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Search of human proteins with 115430248
BLASTP 2.2.11 [Jun-05-2005]
Reference: Altschul, Stephen F., Thomas L. Madden, Alejandro A. Schaffer,
Jinghui Zhang, Zheng Zhang, Webb Miller, and David J. Lipman (1997),
"Gapped BLAST and PSI-BLAST: a new generation of protein database search
programs", Nucleic Acids Res. 25:3389-3402.
Query= gi|115430248 gp130-like monocyte receptor [Homo sapiens]
(764 letters)
Database: hs.faa
37,866 sequences; 18,247,518 total letters
Searching..................................................done
Score E
Sequences producing significant alignments: (bits) Value
gi|115430248 gp130-like monocyte receptor [Homo sapiens] 1579 0.0
gi|28610147 interleukin 6 signal transducer isoform 1 precursor ... 255 9e-68
gi|27437045 colony stimulating factor 3 receptor isoform d precu... 177 2e-44
gi|24496783 colony stimulating factor 3 receptor isoform c precu... 177 2e-44
gi|4503081 colony stimulating factor 3 receptor isoform a precur... 177 2e-44
gi|27437042 colony stimulating factor 3 receptor isoform b precu... 149 9e-36
gi|4504993 leukemia inhibitory factor receptor precursor [Homo s... 135 1e-31
gi|189083786 leukemia inhibitory factor receptor precursor [Homo... 135 1e-31
gi|4504643 interleukin 12 receptor, beta 2 precursor [Homo sapiens] 122 2e-27
gi|4557040 oncostatin M receptor [Homo sapiens] 111 3e-24
gi|28610149 interleukin 6 signal transducer isoform 2 precursor ... 99 2e-20
gi|4758062 cytokine receptor-like factor 1 [Homo sapiens] 86 2e-16
gi|51093381 leptin receptor isoform 3 [Homo sapiens] 67 5e-11
gi|51093379 leptin receptor isoform 2 [Homo sapiens] 67 5e-11
gi|40254464 leptin receptor isoform 1 [Homo sapiens] 67 5e-11
gi|4759328 class I cytokine receptor [Homo sapiens] 64 7e-10
gi|21359935 Down syndrome cell adhesion molecule like 1 [Homo sa... 64 7e-10
gi|24430212 interleukin 23 receptor precursor [Homo sapiens] 58 4e-08
gi|4506107 prolactin receptor [Homo sapiens] 57 5e-08
gi|109633041 protein tyrosine phosphatase, receptor type, F isof... 57 5e-08
gi|109633039 protein tyrosine phosphatase, receptor type, F isof... 57 5e-08
gi|22212918 ciliary neurotrophic factor receptor preproprotein [... 55 3e-07
gi|4502931 ciliary neurotrophic factor receptor preproprotein [H... 55 3e-07
gi|222537743 protein tyrosine phosphatase, receptor type, Q [Hom... 54 4e-07
gi|93141047 collagen, type XII, alpha 1 long isoform precursor [... 53 9e-07
gi|75709184 contactin 3 [Homo sapiens] 53 1e-06
gi|4504647 interleukin 13 receptor, alpha 1 precursor [Homo sapi... 49 1e-05
gi|55743096 collagen, type XIV, alpha 1 [Homo sapiens] 48 3e-05
gi|218505839 interleukin 11 receptor, alpha isoform 1 precursor ... 48 4e-05
gi|22212922 interleukin 11 receptor, alpha isoform 2 precursor [... 48 4e-05
>gi|115430248 gp130-like monocyte receptor [Homo sapiens]
Length = 764
Score = 1579 bits (4089), Expect = 0.0
Identities = 764/764 (100%), Positives = 764/764 (100%)
Query: 1 MCIRQLKFFTTACVCECPQNILSPQPSCVNLGMMWTWALWMLPSLCKFSLAALPAKPENI 60
MCIRQLKFFTTACVCECPQNILSPQPSCVNLGMMWTWALWMLPSLCKFSLAALPAKPENI
Sbjct: 1 MCIRQLKFFTTACVCECPQNILSPQPSCVNLGMMWTWALWMLPSLCKFSLAALPAKPENI 60
Query: 61 SCVYYYRKNLTCTWSPGKETSYTQYTVKRTYAFGEKHDNCTTNSSTSENRASCSFFLPRI 120
SCVYYYRKNLTCTWSPGKETSYTQYTVKRTYAFGEKHDNCTTNSSTSENRASCSFFLPRI
Sbjct: 61 SCVYYYRKNLTCTWSPGKETSYTQYTVKRTYAFGEKHDNCTTNSSTSENRASCSFFLPRI 120
Query: 121 TIPDNYTIEVEAENGDGVIKSHMTYWRLENIAKTEPPKIFRVKPVLGIKRMIQIEWIKPE 180
TIPDNYTIEVEAENGDGVIKSHMTYWRLENIAKTEPPKIFRVKPVLGIKRMIQIEWIKPE
Sbjct: 121 TIPDNYTIEVEAENGDGVIKSHMTYWRLENIAKTEPPKIFRVKPVLGIKRMIQIEWIKPE 180
Query: 181 LAPVSSDLKYTLRFRTVNSTSWMEVNFAKNRKDKNQTYNLTGLQPFTEYVIALRCAVKES 240
LAPVSSDLKYTLRFRTVNSTSWMEVNFAKNRKDKNQTYNLTGLQPFTEYVIALRCAVKES
Sbjct: 181 LAPVSSDLKYTLRFRTVNSTSWMEVNFAKNRKDKNQTYNLTGLQPFTEYVIALRCAVKES 240
Query: 241 KFWSDWSQEKMGMTEEEAPCGLELWRVLKPAEADGRRPVRLLWKKARGAPVLEKTLGYNI 300
KFWSDWSQEKMGMTEEEAPCGLELWRVLKPAEADGRRPVRLLWKKARGAPVLEKTLGYNI
Sbjct: 241 KFWSDWSQEKMGMTEEEAPCGLELWRVLKPAEADGRRPVRLLWKKARGAPVLEKTLGYNI 300
Query: 301 WYYPESNTNLTETMNTTNQQLELHLGGESFWVSMISYNSLGKSPVATLRIPAIQEKSFQC 360
WYYPESNTNLTETMNTTNQQLELHLGGESFWVSMISYNSLGKSPVATLRIPAIQEKSFQC
Sbjct: 301 WYYPESNTNLTETMNTTNQQLELHLGGESFWVSMISYNSLGKSPVATLRIPAIQEKSFQC 360
Query: 361 IEVMQACVAEDQLVVKWQSSALDVNTWMIEWFPDVDSEPTTLSWESVSQATNWTIQQDKL 420
IEVMQACVAEDQLVVKWQSSALDVNTWMIEWFPDVDSEPTTLSWESVSQATNWTIQQDKL
Sbjct: 361 IEVMQACVAEDQLVVKWQSSALDVNTWMIEWFPDVDSEPTTLSWESVSQATNWTIQQDKL 420
Query: 421 KPFWCYNISVYPMLHDKVGEPYSIQAYAKEGVPSEGPETKVENIGVKTVTITWKEIPKSE 480
KPFWCYNISVYPMLHDKVGEPYSIQAYAKEGVPSEGPETKVENIGVKTVTITWKEIPKSE
Sbjct: 421 KPFWCYNISVYPMLHDKVGEPYSIQAYAKEGVPSEGPETKVENIGVKTVTITWKEIPKSE 480
Query: 481 RKGIICNYTIFYQAEGGKGFSKTVNSSILQYGLESLKRKTSYIVQVMASTSAGGTNGTSI 540
RKGIICNYTIFYQAEGGKGFSKTVNSSILQYGLESLKRKTSYIVQVMASTSAGGTNGTSI
Sbjct: 481 RKGIICNYTIFYQAEGGKGFSKTVNSSILQYGLESLKRKTSYIVQVMASTSAGGTNGTSI 540
Query: 541 NFKTLSFSVFEIILITSLIGGGLLILIILTVAYGLKKPNKLTHLCWPTVPNPAESSIATW 600
NFKTLSFSVFEIILITSLIGGGLLILIILTVAYGLKKPNKLTHLCWPTVPNPAESSIATW
Sbjct: 541 NFKTLSFSVFEIILITSLIGGGLLILIILTVAYGLKKPNKLTHLCWPTVPNPAESSIATW 600
Query: 601 HGDDFKDKLNLKESDDSVNTEDRILKPCSTPSDKLVIDKLVVNFGNVLQEIFTDEARTGQ 660
HGDDFKDKLNLKESDDSVNTEDRILKPCSTPSDKLVIDKLVVNFGNVLQEIFTDEARTGQ
Sbjct: 601 HGDDFKDKLNLKESDDSVNTEDRILKPCSTPSDKLVIDKLVVNFGNVLQEIFTDEARTGQ 660
Query: 661 ENNLGGEKNGYVTCPFRPDCPLGKSFEELPVSPEIPPRKSQYLRSRMPEGTRPEAKEQLL 720
ENNLGGEKNGYVTCPFRPDCPLGKSFEELPVSPEIPPRKSQYLRSRMPEGTRPEAKEQLL
Sbjct: 661 ENNLGGEKNGYVTCPFRPDCPLGKSFEELPVSPEIPPRKSQYLRSRMPEGTRPEAKEQLL 720
Query: 721 FSGQSLVPDHLCEEGAPNPYLKNSVTAREFLVSEKLPEHTKGEV 764
FSGQSLVPDHLCEEGAPNPYLKNSVTAREFLVSEKLPEHTKGEV
Sbjct: 721 FSGQSLVPDHLCEEGAPNPYLKNSVTAREFLVSEKLPEHTKGEV 764
>gi|28610147 interleukin 6 signal transducer isoform 1 precursor
[Homo sapiens]
Length = 918
Score = 255 bits (652), Expect = 9e-68
Identities = 163/551 (29%), Positives = 268/551 (48%), Gaps = 14/551 (2%)
Query: 54 PAKPENISCVYYYRKNLTCTWSPGKETSY-TQYTVKRTYAFGEKHDNCTTNSSTSENRAS 112
P KP+N+SC+ K + C W G+ET T +T+K +A K +C T S
Sbjct: 126 PEKPKNLSCIVNEGKKMRCEWDGGRETHLETNFTLKSEWAT-HKFADCKAKRDTP---TS 181
Query: 113 CSFFLPRITIPDNYTIEVEAENGDGVIKS-HMTYWRLENIAKTEPPKIFRVKPVLGIKRM 171
C+ + N + VEAEN G + S H+ + + + K PP V + +
Sbjct: 182 CTVDYSTVYFV-NIEVWVEAENALGKVTSDHINFDPVYKV-KPNPPHNLSVINSEELSSI 239
Query: 172 IQIEWIKPELAPVSSDLKYTLRFRTVNSTSWMEVNFAKNRKDKNQTYNLTGLQPFTEYVI 231
+++ W P + V LKY +++RT ++++W ++ ++ ++ + L+PFTEYV
Sbjct: 240 LKLTWTNPSIKSVII-LKYNIQYRTKDASTWSQIP-PEDTASTRSSFTVQDLKPFTEYVF 297
Query: 232 ALRCAVKESK-FWSDWSQEKMGMTEEEAPCGL-ELWRVLKPAEADGRRPVRLLWKKARGA 289
+RC ++ K +WSDWS+E G+T E+ P W + P+ G R V+L+WK
Sbjct: 298 RIRCMKEDGKGYWSDWSEEASGITYEDRPSKAPSFWYKIDPSHTQGYRTVQLVWKTLPPF 357
Query: 290 PVLEKTLGYNIWYYPESNTNLTETMNTTNQQLELHLGGESFWVSMISYNSLGKSPVATLR 349
K L Y + + T+N T +L ++L + + ++ N +GKS A L
Sbjct: 358 EANGKILDYEVTLTRWKSHLQNYTVNAT--KLTVNLTNDRYLATLTVRNLVGKSDAAVLT 415
Query: 350 IPAIQEKSFQCIEVMQACVAEDQLVVKWQSSALDVNTWMIEWFPDVDSEPTTLSWESVSQ 409
IPA ++ + ++A ++ L V+W + V +++EW D P W+
Sbjct: 416 IPACDFQATHPVMDLKAFPKDNMLWVEWTTPRESVKKYILEWCVLSDKAPCITDWQQEDG 475
Query: 410 ATNWTIQQDKLKPFWCYNISVYPMLHDKVGEPYSIQAYAKEGVPSEGPETKVENIGVKTV 469
+ T + L CY I+V P+ D G P SI+AY K+ PS+GP + + +G
Sbjct: 476 TVHRTYLRGNLAESKCYLITVTPVYADGPGSPESIKAYLKQAPPSKGPTVRTKKVGKNEA 535
Query: 470 TITWKEIPKSERKGIICNYTIFYQAEGGKGFSKTVNSSILQYGLESLKRKTSYIVQVMAS 529
+ W ++P + G I NYTIFY+ G + V+SS +Y L SL T Y+V++ A
Sbjct: 536 VLEWDQLPVDVQNGFIRNYTIFYRTIIGNETAVNVDSSHTEYTLSSLTSDTLYMVRMAAY 595
Query: 530 TSAGGTNGTSINFKTLSFSVFEIILITSLIGGGLLILIILTVAYGLKKPNKLTHLCWPTV 589
T GG +G F T F+ EI I + L+ +L V + K + + WP V
Sbjct: 596 TDEGGKDGPEFTFTTPKFAQGEIEAIVVPVCLAFLLTTLLGVLFCFNKRDLIKKHIWPNV 655
Query: 590 PNPAESSIATW 600
P+P++S IA W
Sbjct: 656 PDPSKSHIAQW 666
>gi|27437045 colony stimulating factor 3 receptor isoform d
precursor [Homo sapiens]
Length = 783
Score = 177 bits (450), Expect = 2e-44
Identities = 160/571 (28%), Positives = 246/571 (43%), Gaps = 44/571 (7%)
Query: 54 PAKPENISCVYYYR-KNLTCTWSPGKETSY-TQYTVKRTYAFGEKHDNCTTNSST----- 106
PA P N+SC+ +L C W PG ET T +T+K + G NC T +
Sbjct: 123 PAIPHNLSCLMNLTTSSLICQWEPGPETHLPTSFTLKSFKSRG----NCQTQGDSILDCV 178
Query: 107 -SENRASCSFFLPRITIPDNYTIEVEAENGDGVIKSHMTYWRLENIAKTEPPKIFRVKPV 165
+ ++ C + + N I V+AEN G S ++ K EPP + + P
Sbjct: 179 PKDGQSHCCIPRKHLLLYQNMGIWVQAENALGTSMSPQLCLDPMDVVKLEPPMLRTMDPS 238
Query: 166 LGIKR----MIQIEWIKPELAPVSSDLKYTLRFRTVNS-TSWMEVNFAKNRKDKNQTYNL 220
+Q+ W +P + + K LR + SW V + Y L
Sbjct: 239 PEAAPPQAGCLQLCW-EPWQPGLHINQKCELRHKPQRGEASWALVGPLPLEALQ---YEL 294
Query: 221 TGLQPFTEYVIALRCAVKESK-FWSDWSQEKMGMTEEEAPC-GLELW---RVLKPAEADG 275
GL P T Y + +RC WSDWS T E AP L+ W R L P
Sbjct: 295 CGLLPATAYTLQIRCIRWPLPGHWSDWSPSLELRTTERAPTVRLDTWWRQRQLDP----- 349
Query: 276 RRPVRLLWKKARGAPVLEKTLGYNIWYYPESNTN-LTETMNTTNQQLELHLGGESFWVSM 334
R V+L WK + GY + + P + NTT HL E+ V++
Sbjct: 350 -RTVQLFWKPVPLEEDSGRIQGYVVSWRPSGQAGAILPLCNTTELSCTFHLPSEAQEVAL 408
Query: 335 ISYNSLGKSPVATLRIPAIQEKSFQCIEVMQACVAED--QLVVKWQSSALDVNTWMIEWF 392
++YNS G S P + +S +A D L V W+ ++IEW
Sbjct: 409 VAYNSAGTSRPT----PVVFSESRGPALTRLHAMARDPHSLWVGWEPPNPWPQGYVIEWG 464
Query: 393 ---PDVDSEPTTLSWESVSQATNWTIQQDKLKPFWCYNISVYPMLHDKVGEPYSIQAYAK 449
P + T E +AT + ++++ ++PF Y I V P+ D +G + AY++
Sbjct: 465 LGPPSASNSNKTWRMEQNGRATGFLLKEN-IRPFQLYEIIVTPLYQDTMGPSQHVYAYSQ 523
Query: 450 EGVPSEGPETKVENIGVKTVTITWKEIPKSERKGIICNYTIFYQAEGGKGFSKTVNSSIL 509
E PS PE +++IG + W P K + +YTIF+ + FS +N+S
Sbjct: 524 EMAPSHAPELHLKHIGKTWAQLEWVPEPPELGKSPLTHYTIFWTNAQNQSFSAILNASSR 583
Query: 510 QYGLESLKRKTSYIVQVMASTSAGGTNGTSINFKTLSFSVFEIILITSLIGGGLLILIIL 569
+ L L+ + Y + +MA++ AG TN T + TL+ E+ +I L G LL+ +
Sbjct: 584 GFVLHGLEPASLYHIHLMAASQAGATNSTVLTLMTLTPEGSELHIILGLFGLLLLLTCLC 643
Query: 570 TVAYGLKKPNKLTHLCWPTVPNPAESSIATW 600
A+ PN+ L WP+VP+PA SS+ +W
Sbjct: 644 GTAWLCCSPNRKNPL-WPSVPDPAHSSLGSW 673
>gi|24496783 colony stimulating factor 3 receptor isoform c
precursor [Homo sapiens]
Length = 863
Score = 177 bits (450), Expect = 2e-44
Identities = 160/571 (28%), Positives = 246/571 (43%), Gaps = 44/571 (7%)
Query: 54 PAKPENISCVYYYR-KNLTCTWSPGKETSY-TQYTVKRTYAFGEKHDNCTTNSST----- 106
PA P N+SC+ +L C W PG ET T +T+K + G NC T +
Sbjct: 123 PAIPHNLSCLMNLTTSSLICQWEPGPETHLPTSFTLKSFKSRG----NCQTQGDSILDCV 178
Query: 107 -SENRASCSFFLPRITIPDNYTIEVEAENGDGVIKSHMTYWRLENIAKTEPPKIFRVKPV 165
+ ++ C + + N I V+AEN G S ++ K EPP + + P
Sbjct: 179 PKDGQSHCCIPRKHLLLYQNMGIWVQAENALGTSMSPQLCLDPMDVVKLEPPMLRTMDPS 238
Query: 166 LGIKR----MIQIEWIKPELAPVSSDLKYTLRFRTVNS-TSWMEVNFAKNRKDKNQTYNL 220
+Q+ W +P + + K LR + SW V + Y L
Sbjct: 239 PEAAPPQAGCLQLCW-EPWQPGLHINQKCELRHKPQRGEASWALVGPLPLEALQ---YEL 294
Query: 221 TGLQPFTEYVIALRCAVKESK-FWSDWSQEKMGMTEEEAPC-GLELW---RVLKPAEADG 275
GL P T Y + +RC WSDWS T E AP L+ W R L P
Sbjct: 295 CGLLPATAYTLQIRCIRWPLPGHWSDWSPSLELRTTERAPTVRLDTWWRQRQLDP----- 349
Query: 276 RRPVRLLWKKARGAPVLEKTLGYNIWYYPESNTN-LTETMNTTNQQLELHLGGESFWVSM 334
R V+L WK + GY + + P + NTT HL E+ V++
Sbjct: 350 -RTVQLFWKPVPLEEDSGRIQGYVVSWRPSGQAGAILPLCNTTELSCTFHLPSEAQEVAL 408
Query: 335 ISYNSLGKSPVATLRIPAIQEKSFQCIEVMQACVAED--QLVVKWQSSALDVNTWMIEWF 392
++YNS G S P + +S +A D L V W+ ++IEW
Sbjct: 409 VAYNSAGTSRPT----PVVFSESRGPALTRLHAMARDPHSLWVGWEPPNPWPQGYVIEWG 464
Query: 393 ---PDVDSEPTTLSWESVSQATNWTIQQDKLKPFWCYNISVYPMLHDKVGEPYSIQAYAK 449
P + T E +AT + ++++ ++PF Y I V P+ D +G + AY++
Sbjct: 465 LGPPSASNSNKTWRMEQNGRATGFLLKEN-IRPFQLYEIIVTPLYQDTMGPSQHVYAYSQ 523
Query: 450 EGVPSEGPETKVENIGVKTVTITWKEIPKSERKGIICNYTIFYQAEGGKGFSKTVNSSIL 509
E PS PE +++IG + W P K + +YTIF+ + FS +N+S
Sbjct: 524 EMAPSHAPELHLKHIGKTWAQLEWVPEPPELGKSPLTHYTIFWTNAQNQSFSAILNASSR 583
Query: 510 QYGLESLKRKTSYIVQVMASTSAGGTNGTSINFKTLSFSVFEIILITSLIGGGLLILIIL 569
+ L L+ + Y + +MA++ AG TN T + TL+ E+ +I L G LL+ +
Sbjct: 584 GFVLHGLEPASLYHIHLMAASQAGATNSTVLTLMTLTPEGSELHIILGLFGLLLLLTCLC 643
Query: 570 TVAYGLKKPNKLTHLCWPTVPNPAESSIATW 600
A+ PN+ L WP+VP+PA SS+ +W
Sbjct: 644 GTAWLCCSPNRKNPL-WPSVPDPAHSSLGSW 673
>gi|4503081 colony stimulating factor 3 receptor isoform a precursor
[Homo sapiens]
Length = 836
Score = 177 bits (450), Expect = 2e-44
Identities = 160/571 (28%), Positives = 246/571 (43%), Gaps = 44/571 (7%)
Query: 54 PAKPENISCVYYYR-KNLTCTWSPGKETSY-TQYTVKRTYAFGEKHDNCTTNSST----- 106
PA P N+SC+ +L C W PG ET T +T+K + G NC T +
Sbjct: 123 PAIPHNLSCLMNLTTSSLICQWEPGPETHLPTSFTLKSFKSRG----NCQTQGDSILDCV 178
Query: 107 -SENRASCSFFLPRITIPDNYTIEVEAENGDGVIKSHMTYWRLENIAKTEPPKIFRVKPV 165
+ ++ C + + N I V+AEN G S ++ K EPP + + P
Sbjct: 179 PKDGQSHCCIPRKHLLLYQNMGIWVQAENALGTSMSPQLCLDPMDVVKLEPPMLRTMDPS 238
Query: 166 LGIKR----MIQIEWIKPELAPVSSDLKYTLRFRTVNS-TSWMEVNFAKNRKDKNQTYNL 220
+Q+ W +P + + K LR + SW V + Y L
Sbjct: 239 PEAAPPQAGCLQLCW-EPWQPGLHINQKCELRHKPQRGEASWALVGPLPLEALQ---YEL 294
Query: 221 TGLQPFTEYVIALRCAVKESK-FWSDWSQEKMGMTEEEAPC-GLELW---RVLKPAEADG 275
GL P T Y + +RC WSDWS T E AP L+ W R L P
Sbjct: 295 CGLLPATAYTLQIRCIRWPLPGHWSDWSPSLELRTTERAPTVRLDTWWRQRQLDP----- 349
Query: 276 RRPVRLLWKKARGAPVLEKTLGYNIWYYPESNTN-LTETMNTTNQQLELHLGGESFWVSM 334
R V+L WK + GY + + P + NTT HL E+ V++
Sbjct: 350 -RTVQLFWKPVPLEEDSGRIQGYVVSWRPSGQAGAILPLCNTTELSCTFHLPSEAQEVAL 408
Query: 335 ISYNSLGKSPVATLRIPAIQEKSFQCIEVMQACVAED--QLVVKWQSSALDVNTWMIEWF 392
++YNS G S P + +S +A D L V W+ ++IEW
Sbjct: 409 VAYNSAGTSRPT----PVVFSESRGPALTRLHAMARDPHSLWVGWEPPNPWPQGYVIEWG 464
Query: 393 ---PDVDSEPTTLSWESVSQATNWTIQQDKLKPFWCYNISVYPMLHDKVGEPYSIQAYAK 449
P + T E +AT + ++++ ++PF Y I V P+ D +G + AY++
Sbjct: 465 LGPPSASNSNKTWRMEQNGRATGFLLKEN-IRPFQLYEIIVTPLYQDTMGPSQHVYAYSQ 523
Query: 450 EGVPSEGPETKVENIGVKTVTITWKEIPKSERKGIICNYTIFYQAEGGKGFSKTVNSSIL 509
E PS PE +++IG + W P K + +YTIF+ + FS +N+S
Sbjct: 524 EMAPSHAPELHLKHIGKTWAQLEWVPEPPELGKSPLTHYTIFWTNAQNQSFSAILNASSR 583
Query: 510 QYGLESLKRKTSYIVQVMASTSAGGTNGTSINFKTLSFSVFEIILITSLIGGGLLILIIL 569
+ L L+ + Y + +MA++ AG TN T + TL+ E+ +I L G LL+ +
Sbjct: 584 GFVLHGLEPASLYHIHLMAASQAGATNSTVLTLMTLTPEGSELHIILGLFGLLLLLTCLC 643
Query: 570 TVAYGLKKPNKLTHLCWPTVPNPAESSIATW 600
A+ PN+ L WP+VP+PA SS+ +W
Sbjct: 644 GTAWLCCSPNRKNPL-WPSVPDPAHSSLGSW 673
>gi|27437042 colony stimulating factor 3 receptor isoform b
precursor [Homo sapiens]
Length = 769
Score = 149 bits (376), Expect = 9e-36
Identities = 141/517 (27%), Positives = 217/517 (41%), Gaps = 43/517 (8%)
Query: 54 PAKPENISCVYYYR-KNLTCTWSPGKETSY-TQYTVKRTYAFGEKHDNCTTNSST----- 106
PA P N+SC+ +L C W PG ET T +T+K + G NC T +
Sbjct: 123 PAIPHNLSCLMNLTTSSLICQWEPGPETHLPTSFTLKSFKSRG----NCQTQGDSILDCV 178
Query: 107 -SENRASCSFFLPRITIPDNYTIEVEAENGDGVIKSHMTYWRLENIAKTEPPKIFRVKPV 165
+ ++ C + + N I V+AEN G S ++ K EPP + + P
Sbjct: 179 PKDGQSHCCIPRKHLLLYQNMGIWVQAENALGTSMSPQLCLDPMDVVKLEPPMLRTMDPS 238
Query: 166 LGIKR----MIQIEWIKPELAPVSSDLKYTLRFRTVNS-TSWMEVNFAKNRKDKNQTYNL 220
+Q+ W +P + + K LR + SW V + Y L
Sbjct: 239 PEAAPPQAGCLQLCW-EPWQPGLHINQKCELRHKPQRGEASWALVGPLPLEALQ---YEL 294
Query: 221 TGLQPFTEYVIALRCAVKESK-FWSDWSQEKMGMTEEEAPC-GLELW---RVLKPAEADG 275
GL P T Y + +RC WSDWS T E AP L+ W R L P
Sbjct: 295 CGLLPATAYTLQIRCIRWPLPGHWSDWSPSLELRTTERAPTVRLDTWWRQRQLDP----- 349
Query: 276 RRPVRLLWKKARGAPVLEKTLGYNIWYYPESNTN-LTETMNTTNQQLELHLGGESFWVSM 334
R V+L WK + GY + + P + NTT HL E+ V++
Sbjct: 350 -RTVQLFWKPVPLEEDSGRIQGYVVSWRPSGQAGAILPLCNTTELSCTFHLPSEAQEVAL 408
Query: 335 ISYNSLGKSPVATLRIPAIQEKSFQCIEVMQACVAED--QLVVKWQSSALDVNTWMIEWF 392
++YNS G S P + +S +A D L V W+ ++IEW
Sbjct: 409 VAYNSAGTSRPT----PVVFSESRGPALTRLHAMARDPHSLWVGWEPPNPWPQGYVIEWG 464
Query: 393 ---PDVDSEPTTLSWESVSQATNWTIQQDKLKPFWCYNISVYPMLHDKVGEPYSIQAYAK 449
P + T E +AT + ++++ ++PF Y I V P+ D +G + AY++
Sbjct: 465 LGPPSASNSNKTWRMEQNGRATGFLLKEN-IRPFQLYEIIVTPLYQDTMGPSQHVYAYSQ 523
Query: 450 EGVPSEGPETKVENIGVKTVTITWKEIPKSERKGIICNYTIFYQAEGGKGFSKTVNSSIL 509
E PS PE +++IG + W P K + +YTIF+ + FS +N+S
Sbjct: 524 EMAPSHAPELHLKHIGKTWAQLEWVPEPPELGKSPLTHYTIFWTNAQNQSFSAILNASSR 583
Query: 510 QYGLESLKRKTSYIVQVMASTSAGGTNGTSINFKTLS 546
+ L L+ + Y + +MA++ AG TN T + TL+
Sbjct: 584 GFVLHGLEPASLYHIHLMAASQAGATNSTVLTLMTLT 620
>gi|4504993 leukemia inhibitory factor receptor precursor [Homo
sapiens]
Length = 1097
Score = 135 bits (340), Expect = 1e-31
Identities = 130/569 (22%), Positives = 235/569 (41%), Gaps = 55/569 (9%)
Query: 54 PAKPENISCVYYYRKNLTCTWSPGKETSY-----TQYTVKRTYAFGEKHDNCTTNSSTSE 108
P P+ ++C + K + C+W+PG+ T+ T YT+ +++ G+ + T+E
Sbjct: 333 PDTPQQLNCETHDLKEIICSWNPGRVTALVGPRATSYTLVESFS-GKYVRLKRAEAPTNE 391
Query: 109 NRASCSFFLPRITIPDNYTIEVEAENGDGVIKSHMTYWRLENIAKTEPPKIFRVKPVLGI 168
+ LP I Y + A N G +S + E + P F+VK +
Sbjct: 392 SYQLLFQMLPNQEI---YNFTLNAHNPLGRSQSTILVNITEKVYPHTPTS-FKVKDINST 447
Query: 169 KRMIQIEWIKPELAPVSSDLKYTLRFRTVNSTSWMEVNFAKNRKDKNQTY--NLTGLQPF 226
+++ W L + + + S S E + +N +Y L L P+
Sbjct: 448 A--VKLSW---HLPGNFAKINFLCEIEIKKSNSVQEQRNVTIKGVENSSYLVALDKLNPY 502
Query: 227 TEYVIALRCAVKESKFWSDWSQEKMGMTEEEAPC-GLELWRVLKPAEADGRRPVRLLWKK 285
T Y +RC+ + WS WS +K +T E +P G + WR +DG+ + + WK
Sbjct: 503 TLYTFRIRCSTETFWKWSKWSNKKQHLTTEASPSKGPDTWR---EWSSDGKNLI-IYWKP 558
Query: 286 ARGAPVLEKTLGYNIWYYPESNTNLTETMNTTNQQLELHLGGESFWVSMISYNSLGKSP- 344
K L YN+ + T + + E+ L + +S+++ NS+G SP
Sbjct: 559 LPINEANGKILSYNVSCSSDEETQSLSEIPDPQHKAEIRLDKNDYIISVVAKNSVGSSPP 618
Query: 345 --VATLRIPAIQEKSFQCIEVMQACVAEDQLVVKWQSSALDVNTWMIEWFPDVDSEPTTL 402
+A++ IP K Q + + + +++ W ++I+W SEP +
Sbjct: 619 SKIASMEIPNDDLKIEQVVGMGKG------ILLTWHYDPNMTCDYVIKWCNSSRSEPCLM 672
Query: 403 SWESV-SQATNWTIQQDKLKPFWCYNISVYPMLHDKVGEPYSIQAYAKEGVPSEGPETKV 461
W V S +T I+ D+ +P YN +Y + S+ Y +E P P V
Sbjct: 673 DWRKVPSNSTETVIESDEFRPGIRYNFFLYGCRNQGYQLLRSMIGYIEELAPIVAPNFTV 732
Query: 462 ENIGVKTVTITWKEIPKSERKGIICNYTIFYQAEGGKGFSKTVNSSILQYG--------- 512
E+ ++ + W++IP E +G + Y ++ GKG T +L+ G
Sbjct: 733 EDTSADSILVKWEDIPVEELRGFLRGYLFYF----GKGERDTSKMRVLESGRSDIKVKNI 788
Query: 513 ---------LESLKRKTSYIVQVMASTSAGGTNGTSINFKTLSFSVFEIILITSLIGGGL 563
+ L+ KTSY + + A T G S+ T SV II I + +
Sbjct: 789 TDISQKTLRIADLQGKTSYHLVLRAYTDGGVGPEKSMYVVTKENSVGLIIAILIPVAVAV 848
Query: 564 LILIILTVAYGLKKPNKLTHLCWPTVPNP 592
++ ++ ++ +K + +P +PNP
Sbjct: 849 IVGVVTSILC-YRKREWIKETFYPDIPNP 876
>gi|189083786 leukemia inhibitory factor receptor precursor [Homo
sapiens]
Length = 1097
Score = 135 bits (340), Expect = 1e-31
Identities = 130/569 (22%), Positives = 235/569 (41%), Gaps = 55/569 (9%)
Query: 54 PAKPENISCVYYYRKNLTCTWSPGKETSY-----TQYTVKRTYAFGEKHDNCTTNSSTSE 108
P P+ ++C + K + C+W+PG+ T+ T YT+ +++ G+ + T+E
Sbjct: 333 PDTPQQLNCETHDLKEIICSWNPGRVTALVGPRATSYTLVESFS-GKYVRLKRAEAPTNE 391
Query: 109 NRASCSFFLPRITIPDNYTIEVEAENGDGVIKSHMTYWRLENIAKTEPPKIFRVKPVLGI 168
+ LP I Y + A N G +S + E + P F+VK +
Sbjct: 392 SYQLLFQMLPNQEI---YNFTLNAHNPLGRSQSTILVNITEKVYPHTPTS-FKVKDINST 447
Query: 169 KRMIQIEWIKPELAPVSSDLKYTLRFRTVNSTSWMEVNFAKNRKDKNQTY--NLTGLQPF 226
+++ W L + + + S S E + +N +Y L L P+
Sbjct: 448 A--VKLSW---HLPGNFAKINFLCEIEIKKSNSVQEQRNVTIKGVENSSYLVALDKLNPY 502
Query: 227 TEYVIALRCAVKESKFWSDWSQEKMGMTEEEAPC-GLELWRVLKPAEADGRRPVRLLWKK 285
T Y +RC+ + WS WS +K +T E +P G + WR +DG+ + + WK
Sbjct: 503 TLYTFRIRCSTETFWKWSKWSNKKQHLTTEASPSKGPDTWR---EWSSDGKNLI-IYWKP 558
Query: 286 ARGAPVLEKTLGYNIWYYPESNTNLTETMNTTNQQLELHLGGESFWVSMISYNSLGKSP- 344
K L YN+ + T + + E+ L + +S+++ NS+G SP
Sbjct: 559 LPINEANGKILSYNVSCSSDEETQSLSEIPDPQHKAEIRLDKNDYIISVVAKNSVGSSPP 618
Query: 345 --VATLRIPAIQEKSFQCIEVMQACVAEDQLVVKWQSSALDVNTWMIEWFPDVDSEPTTL 402
+A++ IP K Q + + + +++ W ++I+W SEP +
Sbjct: 619 SKIASMEIPNDDLKIEQVVGMGKG------ILLTWHYDPNMTCDYVIKWCNSSRSEPCLM 672
Query: 403 SWESV-SQATNWTIQQDKLKPFWCYNISVYPMLHDKVGEPYSIQAYAKEGVPSEGPETKV 461
W V S +T I+ D+ +P YN +Y + S+ Y +E P P V
Sbjct: 673 DWRKVPSNSTETVIESDEFRPGIRYNFFLYGCRNQGYQLLRSMIGYIEELAPIVAPNFTV 732
Query: 462 ENIGVKTVTITWKEIPKSERKGIICNYTIFYQAEGGKGFSKTVNSSILQYG--------- 512
E+ ++ + W++IP E +G + Y ++ GKG T +L+ G
Sbjct: 733 EDTSADSILVKWEDIPVEELRGFLRGYLFYF----GKGERDTSKMRVLESGRSDIKVKNI 788
Query: 513 ---------LESLKRKTSYIVQVMASTSAGGTNGTSINFKTLSFSVFEIILITSLIGGGL 563
+ L+ KTSY + + A T G S+ T SV II I + +
Sbjct: 789 TDISQKTLRIADLQGKTSYHLVLRAYTDGGVGPEKSMYVVTKENSVGLIIAILIPVAVAV 848
Query: 564 LILIILTVAYGLKKPNKLTHLCWPTVPNP 592
++ ++ ++ +K + +P +PNP
Sbjct: 849 IVGVVTSILC-YRKREWIKETFYPDIPNP 876
>gi|4504643 interleukin 12 receptor, beta 2 precursor [Homo sapiens]
Length = 862
Score = 122 bits (305), Expect = 2e-27
Identities = 150/624 (24%), Positives = 253/624 (40%), Gaps = 72/624 (11%)
Query: 54 PAKPENISCVYYYRKN-LTCTWSPGKETS-YTQYTVKRTYAFGEKHDNCTTNSSTSENRA 111
P +P+N+SC+ + + CTW G++T YT+YT++ + G K N T +
Sbjct: 124 PEQPQNLSCIQKGEQGTVACTWERGRDTHLYTEYTLQLS---GPK--NLTWQKQCKDIYC 178
Query: 112 SCSFFLPRITIPD---NYTIEVEAENGDGVIKSHMTYWRLENIAKTEPPKIFRVKPVLGI 168
F +T N+T +V A N G S + + +I + PP R+K
Sbjct: 179 DYLDFGINLTPESPESNFTAKVTAVNSLGSSSSLPSTFTFLDIVRPLPPWDIRIKFQKAS 238
Query: 169 KRMIQIEWIKPELAPVSSDLKYTLRFRTVNSTSWMEVNFAKNRKDKNQTYNLTGLQPFTE 228
+ W L L LR+R NS W VN K + ++L L+PFTE
Sbjct: 239 VSRCTLYWRDEGLV-----LLNRLRYRPSNSRLWNMVNVTKAKG----RHDLLDLKPFTE 289
Query: 229 YVIALRCAVKESK-FWSDWSQEKMGMTEEEAPCG-LELWRVLKPAEADGRRPVRLLWKKA 286
Y + + K WSDWS+ T EE P G L++W + + + R+ + L WK
Sbjct: 290 YEFQISSKLHLYKGSWSDWSESLRAQTPEEEPTGMLDVWYMKRHIDYS-RQQISLFWKNL 348
Query: 287 RGAPVLEKTLGYNIWYYPESNTNLTETMNTTNQQLELHLGGESFWVSMI----------- 335
+ K L Y + T T + + ++ G + W ++I
Sbjct: 349 SVSEARGKILHYQV----------TLQELTGGKAMTQNITGHTSWTTVIPRTGNWAVAVS 398
Query: 336 SYNSLGKSPVATLRIPAIQEKSFQCIEVMQA-CVAEDQLVVKWQSSALD---VNTWMIEW 391
+ NS G S + I + E + A D ++V WQ D V +++EW
Sbjct: 399 AANSKGSSLPTRINIMNLCEAGLLAPRQVSANSEGMDNILVTWQPPRKDPSAVQEYVVEW 458
Query: 392 ---FPDVDSEPTTLSWESVSQATNWTIQQDKLKPFWCYNISVYPMLHDKVGEPYSIQAYA 448
P D++ L+W + + +K + CY I VY + D+ G SI +
Sbjct: 459 RELHPGGDTQ-VPLNWLRSRPYNVSALISENIKSYICYEIRVYALSGDQ-GGCSSILGNS 516
Query: 449 KEGVPSEGPETKVENIGVKTVTITWKEIPKSERKGIICNYTIFYQAEGGKGFSK----TV 504
K P GP ++ I+W IP E+ G + +Y I+++ +
Sbjct: 517 KHKAPLSGPHINAITEEKGSILISWNSIPVQEQMGCLLHYRIYWKERDSNSQPQLCEIPY 576
Query: 505 NSSILQYGLESLKRKTSYIVQVMASTSAG-GTNGTSINFKTLSFSVFEIILITSLIGGGL 563
S + + SL+ + +Y++ + A T+AG ++G F + + + S+ +
Sbjct: 577 RVSQNSHPINSLQPRVTYVLWMTALTAAGESSHGNEREFCLQGKANWMAFVAPSICIAII 636
Query: 564 LILIILTVAYGLKKPNKLTHL----CWPTVPNPAESSIATWHGDDFKDKLNLKESDDSVN 619
++ I T + K L L C +P+PA S+ A K + E +
Sbjct: 637 MVGIFSTHYFQQKVFVLLAALRPQWCSREIPDPANSTCA--------KKYPIAEEKTQLP 688
Query: 620 TEDRILKPCSTPSD--KLVIDKLV 641
DR+L TP D LVI +++
Sbjct: 689 L-DRLLIDWPTPEDPEPLVISEVL 711
>gi|4557040 oncostatin M receptor [Homo sapiens]
Length = 979
Score = 111 bits (277), Expect = 3e-24
Identities = 131/580 (22%), Positives = 235/580 (40%), Gaps = 74/580 (12%)
Query: 56 KPENISCVYYYRKNLTCTWSPGKETSY-------TQYTVKRTYAFGEK----HDNCTTNS 104
+P++ SC K L CTW PG +T+ YT+ +++ GEK H N
Sbjct: 239 EPKDFSCETEDFKTLHCTWDPGTDTALGWSKQPSQSYTLFESFS-GEKKLCTHKNWCNWQ 297
Query: 105 STSENRASCSFFLPRITIPDNY----TIEVEAENGDGVIKSHMTYWRLENIAKTEPPKIF 160
T +++ + +F L I +NY ++ + V + EN+ T +
Sbjct: 298 ITQDSQETYNFTL----IAENYLRKRSVNILFNLTHRVYLMNPFSVNFENVNATNAIMTW 353
Query: 161 RVKPVLGIKRMIQIEWIKPELAPVSSDLKYTLRFRTVNSTSWMEVNFAKNRKDKNQTYNL 220
+V + ++ Y + M+ N + N Y L
Sbjct: 354 KVHSI-------------------RNNFTYLCQIELHGEGKMMQYNVSIK---VNGEYFL 391
Query: 221 TGLQPFTEYVIALRCAVKESKFW--SDWSQEKMGMTEEEAPCGLELWRVLKPAEADGRRP 278
+ L+P TEY+ +RCA S FW S+WS + E ++WR++ + G
Sbjct: 392 SELEPATEYMARVRCA-DASHFWKWSEWSGQNFTTLEAAPSEAPDVWRIV--SLEPGNHT 448
Query: 279 VRLLWKKARGAPVLEKTLGYNIWYYPESNTNLTE--TMNTTNQQLELHLGGESFWVSMIS 336
V L WK K L YN+ + +E ++ +L L S+ + +I+
Sbjct: 449 VTLFWKPLSKLHANGKILFYNVVVENLDKPSSSELHSIPAPANSTKLILDRCSYQICVIA 508
Query: 337 YNSLGKSPVATLRIPAIQEKSFQCIEVMQACVAEDQLVVKWQSSALDVNTWMIEWFPDVD 396
NS+G SP + + I A E +E + E + W+ DV ++++W
Sbjct: 509 NNSVGASPASVIVISADPENKE--VEEERIAGTEGGFSLSWKPQPGDVIGYVVDWCDHTQ 566
Query: 397 SEPTTLSWESVSQATNWT-IQQDKLKPFWCYNISVYPMLHDKVGEPYSIQA-YAKEGVPS 454
W++V T T I D +P Y+ +Y + ++ + Y++E PS
Sbjct: 567 DVLGDFQWKNVGPNTTSTVISTDAFRPGVRYDFRIYGLSTKRIACLLEKKTGYSQELAPS 626
Query: 455 EGPETKVENIGVKTVTITWKEIPKSERKGIICNYTIFYQAEGGK---GFSKTV---NSSI 508
+ P V+ + + T++WK+ + G I Y ++ +++ + F K V S
Sbjct: 627 DNPHVLVDTLTSHSFTLSWKDYSTESQPGFIQGYHVYLKSKARQCHPRFEKAVLSDGSEC 686
Query: 509 LQYGL----------ESLKRKTSYIVQVMASTSAGGTNGTSINF-KTLSFSVFEIILITS 557
+Y + ++LK ++ Y + TSAG G S F K + +LI
Sbjct: 687 CKYKIDNPEEKALIVDNLKPESFYEFFITPFTSAG--EGPSATFTKVTTPDEHSSMLIHI 744
Query: 558 LIGGGLLILIILTVAYGLKKPNKLTHLCWPTVPNPAESSI 597
L+ +L+I+ + Y K + C+P +P+P +SSI
Sbjct: 745 LLPMVFCVLLIMVMCY--LKSQWIKETCYPDIPDPYKSSI 782
>gi|28610149 interleukin 6 signal transducer isoform 2 precursor
[Homo sapiens]
Length = 329
Score = 98.6 bits (244), Expect = 2e-20
Identities = 62/207 (29%), Positives = 107/207 (51%), Gaps = 11/207 (5%)
Query: 54 PAKPENISCVYYYRKNLTCTWSPGKETSY-TQYTVKRTYAFGEKHDNCTTNSSTSENRAS 112
P KP+N+SC+ K + C W G+ET T +T+K +A K +C T S
Sbjct: 126 PEKPKNLSCIVNEGKKMRCEWDGGRETHLETNFTLKSEWA-THKFADCKAKRDTP---TS 181
Query: 113 CSFFLPRITIPDNYTIEVEAENGDGVIKS-HMTYWRLENIAKTEPPKIFRVKPVLGIKRM 171
C+ + N + VEAEN G + S H+ + + + K PP V + +
Sbjct: 182 CTVDYSTVYFV-NIEVWVEAENALGKVTSDHINFDPVYKV-KPNPPHNLSVINSEELSSI 239
Query: 172 IQIEWIKPELAPVSSDLKYTLRFRTVNSTSWMEVNFAKNRKDKNQTYNLTGLQPFTEYVI 231
+++ W P + V LKY +++RT ++++W ++ ++ ++ + L+PFTEYV
Sbjct: 240 LKLTWTNPSIKSVII-LKYNIQYRTKDASTWSQIP-PEDTASTRSSFTVQDLKPFTEYVF 297
Query: 232 ALRCAVKESK-FWSDWSQEKMGMTEEE 257
+RC ++ K +WSDWS+E G+T E+
Sbjct: 298 RIRCMKEDGKGYWSDWSEEASGITYED 324
>gi|4758062 cytokine receptor-like factor 1 [Homo sapiens]
Length = 422
Score = 85.5 bits (210), Expect = 2e-16
Identities = 59/212 (27%), Positives = 96/212 (45%), Gaps = 19/212 (8%)
Query: 54 PAKPENISCVYYYRKNLTCTWSPGKETS---YTQYTVKRTYAFGEKHDNCTTNSSTSENR 110
P KP NISC K+LTC W+PG +T Y++K + + + C + +
Sbjct: 135 PEKPVNISCWSKNMKDLTCRWTPGAHGETFLHTNYSLKYKLRWYGQDNTCEEYHTVGPH- 193
Query: 111 ASCSFFLPR-ITIPDNYTIEVEAENGDGVIKSHMTYWRLENIAKTEPPKIFRVKPVLGIK 169
S +P+ + + Y I VEA N G +S + + ++ T+PP V V G++
Sbjct: 194 ---SCHIPKDLALFTPYEIWVEATNRLGSARSDVLTLDILDVVTTDPPPDVHVSRVGGLE 250
Query: 170 RMIQIEWIK-PELAPVSSDLKYTLRFRTVNSTSWMEVNFAKNRKDKNQTYNLTGLQPFTE 228
+ + W+ P L KY +R+R +S W V+ N+ + L GL+P T
Sbjct: 251 DQLSVRWVSPPALKDFLFQAKYQIRYRVEDSVDWKVVDDVSNQ----TSCRLAGLKPGTV 306
Query: 229 YVIALRC------AVKESKFWSDWSQEKMGMT 254
Y + +RC K++ WS+WS T
Sbjct: 307 YFVQVRCNPFGIYGSKKAGIWSEWSHPTAAST 338
>gi|51093381 leptin receptor isoform 3 [Homo sapiens]
Length = 958
Score = 67.4 bits (163), Expect = 5e-11
Identities = 87/419 (20%), Positives = 165/419 (39%), Gaps = 43/419 (10%)
Query: 59 NISC-VYYYRKNLTCTWSPGKETSYTQYTVKRTYAFGEKHDNCTTNSSTSENRASC---- 113
NISC Y +TC WS S + T++ Y + + + C
Sbjct: 433 NISCETDGYLTKMTCRWSTSTIQSLAESTLQLRYHRSSLYCSDIPSIHPISEPKDCYLQS 492
Query: 114 -----SFFLPRITIPDNYTIEVEAENGDGVIKSHMTYWRLENIAKTEPPKIFRVKPVLGI 168
F P I + YT+ + + G + S T +++ K PP + + + I
Sbjct: 493 DGFYECIFQP-IFLLSGYTMWIRINHSLGSLDSPPTCVLPDSVVKPLPPSSVKAEITINI 551
Query: 169 KRMIQIEWIKPELAPVSSDLKYTLRFRTVNSTSWMEVNFAKNRKDKNQTYNLTGLQPFTE 228
+++I W KP ++L++ +R+ ++ + K K+ + + L
Sbjct: 552 G-LLKISWEKPVFP--ENNLQFQIRYGLSGKEVQWKMYEVYDAKSKSVSLPVPDL--CAV 606
Query: 229 YVIALRCAVKESK-FWSDWSQEKMGMTEE-EAPC-GLELWRVLKPAEADGRRPVRLLWKK 285
Y + +RC + +WS+WS + + + P G E WR++ + V LLWK
Sbjct: 607 YAVQVRCKRLDGLGYWSNWSNPAYTVVMDIKVPMRGPEFWRIINGDTMKKEKNVTLLWKP 666
Query: 286 ARGAPVLEKTLGYNIWYYPESNTNLTETMNTTNQQLELHLGGESFWVSMISYNSLGKS-- 343
L Y I ++ N +E + + L ++ V++++ NS+G S
Sbjct: 667 LMKNDSLCSVQRYVINHHTSCNGTWSEDVGNHTKFTFLWTE-QAHTVTVLAINSIGASVA 725
Query: 344 --------PVATLRIPAIQEKSFQCIEVMQACVAEDQLVVKWQSSALDVNT--WMIEWFP 393
P++ + I +S + +CV +V W S D ++IEW
Sbjct: 726 NFNLTFSWPMSKVNIV----QSLSAYPLNSSCV-----IVSWILSPSDYKLMYFIIEW-- 774
Query: 394 DVDSEPTTLSWESVSQATNWTIQQDKLKPFWCYNISVYPMLHDKVGEPYSIQAYAKEGV 452
+E + W +S + D P Y S+YP+ + VG+P I ++ ++ +
Sbjct: 775 KNLNEDGEIKWLRISSSVKKYYIHDHFIPIEKYQFSLYPIFMEGVGKPKIINSFTQDDI 833
Score = 31.6 bits (70), Expect = 2.9
Identities = 45/224 (20%), Positives = 91/224 (40%), Gaps = 20/224 (8%)
Query: 35 WTWALWMLPSLCKFSLAALPAKPENISCVYYYRKNLTCTWSPGKETSYTQYTVKRTYAFG 94
W W+ L K + + + +N+ Y Y+ +L E S V + +F
Sbjct: 127 WNIQCWLKGDL-KLFICYVESLFKNLFRNYNYKVHLLYVLPEVLEDSPL---VPQKGSFQ 182
Query: 95 EKHDNCTTNSSTSENRASCSFFLPRITIPDNYTIEVEAENGDGVIKSHMTYWRLENIAKT 154
H NC+ + C +P + D + ++ +G + +S + + N+ K
Sbjct: 183 MVHCNCSVHEC-----CECLVPVPTAKLNDTLLMCLKITSGGVIFQSPLMSVQPINMVKP 237
Query: 155 EPPKIFRVKPVLGIKRMIQIEWIKPELAPVSSDLKYTLRFRTVNSTSWMEVNFAKNRKDK 214
+PP ++ + ++I W P L P L+Y +++ ++T E + K
Sbjct: 238 DPPLGLHME--ITDDGNLKISWSSPPLVPFP--LQYQVKYSENSTTVIREAD-----KIV 288
Query: 215 NQTYNLT-GLQPFTEYVIALRCAVKESK-FWSDWSQEKMGMTEE 256
+ T L + P + Y + +R + WSDWS ++ T++
Sbjct: 289 SATSLLVDSILPGSSYEVQVRGKRLDGPGIWSDWSTPRVFTTQD 332
>gi|51093379 leptin receptor isoform 2 [Homo sapiens]
Length = 896
Score = 67.4 bits (163), Expect = 5e-11
Identities = 87/419 (20%), Positives = 165/419 (39%), Gaps = 43/419 (10%)
Query: 59 NISC-VYYYRKNLTCTWSPGKETSYTQYTVKRTYAFGEKHDNCTTNSSTSENRASC---- 113
NISC Y +TC WS S + T++ Y + + + C
Sbjct: 433 NISCETDGYLTKMTCRWSTSTIQSLAESTLQLRYHRSSLYCSDIPSIHPISEPKDCYLQS 492
Query: 114 -----SFFLPRITIPDNYTIEVEAENGDGVIKSHMTYWRLENIAKTEPPKIFRVKPVLGI 168
F P I + YT+ + + G + S T +++ K PP + + + I
Sbjct: 493 DGFYECIFQP-IFLLSGYTMWIRINHSLGSLDSPPTCVLPDSVVKPLPPSSVKAEITINI 551
Query: 169 KRMIQIEWIKPELAPVSSDLKYTLRFRTVNSTSWMEVNFAKNRKDKNQTYNLTGLQPFTE 228
+++I W KP ++L++ +R+ ++ + K K+ + + L
Sbjct: 552 G-LLKISWEKPVFP--ENNLQFQIRYGLSGKEVQWKMYEVYDAKSKSVSLPVPDL--CAV 606
Query: 229 YVIALRCAVKESK-FWSDWSQEKMGMTEE-EAPC-GLELWRVLKPAEADGRRPVRLLWKK 285
Y + +RC + +WS+WS + + + P G E WR++ + V LLWK
Sbjct: 607 YAVQVRCKRLDGLGYWSNWSNPAYTVVMDIKVPMRGPEFWRIINGDTMKKEKNVTLLWKP 666
Query: 286 ARGAPVLEKTLGYNIWYYPESNTNLTETMNTTNQQLELHLGGESFWVSMISYNSLGKS-- 343
L Y I ++ N +E + + L ++ V++++ NS+G S
Sbjct: 667 LMKNDSLCSVQRYVINHHTSCNGTWSEDVGNHTKFTFLWTE-QAHTVTVLAINSIGASVA 725
Query: 344 --------PVATLRIPAIQEKSFQCIEVMQACVAEDQLVVKWQSSALDVNT--WMIEWFP 393
P++ + I +S + +CV +V W S D ++IEW
Sbjct: 726 NFNLTFSWPMSKVNIV----QSLSAYPLNSSCV-----IVSWILSPSDYKLMYFIIEW-- 774
Query: 394 DVDSEPTTLSWESVSQATNWTIQQDKLKPFWCYNISVYPMLHDKVGEPYSIQAYAKEGV 452
+E + W +S + D P Y S+YP+ + VG+P I ++ ++ +
Sbjct: 775 KNLNEDGEIKWLRISSSVKKYYIHDHFIPIEKYQFSLYPIFMEGVGKPKIINSFTQDDI 833
Score = 31.6 bits (70), Expect = 2.9
Identities = 45/224 (20%), Positives = 91/224 (40%), Gaps = 20/224 (8%)
Query: 35 WTWALWMLPSLCKFSLAALPAKPENISCVYYYRKNLTCTWSPGKETSYTQYTVKRTYAFG 94
W W+ L K + + + +N+ Y Y+ +L E S V + +F
Sbjct: 127 WNIQCWLKGDL-KLFICYVESLFKNLFRNYNYKVHLLYVLPEVLEDSPL---VPQKGSFQ 182
Query: 95 EKHDNCTTNSSTSENRASCSFFLPRITIPDNYTIEVEAENGDGVIKSHMTYWRLENIAKT 154
H NC+ + C +P + D + ++ +G + +S + + N+ K
Sbjct: 183 MVHCNCSVHEC-----CECLVPVPTAKLNDTLLMCLKITSGGVIFQSPLMSVQPINMVKP 237
Query: 155 EPPKIFRVKPVLGIKRMIQIEWIKPELAPVSSDLKYTLRFRTVNSTSWMEVNFAKNRKDK 214
+PP ++ + ++I W P L P L+Y +++ ++T E + K
Sbjct: 238 DPPLGLHME--ITDDGNLKISWSSPPLVPFP--LQYQVKYSENSTTVIREAD-----KIV 288
Query: 215 NQTYNLT-GLQPFTEYVIALRCAVKESK-FWSDWSQEKMGMTEE 256
+ T L + P + Y + +R + WSDWS ++ T++
Sbjct: 289 SATSLLVDSILPGSSYEVQVRGKRLDGPGIWSDWSTPRVFTTQD 332
>gi|40254464 leptin receptor isoform 1 [Homo sapiens]
Length = 1165
Score = 67.4 bits (163), Expect = 5e-11
Identities = 87/419 (20%), Positives = 165/419 (39%), Gaps = 43/419 (10%)
Query: 59 NISC-VYYYRKNLTCTWSPGKETSYTQYTVKRTYAFGEKHDNCTTNSSTSENRASC---- 113
NISC Y +TC WS S + T++ Y + + + C
Sbjct: 433 NISCETDGYLTKMTCRWSTSTIQSLAESTLQLRYHRSSLYCSDIPSIHPISEPKDCYLQS 492
Query: 114 -----SFFLPRITIPDNYTIEVEAENGDGVIKSHMTYWRLENIAKTEPPKIFRVKPVLGI 168
F P I + YT+ + + G + S T +++ K PP + + + I
Sbjct: 493 DGFYECIFQP-IFLLSGYTMWIRINHSLGSLDSPPTCVLPDSVVKPLPPSSVKAEITINI 551
Query: 169 KRMIQIEWIKPELAPVSSDLKYTLRFRTVNSTSWMEVNFAKNRKDKNQTYNLTGLQPFTE 228
+++I W KP ++L++ +R+ ++ + K K+ + + L
Sbjct: 552 G-LLKISWEKPVFP--ENNLQFQIRYGLSGKEVQWKMYEVYDAKSKSVSLPVPDL--CAV 606
Query: 229 YVIALRCAVKESK-FWSDWSQEKMGMTEE-EAPC-GLELWRVLKPAEADGRRPVRLLWKK 285
Y + +RC + +WS+WS + + + P G E WR++ + V LLWK
Sbjct: 607 YAVQVRCKRLDGLGYWSNWSNPAYTVVMDIKVPMRGPEFWRIINGDTMKKEKNVTLLWKP 666
Query: 286 ARGAPVLEKTLGYNIWYYPESNTNLTETMNTTNQQLELHLGGESFWVSMISYNSLGKS-- 343
L Y I ++ N +E + + L ++ V++++ NS+G S
Sbjct: 667 LMKNDSLCSVQRYVINHHTSCNGTWSEDVGNHTKFTFLWTE-QAHTVTVLAINSIGASVA 725
Query: 344 --------PVATLRIPAIQEKSFQCIEVMQACVAEDQLVVKWQSSALDVNT--WMIEWFP 393
P++ + I +S + +CV +V W S D ++IEW
Sbjct: 726 NFNLTFSWPMSKVNIV----QSLSAYPLNSSCV-----IVSWILSPSDYKLMYFIIEW-- 774
Query: 394 DVDSEPTTLSWESVSQATNWTIQQDKLKPFWCYNISVYPMLHDKVGEPYSIQAYAKEGV 452
+E + W +S + D P Y S+YP+ + VG+P I ++ ++ +
Sbjct: 775 KNLNEDGEIKWLRISSSVKKYYIHDHFIPIEKYQFSLYPIFMEGVGKPKIINSFTQDDI 833
Score = 31.6 bits (70), Expect = 2.9
Identities = 45/224 (20%), Positives = 91/224 (40%), Gaps = 20/224 (8%)
Query: 35 WTWALWMLPSLCKFSLAALPAKPENISCVYYYRKNLTCTWSPGKETSYTQYTVKRTYAFG 94
W W+ L K + + + +N+ Y Y+ +L E S V + +F
Sbjct: 127 WNIQCWLKGDL-KLFICYVESLFKNLFRNYNYKVHLLYVLPEVLEDSPL---VPQKGSFQ 182
Query: 95 EKHDNCTTNSSTSENRASCSFFLPRITIPDNYTIEVEAENGDGVIKSHMTYWRLENIAKT 154
H NC+ + C +P + D + ++ +G + +S + + N+ K
Sbjct: 183 MVHCNCSVHEC-----CECLVPVPTAKLNDTLLMCLKITSGGVIFQSPLMSVQPINMVKP 237
Query: 155 EPPKIFRVKPVLGIKRMIQIEWIKPELAPVSSDLKYTLRFRTVNSTSWMEVNFAKNRKDK 214
+PP ++ + ++I W P L P L+Y +++ ++T E + K
Sbjct: 238 DPPLGLHME--ITDDGNLKISWSSPPLVPFP--LQYQVKYSENSTTVIREAD-----KIV 288
Query: 215 NQTYNLT-GLQPFTEYVIALRCAVKESK-FWSDWSQEKMGMTEE 256
+ T L + P + Y + +R + WSDWS ++ T++
Sbjct: 289 SATSLLVDSILPGSSYEVQVRGKRLDGPGIWSDWSTPRVFTTQD 332
>gi|4759328 class I cytokine receptor [Homo sapiens]
Length = 636
Score = 63.5 bits (153), Expect = 7e-10
Identities = 89/389 (22%), Positives = 144/389 (37%), Gaps = 24/389 (6%)
Query: 223 LQPFTEYVIALRCAV-KESKFWSDWSQEKMGMTEEEAPCGLELWRVLKPAEADGRRPVRL 281
L+ T Y + RC + KE W +WS T AP ++W G L
Sbjct: 196 LELATGYKVYGRCRMEKEEDLWGEWSPILSFQTPPSAP--KDVWVSGNLCGTPGGEEPLL 253
Query: 282 LWKKARGAPVLEKTLGYNIWYYPESNTNLTETMNTTNQQLELHLGGESFWVSMISYNSLG 341
LWK AP + Y +W++ E + + G E W + + N+
Sbjct: 254 LWK----APGPCVQVSYKVWFWVGGRELSPEGITCCCSLIPS--GAE--WARVSAVNATS 305
Query: 342 KSPVATLRIPAIQEKSFQCIEVMQACVAEDQLVVKWQSSALDVNTWMIEWFPDVDSEPTT 401
P+ L + + S + + +L+V WQ + +++W D D
Sbjct: 306 WEPLTNLSLVCLDSASAPRSVAVSSIAGSTELLVTWQPGPGEPLEHVVDWARDGDPLEK- 364
Query: 402 LSWESVSQATNWTIQQDKLKPFWCYNISVYPMLHDKVGEPYSIQAYAKEGVPSEGPET-K 460
L+W + + Y I+V + + S+ + +E P GP +
Sbjct: 365 LNWVRLPPGNLSALLPGNFTVGVPYRITVTAVSASGLASASSVWGFREELAPLVGPTLWR 424
Query: 461 VENIGVKTVTITWKEIPKSERKGIICNYTIFYQAEGGKGFSKTVNSSILQYGLESLKRKT 520
+++ T I W E+P+ + +G + +YT+ Q+ V+ + L L
Sbjct: 425 LQDAPPGTPAIAWGEVPRHQLRGHLTHYTLCAQSGTSPSVCMNVSGNTQSVTLPDLPWGP 484
Query: 521 SYIVQVMASTSAG-GTNGTSINF----KTLSFSVFEIILI---TSLIGGGLLILIILTVA 572
+ V AST AG G G + TL + V IL L+G G L L
Sbjct: 485 CEL-WVTASTIAGQGPPGPILRLHLPDNTLRWKVLPGILFLWGLFLLGCG-LSLATSGRC 542
Query: 573 YGLKKPNKLTHLCWPTVPNPAESSIATWH 601
Y L+ L W VP+PA SS H
Sbjct: 543 YHLRH-KVLPRWVWEKVPDPANSSSGQPH 570
>gi|21359935 Down syndrome cell adhesion molecule like 1 [Homo
sapiens]
Length = 2113
Score = 63.5 bits (153), Expect = 7e-10
Identities = 57/248 (22%), Positives = 113/248 (45%), Gaps = 19/248 (7%)
Query: 301 WYYPESNTNLTETMNTTNQQLELHLGGESFWVSMISYNSLGKSPVATLRIPAIQEKSFQC 360
W + +S N++ T+N N ++LH + + M S+N +G+S + + +E +
Sbjct: 991 WDFKQSTRNISPTINQANI-VDLH-PASVYSIRMYSFNKIGRSEPSKELTISTEEAAPDG 1048
Query: 361 --IEVMQACVAEDQLVVKWQSSALDVNTWMIEWF--------PDVDSEPTTLSWESVSQA 410
++V V + V W++ ++ +I + P + + + + ++ +
Sbjct: 1049 PPMDVTLQPVTSQSIQVTWKAPKKELQNGVIRGYQIGYRENSPGSNGQYSIVEMKATGDS 1108
Query: 411 TNWTIQQDKLKPFWCYNISVYPMLHDKVGEPYS-IQAYAKEGVPSEGPET-KVENIGVKT 468
+T+ D LK F Y + V G S I A E VPS+ PE + +I
Sbjct: 1109 EVYTL--DNLKKFAQYGVVVQAFNRAGTGPSSSEINATTLEDVPSQPPENVRALSITSDV 1166
Query: 469 VTITWKEIPKSERKGIICNYTIFYQA---EGGKGFSKTVNSSILQYGLESLKRKTSYIVQ 525
I+W E P+S G++ Y + + + +G G + + ++ + L +++ T+Y VQ
Sbjct: 1167 AVISWSEPPRSTLNGVLKGYRVIFWSLYVDGEWGEMQNITTTRERVELRGMEKFTNYSVQ 1226
Query: 526 VMASTSAG 533
V+A T AG
Sbjct: 1227 VLAYTQAG 1234
Score = 52.4 bits (124), Expect = 2e-06
Identities = 89/395 (22%), Positives = 155/395 (39%), Gaps = 50/395 (12%)
Query: 180 ELAPVSSDLKYTLRFRTVNSTSWMEVNFAKNRKDK--------------NQTYNLTGLQP 225
E+ S +L++T RF + + ++ + KN+ D NQ N+ L P
Sbjct: 957 EVKARSMNLRWTQRFDGNSIITGFDIEY-KNKSDSWDFKQSTRNISPTINQA-NIVDLHP 1014
Query: 226 FTEYVIALRCAVKESKFWSDWSQEKMGMTEEEAPCGLELWRVLKPAEADGRRPVRLLWKK 285
+ Y I + K + S+ S+E TEE AP G + L+P + +++ WK
Sbjct: 1015 ASVYSIRMYSFNKIGR--SEPSKELTISTEEAAPDGPPMDVTLQPVTSQS---IQVTWKA 1069
Query: 286 ARGAPVLEKTLGYNIWYY---PESN-----TNLTETMNTTNQQLELHLGGESFWVSMISY 337
+ GY I Y P SN + T ++ L+ + V + ++
Sbjct: 1070 PKKELQNGVIRGYQIGYRENSPGSNGQYSIVEMKATGDSEVYTLDNLKKFAQYGVVVQAF 1129
Query: 338 NSLGKSPVAT-LRIPAIQEKSFQCIEVMQAC-VAEDQLVVKWQSSALDVNTWMIE----- 390
N G P ++ + +++ Q E ++A + D V+ W +++
Sbjct: 1130 NRAGTGPSSSEINATTLEDVPSQPPENVRALSITSDVAVISWSEPPRSTLNGVLKGYRVI 1189
Query: 391 -WFPDVDSEPTTLSWESVSQATNWT--IQQDKLKPFWCYNISVYPMLHDKVGEPYSI-QA 446
W VD E W + T ++ ++ F Y++ V G S+
Sbjct: 1190 FWSLYVDGE-----WGEMQNITTTRERVELRGMEKFTNYSVQVLAYTQAGDGVRSSVLYI 1244
Query: 447 YAKEGVPSEGPETKVENIGVKTVTITWKEIPKSERKGIICNYTIFYQAEG-GKGFSKTVN 505
KE VP K +V ++W +P ++ G+I YTIF + G G+
Sbjct: 1245 QTKEDVPGPPAGIKAVPSSASSVVVSW--LPPTKPNGVIRKYTIFCSSPGSGQPAPSEYE 1302
Query: 506 SSILQ--YGLESLKRKTSYIVQVMASTSAGGTNGT 538
+S Q Y + L R Y++ V A TSAG N +
Sbjct: 1303 TSPEQLFYRIAHLNRGQQYLLWVAAVTSAGRGNSS 1337
Score = 48.9 bits (115), Expect = 2e-05
Identities = 72/291 (24%), Positives = 130/291 (44%), Gaps = 34/291 (11%)
Query: 273 ADGRRPVRLLWKKARGAPVLEKTLGYNIWYYPESNTNLTETMNTTNQQLELHLGGESFWV 332
A G RP+ + W+K ++ + Y I + N E ++T +L+ G+S +
Sbjct: 872 ARGERPIIIRWEKGDTVIDPDRVMRYAI----ATKDNGDEVVSTL--KLKPADRGDSVFF 925
Query: 333 SMISYNSLGKSPVATLRIPAIQEKSFQCIEVMQACVAEDQLVVKWQSSALDVNTWMIEWF 392
S + NS G+ +++ + +E+ + V + ++W + D N+ +I F
Sbjct: 926 SCHAINSYGEDR-GLIQLTVQEPPDPPELEIRE--VKARSMNLRW-TQRFDGNS-IITGF 980
Query: 393 PDVDSEPTTLSWESVSQATNW--TIQQDK---LKPFWCYNISVYPMLHDKVG--EPYSIQ 445
D++ + + SW+ N TI Q L P Y+I +Y +K+G EP
Sbjct: 981 -DIEYKNKSDSWDFKQSTRNISPTINQANIVDLHPASVYSIRMYSF--NKIGRSEPSKEL 1037
Query: 446 AYAKEGVPSEGP--ETKVENIGVKTVTITWKEIPKSERKGIICNYTIFYQ--AEGGKG-- 499
+ E +GP + ++ + +++ +TWK K + G+I Y I Y+ + G G
Sbjct: 1038 TISTEEAAPDGPPMDVTLQPVTSQSIQVTWKAPKKELQNGVIRGYQIGYRENSPGSNGQY 1097
Query: 500 ----FSKTVNSSILQYGLESLKRKTSYIVQVMASTSAG-GTNGTSINFKTL 545
T +S + Y L++LK+ Y V V A AG G + + IN TL
Sbjct: 1098 SIVEMKATGDSEV--YTLDNLKKFAQYGVVVQAFNRAGTGPSSSEINATTL 1146
Score = 30.8 bits (68), Expect = 4.9
Identities = 54/287 (18%), Positives = 113/287 (39%), Gaps = 58/287 (20%)
Query: 274 DGRRPVRLLWKKARGAPVLEKTLGYNIWYYPESNTNLTETMNTTNQQLELHLGGESFWVS 333
DG P +++WK A+G+ G Y+P T + + ++ + L + +
Sbjct: 774 DGYPPPKVMWKHAKGS-------GNPQQYHPVPLTGRIQILPNSSLLIRHVLEEDIGYYL 826
Query: 334 MISYNSLG----KSPVATLRIPAIQEKSFQCIEVMQA------CVA--EDQLVVKWQSSA 381
+ N +G KS T++IPA+ ++ C A E ++++W+
Sbjct: 827 CQASNGVGTDISKSMFLTVKIPAMITSHPNTTIAIKGHAKELNCTARGERPIIIRWEKG- 885
Query: 382 LDVNTWMIEWFPDVDSEPTTLSWESVSQATNW--TIQQDKLKP--------FWCYNISVY 431
D +P + +++ N + KLKP F C+ I+ Y
Sbjct: 886 ------------DTVIDPDRVMRYAIATKDNGDEVVSTLKLKPADRGDSVFFSCHAINSY 933
Query: 432 PMLHDKVGEPYS-IQAYAKEGVPSEGPETKVENIGVKTVTITWKEIPKSERKGIICNYTI 490
GE IQ +E P + PE ++ + +++ + W + + + II + I
Sbjct: 934 -------GEDRGLIQLTVQE--PPDPPELEIREVKARSMNLRWTQ--RFDGNSIITGFDI 982
Query: 491 FYQAEGG----KGFSKTVNSSILQYGLESLKRKTSYIVQVMASTSAG 533
Y+ + K ++ ++ +I Q + L + Y +++ + G
Sbjct: 983 EYKNKSDSWDFKQSTRNISPTINQANIVDLHPASVYSIRMYSFNKIG 1029
>gi|24430212 interleukin 23 receptor precursor [Homo sapiens]
Length = 629
Score = 57.8 bits (138), Expect = 4e-08
Identities = 57/212 (26%), Positives = 86/212 (40%), Gaps = 22/212 (10%)
Query: 54 PAKPENISCVYY-YRKNLTCTWSPGKETSY-TQYTVKRTYAFGEKHDNCTTNSSTSENRA 111
P P+ ++CV Y Y N+TCTW+ GK T T+Y V E+ T+S + +
Sbjct: 125 PDIPDEVTCVIYEYSGNMTCTWNAGKLTYIDTKYVVHVKSLETEEEQQYLTSSYINISTD 184
Query: 112 SCSFFLPRITIPDNYTIEVEAENGDGVIKSHMTYWRLENIAKTEPPKIFRVKPVLGIKRM 171
S + Y + V+A N G+ +S L++I I R + +
Sbjct: 185 S-------LQGGKKYLVWVQAANALGMEESKQLQIHLDDIVIPSAAVISRAETINATVPK 237
Query: 172 IQIEW-IKPELAPVSSDLKYTLRFRTVNSTSWMEVNFAKNRKDKNQTYNLTG---LQPFT 227
I W + + VS +++Y T N T W F D N TY L+P
Sbjct: 238 TIIYWDSQTTIEKVSCEMRYKA---TTNQT-WNVKEF-----DTNFTYVQQSEFYLEPNI 288
Query: 228 EYVIALRCAVKESKFWSDWSQEKMGMTEEEAP 259
+YV +RC ++W WS T E P
Sbjct: 289 KYVFQVRCQETGKRYWQPWSSLFFHKTPETVP 320
>gi|4506107 prolactin receptor [Homo sapiens]
Length = 622
Score = 57.4 bits (137), Expect = 5e-08
Identities = 53/224 (23%), Positives = 89/224 (39%), Gaps = 14/224 (6%)
Query: 30 NLGMMWTWALWMLPSLCKFSLAALPAKPENISCVYYYRKNLTCTWSPGKETSY-TQYTVK 88
N+ + L + + C + P KPE C ++ TC W PG + T Y++
Sbjct: 4 NVASATVFTLLLFLNTCLLNGQLPPGKPEIFKCRSPNKETFTCWWRPGTDGGLPTNYSLT 63
Query: 89 RTYAFGEKHDNCTTNSSTSENRASCSFFLPRITIPDNYTIEVEAENGDGVIKSHMTYWRL 148
C + N SC F ++ Y + V A N G S Y +
Sbjct: 64 YHREGETLMHECPDYITGGPN--SCHFGKQYTSMWRTYIMMVNATNQMGSSFSDELYVDV 121
Query: 149 ENIAKTEPP--KIFRVKPVLGIKRMIQIEWIKPELAPVSS---DLKYTLRFRTVNSTSWM 203
I + +PP VK K + I+W P L + + L Y +R + + W
Sbjct: 122 TYIVQPDPPLELAVEVKQPEDRKPYLWIKWSPPTLIDLKTGWFTLLYEIRLKPEKAAEW- 180
Query: 204 EVNFAKNRKDKNQTYNLTGLQPFTEYVIALRCAVKESKFWSDWS 247
E++FA + + + + L P +Y++ +RC + +WS WS
Sbjct: 181 EIHFAGQQTE----FKILSLHPGQKYLVQVRCK-PDHGYWSAWS 219
>gi|109633041 protein tyrosine phosphatase, receptor type, F isoform
1 precursor [Homo sapiens]
Length = 1907
Score = 57.4 bits (137), Expect = 5e-08
Identities = 79/341 (23%), Positives = 139/341 (40%), Gaps = 48/341 (14%)
Query: 218 YNLTGLQPFTEYVIALRCAVKESKFWSDWSQEKMGMTEEEAPCGLELWRVLKPAEADGRR 277
Y++ GL PF+EY A R S S+ T E+AP P R
Sbjct: 374 YSIGGLSPFSEY--AFRVLAVNSIGRGPPSEAVRARTGEQAPSS-------PPRRVQARM 424
Query: 278 ----PVRLLWKKARGAPVLEKTLGYNIWYYPESNT--------NLTETMNTTNQQLELHL 325
+ + W+ L + GY ++Y P+S N + TT L L
Sbjct: 425 LSASTMLVQWEPPEEPNGLVR--GYRVYYTPDSRRPPNAWHKHNTDAGLLTTVGSL---L 479
Query: 326 GGESFWVSMISYNSLGKSPVATLRIPAIQEKSFQCIEVM----QACVAED-QLVVKWQSS 380
G ++ + ++++ ++G P + P IQ K+ Q + QA V D ++ + W
Sbjct: 480 PGITYSLRVLAFTAVGDGPPS----PTIQVKTQQGVPAQPADFQAEVESDTRIQLSWLLP 535
Query: 381 ALD--VNTWMIEWFPDVDSEPTTLSWESVSQATNWTIQQDKLKPFWCYNISVYPMLHDKV 438
+ + ++ W + + + ++++ S T + LKP Y + V
Sbjct: 536 PQERIIMYELVYWAAEDEDQQHKVTFDPTSSYT-----LEDLKPDTLYRFQLAARSDMGV 590
Query: 439 GE-PYSIQAYAKEGVPSEGPETKV-ENIGVKTVTITWKEIPKSERKGIICNYTIFYQAEG 496
G +I+A + PS P+ + ++G TV ++W P R G+I Y++ Y+A
Sbjct: 591 GVFTPTIEARTAQSTPSAPPQKVMCVSMGSTTVRVSWVPPPADSRNGVITQYSVAYEAVD 650
Query: 497 GKGFSKTVNSSILQ----YGLESLKRKTSYIVQVMASTSAG 533
G+ + V I + + L L++ T Y V V A T G
Sbjct: 651 GEDRGRHVVDGISREHSSWDLVGLEKWTEYRVWVRAHTDVG 691
Score = 44.3 bits (103), Expect = 4e-04
Identities = 96/532 (18%), Positives = 199/532 (37%), Gaps = 73/532 (13%)
Query: 53 LPAKPENISCVYYYRKNLTCTWSPGKETSYTQYTVKRTYAFGEKHDNCTTNSSTSENRAS 112
+PA+P + + +W + Y + A E + T TS
Sbjct: 511 VPAQPADFQAEVESDTRIQLSWLLPPQERIIMYELVYWAAEDEDQQHKVTFDPTS----- 565
Query: 113 CSFFLPRITIPDNYTIEVEAEN--GDGVIKSHMTYWRLENIAKTEPPKIFRVKPVLGIKR 170
S+ L + Y ++ A + G GV + ++ P K+ V +G
Sbjct: 566 -SYTLEDLKPDTLYRFQLAARSDMGVGVFTPTIEARTAQSTPSAPPQKVMCVS--MG-ST 621
Query: 171 MIQIEWIKPELAPVSSDL-KYTLRFRTVNSTSWMEVNFAKNRKDKNQTYNLTGLQPFTEY 229
+++ W+ P + + +Y++ + V+ + ++ +++L GL+ +TEY
Sbjct: 622 TVRVSWVPPPADSRNGVITQYSVAYEAVDGEDRGR-HVVDGISREHSSWDLVGLEKWTEY 680
Query: 230 VIALRCAVKESKFWSDWSQEKMGMTEEEAPCG----LEL-----------WRVLKPAEAD 274
+ +R S + T+E+ P G +E+ W++ P++
Sbjct: 681 RVWVRAHTDVGP--GPESSPVLVRTDEDVPSGPPRKVEVEPLNSTAVHVYWKLPVPSKQH 738
Query: 275 GR------RPVRLLWKKARGAPVLEKTLGYNIWYYPESNTNLTETMNTTNQQLELHLGGE 328
G+ VRL + RG P+++ + + PE + + T++ +
Sbjct: 739 GQIRGYQVTYVRLENGEPRGLPIIQDVMLAEAQWRPEESEDYETTISGLTPET------- 791
Query: 329 SFWVSMISYNSLGKSPVATLRIPAIQEKSFQCIEVMQACVAEDQLVVKWQSSALDVNTWM 388
++ V++ +Y + G + +I + A +++ S +NT +
Sbjct: 792 TYSVTVAAYTTKGDGARSKPKI----------VTTTGAVPGRPTMMI----STTAMNTAL 837
Query: 389 IEWFPDVDSEPTTLSWE----SVSQATNWTIQQDK---------LKPFWCYNISVYPMLH 435
++W P + L + +A TI K L Y +
Sbjct: 838 LQWHPPKELPGELLGYRLQYCRADEARPNTIDFGKDDQHFTVTGLHKGTTYIFRLAAKNR 897
Query: 436 DKVGEPYSIQAYAKEGVPSEGPET-KVENIGVKTVTITWKEIPKSERKGIICNYTIFYQA 494
+GE + + E +PS P+ V + T + W +ER G I +YT+ ++
Sbjct: 898 AGLGEEFEKEIRTPEDLPSGFPQNLHVTGLTTSTTELAWDPPVLAERNGRIISYTVVFRD 957
Query: 495 EGGKGFSKTVNSSILQYGLESLKRKTSYIVQVMASTSAG-GTNGTSINFKTL 545
+ + + + ++ L LK T+Y ++V A TS G G SI +T+
Sbjct: 958 INSQQELQNITTD-TRFTLTGLKPDTTYDIKVRAWTSKGSGPLSPSIQSRTM 1008
>gi|109633039 protein tyrosine phosphatase, receptor type, F isoform
2 precursor [Homo sapiens]
Length = 1898
Score = 57.4 bits (137), Expect = 5e-08
Identities = 79/341 (23%), Positives = 139/341 (40%), Gaps = 48/341 (14%)
Query: 218 YNLTGLQPFTEYVIALRCAVKESKFWSDWSQEKMGMTEEEAPCGLELWRVLKPAEADGRR 277
Y++ GL PF+EY A R S S+ T E+AP P R
Sbjct: 374 YSIGGLSPFSEY--AFRVLAVNSIGRGPPSEAVRARTGEQAPSS-------PPRRVQARM 424
Query: 278 ----PVRLLWKKARGAPVLEKTLGYNIWYYPESNT--------NLTETMNTTNQQLELHL 325
+ + W+ L + GY ++Y P+S N + TT L L
Sbjct: 425 LSASTMLVQWEPPEEPNGLVR--GYRVYYTPDSRRPPNAWHKHNTDAGLLTTVGSL---L 479
Query: 326 GGESFWVSMISYNSLGKSPVATLRIPAIQEKSFQCIEVM----QACVAED-QLVVKWQSS 380
G ++ + ++++ ++G P + P IQ K+ Q + QA V D ++ + W
Sbjct: 480 PGITYSLRVLAFTAVGDGPPS----PTIQVKTQQGVPAQPADFQAEVESDTRIQLSWLLP 535
Query: 381 ALD--VNTWMIEWFPDVDSEPTTLSWESVSQATNWTIQQDKLKPFWCYNISVYPMLHDKV 438
+ + ++ W + + + ++++ S T + LKP Y + V
Sbjct: 536 PQERIIMYELVYWAAEDEDQQHKVTFDPTSSYT-----LEDLKPDTLYRFQLAARSDMGV 590
Query: 439 GE-PYSIQAYAKEGVPSEGPETKV-ENIGVKTVTITWKEIPKSERKGIICNYTIFYQAEG 496
G +I+A + PS P+ + ++G TV ++W P R G+I Y++ Y+A
Sbjct: 591 GVFTPTIEARTAQSTPSAPPQKVMCVSMGSTTVRVSWVPPPADSRNGVITQYSVAYEAVD 650
Query: 497 GKGFSKTVNSSILQ----YGLESLKRKTSYIVQVMASTSAG 533
G+ + V I + + L L++ T Y V V A T G
Sbjct: 651 GEDRGRHVVDGISREHSSWDLVGLEKWTEYRVWVRAHTDVG 691
Score = 40.8 bits (94), Expect = 0.005
Identities = 96/522 (18%), Positives = 188/522 (36%), Gaps = 62/522 (11%)
Query: 53 LPAKPENISCVYYYRKNLTCTWSPGKETSYTQYTVKRTYAFGEKHDNCTTNSSTSENRAS 112
+PA+P + + +W + Y + A E + T TS
Sbjct: 511 VPAQPADFQAEVESDTRIQLSWLLPPQERIIMYELVYWAAEDEDQQHKVTFDPTS----- 565
Query: 113 CSFFLPRITIPDNYTIEVEAEN--GDGVIKSHMTYWRLENIAKTEPPKIFRVKPVLGIKR 170
S+ L + Y ++ A + G GV + ++ P K+ V +G
Sbjct: 566 -SYTLEDLKPDTLYRFQLAARSDMGVGVFTPTIEARTAQSTPSAPPQKVMCVS--MG-ST 621
Query: 171 MIQIEWIKPELAPVSSDL-KYTLRFRTVNSTSWMEVNFAKNRKDKNQTYNLTGLQPFTEY 229
+++ W+ P + + +Y++ + V+ + ++ +++L GL+ +TEY
Sbjct: 622 TVRVSWVPPPADSRNGVITQYSVAYEAVDGEDRGR-HVVDGISREHSSWDLVGLEKWTEY 680
Query: 230 VIALRCAVKESKFWSDWSQEKMGMTEEEAPCGLELWRVLKPAEADGRRPVRLLWKKARGA 289
+ +R S + T+E+ P G ++P + V + WK +
Sbjct: 681 RVWVRAHTDVGP--GPESSPVLVRTDEDVPSGPPRKVEVEPLNSTA---VHVYWKLPVPS 735
Query: 290 PVLEKTLGYNIWYYPESNTN-----------LTETMNTTNQQLELHLGGESFWVSMISYN 338
+ GY + Y N L E TT L ++ V++ +Y
Sbjct: 736 KQHGQIRGYQVTYVRLENGEPRGLPIIQDVMLAEAQETTISGLTPET---TYSVTVAAYT 792
Query: 339 SLGKSPVATLRIPAIQEKSFQCIEVMQACVAEDQLVVKWQSSALDVNTWMIEWFPDVDSE 398
+ G + +I + A +++ S +NT +++W P +
Sbjct: 793 TKGDGARSKPKI----------VTTTGAVPGRPTMMI----STTAMNTALLQWHPPKELP 838
Query: 399 PTTLSWE----SVSQATNWTIQQDK---------LKPFWCYNISVYPMLHDKVGEPYSIQ 445
L + +A TI K L Y + +GE + +
Sbjct: 839 GELLGYRLQYCRADEARPNTIDFGKDDQHFTVTGLHKGTTYIFRLAAKNRAGLGEEFEKE 898
Query: 446 AYAKEGVPSEGPET-KVENIGVKTVTITWKEIPKSERKGIICNYTIFYQAEGGKGFSKTV 504
E +PS P+ V + T + W +ER G I +YT+ ++ + + +
Sbjct: 899 IRTPEDLPSGFPQNLHVTGLTTSTTELAWDPPVLAERNGRIISYTVVFRDINSQQELQNI 958
Query: 505 NSSILQYGLESLKRKTSYIVQVMASTSAG-GTNGTSINFKTL 545
+ ++ L LK T+Y ++V A TS G G SI +T+
Sbjct: 959 TTD-TRFTLTGLKPDTTYDIKVRAWTSKGSGPLSPSIQSRTM 999
>gi|22212918 ciliary neurotrophic factor receptor preproprotein
[Homo sapiens]
Length = 372
Score = 54.7 bits (130), Expect = 3e-07
Identities = 51/198 (25%), Positives = 77/198 (38%), Gaps = 13/198 (6%)
Query: 53 LPAKPENISC-VYYYRKNLTCTWSPGKETSYTQYTVKRTYAFGEKHDNCTTNSSTSENRA 111
LP + +SC Y K C+W T Y T T G K C + + +NR
Sbjct: 107 LPPREPVLSCRSNTYPKGFYCSWHLPTPT-YIPNTFNVTVLHGSKIMVCEKDPAL-KNRC 164
Query: 112 SCSFFLPRITIPDNYTIEVEAENGDGVIKSHMTYWRLENIAKTEPPKIFRVKPVLGIKRM 171
+ TI Y + + N G + +T+ I K +PP+ +PV R
Sbjct: 165 HIRYMHLFSTI--KYKVSISVSNALGHNATAITFDEF-TIVKPDPPENVVARPVPSNPRR 221
Query: 172 IQIEWIKPEL--APVSSDLKYTLRFRTVNSTSWMEVNFAKNRKDKNQTYNLTGLQPFTEY 229
+++ W P P S LK+ LR+R + W V + + +T EY
Sbjct: 222 LEVTWQTPSTWPDPESFPLKFFLRYRPLILDQWQHVELS-----DGTAHTITDAYAGKEY 276
Query: 230 VIALRCAVKESKFWSDWS 247
+I + E WSDWS
Sbjct: 277 IIQVAAKDNEIGTWSDWS 294
>gi|4502931 ciliary neurotrophic factor receptor preproprotein [Homo
sapiens]
Length = 372
Score = 54.7 bits (130), Expect = 3e-07
Identities = 51/198 (25%), Positives = 77/198 (38%), Gaps = 13/198 (6%)
Query: 53 LPAKPENISC-VYYYRKNLTCTWSPGKETSYTQYTVKRTYAFGEKHDNCTTNSSTSENRA 111
LP + +SC Y K C+W T Y T T G K C + + +NR
Sbjct: 107 LPPREPVLSCRSNTYPKGFYCSWHLPTPT-YIPNTFNVTVLHGSKIMVCEKDPAL-KNRC 164
Query: 112 SCSFFLPRITIPDNYTIEVEAENGDGVIKSHMTYWRLENIAKTEPPKIFRVKPVLGIKRM 171
+ TI Y + + N G + +T+ I K +PP+ +PV R
Sbjct: 165 HIRYMHLFSTI--KYKVSISVSNALGHNATAITFDEF-TIVKPDPPENVVARPVPSNPRR 221
Query: 172 IQIEWIKPEL--APVSSDLKYTLRFRTVNSTSWMEVNFAKNRKDKNQTYNLTGLQPFTEY 229
+++ W P P S LK+ LR+R + W V + + +T EY
Sbjct: 222 LEVTWQTPSTWPDPESFPLKFFLRYRPLILDQWQHVELS-----DGTAHTITDAYAGKEY 276
Query: 230 VIALRCAVKESKFWSDWS 247
+I + E WSDWS
Sbjct: 277 IIQVAAKDNEIGTWSDWS 294
>gi|222537743 protein tyrosine phosphatase, receptor type, Q [Homo
sapiens]
Length = 2299
Score = 54.3 bits (129), Expect = 4e-07
Identities = 56/194 (28%), Positives = 87/194 (44%), Gaps = 14/194 (7%)
Query: 355 EKSFQCIEVMQACVAEDQLVVKWQSSALDVNTWMIEWFPDVDSEPTTLSWESVSQATNWT 414
E S Q +EV+ V D++ +KW S + +I + + TL ++ S
Sbjct: 666 ESSPQDVEVID--VTADEIRLKW--SPPEKPNGIIIAYEVLYKNIDTLYMKNTSTTD--- 718
Query: 415 IQQDKLKPFWCYNISVYPMLHDKVGEPYS--IQAYAKEGVPSEGPET-KVENIGVKTVTI 471
I L+P YNISV G S + E VP PE +NI + +
Sbjct: 719 IILRNLRPHTLYNISVRSYTRFGHGNQVSSLLSVRTSETVPDSAPENITYKNISSGEIEL 778
Query: 472 TWKEIPKSERKGIICNYTIFYQAEGGKGFSKTVNSSILQYGLESLKRKTSYIVQVMASTS 531
++ +P S GII YTI+ + G +T+N++ L ++ LK+ T YI++V AST
Sbjct: 779 SF--LPPSSPNGIIQKYTIYLKRSNGNE-ERTINTTSLTQNIKVLKKYTQYIIEVSASTL 835
Query: 532 AG-GTNGTSINFKT 544
G G I+ T
Sbjct: 836 KGEGVRSAPISILT 849
Score = 39.7 bits (91), Expect = 0.011
Identities = 43/181 (23%), Positives = 74/181 (40%), Gaps = 10/181 (5%)
Query: 371 DQLVVKWQSSALDVNTWMIEWFPDVDSEPTTLSWESVSQATNWTIQQDKLKPFWCYNISV 430
D + +KW S L + F + E T+ ++++S + L+P Y+I V
Sbjct: 1257 DFVWLKWSPSPLPGGIVKVYSFKIHEHETDTIYYKNIS-GFKTEAKLVGLEPVSTYSIRV 1315
Query: 431 YPMLHDKVGEPYS--IQAYAKEGVPSEGPETKVENIGVKTVTITWKEIPKSERKGIICNY 488
G +S ++ +E VP + ++V + W P + GII Y
Sbjct: 1316 SAFTKVGNGNQFSNVVKFTTQESVPDVVQNMQCMATSWQSVLVKWD--PPKKANGIITQY 1373
Query: 489 TIFYQAEGGKGFSKTVNSSILQYGLESLKRKTSYIVQVMASTSAGGTNGTSINFKTLSFS 548
+ + K V+ Y L TSY+ +V ASTSAG + ++ + TL +
Sbjct: 1374 MVTVERNSTK-----VSPQDHMYTFIKLLANTSYVFKVRASTSAGEGDESTCHVSTLPET 1428
Query: 549 V 549
V
Sbjct: 1429 V 1429
Score = 39.3 bits (90), Expect = 0.014
Identities = 33/117 (28%), Positives = 54/117 (46%), Gaps = 7/117 (5%)
Query: 419 KLKPFWCYNISVYPMLHDKVGEPYSIQAYAKEGVPSEGPETKVENIGVKTVTITWKEIPK 478
+L PF + ISV G P + ++ VPS +NI ++ + W P
Sbjct: 535 RLVPFTEHMISVSAFTIMGEGPPTVLSVRTRQQVPSSIKIINYKNISSSSILLYWD--PP 592
Query: 479 SERKGIICNYTIF-YQAEGGKGFS-KTVNSSILQYGLESLKRKTSYIVQVMASTSAG 533
G I +YTI+ + + + F T+++S L + LK+ T Y ++V AST G
Sbjct: 593 EYPNGKITHYTIYAMELDTNRAFQITTIDNSFL---ITGLKKYTKYKMRVAASTHVG 646
Score = 32.0 bits (71), Expect = 2.2
Identities = 57/263 (21%), Positives = 95/263 (36%), Gaps = 42/263 (15%)
Query: 302 YYPESNTNLTETMNTTNQQLELH-LGGESFWVSMISYNSLGKSPVATLRIPAIQEKSFQC 360
Y SN N T+NTT+ + L + ++ +S ++L V + I + E+
Sbjct: 796 YLKRSNGNEERTINTTSLTQNIKVLKKYTQYIIEVSASTLKGEGVRSAPISILTEED--- 852
Query: 361 IEVMQACVAEDQLVVKWQSSALDVNTWMIEWFPDVDSEP-----TTLSWESVSQATNWTI 415
A D + L T + W P ++ T W S T
Sbjct: 853 --------APDSPPQDFSVKQLSGVTVKLSWQPPLEPNGIILYYTVYVWNRSSLKTINVT 904
Query: 416 QQDKLKPFWCYNI--SVYPMLHDKVGEPYS----IQAYAKEGVPSEGP-ETKVENIGVKT 468
+ YN+ S Y + G+ + I EG PS+ P + N+ +
Sbjct: 905 ETSLELSDLDYNVEYSAYVTASTRFGDGKTRSNIISFQTPEGAPSDPPKDVYYANLSSSS 964
Query: 469 VTITWKEIPKSERKGIICNYTIFYQAEGG------------KGFSKTVNSSILQYGLESL 516
+ + W P S+ GII Y+++Y+ G F S+I ++ L
Sbjct: 965 IILFWT--PPSKPNGIIQYYSVYYRNTSGTFMQNFTLHEVTNDFDNMTVSTI----IDKL 1018
Query: 517 KRKTSYIVQVMASTSAGGTNGTS 539
+ Y + ASTS G N +S
Sbjct: 1019 TIFSYYTFWLTASTSVGNGNKSS 1041
>gi|93141047 collagen, type XII, alpha 1 long isoform precursor [Homo
sapiens]
Length = 3063
Score = 53.1 bits (126), Expect = 9e-07
Identities = 110/507 (21%), Positives = 183/507 (36%), Gaps = 61/507 (12%)
Query: 51 AALPAKPENISCVYYYRKNLTCTWSPGKETSYTQYTVKRTYAFGEKHDNCTTNSSTSENR 110
A +P K + S V Y WSP E ++ + TY D T S
Sbjct: 631 AYVPPKDLSFSEVTSY--GFKTNWSPAGENVFSYHI---TYKEAAGDDEVTVVEPASSTS 685
Query: 111 ASCSFFLPRITIPDNYTIEVEAENGDGVIKSHMTYWRLENIAKTEPPKIFRVKPVLGIKR 170
S P Y + V AE DG E + K P + K
Sbjct: 686 VVLSSLKPETL----YLVNVTAEYEDGFSIPLAGEETTEEV-KGAPRNL---KVTDETTD 737
Query: 171 MIQIEWIKPELAPVSSDLKYTLRFRTVNSTSWMEVNFAKNRKDKNQTYNLTGLQPFTEYV 230
+I W + AP L+Y + +R V EV N++ + L L P T+Y
Sbjct: 738 SFKITWTQ---AP-GRVLRYRIIYRPVAGGESREVTTPPNQRRRT----LENLIPDTKYE 789
Query: 231 IALRCAVKESKFWSDWSQEKMGMTEEEAPCGLELWRVLKPAEADGRRPVRLLWKKARGAP 290
++ V F + EE RV P + ++L W A G
Sbjct: 790 VS----VIPEYFSGPGTPLTGNAATEEVRGNPRDLRVSDPTTST----MKLSWSGAPG-- 839
Query: 291 VLEKTLGYNIWYYPESNTNLTETM---NTTNQQLELHLGGESFWVSMISYNSLGKSPVAT 347
K Y + Y P + E +TTN L+ G + +S+ + + G
Sbjct: 840 ---KVKQYLVTYTPVAGGETQEVTVRGDTTNTVLQGLKEGTQYALSVTALYASGAGDALF 896
Query: 348 LRIPAIQEKSFQCIEVMQACVAEDQLVVKWQSSALDVNTWMIEW---FPDVDSEPTTLSW 404
++E+ +++ + + + W S+ V + + W + DVD+ L
Sbjct: 897 GEGTTLEERGSPQ-DLVTKDITDTSIGAYWTSAPGMVRGYRVSWKSLYDDVDTGEKNLPE 955
Query: 405 ESVSQATNWTIQQDKLKPFWCYNISVYPMLHDKVGEPYSIQAYAKEGVPSEGPETKVENI 464
+++ + L+P Y ISV+ GEP + A + + + KV+
Sbjct: 956 DAIHTMI------ENLQPETKYRISVFATYSSGEGEPLTGDATTE--LSQDSKTLKVDEE 1007
Query: 465 GVKTVTITWKEIPKSERKGIICNYTIFYQAEG-GKGFSKTVNSSILQYGLESLKRKTSYI 523
T+ +TWK P G + NY + Y+ G GK V ++ L+ L+ +T+Y
Sbjct: 1008 TENTMRVTWKPAP-----GKVVNYRVVYRPHGRGKQMVAKVPPTVTSTVLKRLQPQTTYD 1062
Query: 524 VQVMASTSAG------GTNGTSINFKT 544
+ V+ G G+ T+ FK+
Sbjct: 1063 ITVLPIYKMGEGKLRQGSGTTASRFKS 1089
Score = 46.6 bits (109), Expect = 9e-05
Identities = 79/355 (22%), Positives = 135/355 (38%), Gaps = 38/355 (10%)
Query: 183 PVSSDLKYTLRFRTVNSTSWMEVNFAKNRKDKNQTYNLTGLQPFTEYVIALRCAVKESKF 242
PV Y L ++ V T + N LT L P TEY + ++ +
Sbjct: 1496 PVGGATGYILSYKPVKDTEPTRPKEVRLGPTVNDM-QLTDLVPNTEYAVTVQAVLH---- 1550
Query: 243 WSDWSQEKMGMTEEEAPCGLELWRVLKPAEADGRRPVRLLWKKARGAPVLEKTLGYNIWY 302
D + E + + E P L + LK + + + W+ PV K Y + Y
Sbjct: 1551 --DLTSEPVTVREVTLP--LPRPQDLKLRDVT-HSTMNVFWE-----PVPGKVRKYIVRY 1600
Query: 303 Y-PESNTNLTET-MNTTNQQLELHLGGESFWVSMISYNSLGKSPVATLRIPAIQEKSFQC 360
PE + E + T+ L+ + VS+ + + G+SP T + +
Sbjct: 1601 KTPEEDVKEVEVDRSETSTSLKDLFSQTLYTVSVSAVHDEGESPPVTAQETTRPVPAPTN 1660
Query: 361 IEVMQACVAEDQLVVKWQSSALDVNTWMIEWFPDVDSEPTTLSWESVSQATNWTIQQDKL 420
+++ + V + W A DV+ + I W P S+ E++ T+ + L
Sbjct: 1661 LKITE--VTSEGFRGTWDHGASDVSLYRITWAPFGSSD----KMETILNGDENTLVFENL 1714
Query: 421 KPFWCYNISVYPMLHDK------VGEPYSIQAYAKEGVPSEGPET-KVENIGVKTVTITW 473
P Y +S+ + D+ +G ++ + P GP +V N ++T+ W
Sbjct: 1715 NPNTIYEVSITAIYPDESESDDLIGSERTLPILTTQA-PKSGPRNLQVYNATSNSLTVKW 1773
Query: 474 KEIPKSERKGIICNYTIFYQAEGGKGFSKTVNSSILQYG--LESLKRKTSYIVQV 526
P S R + Y I YQ G+G +T Q L+ LK T Y + V
Sbjct: 1774 D--PASGR---VQKYRITYQPSTGEGNEQTTTIGGRQNSVVLQKLKPDTPYTITV 1823
Score = 43.5 bits (101), Expect = 7e-04
Identities = 61/267 (22%), Positives = 102/267 (38%), Gaps = 34/267 (12%)
Query: 277 RPVRLLWKKARGAPVLEKTLGYNIWYYPESNTNLTE----TMNTTNQQLELHLGGESFWV 332
R R+ W P + Y + YYP S E M T+ +L E + V
Sbjct: 1399 RSFRVSW-----TPPSDSVDRYKVEYYPVSGGKRQEFYVSRMETSTVLKDLKPETE-YVV 1452
Query: 333 SMIS-----YNSLGKSPVATLRIPAIQEKSFQCIEVMQACVAEDQLVVKWQSSALDVNTW 387
++ S Y+ K TL +P + + V + V+WQ +
Sbjct: 1453 NVYSVVEDEYSEPLKGTEKTLPVPVVSLNIYD--------VGPTTMHVQWQPVG-GATGY 1503
Query: 388 MIEWFPDVDSEPTTLSWESVSQATNWTIQQDKLKPFWCYNISVYPMLHDKVGEPYSIQAY 447
++ + P D+EPT + N +Q L P Y ++V +LHD EP +++
Sbjct: 1504 ILSYKPVKDTEPTRPKEVRLGPTVN-DMQLTDLVPNTEYAVTVQAVLHDLTSEPVTVREV 1562
Query: 448 AKEGVPSEGP-ETKVENIGVKTVTITWKEIPKSERKGIICNYTIFYQAEGGKGFSKTVNS 506
+P P + K+ ++ T+ + W+ +P RK Y + Y+ V+
Sbjct: 1563 T---LPLPRPQDLKLRDVTHSTMNVFWEPVPGKVRK-----YIVRYKTPEEDVKEVEVDR 1614
Query: 507 SILQYGLESLKRKTSYIVQVMASTSAG 533
S L+ L +T Y V V A G
Sbjct: 1615 SETSTSLKDLFSQTLYTVSVSAVHDEG 1641
Score = 30.4 bits (67), Expect = 6.4
Identities = 39/170 (22%), Positives = 59/170 (34%), Gaps = 13/170 (7%)
Query: 375 VKWQSSALDVNTWMIEWFPDVDSEPTTLSWESVSQATNWTIQQDKLKPFWCYNISVYPML 434
V W S V + I + P +EP V + T++T+ L P Y+++VY
Sbjct: 2134 VSWDPSPSPVLGYKIVYKPVGSNEPMEAF---VGEMTSYTLHN--LNPSTTYDVNVYAQY 2188
Query: 435 HDKVGEPYSIQAYAKEGVPSEGPETKVENIGVKTVTITWKEIPKSERKGIICNYTIFYQA 494
+ P + Q + + K IG T + W S + A
Sbjct: 2189 DSGLSVPLTDQGTT---LYLNVTDLKTYQIGWDTFCVKW-----SPHRAATSYRLKLSPA 2240
Query: 495 EGGKGFSKTVNSSILQYGLESLKRKTSYIVQVMASTSAGGTNGTSINFKT 544
+G +G TV S + L T Y V V T G S+ T
Sbjct: 2241 DGTRGQEITVRGSETSHCFTGLSPDTDYGVTVFVQTPNLEGPGVSVKEHT 2290
>gi|75709184 contactin 3 [Homo sapiens]
Length = 1028
Score = 52.8 bits (125), Expect = 1e-06
Identities = 87/416 (20%), Positives = 157/416 (37%), Gaps = 45/416 (10%)
Query: 156 PPKIFRVKPVLGIKRMIQIEWIKPELAPVSSDLKYTLRFRTVNSTSWMEVNFAKNRKD-K 214
PP+ +V + + + K +PV S Y+++ RT S W V D K
Sbjct: 600 PPENVKVDEITDTTAQLSWKEGKDNHSPVIS---YSIQARTPFSVGWQTVTTVPEVIDGK 656
Query: 215 NQTYNLTGLQPFTEYVIALRCAVKESKFWSDWSQEKMGMTEEEAPCGLELWRVLKPAEAD 274
T + L P+ EY + + K EK+ TEE P + P+E +
Sbjct: 657 THTATVVELNPWVEYEFRVVASNKIGGGEPSLPSEKV-RTEEAVP-------EVPPSEVN 708
Query: 275 G----RRPVRLLWKKARGAPVLEKTLGYNIWYYPESNTNLTETMNTTNQQLELHLGGES- 329
G R + + W + GY + + P T +T+ T+ ES
Sbjct: 709 GGGGSRSELVITWDPVPEELQNGEGFGYVVAFRPLGVTTWIQTVVTSPDTPRYVFRNESI 768
Query: 330 -----FWVSMISYNSLGKSPVA--TLRIPAIQEKSFQCIEVMQACVAEDQLVVKWQSSAL 382
+ V + YN+ G+ P + T A +E + +V ++ ++ V W +
Sbjct: 769 VPYSPYEVKVGVYNNKGEGPFSPVTTVFSAEEEPTVAPSQVSANSLSSSEIEVSWNTIPW 828
Query: 383 DVNT-----WMIEWFPDVDSEPTTLSWESVSQATNWTIQQDKLKPFWCYNISVYPMLHDK 437
++ + + ++ E ++ + T+ ++ LK Y +V
Sbjct: 829 KLSNGHLLGYEVRYWNGGGKEESSSKMKVAGNETSARLRG--LKSNLAYYTAVRAYNSAG 886
Query: 438 VGEPYS--IQAYAKEGVPSEGPETKVENIGVKTVTITWKEIPKSERKGIICNYTIFYQAE 495
G P+S + K+ PS+ P V N V + W+++ E + + Y +FY+
Sbjct: 887 AG-PFSATVNVTTKKTPPSQPPGNVVWNATDTKVLLNWEQVKAMENESEVTGYKVFYRT- 944
Query: 496 GGKGFSKTVNSSILQYGLES----LKRKTSYIVQVMASTSAG-GTNGTSINFKTLS 546
S N +L S L K YI++V A+T G GT+ I ++
Sbjct: 945 -----SSQNNVQVLNTNKTSAELVLPIKEDYIIEVKATTDGGDGTSSEQIRIPRIT 995
>gi|4504647 interleukin 13 receptor, alpha 1 precursor [Homo
sapiens]
Length = 427
Score = 49.3 bits (116), Expect = 1e-05
Identities = 46/208 (22%), Positives = 88/208 (42%), Gaps = 24/208 (11%)
Query: 60 ISCVYYYRKNLTCTWSPGKETS-YTQYTVKRTYAFGEKHDNCTTNSSTSENRASCSFFLP 118
+ C+++ + C+W PG+ TS T YT+ + EK C N CSF L
Sbjct: 132 LQCIWHNLSYMKCSWLPGRNTSPDTNYTLYYWHRSLEKIHQC-ENIFREGQYFGCSFDLT 190
Query: 119 RI--TIPDNYTIEVEAENGDGVIKSHMTYWRLENIAKTEPPKIFRVKPVLGIKRMIQIEW 176
++ + + +++++ ++ G IK L + K +PP +K + + ++W
Sbjct: 191 KVKDSSFEQHSVQIMVKDNAGKIKPSFNIVPLTSRVKPDPP---HIKNLSFHNDDLYVQW 247
Query: 177 IKPELAPVSSDLKYTLRFRTVNSTSWMEVNFAKNRKDKNQTYN----------LTGLQPF 226
P+ +S L Y + + T V + + K +N + + G+ P
Sbjct: 248 ENPQNF-ISRCLFYEVEVNN-SQTETHNVFYVQEAKCENPEFERNVENTSCFMVPGVLPD 305
Query: 227 TEYVIALR-----CAVKESKFWSDWSQE 249
T + +R ++ K WS+WSQE
Sbjct: 306 TLNTVRIRVKTNKLCYEDDKLWSNWSQE 333
>gi|55743096 collagen, type XIV, alpha 1 [Homo sapiens]
Length = 1796
Score = 48.1 bits (113), Expect = 3e-05
Identities = 94/377 (24%), Positives = 150/377 (39%), Gaps = 49/377 (12%)
Query: 198 NSTSWMEVNFAKNRKDKNQTYNLTGLQPFTEYVIALRCAVKESKFWSDWSQEKMGM-TEE 256
N+ E+N + D T+ L GL P TEY IA+ E + S+ G+ T E
Sbjct: 570 NNADGTEINEVE--VDPITTFPLKGLTPLTEYTIAIFSIYDEGQ-----SEPLTGVFTTE 622
Query: 257 EAPCG--LELWRVLKPAEADGRRPV-------RLLWKKARGAPVLEKTLGYNIWYYPESN 307
E P LE+ V + P+ +L+W G E L E +
Sbjct: 623 EVPAQQYLEIDEVTTDSFRVTWHPLSADEGLHKLMWIPVYGGKTEEVVL------KEEQD 676
Query: 308 TNLTETMNTTNQQLELHL------GGESFWVSMI--SYNSLGKSPVATLRIPAIQEKSFQ 359
+++ E + + E+ L G ES V+ + + +S P T+ +P S
Sbjct: 677 SHVIEGLE-PGTEYEVSLLAVLDDGSESEVVTAVGTTLDSFWTEPATTI-VPTTSVTSVF 734
Query: 360 CIEVMQACVAED---QLVVKWQSSALDVNTWMIEWF-PDVDSEPTTLSWESVSQATNWTI 415
+ V ++ L VKW S DV + + + D E + V + N +
Sbjct: 735 QTGIRNLVVGDETTSSLRVKWDISDSDVQQFRVTYMTAQGDPEEEVIGTVMVPGSQN-NL 793
Query: 416 QQDKLKPFWCYNISVYPMLHDKVGEPYSIQAYAKEGVPSEGPET-KVENIGVKTVTITWK 474
L P Y ++V P+ D GE S+ A K +PS GP+ +V + ITW
Sbjct: 794 LLKPLLPDTEYKVTVTPIYTD--GEGVSVSAPGKT-LPSSGPQNLRVSEEWYNRLRITW- 849
Query: 475 EIPKSERKGIICNYTIFYQ--AEGGKGFSKTVNSSILQYGLESLKRKTSYIVQVMASTSA 532
+ P S KG Y I Y+ + G V + I + +L Y V++ AS ++
Sbjct: 850 DPPSSPVKG----YRIVYKPVSVPGPTLETFVGADINTILITNLLSGMDYNVKIFASQAS 905
Query: 533 GGTNGTSINFKTLSFSV 549
G ++ + KTL V
Sbjct: 906 GFSDALTGMVKTLFLGV 922
Score = 30.0 bits (66), Expect = 8.4
Identities = 20/88 (22%), Positives = 39/88 (44%), Gaps = 9/88 (10%)
Query: 456 GPETKV--ENIGVKTVTITWKEIPKSERKGIICNYTIFYQAEGGKGFSKTVNSSILQYGL 513
GP T++ + ++ + W P + K + ++Y GGK V+ ++ L
Sbjct: 354 GPPTELITSEVTARSFMVNWTHAPGNVEKYRV----VYYPTRGGKPDEVVVDGTVSSTVL 409
Query: 514 ESLKRKTSY---IVQVMASTSAGGTNGT 538
++L T Y + + A T++ G GT
Sbjct: 410 KNLMSLTEYQIAVFAIYAHTASEGLRGT 437
>gi|218505839 interleukin 11 receptor, alpha isoform 1 precursor
[Homo sapiens]
Length = 422
Score = 47.8 bits (112), Expect = 4e-05
Identities = 55/216 (25%), Positives = 84/216 (38%), Gaps = 32/216 (14%)
Query: 54 PAKPENISCVYYYRKNLTCTWSP----GKETSY-TQYTVKRTYAFGEKHDNCTTN--SST 106
PA+P +SC +N +CTWSP G T Y T Y K + + +T
Sbjct: 113 PARPV-VSCQAADYENFSCTWSPSQISGLPTRYLTSYRKKTVLGADSQRRSPSTGPWPCP 171
Query: 107 SENRASCSFFLPRITIPDNYTIEVEAENGDGVIKSHMTYWRLENIAKTEPPKIFRVKPVL 166
+ + + Y I V N G + + L++I + +PP+ RV+ V
Sbjct: 172 QDPLGAARCVVHGAEFWSQYRINVTEVNPLGA-STRLLDVSLQSILRPDPPQGLRVESVP 230
Query: 167 GIKRMIQIEWIKPELAPVSSD--LKYTLRFRTVNSTSWMEVNFAKNRKDKNQTYNLTGLQ 224
G R ++ W P P LK+ L++R +W V A GL+
Sbjct: 231 GYPRRLRASWTYPASWPCQPHFLLKFRLQYRPAQHPAWSTVEPA-------------GLE 277
Query: 225 P-FTEYVIALRCAVK-------ESKFWSDWSQEKMG 252
T+ V L AV+ ++ WS WS E G
Sbjct: 278 EVITDAVAGLPHAVRVSARDFLDAGTWSTWSPEAWG 313
>gi|22212922 interleukin 11 receptor, alpha isoform 2 precursor
[Homo sapiens]
Length = 390
Score = 47.8 bits (112), Expect = 4e-05
Identities = 55/216 (25%), Positives = 84/216 (38%), Gaps = 32/216 (14%)
Query: 54 PAKPENISCVYYYRKNLTCTWSP----GKETSY-TQYTVKRTYAFGEKHDNCTTN--SST 106
PA+P +SC +N +CTWSP G T Y T Y K + + +T
Sbjct: 113 PARPV-VSCQAADYENFSCTWSPSQISGLPTRYLTSYRKKTVLGADSQRRSPSTGPWPCP 171
Query: 107 SENRASCSFFLPRITIPDNYTIEVEAENGDGVIKSHMTYWRLENIAKTEPPKIFRVKPVL 166
+ + + Y I V N G + + L++I + +PP+ RV+ V
Sbjct: 172 QDPLGAARCVVHGAEFWSQYRINVTEVNPLGA-STRLLDVSLQSILRPDPPQGLRVESVP 230
Query: 167 GIKRMIQIEWIKPELAPVSSD--LKYTLRFRTVNSTSWMEVNFAKNRKDKNQTYNLTGLQ 224
G R ++ W P P LK+ L++R +W V A GL+
Sbjct: 231 GYPRRLRASWTYPASWPCQPHFLLKFRLQYRPAQHPAWSTVEPA-------------GLE 277
Query: 225 P-FTEYVIALRCAVK-------ESKFWSDWSQEKMG 252
T+ V L AV+ ++ WS WS E G
Sbjct: 278 EVITDAVAGLPHAVRVSARDFLDAGTWSTWSPEAWG 313
Database: hs.faa
Posted date: Aug 4, 2009 4:42 PM
Number of letters in database: 18,247,518
Number of sequences in database: 37,866
Lambda K H
0.316 0.132 0.411
Gapped
Lambda K H
0.267 0.0410 0.140
Matrix: BLOSUM62
Gap Penalties: Existence: 11, Extension: 1
Number of Hits to DB: 31,955,724
Number of Sequences: 37866
Number of extensions: 1517478
Number of successful extensions: 4066
Number of sequences better than 10.0: 30
Number of HSP's better than 10.0 without gapping: 19
Number of HSP's successfully gapped in prelim test: 113
Number of HSP's that attempted gapping in prelim test: 3474
Number of HSP's gapped (non-prelim): 586
length of query: 764
length of database: 18,247,518
effective HSP length: 110
effective length of query: 654
effective length of database: 14,082,258
effective search space: 9209796732
effective search space used: 9209796732
T: 11
A: 40
X1: 16 ( 7.3 bits)
X2: 38 (14.6 bits)
X3: 64 (24.7 bits)
S1: 41 (21.6 bits)
S2: 66 (30.0 bits)
Search results were obtained with NCBI BLAST and RefSeq entries.
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Guide to the Human Genome
Copyright © 2010 by Stewart Scherer. All rights reserved.