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Search of human proteins with 225690529
BLASTP 2.2.11 [Jun-05-2005]
Reference: Altschul, Stephen F., Thomas L. Madden, Alejandro A. Schaffer,
Jinghui Zhang, Zheng Zhang, Webb Miller, and David J. Lipman (1997),
"Gapped BLAST and PSI-BLAST: a new generation of protein database search
programs", Nucleic Acids Res. 25:3389-3402.
Query= gi|225690529 golgin, RAB6-interacting isoform a [Homo sapiens]
(394 letters)
Database: hs.faa
37,866 sequences; 18,247,518 total letters
Searching..................................................done
Score E
Sequences producing significant alignments: (bits) Value
gi|225690529 golgin, RAB6-interacting isoform a [Homo sapiens] 781 0.0
gi|225690532 golgin, RAB6-interacting isoform b [Homo sapiens] 493 e-140
gi|13259510 dynactin 1 isoform 1 [Homo sapiens] 57 2e-08
gi|205277396 dynactin 1 isoform 4 [Homo sapiens] 56 5e-08
gi|205277392 dynactin 1 isoform 3 [Homo sapiens] 56 5e-08
gi|13259508 dynactin 1 isoform 2 [Homo sapiens] 56 5e-08
gi|41872583 Rho-associated, coiled-coil containing protein kinas... 54 3e-07
gi|68161546 misshapen/NIK-related kinase isoform 4 [Homo sapiens] 53 4e-07
gi|24850117 misshapen/NIK-related kinase isoform 2 [Homo sapiens] 53 4e-07
gi|27436917 misshapen/NIK-related kinase isoform 3 [Homo sapiens] 53 4e-07
gi|7657335 misshapen/NIK-related kinase isoform 1 [Homo sapiens] 53 4e-07
gi|156766047 GRB10 interacting GYF protein 2 isoform c [Homo sap... 52 7e-07
gi|156766045 GRB10 interacting GYF protein 2 isoform a [Homo sap... 52 7e-07
gi|156766043 GRB10 interacting GYF protein 2 isoform b [Homo sap... 52 7e-07
gi|42476299 GRB10 interacting GYF protein 2 isoform b [Homo sapi... 52 7e-07
gi|115648142 centrosomal protein 164kDa [Homo sapiens] 52 1e-06
gi|41327691 kinesin-like motor protein C20orf23 [Homo sapiens] 50 5e-06
gi|95147555 microtubule-associated protein 1A [Homo sapiens] 49 6e-06
gi|148746195 trichohyalin [Homo sapiens] 49 1e-05
gi|22035604 mitogen-activated protein kinase kinase kinase kinas... 48 1e-05
gi|196115290 glial fibrillary acidic protein isoform 2 [Homo sap... 47 2e-05
gi|4503979 glial fibrillary acidic protein isoform 1 [Homo sapiens] 47 2e-05
gi|217272804 hyaluronan-mediated motility receptor isoform d [Ho... 47 2e-05
gi|217272802 hyaluronan-mediated motility receptor isoform a [Ho... 47 2e-05
gi|217416398 hyaluronan-mediated motility receptor isoform c [Ho... 47 2e-05
gi|217416394 hyaluronan-mediated motility receptor isoform b [Ho... 47 2e-05
gi|31982906 cingulin-like 1 [Homo sapiens] 47 3e-05
gi|32698688 citron [Homo sapiens] 47 4e-05
gi|41322923 plectin 1 isoform 11 [Homo sapiens] 47 4e-05
gi|41322914 plectin 1 isoform 10 [Homo sapiens] 47 4e-05
>gi|225690529 golgin, RAB6-interacting isoform a [Homo sapiens]
Length = 394
Score = 781 bits (2016), Expect = 0.0
Identities = 394/394 (100%), Positives = 394/394 (100%)
Query: 1 MSWAAVLAVAAARFGHFWGCRWPGPMAQGWAGFSEEELRRLKQTKDPFEPQRRLPAKKSR 60
MSWAAVLAVAAARFGHFWGCRWPGPMAQGWAGFSEEELRRLKQTKDPFEPQRRLPAKKSR
Sbjct: 1 MSWAAVLAVAAARFGHFWGCRWPGPMAQGWAGFSEEELRRLKQTKDPFEPQRRLPAKKSR 60
Query: 61 QQLQREKALVEQSQKLGLQDGSTSLLPEQLLSAPKQRVNVQKPPFSSPTLPSHFTLTSPV 120
QQLQREKALVEQSQKLGLQDGSTSLLPEQLLSAPKQRVNVQKPPFSSPTLPSHFTLTSPV
Sbjct: 61 QQLQREKALVEQSQKLGLQDGSTSLLPEQLLSAPKQRVNVQKPPFSSPTLPSHFTLTSPV 120
Query: 121 GDGQPQGIESQPKELGLENSHDGHNNVEILPPKPDCKLEKKKVELQEKSRWEVLQQEQRL 180
GDGQPQGIESQPKELGLENSHDGHNNVEILPPKPDCKLEKKKVELQEKSRWEVLQQEQRL
Sbjct: 121 GDGQPQGIESQPKELGLENSHDGHNNVEILPPKPDCKLEKKKVELQEKSRWEVLQQEQRL 180
Query: 181 MEEKNKRKKALLAKAIAERSKRTQAETMKLKRIQKELQALDDMVSADIGILRNRIDQASL 240
MEEKNKRKKALLAKAIAERSKRTQAETMKLKRIQKELQALDDMVSADIGILRNRIDQASL
Sbjct: 181 MEEKNKRKKALLAKAIAERSKRTQAETMKLKRIQKELQALDDMVSADIGILRNRIDQASL 240
Query: 241 DYSYARKRFDRAEAEYIAAKLDIQRKTEIKEQLTEHLCTIIQQNELRKAKKLEELMQQLD 300
DYSYARKRFDRAEAEYIAAKLDIQRKTEIKEQLTEHLCTIIQQNELRKAKKLEELMQQLD
Sbjct: 241 DYSYARKRFDRAEAEYIAAKLDIQRKTEIKEQLTEHLCTIIQQNELRKAKKLEELMQQLD 300
Query: 301 VEADEETLELEVEVERLLHEQEVESRRPVVRLERPFQPAEESVTLEFAKENRKCQEQAVS 360
VEADEETLELEVEVERLLHEQEVESRRPVVRLERPFQPAEESVTLEFAKENRKCQEQAVS
Sbjct: 301 VEADEETLELEVEVERLLHEQEVESRRPVVRLERPFQPAEESVTLEFAKENRKCQEQAVS 360
Query: 361 PKVDDQCGNSSSIPFLSPNCPNQEGNDISAALAT 394
PKVDDQCGNSSSIPFLSPNCPNQEGNDISAALAT
Sbjct: 361 PKVDDQCGNSSSIPFLSPNCPNQEGNDISAALAT 394
>gi|225690532 golgin, RAB6-interacting isoform b [Homo sapiens]
Length = 246
Score = 493 bits (1270), Expect = e-140
Identities = 246/246 (100%), Positives = 246/246 (100%)
Query: 1 MSWAAVLAVAAARFGHFWGCRWPGPMAQGWAGFSEEELRRLKQTKDPFEPQRRLPAKKSR 60
MSWAAVLAVAAARFGHFWGCRWPGPMAQGWAGFSEEELRRLKQTKDPFEPQRRLPAKKSR
Sbjct: 1 MSWAAVLAVAAARFGHFWGCRWPGPMAQGWAGFSEEELRRLKQTKDPFEPQRRLPAKKSR 60
Query: 61 QQLQREKALVEQSQKLGLQDGSTSLLPEQLLSAPKQRVNVQKPPFSSPTLPSHFTLTSPV 120
QQLQREKALVEQSQKLGLQDGSTSLLPEQLLSAPKQRVNVQKPPFSSPTLPSHFTLTSPV
Sbjct: 61 QQLQREKALVEQSQKLGLQDGSTSLLPEQLLSAPKQRVNVQKPPFSSPTLPSHFTLTSPV 120
Query: 121 GDGQPQGIESQPKELGLENSHDGHNNVEILPPKPDCKLEKKKVELQEKSRWEVLQQEQRL 180
GDGQPQGIESQPKELGLENSHDGHNNVEILPPKPDCKLEKKKVELQEKSRWEVLQQEQRL
Sbjct: 121 GDGQPQGIESQPKELGLENSHDGHNNVEILPPKPDCKLEKKKVELQEKSRWEVLQQEQRL 180
Query: 181 MEEKNKRKKALLAKAIAERSKRTQAETMKLKRIQKELQALDDMVSADIGILRNRIDQASL 240
MEEKNKRKKALLAKAIAERSKRTQAETMKLKRIQKELQALDDMVSADIGILRNRIDQASL
Sbjct: 181 MEEKNKRKKALLAKAIAERSKRTQAETMKLKRIQKELQALDDMVSADIGILRNRIDQASL 240
Query: 241 DYSYAR 246
DYSYAR
Sbjct: 241 DYSYAR 246
>gi|13259510 dynactin 1 isoform 1 [Homo sapiens]
Length = 1278
Score = 57.4 bits (137), Expect = 2e-08
Identities = 70/318 (22%), Positives = 133/318 (41%), Gaps = 29/318 (9%)
Query: 37 ELRRLKQTKDPFEPQRRLPAKKSRQQLQREKALVEQSQKLGLQDGSTSL--LPEQLLSAP 94
+LR LK K P R+ ++ + + S LG GS S L S P
Sbjct: 130 KLRGLKPKKAP--TARKTTTRRPKPTRPASTGVAGASSSLG-PSGSASAGELSSSEPSTP 186
Query: 95 KQRVNVQKPPFSSPTLPSHFTLTSPVGDGQPQGIESQPKELGLENSHDGHNNVEILPPKP 154
Q P ++P +P+ LTSP G P S+ +E D +E L K
Sbjct: 187 AQT------PLAAPIIPTP-VLTSP-GAVPPLPSPSKEEEGLRAQVRDLEEKLETLRLKR 238
Query: 155 D------CKLEKKKVELQEKSRWEVLQQEQ------RLMEEKNKRKKALLAKAIAERSKR 202
+LEK K++L++ W+ QEQ RL E + + K+AL AK
Sbjct: 239 AEDKAKLKELEKHKIQLEQVQEWKSKMQEQQADLQRRLKEARKEAKEALEAKERYMEEMA 298
Query: 203 TQAETMKLKRIQKEL-QALDDMVSADIGILRNRIDQASLDYSYARKRFDRAEAEYIAAKL 261
A+ +++ + KE+ + + + ++ L+ R+D+ + D + + ++ A+
Sbjct: 299 DTADAIEMATLDKEMAEERAESLQQEVEALKERVDELTTDLEILKAEIEEKGSDGAASSY 358
Query: 262 DIQRKTEIKEQLTEHLCTIIQQNELRKAKKLEELMQQLDVEADEETLELEVEVERLLHEQ 321
+++ E +L + +++ +L ++K E + Q +E + LE+ + L E+
Sbjct: 359 QLKQLEEQNARLKD---ALVRMRDLSSSEKQEHVKLQKLMEKKNQELEVVRQQRERLQEE 415
Query: 322 EVESRRPVVRLERPFQPA 339
++ + L+ A
Sbjct: 416 LSQAESTIDELKEQVDAA 433
Score = 42.4 bits (98), Expect = 7e-04
Identities = 51/206 (24%), Positives = 86/206 (41%), Gaps = 17/206 (8%)
Query: 133 KELGLENSHDGHNNVEILPPKPD---CKLEKKKVELQEK-SRWEVLQQEQRLMEEKNKRK 188
KE+ E + VE L + D LE K E++EK S + + +EE+N R
Sbjct: 311 KEMAEERAESLQQEVEALKERVDELTTDLEILKAEIEEKGSDGAASSYQLKQLEEQNARL 370
Query: 189 KALLAKAIAERSKRTQAETMKLKRIQKELQALDDMVSADIGILRNRIDQASLDYSYARKR 248
K L + S Q K ++K+ Q L+ ++R + ++ + S A
Sbjct: 371 KDALVRMRDLSSSEKQEHVKLQKLMEKKNQELE--------VVRQQRERLQEELSQAEST 422
Query: 249 FDRAEAEYIAAKLDIQRKTEIKEQLTEHLCTIIQQ-NELRKAKKLEELMQQLDVEADEET 307
D + E + A L + E+ E LT+ + ++ ELR+ E M +++ E E
Sbjct: 423 IDELK-EQVDAALGAE---EMVEMLTDRNLNLEEKVRELRETVGDLEAMNEMNDELQENA 478
Query: 308 LELEVEVERLLHEQEVESRRPVVRLE 333
E E+E+ L R R+E
Sbjct: 479 RETELELREQLDMAGARVREAQKRVE 504
>gi|205277396 dynactin 1 isoform 4 [Homo sapiens]
Length = 1139
Score = 56.2 bits (134), Expect = 5e-08
Identities = 60/280 (21%), Positives = 122/280 (43%), Gaps = 22/280 (7%)
Query: 77 GLQDGSTSLLPEQLLSAPK----QRVNVQKPPFSSPTLPSHFTLTSPVGDGQPQGIESQP 132
G+ S+SL P SA + + + P ++P +P+ LTSP G P S+
Sbjct: 25 GVAGASSSLGPSGSASAGELSSSEPSTPAQTPLAAPIIPTP-VLTSP-GAVPPLPSPSKE 82
Query: 133 KELGLENSHDGHNNVEILPPKPD------CKLEKKKVELQEKSRWEVLQQEQ------RL 180
+E D +E L K +LEK K++L++ W+ QEQ RL
Sbjct: 83 EEGLRAQVRDLEEKLETLRLKRAEDKAKLKELEKHKIQLEQVQEWKSKMQEQQADLQRRL 142
Query: 181 MEEKNKRKKALLAKAIAERSKRTQAETMKLKRIQKEL-QALDDMVSADIGILRNRIDQAS 239
E + + K+AL AK A+ +++ + KE+ + + + ++ L+ R+D+ +
Sbjct: 143 KEARKEAKEALEAKERYMEEMADTADAIEMATLDKEMAEERAESLQQEVEALKERVDELT 202
Query: 240 LDYSYARKRFDRAEAEYIAAKLDIQRKTEIKEQLTEHLCTIIQQNELRKAKKLEELMQQL 299
D + + ++ A+ +++ E +L + +++ +L ++K E + Q
Sbjct: 203 TDLEILKAEIEEKGSDGAASSYQLKQLEEQNARLKD---ALVRMRDLSSSEKQEHVKLQK 259
Query: 300 DVEADEETLELEVEVERLLHEQEVESRRPVVRLERPFQPA 339
+E + LE+ + L E+ ++ + L+ A
Sbjct: 260 LMEKKNQELEVVRQQRERLQEELSQAESTIDELKEQVDAA 299
Score = 42.4 bits (98), Expect = 7e-04
Identities = 51/206 (24%), Positives = 86/206 (41%), Gaps = 17/206 (8%)
Query: 133 KELGLENSHDGHNNVEILPPKPD---CKLEKKKVELQEK-SRWEVLQQEQRLMEEKNKRK 188
KE+ E + VE L + D LE K E++EK S + + +EE+N R
Sbjct: 177 KEMAEERAESLQQEVEALKERVDELTTDLEILKAEIEEKGSDGAASSYQLKQLEEQNARL 236
Query: 189 KALLAKAIAERSKRTQAETMKLKRIQKELQALDDMVSADIGILRNRIDQASLDYSYARKR 248
K L + S Q K ++K+ Q L+ ++R + ++ + S A
Sbjct: 237 KDALVRMRDLSSSEKQEHVKLQKLMEKKNQELE--------VVRQQRERLQEELSQAEST 288
Query: 249 FDRAEAEYIAAKLDIQRKTEIKEQLTEHLCTIIQQ-NELRKAKKLEELMQQLDVEADEET 307
D + E + A L + E+ E LT+ + ++ ELR+ E M +++ E E
Sbjct: 289 IDELK-EQVDAALGAE---EMVEMLTDRNLNLEEKVRELRETVGDLEAMNEMNDELQENA 344
Query: 308 LELEVEVERLLHEQEVESRRPVVRLE 333
E E+E+ L R R+E
Sbjct: 345 RETELELREQLDMAGARVREAQKRVE 370
>gi|205277392 dynactin 1 isoform 3 [Homo sapiens]
Length = 1253
Score = 56.2 bits (134), Expect = 5e-08
Identities = 60/280 (21%), Positives = 122/280 (43%), Gaps = 22/280 (7%)
Query: 77 GLQDGSTSLLPEQLLSAPK----QRVNVQKPPFSSPTLPSHFTLTSPVGDGQPQGIESQP 132
G+ S+SL P SA + + + P ++P +P+ LTSP G P S+
Sbjct: 139 GVAGASSSLGPSGSASAGELSSSEPSTPAQTPLAAPIIPTP-VLTSP-GAVPPLPSPSKE 196
Query: 133 KELGLENSHDGHNNVEILPPKPD------CKLEKKKVELQEKSRWEVLQQEQ------RL 180
+E D +E L K +LEK K++L++ W+ QEQ RL
Sbjct: 197 EEGLRAQVRDLEEKLETLRLKRAEDKAKLKELEKHKIQLEQVQEWKSKMQEQQADLQRRL 256
Query: 181 MEEKNKRKKALLAKAIAERSKRTQAETMKLKRIQKEL-QALDDMVSADIGILRNRIDQAS 239
E + + K+AL AK A+ +++ + KE+ + + + ++ L+ R+D+ +
Sbjct: 257 KEARKEAKEALEAKERYMEEMADTADAIEMATLDKEMAEERAESLQQEVEALKERVDELT 316
Query: 240 LDYSYARKRFDRAEAEYIAAKLDIQRKTEIKEQLTEHLCTIIQQNELRKAKKLEELMQQL 299
D + + ++ A+ +++ E +L + +++ +L ++K E + Q
Sbjct: 317 TDLEILKAEIEEKGSDGAASSYQLKQLEEQNARLKD---ALVRMRDLSSSEKQEHVKLQK 373
Query: 300 DVEADEETLELEVEVERLLHEQEVESRRPVVRLERPFQPA 339
+E + LE+ + L E+ ++ + L+ A
Sbjct: 374 LMEKKNQELEVVRQQRERLQEELSQAESTIDELKEQVDAA 413
Score = 42.4 bits (98), Expect = 7e-04
Identities = 51/206 (24%), Positives = 86/206 (41%), Gaps = 17/206 (8%)
Query: 133 KELGLENSHDGHNNVEILPPKPD---CKLEKKKVELQEK-SRWEVLQQEQRLMEEKNKRK 188
KE+ E + VE L + D LE K E++EK S + + +EE+N R
Sbjct: 291 KEMAEERAESLQQEVEALKERVDELTTDLEILKAEIEEKGSDGAASSYQLKQLEEQNARL 350
Query: 189 KALLAKAIAERSKRTQAETMKLKRIQKELQALDDMVSADIGILRNRIDQASLDYSYARKR 248
K L + S Q K ++K+ Q L+ ++R + ++ + S A
Sbjct: 351 KDALVRMRDLSSSEKQEHVKLQKLMEKKNQELE--------VVRQQRERLQEELSQAEST 402
Query: 249 FDRAEAEYIAAKLDIQRKTEIKEQLTEHLCTIIQQ-NELRKAKKLEELMQQLDVEADEET 307
D + E + A L + E+ E LT+ + ++ ELR+ E M +++ E E
Sbjct: 403 IDELK-EQVDAALGAE---EMVEMLTDRNLNLEEKVRELRETVGDLEAMNEMNDELQENA 458
Query: 308 LELEVEVERLLHEQEVESRRPVVRLE 333
E E+E+ L R R+E
Sbjct: 459 RETELELREQLDMAGARVREAQKRVE 484
>gi|13259508 dynactin 1 isoform 2 [Homo sapiens]
Length = 1144
Score = 56.2 bits (134), Expect = 5e-08
Identities = 60/280 (21%), Positives = 122/280 (43%), Gaps = 22/280 (7%)
Query: 77 GLQDGSTSLLPEQLLSAPK----QRVNVQKPPFSSPTLPSHFTLTSPVGDGQPQGIESQP 132
G+ S+SL P SA + + + P ++P +P+ LTSP G P S+
Sbjct: 25 GVAGASSSLGPSGSASAGELSSSEPSTPAQTPLAAPIIPTP-VLTSP-GAVPPLPSPSKE 82
Query: 133 KELGLENSHDGHNNVEILPPKPD------CKLEKKKVELQEKSRWEVLQQEQ------RL 180
+E D +E L K +LEK K++L++ W+ QEQ RL
Sbjct: 83 EEGLRAQVRDLEEKLETLRLKRAEDKAKLKELEKHKIQLEQVQEWKSKMQEQQADLQRRL 142
Query: 181 MEEKNKRKKALLAKAIAERSKRTQAETMKLKRIQKEL-QALDDMVSADIGILRNRIDQAS 239
E + + K+AL AK A+ +++ + KE+ + + + ++ L+ R+D+ +
Sbjct: 143 KEARKEAKEALEAKERYMEEMADTADAIEMATLDKEMAEERAESLQQEVEALKERVDELT 202
Query: 240 LDYSYARKRFDRAEAEYIAAKLDIQRKTEIKEQLTEHLCTIIQQNELRKAKKLEELMQQL 299
D + + ++ A+ +++ E +L + +++ +L ++K E + Q
Sbjct: 203 TDLEILKAEIEEKGSDGAASSYQLKQLEEQNARLKD---ALVRMRDLSSSEKQEHVKLQK 259
Query: 300 DVEADEETLELEVEVERLLHEQEVESRRPVVRLERPFQPA 339
+E + LE+ + L E+ ++ + L+ A
Sbjct: 260 LMEKKNQELEVVRQQRERLQEELSQAESTIDELKEQVDAA 299
Score = 42.4 bits (98), Expect = 7e-04
Identities = 51/206 (24%), Positives = 86/206 (41%), Gaps = 17/206 (8%)
Query: 133 KELGLENSHDGHNNVEILPPKPD---CKLEKKKVELQEK-SRWEVLQQEQRLMEEKNKRK 188
KE+ E + VE L + D LE K E++EK S + + +EE+N R
Sbjct: 177 KEMAEERAESLQQEVEALKERVDELTTDLEILKAEIEEKGSDGAASSYQLKQLEEQNARL 236
Query: 189 KALLAKAIAERSKRTQAETMKLKRIQKELQALDDMVSADIGILRNRIDQASLDYSYARKR 248
K L + S Q K ++K+ Q L+ ++R + ++ + S A
Sbjct: 237 KDALVRMRDLSSSEKQEHVKLQKLMEKKNQELE--------VVRQQRERLQEELSQAEST 288
Query: 249 FDRAEAEYIAAKLDIQRKTEIKEQLTEHLCTIIQQ-NELRKAKKLEELMQQLDVEADEET 307
D + E + A L + E+ E LT+ + ++ ELR+ E M +++ E E
Sbjct: 289 IDELK-EQVDAALGAE---EMVEMLTDRNLNLEEKVRELRETVGDLEAMNEMNDELQENA 344
Query: 308 LELEVEVERLLHEQEVESRRPVVRLE 333
E E+E+ L R R+E
Sbjct: 345 RETELELREQLDMAGARVREAQKRVE 370
>gi|41872583 Rho-associated, coiled-coil containing protein kinase 2
[Homo sapiens]
Length = 1388
Score = 53.5 bits (127), Expect = 3e-07
Identities = 59/264 (22%), Positives = 109/264 (41%), Gaps = 30/264 (11%)
Query: 124 QPQGIESQPKELGLENSHDGHNNVEILPPKPDCKLEKKKVELQEKSRWEVLQQEQRLMEE 183
Q ++ K+L EN+H + + + + E++ + Q K + L+ EQ
Sbjct: 816 QVNTLKMSEKQLKQENNHLMEMKMNLEKQNAELRKERQDADGQMKELQDQLEAEQ-YFST 874
Query: 184 KNKRKKALLAKAIAERSKRTQAETMKLKRIQKELQALDDMVSADIGILRNRIDQASLDYS 243
K + L + E++K + +L++ ++ELQ D ++A + I + D L S
Sbjct: 875 LYKTQVRELKEECEEKTKLGK----ELQQKKQELQDERDSLAAQLEITLTKADSEQLARS 930
Query: 244 YARKRFDRAEAEYIAAKLDI-QRKTEIKEQLTEHLCTIIQQNELRKA------------- 289
A +++ E E I +L+I + K++LTE TI E +
Sbjct: 931 IAEEQYSDLEKEKIMKELEIKEMMARHKQELTEKDATIASLEETNRTLTSDVANLANEKE 990
Query: 290 ---KKLEELMQQLDVEADEE--------TLELEVEVERLLHEQEVESRRPVVRLERPFQP 338
KL+++ +QL DEE E ++ ER L Q V ++ + P +
Sbjct: 991 ELNNKLKDVQEQLSRLKDEEISAAAIKAQFEKQLLTERTLKTQAVNKLAEIMNRKEPVKR 1050
Query: 339 AEESVTLEFAKENRKCQEQAVSPK 362
++ KENRK + S +
Sbjct: 1051 GNDTDVRRKEKENRKLHMELKSER 1074
Score = 35.8 bits (81), Expect = 0.069
Identities = 74/329 (22%), Positives = 131/329 (39%), Gaps = 58/329 (17%)
Query: 40 RLKQTKDPFEPQ--RRLPAKKSRQQLQREKALV-------------EQSQKLGLQDGSTS 84
RL++T E + R + + +QL+REKAL+ E +K L++ S
Sbjct: 476 RLEKTAKELEEEITLRKSVESALRQLEREKALLQHKNAEYQRKADHEADKKRNLENDVNS 535
Query: 85 LLPEQLLSAPKQRVNVQKPPFSSPTLPSHFTLTSPVGDGQPQGI--------ESQPKELG 136
L +QL K+ N Q L T+ + + ES +
Sbjct: 536 L-KDQLEDLKKRNQNSQISTEKVNQLQRQLDETNALLRTESDTAARLRKTQAESSKQIQQ 594
Query: 137 LENSHDGHNNVEILPPKPDCKLEKKKVELQEKSRWEV------------LQQEQRLMEEK 184
LE+++ + L KLEK+ + LQ E LQ +EE
Sbjct: 595 LESNNRDLQDKNCLLETAKLKLEKEFINLQSALESERRDRTHGSEIINDLQGRICGLEED 654
Query: 185 NKRKKALLAKAIAERSKRTQAETMKLKRIQKELQALDDMVSADIGILRNRIDQASLDYSY 244
K K LLAK E KR E + ++KE ++ ++ + +++ ++Q ++
Sbjct: 655 LKNGKILLAKV--ELEKRQLQE--RFTDLEKEKSNMEIDMTYQLKVIQQSLEQEEAEHKA 710
Query: 245 ARKRFDRAEAEYIA---AKLDIQRKTEIK-------EQLTEHL-------CTIIQQNELR 287
+ R Y + AK + ++ E K +Q E+L C+++ + +
Sbjct: 711 TKARLADKNKIYESIEEAKSEAMKEMEKKLLEERTLKQKVENLLLEAEKRCSLLDCDLKQ 770
Query: 288 KAKKLEELMQQLDV-EADEETLELEVEVE 315
+K+ EL++Q DV D L L++E E
Sbjct: 771 SQQKINELLKQKDVLNEDVRNLTLKIEQE 799
Score = 33.9 bits (76), Expect = 0.26
Identities = 39/178 (21%), Positives = 79/178 (44%), Gaps = 19/178 (10%)
Query: 155 DCKLEKKKVELQEKSRW-EVLQQEQR---LMEEKNKRKKALLAKAIAERSKRTQAETMKL 210
DC L++ + ++ E + +VL ++ R L E+ +K+ L + ++++ M
Sbjct: 765 DCDLKQSQQKINELLKQKDVLNEDVRNLTLKIEQETQKRCLTQNDLKMQTQQVNTLKMSE 824
Query: 211 KRIQKELQALDDM---VSADIGILRNRIDQASLDYSYARKRFDRAEAEYIAAKLDIQRKT 267
K++++E L +M + LR A ++ D+ EAE + L +
Sbjct: 825 KQLKQENNHLMEMKMNLEKQNAELRKERQDAD---GQMKELQDQLEAEQYFSTLYKTQVR 881
Query: 268 EIKEQLTEHLCTIIQQNELRKAKKLEELMQQLDVEADEETLELEVEVERLLHEQEVES 325
E+KE+ E + + K+L++ Q+L E D +LE+ + + EQ S
Sbjct: 882 ELKEECEE---------KTKLGKELQQKKQELQDERDSLAAQLEITLTKADSEQLARS 930
Score = 30.0 bits (66), Expect = 3.8
Identities = 38/192 (19%), Positives = 78/192 (40%), Gaps = 23/192 (11%)
Query: 137 LENSHDGHNNVEILPPKPDCKLEKKKVELQEKSRWEVLQQEQRLMEEKNKRKKALLAKAI 196
L N +E + +LEK EL+E+ L++ + +R+KALL
Sbjct: 456 LSNEMQAKEELEQKCKSVNTRLEKTAKELEEEI---TLRKSVESALRQLEREKALLQHKN 512
Query: 197 AERSKRTQAETMKLKRIQKELQALDDMV-------------SADIGILRNRIDQASL--- 240
AE ++ E K + ++ ++ +L D + + + L+ ++D+ +
Sbjct: 513 AEYQRKADHEADKKRNLENDVNSLKDQLEDLKKRNQNSQISTEKVNQLQRQLDETNALLR 572
Query: 241 DYSYARKRFDRAEAEYIAAKLDIQRKTEIKEQLTEHLCTIIQQNELRKAKKLEELMQQLD 300
S R + +AE + IQ+ L + C +++ +L+ K+ L L+
Sbjct: 573 TESDTAARLRKTQAE---SSKQIQQLESNNRDLQDKNC-LLETAKLKLEKEFINLQSALE 628
Query: 301 VEADEETLELEV 312
E + T E+
Sbjct: 629 SERRDRTHGSEI 640
>gi|68161546 misshapen/NIK-related kinase isoform 4 [Homo sapiens]
Length = 1312
Score = 53.1 bits (126), Expect = 4e-07
Identities = 53/264 (20%), Positives = 120/264 (45%), Gaps = 33/264 (12%)
Query: 129 ESQPKELGLENSHDGH------NNVEILPPKPDCKLEKKKVELQEKSRWEVLQQEQRLME 182
E++ + G E D H +++ +P + + E +++ + KS E L+Q+Q+L +
Sbjct: 318 ETEYEYSGSEEEDDSHGEEGEPSSIMNVPGESTLRREFLRLQQENKSNSEALKQQQQLQQ 377
Query: 183 EKNKRKKALLAKAIAERSKRTQAETMKLKRIQKELQALDDMVSADIGILRNRI-DQASLD 241
++ + +A + + +R +R + + + +R++++ + + + R+ D +L
Sbjct: 378 QQQRDPEAHIKHLLHQRQRRIEEQKEERRRVEEQQRREREQRKLQEKEQQRRLEDMQALR 437
Query: 242 YSYARKRFDRAEAEYIAAKLDIQRKTE-IKEQLTEHLCTIIQQNELRKAKKLEELMQQLD 300
R++ +R E EY +L+ QR++E ++ QL Q++ K+ + ++ QQL
Sbjct: 438 REEERRQAER-EQEYKRKQLEEQRQSERLQRQLQ-------QEHAYLKSLQQQQQQQQLQ 489
Query: 301 VEADEETLELEVEVERLLHEQEVESRRPVVRLERPFQPAEESVTLEFAKENRKCQEQAVS 360
+ ++ L + R+P+ R PA++ +E + +Q S
Sbjct: 490 KQQQQQLLPGD--------------RKPLYHYGRGMNPADKPAWAREVEERTRMNKQQNS 535
Query: 361 PKVDDQCGNSS---SIPFLSPNCP 381
P + G++ IP SP P
Sbjct: 536 PLAKSKPGSTGPEPPIPQASPGPP 559
>gi|24850117 misshapen/NIK-related kinase isoform 2 [Homo sapiens]
Length = 1303
Score = 53.1 bits (126), Expect = 4e-07
Identities = 53/264 (20%), Positives = 120/264 (45%), Gaps = 33/264 (12%)
Query: 129 ESQPKELGLENSHDGH------NNVEILPPKPDCKLEKKKVELQEKSRWEVLQQEQRLME 182
E++ + G E D H +++ +P + + E +++ + KS E L+Q+Q+L +
Sbjct: 318 ETEYEYSGSEEEDDSHGEEGEPSSIMNVPGESTLRREFLRLQQENKSNSEALKQQQQLQQ 377
Query: 183 EKNKRKKALLAKAIAERSKRTQAETMKLKRIQKELQALDDMVSADIGILRNRI-DQASLD 241
++ + +A + + +R +R + + + +R++++ + + + R+ D +L
Sbjct: 378 QQQRDPEAHIKHLLHQRQRRIEEQKEERRRVEEQQRREREQRKLQEKEQQRRLEDMQALR 437
Query: 242 YSYARKRFDRAEAEYIAAKLDIQRKTE-IKEQLTEHLCTIIQQNELRKAKKLEELMQQLD 300
R++ +R E EY +L+ QR++E ++ QL Q++ K+ + ++ QQL
Sbjct: 438 REEERRQAER-EQEYKRKQLEEQRQSERLQRQLQ-------QEHAYLKSLQQQQQQQQLQ 489
Query: 301 VEADEETLELEVEVERLLHEQEVESRRPVVRLERPFQPAEESVTLEFAKENRKCQEQAVS 360
+ ++ L + R+P+ R PA++ +E + +Q S
Sbjct: 490 KQQQQQLLPGD--------------RKPLYHYGRGMNPADKPAWAREVEERTRMNKQQNS 535
Query: 361 PKVDDQCGNSS---SIPFLSPNCP 381
P + G++ IP SP P
Sbjct: 536 PLAKSKPGSTGPEPPIPQASPGPP 559
>gi|27436917 misshapen/NIK-related kinase isoform 3 [Homo sapiens]
Length = 1332
Score = 53.1 bits (126), Expect = 4e-07
Identities = 53/264 (20%), Positives = 120/264 (45%), Gaps = 33/264 (12%)
Query: 129 ESQPKELGLENSHDGH------NNVEILPPKPDCKLEKKKVELQEKSRWEVLQQEQRLME 182
E++ + G E D H +++ +P + + E +++ + KS E L+Q+Q+L +
Sbjct: 318 ETEYEYSGSEEEDDSHGEEGEPSSIMNVPGESTLRREFLRLQQENKSNSEALKQQQQLQQ 377
Query: 183 EKNKRKKALLAKAIAERSKRTQAETMKLKRIQKELQALDDMVSADIGILRNRI-DQASLD 241
++ + +A + + +R +R + + + +R++++ + + + R+ D +L
Sbjct: 378 QQQRDPEAHIKHLLHQRQRRIEEQKEERRRVEEQQRREREQRKLQEKEQQRRLEDMQALR 437
Query: 242 YSYARKRFDRAEAEYIAAKLDIQRKTE-IKEQLTEHLCTIIQQNELRKAKKLEELMQQLD 300
R++ +R E EY +L+ QR++E ++ QL Q++ K+ + ++ QQL
Sbjct: 438 REEERRQAER-EQEYKRKQLEEQRQSERLQRQLQ-------QEHAYLKSLQQQQQQQQLQ 489
Query: 301 VEADEETLELEVEVERLLHEQEVESRRPVVRLERPFQPAEESVTLEFAKENRKCQEQAVS 360
+ ++ L + R+P+ R PA++ +E + +Q S
Sbjct: 490 KQQQQQLLPGD--------------RKPLYHYGRGMNPADKPAWAREVEERTRMNKQQNS 535
Query: 361 PKVDDQCGNSS---SIPFLSPNCP 381
P + G++ IP SP P
Sbjct: 536 PLAKSKPGSTGPEPPIPQASPGPP 559
>gi|7657335 misshapen/NIK-related kinase isoform 1 [Homo sapiens]
Length = 1295
Score = 53.1 bits (126), Expect = 4e-07
Identities = 53/264 (20%), Positives = 120/264 (45%), Gaps = 33/264 (12%)
Query: 129 ESQPKELGLENSHDGH------NNVEILPPKPDCKLEKKKVELQEKSRWEVLQQEQRLME 182
E++ + G E D H +++ +P + + E +++ + KS E L+Q+Q+L +
Sbjct: 318 ETEYEYSGSEEEDDSHGEEGEPSSIMNVPGESTLRREFLRLQQENKSNSEALKQQQQLQQ 377
Query: 183 EKNKRKKALLAKAIAERSKRTQAETMKLKRIQKELQALDDMVSADIGILRNRI-DQASLD 241
++ + +A + + +R +R + + + +R++++ + + + R+ D +L
Sbjct: 378 QQQRDPEAHIKHLLHQRQRRIEEQKEERRRVEEQQRREREQRKLQEKEQQRRLEDMQALR 437
Query: 242 YSYARKRFDRAEAEYIAAKLDIQRKTE-IKEQLTEHLCTIIQQNELRKAKKLEELMQQLD 300
R++ +R E EY +L+ QR++E ++ QL Q++ K+ + ++ QQL
Sbjct: 438 REEERRQAER-EQEYKRKQLEEQRQSERLQRQLQ-------QEHAYLKSLQQQQQQQQLQ 489
Query: 301 VEADEETLELEVEVERLLHEQEVESRRPVVRLERPFQPAEESVTLEFAKENRKCQEQAVS 360
+ ++ L + R+P+ R PA++ +E + +Q S
Sbjct: 490 KQQQQQLLPGD--------------RKPLYHYGRGMNPADKPAWAREVEERTRMNKQQNS 535
Query: 361 PKVDDQCGNSS---SIPFLSPNCP 381
P + G++ IP SP P
Sbjct: 536 PLAKSKPGSTGPEPPIPQASPGPP 559
>gi|156766047 GRB10 interacting GYF protein 2 isoform c [Homo
sapiens]
Length = 1293
Score = 52.4 bits (124), Expect = 7e-07
Identities = 67/294 (22%), Positives = 128/294 (43%), Gaps = 38/294 (12%)
Query: 51 QRRLPAKKSRQQLQREKALVEQSQKLGL---QDGSTSLLPEQLLSAPKQRVNVQKPPFSS 107
Q+ L A Q LQ ++ L++Q L Q + S +Q L+ Q+ K S
Sbjct: 607 QQELTALYQMQHLQYQQFLIQQQYAQVLAQQQKAALSSQQQQQLALLLQQFQTLKMRISD 666
Query: 108 PTLPSHFTLTSPVGDG----QPQGIESQPK--------ELGLENSHDGH--NNVEILPPK 153
+ T + V D + Q SQP +L L+ + G ++ L
Sbjct: 667 QNIIPSVTRSVSVPDTGSIWELQPTASQPTVWEGGSVWDLPLDTTTPGPALEQLQQLEKA 726
Query: 154 PDCKLEKKKVELQEKSRWEVLQQEQRLMEEKNKRKKALLAKAIAERSKRTQAETMKLKRI 213
KLE+++ E + +++ E +E+R +E+ +R++ + + E ++ + E +R
Sbjct: 727 KAAKLEQERREAEMRAKRE---EEERKRQEELRRQQEEILRRQQEEERKRREEEELARRK 783
Query: 214 QKELQALDDMVSADIGILRNRIDQASLDYSYARKRFDRAEAEYIAAKLDIQRKTEIKEQL 273
Q+E AL +I + R R ++ +R + E +L+ +R+ E + +
Sbjct: 784 QEE--ALRRQREQEIALRRQREEE------------ERQQQEEALRRLEERRREEEERRK 829
Query: 274 TEHLCTIIQQNELRKAKKLEELMQQLDVEADEETLELEVEVERLLHEQEVESRR 327
E L ++ + A++ EE ++L +E L +E E RL HE+E R+
Sbjct: 830 QEELLRKQEEEAAKWAREEEEAQRRL----EENRLRMEEEAARLRHEEEERKRK 879
Score = 36.2 bits (82), Expect = 0.053
Identities = 42/190 (22%), Positives = 90/190 (47%), Gaps = 14/190 (7%)
Query: 160 KKKVELQEKSRWEVLQQEQRLMEEKNKRKKALLAKAIAERSKRTQAETMKLKRIQKELQA 219
K++ L+ + E+ + QR EE+ ++++AL + + ER +R + E K + + ++ +
Sbjct: 783 KQEEALRRQREQEIALRRQREEEERQQQEEAL--RRLEER-RREEEERRKQEELLRKQEE 839
Query: 220 LDDMVSADIGILRNRIDQASLDYSYARKRFDRAEAEYIAAKLDIQRKTEI---KEQLTEH 276
+ + + R+++ L R E E +L++QR+ E+ ++Q E
Sbjct: 840 EAAKWAREEEEAQRRLEENRLRMEEEAARLRHEEEERKRKELEVQRQKELMRQRQQQQEA 899
Query: 277 LCTIIQQNELRKAKKLE-----ELMQQLDVEA--DEETLELEVEVERLLHEQEVESRRPV 329
L + QQ + ++ +++ QQ + A + TL L E+++L E+E + R
Sbjct: 900 LRRLQQQQQQQQLAQMKLPSSSTWGQQSNTTACQSQATLSL-AEIQKLEEERERQLREEQ 958
Query: 330 VRLERPFQPA 339
R +R A
Sbjct: 959 RRQQRELMKA 968
Score = 35.4 bits (80), Expect = 0.090
Identities = 32/100 (32%), Positives = 50/100 (50%), Gaps = 5/100 (5%)
Query: 245 ARKRFDRAEAEYIAAKLDIQRKT--EIKEQLTEHLCTIIQQNELRKAKKLEELMQQLDVE 302
A+ +R EAE A + + +RK E++ Q E L QQ E RK ++ EEL ++ E
Sbjct: 729 AKLEQERREAEMRAKREEEERKRQEELRRQQEEILRR--QQEEERKRREEEELARRKQEE 786
Query: 303 ADEETLELEVEVERLLHEQEVESRRPVV-RLERPFQPAEE 341
A E E+ + R E+E + + + RLE + EE
Sbjct: 787 ALRRQREQEIALRRQREEEERQQQEEALRRLEERRREEEE 826
Score = 33.9 bits (76), Expect = 0.26
Identities = 44/238 (18%), Positives = 104/238 (43%), Gaps = 32/238 (13%)
Query: 158 LEKKKVELQEKSRWEVLQ--QEQRLMEEKNKRKKALLAKAIAERSK-------------- 201
L +++ E + + + E L+ +E+R EE+ ++++ LL K E +K
Sbjct: 798 LRRQREEEERQQQEEALRRLEERRREEEERRKQEELLRKQEEEAAKWAREEEEAQRRLEE 857
Query: 202 ---RTQAETMKLKRIQKELQALDDMVSADIGILRNRIDQASLDYSYARKRFDRAEAEYIA 258
R + E +L+ ++E + + V ++R R Q A +R + + +
Sbjct: 858 NRLRMEEEAARLRHEEEERKRKELEVQRQKELMRQRQQQQE-----ALRRLQQQQQQQQL 912
Query: 259 AKLDIQRKTEIKEQLTEHLCTIIQQNELRKAKKLEELMQQLDVEADEETLELEVEVERLL 318
A++ + + +Q C L + +KLEE + + + EE + E+ + L
Sbjct: 913 AQMKLPSSSTWGQQSNTTACQSQATLSLAEIQKLEE---ERERQLREEQRRQQRELMKAL 969
Query: 319 HEQEVESRRPVVRLERPFQPAEESVTL-----EFAKENRKCQEQAVSPKVDDQCGNSS 371
+Q+ + ++ + +P+ + +L E A++ +K Q+Q + ++ N++
Sbjct: 970 QQQQQQQQQKLSGWGNVSKPSGTTKSLLEIQQEEARQMQKQQQQQQQHQQPNRARNNT 1027
Score = 30.0 bits (66), Expect = 3.8
Identities = 26/95 (27%), Positives = 43/95 (45%), Gaps = 16/95 (16%)
Query: 281 IQQNELRKAKKLEELMQQLDVEA----------------DEETLELEVEVERLLHEQEVE 324
+QQ E KA KLE+ ++ ++ A EE L + E ER E+E
Sbjct: 720 LQQLEKAKAAKLEQERREAEMRAKREEEERKRQEELRRQQEEILRRQQEEERKRREEEEL 779
Query: 325 SRRPVVRLERPFQPAEESVTLEFAKENRKCQEQAV 359
+RR R + E ++ + +E R+ QE+A+
Sbjct: 780 ARRKQEEALRRQREQEIALRRQREEEERQQQEEAL 814
>gi|156766045 GRB10 interacting GYF protein 2 isoform a [Homo
sapiens]
Length = 1320
Score = 52.4 bits (124), Expect = 7e-07
Identities = 67/294 (22%), Positives = 128/294 (43%), Gaps = 38/294 (12%)
Query: 51 QRRLPAKKSRQQLQREKALVEQSQKLGL---QDGSTSLLPEQLLSAPKQRVNVQKPPFSS 107
Q+ L A Q LQ ++ L++Q L Q + S +Q L+ Q+ K S
Sbjct: 634 QQELTALYQMQHLQYQQFLIQQQYAQVLAQQQKAALSSQQQQQLALLLQQFQTLKMRISD 693
Query: 108 PTLPSHFTLTSPVGDG----QPQGIESQPK--------ELGLENSHDGH--NNVEILPPK 153
+ T + V D + Q SQP +L L+ + G ++ L
Sbjct: 694 QNIIPSVTRSVSVPDTGSIWELQPTASQPTVWEGGSVWDLPLDTTTPGPALEQLQQLEKA 753
Query: 154 PDCKLEKKKVELQEKSRWEVLQQEQRLMEEKNKRKKALLAKAIAERSKRTQAETMKLKRI 213
KLE+++ E + +++ E +E+R +E+ +R++ + + E ++ + E +R
Sbjct: 754 KAAKLEQERREAEMRAKRE---EEERKRQEELRRQQEEILRRQQEEERKRREEEELARRK 810
Query: 214 QKELQALDDMVSADIGILRNRIDQASLDYSYARKRFDRAEAEYIAAKLDIQRKTEIKEQL 273
Q+E AL +I + R R ++ +R + E +L+ +R+ E + +
Sbjct: 811 QEE--ALRRQREQEIALRRQREEE------------ERQQQEEALRRLEERRREEEERRK 856
Query: 274 TEHLCTIIQQNELRKAKKLEELMQQLDVEADEETLELEVEVERLLHEQEVESRR 327
E L ++ + A++ EE ++L +E L +E E RL HE+E R+
Sbjct: 857 QEELLRKQEEEAAKWAREEEEAQRRL----EENRLRMEEEAARLRHEEEERKRK 906
Score = 36.2 bits (82), Expect = 0.053
Identities = 42/190 (22%), Positives = 90/190 (47%), Gaps = 14/190 (7%)
Query: 160 KKKVELQEKSRWEVLQQEQRLMEEKNKRKKALLAKAIAERSKRTQAETMKLKRIQKELQA 219
K++ L+ + E+ + QR EE+ ++++AL + + ER +R + E K + + ++ +
Sbjct: 810 KQEEALRRQREQEIALRRQREEEERQQQEEAL--RRLEER-RREEEERRKQEELLRKQEE 866
Query: 220 LDDMVSADIGILRNRIDQASLDYSYARKRFDRAEAEYIAAKLDIQRKTEI---KEQLTEH 276
+ + + R+++ L R E E +L++QR+ E+ ++Q E
Sbjct: 867 EAAKWAREEEEAQRRLEENRLRMEEEAARLRHEEEERKRKELEVQRQKELMRQRQQQQEA 926
Query: 277 LCTIIQQNELRKAKKLE-----ELMQQLDVEA--DEETLELEVEVERLLHEQEVESRRPV 329
L + QQ + ++ +++ QQ + A + TL L E+++L E+E + R
Sbjct: 927 LRRLQQQQQQQQLAQMKLPSSSTWGQQSNTTACQSQATLSL-AEIQKLEEERERQLREEQ 985
Query: 330 VRLERPFQPA 339
R +R A
Sbjct: 986 RRQQRELMKA 995
Score = 35.4 bits (80), Expect = 0.090
Identities = 32/100 (32%), Positives = 50/100 (50%), Gaps = 5/100 (5%)
Query: 245 ARKRFDRAEAEYIAAKLDIQRKT--EIKEQLTEHLCTIIQQNELRKAKKLEELMQQLDVE 302
A+ +R EAE A + + +RK E++ Q E L QQ E RK ++ EEL ++ E
Sbjct: 756 AKLEQERREAEMRAKREEEERKRQEELRRQQEEILRR--QQEEERKRREEEELARRKQEE 813
Query: 303 ADEETLELEVEVERLLHEQEVESRRPVV-RLERPFQPAEE 341
A E E+ + R E+E + + + RLE + EE
Sbjct: 814 ALRRQREQEIALRRQREEEERQQQEEALRRLEERRREEEE 853
Score = 33.9 bits (76), Expect = 0.26
Identities = 44/238 (18%), Positives = 104/238 (43%), Gaps = 32/238 (13%)
Query: 158 LEKKKVELQEKSRWEVLQ--QEQRLMEEKNKRKKALLAKAIAERSK-------------- 201
L +++ E + + + E L+ +E+R EE+ ++++ LL K E +K
Sbjct: 825 LRRQREEEERQQQEEALRRLEERRREEEERRKQEELLRKQEEEAAKWAREEEEAQRRLEE 884
Query: 202 ---RTQAETMKLKRIQKELQALDDMVSADIGILRNRIDQASLDYSYARKRFDRAEAEYIA 258
R + E +L+ ++E + + V ++R R Q A +R + + +
Sbjct: 885 NRLRMEEEAARLRHEEEERKRKELEVQRQKELMRQRQQQQE-----ALRRLQQQQQQQQL 939
Query: 259 AKLDIQRKTEIKEQLTEHLCTIIQQNELRKAKKLEELMQQLDVEADEETLELEVEVERLL 318
A++ + + +Q C L + +KLEE + + + EE + E+ + L
Sbjct: 940 AQMKLPSSSTWGQQSNTTACQSQATLSLAEIQKLEE---ERERQLREEQRRQQRELMKAL 996
Query: 319 HEQEVESRRPVVRLERPFQPAEESVTL-----EFAKENRKCQEQAVSPKVDDQCGNSS 371
+Q+ + ++ + +P+ + +L E A++ +K Q+Q + ++ N++
Sbjct: 997 QQQQQQQQQKLSGWGNVSKPSGTTKSLLEIQQEEARQMQKQQQQQQQHQQPNRARNNT 1054
Score = 30.0 bits (66), Expect = 3.8
Identities = 26/95 (27%), Positives = 43/95 (45%), Gaps = 16/95 (16%)
Query: 281 IQQNELRKAKKLEELMQQLDVEA----------------DEETLELEVEVERLLHEQEVE 324
+QQ E KA KLE+ ++ ++ A EE L + E ER E+E
Sbjct: 747 LQQLEKAKAAKLEQERREAEMRAKREEEERKRQEELRRQQEEILRRQQEEERKRREEEEL 806
Query: 325 SRRPVVRLERPFQPAEESVTLEFAKENRKCQEQAV 359
+RR R + E ++ + +E R+ QE+A+
Sbjct: 807 ARRKQEEALRRQREQEIALRRQREEEERQQQEEAL 841
>gi|156766043 GRB10 interacting GYF protein 2 isoform b [Homo
sapiens]
Length = 1299
Score = 52.4 bits (124), Expect = 7e-07
Identities = 67/294 (22%), Positives = 128/294 (43%), Gaps = 38/294 (12%)
Query: 51 QRRLPAKKSRQQLQREKALVEQSQKLGL---QDGSTSLLPEQLLSAPKQRVNVQKPPFSS 107
Q+ L A Q LQ ++ L++Q L Q + S +Q L+ Q+ K S
Sbjct: 613 QQELTALYQMQHLQYQQFLIQQQYAQVLAQQQKAALSSQQQQQLALLLQQFQTLKMRISD 672
Query: 108 PTLPSHFTLTSPVGDG----QPQGIESQPK--------ELGLENSHDGH--NNVEILPPK 153
+ T + V D + Q SQP +L L+ + G ++ L
Sbjct: 673 QNIIPSVTRSVSVPDTGSIWELQPTASQPTVWEGGSVWDLPLDTTTPGPALEQLQQLEKA 732
Query: 154 PDCKLEKKKVELQEKSRWEVLQQEQRLMEEKNKRKKALLAKAIAERSKRTQAETMKLKRI 213
KLE+++ E + +++ E +E+R +E+ +R++ + + E ++ + E +R
Sbjct: 733 KAAKLEQERREAEMRAKRE---EEERKRQEELRRQQEEILRRQQEEERKRREEEELARRK 789
Query: 214 QKELQALDDMVSADIGILRNRIDQASLDYSYARKRFDRAEAEYIAAKLDIQRKTEIKEQL 273
Q+E AL +I + R R ++ +R + E +L+ +R+ E + +
Sbjct: 790 QEE--ALRRQREQEIALRRQREEE------------ERQQQEEALRRLEERRREEEERRK 835
Query: 274 TEHLCTIIQQNELRKAKKLEELMQQLDVEADEETLELEVEVERLLHEQEVESRR 327
E L ++ + A++ EE ++L +E L +E E RL HE+E R+
Sbjct: 836 QEELLRKQEEEAAKWAREEEEAQRRL----EENRLRMEEEAARLRHEEEERKRK 885
Score = 36.2 bits (82), Expect = 0.053
Identities = 42/190 (22%), Positives = 90/190 (47%), Gaps = 14/190 (7%)
Query: 160 KKKVELQEKSRWEVLQQEQRLMEEKNKRKKALLAKAIAERSKRTQAETMKLKRIQKELQA 219
K++ L+ + E+ + QR EE+ ++++AL + + ER +R + E K + + ++ +
Sbjct: 789 KQEEALRRQREQEIALRRQREEEERQQQEEAL--RRLEER-RREEEERRKQEELLRKQEE 845
Query: 220 LDDMVSADIGILRNRIDQASLDYSYARKRFDRAEAEYIAAKLDIQRKTEI---KEQLTEH 276
+ + + R+++ L R E E +L++QR+ E+ ++Q E
Sbjct: 846 EAAKWAREEEEAQRRLEENRLRMEEEAARLRHEEEERKRKELEVQRQKELMRQRQQQQEA 905
Query: 277 LCTIIQQNELRKAKKLE-----ELMQQLDVEA--DEETLELEVEVERLLHEQEVESRRPV 329
L + QQ + ++ +++ QQ + A + TL L E+++L E+E + R
Sbjct: 906 LRRLQQQQQQQQLAQMKLPSSSTWGQQSNTTACQSQATLSL-AEIQKLEEERERQLREEQ 964
Query: 330 VRLERPFQPA 339
R +R A
Sbjct: 965 RRQQRELMKA 974
Score = 35.4 bits (80), Expect = 0.090
Identities = 32/100 (32%), Positives = 50/100 (50%), Gaps = 5/100 (5%)
Query: 245 ARKRFDRAEAEYIAAKLDIQRKT--EIKEQLTEHLCTIIQQNELRKAKKLEELMQQLDVE 302
A+ +R EAE A + + +RK E++ Q E L QQ E RK ++ EEL ++ E
Sbjct: 735 AKLEQERREAEMRAKREEEERKRQEELRRQQEEILRR--QQEEERKRREEEELARRKQEE 792
Query: 303 ADEETLELEVEVERLLHEQEVESRRPVV-RLERPFQPAEE 341
A E E+ + R E+E + + + RLE + EE
Sbjct: 793 ALRRQREQEIALRRQREEEERQQQEEALRRLEERRREEEE 832
Score = 33.9 bits (76), Expect = 0.26
Identities = 44/238 (18%), Positives = 104/238 (43%), Gaps = 32/238 (13%)
Query: 158 LEKKKVELQEKSRWEVLQ--QEQRLMEEKNKRKKALLAKAIAERSK-------------- 201
L +++ E + + + E L+ +E+R EE+ ++++ LL K E +K
Sbjct: 804 LRRQREEEERQQQEEALRRLEERRREEEERRKQEELLRKQEEEAAKWAREEEEAQRRLEE 863
Query: 202 ---RTQAETMKLKRIQKELQALDDMVSADIGILRNRIDQASLDYSYARKRFDRAEAEYIA 258
R + E +L+ ++E + + V ++R R Q A +R + + +
Sbjct: 864 NRLRMEEEAARLRHEEEERKRKELEVQRQKELMRQRQQQQE-----ALRRLQQQQQQQQL 918
Query: 259 AKLDIQRKTEIKEQLTEHLCTIIQQNELRKAKKLEELMQQLDVEADEETLELEVEVERLL 318
A++ + + +Q C L + +KLEE + + + EE + E+ + L
Sbjct: 919 AQMKLPSSSTWGQQSNTTACQSQATLSLAEIQKLEE---ERERQLREEQRRQQRELMKAL 975
Query: 319 HEQEVESRRPVVRLERPFQPAEESVTL-----EFAKENRKCQEQAVSPKVDDQCGNSS 371
+Q+ + ++ + +P+ + +L E A++ +K Q+Q + ++ N++
Sbjct: 976 QQQQQQQQQKLSGWGNVSKPSGTTKSLLEIQQEEARQMQKQQQQQQQHQQPNRARNNT 1033
Score = 30.0 bits (66), Expect = 3.8
Identities = 26/95 (27%), Positives = 43/95 (45%), Gaps = 16/95 (16%)
Query: 281 IQQNELRKAKKLEELMQQLDVEA----------------DEETLELEVEVERLLHEQEVE 324
+QQ E KA KLE+ ++ ++ A EE L + E ER E+E
Sbjct: 726 LQQLEKAKAAKLEQERREAEMRAKREEEERKRQEELRRQQEEILRRQQEEERKRREEEEL 785
Query: 325 SRRPVVRLERPFQPAEESVTLEFAKENRKCQEQAV 359
+RR R + E ++ + +E R+ QE+A+
Sbjct: 786 ARRKQEEALRRQREQEIALRRQREEEERQQQEEAL 820
>gi|42476299 GRB10 interacting GYF protein 2 isoform b [Homo
sapiens]
Length = 1299
Score = 52.4 bits (124), Expect = 7e-07
Identities = 67/294 (22%), Positives = 128/294 (43%), Gaps = 38/294 (12%)
Query: 51 QRRLPAKKSRQQLQREKALVEQSQKLGL---QDGSTSLLPEQLLSAPKQRVNVQKPPFSS 107
Q+ L A Q LQ ++ L++Q L Q + S +Q L+ Q+ K S
Sbjct: 613 QQELTALYQMQHLQYQQFLIQQQYAQVLAQQQKAALSSQQQQQLALLLQQFQTLKMRISD 672
Query: 108 PTLPSHFTLTSPVGDG----QPQGIESQPK--------ELGLENSHDGH--NNVEILPPK 153
+ T + V D + Q SQP +L L+ + G ++ L
Sbjct: 673 QNIIPSVTRSVSVPDTGSIWELQPTASQPTVWEGGSVWDLPLDTTTPGPALEQLQQLEKA 732
Query: 154 PDCKLEKKKVELQEKSRWEVLQQEQRLMEEKNKRKKALLAKAIAERSKRTQAETMKLKRI 213
KLE+++ E + +++ E +E+R +E+ +R++ + + E ++ + E +R
Sbjct: 733 KAAKLEQERREAEMRAKRE---EEERKRQEELRRQQEEILRRQQEEERKRREEEELARRK 789
Query: 214 QKELQALDDMVSADIGILRNRIDQASLDYSYARKRFDRAEAEYIAAKLDIQRKTEIKEQL 273
Q+E AL +I + R R ++ +R + E +L+ +R+ E + +
Sbjct: 790 QEE--ALRRQREQEIALRRQREEE------------ERQQQEEALRRLEERRREEEERRK 835
Query: 274 TEHLCTIIQQNELRKAKKLEELMQQLDVEADEETLELEVEVERLLHEQEVESRR 327
E L ++ + A++ EE ++L +E L +E E RL HE+E R+
Sbjct: 836 QEELLRKQEEEAAKWAREEEEAQRRL----EENRLRMEEEAARLRHEEEERKRK 885
Score = 36.2 bits (82), Expect = 0.053
Identities = 42/190 (22%), Positives = 90/190 (47%), Gaps = 14/190 (7%)
Query: 160 KKKVELQEKSRWEVLQQEQRLMEEKNKRKKALLAKAIAERSKRTQAETMKLKRIQKELQA 219
K++ L+ + E+ + QR EE+ ++++AL + + ER +R + E K + + ++ +
Sbjct: 789 KQEEALRRQREQEIALRRQREEEERQQQEEAL--RRLEER-RREEEERRKQEELLRKQEE 845
Query: 220 LDDMVSADIGILRNRIDQASLDYSYARKRFDRAEAEYIAAKLDIQRKTEI---KEQLTEH 276
+ + + R+++ L R E E +L++QR+ E+ ++Q E
Sbjct: 846 EAAKWAREEEEAQRRLEENRLRMEEEAARLRHEEEERKRKELEVQRQKELMRQRQQQQEA 905
Query: 277 LCTIIQQNELRKAKKLE-----ELMQQLDVEA--DEETLELEVEVERLLHEQEVESRRPV 329
L + QQ + ++ +++ QQ + A + TL L E+++L E+E + R
Sbjct: 906 LRRLQQQQQQQQLAQMKLPSSSTWGQQSNTTACQSQATLSL-AEIQKLEEERERQLREEQ 964
Query: 330 VRLERPFQPA 339
R +R A
Sbjct: 965 RRQQRELMKA 974
Score = 35.4 bits (80), Expect = 0.090
Identities = 32/100 (32%), Positives = 50/100 (50%), Gaps = 5/100 (5%)
Query: 245 ARKRFDRAEAEYIAAKLDIQRKT--EIKEQLTEHLCTIIQQNELRKAKKLEELMQQLDVE 302
A+ +R EAE A + + +RK E++ Q E L QQ E RK ++ EEL ++ E
Sbjct: 735 AKLEQERREAEMRAKREEEERKRQEELRRQQEEILRR--QQEEERKRREEEELARRKQEE 792
Query: 303 ADEETLELEVEVERLLHEQEVESRRPVV-RLERPFQPAEE 341
A E E+ + R E+E + + + RLE + EE
Sbjct: 793 ALRRQREQEIALRRQREEEERQQQEEALRRLEERRREEEE 832
Score = 33.9 bits (76), Expect = 0.26
Identities = 44/238 (18%), Positives = 104/238 (43%), Gaps = 32/238 (13%)
Query: 158 LEKKKVELQEKSRWEVLQ--QEQRLMEEKNKRKKALLAKAIAERSK-------------- 201
L +++ E + + + E L+ +E+R EE+ ++++ LL K E +K
Sbjct: 804 LRRQREEEERQQQEEALRRLEERRREEEERRKQEELLRKQEEEAAKWAREEEEAQRRLEE 863
Query: 202 ---RTQAETMKLKRIQKELQALDDMVSADIGILRNRIDQASLDYSYARKRFDRAEAEYIA 258
R + E +L+ ++E + + V ++R R Q A +R + + +
Sbjct: 864 NRLRMEEEAARLRHEEEERKRKELEVQRQKELMRQRQQQQE-----ALRRLQQQQQQQQL 918
Query: 259 AKLDIQRKTEIKEQLTEHLCTIIQQNELRKAKKLEELMQQLDVEADEETLELEVEVERLL 318
A++ + + +Q C L + +KLEE + + + EE + E+ + L
Sbjct: 919 AQMKLPSSSTWGQQSNTTACQSQATLSLAEIQKLEE---ERERQLREEQRRQQRELMKAL 975
Query: 319 HEQEVESRRPVVRLERPFQPAEESVTL-----EFAKENRKCQEQAVSPKVDDQCGNSS 371
+Q+ + ++ + +P+ + +L E A++ +K Q+Q + ++ N++
Sbjct: 976 QQQQQQQQQKLSGWGNVSKPSGTTKSLLEIQQEEARQMQKQQQQQQQHQQPNRARNNT 1033
Score = 30.0 bits (66), Expect = 3.8
Identities = 26/95 (27%), Positives = 43/95 (45%), Gaps = 16/95 (16%)
Query: 281 IQQNELRKAKKLEELMQQLDVEA----------------DEETLELEVEVERLLHEQEVE 324
+QQ E KA KLE+ ++ ++ A EE L + E ER E+E
Sbjct: 726 LQQLEKAKAAKLEQERREAEMRAKREEEERKRQEELRRQQEEILRRQQEEERKRREEEEL 785
Query: 325 SRRPVVRLERPFQPAEESVTLEFAKENRKCQEQAV 359
+RR R + E ++ + +E R+ QE+A+
Sbjct: 786 ARRKQEEALRRQREQEIALRRQREEEERQQQEEAL 820
>gi|115648142 centrosomal protein 164kDa [Homo sapiens]
Length = 1460
Score = 51.6 bits (122), Expect = 1e-06
Identities = 65/275 (23%), Positives = 121/275 (44%), Gaps = 43/275 (15%)
Query: 94 PKQRVNVQKPPFSSPTLPSHFTLTSPVGDGQPQGIESQPKELGLENSHDGHNNV------ 147
P+++V V P SP + S T PV + Q E L+ + V
Sbjct: 559 PEEKVAVSPTPPVSPEVRS----TEPVAPPE------QLSEAALKAMEEAVAQVLEQDQR 608
Query: 148 EILPPKPDCKLEKKKVELQEKSRWEVL----QQEQRLMEEKNKRKKALLAKAIAERSKRT 203
+L K + K+++ + +L ++ E+L Q+EQ L + + +KA+ + R + +
Sbjct: 609 HLLESKQE-KMQQLREKLCQEEEEEILRLHQQKEQSLSSLRERLQKAIEEEEARMREEES 667
Query: 204 QAETMKLKRIQKELQALDDMVSADIGILRNRIDQASLDYSYARKRFDRAEAEYIAAKLDI 263
Q + ++Q QA +D + A+ +ASL +K + E++ A + +
Sbjct: 668 QRLSWLRAQVQSSTQADEDQIRAE--------QEASL-----QKLREELESQQKAERASL 714
Query: 264 QRKT-EIKEQLTEHLCTIIQQNE----LRKAKKLEELMQQLDVEADEETLELE----VEV 314
++K ++ EQL E + + + K K L++L +QL+ E E LE E+
Sbjct: 715 EQKNRQMLEQLKEEIEASEKSEQAALNAAKEKALQQLREQLEGERKEAVATLEKEHSAEL 774
Query: 315 ERLLHEQEVESRRPVVRLERPFQPAEESVTLEFAK 349
ERL E + R V L++ Q A++ + K
Sbjct: 775 ERLCSSLEAKHREVVSSLQKKIQEAQQKEEAQLQK 809
Score = 35.4 bits (80), Expect = 0.090
Identities = 71/324 (21%), Positives = 130/324 (40%), Gaps = 43/324 (13%)
Query: 35 EEELRRLKQTKDPFEPQRRLPAKKSRQQLQREKALVEQSQKLG---LQDGSTSLLPEQLL 91
EEE+ RL Q K+ R +K+ ++ + + E+SQ+L Q S++ E +
Sbjct: 630 EEEILRLHQQKEQSLSSLRERLQKAIEE-EEARMREEESQRLSWLRAQVQSSTQADEDQI 688
Query: 92 SAPKQRVNVQKPPFSSPTLPSHFTLTSPVGDGQPQGIESQPKELGLENSHDGHNNVEILP 151
A +Q ++QK + +ESQ K +E L
Sbjct: 689 RA-EQEASLQK---------------------LREELESQQKAERASLEQKNRQMLEQLK 726
Query: 152 PKPDCKLEKKKVELQEKSRWEVLQQEQRLMEEKNKRKKALLAK---AIAER------SKR 202
+ + EK + ++ + LQQ + +E + K A L K A ER +K
Sbjct: 727 EEIEAS-EKSEQAALNAAKEKALQQLREQLEGERKEAVATLEKEHSAELERLCSSLEAKH 785
Query: 203 TQAETMKLKRIQKELQALDDMVSADIGILRNRIDQASLD---YSYARKRFDRAEAEYIAA 259
+ + K+IQ+ Q + + +G + +R+ Q S Y + R + + +
Sbjct: 786 REVVSSLQKKIQEAQQKEEAQLQKCLGQVEHRVHQKSYHVAGYEHELSSLLREKRQEVEG 845
Query: 260 KLDIQRKTEIKEQLTEHLCTIIQQNELRKAKKLEELMQQLDVEADEETLELEVEVERLLH 319
+ + +R ++KE+ + + +Q E + K+ EL+ L E + E E+E +
Sbjct: 846 EHE-RRLDKMKEEHQQVMAKAREQYEAEERKQRAELLGHLTGELERLQRAHERELETVRQ 904
Query: 320 EQE---VESRRPVVRLERPFQPAE 340
EQ + RR ER Q E
Sbjct: 905 EQHKRLEDLRRRHREQERKLQDLE 928
Score = 32.7 bits (73), Expect = 0.58
Identities = 43/206 (20%), Positives = 92/206 (44%), Gaps = 30/206 (14%)
Query: 155 DCKLEKKKVELQEKSRWEVLQQEQRLMEEKNKRKKALLAKAIAERSKRTQAETMKLKRIQ 214
+ L+K + EL+ + + E+ +E+KN++ L + I K QA K +
Sbjct: 693 EASLQKLREELESQQK-----AERASLEQKNRQMLEQLKEEIEASEKSEQAALNAAK--E 745
Query: 215 KELQALDDMVSADIGILRNRIDQASLDYSYARKRFDRAEAEYIAAKLDIQRKTEIKEQLT 274
K LQ L + + + + A+L+ ++ AE E + + L+ + + ++
Sbjct: 746 KALQQLREQLEGE-----RKEAVATLEKEHS------AELERLCSSLEAKHR-----EVV 789
Query: 275 EHLCTIIQQNELRKAKKLEELMQQLDVEADEETLEL---EVEVERLLHE--QEVES--RR 327
L IQ+ + ++ +L++ + Q++ +++ + E E+ LL E QEVE R
Sbjct: 790 SSLQKKIQEAQQKEEAQLQKCLGQVEHRVHQKSYHVAGYEHELSSLLREKRQEVEGEHER 849
Query: 328 PVVRLERPFQPAEESVTLEFAKENRK 353
+ +++ Q ++ E RK
Sbjct: 850 RLDKMKEEHQQVMAKAREQYEAEERK 875
>gi|41327691 kinesin-like motor protein C20orf23 [Homo sapiens]
Length = 1317
Score = 49.7 bits (117), Expect = 5e-06
Identities = 49/190 (25%), Positives = 95/190 (50%), Gaps = 18/190 (9%)
Query: 164 ELQEKSRWEVLQQEQRLMEEKNKRKKALLAKAIAERSKRTQAETMKLKRIQKELQALDDM 223
E Q++ E L+ +++L+EE +++K+ KA ER ++ + ET + KE + +
Sbjct: 599 ERQQREELEKLESKRKLIEEMEEKQKS--DKAELERMQQ-EVETQR-----KETEIVQLQ 650
Query: 224 VSADIGILRNR---IDQASLDYSYARKRFDRAEAEYIAAKLDIQRKTEIKE---QLTEHL 277
+ L+ R I+ D +++F+ ++++Q+K + +E ++ E L
Sbjct: 651 IRKQEESLKRRSFHIENKLKDLLAEKEKFEEERLRE-QQEIELQKKRQEEETFLRVQEEL 709
Query: 278 CTIIQQNELRKAKKLE--ELMQQLDVEADEETLELEVEVERLLHEQEVESRRPVVRLERP 335
+ + N KA+K + + + QL E DE+ +LE+E +R L EQE E V LE
Sbjct: 710 QRLKELNNNEKAEKFQIFQELDQLQKEKDEQYAKLELEKKR-LEEQEKEQVMLVAHLEEQ 768
Query: 336 FQPAEESVTL 345
+ +E + L
Sbjct: 769 LREKQEMIQL 778
Score = 37.0 bits (84), Expect = 0.031
Identities = 42/204 (20%), Positives = 92/204 (45%), Gaps = 33/204 (16%)
Query: 126 QGIESQPKELGLENSHDGHNNVEILPPKPDCKLEKKKVELQEKSRWEVLQQEQRLMEEKN 185
Q +E+Q KE + V++ K + L+++ ++ K + ++L ++++ EE+
Sbjct: 635 QEVETQRKETEI---------VQLQIRKQEESLKRRSFHIENKLK-DLLAEKEKFEEERL 684
Query: 186 KRKKAL-LAKAIAERSK--RTQAETMKLKRIQKELQALDDMVSADIGILRNRIDQASLDY 242
+ ++ + L K E R Q E +LK + +A + ++ L+ D+
Sbjct: 685 REQQEIELQKKRQEEETFLRVQEELQRLKELNNNEKAEKFQIFQELDQLQKEKDEQYAKL 744
Query: 243 SYARKRFDRAEAEYIAAKLDIQRKTEIKEQLTEHLCTIIQQNELRKAKKLEELMQQLDVE 302
+KR + E E + L HL + +LR+ +++ +L+++ +V+
Sbjct: 745 ELEKKRLEEQEKEQV--------------MLVAHL-----EEQLREKQEMIQLLRRGEVQ 785
Query: 303 -ADEETLELEVEVERLLHEQEVES 325
+EE +LE E LL +E +
Sbjct: 786 WVEEEKRDLEGIRESLLRVKEARA 809
Score = 35.8 bits (81), Expect = 0.069
Identities = 47/212 (22%), Positives = 93/212 (43%), Gaps = 42/212 (19%)
Query: 160 KKKVELQEKSRWEVLQQEQRLMEEKNKRKKALLAKAIA------ERSKRTQAETMKLKRI 213
K+ +L+EK + +L M + +K ++ L A + ER +R + E ++ KR
Sbjct: 555 KEAAKLREKRKSGLLSSFSLSMTDLSKSRENLSAVMLYNPGLEFERQQREELEKLESKR- 613
Query: 214 QKELQALDDMVSADIGILRNRIDQASLDYSYARKRFDRAEAEYIAAKLDIQRK-TEIKEQ 272
K ++ +++ +++ D+AE E + +++ QRK TEI +
Sbjct: 614 -KLIEEMEE-----------------------KQKSDKAELERMQQEVETQRKETEIVQ- 648
Query: 273 LTEHLCTIIQQNELRKAKKLEELMQQLDVEADEETLELEVEVERLLHEQEVESRRPVVRL 332
I +Q E K + + D+ A++E + E ERL +QE+E ++
Sbjct: 649 -----LQIRKQEESLKRRSFHIENKLKDLLAEKE----KFEEERLREQQEIELQKKRQEE 699
Query: 333 ERPFQPAEESVTLEFAKENRKCQEQAVSPKVD 364
E + EE L+ N K ++ + ++D
Sbjct: 700 ETFLRVQEELQRLKELNNNEKAEKFQIFQELD 731
>gi|95147555 microtubule-associated protein 1A [Homo sapiens]
Length = 2803
Score = 49.3 bits (116), Expect = 6e-06
Identities = 58/212 (27%), Positives = 95/212 (44%), Gaps = 36/212 (16%)
Query: 131 QPKELGLENSHDGHNNVEILPPKPDCKLEKKKVELQEKSRW-----EVLQQEQRLMEEKN 185
+PK+ LE + +P + D LE+K L++K + + L+Q+ R++E+K
Sbjct: 1430 EPKDKDLEEKDKALEQKDKIPEEKDKALEQKDTALEQKDKALEPKDKDLEQKDRVLEQKE 1489
Query: 186 K----RKKALLAK-----------AIAERSKRTQAETMKLKRIQKELQALDDMVSADIGI 230
K + KAL K +AE R +T K + + Q D VS
Sbjct: 1490 KIPEEKDKALDQKVRSVEHKAPEDTVAEMKDRDLEQTDKAPEQKHQAQEQKDKVS----- 1544
Query: 231 LRNRIDQASLDYSYARKRFDRAEAEYIAAKLDIQRKTEIKEQLTEHLCTIIQQNELRKAK 290
+ DQA +A + D A + I A L+ +T+ +E L +Q+++ RK K
Sbjct: 1545 --EKKDQALEQKYWALGQKDEALEQNIQA-LEENHQTQEQESL-------VQEDKTRKPK 1594
Query: 291 KLEELMQQLDVEADEETLELEVEVERLLHEQE 322
LEE + V+A EE LE +E + L +E
Sbjct: 1595 MLEEKSPE-KVKAMEEKLEALLEKTKALGLEE 1625
Score = 30.4 bits (67), Expect = 2.9
Identities = 26/172 (15%), Positives = 79/172 (45%), Gaps = 3/172 (1%)
Query: 160 KKKVELQEKSRWEVLQQEQRLMEEKNKRKKALLAKAIAERSKRTQAETMKLKRIQKELQA 219
K+ ++ K+ L + + ++EE K ++ LAK +A+ K+ + + K + +
Sbjct: 320 KESLKATTKTAVSKLAKREEVVEEGAKEARSELAKELAKTEKKAKESSEKPPEKPAKPER 379
Query: 220 LDDMVSADIGILRNRIDQASLDYSYARKRFDRAEAEYIAAKLDIQRKTEIKEQLTEHLCT 279
+ S + + ++ + + + +++ + E + K +I+++ +++L +
Sbjct: 380 VKTESSEALKAEKRKLIKDKVGKKHLKEKISKLEEKKDKEKKEIKKE---RKELKKDEGR 436
Query: 280 IIQQNELRKAKKLEELMQQLDVEADEETLELEVEVERLLHEQEVESRRPVVR 331
++ + +K +K ++ +L + + EV + L++ +V R + R
Sbjct: 437 KEEKKDAKKEEKRKDTKPELKKISKPDLKPFTPEVRKTLYKAKVPGRVKIDR 488
>gi|148746195 trichohyalin [Homo sapiens]
Length = 1943
Score = 48.5 bits (114), Expect = 1e-05
Identities = 71/355 (20%), Positives = 141/355 (39%), Gaps = 30/355 (8%)
Query: 35 EEELRRLKQTKDPFEPQRRLPAKKSRQQLQREKALVEQSQKLGLQDGSTSLLPEQ-LLSA 93
EE+L R ++ K + R KK Q + E+ L E+ +K LQ+ E+ L
Sbjct: 1000 EEQLLREEREKRRRQEWERQYRKKDELQQEEEQLLREEREKRRLQERERQYREEEELQQE 1059
Query: 94 PKQRVNVQKPPFSSPTLPSHFTLTSPVGDGQPQGIESQP-------KELGLENSHDGHNN 146
+Q + ++ L + + + Q + +P +E +
Sbjct: 1060 EEQLLGEERETRRRQELERQYRKEEELQQEEEQLLREEPEKRRRQERERQCREEEELQQE 1119
Query: 147 VEILPPKPDCKLEKKKVELQEKSRWEVLQQEQRLM-EEKNKRKKALLAKAIAERSKRTQA 205
E L + K ++++E Q + EV Q+E++L+ EE KR++ L + E + Q
Sbjct: 1120 EEQLLREEREKRRRQELERQYREEEEVQQEEEQLLREEPEKRRRQELERQYREEEELQQE 1179
Query: 206 ETMKLKRIQ-KELQALDDMVSADIGILRNRIDQ--------ASLDYSYARKRFDRA---- 252
E L+ Q K Q + + + R + Q + L + + ++ +
Sbjct: 1180 EEQLLREEQEKRRQERERQYREEEELQRQKRKQRYRDEDQRSDLKWQWEPEKENAVRDNK 1239
Query: 253 ------EAEYIAAKLDIQRKTEIKEQLTEHLCTIIQQNELRKAKKLEELMQQLDVEADEE 306
E E D Q + +Q +HL + +Q E + ++ Q+ +EE
Sbjct: 1240 VYCKGRENEQFRQLEDSQLRDRQSQQDLQHL--LGEQQERDREQERRRWQQRDRHFPEEE 1297
Query: 307 TLELEVEVERLLHEQEVESRRPVVRLERPFQPAEESVTLEFAKENRKCQEQAVSP 361
LE E + E +++ + + ++R ER + + +F +E + QE+ P
Sbjct: 1298 QLEREEQKEAKRRDRKSQEEKQLLREEREEKRRRQETDRKFREEEQLLQEREEQP 1352
Score = 48.1 bits (113), Expect = 1e-05
Identities = 49/209 (23%), Positives = 95/209 (45%), Gaps = 9/209 (4%)
Query: 161 KKVELQE--KSRWEVLQQEQRLMEEKNKRKKALLAKAIAERSKRTQAETMKLKRIQKELQ 218
+K+E QE + R E QQ+QRL E+ R+K + + +R Q E + + ++E Q
Sbjct: 279 RKLERQELRRERQEEEQQQQRLRREQQLRRKQEEERREQQEERREQQERREQQEERREQQ 338
Query: 219 ALDDMVSADIGILRNRIDQASLDYSYARKRFDRAEAEYIAAKLDIQRKTEI-KEQLTEHL 277
+ LR ++ + R++ + + + + ++R+ ++ +EQ
Sbjct: 339 LRREQEERREQQLRREQEEERREQQLRREQEEERREQQLRREQQLRREQQLRREQQLRRE 398
Query: 278 CTIIQQNELRKAKKLEELMQQLDVEADEETLELEVEVERLLHEQEVESRRPVVRLERPFQ 337
+ ++ +LR+ ++L QQL E+ L E E ER HEQ+ E R RL+R +
Sbjct: 399 QQLRREQQLRREQQLRR-EQQL---RREQQLRREQEEER--HEQKHEQERREQRLKREQE 452
Query: 338 PAEESVTLEFAKENRKCQEQAVSPKVDDQ 366
+ + E E + + + K D +
Sbjct: 453 ERRDWLKREEETERHEQERRKQQLKRDQE 481
Score = 47.4 bits (111), Expect = 2e-05
Identities = 72/342 (21%), Positives = 147/342 (42%), Gaps = 34/342 (9%)
Query: 33 FSEEELRRLKQTKDPFEPQRRLPAKKSRQQLQR-EKALVEQSQKLGLQDGSTSLLPEQLL 91
F EE + ++ + E ++ L + +QLQR E+A Q ++ GLQ+ ++
Sbjct: 810 FLPEEEEKEQRRRQRREREKELQFLEEEEQLQRRERAQQLQEEEDGLQEDQERRRSQEQR 869
Query: 92 SAPKQRVNVQKPP-------FSSPTLPSHFTLTSPVGDGQPQGIESQPKELGLENSHDGH 144
K R +++ ++ P L + Q ++ + +EL E
Sbjct: 870 RDQKWRWQLEEERKRRRHTLYAKPALQEQLRK-------EQQLLQEEEEELQREEREKRR 922
Query: 145 NNVEILPPKPDCKLEKKKVELQEKSRWEVLQQEQRLMEEKNKRKKALLAKAIAER-SKRT 203
+ + + +L++++ +L + R + +QE+ K+K+ + + + E KR
Sbjct: 923 RQEQERQYREEEQLQQEEEQLLREEREKRRRQERERQYRKDKKLQQKEEQLLGEEPEKRR 982
Query: 204 QAETMKLKRIQKELQALDDMVSADIGILRNRIDQASLDYSYARKRFDRAEAEYIAAKLDI 263
+ E K R ++ELQ ++ + + R + + + Y +K + E E + +
Sbjct: 983 RQEREKKYREEEELQQEEEQLLRE---EREKRRRQEWERQYRKKDELQQEEEQLLREERE 1039
Query: 264 QRKTEIKEQLTEHLCTIIQQNEL-----RKAKKLEELMQQLDVEADEETLELEVEVERLL 318
+R+ + +E+ + Q+ E R+ ++ +EL +Q E EL+ E E+LL
Sbjct: 1040 KRRLQERERQYREEEELQQEEEQLLGEERETRRRQELERQYRKEE-----ELQQEEEQLL 1094
Query: 319 HEQEVESRRP----VVRLERPFQPAEESVTLEFAKENRKCQE 356
E+ + RR R E Q EE + E +E R+ QE
Sbjct: 1095 REEPEKRRRQERERQCREEEELQQEEEQLLRE-EREKRRRQE 1135
Score = 46.2 bits (108), Expect = 5e-05
Identities = 72/367 (19%), Positives = 154/367 (41%), Gaps = 45/367 (12%)
Query: 35 EEELRRLKQTKDPFEPQRRLPAKKSRQQLQREKALVEQSQKLGLQDGSTSLLPEQLLSAP 94
E++LRR ++ + + +R ++ QQL+RE+ + Q+L + L EQ L
Sbjct: 336 EQQLRREQEERREQQLRREQEEERREQQLRREQEEERREQQLRREQ---QLRREQQLRR- 391
Query: 95 KQRVNVQKPPFSSPTLPSHFTLTSPVGDGQPQGIESQPKELGLENSHDGHNNVEILPPKP 154
+Q++ ++ L L + Q + + +E E H+ + L +
Sbjct: 392 EQQLRREQQLRREQQLRREQQLRREQQLRREQQLRREQEEERHEQKHEQERREQRLKREQ 451
Query: 155 DCKLE--------------------KKKVELQEKSRWEVLQQEQRLMEEKNKRKKALLAK 194
+ + + K+ E + + RW L++E+R E+ +R++ L +
Sbjct: 452 EERRDWLKREEETERHEQERRKQQLKRDQEEERRERWLKLEEEER--REQQERREQQLRR 509
Query: 195 AIAERS----KRTQAETMKLKRIQKELQALDDMVSADIGILRNRIDQASLDYSYARKRFD 250
ER KR + E +R++ E Q + +L+ R ++ L+ +R
Sbjct: 510 EQEERREQRLKRQEEEERLQQRLRSEQQLRREQEERREQLLK-REEEKRLEQERREQRLK 568
Query: 251 RAEAE---YIAAKLDIQRKTEIKEQLTEHLCTIIQQNELRKAKKLEELMQQLDVEADEE- 306
R + E + + + +R+ +K + E L +++ E+ + ++ E Q+L E EE
Sbjct: 569 REQEERRDQLLKREEERRQQRLKREQEERLEQRLKREEVERLEQEERREQRLKREEPEEE 628
Query: 307 -------TLELEVEVERLLHEQEVESRRPVVRLERPFQPAEESVTLEFAKENRKCQEQAV 359
+ E E ++ L ++ E R ++ E + E+ + E +E R EQ +
Sbjct: 629 RRQQLLKSEEQEERRQQQLRREQQERREQRLKREEEEERLEQRLKREHEEERR---EQEL 685
Query: 360 SPKVDDQ 366
+ + +Q
Sbjct: 686 AEEEQEQ 692
Score = 44.7 bits (104), Expect = 1e-04
Identities = 51/231 (22%), Positives = 110/231 (47%), Gaps = 26/231 (11%)
Query: 148 EILPPKPDCKLEKKKVELQEKSRWEVLQQEQRLM-EEKNKRKKALLAKAI---------- 196
++L +P+ K +++ E + + E+ Q+E++L+ EE+ KR++ +
Sbjct: 972 QLLGEEPE-KRRRQEREKKYREEEELQQEEEQLLREEREKRRRQEWERQYRKKDELQQEE 1030
Query: 197 -----AERSKRTQAETMKLKRIQKELQALDDMVSADIGILRNRIDQASLDYSYAR-KRFD 250
ER KR E + R ++ELQ ++ + +G R + L+ Y + +
Sbjct: 1031 EQLLREEREKRRLQERERQYREEEELQQEEEQL---LGEERETRRRQELERQYRKEEELQ 1087
Query: 251 RAEAEYIAAKLDIQRKTEIKEQLTEHLCTIIQQNELRKAKKLEELMQQLDVEADEETLEL 310
+ E + + + + +R+ E + Q E ++ +L + ++ + Q+L+ + EE E+
Sbjct: 1088 QEEEQLLREEPEKRRRQERERQCREEEELQQEEEQLLREEREKRRRQELERQYREEE-EV 1146
Query: 311 EVEVERLLHEQEVESRRPVV----RLERPFQPAEESVTLEFAKENRKCQEQ 357
+ E E+LL E+ + RR + R E Q EE + E ++ R+ +E+
Sbjct: 1147 QQEEEQLLREEPEKRRRQELERQYREEEELQQEEEQLLREEQEKRRQERER 1197
Score = 43.9 bits (102), Expect = 3e-04
Identities = 50/226 (22%), Positives = 103/226 (45%), Gaps = 20/226 (8%)
Query: 138 ENSHDGHNNVEILPPKPDCKLEKKKVELQEKSRWEVLQQEQRLMEEKNKRKKALLAKAIA 197
E S G + PP E+++ +L+ + R Q+EQR + E+ ++++ +
Sbjct: 775 EKSERGRQRLSARPPLR----EQRERQLRAEERQ---QREQRFLPEEEEKEQRRRQRRER 827
Query: 198 ERSKRTQAETMKLKRIQK--ELQALDDMVSADIGILRNRIDQASLDYSYARKRFDRAEAE 255
E+ + E +L+R ++ +LQ +D + D R++ + + + + +
Sbjct: 828 EKELQFLEEEEQLQRRERAQQLQEEEDGLQEDQERRRSQEQRRDQKWRWQLEEERKRRRH 887
Query: 256 YIAAKLDIQRKTEIKEQLTEHLCTIIQQNELRKAKKLEELMQQLDVEADEETLELEVEVE 315
+ AK +Q + ++QL + +Q+ E K ++ E+ Q + E +L+ E E
Sbjct: 888 TLYAKPALQEQLRKEQQLLQEEEEELQREEREKRRRQEQERQYREEE------QLQQEEE 941
Query: 316 RLLHEQEVESRRP----VVRLERPFQPAEESVTLEFAKENRKCQEQ 357
+LL E+ + RR R ++ Q EE + E E R+ QE+
Sbjct: 942 QLLREEREKRRRQERERQYRKDKKLQQKEEQLLGE-EPEKRRRQER 986
Score = 43.1 bits (100), Expect = 4e-04
Identities = 46/215 (21%), Positives = 98/215 (45%), Gaps = 20/215 (9%)
Query: 160 KKKVELQEKSRWEVLQQEQRLMEEKNKRKKALLAKAIAERSKRTQAETMKLKRIQKELQA 219
+++ +LQ + R + LQ+E+ ++E +R+++ + + + + E + + A
Sbjct: 835 EEEEQLQRRERAQQLQEEEDGLQEDQERRRSQEQRRDQKWRWQLEEERKRRRHTLYAKPA 894
Query: 220 LDDMVSADIGILRNRIDQASLDYSYARKRFDRAEAEYIAAKLDIQRKTEIKEQLTEHLCT 279
L + + + +L+ ++ + R+R ++ E +Y + Q + ++ + E
Sbjct: 895 LQEQLRKEQQLLQEEEEELQREEREKRRRQEQ-ERQYREEEQLQQEEEQLLREEREKRRR 953
Query: 280 IIQQNELRKAKKLEELMQQLDVEADE------------ETLELEVEVERLLHEQEVESRR 327
++ + RK KKL++ +QL E E E EL+ E E+LL E+ + RR
Sbjct: 954 QERERQYRKDKKLQQKEEQLLGEEPEKRRRQEREKKYREEEELQQEEEQLLREEREKRRR 1013
Query: 328 PVVRLERPFQ-----PAEESVTLEFAKENRKCQEQ 357
ER ++ EE L +E R+ QE+
Sbjct: 1014 Q--EWERQYRKKDELQQEEEQLLREEREKRRLQER 1046
Score = 38.9 bits (89), Expect = 0.008
Identities = 62/317 (19%), Positives = 141/317 (44%), Gaps = 53/317 (16%)
Query: 35 EEELRRLKQTKDPFEPQRRLPAKKSRQQLQREKALVEQSQKLGLQDGSTSLLPEQLLSAP 94
E+++RR +Q + E +++L ++ +QQL++E+ + + LQ+ +QL
Sbjct: 1585 EQKVRRQEQERKFMEDEQQLRRQEGQQQLRQERDRKFREDEQLLQERE----EQQLHRQE 1640
Query: 95 KQRVNVQKPPFSSPTLPSHFTLTSPVGDGQPQGIESQPKELGLENSHDG--HNNVEILPP 152
+ R +++ P + Q +E L + D ++L
Sbjct: 1641 RDRKFLEEEP----------------------QLRRQEREQQLRHDRDRKFREEEQLLQE 1678
Query: 153 KPDCKLEKKKVELQEKSRWEVLQQEQR----LMEEKNKRKKALLAKAIAERSKRTQAETM 208
+ +L +++ + + + + L++++R L EE+ R++ L K E R + E
Sbjct: 1679 GEEQQLRRQERDRKFREEEQQLRRQERERKFLQEEQQLRRQELERKFREEEQLRQETEQE 1738
Query: 209 KLKRIQKELQALDDMVSADIGILRNRIDQASLDYSYARKRFDRAEAEYIAAKLDIQRKTE 268
+L+R ++ + L++ LR ++ L ++F R E + + + Q +++
Sbjct: 1739 QLRRQERYRKILEEEQ------LRPEREEQQLRRQERDRKF-REEEQLRQEREEQQLRSQ 1791
Query: 269 IKEQLTEHLCTIIQQNELRKAKKLEELM-QQLD--VEADEETLELEVEVERLLHEQEVES 325
++ ++ +LR+ ++ ++L QQ D +EE L+LE + +RL E++ +
Sbjct: 1792 ESDR------KFREEEQLRQEREEQQLRPQQRDGKYRWEEEQLQLEEQEQRLRQERDRQ- 1844
Query: 326 RRPVVRLERPFQPAEES 342
R E F E+S
Sbjct: 1845 ----YRAEEQFATQEKS 1857
Score = 37.4 bits (85), Expect = 0.024
Identities = 64/351 (18%), Positives = 141/351 (40%), Gaps = 28/351 (7%)
Query: 36 EELRRLKQTKDPFEPQRRLPAKKSRQQLQREKALVEQSQKLGLQDGSTSLLPEQLLSAPK 95
E+ RL+Q E +R ++ Q+L+RE+ E+ Q+L + +QL +
Sbjct: 593 EQEERLEQRLKREEVERLEQEERREQRLKREEPEEERRQQLLKSEEQEERRQQQLRREQQ 652
Query: 96 QRVNVQ-KPPFSSPTLPSHFTLTSPVGDGQPQGIESQPKELGLENSHDGHNNVEILPPKP 154
+R + K L + E + +EL E ++ PK
Sbjct: 653 ERREQRLKREEEEERLEQRLK--------REHEEERREQELAEEEQEQARERIKSRIPKW 704
Query: 155 DCKLEKKKVELQEK----SRWEVLQQEQRLMEEKNKRKKALLAKAIAERSKRTQAETMKL 210
+LE + Q K R + Q+ ++ EEK +R+++ L ER+ R Q E +
Sbjct: 705 QWQLESEADARQSKVYSRPRKQEGQRRRQEQEEKRRRRESELQWQEEERAHRQQQEEEQR 764
Query: 211 KRIQKELQALDDMVSADIGILRNRIDQASLDYSYARKRFDRAEAEYIAAKLDIQRKTEIK 270
+ + QA + + + + + + E ++ + + +++ +
Sbjct: 765 RDFTWQWQAEEKSERGRQRLSARPPLREQRERQLRAEERQQREQRFLPEEEEKEQRRRQR 824
Query: 271 EQLTEHLCTIIQQNELRKAKKLEELMQQLD-VEADEE-------------TLELEVEVER 316
+ + L + ++ +L++ ++ ++L ++ D ++ D+E +LE E +R
Sbjct: 825 REREKELQFLEEEEQLQRRERAQQLQEEEDGLQEDQERRRSQEQRRDQKWRWQLEEERKR 884
Query: 317 LLHEQEVE-SRRPVVRLERPFQPAEESVTLEFAKENRKCQEQAVSPKVDDQ 366
H + + + +R E+ EE +E R+ QEQ + ++Q
Sbjct: 885 RRHTLYAKPALQEQLRKEQQLLQEEEEELQREEREKRRRQEQERQYREEEQ 935
Score = 36.2 bits (82), Expect = 0.053
Identities = 35/174 (20%), Positives = 82/174 (47%), Gaps = 9/174 (5%)
Query: 35 EEELRRLKQTKDPFEPQRRLPAKKSRQQLQREKALVEQSQK--LGLQDGSTSLLPEQLLS 92
E++LRR ++ + + +++L ++ ++ + E+ L +++++ L Q+ +L E+ L
Sbjct: 1697 EQQLRRQERERKFLQEEQQLRRQELERKFREEEQLRQETEQEQLRRQERYRKILEEEQLR 1756
Query: 93 APKQRVNVQKPPFSSPTLPSHFTLTSPVGDGQPQGIESQPKELGLENSHDGHNNVEILPP 152
++ +++ L + Q + ES K E ++ P
Sbjct: 1757 PEREEQQLRRQE-RDRKFREEEQLRQEREEQQLRSQESDRKFREEEQLRQEREEQQLRPQ 1815
Query: 153 KPDCKLEKKKVELQEKSRWEVLQQEQRLMEEKNKRKKALLAKAIAERSKRTQAE 206
+ D K ++ +LQ + +QEQRL +E++++ +A A E+S+R + E
Sbjct: 1816 QRDGKYRWEEEQLQLE------EQEQRLRQERDRQYRAEEQFATQEKSRREEQE 1863
Score = 35.4 bits (80), Expect = 0.090
Identities = 55/288 (19%), Positives = 116/288 (40%), Gaps = 27/288 (9%)
Query: 80 DGSTSLLPEQLLSAPKQRVNVQKPPFSSPTLPSHFTLTSPVGDGQPQGIESQPKEL--GL 137
DG SLL ++ ++R P L G + Q + Q +EL G
Sbjct: 104 DGKESLLQDRRQEEDQRRFE-----------PRDRQLEEEPGQRRRQKRQEQERELAEGE 152
Query: 138 ENSHDGHNNVEILPPKPDCKLEKKKVELQEKSRWEVLQQE---------QRLMEEKNKRK 188
E S + + D +L +++ E QE+ +++ + +E+ R+
Sbjct: 153 EQSEKQERLEQRDRQRRDEELWRQRQEWQEREERRAEEEQLQSCKGHETEEFPDEEQLRR 212
Query: 189 KALLAKAIAERSKRTQAETMKLKRIQKELQALDDMVSADIGILRNRIDQASLDYSYARKR 248
+ LL R ++ Q + R+ +E + + + R ++ L +++
Sbjct: 213 RELLELRRKGREEKQQQRRERQDRVFQEEEEKEWRKRETV----LRKEEEKLQEEEPQRQ 268
Query: 249 FDRAEAEYIAAKLDIQRKTEIKEQLTEHLCTIIQQNELRKAKKLEELMQQLDVEADEETL 308
+ E E KL+ Q +++ + + ++ +LR+ ++ E QQ + +E
Sbjct: 269 RELQEEEEQLRKLERQELRRERQEEEQQQQRLRREQQLRRKQEEERREQQEERREQQERR 328
Query: 309 ELEVE-VERLLHEQEVESRRPVVRLERPFQPAEESVTLEFAKENRKCQ 355
E + E E+ L ++ E R +R E+ + E+ + E +E R+ Q
Sbjct: 329 EQQEERREQQLRREQEERREQQLRREQEEERREQQLRREQEEERREQQ 376
Score = 35.0 bits (79), Expect = 0.12
Identities = 40/204 (19%), Positives = 95/204 (46%), Gaps = 20/204 (9%)
Query: 155 DCKLEKKKVELQEKSRWEVLQQEQRLMEEKNKRKKALLAKAIAERSKRTQAETMKLKRIQ 214
D K ++++ QE+ R + L++EQRL ++ +RK + + + + Q + ++ +
Sbjct: 1359 DRKFREEELRHQEQGR-KFLEEEQRLRRQERERKFLKEEQQLRCQEREQQLRQDRDRKFR 1417
Query: 215 KELQALDDMVSADIGILRNRIDQASLDYSYARKRFDRAEAEYIAAKLDIQRKTEIKEQLT 274
+E Q L R D+ + +R +R E +++ + ++++ K +
Sbjct: 1418 EEEQQLS----------RQERDRKFREEEQQVRRQER-ERKFLEEEQQLRQERHRKFREE 1466
Query: 275 EHLCTIIQQNELRKAKKLEELMQQLDVEADEETLELEVEVERLLHEQEVESRRPVVR-LE 333
E L ++ +L + ++ + ++ +E+ L + E +R EQE+ S+ P + LE
Sbjct: 1467 EQLLQEREEQQLHRQERDRKFLE------EEQQLRRQ-ERDRKFREQELRSQEPERKFLE 1519
Query: 334 RPFQPAEESVTLEFAKENRKCQEQ 357
Q + +F +E ++ + Q
Sbjct: 1520 EEQQLHRQQRQRKFLQEEQQLRRQ 1543
>gi|22035604 mitogen-activated protein kinase kinase kinase kinase 4
isoform 2 [Homo sapiens]
Length = 1320
Score = 48.1 bits (113), Expect = 1e-05
Identities = 48/237 (20%), Positives = 110/237 (46%), Gaps = 37/237 (15%)
Query: 130 SQPKELGLENSHDGHNNVEILPPKPDCKLEKKKVELQEKSRWEVLQQEQRLMEEKNKRKK 189
S+ +E + +++ +P + + + +++ + K R E L+++Q L E++ + ++
Sbjct: 326 SEEEEEEVPEQEGEPSSIVNVPGESTLRRDFLRLQQENKERSEALRRQQLLQEQQLREQE 385
Query: 190 ALLAKAIAERSKRTQAETMKLKRIQKELQALDDMVSADIGILRNRIDQASLDYSYARKRF 249
+ +AER KR + + + +R++++ + R +A ++R
Sbjct: 386 EYKRQLLAERQKRIEQQKEQRRRLEEQ---------------QRREREARRQQEREQRRR 430
Query: 250 DRAEAEYIAAKLDIQRKTEIKEQLTEHLCTIIQQNELRKAKKLEELMQQLDVEADEETLE 309
++ E + +L+ +RK E + + E E R+ ++ +E +++ + +EE
Sbjct: 431 EQEEKRRLE-ELERRRKEEEERRRAEE--------EKRRVEREQEYIRR---QLEEEQRH 478
Query: 310 LEVEVERLLHEQ---------EVESRRPVVRLERPFQPAEESVTLEFAKENRKCQEQ 357
LEV ++LL EQ E+E R RL+R Q E++ L ++R+ Q
Sbjct: 479 LEVLQQQLLQEQAMLLECRWREMEEHRQAERLQRQLQ-QEQAYLLSLQHDHRRPHPQ 534
Score = 48.1 bits (113), Expect = 1e-05
Identities = 46/190 (24%), Positives = 89/190 (46%), Gaps = 17/190 (8%)
Query: 119 PVGDGQPQGIESQPKELGLENSH---DGHNNVEILPPKPDCKLEKKKVELQEKSRWEVLQ 175
P +G+P I + P E L N + L+++++ QE+ + ++L
Sbjct: 334 PEQEGEPSSIVNVPGESTLRRDFLRLQQENKERSEALRRQQLLQEQQLREQEEYKRQLLA 393
Query: 176 QEQRLMEEKNKRKKALLAKAIAERSKRTQAETMKLKRIQKELQALDDMVSADIGILRNRI 235
+ Q+ +E++ ++++ L + ER R Q E + +R Q+E + L+++ R R
Sbjct: 394 ERQKRIEQQKEQRRRLEEQQRREREARRQQEREQRRREQEEKRRLEELE-------RRRK 446
Query: 236 DQASLDYSYARKRFDRAEAEYIAAKLDI-QRKTEIKEQ--LTEHL----CTIIQQNELRK 288
++ + KR E EYI +L+ QR E+ +Q L E C + E R+
Sbjct: 447 EEEERRRAEEEKRRVEREQEYIRRQLEEEQRHLEVLQQQLLQEQAMLLECRWREMEEHRQ 506
Query: 289 AKKLEELMQQ 298
A++L+ +QQ
Sbjct: 507 AERLQRQLQQ 516
>gi|196115290 glial fibrillary acidic protein isoform 2 [Homo
sapiens]
Length = 431
Score = 47.4 bits (111), Expect = 2e-05
Identities = 39/154 (25%), Positives = 72/154 (46%), Gaps = 11/154 (7%)
Query: 172 EVLQQEQRLMEEKNKRKKALLAKA--IAERSKRTQAETMKLKRIQKELQALDDMVSADIG 229
E E+ M E N R + + K + +++K AE +L+ KE L D+ A++
Sbjct: 64 ETRASERAEMMELNDRFASYIEKVRFLEQQNKALAAELNQLRA--KEPTKLADVYQAELR 121
Query: 230 ILRNRIDQASLDYSYARKRFDRAEAEYIAAKLDIQRKTEIKEQLTEHLCTIIQQNELRKA 289
LR R+DQ + + + D + + +Q +T ++ + +L Q+ +
Sbjct: 122 ELRLRLDQLTANSARLEVERDNLAQDLATVRQKLQDETNLRLEAENNLAAYRQEAD---- 177
Query: 290 KKLEELMQQLDVEADEETLELEVEVERLLHEQEV 323
E + +LD+E E+LE E+ R +HE+EV
Sbjct: 178 ---EATLARLDLERKIESLEEEIRFLRKIHEEEV 208
Score = 31.2 bits (69), Expect = 1.7
Identities = 44/179 (24%), Positives = 85/179 (47%), Gaps = 21/179 (11%)
Query: 161 KKVELQE-KSRWEVLQQEQRLMEEKNKRKKA----LLAKAIAERSKRTQAETMKLKRIQK 215
++ E+ E R+ ++ R +E++NK A L AK + + QAE +L+
Sbjct: 69 ERAEMMELNDRFASYIEKVRFLEQQNKALAAELNQLRAKEPTKLADVYQAELRELRLRLD 128
Query: 216 ELQALD-------DMVSADIGILRNRI-DQASL----DYSYARKRFDRAEAEYIAAKLDI 263
+L A D ++ D+ +R ++ D+ +L + + A R + EA A+LD+
Sbjct: 129 QLTANSARLEVERDNLAQDLATVRQKLQDETNLRLEAENNLAAYRQEADEATL--ARLDL 186
Query: 264 QRKTEIKEQLTEHLCTIIQQNELRKAKKLEELMQQLDVEADEETLELEVEVERLLHEQE 322
+RK E E+ L I + E+R+ ++ + QQ+ VE D +L ++ + + E
Sbjct: 187 ERKIESLEEEIRFL-RKIHEEEVRELQE-QLARQQVHVELDVAKPDLTAALKEIRTQYE 243
>gi|4503979 glial fibrillary acidic protein isoform 1 [Homo sapiens]
Length = 432
Score = 47.4 bits (111), Expect = 2e-05
Identities = 39/154 (25%), Positives = 72/154 (46%), Gaps = 11/154 (7%)
Query: 172 EVLQQEQRLMEEKNKRKKALLAKA--IAERSKRTQAETMKLKRIQKELQALDDMVSADIG 229
E E+ M E N R + + K + +++K AE +L+ KE L D+ A++
Sbjct: 64 ETRASERAEMMELNDRFASYIEKVRFLEQQNKALAAELNQLRA--KEPTKLADVYQAELR 121
Query: 230 ILRNRIDQASLDYSYARKRFDRAEAEYIAAKLDIQRKTEIKEQLTEHLCTIIQQNELRKA 289
LR R+DQ + + + D + + +Q +T ++ + +L Q+ +
Sbjct: 122 ELRLRLDQLTANSARLEVERDNLAQDLATVRQKLQDETNLRLEAENNLAAYRQEAD---- 177
Query: 290 KKLEELMQQLDVEADEETLELEVEVERLLHEQEV 323
E + +LD+E E+LE E+ R +HE+EV
Sbjct: 178 ---EATLARLDLERKIESLEEEIRFLRKIHEEEV 208
Score = 31.2 bits (69), Expect = 1.7
Identities = 44/179 (24%), Positives = 85/179 (47%), Gaps = 21/179 (11%)
Query: 161 KKVELQE-KSRWEVLQQEQRLMEEKNKRKKA----LLAKAIAERSKRTQAETMKLKRIQK 215
++ E+ E R+ ++ R +E++NK A L AK + + QAE +L+
Sbjct: 69 ERAEMMELNDRFASYIEKVRFLEQQNKALAAELNQLRAKEPTKLADVYQAELRELRLRLD 128
Query: 216 ELQALD-------DMVSADIGILRNRI-DQASL----DYSYARKRFDRAEAEYIAAKLDI 263
+L A D ++ D+ +R ++ D+ +L + + A R + EA A+LD+
Sbjct: 129 QLTANSARLEVERDNLAQDLATVRQKLQDETNLRLEAENNLAAYRQEADEATL--ARLDL 186
Query: 264 QRKTEIKEQLTEHLCTIIQQNELRKAKKLEELMQQLDVEADEETLELEVEVERLLHEQE 322
+RK E E+ L I + E+R+ ++ + QQ+ VE D +L ++ + + E
Sbjct: 187 ERKIESLEEEIRFL-RKIHEEEVRELQE-QLARQQVHVELDVAKPDLTAALKEIRTQYE 243
>gi|217272804 hyaluronan-mediated motility receptor isoform d [Homo
sapiens]
Length = 638
Score = 47.4 bits (111), Expect = 2e-05
Identities = 53/202 (26%), Positives = 97/202 (48%), Gaps = 43/202 (21%)
Query: 161 KKVELQEKSRWEVLQQEQRLMEEKNKRKKALLAKAIAERSKRTQAETMKLKRIQKELQAL 220
K++E + KSR E E +L+EEK K K+A L K+ A TQA + ++ +Q+L
Sbjct: 314 KQLEEEAKSRAE----ELKLLEEKLKGKEAELEKSSAAH---TQATLLLQEKYDSMVQSL 366
Query: 221 DDMVS---ADIGILRNRIDQASLDYSYARKRFDRA-----------------EAEYIAAK 260
+D+ + + + + I+ L+ S +++ +A EY+
Sbjct: 367 EDVTAQFESYKALTASEIEDLKLENSSLQEKAAKAGKNAEDVQHQILATESSNQEYVRML 426
Query: 261 LDIQRKTEIKE-QLTEHLCTIIQ-----QNELRKAKKLEELMQQLD------VEADEETL 308
LD+Q K+ +KE ++ E + +Q QN+L++ + E+ +QL+ E + T
Sbjct: 427 LDLQTKSALKETEIKEITVSFLQKITDLQNQLKQQE--EDFRKQLEDEEGRKAEKENTTA 484
Query: 309 ELEVEVE--RLLHEQEVESRRP 328
EL E+ RLL+E+ +P
Sbjct: 485 ELTEEINKWRLLYEELYNKTKP 506
Score = 40.4 bits (93), Expect = 0.003
Identities = 47/175 (26%), Positives = 89/175 (50%), Gaps = 16/175 (9%)
Query: 167 EKSRWEVLQQEQRLMEEKNK--RKKALLAKAIAERSKRTQAETMKLKRIQKELQALDDMV 224
EK + ++ Q E+ L E+ ++ K L + I SK+ + +K + ++KE + D V
Sbjct: 162 EKYKLDIAQLEENLKEKNDEILSLKQSLEENIVILSKQVEDLNVKCQLLEKEKE---DHV 218
Query: 225 SADIGILRN-RIDQASLDYSYARKRFDRAEAEYIAAKLD--IQRKTEIKEQLTEHLCTII 281
+ + N + +L + ++ +R + + ++D +Q++ E+ L + LC+
Sbjct: 219 NRNREHNENLNAEMQNLKQKFILEQQEREKLQQKELQIDSLLQQEKELSSSLHQKLCSF- 277
Query: 282 QQNELRKAKKL--EELMQQLDVEADEETLELEVEVERLLH--EQEVESRRPVVRL 332
Q E+ K K L EEL Q LD E D + + E + ERL+ E+E +SR ++L
Sbjct: 278 -QEEMVKEKNLFEEELKQTLD-ELD-KLQQKEEQAERLVKQLEEEAKSRAEELKL 329
>gi|217272802 hyaluronan-mediated motility receptor isoform a [Homo
sapiens]
Length = 725
Score = 47.4 bits (111), Expect = 2e-05
Identities = 53/202 (26%), Positives = 97/202 (48%), Gaps = 43/202 (21%)
Query: 161 KKVELQEKSRWEVLQQEQRLMEEKNKRKKALLAKAIAERSKRTQAETMKLKRIQKELQAL 220
K++E + KSR E E +L+EEK K K+A L K+ A TQA + ++ +Q+L
Sbjct: 401 KQLEEEAKSRAE----ELKLLEEKLKGKEAELEKSSAAH---TQATLLLQEKYDSMVQSL 453
Query: 221 DDMVS---ADIGILRNRIDQASLDYSYARKRFDRA-----------------EAEYIAAK 260
+D+ + + + + I+ L+ S +++ +A EY+
Sbjct: 454 EDVTAQFESYKALTASEIEDLKLENSSLQEKAAKAGKNAEDVQHQILATESSNQEYVRML 513
Query: 261 LDIQRKTEIKE-QLTEHLCTIIQ-----QNELRKAKKLEELMQQLD------VEADEETL 308
LD+Q K+ +KE ++ E + +Q QN+L++ + E+ +QL+ E + T
Sbjct: 514 LDLQTKSALKETEIKEITVSFLQKITDLQNQLKQQE--EDFRKQLEDEEGRKAEKENTTA 571
Query: 309 ELEVEVE--RLLHEQEVESRRP 328
EL E+ RLL+E+ +P
Sbjct: 572 ELTEEINKWRLLYEELYNKTKP 593
Score = 40.4 bits (93), Expect = 0.003
Identities = 47/175 (26%), Positives = 89/175 (50%), Gaps = 16/175 (9%)
Query: 167 EKSRWEVLQQEQRLMEEKNK--RKKALLAKAIAERSKRTQAETMKLKRIQKELQALDDMV 224
EK + ++ Q E+ L E+ ++ K L + I SK+ + +K + ++KE + D V
Sbjct: 249 EKYKLDIAQLEENLKEKNDEILSLKQSLEENIVILSKQVEDLNVKCQLLEKEKE---DHV 305
Query: 225 SADIGILRN-RIDQASLDYSYARKRFDRAEAEYIAAKLD--IQRKTEIKEQLTEHLCTII 281
+ + N + +L + ++ +R + + ++D +Q++ E+ L + LC+
Sbjct: 306 NRNREHNENLNAEMQNLKQKFILEQQEREKLQQKELQIDSLLQQEKELSSSLHQKLCSF- 364
Query: 282 QQNELRKAKKL--EELMQQLDVEADEETLELEVEVERLLH--EQEVESRRPVVRL 332
Q E+ K K L EEL Q LD E D + + E + ERL+ E+E +SR ++L
Sbjct: 365 -QEEMVKEKNLFEEELKQTLD-ELD-KLQQKEEQAERLVKQLEEEAKSRAEELKL 416
Score = 29.6 bits (65), Expect = 4.9
Identities = 35/199 (17%), Positives = 87/199 (43%), Gaps = 18/199 (9%)
Query: 172 EVLQQEQRLMEEKNKRKKALLAKAIAERSKRTQAETMKLKRIQKELQALDDMVSADIGIL 231
+V E + +KN + +L K I + A+ +++ ++ EL+ ++ ++A L
Sbjct: 68 KVKSSESKKESQKNDKDLKILEKEIRVLLQERGAQDRRIQDLETELEKMEARLNA---AL 124
Query: 232 RNRIDQASLDYSYARKRFDRAEAEYIAAKLDIQRKTEIKEQLTEHLCTIIQQNELRKAKK 291
R + ++ + + ++ + + K++ E + I+ ++ K
Sbjct: 125 REKTSLSANNATLEKQLIELTRTNELL-------KSKFSENGNQKNLRILSLELMKLRNK 177
Query: 292 LEELMQQLDVEADEETLELEVEV-ERLLHEQ-----EVESRRPVVRLERPFQPAEESVTL 345
E M+ + A +E +E++++V +R L E ++E + + E+ + +E L
Sbjct: 178 RETKMR--GMMAKQEGMEMKLQVTQRSLEESQGKIAQLEGKLVSIEKEKIDEKSETEKLL 235
Query: 346 EFAKENRKCQEQAVSPKVD 364
E+ +E +Q K+D
Sbjct: 236 EYIEEISCASDQVEKYKLD 254
>gi|217416398 hyaluronan-mediated motility receptor isoform c [Homo
sapiens]
Length = 709
Score = 47.4 bits (111), Expect = 2e-05
Identities = 53/202 (26%), Positives = 97/202 (48%), Gaps = 43/202 (21%)
Query: 161 KKVELQEKSRWEVLQQEQRLMEEKNKRKKALLAKAIAERSKRTQAETMKLKRIQKELQAL 220
K++E + KSR E E +L+EEK K K+A L K+ A TQA + ++ +Q+L
Sbjct: 385 KQLEEEAKSRAE----ELKLLEEKLKGKEAELEKSSAAH---TQATLLLQEKYDSMVQSL 437
Query: 221 DDMVS---ADIGILRNRIDQASLDYSYARKRFDRA-----------------EAEYIAAK 260
+D+ + + + + I+ L+ S +++ +A EY+
Sbjct: 438 EDVTAQFESYKALTASEIEDLKLENSSLQEKAAKAGKNAEDVQHQILATESSNQEYVRML 497
Query: 261 LDIQRKTEIKE-QLTEHLCTIIQ-----QNELRKAKKLEELMQQLD------VEADEETL 308
LD+Q K+ +KE ++ E + +Q QN+L++ + E+ +QL+ E + T
Sbjct: 498 LDLQTKSALKETEIKEITVSFLQKITDLQNQLKQQE--EDFRKQLEDEEGRKAEKENTTA 555
Query: 309 ELEVEVE--RLLHEQEVESRRP 328
EL E+ RLL+E+ +P
Sbjct: 556 ELTEEINKWRLLYEELYNKTKP 577
Score = 40.4 bits (93), Expect = 0.003
Identities = 47/175 (26%), Positives = 89/175 (50%), Gaps = 16/175 (9%)
Query: 167 EKSRWEVLQQEQRLMEEKNK--RKKALLAKAIAERSKRTQAETMKLKRIQKELQALDDMV 224
EK + ++ Q E+ L E+ ++ K L + I SK+ + +K + ++KE + D V
Sbjct: 233 EKYKLDIAQLEENLKEKNDEILSLKQSLEENIVILSKQVEDLNVKCQLLEKEKE---DHV 289
Query: 225 SADIGILRN-RIDQASLDYSYARKRFDRAEAEYIAAKLD--IQRKTEIKEQLTEHLCTII 281
+ + N + +L + ++ +R + + ++D +Q++ E+ L + LC+
Sbjct: 290 NRNREHNENLNAEMQNLKQKFILEQQEREKLQQKELQIDSLLQQEKELSSSLHQKLCSF- 348
Query: 282 QQNELRKAKKL--EELMQQLDVEADEETLELEVEVERLLH--EQEVESRRPVVRL 332
Q E+ K K L EEL Q LD E D + + E + ERL+ E+E +SR ++L
Sbjct: 349 -QEEMVKEKNLFEEELKQTLD-ELD-KLQQKEEQAERLVKQLEEEAKSRAEELKL 400
>gi|217416394 hyaluronan-mediated motility receptor isoform b [Homo
sapiens]
Length = 724
Score = 47.4 bits (111), Expect = 2e-05
Identities = 53/202 (26%), Positives = 97/202 (48%), Gaps = 43/202 (21%)
Query: 161 KKVELQEKSRWEVLQQEQRLMEEKNKRKKALLAKAIAERSKRTQAETMKLKRIQKELQAL 220
K++E + KSR E E +L+EEK K K+A L K+ A TQA + ++ +Q+L
Sbjct: 400 KQLEEEAKSRAE----ELKLLEEKLKGKEAELEKSSAAH---TQATLLLQEKYDSMVQSL 452
Query: 221 DDMVS---ADIGILRNRIDQASLDYSYARKRFDRA-----------------EAEYIAAK 260
+D+ + + + + I+ L+ S +++ +A EY+
Sbjct: 453 EDVTAQFESYKALTASEIEDLKLENSSLQEKAAKAGKNAEDVQHQILATESSNQEYVRML 512
Query: 261 LDIQRKTEIKE-QLTEHLCTIIQ-----QNELRKAKKLEELMQQLD------VEADEETL 308
LD+Q K+ +KE ++ E + +Q QN+L++ + E+ +QL+ E + T
Sbjct: 513 LDLQTKSALKETEIKEITVSFLQKITDLQNQLKQQE--EDFRKQLEDEEGRKAEKENTTA 570
Query: 309 ELEVEVE--RLLHEQEVESRRP 328
EL E+ RLL+E+ +P
Sbjct: 571 ELTEEINKWRLLYEELYNKTKP 592
Score = 40.4 bits (93), Expect = 0.003
Identities = 47/175 (26%), Positives = 89/175 (50%), Gaps = 16/175 (9%)
Query: 167 EKSRWEVLQQEQRLMEEKNK--RKKALLAKAIAERSKRTQAETMKLKRIQKELQALDDMV 224
EK + ++ Q E+ L E+ ++ K L + I SK+ + +K + ++KE + D V
Sbjct: 248 EKYKLDIAQLEENLKEKNDEILSLKQSLEENIVILSKQVEDLNVKCQLLEKEKE---DHV 304
Query: 225 SADIGILRN-RIDQASLDYSYARKRFDRAEAEYIAAKLD--IQRKTEIKEQLTEHLCTII 281
+ + N + +L + ++ +R + + ++D +Q++ E+ L + LC+
Sbjct: 305 NRNREHNENLNAEMQNLKQKFILEQQEREKLQQKELQIDSLLQQEKELSSSLHQKLCSF- 363
Query: 282 QQNELRKAKKL--EELMQQLDVEADEETLELEVEVERLLH--EQEVESRRPVVRL 332
Q E+ K K L EEL Q LD E D + + E + ERL+ E+E +SR ++L
Sbjct: 364 -QEEMVKEKNLFEEELKQTLD-ELD-KLQQKEEQAERLVKQLEEEAKSRAEELKL 415
>gi|31982906 cingulin-like 1 [Homo sapiens]
Length = 1302
Score = 47.0 bits (110), Expect = 3e-05
Identities = 43/227 (18%), Positives = 111/227 (48%), Gaps = 29/227 (12%)
Query: 157 KLEKKKVELQEKSRWEVLQQEQRLME--EKNKRKKALLAKAIAERSKRTQAETMKLKRIQ 214
KL+K+ ++ E SR L+ + +L E EKN+R+ A + + + E++ + + ++Q
Sbjct: 952 KLQKEMADIVEASRTSTLELQNQLDEYKEKNRRELAEMQRQLKEKTLEAEKSRLTAMKMQ 1011
Query: 215 KELQALDDMV-----SADIGIL-RNRIDQASLDYSY-----ARKRFDRA------EAEYI 257
E++ +++ + + D + R ++Q D Y + + DR+ E +
Sbjct: 1012 DEMRLMEEELRDYQRAQDEALTKRQLLEQTLKDLEYELEAKSHLKDDRSRLVKQMEDKVS 1071
Query: 258 AAKLDIQRKTEIKEQLTEHLCTIIQQNELRKAKKLEELMQQLDVEADEETLELEVEVERL 317
+++++ + + L+E + +Q E + + L+E + D+E D+ +LE +
Sbjct: 1072 QLEMELEEERNNSDLLSERISRSREQMEQLRNELLQERAARQDLECDKISLERQ------ 1125
Query: 318 LHEQEVESRRPVVRLERPFQPAEESVTLEFAKENRKCQEQAVSPKVD 364
++++SR ++ LE ++ ++E + ++ + +++ S + D
Sbjct: 1126 --NKDLKSR--IIHLEGSYRSSKEGLVVQMEARIAELEDRLESEERD 1168
>gi|32698688 citron [Homo sapiens]
Length = 2027
Score = 46.6 bits (109), Expect = 4e-05
Identities = 49/208 (23%), Positives = 96/208 (46%), Gaps = 18/208 (8%)
Query: 159 EKKKVELQEKSRWEVLQQEQRLMEEKNKRKKALLAKAIAERSKRTQAETMKLKRIQKELQ 218
++ K E+ E ++ E + EQ+L ++ + K KA E ++ Q +R ++EL+
Sbjct: 615 DQGKPEVGEYAKLEKINAEQQLKIQELQEKLEKAVKASTEATELLQNIRQAKERAERELE 674
Query: 219 ALDDMVSADIGILRNRIDQASLDYSYARKRFDRAEAEYIAAKLDIQRKTEIKEQLTEHLC 278
L + + GI + ++ L+ + EA+ A L++ K KEQ E
Sbjct: 675 KLQNREDSSEGIRKKLVEAEELEEKH-------REAQVSAQHLEVHLKQ--KEQHYEEKI 725
Query: 279 TIIQ---QNELRKAKKLEELMQQLDVEADEETLELEVEVERLLHEQEVESR---RPVVRL 332
++ + +L + LE +MQ+ + EA E+ L E + +++ + + R + +V L
Sbjct: 726 KVLDNQIKKDLADKETLENMMQRHEEEAHEKGKILS-EQKAMINAMDSKIRSLEQRIVEL 784
Query: 333 ERPFQPAEESVTLEFAKENRKCQEQAVS 360
+ A S F + N K QE+ +S
Sbjct: 785 SEANKLAANSSL--FTQRNMKAQEEMIS 810
>gi|41322923 plectin 1 isoform 11 [Homo sapiens]
Length = 4547
Score = 46.6 bits (109), Expect = 4e-05
Identities = 82/339 (24%), Positives = 134/339 (39%), Gaps = 71/339 (20%)
Query: 34 SEEELRRLKQTKDP-FEPQRRLPAKKSRQQLQREKALVEQSQKLGLQDGSTSLLPEQL-- 90
+E+ R KQ D E ++ + RQ+ Q E+ L +L D +LL E+L
Sbjct: 2152 AEQAALRQKQAADAEMEKHKKFAEQTLRQKAQVEQELTTLRLQLEETDHQKNLLDEELQR 2211
Query: 91 -----LSAPKQRVNVQKPPFSSPTLPSHFTLTSPVGDGQPQGIESQPKELG-LENSHDGH 144
A +QR V++ FS + Q +EL L+ +
Sbjct: 2212 LKAEATEAARQRSQVEEELFS---------------------VRVQMEELSKLKARIEAE 2250
Query: 145 NNVEILPPKPDC------KLEKKKVELQEKSRWEVLQQE----QRLMEEKNKRKKALLAK 194
N IL K + + EK K +E +R V QE ++L EE +++AL K
Sbjct: 2251 NRALILRDKDNTQRFLQEEAEKMKQVAEEAARLSVAAQEAARLRQLAEEDLAQQRALAEK 2310
Query: 195 AIAERSKRTQAETMKLKRIQKELQALDDMVSADIGILRNRIDQASLDYSYARKRFDR--- 251
+ E+ + Q E +LK + LQ ++ L+ +Q + + + F R
Sbjct: 2311 MLKEKMQAVQ-EATRLKAEAELLQQQKELAQEQARRLQEDKEQMAQQLAEETQGFQRTLE 2369
Query: 252 ----------AEAEYI------------AAKLDIQRKTEIKEQLTE--HLCTIIQQNELR 287
AEAE + A+ D QR + E++ E H + Q ++
Sbjct: 2370 AERQRQLEMSAEAERLKLRVAEMSRAQARAEEDAQRFRKQAEEIGEKLHRTELATQEKVT 2429
Query: 288 KAKKLEELMQQLDVEAD---EETLELEVEVERLLHEQEV 323
+ LE QQ D +A+ E ELE E E+L E ++
Sbjct: 2430 LVQTLEIQRQQSDHDAERLREAIAELEREKEKLQQEAKL 2468
Score = 41.6 bits (96), Expect = 0.001
Identities = 45/210 (21%), Positives = 91/210 (43%), Gaps = 24/210 (11%)
Query: 160 KKKVELQEKSR-WEVLQQEQRLMEEKNKRKKALLAKAIAERSKRTQAETMKLKRIQKELQ 218
+K+++ +EK+ + V Q+EQ L + + + L + R AE + R+Q E +
Sbjct: 2044 QKRLQAEEKAHAFAVQQKEQELQQTLQQEQSVLDQLRGEAEAARRAAEEAEEARVQAERE 2103
Query: 219 ALDDMVSADIGILRNRIDQAS-LDYSYARKRFDRAEAEYIAAKLDIQRKTEIKEQLTEHL 277
A R ++++A L S + RA+A+ A KL + + E +
Sbjct: 2104 AAQS---------RRQVEEAERLKQSAEEQAQARAQAQAAAEKLRKEAEQEAARRAQAEQ 2154
Query: 278 CTIIQQN----ELRKAKKLEELMQQLDVEADEETLELEVEVERLLHEQEVESRRPVVRLE 333
+ Q+ E+ K KK E + + ++E L +++E H++ + L+
Sbjct: 2155 AALRQKQAADAEMEKHKKFAEQTLRQKAQVEQELTTLRLQLEETDHQKNL--------LD 2206
Query: 334 RPFQPAEESVTLEFAKENRKCQEQAVSPKV 363
Q + T E A++ + +E+ S +V
Sbjct: 2207 EELQRLKAEAT-EAARQRSQVEEELFSVRV 2235
Score = 41.2 bits (95), Expect = 0.002
Identities = 42/208 (20%), Positives = 83/208 (39%), Gaps = 8/208 (3%)
Query: 159 EKKKVELQEKSRWEVLQQEQRLMEEKNKRKKALLAKAIAERSKRTQAETMKLKRIQKELQ 218
+ + E+Q K+R + RL E+ R L +A + + E L+ +E +
Sbjct: 1427 QSSEAEIQAKARQAEAAERSRLRIEEEIRVVRLQLEATERQRGGAEGELQALRARAEEAE 1486
Query: 219 ALDDMVSADIGILRNRIDQASLDYSYARKRFDRAEAEYIAAKLDIQRKTEIKEQLTEHLC 278
A + LR ++ D S +++ + A + A+ + R+ + Q E L
Sbjct: 1487 AQKRQAQEEAERLRRQVQ----DESQRKRQAEVELASRVKAEAEAAREKQRALQALEEL- 1541
Query: 279 TIIQQNELRKAKKLEELMQQLDVEADEETLELEVEVERLLHEQEVESRRPVVRLERPFQP 338
+Q E + + E+ + V+ ET + E E L + +LER Q
Sbjct: 1542 -RLQAEEAERRLRQAEVERARQVQVALETAQRSAEAE--LQSKRASFAEKTAQLERSLQE 1598
Query: 339 AEESVTLEFAKENRKCQEQAVSPKVDDQ 366
+V + R+ Q+QA + + ++
Sbjct: 1599 EHVAVAQLREEAERRAQQQAEAERAREE 1626
Score = 37.7 bits (86), Expect = 0.018
Identities = 99/419 (23%), Positives = 156/419 (37%), Gaps = 82/419 (19%)
Query: 21 RWPGPMAQGWAGFSEEE-----LRRLKQTKDPF-----------EPQRRLPAKKS---RQ 61
RW +AQ E E LR +++ DP E + +P S R+
Sbjct: 1187 RWQAVLAQTDVRQRELEQLGRQLRYYRESADPLGAWLQDARRRQEQIQAMPLADSQAVRE 1246
Query: 62 QLQREKALVEQSQKLGLQDGSTSLLPEQLLSAPKQ------RVNVQKPPFSSPTLPSHFT 115
QL++E+AL+E+ ++ G + +Q ++A K Q P +SP
Sbjct: 1247 QLRQEQALLEEIERHGEKVEECQRFAKQYINAIKDYELQLVTYKAQLEPVASPAKKPKVQ 1306
Query: 116 LTSPVGDGQPQGIESQPKELGLENSHDGHNNVEILPPKPDCKLEKKKVELQEKSRWEVLQ 175
S + + + EL S E L + E++ E Q E L
Sbjct: 1307 SGSESVIQEYVDLRTHYSELTTLTSQYIKFISETLRRMEE---EERLAEQQRAEERERLA 1363
Query: 176 QEQRLMEEKNKRKKA-LLAKAIAER-----SKRTQAETMK-----------LKRIQKELQ 218
+ + +E++ + +A AKA AER +R Q E ++ + IQ+ELQ
Sbjct: 1364 EVEAALEKQRQLAEAHAQAKAQAEREAKELQQRMQEEVVRREEAAVDAQQQKRSIQEELQ 1423
Query: 219 ALDDMVSADIGILRNRIDQAS--------------LDYSYARKRFDRAEAEYIAAKLDIQ 264
L A+I + + A L ++ AE E A + +
Sbjct: 1424 QLRQSSEAEIQAKARQAEAAERSRLRIEEEIRVVRLQLEATERQRGGAEGELQALRARAE 1483
Query: 265 RKTEIKEQL---TEHLCTIIQQNELRKAKKLEELMQQLDVEADE-----------ETLEL 310
K Q E L +Q RK + EL ++ EA+ E L L
Sbjct: 1484 EAEAQKRQAQEEAERLRRQVQDESQRKRQAEVELASRVKAEAEAAREKQRALQALEELRL 1543
Query: 311 EV-EVERLLHEQEVESRRPV-VRLERPFQPAE---ESVTLEFAKE----NRKCQEQAVS 360
+ E ER L + EVE R V V LE + AE +S FA++ R QE+ V+
Sbjct: 1544 QAEEAERRLRQAEVERARQVQVALETAQRSAEAELQSKRASFAEKTAQLERSLQEEHVA 1602
Score = 36.6 bits (83), Expect = 0.040
Identities = 73/357 (20%), Positives = 139/357 (38%), Gaps = 59/357 (16%)
Query: 26 MAQGWAGFSEEELRRLKQTKDPFEPQRRLPAKKSRQQLQREKALVEQSQKLGLQDGSTSL 85
+AQ A +EE R + + E Q + + Q+L++++ L E +
Sbjct: 1657 LAQAEAEKQKEEAEREARRRGKAEEQAVRQRELAEQELEKQRQLAEGT------------ 1704
Query: 86 LPEQLLSAPKQRVNVQKPPFSSPTLPSHFTLTSPVGDGQPQGIESQPKELGLENSHDGHN 145
+Q L+A ++ + ++ + G+ Q Q +E + L E +
Sbjct: 1705 -AQQRLAAEQELIRLR--------------AETEQGEQQRQLLEEELARLQREAAAATQK 1749
Query: 146 NVEILPPKPDCKLEKK-----KVELQEKSRWEVLQQEQRLMEEKNK----RKKALLAKAI 196
E+ + E + K +E+SR + +QRL E + ++A +A+
Sbjct: 1750 RQELEAELAKVRAEMEVLLASKARAEEESRSTSEKSKQRLEAEAGRFRELAEEAARLRAL 1809
Query: 197 AERSK-------------RTQAETMKLKRIQKELQALDDMVSADIGILRNRIDQASLDYS 243
AE +K R +AE + +++ +A A+I + + L
Sbjct: 1810 AEEAKRQRQLAEEDAARQRAEAERVLAEKLAAIGEATRLKTEAEIALKEKEAENERLRRL 1869
Query: 244 YARKRFDRAEAEYIAAKLDIQRKTEIKEQLTEHLCTIIQQNELRKAKKLEELMQQLDVEA 303
+ F R E AA Q K +I+E+L + +EL + K L E + +
Sbjct: 1870 AEDEAFQRRRLEEQAA----QHKADIEERLAQ--LRKASDSELERQKGLVEDTLRQRRQV 1923
Query: 304 DEETLELEVEVERLL---HEQEVESRRPVVRLERPFQPAEESVTLEFAKENRKCQEQ 357
+EE L L+ E+ E E+E R E + ++E LE A++ + E+
Sbjct: 1924 EEEILALKASFEKAAAGKAELELELGRIRSNAEDTLR-SKEQAELEAARQRQLAAEE 1979
Score = 36.2 bits (82), Expect = 0.053
Identities = 46/220 (20%), Positives = 97/220 (44%), Gaps = 26/220 (11%)
Query: 159 EKKKVELQEKSRWEVLQQE--QRLMEEKNKRKKALLAKAIAERSKRTQAETMKLKRIQKE 216
E+ K+ + E SR + +E QR ++ + + L +A + K T +T++++R Q +
Sbjct: 2383 ERLKLRVAEMSRAQARAEEDAQRFRKQAEEIGEKLHRTELATQEKVTLVQTLEIQRQQSD 2442
Query: 217 LQALDDMVSADIGILRNRIDQASLDYSYARKRFDRAEAEYIAAKLDIQRKTEIKEQLTEH 276
A + + I L ++ + + + + E + + + +Q +++
Sbjct: 2443 HDA--ERLREAIAELEREKEKLQQEAKLLQLKSE--EMQTVQQEQLLQETQALQQSFLSE 2498
Query: 277 LCTIIQQNEL--RKAKKLEELMQ-------QLDVEADEETLELEVEVERLL--------- 318
+++Q+ ++ KLE+L Q QL E + ++E E +RL+
Sbjct: 2499 KDSLLQRERFIEQEKAKLEQLFQDEVAKAQQLREEQQRQQQQMEQERQRLVASMEEARRR 2558
Query: 319 -HEQEVESRRPVVRLERPFQPAEESVTLEFAKENRKCQEQ 357
HE E RR L++ Q + L A+EN++ +EQ
Sbjct: 2559 QHEAEEGVRRKQEELQQLEQQRRQQEEL-LAEENQRLREQ 2597
Score = 30.0 bits (66), Expect = 3.8
Identities = 17/69 (24%), Positives = 41/69 (59%), Gaps = 5/69 (7%)
Query: 158 LEKKKVELQEKSRWEV-----LQQEQRLMEEKNKRKKALLAKAIAERSKRTQAETMKLKR 212
+E++K +L++ + EV L++EQ+ +++ ++++ L ++ E +R ++R
Sbjct: 2509 IEQEKAKLEQLFQDEVAKAQQLREEQQRQQQQMEQERQRLVASMEEARRRQHEAEEGVRR 2568
Query: 213 IQKELQALD 221
Q+ELQ L+
Sbjct: 2569 KQEELQQLE 2577
Score = 29.6 bits (65), Expect = 4.9
Identities = 60/298 (20%), Positives = 118/298 (39%), Gaps = 23/298 (7%)
Query: 34 SEEELRRLKQTKDPFEPQRRLPAKKSRQQL----QREKALVEQSQKLGLQDGSTSLLPEQ 89
++E+ RRL++ K+ Q + ++ L QR+ + ++++L L+ S +
Sbjct: 2339 AQEQARRLQEDKEQMAQQLAEETQGFQRTLEAERQRQLEMSAEAERLKLRVAEMSRAQAR 2398
Query: 90 LLSAPKQRVNVQKPPFSSPTLPSHFTLTSPVGDGQPQGIESQPKELGLENSHDGHNNVEI 149
QR Q + V Q I+ Q + E + +E
Sbjct: 2399 A-EEDAQRFRKQAEEIGEKLHRTELATQEKVTLVQTLEIQRQQSDHDAERLREAIAELER 2457
Query: 150 LPPKPDCK---LEKKKVELQEKSRWEVLQQEQRLMEEKNKRKKALLAK------AIAERS 200
K + L+ K E+Q + ++LQ+ Q L + K +LL + A+
Sbjct: 2458 EKEKLQQEAKLLQLKSEEMQTVQQEQLLQETQALQQSFLSEKDSLLQRERFIEQEKAKLE 2517
Query: 201 KRTQAETMKLKRIQKELQALDDMVSADIGILRNRIDQASLDYSYARKRFDRAEAEYIAAK 260
+ Q E K +++++E Q + + R R+ AS++ AR+R AE +
Sbjct: 2518 QLFQDEVAKAQQLREEQQRQQQQMEQE----RQRL-VASME--EARRRQHEAEEGVRRKQ 2570
Query: 261 LDIQRKTEIKEQLTEHLCTIIQQNELRKAKKLEELMQQLDVEADEETLELEVEVERLL 318
++Q+ + + Q E L + LR+ +L E + + EE +V + L
Sbjct: 2571 EELQQLEQQRRQQEELLAE--ENQRLREQLQLLEEQHRAALAHSEEVTASQVAATKTL 2626
>gi|41322914 plectin 1 isoform 10 [Homo sapiens]
Length = 4551
Score = 46.6 bits (109), Expect = 4e-05
Identities = 82/339 (24%), Positives = 134/339 (39%), Gaps = 71/339 (20%)
Query: 34 SEEELRRLKQTKDP-FEPQRRLPAKKSRQQLQREKALVEQSQKLGLQDGSTSLLPEQL-- 90
+E+ R KQ D E ++ + RQ+ Q E+ L +L D +LL E+L
Sbjct: 2156 AEQAALRQKQAADAEMEKHKKFAEQTLRQKAQVEQELTTLRLQLEETDHQKNLLDEELQR 2215
Query: 91 -----LSAPKQRVNVQKPPFSSPTLPSHFTLTSPVGDGQPQGIESQPKELG-LENSHDGH 144
A +QR V++ FS + Q +EL L+ +
Sbjct: 2216 LKAEATEAARQRSQVEEELFS---------------------VRVQMEELSKLKARIEAE 2254
Query: 145 NNVEILPPKPDC------KLEKKKVELQEKSRWEVLQQE----QRLMEEKNKRKKALLAK 194
N IL K + + EK K +E +R V QE ++L EE +++AL K
Sbjct: 2255 NRALILRDKDNTQRFLQEEAEKMKQVAEEAARLSVAAQEAARLRQLAEEDLAQQRALAEK 2314
Query: 195 AIAERSKRTQAETMKLKRIQKELQALDDMVSADIGILRNRIDQASLDYSYARKRFDR--- 251
+ E+ + Q E +LK + LQ ++ L+ +Q + + + F R
Sbjct: 2315 MLKEKMQAVQ-EATRLKAEAELLQQQKELAQEQARRLQEDKEQMAQQLAEETQGFQRTLE 2373
Query: 252 ----------AEAEYI------------AAKLDIQRKTEIKEQLTE--HLCTIIQQNELR 287
AEAE + A+ D QR + E++ E H + Q ++
Sbjct: 2374 AERQRQLEMSAEAERLKLRVAEMSRAQARAEEDAQRFRKQAEEIGEKLHRTELATQEKVT 2433
Query: 288 KAKKLEELMQQLDVEAD---EETLELEVEVERLLHEQEV 323
+ LE QQ D +A+ E ELE E E+L E ++
Sbjct: 2434 LVQTLEIQRQQSDHDAERLREAIAELEREKEKLQQEAKL 2472
Score = 41.6 bits (96), Expect = 0.001
Identities = 45/210 (21%), Positives = 91/210 (43%), Gaps = 24/210 (11%)
Query: 160 KKKVELQEKSR-WEVLQQEQRLMEEKNKRKKALLAKAIAERSKRTQAETMKLKRIQKELQ 218
+K+++ +EK+ + V Q+EQ L + + + L + R AE + R+Q E +
Sbjct: 2048 QKRLQAEEKAHAFAVQQKEQELQQTLQQEQSVLDQLRGEAEAARRAAEEAEEARVQAERE 2107
Query: 219 ALDDMVSADIGILRNRIDQAS-LDYSYARKRFDRAEAEYIAAKLDIQRKTEIKEQLTEHL 277
A R ++++A L S + RA+A+ A KL + + E +
Sbjct: 2108 AAQS---------RRQVEEAERLKQSAEEQAQARAQAQAAAEKLRKEAEQEAARRAQAEQ 2158
Query: 278 CTIIQQN----ELRKAKKLEELMQQLDVEADEETLELEVEVERLLHEQEVESRRPVVRLE 333
+ Q+ E+ K KK E + + ++E L +++E H++ + L+
Sbjct: 2159 AALRQKQAADAEMEKHKKFAEQTLRQKAQVEQELTTLRLQLEETDHQKNL--------LD 2210
Query: 334 RPFQPAEESVTLEFAKENRKCQEQAVSPKV 363
Q + T E A++ + +E+ S +V
Sbjct: 2211 EELQRLKAEAT-EAARQRSQVEEELFSVRV 2239
Score = 41.2 bits (95), Expect = 0.002
Identities = 42/208 (20%), Positives = 83/208 (39%), Gaps = 8/208 (3%)
Query: 159 EKKKVELQEKSRWEVLQQEQRLMEEKNKRKKALLAKAIAERSKRTQAETMKLKRIQKELQ 218
+ + E+Q K+R + RL E+ R L +A + + E L+ +E +
Sbjct: 1431 QSSEAEIQAKARQAEAAERSRLRIEEEIRVVRLQLEATERQRGGAEGELQALRARAEEAE 1490
Query: 219 ALDDMVSADIGILRNRIDQASLDYSYARKRFDRAEAEYIAAKLDIQRKTEIKEQLTEHLC 278
A + LR ++ D S +++ + A + A+ + R+ + Q E L
Sbjct: 1491 AQKRQAQEEAERLRRQVQ----DESQRKRQAEVELASRVKAEAEAAREKQRALQALEEL- 1545
Query: 279 TIIQQNELRKAKKLEELMQQLDVEADEETLELEVEVERLLHEQEVESRRPVVRLERPFQP 338
+Q E + + E+ + V+ ET + E E L + +LER Q
Sbjct: 1546 -RLQAEEAERRLRQAEVERARQVQVALETAQRSAEAE--LQSKRASFAEKTAQLERSLQE 1602
Query: 339 AEESVTLEFAKENRKCQEQAVSPKVDDQ 366
+V + R+ Q+QA + + ++
Sbjct: 1603 EHVAVAQLREEAERRAQQQAEAERAREE 1630
Score = 37.7 bits (86), Expect = 0.018
Identities = 99/419 (23%), Positives = 156/419 (37%), Gaps = 82/419 (19%)
Query: 21 RWPGPMAQGWAGFSEEE-----LRRLKQTKDPF-----------EPQRRLPAKKS---RQ 61
RW +AQ E E LR +++ DP E + +P S R+
Sbjct: 1191 RWQAVLAQTDVRQRELEQLGRQLRYYRESADPLGAWLQDARRRQEQIQAMPLADSQAVRE 1250
Query: 62 QLQREKALVEQSQKLGLQDGSTSLLPEQLLSAPKQ------RVNVQKPPFSSPTLPSHFT 115
QL++E+AL+E+ ++ G + +Q ++A K Q P +SP
Sbjct: 1251 QLRQEQALLEEIERHGEKVEECQRFAKQYINAIKDYELQLVTYKAQLEPVASPAKKPKVQ 1310
Query: 116 LTSPVGDGQPQGIESQPKELGLENSHDGHNNVEILPPKPDCKLEKKKVELQEKSRWEVLQ 175
S + + + EL S E L + E++ E Q E L
Sbjct: 1311 SGSESVIQEYVDLRTHYSELTTLTSQYIKFISETLRRMEE---EERLAEQQRAEERERLA 1367
Query: 176 QEQRLMEEKNKRKKA-LLAKAIAER-----SKRTQAETMK-----------LKRIQKELQ 218
+ + +E++ + +A AKA AER +R Q E ++ + IQ+ELQ
Sbjct: 1368 EVEAALEKQRQLAEAHAQAKAQAEREAKELQQRMQEEVVRREEAAVDAQQQKRSIQEELQ 1427
Query: 219 ALDDMVSADIGILRNRIDQAS--------------LDYSYARKRFDRAEAEYIAAKLDIQ 264
L A+I + + A L ++ AE E A + +
Sbjct: 1428 QLRQSSEAEIQAKARQAEAAERSRLRIEEEIRVVRLQLEATERQRGGAEGELQALRARAE 1487
Query: 265 RKTEIKEQL---TEHLCTIIQQNELRKAKKLEELMQQLDVEADE-----------ETLEL 310
K Q E L +Q RK + EL ++ EA+ E L L
Sbjct: 1488 EAEAQKRQAQEEAERLRRQVQDESQRKRQAEVELASRVKAEAEAAREKQRALQALEELRL 1547
Query: 311 EV-EVERLLHEQEVESRRPV-VRLERPFQPAE---ESVTLEFAKE----NRKCQEQAVS 360
+ E ER L + EVE R V V LE + AE +S FA++ R QE+ V+
Sbjct: 1548 QAEEAERRLRQAEVERARQVQVALETAQRSAEAELQSKRASFAEKTAQLERSLQEEHVA 1606
Score = 36.6 bits (83), Expect = 0.040
Identities = 73/357 (20%), Positives = 139/357 (38%), Gaps = 59/357 (16%)
Query: 26 MAQGWAGFSEEELRRLKQTKDPFEPQRRLPAKKSRQQLQREKALVEQSQKLGLQDGSTSL 85
+AQ A +EE R + + E Q + + Q+L++++ L E +
Sbjct: 1661 LAQAEAEKQKEEAEREARRRGKAEEQAVRQRELAEQELEKQRQLAEGT------------ 1708
Query: 86 LPEQLLSAPKQRVNVQKPPFSSPTLPSHFTLTSPVGDGQPQGIESQPKELGLENSHDGHN 145
+Q L+A ++ + ++ + G+ Q Q +E + L E +
Sbjct: 1709 -AQQRLAAEQELIRLR--------------AETEQGEQQRQLLEEELARLQREAAAATQK 1753
Query: 146 NVEILPPKPDCKLEKK-----KVELQEKSRWEVLQQEQRLMEEKNK----RKKALLAKAI 196
E+ + E + K +E+SR + +QRL E + ++A +A+
Sbjct: 1754 RQELEAELAKVRAEMEVLLASKARAEEESRSTSEKSKQRLEAEAGRFRELAEEAARLRAL 1813
Query: 197 AERSK-------------RTQAETMKLKRIQKELQALDDMVSADIGILRNRIDQASLDYS 243
AE +K R +AE + +++ +A A+I + + L
Sbjct: 1814 AEEAKRQRQLAEEDAARQRAEAERVLAEKLAAIGEATRLKTEAEIALKEKEAENERLRRL 1873
Query: 244 YARKRFDRAEAEYIAAKLDIQRKTEIKEQLTEHLCTIIQQNELRKAKKLEELMQQLDVEA 303
+ F R E AA Q K +I+E+L + +EL + K L E + +
Sbjct: 1874 AEDEAFQRRRLEEQAA----QHKADIEERLAQ--LRKASDSELERQKGLVEDTLRQRRQV 1927
Query: 304 DEETLELEVEVERLL---HEQEVESRRPVVRLERPFQPAEESVTLEFAKENRKCQEQ 357
+EE L L+ E+ E E+E R E + ++E LE A++ + E+
Sbjct: 1928 EEEILALKASFEKAAAGKAELELELGRIRSNAEDTLR-SKEQAELEAARQRQLAAEE 1983
Score = 36.2 bits (82), Expect = 0.053
Identities = 46/220 (20%), Positives = 97/220 (44%), Gaps = 26/220 (11%)
Query: 159 EKKKVELQEKSRWEVLQQE--QRLMEEKNKRKKALLAKAIAERSKRTQAETMKLKRIQKE 216
E+ K+ + E SR + +E QR ++ + + L +A + K T +T++++R Q +
Sbjct: 2387 ERLKLRVAEMSRAQARAEEDAQRFRKQAEEIGEKLHRTELATQEKVTLVQTLEIQRQQSD 2446
Query: 217 LQALDDMVSADIGILRNRIDQASLDYSYARKRFDRAEAEYIAAKLDIQRKTEIKEQLTEH 276
A + + I L ++ + + + + E + + + +Q +++
Sbjct: 2447 HDA--ERLREAIAELEREKEKLQQEAKLLQLKSE--EMQTVQQEQLLQETQALQQSFLSE 2502
Query: 277 LCTIIQQNEL--RKAKKLEELMQ-------QLDVEADEETLELEVEVERLL--------- 318
+++Q+ ++ KLE+L Q QL E + ++E E +RL+
Sbjct: 2503 KDSLLQRERFIEQEKAKLEQLFQDEVAKAQQLREEQQRQQQQMEQERQRLVASMEEARRR 2562
Query: 319 -HEQEVESRRPVVRLERPFQPAEESVTLEFAKENRKCQEQ 357
HE E RR L++ Q + L A+EN++ +EQ
Sbjct: 2563 QHEAEEGVRRKQEELQQLEQQRRQQEEL-LAEENQRLREQ 2601
Score = 30.0 bits (66), Expect = 3.8
Identities = 17/69 (24%), Positives = 41/69 (59%), Gaps = 5/69 (7%)
Query: 158 LEKKKVELQEKSRWEV-----LQQEQRLMEEKNKRKKALLAKAIAERSKRTQAETMKLKR 212
+E++K +L++ + EV L++EQ+ +++ ++++ L ++ E +R ++R
Sbjct: 2513 IEQEKAKLEQLFQDEVAKAQQLREEQQRQQQQMEQERQRLVASMEEARRRQHEAEEGVRR 2572
Query: 213 IQKELQALD 221
Q+ELQ L+
Sbjct: 2573 KQEELQQLE 2581
Score = 29.6 bits (65), Expect = 4.9
Identities = 60/298 (20%), Positives = 118/298 (39%), Gaps = 23/298 (7%)
Query: 34 SEEELRRLKQTKDPFEPQRRLPAKKSRQQL----QREKALVEQSQKLGLQDGSTSLLPEQ 89
++E+ RRL++ K+ Q + ++ L QR+ + ++++L L+ S +
Sbjct: 2343 AQEQARRLQEDKEQMAQQLAEETQGFQRTLEAERQRQLEMSAEAERLKLRVAEMSRAQAR 2402
Query: 90 LLSAPKQRVNVQKPPFSSPTLPSHFTLTSPVGDGQPQGIESQPKELGLENSHDGHNNVEI 149
QR Q + V Q I+ Q + E + +E
Sbjct: 2403 A-EEDAQRFRKQAEEIGEKLHRTELATQEKVTLVQTLEIQRQQSDHDAERLREAIAELER 2461
Query: 150 LPPKPDCK---LEKKKVELQEKSRWEVLQQEQRLMEEKNKRKKALLAK------AIAERS 200
K + L+ K E+Q + ++LQ+ Q L + K +LL + A+
Sbjct: 2462 EKEKLQQEAKLLQLKSEEMQTVQQEQLLQETQALQQSFLSEKDSLLQRERFIEQEKAKLE 2521
Query: 201 KRTQAETMKLKRIQKELQALDDMVSADIGILRNRIDQASLDYSYARKRFDRAEAEYIAAK 260
+ Q E K +++++E Q + + R R+ AS++ AR+R AE +
Sbjct: 2522 QLFQDEVAKAQQLREEQQRQQQQMEQE----RQRL-VASME--EARRRQHEAEEGVRRKQ 2574
Query: 261 LDIQRKTEIKEQLTEHLCTIIQQNELRKAKKLEELMQQLDVEADEETLELEVEVERLL 318
++Q+ + + Q E L + LR+ +L E + + EE +V + L
Sbjct: 2575 EELQQLEQQRRQQEELLAE--ENQRLREQLQLLEEQHRAALAHSEEVTASQVAATKTL 2630
Database: hs.faa
Posted date: Aug 4, 2009 4:42 PM
Number of letters in database: 18,247,518
Number of sequences in database: 37,866
Lambda K H
0.312 0.128 0.362
Gapped
Lambda K H
0.267 0.0410 0.140
Matrix: BLOSUM62
Gap Penalties: Existence: 11, Extension: 1
Number of Hits to DB: 15,345,726
Number of Sequences: 37866
Number of extensions: 767835
Number of successful extensions: 6046
Number of sequences better than 10.0: 30
Number of HSP's better than 10.0 without gapping: 88
Number of HSP's successfully gapped in prelim test: 624
Number of HSP's that attempted gapping in prelim test: 4309
Number of HSP's gapped (non-prelim): 1933
length of query: 394
length of database: 18,247,518
effective HSP length: 104
effective length of query: 290
effective length of database: 14,309,454
effective search space: 4149741660
effective search space used: 4149741660
T: 11
A: 40
X1: 16 ( 7.2 bits)
X2: 38 (14.6 bits)
X3: 64 (24.7 bits)
S1: 42 (21.9 bits)
S2: 63 (28.9 bits)
Search results were obtained with NCBI BLAST and RefSeq entries.
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Guide to the Human Genome
Copyright © 2010 by Stewart Scherer. All rights reserved.