQDSAM----TPPLPLQDTDLSS----APK 898
                      P PV  A+ VS      L L   S++    T PLP+ DT  +S     P 
Sbjct: 2742 ASSVSTGHATPLPVTDASSVSTGHATPLPLTSLSSVSTGDTTPLPVTDTSSASTGQATPL 2801

Query: 899  PVAAATPVSQQAEEGLTLPQDSAMTAPLPLQDTGPTSGPEPLAVATPQTLQAEAGCA--- 955
            PV + + VS            +  T PLP+ DT   S     ++    T  A  G A   
Sbjct: 2802 PVTSLSSVS------------TGDTTPLPVTDTSSASTGHATSLPVTDTSSASTGHATPL 2849

Query: 956  PGTE------------PVATMAQQEVGEALGPRPAPEEKNAALPTVPEPAALDQVQQDDP 1003
            P T+            PV   +   +G A      P    +++ T         +    P
Sbjct: 2850 PDTDTSSASTGHATLLPVTDTSSASIGHATS---LPVTDTSSIST----GHATPLHVTSP 2902

Query: 1004 QPAAEA-GTPWAAQEDADSTLG-MEALSLPEPASGAGEEIAEALSRPGREACLEARAHTG 1061
              A+    TP    + + ++ G    L +  P+S +      A   P  +    +  H  
Sbjct: 2903 SSASTGHATPLPVTDTSSASTGHANPLHVTSPSSAS---TGHATPLPVTDTSSASTGHA- 2958

Query: 1062 DGAKPDSPQKETLEVENQQEGGLKPLAQEHGPRSALGGAREVPDAPPAACPEVSQARLLS 1121
                  +P   T  + +   G   PL     P SA  G          +     QA  L 
Sbjct: 2959 ------TPLPVT-SLSSVSTGDTTPLPVT-SPSSASTGHTTPLPVTDTSSASTGQATALP 3010

Query: 1122 PAREERGLSGKSTPEPTLPSAVATEASLDSCPESSVGAVSSLDRGCPDAPAPTSAPTSQ- 1180
                    +G +TP P   ++ A+       P +S+ +VS+ D       +P+SA T   
Sbjct: 3011 VTSTSSASTGDTTPLPVTDTSSASTGQATPLPVTSLSSVSTGDTTPLPVTSPSSASTGHA 3070

Query: 1181 ----------------QPEPVLGLGSVEQPHEVPSVLGTP 1204
                             P PV  L SV      P  + +P
Sbjct: 3071 TPLLVTDASSASTGQATPLPVTSLSSVSTGDTTPLPVTSP 3110



 Score = 75.1 bits (183), Expect = 5e-13
 Identities = 233/1063 (21%), Positives = 344/1063 (32%), Gaps = 150/1063 (14%)

Query: 25   SCDAAAATTILGGDRREPCALTPGPSHLALTFLPSKPGARPQPEGASWDAGPGGA---PS 81
            S     AT +L  D          P H+      S     P P   +     G A   P 
Sbjct: 3176 SVSTGHATPLLVTDASSASTGHATPLHVTSPSSASTGDTTPVPVTDTSSVSTGHATPLPV 3235

Query: 82   AWADPGEGGPSPMLLPEGLSSQALSTEAPLPATLEPRIVMGEETCQALLSPRAARTALRD 141
                    G +  L    +SS +     PLP T    +  G+     + SP +A T    
Sbjct: 3236 TGLSSASTGDTTRLPVTDISSASTGQATPLPVTNTSSVSTGDTMPLPVTSPSSAST---- 3291

Query: 142  QEGGHASPDPPPELCSQGD-LSVPSPPPDPDSFFTPPSTPTKTTYALLPACGPHGDARDS 200
               GHA+P P     S     + P P     S  T  +TP   T           D   +
Sbjct: 3292 ---GHATPLPVTSTSSASTGHATPVPVTSTSSASTGHTTPLPVT-----------DTSSA 3337

Query: 201  EAELRDELLDSPPASPSGSYITADGDSWASSPSCSLSLLAPAEGLDFPSGWGLSPQGSMV 260
                   L  + P+S S  + T    +  SS S   +   P  G    S    +P     
Sbjct: 3338 STGDTTPLPVTSPSSASTGHTTPLHVTIPSSASTGDTSTLPVTGASSASTGHATPLPVTD 3397

Query: 261  DERELHPAGTPEPPSSESSLSADSSS-------SWGQEGHFFDLDFLANDPMIPAALLPF 313
                     TP P +S SS+S   ++       S    G    L   +   +      P 
Sbjct: 3398 TSSVSTGHATPLPVTSLSSVSTGDTTPLPVTDASSASTGQATPLPVTSLSSVSTGDTTPL 3457

Query: 314  QGSLIFQVEAVEVTPLSPEEEEEEAVADPDPGGDLAGEGEEDSTSASFLQSLSDLSITEG 373
              +    V     TPL   +    +       GD       D++SAS  Q+ + L +T  
Sbjct: 3458 LVTDASSVSTGHATPLPVTDTSSAST------GDTTRLPVTDTSSASTGQA-TPLPVTSL 3510

Query: 374  MDEAFAFRDDTSAASSDSDSASYAEADDERLYSGEPHAQATLLQDSVQKTEEESGGGAKG 433
               + +  D T    +D+ S S   A    +      +     +  V  T   S G A  
Sbjct: 3511 --SSVSTGDTTPLLVTDASSVSTGHATPLPVTDTSSASTGDTTRLPVTDTSSASTGQATP 3568

Query: 434  LQAQDGTVSWAVEAAPQTSDRGAYLSQRQELISEVTEEGLALGQESTATVTPHTLQVAPG 493
            L     + S +    P      + +S        VT    A    ST  VTP  +     
Sbjct: 3569 LPVTIPSSSSSGHTTPLPVTSTSSVSTGHVTPLHVTSPSSA----STGHVTPLPVTSTSS 3624

Query: 494  LQVEVATRVTPQAGEEETDSTAGQESAAMAMPQPSQEGISEILGQESVTAEKLPTPQEET 553
                 AT +          + A   S   A P P  +  S      + T +  P P  +T
Sbjct: 3625 ASTGHATPLLV--------TDASSVSTGHATPLPVTDASS------ASTGDTTPLPVTDT 3670

Query: 554  SLTLCPDSPQNLKEEGGLDLPSGRKPVAAATIVPRQAKEDLTLPQDSAMTPPLPLQDTDL 613
            S                            AT +P  +   ++    +  T PLP+ D   
Sbjct: 3671 SSA----------------------STGQATPLPVTSLSSVS----TGDTTPLPVTDASS 3704

Query: 614  SSAPKPVAAATIVSQQAEEGLTLPQDSVMTPPLPLQDTELSSAPKPVAAATLVSQQAEEG 673
            +S          +      G T+P    +    P   +   + P PV   +  S      
Sbjct: 3705 ASTGHATPLPVTIPSSVSTGDTMP----LPVTSPSSASTGHATPLPVTGLSSAS------ 3754

Query: 674  LTLPQDSAMTPPLPLQDTDLSSA----PKPVAAATLVSQQAEEGLTLPQDSAMTP----P 725
                  +  T PLP+ DT  +S     P PV   +  S      L +   S+ +     P
Sbjct: 3755 ------TGDTTPLPVTDTSSASTRHATPLPVTDTSSASTDDTTRLPVTDVSSASTGHATP 3808

Query: 726  LPLQDTDLSSA----PKPVAAATLVSQQAEEGLTLPQDSAMTP----PLPLQDTDLSSA- 776
            LP+  T  +S     P PV   + VS      L +   S+ +     PLP+ DT   S  
Sbjct: 3809 LPVTSTSSASTGDTTPLPVTDTSSVSTGHATSLPVTSRSSASTGHATPLPVTDTSSVSTG 3868

Query: 777  ---PKPVAAATIVSQQAEEGLTLPQDSAMTP----PLPLQDTDLSSA----PKPVAAATI 825
               P PV + + VS      L +   S+ +     P+P+  T  +S     P PV  A+ 
Sbjct: 3869 HATPLPVTSTSSVSTGHATPLPVTSPSSASTGHATPVPVTSTSSASTGDTTPLPVTNASS 3928

Query: 826  VSQQAEEGL--TLPQDSAMTPPLPLQDTDLSSAPKPVAAATPVSQQAEEGLTLPQDSAMT 883
            +S      L  T P  ++      L  TD SSA    A   P++  +         +  T
Sbjct: 3929 LSTGHATPLHVTSPSSASRGDTSTLPVTDASSASTGHATPLPLTSLSSVS------TGDT 3982

Query: 884  PPLPLQDTDLSSA------PKPVAAATPVSQQAEEGL--TLPQ--DSAMTAPLPLQDTGP 933
             PLP+  TD SSA      P PV + + VS      L  T+P    S  T  LP+ D   
Sbjct: 3983 TPLPV--TDTSSASTGQATPLPVTSLSSVSTGDTTPLPVTIPSSASSGHTTSLPVTDASS 4040

Query: 934  TSGPEPLAVATPQTLQAEAGCAPGTEPVATMAQQEVGEALGPRPAPEEKNAAL-PTVPEP 992
             S      +    T  A  G      PV   +    G A  P P  +  +A+     P P
Sbjct: 4041 VSTGHGTPLPVTSTSSASTGDTTPL-PVTDTSSASTGHAT-PLPVTDTSSASTGHATPLP 4098

Query: 993  -AALDQVQQDDPQPAAEAGTPWAAQEDADSTLGMEALSLPEPA 1034
              +L  V      P A +    A+   +DS L ME   +  P+
Sbjct: 4099 VTSLSSVSTGHATPLAVSSATSASTVSSDSPLKMETPGMTTPS 4141



 Score = 72.4 bits (176), Expect = 3e-12
 Identities = 282/1295 (21%), Positives = 402/1295 (31%), Gaps = 176/1295 (13%)

Query: 18   PGPRTDLSCDAAAATTILGGDRREPCALTPG---PSHLALTFLPSKPGARPQPEGASWDA 74
            P P TD S  +   TT L        +L+ G   P H+      S   A P P  ++  A
Sbjct: 1616 PLPVTDTSSASTGDTTPLPVTNAS--SLSTGHATPLHVTSPSSASTGHATPLPVTSTSSA 1673

Query: 75   GPGGA---PSAWADPGEGGPSPMLLPEGLSSQALSTEAPLPATLEPRIVMGEETCQALLS 131
              G A   P           +  L    +SS +     PLP T    +  G+ T   + S
Sbjct: 1674 STGHATPLPVTGLSSATTDDTTRLPVTDVSSASTGQATPLPVTSLSSVSTGDTTPLPVTS 1733

Query: 132  PRAARTALRDQEGGHASPDPPPELCSQG-DLSVPSPPPDPDSFFTPPSTPTKTTYALLPA 190
            P +A T       GHASP    +  S     + P P  D  S  T  +TP       LP 
Sbjct: 1734 PSSAST-------GHASPLLVTDASSASTGQATPLPVTDTSSVSTAHATP-------LPV 1779

Query: 191  CGPHGDARDSEAEL---------RDELLDSPPASPSGSYITADGDSWASSPSCSLSLLAP 241
             G    + D    L           + +  P  SPS +   + GD+    P    S  + 
Sbjct: 1780 TGLSSASTDDTTRLPVTDVSSASTGQAIPLPVTSPSSA---STGDT-TPLPVTDASSAST 1835

Query: 242  AEGLDFPSGWGLSPQGSMVDERELHPAGTPEPPSSESSLSADSSSSWGQEGHFFDLDFLA 301
             +    P     S          +  A +     + S L  D+SS     G    L    
Sbjct: 1836 GDTTSLPVTIPSSASSGHTTSLPVTDASSVSTGHATSLLVTDASSV--STGDTTPLPVTD 1893

Query: 302  NDPMIPAALLPFQGSLIFQVEAVEVTPLSPEEEEEEAVADPDP----GGDLAGEGEEDS- 356
             +        P   +    V     T L        +  D  P        A  G     
Sbjct: 1894 TNSASTGDTTPLHVTDASSVSTGHATSLPVTSLSSASTGDTTPLPVTSPSSASSGHTTPL 1953

Query: 357  --TSASFLQS--LSDLSITEGMDEAFAFRDDTSAASSDSDSASYAEADDERLYSGEPHAQ 412
              T AS + +   + L +T+    +           + S S  +A        S     Q
Sbjct: 1954 PVTDASSVPTGHATSLPVTDASSVSTGHATPLPVTDASSVSTGHATPLPVTDTSSVSTGQ 2013

Query: 413  ATLLQDSVQKTEEESGGGAKGLQAQDGTVSWAVEAAPQTSDRGAYLSQRQELISEVTEEG 472
            AT L   V      S G    L   D + +   +  P      + +S        VT   
Sbjct: 2014 ATPL--PVTSLSSASTGDTTPLPVTDTSSASTGQDTPLPVTSLSSVSTGDTTPLPVTSPS 2071

Query: 473  LALGQESTATVTPHTLQVAPGLQVEVATR--VTPQAGEEETDSTAGQESAAMAMPQPSQE 530
             A    ST   TP  +  A  +    AT   VT  +      +TA   + A ++      
Sbjct: 2072 SA----STGHATPLLVTDASSVSTGHATSLLVTDASSVSTGHATALHVTDASSLSTGDTT 2127

Query: 531  GISEILGQESVTAEKLPTPQEETSLTLCPDSPQNLKEEGGLDLPSGRKPVAAATIVPRQA 590
             +       + T +  P P  +TS         ++       LP      A+        
Sbjct: 2128 PLPVTSPSSASTGDTTPLPVTDTS---------SVSTGHATSLPVTDTSSASTGHATSLP 2178

Query: 591  KEDLTLPQDSAMTPPLPLQDTDLSSAPKPVAAATIVSQQAEEGLTLP------QDSVMTP 644
              D +       TP LP+ DT  +S  +           A  G  +P        +    
Sbjct: 2179 VTDTSSASTGHATP-LPVTDTSSASTGQATPLPVTSPSSASTGHAIPLLVTDTSSASTGQ 2237

Query: 645  PLPLQDTELSSA------PKPVAAATLVSQQAEEGL------------------TLPQDS 680
              PL  T LSSA      P PV  A+ VS      L                  T P  +
Sbjct: 2238 ATPLPVTSLSSASTGDTTPLPVTDASSVSTGHATSLPVTSLSSVSTGDTTPLPVTSPSSA 2297

Query: 681  AMTPPLPLQDTDLSSA------PKPVAAATLVSQQAEEGL--TLPQDSAMTPPLPLQDTD 732
            +     PL  TD SSA      P PV + +  S      L  T P  ++     PL  TD
Sbjct: 2298 STGHATPLHVTDASSASTGHATPLPVTSLSSASTGDTTPLPVTSPSSASTGHATPLHVTD 2357

Query: 733  LSS------APKPVAAATLVSQQAEEGLTLPQDSAM----TPPLPLQDTD---------- 772
             SS       P PV +++  S      L +   S+     T PLP+ DT           
Sbjct: 2358 ASSVSTGDTTPLPVTSSSSASSGHTTPLPVTDASSASTGDTTPLPVTDTSSASTGHATHL 2417

Query: 773  ----LSSA----PKPVAAATIVSQQAEEGLTLPQDSAM------TPPLPLQDTDLSS--- 815
                LSSA       +    + S        LP  S        T PLP  DT   S   
Sbjct: 2418 PVTGLSSASTGDTTRLPVTNVSSASTGHATPLPVTSTSSASTGDTTPLPGTDTSSVSTGH 2477

Query: 816  -APKPVAAATIVSQQAEEGLTLPQDSAM----TPPLPLQDTDLSS----APKPVAAATPV 866
              P  V  A+ VS      L +   S+     T PLP+ DT  +S     P PV  A+ +
Sbjct: 2478 TTPLLVTDASSVSTGDTTRLPVTSPSSASTGHTTPLPVTDTPSASTGDTTPLPVTNASSL 2537

Query: 867  SQQAEEGL--TLPQDSAMTPPLPLQDTDLSSAPKPVAAATPVSQQAEEGLTLPQDSAMTA 924
            S +    L  T P  ++      L  TD S+A    A   PV+       T    +  T 
Sbjct: 2538 STRHATSLHVTSPSSASTGHATSLPVTDTSAASTGHATPLPVTS------TSSASTGDTT 2591

Query: 925  PLPLQDTGPTSGPEPLAVATPQTLQAEAGCAPGTEPVATMAQQEVGEALGPRPAPEEKNA 984
            PLP+ DT   S  +   +    T  A  G      PV   +    G A    P P    +
Sbjct: 2592 PLPVTDTYSASTGQATPLPVTDTSSASTGDTTPL-PVTDTSSASTGHA---TPLPVTNTS 2647

Query: 985  ALPTVPEPAALDQVQQDDPQPAAEAGTPWAAQEDADSTLGMEALSLPEPASGAGEEIAEA 1044
            ++ T         +    P  A+   T      DA S     A SLP     +      A
Sbjct: 2648 SVST----GHATPLHVTSPSSASTGHTTPLPVTDASSVSTGHATSLP-VTDASSVFTGHA 2702

Query: 1045 LSRPGREACLEARAHTGDGAKPDSPQKETLEVENQQEGGLKPLAQEHGPRSALGGAREVP 1104
             S P       +  HT      D+    T    +        ++  H     +  A  V 
Sbjct: 2703 TSLPVTIPSSASSGHTTPLPVTDASSVSTGHATSLPVTDASSVSTGHATPLPVTDASSVS 2762

Query: 1105 DAPPAACPEVSQARLLSPAREERGLSGKSTPEPTLPSAVATEASLDSCPESSVGAVSSLD 1164
                   P  S + +          +G +TP P   ++ A+       P +S+ +VS+ D
Sbjct: 2763 TGHATPLPLTSLSSV---------STGDTTPLPVTDTSSASTGQATPLPVTSLSSVSTGD 2813

Query: 1165 RGCPDAPAPTSAPTSQQPE-PVLGLGSVEQPHEVP 1198
                     +SA T      PV    S    H  P
Sbjct: 2814 TTPLPVTDTSSASTGHATSLPVTDTSSASTGHATP 2848



 Score = 70.1 bits (170), Expect = 2e-11
 Identities = 189/799 (23%), Positives = 269/799 (33%), Gaps = 123/799 (15%)

Query: 605  PLPLQDTDLSSAPK--PVAAATIVSQQAEEGLTLPQDSVMTPP----LPLQDTELSSA-- 656
            PLP+ DT   S     P+    + S   ++   LP   V +      +PL  T  SSA  
Sbjct: 1760 PLPVTDTSSVSTAHATPLPVTGLSSASTDDTTRLPVTDVSSASTGQAIPLPVTSPSSAST 1819

Query: 657  ----PKPVAAATLVSQQAEEGL--TLPQDSAMTPPLPLQDTDLSSAPKPVAAATLVSQQA 710
                P PV  A+  S      L  T+P  ++      L  TD SS     A + LV+  +
Sbjct: 1820 GDTTPLPVTDASSASTGDTTSLPVTIPSSASSGHTTSLPVTDASSVSTGHATSLLVTDAS 1879

Query: 711  EEGLTLPQDSAMTPPLPLQDTDLSSA----PKPVAAATLVSQQAEEGLTLPQDSAM---- 762
                     +  T PLP+ DT+ +S     P  V  A+ VS      L +   S+     
Sbjct: 1880 SVS------TGDTTPLPVTDTNSASTGDTTPLHVTDASSVSTGHATSLPVTSLSSASTGD 1933

Query: 763  TPPLPLQDTDLSSA----PKPVAAATIVSQQAEEGLTLPQDSAMTP----PLPLQDTDLS 814
            T PLP+     +S+    P PV  A+ V       L +   S+++     PLP+ D    
Sbjct: 1934 TTPLPVTSPSSASSGHTTPLPVTDASSVPTGHATSLPVTDASSVSTGHATPLPVTDASSV 1993

Query: 815  SA----PKPVAAATIVSQQAEEGLTLPQDSAM----TPPLPLQDTDLSSA----PKPVAA 862
            S     P PV   + VS      L +   S+     T PLP+ DT  +S     P PV +
Sbjct: 1994 STGHATPLPVTDTSSVSTGQATPLPVTSLSSASTGDTTPLPVTDTSSASTGQDTPLPVTS 2053

Query: 863  ATPVSQQAEEGL--TLPQDSAMTPPLPLQDTDLSSAPKP------VAAATPVSQQAEEGL 914
             + VS      L  T P  ++     PL  TD SS          V  A+ VS      L
Sbjct: 2054 LSSVSTGDTTPLPVTSPSSASTGHATPLLVTDASSVSTGHATSLLVTDASSVSTGHATAL 2113

Query: 915  TLPQDSAM--------------------TAPLPLQDTGPTSGPEPLAVATPQTLQAEAGC 954
             +   S++                    T PLP+ DT   S     ++    T  A  G 
Sbjct: 2114 HVTDASSLSTGDTTPLPVTSPSSASTGDTTPLPVTDTSSVSTGHATSLPVTDTSSASTGH 2173

Query: 955  A---PGTE------------PVATMAQQEVGEALGPRPAPEEKNA----ALPTVPEPAAL 995
            A   P T+            PV   +    G+A  P P     +A    A+P +    + 
Sbjct: 2174 ATSLPVTDTSSASTGHATPLPVTDTSSASTGQAT-PLPVTSPSSASTGHAIPLLVTDTSS 2232

Query: 996  DQVQQDDPQP------AAEAGTPWAAQEDADSTLGMEALSLPEPASGA---GEEIAEALS 1046
                Q  P P      A+   T      DA S     A SLP  +  +   G+     ++
Sbjct: 2233 ASTGQATPLPVTSLSSASTGDTTPLPVTDASSVSTGHATSLPVTSLSSVSTGDTTPLPVT 2292

Query: 1047 RPGREACLEAR-AHTGDGAKPDSPQKETLEV---ENQQEGGLKPLAQEHGPRSALGGARE 1102
             P   +   A   H  D +   +     L V    +   G   PL     P SA  G   
Sbjct: 2293 SPSSASTGHATPLHVTDASSASTGHATPLPVTSLSSASTGDTTPLPVT-SPSSASTGHAT 2351

Query: 1103 VPDAPPAACPEVSQARLLSPAREERGLSGKSTPEPTLPSAVATEASLDSCPESSVGAVSS 1162
                  A+         L         SG +TP P   ++ A+       P +   + S+
Sbjct: 2352 PLHVTDASSVSTGDTTPLPVTSSSSASSGHTTPLPVTDASSASTGDTTPLPVTDTSSAST 2411

Query: 1163 LDRGCPDAPAPTSAPTSQQPE-PVLGLGSVEQPHEVPSVLGTPLLQPPENLAKGQPSTPV 1221
                       +SA T      PV  + S    H       TPL     + A    +TP+
Sbjct: 2412 GHATHLPVTGLSSASTGDTTRLPVTNVSSASTGH------ATPLPVTSTSSASTGDTTPL 2465

Query: 1222 DRPLGPDPSAPGTLAGAALPPLEPPAPCLCQDPQEDSVEDEEPPGSLGLPPPQAGVQPAA 1281
                G D S+  T  G   P L   A  +                S G   P   V    
Sbjct: 2466 P---GTDTSSVST--GHTTPLLVTDASSVSTGDTTRLPVTSPSSASTGHTTP-LPVTDTP 2519

Query: 1282 AAVSGTTQPLGTGPRVSLS 1300
            +A +G T PL      SLS
Sbjct: 2520 SASTGDTTPLPVTNASSLS 2538



 Score = 40.4 bits (93), Expect = 0.014
 Identities = 198/951 (20%), Positives = 304/951 (31%), Gaps = 161/951 (16%)

Query: 350  GEGEEDSTSA--SFLQSLSDLSITEGMDEAFAFRDDTSAASSDSDSASYAEADDERLYSG 407
            G  EE ST+   S     S +SIT G +        TS  +S  D+++ ++    R    
Sbjct: 149  GNTEETSTAGTESSTPVTSAVSITAGQEGQSR---TTSWRTSIQDTSASSQNHWTRSTQT 205

Query: 408  EPHAQATLLQDSVQKTEEESGGGAKGLQAQDGTVSWAVEAAPQTSDRGAYL-----SQRQ 462
               +Q + L      T   S      +    GTVS     + +T+               
Sbjct: 206  TRESQTSTLTHRTTSTPSFS----PSVHNVTGTVSQKTSPSGETATSSLCSVTNTSMMTS 261

Query: 463  ELISEVTEEGLALGQESTATVTPHTLQVAPGLQVEVATRVTPQAGEEETDS-TAGQESAA 521
            E I+  T  G  LG     +  P T  + P     + T   P+     T S T+ Q++ A
Sbjct: 262  EKITVTTSTGSTLGNPGETSSVPVTGSLMPVTSAALVT-FDPEGQSPATFSRTSTQDTTA 320

Query: 522  MAMPQPSQEGISEILGQESVTAEKLPTPQEETSLTLCPDSPQNLKEEGGLD---LPSGRK 578
             +    +Q   +  + Q +      P     TS  L   SP      G +     PSG  
Sbjct: 321  FSKNHQTQSVETTRVSQINTLNTLTPVT---TSTVL--SSPSGFNPSGTVSQETFPSGET 375

Query: 579  PVAAATIVPRQAKEDLTLPQDSAMTPPLPLQDTDLSSAPKPVAAATIVSQQAEEGLTLPQ 638
              ++ + V      +  L        P     T  ++    ++ +  +S    +  T+  
Sbjct: 376  TTSSPSSV-----SNTFLVTSKVFRMPTSRDSTLGNTEETSLSVSGTISAITSKVSTIWW 430

Query: 639  DSVMTPPLPLQDTELSSAPKPVAAATLVSQQAEEGLTLPQDSAMTPPLPLQDTDLSSAPK 698
               ++       T LS +  P   +T    Q  EG       A T   P + +  S    
Sbjct: 431  SDTLS-------TALSPSSLPPKISTAFHTQQSEG-------AETTGRPHERSSFSPG-- 474

Query: 699  PVAAATLVSQQA---EEGLTLPQDSAMTPPLPLQDTDLSSAPKPVAAATLVSQQAEEGL- 754
                   VSQ+     E  T P   +         T+L S     AA  LV+     G  
Sbjct: 475  -------VSQEIFTLHETTTWPSSFSSKGHTTWSQTELPSTSTG-AATRLVTGNPSTGTA 526

Query: 755  -TLPQDSAMTPPL--PLQDTDLSS----APKPVAAATIVSQQAEEGLTLPQDSAMTPPLP 807
             T+P+  +    +  P + T  SS     PK   A        E G T   ++ ++ P  
Sbjct: 527  GTIPRVPSKVSAIGEPGEPTTYSSHSTTLPKTTGAGAQTQWTQETGTT--GEALLSSPSY 584

Query: 808  LQDTDLSSAPKPVAAATIVSQQAEEGLTLPQDSAMTPPLPLQDTDLSSAPKPVAAA---T 864
                 + +A  P ++  +    +++  T P  +  T    +  T  S    P  +    T
Sbjct: 585  SVTQMIKTATSPSSSPMLDRHTSQQITTAPSTNHST----IHSTSTSPQESPAVSQRGHT 640

Query: 865  PVSQQAEEGLTLPQDSAMTPPLPLQDTDLSSAPKPVAAATPVSQQAEEGLTLPQD----S 920
               Q  +E  T    S MT        D  +   P ++ T       E   +PQD    S
Sbjct: 641  QAPQTTQESQTTRSVSPMT--------DTKTVTTPGSSFTASGHSPSE--IVPQDAPTIS 690

Query: 921  AMT--APLPLQDTGPTSGPEPLAVATPQTLQAEAGCAPGTEPVATMAQQEVGEALGPRPA 978
            A T  AP P  D   T  P     A P +  A  G + GT    T A       +     
Sbjct: 691  AATTFAPAPTGDGHTTQAPTTALQAAPSSHDATLGPSGGTSLSKTGALTLANSVVSTPGG 750

Query: 979  PEEK--NAALPTVPEPAAL-------------DQVQQDDPQPA----AEAGTPWAAQEDA 1019
            PE +  +A+  T P+ AA               Q Q  +P  +      AGT   +   A
Sbjct: 751  PEGQWTSASASTSPDTAAAMTHTHQAESTEASGQTQTSEPASSGSRTTSAGTATPSSSGA 810

Query: 1020 DSTL--GMEALSL----------PEPASGAGEEIAEALSRPGREACLEAR---------- 1057
              T   G E +S           P   S   +   E LS       +             
Sbjct: 811  SGTTPSGSEGISTSGETTRFSSNPSRDSHTTQSTTELLSASASHGAIPVSTGMASSIVPG 870

Query: 1058 ------AHTGDGAKPDSPQKETLEVENQQE-GGLKPLAQEHGPRSALGG--------ARE 1102
                  +      +P      T    + QE   +  +AQ    R++ G         A +
Sbjct: 871  TFHPTLSEASTAGRPTGQSSPTSPSASPQETAAISRMAQTQRTRTSRGSDTISLASQATD 930

Query: 1103 VPDAPPAACPEVSQARLLSPAREERGL----SGKS------TPEPTLPSAVATEASLDSC 1152
                 P   P ++   L SP  E   L    SGK+      +    LP   A+ AS    
Sbjct: 931  TFSTVPPTPPSITSTGLTSPQTETHTLSPSGSGKTFTTALISNATPLPVTYASSASTGHT 990

Query: 1153 PESSVGAVSSLDRGCPDAPAPTSAPTS-----QQPEPVLGLGSVEQPHEVP 1198
                V   SS+  G    P P ++P+S       P PV    S    H  P
Sbjct: 991  TPLHVTDASSVSTG-HATPLPVTSPSSVSTGHTTPLPVTDTSSESTGHVTP 1040


>gi|169205253 PREDICTED: hypothetical protein [Homo sapiens]
          Length = 3859

 Score = 87.0 bits (214), Expect = 1e-16
 Identities = 202/866 (23%), Positives = 295/866 (34%), Gaps = 131/866 (15%)

Query: 572  DLPSGRKPVAAATIVPRQAKEDLTLPQDSAMTPPLPLQDTDLSSAPKPVAAATIVSQQAE 631
            D P     +A +  VP    +   +P   A  P +P+   D    P   A   IVS    
Sbjct: 604  DSPVLSVTLADSPAVPVTPADSPVVPVTPADGPVVPVASADSPFVPVTPADDPIVSVTPA 663

Query: 632  EGLTLPQDSVMTPPLPLQDTELSSAPKPVAAATLVSQQAEEGLTLPQDSAMTPPLPLQDT 691
            E   +P     +P +P+   +    P   A   +V   A     +P   A TP  P+   
Sbjct: 664  ESPAIPVTQADSPVVPVTSADRPVIPVTTADGRIVPVTAAGDPIVPVTPADTPGSPVTSA 723

Query: 692  D-----LSSAPKPVAAAT-----LVSQQAEEGLTLPQDSAMTPPLPLQDTD-----LSSA 736
            D     ++SA  P    T     +V   + +G   P  SA  P +P+   D     +SSA
Sbjct: 724  DGPVVPVTSADSPFVPVTPPDGPVVPVTSADGPVAPVSSADGPVVPVTSADGPVAPVSSA 783

Query: 737  PKPVAAATLVSQQAEEGLTLPQDSAMTPPLPLQDTDLSSAPKPVAAATIVSQQAEEGLTL 796
              PV   T        G  +P  SA +P +P+   D    P   A   IV     +   +
Sbjct: 784  DGPVVPVTPAD---TNGPAVPVTSADSPFVPVIPADSPVVPVTPADDPIVPVTPADSSFV 840

Query: 797  PQDSAMTPPLPL----------QDTDLSSAPKPVAAATIVSQQAEEGLT--LPQDS---A 841
            P  SA +P +P+            TD+   P       +V   A+E +    P DS    
Sbjct: 841  PVISADSPFVPVIPADGPVVVDSSTDVLVVPVFPVNCILVPAFADETVVPLNPADSPVIP 900

Query: 842  MTPP----LPLQDTD-----LSSAPKPVAAATPVSQQAEEGLTLPQDSAMTPPLPLQDTD 892
            +TPP    +P+  TD     ++SA  PV   TP    A+     P  +A  P +P    D
Sbjct: 901  VTPPDDLVVPVTPTDCPVAPVTSADCPVVPVTPADSPAD-----PVTAADGPVVPFTPAD 955

Query: 893  LSSAPKPVAAATPVSQQAEEGLTLPQDSAMTAPLPLQDTGPTSGPEPLAVATPQTLQAEA 952
                P   A +  VS    +G  +P  SA +  +P+     T   +P+   TP    AE+
Sbjct: 956  DPIVPVTPADSPVVSVTPADGPVVPVASADSPFVPV-----TPADDPIVSVTP----AES 1006

Query: 953  GCAPGTE---PVATMAQQEVGEALGPRPAPEEKNAALPTVPEPAALDQVQQDDP-----Q 1004
               P T+   PV  +   +       RP      A    VP  AA D +    P      
Sbjct: 1007 PAIPVTQADSPVVPVTSAD-------RPVSPVTTADGRIVPVTAAGDPIVPVTPADTPGS 1059

Query: 1005 PAAEAGTPWAAQEDADSTLGMEALSLPE----PASGAGEEIAEALSRPGREACLE----- 1055
            P   A  P      ADS      ++ P+    P + A   +A   S  G    +      
Sbjct: 1060 PVTSADGPVVPVTSADSP--FVPVTPPDGPVVPVTSADGPVAPVSSADGPVVPVTSADGP 1117

Query: 1056 -ARAHTGDG-AKPDSPQKETLEVENQQEGGLKPLAQEHGP--RSALGGAREVP------- 1104
             A   + DG   P +P           +  + P+     P     L  +  VP       
Sbjct: 1118 VAPVSSADGPVVPVTPADSPFIPVTTADDPIVPVTPADSPVLSVTLADSPVVPVTPADSP 1177

Query: 1105 --DAPPAACPEV-----------------------SQARLLSPAREERG-LSGKSTPEPT 1138
                PPA  P V                       S   L+ P     G L      +P 
Sbjct: 1178 VIPVPPANGPVVPVSSADSPFVPVIPADGLVVLDSSTDVLVVPVSPTDGILVPDLADDPV 1237

Query: 1139 LPSAVATEASLDSCP-ESSVGAVSSLDRG-CPDAPAPTSAPTSQQPEPVLGLGSVEQPHE 1196
            +   +A    +   P +S V  V+S D    P  PA +         PV+ + + + P  
Sbjct: 1238 VSVTIADSPVIPVTPADSPVVPVTSADSPVVPVTPADSPVILVTPVGPVVSVTTADGPVV 1297

Query: 1197 VPSVLGTPLLQPPENLAKGQPSTPVDRPLGPDPSAPGTLAGAALPPLEPPAPCLCQDPQE 1256
            + S   +P++      +   P TP D P+ P  SA         P  +P  P    D   
Sbjct: 1298 LVSTADSPVIPVTSADSPVVPVTPADGPVVPVTSADSPFV-PVTPADDPIVPVTPADSPI 1356

Query: 1257 DSVEDEEPPGSLGLPPPQAGVQPAAAAVSGTTQPLGTGPRVSLSPHSPLLSPKVASMDAK 1316
             SV   E P ++ + P  + V P  +A S        G RV   P +P   P V    A 
Sbjct: 1357 VSVTPAESP-AIPVTPADSPVVPVTSADSPLIPLTTAGSRV--VPVTPTGDPIVPVTPAD 1413

Query: 1317 DLALQILPPCQVPPPSGPQSPAGPQG 1342
                   P   V    GP  P  P G
Sbjct: 1414 ------TPGSPVTSADGPVVPVTPAG 1433



 Score = 85.9 bits (211), Expect = 3e-16
 Identities = 190/878 (21%), Positives = 296/878 (33%), Gaps = 133/878 (15%)

Query: 572  DLPSGRKPVAAATIVPRQAKEDLTLPQDSAMTPPLPLQDTDLSSAPKPVAAATIVSQQAE 631
            D P     +A + +VP    +   +P   A  P +P+   D    P   A   +VS  + 
Sbjct: 334  DSPVLSVTLADSPVVPVTPADSPFVPAIPADGPVVPVTPADSPVVPVTPADGPVVSVASA 393

Query: 632  EGLTLPQDSVMTPPLPLQDTELSSAPKPVAAATLVSQQAEEGLTLPQDSAMTPPLPLQDT 691
            +   +P      P + +   +    P   A + L+     +G  +P  +A  P +P+   
Sbjct: 394  DSPFVPVTPADDPIVSVTPADSPVVPVTSADSPLIPVTTADGRVVPVTAAGDPIVPVTPA 453

Query: 692  D-----LSSAPKPVAAAT-----LVSQQAEEGLTLPQDSAMTPPLPLQDTDLSSAPKPVA 741
            D     ++SA  PV   T     LV     +G  +P  SA  P  P+   D    P   A
Sbjct: 454  DTPGSPVTSADGPVVPVTSADIPLVPVTPPDGPVVPVTSADGPVAPVSSADGPVVPVTPA 513

Query: 742  AATLVSQQAEEGLTLPQDSAMTPPLPLQDTDLSSAPKPVAAATIVSQQAEEGLTLPQDSA 801
             +  +     + L +P   A +P L +   +  + P   A + IV      G  +P  SA
Sbjct: 514  DSPFIPVTTADDLIVPVTPADSPVLSVTPAESPAIPVTPADSPIVPVTPANGPVVPVTSA 573

Query: 802  MTPPLPLQDTDLSSAPKPVAAATIVSQQAEEGLTLPQDSAMTPPLPLQDTDLSSAPKPVA 861
             +P +P+   D    P   A + +V     +   L    A +P +P+   D      PV 
Sbjct: 574  DSPFVPVIPADGPVVPVTPADSPVVPVTPADSPVLSVTLADSPAVPVTPAD-----SPVV 628

Query: 862  AATPVSQQAEEGLTLPQDSAMTPPLPLQDTD-------------------------LSSA 896
              TP      +G  +P  SA +P +P+   D                         ++SA
Sbjct: 629  PVTPA-----DGPVVPVASADSPFVPVTPADDPIVSVTPAESPAIPVTQADSPVVPVTSA 683

Query: 897  PKPVAAAT-------PVSQQAEEGLTLPQDSAMTAPLPLQDTGP----TSGPEPLAVATP 945
             +PV   T       PV+   +  + +       +P+   D GP    TS   P    TP
Sbjct: 684  DRPVIPVTTADGRIVPVTAAGDPIVPVTPADTPGSPVTSAD-GPVVPVTSADSPFVPVTP 742

Query: 946  ------QTLQAEAGCAPGTE---PVATMAQQE-----VGEALGPRPAPEEKNAALPTVPE 991
                      A+   AP +    PV  +   +     V  A GP       +   P VP 
Sbjct: 743  PDGPVVPVTSADGPVAPVSSADGPVVPVTSADGPVAPVSSADGPVVPVTPADTNGPAVPV 802

Query: 992  PAA----LDQVQQDDP-QPAAEAGTPWAAQEDADST----LGMEALSLPE-PASG--AGE 1039
             +A    +  +  D P  P   A  P      ADS+    +  ++  +P  PA G    +
Sbjct: 803  TSADSPFVPVIPADSPVVPVTPADDPIVPVTPADSSFVPVISADSPFVPVIPADGPVVVD 862

Query: 1040 EIAEALSRPGREA-CLEARAHTGDGAKPDSPQKETLEVENQQEGGLKPLAQEHGPRSALG 1098
               + L  P     C+   A   +   P +P    +      +  + P+     P     
Sbjct: 863  SSTDVLVVPVFPVNCILVPAFADETVVPLNPADSPVIPVTPPDDLVVPVTPTDCP----- 917

Query: 1099 GAREVPDAPPAACPEVSQARLLSPAREERGLSGKSTP-----EPTLPSAVATEASLDSCP 1153
                V     A CP V      SPA       G   P     +P +P   A    +   P
Sbjct: 918  ----VAPVTSADCPVVPVTPADSPADPVTAADGPVVPFTPADDPIVPVTPADSPVVSVTP 973

Query: 1154 -ESSVGAVSSLDRG-CPDAPA-----------PTSAPTSQQPEPVLGLGSVEQP------ 1194
             +  V  V+S D    P  PA             + P +Q   PV+ + S ++P      
Sbjct: 974  ADGPVVPVASADSPFVPVTPADDPIVSVTPAESPAIPVTQADSPVVPVTSADRPVSPVTT 1033

Query: 1195 ---HEVP-SVLGTPLLQPPENLAKGQPSTPVDRPLGPDPSAPGTLAGAALPPLEPPAPCL 1250
                 VP +  G P++        G P T  D P+ P  SA         PP  P  P  
Sbjct: 1034 ADGRIVPVTAAGDPIVPVTPADTPGSPVTSADGPVVPVTSADSPFV-PVTPPDGPVVPVT 1092

Query: 1251 CQDPQEDSVEDEEPP-----GSLGLPPPQAGVQPAAAAVSGTTQPL-----GTGPRVSLS 1300
              D     V   + P      + G   P +        V+    P         P V ++
Sbjct: 1093 SADGPVAPVSSADGPVVPVTSADGPVAPVSSADGPVVPVTPADSPFIPVTTADDPIVPVT 1152

Query: 1301 P-HSPLLSPKVASMDAKDLALQILPPCQVPPPSGPQSP 1337
            P  SP+LS  +A      +     P   VPP +GP  P
Sbjct: 1153 PADSPVLSVTLADSPVVPVTPADSPVIPVPPANGPVVP 1190



 Score = 85.9 bits (211), Expect = 3e-16
 Identities = 161/790 (20%), Positives = 256/790 (32%), Gaps = 85/790 (10%)

Query: 572  DLPSGRKPVAAATIVPRQAKEDLTLPQDSAMTPPLPLQDTDLSSAPKPVAAATIVSQQAE 631
            D P      A   +VP    +    P  +A  P +P    D    P   A + +VS    
Sbjct: 915  DCPVAPVTSADCPVVPVTPADSPADPVTAADGPVVPFTPADDPIVPVTPADSPVVSVTPA 974

Query: 632  EGLTLPQDSVMTPPLPLQDTELSSAPKPVAAATLVSQQAEEGLTLPQDSAMTPPLPLQDT 691
            +G  +P  S  +P +P+     + A  P+ + T     A     +P   A +P +P+   
Sbjct: 975  DGPVVPVASADSPFVPV-----TPADDPIVSVTPAESPA-----IPVTQADSPVVPVTSA 1024

Query: 692  DLSSAPKPVAAATLVSQQAEEGLTLPQDSAMTPPLPLQDTD-----LSSAPKPVAAAT-- 744
            D   +P   A   +V   A     +P   A TP  P+   D     ++SA  P    T  
Sbjct: 1025 DRPVSPVTTADGRIVPVTAAGDPIVPVTPADTPGSPVTSADGPVVPVTSADSPFVPVTPP 1084

Query: 745  ---LVSQQAEEGLTLPQDSAMTPPLPLQDTDLSSAPKPVAAATIVSQQAEEGLTLPQDSA 801
               +V   + +G   P  SA  P +P+   D   AP   A   +V     +   +P  +A
Sbjct: 1085 DGPVVPVTSADGPVAPVSSADGPVVPVTSADGPVAPVSSADGPVVPVTPADSPFIPVTTA 1144

Query: 802  MTPPLPLQDTDLSSAPKPVAAATIVSQQAEEGLTLPQDSAMTPPLPLQDTDLSSAPKPVA 861
              P +P+   D       +A + +V     +   +P   A  P +P+   D    P   A
Sbjct: 1145 DDPIVPVTPADSPVLSVTLADSPVVPVTPADSPVIPVPPANGPVVPVSSADSPFVPVIPA 1204

Query: 862  AATPVSQQAEEGLTL---PQDSAMTPPLPLQD-TDLSSAPKPVAAATPVSQQAEEGLTLP 917
                V   + + L +   P D  + P L       ++ A  PV   TP      +   +P
Sbjct: 1205 DGLVVLDSSTDVLVVPVSPTDGILVPDLADDPVVSVTIADSPVIPVTPA-----DSPVVP 1259

Query: 918  QDSAMTAPLPLQDTGPTSGPEPLAVATPQTLQAEAGCAPGTEPVATMAQQEVGEALGPRP 977
              SA +  +P+     T    P+ + TP         A G   + + A   V       P
Sbjct: 1260 VTSADSPVVPV-----TPADSPVILVTPVGPVVSVTTADGPVVLVSTADSPV------IP 1308

Query: 978  APEEKNAALPTVPEPAALDQVQQDDPQ--PAAEAGTPWAAQEDADSTLGMEALSLPEPAS 1035
                 +  +P  P    +  V   D    P   A  P      ADS + +       PA 
Sbjct: 1309 VTSADSPVVPVTPADGPVVPVTSADSPFVPVTPADDPIVPVTPADSPI-VSVTPAESPAI 1367

Query: 1036 GAGEEIAEALSRPGREACLEARAHTGDGAKPDSPQKETLEVENQQEGGLKPLAQEHGPRS 1095
                  +  +     ++ L      G    P +P  + +      +    P+    GP  
Sbjct: 1368 PVTPADSPVVPVTSADSPLIPLTTAGSRVVPVTPTGDPIVPVTPADTPGSPVTSADGP-- 1425

Query: 1096 ALGGAREVPDAPPAACPEVSQARLLSPAREERGLSGKSTPEPTLPSAVATEASLDSCPES 1155
                   V    PA  P V      +P        G   P  T              P+ 
Sbjct: 1426 -------VVPVTPAGDPIVPVTPADTPGSPVTSADGPVVPVTT--------------PDG 1464

Query: 1156 SVGAVSSLDRGCPDAPAPTSAPTSQQPEPVLGLGSVEQPHEVPSVLGTPLLQPPENLAKG 1215
             +  VS      PD P     P +    PV+ +   + P    +    P++      +  
Sbjct: 1465 PLVPVSP-----PDGPV---VPVTSADGPVVPVTPADSPFIPVTTADDPIVPVTPADSPV 1516

Query: 1216 QPSTPVDRPLGPDPSAPG-----TLAGAALPPLEPPAPCLCQDPQEDSVEDEEPPGSLGL 1270
             P TP D P+ P   A G     T A     P+ P    +  D   D +     P   G+
Sbjct: 1517 VPVTPADIPVVPVTPANGPVIHVTSADCPFVPVIPADGLVALDSSTDVLVVPVSPTD-GV 1575

Query: 1271 PPPQAGVQPAAAAVSGTTQPLGTGPRVSLSPHSPLLSPKVASMDAKDLALQILPPCQVPP 1330
              P     P  +     +  +   P  S      L    V  + + D     +P   V P
Sbjct: 1576 LVPDLADDPVVSVTIADSPVIPVTPADSTVVPVTLADGPVVPVTSVD-----IPVVPVTP 1630

Query: 1331 PSGPQSPAGP 1340
             +GP +P  P
Sbjct: 1631 ANGPVAPVTP 1640



 Score = 85.1 bits (209), Expect = 5e-16
 Identities = 178/826 (21%), Positives = 270/826 (32%), Gaps = 118/826 (14%)

Query: 560  DSPQNLKEEGGLDLPSGRKPVAAATIVPRQAKEDLTLPQDSAMTPPLPLQDTD-----LS 614
            DSP         D P      A   +VP  + + L +P   A  P +P+   D     +S
Sbjct: 1712 DSPVVPVTSADTDSPGSPVTSADGPVVPVTSADSLPVPVTPADGPVVPVTSADGPVAPVS 1771

Query: 615  SAPKPVAAAT-----IVSQQAEEGLTLPQDSVMTPPLPLQDTELSSAPKPVAAATLVSQQ 669
            SA  PV   T     +V     +  T+P     +P +P+        P   A +  V   
Sbjct: 1772 SADGPVVPVTPADSPVVPVTTADDPTVPVTPADSPVVPVPPANGPIVPVTSADSPFVPVI 1831

Query: 670  AEEGLTLPQDSAMTPPLPLQDTDLSSAPKPVAAATLVSQQAEEGLTLPQDSAMTPPLPLQ 729
              +GL +   S     +P+  TD    P  +A   +VS    +   +P   A +P + + 
Sbjct: 1832 PADGLVVLDSSTDVLVVPVSPTDGILVP-DLADDPVVSVTIADSPVIPVTPADSPVVLVT 1890

Query: 730  DTDLSSAPKPVAAATLVSQQAEEGLTLPQDSAMTPPLPLQDTDLSSAPKPVAAATIVSQQ 789
              D    P       +V     +   +P      P +P+   D    P   A + IVS  
Sbjct: 1891 PADGPVVPVTSVDNPVVPVTPADNPVIPVTPVDDPVVPVTPADDPIVPVTSADSPIVSVT 1950

Query: 790  AEEGLTLPQDSAMTPPLPLQDTDLSSAPKPVAAATIVSQQAEEGLTLPQDSAMTPPLPLQ 849
              +    P   A +P +P+   D    P   A   +V     +G  +P   A +P +P+ 
Sbjct: 1951 PADSPVFPVTPADSPVIPVASADSPLVPVTPADMVVVPVIPADGPVIPVTPAESPAIPVT 2010

Query: 850  DTD-----LSSAPKPVAAATPVSQQAEEGLTLPQDSAMTPPLPLQDTDLSSAP--KPVAA 902
             TD     ++SA  PV    PV+  +      P DS + P  P  D  +   P   PV  
Sbjct: 2011 PTDSPVVPVTSADSPV---IPVTADSPFVPVTPADSPVIPVTPPDDLVVPVTPIDCPVVP 2067

Query: 903  ATPVSQQAEEGLTLPQDSAMTAPLPLQDTGPTSGPEPLAVATPQTLQAEAGCAPGTEPVA 962
             T V          P  S   A  P+    P  GP       P T        P   PV 
Sbjct: 2068 VTLVD--------CPVVSVTPANSPVDPVTPADGP-----VVPVT--------PADSPVI 2106

Query: 963  TMAQQEVGEALGPRPAPEEKNAALPTVPEPAALDQVQQDDPQ--PAAEAGTPWAAQEDAD 1020
                          P     +  +P  P  + +  V   D    P   A +P  +   AD
Sbjct: 2107 --------------PVTPADDLIVPVTPADSLIVSVTPADSPVVPVTPADSPVISVASAD 2152

Query: 1021 STL----GMEALSLP-EPASGAGEEIAEALSRPGREACLEARAHTGDGAKPDSPQKETLE 1075
            S +      + + +P  PA G    +  A S                 A P +P    + 
Sbjct: 2153 SPVVPVTPADTVVVPVTPADGPVIPVTPAES----------------PAIPVTPADSPVV 2196

Query: 1076 VENQQEGGLKPLAQEHGPRSALGGAREVPDAPPAACPEVSQARLLSPAREERGLSGKSTP 1135
                 +  + P+     P         +   PPA+ P V      +P        G   P
Sbjct: 2197 PVTPADDPVVPVTPADSP---------IVPVPPASDPVVPVTPADTPGSPVASADGPVVP 2247

Query: 1136 EPTLPSAVATEASLDSCPESSVGAVSSLDRGCPDAPAPTSAPTSQQPEPVLGLGSVEQPH 1195
              +  S +      DS P   V    S       A  P   P +   +PV  +   + P 
Sbjct: 2248 VTSADSPLVPVTPGDS-PVVPVTPADSPVFPVTSADGPV-FPVTLADDPVFPVTPADDPI 2305

Query: 1196 EVPSVLGTPLLQPPENLAKGQPSTPVDRPLGPDPSA-----PGTLAGAALPPLEPPAPCL 1250
               S   +P++          P TP + P+ P P A     P T AG+   P+ P    +
Sbjct: 2306 FPVSPADSPVV----------PVTPANIPVVPVPPANGSVVPVTSAGSPFVPIIPADGLV 2355

Query: 1251 CQDPQEDSVEDEEPPGSLGLPPPQAGVQPAAAAVSGTTQPLGTGPRVS-LSPHSPLLSP- 1308
              D   D +     P   G+P P     P  +  +  +  +   P  S + P +P   P 
Sbjct: 2356 VLDSSTDVLVVLVSPTD-GIPVPDLADDPVVSVTTSDSPVIPVTPTDSPVVPVAPADGPV 2414

Query: 1309 -KVASMDAKDLALQILPPCQVPPPSGPQSPAGP-QGLSAPEQQEDE 1352
              V S+D+        P   V P   P  P  P   L  P    D+
Sbjct: 2415 VPVTSVDS--------PVVPVTPADSPVIPVTPADSLVVPATPADD 2452



 Score = 83.6 bits (205), Expect = 1e-15
 Identities = 178/824 (21%), Positives = 276/824 (33%), Gaps = 113/824 (13%)

Query: 585  IVPRQAKEDLTLPQDSAMTPPLPLQDTDLSSAPKPVAAATIVSQQAEEGLTLPQDSVMTP 644
            +VP    + + +P D A  P + +   D    P   A +T+V     +G  +P  SV  P
Sbjct: 1566 VVPVSPTDGVLVP-DLADDPVVSVTIADSPVIPVTPADSTVVPVTLADGPVVPVTSVDIP 1624

Query: 645  PLPLQDTELSSAPKPVAAATLVSQQAEEGLTLPQDSAMTPPLPLQDTD-----LSSAPKP 699
             +P+       AP       +VS    +G  +P  SA  P +P+   D     ++ A  P
Sbjct: 1625 VVPVTPANGPVAPVTPVDDPVVSVNPADGSVVPVTSADCPVVPVTPADGLVVPVTPADSP 1684

Query: 700  VAAAT-----LVSQQAEEGLTLPQDSAMTPPLPLQDTDLSSAPKPVAAAT---------- 744
            +   T     +V   + +   +P   A +P +P+   D  S   PV +A           
Sbjct: 1685 IVPVTPADSPVVLVTSADSPVIPVTPADSPVVPVTSADTDSPGSPVTSADGPVVPVTSAD 1744

Query: 745  --LVSQQAEEGLTLPQDSAMTPPLPLQDTDLSSAPKPVAAATIVSQQAEEGLTLPQDSAM 802
               V     +G  +P  SA  P  P+   D    P   A + +V     +  T+P   A 
Sbjct: 1745 SLPVPVTPADGPVVPVTSADGPVAPVSSADGPVVPVTPADSPVVPVTTADDPTVPVTPAD 1804

Query: 803  TPPLPLQDTDLSSAPKPVAAATIVSQQAEEGLTLPQDSAMTPPLPLQDTD---------- 852
            +P +P+   +    P   A +  V     +GL +   S     +P+  TD          
Sbjct: 1805 SPVVPVPPANGPIVPVTSADSPFVPVIPADGLVVLDSSTDVLVVPVSPTDGILVPDLADD 1864

Query: 853  ----LSSAPKPVAAATPVSQQA-----EEGLTLPQDSAMTPPLPLQDTDLSSAPKPVAAA 903
                ++ A  PV   TP           +G  +P  S   P +P+   D      PV   
Sbjct: 1865 PVVSVTIADSPVIPVTPADSPVVLVTPADGPVVPVTSVDNPVVPVTPAD-----NPVIPV 1919

Query: 904  TPVSQQAEEGLTLPQDSAM----TAPLPLQDTGPTSGPE-PLAVATPQTLQAEAGCAPGT 958
            TPV          P D  +    +A  P+    P   P  P+  A    +   +  +P  
Sbjct: 1920 TPVDDPVVP--VTPADDPIVPVTSADSPIVSVTPADSPVFPVTPADSPVIPVASADSP-L 1976

Query: 959  EPV--ATMAQQEVGEALGP-RPAPEEKNAALPTVPEPAALDQV-QQDDPQPAAEAGTPWA 1014
             PV  A M    V  A GP  P    ++ A+P  P  + +  V   D P     A +P+ 
Sbjct: 1977 VPVTPADMVVVPVIPADGPVIPVTPAESPAIPVTPTDSPVVPVTSADSPVIPVTADSPFV 2036

Query: 1015 AQEDADSTL----GMEALSLPEPASGAGEEIAEALSRPGREACLEARAHTGDGAKPDSPQ 1070
                ADS +      + L +P             +  P                   +P 
Sbjct: 2037 PVTPADSPVIPVTPPDDLVVPVTPIDCPVVPVTLVDCP---------------VVSVTPA 2081

Query: 1071 KETLEVENQQEGGLKPLAQEHGPRSALGGARE--VPDAP---------PAACPEVSQARL 1119
               ++     +G + P+     P   +  A +  VP  P         PA  P V     
Sbjct: 2082 NSPVDPVTPADGPVVPVTPADSPVIPVTPADDLIVPVTPADSLIVSVTPADSPVVPVTPA 2141

Query: 1120 LSPAREERGLSGKSTPEPTLPSAVATEASLDSCPESSVGAVSSLDRGCPDAPAPTSA-PT 1178
             SP      +S  S   P +P   A    +   P    G V       P  PA + A P 
Sbjct: 2142 DSPV-----ISVASADSPVVPVTPADTVVVPVTPAD--GPV------IPVTPAESPAIPV 2188

Query: 1179 SQQPEPVLGLGSVEQPHEVPSVLGTPLLQPPENLAKGQPSTPVDRPLGPDPSAPGTLAGA 1238
            +    PV+ +   + P    +   +P++  P       P TP D P  P  SA G +   
Sbjct: 2189 TPADSPVVPVTPADDPVVPVTPADSPIVPVPPASDPVVPVTPADTPGSPVASADGPV--- 2245

Query: 1239 ALPPLEPPAPCLCQDPQEDSVEDEEPPGSLGLPPPQAGVQPAAAAVSGTTQPLGTGPRVS 1298
             +P     +P +   P +  V    P  S   P   A        ++       T     
Sbjct: 2246 -VPVTSADSPLVPVTPGDSPVVPVTPADSPVFPVTSADGPVFPVTLADDPVFPVTPADDP 2304

Query: 1299 LSPHSPLLSPKVASMDAKDLALQILPPCQVPPPSGPQSPAGPQG 1342
            + P SP  SP V    A       +P   VPP +G   P    G
Sbjct: 2305 IFPVSPADSPVVPVTPAN------IPVVPVPPANGSVVPVTSAG 2342



 Score = 80.9 bits (198), Expect = 9e-15
 Identities = 161/744 (21%), Positives = 253/744 (34%), Gaps = 87/744 (11%)

Query: 585  IVPRQAKEDLTLPQDSAMTPPLPLQDTDLSSAPKPVAAATIVSQQAEEGLTLPQDSVMTP 644
            +VP    +DL  P   A +P +P+   D    P   A   +V   +  G  +P     +P
Sbjct: 88   VVPVTPADDLVFPVTPADSPVIPVTSADDPVVPITPADNPVVPVTSANGPVIPVTPADSP 147

Query: 645  PLPLQDTELSSAPKPVAAATLVSQQAEEGLTLPQDSAMTPPLPLQDTDLSSAPKPVAAAT 704
              P+   +    P   A + +      +    P   A +P  P+   D ++ P   A   
Sbjct: 148  VFPVASADGPVVPVTPADSPVFPVTPADSPLFPVTPADSPLFPVTPADSAAIPVTPADGP 207

Query: 705  LVSQQAEEGLTLPQDSAMTPPLPLQDTDLSSAPKPVAAATLVSQQAEEGLTLPQDSAMTP 764
            +V      G  +P   A +P + +  TD    P   A   +V     +   +P  SA +P
Sbjct: 208  VVHVTPANGTVVPVTPADSPVVTVASTDSPVVPVTPADDPIVPVTPADSSFVPVISADSP 267

Query: 765  PLPL----------QDTDLSSAPK-PV--------AAATIVSQQAEEGLTLPQDSAMTPP 805
             +P+            TD+   P  PV        A  TI        L +   +A  P 
Sbjct: 268  FVPVIPADGPVVVDSSTDVLVVPVFPVNCILVPAFADETIXXXXXXXSLVVSVTTADDPI 327

Query: 806  LPLQDTD-----LSSAPKPVAAAT-----IVSQQAEEGLTLPQDSAMTPPLPLQDTD--- 852
            +P+   D     ++ A  PV   T      V     +G  +P   A +P +P+   D   
Sbjct: 328  VPVTPADSPVLSVTLADSPVVPVTPADSPFVPAIPADGPVVPVTPADSPVVPVTPADGPV 387

Query: 853  --LSSAPKPVAAATP-----VSQQAEEGLTLPQDSAMTPPLPLQDTD-----LSSAPKPV 900
              ++SA  P    TP     VS    +   +P  SA +P +P+   D     +++A  P+
Sbjct: 388  VSVASADSPFVPVTPADDPIVSVTPADSPVVPVTSADSPLIPVTTADGRVVPVTAAGDPI 447

Query: 901  AAATPVSQ-----QAEEGLTLPQDSAMTAPLPLQDTGPTSGP-EPLAVA---TPQTLQAE 951
               TP         + +G  +P  S   A +PL    P  GP  P+  A         A+
Sbjct: 448  VPVTPADTPGSPVTSADGPVVPVTS---ADIPLVPVTPPDGPVVPVTSADGPVAPVSSAD 504

Query: 952  AGCAPGTEPVATMAQQEVGEALGPRPAPEEKNAALPTVPEPAALDQVQQDDP-QPAAEAG 1010
                P T   +        + L     P +      T  E  A+     D P  P   A 
Sbjct: 505  GPVVPVTPADSPFIPVTTADDLIVPVTPADSPVLSVTPAESPAIPVTPADSPIVPVTPAN 564

Query: 1011 TPWAAQEDADSTLGMEALSLPE-PASGAGEEIAEALS-----RPGREACLEARAHTGDGA 1064
             P      ADS        +P  PA G    +  A S      P     L         A
Sbjct: 565  GPVVPVTSADSPF------VPVIPADGPVVPVTPADSPVVPVTPADSPVLSVTL-ADSPA 617

Query: 1065 KPDSPQKETLEVENQQEGGLKPLAQEHGPRSALGGARE-VPDAPPAACPEVSQARLLSPA 1123
             P +P    +      +G + P+A    P   +  A + +    PA  P +   +  SP 
Sbjct: 618  VPVTPADSPVVPVTPADGPVVPVASADSPFVPVTPADDPIVSVTPAESPAIPVTQADSPV 677

Query: 1124 REERGLSGKSTPEPTLPSAVATEASLDSCPESSVGAVSSLDRGCPDAPAPT-SAPTSQQP 1182
                 +   S   P +P    T A     P ++ G     D   P  PA T  +P +   
Sbjct: 678  -----VPVTSADRPVIP---VTTADGRIVPVTAAG-----DPIVPVTPADTPGSPVTSAD 724

Query: 1183 EPVLGLGSVEQPHEVPSVLGTPLLQPPENLAKGQPSTPVDRPLGPDPSAPGTLA--GAAL 1240
             PV+ + S + P    +    P++          P +  D P+ P  SA G +A   +A 
Sbjct: 725  GPVVPVTSADSPFVPVTPPDGPVVPVTSADGPVAPVSSADGPVVPVTSADGPVAPVSSAD 784

Query: 1241 PPLEPPAPCLCQDPQEDSVEDEEP 1264
             P+ P  P     P       + P
Sbjct: 785  GPVVPVTPADTNGPAVPVTSADSP 808



 Score = 74.3 bits (181), Expect = 8e-13
 Identities = 188/890 (21%), Positives = 305/890 (34%), Gaps = 148/890 (16%)

Query: 542  TAEKLPTPQEETSLTLCPDSPQNLKEEGGLDLPSGRKPVAAAT-----IVPRQAKEDLT- 595
            + + L  P   T   L PD    L ++  + +  G  PV   T     ++P    +D   
Sbjct: 2679 STDVLVVPVFPTDGILVPD----LADDPVVPVTPGDDPVVPVTPGDDPVIPVTPADDGPF 2734

Query: 596  LPQDSAMTPPLPLQDTDLSSAPKPVAAATIVSQQAEEGLTLPQDSVMTPPLPLQDTELSS 655
            +P   A+ P +P    D S  P  +    ++S   ++GL +P D+V     P       +
Sbjct: 2735 VPVTPAVGPVVPDLTADDSVVPDSLTDDPVISVCPDDGLVVP-DTVRDSDGPEVSVYPVT 2793

Query: 656  APKPVAAAT---LVSQQAEEGLTLPQDSAMTPPLPLQDTDLSSAPKPVAAATLVSQQAEE 712
             P    +A    +VS    +GL +       P +    T+    P PV    + S  + +
Sbjct: 2794 GPVVTDSAADCPVVSVPLTDGLVVLCPPDEVPAVHDSVTNGLVVPDPVIDGPVFSNPSVD 2853

Query: 713  GLTLPQDSAMTPPLPLQDTDLSSAPKPVAAATLVSQQAEE-------------------- 752
            G  +P  SA  P +P         PKP   + +V+    +                    
Sbjct: 2854 GPIVPVASADNPGVPDPIRAFPVVPKPSTFSPVVTSTPADWIDVIVTPADCADVPVNPVN 2913

Query: 753  GLTLPQDSAMTPPLPLQDTD-----------LSSAPKPVAAATIVSQQAEEGLTLPQDSA 801
            G  +P  S   P +P+  TD            +    PV    +V+  A +GL +P   A
Sbjct: 2914 GPVVPDLSGDCPVVPVPPTDDIVVLNPPDVVFAVVSTPVTDGPVVTDPATDGLMVPVTPA 2973

Query: 802  MTPPLPLQ-----DTDLSSA--------------PKPVAAATIVSQQAEEGLTLPQDSAM 842
                 P+      D  ++ A              P P A +++VS    +GL +P     
Sbjct: 2974 NGSVAPVTLSEYPDVTVTPADGTVVSPTIGGPVVPDPSADSSVVSNPTTDGLIVPNPLLA 3033

Query: 843  TPPLPLQDTDLSSAPKPVAAATPVSQQAEEGLTLPQDSAMTPPLPLQDTDLSSAPKPVAA 902
             P +P+  TD   AP  +A    V+    +G  +   +   P  P    +      P   
Sbjct: 3034 GPVVPVTPTDGPLAPVILADCPDVTVTPADGPVVCAFTTGGPVFPDPTAEGLVVSNPTVD 3093

Query: 903  ATPVSQQAEEGLTLPQDSAMTAPLPLQDTGPTSGPEPLAVATPQTLQAEAGCAPGTEPVA 962
               V+  + +GL     SA  A        P   P+ L       L  ++     T    
Sbjct: 3094 DPVVTNPSTKGLV----SATPADCADVPVIPADCPDVLV-----NLVNDSVVPDFTADWT 3144

Query: 963  TMAQQEVGEALGPRPAPEEKNAALPTVPEPAALDQVQQDDPQPAAEAGTPWAAQEDAD-- 1020
             ++     + + P P  E     +P    P   D            AG P       D  
Sbjct: 3145 VVSVSPPDDLVAPDPPDEVPVVLVPITDGPVVPDLTTDGLVVSVTPAGAPVVPVFLTDCP 3204

Query: 1021 --STLGMEALSLPEPASGAGEEIAEALSRPGREACLEARAHTGDGAKPDSPQKETLEVEN 1078
              +    ++  +P+P+S  G  +A++L   G    L       D   PDSP    +  + 
Sbjct: 3205 DVTVTPADSPVVPDPSSD-GPVVADSLDDDG----LVPVTPADDSVVPDSPANGLVVPDP 3259

Query: 1079 QQEGGLKPLAQEHGPRSALGGAREVPDAPP-----AACPEVSQARL--LSPAREERG--- 1128
              +G + P     GP   +  A    DAP      A CP+V+      L  +  +RG   
Sbjct: 3260 TTDGPVAPDPSVDGPVVPVTPA----DAPTVSVTLADCPDVTVTPPDGLVVSDSKRGGPV 3315

Query: 1129 LSGKSTPEPTLPSAVATEASLDSCPESSVGAVSSLDRGCPDAPAPTSAPTSQQ------- 1181
            ++G ST +P + +  A  + +   P +    V      CPD P    +P           
Sbjct: 3316 VTGLSTNDPVITATPADFSDVTVTP-ADFEDVPVTPANCPDVPVNPESPVVSDLAVDFLV 3374

Query: 1182 --PEPVLGLGSVEQPHEVPSVLGTPLLQPPENLAKG-QPSTPV-DRPLGPDPSAPGTL-- 1235
                P   L  +E P +VP V        P+ ++ G   S P+ +     DPS  G++  
Sbjct: 3375 VPVVPSDDLVVLEPPDKVPVV--------PDPISNGLVVSDPITNNTAATDPSVDGSVVP 3426

Query: 1236 AGAALPPLEPPAPCLCQD----PQEDSVEDEEPPGSLGLPPPQAGVQPAAAAVSGTTQPL 1291
               A  P+ P     C D    P +DSV  +                   A        +
Sbjct: 3427 VSPADGPVAPVTLADCPDVTITPADDSVVSD---------------SKIRAEFEDVPVTI 3471

Query: 1292 GTGPRVSLSPHS-PLLSPKVASMDAKDLALQILPPCQVPPPSGPQSPAGP 1340
               P V ++P S P++S         DLA+   P   +PPP    +P  P
Sbjct: 3472 ADCPNVPVNPKSGPVVS---------DLAVD-CPVVPIPPPDDLVAPEPP 3511



 Score = 72.4 bits (176), Expect = 3e-12
 Identities = 173/878 (19%), Positives = 295/878 (33%), Gaps = 120/878 (13%)

Query: 548  TPQEETSLTLCP-DSPQNLKEEGGLDLPSGRKPVAAATIV-----PRQAKEDLTLPQDSA 601
            TP ++  + + P DSP        + +P    PV   T       P  + +   +P  SA
Sbjct: 2199 TPADDPVVPVTPADSPI-------VPVPPASDPVVPVTPADTPGSPVASADGPVVPVTSA 2251

Query: 602  MTPPLPLQDTDLSSAPKPVAAATIVSQQAEEGLTLP---QDSVMTPPLPLQDT--ELSSA 656
             +P +P+   D    P   A + +    + +G   P    D  + P  P  D    +S A
Sbjct: 2252 DSPLVPVTPGDSPVVPVTPADSPVFPVTSADGPVFPVTLADDPVFPVTPADDPIFPVSPA 2311

Query: 657  PKPVAAAT-----LVSQQAEEGLTLPQDSAMTPPLPLQDTDLSSAPKPVAAATLVSQQAE 711
              PV   T     +V      G  +P  SA +P +P+   D            +V     
Sbjct: 2312 DSPVVPVTPANIPVVPVPPANGSVVPVTSAGSPFVPIIPADGLVVLDSSTDVLVVLVSPT 2371

Query: 712  EGLTLPQ---------DSAMTPPLPLQDTDLSSAPKPVAAATLVSQQAEEGLTLPQDSAM 762
            +G+ +P           ++ +P +P+  TD    P   A   +V   + +   +P   A 
Sbjct: 2372 DGIPVPDLADDPVVSVTTSDSPVIPVTPTDSPVVPVAPADGPVVPVTSVDSPVVPVTPAD 2431

Query: 763  TPPLPLQDTDLSSAPKPVAAATIVSQQAEEGLTLPQDSAMTPPLPLQDTDLSSAPKPVAA 822
            +P +P+   D    P   A   +VS    +G  +P  +A  P + +   D    P   A 
Sbjct: 2432 SPVIPVTPADSLVVPATPADDPVVSVTPADGPVVPVTTADIPVISVTSADSPVVPVTPAD 2491

Query: 823  ATIVSQQAEEGLTLPQDSAMTPPLPLQDTDLSSAPKPVAAATPVSQQAEEGLTLPQDSAM 882
              +V   + + + +P   A  P +P+   D      P+   TP        +++  D   
Sbjct: 2492 GLVVPVTSADSVVVPATPADCPLVPVDPAD-----SPIVLFTPYDNPV---VSVTSDD-- 2541

Query: 883  TPPLPLQDTDLSSAPKPVAAATPVSQQAEEGLTLPQDSAMTAPLPLQDTGPTSGPEPLAV 942
            +P  P+   D S  P   A    V     +G  +P   A +  +P+     TS   P+  
Sbjct: 2542 SPVFPVTPADSSVVPVTPAGVPVVPVTPGDGPVVPVTPADSLVVPV-----TSADSPVFP 2596

Query: 943  ATPQTLQAEAGCAPGTEPVATMAQQEVGEALGPRPAPEEKNAALPTVPEPAALDQVQQDD 1002
             TP    A++   P +     +     G++     +P +    L T  +   +     + 
Sbjct: 2597 VTP----ADSPVFPVSPADDLVVPVTPGDSPVVPVSPADSPVVLVTPADGPVVPVTPANG 2652

Query: 1003 P-QPAAEAGTPWAAQEDADSTLGMEALS--LPEPASGAGEEIAEALSRPGREACLEARAH 1059
            P  P   A +P+     AD  + +++ +  L  P       +   L+    +  +     
Sbjct: 2653 PVVPVTSADSPFVPVIPADGLVVLDSSTDVLVVPVFPTDGILVPDLA----DDPVVPVTP 2708

Query: 1060 TGDGAKPDSPQKE-TLEVENQQEGGLKPLAQEHGP--RSALGGAREVPDAPP-----AAC 1111
              D   P +P  +  + V    +G   P+    GP           VPD+       + C
Sbjct: 2709 GDDPVVPVTPGDDPVIPVTPADDGPFVPVTPAVGPVVPDLTADDSVVPDSLTDDPVISVC 2768

Query: 1112 PEVSQARLLSPAREERGLSGKSTPEPTLPSAVATEASLDSCPESSVGAVSSLDRGCPDAP 1171
            P+      L      R   G       +   V T+++ D CP  SV     L   CP   
Sbjct: 2769 PDDG----LVVPDTVRDSDGPEVSVYPVTGPVVTDSAAD-CPVVSVPLTDGLVVLCPPDE 2823

Query: 1172 APT----------------SAPTSQQPE---PVLGLGSVEQPHEVPSVLGTPLLQPPENL 1212
             P                   P    P    P++ + S + P     +   P++  P   
Sbjct: 2824 VPAVHDSVTNGLVVPDPVIDGPVFSNPSVDGPIVPVASADNPGVPDPIRAFPVVPKPSTF 2883

Query: 1213 AKGQPSTPVD------RPLGPDPSAPGTLAGAALPPLEPPAPCLCQDPQEDSVEDEEP-- 1264
            +    STP D       P          + G  +P L    P +   P +D V    P  
Sbjct: 2884 SPVVTSTPADWIDVIVTPADCADVPVNPVNGPVVPDLSGDCPVVPVPPTDDIVVLNPPDV 2943

Query: 1265 ----------PGSLGLPPPQAGVQPAAAAVSGTTQP--LGTGPRVSLSPH-----SPLLS 1307
                       G +   P   G+       +G+  P  L   P V+++P      SP + 
Sbjct: 2944 VFAVVSTPVTDGPVVTDPATDGLMVPVTPANGSVAPVTLSEYPDVTVTPADGTVVSPTIG 3003

Query: 1308 PKVASMDAKDLALQILPPCQ---VPPP--SGPQSPAGP 1340
              V    + D ++   P      VP P  +GP  P  P
Sbjct: 3004 GPVVPDPSADSSVVSNPTTDGLIVPNPLLAGPVVPVTP 3041



 Score = 67.4 bits (163), Expect = 1e-10
 Identities = 190/873 (21%), Positives = 284/873 (32%), Gaps = 173/873 (19%)

Query: 579  PVAAAT--IVPRQAKEDLTLPQDSAMTPPLPLQDTD------------------------ 612
            PV +A   ++P    +    P  SA  P +P+   D                        
Sbjct: 130  PVTSANGPVIPVTPADSPVFPVASADGPVVPVTPADSPVFPVTPADSPLFPVTPADSPLF 189

Query: 613  ----LSSAPKPVAAA--TIVSQQAEEGLTLPQDSVMTPPLPLQDTELSSAPKPVAAATLV 666
                  SA  PV  A   +V      G  +P     +P + +  T+    P   A   +V
Sbjct: 190  PVTPADSAAIPVTPADGPVVHVTPANGTVVPVTPADSPVVTVASTDSPVVPVTPADDPIV 249

Query: 667  SQQAEEGLTLPQDSAMTPPLPL----------QDTDLSSAPKPVAAATLVSQQAEE---- 712
                 +   +P  SA +P +P+            TD+   P       LV   A+E    
Sbjct: 250  PVTPADSSFVPVISADSPFVPVIPADGPVVVDSSTDVLVVPVFPVNCILVPAFADETIXX 309

Query: 713  -----GLTLPQDSAMTPPLPLQDTD-----LSSAPKPVAAAT-----LVSQQAEEGLTLP 757
                  L +   +A  P +P+   D     ++ A  PV   T      V     +G  +P
Sbjct: 310  XXXXXSLVVSVTTADDPIVPVTPADSPVLSVTLADSPVVPVTPADSPFVPAIPADGPVVP 369

Query: 758  QDSAMTPPLPLQDTD-----LSSAPKPVAAAT-----IVSQQAEEGLTLPQDSAMTPPLP 807
               A +P +P+   D     ++SA  P    T     IVS    +   +P  SA +P +P
Sbjct: 370  VTPADSPVVPVTPADGPVVSVASADSPFVPVTPADDPIVSVTPADSPVVPVTSADSPLIP 429

Query: 808  LQDTDLSSAPKPVAAATIVSQQAEEGLTLPQDSAMTPPLPLQDTDLSSAP--KPVAAATP 865
            +   D    P   A   IV     +    P  SA  P +P+   D+   P   P     P
Sbjct: 430  VTTADGRVVPVTAAGDPIVPVTPADTPGSPVTSADGPVVPVTSADIPLVPVTPPDGPVVP 489

Query: 866  VSQ--------QAEEGLTLPQDSAMTPPLPLQDTD-----LSSAPKPVAAATPVSQQAEE 912
            V+          + +G  +P   A +P +P+   D     ++ A  PV + TP    A  
Sbjct: 490  VTSADGPVAPVSSADGPVVPVTPADSPFIPVTTADDLIVPVTPADSPVLSVTPAESPAIP 549

Query: 913  GLTLPQDSAMTAPLPLQDTGP----TSGPEPLAVATPQTLQAEAGCAPGTE------PVA 962
                P DS +    P    GP    TS   P     P    A+    P T       PV 
Sbjct: 550  --VTPADSPIVPVTPA--NGPVVPVTSADSPFVPVIP----ADGPVVPVTPADSPVVPVT 601

Query: 963  TMAQQEVGEALGPRPAPEEKNAALPTVPEPAALDQVQQDDP-QPAAEAGTPWAAQEDAD- 1020
                  +   L   PA     A  P VP   A      D P  P A A +P+     AD 
Sbjct: 602  PADSPVLSVTLADSPAVPVTPADSPVVPVTPA------DGPVVPVASADSPFVPVTPADD 655

Query: 1021 ---STLGMEALSLP--------EPASGAGEEIAEALSRPGREACLEARAHTGDGAKPDSP 1069
               S    E+ ++P         P + A   +    +  GR   + A    GD   P +P
Sbjct: 656  PIVSVTPAESPAIPVTQADSPVVPVTSADRPVIPVTTADGRIVPVTA---AGDPIVPVTP 712

Query: 1070 QKETLEVENQQEGGLKPLAQEHGPRSALGGAREVPDAPPAACPEVSQARLLSPAREERGL 1129
                       +G + P+     P         VP  PP   P V       P       
Sbjct: 713  ADTPGSPVTSADGPVVPVTSADSP--------FVPVTPPDG-PVVPVTSADGPVAPVSSA 763

Query: 1130 SGKSTPEPTLPSAVATEASLDSCPESSVGAVSSLDRGCPDAPAPTSAPTSQQPEPVLGLG 1189
             G   P  +    VA  +S D       G V       P  PA T+        P + + 
Sbjct: 764  DGPVVPVTSADGPVAPVSSAD-------GPV------VPVTPADTNG-------PAVPVT 803

Query: 1190 SVEQPHEVPSVLGTPLLQPPENLAKGQPSTPVDRPLGPDPSAPGTLAGAALPPLEPPAPC 1249
            S + P        +P++          P TP D P+ P   A  +     +P +   +P 
Sbjct: 804  SADSPFVPVIPADSPVV----------PVTPADDPIVPVTPADSSF----VPVISADSPF 849

Query: 1250 LCQDPQEDSVEDEEPPGSLGLP--PPQAGVQPAAAAVSGTTQPLGTGPRVSLSPHSPLLS 1307
            +   P +  V  +     L +P  P    + PA A  +         P + ++P   L+ 
Sbjct: 850  VPVIPADGPVVVDSSTDVLVVPVFPVNCILVPAFADETVVPLNPADSPVIPVTPPDDLVV 909

Query: 1308 PKVASMDAKDLALQILPPCQVPPPSGPQSPAGP 1340
            P V   D   +A      C V P +   SPA P
Sbjct: 910  P-VTPTDC-PVAPVTSADCPVVPVTPADSPADP 940



 Score = 65.5 bits (158), Expect = 4e-10
 Identities = 194/927 (20%), Positives = 310/927 (33%), Gaps = 112/927 (12%)

Query: 479  STATVTPHTLQVAPGLQVEVA--TRVTPQAGEEETDSTAGQESAAMAMPQPSQEGI---S 533
            +  +V P TL   P + V  A  T V+P  G       +   S    +  P+ +G+   +
Sbjct: 2973 ANGSVAPVTLSEYPDVTVTPADGTVVSPTIGGPVVPDPSADSSV---VSNPTTDGLIVPN 3029

Query: 534  EILGQESVTAEKLPTPQEETSLTLCPDSPQNLKE--------EGGLDLPSGRKPVAAATI 585
             +L    V       P     L  CPD      +         GG   P    P A   +
Sbjct: 3030 PLLAGPVVPVTPTDGPLAPVILADCPDVTVTPADGPVVCAFTTGGPVFPD---PTAEGLV 3086

Query: 586  VPRQAKED--LTLPQDSAMTPPLPLQDTDLSSAPK--PVAAATIVSQQAEEGLTL----- 636
            V     +D  +T P    +    P    D+   P   P     +V+       T      
Sbjct: 3087 VSNPTVDDPVVTNPSTKGLVSATPADCADVPVIPADCPDVLVNLVNDSVVPDFTADWTVV 3146

Query: 637  ---PQDSVMTPPLPLQDTELSSAPKPVAAATLVSQQAEEGLTLPQDSAMTPPLPLQDTDL 693
               P D ++ P  P    E+     P+    +V     +GL +    A  P +P+  TD 
Sbjct: 3147 SVSPPDDLVAPDPP---DEVPVVLVPITDGPVVPDLTTDGLVVSVTPAGAPVVPVFLTDC 3203

Query: 694  SSAPKPVAAATLVSQQAEEGLTLPQ---DSAMTPPLPLQDTDLSSAPKPVAAATLVSQQA 750
                   A + +V   + +G  +     D  + P  P  D+ +  +P   A   +V    
Sbjct: 3204 PDVTVTPADSPVVPDPSSDGPVVADSLDDDGLVPVTPADDSVVPDSP---ANGLVVPDPT 3260

Query: 751  EEGLTLPQDSAMTPPLPLQDTDLSSAPKPVAAATIVSQQAEEGLTLPQDSAMTPP---LP 807
             +G   P  S   P +P+   D  +    +A    V+    +GL +       P    L 
Sbjct: 3261 TDGPVAPDPSVDGPVVPVTPADAPTVSVTLADCPDVTVTPPDGLVVSDSKRGGPVVTGLS 3320

Query: 808  LQDTDLSSAPKPVAAATIVSQQAEEGLTLPQDSAMTPPLPLQ-DTDLSSAPKPVAAATPV 866
              D  +++ P   +  T+     E+   +P   A  P +P+  ++ + S         PV
Sbjct: 3321 TNDPVITATPADFSDVTVTPADFED---VPVTPANCPDVPVNPESPVVSDLAVDFLVVPV 3377

Query: 867  SQQAEEGLTLPQDSAMTPPLPLQDTDLSSAPKPVAAATPVSQQAEEGLTLPQDSA--MTA 924
                +  +  P D     P P+ +  + S   P+   T  +  + +G  +P   A    A
Sbjct: 3378 VPSDDLVVLEPPDKVPVVPDPISNGLVVS--DPITNNTAATDPSVDGSVVPVSPADGPVA 3435

Query: 925  PLPLQDTGP-TSGPEPLAVATPQTLQAEAGCAPGTEPVATMAQQEVGEALGPRPAPEEKN 983
            P+ L D    T  P   +V +   ++AE    P T  +A      V    GP     +  
Sbjct: 3436 PVTLADCPDVTITPADDSVVSDSKIRAEFEDVPVT--IADCPNVPVNPKSGP--VVSDLA 3491

Query: 984  AALPTVPEPAALDQVQQDDPQPAAEAGTPWAAQEDADSTLGMEALSLPEPASGAG-EEIA 1042
               P VP P   D V    P+P  E   P       DS +  + ++    AS    + I 
Sbjct: 3492 VDCPVVPIPPPDDLVA---PEPPDEV--PVVPDPITDSLVVSDPMTDGPVASDPSIDGIV 3546

Query: 1043 EALSRPGREACLEARAHTGDGAKPDSPQKETLEVENQQEGGLKPLAQEHGPRSALGGARE 1102
              +  P     L++ A       PD+     +      +G +                  
Sbjct: 3547 VPVVSPSGLLVLDSVADVS--ILPDTSADVPVTPVTLADGSV------------------ 3586

Query: 1103 VPDAPPAACPEVSQARLLSPAREERGLSGKSTPEPTLPSAVATEASLDSCPESSVGAVSS 1162
            VPD+ P  CP V           +  + G   P P     V  + + D     S+     
Sbjct: 3587 VPDSAPD-CPVVPVLPTDGFVVLDLLVDGVVVPNPADVGPVVPDPTTDG--PDSIKDFPL 3643

Query: 1163 LDRGCPDAPAPTSAPTSQQPEPVLGLGSVEQPHEVPSVLG---TPLLQPPENLAKGQPST 1219
            +    PD P     P ++   PV+ L S      VP   G     L+ P +NL    P  
Sbjct: 3644 VPDPWPDCPV---VPVTRTDGPVV-LDSSADGVVVPVTPGDDSVALVTPTDNLVV--PDL 3697

Query: 1220 PVDRPLGPDPSAPG-----TLAGAALPPLEPPAPCLCQDPQEDSVEDEEPPGSLGLPPPQ 1274
              D P+ PDPSA G     +LA   L P  P    +  +   D+    +P     L P  
Sbjct: 3698 TTDGPVVPDPSADGPVVLVSLADDLLVPNPPVKDTVVPNSVADNPVALDPVTDCPLVP-- 3755

Query: 1275 AGVQPAAAAVSGTTQPLGTGPRVSLSPHSPLLSPKVASMDAKDLALQILPPCQVPPPSGP 1334
               +P+A  +   T  L  GP V   P      P V + +   L   ++P      P  P
Sbjct: 3756 ---EPSANGLV-VTDSLDEGPVV---PDPSADDPVVLNPETNGL---VVPDISANGPVVP 3805

Query: 1335 QSPA-GPQGLSAPEQQEDEDSLEEDSP 1360
             +P  G      P+   +      D P
Sbjct: 3806 DTPTDGSDATVTPDDCSEVFVTATDGP 3832



 Score = 50.1 bits (118), Expect = 2e-05
 Identities = 79/362 (21%), Positives = 122/362 (33%), Gaps = 51/362 (14%)

Query: 547  PTPQEETSLTLCPDSPQNLKEEGGLDLPSGRKPVAAATIVPRQAKEDLTLPQDSAMTPPL 606
            P P +E  +   P +   +  +   D P    P     +VP  +   L +    A    L
Sbjct: 3508 PEPPDEVPVVPDPITDSLVVSDPMTDGPVASDPSIDGIVVPVVSPSGLLVLDSVADVSIL 3567

Query: 607  PLQDTDLSSAPKPVAAATIVSQQAEEGLT---LPQDSVMTPPLPLQDTELSSAPKPVAAA 663
            P    D+   P  +A  ++V   A +      LP D  +   L +    +   P P    
Sbjct: 3568 PDTSADVPVTPVTLADGSVVPDSAPDCPVVPVLPTDGFVVLDLLVDGVVV---PNPADVG 3624

Query: 664  TLVSQQAEEGLTLPQDSAMTPP-------LPLQDTD----LSSAPKPVAAATLVSQQAEE 712
             +V     +G    +D  + P        +P+  TD    L S+   V         +  
Sbjct: 3625 PVVPDPTTDGPDSIKDFPLVPDPWPDCPVVPVTRTDGPVVLDSSADGVVVPVTPGDDSV- 3683

Query: 713  GLTLPQDSAMTPPLPLQDTDLSSAPKPVAAATLVSQQAEEGLTLPQ---------DSAMT 763
             L  P D+ + P L    TD    P P A   +V     + L +P          +S   
Sbjct: 3684 ALVTPTDNLVVPDLT---TDGPVVPDPSADGPVVLVSLADDLLVPNPPVKDTVVPNSVAD 3740

Query: 764  PPLPLQD-TDLSSAPKPVAAATIVSQQAEEGLTLPQDSAMTPPLPLQDTDLSSAPKPVAA 822
             P+ L   TD    P+P A   +V+   +EG  +P  SA  P                  
Sbjct: 3741 NPVALDPVTDCPLVPEPSANGLVVTDSLDEGPVVPDPSADDP------------------ 3782

Query: 823  ATIVSQQAEEGLTLPQDSAMTPPLPLQDTDLSSAPKPVAAATPVSQQAEEGLTLPQDSAM 882
              +V      GL +P  SA  P +P   TD S A       + V   A +G  +  D  +
Sbjct: 3783 --VVLNPETNGLVVPDISANGPVVPDTPTDGSDATVTPDDCSEVFVTATDGPDVVSDCPI 3840

Query: 883  TP 884
             P
Sbjct: 3841 VP 3842


>gi|150418009 transforming, acidic coiled-coil containing protein 2
            isoform a [Homo sapiens]
          Length = 2948

 Score = 86.7 bits (213), Expect = 2e-16
 Identities = 314/1414 (22%), Positives = 471/1414 (33%), Gaps = 205/1414 (14%)

Query: 126  CQALLSPRAARTALRDQEGGHASPDPPPELCSQGDLSVPSPPPD-----PDSFFTPPSTP 180
            C A  S  +    L   E      DP      +G L +PSPPP      P S       P
Sbjct: 59   CTASESSASLDPCLVSPEVTEPRKDPQGARGPEGSL-LPSPPPSQEREHPSSSMPFAECP 117

Query: 181  TKTTYALLPACGPHGDARDSEAELRDELLDSP----PASPSGSYITADGDSWASSPSCSL 236
             +   A  PA  P  D   +++  R+   ++P     A P+    +      A+ PS   
Sbjct: 118  PEGCLAS-PAAAPE-DGPQTQSPRREPAPNAPGDIAAAFPAERDSSTPYQEIAAVPSAGR 175

Query: 237  SLLAPAEG----LDFPSGWGLSPQGSMVDERELHPA---GTPEPPSSESSLSADSSSSWG 289
                  EG      F SG   SP  S V  RE   A   G  + P    S   +++  + 
Sbjct: 176  ERQPKEEGQKSSFSFSSGIDQSPGMSPVPLREPMKAPLCGEGDQPGGFESQEKEAAGGFP 235

Query: 290  QEGHFFDLDFLANDPMIPAALLPFQGSLIFQVEAVEVTPLSPEEEEEEAVADPDPGGDLA 349
                   +  +   P  PAA    QG+     E+  V   SP +       DP P     
Sbjct: 236  PAESRQGVASVQVTPEAPAAAQ--QGT-----ESSAVLEKSPLKPMAPIPQDPAPRASDR 288

Query: 350  GEGEEDSTSASFLQSLSDLSITEGMDEAFAFRDDTSAASSDSDSASYAEADDERLYSGEP 409
              G+ ++        L      E +      R ++ AA     +A+  E+  + + +  P
Sbjct: 289  ERGQGEAPPQYLTDDL------EFLRACHLPRSNSGAAPEAEVNAASQESCQQPVGAYLP 342

Query: 410  HAQATLLQDSVQKTEEESGGGAKGLQAQDGTVSWAVEAAPQTSDRGAYLSQRQELISEVT 469
            HA+      S     E  G G + L   D      V+  PQT  RG   +Q   + +   
Sbjct: 343  HAELPWGLPSPALVPEAGGSGKEALDTID------VQGHPQTGMRGTKPNQVVCVAAGGQ 396

Query: 470  EEGLALGQESTATVTP-------HTLQVAPGLQVEVATRVTPQAGEEETDSTAGQESAAM 522
             EG        + +TP        +L   P  Q+ +A    P +   E+ S AG   +A 
Sbjct: 397  PEGGLPVSPEPSLLTPTEEAHPASSLASFPAAQIPIAVE-EPGSSSRESVSKAGMPVSAD 455

Query: 523  AMPQPSQEGISEILGQESVTAEKLPTPQEETSLTLCPDSPQNLKEEGGLDLPSGRKPVAA 582
            A  +    G+  +  Q S    K   P+ +      P SPQ   E    +     +P   
Sbjct: 456  AAKEVVDAGLVGLERQVSDLGSKGEHPEGDPGEVPAP-SPQERGEHLNTEQSHEVQPGVP 514

Query: 583  ATIVPRQAKEDLTLPQDSAMTPPLPLQDTDLSSAPK-PVAAATIVSQQ-----AEEGLTL 636
               +P++   ++   Q  A  PPLP   ++ +  P  P   A +         A+EG   
Sbjct: 515  PPPLPKEQSHEV---QPGAPPPPLPKAPSESARGPPGPTDGAKVHEDSTSPAVAKEGSRS 571

Query: 637  PQDS------VMTPP-------LPLQDTE-LSSAPKPVAAATLVSQQAEEGLTLPQDSAM 682
            P DS         PP       L  +D++  SS   P      +S+ + +  +    S+ 
Sbjct: 572  PGDSPGGKEEAPEPPDGGDPGNLQGEDSQAFSSKRDPEVGKDELSKPSSDAESRDHPSSH 631

Query: 683  TPPLPLQD----TDLSSAPKPVAAAT-LVSQQAEEGLTLPQ--DSAMTPPLPLQDTDLSS 735
            +   P +     TD   +    A A+ L  +  EE   LP   D A  P +P       S
Sbjct: 632  SAQPPRKGGAGHTDGPHSQTAEADASGLPHKLGEEDPVLPPVPDGAGEPTVPEGAIWEGS 691

Query: 736  APKPVAAATLVSQQA----EEGLTLPQDSAMTPPLPLQDTDLSSAPKPVAAATIVSQQAE 791
              +P    TL S++     E  LTL  + +  PP P+ +     APK     + +  +  
Sbjct: 692  GLQPKCPDTLQSREGLGRMESFLTLESEKSDFPPTPVAEV----APKAQEGESTLEIRKM 747

Query: 792  -----EGLTLPQDSAMTPPLPLQDTDL-SSAPKPVAAATIVSQQAEEGLTLPQDSAMTPP 845
                 EGL    D    P       +  +  P P     + +      L L QD    P 
Sbjct: 748  GSCDGEGLLTSPDQPRGPACDASRQEFHAGVPHPPQGENLAADLGLTALILDQDQQGIPS 807

Query: 846  LP-------------LQDTDLSSAPKPVAAATPVSQQAEEGLTLPQDSAMTPP----LPL 888
             P             L  ++    P      T +    +E    P++   T P       
Sbjct: 808  CPGEGWIRGAASEWPLLSSEKHLQPSQAQPETSIFDVLKEQAQPPENGKETSPSHPGFKD 867

Query: 889  QDTDLSSAPKPVAAATPVSQQAEEGLTLPQDSAMTAPLP---LQDTGPTSGPEPLAVATP 945
            Q  D S    PV      +     G      S + + LP   L DT PTS P  +   + 
Sbjct: 868  QGADSSQIHVPVEPQEDNNLPTHGGQEQALGSELQSQLPKGTLSDT-PTSSPTDMVWESS 926

Query: 946  QTLQAEAGCAPGTEPVATMAQQEVGEALG--------PRPAPEEKNAAL----------- 986
             T ++E   AP  + +  + ++    A G        P  A   K+ +L           
Sbjct: 927  LTEESELS-APTRQKLPALGEKRPEGACGDGQSSRVSPPAADVLKDFSLAGNFSRKETCC 985

Query: 987  ----PTVPEPAALDQVQQDDPQPAAEAGTPWAAQEDADSTLGMEALSLPEPASGAGEEIA 1042
                P   + A  D +++      A    P  A E AD    +  LS  E ASG   E  
Sbjct: 986  TGQGPNKSQQALADALEEGSQHEEACQRHP-GASEAADGCSPLWGLSKREMASGNTGEAP 1044

Query: 1043 ----EALSRPGREACLEARAHTGDGAKPDSPQKETLEVENQQEGGLKPLAQEHGPRSALG 1098
                ++++      CL A A    G  P     ET   +  QEG  +P+           
Sbjct: 1045 PCQPDSVALLDAVPCLPALAPASPGVTPTQDAPETEACDETQEGRQQPVPAPQQKMECWA 1104

Query: 1099 GAREVPDAPPAACPEVSQARLLSPAREERGLSGKSTP----------EPTLP-SAVATEA 1147
             +        A+ P   +    + A E  G +G   P          E TL    + TE 
Sbjct: 1105 TSDAESPKLLASFPSAGEQGGEAGAAETGGSAGAGDPGKQQAPEKPGEATLSCGLLQTEH 1164

Query: 1148 SLDSCPESSVGAVSSLDRGCPDAPAPTSAPTSQQPEPVLG-----LGSVEQPHEVPSVLG 1202
             L S  E+S    S+L   C       S   +  P   LG              VP    
Sbjct: 1165 CLTSGEEAS---TSALRESCQAEHPMASCQDALLPARELGGIPRSTMDFSTHQAVPDPKE 1221

Query: 1203 TPLLQPPENLAKGQPSTPVDRPLGPDPSAPGTLAGAALPPLEP-PAPCLCQDPQ---EDS 1258
              L  PPE  A   P   VD          G  A ++  P  P  +PC   +P    E++
Sbjct: 1222 LLLSGPPEVAAPDTPYLHVDSAAQRGAEDSGVKAVSSADPRAPGESPCPVGEPPLALENA 1281

Query: 1259 VEDEEPPGSLG--LPPPQAGVQ-PAAAAVSGTTQPLGTGPRVSLSPHSPLLSPKVASMDA 1315
               +   GSL   L P  AG + PA  A SG             SP +      V SM  
Sbjct: 1282 ASLKLFAGSLAPLLQPGAAGGEIPAVQASSG-------------SPKARTTEGPVDSMPC 1328

Query: 1316 KDLALQILPPCQVPPPSGPQSPAGPQGLSAPEQQEDEDSLEEDSPRALGSGQHSDSHGES 1375
             D  + +L         G Q+    +  +AP              +A G G   D+ GE+
Sbjct: 1329 LD-RMPLL-------AKGKQATGEEKAATAPGA----------GAKASGEGMAGDAAGET 1370

Query: 1376 SAELDEQDILAPQTVQCPAQAPAGG---SEETIA 1406
               ++       +  Q P Q  +GG   S E IA
Sbjct: 1371 EGSMERMG----EPSQDPKQGTSGGVDTSSEQIA 1400



 Score = 53.9 bits (128), Expect = 1e-06
 Identities = 328/1550 (21%), Positives = 524/1550 (33%), Gaps = 269/1550 (17%)

Query: 47   PGPSHLALTFLPSKPGARPQPEGASWDAGPGGAPSAWADPGEGGPSPMLLPEGLSSQALS 106
            PGP+  A     S   A  +    S    PGG   A   P  G P  +   +G  SQA S
Sbjct: 547  PGPTDGAKVHEDSTSPAVAKEGSRSPGDSPGGKEEAPEPPDGGDPGNL---QGEDSQAFS 603

Query: 107  TEAPLPATLEPRIVMGEETCQALLSPRAARTALRDQEGGHASPDPPPELCSQGDLSV--- 163
            ++   P   +  +       ++   P ++ +A   ++GG    D P    ++ D S    
Sbjct: 604  SKRD-PEVGKDELSKPSSDAESRDHP-SSHSAQPPRKGGAGHTDGPHSQTAEADASGLPH 661

Query: 164  ------PSPPPDPDSFFTP--PSTPTKTTYALLPACGPHGDARD------SEAELRDELL 209
                  P  PP PD    P  P         L P C     +R+      S   L  E  
Sbjct: 662  KLGEEDPVLPPVPDGAGEPTVPEGAIWEGSGLQPKCPDTLQSREGLGRMESFLTLESEKS 721

Query: 210  DSPPASPSGSYITA-DGDSWASSPSCSLSLLAPAEG---LDFPSGWGLSPQGSMVD--ER 263
            D PP   +     A +G+S     +  +  +   +G   L  P      P+G   D   +
Sbjct: 722  DFPPTPVAEVAPKAQEGES-----TLEIRKMGSCDGEGLLTSPD----QPRGPACDASRQ 772

Query: 264  ELHPAGTPEPPSSESSLSADSSSSWGQEGHFFDLDFLANDPMIPAALLPFQGSLIFQVEA 323
            E H AG P PP  E+ L+AD     G      D D       IP+   P +G +  +  A
Sbjct: 773  EFH-AGVPHPPQGEN-LAADL----GLTALILDQD----QQGIPSC--PGEGWI--RGAA 818

Query: 324  VEVTPLSPEEEEEEAVADPDPG-GDLAGEGEEDSTSASFLQSLSDLSITEGMDEAFAFRD 382
             E   LS E+  + + A P+    D+  E  +   +             E       F+D
Sbjct: 819  SEWPLLSSEKHLQPSQAQPETSIFDVLKEQAQPPENGK-----------ETSPSHPGFKD 867

Query: 383  DTSAASSDSDSASYAEADDERLYSGEPHAQATLLQDSVQKTEEESGGGAKGLQAQDGTVS 442
              + +S         E ++   + G+  A  + LQ  + K                GT+S
Sbjct: 868  QGADSSQIHVPVEPQEDNNLPTHGGQEQALGSELQSQLPK----------------GTLS 911

Query: 443  WAVEAAPQTSDRGAYLSQRQELISEVTEEGLALGQESTATVTPHTLQVAPGLQVEVATRV 502
                ++P      + L++  EL +   ++  ALG++                    ++RV
Sbjct: 912  DTPTSSPTDMVWESSLTEESELSAPTRQKLPALGEKRPEGACGDGQ----------SSRV 961

Query: 503  TPQAGEEETD-STAGQESAAMAM-----PQPSQEGISEILGQESVTAEKLPTPQEETSLT 556
            +P A +   D S AG  S          P  SQ+ +++ L + S   E     Q     +
Sbjct: 962  SPPAADVLKDFSLAGNFSRKETCCTGQGPNKSQQALADALEEGSQHEEAC---QRHPGAS 1018

Query: 557  LCPDSPQNLKEEGGLDLPSGRKPVAAATIVPRQAKEDLTLPQDSAMTPPLPLQDTDLSSA 616
               D    L      ++ SG    A        A  D  +P   A+ P  P         
Sbjct: 1019 EAADGCSPLWGLSKREMASGNTGEAPPCQPDSVALLD-AVPCLPALAPASP------GVT 1071

Query: 617  PKPVAAATIVSQQAEEGLTLPQDSVMTPPLPLQDTELSSAPKPVAAATLVSQQAEEGLTL 676
            P   A  T    + +EG   P   V  P   ++    S A  P   A+  S   + G   
Sbjct: 1072 PTQDAPETEACDETQEGRQQP---VPAPQQKMECWATSDAESPKLLASFPSAGEQGG--- 1125

Query: 677  PQDSAMTPPLPLQDTDLSSAPKPVAAATLVSQQAEEGLTLPQDSAMTPPLPLQDTDLSSA 736
                         +   +       A     QQA E    P ++ ++  L   +  L+S 
Sbjct: 1126 -------------EAGAAETGGSAGAGDPGKQQAPEK---PGEATLSCGLLQTEHCLTSG 1169

Query: 737  PKPVAAATLVSQQAEEGLTLPQDSAMTPPLPLQDTDLSSAPKPVAAATIVSQQAEEGLTL 796
             +   +A   S QAE  +   QD+       L   +L   P+     + +     + +  
Sbjct: 1170 EEASTSALRESCQAEHPMASCQDAL------LPARELGGIPR-----STMDFSTHQAVPD 1218

Query: 797  PQDSAMTPPLPLQDTDLSSAPKPVAAATIVSQQAEEGLTLPQDSAMTPPLPLQDTDLSSA 856
            P++  ++ P      ++++   P       +Q+  E   +   S+  P  P        +
Sbjct: 1219 PKELLLSGP-----PEVAAPDTPYLHVDSAAQRGAEDSGVKAVSSADPRAP------GES 1267

Query: 857  PKPVAAATPVSQQAEEGLTLPQDSAMTPPLPLQDTDLSSAPKPVAAATPVSQQAE--EGL 914
            P PV    P++ +    L L   S      PL     +    P   A+  S +A   EG 
Sbjct: 1268 PCPVGEP-PLALENAASLKLFAGSLA----PLLQPGAAGGEIPAVQASSGSPKARTTEG- 1321

Query: 915  TLPQDSAMTAPLPLQDTGPTSGPEPLAVATPQTLQAEAGCAPGTEPVATMAQQEVGEALG 974
              P DS     +P  D  P      LA     T + +A  APG    A+  +   G+A G
Sbjct: 1322 --PVDS-----MPCLDRMPL-----LAKGKQATGEEKAATAPGAGAKAS-GEGMAGDAAG 1368

Query: 975  PRPAPEEKNAALPTVPEPAALDQVQQDDPQPAAEAGTPWAAQEDAD----STLGMEALSL 1030
                  E+       P+      V     Q A   G P   +  A       LG  AL+ 
Sbjct: 1369 ETEGSMERMGEPSQDPKQGTSGGVDTSSEQIATLTGFPDFREHIAKIFEKPVLG--ALAT 1426

Query: 1031 PEPASGAGEE-IAEALSRP-GREACLEARAHTGDGAKPDSPQKETLEVENQQEGGLKPLA 1088
            P   +GAG   + + L+RP G E  L+          P  P +  L+VE +Q+       
Sbjct: 1427 PGEKAGAGRSAVGKDLTRPLGPEKLLDGPPGVDVTLLPAPPAR--LQVEKKQQ------- 1477

Query: 1089 QEHGPRSALGGAREVPDAPPAACPEVSQARLLSPA--REERGLSGKSTPE------PTLP 1140
                    L G  E+      A  + +  +LL PA    ER L G    +      PTL 
Sbjct: 1478 --------LAGEAEISHL---ALQDPASDKLLGPAGLTWERNLPGAGVGKEMAGVPPTLR 1526

Query: 1141 SAVATEASLDSCPESSVGAVSSLDRGCPDAPAPTSAPTSQQPEPVLGLGSVE---QPHEV 1197
                 E    + P     A S L+R   +  +   +P + Q  PV    + +     H  
Sbjct: 1527 EDERPEGPGAAWPGLEGQAYSQLERSRQELASGLPSPAATQELPVERAAAFQVAPHSHGE 1586

Query: 1198 PSVLGTPLLQPPENLAKGQPSTPVDRPLGPDPSAPGTLAGAALPPLEPPAPCLCQDPQED 1257
             +V    +    ++    Q ++  D P G D   PG  A   +P   P + C    PQ +
Sbjct: 1587 EAVAQDRIPSGKQH----QETSACDSPHGED--GPGDFAHTGVPGHVPRSTC-APSPQRE 1639

Query: 1258 SV---EDEEPPGSLGL------PPPQAGVQPAAAAVSGTTQPLGTGPRVSLSPHSPLLSP 1308
             +   E    P +L        P   AG+     A+   + P      V+ +P  P    
Sbjct: 1640 VLTVPEANSEPWTLDTLGGERRPGVTAGILEMRNALGNQSTPAPPTGEVADTPLEPGKVA 1699

Query: 1309 KVASMDAKDLALQ----------------------------ILP-PCQVPPPS----GPQ 1335
              A     D+ L                             +LP  CQ P  S    G +
Sbjct: 1700 GAAGEAEGDITLSTAETQACASGDLPEAGTTRTFSVVAGDLVLPGSCQDPACSDKAPGME 1759

Query: 1336 SPAGPQGLSAPEQQEDEDSLEEDSPRALGSGQHSDSHGESSAELDEQDI--LAPQTVQCP 1393
              A   G S    Q+ ++    + P   G G+   S      E  +  +  LAP+ +   
Sbjct: 1760 GTAALHGDSPARPQQAKEQPGPERPIPAGDGKVCVSSPPEPDETHDPKLQHLAPEELHTD 1819

Query: 1394 AQAPAGGSEETIAKAKQSRSEKKARKAMSKLGLRQIQGVTRITIQKSKNILFVIAKPDVF 1453
             ++P  G     +  K     K A + M K+   + +G          + +   A P   
Sbjct: 1820 RESPRPGPSMLPSVPK-----KDAPRVMDKVTSDETRGAEGTESSPVADDIIQPAAPADL 1874

Query: 1454 KSP--ASDTYV--VFGEAKIEDLSQQVHKAAAEKFKVPSEPSALVPESAP 1499
            +SP  A+ +Y   V G+   + ++Q +  AAA     PS    +V  SAP
Sbjct: 1875 ESPTLAASSYHGDVVGQVSTDLIAQSISPAAAHAGLPPSAAEHIVSPSAP 1924



 Score = 43.9 bits (102), Expect = 0.001
 Identities = 156/706 (22%), Positives = 252/706 (35%), Gaps = 99/706 (14%)

Query: 460  QRQELISEVTEEGLALGQESTATVTPHTLQVA-----PGLQVEVATRVTPQAGEEETDST 514
            +R  + + + E   ALG +ST    P T +VA     PG       +V   AGE E D T
Sbjct: 1660 RRPGVTAGILEMRNALGNQSTPA--PPTGEVADTPLEPG-------KVAGAAGEAEGDIT 1710

Query: 515  AGQ-ESAAMAMPQPSQEGISEILG------------QESVTAEKLPTPQEETSLTL-CPD 560
                E+ A A     + G +                Q+   ++K P  +   +L    P 
Sbjct: 1711 LSTAETQACASGDLPEAGTTRTFSVVAGDLVLPGSCQDPACSDKAPGMEGTAALHGDSPA 1770

Query: 561  SPQNLKEEGGLD--LPSGRKPVAAATI----------VPRQAKEDLTLPQDSAMTPPLPL 608
             PQ  KE+ G +  +P+G   V  ++           +   A E+L   ++S    P  L
Sbjct: 1771 RPQQAKEQPGPERPIPAGDGKVCVSSPPEPDETHDPKLQHLAPEELHTDRESPRPGPSML 1830

Query: 609  QDTDLSSAPKPVAAATIVSQQAEEGLTLPQDSVMTPPLPLQDTELS-SAPKPVAAATLVS 667
                   AP+ +   T    +  EG         T   P+ D  +  +AP  + + TL +
Sbjct: 1831 PSVPKKDAPRVMDKVTSDETRGAEG---------TESSPVADDIIQPAAPADLESPTLAA 1881

Query: 668  QQAEEGLTLPQDSAMTPPLPLQDTDLSSAPKPVAAATLVSQQAEEGLTLPQDSAMTPPLP 727
              +  G  + Q S       +      +   P AA  +VS  A  G    +  A TP  P
Sbjct: 1882 S-SYHGDVVGQVSTDLIAQSISPAAAHAGLPPSAAEHIVSPSAPAG---DRVEASTPSCP 1937

Query: 728  LQDTDLSSAPKPVAAATLVSQQAEEGLTLPQDSAMTPPLPLQDTDLSSAPKPVAAATIVS 787
                DLS            S  +EE    P+    T P+          P+ +    + +
Sbjct: 1938 DPAKDLSR-----------SSDSEEAFETPES---TTPVKAPPAPPPPPPEVIPEPEVST 1983

Query: 788  QQAEEGLTLPQDSAMTPPLPLQDTDLSSAPKPVAAATIVSQQAEEGLTLPQDSAMT---P 844
            Q   E      ++   P  P  D+   S  +P + +   S   +E   +           
Sbjct: 1984 QPPPEEPGCGSETVPVPDGPRSDSVEGSPFRPPSHS--FSAVFDEDKPIASSGTYNLDFD 2041

Query: 845  PLPLQDTDLSSAPKPVAAATP---VSQQAEEGLTLP-QDSAMTPPLPLQDTDLSSA---- 896
             + L DT  +  P+   A      V+ + +   ++P   S ++  L LQ +D   A    
Sbjct: 2042 NIELVDTFQTLEPRASDAKNQEGKVNTRRKSTDSVPISKSTLSRSLSLQASDFDGASSSG 2101

Query: 897  -PKPVAAATPV-SQQAEEGLTLPQDSAMTAPLPLQDTGPTSGP-EPLAVATPQTLQAEAG 953
             P+ VA A    S  +    +  + +    P  L+    T  P E   V   Q    E  
Sbjct: 2102 NPEAVALAPDAYSTGSSSASSTLKRTKKPRPPSLKKKQTTKKPTETPPVKETQQEPDEES 2161

Query: 954  CAPGTEPVATMAQQEVGEALGPRPAPEEKNAALPTVPEPAA--LDQVQQDDPQPAAEAG- 1010
              P  E +A+  + E  +  GP PA  E+    P V   AA  LD    +   P A  G 
Sbjct: 2162 LVPSGENLASETKTESAKTEGPSPALLEETPLEPAVGPKAACPLDSESAEGVVPPASGGG 2221

Query: 1011 ----TPWAAQEDADSTLGMEALSLPEPASGAGEEIAEALSRPGREACLEARAHTGDGAKP 1066
                +P   ++    T   EA  +  P+   G+E + A    G    LE   ++ D +  
Sbjct: 2222 RVQNSPPVGRKTLPLTTAPEAGEV-TPSDSGGQEDSPA---KGLSVRLEF-DYSEDKSSW 2276

Query: 1067 DSPQKETLEVENQQEGGLKPLAQEHGPRSALGGAREVPDAPPAACP 1112
            D+ Q+        ++ G KP+A+    R  +    E  D  PA+ P
Sbjct: 2277 DNQQENP---PPTKKIGKKPVAKMPLRRPKMKKTPEKLDNTPASPP 2319



 Score = 42.4 bits (98), Expect = 0.004
 Identities = 225/1104 (20%), Positives = 368/1104 (33%), Gaps = 174/1104 (15%)

Query: 271  PEPPSSESSLSADSSSSWGQEGHFFDLDFLAND--PMIPAALLPFQGSLIFQVEAVEVTP 328
            P P     ++   +S  W        LD L  +  P + A +L  + +L       + TP
Sbjct: 1634 PSPQREVLTVPEANSEPW-------TLDTLGGERRPGVTAGILEMRNAL-----GNQSTP 1681

Query: 329  LSPEEEEEEAVADPDPGGDLAGEGEEDST-SASFLQSLSDLSITE-GMDEAFA-FRDDTS 385
              P  E  +   +P      AGE E D T S +  Q+ +   + E G    F+    D  
Sbjct: 1682 APPTGEVADTPLEPGKVAGAAGEAEGDITLSTAETQACASGDLPEAGTTRTFSVVAGDLV 1741

Query: 386  AASSDSDSASYAEADDERLYSGEPHAQATLLQDSVQKTEE--ESGGGAKGLQAQDGTVSW 443
               S  D A   +A             A L  DS  + ++  E  G  + + A DG V  
Sbjct: 1742 LPGSCQDPACSDKAPG-------MEGTAALHGDSPARPQQAKEQPGPERPIPAGDGKV-- 1792

Query: 444  AVEAAPQTSDRGAYLSQRQELISEVTEEGLALGQESTATVTPHTLQVAPGLQVEVATRVT 503
             V + P+  +           +  +  E L   +ES          + P +  + A RV 
Sbjct: 1793 CVSSPPEPDE------THDPKLQHLAPEELHTDRESPRPGP----SMLPSVPKKDAPRVM 1842

Query: 504  PQAGEEETDSTAGQESAAMA-----------MPQPSQEGIS---EILGQESVTAEKLPTP 549
             +   +ET    G ES+ +A           +  P+    S   +++GQ S         
Sbjct: 1843 DKVTSDETRGAEGTESSPVADDIIQPAAPADLESPTLAASSYHGDVVGQVSTDLIAQSIS 1902

Query: 550  QEETSLTLCPDSPQNLKEEGGLDLPSGRKPVAAATIVPRQAKEDLTLPQDSAMTPPLPLQ 609
                   L P + +++        P+G +  A+    P  AK DL+   DS      P  
Sbjct: 1903 PAAAHAGLPPSAAEHIVSPSA---PAGDRVEASTPSCPDPAK-DLSRSSDSEEAFETPES 1958

Query: 610  DTDLSSAPKP-------VAAATIVSQQAEEGLTLPQDSVMTPPLPLQDTELSSAPKPVAA 662
             T + + P P       +    + +Q   E      ++V  P  P  D+   S  +P + 
Sbjct: 1959 TTPVKAPPAPPPPPPEVIPEPEVSTQPPPEEPGCGSETVPVPDGPRSDSVEGSPFRPPSH 2018

Query: 663  ATLVSQQAEEGLTLPQDSAMT---PPLPLQDTDLSSAPKPVAAAT---LVSQQAEEGLTL 716
            +   S   +E   +            + L DT  +  P+   A      V+ + +   ++
Sbjct: 2019 S--FSAVFDEDKPIASSGTYNLDFDNIELVDTFQTLEPRASDAKNQEGKVNTRRKSTDSV 2076

Query: 717  P-QDSAMTPPLPLQDTDLSSA-----PKPVAAA--TLVSQQAEEGLTLPQDSAMTPPLPL 768
            P   S ++  L LQ +D   A     P+ VA A     +  +    TL +     PP  L
Sbjct: 2077 PISKSTLSRSLSLQASDFDGASSSGNPEAVALAPDAYSTGSSSASSTLKRTKKPRPP-SL 2135

Query: 769  QDTDLSSAPKPVAAATIVSQQAEEGLTLPQ----------DSAMT---PPLPLQDTDLSS 815
            +    +  P          Q+ +E   +P           +SA T    P  L++T L  
Sbjct: 2136 KKKQTTKKPTETPPVKETQQEPDEESLVPSGENLASETKTESAKTEGPSPALLEETPLEP 2195

Query: 816  APKPVAAATIVSQQAEEGLTLPQDSA----MTPPLPLQDTDLSSAPKPVAAATPVSQQAE 871
            A  P AA  + S+ A EG+  P         +PP+  +   L++AP             E
Sbjct: 2196 AVGPKAACPLDSESA-EGVVPPASGGGRVQNSPPVGRKTLPLTTAP-------------E 2241

Query: 872  EGLTLPQDSAMTPPLPLQDTDLS-SAPKPVAAATPVSQQAEEGLTLPQDSAMTAPLPLQD 930
             G   P DS      P +   +          ++  +QQ     T        A +PL+ 
Sbjct: 2242 AGEVTPSDSGGQEDSPAKGLSVRLEFDYSEDKSSWDNQQENPPPTKKIGKKPVAKMPLRR 2301

Query: 931  TGPTSGPEPL--AVATPQTLQAEAGCAPGTEPVATMAQQEVGEALGPRPAPEEKNAALPT 988
                  PE L    A+P    AE    P  +   T    ++ +   P   P    + +  
Sbjct: 2302 PKMKKTPEKLDNTPASPPRSPAEPNDIPIAKGTYTF---DIDKWDDPNFNPFSSTSKMQ- 2357

Query: 989  VPEPAALDQVQQDDPQPAAEAGTPWAAQEDADSTLGMEALSLPEPASG--AGEEIAEALS 1046
               P    Q    DP    E+  P+       S+      S   PAS   A     + L+
Sbjct: 2358 -ESPKLPQQSYNFDPDTCDESVDPFKTSSKTPSSPSKSPASFEIPASAMEANGVDGDGLN 2416

Query: 1047 RPGREACLEARAHT--------------------GDGAKPDSPQKETLEVENQQEGGLKP 1086
            +P ++     +  T                       A P++P   +  V    E  L  
Sbjct: 2417 KPAKKKKTPLKTDTFRVKKSPKRSPLSDPPSQDPTPAATPETPPVISAVVHATDEEKLAV 2476

Query: 1087 LAQEHGPRSA-LGGAREVPDAPPAACPEVSQARLLSPAR----------EERGLSGKSTP 1135
              Q+    +  L   ++    P      V++ +  SP            E     G S P
Sbjct: 2477 TNQKWTCMTVDLEADKQDYPQPSDLSTFVNETKFSSPTEELDYRNSYEIEYMEKIGSSLP 2536

Query: 1136 -EPTLPSAVATEASLDSCPESSVGAVSSLDRGCPDAPAPTSAPTSQQPEPVLGLGSVEQP 1194
             +   P   A     D+  ES    V S      ++P P S  + ++ E ++   +  Q 
Sbjct: 2537 QDDDAPKKQALYLMFDTSQES---PVKSSPVRMSESPTPCSGSSFEETEALVNTAAKNQ- 2592

Query: 1195 HEVPSVLG---TPLLQPPEN--------LAKGQPSTPVD--RPLGPDPSAPGTLAGAALP 1241
            H VP  L       LQ PE         +  G PS  ++   P G   SA   L+  A  
Sbjct: 2593 HPVPRGLAPNQESHLQVPEKSSQKELEAMGLGTPSEAIEITAPEGSFASADALLSRLA-- 2650

Query: 1242 PLEPPAPCLCQDPQEDSVEDEEPP 1265
               P + C   D  E  + ++ PP
Sbjct: 2651 --HPVSLCGALDYLEPDLAEKNPP 2672


>gi|207113162 Treacher Collins-Franceschetti syndrome 1 isoform e
            [Homo sapiens]
          Length = 1451

 Score = 86.3 bits (212), Expect = 2e-16
 Identities = 198/981 (20%), Positives = 339/981 (34%), Gaps = 122/981 (12%)

Query: 510  ETDSTAGQESAAMAMPQPSQEGISEILGQESVTAEKLPTPQEETSLTLCPDSPQNLKEEG 569
            E D+    +   ++ P  + E   E    E+ TA+  P      S  L  D P ++KE+ 
Sbjct: 66   EEDAALQAKKTRVSDPISTSESSEEEEEAEAETAKATPRLASTNSSVLGADLPSSMKEKA 125

Query: 570  GLDLPSGRKPVAAATIVPRQAKEDLTLPQDSAMTPPLPLQDTDLSSAPKPVAAATIVSQQ 629
              +     K       +P  A         S  +P           + +P A  T+VS+ 
Sbjct: 126  KAETEKAGK---TGNSMPHPATGKTVANLLSGKSP---------RKSAEPSANTTLVSET 173

Query: 630  AEEGLTLPQDSVMTPPLPLQDTELSSAPKPVAAATLVSQQAEEGLTLPQDSAMTPPLPLQ 689
             EEG ++P       P  +   +  S+ +  ++++  +    +    P     +     +
Sbjct: 174  EEEG-SVPAFGAAAKPGMVSAGQADSSSEDTSSSSDETDVEGKPSVKPAQVKASSVSTKE 232

Query: 690  DTDLSSAPKPVAAATLVSQQAEEGLTLPQDSAMTPPLPLQDTDLSSAPKPVAAATLVSQQ 749
                 +AP P      V+ Q + G   P   A  P    + ++  S  +  A A   SQ 
Sbjct: 233  SPARKAAPAPGKVGD-VTPQVKGGALPPAKRAKKPEEESESSEEGSESEEEAPAGTRSQV 291

Query: 750  AEEGLTLPQDSAMTPPLPLQDTDLSSAPKPVAAATIVSQQAEEGLTLPQDSAMTPPLPLQ 809
                  L   +A  P         + AP   A A  V+ Q + G   P++ + +      
Sbjct: 292  KASEKILQVRAASAPAKGTPGKGATPAPPGKAGA--VASQTKAGK--PEEDSES-----S 342

Query: 810  DTDLSSAPKPVAAATIVSQQAEEGLTLPQDSAMTPPLPLQDTDLSSAPK----PVAAATP 865
              + S + +   AA  + Q    G T    +A  P         + AP     P  A   
Sbjct: 343  SEESSDSEEETPAAKALLQAKASGKTSQVGAASAPAKESPRKGAAPAPPGKTGPAVAKAQ 402

Query: 866  VSQQAEEGLTLPQDSAMTPPLPLQDTDLSSAPKPVAAATPVSQQAEEGLTLPQDSAMTAP 925
              ++ E+  +  ++S      P Q      AP+  AA+ P  +   +G          AP
Sbjct: 403  AGKREEDSQSSSEESDSEEEAPAQAKPSGKAPQVRAASAPAKESPRKG---------AAP 453

Query: 926  LPLQDTGPT-------------------SGPEPLAVATPQTLQAEA-GCAPGTEPVATMA 965
             P + TGP                    S  +  A+A     Q +  G +P  +P +TM 
Sbjct: 454  APPRKTGPAAAQVQVGKQEEDSRSSSEESDSDREALAAMNAAQVKPLGKSPQVKPASTMG 513

Query: 966  QQEVGEALGPRPAPEEKNAALPT--VPEPAALDQVQQDDPQPAAEAGTPWAAQEDADSTL 1023
               +G+  GP P P +   A P+  V +     +   ++   +++   P A     + +L
Sbjct: 514  MGPLGKGAGPVP-PGKVGPATPSAQVGKWEEDSESSSEESSDSSDGEVPTAVAPAQEKSL 572

Query: 1024 G--MEALSLPEPASGAGEEIAEALSRPGREACL---EARAHTGDGAKPDSPQKETLEVEN 1078
            G  ++A     PA G  ++      +   E  +   E+   + D A  DS +        
Sbjct: 573  GNILQAKPTSSPAKGPPQKAGPVAVQVKAEKPMDNSESSEESSDSA--DSEEAPAAMTAA 630

Query: 1079 QQEGGLKPLAQEHGPR--SALGGAREVPDAPPAACPEVSQARLLSPAREERGLSGKSTPE 1136
            Q +  LK    +  P+  +    A+  P       P  +     SPA     ++G  T  
Sbjct: 631  QAKPALKIPQTKACPKKTNTTASAKVAPVRVGTQAPRKA-GTATSPAGSSPAVAG-GTQR 688

Query: 1137 PTLPSAVATEASLDSCPESS-----VGAVSSLDRGCP--DAPAPTSAPTSQQPEPVL--- 1186
            P   S+ + E+  DS  E +     VG   S+ +G     A  P      Q   PVL   
Sbjct: 689  PAEDSSSSEES--DSEEEKTGLAVTVGQAKSVGKGLQVKAASVPVKGSLGQGTAPVLPGK 746

Query: 1187 --------------GLGSVEQPHEVPSVLGTPL---LQPPENLAKGQPSTPVDRPLGPDP 1229
                             S E+  +      +P        +  AK  P+           
Sbjct: 747  TGPTVTQVKAEKQEDSESSEEESDSEEAAASPAQVKTSVKKTQAKANPAAARAPSAKGTI 806

Query: 1230 SAPGTLAGAALPP-------LEPPAPCLCQDPQEDSVEDEEPPGSLGLPPPQAGVQPAAA 1282
            SAPG +  AA          ++PP     ++PQ  +V    P     +P     V  AA 
Sbjct: 807  SAPGKVVTAAAQAKQRSPSKVKPPV----RNPQNSTVLARGPAS---VPSVGKAVATAAQ 859

Query: 1283 AVSGTTQPLGTGPRVSLSPH-SPLLSPKVASMDAKDLALQILPPCQVPPPSGPQSPAGPQ 1341
            A +G  +  G+    S S   +  L+    S     +   + P  + P      +P G  
Sbjct: 860  AQTGPEEDSGSSEEESDSEEEAETLAQVKPSGKTHQIRAALAPAKESPRKGAAPTPPGKT 919

Query: 1342 GLSAPEQQEDEDSLEEDSPRALGSGQHSDSHGESSAELDEQDILAPQTVQCPAQAPAGGS 1401
            G SA +  + +DS          S + SDS GE+ A +    ++ P  +         G 
Sbjct: 920  GPSAAQAGKQDDSGS--------SSEESDSDGEAPAAVTSAQVIKPPLIFVDPNRSPAGP 971

Query: 1402 EETIAKAKQSRSEKKARKAMS 1422
              T A+A+ + + +KAR + S
Sbjct: 972  AATPAQAQAASTPRKARASES 992



 Score = 76.6 bits (187), Expect = 2e-13
 Identities = 248/1208 (20%), Positives = 411/1208 (34%), Gaps = 171/1208 (14%)

Query: 348  LAGEGEEDSTSASFLQSLSDLSITEGMDEAF---AFRDDTSAASSDSDSASYAEADDERL 404
            L+G+    S   S   +L   +  EG   AF   A     SA  +DS S   + + DE  
Sbjct: 152  LSGKSPRKSAEPSANTTLVSETEEEGSVPAFGAAAKPGMVSAGQADSSSEDTSSSSDETD 211

Query: 405  YSGEPHAQATLLQDSVQKTEEESGGGAKGLQAQDGTVSWAVEAAPQTSDRGAYLSQRQEL 464
              G+P  +   ++ S   T+E     A     + G V+  V+       + A   ++ E 
Sbjct: 212  VEGKPSVKPAQVKASSVSTKESPARKAAPAPGKVGDVTPQVKGGALPPAKRA---KKPEE 268

Query: 465  ISEVTEEGLALGQESTATVTPHTLQVAPGLQVEVATRVTPQAGEEETDSTAGQESAAMAM 524
             SE +EEG    +E+ A            LQV  A+   P  G     +T      A A+
Sbjct: 269  ESESSEEGSESEEEAPAGTRSQVKASEKILQVRAAS--APAKGTPGKGATPAPPGKAGAV 326

Query: 525  PQPSQEGISEILGQESVTAEKLPTPQEETSLTLCPDSPQNLKEEGGLDLPSGRKPVAAAT 584
               ++ G  E   + S  +E+    +EET     P +   L+ +      SG+     A 
Sbjct: 327  ASQTKAGKPEEDSESS--SEESSDSEEET-----PAAKALLQAKA-----SGKTSQVGAA 374

Query: 585  IVPRQAKEDLTLPQDSAMTPPLPLQDTDLSSAPKPVAAATIVSQQAEEGLTLPQDSVMTP 644
              P  AKE    P+  A   P             P  A     ++ E+  +  ++S    
Sbjct: 375  SAP--AKES---PRKGAAPAP--------PGKTGPAVAKAQAGKREEDSQSSSEESDSEE 421

Query: 645  PLPLQDTELSSAPKPVAAATLVSQQAEEGLTLPQDSAMTPPLPLQDTDLSSAPKPVAAAT 704
              P Q      AP+  AA+    +   +G           P P + T       P AA  
Sbjct: 422  EAPAQAKPSGKAPQVRAASAPAKESPRKG---------AAPAPPRKTG------PAAAQV 466

Query: 705  LVSQQAEEGLTLPQDS-----AMTPPLPLQDTDLSSAPKPVAAATLVSQQAEEGLTLPQD 759
             V +Q E+  +  ++S     A+      Q   L  +P+   A+T+      +G      
Sbjct: 467  QVGKQEEDSRSSSEESDSDREALAAMNAAQVKPLGKSPQVKPASTMGMGPLGKGAGPVPP 526

Query: 760  SAMTPPLPL-------QDTDLS------SAPKPVAAATIVSQQAEEGLTLPQDSAMTPPL 806
              + P  P        +D++ S      S+   V  A   +Q+   G  L      +P  
Sbjct: 527  GKVGPATPSAQVGKWEEDSESSSEESSDSSDGEVPTAVAPAQEKSLGNILQAKPTSSP-- 584

Query: 807  PLQDTDLSSAPKPVAAATIVSQQAEEGLTLPQDSAMTPPLPLQDTDLSSAPKPVAAATPV 866
                   +  P   A    V  +AE+    P D++ +        D   AP  + AA   
Sbjct: 585  -------AKGPPQKAGPVAVQVKAEK----PMDNSESSEESSDSADSEEAPAAMTAA--- 630

Query: 867  SQQAEEGLTLPQDSAMTPPLPLQDTDLSSAPKPVAAATPVSQQAEEGLTLPQDSAMTA-- 924
              QA+  L +PQ  A        +T  S+   PV   T   ++A    +    S   A  
Sbjct: 631  --QAKPALKIPQTKACPKK---TNTTASAKVAPVRVGTQAPRKAGTATSPAGSSPAVAGG 685

Query: 925  -PLPLQDTGPTSGPEPLAVATPQTLQAEAGCAPGTEPVATMAQQEVGEALGPRPAPEEKN 983
               P +D+  +   +     T   +      + G       A   V  +LG   AP    
Sbjct: 686  TQRPAEDSSSSEESDSEEEKTGLAVTVGQAKSVGKGLQVKAASVPVKGSLGQGTAPVLPG 745

Query: 984  AALPTVPEPAALDQVQQDDPQPAAEAGTPWAAQEDAD-STLGMEALSLPEPASGAGEEIA 1042
               PTV +  A  + Q+D      E+ +  AA   A   T   +  +   PA+       
Sbjct: 746  KTGPTVTQVKA--EKQEDSESSEEESDSEEAAASPAQVKTSVKKTQAKANPAAARAPSAK 803

Query: 1043 EALSRPGR--EACLEARAHTGDGAKPD--SPQKETL------EVENQQEGGLKPLAQEHG 1092
              +S PG+   A  +A+  +    KP   +PQ  T+       V +  +        + G
Sbjct: 804  GTISAPGKVVTAAAQAKQRSPSKVKPPVRNPQNSTVLARGPASVPSVGKAVATAAQAQTG 863

Query: 1093 PRSALGGAREVPDAPPAA--------CPEVSQAR-LLSPAREE-RGLSGKSTPEPTLPSA 1142
            P    G + E  D+   A          +  Q R  L+PA+E  R  +  + P  T PSA
Sbjct: 864  PEEDSGSSEEESDSEEEAETLAQVKPSGKTHQIRAALAPAKESPRKGAAPTPPGKTGPSA 923

Query: 1143 VATEASLDSCPESSVGAVSSLDRGCPDAPAPTSAPTSQQPEPVLGLGSVEQPHEVPSVLG 1202
                   DS         SS +    D  AP +  ++Q  +P L       P+  P+   
Sbjct: 924  AQAGKQDDS--------GSSSEESDSDGEAPAAVTSAQVIKPPL---IFVDPNRSPA--- 969

Query: 1203 TPLLQPPENLAKGQPSTPVDRPLGPDPSAPGTLAGAALPPLEPPAPCLCQDPQEDSVEDE 1262
                 P    A+ Q ++   +    + +A  + + +    + P   CL    + + V   
Sbjct: 970  ----GPAATPAQAQAASTPRKARASESTARSSSSESEDEDVIPATQCLTPGIRTNVVTMP 1025

Query: 1263 EPPGSLGLPPPQAGVQPA--AAAVSGTTQPLGTGPRVSLSPHS-PLLSPKVASMDAKDLA 1319
                 +      AG   +  ++ +S   +  G   +V  +  + P  SP+  S+ AK   
Sbjct: 1026 TAHPRIAPKASMAGASSSKESSRISDGKKQEGPATQVDSAVGTLPATSPQSTSVQAKG-- 1083

Query: 1320 LQILPPCQVPPPSGPQSPAGPQGLSAPEQQEDEDSLEEDSPRALGSGQHSDSHGESSAEL 1379
                          P+ P   Q   APE  +D +   + S     SG   D  G   A+ 
Sbjct: 1084 --------TNKLRKPKLPEVQQATKAPESSDDSEDSSDSS-----SGSEEDGEGPQGAKS 1130

Query: 1380 DEQDILAPQTVQCPAQAPAGGSEETIAK--AKQSRSEKKARKAMSKLGLRQIQGVTRITI 1437
                +            P     ET+ +  A +S  +     + S L      G+T    
Sbjct: 1131 AHTLV-----------GPTPSRTETLVEETAAESSEDDVVAPSQSLLSGYMTPGLTPANS 1179

Query: 1438 QKSKNILFVIAKPDVFKSPASDTYVVF---GEAKIEDLSQQVHKAAAEKFKVPSEPSALV 1494
            Q SK      A P +  SP+  + +      + K E   QQ     + K       S   
Sbjct: 1180 QASK------ATPKLDSSPSVSSTLAAKDDPDGKQEAKPQQAAGMLSPKTGGKEAASGTT 1233

Query: 1495 PESAPRPR 1502
            P+ + +P+
Sbjct: 1234 PQKSRKPK 1241



 Score = 64.7 bits (156), Expect = 7e-10
 Identities = 155/780 (19%), Positives = 273/780 (35%), Gaps = 87/780 (11%)

Query: 809  QDTDLSSAPKPVAAATIVSQQAEEGLTLPQDSAM-TPPLPLQDTDLSSAPKPVAAATPVS 867
            +D  L +    V+     S+ +EE      ++A  TP L   ++ +  A  P +      
Sbjct: 67   EDAALQAKKTRVSDPISTSESSEEEEEAEAETAKATPRLASTNSSVLGADLPSSMKEKAK 126

Query: 868  QQAEE----GLTLPQDSA-MTPPLPLQDTDLSSAPKPVAAATPVSQQAEEGLTLPQDSAM 922
             + E+    G ++P  +   T    L       + +P A  T VS+  EEG ++P   A 
Sbjct: 127  AETEKAGKTGNSMPHPATGKTVANLLSGKSPRKSAEPSANTTLVSETEEEG-SVPAFGAA 185

Query: 923  TAPLPLQDTGPTSGPEPLAVATPQT-LQAEAGCAPGTEPVATMAQQEV-GEALGPRPA-- 978
              P  +      S  E  + ++ +T ++ +    P     ++++ +E       P P   
Sbjct: 186  AKPGMVSAGQADSSSEDTSSSSDETDVEGKPSVKPAQVKASSVSTKESPARKAAPAPGKV 245

Query: 979  ----PEEKNAALPTV-----PEPAALDQVQQDDPQPAAEAGTPWAAQEDADSTLGMEALS 1029
                P+ K  ALP       PE  +    +  + +  A AGT  +  + ++  L + A S
Sbjct: 246  GDVTPQVKGGALPPAKRAKKPEEESESSEEGSESEEEAPAGTR-SQVKASEKILQVRAAS 304

Query: 1030 LPEPAS-GAGEEIAEALSRPGREACLEARAHTGDGAKPDSPQKETLEVENQQEGGLKPL- 1087
             P   + G G   A     PG+   + ++   G   +      E      ++    K L 
Sbjct: 305  APAKGTPGKGATPAP----PGKAGAVASQTKAGKPEEDSESSSEESSDSEEETPAAKALL 360

Query: 1088 -AQEHGPRSALGGA----REVP-----DAPPAAC-PEVSQARLLSPAREERGLSGKSTPE 1136
             A+  G  S +G A    +E P      APP    P V++A+      + +  S +S  E
Sbjct: 361  QAKASGKTSQVGAASAPAKESPRKGAAPAPPGKTGPAVAKAQAGKREEDSQSSSEESDSE 420

Query: 1137 PTLPSAVATEASLDSCPESSVGAVSSLDRGCPDAPAPTSAPTSQQPEPVLGLGSVEQPHE 1196
               P+             +S  A  S  +G   AP   + P + Q +    +G  E+   
Sbjct: 421  EEAPAQAKPSGKAPQVRAASAPAKESPRKGAAPAPPRKTGPAAAQVQ----VGKQEEDSR 476

Query: 1197 VPSVLGTPLLQPPENLAKGQPSTPVDRPLGPDPSAPGTLAGAALPPLEPPAPCLCQDPQE 1256
              S          +  A    +    +PLG  P                PA  +   P  
Sbjct: 477  SSSEESDS-----DREALAAMNAAQVKPLGKSPQVK-------------PASTMGMGPLG 518

Query: 1257 DSVEDEEPPGSLGLPPPQAGVQPAAAAVSGTTQPLGTGPRVSLSPHSPLLSPKVASMDAK 1316
                     G+  +PP + G    +A V    +   +    S       +   VA    K
Sbjct: 519  K--------GAGPVPPGKVGPATPSAQVGKWEEDSESSSEESSDSSDGEVPTAVAPAQEK 570

Query: 1317 DLALQILPPCQVPPPSGPQSPAGPQGLSAPEQQEDEDSLEEDSPRALGSGQHSDSHGESS 1376
             L   +       P  GP   AGP  +    ++  ++S  E S  +  S    ++    +
Sbjct: 571  SLGNILQAKPTSSPAKGPPQKAGPVAVQVKAEKPMDNS--ESSEESSDSADSEEAPAAMT 628

Query: 1377 AELDEQDILAPQTVQCPAQAPAGGSEETIAKAKQSRSEKKARKAMSKLGLR-QIQGVTRI 1435
            A   +  +  PQT  CP +     S +       +++ +KA  A S  G    + G T+ 
Sbjct: 629  AAQAKPALKIPQTKACPKKTNTTASAKVAPVRVGTQAPRKAGTATSPAGSSPAVAGGTQR 688

Query: 1436 TIQKSKNILFVIAKPDVFKSPASDTYVVFGEAKIEDLSQQVHKAAAEKFK---------- 1485
              + S +     ++    +   +   V  G+AK      QV KAA+   K          
Sbjct: 689  PAEDSSS-----SEESDSEEEKTGLAVTVGQAKSVGKGLQV-KAASVPVKGSLGQGTAPV 742

Query: 1486 VPSEPSALVPESAPRPRVRLECKEEEEEEEEEVDEAGLELRDIELVMAQANVSRAKAVRA 1545
            +P +    V +     +   E  EEE + EE           ++   A+AN + A+A  A
Sbjct: 743  LPGKTGPTVTQVKAEKQEDSESSEEESDSEEAAASPAQVKTSVKKTQAKANPAAARAPSA 802


>gi|207113160 Treacher Collins-Franceschetti syndrome 1 isoform d
            [Homo sapiens]
          Length = 1488

 Score = 86.3 bits (212), Expect = 2e-16
 Identities = 198/981 (20%), Positives = 339/981 (34%), Gaps = 122/981 (12%)

Query: 510  ETDSTAGQESAAMAMPQPSQEGISEILGQESVTAEKLPTPQEETSLTLCPDSPQNLKEEG 569
            E D+    +   ++ P  + E   E    E+ TA+  P      S  L  D P ++KE+ 
Sbjct: 66   EEDAALQAKKTRVSDPISTSESSEEEEEAEAETAKATPRLASTNSSVLGADLPSSMKEKA 125

Query: 570  GLDLPSGRKPVAAATIVPRQAKEDLTLPQDSAMTPPLPLQDTDLSSAPKPVAAATIVSQQ 629
              +     K       +P  A         S  +P           + +P A  T+VS+ 
Sbjct: 126  KAETEKAGK---TGNSMPHPATGKTVANLLSGKSP---------RKSAEPSANTTLVSET 173

Query: 630  AEEGLTLPQDSVMTPPLPLQDTELSSAPKPVAAATLVSQQAEEGLTLPQDSAMTPPLPLQ 689
             EEG ++P       P  +   +  S+ +  ++++  +    +    P     +     +
Sbjct: 174  EEEG-SVPAFGAAAKPGMVSAGQADSSSEDTSSSSDETDVEGKPSVKPAQVKASSVSTKE 232

Query: 690  DTDLSSAPKPVAAATLVSQQAEEGLTLPQDSAMTPPLPLQDTDLSSAPKPVAAATLVSQQ 749
                 +AP P      V+ Q + G   P   A  P    + ++  S  +  A A   SQ 
Sbjct: 233  SPARKAAPAPGKVGD-VTPQVKGGALPPAKRAKKPEEESESSEEGSESEEEAPAGTRSQV 291

Query: 750  AEEGLTLPQDSAMTPPLPLQDTDLSSAPKPVAAATIVSQQAEEGLTLPQDSAMTPPLPLQ 809
                  L   +A  P         + AP   A A  V+ Q + G   P++ + +      
Sbjct: 292  KASEKILQVRAASAPAKGTPGKGATPAPPGKAGA--VASQTKAGK--PEEDSES-----S 342

Query: 810  DTDLSSAPKPVAAATIVSQQAEEGLTLPQDSAMTPPLPLQDTDLSSAPK----PVAAATP 865
              + S + +   AA  + Q    G T    +A  P         + AP     P  A   
Sbjct: 343  SEESSDSEEETPAAKALLQAKASGKTSQVGAASAPAKESPRKGAAPAPPGKTGPAVAKAQ 402

Query: 866  VSQQAEEGLTLPQDSAMTPPLPLQDTDLSSAPKPVAAATPVSQQAEEGLTLPQDSAMTAP 925
              ++ E+  +  ++S      P Q      AP+  AA+ P  +   +G          AP
Sbjct: 403  AGKREEDSQSSSEESDSEEEAPAQAKPSGKAPQVRAASAPAKESPRKG---------AAP 453

Query: 926  LPLQDTGPT-------------------SGPEPLAVATPQTLQAEA-GCAPGTEPVATMA 965
             P + TGP                    S  +  A+A     Q +  G +P  +P +TM 
Sbjct: 454  APPRKTGPAAAQVQVGKQEEDSRSSSEESDSDREALAAMNAAQVKPLGKSPQVKPASTMG 513

Query: 966  QQEVGEALGPRPAPEEKNAALPT--VPEPAALDQVQQDDPQPAAEAGTPWAAQEDADSTL 1023
               +G+  GP P P +   A P+  V +     +   ++   +++   P A     + +L
Sbjct: 514  MGPLGKGAGPVP-PGKVGPATPSAQVGKWEEDSESSSEESSDSSDGEVPTAVAPAQEKSL 572

Query: 1024 G--MEALSLPEPASGAGEEIAEALSRPGREACL---EARAHTGDGAKPDSPQKETLEVEN 1078
            G  ++A     PA G  ++      +   E  +   E+   + D A  DS +        
Sbjct: 573  GNILQAKPTSSPAKGPPQKAGPVAVQVKAEKPMDNSESSEESSDSA--DSEEAPAAMTAA 630

Query: 1079 QQEGGLKPLAQEHGPR--SALGGAREVPDAPPAACPEVSQARLLSPAREERGLSGKSTPE 1136
            Q +  LK    +  P+  +    A+  P       P  +     SPA     ++G  T  
Sbjct: 631  QAKPALKIPQTKACPKKTNTTASAKVAPVRVGTQAPRKA-GTATSPAGSSPAVAG-GTQR 688

Query: 1137 PTLPSAVATEASLDSCPESS-----VGAVSSLDRGCP--DAPAPTSAPTSQQPEPVL--- 1186
            P   S+ + E+  DS  E +     VG   S+ +G     A  P      Q   PVL   
Sbjct: 689  PAEDSSSSEES--DSEEEKTGLAVTVGQAKSVGKGLQVKAASVPVKGSLGQGTAPVLPGK 746

Query: 1187 --------------GLGSVEQPHEVPSVLGTPL---LQPPENLAKGQPSTPVDRPLGPDP 1229
                             S E+  +      +P        +  AK  P+           
Sbjct: 747  TGPTVTQVKAEKQEDSESSEEESDSEEAAASPAQVKTSVKKTQAKANPAAARAPSAKGTI 806

Query: 1230 SAPGTLAGAALPP-------LEPPAPCLCQDPQEDSVEDEEPPGSLGLPPPQAGVQPAAA 1282
            SAPG +  AA          ++PP     ++PQ  +V    P     +P     V  AA 
Sbjct: 807  SAPGKVVTAAAQAKQRSPSKVKPPV----RNPQNSTVLARGPAS---VPSVGKAVATAAQ 859

Query: 1283 AVSGTTQPLGTGPRVSLSPH-SPLLSPKVASMDAKDLALQILPPCQVPPPSGPQSPAGPQ 1341
            A +G  +  G+    S S   +  L+    S     +   + P  + P      +P G  
Sbjct: 860  AQTGPEEDSGSSEEESDSEEEAETLAQVKPSGKTHQIRAALAPAKESPRKGAAPTPPGKT 919

Query: 1342 GLSAPEQQEDEDSLEEDSPRALGSGQHSDSHGESSAELDEQDILAPQTVQCPAQAPAGGS 1401
            G SA +  + +DS          S + SDS GE+ A +    ++ P  +         G 
Sbjct: 920  GPSAAQAGKQDDSGS--------SSEESDSDGEAPAAVTSAQVIKPPLIFVDPNRSPAGP 971

Query: 1402 EETIAKAKQSRSEKKARKAMS 1422
              T A+A+ + + +KAR + S
Sbjct: 972  AATPAQAQAASTPRKARASES 992



 Score = 84.3 bits (207), Expect = 8e-16
 Identities = 268/1253 (21%), Positives = 418/1253 (33%), Gaps = 224/1253 (17%)

Query: 348  LAGEGEEDSTSASFLQSLSDLSITEGMDEAF---AFRDDTSAASSDSDSASYAEADDERL 404
            L+G+    S   S   +L   +  EG   AF   A     SA  +DS S   + + DE  
Sbjct: 152  LSGKSPRKSAEPSANTTLVSETEEEGSVPAFGAAAKPGMVSAGQADSSSEDTSSSSDETD 211

Query: 405  YSGEPHAQATLLQDSVQKTEEESGGGAKGLQAQDGTVSWAVEAAPQTSDRGAYLSQRQEL 464
              G+P  +   ++ S   T+E     A     + G V+  V+       + A   + +  
Sbjct: 212  VEGKPSVKPAQVKASSVSTKESPARKAAPAPGKVGDVTPQVKGGALPPAKRAKKPEEESE 271

Query: 465  ISE---VTEEGLALGQESTATVTPHTLQV------APGLQVEVATRVTP----------Q 505
             SE    +EE    G  S    +   LQV      A G   + AT   P          +
Sbjct: 272  SSEEGSESEEEAPAGTRSQVKASEKILQVRAASAPAKGTPGKGATPAPPGKAGAVASQTK 331

Query: 506  AGEEETDSTAGQESA---------------AMAMPQPSQEGISEILGQESVTAEKLPTPQ 550
            AG+ E DS +  E +               A A  + SQ G +    +ES      P P 
Sbjct: 332  AGKPEEDSESSSEESSDSEEETPAAKALLQAKASGKTSQVGAASAPAKESPRKGAAPAPP 391

Query: 551  EETSLTLCPDSPQNLKEEGGLDLPSGRKPVAAATIVPRQAKEDLTLPQDSAMTPPLPLQD 610
             +T   +        +E    D  S  +   +    P QAK     PQ  A + P   + 
Sbjct: 392  GKTGPAVAKAQAGKREE----DSQSSSEESDSEEEAPAQAKPSGKAPQVRAASAPAK-ES 446

Query: 611  TDLSSAPK------PVAAATIVSQQAEEGLTLPQDS-----VMTPPLPLQDTELSSAPKP 659
                +AP       P AA   V +Q E+  +  ++S      +      Q   L  +P+ 
Sbjct: 447  PRKGAAPAPPRKTGPAAAQVQVGKQEEDSRSSSEESDSDREALAAMNAAQVKPLGKSPQV 506

Query: 660  VAAATLVSQQAEEGLTLPQDSAMTPPLPL-------QDTDLS------SAPKPVAAATLV 706
              A+T+      +G        + P  P        +D++ S      S+   V  A   
Sbjct: 507  KPASTMGMGPLGKGAGPVPPGKVGPATPSAQVGKWEEDSESSSEESSDSSDGEVPTAVAP 566

Query: 707  SQQAEEGLTLPQDSAMTPPLPLQDTDLSSAPKPVAAATLVSQQAEEGLTLPQDSAMTPPL 766
            +Q+   G  L      +P         +  P   A    V  +AE+    P D++ +   
Sbjct: 567  AQEKSLGNILQAKPTSSP---------AKGPPQKAGPVAVQVKAEK----PMDNSESSEE 613

Query: 767  PLQDTDLSSAPKPVAAATIVSQQAEEGLTLPQDSAMTPPLPLQDTDLSSAPKPVAAATIV 826
                 D   AP  + AA     QA+  L +PQ    T   P +    +SA   VA   + 
Sbjct: 614  SSDSADSEEAPAAMTAA-----QAKPALKIPQ----TKACPKKTNTTASA--KVAPVRVG 662

Query: 827  SQQAEEGLTLPQDSAMTPPL------PLQDTDLS----SAPKPVAAATPVSQQAEEGLTL 876
            +Q   +  T    +  +P +      P +D+  S    S  +    A  V Q    G  L
Sbjct: 663  TQAPRKAGTATSPAGSSPAVAGGTQRPAEDSSSSEESDSEEEKTGLAVTVGQAKSVGKGL 722

Query: 877  PQDSAMTPPLPL--QDTDLSSAPKPVAAATPV---SQQAEEGLTLPQDSAMTAPLPLQDT 931
               +A  P      Q T      K     T V    Q+  E      DS   A  P Q  
Sbjct: 723  QVKAASVPVKGSLGQGTAPVLPGKTGPTVTQVKAEKQEDSESSEEESDSEEAAASPAQ-- 780

Query: 932  GPTSGPEPLAVATPQTLQAEAG----CAPGTEPVATMAQQEVGEALGPRPAPEEKN---- 983
              TS  +  A A P   +A +      APG    A    ++   +    P    +N    
Sbjct: 781  VKTSVKKTQAKANPAAARAPSAKGTISAPGKVVTAAAQAKQRSPSKVKPPVRNPQNSTVL 840

Query: 984  ----AALPTVPEPAALDQVQQDDPQPAAEAGTPWAAQEDADSTLGMEALSLPEPASGAGE 1039
                A++P+V +  A     Q  P+   ++G   +++E++DS    E L+  +P SG   
Sbjct: 841  ARGPASVPSVGKAVATAAQAQTGPE--EDSG---SSEEESDSEEEAETLAQVKP-SGKTH 894

Query: 1040 EIAEALSRPGREACLEARAHTGDGAKPDSPQKETLEVENQQEGGLKPLAQEHGPRSALGG 1099
            +I  AL+ P +E+          GA P  P            G   P A + G +   G 
Sbjct: 895  QIRAALA-PAKES-------PRKGAAPTPP------------GKTGPSAAQAGKQDDSGS 934

Query: 1100 AREVPDAPPAACPEVSQARLLSPAREERGLSGKSTPEPTLPSAVATEASLDSCPESSVGA 1159
            + E  D+   A   V+ A+++ P      +       P  P+A   +A   S P  +  +
Sbjct: 935  SSEESDSDGEAPAAVTSAQVIKPPL----IFVDPNRSPAGPAATPAQAQAASTPRKARAS 990

Query: 1160 VSSLDRGCPDAPAPTSAPTSQQPEPVLGLGSVEQPHEVPSVLGTPLLQPPENLAKGQPST 1219
             S+      ++      P +Q   P +    V  P         P + P  ++A    S 
Sbjct: 991  ESTARSSSSESEDEDVIPATQCLTPGIRTNVVTMP------TAHPRIAPKASMAGASSSK 1044

Query: 1220 PVDR-PLGPDPSAPGTLAG----AALPPLEPPAPCLCQDPQEDSVEDEEPPGSLGLPPPQ 1274
               R   G     P T       A+LP  +     L Q   E               PP 
Sbjct: 1045 ESSRISDGKKQEGPATQVSKKNPASLPLTQAALKVLAQKASE-------------AQPPV 1091

Query: 1275 AGVQPAAAAVSGTTQPLGTGPRVSLSPHSPLLSPKVASMDAKDLALQILPPCQVPPPSGP 1334
            A  QP+    SG    +GT          P  SP+  S+ AK                 P
Sbjct: 1092 ARTQPS----SGVDSAVGT---------LPATSPQSTSVQAKG----------TNKLRKP 1128

Query: 1335 QSPAGPQGLSAPEQQEDEDSLEEDSPRALGSGQHSDSHGESSAELDEQDILAPQTVQCPA 1394
            + P   Q   APE  +D +   + S     SG   D  G   A+                
Sbjct: 1129 KLPEVQQATKAPESSDDSEDSSDSS-----SGSEEDGEGPQGAK------------SAHT 1171

Query: 1395 QAPAGGSEETIAK--AKQSRSEKKARKAMSKLGLRQIQGVTRITIQKSKNILFVIAKPDV 1452
              P     ET+ +  A +S  +     + S L      G+T    Q SK      A P +
Sbjct: 1172 LGPTPSRTETLVEETAAESSEDDVVAPSQSLLSGYMTPGLTPANSQASK------ATPKL 1225

Query: 1453 FKSPASDTYVVF---GEAKIEDLSQQVHKAAAEKFKVPSEPSALVPESAPRPR 1502
              SP+  + +      + K E   QQ     + K       S   P+ + +P+
Sbjct: 1226 DSSPSVSSTLAAKDDPDGKQEAKPQQAAGMLSPKTGGKEAASGTTPQKSRKPK 1278



 Score = 64.7 bits (156), Expect = 7e-10
 Identities = 155/780 (19%), Positives = 273/780 (35%), Gaps = 87/780 (11%)

Query: 809  QDTDLSSAPKPVAAATIVSQQAEEGLTLPQDSAM-TPPLPLQDTDLSSAPKPVAAATPVS 867
            +D  L +    V+     S+ +EE      ++A  TP L   ++ +  A  P +      
Sbjct: 67   EDAALQAKKTRVSDPISTSESSEEEEEAEAETAKATPRLASTNSSVLGADLPSSMKEKAK 126

Query: 868  QQAEE----GLTLPQDSA-MTPPLPLQDTDLSSAPKPVAAATPVSQQAEEGLTLPQDSAM 922
             + E+    G ++P  +   T    L       + +P A  T VS+  EEG ++P   A 
Sbjct: 127  AETEKAGKTGNSMPHPATGKTVANLLSGKSPRKSAEPSANTTLVSETEEEG-SVPAFGAA 185

Query: 923  TAPLPLQDTGPTSGPEPLAVATPQT-LQAEAGCAPGTEPVATMAQQEV-GEALGPRPA-- 978
              P  +      S  E  + ++ +T ++ +    P     ++++ +E       P P   
Sbjct: 186  AKPGMVSAGQADSSSEDTSSSSDETDVEGKPSVKPAQVKASSVSTKESPARKAAPAPGKV 245

Query: 979  ----PEEKNAALPTV-----PEPAALDQVQQDDPQPAAEAGTPWAAQEDADSTLGMEALS 1029
                P+ K  ALP       PE  +    +  + +  A AGT  +  + ++  L + A S
Sbjct: 246  GDVTPQVKGGALPPAKRAKKPEEESESSEEGSESEEEAPAGTR-SQVKASEKILQVRAAS 304

Query: 1030 LPEPAS-GAGEEIAEALSRPGREACLEARAHTGDGAKPDSPQKETLEVENQQEGGLKPL- 1087
             P   + G G   A     PG+   + ++   G   +      E      ++    K L 
Sbjct: 305  APAKGTPGKGATPAP----PGKAGAVASQTKAGKPEEDSESSSEESSDSEEETPAAKALL 360

Query: 1088 -AQEHGPRSALGGA----REVP-----DAPPAAC-PEVSQARLLSPAREERGLSGKSTPE 1136
             A+  G  S +G A    +E P      APP    P V++A+      + +  S +S  E
Sbjct: 361  QAKASGKTSQVGAASAPAKESPRKGAAPAPPGKTGPAVAKAQAGKREEDSQSSSEESDSE 420

Query: 1137 PTLPSAVATEASLDSCPESSVGAVSSLDRGCPDAPAPTSAPTSQQPEPVLGLGSVEQPHE 1196
               P+             +S  A  S  +G   AP   + P + Q +    +G  E+   
Sbjct: 421  EEAPAQAKPSGKAPQVRAASAPAKESPRKGAAPAPPRKTGPAAAQVQ----VGKQEEDSR 476

Query: 1197 VPSVLGTPLLQPPENLAKGQPSTPVDRPLGPDPSAPGTLAGAALPPLEPPAPCLCQDPQE 1256
              S          +  A    +    +PLG  P                PA  +   P  
Sbjct: 477  SSSEESDS-----DREALAAMNAAQVKPLGKSPQVK-------------PASTMGMGPLG 518

Query: 1257 DSVEDEEPPGSLGLPPPQAGVQPAAAAVSGTTQPLGTGPRVSLSPHSPLLSPKVASMDAK 1316
                     G+  +PP + G    +A V    +   +    S       +   VA    K
Sbjct: 519  K--------GAGPVPPGKVGPATPSAQVGKWEEDSESSSEESSDSSDGEVPTAVAPAQEK 570

Query: 1317 DLALQILPPCQVPPPSGPQSPAGPQGLSAPEQQEDEDSLEEDSPRALGSGQHSDSHGESS 1376
             L   +       P  GP   AGP  +    ++  ++S  E S  +  S    ++    +
Sbjct: 571  SLGNILQAKPTSSPAKGPPQKAGPVAVQVKAEKPMDNS--ESSEESSDSADSEEAPAAMT 628

Query: 1377 AELDEQDILAPQTVQCPAQAPAGGSEETIAKAKQSRSEKKARKAMSKLGLRQ-IQGVTRI 1435
            A   +  +  PQT  CP +     S +       +++ +KA  A S  G    + G T+ 
Sbjct: 629  AAQAKPALKIPQTKACPKKTNTTASAKVAPVRVGTQAPRKAGTATSPAGSSPAVAGGTQR 688

Query: 1436 TIQKSKNILFVIAKPDVFKSPASDTYVVFGEAKIEDLSQQVHKAAAEKFK---------- 1485
              + S +     ++    +   +   V  G+AK      QV KAA+   K          
Sbjct: 689  PAEDSSS-----SEESDSEEEKTGLAVTVGQAKSVGKGLQV-KAASVPVKGSLGQGTAPV 742

Query: 1486 VPSEPSALVPESAPRPRVRLECKEEEEEEEEEVDEAGLELRDIELVMAQANVSRAKAVRA 1545
            +P +    V +     +   E  EEE + EE           ++   A+AN + A+A  A
Sbjct: 743  LPGKTGPTVTQVKAEKQEDSESSEEESDSEEAAASPAQVKTSVKKTQAKANPAAARAPSA 802


>gi|57164977 Treacher Collins-Franceschetti syndrome 1 isoform a [Homo
            sapiens]
          Length = 1450

 Score = 86.3 bits (212), Expect = 2e-16
 Identities = 198/981 (20%), Positives = 339/981 (34%), Gaps = 122/981 (12%)

Query: 510  ETDSTAGQESAAMAMPQPSQEGISEILGQESVTAEKLPTPQEETSLTLCPDSPQNLKEEG 569
            E D+    +   ++ P  + E   E    E+ TA+  P      S  L  D P ++KE+ 
Sbjct: 66   EEDAALQAKKTRVSDPISTSESSEEEEEAEAETAKATPRLASTNSSVLGADLPSSMKEKA 125

Query: 570  GLDLPSGRKPVAAATIVPRQAKEDLTLPQDSAMTPPLPLQDTDLSSAPKPVAAATIVSQQ 629
              +     K       +P  A         S  +P           + +P A  T+VS+ 
Sbjct: 126  KAETEKAGK---TGNSMPHPATGKTVANLLSGKSP---------RKSAEPSANTTLVSET 173

Query: 630  AEEGLTLPQDSVMTPPLPLQDTELSSAPKPVAAATLVSQQAEEGLTLPQDSAMTPPLPLQ 689
             EEG ++P       P  +   +  S+ +  ++++  +    +    P     +     +
Sbjct: 174  EEEG-SVPAFGAAAKPGMVSAGQADSSSEDTSSSSDETDVEGKPSVKPAQVKASSVSTKE 232

Query: 690  DTDLSSAPKPVAAATLVSQQAEEGLTLPQDSAMTPPLPLQDTDLSSAPKPVAAATLVSQQ 749
                 +AP P      V+ Q + G   P   A  P    + ++  S  +  A A   SQ 
Sbjct: 233  SPARKAAPAPGKVGD-VTPQVKGGALPPAKRAKKPEEESESSEEGSESEEEAPAGTRSQV 291

Query: 750  AEEGLTLPQDSAMTPPLPLQDTDLSSAPKPVAAATIVSQQAEEGLTLPQDSAMTPPLPLQ 809
                  L   +A  P         + AP   A A  V+ Q + G   P++ + +      
Sbjct: 292  KASEKILQVRAASAPAKGTPGKGATPAPPGKAGA--VASQTKAGK--PEEDSES-----S 342

Query: 810  DTDLSSAPKPVAAATIVSQQAEEGLTLPQDSAMTPPLPLQDTDLSSAPK----PVAAATP 865
              + S + +   AA  + Q    G T    +A  P         + AP     P  A   
Sbjct: 343  SEESSDSEEETPAAKALLQAKASGKTSQVGAASAPAKESPRKGAAPAPPGKTGPAVAKAQ 402

Query: 866  VSQQAEEGLTLPQDSAMTPPLPLQDTDLSSAPKPVAAATPVSQQAEEGLTLPQDSAMTAP 925
              ++ E+  +  ++S      P Q      AP+  AA+ P  +   +G          AP
Sbjct: 403  AGKREEDSQSSSEESDSEEEAPAQAKPSGKAPQVRAASAPAKESPRKG---------AAP 453

Query: 926  LPLQDTGPT-------------------SGPEPLAVATPQTLQAEA-GCAPGTEPVATMA 965
             P + TGP                    S  +  A+A     Q +  G +P  +P +TM 
Sbjct: 454  APPRKTGPAAAQVQVGKQEEDSRSSSEESDSDREALAAMNAAQVKPLGKSPQVKPASTMG 513

Query: 966  QQEVGEALGPRPAPEEKNAALPT--VPEPAALDQVQQDDPQPAAEAGTPWAAQEDADSTL 1023
               +G+  GP P P +   A P+  V +     +   ++   +++   P A     + +L
Sbjct: 514  MGPLGKGAGPVP-PGKVGPATPSAQVGKWEEDSESSSEESSDSSDGEVPTAVAPAQEKSL 572

Query: 1024 G--MEALSLPEPASGAGEEIAEALSRPGREACL---EARAHTGDGAKPDSPQKETLEVEN 1078
            G  ++A     PA G  ++      +   E  +   E+   + D A  DS +        
Sbjct: 573  GNILQAKPTSSPAKGPPQKAGPVAVQVKAEKPMDNSESSEESSDSA--DSEEAPAAMTAA 630

Query: 1079 QQEGGLKPLAQEHGPR--SALGGAREVPDAPPAACPEVSQARLLSPAREERGLSGKSTPE 1136
            Q +  LK    +  P+  +    A+  P       P  +     SPA     ++G  T  
Sbjct: 631  QAKPALKIPQTKACPKKTNTTASAKVAPVRVGTQAPRKA-GTATSPAGSSPAVAG-GTQR 688

Query: 1137 PTLPSAVATEASLDSCPESS-----VGAVSSLDRGCP--DAPAPTSAPTSQQPEPVL--- 1186
            P   S+ + E+  DS  E +     VG   S+ +G     A  P      Q   PVL   
Sbjct: 689  PAEDSSSSEES--DSEEEKTGLAVTVGQAKSVGKGLQVKAASVPVKGSLGQGTAPVLPGK 746

Query: 1187 --------------GLGSVEQPHEVPSVLGTPL---LQPPENLAKGQPSTPVDRPLGPDP 1229
                             S E+  +      +P        +  AK  P+           
Sbjct: 747  TGPTVTQVKAEKQEDSESSEEESDSEEAAASPAQVKTSVKKTQAKANPAAARAPSAKGTI 806

Query: 1230 SAPGTLAGAALPP-------LEPPAPCLCQDPQEDSVEDEEPPGSLGLPPPQAGVQPAAA 1282
            SAPG +  AA          ++PP     ++PQ  +V    P     +P     V  AA 
Sbjct: 807  SAPGKVVTAAAQAKQRSPSKVKPPV----RNPQNSTVLARGPAS---VPSVGKAVATAAQ 859

Query: 1283 AVSGTTQPLGTGPRVSLSPH-SPLLSPKVASMDAKDLALQILPPCQVPPPSGPQSPAGPQ 1341
            A +G  +  G+    S S   +  L+    S     +   + P  + P      +P G  
Sbjct: 860  AQTGPEEDSGSSEEESDSEEEAETLAQVKPSGKTHQIRAALAPAKESPRKGAAPTPPGKT 919

Query: 1342 GLSAPEQQEDEDSLEEDSPRALGSGQHSDSHGESSAELDEQDILAPQTVQCPAQAPAGGS 1401
            G SA +  + +DS          S + SDS GE+ A +    ++ P  +         G 
Sbjct: 920  GPSAAQAGKQDDSGS--------SSEESDSDGEAPAAVTSAQVIKPPLIFVDPNRSPAGP 971

Query: 1402 EETIAKAKQSRSEKKARKAMS 1422
              T A+A+ + + +KAR + S
Sbjct: 972  AATPAQAQAASTPRKARASES 992



 Score = 77.0 bits (188), Expect = 1e-13
 Identities = 248/1208 (20%), Positives = 410/1208 (33%), Gaps = 172/1208 (14%)

Query: 348  LAGEGEEDSTSASFLQSLSDLSITEGMDEAF---AFRDDTSAASSDSDSASYAEADDERL 404
            L+G+    S   S   +L   +  EG   AF   A     SA  +DS S   + + DE  
Sbjct: 152  LSGKSPRKSAEPSANTTLVSETEEEGSVPAFGAAAKPGMVSAGQADSSSEDTSSSSDETD 211

Query: 405  YSGEPHAQATLLQDSVQKTEEESGGGAKGLQAQDGTVSWAVEAAPQTSDRGAYLSQRQEL 464
              G+P  +   ++ S   T+E     A     + G V+  V+       + A   ++ E 
Sbjct: 212  VEGKPSVKPAQVKASSVSTKESPARKAAPAPGKVGDVTPQVKGGALPPAKRA---KKPEE 268

Query: 465  ISEVTEEGLALGQESTATVTPHTLQVAPGLQVEVATRVTPQAGEEETDSTAGQESAAMAM 524
             SE +EEG    +E+ A            LQV  A+   P  G     +T      A A+
Sbjct: 269  ESESSEEGSESEEEAPAGTRSQVKASEKILQVRAAS--APAKGTPGKGATPAPPGKAGAV 326

Query: 525  PQPSQEGISEILGQESVTAEKLPTPQEETSLTLCPDSPQNLKEEGGLDLPSGRKPVAAAT 584
               ++ G  E   + S  +E+    +EET     P +   L+ +      SG+     A 
Sbjct: 327  ASQTKAGKPEEDSESS--SEESSDSEEET-----PAAKALLQAKA-----SGKTSQVGAA 374

Query: 585  IVPRQAKEDLTLPQDSAMTPPLPLQDTDLSSAPKPVAAATIVSQQAEEGLTLPQDSVMTP 644
              P  AKE    P+  A   P             P  A     ++ E+  +  ++S    
Sbjct: 375  SAP--AKES---PRKGAAPAP--------PGKTGPAVAKAQAGKREEDSQSSSEESDSEE 421

Query: 645  PLPLQDTELSSAPKPVAAATLVSQQAEEGLTLPQDSAMTPPLPLQDTDLSSAPKPVAAAT 704
              P Q      AP+  AA+    +   +G           P P + T       P AA  
Sbjct: 422  EAPAQAKPSGKAPQVRAASAPAKESPRKG---------AAPAPPRKTG------PAAAQV 466

Query: 705  LVSQQAEEGLTLPQDS-----AMTPPLPLQDTDLSSAPKPVAAATLVSQQAEEGLTLPQD 759
             V +Q E+  +  ++S     A+      Q   L  +P+   A+T+      +G      
Sbjct: 467  QVGKQEEDSRSSSEESDSDREALAAMNAAQVKPLGKSPQVKPASTMGMGPLGKGAGPVPP 526

Query: 760  SAMTPPLPL-------QDTDLS------SAPKPVAAATIVSQQAEEGLTLPQDSAMTPPL 806
              + P  P        +D++ S      S+   V  A   +Q+   G  L      +P  
Sbjct: 527  GKVGPATPSAQVGKWEEDSESSSEESSDSSDGEVPTAVAPAQEKSLGNILQAKPTSSP-- 584

Query: 807  PLQDTDLSSAPKPVAAATIVSQQAEEGLTLPQDSAMTPPLPLQDTDLSSAPKPVAAATPV 866
                   +  P   A    V  +AE+    P D++ +        D   AP  + AA   
Sbjct: 585  -------AKGPPQKAGPVAVQVKAEK----PMDNSESSEESSDSADSEEAPAAMTAA--- 630

Query: 867  SQQAEEGLTLPQDSAMTPPLPLQDTDLSSAPKPVAAATPVSQQAEEGLTLPQDSAMTA-- 924
              QA+  L +PQ  A        +T  S+   PV   T   ++A    +    S   A  
Sbjct: 631  --QAKPALKIPQTKACPKK---TNTTASAKVAPVRVGTQAPRKAGTATSPAGSSPAVAGG 685

Query: 925  -PLPLQDTGPTSGPEPLAVATPQTLQAEAGCAPGTEPVATMAQQEVGEALGPRPAPEEKN 983
               P +D+  +   +     T   +      + G       A   V  +LG   AP    
Sbjct: 686  TQRPAEDSSSSEESDSEEEKTGLAVTVGQAKSVGKGLQVKAASVPVKGSLGQGTAPVLPG 745

Query: 984  AALPTVPEPAALDQVQQDDPQPAAEAGTPWAAQEDAD-STLGMEALSLPEPASGAGEEIA 1042
               PTV +  A  + Q+D      E+ +  AA   A   T   +  +   PA+       
Sbjct: 746  KTGPTVTQVKA--EKQEDSESSEEESDSEEAAASPAQVKTSVKKTQAKANPAAARAPSAK 803

Query: 1043 EALSRPGR--EACLEARAHTGDGAKPD--SPQKETL------EVENQQEGGLKPLAQEHG 1092
              +S PG+   A  +A+  +    KP   +PQ  T+       V +  +        + G
Sbjct: 804  GTISAPGKVVTAAAQAKQRSPSKVKPPVRNPQNSTVLARGPASVPSVGKAVATAAQAQTG 863

Query: 1093 PRSALGGAREVPDAPPAA--------CPEVSQAR-LLSPAREE-RGLSGKSTPEPTLPSA 1142
            P    G + E  D+   A          +  Q R  L+PA+E  R  +  + P  T PSA
Sbjct: 864  PEEDSGSSEEESDSEEEAETLAQVKPSGKTHQIRAALAPAKESPRKGAAPTPPGKTGPSA 923

Query: 1143 VATEASLDSCPESSVGAVSSLDRGCPDAPAPTSAPTSQQPEPVLGLGSVEQPHEVPSVLG 1202
                   DS         SS +    D  AP +  ++Q  +P L       P+  P+   
Sbjct: 924  AQAGKQDDS--------GSSSEESDSDGEAPAAVTSAQVIKPPL---IFVDPNRSPA--- 969

Query: 1203 TPLLQPPENLAKGQPSTPVDRPLGPDPSAPGTLAGAALPPLEPPAPCLCQDPQEDSVEDE 1262
                 P    A+ Q ++   +    + +A  + + +    + P   CL    + + V   
Sbjct: 970  ----GPAATPAQAQAASTPRKARASESTARSSSSESEDEDVIPATQCLTPGIRTNVVTMP 1025

Query: 1263 EPPGSLGLPPPQAGVQPA--AAAVSGTTQPLGTGPRVSLSPHS-PLLSPKVASMDAKDLA 1319
                 +      AG   +  ++ +S   +  G   +V  +  + P  SP+  S+ AK   
Sbjct: 1026 TAHPRIAPKASMAGASSSKESSRISDGKKQEGPATQVDSAVGTLPATSPQSTSVQAKG-- 1083

Query: 1320 LQILPPCQVPPPSGPQSPAGPQGLSAPEQQEDEDSLEEDSPRALGSGQHSDSHGESSAEL 1379
                          P+ P   Q   APE  +D +   + S     SG   D  G   A+ 
Sbjct: 1084 --------TNKLRKPKLPEVQQATKAPESSDDSEDSSDSS-----SGSEEDGEGPQGAK- 1129

Query: 1380 DEQDILAPQTVQCPAQAPAGGSEETIAK--AKQSRSEKKARKAMSKLGLRQIQGVTRITI 1437
                             P     ET+ +  A +S  +     + S L      G+T    
Sbjct: 1130 -----------SAHTLGPTPSRTETLVEETAAESSEDDVVAPSQSLLSGYMTPGLTPANS 1178

Query: 1438 QKSKNILFVIAKPDVFKSPASDTYVVF---GEAKIEDLSQQVHKAAAEKFKVPSEPSALV 1494
            Q SK      A P +  SP+  + +      + K E   QQ     + K       S   
Sbjct: 1179 QASK------ATPKLDSSPSVSSTLAAKDDPDGKQEAKPQQAAGMLSPKTGGKEAASGTT 1232

Query: 1495 PESAPRPR 1502
            P+ + +P+
Sbjct: 1233 PQKSRKPK 1240



 Score = 64.7 bits (156), Expect = 7e-10
 Identities = 155/780 (19%), Positives = 273/780 (35%), Gaps = 87/780 (11%)

Query: 809  QDTDLSSAPKPVAAATIVSQQAEEGLTLPQDSAM-TPPLPLQDTDLSSAPKPVAAATPVS 867
            +D  L +    V+     S+ +EE      ++A  TP L   ++ +  A  P +      
Sbjct: 67   EDAALQAKKTRVSDPISTSESSEEEEEAEAETAKATPRLASTNSSVLGADLPSSMKEKAK 126

Query: 868  QQAEE----GLTLPQDSA-MTPPLPLQDTDLSSAPKPVAAATPVSQQAEEGLTLPQDSAM 922
             + E+    G ++P  +   T    L       + +P A  T VS+  EEG ++P   A 
Sbjct: 127  AETEKAGKTGNSMPHPATGKTVANLLSGKSPRKSAEPSANTTLVSETEEEG-SVPAFGAA 185

Query: 923  TAPLPLQDTGPTSGPEPLAVATPQT-LQAEAGCAPGTEPVATMAQQEV-GEALGPRPA-- 978
              P  +      S  E  + ++ +T ++ +    P     ++++ +E       P P   
Sbjct: 186  AKPGMVSAGQADSSSEDTSSSSDETDVEGKPSVKPAQVKASSVSTKESPARKAAPAPGKV 245

Query: 979  ----PEEKNAALPTV-----PEPAALDQVQQDDPQPAAEAGTPWAAQEDADSTLGMEALS 1029
                P+ K  ALP       PE  +    +  + +  A AGT  +  + ++  L + A S
Sbjct: 246  GDVTPQVKGGALPPAKRAKKPEEESESSEEGSESEEEAPAGTR-SQVKASEKILQVRAAS 304

Query: 1030 LPEPAS-GAGEEIAEALSRPGREACLEARAHTGDGAKPDSPQKETLEVENQQEGGLKPL- 1087
             P   + G G   A     PG+   + ++   G   +      E      ++    K L 
Sbjct: 305  APAKGTPGKGATPAP----PGKAGAVASQTKAGKPEEDSESSSEESSDSEEETPAAKALL 360

Query: 1088 -AQEHGPRSALGGA----REVP-----DAPPAAC-PEVSQARLLSPAREERGLSGKSTPE 1136
             A+  G  S +G A    +E P      APP    P V++A+      + +  S +S  E
Sbjct: 361  QAKASGKTSQVGAASAPAKESPRKGAAPAPPGKTGPAVAKAQAGKREEDSQSSSEESDSE 420

Query: 1137 PTLPSAVATEASLDSCPESSVGAVSSLDRGCPDAPAPTSAPTSQQPEPVLGLGSVEQPHE 1196
               P+             +S  A  S  +G   AP   + P + Q +    +G  E+   
Sbjct: 421  EEAPAQAKPSGKAPQVRAASAPAKESPRKGAAPAPPRKTGPAAAQVQ----VGKQEEDSR 476

Query: 1197 VPSVLGTPLLQPPENLAKGQPSTPVDRPLGPDPSAPGTLAGAALPPLEPPAPCLCQDPQE 1256
              S          +  A    +    +PLG  P                PA  +   P  
Sbjct: 477  SSSEESDS-----DREALAAMNAAQVKPLGKSPQVK-------------PASTMGMGPLG 518

Query: 1257 DSVEDEEPPGSLGLPPPQAGVQPAAAAVSGTTQPLGTGPRVSLSPHSPLLSPKVASMDAK 1316
                     G+  +PP + G    +A V    +   +    S       +   VA    K
Sbjct: 519  K--------GAGPVPPGKVGPATPSAQVGKWEEDSESSSEESSDSSDGEVPTAVAPAQEK 570

Query: 1317 DLALQILPPCQVPPPSGPQSPAGPQGLSAPEQQEDEDSLEEDSPRALGSGQHSDSHGESS 1376
             L   +       P  GP   AGP  +    ++  ++S  E S  +  S    ++    +
Sbjct: 571  SLGNILQAKPTSSPAKGPPQKAGPVAVQVKAEKPMDNS--ESSEESSDSADSEEAPAAMT 628

Query: 1377 AELDEQDILAPQTVQCPAQAPAGGSEETIAKAKQSRSEKKARKAMSKLGLR-QIQGVTRI 1435
            A   +  +  PQT  CP +     S +       +++ +KA  A S  G    + G T+ 
Sbjct: 629  AAQAKPALKIPQTKACPKKTNTTASAKVAPVRVGTQAPRKAGTATSPAGSSPAVAGGTQR 688

Query: 1436 TIQKSKNILFVIAKPDVFKSPASDTYVVFGEAKIEDLSQQVHKAAAEKFK---------- 1485
              + S +     ++    +   +   V  G+AK      QV KAA+   K          
Sbjct: 689  PAEDSSS-----SEESDSEEEKTGLAVTVGQAKSVGKGLQV-KAASVPVKGSLGQGTAPV 742

Query: 1486 VPSEPSALVPESAPRPRVRLECKEEEEEEEEEVDEAGLELRDIELVMAQANVSRAKAVRA 1545
            +P +    V +     +   E  EEE + EE           ++   A+AN + A+A  A
Sbjct: 743  LPGKTGPTVTQVKAEKQEDSESSEEESDSEEAAASPAQVKTSVKKTQAKANPAAARAPSA 802


>gi|149773456 hypothetical protein LOC643314 [Homo sapiens]
          Length = 1427

 Score = 84.7 bits (208), Expect = 6e-16
 Identities = 142/568 (25%), Positives = 201/568 (35%), Gaps = 53/568 (9%)

Query: 738  KPVAAATLVSQQAEEGLTLPQDSAMTPPLPLQDTDLSSA-PKPVAAATIVSQQAEEGLTL 796
            K V  A       EE + + Q  + T  +P     L +A P P    +I +  A EG  +
Sbjct: 812  KQVTKAGNTEPVLEEWIPVLQRPSRTAAVPTVKDALDAALPSPEEGTSIAAVPAPEGTAV 871

Query: 797  PQDSAMTPPLPLQDTDLSSA----PKPVAAATIVSQQAEEGLTLPQDSAMTPPLPLQDTD 852
                A   P P +D  ++S      + V AA +    A E  T+P  +   P        
Sbjct: 872  V---AALVPFPHEDILVASIVSLEEEDVTAAAV---SAPERATVPAVTVSVPEGTAAVAA 925

Query: 853  LSS----APKPVAAATPVSQQAEEGLTLPQDSAMTPPLPLQDTDLSSAPKPVAAATPVSQ 908
            +SS    AP   AA T     A  G + P+ +A+   +P+ + D  +   PV  AT V  
Sbjct: 926  VSSPEETAPAVAAAITQEGMSAVAGFS-PEWAALAITVPITEED-GTPEGPVTPATTVHA 983

Query: 909  QAEEGLTLPQDSAMTAPLPLQDTGPTSGPEPLAVATPQTLQAEAGCAPGTEPVATMAQQE 968
              E     P  +A+    P +   P +     AV TP+   + A   P  E   + A   
Sbjct: 984  PEE-----PDTAAVRVSTPEEPASPAA-----AVPTPEEPTSPAAAVPTPEEPTSPAA-- 1031

Query: 969  VGEALGPRPAPEEKNAALPTVPEP---AALDQVQQDDPQPAAEAGTPWAAQEDADSTLGM 1025
               A+ P   P    AA+PT  EP   AA     ++   PAA   TP      A +    
Sbjct: 1032 ---AVPPPEEPTSPAAAVPTPEEPTSPAAAVPTPEEPTSPAAAVPTPEEPTSPAAAVPTP 1088

Query: 1026 EALSLPEPASGAGEEI---AEALSRPGREACLEARAHTGDGAKPDSPQKETLEVENQQEG 1082
            E  + P  A    EE    A A+  P   A   A   T     P+ P      V   +E 
Sbjct: 1089 EEPTSPAAAVPTPEEPTSPAAAVPTPEEPASPAAAVPT-----PEEPASPAAAVPTPEEP 1143

Query: 1083 GLKPLAQEHGPRSALGGAREVPDAPPAACPEVSQARLLSPAREERGLSGKST-PEPTLPS 1141
               P      P  +   A  VP    +A P    A + +PA      +  +T  EPT P+
Sbjct: 1144 AF-PAPAVPTPEESASAAVAVPTPEESASPA---AAVPTPAESASFAAVVATLEEPTSPA 1199

Query: 1142 A-VATEASLDSCPESSVGAVSSLDRGCPDAPAPTSAPTSQQPEPVLGLGSVEQPHEVPSV 1200
            A V T A++ +  E      +S+     + PA  +A  S   EP     +V    E  S 
Sbjct: 1200 ASVPTPAAMVATLEEFTSPAASVPTS--EEPASLAAAVSNPEEPTSPAAAVPTLEEPTSS 1257

Query: 1201 LGTPLLQPPENLAKGQPSTPVDRPLGPDPSAPGTLAGAALPPLEPPAPCLCQDPQEDSVE 1260
                L   PE L+    S P         +A   L   A P    P P +   P      
Sbjct: 1258 AAAVLT--PEELSSPAASVPTPEEPASPAAAVSNLEEPASPAAAVPTPEVAAIPAASVPT 1315

Query: 1261 DEEPPGSLGLPPPQAGVQPAAAAVSGTT 1288
             E P       PP   V P      G +
Sbjct: 1316 PEVPAIPAAAVPPMEEVSPIGVPFLGVS 1343



 Score = 84.0 bits (206), Expect = 1e-15
 Identities = 142/590 (24%), Positives = 211/590 (35%), Gaps = 106/590 (17%)

Query: 698  KPVAAATLVSQQAEEGLTLPQDSAMTPPLPLQDTDLSSA-PKPVAAATLVSQQAEEGLTL 756
            K V  A       EE + + Q  + T  +P     L +A P P    ++ +  A EG  +
Sbjct: 812  KQVTKAGNTEPVLEEWIPVLQRPSRTAAVPTVKDALDAALPSPEEGTSIAAVPAPEGTAV 871

Query: 757  PQDSAMTPPLPLQDTDLSSA----PKPVAAATIVSQQAEEGLTLPQDSAMTPPLPLQDTD 812
                A   P P +D  ++S      + V AA +    A E  T+P  +   P        
Sbjct: 872  V---AALVPFPHEDILVASIVSLEEEDVTAAAV---SAPERATVPAVTVSVPEGTAAVAA 925

Query: 813  LSS----APKPVAAATIVSQQAEEGLTLPQDSAMTPPLPLQDTDLSSAPKPVAAATPVSQ 868
            +SS    AP   AA T     A  G + P+ +A+   +P+ + D  +   PV  AT V  
Sbjct: 926  VSSPEETAPAVAAAITQEGMSAVAGFS-PEWAALAITVPITEED-GTPEGPVTPATTVHA 983

Query: 869  QAEEGLTLPQDSAMTPPLPLQDTDLSSAPKPVAAATPVSQQAEEGLTLPQDSAMTAPLPL 928
              E     P  +A+    P +       P   AAA P  ++       P   A   P P 
Sbjct: 984  PEE-----PDTAAVRVSTPEE-------PASPAAAVPTPEE-------PTSPAAAVPTPE 1024

Query: 929  QDTGPTSGPEP--------LAVATPQTLQAEAGCAP----GTEPVATM-AQQEVGEALGP 975
            + T P +   P         AV TP+   + A   P     T P A +   +E       
Sbjct: 1025 EPTSPAAAVPPPEEPTSPAAAVPTPEEPTSPAAAVPTPEEPTSPAAAVPTPEEPTSPAAA 1084

Query: 976  RPAPEEKN---AALPTVPE---PAALDQVQQDDPQPAAEAGTPWAAQEDADSTLGMEALS 1029
             P PEE     AA+PT  E   PAA     ++   PAA   TP      A +    E  +
Sbjct: 1085 VPTPEEPTSPAAAVPTPEEPTSPAAAVPTPEEPASPAAAVPTPEEPASPAAAVPTPEEPA 1144

Query: 1030 LPEPASGAGEEIAEALSRPGREACLEARAHTGDGAKPDSPQKETLEVENQQEGGLKPLAQ 1089
             P PA    EE A A                       +P+      E+       P   
Sbjct: 1145 FPAPAVPTPEESASA------------------AVAVPTPE------ESASPAAAVPTPA 1180

Query: 1090 EHGPRSALGGAREVPDAPPAACPEVSQARLLSPAREERGLSGKSTPEPTLPSAVATEASL 1149
            E    +A+    E P +P A+ P  +    +    EE      S P    P+++A   S 
Sbjct: 1181 ESASFAAVVATLEEPTSPAASVPTPA---AMVATLEEFTSPAASVPTSEEPASLAAAVSN 1237

Query: 1150 DSCPESSVGAVSSLDRGCPDAPA----------PTSAPTSQQP-EPVLGLGSVEQPHEVP 1198
               P S   AV +L+     A A            S PT ++P  P   + ++E+P    
Sbjct: 1238 PEEPTSPAAAVPTLEEPTSSAAAVLTPEELSSPAASVPTPEEPASPAAAVSNLEEPASPA 1297

Query: 1199 SVLGTPLLQPPENLAKGQPSTPVDRPLGPDPSAPGTLAGAALPPLEPPAP 1248
            + + TP +          P+  V     P P  P  +  AA+PP+E  +P
Sbjct: 1298 AAVPTPEV-------AAIPAASV-----PTPEVP-AIPAAAVPPMEEVSP 1334



 Score = 58.2 bits (139), Expect = 6e-08
 Identities = 109/496 (21%), Positives = 177/496 (35%), Gaps = 84/496 (16%)

Query: 962  ATMAQQEVGEALGPRPAPEEKNAALPTVPEP------AALDQVQQDDPQPAA-----EAG 1010
            A +   E G ++   PAPE        VP P      A++  ++++D   AA      A 
Sbjct: 849  AALPSPEEGTSIAAVPAPEGTAVVAALVPFPHEDILVASIVSLEEEDVTAAAVSAPERAT 908

Query: 1011 TPWAAQEDADSTLGMEALSLPEPASGAGEEIAEALSRPGREACLEARAHTGDGAKPD--- 1067
             P       + T  + A+S PE  + A   +A A+++ G  A          G  P+   
Sbjct: 909  VPAVTVSVPEGTAAVAAVSSPEETAPA---VAAAITQEGMSAVA--------GFSPEWAA 957

Query: 1068 -SPQKETLEVENQQEGGLKPLAQEHGPRSALGGAREVPDAPPAACPEVSQARLLSPAREE 1126
             +      E +   EG + P    H P                  P+ +  R+ +P  EE
Sbjct: 958  LAITVPITEEDGTPEGPVTPATTVHAPEE----------------PDTAAVRVSTP--EE 999

Query: 1127 RGLSGKSTPEPTLPSAVATEASLDSCPESSVGAVSSLDRGCPDAPAPTSAPTSQQP-EPV 1185
                  + P P  P++ A        P S   AV   +   P +PA  + PT ++P  P 
Sbjct: 1000 PASPAAAVPTPEEPTSPAAAVPTPEEPTSPAAAVPPPEE--PTSPA-AAVPTPEEPTSPA 1056

Query: 1186 LGLGSVEQPHEVPSVLGTPLLQPPENLAKGQPSTPVDRPLGPDPSAPGTLAGAALP-PLE 1244
              + + E+P    + + TP           +P++P      P P  P T   AA+P P E
Sbjct: 1057 AAVPTPEEPTSPAAAVPTP----------EEPTSPAAAV--PTPEEP-TSPAAAVPTPEE 1103

Query: 1245 PPAPCLCQDPQED------SVEDEEPPGS--LGLPPPQAGVQPAAAA----VSGTTQPLG 1292
            P +P       E+      +V   E P S    +P P+    PA A      S +     
Sbjct: 1104 PTSPAAAVPTPEEPASPAAAVPTPEEPASPAAAVPTPEEPAFPAPAVPTPEESASAAVAV 1163

Query: 1293 TGPRVSLSPHSPLLSPKVASMDAKDLAL---QILPPCQVPPPSGPQSPAGPQGLSAPEQQ 1349
              P  S SP + + +P  ++  A  +A       P   VP P+     A  +  ++P   
Sbjct: 1164 PTPEESASPAAAVPTPAESASFAAVVATLEEPTSPAASVPTPAA--MVATLEEFTSPAAS 1221

Query: 1350 EDEDSLEEDSPRALGSGQHSDSHGESSAELDEQD-----ILAPQTVQCPAQAPAGGSEET 1404
                        A+ + +   S   +   L+E       +L P+ +  PA +     E  
Sbjct: 1222 VPTSEEPASLAAAVSNPEEPTSPAAAVPTLEEPTSSAAAVLTPEELSSPAASVPTPEEPA 1281

Query: 1405 IAKAKQSRSEKKARKA 1420
               A  S  E+ A  A
Sbjct: 1282 SPAAAVSNLEEPASPA 1297


>gi|32455273 WNK lysine deficient protein kinase 2 [Homo sapiens]
          Length = 2217

 Score = 82.0 bits (201), Expect = 4e-15
 Identities = 183/763 (23%), Positives = 262/763 (34%), Gaps = 157/763 (20%)

Query: 687  PLQDTDLSSAPK----PVAAATLVSQQAEEGLTLPQDSAMTPPLPLQDTDLSSAPKPVAA 742
            P +  D+ S  K    PV     V+  A+ G   P +    P  P  D  L     P +A
Sbjct: 552  PKEQQDVGSPDKARGPPVPLQVQVTYHAQAGQPGPPE----PEEPEADQHLLPPTLPTSA 607

Query: 743  ATLVSQQ---AEEGLTLPQDSAMTPPLPLQDTDLSSAPKPVAAATIVSQQAEEGLTLPQD 799
             +L S     + +G T+  DS  +    +  +   +AP P  A  + S    EG  LPQ 
Sbjct: 608  TSLASDSTFDSGQGSTVYSDSQSSQQSVMLGSLADAAPSP--AQCVCSPPVSEGPVLPQS 665

Query: 800  ----SAMTPPLPLQDTDLSSAPKPVAAATIVSQQAEEGLT----LPQDSAMTPPLPLQDT 851
                 A   P       + S P P    ++     +  ++    LP  S   P  P Q  
Sbjct: 666  LPSLGAYQQPTAAPGLPVGSVPAPACPPSLQQHFPDPAMSFAPVLPPPSTPMPTGPGQPA 725

Query: 852  DLSSAPKPVAAATPVSQQAEEGLTLPQDSAMTPPLPLQDTDLSSAPKPVAAATPVSQQAE 911
                 P P+A  TP          LPQ  A  P +PLQ       P  +A A+ V   A+
Sbjct: 726  PPGQQPPPLAQPTP----------LPQVLAPQPVVPLQPVP-PHLPPYLAPASQVGAPAQ 774

Query: 912  -EGLTLPQDSAMTAPLPLQDTGPTSGPEPLAVATPQTLQAEAGCAPGTEPVATMAQQEVG 970
             + L +PQ     APL           +PLA   PQ         P   P+  +A    G
Sbjct: 775  LKPLQMPQ-----APL-----------QPLAQVPPQMPP-----IPVVPPITPLA----G 809

Query: 971  EALGPRPAPEEKNAALPTVPEPAALDQVQQDDPQPAAEAGTPWAAQEDADSTLGMEALSL 1030
                P   P+   A +P VP P            PA    +  A    A   L ++A+ L
Sbjct: 810  IDGLPPALPDLPTATVPPVPPPQYF--------SPAVILPSLAAPLPPASPALPLQAVKL 861

Query: 1031 PEPASGAGEEIAEALSRPGREACLEARAHTGDGAKPDSPQKETLEVENQQEGGLKPLAQE 1090
            P P              PG    +  R        P++P   T+ +      G+  L   
Sbjct: 862  PHP--------------PGAPLAMPCRT-----IVPNAP--ATIPLLAVAPPGVAAL--- 897

Query: 1091 HGPRSALGGAREVPDAP--PAACPEVSQARLLSPAREERGLSGKSTPEPTLPSAVATEAS 1148
                S      ++P  P  PAA P+++   +             + P+P LP        
Sbjct: 898  ----SIHSAVAQLPGQPVYPAAFPQMAPTDVPPSPHHTVQNMRATPPQPALP-------- 945

Query: 1149 LDSCPESSVGAVSSLDRGCPDAPAPTSAPTSQQPEPVLGLGSVEQPHEVPS-VLGTPLLQ 1207
                P+ ++          P  P     PT   P+PVL      QP   P  VL    + 
Sbjct: 946  ----PQPTL----------PPQPVLPPQPT-LPPQPVL----PPQPTRPPQPVLPPQPML 986

Query: 1208 PPENLAKGQPSTPVDRPLGPDPSAPGTLAGAALPP----LEPPAPCLCQDPQEDSVEDEE 1263
            PP+ +   QP+ PV RP    P  P   A AA P     L  PAP    D          
Sbjct: 987  PPQPVLPPQPALPV-RPEPLQPHLPEQAAPAATPGSQILLGHPAP-YAVDVAAQVPTVPV 1044

Query: 1264 PPGSLGLPPPQAGVQPAAAAVSGTTQPLGTGPRVSLSPHSPLLSPKVASMDAKDLALQIL 1323
            PP ++  PP    + PAA             P +     S L +   +          +L
Sbjct: 1045 PPAAVLSPPLPEVLLPAA-------------PELLPQFPSSLATVSASVQSVPTQTATLL 1091

Query: 1324 PPCQVPPPSGP--QSPAGPQGLSAPEQQEDEDSLEEDSPRALGSGQHSDSHGESSAELDE 1381
            PP   P P GP   SP     L+    QE++ S  +D P   G  Q  +S+G S      
Sbjct: 1092 PPANPPLPGGPGIASPCPTVQLTVEPVQEEQAS--QDKPP--GLPQSCESYGGS------ 1141

Query: 1382 QDILAPQTVQCPAQAPAGGSE-ETIAKAKQSRSEKKARKAMSK 1423
             D+ + + +    +   GG   E  A  K  R   +AR    +
Sbjct: 1142 -DVTSGKELSDSCEGAFGGGRLEGRAARKHHRRSTRARSRQER 1183



 Score = 74.7 bits (182), Expect = 6e-13
 Identities = 217/950 (22%), Positives = 324/950 (34%), Gaps = 148/950 (15%)

Query: 478  ESTATVTPHTLQVAPGLQVEVATRVTPQAGEEETDSTAGQESAAM-----AMPQPSQEGI 532
            E+   + P TL  +       +T  + Q     +DS + Q+S  +     A P P+Q   
Sbjct: 593  EADQHLLPPTLPTSATSLASDSTFDSGQGSTVYSDSQSSQQSVMLGSLADAAPSPAQCVC 652

Query: 533  SEILGQESVTAEKLPT-------------PQEETSLTLCPDSPQNLKEEGGLD------- 572
            S  + +  V  + LP+             P        CP S Q    +  +        
Sbjct: 653  SPPVSEGPVLPQSLPSLGAYQQPTAAPGLPVGSVPAPACPPSLQQHFPDPAMSFAPVLPP 712

Query: 573  ----LPSGRKPVAAATIVPRQAKEDLTLPQDSAMTPPLPLQDTDLSSAPKPVAAATIVSQ 628
                +P+G    A     P    +   LPQ  A  P +PLQ       P    A+ + + 
Sbjct: 713  PSTPMPTGPGQPAPPGQQPPPLAQPTPLPQVLAPQPVVPLQPVPPHLPPYLAPASQVGAP 772

Query: 629  QAEEGLTLPQDSVMTPPLPLQDTELSSAPKPVAAATLVSQQAEEGL--TLPQ-DSAMTPP 685
               + L +PQ     P  PL        P PV    +      +GL   LP   +A  PP
Sbjct: 773  AQLKPLQMPQ----APLQPLAQVPPQMPPIPV-VPPITPLAGIDGLPPALPDLPTATVPP 827

Query: 686  LPLQDTDLSSAPKPVAAATLVSQQAEEGLTLPQDSAMTPPLPLQDTDLSSAPKPVAAATL 745
            +P         P+  + A ++   A     LP  S   P LPLQ   L   P P  A   
Sbjct: 828  VP--------PPQYFSPAVILPSLA---APLPPAS---PALPLQAVKL---PHPPGAPLA 870

Query: 746  VSQQAEEGLTLPQDSAMTPPLPLQDTDLSSAPKPVAAATIVSQQAEEGLTLPQDSAMTPP 805
            +  +     T+  ++  T PL      L+ AP  VAA +I S  A+    LP        
Sbjct: 871  MPCR-----TIVPNAPATIPL------LAVAPPGVAALSIHSAVAQ----LPGQPVYPAA 915

Query: 806  LP-LQDTDLSSAPKPVA---AATIVSQQAEEGLTLPQDSAM-----TPPLPLQDTDLSSA 856
             P +  TD+  +P        AT          TLP    +      PP P+     +  
Sbjct: 916  FPQMAPTDVPPSPHHTVQNMRATPPQPALPPQPTLPPQPVLPPQPTLPPQPVLPPQPTRP 975

Query: 857  PKPVAAATPVSQQAEEGLTLPQDSAMTPPLPLQDTDLSSAPKPVAAATPVSQQAEEGLTL 916
            P+PV    P+     + +  PQ +    P PLQ       P+  A A     Q   G   
Sbjct: 976  PQPVLPPQPM--LPPQPVLPPQPALPVRPEPLQ----PHLPEQAAPAATPGSQILLGHPA 1029

Query: 917  PQDSAMTAPLPLQDTGPTSG-----PEPLAVATPQTL----QAEAGCAPGTEPVATMAQQ 967
            P    + A +P     P +      PE L  A P+ L     + A  +   + V T    
Sbjct: 1030 PYAVDVAAQVPTVPVPPAAVLSPPLPEVLLPAAPELLPQFPSSLATVSASVQSVPTQTAT 1089

Query: 968  EVGEALGPRPAPEEKNAALPTVP---EPAALDQVQQDDPQPAAEAGTPWAAQE--DADST 1022
             +  A  P P      +  PTV    EP   +Q  QD P      G P + +    +D T
Sbjct: 1090 LLPPANPPLPGGPGIASPCPTVQLTVEPVQEEQASQDKP-----PGLPQSCESYGGSDVT 1144

Query: 1023 LGMEALSLPEPASGAGEEIAEALSRPGREACLEARAHTGDGAKPDSPQKETLEVENQQEG 1082
             G E     E A G G     A  +  R +   AR+      +   P+   L V N  + 
Sbjct: 1145 SGKELSDSCEGAFGGGRLEGRAARKHHRRS-TRARSRQ---ERASRPRLTILNVCNTGDK 1200

Query: 1083 GLKPLAQEHGPRSALGGAREVPDAPPAACPEVSQARLLSPAREERGLSGKSTPEPTLPSA 1142
             ++   + H  +          DAP      + +   +  A  E  +             
Sbjct: 1201 MVECQLETHNHKMVTFKFDLDGDAPDEIATYMVEHDFILQAERETFIEQMKDVMDKAEDM 1260

Query: 1143 VA--TEASLDSCPESSVGAVSS--LDRGCPDAPAPTSAPTSQQPE-----------PVLG 1187
            ++  T+A   S P +S   +S+  L  G     +  +AP  QQ             PV  
Sbjct: 1261 LSEDTDADRGSDPGTSPPHLSTCGLGTGEESRQSQANAPVYQQNVLHTGKRWFIICPVAE 1320

Query: 1188 LGSVEQPHEVPSVLGTPLLQPPENLAKGQPSTPVDRPLGPDPSAPGTL--------AGAA 1239
              + E P   P +  + L  PPE     Q S P    L      P  L        AG +
Sbjct: 1321 HPAPEAPESSPPLPLSSL--PPE---ASQDSAPYKDQLS-SKEQPSFLASQQLLSQAGPS 1374

Query: 1240 LPPLEPPAPCLCQDPQEDSV-EDEEPPGSLGLPPPQAGVQPAA---AAVSGTTQPLGTGP 1295
             PP  PPAP     P   ++ +D   P +  +P P +G    A       G T  L T  
Sbjct: 1375 NPPGAPPAPLAPSSPPVTALPQDGAAPATSTMPEPASGTASQAGGPGTPQGLTSELETSQ 1434

Query: 1296 RVSLSPHSPL--------LSPKVASMDAKDLALQILPPCQVPPPSGPQSP 1337
             ++ +  +PL        L+P   + +A        P   +PPP+   SP
Sbjct: 1435 PLAETHEAPLAVQPLVVGLAPCTPAPEAASTRDASAPREPLPPPAPEPSP 1484



 Score = 54.3 bits (129), Expect = 9e-07
 Identities = 157/684 (22%), Positives = 236/684 (34%), Gaps = 117/684 (17%)

Query: 563  QNLKEEGGLDLPSGRKPVAAATIVPRQAKEDLTLPQDSAMTPPLPLQDTDLSSAPKPVAA 622
            Q L  + G   P G  P   A   P        LPQD A      + +    +A +    
Sbjct: 1365 QQLLSQAGPSNPPGAPPAPLAPSSPPVT----ALPQDGAAPATSTMPEPASGTASQAGGP 1420

Query: 623  ATIVSQQAEEGLTLPQDSVMTPPLPLQDTELSSAP---KPVAAATLVSQQAEEGLTLPQD 679
             T     +E   + P       PL +Q   +  AP    P AA+T  +    E L  P  
Sbjct: 1421 GTPQGLTSELETSQPLAETHEAPLAVQPLVVGLAPCTPAPEAASTRDASAPREPLPPPAP 1480

Query: 680  SAMT---PPLPLQDTDLSSAPKPVAAATLVSQQAEE---GLTLPQDSAMTPPLPLQDTDL 733
                    P P         P  V A +L + Q      G T+P      PP  L+    
Sbjct: 1481 EPSPHSGTPQPALGQPAPLLPAAVGAVSLATSQLPSPPLGPTVPPQ----PPSALESDGE 1536

Query: 734  SSAPKPVAAATLVSQQAEEGLTL------PQDSAMT-PPLPLQDTDLSSAPK-------- 778
               P+     + +    E+  TL      P  SA    P+ + D D +  P         
Sbjct: 1537 GPPPRVGFVDSTIKSLDEKLRTLLYQEHVPTSSASAGTPVEVGDRDFTLEPLRGDQPRSE 1596

Query: 779  --------PVAAATIVSQQAEEGLTLPQDSAMTPPL-PLQDTDLSSAPKPVAAATIVSQQ 829
                    P      VS + +    L + S + P    + +   SS+    ++   +   
Sbjct: 1597 VCGGDLALPPVPKEAVSGRVQLPQPLVEKSELAPTRGAVMEQGTSSSMTAESSPRSMLGY 1656

Query: 830  AEEGLTLPQDSAMTPPLP-----------LQDTDL-------SSAPKPVAAATPVSQQAE 871
              +G  +  DS + P +P           ++ TD        SSA  P +    V  QA 
Sbjct: 1657 DRDGRQVASDSHVVPSVPQDVPAFVRPARVEPTDRDGGEAGESSAEPPPSDMGTVGGQAS 1716

Query: 872  EGLTLPQDSAMTPPLPLQDTDLSSAPKPVAAATPVSQQAEEGLTLPQDSAMTAPLPLQ-D 930
               TL   +  +P    +  D+SS  K V   + VS Q E  L  P     +AP  +  D
Sbjct: 1717 HPQTLGARALGSPRKRPEQQDVSSPAKTVGRFSVVSTQDEWTLASPHSLRYSAPPDVYLD 1776

Query: 931  TGPTSGPEPLAVATPQTLQA-EAGCAPGTEPVATMAQQEVGEALGPRPAPE-EKNAALPT 988
              P+S    LAV   QT  + E G     EPV++ +  E     GPR  P  +K A+LP 
Sbjct: 1777 EAPSSPDVKLAVRRAQTASSIEVGVG---EPVSSDSGDE-----GPRARPPVQKQASLP- 1827

Query: 989  VPEPAALDQVQQ-----DDPQPAAEAG----------------TPWAAQ----------- 1016
            V    A D V++       P  A   G                T + +Q           
Sbjct: 1828 VSGSVAGDFVKKATAFLQRPSRAGSLGPETPSRVGMKVPTISVTSFHSQSSYISSDNDSE 1887

Query: 1017 -EDADSTLGMEAL------SLPEPASGAGEEIAEALSRPGREACLEARAHTGDGAKPDSP 1069
             EDAD    +++L       + E  S   +EI     R G+   L         A P   
Sbjct: 1888 LEDADIKKELQSLREKHLKEISELQSQQKQEIEALYRRLGKP--LPPNVGFFHTAPPTGR 1945

Query: 1070 QKETLEVENQQEGGLKPLAQE-HGPRSALGGAREVPDAPPAACPEVSQARLLSPAREERG 1128
            +++T + + +    L PL ++     S+ G   +    PPA  P  +   L +   +  G
Sbjct: 1946 RRKTSKSKLKAGKLLNPLVRQLKVVASSTGHLADSSRGPPAKDPAQASVGLTA---DSTG 2002

Query: 1129 LSGKSTPEPTLPSAVATEASLDSC 1152
            LSGK+  +   P +V    S D C
Sbjct: 2003 LSGKAV-QTQQPCSVRASLSSDIC 2025



 Score = 46.6 bits (109), Expect = 2e-04
 Identities = 92/401 (22%), Positives = 134/401 (33%), Gaps = 86/401 (21%)

Query: 1062 DGAKPDSPQKETLEVENQQEG-GLKPLAQEHGPRSALGGAREVPDAPPAACPEVSQARLL 1120
            + ++  +P K+ L  + Q      + L  + GP +        P APPA     S     
Sbjct: 1341 EASQDSAPYKDQLSSKEQPSFLASQQLLSQAGPSNP-------PGAPPAPLAPSSPPVTA 1393

Query: 1121 SPAREERGLSGKSTPEPTLPSAVATEASLDSCPESSVGAVSSLDRGCPDAPAPTSAPTSQ 1180
             P        G +    T+P   +  AS    P +  G  S L+         TS P ++
Sbjct: 1394 LPQ------DGAAPATSTMPEPASGTASQAGGPGTPQGLTSELE---------TSQPLAE 1438

Query: 1181 QPEPVLGLGSVEQPHEVPSVLGTPLLQPPENLAKGQPSTPVDRPLGPDPSAPGTLAGAAL 1240
              E  L +         P V+G     P    A  + ++    PL P    P   +G   
Sbjct: 1439 THEAPLAVQ--------PLVVGLAPCTPAPEAASTRDASAPREPLPPPAPEPSPHSGTPQ 1490

Query: 1241 PPLEPPAPCL-------------CQDPQEDSVEDEEPPGSLGL----PPPQAGV------ 1277
            P L  PAP L                P        +PP +L      PPP+ G       
Sbjct: 1491 PALGQPAPLLPAAVGAVSLATSQLPSPPLGPTVPPQPPSALESDGEGPPPRVGFVDSTIK 1550

Query: 1278 --------------QPAAAAVSGTTQPLGTGPRVSLSPHSPLLSPKVAS-MDAKDLALQI 1322
                           P ++A +GT  P+  G R       PL   +  S +   DLAL  
Sbjct: 1551 SLDEKLRTLLYQEHVPTSSASAGT--PVEVGDRDFTL--EPLRGDQPRSEVCGGDLALPP 1606

Query: 1323 LPP------CQVPPPSGPQSPAGPQGLSAPEQQEDEDSLEEDSPRAL------GSGQHSD 1370
            +P        Q+P P   +S   P   +  EQ        E SPR++      G    SD
Sbjct: 1607 VPKEAVSGRVQLPQPLVEKSELAPTRGAVMEQGTSSSMTAESSPRSMLGYDRDGRQVASD 1666

Query: 1371 SHGESSAELDEQDILAPQTVQCPAQAPAGGSEETIAKAKQS 1411
            SH   S   D    + P  V+ P     G + E+ A+   S
Sbjct: 1667 SHVVPSVPQDVPAFVRPARVE-PTDRDGGEAGESSAEPPPS 1706



 Score = 45.8 bits (107), Expect = 3e-04
 Identities = 57/209 (27%), Positives = 77/209 (36%), Gaps = 17/209 (8%)

Query: 13   PEADRPGPRTDLSCDAAAATTILGGDRREPCALTPGPSHLALTFLPSKPGARPQPEGASW 72
            PE+  P P + L  +A+  +       ++  +    PS LA   L S+ G    P     
Sbjct: 1327 PESSPPLPLSSLPPEASQDSA----PYKDQLSSKEQPSFLASQQLLSQAGPSNPPGAPPA 1382

Query: 73   DAGPGGAPSAWADPGEGGPSPMLLPEGLSSQALSTEAPLPATLEPRIVMGE-ETCQALLS 131
               P   P          P+   +PE  S  A  ++A  P T  P+ +  E ET Q L  
Sbjct: 1383 PLAPSSPPVTALPQDGAAPATSTMPEPASGTA--SQAGGPGT--PQGLTSELETSQPLAE 1438

Query: 132  PRAARTALRDQEGGHASPDPPPELCSQGDLSVPS---PPPDPDSFFTPPSTPTKTTYALL 188
               A  A++    G A   P PE  S  D S P    PPP P+     PS  + T    L
Sbjct: 1439 THEAPLAVQPLVVGLAPCTPAPEAASTRDASAPREPLPPPAPE-----PSPHSGTPQPAL 1493

Query: 189  PACGPHGDARDSEAELRDELLDSPPASPS 217
                P   A      L    L SPP  P+
Sbjct: 1494 GQPAPLLPAAVGAVSLATSQLPSPPLGPT 1522



 Score = 45.4 bits (106), Expect = 4e-04
 Identities = 97/407 (23%), Positives = 151/407 (37%), Gaps = 49/407 (12%)

Query: 437  QDGTV---SWAVEAAPQTSDRGAYLSQRQELISEV-TEEGLALGQESTATVTPHTLQVAP 492
            QDG     S   E A  T+ +       Q L SE+ T + LA   E+   V P  + +AP
Sbjct: 1396 QDGAAPATSTMPEPASGTASQAGGPGTPQGLTSELETSQPLAETHEAPLAVQPLVVGLAP 1455

Query: 493  GLQV-EVATRVTPQAGEEETDSTAGQESAAMAMPQPSQEGISEIL----GQESVTAEKLP 547
                 E A+     A  E     A + S     PQP+    + +L    G  S+   +LP
Sbjct: 1456 CTPAPEAASTRDASAPREPLPPPAPEPSPHSGTPQPALGQPAPLLPAAVGAVSLATSQLP 1515

Query: 548  TPQEETSLTLCPDSPQNLKEEGGLDLPSGRKPVAAATIVPRQAKEDLTLPQD----SAMT 603
            +P      T+ P  P  L+ +G  + P  R     +TI     K    L Q+    S+ +
Sbjct: 1516 SPP--LGPTVPPQPPSALESDG--EGPPPRVGFVDSTIKSLDEKLRTLLYQEHVPTSSAS 1571

Query: 604  PPLPLQDTDLSSAPKPVAAATIVSQQAEEGLTLPQDSVMTPPLPLQDTE-LSSAPKPVAA 662
               P++  D     +P+      S+     L LP       P+P +        P+P+  
Sbjct: 1572 AGTPVEVGDRDFTLEPLRGDQPRSEVCGGDLALP-------PVPKEAVSGRVQLPQPLVE 1624

Query: 663  ATLVSQQAEEGLTLPQDSAMTPPLPLQDTDLSSAPKPVAA----ATLVSQQAEEGLTLPQ 718
             + ++      +     S+MT           S+P+ +         V+  +    ++PQ
Sbjct: 1625 KSELAPTRGAVMEQGTSSSMTA---------ESSPRSMLGYDRDGRQVASDSHVVPSVPQ 1675

Query: 719  D-SAMTPPLPLQDTDL-------SSAPKPVAAATLVSQQAEEGLTLPQDSAMTPPLPLQD 770
            D  A   P  ++ TD        SSA  P +    V  QA    TL   +  +P    + 
Sbjct: 1676 DVPAFVRPARVEPTDRDGGEAGESSAEPPPSDMGTVGGQASHPQTLGARALGSPRKRPEQ 1735

Query: 771  TDLSSAPKPVAAATIVSQQAEEGLTLPQDSAMTPPLPLQDTDLSSAP 817
             D+SS  K V   ++VS Q E  L  P     + P    D  L  AP
Sbjct: 1736 QDVSSPAKTVGRFSVVSTQDEWTLASPHSLRYSAP---PDVYLDEAP 1779



 Score = 39.3 bits (90), Expect = 0.030
 Identities = 42/139 (30%), Positives = 55/139 (39%), Gaps = 10/139 (7%)

Query: 951  EAGCAPGTEPVATMAQQEVGEALGPRPAPEEKNAALPTVPEPAALDQVQQDDPQPAAEAG 1010
            EA  APG +P   + Q+ V      R    E+    P  P PAAL   Q   P   A+AG
Sbjct: 58   EAAEAPGPQPPQPL-QRRVLLLCKTRRLIAERARGRPAAPAPAAL-VAQPGAPGAPADAG 115

Query: 1011 -TPWAAQEDADSTLGMEALSLPEPASGAGEEIAEALSRPGREACLEARAHTGDGAKPDSP 1069
              P   QE     +     + P P  G  EE A A  R   E   EA+       +P   
Sbjct: 116  PEPVGTQEPGPDPIAAAVETAPAPDGGPREE-AAATVRKEDEGAAEAK------PEPGRT 168

Query: 1070 QKETLEVENQQEGGLKPLA 1088
            +++  E E   E  LK +A
Sbjct: 169  RRDEPEEEEDDEDDLKAVA 187



 Score = 34.3 bits (77), Expect = 0.97
 Identities = 44/174 (25%), Positives = 63/174 (36%), Gaps = 18/174 (10%)

Query: 53  ALTFLPS-KPGARPQPEGASWDAGPGGAPSAWADPGEGGPSPMLLPEGLSSQALSTEAPL 111
           A++F P   P + P P G    A PG  P   A P         LP+ L+ Q +    P+
Sbjct: 703 AMSFAPVLPPPSTPMPTGPGQPAPPGQQPPPLAQPTP-------LPQVLAPQPVVPLQPV 755

Query: 112 PATLEPRIVMGEET-----CQALLSPRAARTALRDQEGGHASPDP--PPELCSQGDLSVP 164
           P  L P +    +       + L  P+A    L  Q      P P  PP     G   +P
Sbjct: 756 PPHLPPYLAPASQVGAPAQLKPLQMPQAPLQPLA-QVPPQMPPIPVVPPITPLAGIDGLP 814

Query: 165 SPPPDPDSFFTPPSTPTK--TTYALLPACGPHGDARDSEAELRDELLDSPPASP 216
              PD  +   PP  P +  +   +LP+             L+   L  PP +P
Sbjct: 815 PALPDLPTATVPPVPPPQYFSPAVILPSLAAPLPPASPALPLQAVKLPHPPGAP 868



 Score = 31.6 bits (70), Expect = 6.3
 Identities = 37/133 (27%), Positives = 47/133 (35%), Gaps = 34/133 (25%)

Query: 1173 PTSAPTSQQPEPVLGLGSVEQPHEVPSVLGT---PLLQPPENL----------------- 1212
            P +      P+  L    VE   E P  L     P  QPP+ L                 
Sbjct: 29   PRAKAARPGPQRFLRRSVVESDQEEPPGLEAAEAPGPQPPQPLQRRVLLLCKTRRLIAER 88

Query: 1213 AKGQPSTPVDRPLGPDPSAPGTLAGAALPPL--EPPAPCLCQDPQEDSVEDEEPPGSLGL 1270
            A+G+P+ P    L   P APG  A A   P+  + P P    DP   +VE          
Sbjct: 89   ARGRPAAPAPAALVAQPGAPGAPADAGPEPVGTQEPGP----DPIAAAVET--------A 136

Query: 1271 PPPQAGVQPAAAA 1283
            P P  G +  AAA
Sbjct: 137  PAPDGGPREEAAA 149


>gi|207113164 Treacher Collins-Franceschetti syndrome 1 isoform f
            [Homo sapiens]
          Length = 1412

 Score = 79.0 bits (193), Expect = 3e-14
 Identities = 197/952 (20%), Positives = 337/952 (35%), Gaps = 141/952 (14%)

Query: 510  ETDSTAGQESAAMAMPQPSQEGISEILGQESVTAEKLPTPQEETSLTLCPDSPQNLKEEG 569
            E D+    +   ++ P  + E   E    E+ TA+  P      S  L  D P ++KE+ 
Sbjct: 66   EEDAALQAKKTRVSDPISTSESSEEEEEAEAETAKATPRLASTNSSVLGADLPSSMKEKA 125

Query: 570  GLDLPSGRKPVAAATIVPRQAKEDLTLPQDSAMTPPLPLQDTDLSSAPKPVAAATIVSQQ 629
              +     K       +P  A         S  +P           + +P A  T+VS+ 
Sbjct: 126  KAETEKAGK---TGNSMPHPATGKTVANLLSGKSP---------RKSAEPSANTTLVSET 173

Query: 630  AEEGLTLPQDSVMTPPLPLQDTELSSAPKPVAAAT----LVSQQAEEGLTLPQDSAMTPP 685
             EEG ++P       P  +   +  S+ +  ++++    +  + +E+ L +   SA    
Sbjct: 174  EEEG-SVPAFGAAAKPGMVSAGQADSSSEDTSSSSDETDVEVKASEKILQVRAASAPAKG 232

Query: 686  LPLQDTDLSSAPKPVAAATLVSQQAEEGLTLPQDSAMTPPLPLQDTDLSSAPKPVAAATL 745
             P       + P P   A  V+ Q + G   P++ + +        + S + +   AA  
Sbjct: 233  TP----GKGATPAPPGKAGAVASQTKAG--KPEEDSES-----SSEESSDSEEETPAAKA 281

Query: 746  VSQQAEEGLTLPQDSAMTPPLPLQDTDLSSAPK----PVAAATIVSQQAEEGLTLPQDSA 801
            + Q    G T    +A  P         + AP     P  A     ++ E+  +  ++S 
Sbjct: 282  LLQAKASGKTSQVGAASAPAKESPRKGAAPAPPGKTGPAVAKAQAGKREEDSQSSSEESD 341

Query: 802  MTPPLPLQDTDLSSAPKPVAAATIVSQQAEEGLTLPQDSAMTPPLPLQDTDLSSAPKPVA 861
                 P Q      AP+  AA+    +   +G           P P + T       P A
Sbjct: 342  SEEEAPAQAKPSGKAPQVRAASAPAKESPRKG---------AAPAPPRKTG------PAA 386

Query: 862  AATPVSQQAEEGLTLPQDSAMTPPLPLQDTDLSS-APKPVAAATPVSQQAEEGLTLPQDS 920
            A   V +Q E+  +  ++S         D+D  + A    A   P+ +  +     P  +
Sbjct: 387  AQVQVGKQEEDSRSSSEES---------DSDREALAAMNAAQVKPLGKSPQ---VKPAST 434

Query: 921  AMTAPLPLQDTGPTSGPEPLAVATPQTLQAEAG---------------CAPGTEPVATMA 965
                PL     G  +GP P     P T  A+ G                + G  P A   
Sbjct: 435  MGMGPL-----GKGAGPVPPGKVGPATPSAQVGKWEEDSESSSEESSDSSDGEVPTAVAP 489

Query: 966  QQE--VGEALGPRPAPEEKNAALPTVPEPAALDQVQQDDPQPAAEAGTPWAAQEDADSTL 1023
             QE  +G  L  +P         P    P A+ QV+ + P   +E     +++E +DS  
Sbjct: 490  AQEKSLGNILQAKPTSSPAKGP-PQKAGPVAV-QVKAEKPMDNSE-----SSEESSDSAD 542

Query: 1024 GMEALSLPEPASGAGEEIAEALSRPGREACLEARAHTGDGAKPDSPQKETLEVENQQEGG 1083
              EA     PA+    +   AL  P  +AC   + +T   AK  +P +   +   +    
Sbjct: 543  SEEA-----PAAMTAAQAKPALKIPQTKAC-PKKTNTTASAKV-APVRVGTQAPRKAGTA 595

Query: 1084 LKPLAQEHGPRSALGGAREVPDAPPAACPEVSQARLLSPAREERGLSGKSTPEPTLPSAV 1143
              P     G   A+ G  + P A  ++  E S +       E+ GL+       ++   +
Sbjct: 596  TSPA----GSSPAVAGGTQRP-AEDSSSSEESDSE-----EEKTGLAVTVGQAKSVGKGL 645

Query: 1144 ATEASLDSCPESSVGAVSSLDRG-CPDAPAPTSAPTSQ-QPEPVLGLGSVEQPHEVPSVL 1201
              +A       +SV    SL +G  P  P  T    +Q + E      S E+  +     
Sbjct: 646  QVKA-------ASVPVKGSLGQGTAPVLPGKTGPTVTQVKAEKQEDSESSEEESDSEEAA 698

Query: 1202 GTPL---LQPPENLAKGQPSTPVDRPLGPDPSAPGTLAGAAL-------PPLEPPAPCLC 1251
             +P        +  AK  P+           SAPG +  AA          ++PP     
Sbjct: 699  ASPAQVKTSVKKTQAKANPAAARAPSAKGTISAPGKVVTAAAQAKQRSPSKVKPPV---- 754

Query: 1252 QDPQEDSVEDEEPPGSLGLPPPQAGVQPAAAAVSGTTQPLGTGPRVSLS-PHSPLLSPKV 1310
            ++PQ  +V      G   +P     V  AA A +G  +  G+    S S   +  L+   
Sbjct: 755  RNPQNSTVLAR---GPASVPSVGKAVATAAQAQTGPEEDSGSSEEESDSEEEAETLAQVK 811

Query: 1311 ASMDAKDLALQILPPCQVPPPSGPQSPAGPQGLSAPEQQEDEDSLEEDSPRALGSGQHSD 1370
             S     +   + P  + P      +P G  G SA +  + +DS          S + SD
Sbjct: 812  PSGKTHQIRAALAPAKESPRKGAAPTPPGKTGPSAAQAGKQDDS--------GSSSEESD 863

Query: 1371 SHGESSAELDEQDILAPQTVQCPAQAPAGGSEETIAKAKQSRSEKKARKAMS 1422
            S GE+ A +    ++ P  +         G   T A+A+ + + +KAR + S
Sbjct: 864  SDGEAPAAVTSAQVIKPPLIFVDPNRSPAGPAATPAQAQAASTPRKARASES 915



 Score = 65.1 bits (157), Expect = 5e-10
 Identities = 226/1050 (21%), Positives = 365/1050 (34%), Gaps = 210/1050 (20%)

Query: 406  SGEPHAQATLLQDSVQKTEEESGGGAKGLQAQDGTVSWAVEAAPQTSDRGAYLSQRQELI 465
            S EP A  TL    V +TEEE    A G  A+ G VS     A  +S+  +  S   ++ 
Sbjct: 160  SAEPSANTTL----VSETEEEGSVPAFGAAAKPGMVS--AGQADSSSEDTSSSSDETDVE 213

Query: 466  SEVTEEGLALGQEST-ATVTPH--TLQVAPGLQVEVATRVTPQAGEEETDSTAGQES--- 519
             + +E+ L +   S  A  TP        PG    VA++      EE+++S++ + S   
Sbjct: 214  VKASEKILQVRAASAPAKGTPGKGATPAPPGKAGAVASQTKAGKPEEDSESSSEESSDSE 273

Query: 520  ----AAMAMPQPSQEGISEILGQESVTAEK------LPTPQEETSLTLCPDSPQNLKEEG 569
                AA A+ Q    G +  +G  S  A++       P P  +T   +        +E  
Sbjct: 274  EETPAAKALLQAKASGKTSQVGAASAPAKESPRKGAAPAPPGKTGPAVAKAQAGKREE-- 331

Query: 570  GLDLPSGRKPVAAATIVPRQAKEDLTLPQDSAMTPPLPLQDTDLSSAPKP------VAAA 623
              D  S  +   +    P QAK     PQ  A + P   +     +AP P       AA 
Sbjct: 332  --DSQSSSEESDSEEEAPAQAKPSGKAPQVRAASAPAK-ESPRKGAAPAPPRKTGPAAAQ 388

Query: 624  TIVSQQAEEGLTLPQDS-----VMTPPLPLQDTELSSAPKPVAAATLVSQQAEEGLTLPQ 678
              V +Q E+  +  ++S      +      Q   L  +P+   A+T+      +G     
Sbjct: 389  VQVGKQEEDSRSSSEESDSDREALAAMNAAQVKPLGKSPQVKPASTMGMGPLGKGAGPVP 448

Query: 679  DSAMTPPLPL---------------QDTDLSSAPKPVAAATLVSQQAEEGLTLPQDS--A 721
               + P  P                + +D S    P A A    +     L     S  A
Sbjct: 449  PGKVGPATPSAQVGKWEEDSESSSEESSDSSDGEVPTAVAPAQEKSLGNILQAKPTSSPA 508

Query: 722  MTPPL-------------PLQDTDLS-----SAPKPVAAATLVSQQAEEGLTLPQDSAMT 763
              PP              P+ +++ S     SA    A A + + QA+  L +PQ  A  
Sbjct: 509  KGPPQKAGPVAVQVKAEKPMDNSESSEESSDSADSEEAPAAMTAAQAKPALKIPQTKACP 568

Query: 764  PPLPLQDTDLSSAPKPVAAATIVSQQAEEGLTLPQDSAMTPPL------PLQDTDLS--- 814
                 + T+ +++ K VA   + +Q   +  T    +  +P +      P +D+  S   
Sbjct: 569  -----KKTNTTASAK-VAPVRVGTQAPRKAGTATSPAGSSPAVAGGTQRPAEDSSSSEES 622

Query: 815  -SAPKPVAAATIVSQQAEEGLTLPQDSAMTPP-----------LP--------------L 848
             S  +    A  V Q    G  L   +A  P            LP               
Sbjct: 623  DSEEEKTGLAVTVGQAKSVGKGLQVKAASVPVKGSLGQGTAPVLPGKTGPTVTQVKAEKQ 682

Query: 849  QDTDLSS--APKPVAAATPVSQQAEEGLTLPQDSAMTPPLPLQDTDLSSAPKPVAAATPV 906
            +D++ S   +    AAA+P   +     T  + +      P     +S+  K V AA   
Sbjct: 683  EDSESSEEESDSEEAAASPAQVKTSVKKTQAKANPAAARAPSAKGTISAPGKVVTAAAQA 742

Query: 907  SQQA----EEGLTLPQDSAMTAPLPLQDTGPTSGPEPLAVATPQTLQAEAGC-------- 954
             Q++    +  +  PQ+S + A       GP S P  +  A     QA+ G         
Sbjct: 743  KQRSPSKVKPPVRNPQNSTVLA------RGPASVPS-VGKAVATAAQAQTGPEEDSGSSE 795

Query: 955  --APGTEPVATMAQ-------QEVGEALGPRPAPEEKNAALPTVPE---PAALDQVQQDD 1002
              +   E   T+AQ        ++  AL P      K AA PT P    P+A    +QDD
Sbjct: 796  EESDSEEEAETLAQVKPSGKTHQIRAALAPAKESPRKGAA-PTPPGKTGPSAAQAGKQDD 854

Query: 1003 PQPAAEAGTPWAAQEDADSTLGMEALSLPEPA--------SGAGEEI----AEALSRPGR 1050
               ++E      +  D ++   + +  + +P         S AG       A+A S P +
Sbjct: 855  SGSSSEE-----SDSDGEAPAAVTSAQVIKPPLIFVDPNRSPAGPAATPAQAQAASTPRK 909

Query: 1051 EACLEARAHTGDGAKPDSPQKETLEVENQQEGGLKPLAQEHGPRSALGGAREVPDAPPAA 1110
                E+ A +      +S  ++ +        G++                 +P A P  
Sbjct: 910  ARASESTARSSSS---ESEDEDVIPATQCLTPGIRT------------NVVTMPTAHPRI 954

Query: 1111 CPEVSQARLLSPAREERGLSGKSTPEP----------TLP------SAVATEASLDSCPE 1154
             P+ S A   S     R   GK    P          +LP        +A +AS    P 
Sbjct: 955  APKASMAGASSSKESSRISDGKKQEGPATQVSKKNPASLPLTQAALKVLAQKASEAQPPV 1014

Query: 1155 SSVGAVSSLDRGCPDAPAPTSAPTSQQPEPVLGLGSVEQPHEVPSVLGTPLLQPPENLAK 1214
            +     S +D      PA +   TS Q +   G   + +P ++P V      + PE+   
Sbjct: 1015 ARTQPSSGVDSAVGTLPATSPQSTSVQAK---GTNKLRKP-KLPEV--QQATKAPESSDD 1068

Query: 1215 GQPSTPVDRPLGPDPSAPGTLAGAALPPLEPPAP----CLCQDPQEDSVEDE--EPPGSL 1268
             + S+  D   G +    G     +   L  P P     L ++   +S ED+   P  SL
Sbjct: 1069 SEDSS--DSSSGSEEDGEGPQGAKSAHTLVGPTPSRTETLVEETAAESSEDDVVAPSQSL 1126

Query: 1269 GLPPPQAGVQPAAAAVSGTTQPLGTGPRVS 1298
                   G+ PA +  S  T  L + P VS
Sbjct: 1127 LSGYMTPGLTPANSQASKATPKLDSSPSVS 1156



 Score = 59.7 bits (143), Expect = 2e-08
 Identities = 165/765 (21%), Positives = 271/765 (35%), Gaps = 134/765 (17%)

Query: 809  QDTDLSSAPKPVAAATIVSQQAEEGLTLPQDSAM-TPPLPLQDTDLSSAPKPVAAATPVS 867
            +D  L +    V+     S+ +EE      ++A  TP L   ++ +  A  P +      
Sbjct: 67   EDAALQAKKTRVSDPISTSESSEEEEEAEAETAKATPRLASTNSSVLGADLPSSMKEKAK 126

Query: 868  QQAEE----GLTLPQDSA-MTPPLPLQDTDLSSAPKPVAAATPVSQQAEEGLTLPQDSAM 922
             + E+    G ++P  +   T    L       + +P A  T VS+  EEG ++P   A 
Sbjct: 127  AETEKAGKTGNSMPHPATGKTVANLLSGKSPRKSAEPSANTTLVSETEEEG-SVPAFGAA 185

Query: 923  TAPLPL---------QDTGPTSGPEPLAV-ATPQTLQAEAGCAPGTEPVATMAQQEVGEA 972
              P  +         +DT  +S    + V A+ + LQ  A  AP        A+   G+ 
Sbjct: 186  AKPGMVSAGQADSSSEDTSSSSDETDVEVKASEKILQVRAASAP--------AKGTPGK- 236

Query: 973  LGPRPAPEEKNAALPTVPEPAALDQVQQDDPQPAAEAGTPWAAQEDADSTLGMEALSLPE 1032
             G  PAP  K  A+ +        Q +   P+  +E+ +  ++  + + T   +AL L  
Sbjct: 237  -GATPAPPGKAGAVAS--------QTKAGKPEEDSESSSEESSDSE-EETPAAKAL-LQA 285

Query: 1033 PASGAGEEIAEALSRPGREACLEARAHTGDGAKPDSPQKETLEVENQQEGGLKPLAQEHG 1092
             ASG   ++  A S P +E+  +       GA P  P K    V   Q G  +  +Q   
Sbjct: 286  KASGKTSQVGAA-SAPAKESPRK-------GAAPAPPGKTGPAVAKAQAGKREEDSQSSS 337

Query: 1093 PRSALGGAREVPDAPPAACPEVSQARLLSPAREE-RGLSGKSTPEPTLPSAVATEASLDS 1151
              S           P    P+V  A   +PA+E  R  +  + P  T P+A   +     
Sbjct: 338  EESDSEEEAPAQAKPSGKAPQVRAAS--APAKESPRKGAAPAPPRKTGPAAAQVQVGKQE 395

Query: 1152 CPESSVGAVSSLDRGCPDAPAPTSAPTSQQPEPVLGLGSVEQPHEVPSVLGTPLLQPPEN 1211
                S    S  DR         +A  + Q +P   LG             +P ++P   
Sbjct: 396  EDSRSSSEESDSDREA------LAAMNAAQVKP---LGK------------SPQVKPAST 434

Query: 1212 LAKGQPSTPVDRPLGPDPSAPGTLAGAALPPLEPPAPCLCQDPQEDSVEDEEPPGSLGLP 1271
            +  G    P+ +  GP P  PG +      P  P A     +   +S  +E    S G  
Sbjct: 435  MGMG----PLGKGAGPVP--PGKVG-----PATPSAQVGKWEEDSESSSEESSDSSDGEV 483

Query: 1272 PPQAGVQPAAAAVSGTTQPLGTGPRVSLSPHSPLLSPKVASMDAKDLALQILPPCQVPPP 1331
            P    V PA     G                  +L  K  S  AK               
Sbjct: 484  P--TAVAPAQEKSLGN-----------------ILQAKPTSSPAK--------------- 509

Query: 1332 SGPQSPAGPQGLSAPEQQEDEDSLEEDSPRALGSGQHSDSHGESSAELDEQDILAPQTVQ 1391
             GP   AGP  +    ++  ++S  E S  +  S    ++    +A   +  +  PQT  
Sbjct: 510  -GPPQKAGPVAVQVKAEKPMDNS--ESSEESSDSADSEEAPAAMTAAQAKPALKIPQTKA 566

Query: 1392 CPAQAPAGGSEETIAKAKQSRSEKKARKAMSKLGLR-QIQGVTRITIQKSKNILFVIAKP 1450
            CP +     S +       +++ +KA  A S  G    + G T+   + S +     ++ 
Sbjct: 567  CPKKTNTTASAKVAPVRVGTQAPRKAGTATSPAGSSPAVAGGTQRPAEDSSS-----SEE 621

Query: 1451 DVFKSPASDTYVVFGEAKIEDLSQQVHKAAAEKFK----------VPSEPSALVPESAPR 1500
               +   +   V  G+AK      QV KAA+   K          +P +    V +    
Sbjct: 622  SDSEEEKTGLAVTVGQAKSVGKGLQV-KAASVPVKGSLGQGTAPVLPGKTGPTVTQVKAE 680

Query: 1501 PRVRLECKEEEEEEEEEVDEAGLELRDIELVMAQANVSRAKAVRA 1545
             +   E  EEE + EE           ++   A+AN + A+A  A
Sbjct: 681  KQEDSESSEEESDSEEAAASPAQVKTSVKKTQAKANPAAARAPSA 725



 Score = 56.2 bits (134), Expect = 2e-07
 Identities = 167/805 (20%), Positives = 269/805 (33%), Gaps = 110/805 (13%)

Query: 328  PLSPEEEEEEAVADPDPGGDLAGEGEEDSTSASFLQSLSDL----SITEGMDEAFAFRDD 383
            P       EE+ ++ +  G     G+  S         + +    S+ +G       +  
Sbjct: 612  PAEDSSSSEESDSEEEKTGLAVTVGQAKSVGKGLQVKAASVPVKGSLGQGTAPVLPGKTG 671

Query: 384  TSAASSDSDSASYAEADDERLYSGEPHAQATLLQDSVQKTEEESGGGAKGLQAQDGTVS- 442
             +     ++    +E+ +E   S E  A    ++ SV+KT+ ++   A    +  GT+S 
Sbjct: 672  PTVTQVKAEKQEDSESSEEESDSEEAAASPAQVKTSVKKTQAKANPAAARAPSAKGTISA 731

Query: 443  --WAVEAAPQTSDRGAYLSQRQELISEVTEEGLALGQESTATVTPHTLQVAPGLQVEVAT 500
                V AA Q   R      +  + +      LA G  S  +V      VA   Q +   
Sbjct: 732  PGKVVTAAAQAKQRSP-SKVKPPVRNPQNSTVLARGPASVPSVGK---AVATAAQAQTGP 787

Query: 501  RVTPQAGEEETDSTAGQESAAMAMPQPSQEGISEIL--GQESVTAEKLPTPQEETSLTLC 558
                 + EEE+DS    E+ A   P      I   L   +ES      PTP  +T  +  
Sbjct: 788  EEDSGSSEEESDSEEEAETLAQVKPSGKTHQIRAALAPAKESPRKGAAPTPPGKTGPSAA 847

Query: 559  ----PDSPQNLKEEGGLDLPSGRKPVAAATIVPRQAKEDLTLPQDSAMTPPLPLQDTDLS 614
                 D   +  EE   D  +     +A  I P     D   P  S   P         +
Sbjct: 848  QAGKQDDSGSSSEESDSDGEAPAAVTSAQVIKPPLIFVD---PNRSPAGPAATPAQAQAA 904

Query: 615  SAPKPVAA----ATIVSQQAEEGLTLPQDSVMTPPLPLQDTELSSAPKPVAAATLVSQQA 670
            S P+   A    A   S ++E+   +P    +TP +      + +A   +A         
Sbjct: 905  STPRKARASESTARSSSSESEDEDVIPATQCLTPGIRTNVVTMPTAHPRIA--------- 955

Query: 671  EEGLTLPQDSAMTPPLPLQDTDLSSAPKPVAAATLVSQQAEEGLTLPQDSAMTPPLPLQD 730
                  P+ S        + + +S   K    AT VS++    L L Q +     L +  
Sbjct: 956  ------PKASMAGASSSKESSRISDGKKQEGPATQVSKKNPASLPLTQAA-----LKVLA 1004

Query: 731  TDLSSAPKPVAAATLVSQQAEEGLTLPQDSAMTPPLPLQDTDLSSAPK--PVAAATIVSQ 788
               S A  PVA     S       TLP  S  +  +  + T+    PK   V  AT   +
Sbjct: 1005 QKASEAQPPVARTQPSSGVDSAVGTLPATSPQSTSVQAKGTNKLRKPKLPEVQQATKAPE 1064

Query: 789  QAEEGLTLPQDSAMTP-----PLPLQDTDLSSAPKPVAAATIVSQQAEEGLTLPQDSAMT 843
             +++       S+ +      P   +       P P    T+V + A E     +D  + 
Sbjct: 1065 SSDDSEDSSDSSSGSEEDGEGPQGAKSAHTLVGPTPSRTETLVEETAAES---SEDDVVA 1121

Query: 844  PPLPLQDTDLSSAPKPVAAATPVSQQAEEGLTLPQDSAMTPPLPLQDTDLSSAPKPVAAA 903
            P   L    LS    P    TP + QA         S  TP L   D+  S +    A  
Sbjct: 1122 PSQSL----LSGYMTP--GLTPANSQA---------SKATPKL---DSSPSVSSTLAAKD 1163

Query: 904  TPVSQQAEEGLTLPQDSA-MTAPLPLQDTGPTSGPEPLAVATPQTLQAEAGCAPGTEPVA 962
             P  +Q  +    PQ +A M +P        T G E  +  TPQ  +     A   +   
Sbjct: 1164 DPDGKQEAK----PQQAAGMLSP-------KTGGKEAASGTTPQKSRKPKKGAGNPQAST 1212

Query: 963  TMAQQEVGEALGPRPAP-------------------EEKNAALPTVPEPAALD----QVQ 999
               Q  + + L  +P P                   +E+   + T  E +       + +
Sbjct: 1213 LALQSNITQCLLGQPWPLNEAQVQASVVKVLTELLEQERKKVVDTTKESSRKGWESRKRK 1272

Query: 1000 QDDPQPAAEAGTPWA-AQEDADSTLGMEALSLPEPASGAGEEIAEALSRPGREACLEARA 1058
                QPAA   TP +  ++   +  G EA   PE  S   +  A+     G     + + 
Sbjct: 1273 LSGDQPAAR--TPRSKKKKKLGAGEGGEASVSPEKTSTTSKGKAKRDKASGDVKEKKGKG 1330

Query: 1059 HTGDGAKPDSPQKETLEVENQQEGG 1083
              G     D P++E  +     EGG
Sbjct: 1331 SLGSQGAKDEPEEELQKGMGTVEGG 1355


>gi|57164975 Treacher Collins-Franceschetti syndrome 1 isoform b [Homo
            sapiens]
          Length = 1411

 Score = 79.0 bits (193), Expect = 3e-14
 Identities = 197/952 (20%), Positives = 337/952 (35%), Gaps = 141/952 (14%)

Query: 510  ETDSTAGQESAAMAMPQPSQEGISEILGQESVTAEKLPTPQEETSLTLCPDSPQNLKEEG 569
            E D+    +   ++ P  + E   E    E+ TA+  P      S  L  D P ++KE+ 
Sbjct: 66   EEDAALQAKKTRVSDPISTSESSEEEEEAEAETAKATPRLASTNSSVLGADLPSSMKEKA 125

Query: 570  GLDLPSGRKPVAAATIVPRQAKEDLTLPQDSAMTPPLPLQDTDLSSAPKPVAAATIVSQQ 629
              +     K       +P  A         S  +P           + +P A  T+VS+ 
Sbjct: 126  KAETEKAGK---TGNSMPHPATGKTVANLLSGKSP---------RKSAEPSANTTLVSET 173

Query: 630  AEEGLTLPQDSVMTPPLPLQDTELSSAPKPVAAAT----LVSQQAEEGLTLPQDSAMTPP 685
             EEG ++P       P  +   +  S+ +  ++++    +  + +E+ L +   SA    
Sbjct: 174  EEEG-SVPAFGAAAKPGMVSAGQADSSSEDTSSSSDETDVEVKASEKILQVRAASAPAKG 232

Query: 686  LPLQDTDLSSAPKPVAAATLVSQQAEEGLTLPQDSAMTPPLPLQDTDLSSAPKPVAAATL 745
             P       + P P   A  V+ Q + G   P++ + +        + S + +   AA  
Sbjct: 233  TP----GKGATPAPPGKAGAVASQTKAG--KPEEDSES-----SSEESSDSEEETPAAKA 281

Query: 746  VSQQAEEGLTLPQDSAMTPPLPLQDTDLSSAPK----PVAAATIVSQQAEEGLTLPQDSA 801
            + Q    G T    +A  P         + AP     P  A     ++ E+  +  ++S 
Sbjct: 282  LLQAKASGKTSQVGAASAPAKESPRKGAAPAPPGKTGPAVAKAQAGKREEDSQSSSEESD 341

Query: 802  MTPPLPLQDTDLSSAPKPVAAATIVSQQAEEGLTLPQDSAMTPPLPLQDTDLSSAPKPVA 861
                 P Q      AP+  AA+    +   +G           P P + T       P A
Sbjct: 342  SEEEAPAQAKPSGKAPQVRAASAPAKESPRKG---------AAPAPPRKTG------PAA 386

Query: 862  AATPVSQQAEEGLTLPQDSAMTPPLPLQDTDLSS-APKPVAAATPVSQQAEEGLTLPQDS 920
            A   V +Q E+  +  ++S         D+D  + A    A   P+ +  +     P  +
Sbjct: 387  AQVQVGKQEEDSRSSSEES---------DSDREALAAMNAAQVKPLGKSPQ---VKPAST 434

Query: 921  AMTAPLPLQDTGPTSGPEPLAVATPQTLQAEAG---------------CAPGTEPVATMA 965
                PL     G  +GP P     P T  A+ G                + G  P A   
Sbjct: 435  MGMGPL-----GKGAGPVPPGKVGPATPSAQVGKWEEDSESSSEESSDSSDGEVPTAVAP 489

Query: 966  QQE--VGEALGPRPAPEEKNAALPTVPEPAALDQVQQDDPQPAAEAGTPWAAQEDADSTL 1023
             QE  +G  L  +P         P    P A+ QV+ + P   +E     +++E +DS  
Sbjct: 490  AQEKSLGNILQAKPTSSPAKGP-PQKAGPVAV-QVKAEKPMDNSE-----SSEESSDSAD 542

Query: 1024 GMEALSLPEPASGAGEEIAEALSRPGREACLEARAHTGDGAKPDSPQKETLEVENQQEGG 1083
              EA     PA+    +   AL  P  +AC   + +T   AK  +P +   +   +    
Sbjct: 543  SEEA-----PAAMTAAQAKPALKIPQTKAC-PKKTNTTASAKV-APVRVGTQAPRKAGTA 595

Query: 1084 LKPLAQEHGPRSALGGAREVPDAPPAACPEVSQARLLSPAREERGLSGKSTPEPTLPSAV 1143
              P     G   A+ G  + P A  ++  E S +       E+ GL+       ++   +
Sbjct: 596  TSPA----GSSPAVAGGTQRP-AEDSSSSEESDSE-----EEKTGLAVTVGQAKSVGKGL 645

Query: 1144 ATEASLDSCPESSVGAVSSLDRG-CPDAPAPTSAPTSQ-QPEPVLGLGSVEQPHEVPSVL 1201
              +A       +SV    SL +G  P  P  T    +Q + E      S E+  +     
Sbjct: 646  QVKA-------ASVPVKGSLGQGTAPVLPGKTGPTVTQVKAEKQEDSESSEEESDSEEAA 698

Query: 1202 GTPL---LQPPENLAKGQPSTPVDRPLGPDPSAPGTLAGAAL-------PPLEPPAPCLC 1251
             +P        +  AK  P+           SAPG +  AA          ++PP     
Sbjct: 699  ASPAQVKTSVKKTQAKANPAAARAPSAKGTISAPGKVVTAAAQAKQRSPSKVKPPV---- 754

Query: 1252 QDPQEDSVEDEEPPGSLGLPPPQAGVQPAAAAVSGTTQPLGTGPRVSLS-PHSPLLSPKV 1310
            ++PQ  +V      G   +P     V  AA A +G  +  G+    S S   +  L+   
Sbjct: 755  RNPQNSTVLAR---GPASVPSVGKAVATAAQAQTGPEEDSGSSEEESDSEEEAETLAQVK 811

Query: 1311 ASMDAKDLALQILPPCQVPPPSGPQSPAGPQGLSAPEQQEDEDSLEEDSPRALGSGQHSD 1370
             S     +   + P  + P      +P G  G SA +  + +DS          S + SD
Sbjct: 812  PSGKTHQIRAALAPAKESPRKGAAPTPPGKTGPSAAQAGKQDDS--------GSSSEESD 863

Query: 1371 SHGESSAELDEQDILAPQTVQCPAQAPAGGSEETIAKAKQSRSEKKARKAMS 1422
            S GE+ A +    ++ P  +         G   T A+A+ + + +KAR + S
Sbjct: 864  SDGEAPAAVTSAQVIKPPLIFVDPNRSPAGPAATPAQAQAASTPRKARASES 915



 Score = 65.9 bits (159), Expect = 3e-10
 Identities = 225/1047 (21%), Positives = 363/1047 (34%), Gaps = 205/1047 (19%)

Query: 406  SGEPHAQATLLQDSVQKTEEESGGGAKGLQAQDGTVSWAVEAAPQTSDRGAYLSQRQELI 465
            S EP A  TL    V +TEEE    A G  A+ G VS     A  +S+  +  S   ++ 
Sbjct: 160  SAEPSANTTL----VSETEEEGSVPAFGAAAKPGMVS--AGQADSSSEDTSSSSDETDVE 213

Query: 466  SEVTEEGLALGQEST-ATVTPH--TLQVAPGLQVEVATRVTPQAGEEETDSTAGQES--- 519
             + +E+ L +   S  A  TP        PG    VA++      EE+++S++ + S   
Sbjct: 214  VKASEKILQVRAASAPAKGTPGKGATPAPPGKAGAVASQTKAGKPEEDSESSSEESSDSE 273

Query: 520  ----AAMAMPQPSQEGISEILGQESVTAEK------LPTPQEETSLTLCPDSPQNLKEEG 569
                AA A+ Q    G +  +G  S  A++       P P  +T   +        +E  
Sbjct: 274  EETPAAKALLQAKASGKTSQVGAASAPAKESPRKGAAPAPPGKTGPAVAKAQAGKREE-- 331

Query: 570  GLDLPSGRKPVAAATIVPRQAKEDLTLPQDSAMTPPLPLQDTDLSSAPKP------VAAA 623
              D  S  +   +    P QAK     PQ  A + P   +     +AP P       AA 
Sbjct: 332  --DSQSSSEESDSEEEAPAQAKPSGKAPQVRAASAPAK-ESPRKGAAPAPPRKTGPAAAQ 388

Query: 624  TIVSQQAEEGLTLPQDS-----VMTPPLPLQDTELSSAPKPVAAATLVSQQAEEGLTLPQ 678
              V +Q E+  +  ++S      +      Q   L  +P+   A+T+      +G     
Sbjct: 389  VQVGKQEEDSRSSSEESDSDREALAAMNAAQVKPLGKSPQVKPASTMGMGPLGKGAGPVP 448

Query: 679  DSAMTPPLPL---------------QDTDLSSAPKPVAAATLVSQQAEEGLTLPQDS--A 721
               + P  P                + +D S    P A A    +     L     S  A
Sbjct: 449  PGKVGPATPSAQVGKWEEDSESSSEESSDSSDGEVPTAVAPAQEKSLGNILQAKPTSSPA 508

Query: 722  MTPPL-------------PLQDTDLS-----SAPKPVAAATLVSQQAEEGLTLPQDSAMT 763
              PP              P+ +++ S     SA    A A + + QA+  L +PQ  A  
Sbjct: 509  KGPPQKAGPVAVQVKAEKPMDNSESSEESSDSADSEEAPAAMTAAQAKPALKIPQTKACP 568

Query: 764  PPLPLQDTDLSSAPKPVAAATIVSQQAEEGLTLPQDSAMTPPL------PLQDTDLS--- 814
                 + T+ +++ K VA   + +Q   +  T    +  +P +      P +D+  S   
Sbjct: 569  -----KKTNTTASAK-VAPVRVGTQAPRKAGTATSPAGSSPAVAGGTQRPAEDSSSSEES 622

Query: 815  -SAPKPVAAATIVSQQAEEGLTLPQDSAMTPP-----------LP--------------L 848
             S  +    A  V Q    G  L   +A  P            LP               
Sbjct: 623  DSEEEKTGLAVTVGQAKSVGKGLQVKAASVPVKGSLGQGTAPVLPGKTGPTVTQVKAEKQ 682

Query: 849  QDTDLSS--APKPVAAATPVSQQAEEGLTLPQDSAMTPPLPLQDTDLSSAPKPVAAATPV 906
            +D++ S   +    AAA+P   +     T  + +      P     +S+  K V AA   
Sbjct: 683  EDSESSEEESDSEEAAASPAQVKTSVKKTQAKANPAAARAPSAKGTISAPGKVVTAAAQA 742

Query: 907  SQQA----EEGLTLPQDSAMTAPLPLQDTGPTSGPEPLAVATPQTLQAEAGC-------- 954
             Q++    +  +  PQ+S + A       GP S P  +  A     QA+ G         
Sbjct: 743  KQRSPSKVKPPVRNPQNSTVLA------RGPASVPS-VGKAVATAAQAQTGPEEDSGSSE 795

Query: 955  --APGTEPVATMAQ-------QEVGEALGPRPAPEEKNAALPTVPE---PAALDQVQQDD 1002
              +   E   T+AQ        ++  AL P      K AA PT P    P+A    +QDD
Sbjct: 796  EESDSEEEAETLAQVKPSGKTHQIRAALAPAKESPRKGAA-PTPPGKTGPSAAQAGKQDD 854

Query: 1003 PQPAAEAGTPWAAQEDADSTLGMEALSLPEPA--------SGAGEEI----AEALSRPGR 1050
               ++E      +  D ++   + +  + +P         S AG       A+A S P +
Sbjct: 855  SGSSSEE-----SDSDGEAPAAVTSAQVIKPPLIFVDPNRSPAGPAATPAQAQAASTPRK 909

Query: 1051 EACLEARAHTGDGAKPDSPQKETLEVENQQEGGLKPLAQEHGPRSALGGAREVPDAPPAA 1110
                E+ A +      +S  ++ +        G++                 +P A P  
Sbjct: 910  ARASESTARSSSS---ESEDEDVIPATQCLTPGIRT------------NVVTMPTAHPRI 954

Query: 1111 CPEVSQARLLSPAREERGLSGKSTPEP----------TLP------SAVATEASLDSCPE 1154
             P+ S A   S     R   GK    P          +LP        +A +AS    P 
Sbjct: 955  APKASMAGASSSKESSRISDGKKQEGPATQVSKKNPASLPLTQAALKVLAQKASEAQPPV 1014

Query: 1155 SSVGAVSSLDRGCPDAPAPTSAPTSQQPEPVLGLGSVEQPHEVPSVLGTPLLQPPENLAK 1214
            +     S +D      PA +   TS Q +   G   + +P ++P V      + PE+   
Sbjct: 1015 ARTQPSSGVDSAVGTLPATSPQSTSVQAK---GTNKLRKP-KLPEV--QQATKAPESSDD 1068

Query: 1215 GQPSTPVDRPLGPDPSAP-GTLAGAALPPLEPPAPCLCQDPQEDSVEDE--EPPGSLGLP 1271
             + S+        D   P G  +   L P       L ++   +S ED+   P  SL   
Sbjct: 1069 SEDSSDSSSGSEEDGEGPQGAKSAHTLGPTPSRTETLVEETAAESSEDDVVAPSQSLLSG 1128

Query: 1272 PPQAGVQPAAAAVSGTTQPLGTGPRVS 1298
                G+ PA +  S  T  L + P VS
Sbjct: 1129 YMTPGLTPANSQASKATPKLDSSPSVS 1155



 Score = 59.7 bits (143), Expect = 2e-08
 Identities = 165/765 (21%), Positives = 271/765 (35%), Gaps = 134/765 (17%)

Query: 809  QDTDLSSAPKPVAAATIVSQQAEEGLTLPQDSAM-TPPLPLQDTDLSSAPKPVAAATPVS 867
            +D  L +    V+     S+ +EE      ++A  TP L   ++ +  A  P +      
Sbjct: 67   EDAALQAKKTRVSDPISTSESSEEEEEAEAETAKATPRLASTNSSVLGADLPSSMKEKAK 126

Query: 868  QQAEE----GLTLPQDSA-MTPPLPLQDTDLSSAPKPVAAATPVSQQAEEGLTLPQDSAM 922
             + E+    G ++P  +   T    L       + +P A  T VS+  EEG ++P   A 
Sbjct: 127  AETEKAGKTGNSMPHPATGKTVANLLSGKSPRKSAEPSANTTLVSETEEEG-SVPAFGAA 185

Query: 923  TAPLPL---------QDTGPTSGPEPLAV-ATPQTLQAEAGCAPGTEPVATMAQQEVGEA 972
              P  +         +DT  +S    + V A+ + LQ  A  AP        A+   G+ 
Sbjct: 186  AKPGMVSAGQADSSSEDTSSSSDETDVEVKASEKILQVRAASAP--------AKGTPGK- 236

Query: 973  LGPRPAPEEKNAALPTVPEPAALDQVQQDDPQPAAEAGTPWAAQEDADSTLGMEALSLPE 1032
             G  PAP  K  A+ +        Q +   P+  +E+ +  ++  + + T   +AL L  
Sbjct: 237  -GATPAPPGKAGAVAS--------QTKAGKPEEDSESSSEESSDSE-EETPAAKAL-LQA 285

Query: 1033 PASGAGEEIAEALSRPGREACLEARAHTGDGAKPDSPQKETLEVENQQEGGLKPLAQEHG 1092
             ASG   ++  A S P +E+  +       GA P  P K    V   Q G  +  +Q   
Sbjct: 286  KASGKTSQVGAA-SAPAKESPRK-------GAAPAPPGKTGPAVAKAQAGKREEDSQSSS 337

Query: 1093 PRSALGGAREVPDAPPAACPEVSQARLLSPAREE-RGLSGKSTPEPTLPSAVATEASLDS 1151
              S           P    P+V  A   +PA+E  R  +  + P  T P+A   +     
Sbjct: 338  EESDSEEEAPAQAKPSGKAPQVRAAS--APAKESPRKGAAPAPPRKTGPAAAQVQVGKQE 395

Query: 1152 CPESSVGAVSSLDRGCPDAPAPTSAPTSQQPEPVLGLGSVEQPHEVPSVLGTPLLQPPEN 1211
                S    S  DR         +A  + Q +P   LG             +P ++P   
Sbjct: 396  EDSRSSSEESDSDREA------LAAMNAAQVKP---LGK------------SPQVKPAST 434

Query: 1212 LAKGQPSTPVDRPLGPDPSAPGTLAGAALPPLEPPAPCLCQDPQEDSVEDEEPPGSLGLP 1271
            +  G    P+ +  GP P  PG +      P  P A     +   +S  +E    S G  
Sbjct: 435  MGMG----PLGKGAGPVP--PGKVG-----PATPSAQVGKWEEDSESSSEESSDSSDGEV 483

Query: 1272 PPQAGVQPAAAAVSGTTQPLGTGPRVSLSPHSPLLSPKVASMDAKDLALQILPPCQVPPP 1331
            P    V PA     G                  +L  K  S  AK               
Sbjct: 484  P--TAVAPAQEKSLGN-----------------ILQAKPTSSPAK--------------- 509

Query: 1332 SGPQSPAGPQGLSAPEQQEDEDSLEEDSPRALGSGQHSDSHGESSAELDEQDILAPQTVQ 1391
             GP   AGP  +    ++  ++S  E S  +  S    ++    +A   +  +  PQT  
Sbjct: 510  -GPPQKAGPVAVQVKAEKPMDNS--ESSEESSDSADSEEAPAAMTAAQAKPALKIPQTKA 566

Query: 1392 CPAQAPAGGSEETIAKAKQSRSEKKARKAMSKLGLR-QIQGVTRITIQKSKNILFVIAKP 1450
            CP +     S +       +++ +KA  A S  G    + G T+   + S +     ++ 
Sbjct: 567  CPKKTNTTASAKVAPVRVGTQAPRKAGTATSPAGSSPAVAGGTQRPAEDSSS-----SEE 621

Query: 1451 DVFKSPASDTYVVFGEAKIEDLSQQVHKAAAEKFK----------VPSEPSALVPESAPR 1500
               +   +   V  G+AK      QV KAA+   K          +P +    V +    
Sbjct: 622  SDSEEEKTGLAVTVGQAKSVGKGLQV-KAASVPVKGSLGQGTAPVLPGKTGPTVTQVKAE 680

Query: 1501 PRVRLECKEEEEEEEEEVDEAGLELRDIELVMAQANVSRAKAVRA 1545
             +   E  EEE + EE           ++   A+AN + A+A  A
Sbjct: 681  KQEDSESSEEESDSEEAAASPAQVKTSVKKTQAKANPAAARAPSA 725



 Score = 55.8 bits (133), Expect = 3e-07
 Identities = 169/805 (20%), Positives = 270/805 (33%), Gaps = 111/805 (13%)

Query: 328  PLSPEEEEEEAVADPDPGGDLAGEGEEDSTSASFLQSLSDL----SITEGMDEAFAFRDD 383
            P       EE+ ++ +  G     G+  S         + +    S+ +G       +  
Sbjct: 612  PAEDSSSSEESDSEEEKTGLAVTVGQAKSVGKGLQVKAASVPVKGSLGQGTAPVLPGKTG 671

Query: 384  TSAASSDSDSASYAEADDERLYSGEPHAQATLLQDSVQKTEEESGGGAKGLQAQDGTVS- 442
             +     ++    +E+ +E   S E  A    ++ SV+KT+ ++   A    +  GT+S 
Sbjct: 672  PTVTQVKAEKQEDSESSEEESDSEEAAASPAQVKTSVKKTQAKANPAAARAPSAKGTISA 731

Query: 443  --WAVEAAPQTSDRGAYLSQRQELISEVTEEGLALGQESTATVTPHTLQVAPGLQVEVAT 500
                V AA Q   R      +  + +      LA G  S  +V      VA   Q +   
Sbjct: 732  PGKVVTAAAQAKQRSP-SKVKPPVRNPQNSTVLARGPASVPSVGK---AVATAAQAQTGP 787

Query: 501  RVTPQAGEEETDSTAGQESAAMAMPQPSQEGISEIL--GQESVTAEKLPTPQEETSLTLC 558
                 + EEE+DS    E+ A   P      I   L   +ES      PTP  +T  +  
Sbjct: 788  EEDSGSSEEESDSEEEAETLAQVKPSGKTHQIRAALAPAKESPRKGAAPTPPGKTGPSAA 847

Query: 559  ----PDSPQNLKEEGGLDLPSGRKPVAAATIVPRQAKEDLTLPQDSAMTPPLPLQDTDLS 614
                 D   +  EE   D  +     +A  I P     D   P  S   P         +
Sbjct: 848  QAGKQDDSGSSSEESDSDGEAPAAVTSAQVIKPPLIFVD---PNRSPAGPAATPAQAQAA 904

Query: 615  SAPKPVAA----ATIVSQQAEEGLTLPQDSVMTPPLPLQDTELSSA-PK--PVAAATLVS 667
            S P+   A    A   S ++E+   +P    +TP +      + +A P+  P A+    S
Sbjct: 905  STPRKARASESTARSSSSESEDEDVIPATQCLTPGIRTNVVTMPTAHPRIAPKASMAGAS 964

Query: 668  QQAEEGLTLPQDSAMTPPLPLQDTDLSSAPKPVAAATLVSQQAEEGLTLPQDSAMTPPLP 727
               E            P   +   + +S P   AA  +++Q+A E        A T P  
Sbjct: 965  SSKESSRISDGKKQEGPATQVSKKNPASLPLTQAALKVLAQKASEA---QPPVARTQPSS 1021

Query: 728  LQDTDLSSAPKPVAAATLVSQQAEEGLTLPQ----DSAMTPPLPLQDTDLSSAPKPVAAA 783
              D+ + + P     +T V  +    L  P+      A   P    D++ SS        
Sbjct: 1022 GVDSAVGTLPATSPQSTSVQAKGTNKLRKPKLPEVQQATKAPESSDDSEDSSDS------ 1075

Query: 784  TIVSQQAEEGLTLPQDSAMTPPLPLQDTDLSSAPKPVAAATIVSQQAEEGLTLPQDSAMT 843
               S  +EE    PQ +     L          P P    T+V + A E     +D  + 
Sbjct: 1076 ---SSGSEEDGEGPQGAKSAHTL---------GPTPSRTETLVEETAAES---SEDDVVA 1120

Query: 844  PPLPLQDTDLSSAPKPVAAATPVSQQAEEGLTLPQDSAMTPPLPLQDTDLSSAPKPVAAA 903
            P   L    LS    P    TP + QA         S  TP L   D+  S +    A  
Sbjct: 1121 PSQSL----LSGYMTP--GLTPANSQA---------SKATPKL---DSSPSVSSTLAAKD 1162

Query: 904  TPVSQQAEEGLTLPQDSA-MTAPLPLQDTGPTSGPEPLAVATPQTLQAEAGCAPGTEPVA 962
             P  +Q  +    PQ +A M +P        T G E  +  TPQ  +     A   +   
Sbjct: 1163 DPDGKQEAK----PQQAAGMLSP-------KTGGKEAASGTTPQKSRKPKKGAGNPQAST 1211

Query: 963  TMAQQEVGEALGPRPAP-------------------EEKNAALPTVPEPAALD----QVQ 999
               Q  + + L  +P P                   +E+   + T  E +       + +
Sbjct: 1212 LALQSNITQCLLGQPWPLNEAQVQASVVKVLTELLEQERKKVVDTTKESSRKGWESRKRK 1271

Query: 1000 QDDPQPAAEAGTPWA-AQEDADSTLGMEALSLPEPASGAGEEIAEALSRPGREACLEARA 1058
                QPAA   TP +  ++   +  G EA   PE  S   +  A+     G     + + 
Sbjct: 1272 LSGDQPAAR--TPRSKKKKKLGAGEGGEASVSPEKTSTTSKGKAKRDKASGDVKEKKGKG 1329

Query: 1059 HTGDGAKPDSPQKETLEVENQQEGG 1083
              G     D P++E  +     EGG
Sbjct: 1330 SLGSQGAKDEPEEELQKGMGTVEGG 1354


>gi|239746149 PREDICTED: hypothetical protein LOC80164 [Homo sapiens]
          Length = 816

 Score = 75.9 bits (185), Expect = 3e-13
 Identities = 159/661 (24%), Positives = 210/661 (31%), Gaps = 95/661 (14%)

Query: 470  EEGLALGQEST-----ATVTPHTLQVAPGLQVEVA--TRVTPQAGEEETDSTAGQE---- 518
            ++GL +  E T     AT  P    ++ G + + +  T  TP          AG E    
Sbjct: 122  QKGLRISAEETVARGKATEAPKRSALSAGARRDTSGPTPGTPSPAMARRSRAAGTEVGLP 181

Query: 519  -SAAMAMPQPSQEGISEILGQESVTAEKLPTPQEETSLTLCPDSPQNLKEEGGLDLPSGR 577
              A  A P+P  EG  + +   S  +   P+P         P +   L+      L S  
Sbjct: 182  RPAPSARPRPPTEGPRKSVSSASEHSTTEPSPAARRR----PSAGGGLQRPASRSLSSSA 237

Query: 578  KPVAAATIVPRQAKEDLTLPQDSAMTPPLPLQDTDLSSAPKPVA-AATIVSQQAEEGLTL 636
             P+++       A+     P   +   P  LQ         P   AA  +   +   L  
Sbjct: 238  TPLSSPARSGPSARGTPRAPAHPSQPKPKGLQALRPPQVTPPRKDAAPALGPLSSSPLAT 297

Query: 637  PQDSVMTPPLPLQDTELSSAPKPVAAATLVSQQAEEGLTLPQDSAMTPPLPLQDTDLSSA 696
            P  S   PP P     L + P P A       QA   L  P   A    LP       + 
Sbjct: 298  PSPSA--PPSPSAPPSLQTLPSPPATPP---SQATTSLGSPTLQATHSFLPSPPLSPLAT 352

Query: 697  PKPVAAATLVSQQAEEGLTLPQDSAMTPPLPLQDTDLSSAPKPVAAATL---VSQQAEEG 753
            P P A   L    A   L  P     +PPL    T    AP  +A   L    S      
Sbjct: 353  PPPQAPPAL----ALPPLQAPPSPPASPPLSPLATPSPQAPNALAVHLLQAPFSPPPSPP 408

Query: 754  LTLPQDSAMTPPLPLQDTDLSSAPKPVAAATIVSQQAEEGLTLPQDSAMTPPLPLQDTDL 813
            +  P     +PP+    T  S AP  +AA           L +P     +PP+    T  
Sbjct: 409  VQAPFSPPASPPVSPSATPPSQAPPSLAAPP---------LQVPPSPPASPPMSPSATPP 459

Query: 814  SSAPKPVAAATIV----SQQAEEGLTLPQDSAMTPP---LPLQDTDLSSAPKPVAAATPV 866
              AP P+AA  +       QA   L  P   A+  P    P Q     SA  P++     
Sbjct: 460  PQAPPPLAAPPLQLAKPPPQAPPALATPPLQALPSPPASFPGQAPFSPSASLPMSPLATP 519

Query: 867  SQQAEEGLTLPQ-------------DSAMTPPLPLQDTDLSS---------APKPVAAAT 904
              QA   L  P               +   PP P  DT +S           P P  + +
Sbjct: 520  PPQAPPVLAAPLLQVPPSPPASPTLQAPRRPPTPGPDTSVSGPRLTLALAPGPPPPPSRS 579

Query: 905  PVSQQAEEGLTLPQDSAMTAPLPLQDTGPTSGPEPLAVATPQTLQAEAGCAPGT---EPV 961
            P S  +   L     SA + P  L+  G  SGPE  A A+P      A C P      P 
Sbjct: 580  PSSTLSGPDLAGHSSSATSTPEELR--GYDSGPEGGAAASPPPDAELAACHPAAWSRGPA 637

Query: 962  ATMAQQEVGEALGPRPAPE--------------EKNAALPTVPEPAALDQVQQDDPQPAA 1007
              +A +  G    P P P               E        P P ALD      P P  
Sbjct: 638  PPLAFR--GAPGAPLPWPPATGPGSADGLCTIYETEGPESATPAPGALD----PGPSPGT 691

Query: 1008 EAGTPWAAQEDADSTLGMEALSLPEPASGA--GEEIAEALSRPGREACLEARAHTGDGAK 1065
              G   A      S+   +   L E   GA     +   LSR    A  E  A  G G  
Sbjct: 692  SGGKAAAGAGAGASSRSPKQARLGELPLGALQASVVQHLLSRTLLLAAAEGAA-GGSGGG 750

Query: 1066 P 1066
            P
Sbjct: 751  P 751



 Score = 73.2 bits (178), Expect = 2e-12
 Identities = 159/614 (25%), Positives = 212/614 (34%), Gaps = 116/614 (18%)

Query: 778  KPVAAATIVSQQAEEGLTLPQDSAMTPPLPLQDTDLSSAPKPVAAATIVSQQ--AEE--- 832
            K  AAA   + +A   LT     +  PP P+    L    + + AA  V ++  AE    
Sbjct: 9    KAGAAARTPAARAPGLLTPRPPGSPRPPPPVTPAAL----RVLGAAGAVGRKPLAERAGG 64

Query: 833  --GLTLPQDSAMTPPLPLQDTDLSSAPKPVAAATPVSQQAEEGLTLP-QDSAMTPPLPLQ 889
              G T+P+ +    P        S   +    A P    +   ++ P + S  T P PL 
Sbjct: 65   IGGATIPESAPRAGPTRTSRPPASGRGE---RAPPAKNTSPGPVSSPGRASGTTRPGPLG 121

Query: 890  DTDLSSAPKPVAAATPVSQQAEEGLTLPQDSAMTAPLPLQDTGPTSGPEPLAVATPQTLQ 949
               L  + +   A    ++        P+ SA++A      +GPT G       TP    
Sbjct: 122  QKGLRISAEETVARGKATEA-------PKRSALSAGARRDTSGPTPG-------TPSPAM 167

Query: 950  AEAGCAPGTEPVATMAQQEVGEALGPRPAPEEKNAALPTVPEPAALDQVQQDDPQPAAEA 1009
            A    A GTE         VG    PRPAP    +A P  P       V         E 
Sbjct: 168  ARRSRAAGTE---------VGL---PRPAP----SARPRPPTEGPRKSVSSASEHSTTE- 210

Query: 1010 GTPWAAQEDADSTLGMEALSLPEPASGAGEEIAEALSRPGREACLEARAHTGDGAKPDSP 1069
              P  A     S  G     L  PAS +    A  LS P R     AR      A P  P
Sbjct: 211  --PSPAARRRPSAGG----GLQRPASRSLSSSATPLSSPARSGP-SARGTPRAPAHPSQP 263

Query: 1070 QKETLEVEN--QQEGGLKPLAQEHGPRSALGGAREVPDAPPAACPEVSQARLLSP----- 1122
            + + L+     Q     K  A   GP S+   A   P APP+     S   L SP     
Sbjct: 264  KPKGLQALRPPQVTPPRKDAAPALGPLSSSPLATPSPSAPPSPSAPPSLQTLPSPPATPP 323

Query: 1123 --AREERG---------------LSGKSTPEPTLPSAVATEASLDSCPESSVGAVSSLDR 1165
              A    G               LS  +TP P  P A+A           +   +S L  
Sbjct: 324  SQATTSLGSPTLQATHSFLPSPPLSPLATPPPQAPPALALPPLQAPPSPPASPPLSPLAT 383

Query: 1166 GCPDAPAPTS-----APTSQQPEPVLGLGSVEQPHEVP-----SVLGTPLLQPPENLAKG 1215
              P AP   +     AP S  P P      V+ P   P     S   TP  Q P +LA  
Sbjct: 384  PSPQAPNALAVHLLQAPFSPPPSP-----PVQAPFSPPASPPVSPSATPPSQAPPSLA-- 436

Query: 1216 QPSTPVDRPLGPDPSAPGTLAGAALPPLEPPAPCLCQDPQEDSVEDEEPPGSLGLPPPQA 1275
              + P+  P  P P A   ++ +A PP + P P               PP  L  PPPQA
Sbjct: 437  --APPLQVP--PSPPASPPMSPSATPPPQAPPPLAA------------PPLQLAKPPPQA 480

Query: 1276 GVQPAAAAVSGTTQPLGTGP-RVSLSPHSPLLSPKVASMDAKDLALQILPPCQVPPPSGP 1334
                A   +     P  + P +   SP + L    +A+   +   +   P  QV PPS P
Sbjct: 481  PPALATPPLQALPSPPASFPGQAPFSPSASLPMSPLATPPPQAPPVLAAPLLQV-PPSPP 539

Query: 1335 QSPAGPQGLSAPEQ 1348
             SP     L AP +
Sbjct: 540  ASPT----LQAPRR 549



 Score = 66.2 bits (160), Expect = 2e-10
 Identities = 145/580 (25%), Positives = 190/580 (32%), Gaps = 86/580 (14%)

Query: 617  PKPVAAATIVSQQAEEGLTLPQDSVMT-PPLPLQDTELSSA-------PKPVAAATLVSQ 668
            P P  A    +   E GL  P  S    PP       +SSA       P P A       
Sbjct: 163  PSPAMARRSRAAGTEVGLPRPAPSARPRPPTEGPRKSVSSASEHSTTEPSPAARRR---P 219

Query: 669  QAEEGLTLPQD---SAMTPPLPLQDTDLSSAPKPVAAATLVSQQAEEGLTLPQDSAMTPP 725
             A  GL  P     S+   PL        SA     A    SQ   +GL   +   +TPP
Sbjct: 220  SAGGGLQRPASRSLSSSATPLSSPARSGPSARGTPRAPAHPSQPKPKGLQALRPPQVTPP 279

Query: 726  LPLQDTDLSSAPKPVAAATLVSQQAEEGLTLPQDSAMTPPLPLQDTDLSSAPKPVAAATI 785
                  D + A  P++++ L +         P  SA  PP P     L + P P A    
Sbjct: 280  RK----DAAPALGPLSSSPLAT---------PSPSA--PPSPSAPPSLQTLPSPPATPP- 323

Query: 786  VSQQAEEGLTLPQDSAMTPPLPLQDTDLSSAPKPVAAATIVSQQAEEGLTLPQDSAMTPP 845
               QA   L  P   A    LP       + P P A   +    A   L  P     +PP
Sbjct: 324  --SQATTSLGSPTLQATHSFLPSPPLSPLATPPPQAPPAL----ALPPLQAPPSPPASPP 377

Query: 846  LPLQDTDLSSAPKPVAA---ATPVSQQAEEGLTLPQDSAMTPPLPLQDTDLSSAPKPVAA 902
            L    T    AP  +A      P S      +  P     +PP+    T  S AP  +AA
Sbjct: 378  LSPLATPSPQAPNALAVHLLQAPFSPPPSPPVQAPFSPPASPPVSPSATPPSQAPPSLAA 437

Query: 903  -------ATPVSQQAEEGLTLPQDSA--MTAPLPLQDTGPTSGPEPLAVATP--QTLQAE 951
                   + P S       T P  +   + AP PLQ   P     P A+ATP  Q L + 
Sbjct: 438  PPLQVPPSPPASPPMSPSATPPPQAPPPLAAP-PLQLAKPPPQAPP-ALATPPLQALPSP 495

Query: 952  AGCAPGTEPVATMAQQEVGEALGPRP-APEEKNAALPTVPEPAALDQVQQDDPQPAAEAG 1010
                PG  P +  A   +     P P AP    A L  VP         Q   +P     
Sbjct: 496  PASFPGQAPFSPSASLPMSPLATPPPQAPPVLAAPLLQVPPSPPASPTLQAPRRP----- 550

Query: 1011 TPWAAQEDADSTLGMEALSLPEPASGAGEEIAEALSRPGREACLEARAHTGDGAKPDSPQ 1070
             P    + + S   +     P P        +  LS P            G  +   S  
Sbjct: 551  -PTPGPDTSVSGPRLTLALAPGPPPPPSRSPSSTLSGPDL---------AGHSSSATSTP 600

Query: 1071 KETLEVENQQEGGLKPLAQEHGPRSALGGAREVPDAPPAACPEVSQARLLSPAREERGLS 1130
            +E    ++  EGG                A   PDA  AAC   + +R  +P    RG  
Sbjct: 601  EELRGYDSGPEGG--------------AAASPPPDAELAACHPAAWSRGPAPPLAFRGAP 646

Query: 1131 GKSTPEP--TLPSAVATEASL--DSCPESSVGAVSSLDRG 1166
            G   P P  T P +     ++     PES+  A  +LD G
Sbjct: 647  GAPLPWPPATGPGSADGLCTIYETEGPESATPAPGALDPG 686



 Score = 56.6 bits (135), Expect = 2e-07
 Identities = 181/781 (23%), Positives = 243/781 (31%), Gaps = 119/781 (15%)

Query: 720  SAMTPPLPLQDTDLS-SAPKPVAAATLVSQQAEEGLTLPQDSAMTPPLPLQDTDLSSAPK 778
            S  T P PL    L  SA + VA            L+       + P P         P 
Sbjct: 112  SGTTRPGPLGQKGLRISAEETVARGKATEAPKRSALSAGARRDTSGPTP-------GTPS 164

Query: 779  PVAAATIVSQQAEEGLTLPQDSAMTPPLPLQDTDLSSAPKPVAAATIVSQQAEEGLTLPQ 838
            P  A    +   E GL  P  SA   P P +    S           VS  +E   T P 
Sbjct: 165  PAMARRSRAAGTEVGLPRPAPSARPRP-PTEGPRKS-----------VSSASEHSTTEPS 212

Query: 839  DSAMTPPLPLQDTDLSSAPKPVAAATPVSQQAEEGLTLPQDSAMTPPLPLQDTDLSSAPK 898
             +A   P         ++    ++ATP+S  A  G      +  TP  P   +     PK
Sbjct: 213  PAARRRPSAGGGLQRPASRSLSSSATPLSSPARSG----PSARGTPRAPAHPSQ--PKPK 266

Query: 899  PVAAATPVSQQAEEGLTLPQDSAMTA--PL---PLQDTGPTSGPEPLAVATPQTLQAEAG 953
             + A  P        +T P+  A  A  PL   PL    P++ P P A  + QTL +   
Sbjct: 267  GLQALRPPQ------VTPPRKDAAPALGPLSSSPLATPSPSAPPSPSAPPSLQTLPSPPA 320

Query: 954  CAPG--TEPVATMAQQEVGEALGPRPAPEEKNAALPTVPEPAALDQVQQDDPQPAAEAGT 1011
              P   T  + +   Q     L P P         P  P   AL  +Q     PA+   +
Sbjct: 321  TPPSQATTSLGSPTLQATHSFL-PSPPLSPLATPPPQAPPALALPPLQAPPSPPASPPLS 379

Query: 1012 PWAAQE-DADSTLGMEALSLP---EPASGAGEEIAEALSRPGREACLEARAHTGDGAKPD 1067
            P A     A + L +  L  P    P+       +   S P   +           A P 
Sbjct: 380  PLATPSPQAPNALAVHLLQAPFSPPPSPPVQAPFSPPASPPVSPSATPPSQAPPSLAAPP 439

Query: 1068 SPQKETLEVENQQEGGLKPLAQEHGPRSA--LGGAREVPDAPPAACPEVSQARLLSPARE 1125
                 +            P  Q   P +A  L  A+  P APPA      QA L SP   
Sbjct: 440  LQVPPSPPASPPMSPSATPPPQAPPPLAAPPLQLAKPPPQAPPALATPPLQA-LPSPPAS 498

Query: 1126 ERG-----------LSGKSTPEPTLPSAVATEASLDSCPESSVGAVSSLDRGCPDAPAPT 1174
              G           +S  +TP P  P  +A  A L   P S     +S     P  P PT
Sbjct: 499  FPGQAPFSPSASLPMSPLATPPPQAPPVLA--APLLQVPPSPP---ASPTLQAPRRP-PT 552

Query: 1175 SAPTSQQPEPVLGLGSVEQPHEVPSVLGTPLLQPPENLAKGQPSTPVDRPLGPDPSAPGT 1234
              P +    P L L     P   PS   +  L  P+       +T     L    S P  
Sbjct: 553  PGPDTSVSGPRLTLALAPGPPPPPSRSPSSTLSGPDLAGHSSSATSTPEELRGYDSGPEG 612

Query: 1235 LAGAALPPLEPPAPCLCQDPQEDSVEDEEPPGSLGLPPPQAGVQPAAAAVSGTTQPLGTG 1294
             A A+ PP    A C                             PAA +  G   PL   
Sbjct: 613  GAAASPPPDAELAAC----------------------------HPAAWS-RGPAPPLA-- 641

Query: 1295 PRVSLSPHSPLLSPKVASMDAKDLALQILPPCQVPPPSGPQSPAGPQGLSAPEQQEDEDS 1354
                 +P +PL  P      + D        C +    GP+S     G   P        
Sbjct: 642  --FRGAPGAPLPWPPATGPGSAD------GLCTIYETEGPESATPAPGALDPGPSPGTSG 693

Query: 1355 LEEDSPRALGSGQHSDSHGESSAELDE-----------QDILAPQTVQCPAQAPAGGSEE 1403
                   A G+G  + S     A L E           Q +L+   +   A+  AGGS  
Sbjct: 694  ----GKAAAGAGAGASSRSPKQARLGELPLGALQASVVQHLLSRTLLLAAAEGAAGGSGG 749

Query: 1404 TIAKAKQSRSEKKARKAMSKLGLRQIQGVTRITIQKSKNILFVIA-KPDVFKSPASDTYV 1462
                A+       AR A+S   L +   +     +   +I  V +  PD   SP  D  V
Sbjct: 750  GPGGAEGGGVTGGARAALSDAELGRWAELLSPLDESRASITSVTSFSPDDVASPQGDWTV 809

Query: 1463 V 1463
            V
Sbjct: 810  V 810



 Score = 38.1 bits (87), Expect = 0.067
 Identities = 76/342 (22%), Positives = 108/342 (31%), Gaps = 45/342 (13%)

Query: 27  DAAAATTILGGDRREPCALTPGPSHLALTF----------LPSK-PGARPQP-------- 67
           +A   + +  G RR+    TPG    A+            LP   P ARP+P        
Sbjct: 140 EAPKRSALSAGARRDTSGPTPGTPSPAMARRSRAAGTEVGLPRPAPSARPRPPTEGPRKS 199

Query: 68  -EGASWDAGPGGAPSAWADPGEGGPSPMLLPEGLSSQALSTEAPLPATLEPRIVMGEETC 126
              AS  +    +P+A   P  GG         LSS A    +P  +    R        
Sbjct: 200 VSSASEHSTTEPSPAARRRPSAGGGLQRPASRSLSSSATPLSSPARSGPSARGTPRAPAH 259

Query: 127 QALLSPRAARTALRDQEGGHASPDPPPEL--CSQGDLSVPSP--PPDPDSFFTPPSTPTK 182
            +   P+  + ALR  +      D  P L   S   L+ PSP  PP P +   PPS  T 
Sbjct: 260 PSQPKPKGLQ-ALRPPQVTPPRKDAAPALGPLSSSPLATPSPSAPPSPSA---PPSLQTL 315

Query: 183 TTYALLPACGPHGDARDSEAELRDELLDSPPASPSGSYITADGDSWASSPSCSLSLLAPA 242
            +    P             +     L SPP SP  +       + A  P  +     P+
Sbjct: 316 PSPPATPPSQATTSLGSPTLQATHSFLPSPPLSPLATPPPQAPPALALPPLQA----PPS 371

Query: 243 EGLDFPSGWGLSPQGSMVDERELHPAGTPEPPSSESSLSADSSSSWGQEGHFFDLDFLAN 302
                P     +P     +   +H    P  P     + A  S               A+
Sbjct: 372 PPASPPLSPLATPSPQAPNALAVHLLQAPFSPPPSPPVQAPFSPP-------------AS 418

Query: 303 DPMIPAALLPFQGSLIFQVEAVEVTPLSPEEEEEEAVADPDP 344
            P+ P+A  P Q         ++V P  P        A P P
Sbjct: 419 PPVSPSATPPSQAPPSLAAPPLQVPPSPPASPPMSPSATPPP 460



 Score = 38.1 bits (87), Expect = 0.067
 Identities = 51/212 (24%), Positives = 75/212 (35%), Gaps = 32/212 (15%)

Query: 13  PEADRPGPRTDLSCDAAAATTILGGDRREPCALTPGPSHLALTFLPSKPGARPQPEGASW 72
           P     GPR  +S  +  +TT             P P   A    PS  G   +P   S 
Sbjct: 189 PRPPTEGPRKSVSSASEHSTT------------EPSP---AARRRPSAGGGLQRPASRSL 233

Query: 73  DAGPGGAPSAWADPGEGGPSPMLLPEGLSSQALSTEAPLPATLEPRIVMGEETCQALLSP 132
            +    + +  + P   GPS    P   +  +      L A   P++    +     L P
Sbjct: 234 SS----SATPLSSPARSGPSARGTPRAPAHPSQPKPKGLQALRPPQVTPPRKDAAPALGP 289

Query: 133 RAARTALRDQEGGHASPDPPPELCSQGDLSVPSPPPDPDSFFTPP-STPT-KTTYALLPA 190
            ++            SP  PP L      ++PSPP  P S  T    +PT + T++ LP+
Sbjct: 290 LSSSPLATPSPSAPPSPSAPPSL-----QTLPSPPATPPSQATTSLGSPTLQATHSFLPS 344

Query: 191 ------CGPHGDARDSEAELRDELLDSPPASP 216
                   P   A  + A    +   SPPASP
Sbjct: 345 PPLSPLATPPPQAPPALALPPLQAPPSPPASP 376



 Score = 34.3 bits (77), Expect = 0.97
 Identities = 74/262 (28%), Positives = 90/262 (34%), Gaps = 41/262 (15%)

Query: 31  ATTILGGDRREPCALTPGPSHLALTFLPSKPGARPQPEGASWDAGPG--GAPSAWADPGE 88
           ATT LG         T   +H  L   P  P A P P+     A P     PS  A P  
Sbjct: 326 ATTSLGSP-------TLQATHSFLPSPPLSPLATPPPQAPPALALPPLQAPPSPPASPPL 378

Query: 89  GGPSPMLLPEGLSSQALST---EAPLPATLEPRIVMGEETCQALLSPRAARTALRDQEGG 145
              SP+  P   +  AL+    +AP      P +       QA  SP A+          
Sbjct: 379 ---SPLATPSPQAPNALAVHLLQAPFSPPPSPPV-------QAPFSPPASPPV-----SP 423

Query: 146 HASP--DPPPELCSQGDLSVPSPPPDPD---SFFTPPSTPTKTTYALLPACGPHGDARDS 200
            A+P    PP L +      PSPP  P    S   PP  P       L    P   A  +
Sbjct: 424 SATPPSQAPPSLAAPPLQVPPSPPASPPMSPSATPPPQAPPPLAAPPLQLAKPPPQAPPA 483

Query: 201 EAELRDELLDSPPASPSGSYITADGDSWASSPSCSLSLLAP----AEGLDFPSGWGLSPQ 256
            A    + L SPPAS  G    +   S   SP  +    AP    A  L  P     SP 
Sbjct: 484 LATPPLQALPSPPASFPGQAPFSPSASLPMSPLATPPPQAPPVLAAPLLQVPP----SPP 539

Query: 257 GSMVDERELHPAGTPEPPSSES 278
            S   +    P  TP P +S S
Sbjct: 540 ASPTLQAPRRPP-TPGPDTSVS 560


  Database: hs.faa
    Posted date:  Aug 4, 2009  4:42 PM
  Number of letters in database: 18,247,518
  Number of sequences in database:  37,866
  
Lambda     K      H
   0.306    0.125    0.355 

Gapped
Lambda     K      H
   0.267   0.0410    0.140 


Matrix: BLOSUM62
Gap Penalties: Existence: 11, Extension: 1
Number of Hits to DB: 79,089,455
Number of Sequences: 37866
Number of extensions: 5252467
Number of successful extensions: 38999
Number of sequences better than 10.0: 30
Number of HSP's better than 10.0 without gapping: 161
Number of HSP's successfully gapped in prelim test: 1773
Number of HSP's that attempted gapping in prelim test: 21612
Number of HSP's gapped (non-prelim): 13739
length of query: 1562
length of database: 18,247,518
effective HSP length: 116
effective length of query: 1446
effective length of database: 13,855,062
effective search space: 20034419652
effective search space used: 20034419652
T: 11
A: 40
X1: 16 ( 7.1 bits)
X2: 38 (14.6 bits)
X3: 64 (24.7 bits)
S1: 43 (22.0 bits)
S2: 69 (31.2 bits)

Search results were obtained with NCBI BLAST and RefSeq entries.


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Guide to the Human Genome
Copyright © 2010 by Stewart Scherer. All rights reserved.

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