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Search of human proteins with 225903437
BLASTP 2.2.11 [Jun-05-2005]
Reference: Altschul, Stephen F., Thomas L. Madden, Alejandro A. Schaffer,
Jinghui Zhang, Zheng Zhang, Webb Miller, and David J. Lipman (1997),
"Gapped BLAST and PSI-BLAST: a new generation of protein database search
programs", Nucleic Acids Res. 25:3389-3402.
Query= gi|225903437 glycogen synthase kinase 3 beta isoform 2 [Homo
sapiens]
(420 letters)
Database: hs.faa
37,866 sequences; 18,247,518 total letters
Searching..................................................done
Score E
Sequences producing significant alignments: (bits) Value
gi|225903437 glycogen synthase kinase 3 beta isoform 2 [Homo sap... 849 0.0
gi|21361340 glycogen synthase kinase 3 beta isoform 1 [Homo sapi... 840 0.0
gi|49574532 glycogen synthase kinase 3 alpha [Homo sapiens] 629 e-180
gi|11496279 male germ cell-associated kinase [Homo sapiens] 179 4e-45
gi|91718897 mitogen-activated protein kinase 3 isoform 2 [Homo s... 174 1e-43
gi|91718899 mitogen-activated protein kinase 3 isoform 1 [Homo s... 174 1e-43
gi|27477122 intestinal cell kinase [Homo sapiens] 174 2e-43
gi|7662388 intestinal cell kinase [Homo sapiens] 174 2e-43
gi|4557439 cyclin-dependent kinase 3 [Homo sapiens] 173 3e-43
gi|4502743 cyclin-dependent kinase 7 [Homo sapiens] 172 4e-43
gi|4505569 cyclin-dependent kinase-like 2 [Homo sapiens] 172 4e-43
gi|16936528 cyclin-dependent kinase 2 isoform 1 [Homo sapiens] 170 3e-42
gi|37596297 cyclin-dependent kinase-like 1 [Homo sapiens] 169 4e-42
gi|20986497 mitogen-activated protein kinase 7 isoform 1 [Homo s... 166 4e-41
gi|209529736 mitogen-activated protein kinase 7 isoform 1 [Homo ... 166 4e-41
gi|209529734 mitogen-activated protein kinase 7 isoform 1 [Homo ... 166 4e-41
gi|4506085 mitogen-activated protein kinase 13 [Homo sapiens] 166 5e-41
gi|57222269 cyclin-dependent kinase-like 4 [Homo sapiens] 165 8e-41
gi|20986531 mitogen-activated protein kinase 1 [Homo sapiens] 164 2e-40
gi|66932916 mitogen-activated protein kinase 1 [Homo sapiens] 164 2e-40
gi|83367069 cyclin-dependent kinase-like 5 [Homo sapiens] 160 2e-39
gi|4507281 cyclin-dependent kinase-like 5 [Homo sapiens] 160 2e-39
gi|89903018 cell cycle related kinase isoform 3 [Homo sapiens] 160 2e-39
gi|21040235 PFTAIRE protein kinase 2 [Homo sapiens] 159 4e-39
gi|197333744 PCTAIRE protein kinase 1 isoform 2 [Homo sapiens] 158 1e-38
gi|5453860 PCTAIRE protein kinase 1 isoform 1 [Homo sapiens] 158 1e-38
gi|4826675 cyclin-dependent kinase 5 [Homo sapiens] 157 1e-38
gi|20128774 mitogen-activated protein kinase 11 [Homo sapiens] 157 1e-38
gi|48255970 mitogen-activated protein kinase 12 [Homo sapiens] 157 2e-38
gi|95147356 mitogen-activated protein kinase 15 [Homo sapiens] 155 5e-38
>gi|225903437 glycogen synthase kinase 3 beta isoform 2 [Homo
sapiens]
Length = 420
Score = 849 bits (2194), Expect = 0.0
Identities = 420/420 (100%), Positives = 420/420 (100%)
Query: 1 MSGRPRTTSFAESCKPVQQPSAFGSMKVSRDKDGSKVTTVVATPGQGPDRPQEVSYTDTK 60
MSGRPRTTSFAESCKPVQQPSAFGSMKVSRDKDGSKVTTVVATPGQGPDRPQEVSYTDTK
Sbjct: 1 MSGRPRTTSFAESCKPVQQPSAFGSMKVSRDKDGSKVTTVVATPGQGPDRPQEVSYTDTK 60
Query: 61 VIGNGSFGVVYQAKLCDSGELVAIKKVLQDKRFKNRELQIMRKLDHCNIVRLRYFFYSSG 120
VIGNGSFGVVYQAKLCDSGELVAIKKVLQDKRFKNRELQIMRKLDHCNIVRLRYFFYSSG
Sbjct: 61 VIGNGSFGVVYQAKLCDSGELVAIKKVLQDKRFKNRELQIMRKLDHCNIVRLRYFFYSSG 120
Query: 121 EKKDEVYLNLVLDYVPETVYRVARHYSRAKQTLPVIYVKLYMYQLFRSLAYIHSFGICHR 180
EKKDEVYLNLVLDYVPETVYRVARHYSRAKQTLPVIYVKLYMYQLFRSLAYIHSFGICHR
Sbjct: 121 EKKDEVYLNLVLDYVPETVYRVARHYSRAKQTLPVIYVKLYMYQLFRSLAYIHSFGICHR 180
Query: 181 DIKPQNLLLDPDTAVLKLCDFGSAKQLVRGEPNVSYICSRYYRAPELIFGATDYTSSIDV 240
DIKPQNLLLDPDTAVLKLCDFGSAKQLVRGEPNVSYICSRYYRAPELIFGATDYTSSIDV
Sbjct: 181 DIKPQNLLLDPDTAVLKLCDFGSAKQLVRGEPNVSYICSRYYRAPELIFGATDYTSSIDV 240
Query: 241 WSAGCVLAELLLGQPIFPGDSGVDQLVEIIKVLGTPTREQIREMNPNYTEFKFPQIKAHP 300
WSAGCVLAELLLGQPIFPGDSGVDQLVEIIKVLGTPTREQIREMNPNYTEFKFPQIKAHP
Sbjct: 241 WSAGCVLAELLLGQPIFPGDSGVDQLVEIIKVLGTPTREQIREMNPNYTEFKFPQIKAHP 300
Query: 301 WTKVFRPRTPPEAIALCSRLLEYTPTARLTPLEACAHSFFDELRDPNVKLPNGRDTPALF 360
WTKVFRPRTPPEAIALCSRLLEYTPTARLTPLEACAHSFFDELRDPNVKLPNGRDTPALF
Sbjct: 301 WTKVFRPRTPPEAIALCSRLLEYTPTARLTPLEACAHSFFDELRDPNVKLPNGRDTPALF 360
Query: 361 NFTTQELSSNPPLATILIPPHARIQAAASTPTNATAASDANTGDRGQTNNAASASASNST 420
NFTTQELSSNPPLATILIPPHARIQAAASTPTNATAASDANTGDRGQTNNAASASASNST
Sbjct: 361 NFTTQELSSNPPLATILIPPHARIQAAASTPTNATAASDANTGDRGQTNNAASASASNST 420
>gi|21361340 glycogen synthase kinase 3 beta isoform 1 [Homo
sapiens]
Length = 433
Score = 840 bits (2170), Expect = 0.0
Identities = 420/433 (96%), Positives = 420/433 (96%), Gaps = 13/433 (3%)
Query: 1 MSGRPRTTSFAESCKPVQQPSAFGSMKVSRDKDGSKVTTVVATPGQGPDRPQEVSYTDTK 60
MSGRPRTTSFAESCKPVQQPSAFGSMKVSRDKDGSKVTTVVATPGQGPDRPQEVSYTDTK
Sbjct: 1 MSGRPRTTSFAESCKPVQQPSAFGSMKVSRDKDGSKVTTVVATPGQGPDRPQEVSYTDTK 60
Query: 61 VIGNGSFGVVYQAKLCDSGELVAIKKVLQDKRFKNRELQIMRKLDHCNIVRLRYFFYSSG 120
VIGNGSFGVVYQAKLCDSGELVAIKKVLQDKRFKNRELQIMRKLDHCNIVRLRYFFYSSG
Sbjct: 61 VIGNGSFGVVYQAKLCDSGELVAIKKVLQDKRFKNRELQIMRKLDHCNIVRLRYFFYSSG 120
Query: 121 EKKDEVYLNLVLDYVPETVYRVARHYSRAKQTLPVIYVKLYMYQLFRSLAYIHSFGICHR 180
EKKDEVYLNLVLDYVPETVYRVARHYSRAKQTLPVIYVKLYMYQLFRSLAYIHSFGICHR
Sbjct: 121 EKKDEVYLNLVLDYVPETVYRVARHYSRAKQTLPVIYVKLYMYQLFRSLAYIHSFGICHR 180
Query: 181 DIKPQNLLLDPDTAVLKLCDFGSAKQLVRGEPNVSYICSRYYRAPELIFGATDYTSSIDV 240
DIKPQNLLLDPDTAVLKLCDFGSAKQLVRGEPNVSYICSRYYRAPELIFGATDYTSSIDV
Sbjct: 181 DIKPQNLLLDPDTAVLKLCDFGSAKQLVRGEPNVSYICSRYYRAPELIFGATDYTSSIDV 240
Query: 241 WSAGCVLAELLLGQPIFPGDSGVDQLVEIIKVLGTPTREQIREMNPNYTEFKFPQIKAHP 300
WSAGCVLAELLLGQPIFPGDSGVDQLVEIIKVLGTPTREQIREMNPNYTEFKFPQIKAHP
Sbjct: 241 WSAGCVLAELLLGQPIFPGDSGVDQLVEIIKVLGTPTREQIREMNPNYTEFKFPQIKAHP 300
Query: 301 WTK-------------VFRPRTPPEAIALCSRLLEYTPTARLTPLEACAHSFFDELRDPN 347
WTK VFRPRTPPEAIALCSRLLEYTPTARLTPLEACAHSFFDELRDPN
Sbjct: 301 WTKDSSGTGHFTSGVRVFRPRTPPEAIALCSRLLEYTPTARLTPLEACAHSFFDELRDPN 360
Query: 348 VKLPNGRDTPALFNFTTQELSSNPPLATILIPPHARIQAAASTPTNATAASDANTGDRGQ 407
VKLPNGRDTPALFNFTTQELSSNPPLATILIPPHARIQAAASTPTNATAASDANTGDRGQ
Sbjct: 361 VKLPNGRDTPALFNFTTQELSSNPPLATILIPPHARIQAAASTPTNATAASDANTGDRGQ 420
Query: 408 TNNAASASASNST 420
TNNAASASASNST
Sbjct: 421 TNNAASASASNST 433
>gi|49574532 glycogen synthase kinase 3 alpha [Homo sapiens]
Length = 483
Score = 629 bits (1622), Expect = e-180
Identities = 312/400 (78%), Positives = 346/400 (86%), Gaps = 1/400 (0%)
Query: 21 SAFGSMKVSRDKDGSKVTTVVATPGQGPDRPQEVSYTDTKVIGNGSFGVVYQAKLCDSGE 80
++F V +D KVTTVVAT GQGP+R QEV+YTD KVIGNGSFGVVYQA+L ++ E
Sbjct: 84 TSFPPPGVKLGRDSGKVTTVVATLGQGPERSQEVAYTDIKVIGNGSFGVVYQARLAETRE 143
Query: 81 LVAIKKVLQDKRFKNRELQIMRKLDHCNIVRLRYFFYSSGEKKDEVYLNLVLDYVPETVY 140
LVAIKKVLQDKRFKNRELQIMRKLDHCNIVRLRYFFYSSGEKKDE+YLNLVL+YVPETVY
Sbjct: 144 LVAIKKVLQDKRFKNRELQIMRKLDHCNIVRLRYFFYSSGEKKDELYLNLVLEYVPETVY 203
Query: 141 RVARHYSRAKQTLPVIYVKLYMYQLFRSLAYIHSFGICHRDIKPQNLLLDPDTAVLKLCD 200
RVARH+++AK T+P++YVK+YMYQLFRSLAYIHS G+CHRDIKPQNLL+DPDTAVLKLCD
Sbjct: 204 RVARHFTKAKLTIPILYVKVYMYQLFRSLAYIHSQGVCHRDIKPQNLLVDPDTAVLKLCD 263
Query: 201 FGSAKQLVRGEPNVSYICSRYYRAPELIFGATDYTSSIDVWSAGCVLAELLLGQPIFPGD 260
FGSAKQLVRGEPNVSYICSRYYRAPELIFGATDYTSSIDVWSAGCVLAELLLGQPIFPGD
Sbjct: 264 FGSAKQLVRGEPNVSYICSRYYRAPELIFGATDYTSSIDVWSAGCVLAELLLGQPIFPGD 323
Query: 261 SGVDQLVEIIKVLGTPTREQIREMNPNYTEFKFPQIKAHPWTKVFRPRTPPEAIALCSRL 320
SGVDQLVEIIKVLGTPTREQIREMNPNYTEFKFPQIKAHPWTKVF+ RTPPEAIALCS L
Sbjct: 324 SGVDQLVEIIKVLGTPTREQIREMNPNYTEFKFPQIKAHPWTKVFKSRTPPEAIALCSSL 383
Query: 321 LEYTPTARLTPLEACAHSFFDELRDPNVKLPNGRDTPALFNFTTQELSSNPPLATILIPP 380
LEYTP++RL+PLEACAHSFFDELR +LPN R P LFNF+ ELS P L ILIPP
Sbjct: 384 LEYTPSSRLSPLEACAHSFFDELRCLGTQLPNNRPLPPLFNFSAGELSIQPSLNAILIPP 443
Query: 381 HARIQAAASTPT-NATAASDANTGDRGQTNNAASASASNS 419
H R A +T T ++ A ++ T Q+ +A ++S
Sbjct: 444 HLRSPAGTTTLTPSSQALTETPTSSDWQSTDATPTLTNSS 483
>gi|11496279 male germ cell-associated kinase [Homo sapiens]
Length = 623
Score = 179 bits (454), Expect = 4e-45
Identities = 108/331 (32%), Positives = 185/331 (55%), Gaps = 25/331 (7%)
Query: 56 YTDTKVIGNGSFGVVYQAKLCDSGELVAIKKVLQ-----DKRFKNRELQIMRKLDHCNIV 110
YT + +G+G++G V K +SGELVAIK++ + D+ RE++ ++KL+H N++
Sbjct: 4 YTTMRQLGDGTYGSVLMGKSNESGELVAIKRMKRKFYSWDECMNLREVKSLKKLNHANVI 63
Query: 111 RLRYFFYSSGEKKDEVYLNLVLDYVPETVYRVARHYSRAKQTLPVIYVKLYMYQLFRSLA 170
+L+ ++ +L + +Y+ E +Y++ + ++ P ++ MYQ+ + LA
Sbjct: 64 KLKEVI------RENDHLYFIFEYMKENLYQLMKDRNKL---FPESVIRNIMYQILQGLA 114
Query: 171 YIHSFGICHRDIKPQNLL-LDPDTAVLKLCDFGSAKQLVRGEPNVSYICSRYYRAPELIF 229
+IH G HRD+KP+NLL + P+ ++K+ DFG A++L P Y+ +R+YRAPE++
Sbjct: 115 FIHKHGFFHRDMKPENLLCMGPE--LVKIADFGLARELRSQPPYTDYVSTRWYRAPEVLL 172
Query: 230 GATDYTSSIDVWSAGCVLAELLLGQPIFPGDSGVDQLVEIIKVLGTPTREQIRE--MNPN 287
++ Y+S IDVW+ G ++AEL + +P+FPG S VD++ +I +VLGTP + E +
Sbjct: 173 RSSVYSSPIDVWAVGSIMAELYMLRPLFPGTSEVDEIFKICQVLGTPKKSDWPEGYQLAS 232
Query: 288 YTEFKFPQIKAHPWTKVFRPRTPPEAIALCSRLLEYTPTARLTPLEACAHSFFD--ELRD 345
F+FPQ K P EAI L + +L + P R T +A H +F ++
Sbjct: 233 SMNFRFPQCVPIN-LKTLIPNASNEAIQLMTEMLNWDPKKRPTASQALKHPYFQVGQVLG 291
Query: 346 PNVKLPNGRDTPALFNFTTQELSSNPPLATI 376
P+ N ++ N Q L S P L +
Sbjct: 292 PS---SNHLESKQSLNKQLQPLESKPSLVEV 319
>gi|91718897 mitogen-activated protein kinase 3 isoform 2 [Homo
sapiens]
Length = 357
Score = 174 bits (441), Expect = 1e-43
Identities = 114/330 (34%), Positives = 176/330 (53%), Gaps = 36/330 (10%)
Query: 43 TPGQGPDRPQEVS------------YTDTKVIGNGSFGVVYQAKLCDSGELVAIKKV--L 88
T G GP P EV YT + IG G++G+V A VAIKK+
Sbjct: 17 TEGVGPGVPGEVEMVKGQPFDVGPRYTQLQYIGEGAYGMVSSAYDHVRKTRVAIKKISPF 76
Query: 89 QDKRFKNR---ELQIMRKLDHCNIVRLRYFFYSSG-EKKDEVYLNLVLDYVPETVYRVAR 144
+ + + R E+QI+ + H N++ +R +S E +VY+ V D + +Y++ +
Sbjct: 77 EHQTYCQRTLREIQILLRFRHENVIGIRDILRASTLEAMRDVYI--VQDLMETDLYKLLK 134
Query: 145 HYSRAKQTLPVIYVKLYMYQLFRSLAYIHSFGICHRDIKPQNLLLDPDTAVLKLCDFGSA 204
Q L ++ ++YQ+ R L YIHS + HRD+KP NLL++ T LK+CDFG A
Sbjct: 135 -----SQQLSNDHICYFLYQILRGLKYIHSANVLHRDLKPSNLLINT-TCDLKICDFGLA 188
Query: 205 KQLVRGEPNVS----YICSRYYRAPELIFGATDYTSSIDVWSAGCVLAELLLGQPIFPGD 260
+ + Y+ +R+YRAPE++ + YT SID+WS GC+LAE+L +PIFPG
Sbjct: 189 RIADPEHDHTGFLTEYVATRWYRAPEIMLNSKGYTKSIDIWSVGCILAEMLSNRPIFPGK 248
Query: 261 SGVDQLVEIIKVLGTPTREQ----IREMNPNYTEFKFPQIKAHPWTKVFRPRTPPEAIAL 316
+DQL I+ +LG+P++E I NY + P W K+F P++ +A+ L
Sbjct: 249 HYLDQLNHILGILGSPSQEDLNCIINMKARNYLQ-SLPSKTKVAWAKLF-PKSDSKALDL 306
Query: 317 CSRLLEYTPTARLTPLEACAHSFFDELRDP 346
R+L + P R+T EA AH + ++ DP
Sbjct: 307 LDRMLTFNPNKRITVEEALAHPYLEQYYDP 336
>gi|91718899 mitogen-activated protein kinase 3 isoform 1 [Homo
sapiens]
Length = 379
Score = 174 bits (441), Expect = 1e-43
Identities = 114/330 (34%), Positives = 176/330 (53%), Gaps = 36/330 (10%)
Query: 43 TPGQGPDRPQEVS------------YTDTKVIGNGSFGVVYQAKLCDSGELVAIKKV--L 88
T G GP P EV YT + IG G++G+V A VAIKK+
Sbjct: 17 TEGVGPGVPGEVEMVKGQPFDVGPRYTQLQYIGEGAYGMVSSAYDHVRKTRVAIKKISPF 76
Query: 89 QDKRFKNR---ELQIMRKLDHCNIVRLRYFFYSSG-EKKDEVYLNLVLDYVPETVYRVAR 144
+ + + R E+QI+ + H N++ +R +S E +VY+ V D + +Y++ +
Sbjct: 77 EHQTYCQRTLREIQILLRFRHENVIGIRDILRASTLEAMRDVYI--VQDLMETDLYKLLK 134
Query: 145 HYSRAKQTLPVIYVKLYMYQLFRSLAYIHSFGICHRDIKPQNLLLDPDTAVLKLCDFGSA 204
Q L ++ ++YQ+ R L YIHS + HRD+KP NLL++ T LK+CDFG A
Sbjct: 135 -----SQQLSNDHICYFLYQILRGLKYIHSANVLHRDLKPSNLLINT-TCDLKICDFGLA 188
Query: 205 KQLVRGEPNVS----YICSRYYRAPELIFGATDYTSSIDVWSAGCVLAELLLGQPIFPGD 260
+ + Y+ +R+YRAPE++ + YT SID+WS GC+LAE+L +PIFPG
Sbjct: 189 RIADPEHDHTGFLTEYVATRWYRAPEIMLNSKGYTKSIDIWSVGCILAEMLSNRPIFPGK 248
Query: 261 SGVDQLVEIIKVLGTPTREQ----IREMNPNYTEFKFPQIKAHPWTKVFRPRTPPEAIAL 316
+DQL I+ +LG+P++E I NY + P W K+F P++ +A+ L
Sbjct: 249 HYLDQLNHILGILGSPSQEDLNCIINMKARNYLQ-SLPSKTKVAWAKLF-PKSDSKALDL 306
Query: 317 CSRLLEYTPTARLTPLEACAHSFFDELRDP 346
R+L + P R+T EA AH + ++ DP
Sbjct: 307 LDRMLTFNPNKRITVEEALAHPYLEQYYDP 336
>gi|27477122 intestinal cell kinase [Homo sapiens]
Length = 632
Score = 174 bits (440), Expect = 2e-43
Identities = 95/293 (32%), Positives = 172/293 (58%), Gaps = 20/293 (6%)
Query: 56 YTDTKVIGNGSFGVVYQAKLCDSGELVAIKKVLQ-----DKRFKNRELQIMRKLDHCNIV 110
YT + +G+G++G V + +SGEL+AIKK+ + ++ RE++ ++KL+H N+V
Sbjct: 4 YTTIRQLGDGTYGSVLLGRSIESGELIAIKKMKRKFYSWEECMNLREVKSLKKLNHANVV 63
Query: 111 RLRYFFYSSGEKKDEVYLNLVLDYVPETVYRVARHYSRAKQTLPVIYVKLYMYQLFRSLA 170
+L+ ++ +L + +Y+ E +Y++ + ++ P ++ MYQ+ + LA
Sbjct: 64 KLKEVI------RENDHLYFIFEYMKENLYQLIKERNKL---FPESAIRNIMYQILQGLA 114
Query: 171 YIHSFGICHRDIKPQNLL-LDPDTAVLKLCDFGSAKQLVRGEPNVSYICSRYYRAPELIF 229
+IH G HRD+KP+NLL + P+ ++K+ DFG A+++ P Y+ +R+YRAPE++
Sbjct: 115 FIHKHGFFHRDLKPENLLCMGPE--LVKIADFGLAREIRSKPPYTDYVSTRWYRAPEVLL 172
Query: 230 GATDYTSSIDVWSAGCVLAELLLGQPIFPGDSGVDQLVEIIKVLGTPTREQIRE--MNPN 287
+T+Y+S IDVW+ GC++AE+ +P+FPG S +D + +I +VLGTP + E +
Sbjct: 173 RSTNYSSPIDVWAVGCIMAEVYTLRPLFPGASEIDTIFKICQVLGTPKKTDWPEGYQLSS 232
Query: 288 YTEFKFPQIKAHPWTKVFRPRTPPEAIALCSRLLEYTPTARLTPLEACAHSFF 340
F++PQ + K P EA+ L +L++ P R T +A + +F
Sbjct: 233 AMNFRWPQCVPNN-LKTLIPNASSEAVQLLRDMLQWDPKKRPTASQALRYPYF 284
>gi|7662388 intestinal cell kinase [Homo sapiens]
Length = 632
Score = 174 bits (440), Expect = 2e-43
Identities = 95/293 (32%), Positives = 172/293 (58%), Gaps = 20/293 (6%)
Query: 56 YTDTKVIGNGSFGVVYQAKLCDSGELVAIKKVLQ-----DKRFKNRELQIMRKLDHCNIV 110
YT + +G+G++G V + +SGEL+AIKK+ + ++ RE++ ++KL+H N+V
Sbjct: 4 YTTIRQLGDGTYGSVLLGRSIESGELIAIKKMKRKFYSWEECMNLREVKSLKKLNHANVV 63
Query: 111 RLRYFFYSSGEKKDEVYLNLVLDYVPETVYRVARHYSRAKQTLPVIYVKLYMYQLFRSLA 170
+L+ ++ +L + +Y+ E +Y++ + ++ P ++ MYQ+ + LA
Sbjct: 64 KLKEVI------RENDHLYFIFEYMKENLYQLIKERNKL---FPESAIRNIMYQILQGLA 114
Query: 171 YIHSFGICHRDIKPQNLL-LDPDTAVLKLCDFGSAKQLVRGEPNVSYICSRYYRAPELIF 229
+IH G HRD+KP+NLL + P+ ++K+ DFG A+++ P Y+ +R+YRAPE++
Sbjct: 115 FIHKHGFFHRDLKPENLLCMGPE--LVKIADFGLAREIRSKPPYTDYVSTRWYRAPEVLL 172
Query: 230 GATDYTSSIDVWSAGCVLAELLLGQPIFPGDSGVDQLVEIIKVLGTPTREQIRE--MNPN 287
+T+Y+S IDVW+ GC++AE+ +P+FPG S +D + +I +VLGTP + E +
Sbjct: 173 RSTNYSSPIDVWAVGCIMAEVYTLRPLFPGASEIDTIFKICQVLGTPKKTDWPEGYQLSS 232
Query: 288 YTEFKFPQIKAHPWTKVFRPRTPPEAIALCSRLLEYTPTARLTPLEACAHSFF 340
F++PQ + K P EA+ L +L++ P R T +A + +F
Sbjct: 233 AMNFRWPQCVPNN-LKTLIPNASSEAVQLLRDMLQWDPKKRPTASQALRYPYF 284
>gi|4557439 cyclin-dependent kinase 3 [Homo sapiens]
Length = 305
Score = 173 bits (438), Expect = 3e-43
Identities = 103/292 (35%), Positives = 170/292 (58%), Gaps = 28/292 (9%)
Query: 62 IGNGSFGVVYQAKLCDSGELVAIKKVLQDKRFKN------RELQIMRKLDHCNIVRLRYF 115
IG G++GVVY+AK ++G+LVA+KK+ D + RE+ ++++L H NIVRL
Sbjct: 10 IGEGTYGVVYKAKNRETGQLVALKKIRLDLEMEGVPSTAIREISLLKELKHPNIVRLLDV 69
Query: 116 FYSSGEKKDEVYLNLVLDYVPETVYRVARHYSRAKQTLPVIYVKLYMYQLFRSLAYIHSF 175
++ E+K L LV +++ + + + S LP+ +K Y++QL + +++ HS
Sbjct: 70 VHN--ERK----LYLVFEFLSQDLKKYMD--STPGSELPLHLIKSYLFQLLQGVSFCHSH 121
Query: 176 GICHRDIKPQNLLLDPDTAVLKLCDFGSAKQLVRGEPNVSY---ICSRYYRAPELIFGAT 232
+ HRD+KPQNLL++ + +KL DFG A+ G P +Y + + +YRAPE++ G+
Sbjct: 122 RVIHRDLKPQNLLIN-ELGAIKLADFGLARAF--GVPLRTYTHEVVTLWYRAPEILLGSK 178
Query: 233 DYTSSIDVWSAGCVLAELLLGQPIFPGDSGVDQLVEIIKVLGTPTREQIREMNPNYTEFK 292
YT+++D+WS GC+ AE++ + +FPGDS +DQL I ++LGTP+ + P T+
Sbjct: 179 FYTTAVDIWSIGCIFAEMVTRKALFPGDSEIDQLFRIFRMLGTPSEDTW----PGVTQLP 234
Query: 293 FPQIKAHPWTK----VFRPRTPPEAIALCSRLLEYTPTARLTPLEACAHSFF 340
+ WT+ P PE L +LL+Y P+ R+T A AH +F
Sbjct: 235 DYKGSFPKWTRKGLEEIVPNLEPEGRDLLMQLLQYDPSQRITAKTALAHPYF 286
>gi|4502743 cyclin-dependent kinase 7 [Homo sapiens]
Length = 346
Score = 172 bits (437), Expect = 4e-43
Identities = 114/306 (37%), Positives = 164/306 (53%), Gaps = 31/306 (10%)
Query: 56 YTDTKVIGNGSFGVVYQAKLCDSGELVAIKKVLQDKRFKN---------RELQIMRKLDH 106
Y +G G F VY+A+ ++ ++VAIKK+ R + RE++++++L H
Sbjct: 12 YEKLDFLGEGQFATVYKARDKNTNQIVAIKKIKLGHRSEAKDGINRTALREIKLLQELSH 71
Query: 107 CNIVRLRYFFYSSGEKKDEVYLNLVLDYVPETVYRVARHYSRAKQTLPVIYVKLYMYQLF 166
NI+ L F G K + ++LV D++ + + + S L ++K YM
Sbjct: 72 PNIIGLLDAF---GHKSN---ISLVFDFMETDLEVIIKDNSLV---LTPSHIKAYMLMTL 122
Query: 167 RSLAYIHSFGICHRDIKPQNLLLDPDTAVLKLCDFGSAKQLVRGEPNVSY---ICSRYYR 223
+ L Y+H I HRD+KP NLLLD + VLKL DFG AK G PN +Y + +R+YR
Sbjct: 123 QGLEYLHQHWILHRDLKPNNLLLD-ENGVLKLADFGLAKSF--GSPNRAYTHQVVTRWYR 179
Query: 224 APELIFGATDYTSSIDVWSAGCVLAELLLGQPIFPGDSGVDQLVEIIKVLGTPTREQIRE 283
APEL+FGA Y +D+W+ GC+LAELLL P PGDS +DQL I + LGTPT EQ +
Sbjct: 180 APELLFGARMYGVGVDMWAVGCILAELLLRVPFLPGDSDLDQLTRIFETLGTPTEEQWPD 239
Query: 284 M--NPNYTEFK-FPQIKAHPWTKVFRPRTPPEAIALCSRLLEYTPTARLTPLEACAHSFF 340
M P+Y FK FP I H +F + + L L + P AR+T +A +F
Sbjct: 240 MCSLPDYVTFKSFPGIPLH---HIF-SAAGDDLLDLIQGLFLFNPCARITATQALKMKYF 295
Query: 341 DELRDP 346
P
Sbjct: 296 SNRPGP 301
>gi|4505569 cyclin-dependent kinase-like 2 [Homo sapiens]
Length = 493
Score = 172 bits (437), Expect = 4e-43
Identities = 100/294 (34%), Positives = 159/294 (54%), Gaps = 19/294 (6%)
Query: 56 YTDTKVIGNGSFGVVYQAKLCDSGELVAIKKVLQD------KRFKNRELQIMRKLDHCNI 109
Y + ++G GS+G+V + + D+G +VAIKK L+ K+ RE++++++L H N+
Sbjct: 4 YENLGLVGEGSYGMVMKCRNKDTGRIVAIKKFLESDDDKMVKKIAMREIKLLKQLRHENL 63
Query: 110 VRLRYFFYSSGEKKDEVYLNLVLDYVPETVYRVARHYSRAKQTLPVIYVKLYMYQLFRSL 169
V L +KK YL V ++V T+ + L V+ Y++Q+ +
Sbjct: 64 VNL----LEVCKKKKRWYL--VFEFVDHTILDDLELFPNG---LDYQVVQKYLFQIINGI 114
Query: 170 AYIHSFGICHRDIKPQNLLLDPDTAVLKLCDFGSAKQLVR-GEPNVSYICSRYYRAPELI 228
+ HS I HRDIKP+N+L+ + V+KLCDFG A+ L GE Y+ +R+YRAPEL+
Sbjct: 115 GFCHSHNIIHRDIKPENILVS-QSGVVKLCDFGFARTLAAPGEVYTDYVATRWYRAPELL 173
Query: 229 FGATDYTSSIDVWSAGCVLAELLLGQPIFPGDSGVDQLVEIIKVLGT--PTREQIREMNP 286
G Y ++DVW+ GC++ E+ +G+P+FPGDS +DQL I+ LG P +++ NP
Sbjct: 174 VGDVKYGKAVDVWAIGCLVTEMFMGEPLFPGDSDIDQLYHIMMCLGNLIPRHQELFNKNP 233
Query: 287 NYTEFKFPQIKAHPWTKVFRPRTPPEAIALCSRLLEYTPTARLTPLEACAHSFF 340
+ + P+IK + P+ I L + L P R E H FF
Sbjct: 234 VFAGVRLPEIKEREPLERRYPKLSEVVIDLAKKCLHIDPDKRPFCAELLHHDFF 287
>gi|16936528 cyclin-dependent kinase 2 isoform 1 [Homo sapiens]
Length = 298
Score = 170 bits (430), Expect = 3e-42
Identities = 102/304 (33%), Positives = 176/304 (57%), Gaps = 26/304 (8%)
Query: 55 SYTDTKVIGNGSFGVVYQAKLCDSGELVAIKKVLQDKRFKN------RELQIMRKLDHCN 108
++ + IG G++GVVY+A+ +GE+VA+KK+ D + RE+ ++++L+H N
Sbjct: 3 NFQKVEKIGEGTYGVVYKARNKLTGEVVALKKIRLDTETEGVPSTAIREISLLKELNHPN 62
Query: 109 IVRLRYFFYSSGEKKDEVYLNLVLDYVPETVYRVARHYSRAKQTLPVIYVKLYMYQLFRS 168
IV+L ++ + L LV +++ + + + + A +P+ +K Y++QL +
Sbjct: 63 IVKLLDVIHTENK------LYLVFEFLHQDLKKFMD--ASALTGIPLPLIKSYLFQLLQG 114
Query: 169 LAYIHSFGICHRDIKPQNLLLDPDTAVLKLCDFGSAKQLVRGEPNVSY---ICSRYYRAP 225
LA+ HS + HRD+KPQNLL++ + A+ KL DFG A+ G P +Y + + +YRAP
Sbjct: 115 LAFCHSHRVLHRDLKPQNLLINTEGAI-KLADFGLARAF--GVPVRTYTHEVVTLWYRAP 171
Query: 226 ELIFGATDYTSSIDVWSAGCVLAELLLGQPIFPGDSGVDQLVEIIKVLGTPTR---EQIR 282
E++ G Y++++D+WS GC+ AE++ + +FPGDS +DQL I + LGTP +
Sbjct: 172 EILLGCKYYSTAVDIWSLGCIFAEMVTRRALFPGDSEIDQLFRIFRTLGTPDEVVWPGVT 231
Query: 283 EMNPNYTEFKFPQIKAHPWTKVFRPRTPPEAIALCSRLLEYTPTARLTPLEACAHSFFDE 342
M P+Y FP+ ++KV P + +L S++L Y P R++ A AH FF +
Sbjct: 232 SM-PDYKP-SFPKWARQDFSKVV-PPLDEDGRSLLSQMLHYDPNKRISAKAALAHPFFQD 288
Query: 343 LRDP 346
+ P
Sbjct: 289 VTKP 292
>gi|37596297 cyclin-dependent kinase-like 1 [Homo sapiens]
Length = 358
Score = 169 bits (428), Expect = 4e-42
Identities = 103/293 (35%), Positives = 159/293 (54%), Gaps = 19/293 (6%)
Query: 62 IGNGSFGVVYQAKLCDSGELVAIKKVLQD------KRFKNRELQIMRKLDHCNIVRLRYF 115
IG GS+GVV++ + D+G++VAIKK L+ K+ RE++++++L H N+V L
Sbjct: 11 IGEGSYGVVFKCRNRDTGQIVAIKKFLESEDDPVIKKIALREIRMLKQLKHPNLVNLLEV 70
Query: 116 FYSSGEKKDEVYLNLVLDYVPETVYRVARHYSRAKQTLPVIYVKLYMYQLFRSLAYIHSF 175
F + + L+LV +Y TV Y R +P VK +Q +++ + H
Sbjct: 71 F------RRKRRLHLVFEYCDHTVLHELDRYQRG---VPEHLVKSITWQTLQAVNFCHKH 121
Query: 176 GICHRDIKPQNLLLDPDTAVLKLCDFGSAKQLVR-GEPNVSYICSRYYRAPELIFGATDY 234
HRD+KP+N+L+ + V+KLCDFG A+ L + Y+ +R+YR+PEL+ G T Y
Sbjct: 122 NCIHRDVKPENILITKHS-VIKLCDFGFARLLTGPSDYYTDYVATRWYRSPELLVGDTQY 180
Query: 235 TSSIDVWSAGCVLAELLLGQPIFPGDSGVDQLVEIIKVLG--TPTREQIREMNPNYTEFK 292
+DVW+ GCV AELL G P++PG S VDQL I K LG P +Q+ N ++ K
Sbjct: 181 GPPVDVWAIGCVFAELLSGVPLWPGKSDVDQLYLIRKTLGDLIPRHQQVFSTNQYFSGVK 240
Query: 293 FPQIKAHPWTKVFRPRTPPEAIALCSRLLEYTPTARLTPLEACAHSFFDELRD 345
P + ++ P A+ L L PT RLT + H +F+ +R+
Sbjct: 241 IPDPEDMEPLELKFPNISYPALGLLKGCLHMDPTQRLTCEQLLHHPYFENIRE 293
>gi|20986497 mitogen-activated protein kinase 7 isoform 1 [Homo
sapiens]
Length = 816
Score = 166 bits (420), Expect = 4e-41
Identities = 100/306 (32%), Positives = 166/306 (54%), Gaps = 20/306 (6%)
Query: 56 YTDTKVIGNGSFGVVYQAKLCDSGELVAIKK------VLQDKRFKNRELQIMRKLDHCNI 109
Y + IGNG++GVV A+ +G+ VAIKK V+ + + REL+I++ H NI
Sbjct: 55 YEIIETIGNGAYGVVSSARRRLTGQQVAIKKIPNAFDVVTNAKRTLRELKILKHFKHDNI 114
Query: 110 VRLRYFFYSSGEKKDEVYLNLVLDYVPETVYRVARHYSRAKQTLPVIYVKLYMYQLFRSL 169
+ ++ + + + +VLD + ++++ + Q L + +V+ ++YQL R L
Sbjct: 115 IAIKDILRPTVPYGEFKSVYVVLDLMESDLHQIIH----SSQPLTLEHVRYFLYQLLRGL 170
Query: 170 AYIHSFGICHRDIKPQNLLLDPDTAVLKLCDFGSAKQLVRGEPN-----VSYICSRYYRA 224
Y+HS + HRD+KP NLL++ + LK+ DFG A+ L Y+ +R+YRA
Sbjct: 171 KYMHSAQVIHRDLKPSNLLVN-ENCELKIGDFGMARGLCTSPAEHQYFMTEYVATRWYRA 229
Query: 225 PELIFGATDYTSSIDVWSAGCVLAELLLGQPIFPGDSGVDQLVEIIKVLGTPTREQIREM 284
PEL+ +YT +ID+WS GC+ E+L + +FPG + V QL I+ VLGTP+ I+ +
Sbjct: 230 PELMLSLHEYTQAIDLWSVGCIFGEMLARRQLFPGKNYVHQLQLIMMVLGTPSPAVIQAV 289
Query: 285 NPNYTEF---KFPQIKAHPWTKVFRPRTPPEAIALCSRLLEYTPTARLTPLEACAHSFFD 341
P + PW V+ P +A++L R+L + P+AR++ A H F
Sbjct: 290 GAERVRAYIQSLPPRQPVPWETVY-PGADRQALSLLGRMLRFEPSARISAAAALRHPFLA 348
Query: 342 ELRDPN 347
+ DP+
Sbjct: 349 KYHDPD 354
>gi|209529736 mitogen-activated protein kinase 7 isoform 1 [Homo
sapiens]
Length = 816
Score = 166 bits (420), Expect = 4e-41
Identities = 100/306 (32%), Positives = 166/306 (54%), Gaps = 20/306 (6%)
Query: 56 YTDTKVIGNGSFGVVYQAKLCDSGELVAIKK------VLQDKRFKNRELQIMRKLDHCNI 109
Y + IGNG++GVV A+ +G+ VAIKK V+ + + REL+I++ H NI
Sbjct: 55 YEIIETIGNGAYGVVSSARRRLTGQQVAIKKIPNAFDVVTNAKRTLRELKILKHFKHDNI 114
Query: 110 VRLRYFFYSSGEKKDEVYLNLVLDYVPETVYRVARHYSRAKQTLPVIYVKLYMYQLFRSL 169
+ ++ + + + +VLD + ++++ + Q L + +V+ ++YQL R L
Sbjct: 115 IAIKDILRPTVPYGEFKSVYVVLDLMESDLHQIIH----SSQPLTLEHVRYFLYQLLRGL 170
Query: 170 AYIHSFGICHRDIKPQNLLLDPDTAVLKLCDFGSAKQLVRGEPN-----VSYICSRYYRA 224
Y+HS + HRD+KP NLL++ + LK+ DFG A+ L Y+ +R+YRA
Sbjct: 171 KYMHSAQVIHRDLKPSNLLVN-ENCELKIGDFGMARGLCTSPAEHQYFMTEYVATRWYRA 229
Query: 225 PELIFGATDYTSSIDVWSAGCVLAELLLGQPIFPGDSGVDQLVEIIKVLGTPTREQIREM 284
PEL+ +YT +ID+WS GC+ E+L + +FPG + V QL I+ VLGTP+ I+ +
Sbjct: 230 PELMLSLHEYTQAIDLWSVGCIFGEMLARRQLFPGKNYVHQLQLIMMVLGTPSPAVIQAV 289
Query: 285 NPNYTEF---KFPQIKAHPWTKVFRPRTPPEAIALCSRLLEYTPTARLTPLEACAHSFFD 341
P + PW V+ P +A++L R+L + P+AR++ A H F
Sbjct: 290 GAERVRAYIQSLPPRQPVPWETVY-PGADRQALSLLGRMLRFEPSARISAAAALRHPFLA 348
Query: 342 ELRDPN 347
+ DP+
Sbjct: 349 KYHDPD 354
>gi|209529734 mitogen-activated protein kinase 7 isoform 1 [Homo
sapiens]
Length = 816
Score = 166 bits (420), Expect = 4e-41
Identities = 100/306 (32%), Positives = 166/306 (54%), Gaps = 20/306 (6%)
Query: 56 YTDTKVIGNGSFGVVYQAKLCDSGELVAIKK------VLQDKRFKNRELQIMRKLDHCNI 109
Y + IGNG++GVV A+ +G+ VAIKK V+ + + REL+I++ H NI
Sbjct: 55 YEIIETIGNGAYGVVSSARRRLTGQQVAIKKIPNAFDVVTNAKRTLRELKILKHFKHDNI 114
Query: 110 VRLRYFFYSSGEKKDEVYLNLVLDYVPETVYRVARHYSRAKQTLPVIYVKLYMYQLFRSL 169
+ ++ + + + +VLD + ++++ + Q L + +V+ ++YQL R L
Sbjct: 115 IAIKDILRPTVPYGEFKSVYVVLDLMESDLHQIIH----SSQPLTLEHVRYFLYQLLRGL 170
Query: 170 AYIHSFGICHRDIKPQNLLLDPDTAVLKLCDFGSAKQLVRGEPN-----VSYICSRYYRA 224
Y+HS + HRD+KP NLL++ + LK+ DFG A+ L Y+ +R+YRA
Sbjct: 171 KYMHSAQVIHRDLKPSNLLVN-ENCELKIGDFGMARGLCTSPAEHQYFMTEYVATRWYRA 229
Query: 225 PELIFGATDYTSSIDVWSAGCVLAELLLGQPIFPGDSGVDQLVEIIKVLGTPTREQIREM 284
PEL+ +YT +ID+WS GC+ E+L + +FPG + V QL I+ VLGTP+ I+ +
Sbjct: 230 PELMLSLHEYTQAIDLWSVGCIFGEMLARRQLFPGKNYVHQLQLIMMVLGTPSPAVIQAV 289
Query: 285 NPNYTEF---KFPQIKAHPWTKVFRPRTPPEAIALCSRLLEYTPTARLTPLEACAHSFFD 341
P + PW V+ P +A++L R+L + P+AR++ A H F
Sbjct: 290 GAERVRAYIQSLPPRQPVPWETVY-PGADRQALSLLGRMLRFEPSARISAAAALRHPFLA 348
Query: 342 ELRDPN 347
+ DP+
Sbjct: 349 KYHDPD 354
>gi|4506085 mitogen-activated protein kinase 13 [Homo sapiens]
Length = 365
Score = 166 bits (419), Expect = 5e-41
Identities = 100/302 (33%), Positives = 162/302 (53%), Gaps = 21/302 (6%)
Query: 55 SYTDTKVIGNGSFGVVYQAKLCDSGELVAIKKV---LQDKRFKNR---ELQIMRKLDHCN 108
+Y +G+G++G V A SGE VAIKK+ Q + F R EL +++ + H N
Sbjct: 24 TYVSPTHVGSGAYGSVCSAIDKRSGEKVAIKKLSRPFQSEIFAKRAYRELLLLKHMQHEN 83
Query: 109 IVRLRYFFYSSGEKKDEVYLNLVLDYVPETVYRV-ARHYSRAKQTLPVIYVKLYMYQLFR 167
++ L F + ++ LV+ ++ + ++ +S K ++ +YQ+ +
Sbjct: 84 VIGLLDVFTPASSLRNFYDFYLVMPFMQTDLQKIMGMEFSEEK-------IQYLVYQMLK 136
Query: 168 SLAYIHSFGICHRDIKPQNLLLDPDTAVLKLCDFGSAKQLVRGEPNVSYICSRYYRAPEL 227
L YIHS G+ HRD+KP NL ++ D LK+ DFG A+ Y+ +R+YRAPE+
Sbjct: 137 GLKYIHSAGVVHRDLKPGNLAVNEDCE-LKILDFGLARHA--DAEMTGYVVTRWYRAPEV 193
Query: 228 IFGATDYTSSIDVWSAGCVLAELLLGQPIFPGDSGVDQLVEIIKVLGTPTREQIREMNPN 287
I Y ++D+WS GC++AE+L G+ +F G +DQL +I+KV G P E ++++N
Sbjct: 194 ILSWMHYNQTVDIWSVGCIMAEMLTGKTLFKGKDYLDQLTQILKVTGVPGTEFVQKLNDK 253
Query: 288 YTEF---KFPQIKAHPWTKVFRPRTPPEAIALCSRLLEYTPTARLTPLEACAHSFFDELR 344
+ PQ +T++F PR P+A L ++LE RLT +A H FF+ R
Sbjct: 254 AAKSYIQSLPQTPRKDFTQLF-PRASPQAADLLEKMLELDVDKRLTAAQALTHPFFEPFR 312
Query: 345 DP 346
DP
Sbjct: 313 DP 314
>gi|57222269 cyclin-dependent kinase-like 4 [Homo sapiens]
Length = 315
Score = 165 bits (417), Expect = 8e-41
Identities = 97/295 (32%), Positives = 158/295 (53%), Gaps = 18/295 (6%)
Query: 63 GNGSFGVVYQAKLCDSGELVAIKKVLQD------KRFKNRELQIMRKLDHCNIVRLRYFF 116
G GS+GVV++ + SG++VA+KK ++ K+ RE++++++L H N+V L F
Sbjct: 11 GEGSYGVVFKCRNKTSGQVVAVKKFVESEDDPVVKKIALREIRMLKQLKHPNLVNLIEVF 70
Query: 117 YSSGEKKDEVYLNLVLDYVPETVYRVARHYSRAKQTLPVIYVKLYMYQLFRSLAYIHSFG 176
+ ++LV +Y T+ R + +K ++Q ++L + H
Sbjct: 71 RRKRK------MHLVFEYCDHTLLN---ELERNPNGVADGVIKSVLWQTLQALNFCHIHN 121
Query: 177 ICHRDIKPQNLLLDPDTAVLKLCDFGSAKQLVRGEPNVSYICSRYYRAPELIFGATDYTS 236
HRDIKP+N+L+ ++K+CDFG A+ L+ G+ Y+ +R+YRAPEL+ G T Y S
Sbjct: 122 CIHRDIKPENILITKQ-GIIKICDFGFAQILIPGDAYTDYVATRWYRAPELLVGDTQYGS 180
Query: 237 SIDVWSAGCVLAELLLGQPIFPGDSGVDQLVEIIKVLG--TPTREQIREMNPNYTEFKFP 294
S+D+W+ GCV AELL GQP++PG S VDQL II+ LG P + I + N + P
Sbjct: 181 SVDIWAIGCVFAELLTGQPLWPGKSDVDQLYLIIRTLGKLIPRHQSIFKSNGFFHGISIP 240
Query: 295 QIKAHPWTKVFRPRTPPEAIALCSRLLEYTPTARLTPLEACAHSFFDELRDPNVK 349
+ + + P A+ L+ P RLT + S+FD ++ +K
Sbjct: 241 EPEDMETLEEKFSDVHPVALNFMKGCLKMNPDDRLTCSQLLESSYFDSFQEAQIK 295
>gi|20986531 mitogen-activated protein kinase 1 [Homo sapiens]
Length = 360
Score = 164 bits (414), Expect = 2e-40
Identities = 100/305 (32%), Positives = 166/305 (54%), Gaps = 22/305 (7%)
Query: 56 YTDTKVIGNGSFGVVYQAKLCDSGELVAIKKV--LQDKRFKNR---ELQIMRKLDHCNIV 110
YT+ IG G++G+V A + VAIKK+ + + + R E++I+ + H NI+
Sbjct: 25 YTNLSYIGEGAYGMVCSAYDNVNKVRVAIKKISPFEHQTYCQRTLREIKILLRFRHENII 84
Query: 111 RLRYFFYSSG-EKKDEVYLNLVLDYVPETVYRVARHYSRAKQTLPVIYVKLYMYQLFRSL 169
+ + E+ +VY+ V D + +Y++ + Q L ++ ++YQ+ R L
Sbjct: 85 GINDIIRAPTIEQMKDVYI--VQDLMETDLYKLLK-----TQHLSNDHICYFLYQILRGL 137
Query: 170 AYIHSFGICHRDIKPQNLLLDPDTAVLKLCDFGSAKQLVRGEPNVS----YICSRYYRAP 225
YIHS + HRD+KP NLLL+ T LK+CDFG A+ + Y+ +R+YRAP
Sbjct: 138 KYIHSANVLHRDLKPSNLLLNT-TCDLKICDFGLARVADPDHDHTGFLTEYVATRWYRAP 196
Query: 226 ELIFGATDYTSSIDVWSAGCVLAELLLGQPIFPGDSGVDQLVEIIKVLGTPTREQIR--- 282
E++ + YT SID+WS GC+LAE+L +PIFPG +DQL I+ +LG+P++E +
Sbjct: 197 EIMLNSKGYTKSIDIWSVGCILAEMLSNRPIFPGKHYLDQLNHILGILGSPSQEDLNCII 256
Query: 283 EMNPNYTEFKFPQIKAHPWTKVFRPRTPPEAIALCSRLLEYTPTARLTPLEACAHSFFDE 342
+ P PW ++F P +A+ L ++L + P R+ +A AH + ++
Sbjct: 257 NLKARNYLLSLPHKNKVPWNRLF-PNADSKALDLLDKMLTFNPHKRIEVEQALAHPYLEQ 315
Query: 343 LRDPN 347
DP+
Sbjct: 316 YYDPS 320
>gi|66932916 mitogen-activated protein kinase 1 [Homo sapiens]
Length = 360
Score = 164 bits (414), Expect = 2e-40
Identities = 100/305 (32%), Positives = 166/305 (54%), Gaps = 22/305 (7%)
Query: 56 YTDTKVIGNGSFGVVYQAKLCDSGELVAIKKV--LQDKRFKNR---ELQIMRKLDHCNIV 110
YT+ IG G++G+V A + VAIKK+ + + + R E++I+ + H NI+
Sbjct: 25 YTNLSYIGEGAYGMVCSAYDNVNKVRVAIKKISPFEHQTYCQRTLREIKILLRFRHENII 84
Query: 111 RLRYFFYSSG-EKKDEVYLNLVLDYVPETVYRVARHYSRAKQTLPVIYVKLYMYQLFRSL 169
+ + E+ +VY+ V D + +Y++ + Q L ++ ++YQ+ R L
Sbjct: 85 GINDIIRAPTIEQMKDVYI--VQDLMETDLYKLLK-----TQHLSNDHICYFLYQILRGL 137
Query: 170 AYIHSFGICHRDIKPQNLLLDPDTAVLKLCDFGSAKQLVRGEPNVS----YICSRYYRAP 225
YIHS + HRD+KP NLLL+ T LK+CDFG A+ + Y+ +R+YRAP
Sbjct: 138 KYIHSANVLHRDLKPSNLLLNT-TCDLKICDFGLARVADPDHDHTGFLTEYVATRWYRAP 196
Query: 226 ELIFGATDYTSSIDVWSAGCVLAELLLGQPIFPGDSGVDQLVEIIKVLGTPTREQIR--- 282
E++ + YT SID+WS GC+LAE+L +PIFPG +DQL I+ +LG+P++E +
Sbjct: 197 EIMLNSKGYTKSIDIWSVGCILAEMLSNRPIFPGKHYLDQLNHILGILGSPSQEDLNCII 256
Query: 283 EMNPNYTEFKFPQIKAHPWTKVFRPRTPPEAIALCSRLLEYTPTARLTPLEACAHSFFDE 342
+ P PW ++F P +A+ L ++L + P R+ +A AH + ++
Sbjct: 257 NLKARNYLLSLPHKNKVPWNRLF-PNADSKALDLLDKMLTFNPHKRIEVEQALAHPYLEQ 315
Query: 343 LRDPN 347
DP+
Sbjct: 316 YYDPS 320
>gi|83367069 cyclin-dependent kinase-like 5 [Homo sapiens]
Length = 1030
Score = 160 bits (406), Expect = 2e-39
Identities = 99/250 (39%), Positives = 144/250 (57%), Gaps = 22/250 (8%)
Query: 61 VIGNGSFGVVYQAKLCDSGELVAIKKVLQDKRFKN------RELQIMRKLDHCNIVRLRY 114
V+G G++GVV + + ++ E+VAIKK + + REL+++R L NIV L+
Sbjct: 18 VVGEGAYGVVLKCRHKETHEIVAIKKFKDSEENEEVKETTLRELKMLRTLKQENIVELKE 77
Query: 115 FFYSSGEKKDEVYLNLVLDYVPETVYRVARHYSRAKQTLPVIYVKLYMYQLFRSLAYIHS 174
F G+ L LV +YV + + + +P VK Y+YQL +++ + H
Sbjct: 78 AFRRRGK------LYLVFEYVEKNMLELLEEMPNG---VPPEKVKSYIYQLIKAIHWCHK 128
Query: 175 FGICHRDIKPQNLLLDPDTAVLKLCDFGSAKQLVRGEPN--VSYICSRYYRAPELIFGAT 232
I HRDIKP+NLL+ + VLKLCDFG A+ L G Y+ +R+YR+PEL+ GA
Sbjct: 129 NDIVHRDIKPENLLISHND-VLKLCDFGFARNLSEGNNANYTEYVATRWYRSPELLLGAP 187
Query: 233 DYTSSIDVWSAGCVLAELLLGQPIFPGDSGVDQLVEIIKVLGTPTREQIR--EMNPNYTE 290
Y S+D+WS GC+L EL GQP+FPG+S +DQL I KVLG EQ++ NP +
Sbjct: 188 -YGKSVDMWSVGCILGELSDGQPLFPGESEIDQLFTIQKVLGPLPSEQMKLFYSNPRFHG 246
Query: 291 FKFPQIKAHP 300
+FP + HP
Sbjct: 247 LRFPAVN-HP 255
>gi|4507281 cyclin-dependent kinase-like 5 [Homo sapiens]
Length = 1030
Score = 160 bits (406), Expect = 2e-39
Identities = 99/250 (39%), Positives = 144/250 (57%), Gaps = 22/250 (8%)
Query: 61 VIGNGSFGVVYQAKLCDSGELVAIKKVLQDKRFKN------RELQIMRKLDHCNIVRLRY 114
V+G G++GVV + + ++ E+VAIKK + + REL+++R L NIV L+
Sbjct: 18 VVGEGAYGVVLKCRHKETHEIVAIKKFKDSEENEEVKETTLRELKMLRTLKQENIVELKE 77
Query: 115 FFYSSGEKKDEVYLNLVLDYVPETVYRVARHYSRAKQTLPVIYVKLYMYQLFRSLAYIHS 174
F G+ L LV +YV + + + +P VK Y+YQL +++ + H
Sbjct: 78 AFRRRGK------LYLVFEYVEKNMLELLEEMPNG---VPPEKVKSYIYQLIKAIHWCHK 128
Query: 175 FGICHRDIKPQNLLLDPDTAVLKLCDFGSAKQLVRGEPN--VSYICSRYYRAPELIFGAT 232
I HRDIKP+NLL+ + VLKLCDFG A+ L G Y+ +R+YR+PEL+ GA
Sbjct: 129 NDIVHRDIKPENLLISHND-VLKLCDFGFARNLSEGNNANYTEYVATRWYRSPELLLGAP 187
Query: 233 DYTSSIDVWSAGCVLAELLLGQPIFPGDSGVDQLVEIIKVLGTPTREQIR--EMNPNYTE 290
Y S+D+WS GC+L EL GQP+FPG+S +DQL I KVLG EQ++ NP +
Sbjct: 188 -YGKSVDMWSVGCILGELSDGQPLFPGESEIDQLFTIQKVLGPLPSEQMKLFYSNPRFHG 246
Query: 291 FKFPQIKAHP 300
+FP + HP
Sbjct: 247 LRFPAVN-HP 255
>gi|89903018 cell cycle related kinase isoform 3 [Homo sapiens]
Length = 346
Score = 160 bits (405), Expect = 2e-39
Identities = 98/291 (33%), Positives = 161/291 (55%), Gaps = 24/291 (8%)
Query: 62 IGNGSFGVVYQAKLCDSGELVAIKKV----LQDKRFKNRELQIMRKL----DHCNIVRLR 113
IG G+ G+V++AK ++GE+VA+KKV L+D F N+ L+ ++ L D+ +V+L+
Sbjct: 10 IGEGAHGIVFKAKHVETGEIVALKKVALRRLEDG-FPNQALREIKALQEMEDNQYVVQLK 68
Query: 114 YFFYSSGEKKDEVYLNLVLDYVPETVYRVARHYSRAKQTLPVIYVKLYMYQLFRSLAYIH 173
F G L +++ + V RH A++ L VK Y+ L + +A+ H
Sbjct: 69 AVFPHGGG------FVLAFEFMLSDLAEVVRH---AQRPLAQAQVKSYLQMLLKGVAFCH 119
Query: 174 SFGICHRDIKPQNLLLDPDTAVLKLCDFGSAKQLVRGEPNV--SYICSRYYRAPELIFGA 231
+ I HRD+KP NLL+ + LK+ DFG A+ + + +R+YRAPEL++GA
Sbjct: 120 ANNIVHRDLKPANLLISA-SGQLKIADFGLARVFSPDGSRLYTHQVATRWYRAPELLYGA 178
Query: 232 TDYTSSIDVWSAGCVLAELLLGQPIFPGDSGVDQLVEIIKVLGTPTREQIREMN--PNYT 289
Y +D+WS GC++ ELL G P+FPG + ++QL ++++LGTP + E+ P+Y
Sbjct: 179 RQYDQGVDLWSVGCIMGELLNGSPLFPGKNDIEQLCYVLRILGTPNPQVWPELTELPDYN 238
Query: 290 EFKFPQIKAHPWTKVFRPRTPPEAIALCSRLLEYTPTARLTPLEACAHSFF 340
+ F + P +V P P+A+ L + L Y P R+ +A H +F
Sbjct: 239 KISFKEQVPMPLEEVL-PDVSPQALDLLGQFLLYPPHQRIAASKALLHQYF 288
>gi|21040235 PFTAIRE protein kinase 2 [Homo sapiens]
Length = 384
Score = 159 bits (402), Expect = 4e-39
Identities = 108/337 (32%), Positives = 174/337 (51%), Gaps = 33/337 (9%)
Query: 55 SYTDTKVIGNGSFGVVYQAKLCDSGELVAIKKVLQDKR-----FKNRELQIMRKLDHCNI 109
SY + + +G GS+ VY+ +G+LVA+K + + RE +++ L H NI
Sbjct: 51 SYLNLEKLGEGSYATVYKGISRINGQLVALKVISMNAEEGVPFTAIREASLLKGLKHANI 110
Query: 110 VRLRYFFYSSGEKKDEVYLNLVLDYVPETVYR-VARHYSRAKQTLPVIYVKLYMYQLFRS 168
V L D ++ L +V E ++ +A++ S+ L V+L+M+QL R
Sbjct: 111 VLLH----------DIIHTKETLTFVFEYMHTDLAQYMSQHPGGLHPHNVRLFMFQLLRG 160
Query: 169 LAYIHSFGICHRDIKPQNLLLDPDTAVLKLCDFGSAK-QLVRGEPNVSYICSRYYRAPEL 227
LAYIH + HRD+KPQNLL+ LKL DFG A+ + + + S + + +YR P+
Sbjct: 161 LAYIHHQHVLHRDLKPQNLLIS-HLGELKLADFGLARAKSIPSQTYSSEVVTLWYRPPDA 219
Query: 228 IFGATDYTSSIDVWSAGCVLAELLLGQPIFPGDSGV-DQLVEIIKVLGTPTRE------Q 280
+ GAT+Y+S +D+W AGC+ E+ GQP+FPG S + +QL +I +VLG PT + +
Sbjct: 220 LLGATEYSSELDIWGAGCIFIEMFQGQPLFPGVSNILEQLEKIWEVLGVPTEDTWPGVSK 279
Query: 281 IREMNPNYTEFKFPQIKAHPWTKVFRPRTPPEAIALCSRLLEYTPTARLTPLEACAHSFF 340
+ NP + P+ W ++ R PEA L S++L+ P R++ EA H +F
Sbjct: 280 LPNYNPEWFPLPTPRSLHVVWNRLGR---VPEAEDLASQMLKGFPRDRVSAQEALVHDYF 336
Query: 341 DELRDPNVKLPNGRDTPALFNFTTQELSSNPPLATIL 377
L +LP+ FT + P + +L
Sbjct: 337 SALPSQLYQLPDEESL-----FTVSGVRLKPEMCDLL 368
>gi|197333744 PCTAIRE protein kinase 1 isoform 2 [Homo sapiens]
Length = 502
Score = 158 bits (399), Expect = 1e-38
Identities = 102/339 (30%), Positives = 175/339 (51%), Gaps = 26/339 (7%)
Query: 55 SYTDTKVIGNGSFGVVYQAKLCDSGELVAIKKVLQDKR-----FKNRELQIMRKLDHCNI 109
+Y +G G++ VY+ K + LVA+K++ + RE+ +++ L H NI
Sbjct: 170 TYIKLDKLGEGTYATVYKGKSKLTDNLVALKEIRLEHEEGAPCTAIREVSLLKDLKHANI 229
Query: 110 VRLRYFFYSSGEKKDEVYLNLVLDYVPETVYRVARHYSRAKQTLPVIYVKLYMYQLFRSL 169
V L ++ E L LV +Y+ + + ++ + + VKL+++QL R L
Sbjct: 230 VTLHDIIHT------EKSLTLVFEYLDKDL---KQYLDDCGNIINMHNVKLFLFQLLRGL 280
Query: 170 AYIHSFGICHRDIKPQNLLLDPDTAVLKLCDFGSAKQLVRGEPNVSY---ICSRYYRAPE 226
AY H + HRD+KPQNLL++ + LKL DFG A+ + P +Y + + +YR P+
Sbjct: 281 AYCHRQKVLHRDLKPQNLLIN-ERGELKLADFGLAR--AKSIPTKTYSNEVVTLWYRPPD 337
Query: 227 LIFGATDYTSSIDVWSAGCVLAELLLGQPIFPGDSGVDQLVEIIKVLGTPTREQIREM-- 284
++ G+TDY++ ID+W GC+ E+ G+P+FPG + +QL I ++LGTPT E +
Sbjct: 338 ILLGSTDYSTQIDMWGVGCIFYEMATGRPLFPGSTVEEQLHFIFRILGTPTEETWPGILS 397
Query: 285 NPNYTEFKFPQIKAHPWTKVFRPRTPPEAIALCSRLLEYTPTARLTPLEACAHSFFDELR 344
N + + +P+ +A PR + L ++LL++ R++ +A H FF L
Sbjct: 398 NEEFKTYNYPKYRAEALLS-HAPRLDSDGADLLTKLLQFEGRNRISAEDAMKHPFFLSLG 456
Query: 345 DPNVKLPNGRDTPALFNFTTQELSSNPPLATILIPPHAR 383
+ KLP DT ++F +L L + +P R
Sbjct: 457 ERIHKLP---DTTSIFALKEIQLQKEASLRSSSMPDSGR 492
>gi|5453860 PCTAIRE protein kinase 1 isoform 1 [Homo sapiens]
Length = 496
Score = 158 bits (399), Expect = 1e-38
Identities = 102/339 (30%), Positives = 175/339 (51%), Gaps = 26/339 (7%)
Query: 55 SYTDTKVIGNGSFGVVYQAKLCDSGELVAIKKVLQDKR-----FKNRELQIMRKLDHCNI 109
+Y +G G++ VY+ K + LVA+K++ + RE+ +++ L H NI
Sbjct: 164 TYIKLDKLGEGTYATVYKGKSKLTDNLVALKEIRLEHEEGAPCTAIREVSLLKDLKHANI 223
Query: 110 VRLRYFFYSSGEKKDEVYLNLVLDYVPETVYRVARHYSRAKQTLPVIYVKLYMYQLFRSL 169
V L ++ E L LV +Y+ + + ++ + + VKL+++QL R L
Sbjct: 224 VTLHDIIHT------EKSLTLVFEYLDKDL---KQYLDDCGNIINMHNVKLFLFQLLRGL 274
Query: 170 AYIHSFGICHRDIKPQNLLLDPDTAVLKLCDFGSAKQLVRGEPNVSY---ICSRYYRAPE 226
AY H + HRD+KPQNLL++ + LKL DFG A+ + P +Y + + +YR P+
Sbjct: 275 AYCHRQKVLHRDLKPQNLLIN-ERGELKLADFGLAR--AKSIPTKTYSNEVVTLWYRPPD 331
Query: 227 LIFGATDYTSSIDVWSAGCVLAELLLGQPIFPGDSGVDQLVEIIKVLGTPTREQIREM-- 284
++ G+TDY++ ID+W GC+ E+ G+P+FPG + +QL I ++LGTPT E +
Sbjct: 332 ILLGSTDYSTQIDMWGVGCIFYEMATGRPLFPGSTVEEQLHFIFRILGTPTEETWPGILS 391
Query: 285 NPNYTEFKFPQIKAHPWTKVFRPRTPPEAIALCSRLLEYTPTARLTPLEACAHSFFDELR 344
N + + +P+ +A PR + L ++LL++ R++ +A H FF L
Sbjct: 392 NEEFKTYNYPKYRAEALLS-HAPRLDSDGADLLTKLLQFEGRNRISAEDAMKHPFFLSLG 450
Query: 345 DPNVKLPNGRDTPALFNFTTQELSSNPPLATILIPPHAR 383
+ KLP DT ++F +L L + +P R
Sbjct: 451 ERIHKLP---DTTSIFALKEIQLQKEASLRSSSMPDSGR 486
>gi|4826675 cyclin-dependent kinase 5 [Homo sapiens]
Length = 292
Score = 157 bits (398), Expect = 1e-38
Identities = 106/303 (34%), Positives = 165/303 (54%), Gaps = 26/303 (8%)
Query: 56 YTDTKVIGNGSFGVVYQAKLCDSGELVAIKKVLQDKRFKN------RELQIMRKLDHCNI 109
Y + IG G++G V++AK ++ E+VA+K+V D + RE+ ++++L H NI
Sbjct: 4 YEKLEKIGEGTYGTVFKAKNRETHEIVALKRVRLDDDDEGVPSSALREICLLKELKHKNI 63
Query: 110 VRLRYFFYSSGEKKDEVYLNLVLDYVPETVYRVARHYSRAKQTLPVIYVKLYMYQLFRSL 169
VRL +S +KK L LV ++ + + +++ L VK +++QL + L
Sbjct: 64 VRLHDVLHS--DKK----LTLVFEFCDQDL---KKYFDSCNGDLDPEIVKSFLFQLLKGL 114
Query: 170 AYIHSFGICHRDIKPQNLLLDPDTAVLKLCDFGSAKQLVRGEPNVSY---ICSRYYRAPE 226
+ HS + HRD+KPQNLL++ + LKL DFG A+ G P Y + + +YR P+
Sbjct: 115 GFCHSRNVLHRDLKPQNLLINRN-GELKLADFGLARAF--GIPVRCYSAEVVTLWYRPPD 171
Query: 227 LIFGATDYTSSIDVWSAGCVLAELL-LGQPIFPGDSGVDQLVEIIKVLGTPTREQIREMN 285
++FGA Y++SID+WSAGC+ AEL G+P+FPG+ DQL I ++LGTPT EQ M
Sbjct: 172 VLFGAKLYSTSIDMWSAGCIFAELANAGRPLFPGNDVDDQLKRIFRLLGTPTEEQWPSMT 231
Query: 286 --PNYTEFKFPQIKAHPWTKVFRPRTPPEAIALCSRLLEYTPTARLTPLEACAHSFFDEL 343
P+Y +P A P+ L LL+ P R++ EA H +F +
Sbjct: 232 KLPDYK--PYPMYPATTSLVNVVPKLNATGRDLLQNLLKCNPVQRISAEEALQHPYFSDF 289
Query: 344 RDP 346
P
Sbjct: 290 CPP 292
>gi|20128774 mitogen-activated protein kinase 11 [Homo sapiens]
Length = 364
Score = 157 bits (398), Expect = 1e-38
Identities = 97/294 (32%), Positives = 158/294 (53%), Gaps = 18/294 (6%)
Query: 62 IGNGSFGVVYQAKLCDSGELVAIKKV------LQDKRFKNRELQIMRKLDHCNIVRLRYF 115
+G+G++G V A + VA+KK+ L R REL++++ L H N++ L
Sbjct: 30 VGSGAYGSVCSAYDARLRQKVAVKKLSRPFQSLIHARRTYRELRLLKHLKHENVIGLLDV 89
Query: 116 FYSSGEKKDEVYLNLVLDYVPETVYRVARHYSRAKQTLPVIYVKLYMYQLFRSLAYIHSF 175
F + +D + LV + + + + Q L +V+ +YQL R L YIHS
Sbjct: 90 FTPATSIEDFSEVYLVTTLMGADLNNIVKC-----QALSDEHVQFLVYQLLRGLKYIHSA 144
Query: 176 GICHRDIKPQNLLLDPDTAVLKLCDFGSAKQLVRGEPNVSYICSRYYRAPELIFGATDYT 235
GI HRD+KP N+ ++ D L++ DFG A+Q E Y+ +R+YRAPE++ Y
Sbjct: 145 GIIHRDLKPSNVAVNEDCE-LRILDFGLARQA--DEEMTGYVATRWYRAPEIMLNWMHYN 201
Query: 236 SSIDVWSAGCVLAELLLGQPIFPGDSGVDQLVEIIKVLGTPTREQIREMNPNYTEF---K 292
++D+WS GC++AELL G+ +FPG +DQL I++V+GTP+ E + +++ +
Sbjct: 202 QTVDIWSVGCIMAELLQGKALFPGSDYIDQLKRIMEVVGTPSPEVLAKISSEHARTYIQS 261
Query: 293 FPQIKAHPWTKVFRPRTPPEAIALCSRLLEYTPTARLTPLEACAHSFFDELRDP 346
P + + +FR P AI L R+L R++ EA AH++F + DP
Sbjct: 262 LPPMPQKDLSSIFRGAN-PLAIDLLGRMLVLDSDQRVSAAEALAHAYFSQYHDP 314
>gi|48255970 mitogen-activated protein kinase 12 [Homo sapiens]
Length = 367
Score = 157 bits (397), Expect = 2e-38
Identities = 96/300 (32%), Positives = 160/300 (53%), Gaps = 20/300 (6%)
Query: 56 YTDTKVIGNGSFGVVYQAKLCDSGELVAIKKV---LQDKRFKNR---ELQIMRKLDHCNI 109
Y D + +G+G++G V A +G VAIKK+ Q + F R EL++++ + H N+
Sbjct: 27 YRDLQPVGSGAYGAVCSAVDGRTGAKVAIKKLYRPFQSELFAKRAYRELRLLKHMRHENV 86
Query: 110 VRLRYFFYSSGEKKDEVYLNLVLDYVPETVYRVARHYSRAKQTLPVIYVKLYMYQLFRSL 169
+ L F D LV+ ++ + ++ +H + ++ +YQ+ + L
Sbjct: 87 IGLLDVFTPDETLDDFTDFYLVMPFMGTDLGKLMKHEKLGEDR-----IQFLVYQMLKGL 141
Query: 170 AYIHSFGICHRDIKPQNLLLDPDTAVLKLCDFGSAKQLVRGEPNVSYICSRYYRAPELIF 229
YIH+ GI HRD+KP NL ++ D LK+ DFG A+Q Y+ +R+YRAPE+I
Sbjct: 142 RYIHAAGIIHRDLKPGNLAVNEDCE-LKILDFGLARQA--DSEMTGYVVTRWYRAPEVIL 198
Query: 230 GATDYTSSIDVWSAGCVLAELLLGQPIFPGDSGVDQLVEIIKVLGTPTREQIREMN---- 285
YT ++D+WS GC++AE++ G+ +F G +DQL EI+KV GTP E ++ +
Sbjct: 199 NWMRYTQTVDIWSVGCIMAEMITGKTLFKGSDHLDQLKEIMKVTGTPPAEFVQRLQSDEA 258
Query: 286 PNYTEFKFPQIKAHPWTKVFRPRTPPEAIALCSRLLEYTPTARLTPLEACAHSFFDELRD 345
NY + P+++ + + P A+ L ++L R+T EA AH +F+ L D
Sbjct: 259 KNYMK-GLPELEKKDFASIL-TNASPLAVNLLEKMLVLDAEQRVTAGEALAHPYFESLHD 316
>gi|95147356 mitogen-activated protein kinase 15 [Homo sapiens]
Length = 544
Score = 155 bits (393), Expect = 5e-38
Identities = 98/308 (31%), Positives = 162/308 (52%), Gaps = 25/308 (8%)
Query: 56 YTDTKVIGNGSFGVVYQAKLCDSGELVAIKKVLQDKRFKN------RELQIMRKL-DHCN 108
Y + +G G++G+V++A +GE+VAIKK+ R K RE+ ++++ DH N
Sbjct: 13 YLLRRQLGQGAYGIVWKAVDRRTGEVVAIKKIFDAFRDKTDAQRTFREITLLQEFGDHPN 72
Query: 109 IVRLRYFFYSSGEKKDEVYLNLVLDYVPETVYRVARHYSRAKQTLPVIYVKLYMYQLFRS 168
I+ L + ++ ++YL V +++ + V R L ++V+ YQL R+
Sbjct: 73 IISLLDVIRAENDR--DIYL--VFEFMDTDLNAVIRKGG----LLQDVHVRSIFYQLLRA 124
Query: 169 LAYIHSFGICHRDIKPQNLLLDPDTAVLKLCDFGSAKQL------VRGEPNVSYICSRYY 222
++HS + HRD KP N+LLD + V KLCDFG A+ L + Y+ +R+Y
Sbjct: 125 TRFLHSGHVVHRDQKPSNVLLDANCTV-KLCDFGLARSLGDLPEGPEDQAVTEYVATRWY 183
Query: 223 RAPELIFGATDYTSSIDVWSAGCVLAELLLGQPIFPGDSGVDQLVEIIKVLGTPTREQIR 282
RAPE++ + YT +D+WS GC+L E+L G+P+FPG S + QL I++ + P+ E +
Sbjct: 184 RAPEVLLSSHRYTLGVDMWSLGCILGEMLRGRPLFPGTSTLHQLELILETIPPPSEEDLL 243
Query: 283 EMNPNYTEFKFPQIKAHP---WTKVFRPRTPPEAIALCSRLLEYTPTARLTPLEACAHSF 339
+ Q+ + P + P T PEA+ L RLL + P RL+ +A H +
Sbjct: 244 ALGSGCRASVLHQLGSRPRQTLDALLPPDTSPEALDLLRRLLVFAPDKRLSATQALQHPY 303
Query: 340 FDELRDPN 347
P+
Sbjct: 304 VQRFHCPS 311
Database: hs.faa
Posted date: Aug 4, 2009 4:42 PM
Number of letters in database: 18,247,518
Number of sequences in database: 37,866
Lambda K H
0.319 0.134 0.399
Gapped
Lambda K H
0.267 0.0410 0.140
Matrix: BLOSUM62
Gap Penalties: Existence: 11, Extension: 1
Number of Hits to DB: 17,076,880
Number of Sequences: 37866
Number of extensions: 808578
Number of successful extensions: 4287
Number of sequences better than 10.0: 30
Number of HSP's better than 10.0 without gapping: 521
Number of HSP's successfully gapped in prelim test: 240
Number of HSP's that attempted gapping in prelim test: 2203
Number of HSP's gapped (non-prelim): 952
length of query: 420
length of database: 18,247,518
effective HSP length: 105
effective length of query: 315
effective length of database: 14,271,588
effective search space: 4495550220
effective search space used: 4495550220
T: 11
A: 40
X1: 16 ( 7.4 bits)
X2: 38 (14.6 bits)
X3: 64 (24.7 bits)
S1: 41 (21.7 bits)
S2: 63 (28.9 bits)
Search results were obtained with NCBI BLAST and RefSeq entries.
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Guide to the Human Genome
Copyright © 2010 by Stewart Scherer. All rights reserved.