Search of human proteins with 22547146

Search of human proteins with 22547146

BLASTP 2.2.11 [Jun-05-2005]


Reference: Altschul, Stephen F., Thomas L. Madden, Alejandro A. Schaffer, 
Jinghui Zhang, Zheng Zhang, Webb Miller, and David J. Lipman (1997), 
"Gapped BLAST and PSI-BLAST: a new generation of protein database search
programs",  Nucleic Acids Res. 25:3389-3402.

Query= gi|22547146 F-box and leucine-rich repeat protein 8 [Homo
sapiens]
         (374 letters)

Database: hs.faa 
           37,866 sequences; 18,247,518 total letters

Searching..................................................done

                                                                 Score    E
Sequences producing significant alignments:                      (bits) Value

gi|22547146 F-box and leucine-rich repeat protein 8 [Homo sapiens]    747   0.0  
gi|16306576 F-box and leucine-rich repeat protein 6 isoform 1 [H...    48   1e-05
gi|16306584 F-box and leucine-rich repeat protein 3 [Homo sapiens]     48   2e-05
gi|61742136 F-box and leucine-rich repeat protein 6 isoform 2 [H...    45   8e-05
gi|190194416 F-box and leucine-rich repeat protein 15 [Homo sapi...    43   5e-04
gi|22748931 F-box and leucine-rich repeat protein 14 [Homo sapiens]    41   0.002
gi|8923179 F-box and leucine-rich repeat protein 12 [Homo sapiens]     39   0.010
gi|148922963 F-box and leucine-rich repeat protein 21 [Homo sapi...    37   0.022
gi|16306582 F-box and leucine-rich repeat protein 2 [Homo sapiens]     35   0.14 
gi|6912466 F-box and leucine-rich repeat protein 7 [Homo sapiens]      34   0.24 
gi|11545739 F-box and WD repeat domain containing 4 [Homo sapiens]     32   0.71 
gi|23397500 F-box protein 39 [Homo sapiens]                            32   0.93 
gi|27734755 F-box and leucine-rich repeat protein 20 [Homo sapiens]    32   0.93 
gi|157168349 F-box and leucine-rich repeat protein 19 [Homo sapi...    32   0.93 
gi|61743926 F-box and WD repeat domain containing 7 isoform 3 [H...    32   1.2  
gi|16117781 F-box and WD repeat domain containing 7 isoform 1 [H...    32   1.2  
gi|16117779 F-box and WD repeat domain containing 7 isoform 2 [H...    32   1.2  
gi|51873034 F-box and leucine-rich repeat protein 9 [Homo sapiens]     32   1.2  
gi|16306591 F-box and leucine-rich repeat protein 9 [Homo sapiens]     32   1.2  
gi|239746104 PREDICTED: hypothetical protein XP_002344198 [Homo ...    31   1.6  
gi|30795121 F-box and WD repeat domain containing 8 isoform 2 [H...    31   1.6  
gi|30795123 F-box and WD repeat domain containing 8 isoform 1 [H...    31   1.6  
gi|16306580 F-box and leucine-rich repeat protein 11 [Homo sapiens]    31   2.1  
gi|221307502 WEE1 tyrosine kinase isoform 2 [Homo sapiens]             31   2.1  
gi|4507917 WEE1 tyrosine kinase isoform 1 [Homo sapiens]               31   2.1  
gi|161333854 F-box and leucine-rich repeat protein 13 isoform 2 ...    31   2.1  
gi|161333852 F-box and leucine-rich repeat protein 13 isoform 1 ...    31   2.1  
gi|157743247 F-box protein 45 [Homo sapiens]                           31   2.1  
gi|239744931 PREDICTED: hypothetical protein XP_002343311 [Homo ...    30   2.7  
gi|30089926 F-box only protein 11 isoform 1 [Homo sapiens]             30   2.7  

>gi|22547146 F-box and leucine-rich repeat protein 8 [Homo sapiens]
          Length = 374

 Score =  747 bits (1928), Expect = 0.0
 Identities = 374/374 (100%), Positives = 374/374 (100%)

Query: 1   MAEPGEGLPEEVLALIFRHLSLRDRAAAARVCRAWAAAATCSAVWHDTKISCECELEGML 60
           MAEPGEGLPEEVLALIFRHLSLRDRAAAARVCRAWAAAATCSAVWHDTKISCECELEGML
Sbjct: 1   MAEPGEGLPEEVLALIFRHLSLRDRAAAARVCRAWAAAATCSAVWHDTKISCECELEGML 60

Query: 61  PPYLSACLDHIHNLRLEFEPSRKPSRRAAIELLMVLAGRAPGLRGLRLECRGEKPLFDAG 120
           PPYLSACLDHIHNLRLEFEPSRKPSRRAAIELLMVLAGRAPGLRGLRLECRGEKPLFDAG
Sbjct: 61  PPYLSACLDHIHNLRLEFEPSRKPSRRAAIELLMVLAGRAPGLRGLRLECRGEKPLFDAG 120

Query: 121 RDVLEAVHAVCGAASQLRHLDLRRLSFTLDDALVLQAARSCPELHSLFLDNSTLVGSVGP 180
           RDVLEAVHAVCGAASQLRHLDLRRLSFTLDDALVLQAARSCPELHSLFLDNSTLVGSVGP
Sbjct: 121 RDVLEAVHAVCGAASQLRHLDLRRLSFTLDDALVLQAARSCPELHSLFLDNSTLVGSVGP 180

Query: 181 GSVLELLEACPRLRALGLHLASLSHAILEALAAPDRAPFALLALRCACPEDARASPLPNE 240
           GSVLELLEACPRLRALGLHLASLSHAILEALAAPDRAPFALLALRCACPEDARASPLPNE
Sbjct: 181 GSVLELLEACPRLRALGLHLASLSHAILEALAAPDRAPFALLALRCACPEDARASPLPNE 240

Query: 241 AWVALRRRHPGLAVELELEPALPAESVTRVLQPAVPVAALRLNLSGDTVGPVRFAAHHYA 300
           AWVALRRRHPGLAVELELEPALPAESVTRVLQPAVPVAALRLNLSGDTVGPVRFAAHHYA
Sbjct: 241 AWVALRRRHPGLAVELELEPALPAESVTRVLQPAVPVAALRLNLSGDTVGPVRFAAHHYA 300

Query: 301 ATLCALEVRAAASAELNAALEELAARCAALREVHCFCVVSHSVLDAFRAHCPRLRTYTLK 360
           ATLCALEVRAAASAELNAALEELAARCAALREVHCFCVVSHSVLDAFRAHCPRLRTYTLK
Sbjct: 301 ATLCALEVRAAASAELNAALEELAARCAALREVHCFCVVSHSVLDAFRAHCPRLRTYTLK 360

Query: 361 LTREPHPWRPTLVA 374
           LTREPHPWRPTLVA
Sbjct: 361 LTREPHPWRPTLVA 374


>gi|16306576 F-box and leucine-rich repeat protein 6 isoform 1 [Homo
           sapiens]
          Length = 539

 Score = 48.1 bits (113), Expect = 1e-05
 Identities = 70/245 (28%), Positives = 99/245 (40%), Gaps = 42/245 (17%)

Query: 5   GEGLPEEVLALIFRHLSLRDR-----AAAARVCRAWAAAATCSAVWHDTKISCECELEGM 59
           G+ +P E+L  IF  L   D        AARVCR W  AA+  A+WH   +S        
Sbjct: 112 GDRIPLEILVQIFGLLVAADGPMPFLGRAARVCRRWQEAASQPALWHTVTLSSP------ 165

Query: 60  LPPYLSACLDHIHNLRLEFEPSR---KPSRRAAIELLMVLAGRAPGLRGLRLECRGEKPL 116
                           L   P++   K  ++    L  ++  R   L+ L L     +  
Sbjct: 166 ----------------LVGRPAKGGVKAEKKLLASLEWLMPNRFSQLQRLTLIHWKSQV- 208

Query: 117 FDAGRDVLEAVHAVCGAASQLRHLDLRRLSFTLDDALVLQAARSCPELHSLFLDNSTLVG 176
                 VL+ V   C    +L  L L        DALV+  A++C +LHSL L +S +V 
Sbjct: 209 ----HPVLKLVGECC---PRLTFLKLSGCHGVTADALVM-LAKACCQLHSLDLQHS-MVE 259

Query: 177 SVGPGSVLELLEACPRLRALGLHLASLSHAILEALAAPDRAPFALLALRCACPEDARASP 236
           S    S LE  EA  R+R L L  +S + AIL AL         +L +      ++    
Sbjct: 260 STAVVSFLE--EAGSRMRKLWLTYSSQTTAILGALLGSCCPQLQVLEVSTGINRNSIPLQ 317

Query: 237 LPNEA 241
           LP EA
Sbjct: 318 LPVEA 322


>gi|16306584 F-box and leucine-rich repeat protein 3 [Homo sapiens]
          Length = 428

 Score = 47.8 bits (112), Expect = 2e-05
 Identities = 90/371 (24%), Positives = 131/371 (35%), Gaps = 53/371 (14%)

Query: 8   LPEEVLALIFRHLSLRDRAAAARVCRAWAAAATCSAVWHDTKISCECELEGMLPPYLSAC 67
           L ++++  +F++L L DRA A++VCR W        +W       E EL      YL A 
Sbjct: 39  LLQDIILQVFKYLPLLDRAHASQVCRNWNQVFHMPDLWR----CFEFELNQPATSYLKAT 94

Query: 68  LDHI-------HNLRLEF----EPSRKPSRRAAIELLMVLAGRAPGLRGLRLECRGEKPL 116
              +       H+  L++      S K S  AA ++L  L   +  L+ L L        
Sbjct: 95  HPELIKQIIKRHSNHLQYVSFKVDSSKESAEAACDILSQLVNCS--LKTLGLISTARPSF 152

Query: 117 FDAGR----DVLEAVHAVCGAASQLRHLD-------LRRLSFTLDDALVLQAARSCPELH 165
            D  +      L  V     + S L+  D       L+ L     D L L    SCP   
Sbjct: 153 MDLPKSHFISALTVVFVNSKSLSSLKIDDTPVDDPSLKVLVANNSDTLKLLKMSSCPH-- 210

Query: 166 SLFLDNSTLVGSVGPGSVLELLEACPRLRALGLHLASLSHAILEALAAPDRAPFALLALR 225
                       V P  +L + + C  LR L L+   LS  +L AL++        L + 
Sbjct: 211 ------------VSPAGILCVADQCHGLRELALNYHLLSDELLLALSSEKHVRLEHLRID 258

Query: 226 CAC--PEDARASPLPNEAWVALRRRHPGLAVELELEPALPAESVTRVLQPAVPVAALRL- 282
                P       +   +W A  R  P   V L +   L  E      +  +P   L   
Sbjct: 259 VVSENPGQTHFHTIQKSSWDAFIRHSP--KVNLVMYFFLYEEEFDPFFRYEIPATHLYFG 316

Query: 283 -NLSGDTVGPVRFAAHHYAATLCALEVRAAASAELNAALEELAARCAALREVHC-FCVVS 340
            ++S D +G V          L  L V A     L+  L  +A RC  L  +    C VS
Sbjct: 317 RSVSKDVLGRVGMT----CPRLVELVVCANGLRPLDEELIRIAERCKNLSAIGLGECEVS 372

Query: 341 HSVLDAFRAHC 351
            S    F   C
Sbjct: 373 CSAFVEFVKMC 383


>gi|61742136 F-box and leucine-rich repeat protein 6 isoform 2 [Homo
           sapiens]
          Length = 533

 Score = 45.4 bits (106), Expect = 8e-05
 Identities = 67/245 (27%), Positives = 95/245 (38%), Gaps = 48/245 (19%)

Query: 5   GEGLPEEVLALIFRHLSLRDR-----AAAARVCRAWAAAATCSAVWHDTKISCECELEGM 59
           G+ +P E+L  IF  L   D        AARVCR W  AA+  A+WH   +S        
Sbjct: 112 GDRIPLEILVQIFGLLVAADGPMPFLGRAARVCRRWQEAASQPALWHTVTLSSP------ 165

Query: 60  LPPYLSACLDHIHNLRLEFEPSR---KPSRRAAIELLMVLAGRAPGLRGLRLECRGEKPL 116
                           L   P++   K  ++    L  ++  R   L+ L L        
Sbjct: 166 ----------------LVGRPAKGGVKAEKKLLASLEWLMPNRFSQLQRLTL-------- 201

Query: 117 FDAGRDVLEAVHAVCGAASQLRHLDLRRLSFTLDDALVLQAARSCPELHSLFLDNSTLVG 176
                 +      V     +L  L L        DALV+  A++C +LHSL L +S +V 
Sbjct: 202 ------IHWKSQLVGECCPRLTFLKLSGCHGVTADALVM-LAKACCQLHSLDLQHS-MVE 253

Query: 177 SVGPGSVLELLEACPRLRALGLHLASLSHAILEALAAPDRAPFALLALRCACPEDARASP 236
           S    S LE  EA  R+R L L  +S + AIL AL         +L +      ++    
Sbjct: 254 STAVVSFLE--EAGSRMRKLWLTYSSQTTAILGALLGSCCPQLQVLEVSTGINRNSIPLQ 311

Query: 237 LPNEA 241
           LP EA
Sbjct: 312 LPVEA 316


>gi|190194416 F-box and leucine-rich repeat protein 15 [Homo
           sapiens]
          Length = 300

 Score = 42.7 bits (99), Expect = 5e-04
 Identities = 30/66 (45%), Positives = 36/66 (54%), Gaps = 7/66 (10%)

Query: 135 SQLRHLDLRRLSFTLD----DALVLQAARSCPELHSLFLDNSTLVGSVGPGSVLELLEAC 190
           +Q R   LR LS  ++    DA V + AR+CPELH L L     VGS G   V  L E C
Sbjct: 188 AQRRGAGLRSLSLAVNANVGDAAVQELARNCPELHHLDLTGCLRVGSDG---VRTLAEYC 244

Query: 191 PRLRAL 196
           P LR+L
Sbjct: 245 PVLRSL 250



 Score = 30.8 bits (68), Expect = 2.1
 Identities = 24/73 (32%), Positives = 31/73 (42%), Gaps = 3/73 (4%)

Query: 126 AVHAVCGAASQLRHLDLRRLSFTLDDALVLQAARSCPELHSLFLDNSTLVGSVGPGSVLE 185
           A+  +      L  LDL       D+A+V  A R    L SL L    +  +VG  +V E
Sbjct: 157 ALRGLADRCPALEELDLTACRQLKDEAIVYLAQRRGAGLRSLSL---AVNANVGDAAVQE 213

Query: 186 LLEACPRLRALGL 198
           L   CP L  L L
Sbjct: 214 LARNCPELHHLDL 226


>gi|22748931 F-box and leucine-rich repeat protein 14 [Homo
          sapiens]
          Length = 418

 Score = 41.2 bits (95), Expect = 0.002
 Identities = 18/35 (51%), Positives = 25/35 (71%)

Query: 11 EVLALIFRHLSLRDRAAAARVCRAWAAAATCSAVW 45
          E+LA+IF +L +RD+  AA+VC AW  AA   +VW
Sbjct: 11 ELLAMIFGYLDVRDKGRAAQVCTAWRDAAYHKSVW 45


>gi|8923179 F-box and leucine-rich repeat protein 12 [Homo sapiens]
          Length = 326

 Score = 38.5 bits (88), Expect = 0.010
 Identities = 33/109 (30%), Positives = 47/109 (43%), Gaps = 14/109 (12%)

Query: 8   LPEEVLALIFRHLSLRDRAAAARVCRAWAAAATCSAVWHDTKISCECELEGMLPPYLSAC 67
           LP+ VL  IF +L +RDR   +RVC  W        +W    ++    L  M P  +   
Sbjct: 7   LPDSVLLEIFSYLPVRDRIRISRVCHRWKRLVDDRWLWRHVDLT----LYTMRPKVMWHL 62

Query: 68  L-----DHIHNLRLE---FEPSRKPSRRAAIELLMVLAGRAPGLRGLRL 108
           L       +H+LR+    F  S+ P    A  LL  L  + P L+ L L
Sbjct: 63  LRRYMASRLHSLRMGGYLFSGSQAPQLSPA--LLRALGQKCPNLKRLCL 109



 Score = 30.0 bits (66), Expect = 3.5
 Identities = 25/78 (32%), Positives = 32/78 (41%), Gaps = 4/78 (5%)

Query: 138 RHLDLRRLSFTLDDALVLQAARSCPELHSLFLDNSTLVGSVGPGSVLELLEA----CPRL 193
           RH+DL   +        L        LHSL +      GS  P     LL A    CP L
Sbjct: 45  RHVDLTLYTMRPKVMWHLLRRYMASRLHSLRMGGYLFSGSQAPQLSPALLRALGQKCPNL 104

Query: 194 RALGLHLASLSHAILEAL 211
           + L LH+A LS   + +L
Sbjct: 105 KRLCLHVADLSMVPITSL 122


>gi|148922963 F-box and leucine-rich repeat protein 21 [Homo
           sapiens]
          Length = 434

 Score = 37.4 bits (85), Expect = 0.022
 Identities = 85/372 (22%), Positives = 128/372 (34%), Gaps = 45/372 (12%)

Query: 8   LPEEVLALIFRHLSLRDRAAAARVCRAWAAAATCSAVWH----DTKISCECELEGMLPPY 63
           LP  V+  IF++L L DRA A+ VCR W      S +W     +   S     +   P  
Sbjct: 45  LPHHVVLQIFQYLPLLDRACASSVCRRWNEVFHISDLWRKFEFELNQSATSSFKSTHPDL 104

Query: 64  LSACLD----HIHNLRLEFEPSRKPSRRAAIELLMVLAGRAPGLRGLRLECRGEKPLFDA 119
           +   +     H+  +  + + S + S  AA ++L  L   +    GL       KP F  
Sbjct: 105 IQQIIKKHFAHLQYVSFKVDSSAE-SAEAACDILSQLVNCSIQTLGL---ISTAKPSFMN 160

Query: 120 GRD-----VLEAVHAVCGAASQLRHLD-------LRRLSFTLDDALVLQAARSCPELHSL 167
             +      L  V     + S ++  D       L+ L     D L L    SCP + S 
Sbjct: 161 VSESHFVSALTVVFINSKSLSSIKIEDTPVDDPSLKILVANNSDTLRLPKMSSCPHVSS- 219

Query: 168 FLDNSTLVGSVGPGSVLELLEACPRLRALGLHLASLSHAILEALAAPDRAPFALLALRCA 227
                          +L + + C  LR L L+   L+  +  AL++        L +   
Sbjct: 220 -------------DGILCVADRCQGLRELALNYYILTDELFLALSSETHVNLEHLRIDVV 266

Query: 228 C--PEDARASPLPNEAWVALRRRHPGLAVELELEPALPAESVTRVLQPAVPVAALRLNLS 285
              P   +   +   +W AL +  P + V +     L  E      +   PV  L    S
Sbjct: 267 SENPGQIKFHAVKKHSWDALIKHSPRVNVVMHF--FLYEEEFETFFKEETPVTHLYFGRS 324

Query: 286 GDTVGPVRFAAHHYAATLCALEVRAAASAELNAALEELAARCAALREVHCF-CVVSHSVL 344
              V   R   +     L  L V A     L+  L  +A  C  L  +    C VS S  
Sbjct: 325 VSKVVLGRVGLN--CPRLIELVVCANDLQPLDNELICIAEHCTNLTALGLSKCEVSCSAF 382

Query: 345 DAFRAHCPRLRT 356
             F   C R  T
Sbjct: 383 IRFVRLCERRLT 394


>gi|16306582 F-box and leucine-rich repeat protein 2 [Homo sapiens]
          Length = 423

 Score = 34.7 bits (78), Expect = 0.14
 Identities = 80/357 (22%), Positives = 132/357 (36%), Gaps = 57/357 (15%)

Query: 8   LPEEVLALIFRHLSLRDRAAAARVCRAWAAAATCSAVWHDTKI-SCECELEGMLPPYLSA 66
           LP+E+L  IF  L +      A++ +AW   A   + W    + + + ++EG +      
Sbjct: 15  LPKELLLRIFSFLDIVTLCRCAQISKAWNILALDGSNWQRIDLFNFQIDVEGRV------ 68

Query: 67  CLDHIHNLRLEFEPSRKPSRRAAIELLMVLAGRAPGLRGLRLECRGEKPLFDAGRDVLEA 126
               + N+          S+R    L      R   LRG    C G       G   L+ 
Sbjct: 69  ----VENI----------SKRCGGFL------RKLSLRG----CIG------VGDSSLKT 98

Query: 127 VHAVCGAASQLRHLDLRRLSFTLDDALVLQAARSCPELHSLFLDNSTLVGSVGPGSVLEL 186
               C     + HL+L   +  + D+     +R C +L  L L +     S+   S+  +
Sbjct: 99  FAQNC---RNIEHLNLNGCT-KITDSTCYSLSRFCSKLKHLDLTSCV---SITNSSLKGI 151

Query: 187 LEACPRLRALGLHLAS-LSHAILEALAAPDRAPFALLALRCACPEDARASPLPNEAWVAL 245
            E C  L  L L     ++   +EAL    R   ALL   C   ED     + N      
Sbjct: 152 SEGCRNLEYLNLSWCDQITKDGIEALVRGCRGLKALLLRGCTQLEDEALKHIQNYC---- 207

Query: 246 RRRHPGLAVELELEPALPAESVTRVLQPAVPVAALRLNLSGDTVGPVRFAAHHYAATLCA 305
              H  +++ L+    +  E V ++ +    + AL L+   +       A       L  
Sbjct: 208 ---HELVSLNLQSCSRITDEGVVQICRGCHRLQALCLSGCSNLTDASLTALGLNCPRLQI 264

Query: 306 LEVRAAASAELNAALEELAARCAALREV---HCFCVVSHSVLDAFRAHCPRLRTYTL 359
           LE  A  S   +A    LA  C  L ++    C  +++ S L     HCP+L+  +L
Sbjct: 265 LEA-ARCSHLTDAGFTLLARNCHELEKMDLEECI-LITDSTLIQLSIHCPKLQALSL 319


>gi|6912466 F-box and leucine-rich repeat protein 7 [Homo sapiens]
          Length = 491

 Score = 33.9 bits (76), Expect = 0.24
 Identities = 42/160 (26%), Positives = 59/160 (36%), Gaps = 10/160 (6%)

Query: 8   LPEEVLALIFRHLSLRDRAAAARVCRAWAAAATCSAVWHDTKISCE-CELEGMLPPYLSA 66
           LP+  +  IF  L        ARVCR W   A    +W   +++ E   ++  L      
Sbjct: 117 LPDHSMVQIFSFLPTNQLCRCARVCRRWYNLAWDPRLWRTIRLTGETINVDRALKVLTRR 176

Query: 67  CLDHIHNLRLEFEP-SRKPSRRAAIELLMVLAGRAPGLRGLRLECRGEKPLFDAGRDVLE 125
                 N+ L  E  +    RR     L  +A   P LR  RLE  G   + +      E
Sbjct: 177 LCQDTPNVCLMLETVTVSGCRRLTDRGLYTIAQCCPELR--RLEVSGCYNISN------E 228

Query: 126 AVHAVCGAASQLRHLDLRRLSFTLDDALVLQAARSCPELH 165
           AV  V      L HLD+   S     +L  +A+     LH
Sbjct: 229 AVFDVVSLCPNLEHLDVSGCSKVTCISLTREASIKLSPLH 268


>gi|11545739 F-box and WD repeat domain containing 4 [Homo
          sapiens]
          Length = 412

 Score = 32.3 bits (72), Expect = 0.71
 Identities = 15/38 (39%), Positives = 21/38 (55%)

Query: 8  LPEEVLALIFRHLSLRDRAAAARVCRAWAAAATCSAVW 45
          LPEE+L LI  +L +R     A+VCR      +C  +W
Sbjct: 31 LPEELLLLICSYLDMRALGRLAQVCRWLRRFTSCDLLW 68


>gi|23397500 F-box protein 39 [Homo sapiens]
          Length = 442

 Score = 32.0 bits (71), Expect = 0.93
 Identities = 67/310 (21%), Positives = 114/310 (36%), Gaps = 50/310 (16%)

Query: 8   LPEEVLALIFRHLSLRDRAAAARVCRAWAAAATCSAVWHDTKISCE--------CELEGM 59
           LP+  L  +F  L  RDR+ AA VCR W      + +W    I+           E+E  
Sbjct: 19  LPDLCLCRVFWWLGDRDRSRAALVCRKWNQMMYSAELWRYRTITFSGRPSRVHASEVESA 78

Query: 60  LPPYLSACLDHIHNLRLEFEPSRKPSRRAAIELLMVLAGRAPGLRGLRLEC--RGEKPLF 117
           +  Y+     ++ +L ++F     P      +   V       +RGL L C  +    L 
Sbjct: 79  V-WYVKKFGRYLEHLEVKF---MNPYNAVLTKKFQVT------MRGL-LSCLSKSNNRLK 127

Query: 118 DAGRDVLEAVHAVCGAASQLRHLDLRRLSFTLD------DALVLQAAR-----SCPELHS 166
                 LE    V    + +R   +  LSF L       D L L+ AR      C  L S
Sbjct: 128 SLSIQYLELDRLVW--RNSIRSSFISSLSFFLKKMGKRLDYLNLKGARLTVEQGCQILDS 185

Query: 167 L-FLDNSTLVGSV-------------GPGSVLELLEACPRLRALGLHLASLSHAILEALA 212
           L ++ N  ++  +                   + +     L +L L+   +S  +LE L 
Sbjct: 186 LSYMRNENVISELNIEDYFSHHLAVYNSPQFKKTMSTFHNLVSLNLNYNCISDELLENL- 244

Query: 213 APDRAPFALLALRCACPEDARASPLPNEAWVALRRRHPGLAVELELEPALPAESVTRVLQ 272
             + +    + ++C    D     +   +W  L R+   L V    E  +  E + R+L 
Sbjct: 245 CENASTLRTINIKCHV-HDPHGQVIWGMSWAKLARQATNLKVNFFFERIMKYERLARILL 303

Query: 273 PAVPVAALRL 282
             +P+ ++ L
Sbjct: 304 QEIPIRSISL 313


>gi|27734755 F-box and leucine-rich repeat protein 20 [Homo sapiens]
          Length = 436

 Score = 32.0 bits (71), Expect = 0.93
 Identities = 48/197 (24%), Positives = 74/197 (37%), Gaps = 28/197 (14%)

Query: 8   LPEEVLALIFRHLSLRDRAAAARVCRAWAAAATCSAVWHDTKI-SCECELEGMLPPYLS- 65
           LP+E+L  IF  L +      A+V RAW   A   + W    +   + ++EG +   +S 
Sbjct: 28  LPKELLLRIFSFLDVVTLCRCAQVSRAWNVLALDGSNWQRIDLFDFQRDIEGRVVENISK 87

Query: 66  ACLDHIHNLRLEFEPSRKPSRRAAIELLMVLAGRAPGLRGLRLECRGEKPLFDAGRDVLE 125
            C   +  L L                   L      LR     CR  + L   G    +
Sbjct: 88  RCGGFLRKLSLR----------------GCLGVGDNALRTFAQNCRNIEVLNLNG--CTK 129

Query: 126 AVHAVCGA----ASQLRHLDLRRLSFTLDDALVLQAARSCPELHSLFLDNSTLVGSVGPG 181
              A C +     S+LRHLDL   + ++ +  +   +  CP L  L   N +    V   
Sbjct: 130 TTDATCTSLSKFCSKLRHLDLASCT-SITNMSLKALSEGCPLLEQL---NISWCDQVTKD 185

Query: 182 SVLELLEACPRLRALGL 198
            +  L+  C  L+AL L
Sbjct: 186 GIQALVRGCGGLKALFL 202


>gi|157168349 F-box and leucine-rich repeat protein 19 [Homo
           sapiens]
          Length = 694

 Score = 32.0 bits (71), Expect = 0.93
 Identities = 17/58 (29%), Positives = 25/58 (43%), Gaps = 3/58 (5%)

Query: 8   LPEEVLALIFRHLSLRDRAAAARVCRAWAAAATCSAVWHDTKISCECELEGMLPPYLS 65
           LP      +F+HL  R+     RVCR W+       +W    +S     + + PP LS
Sbjct: 424 LPRAAWLRVFQHLGPRELCICMRVCRTWSRWCYDKRLWPRMDLS---RRKSLTPPMLS 478


>gi|61743926 F-box and WD repeat domain containing 7 isoform 3 [Homo
           sapiens]
          Length = 589

 Score = 31.6 bits (70), Expect = 1.2
 Identities = 16/55 (29%), Positives = 27/55 (49%), Gaps = 5/55 (9%)

Query: 8   LPEEVLALIFRHLSLRDRAAAARVCRAWAAAATCSAVWHDTKISCECELEGMLPP 62
           LP+E+   +   L  +D   AA+ CR W   A  + +W +     +C+ EG+  P
Sbjct: 166 LPKELALYVLSFLEPKDLLQAAQTCRYWRILAEDNLLWRE-----KCKEEGIDEP 215


>gi|16117781 F-box and WD repeat domain containing 7 isoform 1 [Homo
           sapiens]
          Length = 707

 Score = 31.6 bits (70), Expect = 1.2
 Identities = 16/55 (29%), Positives = 27/55 (49%), Gaps = 5/55 (9%)

Query: 8   LPEEVLALIFRHLSLRDRAAAARVCRAWAAAATCSAVWHDTKISCECELEGMLPP 62
           LP+E+   +   L  +D   AA+ CR W   A  + +W +     +C+ EG+  P
Sbjct: 284 LPKELALYVLSFLEPKDLLQAAQTCRYWRILAEDNLLWRE-----KCKEEGIDEP 333


>gi|16117779 F-box and WD repeat domain containing 7 isoform 2 [Homo
           sapiens]
          Length = 627

 Score = 31.6 bits (70), Expect = 1.2
 Identities = 16/55 (29%), Positives = 27/55 (49%), Gaps = 5/55 (9%)

Query: 8   LPEEVLALIFRHLSLRDRAAAARVCRAWAAAATCSAVWHDTKISCECELEGMLPP 62
           LP+E+   +   L  +D   AA+ CR W   A  + +W +     +C+ EG+  P
Sbjct: 204 LPKELALYVLSFLEPKDLLQAAQTCRYWRILAEDNLLWRE-----KCKEEGIDEP 253


>gi|51873034 F-box and leucine-rich repeat protein 9 [Homo sapiens]
          Length = 223

 Score = 31.6 bits (70), Expect = 1.2
 Identities = 33/95 (34%), Positives = 44/95 (46%), Gaps = 7/95 (7%)

Query: 136 QLRHLDLRRLSFTLDDALVLQAARSCPELHSLFLDNSTLVGSVGPGSVLELLEACPRLRA 195
           QLR L L  L    D+ LV   AR CP L  L L + + +   G     +   + PRL+ 
Sbjct: 101 QLRQLSLSLLPELTDNGLVA-VARGCPSLEHLALSHCSRLSDKG---WAQAASSWPRLQ- 155

Query: 196 LGLHLASLSHAILEALAAPDRAPFALLALRCA-CP 229
             L+L+S S  I + L A  +A   L  L  A CP
Sbjct: 156 -HLNLSSCSQLIEQTLDAIGQACRQLRVLDVATCP 189


>gi|16306591 F-box and leucine-rich repeat protein 9 [Homo sapiens]
          Length = 223

 Score = 31.6 bits (70), Expect = 1.2
 Identities = 33/95 (34%), Positives = 44/95 (46%), Gaps = 7/95 (7%)

Query: 136 QLRHLDLRRLSFTLDDALVLQAARSCPELHSLFLDNSTLVGSVGPGSVLELLEACPRLRA 195
           QLR L L  L    D+ LV   AR CP L  L L + + +   G     +   + PRL+ 
Sbjct: 101 QLRQLSLSLLPELTDNGLVA-VARGCPSLEHLALSHCSRLSDKG---WAQAASSWPRLQ- 155

Query: 196 LGLHLASLSHAILEALAAPDRAPFALLALRCA-CP 229
             L+L+S S  I + L A  +A   L  L  A CP
Sbjct: 156 -HLNLSSCSQLIEQTLDAIGQACRQLRVLDVATCP 189


>gi|239746104 PREDICTED: hypothetical protein XP_002344198 [Homo
           sapiens]
          Length = 398

 Score = 31.2 bits (69), Expect = 1.6
 Identities = 24/66 (36%), Positives = 27/66 (40%), Gaps = 2/66 (3%)

Query: 222 LALRCACPEDARASPLPNEAWVALRRRHPGLAVELELEPALPAESVTRVLQPAVPVAALR 281
           LALRCA PE  R S  P+     L  R  GL  EL L P+      +  L      A  R
Sbjct: 248 LALRCALPE--RGSRTPSTRSAVLSGRVAGLGTELTLTPSSRRAHGSHALSSERQAAPTR 305

Query: 282 LNLSGD 287
              S D
Sbjct: 306 AFCSAD 311


>gi|30795121 F-box and WD repeat domain containing 8 isoform 2 [Homo
           sapiens]
          Length = 532

 Score = 31.2 bits (69), Expect = 1.6
 Identities = 16/54 (29%), Positives = 26/54 (48%), Gaps = 5/54 (9%)

Query: 8   LPEEVLALIFRHLSLRDRAAAARVCRAWAAAATCSAVWHDTKISCECELEGMLP 61
           LP E+   IF++L  ++    A+V + W   A    +W+       C+ EG LP
Sbjct: 53  LPYELAINIFQYLDRKELGRCAQVSKTWKVIAEDEVLWYRL-----CQQEGHLP 101


>gi|30795123 F-box and WD repeat domain containing 8 isoform 1 [Homo
           sapiens]
          Length = 598

 Score = 31.2 bits (69), Expect = 1.6
 Identities = 16/54 (29%), Positives = 26/54 (48%), Gaps = 5/54 (9%)

Query: 8   LPEEVLALIFRHLSLRDRAAAARVCRAWAAAATCSAVWHDTKISCECELEGMLP 61
           LP E+   IF++L  ++    A+V + W   A    +W+       C+ EG LP
Sbjct: 119 LPYELAINIFQYLDRKELGRCAQVSKTWKVIAEDEVLWYRL-----CQQEGHLP 167


>gi|16306580 F-box and leucine-rich repeat protein 11 [Homo sapiens]
          Length = 1162

 Score = 30.8 bits (68), Expect = 2.1
 Identities = 27/101 (26%), Positives = 43/101 (42%), Gaps = 9/101 (8%)

Query: 8   LPEEVLALIFRHLSLRDRAAAARVCRAWAAAATCSAVWHDTKISCECELEGMLPPYLSAC 67
           +  EV   +FR+LS R+     RVC+ W        +W  TKI      + ++P  LS  
Sbjct: 893 MQREVWMSVFRYLSRRELCECMRVCKTWYKWCCDKRLW--TKIDLS-RCKAIVPQALSGI 949

Query: 68  LDHIHNLRLEFEPSRKPSRRAAIELLMVLAGRAPGLRGLRL 108
           +     + L+   +    ++     L  L  R PGL+ L L
Sbjct: 950 IKR-QPVSLDLSWTNISKKQ-----LTWLVNRLPGLKDLLL 984


>gi|221307502 WEE1 tyrosine kinase isoform 2 [Homo sapiens]
          Length = 432

 Score = 30.8 bits (68), Expect = 2.1
 Identities = 31/113 (27%), Positives = 47/113 (41%), Gaps = 13/113 (11%)

Query: 8   LPEEVLALIFRHLSLRDRAAAAR--VCRAWAAAATCSA-VWHDTKISCECELEGMLP--- 61
           L  EVL   + HL   D  A A   VC A A     +   WH+ +       +G LP   
Sbjct: 269 LANEVLQENYTHLPKADIFALALTVVCAAGAEPLPRNGDQWHEIR-------QGRLPRIP 321

Query: 62  PYLSACLDHIHNLRLEFEPSRKPSRRAAIELLMVLAGRAPGLRGLRLECRGEK 114
             LS     +  + +  +P R+PS  A ++  ++L+        LR+E   EK
Sbjct: 322 QVLSQEFTELLKVMIHPDPERRPSAMALVKHSVLLSASRKSAEQLRIELNAEK 374


>gi|4507917 WEE1 tyrosine kinase isoform 1 [Homo sapiens]
          Length = 646

 Score = 30.8 bits (68), Expect = 2.1
 Identities = 31/113 (27%), Positives = 47/113 (41%), Gaps = 13/113 (11%)

Query: 8   LPEEVLALIFRHLSLRDRAAAAR--VCRAWAAAATCSA-VWHDTKISCECELEGMLP--- 61
           L  EVL   + HL   D  A A   VC A A     +   WH+ +       +G LP   
Sbjct: 483 LANEVLQENYTHLPKADIFALALTVVCAAGAEPLPRNGDQWHEIR-------QGRLPRIP 535

Query: 62  PYLSACLDHIHNLRLEFEPSRKPSRRAAIELLMVLAGRAPGLRGLRLECRGEK 114
             LS     +  + +  +P R+PS  A ++  ++L+        LR+E   EK
Sbjct: 536 QVLSQEFTELLKVMIHPDPERRPSAMALVKHSVLLSASRKSAEQLRIELNAEK 588


>gi|161333854 F-box and leucine-rich repeat protein 13 isoform 2
           [Homo sapiens]
          Length = 690

 Score = 30.8 bits (68), Expect = 2.1
 Identities = 21/74 (28%), Positives = 37/74 (50%), Gaps = 6/74 (8%)

Query: 8   LPEEVLALIFRHLSLRDRAAAARVCRAWAAAATCSAVWHDTKISCECELEGMLP-PYLSA 66
           LPE  +  IF +LSL+D     +V  AW      +++W+    S    ++ ++P  Y+ +
Sbjct: 158 LPERAILQIFFYLSLKDVIICGQVNHAWMLMTQLNSLWNAIDFS---SVKNVIPDKYIVS 214

Query: 67  CLD--HIHNLRLEF 78
            L    ++ LRL F
Sbjct: 215 TLQRWRLNVLRLNF 228


>gi|161333852 F-box and leucine-rich repeat protein 13 isoform 1
           [Homo sapiens]
          Length = 735

 Score = 30.8 bits (68), Expect = 2.1
 Identities = 21/74 (28%), Positives = 37/74 (50%), Gaps = 6/74 (8%)

Query: 8   LPEEVLALIFRHLSLRDRAAAARVCRAWAAAATCSAVWHDTKISCECELEGMLP-PYLSA 66
           LPE  +  IF +LSL+D     +V  AW      +++W+    S    ++ ++P  Y+ +
Sbjct: 158 LPERAILQIFFYLSLKDVIICGQVNHAWMLMTQLNSLWNAIDFS---SVKNVIPDKYIVS 214

Query: 67  CLD--HIHNLRLEF 78
            L    ++ LRL F
Sbjct: 215 TLQRWRLNVLRLNF 228


>gi|157743247 F-box protein 45 [Homo sapiens]
          Length = 286

 Score = 30.8 bits (68), Expect = 2.1
 Identities = 14/34 (41%), Positives = 19/34 (55%)

Query: 2  AEPGEGLPEEVLALIFRHLSLRDRAAAARVCRAW 35
          A  G  LP  VL L+F +L L +  + A VC+ W
Sbjct: 33 AGAGGRLPSRVLELVFSYLELSELRSCALVCKHW 66


>gi|239744931 PREDICTED: hypothetical protein XP_002343311 [Homo
           sapiens]
          Length = 173

 Score = 30.4 bits (67), Expect = 2.7
 Identities = 22/86 (25%), Positives = 41/86 (47%), Gaps = 4/86 (4%)

Query: 36  AAAATCSAVWHDTKISCECELEGMLPPYLSACLDHIHNLRLEFEPSRKPSRRAAIELLMV 95
           AA+ + S+    +K+ C  + E    P +  C+++ H      E   K  RR   ++++ 
Sbjct: 18  AASHSRSSSSFSSKLMCR-KREQERKPSVQQCMEYSHLTIRSSEKQTKRMRRKRRKVMLY 76

Query: 96  LAGRAPGLRGLR---LECRGEKPLFD 118
           +  RA GL+G +   L+C+   P  D
Sbjct: 77  VMARAGGLKGDKSEALKCQNRLPHLD 102


>gi|30089926 F-box only protein 11 isoform 1 [Homo sapiens]
          Length = 843

 Score = 30.4 bits (67), Expect = 2.7
 Identities = 15/40 (37%), Positives = 23/40 (57%)

Query: 6   EGLPEEVLALIFRHLSLRDRAAAARVCRAWAAAATCSAVW 45
           E LP+EV+  IF +L  +D   AA VC+ ++  A    +W
Sbjct: 73  EKLPDEVVLKIFSYLLEQDLCRAACVCKRFSELANDPILW 112


  Database: hs.faa
    Posted date:  Aug 4, 2009  4:42 PM
  Number of letters in database: 18,247,518
  Number of sequences in database:  37,866
  
Lambda     K      H
   0.324    0.136    0.419 

Gapped
Lambda     K      H
   0.267   0.0410    0.140 


Matrix: BLOSUM62
Gap Penalties: Existence: 11, Extension: 1
Number of Hits to DB: 15,146,191
Number of Sequences: 37866
Number of extensions: 671358
Number of successful extensions: 2494
Number of sequences better than 10.0: 30
Number of HSP's better than 10.0 without gapping: 29
Number of HSP's successfully gapped in prelim test: 22
Number of HSP's that attempted gapping in prelim test: 2435
Number of HSP's gapped (non-prelim): 80
length of query: 374
length of database: 18,247,518
effective HSP length: 104
effective length of query: 270
effective length of database: 14,309,454
effective search space: 3863552580
effective search space used: 3863552580
T: 11
A: 40
X1: 15 ( 7.0 bits)
X2: 38 (14.6 bits)
X3: 64 (24.7 bits)
S1: 40 (21.6 bits)
S2: 63 (28.9 bits)
Search results were obtained with NCBI BLAST and RefSeq entries.