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Search of human proteins with 226371731
BLASTP 2.2.11 [Jun-05-2005]
Reference: Altschul, Stephen F., Thomas L. Madden, Alejandro A. Schaffer,
Jinghui Zhang, Zheng Zhang, Webb Miller, and David J. Lipman (1997),
"Gapped BLAST and PSI-BLAST: a new generation of protein database search
programs", Nucleic Acids Res. 25:3389-3402.
Query= gi|226371731 hydroxysteroid dehydrogenase like 1 isoform a
[Homo sapiens]
(330 letters)
Database: hs.faa
37,866 sequences; 18,247,518 total letters
Searching..................................................done
Score E
Sequences producing significant alignments: (bits) Value
gi|226371731 hydroxysteroid dehydrogenase like 1 isoform a [Homo... 665 0.0
gi|226371733 hydroxysteroid dehydrogenase like 1 isoform b [Homo... 496 e-140
gi|7705855 hydroxysteroid (17-beta) dehydrogenase 12 [Homo sapiens] 226 2e-59
gi|4557649 estradiol 17 beta-dehydrogenase 3 [Homo sapiens] 162 3e-40
gi|32483357 peroxisomal short-chain alcohol dehydrogenase [Homo ... 75 1e-13
gi|210032110 hydroxysteroid (17-beta) dehydrogenase 13 isoform A... 73 3e-13
gi|5031737 dehydrogenase/reductase member 2 isoform 2 [Homo sapi... 72 5e-13
gi|142976729 estradiol 17-beta-dehydrogenase 11 [Homo sapiens] 70 3e-12
gi|33667109 dehydrogenase/reductase member 2 isoform 1 [Homo sap... 70 3e-12
gi|20149619 dehydrogenase/reductase (SDR family) member 7B [Homo... 70 3e-12
gi|126723191 dehydrogenase/reductase (SDR family) member 4 like ... 66 4e-11
gi|7706318 dehydrogenase/reductase (SDR family) member 7 [Homo s... 64 1e-10
gi|166795268 retinol dehydrogenase 11 [Homo sapiens] 62 5e-10
gi|40254992 carbonic reductase 4 [Homo sapiens] 62 7e-10
gi|225579078 retinol dehydrogenase 13 isoform 1 [Homo sapiens] 59 5e-09
gi|150247226 retinol dehydrogenase 16 [Homo sapiens] 59 5e-09
gi|44680136 3-hydroxybutyrate dehydrogenase, type 1 precursor [H... 59 6e-09
gi|44680133 3-hydroxybutyrate dehydrogenase, type 1 precursor [H... 59 6e-09
gi|17738292 3-hydroxybutyrate dehydrogenase, type 1 precursor [H... 59 6e-09
gi|31543615 dehydrogenase/reductase (SDR family) member 3 [Homo ... 58 1e-08
gi|40807363 epidermal retinal dehydrogenase 2 [Homo sapiens] 58 1e-08
gi|4503817 3-ketodihydrosphingosine reductase precursor [Homo sa... 57 2e-08
gi|22507405 short chain dehydrogenase/reductase family 9C, membe... 57 2e-08
gi|126723750 dehydrogenase/reductase (SDR family) member 4 like ... 57 2e-08
gi|7705925 dicarbonyl/L-xylulose reductase [Homo sapiens] 57 3e-08
gi|66933014 3-hydroxybutyrate dehydrogenase, type 2 [Homo sapiens] 56 4e-08
gi|32455239 11-beta-hydroxysteroid dehydrogenase 1 [Homo sapiens] 56 5e-08
gi|5031765 11-beta-hydroxysteroid dehydrogenase 1 [Homo sapiens] 56 5e-08
gi|19743808 hydroxysteroid (17-beta) dehydrogenase 6 [Homo sapiens] 55 7e-08
gi|193804850 dehydrogenase/reductase (SDR family) X-linked [Homo... 55 9e-08
>gi|226371731 hydroxysteroid dehydrogenase like 1 isoform a [Homo
sapiens]
Length = 330
Score = 665 bits (1715), Expect = 0.0
Identities = 330/330 (100%), Positives = 330/330 (100%)
Query: 1 MAAVDSFYLLYREIARSCNCYMEALALVGAWYTARKSITVICDFYSLIRLHFIPRLGSRA 60
MAAVDSFYLLYREIARSCNCYMEALALVGAWYTARKSITVICDFYSLIRLHFIPRLGSRA
Sbjct: 1 MAAVDSFYLLYREIARSCNCYMEALALVGAWYTARKSITVICDFYSLIRLHFIPRLGSRA 60
Query: 61 DLIKQYGRWAVVSGATDGIGKAYAEELASRGLNIILISRNEEKLQVVAKDIADTYKVETD 120
DLIKQYGRWAVVSGATDGIGKAYAEELASRGLNIILISRNEEKLQVVAKDIADTYKVETD
Sbjct: 61 DLIKQYGRWAVVSGATDGIGKAYAEELASRGLNIILISRNEEKLQVVAKDIADTYKVETD 120
Query: 121 IIVADFSSGREIYLPIREALKDKDVGILVNNVGVFYPYPQYFTQLSEDKLWDIINVNIAA 180
IIVADFSSGREIYLPIREALKDKDVGILVNNVGVFYPYPQYFTQLSEDKLWDIINVNIAA
Sbjct: 121 IIVADFSSGREIYLPIREALKDKDVGILVNNVGVFYPYPQYFTQLSEDKLWDIINVNIAA 180
Query: 181 ASLMVHVVLPGMVERKKGAIVTISSGSCCKPTPQLAAFSASKAYLDHFSRALQYEYASKG 240
ASLMVHVVLPGMVERKKGAIVTISSGSCCKPTPQLAAFSASKAYLDHFSRALQYEYASKG
Sbjct: 181 ASLMVHVVLPGMVERKKGAIVTISSGSCCKPTPQLAAFSASKAYLDHFSRALQYEYASKG 240
Query: 241 IFVQSLIPFYVATSMTAPSNFLHRCSWLVPSPKVYAHHAVSTLGISKRTTGYWSHSIQFL 300
IFVQSLIPFYVATSMTAPSNFLHRCSWLVPSPKVYAHHAVSTLGISKRTTGYWSHSIQFL
Sbjct: 241 IFVQSLIPFYVATSMTAPSNFLHRCSWLVPSPKVYAHHAVSTLGISKRTTGYWSHSIQFL 300
Query: 301 FAQYMPEWLWVWGANILNRSLRKEALSCTA 330
FAQYMPEWLWVWGANILNRSLRKEALSCTA
Sbjct: 301 FAQYMPEWLWVWGANILNRSLRKEALSCTA 330
>gi|226371733 hydroxysteroid dehydrogenase like 1 isoform b [Homo
sapiens]
Length = 275
Score = 496 bits (1276), Expect = e-140
Identities = 262/330 (79%), Positives = 265/330 (80%), Gaps = 55/330 (16%)
Query: 1 MAAVDSFYLLYREIARSCNCYMEALALVGAWYTARKSITVICDFYSLIRLHFIPRLGSRA 60
MAAVDSFYLLYREIARSCNCYMEALALVGAWYTARKSITVICDFYSLIRLHFIPRLGSRA
Sbjct: 1 MAAVDSFYLLYREIARSCNCYMEALALVGAWYTARKSITVICDFYSLIRLHFIPRLGSRA 60
Query: 61 DLIKQYGRWAVVSGATDGIGKAYAEELASRGLNIILISRNEEKLQVVAKDIADTYKVETD 120
DLIKQYGRWAVVSGATDGIGKAY A+++A
Sbjct: 61 DLIKQYGRWAVVSGATDGIGKAY------------------------AEELA-------- 88
Query: 121 IIVADFSSGREIYLPIREALKDKDVGILVNNVGVFYPYPQYFTQLSEDKLWDIINVNIAA 180
S G I L R K QYFTQLSEDKLWDIINVNIAA
Sbjct: 89 ------SRGLNIILISRNEEK-----------------LQYFTQLSEDKLWDIINVNIAA 125
Query: 181 ASLMVHVVLPGMVERKKGAIVTISSGSCCKPTPQLAAFSASKAYLDHFSRALQYEYASKG 240
ASLMVHVVLPGMVERKKGAIVTISSGSCCKPTPQLAAFSASKAYLDHFSRALQYEYASKG
Sbjct: 126 ASLMVHVVLPGMVERKKGAIVTISSGSCCKPTPQLAAFSASKAYLDHFSRALQYEYASKG 185
Query: 241 IFVQSLIPFYVATSMTAPSNFLHRCSWLVPSPKVYAHHAVSTLGISKRTTGYWSHSIQFL 300
IFVQSLIPFYVATSMTAPSNFLHRCSWLVPSPKVYAHHAVSTLGISKRTTGYWSHSIQFL
Sbjct: 186 IFVQSLIPFYVATSMTAPSNFLHRCSWLVPSPKVYAHHAVSTLGISKRTTGYWSHSIQFL 245
Query: 301 FAQYMPEWLWVWGANILNRSLRKEALSCTA 330
FAQYMPEWLWVWGANILNRSLRKEALSCTA
Sbjct: 246 FAQYMPEWLWVWGANILNRSLRKEALSCTA 275
>gi|7705855 hydroxysteroid (17-beta) dehydrogenase 12 [Homo sapiens]
Length = 312
Score = 226 bits (577), Expect = 2e-59
Identities = 122/304 (40%), Positives = 188/304 (61%), Gaps = 10/304 (3%)
Query: 28 VGAWYTARKSITVICDFYSLIRLHFIPRLGSRADLIKQYGRWAVVSGATDGIGKAYAEEL 87
VGA A ++ + ++ +R+ + G+ A + G WAVV+G+TDGIGK+YAEEL
Sbjct: 14 VGAGTVAYLALRISYSLFTALRVWGV---GNEAGVGPGLGEWAVVTGSTDGIGKSYAEEL 70
Query: 88 ASRGLNIILISRNEEKLQVVAKDIADTYKVETDIIVADFSSGREIYLPIREALKDKDVGI 147
A G+ ++LISR+++KL V+ +I + +KVET I DF+S +IY I+ L ++GI
Sbjct: 71 AKHGMKVVLISRSKDKLDQVSSEIKEKFKVETRTIAVDFAS-EDIYDKIKTGLAGLEIGI 129
Query: 148 LVNNVGVFYPYPQYFTQLSE--DKLWDIINVNIAAASLMVHVVLPGMVERKKGAIVTISS 205
LVNNVG+ Y YP+YF + + + + +IN+NI + M +VLPGMVER KGAI+ ISS
Sbjct: 130 LVNNVGMSYEYPEYFLDVPDLDNVIKKMININILSVCKMTQLVLPGMVERSKGAILNISS 189
Query: 206 GSCCKPTPQLAAFSASKAYLDHFSRALQYEYASKGIFVQSLIPFYVATSMTAPSNFLHRC 265
GS P P L +SA+K ++D FS+ L EY SKG+FVQS++P++VAT + + +
Sbjct: 190 GSGMLPVPLLTIYSATKTFVDFFSQCLHEEYRSKGVFVQSVLPYFVATKLAK----IRKP 245
Query: 266 SWLVPSPKVYAHHAVSTLGISKRTTGYWSHSIQFLFAQYMPEWLWVWGANILNRSLRKEA 325
+ PSP+ + A+ T+G+ RT GY H++ +P W+++ +N+S R
Sbjct: 246 TLDKPSPETFVKSAIKTVGLQSRTNGYLIHALMGSIISNLPSWIYLKIVMNMNKSTRAHY 305
Query: 326 LSCT 329
L T
Sbjct: 306 LKKT 309
>gi|4557649 estradiol 17 beta-dehydrogenase 3 [Homo sapiens]
Length = 310
Score = 162 bits (411), Expect = 3e-40
Identities = 98/253 (38%), Positives = 148/253 (58%), Gaps = 7/253 (2%)
Query: 63 IKQYGRWAVVSGATDGIGKAYAEELASRGLNIILISRNEEKLQVVAKDIADTYKVETDII 122
++ G+WAV++GA DGIGKAY+ ELA RGLN++LISR EKL+ +A +I T II
Sbjct: 44 LRSMGQWAVITGAGDGIGKAYSFELAKRGLNVVLISRTLEKLEAIATEIERTTGRSVKII 103
Query: 123 VADFSSGREIYLPIREALKDKDVGILVNNVGVFYPY-PQYFTQLSEDKLWDIINVNIAAA 181
ADF+ +IY I+E L ++GILVNNVG+ P +F + D++ +I+ NI +
Sbjct: 104 QADFTKD-DIYEHIKEKLAGLEIGILVNNVGMLPNLLPSHFLN-APDEIQSLIHCNITSV 161
Query: 182 SLMVHVVLPGMVERKKGAIVTISSGSCCKPTPQLAAFSASKAYLDHFSRALQYEYASKGI 241
M ++L M R+KG I+ ISSG P P + +SASKA++ FS+ALQ EY +K +
Sbjct: 162 VKMTQLILKHMESRQKGLILNISSGIALFPWPLYSMYSASKAFVCAFSKALQEEYKAKEV 221
Query: 242 FVQSLIPFYVATSMTAPSNFLHRCSWLVPSPKVYAHHAVSTLGISKRTTGYWSHSIQFLF 301
+Q L P+ V+T+MT N + + + + +++ + I T G +H I F
Sbjct: 222 IIQVLTPYAVSTAMTKYLN----TNVITKTADEFVKESLNYVTIGGETCGCLAHEILAGF 277
Query: 302 AQYMPEWLWVWGA 314
+P W + GA
Sbjct: 278 LSLIPAWAFYSGA 290
>gi|32483357 peroxisomal short-chain alcohol dehydrogenase [Homo
sapiens]
Length = 278
Score = 74.7 bits (182), Expect = 1e-13
Identities = 56/189 (29%), Positives = 97/189 (51%), Gaps = 5/189 (2%)
Query: 70 AVVSGATDGIGKAYAEELASRGLNIILISRNEEKL-QVVAKDIADTYKVETDIIVADFSS 128
A+V+ +TDGIG A A LA G ++++ SR ++ + Q VA + V + +
Sbjct: 35 ALVTASTDGIGFAIARRLAQDGAHVVVSSRKQQNVDQAVATLQGEGLSVTGTVCHVGKAE 94
Query: 129 GREIYLPIREALKDKDVGILVNNVGVFYPYPQYFTQLSEDKLWD-IINVNIAAASLMVHV 187
RE + L + ILV+N V P+ ++E+ +WD +++N+ A +LM
Sbjct: 95 DRERLVATAVKLHG-GIDILVSNAAV-NPFFGSIMDVTEE-VWDKTLDINVKAPALMTKA 151
Query: 188 VLPGMVERKKGAIVTISSGSCCKPTPQLAAFSASKAYLDHFSRALQYEYASKGIFVQSLI 247
V+P M +R G++V +SS + P+P + ++ SK L ++ L E A + I V L
Sbjct: 152 VVPEMEKRGGGSVVIVSSIAAFSPSPGFSPYNVSKTALLGLTKTLAIELAPRNIRVNCLA 211
Query: 248 PFYVATSMT 256
P + TS +
Sbjct: 212 PGLIKTSFS 220
>gi|210032110 hydroxysteroid (17-beta) dehydrogenase 13 isoform A
[Homo sapiens]
Length = 300
Score = 73.2 bits (178), Expect = 3e-13
Identities = 64/223 (28%), Positives = 97/223 (43%), Gaps = 12/223 (5%)
Query: 38 ITVICDFYSLIRLHFIPRLGSRADLIKQYGRWAVVSGATDGIGKAYAEELASRGLNIILI 97
IT+I + + FIP+ G +++GA GIG+ E A R ++L
Sbjct: 12 ITIIYSYLESLVKFFIPQRRKSVA-----GEIVLITGAGHGIGRQTTYEFAKRQSILVLW 66
Query: 98 SRNEEKLQVVAKDIADTYKVETDIIVADFSSGREIYLPIREALKDK-DVGILVNNVGVFY 156
N+ ++ A + V V D S+ EIY + + K+ DV I+VNN G Y
Sbjct: 67 DINKRGVEETAAECRKL-GVTAHAYVVDCSNREEIYRSLNQVKKEVGDVTIVVNNAGTVY 125
Query: 157 PYPQYFTQLSEDKLWDIINVNIAAASLMVHVVLPGMVERKKGAIVTISSGSCCKPTPQLA 216
P T+ ++++ VNI + +LP M+ER G IVT++S + P L
Sbjct: 126 PADLLSTK--DEEITKTFEVNILGHFWITKALLPSMMERNHGHIVTVASVCGHEGIPYLI 183
Query: 217 AFSASKAYLDHFSRALQYE---YASKGIFVQSLIPFYVATSMT 256
+ +SK F R L E GI L P +V T T
Sbjct: 184 PYCSSKFAAVGFHRGLTSELQALGKTGIKTSCLCPVFVNTGFT 226
>gi|5031737 dehydrogenase/reductase member 2 isoform 2 [Homo
sapiens]
Length = 280
Score = 72.4 bits (176), Expect = 5e-13
Identities = 74/253 (29%), Positives = 125/253 (49%), Gaps = 22/253 (8%)
Query: 68 RWAVVSGATDGIGKAYAEELASRGLNIILISRNEEKL-QVVAKDIADTYKVETDIIVADF 126
R AVV+G+T GIG A A LA G ++++ SR ++ + + +AK + V +
Sbjct: 37 RVAVVTGSTSGIGFAIARRLARDGAHVVISSRKQQNVDRAMAKLQGEGLSVAGIVCHVGK 96
Query: 127 SSGREIYLPIREALKD-KDVGILVNNVGVFYPYPQYFTQL-SEDKLWD-IINVNIAAASL 183
+ RE + +AL+ V LV + GV P + L + +++WD I++VN+ + +L
Sbjct: 97 AEDREQL--VAKALEHCGGVDFLVCSAGV---NPLVGSTLGTSEQIWDKILSVNVKSPAL 151
Query: 184 MVHVVLPGMVERKKGAIVTISSGSCCKPTPQLAAFSASKAYLDHFSRALQYEYASKGIFV 243
++ +LP M E ++GA++ +SS + P L ++ SK L +R L E A K I V
Sbjct: 152 LLSQLLPYM-ENRRGAVILVSSIAAYNPVVALGVYNVSKTALLGLTRTLALELAPKDIRV 210
Query: 244 QSLIPFYVATSMTAPSNFLHRCSWLVPSPKVYAHHAVSTLGISKRTTGYWSHSIQFLFAQ 303
++P + T S H L + K HH + +G S+ G + FL +
Sbjct: 211 NCVVPGIIKTDF---SKVFHGNESLWKNFK--EHHQLQRIGESEDCAGI----VSFLCS- 260
Query: 304 YMPEWLWVWGANI 316
P+ +V G NI
Sbjct: 261 --PDASYVNGENI 271
>gi|142976729 estradiol 17-beta-dehydrogenase 11 [Homo sapiens]
Length = 300
Score = 69.7 bits (169), Expect = 3e-12
Identities = 65/221 (29%), Positives = 99/221 (44%), Gaps = 15/221 (6%)
Query: 38 ITVICDFYSLIRLHFIPRLGSRADLIKQYGRWAVVSGATDGIGKAYAEELASRGLNIILI 97
+ ++C S ++L FIP+ G +++GA GIG+ A E A ++L
Sbjct: 13 LLIVCSLESFVKL-FIPKRRKSVT-----GEIVLITGAGHGIGRLTAYEFAKLKSKLVLW 66
Query: 98 SRNEEKLQ-VVAKDIADTYKVETDIIVADFSSGREIYLPIREALKD-KDVGILVNNVGVF 155
N+ L+ AK KV T V D S+ +IY ++ + DV ILVNN GV
Sbjct: 67 DINKHGLEETAAKCKGLGAKVHT--FVVDCSNREDIYSSAKKVKAEIGDVSILVNNAGVV 124
Query: 156 YPYPQYFTQLSEDKLWDIINVNIAAASLMVHVVLPGMVERKKGAIVTISSGSCCKPTPQL 215
Y + TQ + ++ VN+ A LP M + G IVT++S + P L
Sbjct: 125 YTSDLFATQ--DPQIEKTFEVNVLAHFWTTKAFLPAMTKNNHGHIVTVASAAGHVSVPFL 182
Query: 216 AAFSASKAYLDHFSRALQYEYAS---KGIFVQSLIPFYVAT 253
A+ +SK F + L E A+ G+ L P +V T
Sbjct: 183 LAYCSSKFAAVGFHKTLTDELAALQITGVKTTCLCPNFVNT 223
>gi|33667109 dehydrogenase/reductase member 2 isoform 1 [Homo
sapiens]
Length = 300
Score = 69.7 bits (169), Expect = 3e-12
Identities = 58/193 (30%), Positives = 102/193 (52%), Gaps = 10/193 (5%)
Query: 68 RWAVVSGATDGIGKAYAEELASRGLNIILISRNEEKL-QVVAKDIADTYKVETDIIVADF 126
R AVV+G+T GIG A A LA G ++++ SR ++ + + +AK + V +
Sbjct: 37 RVAVVTGSTSGIGFAIARRLARDGAHVVISSRKQQNVDRAMAKLQGEGLSVAGIVCHVGK 96
Query: 127 SSGREIYLPIREALKD-KDVGILVNNVGVFYPYPQYFTQL-SEDKLWD-IINVNIAAASL 183
+ RE + +AL+ V LV + GV P + L + +++WD I++VN+ + +L
Sbjct: 97 AEDREQL--VAKALEHCGGVDFLVCSAGV---NPLVGSTLGTSEQIWDKILSVNVKSPAL 151
Query: 184 MVHVVLPGMVERKKGAIVTISSGSCCKPTPQLAAFSASKAYLDHFSRALQYEYASKGIFV 243
++ +LP M E ++GA++ +SS + P L ++ SK L +R L E A K I V
Sbjct: 152 LLSQLLPYM-ENRRGAVILVSSIAAYNPVVALGVYNVSKTALLGLTRTLALELAPKDIRV 210
Query: 244 QSLIPFYVATSMT 256
++P + T +
Sbjct: 211 NCVVPGIIKTDFS 223
>gi|20149619 dehydrogenase/reductase (SDR family) member 7B [Homo
sapiens]
Length = 325
Score = 69.7 bits (169), Expect = 3e-12
Identities = 55/192 (28%), Positives = 93/192 (48%), Gaps = 8/192 (4%)
Query: 71 VVSGATDGIGKAYAEELASRGLNIILISRNEEKLQVVAKDIADTY--KVETD---IIVAD 125
V++GAT G+GK A+ + G ++L RN L+ + +++ ++ KV+T ++ D
Sbjct: 56 VITGATSGLGKECAKVFYAAGAKLVLCGRNGGALEELIRELTASHATKVQTHKPYLVTFD 115
Query: 126 FSSGREIYLPIREALKDKD-VGILVNNVGVFYPYPQYFTQLSEDKLWDIINVNIAAASLM 184
+ I E L+ V ILVNN G+ Y T + DK ++ N +
Sbjct: 116 LTDSGAIVAAAAEILQCFGYVDILVNNAGISYRGTIMDTTVDVDKR--VMETNYFGPVAL 173
Query: 185 VHVVLPGMVERKKGAIVTISSGSCCKPTPQLAAFSASKAYLDHFSRALQYEYASKGIFVQ 244
+LP M++R++G IV ISS P +A++ASK F L+ E I V
Sbjct: 174 TKALLPSMIKRRQGHIVAISSIQGKMSIPFRSAYAASKHATQAFFDCLRAEMEQYEIEVT 233
Query: 245 SLIPFYVATSMT 256
+ P Y+ T+++
Sbjct: 234 VISPGYIHTNLS 245
>gi|126723191 dehydrogenase/reductase (SDR family) member 4 like 2
[Homo sapiens]
Length = 232
Score = 66.2 bits (160), Expect = 4e-11
Identities = 52/181 (28%), Positives = 91/181 (50%), Gaps = 9/181 (4%)
Query: 70 AVVSGATDGIGKAYAEELASRGLNIILISRNEEKL-QVVAKDIADTYKVETDIIVADFSS 128
A+V+ +TDGIG A A LA ++++ SR ++ + Q VA + V + +
Sbjct: 35 ALVTASTDGIGFAIARRLAQDRAHVVVSSRKQQNVDQAVATLQGEGLSVTGTVCHVGKAE 94
Query: 129 GREIYLPIREALKDKDVGILVNNVGVFYPYPQYFTQLSE--DKLWD-IINVNIAAASLMV 185
RE + + L + ILV+N V +F L + +++WD +++N+ A +LM
Sbjct: 95 DRERLVAMAVKLHG-GIDILVSNAAV----NPFFGSLMDVTEEVWDKTLDINVKAPALMT 149
Query: 186 HVVLPGMVERKKGAIVTISSGSCCKPTPQLAAFSASKAYLDHFSRALQYEYASKGIFVQS 245
V+P M +R G++V +SS + P+P + ++ SK L + L E A + I V
Sbjct: 150 KAVVPEMEKRGGGSVVIVSSIAAFSPSPGFSPYNVSKTALLGLNNTLAIELAPRNIRVNC 209
Query: 246 L 246
L
Sbjct: 210 L 210
>gi|7706318 dehydrogenase/reductase (SDR family) member 7 [Homo
sapiens]
Length = 339
Score = 64.3 bits (155), Expect = 1e-10
Identities = 68/264 (25%), Positives = 118/264 (44%), Gaps = 20/264 (7%)
Query: 72 VSGATDGIGKAYAEELASRGLNIILISRNEEKLQVVAKDIADTYKV-ETDIIVA--DFSS 128
V+GA+ GIG+ A +L+ G++++L +R +L+ V + + + E DI+V D +
Sbjct: 55 VTGASSGIGEELAYQLSKLGVSLVLSARRVHELERVKRRCLENGNLKEKDILVLPLDLTD 114
Query: 129 GREIYLPIREALKDKD-VGILVNNVGVFYPYPQYFTQLSEDKLWDIINVNIAAASLMVHV 187
+ L++ + ILVNN G+ T L D +I +N +
Sbjct: 115 TGSHEAATKAVLQEFGRIDILVNNGGMSQRSLCMDTSL--DVYRKLIELNYLGTVSLTKC 172
Query: 188 VLPGMVERKKGAIVTISSGSCCKPTPQLAAFSASKAYLDHFSRALQYEYAS-KGIFVQSL 246
VLP M+ERK+G IVT++S P + ASK L F L+ E A+ GI V ++
Sbjct: 173 VLPHMIERKQGKIVTVNSILGIISVPLSIGYCASKHALRGFFNGLRTELATYPGIIVSNI 232
Query: 247 IPFYVATSMTAPSNFLHRCSWLVPSPKVYAHHAVST-------LGISKRTTGYWSHSIQF 299
P V +++ ++ + + + +H ++ + ++ W F
Sbjct: 233 CPGPVQSNI-VENSLAGEVTKTIGNNGDQSHKMTTSRCVRLMLISMANDLKEVWISEQPF 291
Query: 300 LFA----QYMPEWLWVWGANILNR 319
L QYMP W W W N + +
Sbjct: 292 LLVTYLWQYMPTWAW-WITNKMGK 314
>gi|166795268 retinol dehydrogenase 11 [Homo sapiens]
Length = 318
Score = 62.4 bits (150), Expect = 5e-10
Identities = 64/217 (29%), Positives = 98/217 (45%), Gaps = 20/217 (9%)
Query: 67 GRWAVVSGATDGIGKAYAEELASRGLNIILISRNEEKLQVVAKDIADTYKVETDII-VAD 125
G+ VV+GA GIGK A+ELA RG + L R+ EK ++VAK+I T + ++ D
Sbjct: 41 GKVVVVTGANTGIGKETAKELAQRGARVYLACRDVEKGELVAKEIQTTTGNQQVLVRKLD 100
Query: 126 FSSGREIYLPIREAL-KDKDVGILVNNVGVFY-PYPQYFTQLSEDKLWDIINVNIAAASL 183
S + I + L ++K + +L+NN GV PY + + D I VN L
Sbjct: 101 LSDTKSIRAFAKGFLAEEKHLHVLINNAGVMMCPYSK-----TADGFEMHIGVNHLGHFL 155
Query: 184 MVHVVLPGMVERKKGAIVTISS-----GSCCKPTPQLAAF-SASKAYLDH------FSRA 231
+ H++L + E IV +SS G Q F +A AY F++
Sbjct: 156 LTHLLLEKLKESAPSRIVNVSSLAHHLGRIHFHNLQGEKFYNAGLAYCHSKLANILFTQE 215
Query: 232 LQYEYASKGIFVQSLIPFYVATSMTAPSNFLHRCSWL 268
L G+ S+ P V + + S+F+ WL
Sbjct: 216 LARRLKGSGVTTYSVHPGTVQSELVRHSSFMRWMWWL 252
>gi|40254992 carbonic reductase 4 [Homo sapiens]
Length = 237
Score = 62.0 bits (149), Expect = 7e-10
Identities = 51/186 (27%), Positives = 85/186 (45%), Gaps = 7/186 (3%)
Query: 72 VSGATDGIGKAYAEELASRGLNIILISRNEEKLQVVAKDIADTYKVETDIIVADFSSGRE 131
V G + GIG+A A+ +A +G + +I+RN E + A D+ + + D + +
Sbjct: 7 VFGGSRGIGRAVAQLMARKGYRLAVIARNLEGAKAAAGDLGGDHLAFS----CDVAKEHD 62
Query: 132 IYLPIREALKDKD-VGILVNNVGVFYPYPQYFTQLSEDKLWDIINVNIAAASLMVHVVLP 190
+ E K V LVN G+ + + + ++ N+ + L +
Sbjct: 63 VQNTFEELEKHLGRVNFLVNAAGI--NRDGLLVRTKTEDMVSQLHTNLLGSMLTCKAAMR 120
Query: 191 GMVERKKGAIVTISSGSCCKPTPQLAAFSASKAYLDHFSRALQYEYASKGIFVQSLIPFY 250
M++++ G+IV + S K + +SASK L FSRAL E A K I V + P +
Sbjct: 121 TMIQQQGGSIVNVGSIVGLKGNSGQSVYSASKGGLVGFSRALAKEVARKKIRVNVVAPGF 180
Query: 251 VATSMT 256
V T MT
Sbjct: 181 VHTDMT 186
>gi|225579078 retinol dehydrogenase 13 isoform 1 [Homo sapiens]
Length = 331
Score = 59.3 bits (142), Expect = 5e-09
Identities = 70/237 (29%), Positives = 101/237 (42%), Gaps = 33/237 (13%)
Query: 67 GRWAVVSGATDGIGKAYAEELASRGLNIILISRNEEKLQVVAKDI-ADTYKVETD---II 122
G+ +V+GA GIGK A ELA RG NIIL R+ EK + AKDI +T + +
Sbjct: 38 GKTVIVTGANTGIGKQTALELARRGGNIILACRDMEKCEAAAKDIRGETLNHHVNARHLD 97
Query: 123 VADFSSGREIYLPIREALKDKDVGILVNNVGVFYPYPQYFTQLSEDKLWDIINVNIAAAS 182
+A S RE I E +++ V IL+NN GV P + T ED VN
Sbjct: 98 LASLKSIREFAAKIIE--EEERVDILINNAGVM-RCPHWTT---EDGFEMQFGVNHLGHF 151
Query: 183 LMVHVVLPGMVERKKGAIVTISS-------------GSCCKPTPQLAAFSASKAYLDHFS 229
L+ +++L + I+ +SS + AA+ SK + F+
Sbjct: 152 LLTNLLLDKLKASAPSRIINLSSLAHVAGHIDFDDLNWQTRKYNTKAAYCQSKLAIVLFT 211
Query: 230 RALQYEYASKGIFVQSLIPFYVATSM---------TAPSNFLHRCSW-LVPSPKVYA 276
+ L G+ V +L P T + T S L W LV SP++ A
Sbjct: 212 KELSRRLQGSGVTVNALHPGVARTELGRHTGIHGSTFSSTTLGPIFWLLVKSPELAA 268
>gi|150247226 retinol dehydrogenase 16 [Homo sapiens]
Length = 317
Score = 59.3 bits (142), Expect = 5e-09
Identities = 51/198 (25%), Positives = 97/198 (48%), Gaps = 10/198 (5%)
Query: 68 RWAVVSGATDGIGKAYAEELASRGLNII---LISRNEEKLQVVAKDIADTYKVETDIIVA 124
++ ++G G GK A +L +RGL ++ L + E+L+ D +T V D+
Sbjct: 30 KYVFITGCDSGFGKLLARQLDARGLRVLAACLTEKGAEQLRGQTSDRLET--VTLDVTKT 87
Query: 125 DFSSGREIYLPIREALKDKDVGILVNNVGVFYPYPQYFTQLSEDKLWDIINVNIAAASLM 184
+ + + ++E ++DK + LVNN G+ P L++ I++VN+ +
Sbjct: 88 ESVAAAAQW--VKECVRDKGLWGLVNNAGISLPTAPN-ELLTKQDFVTILDVNLLGVIDV 144
Query: 185 VHVVLPGMVERKKGAIVTISSGSCCKPTPQLAAFSASKAYLDHFSRALQYEYASKGIFVQ 244
+LP +V R +G +V +SS + + + SK ++ FS +L+ E + G+ V
Sbjct: 145 TLSLLP-LVRRARGRVVNVSS-VMGRVSLFGGGYCISKYGVEAFSDSLRRELSYFGVKVA 202
Query: 245 SLIPFYVATSMTAPSNFL 262
+ P Y T++T+ FL
Sbjct: 203 MIEPGYFKTAVTSKERFL 220
>gi|44680136 3-hydroxybutyrate dehydrogenase, type 1 precursor [Homo
sapiens]
Length = 343
Score = 58.9 bits (141), Expect = 6e-09
Identities = 65/231 (28%), Positives = 102/231 (44%), Gaps = 38/231 (16%)
Query: 52 FIPRLGSR--ADLIKQYGRWAV-VSGATDGIGKAYAEELASRGLNII------------- 95
FIP +G R A + G AV V+G G G + A+ L S+G +
Sbjct: 38 FIP-IGRRTYASAAEPVGSKAVLVTGCDSGFGFSLAKHLHSKGFLVFAGCLMKDKGHDGV 96
Query: 96 --LISRNEEKLQVVAKDIADTYKVETDIIVADFSSGREIYLPIREALKDKDVGI--LVNN 151
L S N ++L+ V ++ + +VE + + +R +LKD + G+ LVNN
Sbjct: 97 KELDSLNSDRLRTVQLNVCSSEEVEKVVEI------------VRSSLKDPEKGMWGLVNN 144
Query: 152 VGVFYPYPQYFTQLSEDKLWDIINVNIAAASLMVHVVLPGMVERKKGAIVTISSGSCCKP 211
G+ FT L K + VN+ M LP ++ R KG +V ISS
Sbjct: 145 AGISTFGEVEFTSLETYK--QVAEVNLWGTVRMTKSFLP-LIRRAKGRVVNISSMLGRMA 201
Query: 212 TPQLAAFSASKAYLDHFSRALQYEYASKGIFVQSLIP--FYVATSMTAPSN 260
P + + +K ++ FS L+YE G+ V + P F ATS+ +P +
Sbjct: 202 NPARSPYCITKFGVEAFSDCLRYEMYPLGVKVSVVEPGNFIAATSLYSPES 252
>gi|44680133 3-hydroxybutyrate dehydrogenase, type 1 precursor [Homo
sapiens]
Length = 343
Score = 58.9 bits (141), Expect = 6e-09
Identities = 65/231 (28%), Positives = 102/231 (44%), Gaps = 38/231 (16%)
Query: 52 FIPRLGSR--ADLIKQYGRWAV-VSGATDGIGKAYAEELASRGLNII------------- 95
FIP +G R A + G AV V+G G G + A+ L S+G +
Sbjct: 38 FIP-IGRRTYASAAEPVGSKAVLVTGCDSGFGFSLAKHLHSKGFLVFAGCLMKDKGHDGV 96
Query: 96 --LISRNEEKLQVVAKDIADTYKVETDIIVADFSSGREIYLPIREALKDKDVGI--LVNN 151
L S N ++L+ V ++ + +VE + + +R +LKD + G+ LVNN
Sbjct: 97 KELDSLNSDRLRTVQLNVCSSEEVEKVVEI------------VRSSLKDPEKGMWGLVNN 144
Query: 152 VGVFYPYPQYFTQLSEDKLWDIINVNIAAASLMVHVVLPGMVERKKGAIVTISSGSCCKP 211
G+ FT L K + VN+ M LP ++ R KG +V ISS
Sbjct: 145 AGISTFGEVEFTSLETYK--QVAEVNLWGTVRMTKSFLP-LIRRAKGRVVNISSMLGRMA 201
Query: 212 TPQLAAFSASKAYLDHFSRALQYEYASKGIFVQSLIP--FYVATSMTAPSN 260
P + + +K ++ FS L+YE G+ V + P F ATS+ +P +
Sbjct: 202 NPARSPYCITKFGVEAFSDCLRYEMYPLGVKVSVVEPGNFIAATSLYSPES 252
>gi|17738292 3-hydroxybutyrate dehydrogenase, type 1 precursor [Homo
sapiens]
Length = 343
Score = 58.9 bits (141), Expect = 6e-09
Identities = 65/231 (28%), Positives = 102/231 (44%), Gaps = 38/231 (16%)
Query: 52 FIPRLGSR--ADLIKQYGRWAV-VSGATDGIGKAYAEELASRGLNII------------- 95
FIP +G R A + G AV V+G G G + A+ L S+G +
Sbjct: 38 FIP-IGRRTYASAAEPVGSKAVLVTGCDSGFGFSLAKHLHSKGFLVFAGCLMKDKGHDGV 96
Query: 96 --LISRNEEKLQVVAKDIADTYKVETDIIVADFSSGREIYLPIREALKDKDVGI--LVNN 151
L S N ++L+ V ++ + +VE + + +R +LKD + G+ LVNN
Sbjct: 97 KELDSLNSDRLRTVQLNVCSSEEVEKVVEI------------VRSSLKDPEKGMWGLVNN 144
Query: 152 VGVFYPYPQYFTQLSEDKLWDIINVNIAAASLMVHVVLPGMVERKKGAIVTISSGSCCKP 211
G+ FT L K + VN+ M LP ++ R KG +V ISS
Sbjct: 145 AGISTFGEVEFTSLETYK--QVAEVNLWGTVRMTKSFLP-LIRRAKGRVVNISSMLGRMA 201
Query: 212 TPQLAAFSASKAYLDHFSRALQYEYASKGIFVQSLIP--FYVATSMTAPSN 260
P + + +K ++ FS L+YE G+ V + P F ATS+ +P +
Sbjct: 202 NPARSPYCITKFGVEAFSDCLRYEMYPLGVKVSVVEPGNFIAATSLYSPES 252
>gi|31543615 dehydrogenase/reductase (SDR family) member 3 [Homo
sapiens]
Length = 302
Score = 58.2 bits (139), Expect = 1e-08
Identities = 50/189 (26%), Positives = 84/189 (44%), Gaps = 8/189 (4%)
Query: 71 VVSGATDGIGKAYAEELASRGL-NIILISRNEEKLQVVAKDIADTYKVETDIIVADFSSG 129
+++G GIG+ A E A RG I+L R E+ L+ ++I E + D +
Sbjct: 42 LITGGGRGIGRQLAREFAERGARKIVLWGRTEKCLKETTEEIRQ-MGTECHYFICDVGNR 100
Query: 130 REIYLPIREALKDK--DVGILVNNVGVFYPYPQYFTQLSEDKLWDIINVNIAAASLMVHV 187
E+Y +A+++K D+ ILVNN V + + +D L ++N
Sbjct: 101 EEVY-QTAKAVREKVGDITILVNNAAVV--HGKSLMDSDDDALLKSQHINTLGQFWTTKA 157
Query: 188 VLPGMVERKKGAIVTISSGSCCKPTPQLAAFSASKAYLDHFSRALQYEYAS-KGIFVQSL 246
LP M+E + G IV ++S P + SKA F +L G+ ++
Sbjct: 158 FLPRMLELQNGHIVCLNSVLALSAIPGAIDYCTSKASAFAFMESLTLGLLDCPGVSATTV 217
Query: 247 IPFYVATSM 255
+PF+ +T M
Sbjct: 218 LPFHTSTEM 226
>gi|40807363 epidermal retinal dehydrogenase 2 [Homo sapiens]
Length = 309
Score = 57.8 bits (138), Expect = 1e-08
Identities = 49/193 (25%), Positives = 80/193 (41%), Gaps = 6/193 (3%)
Query: 67 GRWAVVSGATDGIGKAYAEELASRGLNIILISRNEEKLQVVAKDIADTYKVETDIIVADF 126
G +++GA G+G+ A + A G ++L N+E + K + D
Sbjct: 40 GEIVLITGAGSGLGRLLALQFARLGSVLVLWDINKEGNEETCKMAREAGATRVHAYTCDC 99
Query: 127 SSGREIYLPIREALKD-KDVGILVNNVGVFYPYPQYFTQLSEDKLWDIINVNIAAASLMV 185
S +Y + K+ DV IL+NN G+ + F ++ + +VN A
Sbjct: 100 SQKEGVYRVADQVKKEVGDVSILINNAGIV--TGKKFLDCPDELMEKSFDVNFKAHLWTY 157
Query: 186 HVVLPGMVERKKGAIVTISSGSCCKPTPQLAAFSASKAYLDHFSRALQYE---YASKGIF 242
LP M+ G +V ISS + LA + ASK F+ ++ E KGI
Sbjct: 158 KAFLPAMIANDHGHLVCISSSAGLSGVNGLADYCASKFAAFGFAESVFVETFVQKQKGIK 217
Query: 243 VQSLIPFYVATSM 255
+ PF++ T M
Sbjct: 218 TTIVCPFFIKTGM 230
>gi|4503817 3-ketodihydrosphingosine reductase precursor [Homo
sapiens]
Length = 332
Score = 57.4 bits (137), Expect = 2e-08
Identities = 49/187 (26%), Positives = 80/187 (42%), Gaps = 7/187 (3%)
Query: 67 GRWAVVSGATDGIGKAYAEELASRGLNIILISRNEEKLQVVAKDIADTYKVETDIIVADF 126
G VV+G + GIGK A E +G I L++RNE+KL K+I + +++
Sbjct: 32 GAHVVVTGGSSGIGKCIAIECYKQGAFITLVARNEDKLLQAKKEIEMHSINDKQVVLCIS 91
Query: 127 SSGREIYLPIREALKDKD-----VGILVNNVGVFYPYPQYFTQLSEDKLWDIINVNIAAA 181
+ Y + +K V +LVN G+ F L ++++N +
Sbjct: 92 VDVSQDYNQVENVIKQAQEKLGPVDMLVNCAGM--AVSGKFEDLEVSTFERLMSINYLGS 149
Query: 182 SLMVHVVLPGMVERKKGAIVTISSGSCCKPTPQLAAFSASKAYLDHFSRALQYEYASKGI 241
V+ M ER+ G IV +SS + A+SASK + + ALQ E +
Sbjct: 150 VYPSRAVITTMKERRVGRIVFVSSQAGQLGLFGFTAYSASKFAIRGLAEALQMEVKPYNV 209
Query: 242 FVQSLIP 248
++ P
Sbjct: 210 YITVAYP 216
>gi|22507405 short chain dehydrogenase/reductase family 9C, member 7
[Homo sapiens]
Length = 313
Score = 57.4 bits (137), Expect = 2e-08
Identities = 56/222 (25%), Positives = 106/222 (47%), Gaps = 9/222 (4%)
Query: 46 SLIRLHFIPRLGSRADLIKQYG-RWAVVSGATDGIGKAYAEELASRGLNIILISRNEEKL 104
+L L F+ R +L+ ++ ++G G G A++L RG+ ++ EE
Sbjct: 3 ALTDLSFMYRWFKNCNLVGNLSEKYVFITGCDSGFGNLLAKQLVDRGMQVLAACFTEEGS 62
Query: 105 QVVAKDIADTYKVETDII-VADFSSGREIYLPIREALKDKDVGILVNNVGVFYPY-PQYF 162
Q + +D +Y+++T ++ V S + +R+ + ++ + LVNN GV P P +
Sbjct: 63 QKLQRD--TSYRLQTTLLDVTKSESIKAAAQWVRDKVGEQGLWALVNNAGVGLPSGPNEW 120
Query: 163 TQLSEDKLWDIINVNIAAASLMVHVVLPGMVERKKGAIVTISSGSCCKPTPQLAAFSASK 222
L++D +INVN+ + +LP MV+R +G +V +SS S + + SK
Sbjct: 121 --LTKDDFVKVINVNLVGLIEVTLHMLP-MVKRARGRVVNMSS-SGGRVAVIGGGYCVSK 176
Query: 223 AYLDHFSRALQYEYASKGIFVQSLIPFYVATSMTAPSNFLHR 264
++ FS +++ E G+ V + P T++ N R
Sbjct: 177 FGVEAFSDSIRRELYYFGVKVCIIEPGNYRTAILGKENLESR 218
>gi|126723750 dehydrogenase/reductase (SDR family) member 4 like 1
[Homo sapiens]
Length = 281
Score = 57.0 bits (136), Expect = 2e-08
Identities = 46/194 (23%), Positives = 92/194 (47%), Gaps = 12/194 (6%)
Query: 70 AVVSGATDGIGKAYAEELASRGLNIILISRNEEKLQVVAKDIADTYKVETDII-----VA 124
A+V+ +TD IG A A+ LA G ++++ R ++ + + T + +
Sbjct: 35 ALVTASTDWIGFAVAQRLAQDGAHVVVSRRKQQNVDQAVATLQGEGLSMTGTVCHVGKMK 94
Query: 125 DFSSGREIYLPIREALKDKDVGILVNNVGVFYPYPQYFTQL-SEDKLWDI-INVNIAAAS 182
D+ + + + + I + G+F+ FT L + ++ WD +++N A +
Sbjct: 95 DWERLVATAMKLHGVIDILSLSITNSKRGLFW-----FTLLQTAEEAWDRNLDINGKALA 149
Query: 183 LMVHVVLPGMVERKKGAIVTISSGSCCKPTPQLAAFSASKAYLDHFSRALQYEYASKGIF 242
LM+ V+P M +R G++ ++S + +P P + ++ SK L ++ L E A + I
Sbjct: 150 LMIKAVVPEMEKRGGGSVGFLASVAAFRPLPGFSPYNVSKTALLGLNKTLAIELAPRNIR 209
Query: 243 VQSLIPFYVATSMT 256
V L P + TS +
Sbjct: 210 VNCLAPGLIKTSFS 223
>gi|7705925 dicarbonyl/L-xylulose reductase [Homo sapiens]
Length = 244
Score = 56.6 bits (135), Expect = 3e-08
Identities = 48/190 (25%), Positives = 85/190 (44%), Gaps = 11/190 (5%)
Query: 67 GRWAVVSGATDGIGKAYAEELASRGLNIILISRNEEKLQVVAKDIADTYKVETDIIVADF 126
GR +V+GA GIG+ + L + G ++ +SR + L + ++ V D+ D+
Sbjct: 7 GRRVLVTGAGKGIGRGTVQALHATGARVVAVSRTQADLDSLVRECPGIEPVCVDL--GDW 64
Query: 127 SSGREIYLPIREALKDKDVGILVNNVGVFYPYPQYFTQLSEDKLWDIINVNIAAASLMVH 186
+ R V +LVNN V P F +++++ VN+ A +
Sbjct: 65 EATE------RALGSVGPVDLLVNNAAVALLQP--FLEVTKEAFDRSFEVNLRAVIQVSQ 116
Query: 187 VVLPGMVER-KKGAIVTISSGSCCKPTPQLAAFSASKAYLDHFSRALQYEYASKGIFVQS 245
+V G++ R GAIV +SS + + + ++K LD ++ + E I V +
Sbjct: 117 IVARGLIARGVPGAIVNVSSQCSQRAVTNHSVYCSTKGALDMLTKVMALELGPHKIRVNA 176
Query: 246 LIPFYVATSM 255
+ P V TSM
Sbjct: 177 VNPTVVMTSM 186
>gi|66933014 3-hydroxybutyrate dehydrogenase, type 2 [Homo sapiens]
Length = 245
Score = 56.2 bits (134), Expect = 4e-08
Identities = 51/190 (26%), Positives = 91/190 (47%), Gaps = 16/190 (8%)
Query: 67 GRWAVVSGATDGIGKAYAEELASRGLNIILISRNEEKLQVVAKDIADTYKVETDIIVADF 126
G+ +++ A GIG+A A A G +I NE KLQ + K ++T ++ D
Sbjct: 6 GKVIILTAAAQGIGQAAALAFAREGAKVIATDINESKLQELEKYPG----IQTRVL--DV 59
Query: 127 SSGREIYLPIREALKDKDVGILVNNVGVFYPYPQYFTQLS-EDKLWDI-INVNIAAASLM 184
+ ++I E + + +L N G + + T L E+K WD +N+N+ + LM
Sbjct: 60 TKKKQIDQFANEV---ERLDVLFNVAG----FVHHGTVLDCEEKDWDFSMNLNVRSMYLM 112
Query: 185 VHVVLPGMVERKKGAIVTISS-GSCCKPTPQLAAFSASKAYLDHFSRALQYEYASKGIFV 243
+ LP M+ +K G I+ +SS S K +S +KA + ++++ ++ +GI
Sbjct: 113 IKAFLPKMLAQKSGNIINMSSVASSVKGVVNRCVYSTTKAAVIGLTKSVAADFIQQGIRC 172
Query: 244 QSLIPFYVAT 253
+ P V T
Sbjct: 173 NCVCPGTVDT 182
>gi|32455239 11-beta-hydroxysteroid dehydrogenase 1 [Homo sapiens]
Length = 292
Score = 55.8 bits (133), Expect = 5e-08
Identities = 52/209 (24%), Positives = 95/209 (45%), Gaps = 22/209 (10%)
Query: 67 GRWAVVSGATDGIGKAYAEELASRGLNIILISRNEEKLQVVAKDIADTYKVETDII---V 123
G+ +V+GA+ GIG+ A LA G ++++ +R++E LQ V + I +
Sbjct: 34 GKKVIVTGASKGIGREMAYHLAKMGAHVVVTARSKETLQKVVSHCLELGAASAHYIAGTM 93
Query: 124 ADFSSGREIYLPIREALKDKDVGIL--VNNVGVFYPYPQYFTQLSEDKLWDI---INVNI 178
D + + + + D+ IL + N + L D + + + VN
Sbjct: 94 EDMTFAEQFVAQAGKLMGGLDMLILNHITNTSL---------NLFHDDIHHVRKSMEVNF 144
Query: 179 AAASLMVHVVLPGMVERKKGAIVTISSGSCCKPTPQLAAFSASKAYLDHFSRALQYEYAS 238
+ ++ LP M+++ G+IV +SS + P +AA+SASK LD F +++ EY+
Sbjct: 145 LSYVVLTVAALP-MLKQSNGSIVVVSSLAGKVAYPMVAAYSASKFALDGFFSSIRKEYSV 203
Query: 239 KGIFVQSLIPFY----VATSMTAPSNFLH 263
+ V + T+M A S +H
Sbjct: 204 SRVNVSITLCVLGLIDTETAMKAVSGIVH 232
>gi|5031765 11-beta-hydroxysteroid dehydrogenase 1 [Homo sapiens]
Length = 292
Score = 55.8 bits (133), Expect = 5e-08
Identities = 52/209 (24%), Positives = 95/209 (45%), Gaps = 22/209 (10%)
Query: 67 GRWAVVSGATDGIGKAYAEELASRGLNIILISRNEEKLQVVAKDIADTYKVETDII---V 123
G+ +V+GA+ GIG+ A LA G ++++ +R++E LQ V + I +
Sbjct: 34 GKKVIVTGASKGIGREMAYHLAKMGAHVVVTARSKETLQKVVSHCLELGAASAHYIAGTM 93
Query: 124 ADFSSGREIYLPIREALKDKDVGIL--VNNVGVFYPYPQYFTQLSEDKLWDI---INVNI 178
D + + + + D+ IL + N + L D + + + VN
Sbjct: 94 EDMTFAEQFVAQAGKLMGGLDMLILNHITNTSL---------NLFHDDIHHVRKSMEVNF 144
Query: 179 AAASLMVHVVLPGMVERKKGAIVTISSGSCCKPTPQLAAFSASKAYLDHFSRALQYEYAS 238
+ ++ LP M+++ G+IV +SS + P +AA+SASK LD F +++ EY+
Sbjct: 145 LSYVVLTVAALP-MLKQSNGSIVVVSSLAGKVAYPMVAAYSASKFALDGFFSSIRKEYSV 203
Query: 239 KGIFVQSLIPFY----VATSMTAPSNFLH 263
+ V + T+M A S +H
Sbjct: 204 SRVNVSITLCVLGLIDTETAMKAVSGIVH 232
>gi|19743808 hydroxysteroid (17-beta) dehydrogenase 6 [Homo sapiens]
Length = 317
Score = 55.5 bits (132), Expect = 7e-08
Identities = 50/202 (24%), Positives = 91/202 (45%), Gaps = 6/202 (2%)
Query: 68 RWAVVSGATDGIGKAYAEELASRGLNIILISRNEEKLQVVAKDIADTYKVETDIIVADFS 127
++ ++G G G A +L +RGL ++ E+ + + +D + T + V
Sbjct: 30 KYVFITGCDSGFGNLLARQLDARGLRVLAACLTEKGAEQLRGQTSDRLETVT-LDVTKME 88
Query: 128 SGREIYLPIREALKDKDVGILVNNVGVFYPYPQYFTQLSEDKLWDIINVNIAAASLMVHV 187
S ++E + D+ + LVNN G+ P +ED + +++ VN+ +
Sbjct: 89 SIAAATQWVKEHVGDRGLWGLVNNAGILTPITLCEWLNTEDSM-NMLKVNLIGVIQVTLS 147
Query: 188 VLPGMVERKKGAIVTISSGSCCKPTPQLAAFSASKAYLDHFSRALQYEYASKGIFVQSLI 247
+LP +V R +G IV +SS + + + SK ++ FS L+ E G+ + +
Sbjct: 148 MLP-LVRRARGRIVNVSS-ILGRVAFFVGGYCVSKYGVEAFSDILRREIQHFGVKISIVE 205
Query: 248 PFYVATSMTAPSNFLHRC--SW 267
P Y T MT + L R SW
Sbjct: 206 PGYFRTGMTNMTQSLERMKQSW 227
>gi|193804850 dehydrogenase/reductase (SDR family) X-linked [Homo
sapiens]
Length = 330
Score = 55.1 bits (131), Expect = 9e-08
Identities = 55/197 (27%), Positives = 93/197 (47%), Gaps = 28/197 (14%)
Query: 68 RWAVVSGATDGIGKAYAEELASRGLNIILISRNEEKL-QVVAKDIADTYKVETDIIVADF 126
R A+V+G TDGIG + A+ LA G+++I+ N+ K QVV+K +T + + + D
Sbjct: 44 RVAIVTGGTDGIGYSTAKHLARLGMHVIIAGNNDSKAKQVVSKIKEETLNDKVEFLYCDL 103
Query: 127 SSGREIYLPIRE-ALKDKDVGILVNNVGVFYPYPQYFTQLSEDKLWDIINVNIAAASLMV 185
+S I +++ +K + +L+NN GV PQ T+ D + +N L+
Sbjct: 104 ASMTSIRQFVQKFKMKKIPLHVLINNAGVMM-VPQRKTR---DGFEEHFGLNYLGHFLLT 159
Query: 186 HVVLPGMVER----KKGAIVTIS---------------SGSCCKPTPQLAAFSASKAYLD 226
+++L + E +VT+S S +C P AA++ SK L
Sbjct: 160 NLLLDTLKESGSPGHSARVVTVSSATHYVAELNMDDLQSSACYSPH---AAYAQSKLALV 216
Query: 227 HFSRALQYEYASKGIFV 243
F+ LQ A++G V
Sbjct: 217 LFTYHLQRLLAAEGSHV 233
Database: hs.faa
Posted date: Aug 4, 2009 4:42 PM
Number of letters in database: 18,247,518
Number of sequences in database: 37,866
Lambda K H
0.323 0.135 0.416
Gapped
Lambda K H
0.267 0.0410 0.140
Matrix: BLOSUM62
Gap Penalties: Existence: 11, Extension: 1
Number of Hits to DB: 11,312,492
Number of Sequences: 37866
Number of extensions: 454093
Number of successful extensions: 1226
Number of sequences better than 10.0: 30
Number of HSP's better than 10.0 without gapping: 45
Number of HSP's successfully gapped in prelim test: 20
Number of HSP's that attempted gapping in prelim test: 1130
Number of HSP's gapped (non-prelim): 67
length of query: 330
length of database: 18,247,518
effective HSP length: 103
effective length of query: 227
effective length of database: 14,347,320
effective search space: 3256841640
effective search space used: 3256841640
T: 11
A: 40
X1: 16 ( 7.5 bits)
X2: 38 (14.6 bits)
X3: 64 (24.7 bits)
S1: 40 (21.5 bits)
S2: 62 (28.5 bits)
Search results were obtained with NCBI BLAST and RefSeq entries.
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Guide to the Human Genome
Copyright © 2010 by Stewart Scherer. All rights reserved.