Search of human proteins with 224548925

Search of human proteins with 224548925

BLASTP 2.2.11 [Jun-05-2005]


Reference: Altschul, Stephen F., Thomas L. Madden, Alejandro A. Schaffer, 
Jinghui Zhang, Zheng Zhang, Webb Miller, and David J. Lipman (1997), 
"Gapped BLAST and PSI-BLAST: a new generation of protein database search
programs",  Nucleic Acids Res. 25:3389-3402.

Query= gi|224548925 G-protein signaling modulator 1 (AGS3-like, C.
elegans) isoform b [Homo sapiens]
         (457 letters)

Database: hs.faa 
           37,866 sequences; 18,247,518 total letters

Searching..................................................done

                                                                 Score    E
Sequences producing significant alignments:                      (bits) Value

gi|224548925 G-protein signaling modulator 1 (AGS3-like, C. eleg...   919   0.0  
gi|224548927 G-protein signaling modulator 1 (AGS3-like, C. eleg...   808   0.0  
gi|164519122 LGN protein [Homo sapiens]                               552   e-157
gi|224028289 tetratricopeptide repeat domain 28 [Homo sapiens]        200   3e-51
gi|38045928 43 kD receptor-associated protein of the synapse iso...    59   9e-09
gi|32307150 O-linked GlcNAc transferase isoform 2 [Homo sapiens]       58   2e-08
gi|32307148 O-linked GlcNAc transferase isoform 1 [Homo sapiens]       58   2e-08
gi|15619013 43 kD receptor-associated protein of the synapse iso...    55   1e-07
gi|145386551 SH3 domain and tetratricopeptide repeats 1 [Homo sa...    54   2e-07
gi|157785672 tetratricopeptide repeat domain 24 [Homo sapiens]         54   2e-07
gi|38488692 SH3 domain and tetratricopeptide repeats 2 [Homo sap...    50   6e-06
gi|187608777 NF-kappa-B inhibitor-like protein 2 [Homo sapiens]        50   6e-06
gi|13899233 tetratricopeptide repeat domain 25 [Homo sapiens]          49   9e-06
gi|22749211 transmembrane and tetratricopeptide repeat containin...    45   1e-04
gi|28558993 intraflagellar transport 88 homolog isoform 1 [Homo ...    45   2e-04
gi|28329439 intraflagellar transport 88 homolog isoform 2 [Homo ...    45   2e-04
gi|148612821 tetratricopeptide repeat domain 29 [Homo sapiens]         42   9e-04
gi|29725607 smooth muscle cell associated protein-1 isoform 2 [H...    40   0.006
gi|89179321 smooth muscle cell associated protein-1 isoform 3 [H...    39   0.008
gi|83415184 transmembrane and tetratricopeptide repeat containin...    39   0.010
gi|170784869 tetratricopeptide repeat domain 13 isoform b [Homo ...    37   0.029
gi|170784867 tetratricopeptide repeat domain 13 isoform a [Homo ...    37   0.029
gi|118402578 anaphase-promoting complex, subunit 6 [Homo sapiens]      37   0.049
gi|118402580 anaphase-promoting complex, subunit 6 [Homo sapiens]      37   0.049
gi|41871960 kinesin-like 8 isoform b [Homo sapiens]                    35   0.18 
gi|41871955 kinesin-like 8 isoform a [Homo sapiens]                    35   0.18 
gi|41871946 kinesin-like 8 isoform a [Homo sapiens]                    35   0.18 
gi|239756104 PREDICTED: tetratricopeptide repeat domain 6 [Homo ...    34   0.32 
gi|239750633 PREDICTED: tetratricopeptide repeat domain 6 [Homo ...    34   0.32 
gi|239747516 PREDICTED: hypothetical protein [Homo sapiens]            34   0.32 

>gi|224548925 G-protein signaling modulator 1 (AGS3-like, C.
           elegans) isoform b [Homo sapiens]
          Length = 457

 Score =  919 bits (2375), Expect = 0.0
 Identities = 457/457 (100%), Positives = 457/457 (100%)

Query: 1   MAGPAPPVADELPGPAARRLYSRMEASCLELALEGERLCKAGDFKTGVAFFEAAVQVGTE 60
           MAGPAPPVADELPGPAARRLYSRMEASCLELALEGERLCKAGDFKTGVAFFEAAVQVGTE
Sbjct: 1   MAGPAPPVADELPGPAARRLYSRMEASCLELALEGERLCKAGDFKTGVAFFEAAVQVGTE 60

Query: 61  DLKTLSAIYSQLGNAYFYLKEHGRALEYHKHDLLLARTIGDRMGEAKASGNLGNTLKVLG 120
           DLKTLSAIYSQLGNAYFYLKEHGRALEYHKHDLLLARTIGDRMGEAKASGNLGNTLKVLG
Sbjct: 61  DLKTLSAIYSQLGNAYFYLKEHGRALEYHKHDLLLARTIGDRMGEAKASGNLGNTLKVLG 120

Query: 121 RFDEAAVCCQRHLSIAQEQGDKVGEARALYNIGNVYHAKGKQLSWNAANATQDPGHLPPD 180
           RFDEAAVCCQRHLSIAQEQGDKVGEARALYNIGNVYHAKGKQLSWNAANATQDPGHLPPD
Sbjct: 121 RFDEAAVCCQRHLSIAQEQGDKVGEARALYNIGNVYHAKGKQLSWNAANATQDPGHLPPD 180

Query: 181 VRETLCKASEFYERNLSLVKELGDRAAQGRAYGNLGNTHYLLGNFTEATTFHKERLAIAK 240
           VRETLCKASEFYERNLSLVKELGDRAAQGRAYGNLGNTHYLLGNFTEATTFHKERLAIAK
Sbjct: 181 VRETLCKASEFYERNLSLVKELGDRAAQGRAYGNLGNTHYLLGNFTEATTFHKERLAIAK 240

Query: 241 EFGDKAAERRAYSNLGNAHVFLGRFDVAAEYYKKTLQLSRQLRDQAVEAQACYSLGNTYT 300
           EFGDKAAERRAYSNLGNAHVFLGRFDVAAEYYKKTLQLSRQLRDQAVEAQACYSLGNTYT
Sbjct: 241 EFGDKAAERRAYSNLGNAHVFLGRFDVAAEYYKKTLQLSRQLRDQAVEAQACYSLGNTYT 300

Query: 301 LLQDYERAAEYHLRHLLIAQELADRVGEGRACWSLGNAYVSMGRPAQALTFAKKHLQISQ 360
           LLQDYERAAEYHLRHLLIAQELADRVGEGRACWSLGNAYVSMGRPAQALTFAKKHLQISQ
Sbjct: 301 LLQDYERAAEYHLRHLLIAQELADRVGEGRACWSLGNAYVSMGRPAQALTFAKKHLQISQ 360

Query: 361 EIGDRHGELTARMNVAQLQLVLGRLTSPAASEKPDLAGYEAQGEFQGCGGVLLPTGTDRI 420
           EIGDRHGELTARMNVAQLQLVLGRLTSPAASEKPDLAGYEAQGEFQGCGGVLLPTGTDRI
Sbjct: 361 EIGDRHGELTARMNVAQLQLVLGRLTSPAASEKPDLAGYEAQGEFQGCGGVLLPTGTDRI 420

Query: 421 RSCGGVGSRPGQHGGGGSRQKMAPTSQFFLASGTAQA 457
           RSCGGVGSRPGQHGGGGSRQKMAPTSQFFLASGTAQA
Sbjct: 421 RSCGGVGSRPGQHGGGGSRQKMAPTSQFFLASGTAQA 457


>gi|224548927 G-protein signaling modulator 1 (AGS3-like, C.
           elegans) isoform a [Homo sapiens]
          Length = 675

 Score =  808 bits (2086), Expect = 0.0
 Identities = 403/403 (100%), Positives = 403/403 (100%)

Query: 1   MAGPAPPVADELPGPAARRLYSRMEASCLELALEGERLCKAGDFKTGVAFFEAAVQVGTE 60
           MAGPAPPVADELPGPAARRLYSRMEASCLELALEGERLCKAGDFKTGVAFFEAAVQVGTE
Sbjct: 1   MAGPAPPVADELPGPAARRLYSRMEASCLELALEGERLCKAGDFKTGVAFFEAAVQVGTE 60

Query: 61  DLKTLSAIYSQLGNAYFYLKEHGRALEYHKHDLLLARTIGDRMGEAKASGNLGNTLKVLG 120
           DLKTLSAIYSQLGNAYFYLKEHGRALEYHKHDLLLARTIGDRMGEAKASGNLGNTLKVLG
Sbjct: 61  DLKTLSAIYSQLGNAYFYLKEHGRALEYHKHDLLLARTIGDRMGEAKASGNLGNTLKVLG 120

Query: 121 RFDEAAVCCQRHLSIAQEQGDKVGEARALYNIGNVYHAKGKQLSWNAANATQDPGHLPPD 180
           RFDEAAVCCQRHLSIAQEQGDKVGEARALYNIGNVYHAKGKQLSWNAANATQDPGHLPPD
Sbjct: 121 RFDEAAVCCQRHLSIAQEQGDKVGEARALYNIGNVYHAKGKQLSWNAANATQDPGHLPPD 180

Query: 181 VRETLCKASEFYERNLSLVKELGDRAAQGRAYGNLGNTHYLLGNFTEATTFHKERLAIAK 240
           VRETLCKASEFYERNLSLVKELGDRAAQGRAYGNLGNTHYLLGNFTEATTFHKERLAIAK
Sbjct: 181 VRETLCKASEFYERNLSLVKELGDRAAQGRAYGNLGNTHYLLGNFTEATTFHKERLAIAK 240

Query: 241 EFGDKAAERRAYSNLGNAHVFLGRFDVAAEYYKKTLQLSRQLRDQAVEAQACYSLGNTYT 300
           EFGDKAAERRAYSNLGNAHVFLGRFDVAAEYYKKTLQLSRQLRDQAVEAQACYSLGNTYT
Sbjct: 241 EFGDKAAERRAYSNLGNAHVFLGRFDVAAEYYKKTLQLSRQLRDQAVEAQACYSLGNTYT 300

Query: 301 LLQDYERAAEYHLRHLLIAQELADRVGEGRACWSLGNAYVSMGRPAQALTFAKKHLQISQ 360
           LLQDYERAAEYHLRHLLIAQELADRVGEGRACWSLGNAYVSMGRPAQALTFAKKHLQISQ
Sbjct: 301 LLQDYERAAEYHLRHLLIAQELADRVGEGRACWSLGNAYVSMGRPAQALTFAKKHLQISQ 360

Query: 361 EIGDRHGELTARMNVAQLQLVLGRLTSPAASEKPDLAGYEAQG 403
           EIGDRHGELTARMNVAQLQLVLGRLTSPAASEKPDLAGYEAQG
Sbjct: 361 EIGDRHGELTARMNVAQLQLVLGRLTSPAASEKPDLAGYEAQG 403


>gi|164519122 LGN protein [Homo sapiens]
          Length = 684

 Score =  552 bits (1422), Expect = e-157
 Identities = 269/361 (74%), Positives = 311/361 (86%), Gaps = 3/361 (0%)

Query: 23  RMEASCLELALEGERLCKAGDFKTGVAFFEAAVQVGTEDLKTLSAIYSQLGNAYFYLKEH 82
           RMEASCLELALEGERLCK+GD + GV+FFEAAVQVGTEDLKTLSAIYSQLGNAYFYL ++
Sbjct: 19  RMEASCLELALEGERLCKSGDCRAGVSFFEAAVQVGTEDLKTLSAIYSQLGNAYFYLHDY 78

Query: 83  GRALEYHKHDLLLARTIGDRMGEAKASGNLGNTLKVLGRFDEAAVCCQRHLSIAQEQGDK 142
            +ALEYH HDL LARTIGD++GEAKASGNLGNTLKVLG FDEA VCCQRHL I++E  DK
Sbjct: 79  AKALEYHHHDLTLARTIGDQLGEAKASGNLGNTLKVLGNFDEAIVCCQRHLDISRELNDK 138

Query: 143 VGEARALYNIGNVYHAKGKQLSWNAANATQDPGHLPPDVRETLCKASEFYERNLSLVKEL 202
           VGEARALYN+GNVYHAKGK          QD G  P +VR+ L  A +FYE NLSLV  L
Sbjct: 139 VGEARALYNLGNVYHAKGKSFG---CPGPQDVGEFPEEVRDALQAAVDFYEENLSLVTAL 195

Query: 203 GDRAAQGRAYGNLGNTHYLLGNFTEATTFHKERLAIAKEFGDKAAERRAYSNLGNAHVFL 262
           GDRAAQGRA+GNLGNTHYLLGNF +A   H++RL IAKEFGDKAAERRAYSNLGNA++FL
Sbjct: 196 GDRAAQGRAFGNLGNTHYLLGNFRDAVIAHEQRLLIAKEFGDKAAERRAYSNLGNAYIFL 255

Query: 263 GRFDVAAEYYKKTLQLSRQLRDQAVEAQACYSLGNTYTLLQDYERAAEYHLRHLLIAQEL 322
           G F+ A+EYYKKTL L+RQL+D+AVEAQ+CYSLGNTYTLLQDYE+A +YHL+HL IAQEL
Sbjct: 256 GEFETASEYYKKTLLLARQLKDRAVEAQSCYSLGNTYTLLQDYEKAIDYHLKHLAIAQEL 315

Query: 323 ADRVGEGRACWSLGNAYVSMGRPAQALTFAKKHLQISQEIGDRHGELTARMNVAQLQLVL 382
            DR+GEGRACWSLGNAY ++G   QA+ FA+KHL+IS+E+GD+ GELTAR+N++ LQ+VL
Sbjct: 316 NDRIGEGRACWSLGNAYTALGNHDQAMHFAEKHLEISREVGDKSGELTARLNLSDLQMVL 375

Query: 383 G 383
           G
Sbjct: 376 G 376



 Score =  103 bits (257), Expect = 3e-22
 Identities = 68/240 (28%), Positives = 111/240 (46%), Gaps = 28/240 (11%)

Query: 183 ETLCKASE------FYERNLSLVKELGDRAAQGRAYGNLGNTHYLLGNFTEATTFHKERL 236
           E LCK+ +      F+E  + +  E  D       Y  LGN ++ L ++ +A  +H   L
Sbjct: 32  ERLCKSGDCRAGVSFFEAAVQVGTE--DLKTLSAIYSQLGNAYFYLHDYAKALEYHHHDL 89

Query: 237 AIAKEFGDKAAERRAYSNLGNAHVFLGRFDVAAEYYKKTLQLSRQLRDQAVEAQACYSLG 296
            +A+  GD+  E +A  NLGN    LG FD A    ++ L +SR+L D+  EA+A Y+LG
Sbjct: 90  TLARTIGDQLGEAKASGNLGNTLKVLGNFDEAIVCCQRHLDISRELNDKVGEARALYNLG 149

Query: 297 NTY--------------------TLLQDYERAAEYHLRHLLIAQELADRVGEGRACWSLG 336
           N Y                     +    + A +++  +L +   L DR  +GRA  +LG
Sbjct: 150 NVYHAKGKSFGCPGPQDVGEFPEEVRDALQAAVDFYEENLSLVTALGDRAAQGRAFGNLG 209

Query: 337 NAYVSMGRPAQALTFAKKHLQISQEIGDRHGELTARMNVAQLQLVLGRLTSPAASEKPDL 396
           N +  +G    A+   ++ L I++E GD+  E  A  N+    + LG   + +   K  L
Sbjct: 210 NTHYLLGNFRDAVIAHEQRLLIAKEFGDKAAERRAYSNLGNAYIFLGEFETASEYYKKTL 269



 Score = 77.4 bits (189), Expect = 2e-14
 Identities = 46/153 (30%), Positives = 76/153 (49%), Gaps = 12/153 (7%)

Query: 16  AARRLYSRMEASCLELALEGERLCKAGDFKTGVAFFEAAVQVGTE--DLKTLSAIYSQLG 73
           A RR YS +          G      G+F+T   +++  + +  +  D    +     LG
Sbjct: 240 AERRAYSNL----------GNAYIFLGEFETASEYYKKTLLLARQLKDRAVEAQSCYSLG 289

Query: 74  NAYFYLKEHGRALEYHKHDLLLARTIGDRMGEAKASGNLGNTLKVLGRFDEAAVCCQRHL 133
           N Y  L+++ +A++YH   L +A+ + DR+GE +A  +LGN    LG  D+A    ++HL
Sbjct: 290 NTYTLLQDYEKAIDYHLKHLAIAQELNDRIGEGRACWSLGNAYTALGNHDQAMHFAEKHL 349

Query: 134 SIAQEQGDKVGEARALYNIGNVYHAKGKQLSWN 166
            I++E GDK GE  A  N+ ++    G   S N
Sbjct: 350 EISREVGDKSGELTARLNLSDLQMVLGLSYSTN 382


>gi|224028289 tetratricopeptide repeat domain 28 [Homo sapiens]
          Length = 2481

 Score =  200 bits (508), Expect = 3e-51
 Identities = 120/372 (32%), Positives = 204/372 (54%), Gaps = 21/372 (5%)

Query: 31  LALEGERLCKAGDFKTGVAFFEAAVQVGTEDLKTLSAIYSQLGNAYFYLKEHGRALEYHK 90
           +++ G+ L  AG     V   EAA+++GT  LK   +++S L +AY+ L    ++  Y +
Sbjct: 199 VSVVGQELLTAGHHGASVVVLEAALKIGTCSLKLRGSVFSALSSAYWSLGNTEKSTGYMQ 258

Query: 91  HDLLLARTIGDRMGEAKASGNLGNTLKVLGRFDEAAVCCQRHLSIAQEQGDKVGEARALY 150
            DL +A+T+GD+ GE +A GNLG+     G + EA    +  L +A +  D+   + AL 
Sbjct: 259 QDLDVAKTLGDQTGECRAHGNLGSAFFSKGNYREALTNHRHQLVLAMKLKDREAASSALS 318

Query: 151 NIGNVYHAKGKQLSWNAANATQDPGHLPPDVRETLCKASEF------------------- 191
           ++G+VY A G     NA  + +    L    ++ L +A E                    
Sbjct: 319 SLGHVYTAIGDYP--NALASHKQCVLLAKQSKDELSEARELGNMGAVYIAMGDFENAVQC 376

Query: 192 YERNLSLVKELGDRAAQGRAYGNLGNTHYLLGNFTEATTFHKERLAIAKEFGDKAAERRA 251
           +E++L + K+LG++  + RAY NLG+ ++   NF +A ++H   L +A+E  +KA E RA
Sbjct: 377 HEQHLKIAKDLGNKREEARAYSNLGSAYHYRRNFDKAMSYHNYVLELAQELMEKAIEMRA 436

Query: 252 YSNLGNAHVFLGRFDVAAEYYKKTLQLSRQLRDQAVEAQACYSLGNTYTLLQDYERAAEY 311
           Y+ LG+A   +   + A +Y+++ L ++  L+D+A E +A  +LG  + +  DY+ A + 
Sbjct: 437 YAGLGHAARCMQDLERAKQYHEQQLGIAEDLKDRAAEGRASSNLGIIHQMKGDYDTALKL 496

Query: 312 HLRHLLIAQELADRVGEGRACWSLGNAYVSMGRPAQALTFAKKHLQISQEIGDRHGELTA 371
           H  HL IAQEL+D   +GRA  ++GNAY ++G   QA+ + ++ LQIS E+ DR  + + 
Sbjct: 497 HKTHLCIAQELSDYAAQGRAYGNMGNAYNALGMYDQAVKYHRQELQISMEVNDRASQAST 556

Query: 372 RMNVAQLQLVLG 383
             N+A     LG
Sbjct: 557 HGNLAVAYQALG 568



 Score =  199 bits (505), Expect = 6e-51
 Identities = 119/356 (33%), Positives = 193/356 (54%), Gaps = 19/356 (5%)

Query: 60  EDLKTLSAIYSQLGNAYFYLKEHGRALEYHKHDLLLARTIGDRMGEAKASGNLGNTLKVL 119
           +D +  S+  S LG+ Y  + ++  AL  HK  +LLA+   D + EA+  GN+G     +
Sbjct: 308 KDREAASSALSSLGHVYTAIGDYPNALASHKQCVLLAKQSKDELSEARELGNMGAVYIAM 367

Query: 120 GRFDEAAVCCQRHLSIAQEQGDKVGEARALYNIGNVYHAK---GKQLSWN---------- 166
           G F+ A  C ++HL IA++ G+K  EARA  N+G+ YH +    K +S++          
Sbjct: 368 GDFENAVQCHEQHLKIAKDLGNKREEARAYSNLGSAYHYRRNFDKAMSYHNYVLELAQEL 427

Query: 167 -----AANATQDPGHLPPDVRETLCKASEFYERNLSLVKELGDRAAQGRAYGNLGNTHYL 221
                   A    GH    +++ L +A +++E+ L + ++L DRAA+GRA  NLG  H +
Sbjct: 428 MEKAIEMRAYAGLGHAARCMQD-LERAKQYHEQQLGIAEDLKDRAAEGRASSNLGIIHQM 486

Query: 222 LGNFTEATTFHKERLAIAKEFGDKAAERRAYSNLGNAHVFLGRFDVAAEYYKKTLQLSRQ 281
            G++  A   HK  L IA+E  D AA+ RAY N+GNA+  LG +D A +Y+++ LQ+S +
Sbjct: 487 KGDYDTALKLHKTHLCIAQELSDYAAQGRAYGNMGNAYNALGMYDQAVKYHRQELQISME 546

Query: 282 LRDQAVEAQACYSLGNTYTLLQDYERAAEYHLRHLLIAQELADRVGEGRACWSLGNAYVS 341
           + D+A +A    +L   Y  L  ++RA +++  HL IA+EL D   E RA  +LGN + S
Sbjct: 547 VNDRASQASTHGNLAVAYQALGAHDRALQHYQNHLNIARELRDIQSEARALSNLGNFHCS 606

Query: 342 MGRPAQALTFAKKHLQISQEIGDRHGELTARMNVAQLQLVLGRLTSPAASEKPDLA 397
            G   QA  + +++L+++ ++ D  GE     N+      LG         + DLA
Sbjct: 607 RGEYVQAAPYYEQYLRLAPDLQDMEGEGKVCHNLGYAHYCLGNYQEAVKYYEQDLA 662



 Score =  175 bits (443), Expect = 9e-44
 Identities = 102/348 (29%), Positives = 185/348 (53%), Gaps = 25/348 (7%)

Query: 30  ELALEGERLCKAGDFKTGVAFFEAAVQVGTE--DLKTLSAIYSQLGNAYFYLKEHGRALE 87
           EL   G      GDF+  V   E  +++  +  + +  +  YS LG+AY Y +   +A+ 
Sbjct: 356 ELGNMGAVYIAMGDFENAVQCHEQHLKIAKDLGNKREEARAYSNLGSAYHYRRNFDKAMS 415

Query: 88  YHKHDLLLARTIGDRMGEAKASGNLGNTLKVLGRFDEAAVCCQRHLSIAQEQGDKVGEAR 147
           YH + L LA+ + ++  E +A   LG+  + +   + A    ++ L IA++  D+  E R
Sbjct: 416 YHNYVLELAQELMEKAIEMRAYAGLGHAARCMQDLERAKQYHEQQLGIAEDLKDRAAEGR 475

Query: 148 ALYNIGNVYHAKGKQLSWNAANATQDPGHLPPDVRETLCKASEFYERNLSLVKELGDRAA 207
           A  N+G ++  KG   +                       A + ++ +L + +EL D AA
Sbjct: 476 ASSNLGIIHQMKGDYDT-----------------------ALKLHKTHLCIAQELSDYAA 512

Query: 208 QGRAYGNLGNTHYLLGNFTEATTFHKERLAIAKEFGDKAAERRAYSNLGNAHVFLGRFDV 267
           QGRAYGN+GN +  LG + +A  +H++ L I+ E  D+A++   + NL  A+  LG  D 
Sbjct: 513 QGRAYGNMGNAYNALGMYDQAVKYHRQELQISMEVNDRASQASTHGNLAVAYQALGAHDR 572

Query: 268 AAEYYKKTLQLSRQLRDQAVEAQACYSLGNTYTLLQDYERAAEYHLRHLLIAQELADRVG 327
           A ++Y+  L ++R+LRD   EA+A  +LGN +    +Y +AA Y+ ++L +A +L D  G
Sbjct: 573 ALQHYQNHLNIARELRDIQSEARALSNLGNFHCSRGEYVQAAPYYEQYLRLAPDLQDMEG 632

Query: 328 EGRACWSLGNAYVSMGRPAQALTFAKKHLQISQEIGDRHGELTARMNV 375
           EG+ C +LG A+  +G   +A+ + ++ L +++++ D+  +  A  N+
Sbjct: 633 EGKVCHNLGYAHYCLGNYQEAVKYYEQDLALAKDLHDKLSQAKAYCNL 680



 Score =  174 bits (441), Expect = 1e-43
 Identities = 107/347 (30%), Positives = 179/347 (51%), Gaps = 25/347 (7%)

Query: 42  GDFKTGVAFFEAAVQVGTE--DLKTLSAIYSQLGNAYFYLKEHGRALEYHKHDLLLARTI 99
           GD+ T +   +  + +  E  D       Y  +GNAY  L  + +A++YH+ +L ++  +
Sbjct: 488 GDYDTALKLHKTHLCIAQELSDYAAQGRAYGNMGNAYNALGMYDQAVKYHRQELQISMEV 547

Query: 100 GDRMGEAKASGNLGNTLKVLGRFDEAAVCCQRHLSIAQEQGDKVGEARALYNIGNVYHAK 159
            DR  +A   GNL    + LG  D A    Q HL+IA+E  D   EARAL N+GN + ++
Sbjct: 548 NDRASQASTHGNLAVAYQALGAHDRALQHYQNHLNIARELRDIQSEARALSNLGNFHCSR 607

Query: 160 GKQLSWNAANATQDPGHLPPDVRETLCKASEFYERNLSLVKELGDRAAQGRAYGNLGNTH 219
           G+ +                       +A+ +YE+ L L  +L D   +G+   NLG  H
Sbjct: 608 GEYV-----------------------QAAPYYEQYLRLAPDLQDMEGEGKVCHNLGYAH 644

Query: 220 YLLGNFTEATTFHKERLAIAKEFGDKAAERRAYSNLGNAHVFLGRFDVAAEYYKKTLQLS 279
           Y LGN+ EA  ++++ LA+AK+  DK ++ +AY NLG A   L  F  A E  K  L L+
Sbjct: 645 YCLGNYQEAVKYYEQDLALAKDLHDKLSQAKAYCNLGLAFKALLNFSKAEECQKYLLSLA 704

Query: 280 RQLRDQAVEAQACYSLGNTYTLLQDYERAAEYHLRHLLIAQELADRVGEGRACWSLGNAY 339
           + L +   + +A  +LG+ +   +D   A +++ + L +A ++ DR  E  A  +LG AY
Sbjct: 705 QSLNNSQAKFRALGNLGDIFICKKDINGAIKFYEQQLGLAHQVKDRRLEASAYAALGTAY 764

Query: 340 VSMGRPAQALTFAKKHLQISQEIGDRHGELTARMNVAQLQLVLGRLT 386
             + +  +AL +  + L++ QE+ D  GE  A  ++A + + LG+ T
Sbjct: 765 RMIQKYDKALGYHTQELEVYQELSDLPGECRAHGHLAAVYMALGKYT 811



 Score =  154 bits (388), Expect = 2e-37
 Identities = 103/350 (29%), Positives = 181/350 (51%), Gaps = 25/350 (7%)

Query: 38   LCKAGDFKTGVAFFEAAVQVG--TEDLKTLSAIYSQLGNAYFYLKEHGRALEYHKHDLLL 95
            +CK  D    + F+E  + +    +D +  ++ Y+ LG AY  ++++ +AL YH  +L +
Sbjct: 725  ICKK-DINGAIKFYEQQLGLAHQVKDRRLEASAYAALGTAYRMIQKYDKALGYHTQELEV 783

Query: 96   ARTIGDRMGEAKASGNLGNTLKVLGRFDEAAVCCQRHLSIAQEQGDKVGEARALYNIG-- 153
             + + D  GE +A G+L      LG++  A  C +  L + Q+  D   EA+   N+G  
Sbjct: 784  YQELSDLPGECRAHGHLAAVYMALGKYTMAFKCYEEQLDLGQKLKDPSLEAQVYGNMGIT 843

Query: 154  ----NVYH----------AKGKQLSWNAA--NATQDPGHLPPDVRETLC---KASEFYER 194
                NV            A  +QLS N +  +  +  G+L  D  E L    +A ++YE+
Sbjct: 844  KMNMNVMEEAIGYFEQQLAMLQQLSGNESVLDRGRAYGNLG-DCYEALGDYEEAIKYYEQ 902

Query: 195  NLSLVKELGDRAAQGRAYGNLGNTHYLLGNFTEATTFHKERLAIAKEFGDKAAERRAYSN 254
             LS+ + L     Q +AY  LGN H  +G+  +A    ++RL +A E G+   + +AY  
Sbjct: 903  YLSVAQSLNRMQDQAKAYRGLGNGHRAMGSLQQALVCFEKRLVVAHELGEAFNKAQAYGE 962

Query: 255  LGNAHVFLGRFDVAAEYYKKTLQLSRQLRDQAVEAQACYSLGNTYTLLQDYERAAEYHLR 314
            LG+ H  LG ++ A    ++ L ++R ++D+A+E+ A   LG  Y  + +Y+ A +YH  
Sbjct: 963  LGSLHSQLGNYEQAISCLERQLNIARDMKDRALESDAACGLGGVYQQMGEYDTALQYHQL 1022

Query: 315  HLLIAQELADRVGEGRACWSLGNAYVSMGRPAQALTFAKKHLQISQEIGD 364
             L IA+E  +   +GRA  +LG  Y S+G   +A+ + ++HL I+ ++ D
Sbjct: 1023 DLQIAEETNNPTCQGRAYGNLGLTYESLGTFERAVVYQEQHLSIAAQMND 1072



 Score =  145 bits (367), Expect = 6e-35
 Identities = 99/390 (25%), Positives = 180/390 (46%), Gaps = 68/390 (17%)

Query: 39  CKAGDFKTGVAFFEAAVQVGTE--DLKTLSAIYSQLGNAYFYLKEHGRALEYHKHDLLLA 96
           C  G++     ++E  +++  +  D++    +   LG A++ L  +  A++Y++ DL LA
Sbjct: 605 CSRGEYVQAAPYYEQYLRLAPDLQDMEGEGKVCHNLGYAHYCLGNYQEAVKYYEQDLALA 664

Query: 97  RTIGDRMGEAKASGNLGNTLKVLGRFDEAAVCCQRHLSIAQEQGDKVGEARALYNIGNVY 156
           + + D++ +AKA  NLG   K L  F +A  C +  LS+AQ   +   + RAL N+G+++
Sbjct: 665 KDLHDKLSQAKAYCNLGLAFKALLNFSKAEECQKYLLSLAQSLNNSQAKFRALGNLGDIF 724

Query: 157 HAKGKQLSWNAANATQDPGHLPPDVRETLCKASEFYERNLSLVKELGDRAAQGRAYGNLG 216
             K                       + +  A +FYE+ L L  ++ DR  +  AY  LG
Sbjct: 725 ICK-----------------------KDINGAIKFYEQQLGLAHQVKDRRLEASAYAALG 761

Query: 217 NTHYLLGNFTEATTFHKERLAIAKEFGDKAAERRAYSNLGNAHVFLGRFDVAAEYYKKTL 276
             + ++  + +A  +H + L + +E  D   E RA+ +L   ++ LG++ +A + Y++ L
Sbjct: 762 TAYRMIQKYDKALGYHTQELEVYQELSDLPGECRAHGHLAAVYMALGKYTMAFKCYEEQL 821

Query: 277 QLSRQLRDQAVEAQ-------------------------------------------ACY 293
            L ++L+D ++EAQ                                           A  
Sbjct: 822 DLGQKLKDPSLEAQVYGNMGITKMNMNVMEEAIGYFEQQLAMLQQLSGNESVLDRGRAYG 881

Query: 294 SLGNTYTLLQDYERAAEYHLRHLLIAQELADRVGEGRACWSLGNAYVSMGRPAQALTFAK 353
           +LG+ Y  L DYE A +Y+ ++L +AQ L     + +A   LGN + +MG   QAL   +
Sbjct: 882 NLGDCYEALGDYEEAIKYYEQYLSVAQSLNRMQDQAKAYRGLGNGHRAMGSLQQALVCFE 941

Query: 354 KHLQISQEIGDRHGELTARMNVAQLQLVLG 383
           K L ++ E+G+   +  A   +  L   LG
Sbjct: 942 KRLVVAHELGEAFNKAQAYGELGSLHSQLG 971



 Score =  130 bits (327), Expect = 2e-30
 Identities = 85/336 (25%), Positives = 163/336 (48%), Gaps = 28/336 (8%)

Query: 42   GDFKTGVAFFEAAVQVGTE--DLKTLSAIYSQLGNAYFYLKEHGRALEYHKHDLLLARTI 99
            G +      +E  + +G +  D    + +Y  +G     +     A+ Y +  L + + +
Sbjct: 808  GKYTMAFKCYEEQLDLGQKLKDPSLEAQVYGNMGITKMNMNVMEEAIGYFEQQLAMLQQL 867

Query: 100  GDR---MGEAKASGNLGNTLKVLGRFDEAAVCCQRHLSIAQEQGDKVGEARALYNIGNVY 156
                  +   +A GNLG+  + LG ++EA    +++LS+AQ       +A+A   +GN +
Sbjct: 868  SGNESVLDRGRAYGNLGDCYEALGDYEEAIKYYEQYLSVAQSLNRMQDQAKAYRGLGNGH 927

Query: 157  HAKGKQLSWNAANATQDPGHLPPDVRETLCKASEFYERNLSLVKELGDRAAQGRAYGNLG 216
             A G                       +L +A   +E+ L +  ELG+   + +AYG LG
Sbjct: 928  RAMG-----------------------SLQQALVCFEKRLVVAHELGEAFNKAQAYGELG 964

Query: 217  NTHYLLGNFTEATTFHKERLAIAKEFGDKAAERRAYSNLGNAHVFLGRFDVAAEYYKKTL 276
            + H  LGN+ +A +  + +L IA++  D+A E  A   LG  +  +G +D A +Y++  L
Sbjct: 965  SLHSQLGNYEQAISCLERQLNIARDMKDRALESDAACGLGGVYQQMGEYDTALQYHQLDL 1024

Query: 277  QLSRQLRDQAVEAQACYSLGNTYTLLQDYERAAEYHLRHLLIAQELADRVGEGRACWSLG 336
            Q++ +  +   + +A  +LG TY  L  +ERA  Y  +HL IA ++ D   +  +  SLG
Sbjct: 1025 QIAEETNNPTCQGRAYGNLGLTYESLGTFERAVVYQEQHLSIAAQMNDLAAKTVSYSSLG 1084

Query: 337  NAYVSMGRPAQALTFAKKHLQISQEIGDRHGELTAR 372
              + ++   +QA+ + ++ L++++++G R  E   R
Sbjct: 1085 RTHHALQNYSQAVMYLQEGLRLAEQLGRREDEAKIR 1120



 Score =  124 bits (310), Expect = 2e-28
 Identities = 79/287 (27%), Positives = 137/287 (47%), Gaps = 30/287 (10%)

Query: 58   GTEDLKTLSAIYSQLGNAYFYLKEHGRALEYHKHDLLLARTIGDRMGEAKASGNLGNTLK 117
            G E +      Y  LG+ Y  L ++  A++Y++  L +A+++     +AKA   LGN  +
Sbjct: 869  GNESVLDRGRAYGNLGDCYEALGDYEEAIKYYEQYLSVAQSLNRMQDQAKAYRGLGNGHR 928

Query: 118  VLGRFDEAAVCCQRHLSIAQEQGDKVGEARALYNIGNVYHAKGKQLSWNAANATQDPGHL 177
             +G   +A VC ++ L +A E G+   +A+A   +G+++   G                 
Sbjct: 929  AMGSLQQALVCFEKRLVVAHELGEAFNKAQAYGELGSLHSQLGNYE-------------- 974

Query: 178  PPDVRETLCKASEFYERNLSLVKELGDRAAQGRAYGNLGNTHYLLGNFTEATTFHKERLA 237
                     +A    ER L++ +++ DRA +  A   LG  +  +G +  A  +H+  L 
Sbjct: 975  ---------QAISCLERQLNIARDMKDRALESDAACGLGGVYQQMGEYDTALQYHQLDLQ 1025

Query: 238  IAKEFGDKAAERRAYSNLGNAHVFLGRFDVAAEYYKKTLQLSRQLRDQAVEAQACYSLGN 297
            IA+E  +   + RAY NLG  +  LG F+ A  Y ++ L ++ Q+ D A +  +  SLG 
Sbjct: 1026 IAEETNNPTCQGRAYGNLGLTYESLGTFERAVVYQEQHLSIAAQMNDLAAKTVSYSSLGR 1085

Query: 298  TYTLLQDYERAAEYHLRHLLIAQELADRVGE-------GRACWSLGN 337
            T+  LQ+Y +A  Y    L +A++L  R  E       G + W+ GN
Sbjct: 1086 THHALQNYSQAVMYLQEGLRLAEQLGRREDEAKIRHGLGLSLWASGN 1132



 Score = 97.1 bits (240), Expect = 3e-20
 Identities = 75/298 (25%), Positives = 141/298 (47%), Gaps = 27/298 (9%)

Query: 42   GDFKTGVAFFEAAVQVGTE--DLKTLSAIYSQLGNAYFYLKEHGRALEYHKHDLLLARTI 99
            GD++  + ++E  + V      ++  +  Y  LGN +  +    +AL   +  L++A  +
Sbjct: 891  GDYEEAIKYYEQYLSVAQSLNRMQDQAKAYRGLGNGHRAMGSLQQALVCFEKRLVVAHEL 950

Query: 100  GDRMGEAKASGNLGNTLKVLGRFDEAAVCCQRHLSIAQEQGDKVGEARALYNIGNVYHAK 159
            G+   +A+A G LG+    LG +++A  C +R L+IA++  D+  E+ A   +G VY   
Sbjct: 951  GEAFNKAQAYGELGSLHSQLGNYEQAISCLERQLNIARDMKDRALESDAACGLGGVYQQM 1010

Query: 160  GK--------QLSWNAANATQDP-------GHLPPDVRE--TLCKASEFYERNLSLVKEL 202
            G+        QL    A  T +P       G+L        T  +A  + E++LS+  ++
Sbjct: 1011 GEYDTALQYHQLDLQIAEETNNPTCQGRAYGNLGLTYESLGTFERAVVYQEQHLSIAAQM 1070

Query: 203  GDRAAQGRAYGNLGNTHYLLGNFTEATTFHKERLAIAKEFGDKAAERRAYSNLGNAHVFL 262
             D AA+  +Y +LG TH+ L N+++A  + +E L +A++ G +  E +    LG +    
Sbjct: 1071 NDLAAKTVSYSSLGRTHHALQNYSQAVMYLQEGLRLAEQLGRREDEAKIRHGLGLSLWAS 1130

Query: 263  GRFDVAAEYYKKTLQLSRQLRDQAVEAQACYSLGNTYTL-LQDYERAAEYHLRHLLIA 319
            G  + A     +   L   +R +A        L   Y L L D + ++   L+ +L++
Sbjct: 1131 GNLEEAQHQLYRASALFETIRHEA-------QLSTDYKLSLFDLQTSSYQALQRVLVS 1181



 Score = 50.1 bits (118), Expect = 4e-06
 Identities = 32/105 (30%), Positives = 55/105 (52%), Gaps = 7/105 (6%)

Query: 289 AQACYSLGNTYTLLQDYERAAEYHLRHLLIAQELADRVGEGRACWSLGNAYVSMGRPAQA 348
           + A +SLGNT       E++  Y  + L +A+ L D+ GE RA  +LG+A+ S G   +A
Sbjct: 241 SSAYWSLGNT-------EKSTGYMQQDLDVAKTLGDQTGECRAHGNLGSAFFSKGNYREA 293

Query: 349 LTFAKKHLQISQEIGDRHGELTARMNVAQLQLVLGRLTSPAASEK 393
           LT  +  L ++ ++ DR    +A  ++  +   +G   +  AS K
Sbjct: 294 LTNHRHQLVLAMKLKDREAASSALSSLGHVYTAIGDYPNALASHK 338


>gi|38045928 43 kD receptor-associated protein of the synapse
           isoform 2 [Homo sapiens]
          Length = 353

 Score = 58.9 bits (141), Expect = 9e-09
 Identities = 47/180 (26%), Positives = 82/180 (45%), Gaps = 17/180 (9%)

Query: 196 LSLVKELGDRAAQGRAYGNLGNTHYLLGNFTEATTFHKERLAIAKEFGDKAAERRAYSNL 255
           +   +EL D      +Y NL  ++  L  F +  ++ K  L +           +   ++
Sbjct: 70  IDTARELEDADFLLESYLNLARSNEKLCEFHKTISYCKTCLGLPGTRAGAQLGGQVSLSM 129

Query: 256 GNAHVFLGRFDVAAEYYKKTLQLSRQLRDQAVEAQACYSLGNTYTLLQDYERAAEYHLRH 315
           GNA + L  F  A E ++K L+ +    D  +E + C SLG+ Y  ++DYE+A  +  + 
Sbjct: 130 GNAFLGLSVFQKALESFEKALRYAHNNDDAMLECRVCCSLGSFYAQVKDYEKALFFPCK- 188

Query: 316 LLIAQELADRVGEGRACWSL----------GNAYVSMGRPAQALTFAKKHLQISQEIGDR 365
              A EL +  G+G   WSL            AY  +GR   A+   ++ ++I+ + GDR
Sbjct: 189 ---AAELVNNYGKG---WSLKYRAMSQYHMAVAYRLLGRLGSAMECCEESMKIALQHGDR 242



 Score = 53.9 bits (128), Expect = 3e-07
 Identities = 48/193 (24%), Positives = 79/193 (40%), Gaps = 3/193 (1%)

Query: 198 LVKELGDRAAQGRAYGNLGNTHYLLGNFTEATTFHKERLAIAKEFGDKAAERRAYSNLGN 257
           ++++  D   + R  G L   H  +G + E   F   ++  A+E  D      +Y NL  
Sbjct: 32  VLEKSSDLMGRFRVLGCLVTAHSEMGRYKEMLKFAVVQIDTARELEDADFLLESYLNLAR 91

Query: 258 AHVFLGRFDVAAEYYKKTLQLSRQLRDQAVEAQACYSLGNTYTLLQDYERAAEYHLRHLL 317
           ++  L  F     Y K  L L        +  Q   S+GN +  L  +++A E   + L 
Sbjct: 92  SNEKLCEFHKTISYCKTCLGLPGTRAGAQLGGQVSLSMGNAFLGLSVFQKALESFEKALR 151

Query: 318 IAQELADRVGEGRACWSLGNAYVSMGRPAQALTFAKKHLQISQEIGDRHG---ELTARMN 374
            A    D + E R C SLG+ Y  +    +AL F  K  ++    G          ++ +
Sbjct: 152 YAHNNDDAMLECRVCCSLGSFYAQVKDYEKALFFPCKAAELVNNYGKGWSLKYRAMSQYH 211

Query: 375 VAQLQLVLGRLTS 387
           +A    +LGRL S
Sbjct: 212 MAVAYRLLGRLGS 224



 Score = 39.3 bits (90), Expect = 0.008
 Identities = 27/122 (22%), Positives = 54/122 (44%), Gaps = 5/122 (4%)

Query: 44  FKTGVAFFEAAVQVG--TEDLKTLSAIYSQLGNAYFYLKEHGRALEYHKHDLLLARTIGD 101
           F+  +  FE A++     +D      +   LG+ Y  +K++ +AL +      L    G 
Sbjct: 139 FQKALESFEKALRYAHNNDDAMLECRVCCSLGSFYAQVKDYEKALFFPCKAAELVNNYGK 198

Query: 102 RMG---EAKASGNLGNTLKVLGRFDEAAVCCQRHLSIAQEQGDKVGEARALYNIGNVYHA 158
                  A +  ++    ++LGR   A  CC+  + IA + GD+  +A  L    +++ +
Sbjct: 199 GWSLKYRAMSQYHMAVAYRLLGRLGSAMECCEESMKIALQHGDRPLQALCLLCFADIHRS 258

Query: 159 KG 160
           +G
Sbjct: 259 RG 260


>gi|32307150 O-linked GlcNAc transferase isoform 2 [Homo sapiens]
          Length = 1036

 Score = 57.8 bits (138), Expect = 2e-08
 Identities = 84/343 (24%), Positives = 134/343 (39%), Gaps = 67/343 (19%)

Query: 65  LSAIYSQLGNAYFYLKEHGR---ALEYHKHDLLLARTI--------------GDRMGEAK 107
           L+  YS LGN Y   KE G+   A+E+++H L L                  GD  G  +
Sbjct: 78  LAEAYSNLGNVY---KERGQLQEAIEHYRHALRLKPDFIDGYINLAAALVAAGDMEGAVQ 134

Query: 108 A--------------SGNLGNTLKVLGRFDEAAVCCQRHLSIAQEQGDKVGEARALYNIG 153
           A                +LGN LK LGR +EA  C   +L   + Q +    A A  N+G
Sbjct: 135 AYVSALQYNPDLYCVRSDLGNLLKALGRLEEAKAC---YLKAIETQPN---FAVAWSNLG 188

Query: 154 NVYHAKGKQLSWNAAN-----ATQDPGHLPPDVR-ETLCKASEFYERNL-SLVKELGDRA 206
            V++A+G+   W A +      T DP  L   +    + K +  ++R + + ++ L    
Sbjct: 189 CVFNAQGE--IWLAIHHFEKAVTLDPNFLDAYINLGNVLKEARIFDRAVAAYLRALSLSP 246

Query: 207 AQGRAYGNLGNTHYLLGNFTEATTFHKERLAIAKEFGDKAAERRAYSNLGNAHVFLGRFD 266
                +GNL   +Y  G    A   ++  + +   F D      AY NL NA    G   
Sbjct: 247 NHAVVHGNLACVYYEQGLIDLAIDTYRRAIELQPHFPD------AYCNLANALKEKGSVA 300

Query: 267 VAAEYYKKTLQLSRQLRDQAVEAQACYSLGNTYTLLQDYERAAEYHLRHLLIAQELADRV 326
            A + Y   L+L          A +  +L N      + E A   + + L +  E A   
Sbjct: 301 EAEDCYNTALRLC------PTHADSLNNLANIKREQGNIEEAVRLYRKALEVFPEFA--- 351

Query: 327 GEGRACWSLGNAYVSMGRPAQALTFAKKHLQISQEIGDRHGEL 369
               A  +L +     G+  +AL   K+ ++IS    D +  +
Sbjct: 352 ---AAHSNLASVLQQQGKLQEALMHYKEAIRISPTFADAYSNM 391



 Score = 53.1 bits (126), Expect = 5e-07
 Identities = 65/278 (23%), Positives = 106/278 (38%), Gaps = 57/278 (20%)

Query: 111 NLGNTLKVLGRFDEAAVCCQRHLSIAQEQGDKVGEARALYNIGNVYHAKG---------- 160
           NLGN LK    FD A     R LS++       G      N+  VY+ +G          
Sbjct: 220 NLGNVLKEARIFDRAVAAYLRALSLSPNHAVVHG------NLACVYYEQGLIDLAIDTYR 273

Query: 161 ---------KQLSWNAANATQDPGHLPPDVRETLCKASEFYERNLSLVKELGDRAAQGRA 211
                         N ANA ++ G        ++ +A + Y   L L     D      +
Sbjct: 274 RAIELQPHFPDAYCNLANALKEKG--------SVAEAEDCYNTALRLCPTHAD------S 319

Query: 212 YGNLGNTHYLLGNFTEATTFHKERLAIAKEFGDKAAERRAYSNLGNAHVFLGRFDVAAEY 271
             NL N     GN  EA   +++ L +  EF        A+SNL +     G+   A  +
Sbjct: 320 LNNLANIKREQGNIEEAVRLYRKALEVFPEFA------AAHSNLASVLQQQGKLQEALMH 373

Query: 272 YKKTLQLSRQLRDQAVEAQACYSLGNTYTLLQDYERAAEYHLRHLLIAQELADRVGEGRA 331
           YK+ +++S    D      A  ++GNT   +QD + A + + R + I    AD      A
Sbjct: 374 YKEAIRISPTFAD------AYSNMGNTLKEMQDVQGALQCYTRAIQINPAFAD------A 421

Query: 332 CWSLGNAYVSMGRPAQALTFAKKHLQISQEIGDRHGEL 369
             +L + +   G   +A+   +  L++  +  D +  L
Sbjct: 422 HSNLASIHKDSGNIPEAIASYRTALKLKPDFPDAYCNL 459



 Score = 30.0 bits (66), Expect = 4.6
 Identities = 38/175 (21%), Positives = 72/175 (41%), Gaps = 20/175 (11%)

Query: 42  GDFKTGVAFFEAAVQVGTEDLKTLSAIYSQLGNAYFYLKEHGRALEYHKHDLLLARTIGD 101
           G+ +  V  +  A++V  E     +A +S L +      +   AL ++K  + ++ T  D
Sbjct: 331 GNIEEAVRLYRKALEVFPE----FAAAHSNLASVLQQQGKLQEALMHYKEAIRISPTFAD 386

Query: 102 RMGEAKASGNLGNTLKVLGRFDEAAVCCQRHLSIAQEQGDKVGEARALY-NIGNVYHA-- 158
                 A  N+GNTLK +     A  C  R + I     D      +++ + GN+  A  
Sbjct: 387 ------AYSNMGNTLKEMQDVQGALQCYTRAIQINPAFADAHSNLASIHKDSGNIPEAIA 440

Query: 159 ---KGKQLSWNAANATQDPGHLPPDVRETLCKASEFYERNLSLVKELGDRAAQGR 210
                 +L  +  +A  +  H      + +C  +++ ER   LV  + D+  + R
Sbjct: 441 SYRTALKLKPDFPDAYCNLAH----CLQIVCDWTDYDERMKKLVSIVADQLEKNR 491


>gi|32307148 O-linked GlcNAc transferase isoform 1 [Homo sapiens]
          Length = 1046

 Score = 57.8 bits (138), Expect = 2e-08
 Identities = 84/343 (24%), Positives = 134/343 (39%), Gaps = 67/343 (19%)

Query: 65  LSAIYSQLGNAYFYLKEHGR---ALEYHKHDLLLARTI--------------GDRMGEAK 107
           L+  YS LGN Y   KE G+   A+E+++H L L                  GD  G  +
Sbjct: 88  LAEAYSNLGNVY---KERGQLQEAIEHYRHALRLKPDFIDGYINLAAALVAAGDMEGAVQ 144

Query: 108 A--------------SGNLGNTLKVLGRFDEAAVCCQRHLSIAQEQGDKVGEARALYNIG 153
           A                +LGN LK LGR +EA  C   +L   + Q +    A A  N+G
Sbjct: 145 AYVSALQYNPDLYCVRSDLGNLLKALGRLEEAKAC---YLKAIETQPN---FAVAWSNLG 198

Query: 154 NVYHAKGKQLSWNAAN-----ATQDPGHLPPDVR-ETLCKASEFYERNL-SLVKELGDRA 206
            V++A+G+   W A +      T DP  L   +    + K +  ++R + + ++ L    
Sbjct: 199 CVFNAQGE--IWLAIHHFEKAVTLDPNFLDAYINLGNVLKEARIFDRAVAAYLRALSLSP 256

Query: 207 AQGRAYGNLGNTHYLLGNFTEATTFHKERLAIAKEFGDKAAERRAYSNLGNAHVFLGRFD 266
                +GNL   +Y  G    A   ++  + +   F D      AY NL NA    G   
Sbjct: 257 NHAVVHGNLACVYYEQGLIDLAIDTYRRAIELQPHFPD------AYCNLANALKEKGSVA 310

Query: 267 VAAEYYKKTLQLSRQLRDQAVEAQACYSLGNTYTLLQDYERAAEYHLRHLLIAQELADRV 326
            A + Y   L+L          A +  +L N      + E A   + + L +  E A   
Sbjct: 311 EAEDCYNTALRLC------PTHADSLNNLANIKREQGNIEEAVRLYRKALEVFPEFA--- 361

Query: 327 GEGRACWSLGNAYVSMGRPAQALTFAKKHLQISQEIGDRHGEL 369
               A  +L +     G+  +AL   K+ ++IS    D +  +
Sbjct: 362 ---AAHSNLASVLQQQGKLQEALMHYKEAIRISPTFADAYSNM 401



 Score = 53.1 bits (126), Expect = 5e-07
 Identities = 65/278 (23%), Positives = 106/278 (38%), Gaps = 57/278 (20%)

Query: 111 NLGNTLKVLGRFDEAAVCCQRHLSIAQEQGDKVGEARALYNIGNVYHAKG---------- 160
           NLGN LK    FD A     R LS++       G      N+  VY+ +G          
Sbjct: 230 NLGNVLKEARIFDRAVAAYLRALSLSPNHAVVHG------NLACVYYEQGLIDLAIDTYR 283

Query: 161 ---------KQLSWNAANATQDPGHLPPDVRETLCKASEFYERNLSLVKELGDRAAQGRA 211
                         N ANA ++ G        ++ +A + Y   L L     D      +
Sbjct: 284 RAIELQPHFPDAYCNLANALKEKG--------SVAEAEDCYNTALRLCPTHAD------S 329

Query: 212 YGNLGNTHYLLGNFTEATTFHKERLAIAKEFGDKAAERRAYSNLGNAHVFLGRFDVAAEY 271
             NL N     GN  EA   +++ L +  EF        A+SNL +     G+   A  +
Sbjct: 330 LNNLANIKREQGNIEEAVRLYRKALEVFPEFA------AAHSNLASVLQQQGKLQEALMH 383

Query: 272 YKKTLQLSRQLRDQAVEAQACYSLGNTYTLLQDYERAAEYHLRHLLIAQELADRVGEGRA 331
           YK+ +++S    D      A  ++GNT   +QD + A + + R + I    AD      A
Sbjct: 384 YKEAIRISPTFAD------AYSNMGNTLKEMQDVQGALQCYTRAIQINPAFAD------A 431

Query: 332 CWSLGNAYVSMGRPAQALTFAKKHLQISQEIGDRHGEL 369
             +L + +   G   +A+   +  L++  +  D +  L
Sbjct: 432 HSNLASIHKDSGNIPEAIASYRTALKLKPDFPDAYCNL 469



 Score = 30.0 bits (66), Expect = 4.6
 Identities = 38/175 (21%), Positives = 72/175 (41%), Gaps = 20/175 (11%)

Query: 42  GDFKTGVAFFEAAVQVGTEDLKTLSAIYSQLGNAYFYLKEHGRALEYHKHDLLLARTIGD 101
           G+ +  V  +  A++V  E     +A +S L +      +   AL ++K  + ++ T  D
Sbjct: 341 GNIEEAVRLYRKALEVFPE----FAAAHSNLASVLQQQGKLQEALMHYKEAIRISPTFAD 396

Query: 102 RMGEAKASGNLGNTLKVLGRFDEAAVCCQRHLSIAQEQGDKVGEARALY-NIGNVYHA-- 158
                 A  N+GNTLK +     A  C  R + I     D      +++ + GN+  A  
Sbjct: 397 ------AYSNMGNTLKEMQDVQGALQCYTRAIQINPAFADAHSNLASIHKDSGNIPEAIA 450

Query: 159 ---KGKQLSWNAANATQDPGHLPPDVRETLCKASEFYERNLSLVKELGDRAAQGR 210
                 +L  +  +A  +  H      + +C  +++ ER   LV  + D+  + R
Sbjct: 451 SYRTALKLKPDFPDAYCNLAH----CLQIVCDWTDYDERMKKLVSIVADQLEKNR 501


>gi|15619013 43 kD receptor-associated protein of the synapse
           isoform 1 [Homo sapiens]
          Length = 412

 Score = 55.5 bits (132), Expect = 1e-07
 Identities = 55/225 (24%), Positives = 90/225 (40%), Gaps = 43/225 (19%)

Query: 196 LSLVKELGDRAAQGRAYGNLGNTHYLLGNFTEATTFHKERLAIAKEFGDKAAERRAYSNL 255
           +   +EL D      +Y NL  ++  L  F +  ++ K  L +           +   ++
Sbjct: 70  IDTARELEDADFLLESYLNLARSNEKLCEFHKTISYCKTCLGLPGTRAGAQLGGQVSLSM 129

Query: 256 GNAHVFLGRFDVAAEYYKKTLQLSRQLRDQAVEAQACYSLGNTYTLLQDYERAAEYHLR- 314
           GNA + L  F  A E ++K L+ +    D  +E + C SLG+ Y  ++DYE+A  +  + 
Sbjct: 130 GNAFLGLSVFQKALESFEKALRYAHNNDDAMLECRVCCSLGSFYAQVKDYEKALFFPCKA 189

Query: 315 ---------------------HLLIAQELADRVGEGRACW--SLGNAYVSMGRPAQALT- 350
                                H+ +A  L  R+G    C   S+  A     RP QAL  
Sbjct: 190 AELVNNYGKGWSLKYRAMSQYHMAVAYRLLGRLGSAMECCEESMKIALQHGDRPLQALCL 249

Query: 351 --FAKKH----------------LQISQEIGDRHGELTARMNVAQ 377
             FA  H                + I  EIG+R G++ A + VA+
Sbjct: 250 LCFADIHRSRGDLETAFPRYDSAMSIMTEIGNRLGQVQALLGVAK 294



 Score = 53.9 bits (128), Expect = 3e-07
 Identities = 48/193 (24%), Positives = 79/193 (40%), Gaps = 3/193 (1%)

Query: 198 LVKELGDRAAQGRAYGNLGNTHYLLGNFTEATTFHKERLAIAKEFGDKAAERRAYSNLGN 257
           ++++  D   + R  G L   H  +G + E   F   ++  A+E  D      +Y NL  
Sbjct: 32  VLEKSSDLMGRFRVLGCLVTAHSEMGRYKEMLKFAVVQIDTARELEDADFLLESYLNLAR 91

Query: 258 AHVFLGRFDVAAEYYKKTLQLSRQLRDQAVEAQACYSLGNTYTLLQDYERAAEYHLRHLL 317
           ++  L  F     Y K  L L        +  Q   S+GN +  L  +++A E   + L 
Sbjct: 92  SNEKLCEFHKTISYCKTCLGLPGTRAGAQLGGQVSLSMGNAFLGLSVFQKALESFEKALR 151

Query: 318 IAQELADRVGEGRACWSLGNAYVSMGRPAQALTFAKKHLQISQEIGDRHG---ELTARMN 374
            A    D + E R C SLG+ Y  +    +AL F  K  ++    G          ++ +
Sbjct: 152 YAHNNDDAMLECRVCCSLGSFYAQVKDYEKALFFPCKAAELVNNYGKGWSLKYRAMSQYH 211

Query: 375 VAQLQLVLGRLTS 387
           +A    +LGRL S
Sbjct: 212 MAVAYRLLGRLGS 224



 Score = 45.1 bits (105), Expect = 1e-04
 Identities = 38/186 (20%), Positives = 88/186 (47%), Gaps = 3/186 (1%)

Query: 187 KASEFYERNLSLVKELGDRAAQGRAYGNLGNTHYLLGNFTEATTFHKERLAIAKEFGDK- 245
           KA E +E+ L       D   + R   +LG+ +  + ++ +A  F  +   +   +G   
Sbjct: 141 KALESFEKALRYAHNNDDAMLECRVCCSLGSFYAQVKDYEKALFFPCKAAELVNNYGKGW 200

Query: 246 AAERRAYS--NLGNAHVFLGRFDVAAEYYKKTLQLSRQLRDQAVEAQACYSLGNTYTLLQ 303
           + + RA S  ++  A+  LGR   A E  +++++++ Q  D+ ++A       + +    
Sbjct: 201 SLKYRAMSQYHMAVAYRLLGRLGSAMECCEESMKIALQHGDRPLQALCLLCFADIHRSRG 260

Query: 304 DYERAAEYHLRHLLIAQELADRVGEGRACWSLGNAYVSMGRPAQALTFAKKHLQISQEIG 363
           D E A   +   + I  E+ +R+G+ +A   +   +V+     +AL   ++   +++E+G
Sbjct: 261 DLETAFPRYDSAMSIMTEIGNRLGQVQALLGVAKCWVARKALDKALDAIERAQDLAEEVG 320

Query: 364 DRHGEL 369
           ++  +L
Sbjct: 321 NKLSQL 326



 Score = 42.7 bits (99), Expect = 7e-04
 Identities = 56/290 (19%), Positives = 108/290 (37%), Gaps = 54/290 (18%)

Query: 44  FKTGVAFFEAAVQVG--TEDLKTLSAIYSQLGNAYFYLKEHGRALEYHKHDLLLARTIGD 101
           F+  +  FE A++     +D      +   LG+ Y  +K++ +AL +      L    G 
Sbjct: 139 FQKALESFEKALRYAHNNDDAMLECRVCCSLGSFYAQVKDYEKALFFPCKAAELVNNYGK 198

Query: 102 RMG---EAKASGNLGNTLKVLGRFDEAAVCCQRHLSIAQEQGDKVGEARALYNIGNVYHA 158
                  A +  ++    ++LGR   A  CC+  + IA + GD+  +A  L    +++ +
Sbjct: 199 GWSLKYRAMSQYHMAVAYRLLGRLGSAMECCEESMKIALQHGDRPLQALCLLCFADIHRS 258

Query: 159 KGKQLSWNAANATQDPGHLPPDVRETLCKASEFYERNLSLVKELGDRAAQGRAYGNLGNT 218
           +G                        L  A   Y+  +S++ E+G+R  Q +A   +   
Sbjct: 259 RG-----------------------DLETAFPRYDSAMSIMTEIGNRLGQVQALLGVAKC 295

Query: 219 HYLLGNFTEATTFHKERLAIAKEFGDKAAERRAYSNLGNAHVFLGRFDVAAEYYKKTLQL 278
                   +A    +    +A+E G+K ++ + +                +E   ++  L
Sbjct: 296 WVARKALDKALDAIERAQDLAEEVGNKLSQLKLH--------------CLSESIYRSKGL 341

Query: 279 SRQLRDQAVEAQACY------------SLGNTYTLLQDYERAAEYHLRHL 316
            R+LR   V    C             S+G   + LQ    +  +HLR L
Sbjct: 342 QRELRAHVVRFHECVEETELYCGLCGESIGEKNSRLQALPCSHIFHLRCL 391


>gi|145386551 SH3 domain and tetratricopeptide repeats 1 [Homo
            sapiens]
          Length = 1336

 Score = 54.3 bits (129), Expect = 2e-07
 Identities = 76/293 (25%), Positives = 115/293 (39%), Gaps = 31/293 (10%)

Query: 17   ARRLYSRME-ASC----LELALEGERLC-KAGDFKTGVAFFEAAVQVGTEDLKTLSAIYS 70
            A RL+SR+    C      + L+   LC + G  + G  ++E A+ V  E     S + +
Sbjct: 929  AVRLFSRLPLGECGRDFTHVLLQLGHLCTRQGPAQQGKGYYEWALLVAVEMGHVESQLRA 988

Query: 71   QLGNAYFY---LKEHGRALEYHKHDLLLARTIGDRMGEAKASGNLGNTLKVLGR---FDE 124
                 +FY   +    + + YH+  L LA  + D++ E +    +      LG    +  
Sbjct: 989  VQRLCHFYSAVMPSEAQCVIYHELQLSLACKVADKVLEGQLLETISQLYLSLGTERAYKS 1048

Query: 125  AAVCCQRHLSIAQEQGDKVGEARALYNIGNVYHAKGK--------QLSWNAANATQDP-- 174
            A    +R L I  +   K  EA A    G +Y+   +        Q++ N A  T DP  
Sbjct: 1049 ALDYTKRSLGIFIDLQKKEKEAHAWLQAGKIYYILRQSELVDLYIQVAQNVALYTGDPNL 1108

Query: 175  --------GHLPPDVRETLCKASEFY-ERNLSLVKELGDRAAQGRAYGNLGNTHYLLGNF 225
                    G +  D      KA  FY +R L L    G+R A+ R    L      L   
Sbjct: 1109 GLELFEAAGDIFFDGAWEREKAVSFYRDRALPLAVTTGNRKAELRLCNKLVALLATLEEP 1168

Query: 226  TEATTFHKERLAIAKEFGDKAAERRAYSNLGNAHVFLGRFDVAAEYYKKTLQL 278
             E   F    LA++   GD+  ER AY  L      LG  ++A  +Y K L L
Sbjct: 1169 QEGLEFAHMALALSITLGDRLNERVAYHRLAALQHRLGHGELAEHFYLKALSL 1221



 Score = 53.1 bits (126), Expect = 5e-07
 Identities = 77/334 (23%), Positives = 128/334 (38%), Gaps = 66/334 (19%)

Query: 116  LKVLGRFDEAAVCCQRHLSIAQEQGDKVGEARALYNIGNV-YHAKGKQLSWN-AANATQD 173
            LK  GR  +AA    R L +A++ G +  +A  L N G +  HA   +L+ +    A + 
Sbjct: 873  LKRTGRTRQAAESYYRALRVARDLGQQRNQAVGLANFGALCLHAGASRLAQHYLLEAVRL 932

Query: 174  PGHLP-----PDVRETLCKASE-------------FYERNLSLVKELGDRAAQGRAYGNL 215
               LP      D    L +                +YE  L +  E+G   +Q RA   L
Sbjct: 933  FSRLPLGECGRDFTHVLLQLGHLCTRQGPAQQGKGYYEWALLVAVEMGHVESQLRAVQRL 992

Query: 216  GNTHY-LLGNFTEATTFHKERLAIAKEFGDKAAERRAYSNLGNAHVFLGR---FDVAAEY 271
             + +  ++ +  +   +H+ +L++A +  DK  E +    +   ++ LG    +  A +Y
Sbjct: 993  CHFYSAVMPSEAQCVIYHELQLSLACKVADKVLEGQLLETISQLYLSLGTERAYKSALDY 1052

Query: 272  YKKTLQLSRQLRDQAVEAQACYSLGNTYTLLQD--------------------------- 304
             K++L +   L+ +  EA A    G  Y +L+                            
Sbjct: 1053 TKRSLGIFIDLQKKEKEAHAWLQAGKIYYILRQSELVDLYIQVAQNVALYTGDPNLGLEL 1112

Query: 305  YERAAE---------------YHLRHLLIAQELADRVGEGRACWSLGNAYVSMGRPAQAL 349
            +E A +               Y  R L +A    +R  E R C  L     ++  P + L
Sbjct: 1113 FEAAGDIFFDGAWEREKAVSFYRDRALPLAVTTGNRKAELRLCNKLVALLATLEEPQEGL 1172

Query: 350  TFAKKHLQISQEIGDRHGELTARMNVAQLQLVLG 383
             FA   L +S  +GDR  E  A   +A LQ  LG
Sbjct: 1173 EFAHMALALSITLGDRLNERVAYHRLAALQHRLG 1206


>gi|157785672 tetratricopeptide repeat domain 24 [Homo sapiens]
          Length = 302

 Score = 54.3 bits (129), Expect = 2e-07
 Identities = 34/110 (30%), Positives = 51/110 (46%)

Query: 219 HYLLGNFTEATTFHKERLAIAKEFGDKAAERRAYSNLGNAHVFLGRFDVAAEYYKKTLQL 278
           H  LGN+ EA  FH++   +    G +  + R++ +L  A   LG    A + Y   LQ 
Sbjct: 3   HNALGNYQEAREFHQKAADLHGSVGQRWEQGRSFGSLAFALSQLGDHKAARDNYLHALQA 62

Query: 279 SRQLRDQAVEAQACYSLGNTYTLLQDYERAAEYHLRHLLIAQELADRVGE 328
           +R   D   + QAC  LG     L  Y++A +Y+   L   Q+  D V E
Sbjct: 63  ARDSGDMKGQWQACEGLGAAAARLGQYDQALKYYKEALAQCQKEPDSVRE 112



 Score = 53.1 bits (126), Expect = 5e-07
 Identities = 32/102 (31%), Positives = 52/102 (50%)

Query: 187 KASEFYERNLSLVKELGDRAAQGRAYGNLGNTHYLLGNFTEATTFHKERLAIAKEFGDKA 246
           +A EF+++   L   +G R  QGR++G+L      LG+   A   +   L  A++ GD  
Sbjct: 11  EAREFHQKAADLHGSVGQRWEQGRSFGSLAFALSQLGDHKAARDNYLHALQAARDSGDMK 70

Query: 247 AERRAYSNLGNAHVFLGRFDVAAEYYKKTLQLSRQLRDQAVE 288
            + +A   LG A   LG++D A +YYK+ L   ++  D   E
Sbjct: 71  GQWQACEGLGAAAARLGQYDQALKYYKEALAQCQKEPDSVRE 112



 Score = 51.6 bits (122), Expect = 1e-06
 Identities = 42/153 (27%), Positives = 71/153 (46%), Gaps = 15/153 (9%)

Query: 258 AHVFLGRFDVAAEYYKKTLQLSRQLRDQAVEAQACYSLGNTYTLLQDYERAAEYHLRHLL 317
           AH  LG +  A E+++K   L   +  +  + ++  SL    + L D++ A + +L  L 
Sbjct: 2   AHNALGNYQEAREFHQKAADLHGSVGQRWEQGRSFGSLAFALSQLGDHKAARDNYLHALQ 61

Query: 318 IAQELADRVGEGRACWSLGNAYVSMGRPAQALTFAKKHLQISQEIGDRHGEL-------T 370
            A++  D  G+ +AC  LG A   +G+  QAL + K+ L   Q+  D   E        T
Sbjct: 62  AARDSGDMKGQWQACEGLGAAAARLGQYDQALKYYKEALAQCQKEPDSVRERLVAKLADT 121

Query: 371 ARMNVAQLQLVL--------GRLTSPAASEKPD 395
            R  +AQ+ LV         GRL +P  + + +
Sbjct: 122 VRTRLAQVGLVQTHTLTSAPGRLQAPGGASQAE 154



 Score = 38.1 bits (87), Expect = 0.017
 Identities = 24/77 (31%), Positives = 37/77 (48%)

Query: 69  YSQLGNAYFYLKEHGRALEYHKHDLLLARTIGDRMGEAKASGNLGNTLKVLGRFDEAAVC 128
           +  L  A   L +H  A + + H L  AR  GD  G+ +A   LG     LG++D+A   
Sbjct: 36  FGSLAFALSQLGDHKAARDNYLHALQAARDSGDMKGQWQACEGLGAAAARLGQYDQALKY 95

Query: 129 CQRHLSIAQEQGDKVGE 145
            +  L+  Q++ D V E
Sbjct: 96  YKEALAQCQKEPDSVRE 112



 Score = 32.3 bits (72), Expect = 0.92
 Identities = 19/62 (30%), Positives = 29/62 (46%)

Query: 188 ASEFYERNLSLVKELGDRAAQGRAYGNLGNTHYLLGNFTEATTFHKERLAIAKEFGDKAA 247
           A + Y   L   ++ GD   Q +A   LG     LG + +A  ++KE LA  ++  D   
Sbjct: 52  ARDNYLHALQAARDSGDMKGQWQACEGLGAAAARLGQYDQALKYYKEALAQCQKEPDSVR 111

Query: 248 ER 249
           ER
Sbjct: 112 ER 113



 Score = 31.2 bits (69), Expect = 2.0
 Identities = 21/79 (26%), Positives = 36/79 (45%)

Query: 75  AYFYLKEHGRALEYHKHDLLLARTIGDRMGEAKASGNLGNTLKVLGRFDEAAVCCQRHLS 134
           A+  L  +  A E+H+    L  ++G R  + ++ G+L   L  LG    A       L 
Sbjct: 2   AHNALGNYQEAREFHQKAADLHGSVGQRWEQGRSFGSLAFALSQLGDHKAARDNYLHALQ 61

Query: 135 IAQEQGDKVGEARALYNIG 153
            A++ GD  G+ +A   +G
Sbjct: 62  AARDSGDMKGQWQACEGLG 80


>gi|38488692 SH3 domain and tetratricopeptide repeats 2 [Homo sapiens]
          Length = 1288

 Score = 49.7 bits (117), Expect = 6e-06
 Identities = 80/349 (22%), Positives = 132/349 (37%), Gaps = 45/349 (12%)

Query: 17   ARRLYSRMEASCLELALE--------GERLCKAGDFKTGVAFFEAAVQVGTEDLKTLSAI 68
            A RLY  ++AS  E  +E         + L        G+  +E A+  G       S +
Sbjct: 902  AVRLYCELQAS-KETDMELVQVFLWLAQVLVSGHQLTHGLLCYEMALLFGLRHRHLKSQL 960

Query: 69   YSQLGNAYFYLKEHGR---ALEYHKHDLLLARTIGDRMGEAKASGNLG------NTLKVL 119
             +     +FY          + YH+H L LA+ + DR  E +   +LG      NT + L
Sbjct: 961  QATKSLCHFYSSVSPNPEACITYHEHWLALAQQLRDREMEGRLLESLGQLYRNLNTARSL 1020

Query: 120  GRFDEAAVCCQRHLSIAQEQGDKVGEARALYNIGNVYHAKGK----QLSWNAANAT---- 171
             R   +  C +  L I  + G+    A A    G +++   +    +L   AA  T    
Sbjct: 1021 RR---SLTCIKESLRIFIDLGETDKAAEAWLGAGRLHYLMQEDELVELCLQAAIQTALKS 1077

Query: 172  ----------QDPGHLPPDVRETLCKASEFYERN-LSLVKELGDRAAQGRAYGNLGNTHY 220
                      ++ G +  +       A E+Y    + L + L     + R +  L     
Sbjct: 1078 EEPLLALKLYEEAGDVFFNGTRHRHHAVEYYRAGAVPLARRLKAVRTELRIFNKLTELQI 1137

Query: 221  LLGNFTEATTFHKERLAIAKEFGDKAAERRAYSNLGNAHVFLGRFDVAAEYYKKTLQLS- 279
             L  + +A  F      ++   GD+  E  A+  L   +  L  +++A + Y KTL L  
Sbjct: 1138 SLEGYEKALEFATLAARLSTVTGDQRQELVAFHRLATVYYSLHMYEMAEDCYLKTLSLCP 1197

Query: 280  ---RQLRDQAVEAQACYSLGN-TYTLLQDYERAAEYHLRHLLIAQELAD 324
               +  ++    A+  Y LG  T+  L+D   A EY L  L  A  L D
Sbjct: 1198 PWLQSPKEALYYAKVYYRLGRLTFCQLKDAHDATEYFLLALAAAVLLGD 1246



 Score = 47.0 bits (110), Expect = 4e-05
 Identities = 53/210 (25%), Positives = 92/210 (43%), Gaps = 20/210 (9%)

Query: 187  KASEFYERNLSLVKELGDRAAQGRAYGNLGNTHYLLGNFTEATTFHKER---LAIAKEFG 243
            +A++ Y R L+  +E+GD   Q  A  NLG  H  L ++ +    H  R   L   + + 
Sbjct: 854  RAAKSYLRALNRAQEVGDVHNQAVAMANLG--HLSLKSWAQ----HPARNYLLQAVRLYC 907

Query: 244  DKAAERRAYSNLGNAHVFLGRFDVAAEY-------YKKTLQLSRQLRDQAVEAQACYSLG 296
            +  A +     L    ++L +  V+          Y+  L    + R    + QA  SL 
Sbjct: 908  ELQASKETDMELVQVFLWLAQVLVSGHQLTHGLLCYEMALLFGLRHRHLKSQLQATKSLC 967

Query: 297  NTYTLLQ-DYERAAEYHLRHLLIAQELADRVGEGRACWSLGNAYVSMGRP---AQALTFA 352
            + Y+ +  + E    YH   L +AQ+L DR  EGR   SLG  Y ++       ++LT  
Sbjct: 968  HFYSSVSPNPEACITYHEHWLALAQQLRDREMEGRLLESLGQLYRNLNTARSLRRSLTCI 1027

Query: 353  KKHLQISQEIGDRHGELTARMNVAQLQLVL 382
            K+ L+I  ++G+      A +   +L  ++
Sbjct: 1028 KESLRIFIDLGETDKAAEAWLGAGRLHYLM 1057



 Score = 43.1 bits (100), Expect = 5e-04
 Identities = 84/364 (23%), Positives = 138/364 (37%), Gaps = 59/364 (16%)

Query: 50  FFEAAVQV---GTEDLKTLSAIYSQLGNAYFYLKEHGRALEYHKHDLLLART------IG 100
           +FE A+ +     EDL  ++ +Y  L  A  YLK+  R    HK   LL +       + 
Sbjct: 550 YFEEAIHILNGAFEDLSLVATLYINL--AAIYLKQRLR----HKGSALLEKAGALLACLP 603

Query: 101 DRMGEAKASGNLGNTLKVLGRFDEAAVCCQRHLSIAQEQGDKVGEARALYNIGNVYHAKG 160
           DR   AK               D  A   ++ + +    G    EARA +    +  + G
Sbjct: 604 DRESSAKHE------------LDVVAYVLRQGIVV----GSSPLEARACFLAIRLLLSLG 647

Query: 161 K--QLSWNAANATQDPGHLPPDVRETLCKASEFYERN------LSLVKELGDRAAQGRAY 212
           +  ++   A       GH PP         S  Y++       ++ V++ G ++AQG + 
Sbjct: 648 RHEEVLPFAERLQLLSGH-PPASEAVASVLSFLYDKKYLPHLAVASVQQHGIQSAQGMSL 706

Query: 213 GNLGNTHYLLGNFTEATTFH---------------KERLAIAKEFGDKAAERRAYSNLGN 257
             +   H +L N T+   F                ++ LA  +E  D++ +R     L  
Sbjct: 707 P-IWQVHLVLQNTTKLLGFPSPGWGEVSALACPMLRQALAACEELADRSTQRALCLILSK 765

Query: 258 AHVFLGRFDVAAEYYKKTLQLSRQLRDQ-AVEAQACYSLGNTYTLLQDYERAAEYHLRHL 316
            ++     D A  Y  + L L + L +Q + E+  C  L   Y L    ++A +     L
Sbjct: 766 VYLEHRSPDGAIHYLSQALVLGQLLGEQESFESSLC--LAWAYLLASQAKKALDVLEPLL 823

Query: 317 LIAQELADRVGEGRACWSLGNAYVSMGRPAQALTFAKKHLQISQEIGDRHGELTARMNVA 376
              +E       G     LG A    GR  +A     + L  +QE+GD H +  A  N+ 
Sbjct: 824 CSLKETESLTQRGVIYNLLGLALQGEGRVNRAAKSYLRALNRAQEVGDVHNQAVAMANLG 883

Query: 377 QLQL 380
            L L
Sbjct: 884 HLSL 887


>gi|187608777 NF-kappa-B inhibitor-like protein 2 [Homo sapiens]
          Length = 1378

 Score = 49.7 bits (117), Expect = 6e-06
 Identities = 83/356 (23%), Positives = 138/356 (38%), Gaps = 70/356 (19%)

Query: 66  SAIYSQLGNAYFYLKEHGR---ALEYHKHDLLLARTIGDRMGEAKASGNLGNTLKVLGRF 122
           +A+  QLG     L  HGR   ALE H  +L L     D +G A A   +G  L  +  +
Sbjct: 27  AALCHQLGEL---LAGHGRYAEALEQHWQELQLRERADDPLGCAVAHRKIGERLAEMEDY 83

Query: 123 DEAAVCCQRHLSIAQEQGDKVGEARALYNIGNVY-----HAKGKQLSWNAANATQDPGHL 177
             A     ++L +A    +     RA   IG  +     H +                  
Sbjct: 84  PAALQHQHQYLELAHSLRNHTELQRAWATIGRTHLDIYDHCQS----------------- 126

Query: 178 PPDVRETLCKASEFYERNLSLV-KELGDRAAQG-------RAYGNLGNTHYLLGNFTEAT 229
               R+ L +A   +E++L++V +EL    AQG       R Y NLG T   L       
Sbjct: 127 ----RDALLQAQAAFEKSLAIVDEELEGTLAQGELNEMRTRLYLNLGLTFESLQQTALCN 182

Query: 230 TFHKERLAIAKEFGDKAAERRAYSNLGNAHVFLGRFDVAAEYYKKTLQLSRQLRDQAVEA 289
            + ++ + +A++        RA  NLG  H   G+   A    +   + +  +R + +E+
Sbjct: 183 DYFRKSIFLAEQNHLYEDLFRARYNLGTIHWRAGQHSQAMRCLEGARECAHTMRKRFMES 242

Query: 290 QACYSLGNTYTLLQDY-------------------ERAAE-YHLRHLLIAQELADRV--G 327
           + C  +      L D+                   +RAA   +L+H+L    L  ++   
Sbjct: 243 ECCVVIAQVLQDLGDFLAAKRALKKAYRLGSQKPVQRAAICQNLQHVLAVVRLQQQLEEA 302

Query: 328 EGR-------ACWSLGNAYVSMGRPAQALTFAKKHLQISQEIGDRHGELTARMNVA 376
           EGR        C  LG+ +   G   +A    +K L+ + E+ DR G   A ++V+
Sbjct: 303 EGRDPQGAMVICEQLGDLFSKAGDFPRAAEAYQKQLRFA-ELLDRPGAERAIIHVS 357



 Score = 35.0 bits (79), Expect = 0.14
 Identities = 26/106 (24%), Positives = 46/106 (43%)

Query: 237 AIAKEFGDKAAERRAYSNLGNAHVFLGRFDVAAEYYKKTLQLSRQLRDQAVEAQACYSLG 296
           A A+  G +  E      LG      GR+  A E + + LQL  +  D    A A   +G
Sbjct: 15  AKAQRAGQRREEAALCHQLGELLAGHGRYAEALEQHWQELQLRERADDPLGCAVAHRKIG 74

Query: 297 NTYTLLQDYERAAEYHLRHLLIAQELADRVGEGRACWSLGNAYVSM 342
                ++DY  A ++  ++L +A  L +     RA  ++G  ++ +
Sbjct: 75  ERLAEMEDYPAALQHQHQYLELAHSLRNHTELQRAWATIGRTHLDI 120


>gi|13899233 tetratricopeptide repeat domain 25 [Homo sapiens]
          Length = 672

 Score = 48.9 bits (115), Expect = 9e-06
 Identities = 40/174 (22%), Positives = 68/174 (39%), Gaps = 43/174 (24%)

Query: 209 GRAYGNLGNTHYLLGNFTEATTFHKERLAIAKEFGDKAAERRAYSNLGNAHVFLGRFDVA 268
           G  Y  +GN    LG    A   H++ L IAKE+    A+ RA  N+G     +G+F  A
Sbjct: 320 GNLYSCIGNAQIELGQMEAALQSHRKDLEIAKEYDLPDAKSRALDNIGRVFARVGKFQQA 379

Query: 269 AEYYKKTLQLSRQLRDQAVEAQACYSLGNTYTLLQDYERAAEYHLRHLLIAQELADRVGE 328
            + +++ + L++                         E+   +H                
Sbjct: 380 IDTWEEKIPLAK----------------------TTLEKTWLFH---------------- 401

Query: 329 GRACWSLGNAYVSMGRPAQALTFAKKHLQISQEIGDRHGELTARMNVAQLQLVL 382
                 +G  Y+ + +  QA  + +K  Q ++E GD   +L A + VAQ Q+ L
Sbjct: 402 -----EIGRCYLELDQAWQAQNYGEKSQQCAEEEGDIEWQLNASVLVAQAQVKL 450



 Score = 38.9 bits (89), Expect = 0.010
 Identities = 42/192 (21%), Positives = 77/192 (40%), Gaps = 26/192 (13%)

Query: 68  IYSQLGNAYFYLKEHGRALEYHKHDLLLARTIGDRMGEAKASGNLGNTLKVLGRFDEAAV 127
           +YS +GNA   L +   AL+ H+ DL +A+       +++A  N+G     +G+F +A  
Sbjct: 322 LYSCIGNAQIELGQMEAALQSHRKDLEIAKEYDLPDAKSRALDNIGRVFARVGKFQQAID 381

Query: 128 CCQRHLSIAQEQGDKVGEARALYNIGNVYHAKGKQLSWNAANATQDPGHLPPDVRETLCK 187
             +  + +A+   +K       + IG  Y    +  +W A N                  
Sbjct: 382 TWEEKIPLAKTTLEKTW---LFHEIGRCYLELDQ--AWQAQN------------------ 418

Query: 188 ASEFYERNLSLVKELGDRAAQGRAYGNLGNTHYLLGNFTEATTFHKERLAIAKEFGDKAA 247
              + E++    +E GD   Q  A   +      L +F  A    ++ L  AK   +  A
Sbjct: 419 ---YGEKSQQCAEEEGDIEWQLNASVLVAQAQVKLRDFESAVNNFEKALERAKLVHNNEA 475

Query: 248 ERRAYSNLGNAH 259
           ++   S L +A+
Sbjct: 476 QQAIISALDDAN 487


>gi|22749211 transmembrane and tetratricopeptide repeat containing 2
           [Homo sapiens]
          Length = 836

 Score = 45.4 bits (106), Expect = 1e-04
 Identities = 51/236 (21%), Positives = 96/236 (40%), Gaps = 21/236 (8%)

Query: 55  VQVGTEDLKTLSAIYSQLGNAYFYLKEHGRALEYHKHDLLLARTIGDRMGEAKASGNLGN 114
           V+V    LK+L    +     ++ LK   R  ++   ++L     G ++  AKA GNLGN
Sbjct: 444 VKVQKRFLKSLIFYATATLIVFYGLKTAIRNGDWQNEEMLYRS--GIKVNPAKAWGNLGN 501

Query: 115 TLKVLGRFDEAAVCCQR-------------HLSIAQEQGDKVGEARALYNIGNVYHAKGK 161
            LK   +  EA    +              +L +  ++  +  EA   Y +         
Sbjct: 502 VLKSQSKISEAESAYRNALYYRSNMADMLYNLGLLLQENSRFAEALHYYKLAIGSRPTLA 561

Query: 162 QLSWNAANATQDPGHLPPDVRETLCKASEFYERNLSLVKELGDRAAQGRAYGNLGNTHYL 221
               N      + G    + R T  K SE  + NL        +++      NLG  ++ 
Sbjct: 562 SAYLNTGIILMNQGR-TEEARRTFLKCSEIPDENLK--DPHAHKSSVTSCLYNLGKLYHE 618

Query: 222 LGNFTEATTFHKERLAIAKEFGDKAAERRAYSNLGNAHVFLGRFDVAAEYYKKTLQ 277
            G++ EA + +KE +   ++   + A +  Y+ +G A++ L +   A  +Y ++L+
Sbjct: 619 QGHYEEALSVYKEAI---QKMPRQFAPQSLYNMMGEAYMRLSKLPEAEHWYMESLR 671



 Score = 33.1 bits (74), Expect = 0.54
 Identities = 54/225 (24%), Positives = 75/225 (33%), Gaps = 54/225 (24%)

Query: 66  SAIYSQLGNAYFYLKEHGR---ALEYHKHDLLLARTIGDRMGEAKASGNLGNTLKVLGRF 122
           S +   L N    L+E+ R   AL Y+K        IG R   A A  N G  L   GR 
Sbjct: 524 SNMADMLYNLGLLLQENSRFAEALHYYK------LAIGSRPTLASAYLNTGIILMNQGRT 577

Query: 123 DEAAVCCQRHLSIAQEQ-----GDKVGEARALYNIGNVYHAKGKQLSWNAANATQDPGHL 177
           +EA     +   I  E        K      LYN+G +YH +G                 
Sbjct: 578 EEARRTFLKCSEIPDENLKDPHAHKSSVTSCLYNLGKLYHEQG----------------- 620

Query: 178 PPDVRETLCKASEFYERNLSLVKE----LGDRAAQGRAYGNLGNTHYLLGNFTEATTFHK 233
                         YE  LS+ KE    +  + A    Y  +G  +  L    EA  ++ 
Sbjct: 621 -------------HYEEALSVYKEAIQKMPRQFAPQSLYNMMGEAYMRLSKLPEAEHWYM 667

Query: 234 ERLAIAKEFGDKAAERRAYSNLGNAHVFLGRFDVAAEYYKKTLQL 278
           E L        K     A+   G      GR   A + + K ++L
Sbjct: 668 ESLR------SKTDHIPAHLTYGKLLALTGRKSEAEKLFLKAIEL 706



 Score = 29.3 bits (64), Expect = 7.8
 Identities = 39/173 (22%), Positives = 61/173 (35%), Gaps = 25/173 (14%)

Query: 194 RNLSLVKELGDRAAQGRAYGNLGNTHYLLGNFTEATTFHKERLAIAKEFGDKAAERRAYS 253
           +N  ++   G +    +A+GNLGN        +EA + ++  L       D         
Sbjct: 478 QNEEMLYRSGIKVNPAKAWGNLGNVLKSQSKISEAESAYRNALYYRSNMAD------MLY 531

Query: 254 NLGNAHVFLGRFDVAAEYYKKTLQLSRQLRDQAVEAQACYSLGNTYTLLQDYERAAEYHL 313
           NLG       RF  A  YYK  +     L    +         NT  +L +  R  E   
Sbjct: 532 NLGLLLQENSRFAEALHYYKLAIGSRPTLASAYL---------NTGIILMNQGRTEEAR- 581

Query: 314 RHLLIAQELAD---------RVGEGRACWSLGNAYVSMGRPAQALTFAKKHLQ 357
           R  L   E+ D         +       ++LG  Y   G   +AL+  K+ +Q
Sbjct: 582 RTFLKCSEIPDENLKDPHAHKSSVTSCLYNLGKLYHEQGHYEEALSVYKEAIQ 634


>gi|28558993 intraflagellar transport 88 homolog isoform 1 [Homo
           sapiens]
          Length = 833

 Score = 44.7 bits (104), Expect = 2e-04
 Identities = 43/177 (24%), Positives = 81/177 (45%), Gaps = 21/177 (11%)

Query: 199 VKELGDRAAQGRAYGNLGNTHYLLGNFTEATTFHKERLAIAKEFGDKAAERRAYSNLGNA 258
           V E  D   +  A  NL   +Y+  +F +A+++    +A+  +  + AA     +N GN 
Sbjct: 449 VLEKKDSRVKSAAATNLSALYYMGKDFAQASSYAD--IAVNSDRYNPAA----LTNKGNT 502

Query: 259 HVFLGRFDVAAEYYKKTLQLSRQLRDQAVEAQACYSLGNTYTLLQDYERAAEYHLRHLLI 318
               G ++ AAE+YK+       LR+ +   +A Y++G TY  L   + A +  L+   I
Sbjct: 503 VFANGDYEKAAEFYKEA------LRNDSSCTEALYNIGLTYEKLNRLDEALDCFLKLHAI 556

Query: 319 AQELADRVGEGRACWSLGNAYVSMGRPAQALTFAKKHLQI---SQEIGDRHGELTAR 372
            +  A+        + + N Y  M  P+QA+ +  + + +     ++  + GEL  R
Sbjct: 557 LRNSAE------VLYQIANIYELMENPSQAIEWLMQVVSVIPTDPQVLSKLGELYDR 607



 Score = 32.7 bits (73), Expect = 0.70
 Identities = 34/131 (25%), Positives = 53/131 (40%), Gaps = 20/131 (15%)

Query: 67  AIYSQLGNAYFYLKEHGRALEYHKHDLLLARTIGDRMGEAKASGNLGNTLKVLGRFDEAA 126
           A  +  GN  F   ++ +A E++K  L    +        +A  N+G T + L R DEA 
Sbjct: 494 AALTNKGNTVFANGDYEKAAEFYKEALRNDSSC------TEALYNIGLTYEKLNRLDEAL 547

Query: 127 VCCQRHLSIAQEQGDKVGEARALYNIGNVYHA---KGKQLSWNAANATQDPGHLPPDVRE 183
            C  +  +I +        A  LY I N+Y       + + W      Q    +P D  +
Sbjct: 548 DCFLKLHAILR------NSAEVLYQIANIYELMENPSQAIEW----LMQVVSVIPTD-PQ 596

Query: 184 TLCKASEFYER 194
            L K  E Y+R
Sbjct: 597 VLSKLGELYDR 607


>gi|28329439 intraflagellar transport 88 homolog isoform 2 [Homo
           sapiens]
          Length = 824

 Score = 44.7 bits (104), Expect = 2e-04
 Identities = 43/177 (24%), Positives = 81/177 (45%), Gaps = 21/177 (11%)

Query: 199 VKELGDRAAQGRAYGNLGNTHYLLGNFTEATTFHKERLAIAKEFGDKAAERRAYSNLGNA 258
           V E  D   +  A  NL   +Y+  +F +A+++    +A+  +  + AA     +N GN 
Sbjct: 440 VLEKKDSRVKSAAATNLSALYYMGKDFAQASSYAD--IAVNSDRYNPAA----LTNKGNT 493

Query: 259 HVFLGRFDVAAEYYKKTLQLSRQLRDQAVEAQACYSLGNTYTLLQDYERAAEYHLRHLLI 318
               G ++ AAE+YK+       LR+ +   +A Y++G TY  L   + A +  L+   I
Sbjct: 494 VFANGDYEKAAEFYKEA------LRNDSSCTEALYNIGLTYEKLNRLDEALDCFLKLHAI 547

Query: 319 AQELADRVGEGRACWSLGNAYVSMGRPAQALTFAKKHLQI---SQEIGDRHGELTAR 372
            +  A+        + + N Y  M  P+QA+ +  + + +     ++  + GEL  R
Sbjct: 548 LRNSAE------VLYQIANIYELMENPSQAIEWLMQVVSVIPTDPQVLSKLGELYDR 598



 Score = 32.7 bits (73), Expect = 0.70
 Identities = 34/131 (25%), Positives = 53/131 (40%), Gaps = 20/131 (15%)

Query: 67  AIYSQLGNAYFYLKEHGRALEYHKHDLLLARTIGDRMGEAKASGNLGNTLKVLGRFDEAA 126
           A  +  GN  F   ++ +A E++K  L    +        +A  N+G T + L R DEA 
Sbjct: 485 AALTNKGNTVFANGDYEKAAEFYKEALRNDSSC------TEALYNIGLTYEKLNRLDEAL 538

Query: 127 VCCQRHLSIAQEQGDKVGEARALYNIGNVYHA---KGKQLSWNAANATQDPGHLPPDVRE 183
            C  +  +I +        A  LY I N+Y       + + W      Q    +P D  +
Sbjct: 539 DCFLKLHAILR------NSAEVLYQIANIYELMENPSQAIEW----LMQVVSVIPTD-PQ 587

Query: 184 TLCKASEFYER 194
            L K  E Y+R
Sbjct: 588 VLSKLGELYDR 598


>gi|148612821 tetratricopeptide repeat domain 29 [Homo sapiens]
          Length = 475

 Score = 42.4 bits (98), Expect = 9e-04
 Identities = 26/111 (23%), Positives = 54/111 (48%)

Query: 250 RAYSNLGNAHVFLGRFDVAAEYYKKTLQLSRQLRDQAVEAQACYSLGNTYTLLQDYERAA 309
           R Y  L +  +    +  A +   K  +++++  D+ +EA+A Y LG  +   ++YE A 
Sbjct: 235 RTYRLLSDKMLENKEYKQAIKILIKASEIAKEGSDKKMEAEASYYLGLAHLAAEEYETAL 294

Query: 310 EYHLRHLLIAQELADRVGEGRACWSLGNAYVSMGRPAQALTFAKKHLQISQ 360
                +  I+ +L D +  GR   ++     S G   +A+ + KK ++I++
Sbjct: 295 TVLDTYCKISTDLDDDLSLGRGYEAIAKVLQSQGEMTEAIKYLKKFVKIAR 345



 Score = 40.0 bits (92), Expect = 0.004
 Identities = 54/238 (22%), Positives = 92/238 (38%), Gaps = 40/238 (16%)

Query: 69  YSQLGNAYFYLKEHGRALEYHKHDLLLA--RTIGDRMGEAKASGNLGNTLKVLGRFDEAA 126
           + QL     +  E GR+L     + LL   R + D+M E K        +K+L +  E  
Sbjct: 208 FHQLTQGRIWKDETGRSLNLLACESLLRTYRLLSDKMLENK---EYKQAIKILIKASE-- 262

Query: 127 VCCQRHLSIAQEQGDKVGEARALYNIGNVYHAKGKQLSWNAANATQDPGHLPPDVRETLC 186
                   IA+E  DK  EA A Y +G              A+   +       V +T C
Sbjct: 263 --------IAKEGSDKKMEAEASYYLG-------------LAHLAAEEYETALTVLDTYC 301

Query: 187 KASEFYERNLSLVKELGDRAAQGRAYGNLGNTHYLLGNFTEATTFHKERLAIAKEFGDKA 246
           K S           +L D  + GR Y  +       G  TEA  + K+ + IA+      
Sbjct: 302 KIST----------DLDDDLSLGRGYEAIAKVLQSQGEMTEAIKYLKKFVKIARNNFQSL 351

Query: 247 AERRAYSNLGNAHVFLGRFDVAAEYYKKTLQLSRQLRDQAV--EAQACYSLGNTYTLL 302
              RA + LG+ +   G ++ A+E +++    + +L    +  E +  Y +   + ++
Sbjct: 352 DLVRASTMLGDIYNEKGYYNKASECFQQAFDTTVELMSMPLMDETKVHYGIAKAHQMM 409



 Score = 34.7 bits (78), Expect = 0.18
 Identities = 31/126 (24%), Positives = 48/126 (38%), Gaps = 7/126 (5%)

Query: 185 LCKASEFYERNLSLVKELGDRAAQGRAYGNLGNTHYLLGNFTEATTFHKERLAIAKEFGD 244
           L KASE       + KE  D+  +  A   LG  H     +  A T       I+ +  D
Sbjct: 257 LIKASE-------IAKEGSDKKMEAEASYYLGLAHLAAEEYETALTVLDTYCKISTDLDD 309

Query: 245 KAAERRAYSNLGNAHVFLGRFDVAAEYYKKTLQLSRQLRDQAVEAQACYSLGNTYTLLQD 304
             +  R Y  +       G    A +Y KK ++++R         +A   LG+ Y     
Sbjct: 310 DLSLGRGYEAIAKVLQSQGEMTEAIKYLKKFVKIARNNFQSLDLVRASTMLGDIYNEKGY 369

Query: 305 YERAAE 310
           Y +A+E
Sbjct: 370 YNKASE 375



 Score = 30.8 bits (68), Expect = 2.7
 Identities = 26/106 (24%), Positives = 41/106 (38%)

Query: 238 IAKEFGDKAAERRAYSNLGNAHVFLGRFDVAAEYYKKTLQLSRQLRDQAVEAQACYSLGN 297
           IAKE  DK  E  A   LG AH+    ++ A        ++S  L D     +   ++  
Sbjct: 263 IAKEGSDKKMEAEASYYLGLAHLAAEEYETALTVLDTYCKISTDLDDDLSLGRGYEAIAK 322

Query: 298 TYTLLQDYERAAEYHLRHLLIAQELADRVGEGRACWSLGNAYVSMG 343
                 +   A +Y  + + IA+     +   RA   LG+ Y   G
Sbjct: 323 VLQSQGEMTEAIKYLKKFVKIARNNFQSLDLVRASTMLGDIYNEKG 368


>gi|29725607 smooth muscle cell associated protein-1 isoform 2 [Homo
           sapiens]
          Length = 944

 Score = 39.7 bits (91), Expect = 0.006
 Identities = 44/160 (27%), Positives = 67/160 (41%), Gaps = 10/160 (6%)

Query: 13  PGPAARRLYSRMEASCLELALEGERLCKAGDFKTGVAFFEAAVQVGTEDLKTLSAIYSQL 72
           PG    R  +   +S  +L  EG  L K GD+   +A +  A+ +   D           
Sbjct: 6   PGTPEPRPATPGASSVEQLRKEGNELFKCGDYGGALAAYTQALGL---DATPQDQAVLHR 62

Query: 73  GNAYFYLKEHGRALEYHKHDLLLARTIGDRMGEAKASGNLGNTLKVLGRFDEAAVCCQRH 132
             A  +LK      +Y K +   ++ I    G+ KA       L+ LGR D+A +  QR 
Sbjct: 63  NRAACHLKLE----DYDKAETEASKAIEKDGGDVKALYRRSQALEKLGRLDQAVLDLQRC 118

Query: 133 LSIAQEQGDKVGEARALYNIGNVYHAKGKQLSWNAANATQ 172
           +S+  E  +KV +  AL NIG     K + +S   A   Q
Sbjct: 119 VSL--EPKNKVFQ-EALRNIGGQIQEKVRYMSSTDAKVEQ 155


>gi|89179321 smooth muscle cell associated protein-1 isoform 3 [Homo
           sapiens]
          Length = 929

 Score = 39.3 bits (90), Expect = 0.008
 Identities = 44/150 (29%), Positives = 65/150 (43%), Gaps = 11/150 (7%)

Query: 24  MEASCLE-LALEGERLCKAGDFKTGVAFFEAAVQVGTEDLKTLSAIYSQLGNAYFYLKEH 82
           M AS +E L  EG  L K GD+   +A +  A+ +   D             A  +LK  
Sbjct: 1   MTASSVEQLRKEGNELFKCGDYGGALAAYTQALGL---DATPQDQAVLHRNRAACHLKLE 57

Query: 83  GRALEYHKHDLLLARTIGDRMGEAKASGNLGNTLKVLGRFDEAAVCCQRHLSIAQEQGDK 142
               +Y K +   ++ I    G+ KA       L+ LGR D+A +  QR +S+  E  +K
Sbjct: 58  ----DYDKAETEASKAIEKDGGDVKALYRRSQALEKLGRLDQAVLDLQRCVSL--EPKNK 111

Query: 143 VGEARALYNIGNVYHAKGKQLSWNAANATQ 172
           V +  AL NIG     K + +S   A   Q
Sbjct: 112 VFQ-EALRNIGGQIQEKVRYMSSTDAKVEQ 140


>gi|83415184 transmembrane and tetratricopeptide repeat containing 1
           [Homo sapiens]
          Length = 774

 Score = 38.9 bits (89), Expect = 0.010
 Identities = 71/310 (22%), Positives = 120/310 (38%), Gaps = 53/310 (17%)

Query: 52  EAAVQVGTEDLKTLSAIYSQLGNAYFYLKEHGRALE--YHKHDLLLARTIGDRMGEAKAS 109
           E+  + G + L   + ++    N   +LK+ GR  E  YH    L           A A 
Sbjct: 361 ESLFRSGVQTLPHNAKVHYNYAN---FLKDQGRNKEAIYHYRTALKLYP-----RHASAL 412

Query: 110 GNLGNTLKVLGRFDEAAVCCQRHLSIAQEQGDKVGEARALYNIGNVYHAKGKQLSWNAAN 169
            NLG   +      EA +  QR L +  +        RAL+N+GN+   K ++    A  
Sbjct: 413 NNLGTLTRDTA---EAKMYYQRALQLHPQHN------RALFNLGNLL--KSQEKKEEAIT 461

Query: 170 ATQDPGHLPPDV-------------RETLCKASEFYERNLSLVKELGDRAAQGRAYGNLG 216
             +D     P+              +E   +A E Y+  +    +  D       + N G
Sbjct: 462 LLKDSIKYGPEFADAYSSLASLLAEQERFKEAEEIYQTGIKNCPDSSD------LHNNYG 515

Query: 217 NTHYLLGNFTEATTFHKERLAIAKEFGDKAAERRAYSNLGNAHVFLGRFDVAAEYYKKTL 276
                 G   +A   +++ + ++       +   A  NLG  +  LG   +A E+YK+ L
Sbjct: 516 VFLVDTGLPEKAVAHYQQAIKLSP------SHHVAMVNLGRLYRSLGENSMAEEWYKRAL 569

Query: 277 QLSRQLRDQAVEAQACYSLGNTYTLLQDYERAA-----EYHLRHLLIAQELADRVGEGRA 331
           Q++ +    +      Y+ G     LQ Y+ AA     +  LR L +AQ LA  +G+ + 
Sbjct: 570 QVAHKAEILSPLGALYYNTGRYEEALQIYQEAAALQPSQRELR-LALAQVLA-VMGQTKE 627

Query: 332 CWSLGNAYVS 341
              + N  VS
Sbjct: 628 AEKMTNHIVS 637



 Score = 36.6 bits (83), Expect = 0.049
 Identities = 54/208 (25%), Positives = 81/208 (38%), Gaps = 29/208 (13%)

Query: 155 VYHAK-GKQLSWNAANATQDPGHLPPDVRETLCKASEFYERNLSLVKELGDRAAQGRAYG 213
           +YH +   +L    A+A  + G L  D  E    A  +Y+R L L  +        RA  
Sbjct: 395 IYHYRTALKLYPRHASALNNLGTLTRDTAE----AKMYYQRALQLHPQ------HNRALF 444

Query: 214 NLGNTHYLLGNFTEATTFHKERLAIAKEFGDKAAERRAYSNLGNAHVFLGRFDVAAEYYK 273
           NLGN         EA T  K+ +    EF D      AYS+L +      RF  A E Y+
Sbjct: 445 NLGNLLKSQEKKEEAITLLKDSIKYGPEFAD------AYSSLASLLAEQERFKEAEEIYQ 498

Query: 274 KTLQLSRQLRDQAVEAQACYSLGNTYTLLQDYERAAEYHLRHLLIAQELADRVGEGRACW 333
             ++      D          L N Y +        E  + H   A +L+       A  
Sbjct: 499 TGIKNCPDSSD----------LHNNYGVFLVDTGLPEKAVAHYQQAIKLSP--SHHVAMV 546

Query: 334 SLGNAYVSMGRPAQALTFAKKHLQISQE 361
           +LG  Y S+G  + A  + K+ LQ++ +
Sbjct: 547 NLGRLYRSLGENSMAEEWYKRALQVAHK 574



 Score = 33.1 bits (74), Expect = 0.54
 Identities = 31/122 (25%), Positives = 51/122 (41%), Gaps = 15/122 (12%)

Query: 250 RAYSNLGNAHVFLGRFDVAAEYYKKTLQLSRQLRDQAVEAQACYSLGNTYTLLQDYERAA 309
           + + N  N     GR   A  +Y+  L+L  +       A A  +LG   TL +D   A 
Sbjct: 376 KVHYNYANFLKDQGRNKEAIYHYRTALKLYPR------HASALNNLG---TLTRDTAEAK 426

Query: 310 EYHLRHLLIAQELADRVGEGRACWSLGNAYVSMGRPAQALTFAKKHLQISQEIGDRHGEL 369
            Y+ R L +  +        RA ++LGN   S  +  +A+T  K  ++   E  D +  L
Sbjct: 427 MYYQRALQLHPQ------HNRALFNLGNLLKSQEKKEEAITLLKDSIKYGPEFADAYSSL 480

Query: 370 TA 371
            +
Sbjct: 481 AS 482


>gi|170784869 tetratricopeptide repeat domain 13 isoform b [Homo
           sapiens]
          Length = 807

 Score = 37.4 bits (85), Expect = 0.029
 Identities = 35/131 (26%), Positives = 58/131 (44%), Gaps = 13/131 (9%)

Query: 181 VRETLCKASEFYERNLSLVKELGDRAAQGRAYGNLGNTHYLLGNFTEATTFHKERLAIAK 240
           + E    A E ++++L L K       Q  A    G T +  G   EA    KE L    
Sbjct: 208 ISEDYATAHEDFQQSLELNKN------QPIAMLYKGLTFFHRGLLKEAIESFKEALKQKV 261

Query: 241 EFGDKAAERRAYSNLGNAHVFLGRFDVAAEYYKKTLQLSR-QLRDQAVEAQACYSLGNTY 299
           +F D      AY +LG A+  LG F+ A E ++K L L++  ++   +     Y  G+  
Sbjct: 262 DFID------AYKSLGQAYRELGNFEAATESFQKALLLNQNHVQTLQLRGMMLYHHGSLQ 315

Query: 300 TLLQDYERAAE 310
             L++++R  +
Sbjct: 316 EALKNFKRCLQ 326


>gi|170784867 tetratricopeptide repeat domain 13 isoform a [Homo
           sapiens]
          Length = 860

 Score = 37.4 bits (85), Expect = 0.029
 Identities = 35/131 (26%), Positives = 58/131 (44%), Gaps = 13/131 (9%)

Query: 181 VRETLCKASEFYERNLSLVKELGDRAAQGRAYGNLGNTHYLLGNFTEATTFHKERLAIAK 240
           + E    A E ++++L L K       Q  A    G T +  G   EA    KE L    
Sbjct: 261 ISEDYATAHEDFQQSLELNKN------QPIAMLYKGLTFFHRGLLKEAIESFKEALKQKV 314

Query: 241 EFGDKAAERRAYSNLGNAHVFLGRFDVAAEYYKKTLQLSR-QLRDQAVEAQACYSLGNTY 299
           +F D      AY +LG A+  LG F+ A E ++K L L++  ++   +     Y  G+  
Sbjct: 315 DFID------AYKSLGQAYRELGNFEAATESFQKALLLNQNHVQTLQLRGMMLYHHGSLQ 368

Query: 300 TLLQDYERAAE 310
             L++++R  +
Sbjct: 369 EALKNFKRCLQ 379


>gi|118402578 anaphase-promoting complex, subunit 6 [Homo sapiens]
          Length = 620

 Score = 36.6 bits (83), Expect = 0.049
 Identities = 23/96 (23%), Positives = 42/96 (43%), Gaps = 9/96 (9%)

Query: 188 ASEFYERNLSLVKELGDRAAQGR---AYGNLGNTHYLLGNFTEATTFHKERLAIAKEFGD 244
           A +++   L  +K +G+     +      NLG+    L  + EA  +H++ L +  +   
Sbjct: 421 AEKWFLDALEKIKAIGNEVTVDKWEPLLNNLGHVCRKLKKYAEALDYHRQALVLIPQ--- 477

Query: 245 KAAERRAYSNLGNAHVFLGRFDVAAEYYKKTLQLSR 280
                  YS +G  H  +G F+ A +Y+   L L R
Sbjct: 478 ---NASTYSAIGYIHSLMGNFENAVDYFHTALGLRR 510


>gi|118402580 anaphase-promoting complex, subunit 6 [Homo sapiens]
          Length = 620

 Score = 36.6 bits (83), Expect = 0.049
 Identities = 23/96 (23%), Positives = 42/96 (43%), Gaps = 9/96 (9%)

Query: 188 ASEFYERNLSLVKELGDRAAQGR---AYGNLGNTHYLLGNFTEATTFHKERLAIAKEFGD 244
           A +++   L  +K +G+     +      NLG+    L  + EA  +H++ L +  +   
Sbjct: 421 AEKWFLDALEKIKAIGNEVTVDKWEPLLNNLGHVCRKLKKYAEALDYHRQALVLIPQ--- 477

Query: 245 KAAERRAYSNLGNAHVFLGRFDVAAEYYKKTLQLSR 280
                  YS +G  H  +G F+ A +Y+   L L R
Sbjct: 478 ---NASTYSAIGYIHSLMGNFENAVDYFHTALGLRR 510


>gi|41871960 kinesin-like 8 isoform b [Homo sapiens]
          Length = 637

 Score = 34.7 bits (78), Expect = 0.18
 Identities = 42/151 (27%), Positives = 62/151 (41%), Gaps = 26/151 (17%)

Query: 98  TIG-DRMGEAKASGNLGNTLKVLGRFDEAAVCCQRHLSIAQEQGDKVGEARALYNIGNVY 156
           T+G D    A    NL       G++ EA   CQR L I ++             +G  +
Sbjct: 304 TLGPDHPAVAATLNNLAVLYGKRGKYKEAEPLCQRALEIREKV------------LGTNH 351

Query: 157 HAKGKQLSWNAANATQDPGHLPPDVRETLCKASEFYERNLSLVK-ELG-DRAAQGRAYGN 214
               KQL+ N A   Q+ G               +Y+R L++ + +LG D     R   N
Sbjct: 352 PDVAKQLN-NLALLCQNQGKYE--------AVERYYQRALAIYEGQLGPDNPNVARTKNN 402

Query: 215 LGNTHYLLGNFTEATTFHKERL--AIAKEFG 243
           L + +   G + EA T +KE L  A  +EFG
Sbjct: 403 LASCYLKQGKYAEAETLYKEILTRAHVQEFG 433


>gi|41871955 kinesin-like 8 isoform a [Homo sapiens]
          Length = 619

 Score = 34.7 bits (78), Expect = 0.18
 Identities = 42/151 (27%), Positives = 62/151 (41%), Gaps = 26/151 (17%)

Query: 98  TIG-DRMGEAKASGNLGNTLKVLGRFDEAAVCCQRHLSIAQEQGDKVGEARALYNIGNVY 156
           T+G D    A    NL       G++ EA   CQR L I ++             +G  +
Sbjct: 286 TLGPDHPAVAATLNNLAVLYGKRGKYKEAEPLCQRALEIREKV------------LGTNH 333

Query: 157 HAKGKQLSWNAANATQDPGHLPPDVRETLCKASEFYERNLSLVK-ELG-DRAAQGRAYGN 214
               KQL+ N A   Q+ G               +Y+R L++ + +LG D     R   N
Sbjct: 334 PDVAKQLN-NLALLCQNQGKYE--------AVERYYQRALAIYEGQLGPDNPNVARTKNN 384

Query: 215 LGNTHYLLGNFTEATTFHKERL--AIAKEFG 243
           L + +   G + EA T +KE L  A  +EFG
Sbjct: 385 LASCYLKQGKYAEAETLYKEILTRAHVQEFG 415


>gi|41871946 kinesin-like 8 isoform a [Homo sapiens]
          Length = 619

 Score = 34.7 bits (78), Expect = 0.18
 Identities = 42/151 (27%), Positives = 62/151 (41%), Gaps = 26/151 (17%)

Query: 98  TIG-DRMGEAKASGNLGNTLKVLGRFDEAAVCCQRHLSIAQEQGDKVGEARALYNIGNVY 156
           T+G D    A    NL       G++ EA   CQR L I ++             +G  +
Sbjct: 286 TLGPDHPAVAATLNNLAVLYGKRGKYKEAEPLCQRALEIREKV------------LGTNH 333

Query: 157 HAKGKQLSWNAANATQDPGHLPPDVRETLCKASEFYERNLSLVK-ELG-DRAAQGRAYGN 214
               KQL+ N A   Q+ G               +Y+R L++ + +LG D     R   N
Sbjct: 334 PDVAKQLN-NLALLCQNQGKYE--------AVERYYQRALAIYEGQLGPDNPNVARTKNN 384

Query: 215 LGNTHYLLGNFTEATTFHKERL--AIAKEFG 243
           L + +   G + EA T +KE L  A  +EFG
Sbjct: 385 LASCYLKQGKYAEAETLYKEILTRAHVQEFG 415


>gi|239756104 PREDICTED: tetratricopeptide repeat domain 6 [Homo
            sapiens]
          Length = 1614

 Score = 33.9 bits (76), Expect = 0.32
 Identities = 61/274 (22%), Positives = 101/274 (36%), Gaps = 55/274 (20%)

Query: 73   GNAYFYLKEHGRALEYHKHDLLLARTIGD----------RMGEAKASGNL---------- 112
            G  Y  L ++G ALE  K   L++RT G           R+ E + + N           
Sbjct: 1277 GLIYVELGQYGFALEDFKQAALISRTNGSLCHATAMCHHRINEFEEAVNFFTWALKINPC 1336

Query: 113  --------GNTLKVLGRFDEAAVCCQRHLSIAQEQGDKVGEARALYNIGNVYHAKGK-QL 163
                    GN+    G  DEA    Q+    A        +AR   + G    A+GK Q 
Sbjct: 1337 FLDAYVGRGNSYMEYGH-DEATKQAQKDFLKALHINPAYIKAR--ISFGYNLQAQGKFQK 1393

Query: 164  SWN---AANATQDPGHLPPDVRETLCKASEFYERNLSLVKELGDRAAQGRAYGNLGNTHY 220
            +WN    A  T    +L  + R  +C         +  +      +       N G  H 
Sbjct: 1394 AWNHFTIAIDTDPKNYLAYEGRAVVCLQMGNNFAAMQDINAAMKISTTAEFLTNRGVIHE 1453

Query: 221  LLGNFTEATTFHKERLAIAKEFGDKAAERRAYSNLGNAHVFLGRFDVAAEYYKKTLQLSR 280
             +G+   A   +++ + +  ++        AY N GN +    +F  A++Y+ K L+   
Sbjct: 1454 FMGHKQNAMKDYQDAITLNPKYS------LAYFNAGNIYFHHRQFSQASDYFSKALKFDP 1507

Query: 281  Q----LRDQAVEAQACYSLGNTYTLLQDYERAAE 310
            +    L ++A+          T T+L+ YE A E
Sbjct: 1508 ENEYVLMNRAI----------TNTILKKYEEAKE 1531


>gi|239750633 PREDICTED: tetratricopeptide repeat domain 6 [Homo
            sapiens]
          Length = 1614

 Score = 33.9 bits (76), Expect = 0.32
 Identities = 61/274 (22%), Positives = 101/274 (36%), Gaps = 55/274 (20%)

Query: 73   GNAYFYLKEHGRALEYHKHDLLLARTIGD----------RMGEAKASGNL---------- 112
            G  Y  L ++G ALE  K   L++RT G           R+ E + + N           
Sbjct: 1277 GLIYVELGQYGFALEDFKQAALISRTNGSLCHATAMCHHRINEFEEAVNFFTWALKINPC 1336

Query: 113  --------GNTLKVLGRFDEAAVCCQRHLSIAQEQGDKVGEARALYNIGNVYHAKGK-QL 163
                    GN+    G  DEA    Q+    A        +AR   + G    A+GK Q 
Sbjct: 1337 FLDAYVGRGNSYMEYGH-DEATKQAQKDFLKALHINPAYIKAR--ISFGYNLQAQGKFQK 1393

Query: 164  SWN---AANATQDPGHLPPDVRETLCKASEFYERNLSLVKELGDRAAQGRAYGNLGNTHY 220
            +WN    A  T    +L  + R  +C         +  +      +       N G  H 
Sbjct: 1394 AWNHFTIAIDTDPKNYLAYEGRAVVCLQMGNNFAAMQDINAAMKISTTAEFLTNRGVIHE 1453

Query: 221  LLGNFTEATTFHKERLAIAKEFGDKAAERRAYSNLGNAHVFLGRFDVAAEYYKKTLQLSR 280
             +G+   A   +++ + +  ++        AY N GN +    +F  A++Y+ K L+   
Sbjct: 1454 FMGHKQNAMKDYQDAITLNPKYS------LAYFNAGNIYFHHRQFSQASDYFSKALKFDP 1507

Query: 281  Q----LRDQAVEAQACYSLGNTYTLLQDYERAAE 310
            +    L ++A+          T T+L+ YE A E
Sbjct: 1508 ENEYVLMNRAI----------TNTILKKYEEAKE 1531


>gi|239747516 PREDICTED: hypothetical protein [Homo sapiens]
          Length = 209

 Score = 33.9 bits (76), Expect = 0.32
 Identities = 19/41 (46%), Positives = 21/41 (51%)

Query: 399 YEAQGEFQGCGGVLLPTGTDRIRSCGGVGSRPGQHGGGGSR 439
           +EA G   G GG   P   DRIR  GG+G   G  GGG  R
Sbjct: 148 WEAGGGAGGGGGSRGPAAWDRIRVNGGLGGGGGCRGGGDGR 188


  Database: hs.faa
    Posted date:  Aug 4, 2009  4:42 PM
  Number of letters in database: 18,247,518
  Number of sequences in database:  37,866
  
Lambda     K      H
   0.318    0.134    0.393 

Gapped
Lambda     K      H
   0.267   0.0410    0.140 


Matrix: BLOSUM62
Gap Penalties: Existence: 11, Extension: 1
Number of Hits to DB: 17,387,591
Number of Sequences: 37866
Number of extensions: 758084
Number of successful extensions: 2765
Number of sequences better than 10.0: 30
Number of HSP's better than 10.0 without gapping: 21
Number of HSP's successfully gapped in prelim test: 28
Number of HSP's that attempted gapping in prelim test: 2479
Number of HSP's gapped (non-prelim): 153
length of query: 457
length of database: 18,247,518
effective HSP length: 106
effective length of query: 351
effective length of database: 14,233,722
effective search space: 4996036422
effective search space used: 4996036422
T: 11
A: 40
X1: 16 ( 7.3 bits)
X2: 38 (14.6 bits)
X3: 64 (24.7 bits)
S1: 41 (21.7 bits)
S2: 64 (29.3 bits)
Search results were obtained with NCBI BLAST and RefSeq entries.