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Search of human proteins with 224591406
BLASTP 2.2.11 [Jun-05-2005]
Reference: Altschul, Stephen F., Thomas L. Madden, Alejandro A. Schaffer,
Jinghui Zhang, Zheng Zhang, Webb Miller, and David J. Lipman (1997),
"Gapped BLAST and PSI-BLAST: a new generation of protein database search
programs", Nucleic Acids Res. 25:3389-3402.
Query= gi|224591406 SH2 domain containing 4B isoform 1 [Homo sapiens]
(357 letters)
Database: hs.faa
37,866 sequences; 18,247,518 total letters
Searching..................................................done
Score E
Sequences producing significant alignments: (bits) Value
gi|224591406 SH2 domain containing 4B isoform 1 [Homo sapiens] 730 0.0
gi|224591408 SH2 domain containing 4B isoform 2 [Homo sapiens] 602 e-172
gi|21361891 SH2 domain containing 4A [Homo sapiens] 221 6e-58
gi|148746195 trichohyalin [Homo sapiens] 72 1e-12
gi|44680105 caldesmon 1 isoform 1 [Homo sapiens] 70 4e-12
gi|239745079 PREDICTED: Putative golgin subfamily A member 6-lik... 64 3e-10
gi|239745153 PREDICTED: similar to Putative golgin subfamily A m... 62 6e-10
gi|239745127 PREDICTED: similar to Putative golgin subfamily A m... 62 6e-10
gi|102467235 inner centromere protein antigens 135/155kDa isofor... 62 6e-10
gi|102467242 inner centromere protein antigens 135/155kDa isofor... 62 6e-10
gi|222418637 golgi autoantigen, golgin subfamily a-like [Homo sa... 62 8e-10
gi|239745095 PREDICTED: hypothetical protein LOC645202 [Homo sap... 61 2e-09
gi|222446603 golgi autoantigen, golgin subfamily a-like [Homo sa... 60 3e-09
gi|239756241 PREDICTED: golgi autoantigen, golgin subfamily a-li... 59 9e-09
gi|221219020 NYD-SP11 protein [Homo sapiens] 58 1e-08
gi|169218106 PREDICTED: hypothetical protein, partial [Homo sapi... 58 1e-08
gi|239735580 TRAF2 and NCK interacting kinase isoform 2 [Homo sa... 58 1e-08
gi|55741807 TRAF2 and NCK interacting kinase isoform 1 [Homo sap... 58 1e-08
gi|225579095 S-phase cyclin A-associated protein in the ER isofo... 57 3e-08
gi|225579092 S-phase cyclin A-associated protein in the ER isofo... 57 3e-08
gi|239735588 TRAF2 and NCK interacting kinase isoform 6 [Homo sa... 56 4e-08
gi|239735586 TRAF2 and NCK interacting kinase isoform 5 [Homo sa... 56 4e-08
gi|41322923 plectin 1 isoform 11 [Homo sapiens] 55 7e-08
gi|41322914 plectin 1 isoform 10 [Homo sapiens] 55 7e-08
gi|41322919 plectin 1 isoform 8 [Homo sapiens] 55 7e-08
gi|41322910 plectin 1 isoform 7 [Homo sapiens] 55 7e-08
gi|41322916 plectin 1 isoform 6 [Homo sapiens] 55 7e-08
gi|41322908 plectin 1 isoform 3 [Homo sapiens] 55 7e-08
gi|41322912 plectin 1 isoform 2 [Homo sapiens] 55 7e-08
gi|47607492 plectin 1 isoform 1 [Homo sapiens] 55 7e-08
>gi|224591406 SH2 domain containing 4B isoform 1 [Homo sapiens]
Length = 357
Score = 730 bits (1884), Expect = 0.0
Identities = 357/357 (100%), Positives = 357/357 (100%)
Query: 1 MLQQILHDMYIDPELLAELSDVQKHILFYKMREEQLRRWKERETWEALAQDEGLRPPKTK 60
MLQQILHDMYIDPELLAELSDVQKHILFYKMREEQLRRWKERETWEALAQDEGLRPPKTK
Sbjct: 1 MLQQILHDMYIDPELLAELSDVQKHILFYKMREEQLRRWKERETWEALAQDEGLRPPKTK 60
Query: 61 RAASDKHIQWLLGADGEVWVWIMGEGPGDKPYEEISEELIAERARLQAQREAEELWRQKE 120
RAASDKHIQWLLGADGEVWVWIMGEGPGDKPYEEISEELIAERARLQAQREAEELWRQKE
Sbjct: 61 RAASDKHIQWLLGADGEVWVWIMGEGPGDKPYEEISEELIAERARLQAQREAEELWRQKE 120
Query: 121 AEITKKFRDALANEKARILAEKWKVEMEDRKAAKVLEERIHEEFKRKEEEERKRGEEQIR 180
AEITKKFRDALANEKARILAEKWKVEMEDRKAAKVLEERIHEEFKRKEEEERKRGEEQIR
Sbjct: 121 AEITKKFRDALANEKARILAEKWKVEMEDRKAAKVLEERIHEEFKRKEEEERKRGEEQIR 180
Query: 181 LQEEQRAKELYWTLKQAQLHCQASEKEEREWEEQLRRSKAADEERSRRAQRARDEYRHHS 240
LQEEQRAKELYWTLKQAQLHCQASEKEEREWEEQLRRSKAADEERSRRAQRARDEYRHHS
Sbjct: 181 LQEEQRAKELYWTLKQAQLHCQASEKEEREWEEQLRRSKAADEERSRRAQRARDEYRHHS 240
Query: 241 LRAIQKGTVAGLSSMFRELGQSHEQEARLYHHLPDPGLPQPLALPVRTWERPLRPVSRDV 300
LRAIQKGTVAGLSSMFRELGQSHEQEARLYHHLPDPGLPQPLALPVRTWERPLRPVSRDV
Sbjct: 241 LRAIQKGTVAGLSSMFRELGQSHEQEARLYHHLPDPGLPQPLALPVRTWERPLRPVSRDV 300
Query: 301 IVRWFKEEQLPRRAGFERNTKFIAPWFHGGNYHCFRRRVTSGTLRTEGQPTRLPSVV 357
IVRWFKEEQLPRRAGFERNTKFIAPWFHGGNYHCFRRRVTSGTLRTEGQPTRLPSVV
Sbjct: 301 IVRWFKEEQLPRRAGFERNTKFIAPWFHGGNYHCFRRRVTSGTLRTEGQPTRLPSVV 357
>gi|224591408 SH2 domain containing 4B isoform 2 [Homo sapiens]
Length = 309
Score = 602 bits (1553), Expect = e-172
Identities = 300/311 (96%), Positives = 301/311 (96%), Gaps = 4/311 (1%)
Query: 48 LAQDEGLRPPKTKRAASDKHIQWLLGADGEVWVWIMGEGPGDKPYEEISEELIAERARLQ 107
L +D G P AASDKHIQWLLGADGEVWVWIMGEGPGDKPYEEISEELIAERARLQ
Sbjct: 2 LPEDSGGSPDA---AASDKHIQWLLGADGEVWVWIMGEGPGDKPYEEISEELIAERARLQ 58
Query: 108 AQREAEELWRQKEAEITKKFRDALANEKARILAEKWKVEMEDRKAAKVLEERIHEEFKRK 167
AQREAEELWRQKEAEITKKFRDALANEKARILAEKWKVEMEDRKAAKVLEERIHEEFKRK
Sbjct: 59 AQREAEELWRQKEAEITKKFRDALANEKARILAEKWKVEMEDRKAAKVLEERIHEEFKRK 118
Query: 168 EEEERKRGEEQIRLQEEQRAKELYWTLKQAQLHCQASEKEEREWEEQLRRSKAADEERSR 227
EEEERKRGEEQIRLQEEQRAKELYWTLKQAQLHCQASEKEEREWEEQLRRSKAADEERSR
Sbjct: 119 EEEERKRGEEQIRLQEEQRAKELYWTLKQAQLHCQASEKEEREWEEQLRRSKAADEERSR 178
Query: 228 RAQRARDEYRHHSLRAIQKGTVAGLSSMFRELGQSHEQEARLYHHLPDPGLPQPLALPV- 286
RAQRARDEYRHHSLRAIQKGTVAGLSSMFRELGQSHEQEARLYHHLPDPGLPQPLALPV
Sbjct: 179 RAQRARDEYRHHSLRAIQKGTVAGLSSMFRELGQSHEQEARLYHHLPDPGLPQPLALPVS 238
Query: 287 RTWERPLRPVSRDVIVRWFKEEQLPRRAGFERNTKFIAPWFHGGNYHCFRRRVTSGTLRT 346
RTWERPLRPVSRDVIVRWFKEEQLPRRAGFERNTKFIAPWFHGGNYHCFRRRVTSGTLRT
Sbjct: 239 RTWERPLRPVSRDVIVRWFKEEQLPRRAGFERNTKFIAPWFHGGNYHCFRRRVTSGTLRT 298
Query: 347 EGQPTRLPSVV 357
EGQPTRLPSVV
Sbjct: 299 EGQPTRLPSVV 309
>gi|21361891 SH2 domain containing 4A [Homo sapiens]
Length = 454
Score = 221 bits (564), Expect = 6e-58
Identities = 148/371 (39%), Positives = 206/371 (55%), Gaps = 63/371 (16%)
Query: 1 MLQQILHDMYIDPELLAELSDVQKHILFYKMREEQLRRWKERETWEALAQDEGLRPPKTK 60
ML+QIL +MYIDP+LLAELS+ QK ILF+KMREEQ+RRWKERE A+ + E L
Sbjct: 1 MLKQILSEMYIDPDLLAELSEEQKQILFFKMREEQIRRWKEREA--AMERKESLPVKPRP 58
Query: 61 RAASDKHIQWLLGADGEVWVWIMGEGPGDKPYEEISEELIAERARLQAQREAEELWRQKE 120
+ + K + W LGAD EVWVW+MGE DKPY+ + E+IAERARL+A++EAEE +
Sbjct: 59 KKENGKSVHWKLGADKEVWVWVMGEHHLDKPYDVLCNEIIAERARLKAEQEAEEPRKTHS 118
Query: 121 AEIT------KKFRDALANEKARI------LAEKWKVEMEDRKAAKVLEERIHE------ 162
E T ++ D A + + +AEK ++E R A + EE+I
Sbjct: 119 EEFTNSLKTKSQYHDLQAPDNQQTKDIWKKVAEKEELEQGSRPAPTLEEEKIRSLSSSSR 178
Query: 163 ----------------EFKRKEEEERKRGEEQIRLQEEQRAKELYWTLKQAQLHCQASEK 206
F +K+E +K+ +E+I EE+R K++ C+ S K
Sbjct: 179 NIQQMLADSINRMKAYAFHQKKESMKKKQDEEINQIEEERTKQI----------CK-SWK 227
Query: 207 EEREWEEQLRRSKAADEERSRRAQRARDEYRHHSLRAIQKGTVAGLSSMFRELGQSHEQE 266
E+ EW+ LR+SKAADE+R A++AR++Y+ SL A QKG E QS +
Sbjct: 228 EDSEWQASLRKSKAADEKRRSLAKQAREDYKRLSLGA-QKGRGG-------ERLQSPLRV 279
Query: 267 ARLYHHLPDPGLPQPL---ALPVRTWE-----RPLRPVSRDVIVRWFKEEQLPRRAGFER 318
+ P P PQ L A P + R L +++ I+RWFKEEQLP RAG+++
Sbjct: 280 PQKPERPPLPPKPQFLNSGAYPQKPLRNQGVVRTLSSSAQEDIIRWFKEEQLPLRAGYQK 339
Query: 319 NTKFIAPWFHG 329
+ IAPWFHG
Sbjct: 340 TSDTIAPWFHG 350
>gi|148746195 trichohyalin [Homo sapiens]
Length = 1943
Score = 71.6 bits (174), Expect = 1e-12
Identities = 78/334 (23%), Positives = 148/334 (44%), Gaps = 45/334 (13%)
Query: 7 HDMYIDPELLAEL-----------SDVQKHILFYKMREEQLRRWKERETWEALAQDEGLR 55
H +Y P L +L ++Q+ + R+EQ R+++E E + +++ LR
Sbjct: 887 HTLYAKPALQEQLRKEQQLLQEEEEELQREEREKRRRQEQERQYREEEQLQQ-EEEQLLR 945
Query: 56 PPKTKRAASDKHIQWLLGADGEVWVWIMGEGPGDKPYEEISEELIAERARLQAQREAEEL 115
+ KR ++ Q+ DK ++ E+L+ E + ++E E+
Sbjct: 946 EEREKRRRQERERQYRK----------------DKKLQQKEEQLLGEEPEKRRRQEREKK 989
Query: 116 WRQKEAEITKKFRDALANEKARILAEKWKVEMEDRKAAKVLEERIHEEFKRK----EEEE 171
+R++E E+ ++ L E+ + ++W+ + + + EE++ E + K E E
Sbjct: 990 YREEE-ELQQEEEQLLREEREKRRRQEWERQYRKKDELQQEEEQLLREEREKRRLQERER 1048
Query: 172 RKRGEEQIRLQEEQRAKELYWTLKQAQLHCQASEKEE-REWEEQLRRSKAADEERSRRAQ 230
+ R EE+++ +EEQ E T ++ +L Q ++EE ++ EEQL R + R R +
Sbjct: 1049 QYREEEELQQEEEQLLGEERETRRRQELERQYRKEEELQQEEEQLLREEPEKRRRQERER 1108
Query: 231 RARDE-----YRHHSLR-AIQKGTVAGLSSMFRELGQSHEQEARLYHHLPDPGLPQPLAL 284
+ R+E LR +K L +RE + ++E +L P+ Q L
Sbjct: 1109 QCREEEELQQEEEQLLREEREKRRRQELERQYREEEEVQQEEEQLLREEPEKRRRQELER 1168
Query: 285 PVRTWERPLRPVSRDVIVRWFKEEQLPRRAGFER 318
R E L+ ++ +EEQ RR ER
Sbjct: 1169 QYRE-EEELQQEEEQLL----REEQEKRRQERER 1197
Score = 67.0 bits (162), Expect = 2e-11
Identities = 55/211 (26%), Positives = 101/211 (47%), Gaps = 23/211 (10%)
Query: 30 KMREEQLRRWKERETWEALAQDEGLRPPKTKRAASDKHIQWLLGADGEVWVWIMGEGPGD 89
K+ EE+ R +ER + + E R + KR ++ +Q L ++ ++
Sbjct: 490 KLEEEERREQQERREQQLRREQEERREQRLKRQEEEERLQQRLRSEQQL----------R 539
Query: 90 KPYEEISEELIA--ERARLQAQREAEELWRQKEAEITKKFRDALANEKARILAEKWKVEM 147
+ EE E+L+ E RL+ +R + L R++E RD L + ++ K E
Sbjct: 540 REQEERREQLLKREEEKRLEQERREQRLKREQEER-----RDQLLKREEERRQQRLKREQ 594
Query: 148 EDRKAAKVLEERI-HEEFKRKEEEERKRGEEQIRLQEEQRAKELYWTLKQAQLHCQASEK 206
E+R LE+R+ EE +R E+EER+ + EE+R ++L + +Q + Q +
Sbjct: 595 EER-----LEQRLKREEVERLEQEERREQRLKREEPEEERRQQLLKSEEQEERRQQQLRR 649
Query: 207 EEREWEEQLRRSKAADEERSRRAQRARDEYR 237
E++E EQ + + +E +R +R +E R
Sbjct: 650 EQQERREQRLKREEEEERLEQRLKREHEEER 680
Score = 63.5 bits (153), Expect = 3e-10
Identities = 73/302 (24%), Positives = 137/302 (45%), Gaps = 34/302 (11%)
Query: 32 REEQLRRWKERETWEALAQDEGLRPPKTKRAASDKHIQWLLGADGEVWVWIMGEGPGDKP 91
RE+QLRR ++ + L +++ LR + R + L + E ++
Sbjct: 385 REQQLRREQQLRREQQLRREQQLRREQQLRREQQLRREQQLRREQE-----------EER 433
Query: 92 YEEISEELIAERARLQAQREAEELWRQKEAEITK----KFRDALANEKARILAEKW-KVE 146
+E+ E+ E+ RL+ ++E W ++E E + + + L ++ E+W K+E
Sbjct: 434 HEQKHEQERREQ-RLKREQEERRDWLKREEETERHEQERRKQQLKRDQEEERRERWLKLE 492
Query: 147 MEDRKAAKVLEERIHEEFKRKEEEER----KRGEEQIRLQEEQRAKELYWTLKQAQLHCQ 202
E+R+ +ER ++ +R++EE R KR EE+ RLQ+ R+++ ++ +
Sbjct: 493 EEERREQ---QERREQQLRREQEERREQRLKRQEEEERLQQRLRSEQQLRREQEERREQL 549
Query: 203 ASEKEEREWEEQLRRSKAADEERSRRAQ--RARDEYRHHSLRAIQKGTVAGLSSMFRE-- 258
+EE+ E++ R + E+ RR Q + +E R L+ Q+ + + RE
Sbjct: 550 LKREEEKRLEQERREQRLKREQEERRDQLLKREEERRQQRLKREQEERLE--QRLKREEV 607
Query: 259 --LGQSHEQEARLYHHLPDPGLPQPLALPVRTWERPLRPVSRDVIVRWFKEEQLPRRAGF 316
L Q +E RL P+ Q L ER + + R+ R +E++L R
Sbjct: 608 ERLEQEERREQRLKREEPEEERRQQLLKSEEQEERRQQQLRREQQER--REQRLKREEEE 665
Query: 317 ER 318
ER
Sbjct: 666 ER 667
Score = 62.8 bits (151), Expect = 5e-10
Identities = 71/310 (22%), Positives = 141/310 (45%), Gaps = 39/310 (12%)
Query: 3 QQILHDMYIDPELLAELSDVQKHILFYKMREEQLRRWKERETWEALAQDEGLRPPKTKRA 62
+Q LH D + L E +++ ++R ++ R+++E E +++ LR + R
Sbjct: 1633 EQQLHRQERDRKFLEEEPQLRRQEREQQLRHDRDRKFREEEQLLQEGEEQQLRRQERDRK 1692
Query: 63 ASDKHIQWLLGADGEVWVWIMGEGPGDKPYEEISEELIAERARLQAQREAEELWRQKEAE 122
++ Q L ++ E + + E E +L+ + E E+L RQ+
Sbjct: 1693 FREEEQQ--LRRQERERKFLQEE---QQLRRQELERKFREEEQLRQETEQEQLRRQE--- 1744
Query: 123 ITKKFRDALANEKARILAEKWKVEMEDR-----KAAKVLEERIHEEFKRKEEEERKRGEE 177
++R L E+ R E+ ++ ++R + ++ +ER ++ + +E + + R EE
Sbjct: 1745 ---RYRKILEEEQLRPEREEQQLRRQERDRKFREEEQLRQEREEQQLRSQESDRKFREEE 1801
Query: 178 QIR-------LQEEQRAKELYWTLKQAQLHCQASEKEEREWEEQLRRSKA----ADEERS 226
Q+R L+ +QR + W +Q QL E+E+R +E+ R+ +A A +E+S
Sbjct: 1802 QLRQEREEQQLRPQQRDGKYRWEEEQLQLE----EQEQRLRQERDRQYRAEEQFATQEKS 1857
Query: 227 RR--------AQRARDEYRHHSLRAIQKGTVAGLSSMFRELGQSHEQEARLYHHLPDPGL 278
RR ++ R + R LR R++G+ QE + + L +PG
Sbjct: 1858 RREEQELWQEEEQKRRQERERKLREEHIRRQQKEEQRHRQVGEIKSQEGKGHGRLLEPGT 1917
Query: 279 PQPLALPVRT 288
Q ++PVR+
Sbjct: 1918 HQFASVPVRS 1927
Score = 55.1 bits (131), Expect = 1e-07
Identities = 72/314 (22%), Positives = 142/314 (45%), Gaps = 43/314 (13%)
Query: 33 EEQLRRWKERETWEALAQDEGLR---PPKTKRAASDKHIQWLLGADGEVWVWIMGEGPGD 89
EE+L+R K ++ + Q L+ P+ + A D + + G + E + + D
Sbjct: 1202 EEELQRQKRKQRYRDEDQRSDLKWQWEPEKENAVRDNKV-YCKGRENEQFRQLEDSQLRD 1260
Query: 90 KPYEEISEELIAE---RARLQAQR----------EAEELWRQKEAEITKKFRDALANEKA 136
+ ++ + L+ E R R Q +R E E+L R+++ E K RD + E+
Sbjct: 1261 RQSQQDLQHLLGEQQERDREQERRRWQQRDRHFPEEEQLEREEQKEA--KRRDRKSQEEK 1318
Query: 137 RILAE-------KWKVEMEDRKAAKVLEERIHEEFKRKEEEERKRGEEQIR--------L 181
++L E + + + + R+ ++L+ER + R++E +RK EE++R L
Sbjct: 1319 QLLREEREEKRRRQETDRKFREEEQLLQEREEQPL-RRQERDRKFREEELRHQEQGRKFL 1377
Query: 182 QEEQR----AKELYWTLKQAQLHCQASEKEEREWEEQLRRSKAADEERSRRAQRARDEYR 237
+EEQR +E + ++ QL CQ E++ R+ ++ R + R R ++ R+E +
Sbjct: 1378 EEEQRLRRQERERKFLKEEQQLRCQEREQQLRQDRDRKFREEEQQLSRQERDRKFREEEQ 1437
Query: 238 HHSLRAIQKGTVAGLSSMFRELGQSHEQEARLYHHLPDPGL-PQPLALPVRTWERPLRPV 296
+ ++ + + +E + +E +L + L Q E+ LR
Sbjct: 1438 QVRRQERERKFLEEEQQLRQERHRKFREEEQLLQEREEQQLHRQERDRKFLEEEQQLRRQ 1497
Query: 297 SRDVIVRWFKEEQL 310
RD R F+E++L
Sbjct: 1498 ERD---RKFREQEL 1508
Score = 54.7 bits (130), Expect = 1e-07
Identities = 67/256 (26%), Positives = 119/256 (46%), Gaps = 39/256 (15%)
Query: 30 KMREEQLRRWKERETWEALAQDEGLRPPKTKRAASDKHIQWLLGADGEVWVWIMGEGPGD 89
K +E+ R W +RE E ++ R + KR ++ + W+ E
Sbjct: 448 KREQEERRDWLKREE-ETERHEQERRKQQLKRDQEEERRER----------WLKLEEEER 496
Query: 90 KPYEEISEELIAERARLQAQREAEELWRQKEAE-ITKKFRDALANEKARILAEKWKVEME 148
+ +E E+ + R Q +R + L RQ+E E + ++ R + ++ R E+ + ++
Sbjct: 497 REQQERREQQLR---REQEERREQRLKRQEEEERLQQRLR---SEQQLRREQEERREQLL 550
Query: 149 DRKAAKVLE-ERIHEEFKRKEEEER----KRGEE--QIRLQEEQR-------AKELYWTL 194
R+ K LE ER + KR++EE R KR EE Q RL+ EQ +E L
Sbjct: 551 KREEEKRLEQERREQRLKREQEERRDQLLKREEERRQQRLKREQEERLEQRLKREEVERL 610
Query: 195 KQAQLHCQASEKEEREWE--EQLRRSKAADEERSRRAQRARDEYRHHSLRAIQKGTVAGL 252
+Q + Q ++EE E E +QL +S+ +E R ++ +R + E R L+ ++
Sbjct: 611 EQEERREQRLKREEPEEERRQQLLKSEEQEERRQQQLRREQQERREQRLKREEEE----- 665
Query: 253 SSMFRELGQSHEQEAR 268
+ + L + HE+E R
Sbjct: 666 ERLEQRLKREHEEERR 681
Score = 54.7 bits (130), Expect = 1e-07
Identities = 63/286 (22%), Positives = 128/286 (44%), Gaps = 47/286 (16%)
Query: 23 QKHILFYKMREEQLRRWKERETWEALAQDEGLRPPKTKRAASDKHIQWLLGADGEVWVWI 82
+K + F + E+ RR + ++ E +++GL+ + +R + ++ + W W
Sbjct: 828 EKELQFLEEEEQLQRRERAQQLQE---EEDGLQEDQERRRSQEQRRD-------QKWRWQ 877
Query: 83 MGEGPGDKPYE-----EISEELIAERARLQA-----QREAEELWRQKEAEITKKFRDALA 132
+ E + + + E+L E+ LQ QRE E R++E E + + L
Sbjct: 878 LEEERKRRRHTLYAKPALQEQLRKEQQLLQEEEEELQREEREKRRRQEQERQYREEEQLQ 937
Query: 133 NEKARILAEKWKVEM---------EDRKAAKVLEERIHEE---FKRKEEEERKRGEEQIR 180
E+ ++L E+ + +D+K + E+ + EE +R+E E++ R EE+++
Sbjct: 938 QEEEQLLREEREKRRRQERERQYRKDKKLQQKEEQLLGEEPEKRRRQEREKKYREEEELQ 997
Query: 181 LQEEQRAKELYWTLKQAQLHCQASEKEE-REWEEQLRRSKAADEERSRRAQRARDEYRHH 239
+EEQ +E ++ + Q +K+E ++ EEQL R +E RR Q +YR
Sbjct: 998 QEEEQLLREEREKRRRQEWERQYRKKDELQQEEEQLLR----EEREKRRLQERERQYREE 1053
Query: 240 SLRAIQKGTVAG----------LSSMFRELGQSHEQEARLYHHLPD 275
++ + G L +R+ + ++E +L P+
Sbjct: 1054 EELQQEEEQLLGEERETRRRQELERQYRKEEELQQEEEQLLREEPE 1099
Score = 54.7 bits (130), Expect = 1e-07
Identities = 57/230 (24%), Positives = 107/230 (46%), Gaps = 38/230 (16%)
Query: 31 MREEQLRRWKERETWEA-------LAQDEG--LRPPKTKRAASDKHIQWLLGADGEVWVW 81
+REE+ +R R+ WE L Q+E LR + KR ++ Q+
Sbjct: 1004 LREEREKR--RRQEWERQYRKKDELQQEEEQLLREEREKRRLQERERQYR---------- 1051
Query: 82 IMGEGPGDKPYEEISEELIAERARLQAQREAEELWRQKEAEITKKFRDALANEKARILAE 141
++ ++ E+L+ E + ++E E +R KE E+ ++ L E + +
Sbjct: 1052 ------EEEELQQEEEQLLGEERETRRRQELERQYR-KEEELQQEEEQLLREEPEKRRRQ 1104
Query: 142 KWKVEMEDRKAAKVLEERI----HEEFKRKEEEERKRGEEQIRLQEEQRAKELYWTLKQA 197
+ + + + + + EE++ E+ +R+E E + R EE+++ +EEQ +E ++
Sbjct: 1105 ERERQCREEEELQQEEEQLLREEREKRRRQELERQYREEEEVQQEEEQLLREEPEKRRRQ 1164
Query: 198 QLHCQASEKEE-REWEEQLRRSKAADEERSRRAQRARDEYRHHSLRAIQK 246
+L Q E+EE ++ EEQL R EE+ +R Q +YR QK
Sbjct: 1165 ELERQYREEEELQQEEEQLLR-----EEQEKRRQERERQYREEEELQRQK 1209
Score = 53.9 bits (128), Expect = 2e-07
Identities = 49/220 (22%), Positives = 100/220 (45%), Gaps = 15/220 (6%)
Query: 30 KMREEQLRRWKERETWEALAQDEGLRPPKT---KRAASDKHIQWLLGADGEVWVWIMGEG 86
+ EEQL+ K ET E +E LR + +R ++ Q V+ +
Sbjct: 187 RAEEEQLQSCKGHET-EEFPDEEQLRRRELLELRRKGREEKQQQRRERQDRVF-----QE 240
Query: 87 PGDKPYEEISEELIAERARLQAQREAEELWRQKEAEITKKFRDALANEKARILAEKWKVE 146
+K + + L E +LQ + + Q+E E +K E+ + E+ + E
Sbjct: 241 EEEKEWRKRETVLRKEEEKLQEEEPQRQRELQEEEEQLRKL------ERQELRRERQEEE 294
Query: 147 MEDRKAAKVLEERIHEEFKRKEEEERKRGEEQIRLQEEQRAKELYWTLKQAQLHCQASEK 206
+ ++ + + R +E +R+E++E +R +++ R Q+E+R ++ ++ + Q +
Sbjct: 295 QQQQRLRREQQLRRKQEEERREQQEERREQQERREQQEERREQQLRREQEERREQQLRRE 354
Query: 207 EEREWEEQLRRSKAADEERSRRAQRARDEYRHHSLRAIQK 246
+E E EQ R + +E R ++ +R + R LR Q+
Sbjct: 355 QEEERREQQLRREQEEERREQQLRREQQLRREQQLRREQQ 394
Score = 50.8 bits (120), Expect = 2e-06
Identities = 46/204 (22%), Positives = 99/204 (48%), Gaps = 25/204 (12%)
Query: 32 REEQLRRWKERETWEALAQDEGLRPPKTKRAASDKHIQWLLGADGEVWVWIMGEGPGDKP 91
RE+QLRR +E E E Q E R + +R ++ + L + E ++
Sbjct: 302 REQQLRRKQEEERRE---QQEERREQQERREQQEERREQQLRREQE-----------ERR 347
Query: 92 YEEISEELIAERARLQAQREAEELWRQKEAEITKKFRDALANEKARILAEKWKVEMEDRK 151
+++ E ER Q +RE EE R+++ ++ R E+ ++ + E + R+
Sbjct: 348 EQQLRREQEEERREQQLRREQEEERREQQLRREQQLR----REQQLRREQQLRREQQLRR 403
Query: 152 AAKVLEERIHEEFKRKEEEERKRGEEQIRLQEEQRAKELYWTLKQAQLHCQASEKEEREW 211
E+++ E + + E++ +R E+Q+R ++E+ E ++ + + ++E R+W
Sbjct: 404 -----EQQLRREQQLRREQQLRR-EQQLRREQEEERHEQKHEQERREQRLKREQEERRDW 457
Query: 212 EEQLRRSKAADEERSRRAQRARDE 235
++ ++ ++ER R+ Q RD+
Sbjct: 458 LKREEETERHEQER-RKQQLKRDQ 480
Score = 49.3 bits (116), Expect = 5e-06
Identities = 63/251 (25%), Positives = 114/251 (45%), Gaps = 31/251 (12%)
Query: 97 EELIAERARLQAQR-EAEELWRQKEAEITKKFRDALANEKA--------RILAEKWKVEM 147
E+L+ ER Q R E + + ++E ++ ++ RD E+ + L E+ ++
Sbjct: 1467 EQLLQEREEQQLHRQERDRKFLEEEQQLRRQERDRKFREQELRSQEPERKFLEEEQQLHR 1526
Query: 148 EDRKAAKVLEE----RIHEEFKRKEEEERK-RGEEQIRLQEEQRA-----KELYWTLKQA 197
+ R+ + EE R +R+++ +RK R EEQ+R + E++ ++ + L++
Sbjct: 1527 QQRQRKFLQEEQQLRRQERGQQRRQDRDRKFREEEQLRQEREEQQLSRQERDRKFRLEEQ 1586
Query: 198 QLHCQASEKEEREWEEQLRRSKAADEERSRRAQRARDEYRHHSLRAIQKGTVAGLSSMFR 257
++ Q E++ E E+QLRR + + R R ++ R++ + R Q+ F
Sbjct: 1587 KVRRQEQERKFMEDEQQLRRQEGQQQLRQERDRKFREDEQLLQEREEQQLHRQERDRKFL 1646
Query: 258 E-----LGQSHEQEARLYHHLPDPGLPQPLALPVRTWERPLRPVSRDVIVRWFKEEQLPR 312
E Q EQ+ R H D + L E+ LR RD R F+EE+
Sbjct: 1647 EEEPQLRRQEREQQLR---HDRDRKFREEEQLLQEGEEQQLRRQERD---RKFREEEQQL 1700
Query: 313 RAGFERNTKFI 323
R ER KF+
Sbjct: 1701 RRQ-ERERKFL 1710
Score = 48.9 bits (115), Expect = 7e-06
Identities = 56/264 (21%), Positives = 112/264 (42%), Gaps = 57/264 (21%)
Query: 32 REEQLRRWKERETW-----EALAQDEGLRPPKTKRAASDKHIQWLLGADGEVWVWIMGEG 86
+EE+ + W++RET E L ++E P+ +R ++ Q E+
Sbjct: 239 QEEEEKEWRKRETVLRKEEEKLQEEE----PQRQRELQEEEEQLRKLERQEL-------- 286
Query: 87 PGDKPYEEISEELIAERARLQAQREAEELWRQKEAEITKKFRDALANEKARILAEKWKVE 146
++ EE ++ + +L+ ++E E +Q+E ++ R+ + + L + +
Sbjct: 287 RRERQEEEQQQQRLRREQQLRRKQEEERREQQEERREQQERREQQEERREQQLRREQEER 346
Query: 147 MEDRKAAKVLEERIHEEFKRKEEEERK----------------------RGEEQIRLQEE 184
E + + EER ++ +R++EEER+ R E+Q+R +++
Sbjct: 347 REQQLRREQEEERREQQLRREQEEERREQQLRREQQLRREQQLRREQQLRREQQLRREQQ 406
Query: 185 QRAKELYWTLKQAQLHCQASEKEEREWEEQLRRSKAADEERSRRAQRARDEYRHHSLRAI 244
R ++ L++ Q + ++ RE EE+ K E R +R +R ++E R R
Sbjct: 407 LRREQ---QLRREQ-QLRREQQLRREQEEERHEQKHEQERREQRLKREQEERRDWLKR-- 460
Query: 245 QKGTVAGLSSMFRELGQSHEQEAR 268
E + HEQE R
Sbjct: 461 ------------EEETERHEQERR 472
Score = 48.5 bits (114), Expect = 9e-06
Identities = 53/229 (23%), Positives = 108/229 (47%), Gaps = 30/229 (13%)
Query: 33 EEQLRRWKERETWEALAQDEGLRPPKTKRAASDKHIQ-----WLLGADGEVWVWIMGEGP 87
E+QLRR +E + L ++E R + +R K Q LL + E +
Sbjct: 535 EQQLRREQEERREQLLKREEEKRLEQERREQRLKREQEERRDQLLKREEERRQQRLKREQ 594
Query: 88 GDKPYEEISEELIAERARLQAQREAEELWRQKEAEITKKFRDALANEKARILAEKWKVEM 147
++ + + E E RL+ + E+ +++E E ++ + + E+ ++ + E
Sbjct: 595 EERLEQRLKRE---EVERLEQEERREQRLKREEPEEERRQQLLKSEEQEERRQQQLRREQ 651
Query: 148 EDRKAAKVL----EERIHEEFKRKEEEERKRGEEQIRLQEEQRAKELY------WTLKQA 197
++R+ ++ EER+ + KR+ EEER+ E+++ +E+++A+E W Q
Sbjct: 652 QERREQRLKREEEEERLEQRLKREHEEERR--EQELAEEEQEQARERIKSRIPKW---QW 706
Query: 198 QLHCQASEKEEREW-----EEQLRRSKAADEERSRRAQRA--RDEYRHH 239
QL +A ++ + + +E RR + +E+R RR ++E R H
Sbjct: 707 QLESEADARQSKVYSRPRKQEGQRRRQEQEEKRRRRESELQWQEEERAH 755
Score = 48.5 bits (114), Expect = 9e-06
Identities = 51/228 (22%), Positives = 99/228 (43%), Gaps = 34/228 (14%)
Query: 32 REEQLRRWKERETWEALAQDEGLRPPKTKRAASDKHIQWLLGADGEV--WVWIMGEGPGD 89
RE++L+R +E E E + E + + A ++ Q + W W + E D
Sbjct: 655 REQRLKREEEEERLEQRLKREHEEERREQELAEEEQEQARERIKSRIPKWQWQL-ESEAD 713
Query: 90 --------KPYEEISEELIAERARLQAQREAEELWRQKEAEITKKFRDALANEKARILAE 141
+P ++ + E+ + +RE+E W+++E + R E+ R
Sbjct: 714 ARQSKVYSRPRKQEGQRRRQEQEEKRRRRESELQWQEEE----RAHRQQQEEEQRRDFTW 769
Query: 142 KWKVEMEDRKAAKVLEER--IHEEFKRKEEEERKRGEEQIRLQEEQRAKELYWTLKQAQL 199
+W+ E + + + L R + E+ +R+ E ++ EQ L EE+ ++ ++ Q
Sbjct: 770 QWQAEEKSERGRQRLSARPPLREQRERQLRAEERQQREQRFLPEEEEKEQ-----RRRQR 824
Query: 200 HCQASEKEEREWEEQLRRSKAA------------DEERSRRAQRARDE 235
+ E + E EEQL+R + A D+ER R ++ RD+
Sbjct: 825 REREKELQFLEEEEQLQRRERAQQLQEEEDGLQEDQERRRSQEQRRDQ 872
Score = 48.1 bits (113), Expect = 1e-05
Identities = 58/230 (25%), Positives = 101/230 (43%), Gaps = 57/230 (24%)
Query: 32 REEQLRRWKERETWEALAQDEGLRPPKTKRAASDKHIQWLLGADGEVWVWIMGEGPGDKP 91
R+E+L W++R+ W+ + +R A ++ +Q G + E
Sbjct: 169 RDEEL--WRQRQEWQE----------REERRAEEEQLQSCKGHETE-------------- 202
Query: 92 YEEISEELIAERARLQAQREAEELWRQKEAEITKKFRDALANEKARILAEKWKVEMEDRK 151
E EE + R L+ +R+ E +Q+ E + R+ E+ E E RK
Sbjct: 203 -EFPDEEQLRRRELLELRRKGREEKQQQRRE-----------RQDRVFQEE--EEKEWRK 248
Query: 152 AAKVLEERIHEEFKRKEEEERKR----GEEQIR-------LQEEQRAKELYWTLKQAQLH 200
VL R EE ++EE +R+R EEQ+R +E Q ++ L++ Q
Sbjct: 249 RETVL--RKEEEKLQEEEPQRQRELQEEEEQLRKLERQELRRERQEEEQQQQRLRREQQL 306
Query: 201 CQASEKEEREWEEQLR----RSKAADEERSRRAQRARDEYRHHSLRAIQK 246
+ E+E RE +E+ R R + +E R ++ +R ++E R LR Q+
Sbjct: 307 RRKQEEERREQQEERREQQERREQQEERREQQLRREQEERREQQLRREQE 356
Score = 48.1 bits (113), Expect = 1e-05
Identities = 58/246 (23%), Positives = 103/246 (41%), Gaps = 29/246 (11%)
Query: 97 EELIAERARLQAQREAEELWRQKEAEITKKFRDALANEKARILAEKWKVEMEDRKAAKVL 156
EE ++ Q RE E R++E E + + L E+ ++L E E E R+ +
Sbjct: 1142 EEEEVQQEEEQLLREEPEKRRRQELERQYREEEELQQEEEQLLRE----EQEKRRQERER 1197
Query: 157 EERIHEEFKRKEEEERKRGEEQIRLQEEQRAKELYWTLKQAQLHCQASEKE--------- 207
+ R EE +R++ ++R R E+Q + Q E ++ +++C+ E E
Sbjct: 1198 QYREEEELQRQKRKQRYRDEDQRSDLKWQWEPEKENAVRDNKVYCKGRENEQFRQLEDSQ 1257
Query: 208 --EREWEEQLRRSKAADEERSRRAQRARDEYR------HHSLRAIQKGTVAGLSSMFREL 259
+R+ ++ L+ +ER R +R R + R L ++ +E
Sbjct: 1258 LRDRQSQQDLQHLLGEQQERDREQERRRWQQRDRHFPEEEQLEREEQKEAKRRDRKSQEE 1317
Query: 260 GQ--SHEQEARLYHHLPDPGLPQPLALPVRTWERPLRPVSRDVIVRWFKEEQLPRRAGFE 317
Q E+E + D + L E+PLR RD R F+EE+L + E
Sbjct: 1318 KQLLREEREEKRRRQETDRKFREEEQLLQEREEQPLRRQERD---RKFREEELRHQ---E 1371
Query: 318 RNTKFI 323
+ KF+
Sbjct: 1372 QGRKFL 1377
Score = 48.1 bits (113), Expect = 1e-05
Identities = 87/382 (22%), Positives = 159/382 (41%), Gaps = 50/382 (13%)
Query: 3 QQILHDMYIDPELLAELSDVQKHILFYKMREEQLRRWKERETWEALAQDEGLRPPKTKRA 62
+Q LH D + L E +++ K RE++LR + + L +++ L + +R
Sbjct: 1475 EQQLHRQERDRKFLEEEQQLRRQERDRKFREQELRSQEPERKF--LEEEQQLHRQQRQRK 1532
Query: 63 ASDKHIQWLLGADGEVWVWIMGEGPGDKPYEEISEELIAERARLQAQR-EAEELWRQKEA 121
+ Q G+ D+ + E E+L ER Q R E + +R +E
Sbjct: 1533 FLQEEQQLRRQERGQ-----QRRQDRDRKFRE-EEQLRQEREEQQLSRQERDRKFRLEEQ 1586
Query: 122 EITKKFRDALANEKARILAE-------KWKVEMEDRKAAKVLEERIHEEFKRKE------ 168
++ ++ ++ E + L + + + + R+ ++L+ER ++ R+E
Sbjct: 1587 KVRRQEQERKFMEDEQQLRRQEGQQQLRQERDRKFREDEQLLQEREEQQLHRQERDRKFL 1646
Query: 169 EEE----RKRGEEQIRLQEEQRAKELYWTLKQA---QLHCQASEKEEREWEEQLRRS--- 218
EEE R+ E+Q+R +++ +E L++ QL Q +++ RE E+QLRR
Sbjct: 1647 EEEPQLRRQEREQQLRHDRDRKFREEEQLLQEGEEQQLRRQERDRKFREEEQQLRRQERE 1706
Query: 219 -KAADEERSRRAQRARDEYR-HHSLRAIQKGTVAGLSSMFRELGQSHE-----QEARLYH 271
K EE+ R Q ++R LR + +R++ + + +E +L
Sbjct: 1707 RKFLQEEQQLRRQELERKFREEEQLRQETEQEQLRRQERYRKILEEEQLRPEREEQQLRR 1766
Query: 272 HLPDPGLPQPLALPVRTWERPLRPVSRDVIVRWFKEEQLPRRAGFERNTKFIAPWFHGGN 331
D + L E+ LR D R F+EE+ R+ ER + + P G
Sbjct: 1767 QERDRKFREEEQLRQEREEQQLRSQESD---RKFREEEQLRQ---EREEQQLRPQQRDGK 1820
Query: 332 YHCFRRRVTSGTLRTEGQPTRL 353
Y R L+ E Q RL
Sbjct: 1821 Y-----RWEEEQLQLEEQEQRL 1837
Score = 47.4 bits (111), Expect = 2e-05
Identities = 37/149 (24%), Positives = 72/149 (48%), Gaps = 11/149 (7%)
Query: 92 YEEISEELIAERARLQAQREAEELWRQKEAEITKKFRDALANEKARILAEKWKVEMEDRK 151
++E + + E RL+ Q + ++++ ++ L ++ R E+ + +
Sbjct: 1369 HQEQGRKFLEEEQRLRRQERERKFLKEEQQLRCQEREQQLRQDRDRKFREEEQQLSRQER 1428
Query: 152 AAKVLEERIHEEFKRKEEEERKRGEEQIRLQEEQRAK-----ELYWTLKQAQLHCQASEK 206
K EE E+ R++E ERK EE+ +L++E+ K +L ++ QLH Q ++
Sbjct: 1429 DRKFREE---EQQVRRQERERKFLEEEQQLRQERHRKFREEEQLLQEREEQQLHRQERDR 1485
Query: 207 EEREWEEQLRRSKAADEERSRRAQRARDE 235
+ E E+QLRR + +R R Q R +
Sbjct: 1486 KFLEEEQQLRRQ---ERDRKFREQELRSQ 1511
Score = 47.0 bits (110), Expect = 3e-05
Identities = 38/144 (26%), Positives = 74/144 (51%), Gaps = 16/144 (11%)
Query: 109 QREAEELWRQKEAEITKKFRDALANEKARILAEKWKVEMEDRKAAKVLEERIHEEFKRKE 168
QR + R+KE + ++ E+A+ L E+ ED++ + E+R ++++ +
Sbjct: 819 QRRRQRREREKELQFLEEEEQLQRRERAQQLQEEEDGLQEDQERRRSQEQRRDQKWRWQL 878
Query: 169 EEERKRG----------EEQIRLQEEQRAKELYWTLKQAQLHCQASEKEEREW--EEQLR 216
EEERKR +EQ+R +E+Q +E L++ + + +++ER++ EEQL+
Sbjct: 879 EEERKRRRHTLYAKPALQEQLR-KEQQLLQEEEEELQREEREKRRRQEQERQYREEEQLQ 937
Query: 217 RSK---AADEERSRRAQRARDEYR 237
+ + +E RR Q +YR
Sbjct: 938 QEEEQLLREEREKRRRQERERQYR 961
Score = 46.6 bits (109), Expect = 3e-05
Identities = 45/150 (30%), Positives = 75/150 (50%), Gaps = 16/150 (10%)
Query: 97 EELIAERARLQAQREAEELWRQKEAEITKKFRDALANEKARILAEKWKVEMEDRKAAKVL 156
E L+ +R + + QR E RQ E E ++ R E+ R LAE E + K
Sbjct: 107 ESLLQDRRQEEDQRRFEPRDRQLEEEPGQRRRQK-RQEQERELAEG---EEQSEK----- 157
Query: 157 EERIHEEFKRKEEEERKRGEEQIRLQEEQRAKELYWTLKQAQLHCQASEKEEREWEEQLR 216
+ER+ + +++ +EE R ++ + +EE+RA+E +Q Q C+ E EE EEQLR
Sbjct: 158 QERLEQRDRQRRDEELWRQRQEWQEREERRAEE-----EQLQ-SCKGHETEEFPDEEQLR 211
Query: 217 RSKAADEERSRRAQRARDEYRHHSLRAIQK 246
R + + R R ++ + + R R Q+
Sbjct: 212 RRELLELRRKGREEK-QQQRRERQDRVFQE 240
Score = 44.3 bits (103), Expect = 2e-04
Identities = 52/209 (24%), Positives = 108/209 (51%), Gaps = 27/209 (12%)
Query: 30 KMREEQLRRWKERETWEALAQDEGLRPPKTKRAASDKHIQWLLGADGEVWVWIMGEGPGD 89
K REE+LR ++ + L +++ LR + +R K Q L + E + D
Sbjct: 1361 KFREEELRHQEQGRKF--LEEEQRLRRQERERKFL-KEEQQLRCQEREQQL----RQDRD 1413
Query: 90 KPYEEISEELIAERARLQAQREAEELWRQKEAEITKKFRDALANEKARILAEKWKVEMED 149
+ + E E+ ++ + R + RE E+ R++E E +KF + E+ ++ E+ + +
Sbjct: 1414 RKFRE-EEQQLSRQERDRKFREEEQQVRRQERE--RKFLE----EEQQLRQERHR---KF 1463
Query: 150 RKAAKVLEERIHEEFKRKEEEERKRGEEQIRLQEEQRAKELYWTLKQAQLHCQASEKEER 209
R+ ++L+ER ++ R +E +RK EE+ +L+ ++R ++ ++ +L Q E++
Sbjct: 1464 REEEQLLQEREEQQLHR-QERDRKFLEEEQQLRRQERDRKF----REQELRSQEPERKFL 1518
Query: 210 EWEEQLRRSKAA-----DEERSRRAQRAR 233
E E+QL R + +E++ RR +R +
Sbjct: 1519 EEEQQLHRQQRQRKFLQEEQQLRRQERGQ 1547
Score = 43.5 bits (101), Expect = 3e-04
Identities = 50/210 (23%), Positives = 95/210 (45%), Gaps = 25/210 (11%)
Query: 32 REEQLRRWKERETWEALAQDEGLRPPKTKRAASDKHIQWLLGADGEVWVWIMGEGPGDKP 91
+EE+ RR + W+ ++ R + + D QW E + P P
Sbjct: 735 QEEKRRRRESELQWQE--EERAHRQQQEEEQRRDFTWQWQAEEKSERGRQRLSARP---P 789
Query: 92 YEEISEELIAERARLQAQREAEELWRQKEAEITKKFRDALANEKARILAEKWKVEMEDRK 151
E E + RA + QRE L ++E E ++ R E + E+ +++ R+
Sbjct: 790 LREQRERQL--RAEERQQREQRFLPEEEEKEQRRRQRREREKELQFLEEEE---QLQRRE 844
Query: 152 AAKVLEERIHEEFKRKEEEERKRGEEQIRLQEEQRAKELYWTLKQAQ------LHCQASE 205
A+ L+E EE +E++ER+R QE++R ++ W L++ + L+ + +
Sbjct: 845 RAQQLQE---EEDGLQEDQERRRS------QEQRRDQKWRWQLEEERKRRRHTLYAKPAL 895
Query: 206 KEEREWEEQLRRSKAADEERSRRAQRARDE 235
+E+ E+QL + + + +R R +R R E
Sbjct: 896 QEQLRKEQQLLQEEEEELQREEREKRRRQE 925
Score = 43.1 bits (100), Expect = 4e-04
Identities = 57/250 (22%), Positives = 105/250 (42%), Gaps = 54/250 (21%)
Query: 21 DVQKHILFYKMREEQLRRWKERETWEALAQDEGLRPPKTKRAASDKHIQWLLGADGEVWV 80
D ++ +L + +EE RR++ R+ L ++ G R + KR ++ + A+GE
Sbjct: 104 DGKESLLQDRRQEEDQRRFEPRD--RQLEEEPGQRR-RQKRQEQEREL-----AEGEE-- 153
Query: 81 WIMGEGPGDKPYEEISEELIAERARLQAQREAEELWRQKEAEITKKFRDALANEKARILA 140
+ +E + +R R QR EELWRQ++
Sbjct: 154 ------------QSEKQERLEQRDR---QRRDEELWRQRQ-------------------- 178
Query: 141 EKWKVEMEDRKAAKVLEERIHEEFKRKEEEERKRGEEQIRLQEEQRA-KELYWTLKQAQL 199
+W+ E R + L+ E + +EE+ R E + L+ + R K+ +Q ++
Sbjct: 179 -EWQEREERRAEEEQLQSCKGHETEEFPDEEQLRRRELLELRRKGREEKQQQRRERQDRV 237
Query: 200 HCQASEKEEREWEEQLRRSKAADEERSRRAQRARDEYRHHSLRAIQKGTVAGLSSMFREL 259
+ EKE R+ E LR+ + +E + QR E LR +++ + RE
Sbjct: 238 FQEEEEKEWRKRETVLRKEEEKLQEEEPQRQRELQE-EEEQLRKLER------QELRRER 290
Query: 260 GQSHEQEARL 269
+ +Q+ RL
Sbjct: 291 QEEEQQQQRL 300
Score = 29.6 bits (65), Expect = 4.3
Identities = 21/93 (22%), Positives = 46/93 (49%), Gaps = 2/93 (2%)
Query: 147 MEDRKAAKVLEERIHEEFKRKEEEERKRGEEQIRLQEEQRAKELYWTLKQAQLHCQASEK 206
+++ K A+ + + +R+EE++R+ +L+EE + +Q + + E+
Sbjct: 95 LDEEKRARCDGKESLLQDRRQEEDQRRFEPRDRQLEEEPGQRRRQKRQEQERELAEGEEQ 154
Query: 207 EEREWEEQLRRSKAADEE--RSRRAQRARDEYR 237
E++ + R + DEE R R+ + R+E R
Sbjct: 155 SEKQERLEQRDRQRRDEELWRQRQEWQEREERR 187
>gi|44680105 caldesmon 1 isoform 1 [Homo sapiens]
Length = 793
Score = 69.7 bits (169), Expect = 4e-12
Identities = 58/168 (34%), Positives = 93/168 (55%), Gaps = 21/168 (12%)
Query: 89 DKPYEEISEELIAERARLQAQREAEELWRQKEAEITKKFRDALANEKARILAEKWKVEME 148
+K EE E AERARL EAEE R K AE KK +A+E+ARI E E
Sbjct: 255 EKMEEEDKERAEAERARL----EAEERERIK-AEQDKK----IADERARI-------EAE 298
Query: 149 DRKAAKVLEERIHEEFKRKEEEERKRGEEQIRL-QEEQRAKELYWTLKQAQLHC----QA 203
++ AA+ E R EE +R EEE++ EE+ R+ +EE+RA E +K+ + Q
Sbjct: 299 EKAAAQERERREAEERERMREEEKRAAEERQRIKEEEKRAAEERQRIKEEEKRAAEERQR 358
Query: 204 SEKEEREWEEQLRRSKAADEERSRRAQRARDEYRHHSLRAIQKGTVAG 251
++EE+ E+ +R++A +EE+++ ++ R++ A+Q+ + G
Sbjct: 359 IKEEEKRAAEERQRARAEEEEKAKVEEQKRNKQLEEKKHAMQETKIKG 406
Score = 50.4 bits (119), Expect = 2e-06
Identities = 42/143 (29%), Positives = 80/143 (55%), Gaps = 19/143 (13%)
Query: 94 EISEELIAERARLQAQREAEELWRQK-EAEITKKFRDALANEKARILAEKWKVEMEDRKA 152
E +++ ERAR++A+ +A R++ EAE ++ R+ E+ R E+ +++ E+++A
Sbjct: 283 EQDKKIADERARIEAEEKAAAQERERREAEERERMRE----EEKRAAEERQRIKEEEKRA 338
Query: 153 AKVLEERIHEEFKRKEEEERKRGEEQIRLQEEQRAKELYWTLKQAQLHCQASEKEEREWE 212
A+ +RI EE KR EE R+R +E EE+RA E + +A E+E+ + E
Sbjct: 339 AEE-RQRIKEEEKRAAEE-RQRIKE-----EEKRAAE-------ERQRARAEEEEKAKVE 384
Query: 213 EQLRRSKAADEERSRRAQRARDE 235
EQ R + +++ + + + + E
Sbjct: 385 EQKRNKQLEEKKHAMQETKIKGE 407
Score = 47.8 bits (112), Expect = 2e-05
Identities = 38/171 (22%), Positives = 79/171 (46%), Gaps = 19/171 (11%)
Query: 92 YEEISEELIAERARLQAQREAEELWRQ----KEAEITKKFRDALANEKARILAEKWKVEM 147
YE E + + + R+AEE ++ +E E K R ++ + ++ E+ E
Sbjct: 160 YEIEETETVTKSYQKNDWRDAEENKKEDKEKEEEEEEKPKRGSIGENQVEVMVEEKTTES 219
Query: 148 EDRKAAKVLEERIHEEFKRKEEEERKRGEEQI----RLQEEQRAKELYWTLKQAQLHCQA 203
++ L+ + K+EEER++G ++I +++EE + + ++A+L +
Sbjct: 220 QEETVVMSLKNGQISSEEPKQEEEREQGSDEISHHEKMEEEDKERA---EAERARLEAEE 276
Query: 204 SEKEEREWEEQL--------RRSKAADEERSRRAQRARDEYRHHSLRAIQK 246
E+ + E ++++ KAA +ER RR R+ R RA ++
Sbjct: 277 RERIKAEQDKKIADERARIEAEEKAAAQERERREAEERERMREEEKRAAEE 327
Score = 38.9 bits (89), Expect = 0.007
Identities = 54/259 (20%), Positives = 107/259 (41%), Gaps = 45/259 (17%)
Query: 30 KMREEQLRRWKERETWEALAQDEGLRPPKTKRAASDKHIQWLLGADGEVWVWIMGEGPGD 89
K + E+ +R K+ E + Q+ ++ K ++ K + + ++ ++
Sbjct: 380 KAKVEEQKRNKQLEEKKHAMQETKIKGEKVEQKIEGKWVNEKKAQEDKLQTAVL-----K 434
Query: 90 KPYEEISEELIAERARLQAQREA--------EELWRQKEA-EITKKFRDA------LANE 134
K EE ++ A+R +LQ + E++ + KE E K F D + ++
Sbjct: 435 KQGEEKGTKVQAKREKLQEDKPTFKKEEIKDEKIKKDKEPKEEVKSFMDRKKGFTEVKSQ 494
Query: 135 KARILAEKWK--------------VEMEDRKAAKVLEERIHEEFKRKEEEERKRGE---- 176
+ K K V+ ++ + A +E KR EE R+RGE
Sbjct: 495 NGEFMTHKLKHTENTFSRPGGRASVDTKEAEGAPQVEAG-----KRLEELRRRRGETESE 549
Query: 177 --EQIRLQEEQRAKELYWTLKQAQLHCQASEKEEREWEEQLRRSKAADEERSRRAQRARD 234
E+++ ++++ A EL K+ + + E+EE+ +++ K +EE RR + +
Sbjct: 550 EFEKLKQKQQEAALELEELKKKREERRKVLEEEEQRRKQEEADRKLREEEEKRRLKEEIE 609
Query: 235 EYRHHSLRAIQKGTVAGLS 253
R + QK GLS
Sbjct: 610 RRRAEAAEKRQKMPEDGLS 628
Score = 34.7 bits (78), Expect = 0.13
Identities = 32/136 (23%), Positives = 56/136 (41%), Gaps = 21/136 (15%)
Query: 102 ERARLQAQREAEELWRQKEAE---------ITKKFRDALANEKARILAEKWKVEMEDRKA 152
E AR + +R +E RQK+ E + ++++ +E+A+ +VE +D A
Sbjct: 36 EAARERRRRARQERLRQKQEEESLGQVTDQVEVNAQNSVPDEEAKTTTTNTQVEGDDEAA 95
Query: 153 AKVLEERIHEEFKRKEEEERKRGEEQIRLQEEQRAKELYWTLKQAQLHCQASEKEEREWE 212
E R+EE +KR +E + +R KE T+ A L + + E
Sbjct: 96 -------FLERLARREERRQKRLQEAL-----ERQKEFDPTITDASLSLPSRRMQNDTAE 143
Query: 213 EQLRRSKAADEERSRR 228
+ + E R R
Sbjct: 144 NETTEKEEKSESRQER 159
>gi|239745079 PREDICTED: Putative golgin subfamily A member 6-like
protein 6 [Homo sapiens]
Length = 724
Score = 63.5 bits (153), Expect = 3e-10
Identities = 45/179 (25%), Positives = 98/179 (54%), Gaps = 10/179 (5%)
Query: 93 EEISEELIAERARLQAQREAEELWRQKEAEITKKFRDALANEKARILAEKWKVEMEDRKA 152
E+I E+ R + + R EE+ +KE ++ ++ + + EK + + ++ E +
Sbjct: 382 EKIREQEEKIREQEEKMRRQEEMMWEKEEKMRRQ--EEMMWEKEEKMRRQEEMMWEKEEK 439
Query: 153 AKVLEERIHEEFKRKEEEERKRGEEQIRLQEEQRAKELYWTLKQAQLHCQASEKEEREWE 212
+ LEE++HE+ K +E+EE+++ EE+IR QE+++ +E ++ ++ Q E++ RE E
Sbjct: 440 IRELEEKMHEQEKIREQEEKRQEEEKIREQEKRQEQEAKMWRQEEKIREQ--EEKIREQE 497
Query: 213 EQLRRSKAADEERSRRAQRARDEYRHHSLRAI--QKGTVAGLSSMFRELGQSHEQEARL 269
E++ R EE+ ++ R+E + + Q+ + ++R+ + HEQE ++
Sbjct: 498 EKMWR----QEEKIHEQEKIREEEKRQEQEEMWRQEEKIREQEEIWRQKEKIHEQEEKI 552
Score = 58.5 bits (140), Expect = 9e-09
Identities = 48/187 (25%), Positives = 95/187 (50%), Gaps = 17/187 (9%)
Query: 93 EEISEELIAERARLQAQREAEELWRQKEAEITKKFRDALANEKARILAEKWKVEMEDRKA 152
+ + +EL + A+LQAQ E ELW + + ++ + + ++ +I + K++ ++ K
Sbjct: 329 DHLGKELQSVSAKLQAQVEENELWNR----LNQQQEEKMWRQEEKIQEWEEKIQEQEEKI 384
Query: 153 AKVLEE-RIHEEFKRKEEEERKRGEEQIRLQEE---------QRAKELYWTLKQ--AQLH 200
+ E+ R EE R++EE EE++R QEE +R +E+ W ++ +L
Sbjct: 385 REQEEKIREQEEKMRRQEEMMWEKEEKMRRQEEMMWEKEEKMRRQEEMMWEKEEKIRELE 444
Query: 201 CQASEKEE-REWEEQLRRSKAADEERSRRAQRARDEYRHHSLRAIQKGTVAGLSSMFREL 259
+ E+E+ RE EE+ + + E+ R+ Q A+ + +R ++ M+R+
Sbjct: 445 EKMHEQEKIREQEEKRQEEEKIREQEKRQEQEAKMWRQEEKIREQEEKIREQEEKMWRQE 504
Query: 260 GQSHEQE 266
+ HEQE
Sbjct: 505 EKIHEQE 511
Score = 57.4 bits (137), Expect = 2e-08
Identities = 61/229 (26%), Positives = 116/229 (50%), Gaps = 30/229 (13%)
Query: 30 KMREEQLRRWKERETW---EALAQDEGLRPPKTKRAASDKHIQWLLGADGEVWVWIMGEG 86
K+REE+ +R ++ E W E + + E + K K ++ I+ E +W E
Sbjct: 512 KIREEE-KRQEQEEMWRQEEKIREQEEIWRQKEKIHEQEEKIR-----KQEEKMWRQEEK 565
Query: 87 PGDKPYE--EISEELIAERARLQAQ----REAEELWRQKEAEITKKFRDALANEKARILA 140
D+ + E E++ + +++ Q RE EE R++E E+T++ + + ++ ++
Sbjct: 566 MHDQEEKIREQEEKVWRQEEKIREQEEKIREQEEKIREQE-EMTQEQEEKMGEQEEKMCE 624
Query: 141 EKWKVEMEDRKAAKVLEERIHEEFKRKEEEERKRGEEQIRLQEE--QRAKELYWTLKQAQ 198
++ K++ ++ K + EE+I E+ K+ E+E E+IR QEE Q +E W +Q +
Sbjct: 625 QEEKMQEQEEKMRRQ-EEKIREQEKKIREQE-----EKIREQEEMMQEQEEKMW--EQEE 676
Query: 199 LHCQASEKEEREWEEQLRRSKA---ADEERSRRAQRARDEYRHHSLRAI 244
C+ EK + E EE++RR + E R R+ + E++ H AI
Sbjct: 677 KMCEQEEKMQ-EQEEKMRRQEEKMWEQEVRLRQQEEKMQEHQEHLEAAI 724
Score = 55.8 bits (133), Expect = 6e-08
Identities = 60/260 (23%), Positives = 119/260 (45%), Gaps = 31/260 (11%)
Query: 30 KMREEQLRRWKE----RETWEALAQDEGLRPPKTKRAASDKHIQWLLGADGEVWVWIMGE 85
KMR ++ W++ RE E + + E +R + KR +K + + E +W E
Sbjct: 425 KMRRQEEMMWEKEEKIRELEEKMHEQEKIREQEEKRQEEEKIREQEKRQEQEAKMWRQEE 484
Query: 86 GPGDKPYEEI---------SEELIAERARLQAQ---REAEELWRQKEAEITKKFRDALAN 133
++ E+I EE I E+ +++ + +E EE+WRQ+E K R
Sbjct: 485 KIREQE-EKIREQEEKMWRQEEKIHEQEKIREEEKRQEQEEMWRQEE-----KIR----- 533
Query: 134 EKARILAEKWKVEMEDRKAAKVLEERIHEEFKRKEEEERKRG-EEQIRLQEEQRAKELYW 192
E+ I +K K+ ++ K K E+ +E K ++EE+ R EE++ QEE + +E
Sbjct: 534 EQEEIWRQKEKIHEQEEKIRKQEEKMWRQEEKMHDQEEKIREQEEKVWRQEE-KIREQEE 592
Query: 193 TLKQAQLHCQASEKEEREWEEQL--RRSKAADEERSRRAQRARDEYRHHSLRAIQKGTVA 250
+++ + + E+ +E EE++ + K ++E + Q + + +R +K
Sbjct: 593 KIREQEEKIREQEEMTQEQEEKMGEQEEKMCEQEEKMQEQEEKMRRQEEKIREQEKKIRE 652
Query: 251 GLSSMFRELGQSHEQEARLY 270
+ + EQE +++
Sbjct: 653 QEEKIREQEEMMQEQEEKMW 672
Score = 46.2 bits (108), Expect = 4e-05
Identities = 57/221 (25%), Positives = 106/221 (47%), Gaps = 27/221 (12%)
Query: 32 REEQLRRWKER--ETWEALAQDEGLRPPKTKRAASDKHIQWLLGADGEVWVWIMGEGPGD 89
+EE++RR +E E E + + E + K ++ + + W M E
Sbjct: 394 QEEKMRRQEEMMWEKEEKMRRQEEMMWEKEEKMRRQEEMMWEKEEKIRELEEKMHEQEKI 453
Query: 90 KPYEEISEELIAERARLQAQREAEE--LWRQKEAEITKKFRDALANEKARILAEK-WKVE 146
+ EE +E E+ R Q +R+ +E +WRQ+E K R+ EK R EK W+ E
Sbjct: 454 REQEEKRQE--EEKIREQEKRQEQEAKMWRQEE-----KIREQ--EEKIREQEEKMWRQE 504
Query: 147 MEDRKAAKVLEERIHEEFKR--KEEEERK------RGEEQIRLQEE--QRAKELYWTLKQ 196
+ + K+ EE +E + ++EE+ + R +E+I QEE ++ +E W ++
Sbjct: 505 EKIHEQEKIREEEKRQEQEEMWRQEEKIREQEEIWRQKEKIHEQEEKIRKQEEKMWR-QE 563
Query: 197 AQLHCQASEKEEREWEEQLRRSKAADEERSRRAQRARDEYR 237
++H Q E++ RE EE++ R + E+ + + ++ R
Sbjct: 564 EKMHDQ--EEKIREQEEKVWRQEEKIREQEEKIREQEEKIR 602
Score = 43.1 bits (100), Expect = 4e-04
Identities = 58/250 (23%), Positives = 110/250 (44%), Gaps = 33/250 (13%)
Query: 32 REEQLRRWKERETWEALAQDEGLRPPKTKRAASDKHIQWLLGADGEVWVWIMGEGPGDKP 91
+EE+++ W+E+ Q+E +R + K ++ ++ E +W E +
Sbjct: 366 QEEKIQEWEEK----IQEQEEKIREQEEKIREQEEKMR-----RQEEMMWEKEEKMRRQ- 415
Query: 92 YEEISEELIAERARLQAQREAEELWRQKEAEITKKFRDALANEKARILAEKWKVEMEDRK 151
EE++ E+ + R EE+ +KE +I + EK R EK + E + R+
Sbjct: 416 -----EEMMWEKE--EKMRRQEEMMWEKEEKIRELEEKMHEQEKIREQEEKRQEEEKIRE 468
Query: 152 AAKVLE---------ERIHEEFKRKEEEERK--RGEEQIRLQEEQRAKELYWTLKQAQLH 200
K E E+I E+ ++ E+E K R EE+I QE+ R +E +Q Q
Sbjct: 469 QEKRQEQEAKMWRQEEKIREQEEKIREQEEKMWRQEEKIHEQEKIREEE----KRQEQEE 524
Query: 201 CQASEKEEREWEEQLRRSKAADEERSRRAQRARDEYRHHSLRAIQKGTVAGL-SSMFREL 259
E++ RE EE R+ + E+ + ++ +R Q+ + ++R+
Sbjct: 525 MWRQEEKIREQEEIWRQKEKIHEQEEKIRKQEEKMWRQEEKMHDQEEKIREQEEKVWRQE 584
Query: 260 GQSHEQEARL 269
+ EQE ++
Sbjct: 585 EKIREQEEKI 594
Score = 37.7 bits (86), Expect = 0.016
Identities = 45/186 (24%), Positives = 85/186 (45%), Gaps = 28/186 (15%)
Query: 97 EELIAERARLQAQREAEELWRQKEAEITKKFRDALANEKARILAEKWKVEMED------- 149
EEL + A+LQ + + E + + K+ + L E+A++L + +++ E
Sbjct: 278 EELKEKNAKLQEKLQLVESEKSEIQLNVKELKRKL--ERAKLLLPQQQLQAEADHLGKEL 335
Query: 150 -----RKAAKVLEERIHEEFKRKEEEERKRGEEQIRLQEEQRAKELYWTLKQAQLHCQAS 204
+ A+V E + +++EE+ R EE+I+ EE+ +++ + +
Sbjct: 336 QSVSAKLQAQVEENELWNRLNQQQEEKMWRQEEKIQEWEEK--------IQEQEEKIREQ 387
Query: 205 EKEEREWEEQLRRSKA---ADEERSRRAQRARDEYRHHSLRAIQKGTVAGLSSMFRELGQ 261
E++ RE EE++RR + EE+ RR + E R Q+ + REL +
Sbjct: 388 EEKIREQEEKMRRQEEMMWEKEEKMRRQEEMMWEKEEKMRR--QEEMMWEKEEKIRELEE 445
Query: 262 S-HEQE 266
HEQE
Sbjct: 446 KMHEQE 451
>gi|239745153 PREDICTED: similar to Putative golgin subfamily A
member 6-like protein 6 [Homo sapiens]
Length = 655
Score = 62.4 bits (150), Expect = 6e-10
Identities = 64/235 (27%), Positives = 119/235 (50%), Gaps = 28/235 (11%)
Query: 30 KMREEQLRRWKERETWEALAQDEGLRPPKTKRAASDKHI----QWLLGADGEVWVWIMGE 85
K+RE++ + W++ E Q+E +R + K ++ I + + + ++W
Sbjct: 319 KIREQEEKMWRQEEKMHE--QEEKIREQEDKMWRQEEKIREQEEKIREQEEKMWRQEEKI 376
Query: 86 GPGDKPYEEISEELIA--ERARLQAQREAEELWRQ--KEAEITKKFRDA-----LANEKA 136
D+ +E EE+ E+ R Q ++ E++WRQ K E +K R+ EK
Sbjct: 377 REQDEKIQEQEEEMWRQEEKIREQEEKRQEKMWRQEKKMREQDEKIREQEEEMWRQEEKI 436
Query: 137 RILAEKWKVEMEDRKAAKVLEERIHEEFKRKEEEER-KRGEEQIRLQEEQ--RAKELYWT 193
R L E ++ ++ K +V E+ EE K +E+EE+ +R EE+I+ QEE+ R ++L
Sbjct: 437 RELEEM--MQDQEEKLREVEEKMQEEEEKMQEQEEKIQRQEEKIQEQEEKTWRQEKL--- 491
Query: 194 LKQAQLHCQASEKEEREW--EEQLRRSKAADEERSRRAQRARDEYRHHSLRAIQK 246
LKQ + + E+EE+ W EE++ + +E+ + QR ++ R +R Q+
Sbjct: 492 LKQEE---KIWEQEEKMWRQEEKMWEQEEKMQEQEEKMQRQEEKMREQEVRLWQQ 543
Score = 52.0 bits (123), Expect = 8e-07
Identities = 41/201 (20%), Positives = 95/201 (47%), Gaps = 30/201 (14%)
Query: 93 EEISEELIAERARLQAQREAEELWR---QKEAEITKKFRDALANEKARILAEKWKVEMED 149
+ + +EL + A+LQAQ E ELW Q++ E + + + ++ ++ ++ K+ ++
Sbjct: 265 DRLGKELQSVSAKLQAQVEENELWNLLNQQQEEKMWRQEEKIQEQEEKMCEQELKIREQE 324
Query: 150 RKAAKVLEERIHEEFK-----------------------RKEEEERKRGEEQIRLQEE-- 184
K + EE++HE+ + R++EE+ R EE+IR Q+E
Sbjct: 325 EKMWRQ-EEKMHEQEEKIREQEDKMWRQEEKIREQEEKIREQEEKMWRQEEKIREQDEKI 383
Query: 185 QRAKELYWTLKQAQLHCQASEKEEREWEEQLRRSKAADEERSRRAQRARDEYRHHSLRAI 244
Q +E W ++ ++ Q +++E+ W ++ + + ++ R + + R E + L +
Sbjct: 384 QEQEEEMWR-QEEKIREQEEKRQEKMWRQEKKMREQDEKIREQEEEMWRQEEKIRELEEM 442
Query: 245 QKGTVAGLSSMFRELGQSHEQ 265
+ L + ++ + E+
Sbjct: 443 MQDQEEKLREVEEKMQEEEEK 463
Score = 36.6 bits (83), Expect = 0.035
Identities = 37/187 (19%), Positives = 88/187 (47%), Gaps = 17/187 (9%)
Query: 94 EISEEL-IAERARLQAQREAEELWRQKEAEITKKFRDALANEKARI------LAEKWKVE 146
E+ E+L + E + + Q ++L R+ E + L E R+ ++ K + +
Sbjct: 222 ELQEKLRLVESEKSEIQLNVKDLKRKLERAQLLLPQQQLQVEADRLGKELQSVSAKLQAQ 281
Query: 147 MEDRKAAKVLEERIHEEFKRKEEEERKRGEEQIRLQEEQRAKELYWTLKQAQLHCQAS-- 204
+E+ + +L ++ E+ R+EE+ +++ E+ + + R +E ++ ++H Q
Sbjct: 282 VEENELWNLLNQQQEEKMWRQEEKIQEQEEKMCEQELKIREQEEKMWRQEEKMHEQEEKI 341
Query: 205 -EKEEREW--EEQLRRSKAADEERSRRAQRARDEYRHHSLRAIQKGTVAGLSSMFRELGQ 261
E+E++ W EE++R + E+ + R ++ R + ++ M+R+ +
Sbjct: 342 REQEDKMWRQEEKIREQEEKIREQEEKMWRQEEKIREQDEKIQEQE-----EEMWRQEEK 396
Query: 262 SHEQEAR 268
EQE +
Sbjct: 397 IREQEEK 403
>gi|239745127 PREDICTED: similar to Putative golgin subfamily A
member 6-like protein 6 [Homo sapiens]
Length = 655
Score = 62.4 bits (150), Expect = 6e-10
Identities = 64/235 (27%), Positives = 119/235 (50%), Gaps = 28/235 (11%)
Query: 30 KMREEQLRRWKERETWEALAQDEGLRPPKTKRAASDKHI----QWLLGADGEVWVWIMGE 85
K+RE++ + W++ E Q+E +R + K ++ I + + + ++W
Sbjct: 319 KIREQEEKMWRQEEKMHE--QEEKIREQEDKMWRQEEKIREQEEKIREQEEKMWRQEEKI 376
Query: 86 GPGDKPYEEISEELIA--ERARLQAQREAEELWRQ--KEAEITKKFRDA-----LANEKA 136
D+ +E EE+ E+ R Q ++ E++WRQ K E +K R+ EK
Sbjct: 377 REQDEKIQEQEEEMWRQEEKIREQEEKRQEKMWRQEKKMREQDEKIREQEEEMWRQEEKI 436
Query: 137 RILAEKWKVEMEDRKAAKVLEERIHEEFKRKEEEER-KRGEEQIRLQEEQ--RAKELYWT 193
R L E ++ ++ K +V E+ EE K +E+EE+ +R EE+I+ QEE+ R ++L
Sbjct: 437 RELEEM--MQDQEEKLREVEEKMQEEEEKMQEQEEKIQRQEEKIQEQEEKTWRQEKL--- 491
Query: 194 LKQAQLHCQASEKEEREW--EEQLRRSKAADEERSRRAQRARDEYRHHSLRAIQK 246
LKQ + + E+EE+ W EE++ + +E+ + QR ++ R +R Q+
Sbjct: 492 LKQEE---KIWEQEEKMWRQEEKMWEQEEKMQEQEEKMQRQEEKMREQEVRLWQQ 543
Score = 52.0 bits (123), Expect = 8e-07
Identities = 41/201 (20%), Positives = 95/201 (47%), Gaps = 30/201 (14%)
Query: 93 EEISEELIAERARLQAQREAEELWR---QKEAEITKKFRDALANEKARILAEKWKVEMED 149
+ + +EL + A+LQAQ E ELW Q++ E + + + ++ ++ ++ K+ ++
Sbjct: 265 DRLGKELQSVSAKLQAQVEENELWNLLNQQQEEKMWRQEEKIQEQEEKMCEQELKIREQE 324
Query: 150 RKAAKVLEERIHEEFK-----------------------RKEEEERKRGEEQIRLQEE-- 184
K + EE++HE+ + R++EE+ R EE+IR Q+E
Sbjct: 325 EKMWRQ-EEKMHEQEEKIREQEDKMWRQEEKIREQEEKIREQEEKMWRQEEKIREQDEKI 383
Query: 185 QRAKELYWTLKQAQLHCQASEKEEREWEEQLRRSKAADEERSRRAQRARDEYRHHSLRAI 244
Q +E W ++ ++ Q +++E+ W ++ + + ++ R + + R E + L +
Sbjct: 384 QEQEEEMWR-QEEKIREQEEKRQEKMWRQEKKMREQDEKIREQEEEMWRQEEKIRELEEM 442
Query: 245 QKGTVAGLSSMFRELGQSHEQ 265
+ L + ++ + E+
Sbjct: 443 MQDQEEKLREVEEKMQEEEEK 463
Score = 36.6 bits (83), Expect = 0.035
Identities = 37/187 (19%), Positives = 88/187 (47%), Gaps = 17/187 (9%)
Query: 94 EISEEL-IAERARLQAQREAEELWRQKEAEITKKFRDALANEKARI------LAEKWKVE 146
E+ E+L + E + + Q ++L R+ E + L E R+ ++ K + +
Sbjct: 222 ELQEKLRLVESEKSEIQLNVKDLKRKLERAQLLLPQQQLQVEADRLGKELQSVSAKLQAQ 281
Query: 147 MEDRKAAKVLEERIHEEFKRKEEEERKRGEEQIRLQEEQRAKELYWTLKQAQLHCQAS-- 204
+E+ + +L ++ E+ R+EE+ +++ E+ + + R +E ++ ++H Q
Sbjct: 282 VEENELWNLLNQQQEEKMWRQEEKIQEQEEKMCEQELKIREQEEKMWRQEEKMHEQEEKI 341
Query: 205 -EKEEREW--EEQLRRSKAADEERSRRAQRARDEYRHHSLRAIQKGTVAGLSSMFRELGQ 261
E+E++ W EE++R + E+ + R ++ R + ++ M+R+ +
Sbjct: 342 REQEDKMWRQEEKIREQEEKIREQEEKMWRQEEKIREQDEKIQEQE-----EEMWRQEEK 396
Query: 262 SHEQEAR 268
EQE +
Sbjct: 397 IREQEEK 403
>gi|102467235 inner centromere protein antigens 135/155kDa isoform 1
[Homo sapiens]
Length = 918
Score = 62.4 bits (150), Expect = 6e-10
Identities = 48/184 (26%), Positives = 89/184 (48%), Gaps = 14/184 (7%)
Query: 93 EEISEELIAERARLQAQREAEELWRQKEAEITKKFRDALANEKARILAEKWKVEME---- 148
+E +E+L ++ +R EE+ ++E + K + A E+ + E+ K ++E
Sbjct: 548 KEEAEQLRRQKVEEDKRRRLEEVKLKREERLRKVLQ---ARERVEQMKEEKKKQIEQKFA 604
Query: 149 --DRKAAKVLEERIHEEFKRKEEEERKRGEEQIRLQEEQRAKELYWTLKQAQ--LHCQAS 204
D K K EER+ EE +K+ +K E + R ++E+ A+ L W ++ + H +
Sbjct: 605 QIDEKTEKAKEERLAEEKAKKKAAAKKMEEVEARRKQEEEARRLRWLQQEEEERRHQELL 664
Query: 205 EKEEREWEEQLRRSKAADEERSRRAQRARDEYRHHSLRAIQKGTVAGLSSMFRELGQSHE 264
+K++ E +E+LR++ A +R Q R++ R R Q+ R+L E
Sbjct: 665 QKKKEEEQERLRKAAEAKRLAEQREQERREQERREQERREQERREQERREQERQLA---E 721
Query: 265 QEAR 268
QE R
Sbjct: 722 QERR 725
Score = 59.7 bits (143), Expect = 4e-09
Identities = 54/214 (25%), Positives = 106/214 (49%), Gaps = 14/214 (6%)
Query: 24 KHILFYKMREEQLRRWKERETWEALAQ-DEGLRPPKTKRAASDKHIQWLLGADGEVWVWI 82
+ +L + R EQ++ K+++ + AQ DE K +R A +K A +
Sbjct: 579 RKVLQARERVEQMKEEKKKQIEQKFAQIDEKTEKAKEERLAEEK-------AKKKAAAKK 631
Query: 83 MGEGPGDKPYEEISEELIAERARLQAQREAEELWRQKEAEITKKFRDALANEKARILAEK 142
M E + EE + L + + +R E L ++KE E ++ R A ++ E+
Sbjct: 632 MEEVEARRKQEEEARRLRWLQQEEEERRHQELLQKKKEEE-QERLRKAAEAKRLAEQREQ 690
Query: 143 WKVEMEDRKAAKVLEERIHEEFKRKE----EEERKRGEEQIRLQEEQRAKELYWTLKQAQ 198
+ E E R+ + +ER +E + +E E+ER+R +E+++ + E + +E L++ Q
Sbjct: 691 ERREQERREQERREQERREQERREQERQLAEQERRREQERLQAERELQEREKALRLQKEQ 750
Query: 199 LHCQASEKEEREWEEQLRRSKAADEERSRRAQRA 232
L + EK+++E E+Q + EE+ ++A+ A
Sbjct: 751 LQRELEEKKKKE-EQQRLAERQLQEEQEKKAKEA 783
Score = 55.5 bits (132), Expect = 7e-08
Identities = 54/187 (28%), Positives = 88/187 (47%), Gaps = 26/187 (13%)
Query: 103 RARLQAQREAEELWRQKEAEITKKF-----------RDALANEKARILAEKWKVEMEDRK 151
R LQA+ E++ +K+ +I +KF + LA EKA+ A K+E + +
Sbjct: 579 RKVLQARERVEQMKEEKKKQIEQKFAQIDEKTEKAKEERLAEEKAKKKAAAKKMEEVEAR 638
Query: 152 AAKVLEERIHEEFKRKEEEER-------KRGEEQIRLQEEQRAKELYWTLKQAQLHCQAS 204
+ E R +++EEE R K+ EEQ RL++ AK L +Q + +
Sbjct: 639 RKQEEEARRLRWLQQEEEERRHQELLQKKKEEEQERLRKAAEAKRLAEQREQERREQERR 698
Query: 205 EKEEREWE--EQLRRS---KAADEERSRRAQRARDEYRHHSLRAIQKGTVAGLSSMFREL 259
E+E RE E EQ RR + A++ER R +R + E L+ +K + REL
Sbjct: 699 EQERREQERREQERREQERQLAEQERRREQERLQAE---RELQEREKALRLQKEQLQREL 755
Query: 260 GQSHEQE 266
+ ++E
Sbjct: 756 EEKKKKE 762
Score = 47.4 bits (111), Expect = 2e-05
Identities = 50/170 (29%), Positives = 82/170 (48%), Gaps = 25/170 (14%)
Query: 89 DKPYEEISEELIAE---RARLQAQREAEELWRQKEAEITKKFRDALANEKAR----ILAE 141
D+ E+ EE +AE + + A++ E R+K+ E ++ R E+ R +L +
Sbjct: 607 DEKTEKAKEERLAEEKAKKKAAAKKMEEVEARRKQEEEARRLRWLQQEEEERRHQELLQK 666
Query: 142 KWKVEMED-RKAAKVLEERIHEEFKRKEEE------------ERKRGEEQIRLQEEQRAK 188
K + E E RKAA+ E +R+E+E E++R E++ +L E++R +
Sbjct: 667 KKEEEQERLRKAAEAKRLAEQREQERREQERREQERREQERREQERREQERQLAEQERRR 726
Query: 189 ELYWTLKQAQLHCQASEKEEREWEEQLRR---SKAADEERSRRAQRARDE 235
E QA+ Q EK R +EQL+R K EE+ R A+R E
Sbjct: 727 E--QERLQAERELQEREKALRLQKEQLQRELEEKKKKEEQQRLAERQLQE 774
Score = 34.3 bits (77), Expect = 0.18
Identities = 34/125 (27%), Positives = 58/125 (46%), Gaps = 27/125 (21%)
Query: 149 DRKAAKVLEERIH-EEFKRKE----------EEERKRGEEQIRLQEEQR------AKELY 191
D K + V +ER E +RKE EE+++R E+++L+ E+R A+E
Sbjct: 529 DPKCSFVEKERQRLENLRRKEEAEQLRRQKVEEDKRRRLEEVKLKREERLRKVLQARERV 588
Query: 192 WTLKQ------AQLHCQASEKEEREWEEQLRRSKAADEERSRRAQ----RARDEYRHHSL 241
+K+ Q Q EK E+ EE+L KA + +++ + R + E L
Sbjct: 589 EQMKEEKKKQIEQKFAQIDEKTEKAKEERLAEEKAKKKAAAKKMEEVEARRKQEEEARRL 648
Query: 242 RAIQK 246
R +Q+
Sbjct: 649 RWLQQ 653
>gi|102467242 inner centromere protein antigens 135/155kDa isoform 2
[Homo sapiens]
Length = 914
Score = 62.4 bits (150), Expect = 6e-10
Identities = 48/184 (26%), Positives = 89/184 (48%), Gaps = 14/184 (7%)
Query: 93 EEISEELIAERARLQAQREAEELWRQKEAEITKKFRDALANEKARILAEKWKVEME---- 148
+E +E+L ++ +R EE+ ++E + K + A E+ + E+ K ++E
Sbjct: 544 KEEAEQLRRQKVEEDKRRRLEEVKLKREERLRKVLQ---ARERVEQMKEEKKKQIEQKFA 600
Query: 149 --DRKAAKVLEERIHEEFKRKEEEERKRGEEQIRLQEEQRAKELYWTLKQAQ--LHCQAS 204
D K K EER+ EE +K+ +K E + R ++E+ A+ L W ++ + H +
Sbjct: 601 QIDEKTEKAKEERLAEEKAKKKAAAKKMEEVEARRKQEEEARRLRWLQQEEEERRHQELL 660
Query: 205 EKEEREWEEQLRRSKAADEERSRRAQRARDEYRHHSLRAIQKGTVAGLSSMFRELGQSHE 264
+K++ E +E+LR++ A +R Q R++ R R Q+ R+L E
Sbjct: 661 QKKKEEEQERLRKAAEAKRLAEQREQERREQERREQERREQERREQERREQERQLA---E 717
Query: 265 QEAR 268
QE R
Sbjct: 718 QERR 721
Score = 59.7 bits (143), Expect = 4e-09
Identities = 54/214 (25%), Positives = 106/214 (49%), Gaps = 14/214 (6%)
Query: 24 KHILFYKMREEQLRRWKERETWEALAQ-DEGLRPPKTKRAASDKHIQWLLGADGEVWVWI 82
+ +L + R EQ++ K+++ + AQ DE K +R A +K A +
Sbjct: 575 RKVLQARERVEQMKEEKKKQIEQKFAQIDEKTEKAKEERLAEEK-------AKKKAAAKK 627
Query: 83 MGEGPGDKPYEEISEELIAERARLQAQREAEELWRQKEAEITKKFRDALANEKARILAEK 142
M E + EE + L + + +R E L ++KE E ++ R A ++ E+
Sbjct: 628 MEEVEARRKQEEEARRLRWLQQEEEERRHQELLQKKKEEE-QERLRKAAEAKRLAEQREQ 686
Query: 143 WKVEMEDRKAAKVLEERIHEEFKRKE----EEERKRGEEQIRLQEEQRAKELYWTLKQAQ 198
+ E E R+ + +ER +E + +E E+ER+R +E+++ + E + +E L++ Q
Sbjct: 687 ERREQERREQERREQERREQERREQERQLAEQERRREQERLQAERELQEREKALRLQKEQ 746
Query: 199 LHCQASEKEEREWEEQLRRSKAADEERSRRAQRA 232
L + EK+++E E+Q + EE+ ++A+ A
Sbjct: 747 LQRELEEKKKKE-EQQRLAERQLQEEQEKKAKEA 779
Score = 55.5 bits (132), Expect = 7e-08
Identities = 54/187 (28%), Positives = 88/187 (47%), Gaps = 26/187 (13%)
Query: 103 RARLQAQREAEELWRQKEAEITKKF-----------RDALANEKARILAEKWKVEMEDRK 151
R LQA+ E++ +K+ +I +KF + LA EKA+ A K+E + +
Sbjct: 575 RKVLQARERVEQMKEEKKKQIEQKFAQIDEKTEKAKEERLAEEKAKKKAAAKKMEEVEAR 634
Query: 152 AAKVLEERIHEEFKRKEEEER-------KRGEEQIRLQEEQRAKELYWTLKQAQLHCQAS 204
+ E R +++EEE R K+ EEQ RL++ AK L +Q + +
Sbjct: 635 RKQEEEARRLRWLQQEEEERRHQELLQKKKEEEQERLRKAAEAKRLAEQREQERREQERR 694
Query: 205 EKEEREWE--EQLRRS---KAADEERSRRAQRARDEYRHHSLRAIQKGTVAGLSSMFREL 259
E+E RE E EQ RR + A++ER R +R + E L+ +K + REL
Sbjct: 695 EQERREQERREQERREQERQLAEQERRREQERLQAE---RELQEREKALRLQKEQLQREL 751
Query: 260 GQSHEQE 266
+ ++E
Sbjct: 752 EEKKKKE 758
Score = 47.4 bits (111), Expect = 2e-05
Identities = 50/170 (29%), Positives = 82/170 (48%), Gaps = 25/170 (14%)
Query: 89 DKPYEEISEELIAE---RARLQAQREAEELWRQKEAEITKKFRDALANEKAR----ILAE 141
D+ E+ EE +AE + + A++ E R+K+ E ++ R E+ R +L +
Sbjct: 603 DEKTEKAKEERLAEEKAKKKAAAKKMEEVEARRKQEEEARRLRWLQQEEEERRHQELLQK 662
Query: 142 KWKVEMED-RKAAKVLEERIHEEFKRKEEE------------ERKRGEEQIRLQEEQRAK 188
K + E E RKAA+ E +R+E+E E++R E++ +L E++R +
Sbjct: 663 KKEEEQERLRKAAEAKRLAEQREQERREQERREQERREQERREQERREQERQLAEQERRR 722
Query: 189 ELYWTLKQAQLHCQASEKEEREWEEQLRR---SKAADEERSRRAQRARDE 235
E QA+ Q EK R +EQL+R K EE+ R A+R E
Sbjct: 723 E--QERLQAERELQEREKALRLQKEQLQRELEEKKKKEEQQRLAERQLQE 770
>gi|222418637 golgi autoantigen, golgin subfamily a-like [Homo
sapiens]
Length = 750
Score = 62.0 bits (149), Expect = 8e-10
Identities = 62/244 (25%), Positives = 112/244 (45%), Gaps = 42/244 (17%)
Query: 32 REEQLRRWKER--ETWEALAQDEGLRPPKTKRAASDKHIQWLLGADGEVWVWIMGEGPGD 89
+EE++RR +E E E + + E + K ++ + + W M E
Sbjct: 347 KEEKMRRQEEMMWEKEEKMRRQEEMMWEKEEKMRRQEEMMWEKEEKIRELEEKMHEQEKI 406
Query: 90 KPYEEISEELIAERARLQAQREAEE--LWRQKEAEITKKFRDALANEKARILAEKWKVEM 147
+ EE +E E+ R Q +R+ +E +WRQ+E +I ++ K+
Sbjct: 407 REQEEKRQE--EEKIREQEKRQEQEAKMWRQEE----------------KIREQEEKIRE 448
Query: 148 EDRKAAKVLEERIHEEFKRKEEEERKRGEEQIRLQEEQRAKELYWTLKQAQLHCQAS--- 204
+++K + EE+IHE+ K +EEE+R+ EE R +E+ +E W K+ ++H Q
Sbjct: 449 QEKKMWRQ-EEKIHEQEKIREEEKRQEQEEMWRQEEKIHEQEEIWRQKE-KMHEQEEKIR 506
Query: 205 EKEEREW--EEQLRRSKAADEERSRRAQRARDEYRHHSLRAIQKGTVAGLSSMFRELGQS 262
++EE+ W EE++R + E+ + R ++ R M+RE +
Sbjct: 507 KQEEKVWRQEEKIREQEEKIREQEEKMWRQEEKIREQ-------------EEMWREEEKM 553
Query: 263 HEQE 266
HEQE
Sbjct: 554 HEQE 557
Score = 60.1 bits (144), Expect = 3e-09
Identities = 42/175 (24%), Positives = 97/175 (55%), Gaps = 12/175 (6%)
Query: 97 EELIAERARLQAQREAEELWRQKEAEITKKFRDALANEKARILAEKWKVEMEDRKAAKVL 156
EE++ E+ + +R+ E +W ++E + ++ + EK + + ++ E + + L
Sbjct: 341 EEMMWEKEE-KMRRQEEMMWEKEEK---MRRQEEMMWEKEEKMRRQEEMMWEKEEKIREL 396
Query: 157 EERIHEEFKRKEEEERKRGEEQIRLQEEQRAKELYWTLKQAQLHCQASEKEEREWEEQLR 216
EE++HE+ K +E+EE+++ EE+IR QE+++ +E ++ ++ Q E++ RE E+++
Sbjct: 397 EEKMHEQEKIREQEEKRQEEEKIREQEKRQEQEAKMWRQEEKIREQ--EEKIREQEKKMW 454
Query: 217 RSKAADEERSRRAQRARDEYRHHSLRAI--QKGTVAGLSSMFRELGQSHEQEARL 269
R EE+ ++ R+E + + Q+ + ++R+ + HEQE ++
Sbjct: 455 R----QEEKIHEQEKIREEEKRQEQEEMWRQEEKIHEQEEIWRQKEKMHEQEEKI 505
Score = 57.0 bits (136), Expect = 3e-08
Identities = 51/249 (20%), Positives = 123/249 (49%), Gaps = 21/249 (8%)
Query: 30 KMREEQLRRWKERETWEALAQDEGLRPPKTKRAASDKHIQWLLGADGEVWVWIMGEGPGD 89
K+R+++ + W++ E + Q+E +R + K ++ I+ E+W +
Sbjct: 504 KIRKQEEKVWRQEE--KIREQEEKIREQEEKMWRQEEKIR----EQEEMWREEEKMHEQE 557
Query: 90 KPYEEISEELIAERARLQAQR---EAEELWRQKEA-----EITKKFRDALANEKARILAE 141
K +EE + ++ Q ++ + E++WRQ+E E ++ + + ++ +I +
Sbjct: 558 KIWEEEKRQEQEDKMWRQEEKIREQEEKVWRQEEKIREQEEKRQEQEEKMWKQEEKIREQ 617
Query: 142 KWKVEMEDRKAAKVLEERIHEEFKRKEEEERKRGEEQIRL-QEEQRAKELYWTLKQAQLH 200
+ K++ ++ K + EE+I E+ + +E+E K GE++ ++ ++E++ +E T+ + +
Sbjct: 618 EEKIQEQEEKIREQ-EEKIREQEEMTQEQEEKMGEQEEKMCEQEEKMQEQEETMWRQEEK 676
Query: 201 CQASEKEEREWEEQLRRSKAADEERSRRAQRARDEYRHHSLRAIQKGTVAGLSSMFRELG 260
+ EK+ RE EE++R + +E+ + ++ + ++ M R+
Sbjct: 677 IREQEKKIREQEEKIREQEEMMQEQEEKMWEQEEKMCEQEEKMQEQE-----EKMRRQEE 731
Query: 261 QSHEQEARL 269
+ EQE RL
Sbjct: 732 KMWEQEVRL 740
Score = 55.5 bits (132), Expect = 7e-08
Identities = 45/184 (24%), Positives = 96/184 (52%), Gaps = 24/184 (13%)
Query: 93 EEISEELIAERARLQAQREAEELWRQKEAEITKKFRDALANEKARILAEKWKVEMEDRKA 152
+ + +EL + A+LQAQ E ELW + + ++ + + ++ +I ++W+ +++++
Sbjct: 268 DHLGKELQSVSAKLQAQVEENELWNR----LNQQQEEKMWRQEEKI--QEWEEKIQEQ-- 319
Query: 153 AKVLEERIHE-EFKRKEEEERKRGEEQIRLQEEQ---RAKELYWTLKQAQLHCQASEKEE 208
EE+I E E K +E+EE+ R +E++ ++E+ R +E+ W ++ + +EE
Sbjct: 320 ----EEKIREQEEKIREQEEKMRRQEEMMWEKEEKMRRQEEMMWEKEE-----KMRRQEE 370
Query: 209 REW--EEQLRRSKAADEERSRRAQRARDEYRHHSLRAIQKGTVAGLSSMFRELGQSHEQE 266
W EE++RR + E+ + R +E H + ++ RE + EQE
Sbjct: 371 MMWEKEEKMRRQEEMMWEKEEKI-RELEEKMHEQEKIREQEEKRQEEEKIREQEKRQEQE 429
Query: 267 ARLY 270
A+++
Sbjct: 430 AKMW 433
Score = 55.1 bits (131), Expect = 1e-07
Identities = 55/252 (21%), Positives = 120/252 (47%), Gaps = 20/252 (7%)
Query: 30 KMREEQLRRWKE----RETWEALAQDEGLRPPKTKRAASDKHIQWLLGADGEVWVWIMGE 85
KMR ++ W++ RE E + + E +R + KR +K + + E +W E
Sbjct: 378 KMRRQEEMMWEKEEKIRELEEKMHEQEKIREQEEKRQEEEKIREQEKRQEQEAKMWRQEE 437
Query: 86 G--PGDKPYEEISEELIAERARLQAQREA-EELWRQKEAEITKKFRDALANEKARILAEK 142
++ E +++ + ++ Q + EE RQ++ E+ + ++ +E+ I +K
Sbjct: 438 KIREQEEKIREQEKKMWRQEEKIHEQEKIREEEKRQEQEEMWR--QEEKIHEQEEIWRQK 495
Query: 143 WKVEMEDRKAAKVLEE--RIHEEFKRKEEEERKRGEEQIRLQEEQRAKELYWTLKQAQLH 200
K+ ++ K K E+ R E+ + +EE+ R++ E+ R +E+ R +E W ++ ++H
Sbjct: 496 EKMHEQEEKIRKQEEKVWRQEEKIREQEEKIREQEEKMWRQEEKIREQEEMWR-EEEKMH 554
Query: 201 CQASEKEEREWEEQLRR---SKAADEERSRRAQRARDEYRHHSLRAIQKGTVAGLSSMFR 257
++E+ WEE+ R+ K +E R Q + + +R ++ M++
Sbjct: 555 -----EQEKIWEEEKRQEQEDKMWRQEEKIREQEEKVWRQEEKIREQEEKRQEQEEKMWK 609
Query: 258 ELGQSHEQEARL 269
+ + EQE ++
Sbjct: 610 QEEKIREQEEKI 621
Score = 53.9 bits (128), Expect = 2e-07
Identities = 52/210 (24%), Positives = 105/210 (50%), Gaps = 35/210 (16%)
Query: 32 REEQLRRWKERETWEALAQDEGLRPPKTKRAASDKHIQWLLGADGEVWVWIMGEGPGDKP 91
R+E+ R +E + W Q+E +R + KR ++ ++W K
Sbjct: 574 RQEEKIREQEEKVWR---QEEKIREQEEKRQEQEE----------KMW----------KQ 610
Query: 92 YEEISEELIAERARLQAQREAEELWRQKEAEITKKFRDALANEKARILAEKWKVEMEDRK 151
E+I E+ + + + RE EE R++E E+T++ + + ++ ++ ++ K++ ++
Sbjct: 611 EEKIREQEEKIQEQEEKIREQEEKIREQE-EMTQEQEEKMGEQEEKMCEQEEKMQEQEET 669
Query: 152 AAKVLEERIHEEFKRKEEEERKRGEEQIRLQEE--QRAKELYWTLKQAQLHCQASEKEER 209
+ EE+I E+ K+ E+E E+IR QEE Q +E W +Q + C+ EK +
Sbjct: 670 MWRQ-EEKIREQEKKIREQE-----EKIREQEEMMQEQEEKMW--EQEEKMCEQEEKMQ- 720
Query: 210 EWEEQLRRSKAADEERSRRAQRARDEYRHH 239
E EE++RR + E+ R ++ ++ + H
Sbjct: 721 EQEEKMRRQEEKMWEQEVRLRQQEEKMQEH 750
Score = 53.5 bits (127), Expect = 3e-07
Identities = 50/221 (22%), Positives = 106/221 (47%), Gaps = 20/221 (9%)
Query: 30 KMREEQLRRWKERETW---EALAQDEGLRPPKTKRAASDKHIQWLLGADGEVWVWIMGEG 86
K+REE+ +R ++ E W E + + E + K K ++ I+ E VW E
Sbjct: 465 KIREEE-KRQEQEEMWRQEEKIHEQEEIWRQKEKMHEQEEKIR-----KQEEKVWRQEEK 518
Query: 87 PGDKPYEEISEELIAERARLQAQREAEELWRQKEA----------EITKKFRDALANEKA 136
++ E+I E+ + + RE EE+WR++E E ++ D + ++
Sbjct: 519 IREQE-EKIREQEEKMWRQEEKIREQEEMWREEEKMHEQEKIWEEEKRQEQEDKMWRQEE 577
Query: 137 RILAEKWKVEMEDRKAAKVLEERIHEEFKRKEEEERKRGEEQIRLQEEQRAKELYWTLKQ 196
+I ++ KV ++ K + E+R +E K ++EE+ R +E+ ++E++ +E +++
Sbjct: 578 KIREQEEKVWRQEEKIREQEEKRQEQEEKMWKQEEKIREQEEKIQEQEEKIREQEEKIRE 637
Query: 197 AQLHCQASEKEEREWEEQLRRSKAADEERSRRAQRARDEYR 237
+ Q E++ E EE++ + +E+ R ++ R
Sbjct: 638 QEEMTQEQEEKMGEQEEKMCEQEEKMQEQEETMWRQEEKIR 678
>gi|239745095 PREDICTED: hypothetical protein LOC645202 [Homo
sapiens]
Length = 570
Score = 60.8 bits (146), Expect = 2e-09
Identities = 59/247 (23%), Positives = 119/247 (48%), Gaps = 24/247 (9%)
Query: 30 KMREEQLRRWKE----RETWEALAQDEGLRPPKTKRAASDKHIQWLLGADGEVWVWIMGE 85
KMR ++ W++ RE E + + E +R + KR +K + + E +W E
Sbjct: 331 KMRRQEEMMWEKEEKIRELEEKMHEQEKIREQEEKRQEEEKIREQEKRQEQEAKMWRQEE 390
Query: 86 GPGDKPYEEI--SEELIAERARLQAQREAEELWRQKEAEITKKFRDALANEKARILAEKW 143
++ E+I EE++ E+ ++E E++W Q+E E+ ++ EK R EK
Sbjct: 391 KIREQE-EKIREQEEMMQEQEEKMGEQE-EKMWEQEE-EMQEQ------EEKMRRQEEKI 441
Query: 144 KVEMEDRKAAKVLEERIHEEFKRKEEEERKRGEEQIRL-QEEQRAKELYWTLKQAQLHCQ 202
+ E K + EE+I E+ + +E+E K GE++ ++ ++E + +E +++ + +
Sbjct: 442 R---EQEKKIREQEEKIREQEEMMQEQEEKMGEQEGKMCEQEAKMQEQEEKMRRQEEKIR 498
Query: 203 ASEKEEREWEEQLRRSKAADEERSRRAQRARDEYRHHSLRAIQKGTVAGLSSMFRELGQS 262
EK+ RE EE++R + +E+ + ++ + ++ M R+ +
Sbjct: 499 EQEKKIREQEEKIREQEEMMQEQEEKMWEQEEKMCEQEEKMQEQE-----EKMRRQEEKM 553
Query: 263 HEQEARL 269
EQE RL
Sbjct: 554 REQEVRL 560
Score = 60.1 bits (144), Expect = 3e-09
Identities = 50/214 (23%), Positives = 113/214 (52%), Gaps = 18/214 (8%)
Query: 30 KMREEQLRRWKERETWEALAQDEGLRPPKTKRAASDKHIQWLLGADGEVWVWIMGEGPGD 89
K+RE++ R+ +E + W Q+E +R + K ++ +Q GE + + +
Sbjct: 371 KIREQEKRQEQEAKMWR---QEEKIREQEEKIREQEEMMQEQEEKMGEQEEKMWEQ---E 424
Query: 90 KPYEEISEELIAERARLQAQ----REAEELWRQKEAEITKKFRDALANEKARILAEKWKV 145
+ +E E++ + +++ Q RE EE R++E E+ ++ + + ++ ++ ++ K+
Sbjct: 425 EEMQEQEEKMRRQEEKIREQEKKIREQEEKIREQE-EMMQEQEEKMGEQEGKMCEQEAKM 483
Query: 146 EMEDRKAAKVLEERIHEEFKRKEEEERKRGEEQIRLQEEQRAKELYWTLKQAQLHCQASE 205
+ ++ K + EE+I E+ K+ E+E K E++ +QE++ E W +Q + C+ E
Sbjct: 484 QEQEEKMRRQ-EEKIREQEKKIREQEEKIREQEEMMQEQE---EKMW--EQEEKMCEQEE 537
Query: 206 KEEREWEEQLRRSKAADEERSRRAQRARDEYRHH 239
K + E EE++RR + E+ R ++ ++ + H
Sbjct: 538 KMQ-EQEEKMRRQEEKMREQEVRLRQQEEKMQEH 570
Score = 58.5 bits (140), Expect = 9e-09
Identities = 56/228 (24%), Positives = 101/228 (44%), Gaps = 51/228 (22%)
Query: 93 EEISEELIAERARLQAQREAEELW------------RQKEAEITKKFRDALANEKARILA 140
+ + +EL + A+LQAQ E ELW RQ+E ++ + EK R
Sbjct: 256 DHLGKELQSVSAKLQAQVEENELWNRLNQQQEEKMWRQEEKIQEREEKIQEQEEKIREQE 315
Query: 141 EK--------WKVEMEDRKAAKV----------LEERIHEEFKRKEEEERKRGEEQIRLQ 182
EK W+ E + R+ ++ LEE++HE+ K +E+EE+++ EE+IR Q
Sbjct: 316 EKMRRQEEMMWEKEEKMRRQEEMMWEKEEKIRELEEKMHEQEKIREQEEKRQEEEKIREQ 375
Query: 183 EEQRAKELYWTLKQAQLHCQ-----------------ASEKEEREWEE----QLRRSKAA 221
E+++ +E ++ ++ Q E+EE+ WE+ Q + K
Sbjct: 376 EKRQEQEAKMWRQEEKIREQEEKIREQEEMMQEQEEKMGEQEEKMWEQEEEMQEQEEKMR 435
Query: 222 DEERSRRAQRARDEYRHHSLRAIQKGTVAGLSSMFRELGQSHEQEARL 269
+E R Q + + +R ++ M + G+ EQEA++
Sbjct: 436 RQEEKIREQEKKIREQEEKIREQEEMMQEQEEKMGEQEGKMCEQEAKM 483
>gi|222446603 golgi autoantigen, golgin subfamily a-like [Homo
sapiens]
Length = 668
Score = 60.1 bits (144), Expect = 3e-09
Identities = 44/176 (25%), Positives = 95/176 (53%), Gaps = 10/176 (5%)
Query: 93 EEISEELIAERARLQAQREAEELWRQKEAEITKKFRDALANEKARILAEKWKVEMEDRKA 152
E+I E+ R + + R EE+ +KE ++ ++ + + EK + ++ E +
Sbjct: 321 EKIREQEEKIREQEEKMRRQEEMMWEKEEKMRRQ--EEMMWEKEEKMRRLEEMMWEKEEK 378
Query: 153 AKVLEERIHEEFKRKEEEERKRGEEQIRLQEEQRAKELYWTLKQAQLHCQASEKEEREWE 212
+ LEE++HE+ K +E+EE+++ EE+IR QE+++ +E ++ ++ Q E++ RE E
Sbjct: 379 IRELEEKMHEQEKIREQEEKRQEEEKIREQEKRQEQEAKMWRQEEKIREQ--EEKIREQE 436
Query: 213 EQLRRSKAADEERSRRAQRARDEYRHHSLRAI--QKGTVAGLSSMFRELGQSHEQE 266
+++ R EE+ ++ R+E + + Q+ + ++R+ + HEQE
Sbjct: 437 KKMWR----QEEKIHEQEKIREEEKRQEQEEMWRQEEKIREQEEIWRQKEKMHEQE 488
Score = 58.9 bits (141), Expect = 7e-09
Identities = 61/260 (23%), Positives = 120/260 (46%), Gaps = 33/260 (12%)
Query: 30 KMREEQLRRWKERETWEALAQDEGLRPPKTKRAASDKHIQWLLGADGEVWVWIMGEGPGD 89
K+RE++ R+ +E + W Q+E +R + K +K ++W +
Sbjct: 404 KIREQEKRQEQEAKMWR---QEEKIREQEEKIREQEK----------KMWRQEEKIHEQE 450
Query: 90 KPYEEISEELIAERARLQAQ-REAEELWRQKEA----EITKKFRDAL---------ANEK 135
K EE + E R + + RE EE+WRQKE E +K + + EK
Sbjct: 451 KIREEEKRQEQEEMWRQEEKIREQEEIWRQKEKMHEQEKIRKQEEKVWRQEEKMHDQEEK 510
Query: 136 ARILAEK-WKVEMEDRKAAKVL---EERIHEEFKRKEEEERKRGEEQIRLQEEQRAKELY 191
R EK W+ E + R+ + + EE+I E+ + +E+E K GE++ ++QE+++ +
Sbjct: 511 IREQEEKMWRQEEKIREQEEKIREQEEKIREQEEMMQEQEEKMGEQEEKMQEQEKMRRQE 570
Query: 192 WTLKQAQLHCQASEKEEREWEEQL--RRSKAADEERSRRAQRARDEYRHHSLRAIQKGTV 249
+++ + + +++ RE EE++ + K ++E + Q + + + ++
Sbjct: 571 EKIREQEEKIREQKEKIREQEEKIWEQEEKIREQEEMMQEQEEKMWEQEEKMCEQEEKMQ 630
Query: 250 AGLSSMFRELGQSHEQEARL 269
M R+ + EQE RL
Sbjct: 631 EQEEKMRRQEEKMWEQEVRL 650
Score = 57.8 bits (138), Expect = 1e-08
Identities = 48/206 (23%), Positives = 103/206 (50%), Gaps = 11/206 (5%)
Query: 32 REEQLRRWKE--RETWEALAQDEGLRPPKTKRAASDKHIQWLLGADGEVWVWIMGEGPGD 89
+EE++R +E RE E + + E + K ++ + + W +M E +
Sbjct: 319 QEEKIREQEEKIREQEEKMRRQEEMMWEKEEKMRRQEEMMWEKEEKMRRLEEMMWEK--E 376
Query: 90 KPYEEISEELIAERARLQAQREAEELWRQKEAEITKKFRDALANEKARILAEKWKVEMED 149
+ E+ E++ + + + + +E + +E E ++ + ++ +I ++ K+ ++
Sbjct: 377 EKIRELEEKMHEQEKIREQEEKRQEEEKIREQEKRQEQEAKMWRQEEKIREQEEKIREQE 436
Query: 150 RKAAKVLEERIHEEFKRKEEEERKRGEEQIRLQEEQRAKELYWTLKQAQLHCQAS--EKE 207
+K + EE+IHE+ K +EEE+R+ EE R +E+ R +E W K+ ++H Q ++E
Sbjct: 437 KKMWRQ-EEKIHEQEKIREEEKRQEQEEMWRQEEKIREQEEIWRQKE-KMHEQEKIRKQE 494
Query: 208 EREWEEQLRRSKAADEERSRRAQRAR 233
E+ W ++ K D+E R Q +
Sbjct: 495 EKVWRQE---EKMHDQEEKIREQEEK 517
Score = 55.8 bits (133), Expect = 6e-08
Identities = 60/229 (26%), Positives = 114/229 (49%), Gaps = 25/229 (10%)
Query: 30 KMREEQLRRWKERETW---EALAQDEGLRPPKTKRAASDKHIQWLLGADGEVWVWIMGEG 86
K+REE+ +R ++ E W E + + E + K K +K + + +VW
Sbjct: 451 KIREEE-KRQEQEEMWRQEEKIREQEEIWRQKEKMHEQEK----IRKQEEKVWRQEEKMH 505
Query: 87 PGDKPYEEISEELIAERARLQAQ----REAEELWRQKEAEITKKFRDALANEKARILAEK 142
++ E E++ + +++ Q RE EE R++E E+ ++ + + ++ + + E+
Sbjct: 506 DQEEKIREQEEKMWRQEEKIREQEEKIREQEEKIREQE-EMMQEQEEKMGEQEEK-MQEQ 563
Query: 143 WKVEMEDRKAAKVLEERIHEEFKRKEEEERK--RGEEQIRLQEE--QRAKELYWTLKQAQ 198
K+ ++ K + EE+I E+ ++ E+E K EE+IR QEE Q +E W +Q +
Sbjct: 564 EKMRRQEEKIREQ-EEKIREQKEKIREQEEKIWEQEEKIREQEEMMQEQEEKMW--EQEE 620
Query: 199 LHCQASEKEEREWEEQLRRSKA---ADEERSRRAQRARDEYRHHSLRAI 244
C+ EK + E EE++RR + E R R+ + E++ H AI
Sbjct: 621 KMCEQEEKMQ-EQEEKMRRQEEKMWEQEVRLRQQEEKMQEHQEHLEAAI 668
Score = 54.7 bits (130), Expect = 1e-07
Identities = 42/191 (21%), Positives = 94/191 (49%), Gaps = 25/191 (13%)
Query: 93 EEISEELIAERARLQAQREAEELWRQ----------KEAEITKKFRDALANEKARILAEK 142
+ + +EL + A+LQAQ E ELW + ++ E +++ + + ++ +I ++
Sbjct: 268 DHLGKELQSVSAKLQAQVEENELWNRLNQQQEEKMWRQEEKIQEWEEKIQEQEEKIREQE 327
Query: 143 WKVEMEDRKAAKVLEERIHEEFKRK-------EEEERKRGEEQIRLQEEQRAKELYWTLK 195
K+ ++ K + E +E K + E+EE+ R E++ ++E++ +EL
Sbjct: 328 EKIREQEEKMRRQEEMMWEKEEKMRRQEEMMWEKEEKMRRLEEMMWEKEEKIREL----- 382
Query: 196 QAQLHCQASEKEEREWEEQLRRSKAADEERSRRAQRARDEYRHHSLRAIQKGTVAGLSSM 255
+ ++H +++ RE EE+ + + E+ R+ Q A+ + +R ++ M
Sbjct: 383 EEKMH---EQEKIREQEEKRQEEEKIREQEKRQEQEAKMWRQEEKIREQEEKIREQEKKM 439
Query: 256 FRELGQSHEQE 266
+R+ + HEQE
Sbjct: 440 WRQEEKIHEQE 450
Score = 37.4 bits (85), Expect = 0.021
Identities = 44/186 (23%), Positives = 88/186 (47%), Gaps = 28/186 (15%)
Query: 97 EELIAERARLQAQREAEELWRQKEAEITKKFRDALANEKARILAEKWKVEMED------- 149
EEL + A+LQ + + E + + K+ + L E+A++L + +++ E
Sbjct: 217 EELKEKNAKLQEKLQLVESEKSEIQLNVKELKRKL--ERAKLLLPQQQLQAEADHLGKEL 274
Query: 150 -----RKAAKVLEERIHEEFKRKEEEERKRGEEQIRLQEEQRAKELYWTLKQAQLHCQAS 204
+ A+V E + +++EE+ R EE+I+ EE+ +++ + +
Sbjct: 275 QSVSAKLQAQVEENELWNRLNQQQEEKMWRQEEKIQEWEEK--------IQEQEEKIREQ 326
Query: 205 EKEEREWEEQLRRSKA---ADEERSRRAQRARDEYRHHSLRAIQKGTVAGLSSMFRELGQ 261
E++ RE EE++RR + EE+ RR + E + +R +++ + REL +
Sbjct: 327 EEKIREQEEKMRRQEEMMWEKEEKMRRQEEMMWE-KEEKMRRLEE-MMWEKEEKIRELEE 384
Query: 262 S-HEQE 266
HEQE
Sbjct: 385 KMHEQE 390
>gi|239756241 PREDICTED: golgi autoantigen, golgin subfamily a-like
[Homo sapiens]
Length = 899
Score = 58.5 bits (140), Expect = 9e-09
Identities = 57/253 (22%), Positives = 111/253 (43%), Gaps = 21/253 (8%)
Query: 30 KMREEQLRRWKERETWEALAQDEGLRPPKTKRAASDKHIQWLLGADGEVWVWIMGEGPGD 89
K+ E++ + +E + WE Q+E +R + K + + E +W E D
Sbjct: 499 KLWEQEKMQEQEEKIWE---QEEKIRDQEEMWGQEKKMWRQEKMREQEDQMWEQEEKMRD 555
Query: 90 KPYEEISEELIAERARLQAQREAEELWRQKEA--------EITKKFRDA--LANEKARIL 139
+ + +E ER + Q + ++ W Q+E E KK R+ + E+ +
Sbjct: 556 QEQKMWDQE---ERMEKKTQEQEKKTWDQEEKMREEERMREREKKMREEEEMMREQEEKM 612
Query: 140 AEKWKVEMEDRKAAKVLEERIHEEFKRKEEEERKRGEEQIRLQEEQR---AKELYWTLKQ 196
E+ + E + EE++ E+ ++ E+E K E++ ++ E+QR KE W ++
Sbjct: 613 QEQEEKMQEQEEKMWEQEEKMQEQEEKMWEQEEKMWEQEEKMWEQQRLPEQKEKLWEHEK 672
Query: 197 AQLHCQASEKEEREWEEQLRRSKAADEERSRRAQRARDEYRHHSLRAIQKGTVAGLSSMF 256
Q + E+EE+ WE++ K ++E+ Q E S+R +K M
Sbjct: 673 MQEQEKMQEQEEKIWEQEKMEKKTQEQEKKTWDQEKMRE--EESMREREKKMREEEEMMR 730
Query: 257 RELGQSHEQEARL 269
+ + EQE ++
Sbjct: 731 EQEEKMQEQEEKM 743
Score = 51.6 bits (122), Expect = 1e-06
Identities = 59/270 (21%), Positives = 116/270 (42%), Gaps = 36/270 (13%)
Query: 30 KMREEQLRRWKE---RETWEALAQDEGLRPPKTKRAASDKHIQW-----LLGADGEVW-- 79
KMREE+ R +E RE E + + E + ++ + W + + ++W
Sbjct: 584 KMREEERMREREKKMREEEEMMREQEEKMQEQEEKMQEQEEKMWEQEEKMQEQEEKMWEQ 643
Query: 80 ---VWIMGEGPGDKPYEEISEELIAERARLQAQREAEE----LWRQKEAEITKKFRDALA 132
+W E ++ +E + E ++Q Q + +E +W Q++ E KK ++
Sbjct: 644 EEKMWEQEEKMWEQQRLPEQKEKLWEHEKMQEQEKMQEQEEKIWEQEKME--KKTQE--- 698
Query: 133 NEKARILAEKWKVEMEDRKAAKVLEERIHEEFKRKEEEERKRGEEQIRLQEEQ--RAKEL 190
EK EK + E R+ K + E EE R++EE+ + EE+++ QEE+ +E
Sbjct: 699 QEKKTWDQEKMREEESMREREKKMRE--EEEMMREQEEKMQEQEEKMQEQEEEMWEQEEK 756
Query: 191 YWTLKQAQLHCQ-ASEKEEREWEEQL---------RRSKAADEERSRRAQRARDEYRHHS 240
W ++ Q E++E+ WE + + K D+E R Q + +
Sbjct: 757 MWEQEEKMWEQQRLPEQKEKLWEHEKMQEQEKIWEQEEKMRDQEEKMRGQEEKMRGQEEK 816
Query: 241 LRAIQKGTVAGLSSMFRELGQSHEQEARLY 270
+R ++ M+ + + QE +++
Sbjct: 817 MRGQEEKMWGQEEKMWGQEEKMWGQEEKMW 846
Score = 50.4 bits (119), Expect = 2e-06
Identities = 57/222 (25%), Positives = 105/222 (47%), Gaps = 29/222 (13%)
Query: 30 KMRE-EQLRRWKERETWEALAQDEGLRPPKTKRAASDKHIQWLLGADGEVWVWIMGEGPG 88
+MRE EQ R +E WE QDE LR + + +K + + E + +
Sbjct: 384 QMREQEQKMRDQEERMWE---QDERLREKEERMREQEKMWEQVEKMREEKKMQEQEKKTR 440
Query: 89 DKPYEEISEELIAERARLQAQREAEELWRQKEAEITKKFRDALANEKARILAEKWKVEME 148
D+ + EE I ER + RE EE R++E ++ K+ + E+ ++W+ +
Sbjct: 441 DQEEKMQEEERIREREK--KMREEEETMREQEEKMQKQEENMWEQEE-----KEWQQQRL 493
Query: 149 DRKAAKVLEERIHEEFKRKEEEERK-RGEEQIRLQEEQ--RAKELYWTLKQAQLHCQASE 205
+ +E++ E+ K +E+EE+ EE+IR QEE + K+++ K + Q E
Sbjct: 494 PEQ-----KEKLWEQEKMQEQEEKIWEQEEKIRDQEEMWGQEKKMWRQEKMREQEDQMWE 548
Query: 206 KEE-------REWEEQLRRSKAADEERSR---RAQRARDEYR 237
+EE + W+++ R K E+ + + ++ R+E R
Sbjct: 549 QEEKMRDQEQKMWDQEERMEKKTQEQEKKTWDQEEKMREEER 590
Score = 48.1 bits (113), Expect = 1e-05
Identities = 42/210 (20%), Positives = 102/210 (48%), Gaps = 19/210 (9%)
Query: 30 KMREEQLRRWKERETWEALAQDEGLRPPKTKRAASDKHIQWLLGADGEVWVWIMGEGPGD 89
KM+EE+ R +E++ E ++E +R + K ++++ W + E W P
Sbjct: 445 KMQEEERIREREKKMRE---EEETMREQEEKMQKQEENM-W----EQEEKEWQQQRLPEQ 496
Query: 90 KPYEEISEELIAERARLQAQ----REAEELWRQKEAEITKKFRDALANEKARILAEKWKV 145
K E++ + ++ Q R+ EE+W Q++ K +R E+ + W+
Sbjct: 497 KEKLWEQEKMQEQEEKIWEQEEKIRDQEEMWGQEK----KMWRQEKMREQED---QMWEQ 549
Query: 146 EMEDRKAAKVLEERIHEEFKRKEEEERKRGEEQIRLQEEQRAKELYWTLKQAQLHCQASE 205
E + R + + ++ K+ +E+E+K +++ +++EE+R +E +++ + + E
Sbjct: 550 EEKMRDQEQKMWDQEERMEKKTQEQEKKTWDQEEKMREEERMREREKKMREEEEMMREQE 609
Query: 206 KEEREWEEQLRRSKAADEERSRRAQRARDE 235
++ +E EE+++ + E+ + Q ++
Sbjct: 610 EKMQEQEEKMQEQEEKMWEQEEKMQEQEEK 639
Score = 47.8 bits (112), Expect = 2e-05
Identities = 48/247 (19%), Positives = 114/247 (46%), Gaps = 25/247 (10%)
Query: 30 KMREEQLRRWKERETWEALAQDEG-LRPPKTKRAASDKHIQWLLGADGEVWVWIMGEGPG 88
K+R+++ + W++ E L + EG +R + K +K ++ E
Sbjct: 287 KIRKQEEKMWRQEER---LREQEGKMREQEEKMWRQEKRLR-------------EQEKEL 330
Query: 89 DKPYEEISEELIAERARLQAQREAEELWRQKEAEITKKFRDALANEKARILAEKWKVEME 148
+ +E+ E+ Q Q + E++W Q+E ++ + + ++ R+ ++ ++ +
Sbjct: 331 REQEKELREQKELREQEEQMQEQEEKMWEQEEK--MREQEEKMWRQEERLWEQEKQMREQ 388
Query: 149 DRKAAKVLEERIHEEFKR-KEEEERKRGEEQIRLQEEQRAKELYWTLKQAQLHCQASEKE 207
++K + EER+ E+ +R +E+EER R +E++ Q E+ +E ++ + Q + +
Sbjct: 389 EQKM-RDQEERMWEQDERLREKEERMREQEKMWEQVEKMREEKKMQEQEKKTRDQEEKMQ 447
Query: 208 E----REWEEQLRRSKAADEERSRRAQRARDEYRHHSLRAIQKGTVAGLSSMFRELGQSH 263
E RE E+++R + E+ + Q+ + + Q+ + E +
Sbjct: 448 EEERIREREKKMREEEETMREQEEKMQKQEENMWEQEEKEWQQQRLPEQKEKLWEQEKMQ 507
Query: 264 EQEARLY 270
EQE +++
Sbjct: 508 EQEEKIW 514
Score = 46.2 bits (108), Expect = 4e-05
Identities = 53/209 (25%), Positives = 97/209 (46%), Gaps = 51/209 (24%)
Query: 30 KMREEQLRRWKERET-WEALAQDEGLRPPKTKRAASDKHIQWLLGADGEVWVWIMGEGPG 88
KMRE++ + W++ E WE Q++ +R + K D E +W
Sbjct: 363 KMREQEEKMWRQEERLWE---QEKQMREQEQKMR------------DQEERMW------- 400
Query: 89 DKPYEEISEELIAERARLQAQREAEELWRQKEAEITKKFRDALANEKARILAEKWKVEME 148
E E L R + + RE E++W Q E K R E+ ++ ++ K +
Sbjct: 401 -----EQDERL---REKEERMREQEKMWEQVE-----KMR-----EEKKMQEQEKKTRDQ 442
Query: 149 DRKAAKVLEERIHEEFK--RKEEEERKRGEEQIRLQEEQRAKELYWTLKQAQLHCQASEK 206
+ K + EERI E K R+EEE + EE+++ QEE ++ +Q +L E+
Sbjct: 443 EEKMQE--EERIREREKKMREEEETMREQEEKMQKQEENMWEQEEKEWQQQRL----PEQ 496
Query: 207 EEREWEEQLRRSKAADEERSRRAQRARDE 235
+E+ WE++ + + +E+ + ++ RD+
Sbjct: 497 KEKLWEQE--KMQEQEEKIWEQEEKIRDQ 523
Score = 45.8 bits (107), Expect = 6e-05
Identities = 40/177 (22%), Positives = 84/177 (47%), Gaps = 13/177 (7%)
Query: 97 EELIAERARLQAQREAEELWRQKEAEITKKFRDALANEKARILAEK-WKVEMEDRKAAKV 155
EEL + +++ Q E ++WRQ+E + R+ K R EK W+ E R+ K
Sbjct: 279 EELREQEKKIRKQEE--KMWRQEE-----RLREQ--EGKMREQEEKMWRQEKRLREQEKE 329
Query: 156 LEER---IHEEFKRKEEEERKRGEEQIRLQEEQRAKELYWTLKQAQLHCQASEKEEREWE 212
L E+ + E+ + +E+EE+ + +E+ ++E++ +E + + + EK+ RE E
Sbjct: 330 LREQEKELREQKELREQEEQMQEQEEKMWEQEEKMREQEEKMWRQEERLWEQEKQMREQE 389
Query: 213 EQLRRSKAADEERSRRAQRARDEYRHHSLRAIQKGTVAGLSSMFRELGQSHEQEARL 269
+++R + E+ R + + R Q + M + ++ +QE ++
Sbjct: 390 QKMRDQEERMWEQDERLREKEERMREQEKMWEQVEKMREEKKMQEQEKKTRDQEEKM 446
Score = 45.1 bits (105), Expect = 1e-04
Identities = 43/149 (28%), Positives = 79/149 (53%), Gaps = 21/149 (14%)
Query: 89 DKPYEEISEELIAERARLQAQ----REAEE-LWRQKEAEITKKFRDALANEKARILAEKW 143
+K + E++ + RL+ Q RE EE +WRQ+ K+ R E+ + L E+
Sbjct: 285 EKKIRKQEEKMWRQEERLREQEGKMREQEEKMWRQE-----KRLR-----EQEKELREQE 334
Query: 144 KVEMEDRKAAKVLEERIHE-EFKRKEEEERKRGEEQIRLQEEQRAKELYWTLKQAQLHCQ 202
K E+ ++K + EE++ E E K E+EE+ R +E+ ++E+R E +++ + +
Sbjct: 335 K-ELREQKELREQEEQMQEQEEKMWEQEEKMREQEEKMWRQEERLWEQEKQMREQEQ--K 391
Query: 203 ASEKEEREWEEQLRRSKAADEERSRRAQR 231
++EER WE+ R + EER R ++
Sbjct: 392 MRDQEERMWEQDERLRE--KEERMREQEK 418
Score = 44.3 bits (103), Expect = 2e-04
Identities = 47/199 (23%), Positives = 92/199 (46%), Gaps = 20/199 (10%)
Query: 89 DKPYEEISEELIAERARLQAQREAEELWRQKEAEITKKFRDALANEKARILAEKWKVEME 148
D+ EE+++E A L E ++K AE+ +K A +EK+ I +++ +
Sbjct: 196 DRYIEELTKERDALSLELYRNTITNEELKKKNAELQEKLPLA-ESEKSEIQLNVKELKRK 254
Query: 149 DRKAAKVL---------------EERIHEEFK--RKEEEERKRGEEQIRLQEEQRAKELY 191
+A +L EE + E+ K RK+EE+ R EE++R ++E + +E
Sbjct: 255 LERAKFLLPQVQTNTLQEEMWRQEEELREQEKKIRKQEEKMWRQEERLR-EQEGKMREQE 313
Query: 192 WTLKQAQLHCQASEKEEREWEEQLRRSK-AADEERSRRAQRARDEYRHHSLRAIQKGTVA 250
+ + + + EKE RE E++LR K ++E + Q + + +R ++
Sbjct: 314 EKMWRQEKRLREQEKELREQEKELREQKELREQEEQMQEQEEKMWEQEEKMREQEEKMWR 373
Query: 251 GLSSMFRELGQSHEQEARL 269
++ + Q EQE ++
Sbjct: 374 QEERLWEQEKQMREQEQKM 392
Score = 40.4 bits (93), Expect = 0.002
Identities = 37/181 (20%), Positives = 85/181 (46%), Gaps = 19/181 (10%)
Query: 107 QAQREAEELWRQKEAEITKKFRDALANEKARI----LAEKWKVEMEDRKAAKVLEERIHE 162
+A R EEL ++++A + +R+ + NE+ + L EK + ++ ++ + +
Sbjct: 194 KADRYIEELTKERDALSLELYRNTITNEELKKKNAELQEKLPLAESEKSEIQLNVKELKR 253
Query: 163 EFKRKE-----------EEERKRGEEQIRLQEE--QRAKELYWTLKQAQLHCQASEKEER 209
+ +R + +EE R EE++R QE+ ++ +E W ++ +L Q + E+
Sbjct: 254 KLERAKFLLPQVQTNTLQEEMWRQEEELREQEKKIRKQEEKMWR-QEERLREQEGKMREQ 312
Query: 210 EWEEQLRRSKAADEERSRRAQRARDEYRHHSLRAIQKGTVAGLSSMFRELGQSHEQEARL 269
E E+ R+ K E+ ++ ++ LR ++ M+ + + EQE ++
Sbjct: 313 E-EKMWRQEKRLREQEKELREQEKELREQKELREQEEQMQEQEEKMWEQEEKMREQEEKM 371
Query: 270 Y 270
+
Sbjct: 372 W 372
Score = 40.0 bits (92), Expect = 0.003
Identities = 46/185 (24%), Positives = 84/185 (45%), Gaps = 38/185 (20%)
Query: 30 KMREEQLRRWKERETWEALAQDEGLRPPKTKRAASDKHIQWLLGADGEVW-----VWIMG 84
KMREE+ R +E++ E ++E +R + K ++ +Q + E+W +W
Sbjct: 708 KMREEESMREREKKMRE---EEEMMREQEEKMQEQEEKMQ---EQEEEMWEQEEKMWEQE 761
Query: 85 EGPGDKPYEEISEELIAERARLQAQREAEELWRQKEAEITKKFRDALANEKARILAEK-- 142
E ++ +E + E ++Q Q E++W Q+E ++ + EK R EK
Sbjct: 762 EKMWEQQRLPEQKEKLWEHEKMQEQ---EKIWEQEEKMRDQEEKMRGQEEKMRGQEEKMR 818
Query: 143 --------------------WKVEMEDRKAAKVLEERIH-EEFKRKEEEERKRG-EEQIR 180
W E + + +EE++ +E K +E+EE+ RG EE++R
Sbjct: 819 GQEEKMWGQEEKMWGQEEKMWGQEEKMWGQEEKMEEKMQGQEEKMREQEEKMRGQEEKMR 878
Query: 181 LQEEQ 185
QEE+
Sbjct: 879 EQEEK 883
>gi|221219020 NYD-SP11 protein [Homo sapiens]
Length = 2873
Score = 57.8 bits (138), Expect = 1e-08
Identities = 46/204 (22%), Positives = 92/204 (45%), Gaps = 26/204 (12%)
Query: 37 RRWKERETWEALAQDEGLRP------PKTKRAASDKHIQWLLGADGEVWVWIMGEGPGDK 90
+ WKE L ++E L P+ + DK ++W E W
Sbjct: 1479 KAWKEEWEKRLLQEEEKLHQAGEKLSPEEEMLQEDKKLKW------EEW----------- 1521
Query: 91 PYEEISEELIAERARLQAQREAEELWRQKEAEITKKFRDALANEKARILAEKWKVEMEDR 150
+++ E +++ +++ Q ++ EE+ ++E + ++ E+ R + E+ K R
Sbjct: 1522 --KQVWENMLSSKSKEQQYKDEEEVTLEEEVSREGEEKEQQVTEEQRHIQEEHKWARIHR 1579
Query: 151 KAAKVLEERIHEEFKRKEEEERKRGEEQIRLQEEQRAKELYWTLKQAQLHCQASEKEERE 210
K A+ ++R EE K +EEE+ EE+ QEE++ + Y + Q +E + +
Sbjct: 1580 KRARAEKKRAQEERKLAQEEEKLAQEERQLAQEERKLAQAYVKITQDDREMAQAEGKFAQ 1639
Query: 211 WEEQL-RRSKAADEERSRRAQRAR 233
EE L +R + +E + AQ+ +
Sbjct: 1640 KEETLAQRGEKLSQEAEKLAQKRK 1663
Score = 44.7 bits (104), Expect = 1e-04
Identities = 42/164 (25%), Positives = 77/164 (46%), Gaps = 9/164 (5%)
Query: 88 GDKPYEEISEELIAERARLQAQREAEELWRQ--KEAEITKKFRDALANEKARILAEKWKV 145
GDKP E+ S ++ + E E L + K+ ++ + + E+ R E+ +
Sbjct: 2206 GDKPKEKFSSQVDEVESEEHFSEEMESLLDELEKQESLSSEEEEEREEEEERE-EEEVRE 2264
Query: 146 EMEDRKAAKVLEERI---HEEFKRKEEEERKRGEEQIRLQEEQRAKELYWTLKQAQLHCQ 202
E E+RK + EE+ EE K+K+++E+K+ E Q + + + +E+ + L +
Sbjct: 2265 EEEERKEEEEGEEKQVEKEEEEKKKKKKEKKKEEVQEKEEVFEEKEEIMSEEETESLSDE 2324
Query: 203 ASEKEEREWEEQLRRSKAADEERSRRAQRARDEYRHHSLRAIQK 246
E+E EE++ R K E + Q E R SLR ++
Sbjct: 2325 EEEEESCSLEEEVDREK---EILKKEKQFKLQEQRRKSLRGRER 2365
Score = 43.5 bits (101), Expect = 3e-04
Identities = 32/122 (26%), Positives = 61/122 (50%), Gaps = 9/122 (7%)
Query: 116 WRQ-KEAEITKKFRDALANEKARILAEK-WKVEMEDRKAAKVLEERIHEEFKRKEEEERK 173
WR+ KEA+ K ++ +++ + +E+ + EME +E + E + + EEE +
Sbjct: 2197 WRKRKEAKRGDKPKEKFSSQVDEVESEEHFSEEMESLLDELEKQESLSSEEEEEREEEEE 2256
Query: 174 RGEEQIRLQEEQRAKELYWTLKQAQLHCQASEKEEREWEEQLRRSKAADEERSRRAQRAR 233
R EE++R +EE+R +E KQ EKEE E +++ + K + + +
Sbjct: 2257 REEEEVREEEEERKEEEEGEEKQV-------EKEEEEKKKKKKEKKKEEVQEKEEVFEEK 2309
Query: 234 DE 235
+E
Sbjct: 2310 EE 2311
Score = 39.3 bits (90), Expect = 0.005
Identities = 51/245 (20%), Positives = 98/245 (40%), Gaps = 37/245 (15%)
Query: 81 WIMGEGPGDKPYEEISEELIAERARLQAQREAEELWRQKEAEITKKFRDALANEKARILA 140
W G K ++ EE E+ LQ + + + + E + + E ++
Sbjct: 1467 WKQVHGETRKSWKAWKEEW--EKRLLQEEEKLHQAGEKLSPE------EEMLQEDKKLKW 1518
Query: 141 EKWKVEMEDRKAAKVLEER--------IHEEFKRK-EEEERKRGEEQIRLQEEQRAKELY 191
E+WK E+ ++K E++ + EE R+ EE+E++ EEQ +QEE + ++
Sbjct: 1519 EEWKQVWENMLSSKSKEQQYKDEEEVTLEEEVSREGEEKEQQVTEEQRHIQEEHKWARIH 1578
Query: 192 WTLKQAQLHCQASEKEEREWEEQLRRSKAADEERSRRAQRARDEYRHHSLRAIQ-KGTVA 250
+A+ E++ + EE+L + + + R+ +A + Q +G A
Sbjct: 1579 RKRARAEKKRAQEERKLAQEEEKLAQEERQLAQEERKLAQAYVKITQDDREMAQAEGKFA 1638
Query: 251 GLSSMFRELGQSHEQEARLYHHLPDPGLPQPLALPVRTWERPLRPVSRDVIVRWFKEEQL 310
+ G+ QEA L Q + WE+ R +EE+L
Sbjct: 1639 QKEETLAQRGEKLSQEAE--------KLAQKRKKLAKKWEKVAR-----------EEEKL 1679
Query: 311 PRRAG 315
++ G
Sbjct: 1680 AKKGG 1684
Score = 38.9 bits (89), Expect = 0.007
Identities = 32/142 (22%), Positives = 71/142 (50%), Gaps = 14/142 (9%)
Query: 95 ISEELIAERARLQAQREAE----ELWRQKEAEITKKFRDALANEKARILAEKWKVEMEDR 150
+ E+++ R+ A E+E +L + I + + LA +++ ++ + E
Sbjct: 2012 LEEKILLHEDRILAMEESEIAKGKLEFTRGQRIFVQGQRKLAKASRKLIKKRESLSKEPA 2071
Query: 151 KAAKVLEERIHEEFKRKEEEERKRGEEQIRLQEEQRAKELYWTLKQAQLHCQASEKEERE 210
K K+L+ ++ +ERK +E+I++ + +RA +K+ +L + S+ + +E
Sbjct: 2072 KLNKILKA-----LQKLTRDERKLTQEEIKMTKMKRAL----FVKERRLSIEQSKLDIKE 2122
Query: 211 WEEQLRRSK-AADEERSRRAQR 231
W+ +RS+ DE++ R QR
Sbjct: 2123 WDFSEKRSELTKDEKKLARKQR 2144
Score = 38.5 bits (88), Expect = 0.009
Identities = 44/183 (24%), Positives = 81/183 (44%), Gaps = 18/183 (9%)
Query: 97 EELIAERARLQAQREAEELWRQKEA----EITKKFRDALANEKARILAEKWKVEMEDRKA 152
+ ++A++ QRE W++KE E + + L+ ++ + E+ K+ E +K
Sbjct: 1690 KNILAQKVEELPQREQNLDWQEKELAQELEELEWDMEELSWKEEELNQEEGKLVEEKKKL 1749
Query: 153 AKVLEERIHEEFKRKEEEERKRGEEQIRLQEEQRAKELYWTLKQAQLHCQASEKEER--E 210
A+ E + K EEE + EE++ +QE++ K AQ + E+EER
Sbjct: 1750 AEEEEALAWQREKLSEEETKLAQEEELLIQEKE---------KLAQHKEKMPEEEERLGR 1800
Query: 211 WEEQLRRSKAADEERSRRAQRARDEYRHHSLRAIQKGTVAGLSSMFRELGQSHEQEARLY 270
EQL K ++ R + +E + + QK L+ + L Q E+ A+
Sbjct: 1801 KREQLIEKKMKLAQKRERWINSMEELTKNKMILYQK---KNLAQEKKNLAQEKEKLAQRK 1857
Query: 271 HHL 273
+L
Sbjct: 1858 ENL 1860
Score = 35.4 bits (80), Expect = 0.079
Identities = 41/170 (24%), Positives = 79/170 (46%), Gaps = 14/170 (8%)
Query: 111 EAEELWRQKEAEITKKFRDALANE------KARILAEKW-KVEMEDRKAAKVLEERIH-E 162
+AE + QKE + ++ + L+ E K + LA+KW KV E+ K AK + +
Sbjct: 1632 QAEGKFAQKEETLAQR-GEKLSQEAEKLAQKRKKLAKKWEKVAREEEKLAKKGGKLAEVK 1690
Query: 163 EFKRKEEEERKRGEEQIRLQEEQRAKEL---YWTLKQAQLHCQASEKEEREWEEQLRRSK 219
++ EE + E+ + QE++ A+EL W +++ + +EE + E+ + K
Sbjct: 1691 NILAQKVEELPQREQNLDWQEKELAQELEELEWDMEELSWKEEELNQEEGKLVEE--KKK 1748
Query: 220 AADEERSRRAQRARDEYRHHSLRAIQKGTVAGLSSMFRELGQSHEQEARL 269
A+EE + QR + L ++ + + + + E+E RL
Sbjct: 1749 LAEEEEALAWQREKLSEEETKLAQEEELLIQEKEKLAQHKEKMPEEEERL 1798
Score = 30.4 bits (67), Expect = 2.5
Identities = 27/153 (17%), Positives = 67/153 (43%), Gaps = 19/153 (12%)
Query: 105 RLQAQREAEELWRQKEAEITKKFRDALANEKARILAEKWKVEMEDRKAAKVLEERIHEEF 164
+++ + EE +E E + + ++ +++ + +D K A +++H E
Sbjct: 1415 KIKREMTKEERDMSEEVEEMATLEEKVVKQEGKLVMIERTPSWQDWKKAWDEWKQVHGET 1474
Query: 165 KRKEEEERKRGEEQIRLQEE----------------QRAKELYW-TLKQAQLHCQASEKE 207
++ + ++ E+++ +EE Q K+L W KQ + +S+ +
Sbjct: 1475 RKSWKAWKEEWEKRLLQEEEKLHQAGEKLSPEEEMLQEDKKLKWEEWKQVWENMLSSKSK 1534
Query: 208 EREW--EEQLRRSKAADEERSRRAQRARDEYRH 238
E+++ EE++ + E + Q+ +E RH
Sbjct: 1535 EQQYKDEEEVTLEEEVSREGEEKEQQVTEEQRH 1567
>gi|169218106 PREDICTED: hypothetical protein, partial [Homo
sapiens]
Length = 436
Score = 57.8 bits (138), Expect = 1e-08
Identities = 45/186 (24%), Positives = 88/186 (47%), Gaps = 14/186 (7%)
Query: 97 EELIAERARLQAQREAEELWRQ-----KEAEITKKFRDALANEKARILAEKWKVEMEDRK 151
EE + E+ Q Q++ E++ +Q K+ E ++ + + ++ ++L +K + E E++
Sbjct: 233 EEQMGEQEE-QVQKQEEQVQKQEEQMRKQEEQMREQEEQMREQEEQMLKQKEQTEQEEQT 291
Query: 152 AAKVLEERIHEEFKRKEEEERKRGEEQIRLQEEQRAK--ELYWTLKQ------AQLHCQA 203
+ + R EE R++EE+ + EEQ+R QEEQ K E W K+ Q+ Q
Sbjct: 292 GEQEEQMREQEEQMREQEEQMREQEEQMREQEEQMGKQEEQMWEQKEQMWEQKEQMWKQE 351
Query: 204 SEKEEREWEEQLRRSKAADEERSRRAQRARDEYRHHSLRAIQKGTVAGLSSMFRELGQSH 263
+ E+E + Q + + +E R Q + + +R ++ M + Q
Sbjct: 352 EQMGEQEEQMQKQEEQVRKQEEQMRKQEEQMRKQEEQMRKQEEQMGEQKEQMGEQKEQMR 411
Query: 264 EQEARL 269
EQE ++
Sbjct: 412 EQEEQM 417
Score = 52.0 bits (123), Expect = 8e-07
Identities = 44/190 (23%), Positives = 87/190 (45%), Gaps = 9/190 (4%)
Query: 90 KPYEEISEELIAERARLQAQREAEELWRQKEAEITKKFRDALANEKARILAEKWKVEMED 149
K E++ ++ R + + RE EE R++E ++ K+ E+ E+ + E E+
Sbjct: 245 KQEEQVQKQEEQMRKQEEQMREQEEQMREQEEQMLKQKEQTEQEEQTGEQEEQMR-EQEE 303
Query: 150 RKAAKVLEERIHEEFKRKEEEERKRGEEQIRLQEEQ--RAKELYW----TLKQAQLHCQA 203
+ + + R EE R++EE+ + EEQ+ Q+EQ KE W + + + Q
Sbjct: 304 QMREQEEQMREQEEQMREQEEQMGKQEEQMWEQKEQMWEQKEQMWKQEEQMGEQEEQMQK 363
Query: 204 SEKEEREWEEQLRRSKAADEERSRRAQRARDEYRHHSLRAIQKGTVAGLSSMFRELGQSH 263
E++ R+ EEQ+R K ++ R + Q + E + + + ++G+
Sbjct: 364 QEEQVRKQEEQMR--KQEEQMRKQEEQMRKQEEQMGEQKEQMGEQKEQMREQEEQMGEQK 421
Query: 264 EQEARLYHHL 273
EQ + H+
Sbjct: 422 EQMRKQEEHM 431
Score = 51.6 bits (122), Expect = 1e-06
Identities = 53/208 (25%), Positives = 102/208 (49%), Gaps = 32/208 (15%)
Query: 22 VQKHILFYKMREEQLRRWKERETWEALAQDEGLRPPKTKRAASDKHIQWLLGADGEVWVW 81
VQK + +EEQ+R+ +E + Q+E +R + + + +
Sbjct: 243 VQKQEEQVQKQEEQMRKQEE----QMREQEEQMREQEEQMLKQKEQTE------------ 286
Query: 82 IMGEGPGDKPYEEISEELIAERARLQAQREAEELWRQKEAEITKKFRDALANEKARILAE 141
E G++ E++ E+ R + + RE EE R++E ++ K+ + + +K ++ +
Sbjct: 287 -QEEQTGEQE-EQMREQEEQMREQEEQMREQEEQMREQEEQMGKQ-EEQMWEQKEQMWEQ 343
Query: 142 K---WKVE-----MEDRKAAKVLEERIHEEFKRKEEEERKRGEEQIRLQEEQRAKELYWT 193
K WK E E++ + + R EE RK+EE+ ++ EEQ+R QEEQ ++
Sbjct: 344 KEQMWKQEEQMGEQEEQMQKQEEQVRKQEEQMRKQEEQMRKQEEQMRKQEEQMGEQKEQM 403
Query: 194 LKQAQLHCQASEKEER--EWEEQLRRSK 219
+Q + Q E+EE+ E +EQ+R+ +
Sbjct: 404 GEQKE---QMREQEEQMGEQKEQMRKQE 428
Score = 50.4 bits (119), Expect = 2e-06
Identities = 42/161 (26%), Positives = 77/161 (47%), Gaps = 4/161 (2%)
Query: 111 EAEELWRQKEAEITKKFRDALANEKARILAEKWKVEMEDRKAAKVLEERIHEEFKRKEEE 170
E EE ++E ++ K+ E+ E+ E E++ + + + EE RK+EE
Sbjct: 203 EQEEQMGEQEEQMQKQEEQMGEQEEQMRKQEEQMGEQEEQVQKQEEQVQKQEEQMRKQEE 262
Query: 171 ERKRGEEQIRLQEEQRAKELYWTLKQAQLHCQASEKEEREWEEQLR--RSKAADEERSRR 228
+ + EEQ+R QEEQ K+ T ++ Q Q E++ RE EEQ+R + ++E R
Sbjct: 263 QMREQEEQMREQEEQMLKQKEQTEQEEQTGEQ--EEQMREQEEQMREQEEQMREQEEQMR 320
Query: 229 AQRARDEYRHHSLRAIQKGTVAGLSSMFRELGQSHEQEARL 269
Q + + + ++ M+++ Q EQE ++
Sbjct: 321 EQEEQMGKQEEQMWEQKEQMWEQKEQMWKQEEQMGEQEEQM 361
Score = 47.4 bits (111), Expect = 2e-05
Identities = 36/154 (23%), Positives = 81/154 (52%), Gaps = 7/154 (4%)
Query: 90 KPYEEISEELIAERARLQAQREAEELWRQKEAEITKKFRDALANEKARILAEKWKVEMED 149
K E++ E+ R + + E EE +++E ++ K+ + + ++ ++ ++ ++ ++
Sbjct: 217 KQEEQMGEQEEQMRKQEEQMGEQEEQVQKQEEQVQKQ-EEQMRKQEEQMREQEEQMREQE 275
Query: 150 RKAAKVLEERIHEEFKRKEEEERKRGEEQIRLQEEQ-RAKELYWTLKQAQLHCQAS---E 205
+ K E+ EE ++EE+ + EEQ+R QEEQ R +E ++ Q+ Q E
Sbjct: 276 EQMLKQKEQTEQEEQTGEQEEQMREQEEQMREQEEQMREQEEQMREQEEQMGKQEEQMWE 335
Query: 206 KEEREWE--EQLRRSKAADEERSRRAQRARDEYR 237
++E+ WE EQ+ + + E+ + Q+ ++ R
Sbjct: 336 QKEQMWEQKEQMWKQEEQMGEQEEQMQKQEEQVR 369
Score = 43.1 bits (100), Expect = 4e-04
Identities = 33/161 (20%), Positives = 74/161 (45%)
Query: 110 REAEELWRQKEAEITKKFRDALANEKARILAEKWKVEMEDRKAAKVLEERIHEEFKRKEE 169
RE E ++E ++ ++ E+ E+ E E++ + + EE +K+E
Sbjct: 188 REQEGQMGEQEGQMGEQEEQMGEQEEQMQKQEEQMGEQEEQMRKQEEQMGEQEEQVQKQE 247
Query: 170 EERKRGEEQIRLQEEQRAKELYWTLKQAQLHCQASEKEEREWEEQLRRSKAADEERSRRA 229
E+ ++ EEQ+R QEEQ ++ +Q + + E+ E+E + + + ++E R
Sbjct: 248 EQVQKQEEQMRKQEEQMREQEEQMREQEEQMLKQKEQTEQEEQTGEQEEQMREQEEQMRE 307
Query: 230 QRARDEYRHHSLRAIQKGTVAGLSSMFRELGQSHEQEARLY 270
Q + + +R ++ M+ + Q EQ+ +++
Sbjct: 308 QEEQMREQEEQMREQEEQMGKQEEQMWEQKEQMWEQKEQMW 348
Score = 41.6 bits (96), Expect = 0.001
Identities = 35/160 (21%), Positives = 70/160 (43%), Gaps = 12/160 (7%)
Query: 110 REAEELWRQKEAEITKKFRDALANEKARILAEKWKVEMEDRKAAKVLEERIHEEFKRKEE 169
RE E R++E ++ ++ E+ E+ + E++ + + R EE ++E
Sbjct: 181 REQEGQVREQEGQMGEQEGQMGEQEEQMGEQEEQMQKQEEQMGEQEEQMRKQEEQMGEQE 240
Query: 170 EERKRGEEQIRLQEEQRAKELYWTLKQAQLHCQASEKEEREWEEQLRRSKAADEERSRRA 229
E+ ++ EEQ++ QEEQ K+ + + E++ RE EEQ+ + K E+ +
Sbjct: 241 EQVQKQEEQVQKQEEQMRKQ--------EEQMREQEEQMREQEEQMLKQKEQTEQEEQTG 292
Query: 230 QRARDEYRHHSLRAIQKGTVAGLSSMFRE----LGQSHEQ 265
++ Q+ + RE +G+ EQ
Sbjct: 293 EQEEQMREQEEQMREQEEQMREQEEQMREQEEQMGKQEEQ 332
Score = 40.8 bits (94), Expect = 0.002
Identities = 32/163 (19%), Positives = 81/163 (49%), Gaps = 20/163 (12%)
Query: 83 MGEGPGDKPYEEISEELIAERARLQAQREA----EELWRQKEAEI------TKKFRDALA 132
MGE G +E E++ + ++Q Q E EE R++E ++ +K + +
Sbjct: 194 MGEQEGQMGEQE--EQMGEQEEQMQKQEEQMGEQEEQMRKQEEQMGEQEEQVQKQEEQVQ 251
Query: 133 NEKARILAEKWKVEMEDRKAAKVLEERIHEEFKRKEEEERKRGEEQIRLQEEQRAKELYW 192
++ ++ ++ ++ ++ + + E+ + ++ + ++EE+ EEQ+R QEEQ
Sbjct: 252 KQEEQMRKQEEQMREQEEQMREQEEQMLKQKEQTEQEEQTGEQEEQMREQEEQ------- 304
Query: 193 TLKQAQLHCQASEKEEREWEEQLRRSKAADEERSRRAQRARDE 235
+++ + + E++ RE EEQ+ + + E+ + +++
Sbjct: 305 -MREQEEQMREQEEQMREQEEQMGKQEEQMWEQKEQMWEQKEQ 346
Score = 36.6 bits (83), Expect = 0.035
Identities = 37/177 (20%), Positives = 77/177 (43%), Gaps = 20/177 (11%)
Query: 110 REAEELWRQKEAEITKKFRDALANEKARILAEKWKVEMEDRKAAKVLEERIHEEFKRKEE 169
RE E R++E ++ ++ + ++ ++ ++ +V E + E ++ E+ + E
Sbjct: 146 REQEGQVREQEGQVREQ-EGQVREQEGQVREQEGQVR-EQEGQVREQEGQMGEQEGQMGE 203
Query: 170 EERKRG----------------EEQIRLQEEQRAKELYWTLKQAQLHCQASEKEEREWEE 213
+E + G EEQ+R QEEQ ++ KQ + Q E++ R+ EE
Sbjct: 204 QEEQMGEQEEQMQKQEEQMGEQEEQMRKQEEQMGEQEEQVQKQEE-QVQKQEEQMRKQEE 262
Query: 214 QLRRSKAADEERSRRAQRARDEYRHHSLRAIQKGTVAGLSSMFREL-GQSHEQEARL 269
Q+R + E+ + + +++ Q+ + RE Q EQE ++
Sbjct: 263 QMREQEEQMREQEEQMLKQKEQTEQEEQTGEQEEQMREQEEQMREQEEQMREQEEQM 319
Score = 35.4 bits (80), Expect = 0.079
Identities = 34/163 (20%), Positives = 79/163 (48%), Gaps = 11/163 (6%)
Query: 110 REAEELWRQKEAEITKKFRDALANEKARILAEKWKVEMEDRKAAKVLEERIHEEFKRKEE 169
RE E R++E ++ ++ + ++ ++ ++ +V E + E ++ E+ + E
Sbjct: 132 REQEGQVREQEGQVREQ-EGQVREQEGQVREQEGQVR-EQEGQVREQEGQVREQEGQVRE 189
Query: 170 EERKRGEE--QIRLQEEQRAKELYWTLKQAQLHCQASEKEE--REWEEQLRRSKAADEER 225
+E + GE+ Q+ QEEQ ++ KQ + Q E+EE R+ EEQ+ + +++
Sbjct: 190 QEGQMGEQEGQMGEQEEQMGEQEEQMQKQEE---QMGEQEEQMRKQEEQMGEQEEQVQKQ 246
Query: 226 SRRAQRARDEYR--HHSLRAIQKGTVAGLSSMFRELGQSHEQE 266
+ Q+ ++ R +R ++ M ++ Q+ ++E
Sbjct: 247 EEQVQKQEEQMRKQEEQMREQEEQMREQEEQMLKQKEQTEQEE 289
Score = 33.5 bits (75), Expect = 0.30
Identities = 36/162 (22%), Positives = 75/162 (46%), Gaps = 32/162 (19%)
Query: 32 REEQLRRWKE--RETWEALAQDEGLRPPKTKRAASDKHIQWLLGADGEVWVWIMGEGPGD 89
+EEQ+R +E RE E + + E + ++ K W + + +W E G+
Sbjct: 301 QEEQMREQEEQMREQEEQMREQEEQMGKQEEQMWEQKEQMW----EQKEQMWKQEEQMGE 356
Query: 90 KPYEEISEELIAERARLQAQREAEELWRQKEAEITKKFRDALANEKARILAEKWKVEMED 149
+ E++ ++ R + + R+ EE R++E ++ K+ + +M +
Sbjct: 357 QE-EQMQKQEEQVRKQEEQMRKQEEQMRKQEEQMRKQ-----------------EEQMGE 398
Query: 150 RKAAKVLEERIHEEFKRKEEEERKRGE--EQIRLQEEQRAKE 189
+K E++ E+ ++ E+E + GE EQ+R QEE ++
Sbjct: 399 QK------EQMGEQKEQMREQEEQMGEQKEQMRKQEEHMGEQ 434
>gi|239735580 TRAF2 and NCK interacting kinase isoform 2 [Homo
sapiens]
Length = 1352
Score = 57.8 bits (138), Expect = 1e-08
Identities = 58/201 (28%), Positives = 94/201 (46%), Gaps = 16/201 (7%)
Query: 93 EEISEELIAERARLQAQREAEELWRQKEAEITKKFRDALANEKARILAEKWKVEMEDRKA 152
+E SE L ++ Q QRE EE RQ AE K+ + E+ R L E+ + E E RK
Sbjct: 362 KERSEALRRQQLE-QQQRENEEHKRQLLAERQKRIEEQ--KEQRRRLEEQQRREKELRKQ 418
Query: 153 AKVLEERIHEEFKRKEEEERKRGEEQ----IRLQEEQRAKELYWTLKQAQLHCQA--SEK 206
+ + R +EE R+EEE R+ EQ +L+EEQR E+ L+Q LH QA E
Sbjct: 419 QEREQRRHYEEQMRREEERRRAEHEQEYIRRQLEEEQRQLEI---LQQQLLHEQALLLEY 475
Query: 207 EEREWEEQLRRSKAADEERSRRAQRARDEYRHHSLRAIQKGTV----AGLSSMFRELGQS 262
+ ++ EEQ + + + + R +++ R ++K + G+S +
Sbjct: 476 KRKQLEEQRQAERLQRQLKQERDYLVSLQHQRQEQRPVEKKPLYHYKEGMSPSEKPAWAK 535
Query: 263 HEQEARLYHHLPDPGLPQPLA 283
+E + P +P +A
Sbjct: 536 EVEERSRLNRQSSPAMPHKVA 556
Score = 42.7 bits (99), Expect = 5e-04
Identities = 33/119 (27%), Positives = 62/119 (52%), Gaps = 18/119 (15%)
Query: 120 EAEITKKF-RDALANEKARILAEKWKVEMEDRKAAKVLEERIHEEFKRKEEEERKRGEEQ 178
E+ + + F R LAN++ + ++E + R+ + + + E KR EE++ E++
Sbjct: 347 ESTLRRDFLRLQLANKERSEALRRQQLEQQQRENEEHKRQLLAERQKRIEEQK----EQR 402
Query: 179 IRLQEEQRAKELYWTLKQAQLHCQASEKEEREWEEQLRRSKAADEERSRRAQRARDEYR 237
RL+E+QR ++ +L Q ++ R +EEQ+RR EE RRA+ ++ R
Sbjct: 403 RRLEEQQR--------REKELRKQQEREQRRHYEEQMRR-----EEERRRAEHEQEYIR 448
>gi|55741807 TRAF2 and NCK interacting kinase isoform 1 [Homo
sapiens]
Length = 1360
Score = 57.8 bits (138), Expect = 1e-08
Identities = 58/201 (28%), Positives = 94/201 (46%), Gaps = 16/201 (7%)
Query: 93 EEISEELIAERARLQAQREAEELWRQKEAEITKKFRDALANEKARILAEKWKVEMEDRKA 152
+E SE L ++ Q QRE EE RQ AE K+ + E+ R L E+ + E E RK
Sbjct: 362 KERSEALRRQQLE-QQQRENEEHKRQLLAERQKRIEEQ--KEQRRRLEEQQRREKELRKQ 418
Query: 153 AKVLEERIHEEFKRKEEEERKRGEEQ----IRLQEEQRAKELYWTLKQAQLHCQA--SEK 206
+ + R +EE R+EEE R+ EQ +L+EEQR E+ L+Q LH QA E
Sbjct: 419 QEREQRRHYEEQMRREEERRRAEHEQEYIRRQLEEEQRQLEI---LQQQLLHEQALLLEY 475
Query: 207 EEREWEEQLRRSKAADEERSRRAQRARDEYRHHSLRAIQKGTV----AGLSSMFRELGQS 262
+ ++ EEQ + + + + R +++ R ++K + G+S +
Sbjct: 476 KRKQLEEQRQAERLQRQLKQERDYLVSLQHQRQEQRPVEKKPLYHYKEGMSPSEKPAWAK 535
Query: 263 HEQEARLYHHLPDPGLPQPLA 283
+E + P +P +A
Sbjct: 536 EVEERSRLNRQSSPAMPHKVA 556
Score = 42.7 bits (99), Expect = 5e-04
Identities = 33/119 (27%), Positives = 62/119 (52%), Gaps = 18/119 (15%)
Query: 120 EAEITKKF-RDALANEKARILAEKWKVEMEDRKAAKVLEERIHEEFKRKEEEERKRGEEQ 178
E+ + + F R LAN++ + ++E + R+ + + + E KR EE++ E++
Sbjct: 347 ESTLRRDFLRLQLANKERSEALRRQQLEQQQRENEEHKRQLLAERQKRIEEQK----EQR 402
Query: 179 IRLQEEQRAKELYWTLKQAQLHCQASEKEEREWEEQLRRSKAADEERSRRAQRARDEYR 237
RL+E+QR ++ +L Q ++ R +EEQ+RR EE RRA+ ++ R
Sbjct: 403 RRLEEQQR--------REKELRKQQEREQRRHYEEQMRR-----EEERRRAEHEQEYIR 448
>gi|225579095 S-phase cyclin A-associated protein in the ER isoform
b [Homo sapiens]
Length = 1154
Score = 56.6 bits (135), Expect = 3e-08
Identities = 65/252 (25%), Positives = 108/252 (42%), Gaps = 57/252 (22%)
Query: 29 YKMREEQLRRWKERETWEALAQDEGLRPPKTKRAASDKHIQWLLGADGEVWVWIMGEGPG 88
Y+ RE W++ +W + ++E RPP G G
Sbjct: 251 YEARES----WRQNTSWGDIVEEEPARPP----------------------------GHG 278
Query: 89 DKPYEEIS----EELIAERARL--QAQREAEELWRQKEAEITKKFRDALANEKARILAEK 142
+E++S + IAE + + Q +A++L + E T K + L EK K
Sbjct: 279 IHMHEKLSSPSRKRTIAESKKKHEEKQMKAQQLREKLREEKTLKLQKLLEREKD---VRK 335
Query: 143 WKVEMEDRKAAKVLEERIHEEFKRKEEEE---RKRGEEQIRLQEEQRAKELYWTLKQAQL 199
WK E+ D++ + E+ +H EFKR+ + + +K EE+ ++ E L K+ +
Sbjct: 336 WKEELLDQRRRMMEEKLLHAEFKREVQLQAIVKKAQEEEAKVNEIAFINTLEAQNKRHDV 395
Query: 200 HCQASEKEEREWEEQLRRSKAADEERSRRAQ--RARDEYRHHSLRAIQKGTVAGLSSMFR 257
+ E E+R E Q EER RR + +ARDE RA++ A + +
Sbjct: 396 LSKLKEYEQRLNELQ--------EERQRRQEEKQARDEAVQERKRALEAERQARVEEL-- 445
Query: 258 ELGQSHEQEARL 269
L + EQEAR+
Sbjct: 446 -LMKRKEQEARI 456
Score = 35.0 bits (79), Expect = 0.10
Identities = 41/172 (23%), Positives = 76/172 (44%), Gaps = 15/172 (8%)
Query: 94 EISEELIAERARLQAQREAEELWRQKEAEITKKFRDALAN-----EKARILAEKWKVEME 148
E+ + I ++A+ + + + E+ E K D L+ ++ L E+ + E
Sbjct: 360 EVQLQAIVKKAQ-EEEAKVNEIAFINTLEAQNKRHDVLSKLKEYEQRLNELQEERQRRQE 418
Query: 149 DRKAAKVLEERIHEEFKRKEEEERKRGEEQIRLQEEQRAKELYWTLKQAQLHCQASEKEE 208
+++A +E + E + E E + R EE + ++EQ A+ ++ + A+ +
Sbjct: 419 EKQAR---DEAVQERKRALEAERQARVEELLMKRKEQEARIEQQRQEKEKAREDAARERA 475
Query: 209 REWEEQLRRSKAAD----EERSRRAQRARDE--YRHHSLRAIQKGTVAGLSS 254
R+ EE+L AA EE ++ Q DE RH +K A LSS
Sbjct: 476 RDREERLAALTAAQQEAMEELQKKIQLKHDESIRRHMEQIEQRKEKAAELSS 527
Score = 30.4 bits (67), Expect = 2.5
Identities = 38/166 (22%), Positives = 70/166 (42%), Gaps = 51/166 (30%)
Query: 89 DKPYEEISEELIAERARLQAQREAEE-----LWRQKEAE--------------ITKKFRD 129
+K EE IAE +L + EAEE + +++ ++ + D
Sbjct: 187 EKANEEAIASAIAEEEQLTREIEAEENNDINIETDNDSDFSASMGSGSVSFCGMSMDWND 246
Query: 130 ALANEKARILAEKWK--------------------VEMEDRKAAKVLEERIHEEFKRKEE 169
LA+ +AR E W+ + M ++ ++ + I E K+ EE
Sbjct: 247 VLADYEAR---ESWRQNTSWGDIVEEEPARPPGHGIHMHEKLSSPSRKRTIAESKKKHEE 303
Query: 170 EERKRGEEQIRLQEEQRAKELYWTLKQAQLHCQASEKEEREWEEQL 215
++ K + + +L+EE+ TLK +L EK+ R+W+E+L
Sbjct: 304 KQMKAQQLREKLREEK-------TLKLQKL--LEREKDVRKWKEEL 340
>gi|225579092 S-phase cyclin A-associated protein in the ER isoform
a [Homo sapiens]
Length = 1400
Score = 56.6 bits (135), Expect = 3e-08
Identities = 65/252 (25%), Positives = 108/252 (42%), Gaps = 57/252 (22%)
Query: 29 YKMREEQLRRWKERETWEALAQDEGLRPPKTKRAASDKHIQWLLGADGEVWVWIMGEGPG 88
Y+ RE W++ +W + ++E RPP G G
Sbjct: 497 YEARES----WRQNTSWGDIVEEEPARPP----------------------------GHG 524
Query: 89 DKPYEEIS----EELIAERARL--QAQREAEELWRQKEAEITKKFRDALANEKARILAEK 142
+E++S + IAE + + Q +A++L + E T K + L EK K
Sbjct: 525 IHMHEKLSSPSRKRTIAESKKKHEEKQMKAQQLREKLREEKTLKLQKLLEREKD---VRK 581
Query: 143 WKVEMEDRKAAKVLEERIHEEFKRKEEEE---RKRGEEQIRLQEEQRAKELYWTLKQAQL 199
WK E+ D++ + E+ +H EFKR+ + + +K EE+ ++ E L K+ +
Sbjct: 582 WKEELLDQRRRMMEEKLLHAEFKREVQLQAIVKKAQEEEAKVNEIAFINTLEAQNKRHDV 641
Query: 200 HCQASEKEEREWEEQLRRSKAADEERSRRAQ--RARDEYRHHSLRAIQKGTVAGLSSMFR 257
+ E E+R E Q EER RR + +ARDE RA++ A + +
Sbjct: 642 LSKLKEYEQRLNELQ--------EERQRRQEEKQARDEAVQERKRALEAERQARVEEL-- 691
Query: 258 ELGQSHEQEARL 269
L + EQEAR+
Sbjct: 692 -LMKRKEQEARI 702
Score = 35.0 bits (79), Expect = 0.10
Identities = 41/172 (23%), Positives = 76/172 (44%), Gaps = 15/172 (8%)
Query: 94 EISEELIAERARLQAQREAEELWRQKEAEITKKFRDALAN-----EKARILAEKWKVEME 148
E+ + I ++A+ + + + E+ E K D L+ ++ L E+ + E
Sbjct: 606 EVQLQAIVKKAQ-EEEAKVNEIAFINTLEAQNKRHDVLSKLKEYEQRLNELQEERQRRQE 664
Query: 149 DRKAAKVLEERIHEEFKRKEEEERKRGEEQIRLQEEQRAKELYWTLKQAQLHCQASEKEE 208
+++A +E + E + E E + R EE + ++EQ A+ ++ + A+ +
Sbjct: 665 EKQAR---DEAVQERKRALEAERQARVEELLMKRKEQEARIEQQRQEKEKAREDAARERA 721
Query: 209 REWEEQLRRSKAAD----EERSRRAQRARDE--YRHHSLRAIQKGTVAGLSS 254
R+ EE+L AA EE ++ Q DE RH +K A LSS
Sbjct: 722 RDREERLAALTAAQQEAMEELQKKIQLKHDESIRRHMEQIEQRKEKAAELSS 773
Score = 30.4 bits (67), Expect = 2.5
Identities = 38/166 (22%), Positives = 70/166 (42%), Gaps = 51/166 (30%)
Query: 89 DKPYEEISEELIAERARLQAQREAEE-----LWRQKEAE--------------ITKKFRD 129
+K EE IAE +L + EAEE + +++ ++ + D
Sbjct: 433 EKANEEAIASAIAEEEQLTREIEAEENNDINIETDNDSDFSASMGSGSVSFCGMSMDWND 492
Query: 130 ALANEKARILAEKWK--------------------VEMEDRKAAKVLEERIHEEFKRKEE 169
LA+ +AR E W+ + M ++ ++ + I E K+ EE
Sbjct: 493 VLADYEAR---ESWRQNTSWGDIVEEEPARPPGHGIHMHEKLSSPSRKRTIAESKKKHEE 549
Query: 170 EERKRGEEQIRLQEEQRAKELYWTLKQAQLHCQASEKEEREWEEQL 215
++ K + + +L+EE+ TLK +L EK+ R+W+E+L
Sbjct: 550 KQMKAQQLREKLREEK-------TLKLQKL--LEREKDVRKWKEEL 586
>gi|239735588 TRAF2 and NCK interacting kinase isoform 6 [Homo
sapiens]
Length = 1297
Score = 56.2 bits (134), Expect = 4e-08
Identities = 54/156 (34%), Positives = 77/156 (49%), Gaps = 17/156 (10%)
Query: 93 EEISEELIAERARLQAQREAEELWRQKEAEITKKFRDALANEKARILAEKWKVEMEDRKA 152
+E SE L ++ Q QRE EE RQ AE K+ + E+ R L E+ + E E RK
Sbjct: 362 KERSEALRRQQLE-QQQRENEEHKRQLLAERQKRIEEQ--KEQRRRLEEQQRREKELRKQ 418
Query: 153 AKVLEERIHEEFKRKEEEERKRGEEQ----IRLQEEQRAKELYWTLKQAQLHCQA----- 203
+ + R +EE R+EEE R+ EQ +L+EEQR E+ L+Q LH QA
Sbjct: 419 QEREQRRHYEEQMRREEERRRAEHEQEYIRRQLEEEQRQLEI---LQQQLLHEQALLLEY 475
Query: 204 --SEKEEREWEEQLRRSKAADEERSRRAQRARDEYR 237
+ EE+ E+L+R + + Q R E R
Sbjct: 476 KRKQLEEQRQAERLQRQLKQERDYLVSLQHQRQEQR 511
Score = 42.7 bits (99), Expect = 5e-04
Identities = 33/119 (27%), Positives = 62/119 (52%), Gaps = 18/119 (15%)
Query: 120 EAEITKKF-RDALANEKARILAEKWKVEMEDRKAAKVLEERIHEEFKRKEEEERKRGEEQ 178
E+ + + F R LAN++ + ++E + R+ + + + E KR EE++ E++
Sbjct: 347 ESTLRRDFLRLQLANKERSEALRRQQLEQQQRENEEHKRQLLAERQKRIEEQK----EQR 402
Query: 179 IRLQEEQRAKELYWTLKQAQLHCQASEKEEREWEEQLRRSKAADEERSRRAQRARDEYR 237
RL+E+QR ++ +L Q ++ R +EEQ+RR EE RRA+ ++ R
Sbjct: 403 RRLEEQQR--------REKELRKQQEREQRRHYEEQMRR-----EEERRRAEHEQEYIR 448
>gi|239735586 TRAF2 and NCK interacting kinase isoform 5 [Homo
sapiens]
Length = 1305
Score = 56.2 bits (134), Expect = 4e-08
Identities = 54/156 (34%), Positives = 77/156 (49%), Gaps = 17/156 (10%)
Query: 93 EEISEELIAERARLQAQREAEELWRQKEAEITKKFRDALANEKARILAEKWKVEMEDRKA 152
+E SE L ++ Q QRE EE RQ AE K+ + E+ R L E+ + E E RK
Sbjct: 362 KERSEALRRQQLE-QQQRENEEHKRQLLAERQKRIEEQ--KEQRRRLEEQQRREKELRKQ 418
Query: 153 AKVLEERIHEEFKRKEEEERKRGEEQ----IRLQEEQRAKELYWTLKQAQLHCQA----- 203
+ + R +EE R+EEE R+ EQ +L+EEQR E+ L+Q LH QA
Sbjct: 419 QEREQRRHYEEQMRREEERRRAEHEQEYIRRQLEEEQRQLEI---LQQQLLHEQALLLEY 475
Query: 204 --SEKEEREWEEQLRRSKAADEERSRRAQRARDEYR 237
+ EE+ E+L+R + + Q R E R
Sbjct: 476 KRKQLEEQRQAERLQRQLKQERDYLVSLQHQRQEQR 511
Score = 42.7 bits (99), Expect = 5e-04
Identities = 33/119 (27%), Positives = 62/119 (52%), Gaps = 18/119 (15%)
Query: 120 EAEITKKF-RDALANEKARILAEKWKVEMEDRKAAKVLEERIHEEFKRKEEEERKRGEEQ 178
E+ + + F R LAN++ + ++E + R+ + + + E KR EE++ E++
Sbjct: 347 ESTLRRDFLRLQLANKERSEALRRQQLEQQQRENEEHKRQLLAERQKRIEEQK----EQR 402
Query: 179 IRLQEEQRAKELYWTLKQAQLHCQASEKEEREWEEQLRRSKAADEERSRRAQRARDEYR 237
RL+E+QR ++ +L Q ++ R +EEQ+RR EE RRA+ ++ R
Sbjct: 403 RRLEEQQR--------REKELRKQQEREQRRHYEEQMRR-----EEERRRAEHEQEYIR 448
>gi|41322923 plectin 1 isoform 11 [Homo sapiens]
Length = 4547
Score = 55.5 bits (132), Expect = 7e-08
Identities = 63/237 (26%), Positives = 111/237 (46%), Gaps = 31/237 (13%)
Query: 17 AELSDVQKHILFYKMREEQLRRWKERETWEA-----LAQDEGLRPPKTKRAA-------S 64
A L +V++ K + E+ RR +ER E+ LAQ+ + + + A
Sbjct: 2006 AALEEVER----LKAKVEEARRLRERAEQESARQLQLAQEAAQKRLQAEEKAHAFAVQQK 2061
Query: 65 DKHIQWLLGADGEVWVWIMGEGPGDKPYEEISEELIAERARLQAQREAEELWRQ-KEAEI 123
++ +Q L + V + GE + E +EE AR+QA+REA + RQ +EAE
Sbjct: 2062 EQELQQTLQQEQSVLDQLRGEAEAARRAAEEAEE-----ARVQAEREAAQSRRQVEEAER 2116
Query: 124 TKKFRD--ALANEKARILAEKWKVEMEDRKAAKVLEERI---HEEFKRKEEEERKRGEEQ 178
K+ + A A +A+ AEK + E E A + E+ ++ E E+ K+ EQ
Sbjct: 2117 LKQSAEEQAQARAQAQAAAEKLRKEAEQEAARRAQAEQAALRQKQAADAEMEKHKKFAEQ 2176
Query: 179 IRLQEEQRAKELYWTLKQAQLHCQASEKEEREWEEQLRRSKAADEERSRRAQRARDE 235
Q+ Q +E L +L + ++ ++ +E+L+R KA E +R+ + +E
Sbjct: 2177 TLRQKAQVEQE----LTTLRLQLEETDHQKNLLDEELQRLKAEATEAARQRSQVEEE 2229
Score = 46.6 bits (109), Expect = 3e-05
Identities = 67/271 (24%), Positives = 111/271 (40%), Gaps = 36/271 (13%)
Query: 28 FYKMREEQLRRWKERETWEALAQDEGLRPPKTKRAASDKHIQWLLGADGEVWVWIMGEGP 87
+ K E LRR +E E + E AA +K Q A+ E
Sbjct: 1333 YIKFISETLRRMEEEERLAEQQRAEERERLAEVEAALEKQRQL---AEAHAQAKAQAERE 1389
Query: 88 GDKPYEEISEELI--------AERARLQAQREAEELWRQKEAEITKKFRDALANEKARIL 139
+ + + EE++ A++ + Q E ++L + EAEI K R A A E++R+
Sbjct: 1390 AKELQQRMQEEVVRREEAAVDAQQQKRSIQEELQQLRQSSEAEIQAKARQAEAAERSRLR 1449
Query: 140 AE------KWKVEMEDRKAAKVLEERIHEEFKRKEEEERKR--GEEQIRLQ-----EEQR 186
E + ++E +R+ E + +E E +KR EE RL+ E QR
Sbjct: 1450 IEEEIRVVRLQLEATERQRGGAEGELQALRARAEEAEAQKRQAQEEAERLRRQVQDESQR 1509
Query: 187 AKELYWTL-----------KQAQLHCQASEKEEREWEEQLRRSKAADEERSRRAQRARDE 235
++ L ++ Q QA E+ + EE RR + A+ ER+R+ Q A E
Sbjct: 1510 KRQAEVELASRVKAEAEAAREKQRALQALEELRLQAEEAERRLRQAEVERARQVQVAL-E 1568
Query: 236 YRHHSLRAIQKGTVAGLSSMFRELGQSHEQE 266
S A + A + +L +S ++E
Sbjct: 1569 TAQRSAEAELQSKRASFAEKTAQLERSLQEE 1599
Score = 43.5 bits (101), Expect = 3e-04
Identities = 44/151 (29%), Positives = 73/151 (48%), Gaps = 8/151 (5%)
Query: 102 ERARLQAQREAEELWRQKEAEITKKFRDALANEKARI---LAEKWKVEMEDRKAAKVLEE 158
ERAR Q Q E R EAE+ K R + A + A++ L E+ + R+ A+ +
Sbjct: 1558 ERAR-QVQVALETAQRSAEAELQSK-RASFAEKTAQLERSLQEEHVAVAQLREEAERRAQ 1615
Query: 159 RIHEEFKRKEEEERKRGEEQIRLQEEQRAKELYWTLKQAQLHCQA-SEKEEREWEEQLRR 217
+ E + +EE ER+ Q++ E R + + Q + QA +EK++ E E + RR
Sbjct: 1616 QQAEAERAREEAERELERWQLKANEALRLRLQAEEVAQQKSLAQAEAEKQKEEAEREARR 1675
Query: 218 SKAADEERSRRAQRARDEYRHHSLRAIQKGT 248
A+E+ R+ + A E R + +GT
Sbjct: 1676 RGKAEEQAVRQRELAEQELEKQ--RQLAEGT 1704
Score = 43.1 bits (100), Expect = 4e-04
Identities = 56/213 (26%), Positives = 92/213 (43%), Gaps = 41/213 (19%)
Query: 93 EEISEELIAERARLQAQREAEELWRQKEAEITKKFRDALANEKARIL------------- 139
E ++ + E A +AQ++AE ++EAE + ANE R+
Sbjct: 1599 EHVAVAQLREEAERRAQQQAEAERAREEAERELERWQLKANEALRLRLQAEEVAQQKSLA 1658
Query: 140 ---AEKWK--VEMEDRKAAKVLEERIHEEFKRKEEEERKR-------------GEEQIRL 181
AEK K E E R+ K E+ + + ++E E++R +E IRL
Sbjct: 1659 QAEAEKQKEEAEREARRRGKAEEQAVRQRELAEQELEKQRQLAEGTAQQRLAAEQELIRL 1718
Query: 182 -----QEEQRAKELYWTLKQAQLHCQASEKEEREWEEQLRRSKAADEERSRRAQRARDEY 236
Q EQ+ + L L + Q A+ ++ +E E +L + +A E RA +E
Sbjct: 1719 RAETEQGEQQRQLLEEELARLQREAAAATQKRQELEAELAKVRAEMEVLLASKARAEEES 1778
Query: 237 RHHSLRAIQKGTVAGLSSMFRELGQSHEQEARL 269
R S ++ Q+ + + FREL E+ ARL
Sbjct: 1779 RSTSEKSKQR--LEAEAGRFRELA---EEAARL 1806
Score = 41.6 bits (96), Expect = 0.001
Identities = 54/206 (26%), Positives = 96/206 (46%), Gaps = 16/206 (7%)
Query: 40 KERETWEALAQDEGLRPPKTKRAASDKHIQWLLGADGEVWVWIMGEGPGDKPYEEISEEL 99
+E + LA+++ R +RA +++ + L A GE K E +E L
Sbjct: 1811 EEAKRQRQLAEEDAAR----QRAEAERVLAEKLAAIGEATRLKTEAEIALKEKEAENERL 1866
Query: 100 --IAERARLQAQREAEELWRQKEAEITKKFRDALANEKARILAEKWKVEMEDRKAAKVLE 157
+AE Q +R EE Q +A+I ++ + + +K VE R+ +V E
Sbjct: 1867 RRLAEDEAFQ-RRRLEEQAAQHKADIEERLAQLRKASDSELERQKGLVEDTLRQRRQVEE 1925
Query: 158 E--RIHEEFKR----KEEEERKRGEEQIRLQEEQRAKEL--YWTLKQAQLHCQASEKEER 209
E + F++ K E E + G + ++ R+KE +Q QL + E+ R
Sbjct: 1926 EILALKASFEKAAAGKAELELELGRIRSNAEDTLRSKEQAELEAARQRQLAAE-EERRRR 1984
Query: 210 EWEEQLRRSKAADEERSRRAQRARDE 235
E EE++++S AA+EE +R+ + A +E
Sbjct: 1985 EAEERVQKSLAAEEEAARQRKAALEE 2010
Score = 40.8 bits (94), Expect = 0.002
Identities = 42/162 (25%), Positives = 76/162 (46%), Gaps = 8/162 (4%)
Query: 117 RQKEAEIT--KKFRDALANEKARILAEKWKVEMEDRKAAKVLEERIHEEFKRKE---EEE 171
RQ E EI K + A KA + E ++ + E+ E ++++ EEE
Sbjct: 1921 RQVEEEILALKASFEKAAAGKAELELELGRIRSNAEDTLRSKEQAELEAARQRQLAAEEE 1980
Query: 172 RKRGEEQIRLQEEQRAKELYWTLKQAQLHCQASEKEEREWEEQLRRSKAADEERSRRAQR 231
R+R E + R+Q+ A+E +Q + + E+ + + EE R + A++E +R+ Q
Sbjct: 1981 RRRREAEERVQKSLAAEE--EAARQRKAALEEVERLKAKVEEARRLRERAEQESARQLQL 2038
Query: 232 ARDEYRHHSLRAIQKGTVAGLSSMFRELGQSHEQEARLYHHL 273
A+ E L+A +K + +EL Q+ +QE + L
Sbjct: 2039 AQ-EAAQKRLQAEEKAHAFAVQQKEQELQQTLQQEQSVLDQL 2079
Score = 39.7 bits (91), Expect = 0.004
Identities = 32/145 (22%), Positives = 70/145 (48%), Gaps = 5/145 (3%)
Query: 93 EEISEELIAERARLQAQREAEELWRQKEA-EITKKFRDALANEKARILAEKWKVEMEDRK 151
E E+L E LQ + E + +Q++ + T+ + + +EK +L + +E E K
Sbjct: 2456 EREKEKLQQEAKLLQLKSEEMQTVQQEQLLQETQALQQSFLSEKDSLLQRERFIEQEKAK 2515
Query: 152 AAKVLEERIHEEFKRKEEEERKRGEEQIRLQEEQRAKELYWTLKQAQLHCQASEKEEREW 211
++ ++ + + + +EE++R ++Q QE QR ++ Q + + ++E
Sbjct: 2516 LEQLFQDEVAKAQQLREEQQR---QQQQMEQERQRLVASMEEARRRQHEAEEGVRRKQEE 2572
Query: 212 EEQLRRSKAADEE-RSRRAQRARDE 235
+QL + + EE + QR R++
Sbjct: 2573 LQQLEQQRRQQEELLAEENQRLREQ 2597
Score = 37.7 bits (86), Expect = 0.016
Identities = 46/172 (26%), Positives = 77/172 (44%), Gaps = 24/172 (13%)
Query: 97 EELIAERARLQAQ--------REAEELWRQKEAEITKKFRDALANEKARILAEKWK---- 144
E+L+ E LQ + E Q++A++ + F+D +A KA+ L E+ +
Sbjct: 2482 EQLLQETQALQQSFLSEKDSLLQRERFIEQEKAKLEQLFQDEVA--KAQQLREEQQRQQQ 2539
Query: 145 -VEMEDRKAAKVLEE---RIHE--EFKRKEEEERKRGEEQIRLQEEQRAKELYWTLKQAQ 198
+E E ++ +EE R HE E R+++EE ++ E+Q R QEE A+E +Q Q
Sbjct: 2540 QMEQERQRLVASMEEARRRQHEAEEGVRRKQEELQQLEQQRRQQEELLAEENQRLREQLQ 2599
Query: 199 L----HCQASEKEEREWEEQLRRSKAADEERSRRAQRARDEYRHHSLRAIQK 246
L H A E Q+ +K R A + HS +++
Sbjct: 2600 LLEEQHRAALAHSEEVTASQVAATKTLPNGRDALDGPAAEAEPEHSFDGLRR 2651
Score = 35.0 bits (79), Expect = 0.10
Identities = 35/172 (20%), Positives = 79/172 (45%), Gaps = 4/172 (2%)
Query: 97 EELIAERARLQAQREAEELWRQKEAEITKKFRDALANEKARILAEKWKVEMEDRKAAKVL 156
EEL +AR++A+ A L ++ + T++F A + ++ E ++ + ++AA++
Sbjct: 2238 EELSKLKARIEAENRALIL---RDKDNTQRFLQEEAEKMKQVAEEAARLSVAAQEAARLR 2294
Query: 157 EERIHEEFKRKEEEERKRGEEQIRLQEEQRAKELYWTLKQAQLHCQASEKEEREWEEQLR 216
+ + +++ E+ E+ +QE R K L+Q + Q + +E +EQ+
Sbjct: 2295 QLAEEDLAQQRALAEKMLKEKMQAVQEATRLKAEAELLQQQKELAQEQARRLQEDKEQMA 2354
Query: 217 RSKAADEERSRRAQRARDEYRHHSLRAIQKGTVAGLSSMFRELGQSHEQEAR 268
+ A + + +R A + R + A + ++ M R ++ E R
Sbjct: 2355 QQLAEETQGFQRTLEA-ERQRQLEMSAEAERLKLRVAEMSRAQARAEEDAQR 2405
Score = 34.7 bits (78), Expect = 0.13
Identities = 47/191 (24%), Positives = 84/191 (43%), Gaps = 22/191 (11%)
Query: 101 AERARLQAQREAEELWRQKEAEITKKFRDALANEKARILAE-----KWKVEMEDRKAAKV 155
AE+ R +A++EA + ++A + +K EK + AE K +VE E
Sbjct: 2135 AEKLRKEAEQEAARRAQAEQAALRQKQAADAEMEKHKKFAEQTLRQKAQVEQELTTLRLQ 2194
Query: 156 LEERIH------EEFKRKEEE------ERKRGEEQ---IRLQEEQRAK-ELYWTLKQAQL 199
LEE H EE +R + E +R + EE+ +R+Q E+ +K + + L
Sbjct: 2195 LEETDHQKNLLDEELQRLKAEATEAARQRSQVEEELFSVRVQMEELSKLKARIEAENRAL 2254
Query: 200 HCQASEKEEREWEEQLRRSKAADEERSRRAQRARDEYRHHSLRAIQKGTVAGLS-SMFRE 258
+ + +R +E+ + K EE +R + A++ R L L+ M +E
Sbjct: 2255 ILRDKDNTQRFLQEEAEKMKQVAEEAARLSVAAQEAARLRQLAEEDLAQQRALAEKMLKE 2314
Query: 259 LGQSHEQEARL 269
Q+ ++ RL
Sbjct: 2315 KMQAVQEATRL 2325
>gi|41322914 plectin 1 isoform 10 [Homo sapiens]
Length = 4551
Score = 55.5 bits (132), Expect = 7e-08
Identities = 63/237 (26%), Positives = 111/237 (46%), Gaps = 31/237 (13%)
Query: 17 AELSDVQKHILFYKMREEQLRRWKERETWEA-----LAQDEGLRPPKTKRAA-------S 64
A L +V++ K + E+ RR +ER E+ LAQ+ + + + A
Sbjct: 2010 AALEEVER----LKAKVEEARRLRERAEQESARQLQLAQEAAQKRLQAEEKAHAFAVQQK 2065
Query: 65 DKHIQWLLGADGEVWVWIMGEGPGDKPYEEISEELIAERARLQAQREAEELWRQ-KEAEI 123
++ +Q L + V + GE + E +EE AR+QA+REA + RQ +EAE
Sbjct: 2066 EQELQQTLQQEQSVLDQLRGEAEAARRAAEEAEE-----ARVQAEREAAQSRRQVEEAER 2120
Query: 124 TKKFRD--ALANEKARILAEKWKVEMEDRKAAKVLEERI---HEEFKRKEEEERKRGEEQ 178
K+ + A A +A+ AEK + E E A + E+ ++ E E+ K+ EQ
Sbjct: 2121 LKQSAEEQAQARAQAQAAAEKLRKEAEQEAARRAQAEQAALRQKQAADAEMEKHKKFAEQ 2180
Query: 179 IRLQEEQRAKELYWTLKQAQLHCQASEKEEREWEEQLRRSKAADEERSRRAQRARDE 235
Q+ Q +E L +L + ++ ++ +E+L+R KA E +R+ + +E
Sbjct: 2181 TLRQKAQVEQE----LTTLRLQLEETDHQKNLLDEELQRLKAEATEAARQRSQVEEE 2233
Score = 46.6 bits (109), Expect = 3e-05
Identities = 67/271 (24%), Positives = 111/271 (40%), Gaps = 36/271 (13%)
Query: 28 FYKMREEQLRRWKERETWEALAQDEGLRPPKTKRAASDKHIQWLLGADGEVWVWIMGEGP 87
+ K E LRR +E E + E AA +K Q A+ E
Sbjct: 1337 YIKFISETLRRMEEEERLAEQQRAEERERLAEVEAALEKQRQL---AEAHAQAKAQAERE 1393
Query: 88 GDKPYEEISEELI--------AERARLQAQREAEELWRQKEAEITKKFRDALANEKARIL 139
+ + + EE++ A++ + Q E ++L + EAEI K R A A E++R+
Sbjct: 1394 AKELQQRMQEEVVRREEAAVDAQQQKRSIQEELQQLRQSSEAEIQAKARQAEAAERSRLR 1453
Query: 140 AE------KWKVEMEDRKAAKVLEERIHEEFKRKEEEERKR--GEEQIRLQ-----EEQR 186
E + ++E +R+ E + +E E +KR EE RL+ E QR
Sbjct: 1454 IEEEIRVVRLQLEATERQRGGAEGELQALRARAEEAEAQKRQAQEEAERLRRQVQDESQR 1513
Query: 187 AKELYWTL-----------KQAQLHCQASEKEEREWEEQLRRSKAADEERSRRAQRARDE 235
++ L ++ Q QA E+ + EE RR + A+ ER+R+ Q A E
Sbjct: 1514 KRQAEVELASRVKAEAEAAREKQRALQALEELRLQAEEAERRLRQAEVERARQVQVAL-E 1572
Query: 236 YRHHSLRAIQKGTVAGLSSMFRELGQSHEQE 266
S A + A + +L +S ++E
Sbjct: 1573 TAQRSAEAELQSKRASFAEKTAQLERSLQEE 1603
Score = 43.5 bits (101), Expect = 3e-04
Identities = 44/151 (29%), Positives = 73/151 (48%), Gaps = 8/151 (5%)
Query: 102 ERARLQAQREAEELWRQKEAEITKKFRDALANEKARI---LAEKWKVEMEDRKAAKVLEE 158
ERAR Q Q E R EAE+ K R + A + A++ L E+ + R+ A+ +
Sbjct: 1562 ERAR-QVQVALETAQRSAEAELQSK-RASFAEKTAQLERSLQEEHVAVAQLREEAERRAQ 1619
Query: 159 RIHEEFKRKEEEERKRGEEQIRLQEEQRAKELYWTLKQAQLHCQA-SEKEEREWEEQLRR 217
+ E + +EE ER+ Q++ E R + + Q + QA +EK++ E E + RR
Sbjct: 1620 QQAEAERAREEAERELERWQLKANEALRLRLQAEEVAQQKSLAQAEAEKQKEEAEREARR 1679
Query: 218 SKAADEERSRRAQRARDEYRHHSLRAIQKGT 248
A+E+ R+ + A E R + +GT
Sbjct: 1680 RGKAEEQAVRQRELAEQELEKQ--RQLAEGT 1708
Score = 43.1 bits (100), Expect = 4e-04
Identities = 56/213 (26%), Positives = 92/213 (43%), Gaps = 41/213 (19%)
Query: 93 EEISEELIAERARLQAQREAEELWRQKEAEITKKFRDALANEKARIL------------- 139
E ++ + E A +AQ++AE ++EAE + ANE R+
Sbjct: 1603 EHVAVAQLREEAERRAQQQAEAERAREEAERELERWQLKANEALRLRLQAEEVAQQKSLA 1662
Query: 140 ---AEKWK--VEMEDRKAAKVLEERIHEEFKRKEEEERKR-------------GEEQIRL 181
AEK K E E R+ K E+ + + ++E E++R +E IRL
Sbjct: 1663 QAEAEKQKEEAEREARRRGKAEEQAVRQRELAEQELEKQRQLAEGTAQQRLAAEQELIRL 1722
Query: 182 -----QEEQRAKELYWTLKQAQLHCQASEKEEREWEEQLRRSKAADEERSRRAQRARDEY 236
Q EQ+ + L L + Q A+ ++ +E E +L + +A E RA +E
Sbjct: 1723 RAETEQGEQQRQLLEEELARLQREAAAATQKRQELEAELAKVRAEMEVLLASKARAEEES 1782
Query: 237 RHHSLRAIQKGTVAGLSSMFRELGQSHEQEARL 269
R S ++ Q+ + + FREL E+ ARL
Sbjct: 1783 RSTSEKSKQR--LEAEAGRFRELA---EEAARL 1810
Score = 41.6 bits (96), Expect = 0.001
Identities = 54/206 (26%), Positives = 96/206 (46%), Gaps = 16/206 (7%)
Query: 40 KERETWEALAQDEGLRPPKTKRAASDKHIQWLLGADGEVWVWIMGEGPGDKPYEEISEEL 99
+E + LA+++ R +RA +++ + L A GE K E +E L
Sbjct: 1815 EEAKRQRQLAEEDAAR----QRAEAERVLAEKLAAIGEATRLKTEAEIALKEKEAENERL 1870
Query: 100 --IAERARLQAQREAEELWRQKEAEITKKFRDALANEKARILAEKWKVEMEDRKAAKVLE 157
+AE Q +R EE Q +A+I ++ + + +K VE R+ +V E
Sbjct: 1871 RRLAEDEAFQ-RRRLEEQAAQHKADIEERLAQLRKASDSELERQKGLVEDTLRQRRQVEE 1929
Query: 158 E--RIHEEFKR----KEEEERKRGEEQIRLQEEQRAKEL--YWTLKQAQLHCQASEKEER 209
E + F++ K E E + G + ++ R+KE +Q QL + E+ R
Sbjct: 1930 EILALKASFEKAAAGKAELELELGRIRSNAEDTLRSKEQAELEAARQRQLAAE-EERRRR 1988
Query: 210 EWEEQLRRSKAADEERSRRAQRARDE 235
E EE++++S AA+EE +R+ + A +E
Sbjct: 1989 EAEERVQKSLAAEEEAARQRKAALEE 2014
Score = 40.8 bits (94), Expect = 0.002
Identities = 42/162 (25%), Positives = 76/162 (46%), Gaps = 8/162 (4%)
Query: 117 RQKEAEIT--KKFRDALANEKARILAEKWKVEMEDRKAAKVLEERIHEEFKRKE---EEE 171
RQ E EI K + A KA + E ++ + E+ E ++++ EEE
Sbjct: 1925 RQVEEEILALKASFEKAAAGKAELELELGRIRSNAEDTLRSKEQAELEAARQRQLAAEEE 1984
Query: 172 RKRGEEQIRLQEEQRAKELYWTLKQAQLHCQASEKEEREWEEQLRRSKAADEERSRRAQR 231
R+R E + R+Q+ A+E +Q + + E+ + + EE R + A++E +R+ Q
Sbjct: 1985 RRRREAEERVQKSLAAEE--EAARQRKAALEEVERLKAKVEEARRLRERAEQESARQLQL 2042
Query: 232 ARDEYRHHSLRAIQKGTVAGLSSMFRELGQSHEQEARLYHHL 273
A+ E L+A +K + +EL Q+ +QE + L
Sbjct: 2043 AQ-EAAQKRLQAEEKAHAFAVQQKEQELQQTLQQEQSVLDQL 2083
Score = 39.7 bits (91), Expect = 0.004
Identities = 32/145 (22%), Positives = 70/145 (48%), Gaps = 5/145 (3%)
Query: 93 EEISEELIAERARLQAQREAEELWRQKEA-EITKKFRDALANEKARILAEKWKVEMEDRK 151
E E+L E LQ + E + +Q++ + T+ + + +EK +L + +E E K
Sbjct: 2460 EREKEKLQQEAKLLQLKSEEMQTVQQEQLLQETQALQQSFLSEKDSLLQRERFIEQEKAK 2519
Query: 152 AAKVLEERIHEEFKRKEEEERKRGEEQIRLQEEQRAKELYWTLKQAQLHCQASEKEEREW 211
++ ++ + + + +EE++R ++Q QE QR ++ Q + + ++E
Sbjct: 2520 LEQLFQDEVAKAQQLREEQQR---QQQQMEQERQRLVASMEEARRRQHEAEEGVRRKQEE 2576
Query: 212 EEQLRRSKAADEE-RSRRAQRARDE 235
+QL + + EE + QR R++
Sbjct: 2577 LQQLEQQRRQQEELLAEENQRLREQ 2601
Score = 37.7 bits (86), Expect = 0.016
Identities = 46/172 (26%), Positives = 77/172 (44%), Gaps = 24/172 (13%)
Query: 97 EELIAERARLQAQ--------REAEELWRQKEAEITKKFRDALANEKARILAEKWK---- 144
E+L+ E LQ + E Q++A++ + F+D +A KA+ L E+ +
Sbjct: 2486 EQLLQETQALQQSFLSEKDSLLQRERFIEQEKAKLEQLFQDEVA--KAQQLREEQQRQQQ 2543
Query: 145 -VEMEDRKAAKVLEE---RIHE--EFKRKEEEERKRGEEQIRLQEEQRAKELYWTLKQAQ 198
+E E ++ +EE R HE E R+++EE ++ E+Q R QEE A+E +Q Q
Sbjct: 2544 QMEQERQRLVASMEEARRRQHEAEEGVRRKQEELQQLEQQRRQQEELLAEENQRLREQLQ 2603
Query: 199 L----HCQASEKEEREWEEQLRRSKAADEERSRRAQRARDEYRHHSLRAIQK 246
L H A E Q+ +K R A + HS +++
Sbjct: 2604 LLEEQHRAALAHSEEVTASQVAATKTLPNGRDALDGPAAEAEPEHSFDGLRR 2655
Score = 35.0 bits (79), Expect = 0.10
Identities = 35/172 (20%), Positives = 79/172 (45%), Gaps = 4/172 (2%)
Query: 97 EELIAERARLQAQREAEELWRQKEAEITKKFRDALANEKARILAEKWKVEMEDRKAAKVL 156
EEL +AR++A+ A L ++ + T++F A + ++ E ++ + ++AA++
Sbjct: 2242 EELSKLKARIEAENRALIL---RDKDNTQRFLQEEAEKMKQVAEEAARLSVAAQEAARLR 2298
Query: 157 EERIHEEFKRKEEEERKRGEEQIRLQEEQRAKELYWTLKQAQLHCQASEKEEREWEEQLR 216
+ + +++ E+ E+ +QE R K L+Q + Q + +E +EQ+
Sbjct: 2299 QLAEEDLAQQRALAEKMLKEKMQAVQEATRLKAEAELLQQQKELAQEQARRLQEDKEQMA 2358
Query: 217 RSKAADEERSRRAQRARDEYRHHSLRAIQKGTVAGLSSMFRELGQSHEQEAR 268
+ A + + +R A + R + A + ++ M R ++ E R
Sbjct: 2359 QQLAEETQGFQRTLEA-ERQRQLEMSAEAERLKLRVAEMSRAQARAEEDAQR 2409
Score = 34.7 bits (78), Expect = 0.13
Identities = 47/191 (24%), Positives = 84/191 (43%), Gaps = 22/191 (11%)
Query: 101 AERARLQAQREAEELWRQKEAEITKKFRDALANEKARILAE-----KWKVEMEDRKAAKV 155
AE+ R +A++EA + ++A + +K EK + AE K +VE E
Sbjct: 2139 AEKLRKEAEQEAARRAQAEQAALRQKQAADAEMEKHKKFAEQTLRQKAQVEQELTTLRLQ 2198
Query: 156 LEERIH------EEFKRKEEE------ERKRGEEQ---IRLQEEQRAK-ELYWTLKQAQL 199
LEE H EE +R + E +R + EE+ +R+Q E+ +K + + L
Sbjct: 2199 LEETDHQKNLLDEELQRLKAEATEAARQRSQVEEELFSVRVQMEELSKLKARIEAENRAL 2258
Query: 200 HCQASEKEEREWEEQLRRSKAADEERSRRAQRARDEYRHHSLRAIQKGTVAGLS-SMFRE 258
+ + +R +E+ + K EE +R + A++ R L L+ M +E
Sbjct: 2259 ILRDKDNTQRFLQEEAEKMKQVAEEAARLSVAAQEAARLRQLAEEDLAQQRALAEKMLKE 2318
Query: 259 LGQSHEQEARL 269
Q+ ++ RL
Sbjct: 2319 KMQAVQEATRL 2329
>gi|41322919 plectin 1 isoform 8 [Homo sapiens]
Length = 4547
Score = 55.5 bits (132), Expect = 7e-08
Identities = 63/237 (26%), Positives = 111/237 (46%), Gaps = 31/237 (13%)
Query: 17 AELSDVQKHILFYKMREEQLRRWKERETWEA-----LAQDEGLRPPKTKRAA-------S 64
A L +V++ K + E+ RR +ER E+ LAQ+ + + + A
Sbjct: 2006 AALEEVER----LKAKVEEARRLRERAEQESARQLQLAQEAAQKRLQAEEKAHAFAVQQK 2061
Query: 65 DKHIQWLLGADGEVWVWIMGEGPGDKPYEEISEELIAERARLQAQREAEELWRQ-KEAEI 123
++ +Q L + V + GE + E +EE AR+QA+REA + RQ +EAE
Sbjct: 2062 EQELQQTLQQEQSVLDQLRGEAEAARRAAEEAEE-----ARVQAEREAAQSRRQVEEAER 2116
Query: 124 TKKFRD--ALANEKARILAEKWKVEMEDRKAAKVLEERI---HEEFKRKEEEERKRGEEQ 178
K+ + A A +A+ AEK + E E A + E+ ++ E E+ K+ EQ
Sbjct: 2117 LKQSAEEQAQARAQAQAAAEKLRKEAEQEAARRAQAEQAALRQKQAADAEMEKHKKFAEQ 2176
Query: 179 IRLQEEQRAKELYWTLKQAQLHCQASEKEEREWEEQLRRSKAADEERSRRAQRARDE 235
Q+ Q +E L +L + ++ ++ +E+L+R KA E +R+ + +E
Sbjct: 2177 TLRQKAQVEQE----LTTLRLQLEETDHQKNLLDEELQRLKAEATEAARQRSQVEEE 2229
Score = 46.6 bits (109), Expect = 3e-05
Identities = 67/271 (24%), Positives = 111/271 (40%), Gaps = 36/271 (13%)
Query: 28 FYKMREEQLRRWKERETWEALAQDEGLRPPKTKRAASDKHIQWLLGADGEVWVWIMGEGP 87
+ K E LRR +E E + E AA +K Q A+ E
Sbjct: 1333 YIKFISETLRRMEEEERLAEQQRAEERERLAEVEAALEKQRQL---AEAHAQAKAQAERE 1389
Query: 88 GDKPYEEISEELI--------AERARLQAQREAEELWRQKEAEITKKFRDALANEKARIL 139
+ + + EE++ A++ + Q E ++L + EAEI K R A A E++R+
Sbjct: 1390 AKELQQRMQEEVVRREEAAVDAQQQKRSIQEELQQLRQSSEAEIQAKARQAEAAERSRLR 1449
Query: 140 AE------KWKVEMEDRKAAKVLEERIHEEFKRKEEEERKR--GEEQIRLQ-----EEQR 186
E + ++E +R+ E + +E E +KR EE RL+ E QR
Sbjct: 1450 IEEEIRVVRLQLEATERQRGGAEGELQALRARAEEAEAQKRQAQEEAERLRRQVQDESQR 1509
Query: 187 AKELYWTL-----------KQAQLHCQASEKEEREWEEQLRRSKAADEERSRRAQRARDE 235
++ L ++ Q QA E+ + EE RR + A+ ER+R+ Q A E
Sbjct: 1510 KRQAEVELASRVKAEAEAAREKQRALQALEELRLQAEEAERRLRQAEVERARQVQVAL-E 1568
Query: 236 YRHHSLRAIQKGTVAGLSSMFRELGQSHEQE 266
S A + A + +L +S ++E
Sbjct: 1569 TAQRSAEAELQSKRASFAEKTAQLERSLQEE 1599
Score = 43.5 bits (101), Expect = 3e-04
Identities = 44/151 (29%), Positives = 73/151 (48%), Gaps = 8/151 (5%)
Query: 102 ERARLQAQREAEELWRQKEAEITKKFRDALANEKARI---LAEKWKVEMEDRKAAKVLEE 158
ERAR Q Q E R EAE+ K R + A + A++ L E+ + R+ A+ +
Sbjct: 1558 ERAR-QVQVALETAQRSAEAELQSK-RASFAEKTAQLERSLQEEHVAVAQLREEAERRAQ 1615
Query: 159 RIHEEFKRKEEEERKRGEEQIRLQEEQRAKELYWTLKQAQLHCQA-SEKEEREWEEQLRR 217
+ E + +EE ER+ Q++ E R + + Q + QA +EK++ E E + RR
Sbjct: 1616 QQAEAERAREEAERELERWQLKANEALRLRLQAEEVAQQKSLAQAEAEKQKEEAEREARR 1675
Query: 218 SKAADEERSRRAQRARDEYRHHSLRAIQKGT 248
A+E+ R+ + A E R + +GT
Sbjct: 1676 RGKAEEQAVRQRELAEQELEKQ--RQLAEGT 1704
Score = 43.1 bits (100), Expect = 4e-04
Identities = 56/213 (26%), Positives = 92/213 (43%), Gaps = 41/213 (19%)
Query: 93 EEISEELIAERARLQAQREAEELWRQKEAEITKKFRDALANEKARIL------------- 139
E ++ + E A +AQ++AE ++EAE + ANE R+
Sbjct: 1599 EHVAVAQLREEAERRAQQQAEAERAREEAERELERWQLKANEALRLRLQAEEVAQQKSLA 1658
Query: 140 ---AEKWK--VEMEDRKAAKVLEERIHEEFKRKEEEERKR-------------GEEQIRL 181
AEK K E E R+ K E+ + + ++E E++R +E IRL
Sbjct: 1659 QAEAEKQKEEAEREARRRGKAEEQAVRQRELAEQELEKQRQLAEGTAQQRLAAEQELIRL 1718
Query: 182 -----QEEQRAKELYWTLKQAQLHCQASEKEEREWEEQLRRSKAADEERSRRAQRARDEY 236
Q EQ+ + L L + Q A+ ++ +E E +L + +A E RA +E
Sbjct: 1719 RAETEQGEQQRQLLEEELARLQREAAAATQKRQELEAELAKVRAEMEVLLASKARAEEES 1778
Query: 237 RHHSLRAIQKGTVAGLSSMFRELGQSHEQEARL 269
R S ++ Q+ + + FREL E+ ARL
Sbjct: 1779 RSTSEKSKQR--LEAEAGRFRELA---EEAARL 1806
Score = 41.6 bits (96), Expect = 0.001
Identities = 54/206 (26%), Positives = 96/206 (46%), Gaps = 16/206 (7%)
Query: 40 KERETWEALAQDEGLRPPKTKRAASDKHIQWLLGADGEVWVWIMGEGPGDKPYEEISEEL 99
+E + LA+++ R +RA +++ + L A GE K E +E L
Sbjct: 1811 EEAKRQRQLAEEDAAR----QRAEAERVLAEKLAAIGEATRLKTEAEIALKEKEAENERL 1866
Query: 100 --IAERARLQAQREAEELWRQKEAEITKKFRDALANEKARILAEKWKVEMEDRKAAKVLE 157
+AE Q +R EE Q +A+I ++ + + +K VE R+ +V E
Sbjct: 1867 RRLAEDEAFQ-RRRLEEQAAQHKADIEERLAQLRKASDSELERQKGLVEDTLRQRRQVEE 1925
Query: 158 E--RIHEEFKR----KEEEERKRGEEQIRLQEEQRAKEL--YWTLKQAQLHCQASEKEER 209
E + F++ K E E + G + ++ R+KE +Q QL + E+ R
Sbjct: 1926 EILALKASFEKAAAGKAELELELGRIRSNAEDTLRSKEQAELEAARQRQLAAE-EERRRR 1984
Query: 210 EWEEQLRRSKAADEERSRRAQRARDE 235
E EE++++S AA+EE +R+ + A +E
Sbjct: 1985 EAEERVQKSLAAEEEAARQRKAALEE 2010
Score = 40.8 bits (94), Expect = 0.002
Identities = 42/162 (25%), Positives = 76/162 (46%), Gaps = 8/162 (4%)
Query: 117 RQKEAEIT--KKFRDALANEKARILAEKWKVEMEDRKAAKVLEERIHEEFKRKE---EEE 171
RQ E EI K + A KA + E ++ + E+ E ++++ EEE
Sbjct: 1921 RQVEEEILALKASFEKAAAGKAELELELGRIRSNAEDTLRSKEQAELEAARQRQLAAEEE 1980
Query: 172 RKRGEEQIRLQEEQRAKELYWTLKQAQLHCQASEKEEREWEEQLRRSKAADEERSRRAQR 231
R+R E + R+Q+ A+E +Q + + E+ + + EE R + A++E +R+ Q
Sbjct: 1981 RRRREAEERVQKSLAAEE--EAARQRKAALEEVERLKAKVEEARRLRERAEQESARQLQL 2038
Query: 232 ARDEYRHHSLRAIQKGTVAGLSSMFRELGQSHEQEARLYHHL 273
A+ E L+A +K + +EL Q+ +QE + L
Sbjct: 2039 AQ-EAAQKRLQAEEKAHAFAVQQKEQELQQTLQQEQSVLDQL 2079
Score = 39.7 bits (91), Expect = 0.004
Identities = 32/145 (22%), Positives = 70/145 (48%), Gaps = 5/145 (3%)
Query: 93 EEISEELIAERARLQAQREAEELWRQKEA-EITKKFRDALANEKARILAEKWKVEMEDRK 151
E E+L E LQ + E + +Q++ + T+ + + +EK +L + +E E K
Sbjct: 2456 EREKEKLQQEAKLLQLKSEEMQTVQQEQLLQETQALQQSFLSEKDSLLQRERFIEQEKAK 2515
Query: 152 AAKVLEERIHEEFKRKEEEERKRGEEQIRLQEEQRAKELYWTLKQAQLHCQASEKEEREW 211
++ ++ + + + +EE++R ++Q QE QR ++ Q + + ++E
Sbjct: 2516 LEQLFQDEVAKAQQLREEQQR---QQQQMEQERQRLVASMEEARRRQHEAEEGVRRKQEE 2572
Query: 212 EEQLRRSKAADEE-RSRRAQRARDE 235
+QL + + EE + QR R++
Sbjct: 2573 LQQLEQQRRQQEELLAEENQRLREQ 2597
Score = 37.7 bits (86), Expect = 0.016
Identities = 46/172 (26%), Positives = 77/172 (44%), Gaps = 24/172 (13%)
Query: 97 EELIAERARLQAQ--------REAEELWRQKEAEITKKFRDALANEKARILAEKWK---- 144
E+L+ E LQ + E Q++A++ + F+D +A KA+ L E+ +
Sbjct: 2482 EQLLQETQALQQSFLSEKDSLLQRERFIEQEKAKLEQLFQDEVA--KAQQLREEQQRQQQ 2539
Query: 145 -VEMEDRKAAKVLEE---RIHE--EFKRKEEEERKRGEEQIRLQEEQRAKELYWTLKQAQ 198
+E E ++ +EE R HE E R+++EE ++ E+Q R QEE A+E +Q Q
Sbjct: 2540 QMEQERQRLVASMEEARRRQHEAEEGVRRKQEELQQLEQQRRQQEELLAEENQRLREQLQ 2599
Query: 199 L----HCQASEKEEREWEEQLRRSKAADEERSRRAQRARDEYRHHSLRAIQK 246
L H A E Q+ +K R A + HS +++
Sbjct: 2600 LLEEQHRAALAHSEEVTASQVAATKTLPNGRDALDGPAAEAEPEHSFDGLRR 2651
Score = 35.0 bits (79), Expect = 0.10
Identities = 35/172 (20%), Positives = 79/172 (45%), Gaps = 4/172 (2%)
Query: 97 EELIAERARLQAQREAEELWRQKEAEITKKFRDALANEKARILAEKWKVEMEDRKAAKVL 156
EEL +AR++A+ A L ++ + T++F A + ++ E ++ + ++AA++
Sbjct: 2238 EELSKLKARIEAENRALIL---RDKDNTQRFLQEEAEKMKQVAEEAARLSVAAQEAARLR 2294
Query: 157 EERIHEEFKRKEEEERKRGEEQIRLQEEQRAKELYWTLKQAQLHCQASEKEEREWEEQLR 216
+ + +++ E+ E+ +QE R K L+Q + Q + +E +EQ+
Sbjct: 2295 QLAEEDLAQQRALAEKMLKEKMQAVQEATRLKAEAELLQQQKELAQEQARRLQEDKEQMA 2354
Query: 217 RSKAADEERSRRAQRARDEYRHHSLRAIQKGTVAGLSSMFRELGQSHEQEAR 268
+ A + + +R A + R + A + ++ M R ++ E R
Sbjct: 2355 QQLAEETQGFQRTLEA-ERQRQLEMSAEAERLKLRVAEMSRAQARAEEDAQR 2405
Score = 34.7 bits (78), Expect = 0.13
Identities = 47/191 (24%), Positives = 84/191 (43%), Gaps = 22/191 (11%)
Query: 101 AERARLQAQREAEELWRQKEAEITKKFRDALANEKARILAE-----KWKVEMEDRKAAKV 155
AE+ R +A++EA + ++A + +K EK + AE K +VE E
Sbjct: 2135 AEKLRKEAEQEAARRAQAEQAALRQKQAADAEMEKHKKFAEQTLRQKAQVEQELTTLRLQ 2194
Query: 156 LEERIH------EEFKRKEEE------ERKRGEEQ---IRLQEEQRAK-ELYWTLKQAQL 199
LEE H EE +R + E +R + EE+ +R+Q E+ +K + + L
Sbjct: 2195 LEETDHQKNLLDEELQRLKAEATEAARQRSQVEEELFSVRVQMEELSKLKARIEAENRAL 2254
Query: 200 HCQASEKEEREWEEQLRRSKAADEERSRRAQRARDEYRHHSLRAIQKGTVAGLS-SMFRE 258
+ + +R +E+ + K EE +R + A++ R L L+ M +E
Sbjct: 2255 ILRDKDNTQRFLQEEAEKMKQVAEEAARLSVAAQEAARLRQLAEEDLAQQRALAEKMLKE 2314
Query: 259 LGQSHEQEARL 269
Q+ ++ RL
Sbjct: 2315 KMQAVQEATRL 2325
>gi|41322910 plectin 1 isoform 7 [Homo sapiens]
Length = 4515
Score = 55.5 bits (132), Expect = 7e-08
Identities = 63/237 (26%), Positives = 111/237 (46%), Gaps = 31/237 (13%)
Query: 17 AELSDVQKHILFYKMREEQLRRWKERETWEA-----LAQDEGLRPPKTKRAA-------S 64
A L +V++ K + E+ RR +ER E+ LAQ+ + + + A
Sbjct: 1974 AALEEVER----LKAKVEEARRLRERAEQESARQLQLAQEAAQKRLQAEEKAHAFAVQQK 2029
Query: 65 DKHIQWLLGADGEVWVWIMGEGPGDKPYEEISEELIAERARLQAQREAEELWRQ-KEAEI 123
++ +Q L + V + GE + E +EE AR+QA+REA + RQ +EAE
Sbjct: 2030 EQELQQTLQQEQSVLDQLRGEAEAARRAAEEAEE-----ARVQAEREAAQSRRQVEEAER 2084
Query: 124 TKKFRD--ALANEKARILAEKWKVEMEDRKAAKVLEERI---HEEFKRKEEEERKRGEEQ 178
K+ + A A +A+ AEK + E E A + E+ ++ E E+ K+ EQ
Sbjct: 2085 LKQSAEEQAQARAQAQAAAEKLRKEAEQEAARRAQAEQAALRQKQAADAEMEKHKKFAEQ 2144
Query: 179 IRLQEEQRAKELYWTLKQAQLHCQASEKEEREWEEQLRRSKAADEERSRRAQRARDE 235
Q+ Q +E L +L + ++ ++ +E+L+R KA E +R+ + +E
Sbjct: 2145 TLRQKAQVEQE----LTTLRLQLEETDHQKNLLDEELQRLKAEATEAARQRSQVEEE 2197
Score = 46.6 bits (109), Expect = 3e-05
Identities = 67/271 (24%), Positives = 111/271 (40%), Gaps = 36/271 (13%)
Query: 28 FYKMREEQLRRWKERETWEALAQDEGLRPPKTKRAASDKHIQWLLGADGEVWVWIMGEGP 87
+ K E LRR +E E + E AA +K Q A+ E
Sbjct: 1301 YIKFISETLRRMEEEERLAEQQRAEERERLAEVEAALEKQRQL---AEAHAQAKAQAERE 1357
Query: 88 GDKPYEEISEELI--------AERARLQAQREAEELWRQKEAEITKKFRDALANEKARIL 139
+ + + EE++ A++ + Q E ++L + EAEI K R A A E++R+
Sbjct: 1358 AKELQQRMQEEVVRREEAAVDAQQQKRSIQEELQQLRQSSEAEIQAKARQAEAAERSRLR 1417
Query: 140 AE------KWKVEMEDRKAAKVLEERIHEEFKRKEEEERKR--GEEQIRLQ-----EEQR 186
E + ++E +R+ E + +E E +KR EE RL+ E QR
Sbjct: 1418 IEEEIRVVRLQLEATERQRGGAEGELQALRARAEEAEAQKRQAQEEAERLRRQVQDESQR 1477
Query: 187 AKELYWTL-----------KQAQLHCQASEKEEREWEEQLRRSKAADEERSRRAQRARDE 235
++ L ++ Q QA E+ + EE RR + A+ ER+R+ Q A E
Sbjct: 1478 KRQAEVELASRVKAEAEAAREKQRALQALEELRLQAEEAERRLRQAEVERARQVQVAL-E 1536
Query: 236 YRHHSLRAIQKGTVAGLSSMFRELGQSHEQE 266
S A + A + +L +S ++E
Sbjct: 1537 TAQRSAEAELQSKRASFAEKTAQLERSLQEE 1567
Score = 43.5 bits (101), Expect = 3e-04
Identities = 44/151 (29%), Positives = 73/151 (48%), Gaps = 8/151 (5%)
Query: 102 ERARLQAQREAEELWRQKEAEITKKFRDALANEKARI---LAEKWKVEMEDRKAAKVLEE 158
ERAR Q Q E R EAE+ K R + A + A++ L E+ + R+ A+ +
Sbjct: 1526 ERAR-QVQVALETAQRSAEAELQSK-RASFAEKTAQLERSLQEEHVAVAQLREEAERRAQ 1583
Query: 159 RIHEEFKRKEEEERKRGEEQIRLQEEQRAKELYWTLKQAQLHCQA-SEKEEREWEEQLRR 217
+ E + +EE ER+ Q++ E R + + Q + QA +EK++ E E + RR
Sbjct: 1584 QQAEAERAREEAERELERWQLKANEALRLRLQAEEVAQQKSLAQAEAEKQKEEAEREARR 1643
Query: 218 SKAADEERSRRAQRARDEYRHHSLRAIQKGT 248
A+E+ R+ + A E R + +GT
Sbjct: 1644 RGKAEEQAVRQRELAEQELEKQ--RQLAEGT 1672
Score = 43.1 bits (100), Expect = 4e-04
Identities = 56/213 (26%), Positives = 92/213 (43%), Gaps = 41/213 (19%)
Query: 93 EEISEELIAERARLQAQREAEELWRQKEAEITKKFRDALANEKARIL------------- 139
E ++ + E A +AQ++AE ++EAE + ANE R+
Sbjct: 1567 EHVAVAQLREEAERRAQQQAEAERAREEAERELERWQLKANEALRLRLQAEEVAQQKSLA 1626
Query: 140 ---AEKWK--VEMEDRKAAKVLEERIHEEFKRKEEEERKR-------------GEEQIRL 181
AEK K E E R+ K E+ + + ++E E++R +E IRL
Sbjct: 1627 QAEAEKQKEEAEREARRRGKAEEQAVRQRELAEQELEKQRQLAEGTAQQRLAAEQELIRL 1686
Query: 182 -----QEEQRAKELYWTLKQAQLHCQASEKEEREWEEQLRRSKAADEERSRRAQRARDEY 236
Q EQ+ + L L + Q A+ ++ +E E +L + +A E RA +E
Sbjct: 1687 RAETEQGEQQRQLLEEELARLQREAAAATQKRQELEAELAKVRAEMEVLLASKARAEEES 1746
Query: 237 RHHSLRAIQKGTVAGLSSMFRELGQSHEQEARL 269
R S ++ Q+ + + FREL E+ ARL
Sbjct: 1747 RSTSEKSKQR--LEAEAGRFRELA---EEAARL 1774
Score = 41.6 bits (96), Expect = 0.001
Identities = 54/206 (26%), Positives = 96/206 (46%), Gaps = 16/206 (7%)
Query: 40 KERETWEALAQDEGLRPPKTKRAASDKHIQWLLGADGEVWVWIMGEGPGDKPYEEISEEL 99
+E + LA+++ R +RA +++ + L A GE K E +E L
Sbjct: 1779 EEAKRQRQLAEEDAAR----QRAEAERVLAEKLAAIGEATRLKTEAEIALKEKEAENERL 1834
Query: 100 --IAERARLQAQREAEELWRQKEAEITKKFRDALANEKARILAEKWKVEMEDRKAAKVLE 157
+AE Q +R EE Q +A+I ++ + + +K VE R+ +V E
Sbjct: 1835 RRLAEDEAFQ-RRRLEEQAAQHKADIEERLAQLRKASDSELERQKGLVEDTLRQRRQVEE 1893
Query: 158 E--RIHEEFKR----KEEEERKRGEEQIRLQEEQRAKEL--YWTLKQAQLHCQASEKEER 209
E + F++ K E E + G + ++ R+KE +Q QL + E+ R
Sbjct: 1894 EILALKASFEKAAAGKAELELELGRIRSNAEDTLRSKEQAELEAARQRQLAAE-EERRRR 1952
Query: 210 EWEEQLRRSKAADEERSRRAQRARDE 235
E EE++++S AA+EE +R+ + A +E
Sbjct: 1953 EAEERVQKSLAAEEEAARQRKAALEE 1978
Score = 40.8 bits (94), Expect = 0.002
Identities = 42/162 (25%), Positives = 76/162 (46%), Gaps = 8/162 (4%)
Query: 117 RQKEAEIT--KKFRDALANEKARILAEKWKVEMEDRKAAKVLEERIHEEFKRKE---EEE 171
RQ E EI K + A KA + E ++ + E+ E ++++ EEE
Sbjct: 1889 RQVEEEILALKASFEKAAAGKAELELELGRIRSNAEDTLRSKEQAELEAARQRQLAAEEE 1948
Query: 172 RKRGEEQIRLQEEQRAKELYWTLKQAQLHCQASEKEEREWEEQLRRSKAADEERSRRAQR 231
R+R E + R+Q+ A+E +Q + + E+ + + EE R + A++E +R+ Q
Sbjct: 1949 RRRREAEERVQKSLAAEE--EAARQRKAALEEVERLKAKVEEARRLRERAEQESARQLQL 2006
Query: 232 ARDEYRHHSLRAIQKGTVAGLSSMFRELGQSHEQEARLYHHL 273
A+ E L+A +K + +EL Q+ +QE + L
Sbjct: 2007 AQ-EAAQKRLQAEEKAHAFAVQQKEQELQQTLQQEQSVLDQL 2047
Score = 39.7 bits (91), Expect = 0.004
Identities = 32/145 (22%), Positives = 70/145 (48%), Gaps = 5/145 (3%)
Query: 93 EEISEELIAERARLQAQREAEELWRQKEA-EITKKFRDALANEKARILAEKWKVEMEDRK 151
E E+L E LQ + E + +Q++ + T+ + + +EK +L + +E E K
Sbjct: 2424 EREKEKLQQEAKLLQLKSEEMQTVQQEQLLQETQALQQSFLSEKDSLLQRERFIEQEKAK 2483
Query: 152 AAKVLEERIHEEFKRKEEEERKRGEEQIRLQEEQRAKELYWTLKQAQLHCQASEKEEREW 211
++ ++ + + + +EE++R ++Q QE QR ++ Q + + ++E
Sbjct: 2484 LEQLFQDEVAKAQQLREEQQR---QQQQMEQERQRLVASMEEARRRQHEAEEGVRRKQEE 2540
Query: 212 EEQLRRSKAADEE-RSRRAQRARDE 235
+QL + + EE + QR R++
Sbjct: 2541 LQQLEQQRRQQEELLAEENQRLREQ 2565
Score = 37.7 bits (86), Expect = 0.016
Identities = 46/172 (26%), Positives = 77/172 (44%), Gaps = 24/172 (13%)
Query: 97 EELIAERARLQAQ--------REAEELWRQKEAEITKKFRDALANEKARILAEKWK---- 144
E+L+ E LQ + E Q++A++ + F+D +A KA+ L E+ +
Sbjct: 2450 EQLLQETQALQQSFLSEKDSLLQRERFIEQEKAKLEQLFQDEVA--KAQQLREEQQRQQQ 2507
Query: 145 -VEMEDRKAAKVLEE---RIHE--EFKRKEEEERKRGEEQIRLQEEQRAKELYWTLKQAQ 198
+E E ++ +EE R HE E R+++EE ++ E+Q R QEE A+E +Q Q
Sbjct: 2508 QMEQERQRLVASMEEARRRQHEAEEGVRRKQEELQQLEQQRRQQEELLAEENQRLREQLQ 2567
Query: 199 L----HCQASEKEEREWEEQLRRSKAADEERSRRAQRARDEYRHHSLRAIQK 246
L H A E Q+ +K R A + HS +++
Sbjct: 2568 LLEEQHRAALAHSEEVTASQVAATKTLPNGRDALDGPAAEAEPEHSFDGLRR 2619
Score = 35.0 bits (79), Expect = 0.10
Identities = 35/172 (20%), Positives = 79/172 (45%), Gaps = 4/172 (2%)
Query: 97 EELIAERARLQAQREAEELWRQKEAEITKKFRDALANEKARILAEKWKVEMEDRKAAKVL 156
EEL +AR++A+ A L ++ + T++F A + ++ E ++ + ++AA++
Sbjct: 2206 EELSKLKARIEAENRALIL---RDKDNTQRFLQEEAEKMKQVAEEAARLSVAAQEAARLR 2262
Query: 157 EERIHEEFKRKEEEERKRGEEQIRLQEEQRAKELYWTLKQAQLHCQASEKEEREWEEQLR 216
+ + +++ E+ E+ +QE R K L+Q + Q + +E +EQ+
Sbjct: 2263 QLAEEDLAQQRALAEKMLKEKMQAVQEATRLKAEAELLQQQKELAQEQARRLQEDKEQMA 2322
Query: 217 RSKAADEERSRRAQRARDEYRHHSLRAIQKGTVAGLSSMFRELGQSHEQEAR 268
+ A + + +R A + R + A + ++ M R ++ E R
Sbjct: 2323 QQLAEETQGFQRTLEA-ERQRQLEMSAEAERLKLRVAEMSRAQARAEEDAQR 2373
Score = 34.7 bits (78), Expect = 0.13
Identities = 47/191 (24%), Positives = 84/191 (43%), Gaps = 22/191 (11%)
Query: 101 AERARLQAQREAEELWRQKEAEITKKFRDALANEKARILAE-----KWKVEMEDRKAAKV 155
AE+ R +A++EA + ++A + +K EK + AE K +VE E
Sbjct: 2103 AEKLRKEAEQEAARRAQAEQAALRQKQAADAEMEKHKKFAEQTLRQKAQVEQELTTLRLQ 2162
Query: 156 LEERIH------EEFKRKEEE------ERKRGEEQ---IRLQEEQRAK-ELYWTLKQAQL 199
LEE H EE +R + E +R + EE+ +R+Q E+ +K + + L
Sbjct: 2163 LEETDHQKNLLDEELQRLKAEATEAARQRSQVEEELFSVRVQMEELSKLKARIEAENRAL 2222
Query: 200 HCQASEKEEREWEEQLRRSKAADEERSRRAQRARDEYRHHSLRAIQKGTVAGLS-SMFRE 258
+ + +R +E+ + K EE +R + A++ R L L+ M +E
Sbjct: 2223 ILRDKDNTQRFLQEEAEKMKQVAEEAARLSVAAQEAARLRQLAEEDLAQQRALAEKMLKE 2282
Query: 259 LGQSHEQEARL 269
Q+ ++ RL
Sbjct: 2283 KMQAVQEATRL 2293
>gi|41322916 plectin 1 isoform 6 [Homo sapiens]
Length = 4684
Score = 55.5 bits (132), Expect = 7e-08
Identities = 63/237 (26%), Positives = 111/237 (46%), Gaps = 31/237 (13%)
Query: 17 AELSDVQKHILFYKMREEQLRRWKERETWEA-----LAQDEGLRPPKTKRAA-------S 64
A L +V++ K + E+ RR +ER E+ LAQ+ + + + A
Sbjct: 2143 AALEEVER----LKAKVEEARRLRERAEQESARQLQLAQEAAQKRLQAEEKAHAFAVQQK 2198
Query: 65 DKHIQWLLGADGEVWVWIMGEGPGDKPYEEISEELIAERARLQAQREAEELWRQ-KEAEI 123
++ +Q L + V + GE + E +EE AR+QA+REA + RQ +EAE
Sbjct: 2199 EQELQQTLQQEQSVLDQLRGEAEAARRAAEEAEE-----ARVQAEREAAQSRRQVEEAER 2253
Query: 124 TKKFRD--ALANEKARILAEKWKVEMEDRKAAKVLEERI---HEEFKRKEEEERKRGEEQ 178
K+ + A A +A+ AEK + E E A + E+ ++ E E+ K+ EQ
Sbjct: 2254 LKQSAEEQAQARAQAQAAAEKLRKEAEQEAARRAQAEQAALRQKQAADAEMEKHKKFAEQ 2313
Query: 179 IRLQEEQRAKELYWTLKQAQLHCQASEKEEREWEEQLRRSKAADEERSRRAQRARDE 235
Q+ Q +E L +L + ++ ++ +E+L+R KA E +R+ + +E
Sbjct: 2314 TLRQKAQVEQE----LTTLRLQLEETDHQKNLLDEELQRLKAEATEAARQRSQVEEE 2366
Score = 46.6 bits (109), Expect = 3e-05
Identities = 67/271 (24%), Positives = 111/271 (40%), Gaps = 36/271 (13%)
Query: 28 FYKMREEQLRRWKERETWEALAQDEGLRPPKTKRAASDKHIQWLLGADGEVWVWIMGEGP 87
+ K E LRR +E E + E AA +K Q A+ E
Sbjct: 1470 YIKFISETLRRMEEEERLAEQQRAEERERLAEVEAALEKQRQL---AEAHAQAKAQAERE 1526
Query: 88 GDKPYEEISEELI--------AERARLQAQREAEELWRQKEAEITKKFRDALANEKARIL 139
+ + + EE++ A++ + Q E ++L + EAEI K R A A E++R+
Sbjct: 1527 AKELQQRMQEEVVRREEAAVDAQQQKRSIQEELQQLRQSSEAEIQAKARQAEAAERSRLR 1586
Query: 140 AE------KWKVEMEDRKAAKVLEERIHEEFKRKEEEERKR--GEEQIRLQ-----EEQR 186
E + ++E +R+ E + +E E +KR EE RL+ E QR
Sbjct: 1587 IEEEIRVVRLQLEATERQRGGAEGELQALRARAEEAEAQKRQAQEEAERLRRQVQDESQR 1646
Query: 187 AKELYWTL-----------KQAQLHCQASEKEEREWEEQLRRSKAADEERSRRAQRARDE 235
++ L ++ Q QA E+ + EE RR + A+ ER+R+ Q A E
Sbjct: 1647 KRQAEVELASRVKAEAEAAREKQRALQALEELRLQAEEAERRLRQAEVERARQVQVAL-E 1705
Query: 236 YRHHSLRAIQKGTVAGLSSMFRELGQSHEQE 266
S A + A + +L +S ++E
Sbjct: 1706 TAQRSAEAELQSKRASFAEKTAQLERSLQEE 1736
Score = 43.5 bits (101), Expect = 3e-04
Identities = 44/151 (29%), Positives = 73/151 (48%), Gaps = 8/151 (5%)
Query: 102 ERARLQAQREAEELWRQKEAEITKKFRDALANEKARI---LAEKWKVEMEDRKAAKVLEE 158
ERAR Q Q E R EAE+ K R + A + A++ L E+ + R+ A+ +
Sbjct: 1695 ERAR-QVQVALETAQRSAEAELQSK-RASFAEKTAQLERSLQEEHVAVAQLREEAERRAQ 1752
Query: 159 RIHEEFKRKEEEERKRGEEQIRLQEEQRAKELYWTLKQAQLHCQA-SEKEEREWEEQLRR 217
+ E + +EE ER+ Q++ E R + + Q + QA +EK++ E E + RR
Sbjct: 1753 QQAEAERAREEAERELERWQLKANEALRLRLQAEEVAQQKSLAQAEAEKQKEEAEREARR 1812
Query: 218 SKAADEERSRRAQRARDEYRHHSLRAIQKGT 248
A+E+ R+ + A E R + +GT
Sbjct: 1813 RGKAEEQAVRQRELAEQELEKQ--RQLAEGT 1841
Score = 43.1 bits (100), Expect = 4e-04
Identities = 56/213 (26%), Positives = 92/213 (43%), Gaps = 41/213 (19%)
Query: 93 EEISEELIAERARLQAQREAEELWRQKEAEITKKFRDALANEKARIL------------- 139
E ++ + E A +AQ++AE ++EAE + ANE R+
Sbjct: 1736 EHVAVAQLREEAERRAQQQAEAERAREEAERELERWQLKANEALRLRLQAEEVAQQKSLA 1795
Query: 140 ---AEKWK--VEMEDRKAAKVLEERIHEEFKRKEEEERKR-------------GEEQIRL 181
AEK K E E R+ K E+ + + ++E E++R +E IRL
Sbjct: 1796 QAEAEKQKEEAEREARRRGKAEEQAVRQRELAEQELEKQRQLAEGTAQQRLAAEQELIRL 1855
Query: 182 -----QEEQRAKELYWTLKQAQLHCQASEKEEREWEEQLRRSKAADEERSRRAQRARDEY 236
Q EQ+ + L L + Q A+ ++ +E E +L + +A E RA +E
Sbjct: 1856 RAETEQGEQQRQLLEEELARLQREAAAATQKRQELEAELAKVRAEMEVLLASKARAEEES 1915
Query: 237 RHHSLRAIQKGTVAGLSSMFRELGQSHEQEARL 269
R S ++ Q+ + + FREL E+ ARL
Sbjct: 1916 RSTSEKSKQR--LEAEAGRFRELA---EEAARL 1943
Score = 41.6 bits (96), Expect = 0.001
Identities = 54/206 (26%), Positives = 96/206 (46%), Gaps = 16/206 (7%)
Query: 40 KERETWEALAQDEGLRPPKTKRAASDKHIQWLLGADGEVWVWIMGEGPGDKPYEEISEEL 99
+E + LA+++ R +RA +++ + L A GE K E +E L
Sbjct: 1948 EEAKRQRQLAEEDAAR----QRAEAERVLAEKLAAIGEATRLKTEAEIALKEKEAENERL 2003
Query: 100 --IAERARLQAQREAEELWRQKEAEITKKFRDALANEKARILAEKWKVEMEDRKAAKVLE 157
+AE Q +R EE Q +A+I ++ + + +K VE R+ +V E
Sbjct: 2004 RRLAEDEAFQ-RRRLEEQAAQHKADIEERLAQLRKASDSELERQKGLVEDTLRQRRQVEE 2062
Query: 158 E--RIHEEFKR----KEEEERKRGEEQIRLQEEQRAKEL--YWTLKQAQLHCQASEKEER 209
E + F++ K E E + G + ++ R+KE +Q QL + E+ R
Sbjct: 2063 EILALKASFEKAAAGKAELELELGRIRSNAEDTLRSKEQAELEAARQRQLAAE-EERRRR 2121
Query: 210 EWEEQLRRSKAADEERSRRAQRARDE 235
E EE++++S AA+EE +R+ + A +E
Sbjct: 2122 EAEERVQKSLAAEEEAARQRKAALEE 2147
Score = 40.8 bits (94), Expect = 0.002
Identities = 42/162 (25%), Positives = 76/162 (46%), Gaps = 8/162 (4%)
Query: 117 RQKEAEIT--KKFRDALANEKARILAEKWKVEMEDRKAAKVLEERIHEEFKRKE---EEE 171
RQ E EI K + A KA + E ++ + E+ E ++++ EEE
Sbjct: 2058 RQVEEEILALKASFEKAAAGKAELELELGRIRSNAEDTLRSKEQAELEAARQRQLAAEEE 2117
Query: 172 RKRGEEQIRLQEEQRAKELYWTLKQAQLHCQASEKEEREWEEQLRRSKAADEERSRRAQR 231
R+R E + R+Q+ A+E +Q + + E+ + + EE R + A++E +R+ Q
Sbjct: 2118 RRRREAEERVQKSLAAEE--EAARQRKAALEEVERLKAKVEEARRLRERAEQESARQLQL 2175
Query: 232 ARDEYRHHSLRAIQKGTVAGLSSMFRELGQSHEQEARLYHHL 273
A+ E L+A +K + +EL Q+ +QE + L
Sbjct: 2176 AQ-EAAQKRLQAEEKAHAFAVQQKEQELQQTLQQEQSVLDQL 2216
Score = 39.7 bits (91), Expect = 0.004
Identities = 32/145 (22%), Positives = 70/145 (48%), Gaps = 5/145 (3%)
Query: 93 EEISEELIAERARLQAQREAEELWRQKEA-EITKKFRDALANEKARILAEKWKVEMEDRK 151
E E+L E LQ + E + +Q++ + T+ + + +EK +L + +E E K
Sbjct: 2593 EREKEKLQQEAKLLQLKSEEMQTVQQEQLLQETQALQQSFLSEKDSLLQRERFIEQEKAK 2652
Query: 152 AAKVLEERIHEEFKRKEEEERKRGEEQIRLQEEQRAKELYWTLKQAQLHCQASEKEEREW 211
++ ++ + + + +EE++R ++Q QE QR ++ Q + + ++E
Sbjct: 2653 LEQLFQDEVAKAQQLREEQQR---QQQQMEQERQRLVASMEEARRRQHEAEEGVRRKQEE 2709
Query: 212 EEQLRRSKAADEE-RSRRAQRARDE 235
+QL + + EE + QR R++
Sbjct: 2710 LQQLEQQRRQQEELLAEENQRLREQ 2734
Score = 37.7 bits (86), Expect = 0.016
Identities = 46/172 (26%), Positives = 77/172 (44%), Gaps = 24/172 (13%)
Query: 97 EELIAERARLQAQ--------REAEELWRQKEAEITKKFRDALANEKARILAEKWK---- 144
E+L+ E LQ + E Q++A++ + F+D +A KA+ L E+ +
Sbjct: 2619 EQLLQETQALQQSFLSEKDSLLQRERFIEQEKAKLEQLFQDEVA--KAQQLREEQQRQQQ 2676
Query: 145 -VEMEDRKAAKVLEE---RIHE--EFKRKEEEERKRGEEQIRLQEEQRAKELYWTLKQAQ 198
+E E ++ +EE R HE E R+++EE ++ E+Q R QEE A+E +Q Q
Sbjct: 2677 QMEQERQRLVASMEEARRRQHEAEEGVRRKQEELQQLEQQRRQQEELLAEENQRLREQLQ 2736
Query: 199 L----HCQASEKEEREWEEQLRRSKAADEERSRRAQRARDEYRHHSLRAIQK 246
L H A E Q+ +K R A + HS +++
Sbjct: 2737 LLEEQHRAALAHSEEVTASQVAATKTLPNGRDALDGPAAEAEPEHSFDGLRR 2788
Score = 35.0 bits (79), Expect = 0.10
Identities = 35/172 (20%), Positives = 79/172 (45%), Gaps = 4/172 (2%)
Query: 97 EELIAERARLQAQREAEELWRQKEAEITKKFRDALANEKARILAEKWKVEMEDRKAAKVL 156
EEL +AR++A+ A L ++ + T++F A + ++ E ++ + ++AA++
Sbjct: 2375 EELSKLKARIEAENRALIL---RDKDNTQRFLQEEAEKMKQVAEEAARLSVAAQEAARLR 2431
Query: 157 EERIHEEFKRKEEEERKRGEEQIRLQEEQRAKELYWTLKQAQLHCQASEKEEREWEEQLR 216
+ + +++ E+ E+ +QE R K L+Q + Q + +E +EQ+
Sbjct: 2432 QLAEEDLAQQRALAEKMLKEKMQAVQEATRLKAEAELLQQQKELAQEQARRLQEDKEQMA 2491
Query: 217 RSKAADEERSRRAQRARDEYRHHSLRAIQKGTVAGLSSMFRELGQSHEQEAR 268
+ A + + +R A + R + A + ++ M R ++ E R
Sbjct: 2492 QQLAEETQGFQRTLEA-ERQRQLEMSAEAERLKLRVAEMSRAQARAEEDAQR 2542
Score = 34.7 bits (78), Expect = 0.13
Identities = 47/191 (24%), Positives = 84/191 (43%), Gaps = 22/191 (11%)
Query: 101 AERARLQAQREAEELWRQKEAEITKKFRDALANEKARILAE-----KWKVEMEDRKAAKV 155
AE+ R +A++EA + ++A + +K EK + AE K +VE E
Sbjct: 2272 AEKLRKEAEQEAARRAQAEQAALRQKQAADAEMEKHKKFAEQTLRQKAQVEQELTTLRLQ 2331
Query: 156 LEERIH------EEFKRKEEE------ERKRGEEQ---IRLQEEQRAK-ELYWTLKQAQL 199
LEE H EE +R + E +R + EE+ +R+Q E+ +K + + L
Sbjct: 2332 LEETDHQKNLLDEELQRLKAEATEAARQRSQVEEELFSVRVQMEELSKLKARIEAENRAL 2391
Query: 200 HCQASEKEEREWEEQLRRSKAADEERSRRAQRARDEYRHHSLRAIQKGTVAGLS-SMFRE 258
+ + +R +E+ + K EE +R + A++ R L L+ M +E
Sbjct: 2392 ILRDKDNTQRFLQEEAEKMKQVAEEAARLSVAAQEAARLRQLAEEDLAQQRALAEKMLKE 2451
Query: 259 LGQSHEQEARL 269
Q+ ++ RL
Sbjct: 2452 KMQAVQEATRL 2462
>gi|41322908 plectin 1 isoform 3 [Homo sapiens]
Length = 4525
Score = 55.5 bits (132), Expect = 7e-08
Identities = 63/237 (26%), Positives = 111/237 (46%), Gaps = 31/237 (13%)
Query: 17 AELSDVQKHILFYKMREEQLRRWKERETWEA-----LAQDEGLRPPKTKRAA-------S 64
A L +V++ K + E+ RR +ER E+ LAQ+ + + + A
Sbjct: 1984 AALEEVER----LKAKVEEARRLRERAEQESARQLQLAQEAAQKRLQAEEKAHAFAVQQK 2039
Query: 65 DKHIQWLLGADGEVWVWIMGEGPGDKPYEEISEELIAERARLQAQREAEELWRQ-KEAEI 123
++ +Q L + V + GE + E +EE AR+QA+REA + RQ +EAE
Sbjct: 2040 EQELQQTLQQEQSVLDQLRGEAEAARRAAEEAEE-----ARVQAEREAAQSRRQVEEAER 2094
Query: 124 TKKFRD--ALANEKARILAEKWKVEMEDRKAAKVLEERI---HEEFKRKEEEERKRGEEQ 178
K+ + A A +A+ AEK + E E A + E+ ++ E E+ K+ EQ
Sbjct: 2095 LKQSAEEQAQARAQAQAAAEKLRKEAEQEAARRAQAEQAALRQKQAADAEMEKHKKFAEQ 2154
Query: 179 IRLQEEQRAKELYWTLKQAQLHCQASEKEEREWEEQLRRSKAADEERSRRAQRARDE 235
Q+ Q +E L +L + ++ ++ +E+L+R KA E +R+ + +E
Sbjct: 2155 TLRQKAQVEQE----LTTLRLQLEETDHQKNLLDEELQRLKAEATEAARQRSQVEEE 2207
Score = 46.6 bits (109), Expect = 3e-05
Identities = 67/271 (24%), Positives = 111/271 (40%), Gaps = 36/271 (13%)
Query: 28 FYKMREEQLRRWKERETWEALAQDEGLRPPKTKRAASDKHIQWLLGADGEVWVWIMGEGP 87
+ K E LRR +E E + E AA +K Q A+ E
Sbjct: 1311 YIKFISETLRRMEEEERLAEQQRAEERERLAEVEAALEKQRQL---AEAHAQAKAQAERE 1367
Query: 88 GDKPYEEISEELI--------AERARLQAQREAEELWRQKEAEITKKFRDALANEKARIL 139
+ + + EE++ A++ + Q E ++L + EAEI K R A A E++R+
Sbjct: 1368 AKELQQRMQEEVVRREEAAVDAQQQKRSIQEELQQLRQSSEAEIQAKARQAEAAERSRLR 1427
Query: 140 AE------KWKVEMEDRKAAKVLEERIHEEFKRKEEEERKR--GEEQIRLQ-----EEQR 186
E + ++E +R+ E + +E E +KR EE RL+ E QR
Sbjct: 1428 IEEEIRVVRLQLEATERQRGGAEGELQALRARAEEAEAQKRQAQEEAERLRRQVQDESQR 1487
Query: 187 AKELYWTL-----------KQAQLHCQASEKEEREWEEQLRRSKAADEERSRRAQRARDE 235
++ L ++ Q QA E+ + EE RR + A+ ER+R+ Q A E
Sbjct: 1488 KRQAEVELASRVKAEAEAAREKQRALQALEELRLQAEEAERRLRQAEVERARQVQVAL-E 1546
Query: 236 YRHHSLRAIQKGTVAGLSSMFRELGQSHEQE 266
S A + A + +L +S ++E
Sbjct: 1547 TAQRSAEAELQSKRASFAEKTAQLERSLQEE 1577
Score = 43.5 bits (101), Expect = 3e-04
Identities = 44/151 (29%), Positives = 73/151 (48%), Gaps = 8/151 (5%)
Query: 102 ERARLQAQREAEELWRQKEAEITKKFRDALANEKARI---LAEKWKVEMEDRKAAKVLEE 158
ERAR Q Q E R EAE+ K R + A + A++ L E+ + R+ A+ +
Sbjct: 1536 ERAR-QVQVALETAQRSAEAELQSK-RASFAEKTAQLERSLQEEHVAVAQLREEAERRAQ 1593
Query: 159 RIHEEFKRKEEEERKRGEEQIRLQEEQRAKELYWTLKQAQLHCQA-SEKEEREWEEQLRR 217
+ E + +EE ER+ Q++ E R + + Q + QA +EK++ E E + RR
Sbjct: 1594 QQAEAERAREEAERELERWQLKANEALRLRLQAEEVAQQKSLAQAEAEKQKEEAEREARR 1653
Query: 218 SKAADEERSRRAQRARDEYRHHSLRAIQKGT 248
A+E+ R+ + A E R + +GT
Sbjct: 1654 RGKAEEQAVRQRELAEQELEKQ--RQLAEGT 1682
Score = 43.1 bits (100), Expect = 4e-04
Identities = 56/213 (26%), Positives = 92/213 (43%), Gaps = 41/213 (19%)
Query: 93 EEISEELIAERARLQAQREAEELWRQKEAEITKKFRDALANEKARIL------------- 139
E ++ + E A +AQ++AE ++EAE + ANE R+
Sbjct: 1577 EHVAVAQLREEAERRAQQQAEAERAREEAERELERWQLKANEALRLRLQAEEVAQQKSLA 1636
Query: 140 ---AEKWK--VEMEDRKAAKVLEERIHEEFKRKEEEERKR-------------GEEQIRL 181
AEK K E E R+ K E+ + + ++E E++R +E IRL
Sbjct: 1637 QAEAEKQKEEAEREARRRGKAEEQAVRQRELAEQELEKQRQLAEGTAQQRLAAEQELIRL 1696
Query: 182 -----QEEQRAKELYWTLKQAQLHCQASEKEEREWEEQLRRSKAADEERSRRAQRARDEY 236
Q EQ+ + L L + Q A+ ++ +E E +L + +A E RA +E
Sbjct: 1697 RAETEQGEQQRQLLEEELARLQREAAAATQKRQELEAELAKVRAEMEVLLASKARAEEES 1756
Query: 237 RHHSLRAIQKGTVAGLSSMFRELGQSHEQEARL 269
R S ++ Q+ + + FREL E+ ARL
Sbjct: 1757 RSTSEKSKQR--LEAEAGRFRELA---EEAARL 1784
Score = 41.6 bits (96), Expect = 0.001
Identities = 54/206 (26%), Positives = 96/206 (46%), Gaps = 16/206 (7%)
Query: 40 KERETWEALAQDEGLRPPKTKRAASDKHIQWLLGADGEVWVWIMGEGPGDKPYEEISEEL 99
+E + LA+++ R +RA +++ + L A GE K E +E L
Sbjct: 1789 EEAKRQRQLAEEDAAR----QRAEAERVLAEKLAAIGEATRLKTEAEIALKEKEAENERL 1844
Query: 100 --IAERARLQAQREAEELWRQKEAEITKKFRDALANEKARILAEKWKVEMEDRKAAKVLE 157
+AE Q +R EE Q +A+I ++ + + +K VE R+ +V E
Sbjct: 1845 RRLAEDEAFQ-RRRLEEQAAQHKADIEERLAQLRKASDSELERQKGLVEDTLRQRRQVEE 1903
Query: 158 E--RIHEEFKR----KEEEERKRGEEQIRLQEEQRAKEL--YWTLKQAQLHCQASEKEER 209
E + F++ K E E + G + ++ R+KE +Q QL + E+ R
Sbjct: 1904 EILALKASFEKAAAGKAELELELGRIRSNAEDTLRSKEQAELEAARQRQLAAE-EERRRR 1962
Query: 210 EWEEQLRRSKAADEERSRRAQRARDE 235
E EE++++S AA+EE +R+ + A +E
Sbjct: 1963 EAEERVQKSLAAEEEAARQRKAALEE 1988
Score = 40.8 bits (94), Expect = 0.002
Identities = 42/162 (25%), Positives = 76/162 (46%), Gaps = 8/162 (4%)
Query: 117 RQKEAEIT--KKFRDALANEKARILAEKWKVEMEDRKAAKVLEERIHEEFKRKE---EEE 171
RQ E EI K + A KA + E ++ + E+ E ++++ EEE
Sbjct: 1899 RQVEEEILALKASFEKAAAGKAELELELGRIRSNAEDTLRSKEQAELEAARQRQLAAEEE 1958
Query: 172 RKRGEEQIRLQEEQRAKELYWTLKQAQLHCQASEKEEREWEEQLRRSKAADEERSRRAQR 231
R+R E + R+Q+ A+E +Q + + E+ + + EE R + A++E +R+ Q
Sbjct: 1959 RRRREAEERVQKSLAAEE--EAARQRKAALEEVERLKAKVEEARRLRERAEQESARQLQL 2016
Query: 232 ARDEYRHHSLRAIQKGTVAGLSSMFRELGQSHEQEARLYHHL 273
A+ E L+A +K + +EL Q+ +QE + L
Sbjct: 2017 AQ-EAAQKRLQAEEKAHAFAVQQKEQELQQTLQQEQSVLDQL 2057
Score = 39.7 bits (91), Expect = 0.004
Identities = 32/145 (22%), Positives = 70/145 (48%), Gaps = 5/145 (3%)
Query: 93 EEISEELIAERARLQAQREAEELWRQKEA-EITKKFRDALANEKARILAEKWKVEMEDRK 151
E E+L E LQ + E + +Q++ + T+ + + +EK +L + +E E K
Sbjct: 2434 EREKEKLQQEAKLLQLKSEEMQTVQQEQLLQETQALQQSFLSEKDSLLQRERFIEQEKAK 2493
Query: 152 AAKVLEERIHEEFKRKEEEERKRGEEQIRLQEEQRAKELYWTLKQAQLHCQASEKEEREW 211
++ ++ + + + +EE++R ++Q QE QR ++ Q + + ++E
Sbjct: 2494 LEQLFQDEVAKAQQLREEQQR---QQQQMEQERQRLVASMEEARRRQHEAEEGVRRKQEE 2550
Query: 212 EEQLRRSKAADEE-RSRRAQRARDE 235
+QL + + EE + QR R++
Sbjct: 2551 LQQLEQQRRQQEELLAEENQRLREQ 2575
Score = 37.7 bits (86), Expect = 0.016
Identities = 46/172 (26%), Positives = 77/172 (44%), Gaps = 24/172 (13%)
Query: 97 EELIAERARLQAQ--------REAEELWRQKEAEITKKFRDALANEKARILAEKWK---- 144
E+L+ E LQ + E Q++A++ + F+D +A KA+ L E+ +
Sbjct: 2460 EQLLQETQALQQSFLSEKDSLLQRERFIEQEKAKLEQLFQDEVA--KAQQLREEQQRQQQ 2517
Query: 145 -VEMEDRKAAKVLEE---RIHE--EFKRKEEEERKRGEEQIRLQEEQRAKELYWTLKQAQ 198
+E E ++ +EE R HE E R+++EE ++ E+Q R QEE A+E +Q Q
Sbjct: 2518 QMEQERQRLVASMEEARRRQHEAEEGVRRKQEELQQLEQQRRQQEELLAEENQRLREQLQ 2577
Query: 199 L----HCQASEKEEREWEEQLRRSKAADEERSRRAQRARDEYRHHSLRAIQK 246
L H A E Q+ +K R A + HS +++
Sbjct: 2578 LLEEQHRAALAHSEEVTASQVAATKTLPNGRDALDGPAAEAEPEHSFDGLRR 2629
Score = 35.0 bits (79), Expect = 0.10
Identities = 35/172 (20%), Positives = 79/172 (45%), Gaps = 4/172 (2%)
Query: 97 EELIAERARLQAQREAEELWRQKEAEITKKFRDALANEKARILAEKWKVEMEDRKAAKVL 156
EEL +AR++A+ A L ++ + T++F A + ++ E ++ + ++AA++
Sbjct: 2216 EELSKLKARIEAENRALIL---RDKDNTQRFLQEEAEKMKQVAEEAARLSVAAQEAARLR 2272
Query: 157 EERIHEEFKRKEEEERKRGEEQIRLQEEQRAKELYWTLKQAQLHCQASEKEEREWEEQLR 216
+ + +++ E+ E+ +QE R K L+Q + Q + +E +EQ+
Sbjct: 2273 QLAEEDLAQQRALAEKMLKEKMQAVQEATRLKAEAELLQQQKELAQEQARRLQEDKEQMA 2332
Query: 217 RSKAADEERSRRAQRARDEYRHHSLRAIQKGTVAGLSSMFRELGQSHEQEAR 268
+ A + + +R A + R + A + ++ M R ++ E R
Sbjct: 2333 QQLAEETQGFQRTLEA-ERQRQLEMSAEAERLKLRVAEMSRAQARAEEDAQR 2383
Score = 34.7 bits (78), Expect = 0.13
Identities = 47/191 (24%), Positives = 84/191 (43%), Gaps = 22/191 (11%)
Query: 101 AERARLQAQREAEELWRQKEAEITKKFRDALANEKARILAE-----KWKVEMEDRKAAKV 155
AE+ R +A++EA + ++A + +K EK + AE K +VE E
Sbjct: 2113 AEKLRKEAEQEAARRAQAEQAALRQKQAADAEMEKHKKFAEQTLRQKAQVEQELTTLRLQ 2172
Query: 156 LEERIH------EEFKRKEEE------ERKRGEEQ---IRLQEEQRAK-ELYWTLKQAQL 199
LEE H EE +R + E +R + EE+ +R+Q E+ +K + + L
Sbjct: 2173 LEETDHQKNLLDEELQRLKAEATEAARQRSQVEEELFSVRVQMEELSKLKARIEAENRAL 2232
Query: 200 HCQASEKEEREWEEQLRRSKAADEERSRRAQRARDEYRHHSLRAIQKGTVAGLS-SMFRE 258
+ + +R +E+ + K EE +R + A++ R L L+ M +E
Sbjct: 2233 ILRDKDNTQRFLQEEAEKMKQVAEEAARLSVAAQEAARLRQLAEEDLAQQRALAEKMLKE 2292
Query: 259 LGQSHEQEARL 269
Q+ ++ RL
Sbjct: 2293 KMQAVQEATRL 2303
>gi|41322912 plectin 1 isoform 2 [Homo sapiens]
Length = 4533
Score = 55.5 bits (132), Expect = 7e-08
Identities = 63/237 (26%), Positives = 111/237 (46%), Gaps = 31/237 (13%)
Query: 17 AELSDVQKHILFYKMREEQLRRWKERETWEA-----LAQDEGLRPPKTKRAA-------S 64
A L +V++ K + E+ RR +ER E+ LAQ+ + + + A
Sbjct: 1992 AALEEVER----LKAKVEEARRLRERAEQESARQLQLAQEAAQKRLQAEEKAHAFAVQQK 2047
Query: 65 DKHIQWLLGADGEVWVWIMGEGPGDKPYEEISEELIAERARLQAQREAEELWRQ-KEAEI 123
++ +Q L + V + GE + E +EE AR+QA+REA + RQ +EAE
Sbjct: 2048 EQELQQTLQQEQSVLDQLRGEAEAARRAAEEAEE-----ARVQAEREAAQSRRQVEEAER 2102
Query: 124 TKKFRD--ALANEKARILAEKWKVEMEDRKAAKVLEERI---HEEFKRKEEEERKRGEEQ 178
K+ + A A +A+ AEK + E E A + E+ ++ E E+ K+ EQ
Sbjct: 2103 LKQSAEEQAQARAQAQAAAEKLRKEAEQEAARRAQAEQAALRQKQAADAEMEKHKKFAEQ 2162
Query: 179 IRLQEEQRAKELYWTLKQAQLHCQASEKEEREWEEQLRRSKAADEERSRRAQRARDE 235
Q+ Q +E L +L + ++ ++ +E+L+R KA E +R+ + +E
Sbjct: 2163 TLRQKAQVEQE----LTTLRLQLEETDHQKNLLDEELQRLKAEATEAARQRSQVEEE 2215
Score = 46.6 bits (109), Expect = 3e-05
Identities = 67/271 (24%), Positives = 111/271 (40%), Gaps = 36/271 (13%)
Query: 28 FYKMREEQLRRWKERETWEALAQDEGLRPPKTKRAASDKHIQWLLGADGEVWVWIMGEGP 87
+ K E LRR +E E + E AA +K Q A+ E
Sbjct: 1319 YIKFISETLRRMEEEERLAEQQRAEERERLAEVEAALEKQRQL---AEAHAQAKAQAERE 1375
Query: 88 GDKPYEEISEELI--------AERARLQAQREAEELWRQKEAEITKKFRDALANEKARIL 139
+ + + EE++ A++ + Q E ++L + EAEI K R A A E++R+
Sbjct: 1376 AKELQQRMQEEVVRREEAAVDAQQQKRSIQEELQQLRQSSEAEIQAKARQAEAAERSRLR 1435
Query: 140 AE------KWKVEMEDRKAAKVLEERIHEEFKRKEEEERKR--GEEQIRLQ-----EEQR 186
E + ++E +R+ E + +E E +KR EE RL+ E QR
Sbjct: 1436 IEEEIRVVRLQLEATERQRGGAEGELQALRARAEEAEAQKRQAQEEAERLRRQVQDESQR 1495
Query: 187 AKELYWTL-----------KQAQLHCQASEKEEREWEEQLRRSKAADEERSRRAQRARDE 235
++ L ++ Q QA E+ + EE RR + A+ ER+R+ Q A E
Sbjct: 1496 KRQAEVELASRVKAEAEAAREKQRALQALEELRLQAEEAERRLRQAEVERARQVQVAL-E 1554
Query: 236 YRHHSLRAIQKGTVAGLSSMFRELGQSHEQE 266
S A + A + +L +S ++E
Sbjct: 1555 TAQRSAEAELQSKRASFAEKTAQLERSLQEE 1585
Score = 43.5 bits (101), Expect = 3e-04
Identities = 44/151 (29%), Positives = 73/151 (48%), Gaps = 8/151 (5%)
Query: 102 ERARLQAQREAEELWRQKEAEITKKFRDALANEKARI---LAEKWKVEMEDRKAAKVLEE 158
ERAR Q Q E R EAE+ K R + A + A++ L E+ + R+ A+ +
Sbjct: 1544 ERAR-QVQVALETAQRSAEAELQSK-RASFAEKTAQLERSLQEEHVAVAQLREEAERRAQ 1601
Query: 159 RIHEEFKRKEEEERKRGEEQIRLQEEQRAKELYWTLKQAQLHCQA-SEKEEREWEEQLRR 217
+ E + +EE ER+ Q++ E R + + Q + QA +EK++ E E + RR
Sbjct: 1602 QQAEAERAREEAERELERWQLKANEALRLRLQAEEVAQQKSLAQAEAEKQKEEAEREARR 1661
Query: 218 SKAADEERSRRAQRARDEYRHHSLRAIQKGT 248
A+E+ R+ + A E R + +GT
Sbjct: 1662 RGKAEEQAVRQRELAEQELEKQ--RQLAEGT 1690
Score = 43.1 bits (100), Expect = 4e-04
Identities = 56/213 (26%), Positives = 92/213 (43%), Gaps = 41/213 (19%)
Query: 93 EEISEELIAERARLQAQREAEELWRQKEAEITKKFRDALANEKARIL------------- 139
E ++ + E A +AQ++AE ++EAE + ANE R+
Sbjct: 1585 EHVAVAQLREEAERRAQQQAEAERAREEAERELERWQLKANEALRLRLQAEEVAQQKSLA 1644
Query: 140 ---AEKWK--VEMEDRKAAKVLEERIHEEFKRKEEEERKR-------------GEEQIRL 181
AEK K E E R+ K E+ + + ++E E++R +E IRL
Sbjct: 1645 QAEAEKQKEEAEREARRRGKAEEQAVRQRELAEQELEKQRQLAEGTAQQRLAAEQELIRL 1704
Query: 182 -----QEEQRAKELYWTLKQAQLHCQASEKEEREWEEQLRRSKAADEERSRRAQRARDEY 236
Q EQ+ + L L + Q A+ ++ +E E +L + +A E RA +E
Sbjct: 1705 RAETEQGEQQRQLLEEELARLQREAAAATQKRQELEAELAKVRAEMEVLLASKARAEEES 1764
Query: 237 RHHSLRAIQKGTVAGLSSMFRELGQSHEQEARL 269
R S ++ Q+ + + FREL E+ ARL
Sbjct: 1765 RSTSEKSKQR--LEAEAGRFRELA---EEAARL 1792
Score = 41.6 bits (96), Expect = 0.001
Identities = 54/206 (26%), Positives = 96/206 (46%), Gaps = 16/206 (7%)
Query: 40 KERETWEALAQDEGLRPPKTKRAASDKHIQWLLGADGEVWVWIMGEGPGDKPYEEISEEL 99
+E + LA+++ R +RA +++ + L A GE K E +E L
Sbjct: 1797 EEAKRQRQLAEEDAAR----QRAEAERVLAEKLAAIGEATRLKTEAEIALKEKEAENERL 1852
Query: 100 --IAERARLQAQREAEELWRQKEAEITKKFRDALANEKARILAEKWKVEMEDRKAAKVLE 157
+AE Q +R EE Q +A+I ++ + + +K VE R+ +V E
Sbjct: 1853 RRLAEDEAFQ-RRRLEEQAAQHKADIEERLAQLRKASDSELERQKGLVEDTLRQRRQVEE 1911
Query: 158 E--RIHEEFKR----KEEEERKRGEEQIRLQEEQRAKEL--YWTLKQAQLHCQASEKEER 209
E + F++ K E E + G + ++ R+KE +Q QL + E+ R
Sbjct: 1912 EILALKASFEKAAAGKAELELELGRIRSNAEDTLRSKEQAELEAARQRQLAAE-EERRRR 1970
Query: 210 EWEEQLRRSKAADEERSRRAQRARDE 235
E EE++++S AA+EE +R+ + A +E
Sbjct: 1971 EAEERVQKSLAAEEEAARQRKAALEE 1996
Score = 40.8 bits (94), Expect = 0.002
Identities = 42/162 (25%), Positives = 76/162 (46%), Gaps = 8/162 (4%)
Query: 117 RQKEAEIT--KKFRDALANEKARILAEKWKVEMEDRKAAKVLEERIHEEFKRKE---EEE 171
RQ E EI K + A KA + E ++ + E+ E ++++ EEE
Sbjct: 1907 RQVEEEILALKASFEKAAAGKAELELELGRIRSNAEDTLRSKEQAELEAARQRQLAAEEE 1966
Query: 172 RKRGEEQIRLQEEQRAKELYWTLKQAQLHCQASEKEEREWEEQLRRSKAADEERSRRAQR 231
R+R E + R+Q+ A+E +Q + + E+ + + EE R + A++E +R+ Q
Sbjct: 1967 RRRREAEERVQKSLAAEE--EAARQRKAALEEVERLKAKVEEARRLRERAEQESARQLQL 2024
Query: 232 ARDEYRHHSLRAIQKGTVAGLSSMFRELGQSHEQEARLYHHL 273
A+ E L+A +K + +EL Q+ +QE + L
Sbjct: 2025 AQ-EAAQKRLQAEEKAHAFAVQQKEQELQQTLQQEQSVLDQL 2065
Score = 39.7 bits (91), Expect = 0.004
Identities = 32/145 (22%), Positives = 70/145 (48%), Gaps = 5/145 (3%)
Query: 93 EEISEELIAERARLQAQREAEELWRQKEA-EITKKFRDALANEKARILAEKWKVEMEDRK 151
E E+L E LQ + E + +Q++ + T+ + + +EK +L + +E E K
Sbjct: 2442 EREKEKLQQEAKLLQLKSEEMQTVQQEQLLQETQALQQSFLSEKDSLLQRERFIEQEKAK 2501
Query: 152 AAKVLEERIHEEFKRKEEEERKRGEEQIRLQEEQRAKELYWTLKQAQLHCQASEKEEREW 211
++ ++ + + + +EE++R ++Q QE QR ++ Q + + ++E
Sbjct: 2502 LEQLFQDEVAKAQQLREEQQR---QQQQMEQERQRLVASMEEARRRQHEAEEGVRRKQEE 2558
Query: 212 EEQLRRSKAADEE-RSRRAQRARDE 235
+QL + + EE + QR R++
Sbjct: 2559 LQQLEQQRRQQEELLAEENQRLREQ 2583
Score = 37.7 bits (86), Expect = 0.016
Identities = 46/172 (26%), Positives = 77/172 (44%), Gaps = 24/172 (13%)
Query: 97 EELIAERARLQAQ--------REAEELWRQKEAEITKKFRDALANEKARILAEKWK---- 144
E+L+ E LQ + E Q++A++ + F+D +A KA+ L E+ +
Sbjct: 2468 EQLLQETQALQQSFLSEKDSLLQRERFIEQEKAKLEQLFQDEVA--KAQQLREEQQRQQQ 2525
Query: 145 -VEMEDRKAAKVLEE---RIHE--EFKRKEEEERKRGEEQIRLQEEQRAKELYWTLKQAQ 198
+E E ++ +EE R HE E R+++EE ++ E+Q R QEE A+E +Q Q
Sbjct: 2526 QMEQERQRLVASMEEARRRQHEAEEGVRRKQEELQQLEQQRRQQEELLAEENQRLREQLQ 2585
Query: 199 L----HCQASEKEEREWEEQLRRSKAADEERSRRAQRARDEYRHHSLRAIQK 246
L H A E Q+ +K R A + HS +++
Sbjct: 2586 LLEEQHRAALAHSEEVTASQVAATKTLPNGRDALDGPAAEAEPEHSFDGLRR 2637
Score = 35.0 bits (79), Expect = 0.10
Identities = 35/172 (20%), Positives = 79/172 (45%), Gaps = 4/172 (2%)
Query: 97 EELIAERARLQAQREAEELWRQKEAEITKKFRDALANEKARILAEKWKVEMEDRKAAKVL 156
EEL +AR++A+ A L ++ + T++F A + ++ E ++ + ++AA++
Sbjct: 2224 EELSKLKARIEAENRALIL---RDKDNTQRFLQEEAEKMKQVAEEAARLSVAAQEAARLR 2280
Query: 157 EERIHEEFKRKEEEERKRGEEQIRLQEEQRAKELYWTLKQAQLHCQASEKEEREWEEQLR 216
+ + +++ E+ E+ +QE R K L+Q + Q + +E +EQ+
Sbjct: 2281 QLAEEDLAQQRALAEKMLKEKMQAVQEATRLKAEAELLQQQKELAQEQARRLQEDKEQMA 2340
Query: 217 RSKAADEERSRRAQRARDEYRHHSLRAIQKGTVAGLSSMFRELGQSHEQEAR 268
+ A + + +R A + R + A + ++ M R ++ E R
Sbjct: 2341 QQLAEETQGFQRTLEA-ERQRQLEMSAEAERLKLRVAEMSRAQARAEEDAQR 2391
Score = 34.7 bits (78), Expect = 0.13
Identities = 47/191 (24%), Positives = 84/191 (43%), Gaps = 22/191 (11%)
Query: 101 AERARLQAQREAEELWRQKEAEITKKFRDALANEKARILAE-----KWKVEMEDRKAAKV 155
AE+ R +A++EA + ++A + +K EK + AE K +VE E
Sbjct: 2121 AEKLRKEAEQEAARRAQAEQAALRQKQAADAEMEKHKKFAEQTLRQKAQVEQELTTLRLQ 2180
Query: 156 LEERIH------EEFKRKEEE------ERKRGEEQ---IRLQEEQRAK-ELYWTLKQAQL 199
LEE H EE +R + E +R + EE+ +R+Q E+ +K + + L
Sbjct: 2181 LEETDHQKNLLDEELQRLKAEATEAARQRSQVEEELFSVRVQMEELSKLKARIEAENRAL 2240
Query: 200 HCQASEKEEREWEEQLRRSKAADEERSRRAQRARDEYRHHSLRAIQKGTVAGLS-SMFRE 258
+ + +R +E+ + K EE +R + A++ R L L+ M +E
Sbjct: 2241 ILRDKDNTQRFLQEEAEKMKQVAEEAARLSVAAQEAARLRQLAEEDLAQQRALAEKMLKE 2300
Query: 259 LGQSHEQEARL 269
Q+ ++ RL
Sbjct: 2301 KMQAVQEATRL 2311
>gi|47607492 plectin 1 isoform 1 [Homo sapiens]
Length = 4574
Score = 55.5 bits (132), Expect = 7e-08
Identities = 63/237 (26%), Positives = 111/237 (46%), Gaps = 31/237 (13%)
Query: 17 AELSDVQKHILFYKMREEQLRRWKERETWEA-----LAQDEGLRPPKTKRAA-------S 64
A L +V++ K + E+ RR +ER E+ LAQ+ + + + A
Sbjct: 2033 AALEEVER----LKAKVEEARRLRERAEQESARQLQLAQEAAQKRLQAEEKAHAFAVQQK 2088
Query: 65 DKHIQWLLGADGEVWVWIMGEGPGDKPYEEISEELIAERARLQAQREAEELWRQ-KEAEI 123
++ +Q L + V + GE + E +EE AR+QA+REA + RQ +EAE
Sbjct: 2089 EQELQQTLQQEQSVLDQLRGEAEAARRAAEEAEE-----ARVQAEREAAQSRRQVEEAER 2143
Query: 124 TKKFRD--ALANEKARILAEKWKVEMEDRKAAKVLEERI---HEEFKRKEEEERKRGEEQ 178
K+ + A A +A+ AEK + E E A + E+ ++ E E+ K+ EQ
Sbjct: 2144 LKQSAEEQAQARAQAQAAAEKLRKEAEQEAARRAQAEQAALRQKQAADAEMEKHKKFAEQ 2203
Query: 179 IRLQEEQRAKELYWTLKQAQLHCQASEKEEREWEEQLRRSKAADEERSRRAQRARDE 235
Q+ Q +E L +L + ++ ++ +E+L+R KA E +R+ + +E
Sbjct: 2204 TLRQKAQVEQE----LTTLRLQLEETDHQKNLLDEELQRLKAEATEAARQRSQVEEE 2256
Score = 46.6 bits (109), Expect = 3e-05
Identities = 67/271 (24%), Positives = 111/271 (40%), Gaps = 36/271 (13%)
Query: 28 FYKMREEQLRRWKERETWEALAQDEGLRPPKTKRAASDKHIQWLLGADGEVWVWIMGEGP 87
+ K E LRR +E E + E AA +K Q A+ E
Sbjct: 1360 YIKFISETLRRMEEEERLAEQQRAEERERLAEVEAALEKQRQL---AEAHAQAKAQAERE 1416
Query: 88 GDKPYEEISEELI--------AERARLQAQREAEELWRQKEAEITKKFRDALANEKARIL 139
+ + + EE++ A++ + Q E ++L + EAEI K R A A E++R+
Sbjct: 1417 AKELQQRMQEEVVRREEAAVDAQQQKRSIQEELQQLRQSSEAEIQAKARQAEAAERSRLR 1476
Query: 140 AE------KWKVEMEDRKAAKVLEERIHEEFKRKEEEERKR--GEEQIRLQ-----EEQR 186
E + ++E +R+ E + +E E +KR EE RL+ E QR
Sbjct: 1477 IEEEIRVVRLQLEATERQRGGAEGELQALRARAEEAEAQKRQAQEEAERLRRQVQDESQR 1536
Query: 187 AKELYWTL-----------KQAQLHCQASEKEEREWEEQLRRSKAADEERSRRAQRARDE 235
++ L ++ Q QA E+ + EE RR + A+ ER+R+ Q A E
Sbjct: 1537 KRQAEVELASRVKAEAEAAREKQRALQALEELRLQAEEAERRLRQAEVERARQVQVAL-E 1595
Query: 236 YRHHSLRAIQKGTVAGLSSMFRELGQSHEQE 266
S A + A + +L +S ++E
Sbjct: 1596 TAQRSAEAELQSKRASFAEKTAQLERSLQEE 1626
Score = 43.5 bits (101), Expect = 3e-04
Identities = 44/151 (29%), Positives = 73/151 (48%), Gaps = 8/151 (5%)
Query: 102 ERARLQAQREAEELWRQKEAEITKKFRDALANEKARI---LAEKWKVEMEDRKAAKVLEE 158
ERAR Q Q E R EAE+ K R + A + A++ L E+ + R+ A+ +
Sbjct: 1585 ERAR-QVQVALETAQRSAEAELQSK-RASFAEKTAQLERSLQEEHVAVAQLREEAERRAQ 1642
Query: 159 RIHEEFKRKEEEERKRGEEQIRLQEEQRAKELYWTLKQAQLHCQA-SEKEEREWEEQLRR 217
+ E + +EE ER+ Q++ E R + + Q + QA +EK++ E E + RR
Sbjct: 1643 QQAEAERAREEAERELERWQLKANEALRLRLQAEEVAQQKSLAQAEAEKQKEEAEREARR 1702
Query: 218 SKAADEERSRRAQRARDEYRHHSLRAIQKGT 248
A+E+ R+ + A E R + +GT
Sbjct: 1703 RGKAEEQAVRQRELAEQELEKQ--RQLAEGT 1731
Score = 43.1 bits (100), Expect = 4e-04
Identities = 56/213 (26%), Positives = 92/213 (43%), Gaps = 41/213 (19%)
Query: 93 EEISEELIAERARLQAQREAEELWRQKEAEITKKFRDALANEKARIL------------- 139
E ++ + E A +AQ++AE ++EAE + ANE R+
Sbjct: 1626 EHVAVAQLREEAERRAQQQAEAERAREEAERELERWQLKANEALRLRLQAEEVAQQKSLA 1685
Query: 140 ---AEKWK--VEMEDRKAAKVLEERIHEEFKRKEEEERKR-------------GEEQIRL 181
AEK K E E R+ K E+ + + ++E E++R +E IRL
Sbjct: 1686 QAEAEKQKEEAEREARRRGKAEEQAVRQRELAEQELEKQRQLAEGTAQQRLAAEQELIRL 1745
Query: 182 -----QEEQRAKELYWTLKQAQLHCQASEKEEREWEEQLRRSKAADEERSRRAQRARDEY 236
Q EQ+ + L L + Q A+ ++ +E E +L + +A E RA +E
Sbjct: 1746 RAETEQGEQQRQLLEEELARLQREAAAATQKRQELEAELAKVRAEMEVLLASKARAEEES 1805
Query: 237 RHHSLRAIQKGTVAGLSSMFRELGQSHEQEARL 269
R S ++ Q+ + + FREL E+ ARL
Sbjct: 1806 RSTSEKSKQR--LEAEAGRFRELA---EEAARL 1833
Score = 41.6 bits (96), Expect = 0.001
Identities = 54/206 (26%), Positives = 96/206 (46%), Gaps = 16/206 (7%)
Query: 40 KERETWEALAQDEGLRPPKTKRAASDKHIQWLLGADGEVWVWIMGEGPGDKPYEEISEEL 99
+E + LA+++ R +RA +++ + L A GE K E +E L
Sbjct: 1838 EEAKRQRQLAEEDAAR----QRAEAERVLAEKLAAIGEATRLKTEAEIALKEKEAENERL 1893
Query: 100 --IAERARLQAQREAEELWRQKEAEITKKFRDALANEKARILAEKWKVEMEDRKAAKVLE 157
+AE Q +R EE Q +A+I ++ + + +K VE R+ +V E
Sbjct: 1894 RRLAEDEAFQ-RRRLEEQAAQHKADIEERLAQLRKASDSELERQKGLVEDTLRQRRQVEE 1952
Query: 158 E--RIHEEFKR----KEEEERKRGEEQIRLQEEQRAKEL--YWTLKQAQLHCQASEKEER 209
E + F++ K E E + G + ++ R+KE +Q QL + E+ R
Sbjct: 1953 EILALKASFEKAAAGKAELELELGRIRSNAEDTLRSKEQAELEAARQRQLAAE-EERRRR 2011
Query: 210 EWEEQLRRSKAADEERSRRAQRARDE 235
E EE++++S AA+EE +R+ + A +E
Sbjct: 2012 EAEERVQKSLAAEEEAARQRKAALEE 2037
Score = 40.8 bits (94), Expect = 0.002
Identities = 42/162 (25%), Positives = 76/162 (46%), Gaps = 8/162 (4%)
Query: 117 RQKEAEIT--KKFRDALANEKARILAEKWKVEMEDRKAAKVLEERIHEEFKRKE---EEE 171
RQ E EI K + A KA + E ++ + E+ E ++++ EEE
Sbjct: 1948 RQVEEEILALKASFEKAAAGKAELELELGRIRSNAEDTLRSKEQAELEAARQRQLAAEEE 2007
Query: 172 RKRGEEQIRLQEEQRAKELYWTLKQAQLHCQASEKEEREWEEQLRRSKAADEERSRRAQR 231
R+R E + R+Q+ A+E +Q + + E+ + + EE R + A++E +R+ Q
Sbjct: 2008 RRRREAEERVQKSLAAEE--EAARQRKAALEEVERLKAKVEEARRLRERAEQESARQLQL 2065
Query: 232 ARDEYRHHSLRAIQKGTVAGLSSMFRELGQSHEQEARLYHHL 273
A+ E L+A +K + +EL Q+ +QE + L
Sbjct: 2066 AQ-EAAQKRLQAEEKAHAFAVQQKEQELQQTLQQEQSVLDQL 2106
Score = 39.7 bits (91), Expect = 0.004
Identities = 32/145 (22%), Positives = 70/145 (48%), Gaps = 5/145 (3%)
Query: 93 EEISEELIAERARLQAQREAEELWRQKEA-EITKKFRDALANEKARILAEKWKVEMEDRK 151
E E+L E LQ + E + +Q++ + T+ + + +EK +L + +E E K
Sbjct: 2483 EREKEKLQQEAKLLQLKSEEMQTVQQEQLLQETQALQQSFLSEKDSLLQRERFIEQEKAK 2542
Query: 152 AAKVLEERIHEEFKRKEEEERKRGEEQIRLQEEQRAKELYWTLKQAQLHCQASEKEEREW 211
++ ++ + + + +EE++R ++Q QE QR ++ Q + + ++E
Sbjct: 2543 LEQLFQDEVAKAQQLREEQQR---QQQQMEQERQRLVASMEEARRRQHEAEEGVRRKQEE 2599
Query: 212 EEQLRRSKAADEE-RSRRAQRARDE 235
+QL + + EE + QR R++
Sbjct: 2600 LQQLEQQRRQQEELLAEENQRLREQ 2624
Score = 37.7 bits (86), Expect = 0.016
Identities = 46/172 (26%), Positives = 77/172 (44%), Gaps = 24/172 (13%)
Query: 97 EELIAERARLQAQ--------REAEELWRQKEAEITKKFRDALANEKARILAEKWK---- 144
E+L+ E LQ + E Q++A++ + F+D +A KA+ L E+ +
Sbjct: 2509 EQLLQETQALQQSFLSEKDSLLQRERFIEQEKAKLEQLFQDEVA--KAQQLREEQQRQQQ 2566
Query: 145 -VEMEDRKAAKVLEE---RIHE--EFKRKEEEERKRGEEQIRLQEEQRAKELYWTLKQAQ 198
+E E ++ +EE R HE E R+++EE ++ E+Q R QEE A+E +Q Q
Sbjct: 2567 QMEQERQRLVASMEEARRRQHEAEEGVRRKQEELQQLEQQRRQQEELLAEENQRLREQLQ 2626
Query: 199 L----HCQASEKEEREWEEQLRRSKAADEERSRRAQRARDEYRHHSLRAIQK 246
L H A E Q+ +K R A + HS +++
Sbjct: 2627 LLEEQHRAALAHSEEVTASQVAATKTLPNGRDALDGPAAEAEPEHSFDGLRR 2678
Score = 35.0 bits (79), Expect = 0.10
Identities = 35/172 (20%), Positives = 79/172 (45%), Gaps = 4/172 (2%)
Query: 97 EELIAERARLQAQREAEELWRQKEAEITKKFRDALANEKARILAEKWKVEMEDRKAAKVL 156
EEL +AR++A+ A L ++ + T++F A + ++ E ++ + ++AA++
Sbjct: 2265 EELSKLKARIEAENRALIL---RDKDNTQRFLQEEAEKMKQVAEEAARLSVAAQEAARLR 2321
Query: 157 EERIHEEFKRKEEEERKRGEEQIRLQEEQRAKELYWTLKQAQLHCQASEKEEREWEEQLR 216
+ + +++ E+ E+ +QE R K L+Q + Q + +E +EQ+
Sbjct: 2322 QLAEEDLAQQRALAEKMLKEKMQAVQEATRLKAEAELLQQQKELAQEQARRLQEDKEQMA 2381
Query: 217 RSKAADEERSRRAQRARDEYRHHSLRAIQKGTVAGLSSMFRELGQSHEQEAR 268
+ A + + +R A + R + A + ++ M R ++ E R
Sbjct: 2382 QQLAEETQGFQRTLEA-ERQRQLEMSAEAERLKLRVAEMSRAQARAEEDAQR 2432
Score = 34.7 bits (78), Expect = 0.13
Identities = 47/191 (24%), Positives = 84/191 (43%), Gaps = 22/191 (11%)
Query: 101 AERARLQAQREAEELWRQKEAEITKKFRDALANEKARILAE-----KWKVEMEDRKAAKV 155
AE+ R +A++EA + ++A + +K EK + AE K +VE E
Sbjct: 2162 AEKLRKEAEQEAARRAQAEQAALRQKQAADAEMEKHKKFAEQTLRQKAQVEQELTTLRLQ 2221
Query: 156 LEERIH------EEFKRKEEE------ERKRGEEQ---IRLQEEQRAK-ELYWTLKQAQL 199
LEE H EE +R + E +R + EE+ +R+Q E+ +K + + L
Sbjct: 2222 LEETDHQKNLLDEELQRLKAEATEAARQRSQVEEELFSVRVQMEELSKLKARIEAENRAL 2281
Query: 200 HCQASEKEEREWEEQLRRSKAADEERSRRAQRARDEYRHHSLRAIQKGTVAGLS-SMFRE 258
+ + +R +E+ + K EE +R + A++ R L L+ M +E
Sbjct: 2282 ILRDKDNTQRFLQEEAEKMKQVAEEAARLSVAAQEAARLRQLAEEDLAQQRALAEKMLKE 2341
Query: 259 LGQSHEQEARL 269
Q+ ++ RL
Sbjct: 2342 KMQAVQEATRL 2352
Database: hs.faa
Posted date: Aug 4, 2009 4:42 PM
Number of letters in database: 18,247,518
Number of sequences in database: 37,866
Lambda K H
0.317 0.132 0.399
Gapped
Lambda K H
0.267 0.0410 0.140
Matrix: BLOSUM62
Gap Penalties: Existence: 11, Extension: 1
Number of Hits to DB: 15,127,194
Number of Sequences: 37866
Number of extensions: 771665
Number of successful extensions: 14863
Number of sequences better than 10.0: 30
Number of HSP's better than 10.0 without gapping: 407
Number of HSP's successfully gapped in prelim test: 749
Number of HSP's that attempted gapping in prelim test: 5598
Number of HSP's gapped (non-prelim): 4315
length of query: 357
length of database: 18,247,518
effective HSP length: 103
effective length of query: 254
effective length of database: 14,347,320
effective search space: 3644219280
effective search space used: 3644219280
T: 11
A: 40
X1: 16 ( 7.3 bits)
X2: 38 (14.6 bits)
X3: 64 (24.7 bits)
S1: 41 (21.7 bits)
S2: 62 (28.5 bits)
Search results were obtained with NCBI BLAST and RefSeq entries.
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Guide to the Human Genome
Copyright © 2010 by Stewart Scherer. All rights reserved.