Search of human proteins with 224465233

BLASTP 2.2.11 [Jun-05-2005]


Reference: Altschul, Stephen F., Thomas L. Madden, Alejandro A. Schaffer, 
Jinghui Zhang, Zheng Zhang, Webb Miller, and David J. Lipman (1997), 
"Gapped BLAST and PSI-BLAST: a new generation of protein database search
programs",  Nucleic Acids Res. 25:3389-3402.

Query= gi|224465233 euchromatic histone-lysine N-methyltransferase 1
isoform 1 [Homo sapiens]
         (1298 letters)

Database: hs.faa 
           37,866 sequences; 18,247,518 total letters

Searching..................................................done

                                                                 Score    E
Sequences producing significant alignments:                      (bits) Value

gi|224465233 euchromatic histone-lysine N-methyltransferase 1 is...  2642   0.0  
gi|224465235 euchromatic histone-lysine N-methyltransferase 1 is...  1592   0.0  
gi|156142197 euchromatic histone-lysine N-methyltransferase 2 is...  1113   0.0  
gi|156142199 euchromatic histone-lysine N-methyltransferase 2 is...  1082   0.0  
gi|4507321 suppressor of variegation 3-9 homolog 1 [Homo sapiens]     155   2e-37
gi|13375930 suppressor of variegation 3-9 homolog 2 [Homo sapiens]    150   8e-36
gi|194306650 SET domain and mariner transposase fusion [Homo sap...   140   1e-32
gi|62988328 ankyrin repeat domain 50 [Homo sapiens]                   131   4e-30
gi|96975023 ankyrin repeat and death domain containing 1A [Homo ...   127   9e-29
gi|215598574 ankyrin 1 isoform 9 [Homo sapiens]                       124   6e-28
gi|70780359 ankyrin 1 isoform 1 [Homo sapiens]                        124   6e-28
gi|70780357 ankyrin 1 isoform 3 [Homo sapiens]                        124   6e-28
gi|70780355 ankyrin 1 isoform 2 [Homo sapiens]                        124   6e-28
gi|70780353 ankyrin 1 isoform 4 [Homo sapiens]                        124   6e-28
gi|32967601 ankyrin 3 isoform 1 [Homo sapiens]                        124   6e-28
gi|55742857 ankyrin repeat domain 6 [Homo sapiens]                    123   1e-27
gi|87239981 tankyrase, TRF1-interacting ankyrin-related ADP-ribo...   120   8e-27
gi|55741641 kinase D-interacting substrate of 220 kDa [Homo sapi...   120   8e-27
gi|68131557 ankyrin repeat domain 28 [Homo sapiens]                   119   2e-26
gi|13376842 tankyrase, TRF1-interacting ankyrin-related ADP-ribo...   115   2e-25
gi|52426737 ankyrin 2 isoform 2 [Homo sapiens]                        115   3e-25
gi|52426735 ankyrin 2 isoform 1 [Homo sapiens]                        115   3e-25
gi|188595682 ankyrin 2 isoform 3 [Homo sapiens]                       115   4e-25
gi|30425444 ankyrin repeat and kinase domain containing 1 [Homo ...   114   6e-25
gi|24233530 ankyrin repeat domain 44 [Homo sapiens]                   114   6e-25
gi|103471993 huntingtin interacting protein 14 [Homo sapiens]         112   3e-24
gi|89363047 death-associated protein kinase 1 [Homo sapiens]          109   2e-23
gi|224177469 SET domain, bifurcated 1 isoform 2 [Homo sapiens]        108   3e-23
gi|224177467 SET domain, bifurcated 1 isoform 1 [Homo sapiens]        108   3e-23
gi|46519147 ankyrin repeat and KH domain containing 1 isoform 1 ...   108   3e-23

>gi|224465233 euchromatic histone-lysine N-methyltransferase 1 isoform
            1 [Homo sapiens]
          Length = 1298

 Score = 2642 bits (6848), Expect = 0.0
 Identities = 1298/1298 (100%), Positives = 1298/1298 (100%)

Query: 1    MAAADAEAVPARGEPQQDCCVKTELLGEETPMAADEGSAEKQAGEAHMAADGETNGSCEN 60
            MAAADAEAVPARGEPQQDCCVKTELLGEETPMAADEGSAEKQAGEAHMAADGETNGSCEN
Sbjct: 1    MAAADAEAVPARGEPQQDCCVKTELLGEETPMAADEGSAEKQAGEAHMAADGETNGSCEN 60

Query: 61   SDASSHANAAKHTQDSARVNPQDGTNTLTRIAENGVSERDSEAAKQNHVTADDFVQTSVI 120
            SDASSHANAAKHTQDSARVNPQDGTNTLTRIAENGVSERDSEAAKQNHVTADDFVQTSVI
Sbjct: 61   SDASSHANAAKHTQDSARVNPQDGTNTLTRIAENGVSERDSEAAKQNHVTADDFVQTSVI 120

Query: 121  GSNGYILNKPALQAQPLRTTSTLASSLPGHAAKTLPGGAGKGRTPSAFPQTPAAPPATLG 180
            GSNGYILNKPALQAQPLRTTSTLASSLPGHAAKTLPGGAGKGRTPSAFPQTPAAPPATLG
Sbjct: 121  GSNGYILNKPALQAQPLRTTSTLASSLPGHAAKTLPGGAGKGRTPSAFPQTPAAPPATLG 180

Query: 181  EGSADTEDRKLPAPGADVKVHRARKTMPKSVVGLHAASKDPREVREARDHKEPKEEINKN 240
            EGSADTEDRKLPAPGADVKVHRARKTMPKSVVGLHAASKDPREVREARDHKEPKEEINKN
Sbjct: 181  EGSADTEDRKLPAPGADVKVHRARKTMPKSVVGLHAASKDPREVREARDHKEPKEEINKN 240

Query: 241  ISDFGRQQLLPPFPSLHQSLPQNQCYMATTKSQTACLPFVLAAAVSRKKKRRMGTYSLVP 300
            ISDFGRQQLLPPFPSLHQSLPQNQCYMATTKSQTACLPFVLAAAVSRKKKRRMGTYSLVP
Sbjct: 241  ISDFGRQQLLPPFPSLHQSLPQNQCYMATTKSQTACLPFVLAAAVSRKKKRRMGTYSLVP 300

Query: 301  KKKTKVLKQRTVIEMFKSITHSTVGSKGEKDLGASSLHVNGESLEMDSDEDDSEELEEDD 360
            KKKTKVLKQRTVIEMFKSITHSTVGSKGEKDLGASSLHVNGESLEMDSDEDDSEELEEDD
Sbjct: 301  KKKTKVLKQRTVIEMFKSITHSTVGSKGEKDLGASSLHVNGESLEMDSDEDDSEELEEDD 360

Query: 361  GHGAEQAAAFPTEDSRTSKESMSEADRAQKMDGESEEEQESVDTGEEEEGGDESDLSSES 420
            GHGAEQAAAFPTEDSRTSKESMSEADRAQKMDGESEEEQESVDTGEEEEGGDESDLSSES
Sbjct: 361  GHGAEQAAAFPTEDSRTSKESMSEADRAQKMDGESEEEQESVDTGEEEEGGDESDLSSES 420

Query: 421  SIKKKFLKRKGKTDSPWIKPARKRRRRSRKKPSGALGSESYKSSAGSAEQTAPGDSTGYM 480
            SIKKKFLKRKGKTDSPWIKPARKRRRRSRKKPSGALGSESYKSSAGSAEQTAPGDSTGYM
Sbjct: 421  SIKKKFLKRKGKTDSPWIKPARKRRRRSRKKPSGALGSESYKSSAGSAEQTAPGDSTGYM 480

Query: 481  EVSLDSLDLRVKGILSSQAEGLANGPDVLETDGLQEVPLCSCRMETPKSREITTLANNQC 540
            EVSLDSLDLRVKGILSSQAEGLANGPDVLETDGLQEVPLCSCRMETPKSREITTLANNQC
Sbjct: 481  EVSLDSLDLRVKGILSSQAEGLANGPDVLETDGLQEVPLCSCRMETPKSREITTLANNQC 540

Query: 541  MATESVDHELGRCTNSVVKYELMRPSNKAPLLVLCEDHRGRMVKHQCCPGCGYFCTAGNF 600
            MATESVDHELGRCTNSVVKYELMRPSNKAPLLVLCEDHRGRMVKHQCCPGCGYFCTAGNF
Sbjct: 541  MATESVDHELGRCTNSVVKYELMRPSNKAPLLVLCEDHRGRMVKHQCCPGCGYFCTAGNF 600

Query: 601  MECQPESSISHRFHKDCASRVNNASYCPHCGEESSKAKEVTIAKADTTSTVTPVPGQEKG 660
            MECQPESSISHRFHKDCASRVNNASYCPHCGEESSKAKEVTIAKADTTSTVTPVPGQEKG
Sbjct: 601  MECQPESSISHRFHKDCASRVNNASYCPHCGEESSKAKEVTIAKADTTSTVTPVPGQEKG 660

Query: 661  SALEGRADTTTGSAAGPPLSEDDKLQGAASHVPEGFDPTGPAGLGRPTPGLSQGPGKETL 720
            SALEGRADTTTGSAAGPPLSEDDKLQGAASHVPEGFDPTGPAGLGRPTPGLSQGPGKETL
Sbjct: 661  SALEGRADTTTGSAAGPPLSEDDKLQGAASHVPEGFDPTGPAGLGRPTPGLSQGPGKETL 720

Query: 721  ESALIALDSEKPKKLRFHPKQLYFSARQGELQKVLLMLVDGIDPNFKMEHQNKRSPLHAA 780
            ESALIALDSEKPKKLRFHPKQLYFSARQGELQKVLLMLVDGIDPNFKMEHQNKRSPLHAA
Sbjct: 721  ESALIALDSEKPKKLRFHPKQLYFSARQGELQKVLLMLVDGIDPNFKMEHQNKRSPLHAA 780

Query: 781  AEAGHVDICHMLVQAGANIDTCSEDQRTPLMEAAENNHLEAVKYLIKAGALVDPKDAEGS 840
            AEAGHVDICHMLVQAGANIDTCSEDQRTPLMEAAENNHLEAVKYLIKAGALVDPKDAEGS
Sbjct: 781  AEAGHVDICHMLVQAGANIDTCSEDQRTPLMEAAENNHLEAVKYLIKAGALVDPKDAEGS 840

Query: 841  TCLHLAAKKGHYEVVQYLLSNGQMDVNCQDDGGWTPMIWATEYKHVDLVKLLLSKGSDIN 900
            TCLHLAAKKGHYEVVQYLLSNGQMDVNCQDDGGWTPMIWATEYKHVDLVKLLLSKGSDIN
Sbjct: 841  TCLHLAAKKGHYEVVQYLLSNGQMDVNCQDDGGWTPMIWATEYKHVDLVKLLLSKGSDIN 900

Query: 901  IRDNEENICLHWAAFSGCVDIAEILLAAKCDLHAVNIHGDSPLHIAARENRYDCVVLFLS 960
            IRDNEENICLHWAAFSGCVDIAEILLAAKCDLHAVNIHGDSPLHIAARENRYDCVVLFLS
Sbjct: 901  IRDNEENICLHWAAFSGCVDIAEILLAAKCDLHAVNIHGDSPLHIAARENRYDCVVLFLS 960

Query: 961  RDSDVTLKNKEGETPLQCASLNSQVWSALQMSKALQDSAPDRPSPVERIVSRDIARGYER 1020
            RDSDVTLKNKEGETPLQCASLNSQVWSALQMSKALQDSAPDRPSPVERIVSRDIARGYER
Sbjct: 961  RDSDVTLKNKEGETPLQCASLNSQVWSALQMSKALQDSAPDRPSPVERIVSRDIARGYER 1020

Query: 1021 IPIPCVNAVDSEPCPSNYKYVSQNCVTSPMNIDRNITHLQYCVCIDDCSSSNCMCGQLSM 1080
            IPIPCVNAVDSEPCPSNYKYVSQNCVTSPMNIDRNITHLQYCVCIDDCSSSNCMCGQLSM
Sbjct: 1021 IPIPCVNAVDSEPCPSNYKYVSQNCVTSPMNIDRNITHLQYCVCIDDCSSSNCMCGQLSM 1080

Query: 1081 RCWYDKDGRLLPEFNMAEPPLIFECNHACSCWRNCRNRVVQNGLRARLQLYRTRDMGWGV 1140
            RCWYDKDGRLLPEFNMAEPPLIFECNHACSCWRNCRNRVVQNGLRARLQLYRTRDMGWGV
Sbjct: 1081 RCWYDKDGRLLPEFNMAEPPLIFECNHACSCWRNCRNRVVQNGLRARLQLYRTRDMGWGV 1140

Query: 1141 RSLQDIPPGTFVCEYVGELISDSEADVREEDSYLFDLDNKDGEVYCIDARFYGNVSRFIN 1200
            RSLQDIPPGTFVCEYVGELISDSEADVREEDSYLFDLDNKDGEVYCIDARFYGNVSRFIN
Sbjct: 1141 RSLQDIPPGTFVCEYVGELISDSEADVREEDSYLFDLDNKDGEVYCIDARFYGNVSRFIN 1200

Query: 1201 HHCEPNLVPVRVFMAHQDLRFPRIAFFSTRLIEAGEQLGFDYGERFWDIKGKLFSCRCGS 1260
            HHCEPNLVPVRVFMAHQDLRFPRIAFFSTRLIEAGEQLGFDYGERFWDIKGKLFSCRCGS
Sbjct: 1201 HHCEPNLVPVRVFMAHQDLRFPRIAFFSTRLIEAGEQLGFDYGERFWDIKGKLFSCRCGS 1260

Query: 1261 PKCRHSSAALAQRQASAAQEAQEDGLPDTSSAAAADPL 1298
            PKCRHSSAALAQRQASAAQEAQEDGLPDTSSAAAADPL
Sbjct: 1261 PKCRHSSAALAQRQASAAQEAQEDGLPDTSSAAAADPL 1298


>gi|224465235 euchromatic histone-lysine N-methyltransferase 1
           isoform 2 [Homo sapiens]
          Length = 808

 Score = 1592 bits (4123), Expect = 0.0
 Identities = 794/794 (100%), Positives = 794/794 (100%)

Query: 1   MAAADAEAVPARGEPQQDCCVKTELLGEETPMAADEGSAEKQAGEAHMAADGETNGSCEN 60
           MAAADAEAVPARGEPQQDCCVKTELLGEETPMAADEGSAEKQAGEAHMAADGETNGSCEN
Sbjct: 1   MAAADAEAVPARGEPQQDCCVKTELLGEETPMAADEGSAEKQAGEAHMAADGETNGSCEN 60

Query: 61  SDASSHANAAKHTQDSARVNPQDGTNTLTRIAENGVSERDSEAAKQNHVTADDFVQTSVI 120
           SDASSHANAAKHTQDSARVNPQDGTNTLTRIAENGVSERDSEAAKQNHVTADDFVQTSVI
Sbjct: 61  SDASSHANAAKHTQDSARVNPQDGTNTLTRIAENGVSERDSEAAKQNHVTADDFVQTSVI 120

Query: 121 GSNGYILNKPALQAQPLRTTSTLASSLPGHAAKTLPGGAGKGRTPSAFPQTPAAPPATLG 180
           GSNGYILNKPALQAQPLRTTSTLASSLPGHAAKTLPGGAGKGRTPSAFPQTPAAPPATLG
Sbjct: 121 GSNGYILNKPALQAQPLRTTSTLASSLPGHAAKTLPGGAGKGRTPSAFPQTPAAPPATLG 180

Query: 181 EGSADTEDRKLPAPGADVKVHRARKTMPKSVVGLHAASKDPREVREARDHKEPKEEINKN 240
           EGSADTEDRKLPAPGADVKVHRARKTMPKSVVGLHAASKDPREVREARDHKEPKEEINKN
Sbjct: 181 EGSADTEDRKLPAPGADVKVHRARKTMPKSVVGLHAASKDPREVREARDHKEPKEEINKN 240

Query: 241 ISDFGRQQLLPPFPSLHQSLPQNQCYMATTKSQTACLPFVLAAAVSRKKKRRMGTYSLVP 300
           ISDFGRQQLLPPFPSLHQSLPQNQCYMATTKSQTACLPFVLAAAVSRKKKRRMGTYSLVP
Sbjct: 241 ISDFGRQQLLPPFPSLHQSLPQNQCYMATTKSQTACLPFVLAAAVSRKKKRRMGTYSLVP 300

Query: 301 KKKTKVLKQRTVIEMFKSITHSTVGSKGEKDLGASSLHVNGESLEMDSDEDDSEELEEDD 360
           KKKTKVLKQRTVIEMFKSITHSTVGSKGEKDLGASSLHVNGESLEMDSDEDDSEELEEDD
Sbjct: 301 KKKTKVLKQRTVIEMFKSITHSTVGSKGEKDLGASSLHVNGESLEMDSDEDDSEELEEDD 360

Query: 361 GHGAEQAAAFPTEDSRTSKESMSEADRAQKMDGESEEEQESVDTGEEEEGGDESDLSSES 420
           GHGAEQAAAFPTEDSRTSKESMSEADRAQKMDGESEEEQESVDTGEEEEGGDESDLSSES
Sbjct: 361 GHGAEQAAAFPTEDSRTSKESMSEADRAQKMDGESEEEQESVDTGEEEEGGDESDLSSES 420

Query: 421 SIKKKFLKRKGKTDSPWIKPARKRRRRSRKKPSGALGSESYKSSAGSAEQTAPGDSTGYM 480
           SIKKKFLKRKGKTDSPWIKPARKRRRRSRKKPSGALGSESYKSSAGSAEQTAPGDSTGYM
Sbjct: 421 SIKKKFLKRKGKTDSPWIKPARKRRRRSRKKPSGALGSESYKSSAGSAEQTAPGDSTGYM 480

Query: 481 EVSLDSLDLRVKGILSSQAEGLANGPDVLETDGLQEVPLCSCRMETPKSREITTLANNQC 540
           EVSLDSLDLRVKGILSSQAEGLANGPDVLETDGLQEVPLCSCRMETPKSREITTLANNQC
Sbjct: 481 EVSLDSLDLRVKGILSSQAEGLANGPDVLETDGLQEVPLCSCRMETPKSREITTLANNQC 540

Query: 541 MATESVDHELGRCTNSVVKYELMRPSNKAPLLVLCEDHRGRMVKHQCCPGCGYFCTAGNF 600
           MATESVDHELGRCTNSVVKYELMRPSNKAPLLVLCEDHRGRMVKHQCCPGCGYFCTAGNF
Sbjct: 541 MATESVDHELGRCTNSVVKYELMRPSNKAPLLVLCEDHRGRMVKHQCCPGCGYFCTAGNF 600

Query: 601 MECQPESSISHRFHKDCASRVNNASYCPHCGEESSKAKEVTIAKADTTSTVTPVPGQEKG 660
           MECQPESSISHRFHKDCASRVNNASYCPHCGEESSKAKEVTIAKADTTSTVTPVPGQEKG
Sbjct: 601 MECQPESSISHRFHKDCASRVNNASYCPHCGEESSKAKEVTIAKADTTSTVTPVPGQEKG 660

Query: 661 SALEGRADTTTGSAAGPPLSEDDKLQGAASHVPEGFDPTGPAGLGRPTPGLSQGPGKETL 720
           SALEGRADTTTGSAAGPPLSEDDKLQGAASHVPEGFDPTGPAGLGRPTPGLSQGPGKETL
Sbjct: 661 SALEGRADTTTGSAAGPPLSEDDKLQGAASHVPEGFDPTGPAGLGRPTPGLSQGPGKETL 720

Query: 721 ESALIALDSEKPKKLRFHPKQLYFSARQGELQKVLLMLVDGIDPNFKMEHQNKRSPLHAA 780
           ESALIALDSEKPKKLRFHPKQLYFSARQGELQKVLLMLVDGIDPNFKMEHQNKRSPLHAA
Sbjct: 721 ESALIALDSEKPKKLRFHPKQLYFSARQGELQKVLLMLVDGIDPNFKMEHQNKRSPLHAA 780

Query: 781 AEAGHVDICHMLVQ 794
           AEAGHVDICHMLVQ
Sbjct: 781 AEAGHVDICHMLVQ 794


>gi|156142197 euchromatic histone-lysine N-methyltransferase 2 isoform
            a [Homo sapiens]
          Length = 1210

 Score = 1113 bits (2880), Expect = 0.0
 Identities = 580/1179 (49%), Positives = 757/1179 (64%), Gaps = 116/1179 (9%)

Query: 147  LPGHAAKTLPGGAGKG-----RTPSAFPQTPAAPPATLG-----------EGSADTEDRK 190
            L GHA K+ P    KG     R   +      +PP+              +G+A      
Sbjct: 108  LLGHATKSFPSSPSKGGSCPSRAKMSMTGAGKSPPSVQSLAMRLLSMPGAQGAAAAGSEP 167

Query: 191  LPA---PGADVKVHRARKTMPKSVVGLHAA-SKDPREVREARDHKEPKEEINKNISDFGR 246
             PA   P    KVHRARKTM K   G      K P E++  R   +    + K  SD  +
Sbjct: 168  PPATTSPEGQPKVHRARKTMSKPGNGQPPVPEKRPPEIQHFR-MSDDVHSLGKVTSDLAK 226

Query: 247  QQLLPPFPSLHQSLPQNQCYMATTKSQTACLPFVLAAAVSRKKKRRMGTYSLVPKKKTKV 306
            ++ L     L + L                              RR G  +L       +
Sbjct: 227  RRKLNSGGGLSEELGS---------------------------ARRSGEVTLTKGDPGSL 259

Query: 307  LKQRTVIEMFKSITHSTVGSKGEKDLGASSLHVNGESLEMDSDEDDSEELEEDDGHGAEQ 366
             +  TV+              G+      SL+ +  S++   D D   E+E         
Sbjct: 260  EEWETVV--------------GDD----FSLYYDSYSVDERVDSDSKSEVEA-------- 293

Query: 367  AAAFPTEDSRTSKESMSEADRAQKMDGESEEEQESVDTGEEEEGGDESDLSSESSIKKKF 426
                       +++   E +  ++ + E EEE+E  +  E+EE G++SD S  S  +K  
Sbjct: 294  ----------LTEQLSEEEEEEEEEEEEEEEEEEEEEEEEDEESGNQSDRSGSSGRRKA- 342

Query: 427  LKRKGKTDSPWIKPARKRRRRS---RKKPSGALGSESYKSSAGSAEQTAPGDSTGYMEVS 483
             K+K + DSPW+KP+RKRR+R     K+P G  G      S+G +E         YMEV 
Sbjct: 343  -KKKWRKDSPWVKPSRKRRKREPPRAKEPRGVNGV----GSSGPSE---------YMEVP 388

Query: 484  LDSLDLRVKGILSSQAEGLANGPDVLETD-GLQEVPLCSCRMETPKSREITTLANNQCMA 542
            L SL+L  +G LS    G++N    LET+ G +E+PLCSCRME PK   I+  A ++CMA
Sbjct: 389  LGSLELPSEGTLSPNHAGVSNDTSSLETERGFEELPLCSCRMEAPKIDRISERAGHKCMA 448

Query: 543  TESVDHELGRCTNSVVKYELMRPSNKAPLLVLCEDHRGRMVKHQCCPGCGYFCTAGNFME 602
            TESVD EL  C  +++K E MRPS++  L+VLCE HR RMVKH CCPGCGYFCTAG F+E
Sbjct: 449  TESVDGELSGCNAAILKRETMRPSSRVALMVLCETHRARMVKHHCCPGCGYFCTAGTFLE 508

Query: 603  CQPESSISHRFHKDCASRVNNASYCPHCGEESSKAKEVTIAKADTTS----TVTPVPGQE 658
            C P+  ++HRFHK C S++N   +CPHCGE++S+A+EVTI + D  +    T  P P   
Sbjct: 509  CHPDFRVAHRFHKACVSQLNGMVFCPHCGEDASEAQEVTIPRGDGVTPPAGTAAPAP-PP 567

Query: 659  KGSALEGRADTTTGSAAGPPLSEDDKLQGAASHVPEGFDPTGPA-----GLGRPTPGLSQ 713
                + GRADT+  SA        +  +     + +  D +GP+     G      GL  
Sbjct: 568  LSQDVPGRADTSQPSAR--MRGHGEPRRPPCDPLADTIDSSGPSLTLPNGGCLSAVGLPL 625

Query: 714  GPGKETLESALIALDSEKPKKLRFHPKQLYFSARQGELQKVLLMLVDGIDPNFKMEHQNK 773
            GPG+E LE AL+  +SE+ KKLRFHP+QLY S +QGELQKV+LML+D +DPNF+ + Q+K
Sbjct: 626  GPGREALEKALVIQESERRKKLRFHPRQLYLSVKQGELQKVILMLLDNLDPNFQSDQQSK 685

Query: 774  RSPLHAAAEAGHVDICHMLVQAGANIDTCSEDQRTPLMEAAENNHLEAVKYLIKAGALVD 833
            R+PLHAAA+ G V+ICH+L+QAGANI+   + QRTPLMEA  NNHLE  +Y+++ G  V 
Sbjct: 686  RTPLHAAAQKGSVEICHVLLQAGANINAVDKQQRTPLMEAVVNNHLEVARYMVQRGGCVY 745

Query: 834  PKDAEGSTCLHLAAKKGHYEVVQYLLSNGQMDVNCQDDGGWTPMIWATEYKHVDLVKLLL 893
             K+ +GSTCLH AAK G+ E+V  LLS GQ+DVN QD GGWTP+IWA E+KH++++++LL
Sbjct: 746  SKEEDGSTCLHHAAKIGNLEMVSLLLSTGQVDVNAQDSGGWTPIIWAAEHKHIEVIRMLL 805

Query: 894  SKGSDINIRDNEENICLHWAAFSGCVDIAEILLAAKCDLHAVNIHGDSPLHIAARENRYD 953
            ++G+D+ + DNEENICLHWA+F+G   IAE+LL A+CDLHAVN HGD+PLHIAARE+ +D
Sbjct: 806  TRGADVTLTDNEENICLHWASFTGSAAIAEVLLNARCDLHAVNYHGDTPLHIAARESYHD 865

Query: 954  CVVLFLSRDSDVTLKNKEGETPLQCASLNSQVWSALQMSKALQDSAPDRPSPVERIVSRD 1013
            CV+LFLSR ++  L+NKEG+T        S VW ALQ+++ L+    +R    E+I+ RD
Sbjct: 866  CVLLFLSRGANPELRNKEGDTAWDLTPERSDVWFALQLNRKLRLGVGNRAIRTEKIICRD 925

Query: 1014 IARGYERIPIPCVNAVDSEPCPSNYKYVSQNCVTSPMNIDRNITHLQYCVCIDDCSSSNC 1073
            +ARGYE +PIPCVN VD EPCP +YKY+S+NC TS MNIDRNITHLQ+C C+DDCSSSNC
Sbjct: 926  VARGYENVPIPCVNGVDGEPCPEDYKYISENCETSTMNIDRNITHLQHCTCVDDCSSSNC 985

Query: 1074 MCGQLSMRCWYDKDGRLLPEFNMAEPPLIFECNHACSCWRNCRNRVVQNGLRARLQLYRT 1133
            +CGQLS+RCWYDKDGRLL EFN  EPPLIFECN ACSCWRNC+NRVVQ+G++ RLQLYRT
Sbjct: 986  LCGQLSIRCWYDKDGRLLQEFNKIEPPLIFECNQACSCWRNCKNRVVQSGIKVRLQLYRT 1045

Query: 1134 RDMGWGVRSLQDIPPGTFVCEYVGELISDSEADVREEDSYLFDLDNKDGEVYCIDARFYG 1193
              MGWGVR+LQ IP GTF+CEYVGELISD+EADVRE+DSYLFDLDNKDGEVYCIDAR+YG
Sbjct: 1046 AKMGWGVRALQTIPQGTFICEYVGELISDAEADVREDDSYLFDLDNKDGEVYCIDARYYG 1105

Query: 1194 NVSRFINHHCEPNLVPVRVFMAHQDLRFPRIAFFSTRLIEAGEQLGFDYGERFWDIKGKL 1253
            N+SRFINH C+PN++PVRVFM HQDLRFPRIAFFS+R I  GE+LGFDYG+RFWDIK K 
Sbjct: 1106 NISRFINHLCDPNIIPVRVFMLHQDLRFPRIAFFSSRDIRTGEELGFDYGDRFWDIKSKY 1165

Query: 1254 FSCRCGSPKCRHSSAALAQRQASAAQ-EAQEDGLPDTSS 1291
            F+C+CGS KC+HS+ A+A  Q+  A+ +   + LP+  S
Sbjct: 1166 FTCQCGSEKCKHSAEAIALEQSRLARLDPHPELLPELGS 1204


>gi|156142199 euchromatic histone-lysine N-methyltransferase 2 isoform
            b [Homo sapiens]
          Length = 1176

 Score = 1082 bits (2798), Expect = 0.0
 Identities = 562/1176 (47%), Positives = 737/1176 (62%), Gaps = 144/1176 (12%)

Query: 147  LPGHAAKTLPGGAGKG-----RTPSAFPQTPAAPPATLG-----------EGSADTEDRK 190
            L GHA K+ P    KG     R   +      +PP+              +G+A      
Sbjct: 108  LLGHATKSFPSSPSKGGSCPSRAKMSMTGAGKSPPSVQSLAMRLLSMPGAQGAAAAGSEP 167

Query: 191  LPA---PGADVKVHRARKTMPKSVVGLHAA-SKDPREVREARDHKEPKEEINKNISDFGR 246
             PA   P    KVHRARKTM K   G      K P E++  R   +    + K  SD  +
Sbjct: 168  PPATTSPEGQPKVHRARKTMSKPGNGQPPVPEKRPPEIQHFR-MSDDVHSLGKVTSDLAK 226

Query: 247  QQLLPPFPSLHQSLPQNQCYMATTKSQTACLPFVLAAAVSRKKKRRMGTYSLVPKKKTKV 306
            ++ L     L + L                              RR G  +L       +
Sbjct: 227  RRKLNSGGGLSEELGS---------------------------ARRSGEVTLTKGDPGSL 259

Query: 307  LKQRTVIEMFKSITHSTVGSKGEKDLGASSLHVNGESLEMDSDEDDSEELEEDDGHGAEQ 366
             +  TV+              G+      SL+ +  S++   D D   E+E         
Sbjct: 260  EEWETVV--------------GDD----FSLYYDSYSVDERVDSDSKSEVEA-------- 293

Query: 367  AAAFPTEDSRTSKESMSEADRAQKMDGESEEEQESVDTGEEEEGGDESDLSSESSIKKKF 426
                       +++   E +  ++ + E EEE+E  +  E+EE G++SD S  S  +K  
Sbjct: 294  ----------LTEQLSEEEEEEEEEEEEEEEEEEEEEEEEDEESGNQSDRSGSSGRRKA- 342

Query: 427  LKRKGKTDSPWIKPARKRRRRSRKKPSGALGSESYKSSAGSAEQTAPGDSTGYMEVSLDS 486
             K+K + DSPW+KP+RKRR+R   +                                   
Sbjct: 343  -KKKWRKDSPWVKPSRKRRKREPPR----------------------------------- 366

Query: 487  LDLRVKGILSSQAEGLANGPDVLETD-GLQEVPLCSCRMETPKSREITTLANNQCMATES 545
                     + +  G++N    LET+ G +E+PLCSCRME PK   I+  A ++CMATES
Sbjct: 367  ---------AKEPRGVSNDTSSLETERGFEELPLCSCRMEAPKIDRISERAGHKCMATES 417

Query: 546  VDHELGRCTNSVVKYELMRPSNKAPLLVLCEDHRGRMVKHQCCPGCGYFCTAGNFMECQP 605
            VD EL  C  +++K E MRPS++  L+VLCE HR RMVKH CCPGCGYFCTAG F+EC P
Sbjct: 418  VDGELSGCNAAILKRETMRPSSRVALMVLCETHRARMVKHHCCPGCGYFCTAGTFLECHP 477

Query: 606  ESSISHRFHKDCASRVNNASYCPHCGEESSKAKEVTIAKADTTS----TVTPVPGQEKGS 661
            +  ++HRFHK C S++N   +CPHCGE++S+A+EVTI + D  +    T  P P      
Sbjct: 478  DFRVAHRFHKACVSQLNGMVFCPHCGEDASEAQEVTIPRGDGVTPPAGTAAPAP-PPLSQ 536

Query: 662  ALEGRADTTTGSAAGPPLSEDDKLQGAASHVPEGFDPTGPA-----GLGRPTPGLSQGPG 716
             + GRADT+  SA        +  +     + +  D +GP+     G      GL  GPG
Sbjct: 537  DVPGRADTSQPSAR--MRGHGEPRRPPCDPLADTIDSSGPSLTLPNGGCLSAVGLPLGPG 594

Query: 717  KETLESALIALDSEKPKKLRFHPKQLYFSARQGELQKVLLMLVDGIDPNFKMEHQNKRSP 776
            +E LE AL+  +SE+ KKLRFHP+QLY S +QGELQKV+LML+D +DPNF+ + Q+KR+P
Sbjct: 595  REALEKALVIQESERRKKLRFHPRQLYLSVKQGELQKVILMLLDNLDPNFQSDQQSKRTP 654

Query: 777  LHAAAEAGHVDICHMLVQAGANIDTCSEDQRTPLMEAAENNHLEAVKYLIKAGALVDPKD 836
            LHAAA+ G V+ICH+L+QAGANI+   + QRTPLMEA  NNHLE  +Y+++ G  V  K+
Sbjct: 655  LHAAAQKGSVEICHVLLQAGANINAVDKQQRTPLMEAVVNNHLEVARYMVQRGGCVYSKE 714

Query: 837  AEGSTCLHLAAKKGHYEVVQYLLSNGQMDVNCQDDGGWTPMIWATEYKHVDLVKLLLSKG 896
             +GSTCLH AAK G+ E+V  LLS GQ+DVN QD GGWTP+IWA E+KH++++++LL++G
Sbjct: 715  EDGSTCLHHAAKIGNLEMVSLLLSTGQVDVNAQDSGGWTPIIWAAEHKHIEVIRMLLTRG 774

Query: 897  SDINIRDNEENICLHWAAFSGCVDIAEILLAAKCDLHAVNIHGDSPLHIAARENRYDCVV 956
            +D+ + DNEENICLHWA+F+G   IAE+LL A+CDLHAVN HGD+PLHIAARE+ +DCV+
Sbjct: 775  ADVTLTDNEENICLHWASFTGSAAIAEVLLNARCDLHAVNYHGDTPLHIAARESYHDCVL 834

Query: 957  LFLSRDSDVTLKNKEGETPLQCASLNSQVWSALQMSKALQDSAPDRPSPVERIVSRDIAR 1016
            LFLSR ++  L+NKEG+T        S VW ALQ+++ L+    +R    E+I+ RD+AR
Sbjct: 835  LFLSRGANPELRNKEGDTAWDLTPERSDVWFALQLNRKLRLGVGNRAIRTEKIICRDVAR 894

Query: 1017 GYERIPIPCVNAVDSEPCPSNYKYVSQNCVTSPMNIDRNITHLQYCVCIDDCSSSNCMCG 1076
            GYE +PIPCVN VD EPCP +YKY+S+NC TS MNIDRNITHLQ+C C+DDCSSSNC+CG
Sbjct: 895  GYENVPIPCVNGVDGEPCPEDYKYISENCETSTMNIDRNITHLQHCTCVDDCSSSNCLCG 954

Query: 1077 QLSMRCWYDKDGRLLPEFNMAEPPLIFECNHACSCWRNCRNRVVQNGLRARLQLYRTRDM 1136
            QLS+RCWYDKDGRLL EFN  EPPLIFECN ACSCWRNC+NRVVQ+G++ RLQLYRT  M
Sbjct: 955  QLSIRCWYDKDGRLLQEFNKIEPPLIFECNQACSCWRNCKNRVVQSGIKVRLQLYRTAKM 1014

Query: 1137 GWGVRSLQDIPPGTFVCEYVGELISDSEADVREEDSYLFDLDNKDGEVYCIDARFYGNVS 1196
            GWGVR+LQ IP GTF+CEYVGELISD+EADVRE+DSYLFDLDNKDGEVYCIDAR+YGN+S
Sbjct: 1015 GWGVRALQTIPQGTFICEYVGELISDAEADVREDDSYLFDLDNKDGEVYCIDARYYGNIS 1074

Query: 1197 RFINHHCEPNLVPVRVFMAHQDLRFPRIAFFSTRLIEAGEQLGFDYGERFWDIKGKLFSC 1256
            RFINH C+PN++PVRVFM HQDLRFPRIAFFS+R I  GE+LGFDYG+RFWDIK K F+C
Sbjct: 1075 RFINHLCDPNIIPVRVFMLHQDLRFPRIAFFSSRDIRTGEELGFDYGDRFWDIKSKYFTC 1134

Query: 1257 RCGSPKCRHSSAALAQRQASAAQ-EAQEDGLPDTSS 1291
            +CGS KC+HS+ A+A  Q+  A+ +   + LP+  S
Sbjct: 1135 QCGSEKCKHSAEAIALEQSRLARLDPHPELLPELGS 1170


>gi|4507321 suppressor of variegation 3-9 homolog 1 [Homo sapiens]
          Length = 412

 Score =  155 bits (392), Expect = 2e-37
 Identities = 97/269 (36%), Positives = 140/269 (52%), Gaps = 40/269 (14%)

Query: 1027 NAVDSEPCPSNYKYVSQNCVTSPMNIDRNITHLQYCVCIDDC---SSSNCMCGQLSMRCW 1083
            N VD +  P  + Y+++  V   + +++       C C  DC    +  C  G    +  
Sbjct: 149  NEVDLDGPPRAFVYINEYRVGEGITLNQVAVG---CEC-QDCLWAPTGGCCPGASLHKFA 204

Query: 1084 YDKDGRLLPEFNMAEPPLIFECNHACSCWRNCRNRVVQNGLRARLQLYRTRD-MGWGVRS 1142
            Y+  G++     +     I+ECN  C C  +C NRVVQ G+R  L ++RT D  GWGVR+
Sbjct: 205  YNDQGQVRLRAGLP----IYECNSRCRCGYDCPNRVVQKGIRYDLCIFRTDDGRGWGVRT 260

Query: 1143 LQDIPPGTFVCEYVGELISDSEADVREE------DSYLFDLDNKDGEVYCIDARFYGNVS 1196
            L+ I   +FV EYVGE+I+  EA+ R +       +YLFDLD  + +VY +DA +YGN+S
Sbjct: 261  LEKIRKNSFVMEYVGEIITSEEAERRGQIYDRQGATYLFDLDYVE-DVYTVDAAYYGNIS 319

Query: 1197 RFINHHCEPNLVPVRVFMAHQDLRFPRIAFFSTRLIEAGEQLGFDYGERFWDI------- 1249
             F+NH C+PNL    VF+ + D R PRIAFF+TR I AGE+L FDY  +   +       
Sbjct: 320  HFVNHSCDPNLQVYNVFIDNLDERLPRIAFFATRTIRAGEELTFDYNMQVDPVDMESTRM 379

Query: 1250 --------------KGKLFSCRCGSPKCR 1264
                          K     C+CG+  CR
Sbjct: 380  DSNFGLAGLPGSPKKRVRIECKCGTESCR 408


>gi|13375930 suppressor of variegation 3-9 homolog 2 [Homo sapiens]
          Length = 350

 Score =  150 bits (379), Expect = 8e-36
 Identities = 95/257 (36%), Positives = 136/257 (52%), Gaps = 27/257 (10%)

Query: 1027 NAVDSEPCPSNYKYVSQNCVTSPMNIDRNITHLQYCVCIDDCSSSNCMCGQLSMRCWYDK 1086
            N VD E  PS++ Y+++      +++    T    C C D C    C   +  +   Y+K
Sbjct: 98   NTVDLEGPPSDFYYINEYKPAPGISLVNEATF--GCSCTD-CFFQKCCPAEAGVLLAYNK 154

Query: 1087 DGRLLPEFNMAEPPLIFECNHACSCWRNCRNRVVQNGLRARLQLYRTRD-MGWGVRSLQD 1145
            + ++     +     I+ECN  C C  +C NR+VQ G +  L ++RT +  GWGV++L  
Sbjct: 155  NQQI----KIPPGTPIYECNSRCQCGPDCPNRIVQKGTQYSLCIFRTSNGRGWGVKTLVK 210

Query: 1146 IPPGTFVCEYVGELISDSEADVREED------SYLFDLDNKDGEVYCIDARFYGNVSRFI 1199
            I   +FV EYVGE+I+  EA+ R +       +YLFDLD +  E + +DA  YGNVS F+
Sbjct: 211  IKRMSFVMEYVGEVITSEEAERRGQFYDNKGITYLFDLDYESDE-FTVDAARYGNVSHFV 269

Query: 1200 NHHCEPNLVPVRVFMAHQDLRFPRIAFFSTRLIEAGEQLGFDYGER-FWDIKGKLFS--- 1255
            NH C+PNL    VF+ + D R PRIA FSTR I AGE+L FDY  +   DI         
Sbjct: 270  NHSCDPNLQVFNVFIDNLDTRLPRIALFSTRTINAGEELTFDYQMKGSGDISSDSIDHSP 329

Query: 1256 --------CRCGSPKCR 1264
                    C+CG+  CR
Sbjct: 330  AKKRVRTVCKCGAVTCR 346


>gi|194306650 SET domain and mariner transposase fusion [Homo sapiens]
          Length = 684

 Score =  140 bits (352), Expect = 1e-32
 Identities = 95/288 (32%), Positives = 143/288 (49%), Gaps = 44/288 (15%)

Query: 1004 SPVERIVSRDIARGYERIPIPCVNAVDSEPCPSNYKYVSQNCVTSPMNIDRNITHLQYCV 1063
            +P E++   D+A G E +P   V A      P+ ++Y   + V    +ID        C+
Sbjct: 23   APTEQL---DVACGQENLP---VGAWPPGAAPAPFQYTPDHVVGPGADIDPTQITFPGCI 76

Query: 1064 CIDD-CSSSNCMCGQLSMRCWYDKDGRLLPEFNM----AEPPLIFECNHACSCWRNCRNR 1118
            C+   C    C C +      YD D   L +       AEP  +FECN  C C  +CRNR
Sbjct: 77   CVKTPCLPGTCSCLRHGEN--YD-DNSCLRDIGSGGKYAEP--VFECNVLCRCSDHCRNR 131

Query: 1119 VVQNGLRARLQLYRTRDMGWGVRSLQDIPPGTFVCEYVGELISDSEA------DVREEDS 1172
            VVQ GL+   Q+++T   GWG+R+L+ IP G FVCEY GE++  SE         + + +
Sbjct: 132  VVQKGLQFHFQVFKTHKKGWGLRTLEFIPKGRFVCEYAGEVLGFSEVQRRIHLQTKSDSN 191

Query: 1173 YLFDLDNK--DGEVY--CIDARFYGNVSRFINHHCEPNL--VPVRVFMAHQDLRFPRIAF 1226
            Y+  +     +G+V    +D  + GN+ RF+NH CEPNL  +PVR+     D   P++A 
Sbjct: 192  YIIAIREHVYNGQVMETFVDPTYIGNIGRFLNHSCEPNLLMIPVRI-----DSMVPKLAL 246

Query: 1227 FSTRLIEAGEQLGFDYGERFWDI----------KGKLFS-CRCGSPKC 1263
            F+ + I   E+L +DY  R+ ++           GKL   C CG+  C
Sbjct: 247  FAAKDIVPEEELSYDYSGRYLNLTVSEDKERLDHGKLRKPCYCGAKSC 294


>gi|62988328 ankyrin repeat domain 50 [Homo sapiens]
          Length = 1429

 Score =  131 bits (330), Expect = 4e-30
 Identities = 82/229 (35%), Positives = 123/229 (53%), Gaps = 3/229 (1%)

Query: 762 IDPNFKMEHQNK--RSPLHAAAEAGHVDICHMLVQAGANIDTCSEDQRTPLMEAAENNHL 819
           ID   +++H +K   +PL  AA  GHVD+  +L++ GA++D    + RTPL+ AA   H 
Sbjct: 735 IDRGAEVDHCDKDGMTPLLVAAYEGHVDVVDLLLEGGADVDHTDNNGRTPLLAAASMGHA 794

Query: 820 EAVKYLIKAGALVDPKDAEGSTCLHLAAKKGHYEVVQYLLSNGQMDVNCQDDGGWTPMIW 879
             V  L+  GA VD  D+EG T L +A+ +G+ EVV+ LL  G +D N +DD GWTP+  
Sbjct: 795 SVVNTLLFWGAAVDSIDSEGRTVLSIASAQGNVEVVRTLLDRG-LDENHRDDAGWTPLHM 853

Query: 880 ATEYKHVDLVKLLLSKGSDINIRDNEENICLHWAAFSGCVDIAEILLAAKCDLHAVNIHG 939
           A    H  + + L+ +G+  N  DN+  I    A+  G  D  +ILL  K ++      G
Sbjct: 854 AAFEGHRLICEALIEQGARTNEIDNDGRIPFILASQEGHYDCVQILLENKSNIDQRGYDG 913

Query: 940 DSPLHIAARENRYDCVVLFLSRDSDVTLKNKEGETPLQCASLNSQVWSA 988
            + L +AA E   D V L  S  +DV  K+ +G   L   +L +Q+  A
Sbjct: 914 RNALRVAALEGHRDIVELLFSHGADVNCKDADGRPTLYILALENQLTMA 962



 Score =  112 bits (281), Expect = 2e-24
 Identities = 80/241 (33%), Positives = 118/241 (48%), Gaps = 8/241 (3%)

Query: 745 SARQGELQKVLLMLVDGIDPNFKMEHQNKRSPLHAAAEAGHVDICHMLVQAGANIDTCSE 804
           +A  G L  V L++  G D   ++E  +  +PL  AA  GH  + + L+  GANI+   +
Sbjct: 552 AAYSGSLDVVNLLVSRGAD--LEIEDAHGHTPLTLAARQGHTKVVNCLIGCGANINHTDQ 609

Query: 805 DQRTPLMEAAENNHLEAVKYLIKAGALVDPKDAEGSTCLHLAAKKGHYEVVQYLLSNGQM 864
           D  T L  AA   H E V  L+ AG  VD  DA+  T L  AA  GH ++V  LL +G  
Sbjct: 610 DGWTALRSAAWGGHTEVVSALLYAGVKVDCADADSRTALRAAAWGGHEDIVLNLLQHG-A 668

Query: 865 DVNCQDDGGWTPMIWATEYKHVDLVKLLLSKGSDINIRDNEENICLHWAAF-----SGCV 919
           +VN  D+ G T +I A    H ++V+ LL  G+++N  D +    L  AA       G  
Sbjct: 669 EVNKADNEGRTALIAAAYMGHREIVEHLLDHGAEVNHEDVDGRTALSVAALCVPASKGHA 728

Query: 920 DIAEILLAAKCDLHAVNIHGDSPLHIAARENRYDCVVLFLSRDSDVTLKNKEGETPLQCA 979
            +  +L+    ++   +  G +PL +AA E   D V L L   +DV   +  G TPL  A
Sbjct: 729 SVVSLLIDRGAEVDHCDKDGMTPLLVAAYEGHVDVVDLLLEGGADVDHTDNNGRTPLLAA 788

Query: 980 S 980
           +
Sbjct: 789 A 789



 Score =  109 bits (273), Expect = 1e-23
 Identities = 85/308 (27%), Positives = 147/308 (47%), Gaps = 39/308 (12%)

Query: 742  LYFSARQGELQKVLLMLVDGIDPNFKMEHQNKRSPLHAAAEAGHVDICHMLVQAGANIDT 801
            L  ++ QG ++ V  +L  G+D N + +     +PLH AA  GH  IC  L++ GA  + 
Sbjct: 818  LSIASAQGNVEVVRTLLDRGLDENHRDDAG--WTPLHMAAFEGHRLICEALIEQGARTNE 875

Query: 802  CSEDQRTPLMEAAENNHLEAVKYLIKAGALVDPKDAEGSTCLHLAAKKGHYEVVQYLLSN 861
               D R P + A++  H + V+ L++  + +D +  +G   L +AA +GH ++V+ L S+
Sbjct: 876  IDNDGRIPFILASQEGHYDCVQILLENKSNIDQRGYDGRNALRVAALEGHRDIVELLFSH 935

Query: 862  GQMDVNCQD-DGGWTPMIWATEYK--------------------------------HVDL 888
            G  DVNC+D DG  T  I A E +                                H+++
Sbjct: 936  GA-DVNCKDADGRPTLYILALENQLTMAEYFLENGANVEASDAEGRTALHVSCWQGHMEM 994

Query: 889  VKLLLSKGSDINIRDNEENICLHWAAFSGCVDIAEILLAAKCDLHAVNIHGDSPLHIAAR 948
            V++L++  +D+N  DNE+   L  AA+ G V + ++L+     +      G + L IAA+
Sbjct: 995  VQVLIAYHADVNAADNEKRSALQSAAWQGHVKVVQLLIEHGAVVDHTCNQGATALCIAAQ 1054

Query: 949  ENRYDCVVLFLSRDSDVTLKNKEGETPLQCASLN--SQVWSALQMSKALQDSAPDRPSPV 1006
            E   D V + L   +D    ++ G T ++ A+ N  SQ+   L+   A   +    PSPV
Sbjct: 1055 EGHIDVVQVLLEHGADPNHADQFGRTAMRVAAKNGHSQIIKLLEKYGASSLNGCS-PSPV 1113

Query: 1007 ERIVSRDI 1014
              +  + +
Sbjct: 1114 HTMEQKPL 1121



 Score =  109 bits (272), Expect = 2e-23
 Identities = 74/214 (34%), Positives = 108/214 (50%), Gaps = 6/214 (2%)

Query: 772 NKRSPLHAAAEAGHVDICHMLVQAGANIDTCSEDQRTPLMEAAENNHLEAVKYLIKAGAL 831
           + R+ L AAA  GH DI   L+Q GA ++    + RT L+ AA   H E V++L+  GA 
Sbjct: 643 DSRTALRAAAWGGHEDIVLNLLQHGAEVNKADNEGRTALIAAAYMGHREIVEHLLDHGAE 702

Query: 832 VDPKDAEGSTCLHLAA-----KKGHYEVVQYLLSNGQMDVNCQDDGGWTPMIWATEYKHV 886
           V+ +D +G T L +AA      KGH  VV  L+  G    +C  DG  TP++ A    HV
Sbjct: 703 VNHEDVDGRTALSVAALCVPASKGHASVVSLLIDRGAEVDHCDKDG-MTPLLVAAYEGHV 761

Query: 887 DLVKLLLSKGSDINIRDNEENICLHWAAFSGCVDIAEILLAAKCDLHAVNIHGDSPLHIA 946
           D+V LLL  G+D++  DN     L  AA  G   +   LL     + +++  G + L IA
Sbjct: 762 DVVDLLLEGGADVDHTDNNGRTPLLAAASMGHASVVNTLLFWGAAVDSIDSEGRTVLSIA 821

Query: 947 ARENRYDCVVLFLSRDSDVTLKNKEGETPLQCAS 980
           + +   + V   L R  D   ++  G TPL  A+
Sbjct: 822 SAQGNVEVVRTLLDRGLDENHRDDAGWTPLHMAA 855



 Score =  108 bits (270), Expect = 3e-23
 Identities = 80/249 (32%), Positives = 120/249 (48%), Gaps = 8/249 (3%)

Query: 742 LYFSARQGELQKVLLMLVDGIDPNFKMEHQNKRSPLHAAAEAGHVDICHMLVQAGANIDT 801
           L  +ARQG  + V  ++  G   N     Q+  + L +AA  GH ++   L+ AG  +D 
Sbjct: 582 LTLAARQGHTKVVNCLI--GCGANINHTDQDGWTALRSAAWGGHTEVVSALLYAGVKVDC 639

Query: 802 CSEDQRTPLMEAAENNHLEAVKYLIKAGALVDPKDAEGSTCLHLAAKKGHYEVVQYLLSN 861
              D RT L  AA   H + V  L++ GA V+  D EG T L  AA  GH E+V++LL +
Sbjct: 640 ADADSRTALRAAAWGGHEDIVLNLLQHGAEVNKADNEGRTALIAAAYMGHREIVEHLLDH 699

Query: 862 GQMDVNCQDDGGWTPMIWA-----TEYKHVDLVKLLLSKGSDINIRDNEENICLHWAAFS 916
           G  +VN +D  G T +  A         H  +V LL+ +G++++  D +    L  AA+ 
Sbjct: 700 G-AEVNHEDVDGRTALSVAALCVPASKGHASVVSLLIDRGAEVDHCDKDGMTPLLVAAYE 758

Query: 917 GCVDIAEILLAAKCDLHAVNIHGDSPLHIAARENRYDCVVLFLSRDSDVTLKNKEGETPL 976
           G VD+ ++LL    D+   + +G +PL  AA       V   L   + V   + EG T L
Sbjct: 759 GHVDVVDLLLEGGADVDHTDNNGRTPLLAAASMGHASVVNTLLFWGAAVDSIDSEGRTVL 818

Query: 977 QCASLNSQV 985
             AS    V
Sbjct: 819 SIASAQGNV 827



 Score =  101 bits (251), Expect = 5e-21
 Identities = 74/219 (33%), Positives = 110/219 (50%), Gaps = 6/219 (2%)

Query: 772 NKRSPLHAAAEAGHVDICHMLVQAGANIDTCSEDQRTPLMEAAENNHLEAVKYLIKAGAL 831
           N R+ L  AA +G +D+ ++LV  GA+++       TPL  AA   H + V  LI  GA 
Sbjct: 544 NGRTLLANAAYSGSLDVVNLLVSRGADLEIEDAHGHTPLTLAARQGHTKVVNCLIGCGAN 603

Query: 832 VDPKDAEGSTCLHLAAKKGHYEVVQYLLSNGQMDVNCQDDGGWTPMIWATEYKHVDLVKL 891
           ++  D +G T L  AA  GH EVV  LL  G + V+C D    T +  A    H D+V  
Sbjct: 604 INHTDQDGWTALRSAAWGGHTEVVSALLYAG-VKVDCADADSRTALRAAAWGGHEDIVLN 662

Query: 892 LLSKGSDINIRDNEENICLHWAAFSGCVDIAEILLAAKCDLHAVNIHGDSPLHIA----- 946
           LL  G+++N  DNE    L  AA+ G  +I E LL    +++  ++ G + L +A     
Sbjct: 663 LLQHGAEVNKADNEGRTALIAAAYMGHREIVEHLLDHGAEVNHEDVDGRTALSVAALCVP 722

Query: 947 ARENRYDCVVLFLSRDSDVTLKNKEGETPLQCASLNSQV 985
           A +     V L + R ++V   +K+G TPL  A+    V
Sbjct: 723 ASKGHASVVSLLIDRGAEVDHCDKDGMTPLLVAAYEGHV 761



 Score = 94.0 bits (232), Expect = 8e-19
 Identities = 73/277 (26%), Positives = 124/277 (44%), Gaps = 36/277 (12%)

Query: 742  LYFSARQGELQKVLLMLVDGIDPNFKMEHQNKRSPLHAAAEAGHVDICHMLVQAGANIDT 801
            L  +A +G +  V L+L  G D +      N R+PL AAA  GH  + + L+  GA +D+
Sbjct: 752  LLVAAYEGHVDVVDLLLEGGADVDHT--DNNGRTPLLAAASMGHASVVNTLLFWGAAVDS 809

Query: 802  CSEDQRTPLMEAAENNHLEAVKYLIKAGALVDPKDAEGSTCLHLAAKKGHYEVVQYLLSN 861
               + RT L  A+   ++E V+ L+  G   + +D  G T LH+AA +GH  + + L+  
Sbjct: 810  IDSEGRTVLSIASAQGNVEVVRTLLDRGLDENHRDDAGWTPLHMAAFEGHRLICEALIEQ 869

Query: 862  GQMDVNCQDDGGWTPMIWATEYKHVD---------------------------------L 888
            G    N  D+ G  P I A++  H D                                 +
Sbjct: 870  GAR-TNEIDNDGRIPFILASQEGHYDCVQILLENKSNIDQRGYDGRNALRVAALEGHRDI 928

Query: 889  VKLLLSKGSDINIRDNEENICLHWAAFSGCVDIAEILLAAKCDLHAVNIHGDSPLHIAAR 948
            V+LL S G+D+N +D +    L+  A    + +AE  L    ++ A +  G + LH++  
Sbjct: 929  VELLFSHGADVNCKDADGRPTLYILALENQLTMAEYFLENGANVEASDAEGRTALHVSCW 988

Query: 949  ENRYDCVVLFLSRDSDVTLKNKEGETPLQCASLNSQV 985
            +   + V + ++  +DV   + E  + LQ A+    V
Sbjct: 989  QGHMEMVQVLIAYHADVNAADNEKRSALQSAAWQGHV 1025



 Score = 90.5 bits (223), Expect = 9e-18
 Identities = 61/195 (31%), Positives = 97/195 (49%), Gaps = 1/195 (0%)

Query: 787 DICHMLVQAGANIDTCSEDQRTPLMEAAENNHLEAVKYLIKAGALVDPKDAEGSTCLHLA 846
           D    L+  GA+++ C  + RT L  AA +  L+ V  L+  GA ++ +DA G T L LA
Sbjct: 526 DSIRTLLDNGASVNQCDSNGRTLLANAAYSGSLDVVNLLVSRGADLEIEDAHGHTPLTLA 585

Query: 847 AKKGHYEVVQYLLSNGQMDVNCQDDGGWTPMIWATEYKHVDLVKLLLSKGSDINIRDNEE 906
           A++GH +VV  L+  G  ++N  D  GWT +  A    H ++V  LL  G  ++  D + 
Sbjct: 586 ARQGHTKVVNCLIGCG-ANINHTDQDGWTALRSAAWGGHTEVVSALLYAGVKVDCADADS 644

Query: 907 NICLHWAAFSGCVDIAEILLAAKCDLHAVNIHGDSPLHIAARENRYDCVVLFLSRDSDVT 966
              L  AA+ G  DI   LL    +++  +  G + L  AA     + V   L   ++V 
Sbjct: 645 RTALRAAAWGGHEDIVLNLLQHGAEVNKADNEGRTALIAAAYMGHREIVEHLLDHGAEVN 704

Query: 967 LKNKEGETPLQCASL 981
            ++ +G T L  A+L
Sbjct: 705 HEDVDGRTALSVAAL 719



 Score = 59.7 bits (143), Expect = 2e-08
 Identities = 51/192 (26%), Positives = 78/192 (40%), Gaps = 32/192 (16%)

Query: 820 EAVKYLIKAGALVDPK-------------------------------DAEGSTCLHLAAK 848
           E ++ L+KAGA V+ +                               D+ G T L  AA 
Sbjct: 495 EVLQLLVKAGAHVNSEDDRTSCIVRQALEREDSIRTLLDNGASVNQCDSNGRTLLANAAY 554

Query: 849 KGHYEVVQYLLSNGQMDVNCQDDGGWTPMIWATEYKHVDLVKLLLSKGSDINIRDNEENI 908
            G  +VV  L+S G  D+  +D  G TP+  A    H  +V  L+  G++IN  D +   
Sbjct: 555 SGSLDVVNLLVSRG-ADLEIEDAHGHTPLTLAARQGHTKVVNCLIGCGANINHTDQDGWT 613

Query: 909 CLHWAAFSGCVDIAEILLAAKCDLHAVNIHGDSPLHIAARENRYDCVVLFLSRDSDVTLK 968
            L  AA+ G  ++   LL A   +   +    + L  AA     D V+  L   ++V   
Sbjct: 614 ALRSAAWGGHTEVVSALLYAGVKVDCADADSRTALRAAAWGGHEDIVLNLLQHGAEVNKA 673

Query: 969 NKEGETPLQCAS 980
           + EG T L  A+
Sbjct: 674 DNEGRTALIAAA 685


>gi|96975023 ankyrin repeat and death domain containing 1A [Homo
           sapiens]
          Length = 522

 Score =  127 bits (318), Expect = 9e-29
 Identities = 85/249 (34%), Positives = 132/249 (53%), Gaps = 5/249 (2%)

Query: 734 KLRFHPKQLYFSARQGELQKVLLMLVDGIDPNFKMEHQNKRSPLHAAAEAGHVDICHMLV 793
           +L F    L  SA  G L+ + +++  G       E ++  + LH AA+ GHV +   ++
Sbjct: 87  RLCFGMNALLLSAWFGHLRILQILVNSGA--KIHCESKDGLTLLHCAAQKGHVPVLAFIM 144

Query: 794 Q--AGANIDTCSEDQRTPLMEAAENNHLEAVKYLIKAGALVDPKDAEGSTCLHLAAKKGH 851
           +      +D   +  RT    AAE+  L+A+ +L+ +G   + KD EG+T LHLAA +GH
Sbjct: 145 EDLEDVALDHVDKLGRTAFHRAAEHGQLDALDFLVGSGCDHNVKDKEGNTALHLAAGRGH 204

Query: 852 YEVVQYLLSNGQMDVNCQDDGGWTPMIWATEYKHVDLVKLLLSKGSDINIRDNEENICLH 911
             V+Q L+  G +D+  Q+  G T +  A    H D V+LLL  GS +N    +   CLH
Sbjct: 205 MAVLQRLVDIG-LDLEEQNAEGLTALHSAAGGSHPDCVQLLLRAGSTVNALTQKNLSCLH 263

Query: 912 WAAFSGCVDIAEILLAAKCDLHAVNIHGDSPLHIAARENRYDCVVLFLSRDSDVTLKNKE 971
           +AA SG  D++ +L+ A    + V+  G SPLH+A R N    V L ++ DSDV   +  
Sbjct: 264 YAALSGSEDVSRVLIHAGGCANVVDHQGASPLHLAVRHNFPALVRLLINSDSDVNAVDNR 323

Query: 972 GETPLQCAS 980
            +TPL  A+
Sbjct: 324 QQTPLHLAA 332



 Score =  107 bits (266), Expect = 1e-22
 Identities = 75/239 (31%), Positives = 120/239 (50%), Gaps = 9/239 (3%)

Query: 725 IALDS-EKPKKLRFHPKQLYFSARQGELQKVLLMLVDGIDPNFKMEHQNKRSPLHAAAEA 783
           +ALD  +K  +  FH      +A  G+L  +  ++  G D N K +  N  + LH AA  
Sbjct: 150 VALDHVDKLGRTAFHR-----AAEHGQLDALDFLVGSGCDHNVKDKEGN--TALHLAAGR 202

Query: 784 GHVDICHMLVQAGANIDTCSEDQRTPLMEAAENNHLEAVKYLIKAGALVDPKDAEGSTCL 843
           GH+ +   LV  G +++  + +  T L  AA  +H + V+ L++AG+ V+    +  +CL
Sbjct: 203 GHMAVLQRLVDIGLDLEEQNAEGLTALHSAAGGSHPDCVQLLLRAGSTVNALTQKNLSCL 262

Query: 844 HLAAKKGHYEVVQYLLSNGQMDVNCQDDGGWTPMIWATEYKHVDLVKLLLSKGSDINIRD 903
           H AA  G  +V + L+  G    N  D  G +P+  A  +    LV+LL++  SD+N  D
Sbjct: 263 HYAALSGSEDVSRVLIHAGGC-ANVVDHQGASPLHLAVRHNFPALVRLLINSDSDVNAVD 321

Query: 904 NEENICLHWAAFSGCVDIAEILLAAKCDLHAVNIHGDSPLHIAARENRYDCVVLFLSRD 962
           N +   LH AA     DIA++LL A  DL+  +  G + L +A R N    V + +  D
Sbjct: 322 NRQQTPLHLAAEHAWQDIADMLLIAGVDLNLRDKQGKTALAVAVRSNHVSLVDMIIKAD 380



 Score = 96.3 bits (238), Expect = 2e-19
 Identities = 76/256 (29%), Positives = 124/256 (48%), Gaps = 17/256 (6%)

Query: 740 KQLYFSARQGELQKVLLMLVDGIDPNFKMEHQNKRSPLHAAAEAGHVDICHMLVQAGANI 799
           +QL+ +ARQ  + ++  ++  G   N +  +   R  LH AA AGH     +L++  A +
Sbjct: 17  RQLHEAARQNNVGRMQELI--GRRVNTRARNHVGRVALHWAAGAGHEQAVRLLLEHEAAV 74

Query: 800 DTCSEDQRTPLMEA------------AENNHLEAVKYLIKAGALVDPKDAEGSTCLHLAA 847
           D   ED    L EA            A   HL  ++ L+ +GA +  +  +G T LH AA
Sbjct: 75  D--EEDAVGALTEARLCFGMNALLLSAWFGHLRILQILVNSGAKIHCESKDGLTLLHCAA 132

Query: 848 KKGHYEVVQYLLSNGQ-MDVNCQDDGGWTPMIWATEYKHVDLVKLLLSKGSDINIRDNEE 906
           +KGH  V+ +++ + + + ++  D  G T    A E+  +D +  L+  G D N++D E 
Sbjct: 133 QKGHVPVLAFIMEDLEDVALDHVDKLGRTAFHRAAEHGQLDALDFLVGSGCDHNVKDKEG 192

Query: 907 NICLHWAAFSGCVDIAEILLAAKCDLHAVNIHGDSPLHIAARENRYDCVVLFLSRDSDVT 966
           N  LH AA  G + + + L+    DL   N  G + LH AA  +  DCV L L   S V 
Sbjct: 193 NTALHLAAGRGHMAVLQRLVDIGLDLEEQNAEGLTALHSAAGGSHPDCVQLLLRAGSTVN 252

Query: 967 LKNKEGETPLQCASLN 982
              ++  + L  A+L+
Sbjct: 253 ALTQKNLSCLHYAALS 268



 Score = 32.3 bits (72), Expect = 3.0
 Identities = 36/170 (21%), Positives = 71/170 (41%), Gaps = 13/170 (7%)

Query: 880  ATEYKHVDLVKLLLSKGSDINIRDNEENICLHWAAFSGCVDIAEILL---AAKCDLHAVN 936
            A    +V  ++ L+ +  +   R++   + LHWAA +G      +LL   AA  +  AV 
Sbjct: 22   AARQNNVGRMQELIGRRVNTRARNHVGRVALHWAAGAGHEQAVRLLLEHEAAVDEEDAVG 81

Query: 937  I-------HGDSPLHIAARENRYDCVVLFLSRDSDVTLKNKEGETPLQCASLNSQVWSAL 989
                     G + L ++A       + + ++  + +  ++K+G T L CA+    V    
Sbjct: 82   ALTEARLCFGMNALLLSAWFGHLRILQILVNSGAKIHCESKDGLTLLHCAAQKGHVPVLA 141

Query: 990  QMSKALQDSAPDRPSPVERIVSRDIARGYERIPIPCVNAVDSEPCPSNYK 1039
             + + L+D A D    V+++      R  E   +  ++ +    C  N K
Sbjct: 142  FIMEDLEDVALDH---VDKLGRTAFHRAAEHGQLDALDFLVGSGCDHNVK 188


>gi|215598574 ankyrin 1 isoform 9 [Homo sapiens]
          Length = 1897

 Score =  124 bits (311), Expect = 6e-28
 Identities = 84/256 (32%), Positives = 126/256 (49%), Gaps = 3/256 (1%)

Query: 724 LIALDSEKPKKLRFHPKQLYFSARQGELQKVLLMLVDGIDPNFKMEHQNKRSPLHAAAEA 783
           L+  D+E       H   L+ +A  G  +   ++L  G  PN +    N  +PLH A + 
Sbjct: 357 LLQYDAEIDDITLDHLTPLHVAAHCGHHRVAKVLLDKGAKPNSRA--LNGFTPLHIACKK 414

Query: 784 GHVDICHMLVQAGANIDTCSEDQRTPLMEAAENNHLEAVKYLIKAGALVDPKDAEGSTCL 843
            HV +  +L++ GA+ID  +E   TPL  A+   HL  VK L++ GA  +  + +  T L
Sbjct: 415 NHVRVMELLLKTGASIDAVTESGLTPLHVASFMGHLPIVKNLLQRGASPNVSNVKVETPL 474

Query: 844 HLAAKKGHYEVVQYLLSNGQMDVNCQDDGGWTPMIWATEYKHVDLVKLLLSKGSDINIRD 903
           H+AA+ GH EV +YLL N +  VN +     TP+  A    H ++VKLLL   ++ N+  
Sbjct: 475 HMAARAGHTEVAKYLLQN-KAKVNAKAKDDQTPLHCAARIGHTNMVKLLLENNANPNLAT 533

Query: 904 NEENICLHWAAFSGCVDIAEILLAAKCDLHAVNIHGDSPLHIAARENRYDCVVLFLSRDS 963
              +  LH AA  G V+    LL  +     +   G +PLH+AA+  +     L L RD+
Sbjct: 534 TAGHTPLHIAAREGHVETVLALLEKEASQACMTKKGFTPLHVAAKYGKVRVAELLLERDA 593

Query: 964 DVTLKNKEGETPLQCA 979
                 K G TPL  A
Sbjct: 594 HPNAAGKNGLTPLHVA 609



 Score =  123 bits (309), Expect = 1e-27
 Identities = 81/250 (32%), Positives = 126/250 (50%), Gaps = 3/250 (1%)

Query: 742 LYFSARQGELQKVLLMLVDGIDPNFKMEHQNKRSPLHAAAEAGHVDICHMLVQAGANIDT 801
           L+ +AR G ++   ++L  G     K +  N  SP+H AA+  H+D   +L+Q  A ID 
Sbjct: 309 LHCAARNGHVRISEILLDHGAPIQAKTK--NGLSPIHMAAQGDHLDCVRLLLQYDAEIDD 366

Query: 802 CSEDQRTPLMEAAENNHLEAVKYLIKAGALVDPKDAEGSTCLHLAAKKGHYEVVQYLLSN 861
            + D  TPL  AA   H    K L+  GA  + +   G T LH+A KK H  V++ LL  
Sbjct: 367 ITLDHLTPLHVAAHCGHHRVAKVLLDKGAKPNSRALNGFTPLHIACKKNHVRVMELLLKT 426

Query: 862 GQMDVNCQDDGGWTPMIWATEYKHVDLVKLLLSKGSDINIRDNEENICLHWAAFSGCVDI 921
           G   ++   + G TP+  A+   H+ +VK LL +G+  N+ + +    LH AA +G  ++
Sbjct: 427 G-ASIDAVTESGLTPLHVASFMGHLPIVKNLLQRGASPNVSNVKVETPLHMAARAGHTEV 485

Query: 922 AEILLAAKCDLHAVNIHGDSPLHIAARENRYDCVVLFLSRDSDVTLKNKEGETPLQCASL 981
           A+ LL  K  ++A      +PLH AAR    + V L L  +++  L    G TPL  A+ 
Sbjct: 486 AKYLLQNKAKVNAKAKDDQTPLHCAARIGHTNMVKLLLENNANPNLATTAGHTPLHIAAR 545

Query: 982 NSQVWSALQM 991
              V + L +
Sbjct: 546 EGHVETVLAL 555



 Score =  119 bits (299), Expect = 1e-26
 Identities = 77/239 (32%), Positives = 127/239 (53%), Gaps = 3/239 (1%)

Query: 742 LYFSARQGELQKVLLMLVDGIDPNFKMEHQNKRSPLHAAAEAGHVDICHMLVQAGANIDT 801
           L+ ++R+G +  V L+L  G     K +  ++ +PLH AA  GHV I  +L+  GA I  
Sbjct: 276 LHIASRRGNVIMVRLLLDRGAQIETKTK--DELTPLHCAARNGHVRISEILLDHGAPIQA 333

Query: 802 CSEDQRTPLMEAAENNHLEAVKYLIKAGALVDPKDAEGSTCLHLAAKKGHYEVVQYLLSN 861
            +++  +P+  AA+ +HL+ V+ L++  A +D    +  T LH+AA  GH+ V + LL  
Sbjct: 334 KTKNGLSPIHMAAQGDHLDCVRLLLQYDAEIDDITLDHLTPLHVAAHCGHHRVAKVLLDK 393

Query: 862 GQMDVNCQDDGGWTPMIWATEYKHVDLVKLLLSKGSDINIRDNEENICLHWAAFSGCVDI 921
           G    N +   G+TP+  A +  HV +++LLL  G+ I+         LH A+F G + I
Sbjct: 394 GAKP-NSRALNGFTPLHIACKKNHVRVMELLLKTGASIDAVTESGLTPLHVASFMGHLPI 452

Query: 922 AEILLAAKCDLHAVNIHGDSPLHIAARENRYDCVVLFLSRDSDVTLKNKEGETPLQCAS 980
            + LL      +  N+  ++PLH+AAR    +     L   + V  K K+ +TPL CA+
Sbjct: 453 VKNLLQRGASPNVSNVKVETPLHMAARAGHTEVAKYLLQNKAKVNAKAKDDQTPLHCAA 511



 Score =  112 bits (281), Expect = 2e-24
 Identities = 78/244 (31%), Positives = 120/244 (49%), Gaps = 3/244 (1%)

Query: 742 LYFSARQGELQKVLLMLVDGIDPNFKMEHQNKRSPLHAAAEAGHVDICHMLVQAGANIDT 801
           L+ +AR G  +    +L +    N K +  + ++PLH AA  GH ++  +L++  AN + 
Sbjct: 474 LHMAARAGHTEVAKYLLQNKAKVNAKAK--DDQTPLHCAARIGHTNMVKLLLENNANPNL 531

Query: 802 CSEDQRTPLMEAAENNHLEAVKYLIKAGALVDPKDAEGSTCLHLAAKKGHYEVVQYLLSN 861
            +    TPL  AA   H+E V  L++  A       +G T LH+AAK G   V + LL  
Sbjct: 532 ATTAGHTPLHIAAREGHVETVLALLEKEASQACMTKKGFTPLHVAAKYGKVRVAELLLER 591

Query: 862 GQMDVNCQDDGGWTPMIWATEYKHVDLVKLLLSKGSDINIRDNEENICLHWAAFSGCVDI 921
                N     G TP+  A  + ++D+VKLLL +G   +         LH AA    V++
Sbjct: 592 -DAHPNAAGKNGLTPLHVAVHHNNLDIVKLLLPRGGSPHSPAWNGYTPLHIAAKQNQVEV 650

Query: 922 AEILLAAKCDLHAVNIHGDSPLHIAARENRYDCVVLFLSRDSDVTLKNKEGETPLQCASL 981
           A  LL      +A ++ G +PLH+AA+E   + V L LS+ ++  L NK G TPL   + 
Sbjct: 651 ARSLLQYGGSANAESVQGVTPLHLAAQEGHAEMVALLLSKQANGNLGNKSGLTPLHLVAQ 710

Query: 982 NSQV 985
              V
Sbjct: 711 EGHV 714



 Score =  108 bits (271), Expect = 3e-23
 Identities = 75/241 (31%), Positives = 120/241 (49%), Gaps = 7/241 (2%)

Query: 742 LYFSARQGELQKVLLMLVDGIDPNFKMEHQNKR--SPLHAAAEAGHVDICHMLVQAGANI 799
           L+ +AR+G ++ VL +L    +         K+  +PLH AA+ G V +  +L++  A+ 
Sbjct: 540 LHIAAREGHVETVLALL----EKEASQACMTKKGFTPLHVAAKYGKVRVAELLLERDAHP 595

Query: 800 DTCSEDQRTPLMEAAENNHLEAVKYLIKAGALVDPKDAEGSTCLHLAAKKGHYEVVQYLL 859
           +   ++  TPL  A  +N+L+ VK L+  G         G T LH+AAK+   EV + LL
Sbjct: 596 NAAGKNGLTPLHVAVHHNNLDIVKLLLPRGGSPHSPAWNGYTPLHIAAKQNQVEVARSLL 655

Query: 860 SNGQMDVNCQDDGGWTPMIWATEYKHVDLVKLLLSKGSDINIRDNEENICLHWAAFSGCV 919
             G    N +   G TP+  A +  H ++V LLLSK ++ N+ +      LH  A  G V
Sbjct: 656 QYGG-SANAESVQGVTPLHLAAQEGHAEMVALLLSKQANGNLGNKSGLTPLHLVAQEGHV 714

Query: 920 DIAEILLAAKCDLHAVNIHGDSPLHIAARENRYDCVVLFLSRDSDVTLKNKEGETPLQCA 979
            +A++L+     + A    G +PLH+A+       V   L   +DV  K K G +PL  A
Sbjct: 715 PVADVLIKHGVMVDATTRMGYTPLHVASHYGNIKLVKFLLQHQADVNAKTKLGYSPLHQA 774

Query: 980 S 980
           +
Sbjct: 775 A 775



 Score =  108 bits (271), Expect = 3e-23
 Identities = 79/264 (29%), Positives = 132/264 (50%), Gaps = 9/264 (3%)

Query: 720 LESALIALDSEKPK----KLRFHPKQLYFSARQGELQKVLLMLVDGIDPNFKMEHQNKRS 775
           +E+ L  L+ E  +    K  F P  L+ +A+ G+++   L+L     PN     +N  +
Sbjct: 549 VETVLALLEKEASQACMTKKGFTP--LHVAAKYGKVRVAELLLERDAHPN--AAGKNGLT 604

Query: 776 PLHAAAEAGHVDICHMLVQAGANIDTCSEDQRTPLMEAAENNHLEAVKYLIKAGALVDPK 835
           PLH A    ++DI  +L+  G +  + + +  TPL  AA+ N +E  + L++ G   + +
Sbjct: 605 PLHVAVHHNNLDIVKLLLPRGGSPHSPAWNGYTPLHIAAKQNQVEVARSLLQYGGSANAE 664

Query: 836 DAEGSTCLHLAAKKGHYEVVQYLLSNGQMDVNCQDDGGWTPMIWATEYKHVDLVKLLLSK 895
             +G T LHLAA++GH E+V  LLS  Q + N  +  G TP+    +  HV +  +L+  
Sbjct: 665 SVQGVTPLHLAAQEGHAEMVALLLSK-QANGNLGNKSGLTPLHLVAQEGHVPVADVLIKH 723

Query: 896 GSDINIRDNEENICLHWAAFSGCVDIAEILLAAKCDLHAVNIHGDSPLHIAARENRYDCV 955
           G  ++         LH A+  G + + + LL  + D++A    G SPLH AA++   D V
Sbjct: 724 GVMVDATTRMGYTPLHVASHYGNIKLVKFLLQHQADVNAKTKLGYSPLHQAAQQGHTDIV 783

Query: 956 VLFLSRDSDVTLKNKEGETPLQCA 979
            L L   +     + +G TPL  A
Sbjct: 784 TLLLKNGASPNEVSSDGTTPLAIA 807



 Score =  106 bits (264), Expect = 2e-22
 Identities = 82/270 (30%), Positives = 132/270 (48%), Gaps = 32/270 (11%)

Query: 745 SARQGELQKVLLMLVDGIDPNFKMEHQNKRSPLHAAAEAGHVDICHMLVQAGANIDTCSE 804
           +AR G L K L  L +G+D N    +QN  + LH A++ GHV +   L+     ++T ++
Sbjct: 52  AARSGNLDKALDHLRNGVDINTC--NQNGLNGLHLASKEGHVKMVVELLHKEIILETTTK 109

Query: 805 DQRTPLMEAAENNHLEAVKYLIKAGALVDPKDAEGSTCLHLAAKKGHYEVVQYLLSNGQM 864
              T L  AA     E V+ L+  GA V+ +  +G T L++AA++ H EVV++LL NG  
Sbjct: 110 KGNTALHIAALAGQDEVVRELVNYGANVNAQSQKGFTPLYMAAQENHLEVVKFLLENG-A 168

Query: 865 DVNCQDDGGWTPMIWATEYKHVDLVKLLLSKGSDINIR--------------------DN 904
           + N   + G+TP+  A +  H ++V  L++ G+   +R                     N
Sbjct: 169 NQNVATEDGFTPLAVALQQGHENVVAHLINYGTKGKVRLPALHIAARNDDTRTAAVLLQN 228

Query: 905 EEN---------ICLHWAAFSGCVDIAEILLAAKCDLHAVNIHGDSPLHIAARENRYDCV 955
           + N           LH AA    +++A++LL     ++    +G +PLHIA+R      V
Sbjct: 229 DPNPDVLSKTGFTPLHIAAHYENLNVAQLLLNRGASVNFTPQNGITPLHIASRRGNVIMV 288

Query: 956 VLFLSRDSDVTLKNKEGETPLQCASLNSQV 985
            L L R + +  K K+  TPL CA+ N  V
Sbjct: 289 RLLLDRGAQIETKTKDELTPLHCAARNGHV 318



 Score =  103 bits (257), Expect = 1e-21
 Identities = 76/245 (31%), Positives = 114/245 (46%), Gaps = 30/245 (12%)

Query: 765 NFKMEHQNKRSPLHAAAEAGHVDICHMLVQAGANIDTCSEDQRTPLMEAAENNHLEAVKY 824
           N   + Q   +PL+ AA+  H+++   L++ GAN +  +ED  TPL  A +  H   V +
Sbjct: 136 NVNAQSQKGFTPLYMAAQENHLEVVKFLLENGANQNVATEDGFTPLAVALQQGHENVVAH 195

Query: 825 LIKAGAL-----------------------------VDPKDAEGSTCLHLAAKKGHYEVV 855
           LI  G                                D     G T LH+AA   +  V 
Sbjct: 196 LINYGTKGKVRLPALHIAARNDDTRTAAVLLQNDPNPDVLSKTGFTPLHIAAHYENLNVA 255

Query: 856 QYLLSNGQMDVNCQDDGGWTPMIWATEYKHVDLVKLLLSKGSDINIRDNEENICLHWAAF 915
           Q LL+ G   VN     G TP+  A+   +V +V+LLL +G+ I  +  +E   LH AA 
Sbjct: 256 QLLLNRGA-SVNFTPQNGITPLHIASRRGNVIMVRLLLDRGAQIETKTKDELTPLHCAAR 314

Query: 916 SGCVDIAEILLAAKCDLHAVNIHGDSPLHIAARENRYDCVVLFLSRDSDVTLKNKEGETP 975
           +G V I+EILL     + A   +G SP+H+AA+ +  DCV L L  D+++     +  TP
Sbjct: 315 NGHVRISEILLDHGAPIQAKTKNGLSPIHMAAQGDHLDCVRLLLQYDAEIDDITLDHLTP 374

Query: 976 LQCAS 980
           L  A+
Sbjct: 375 LHVAA 379



 Score = 95.5 bits (236), Expect = 3e-19
 Identities = 69/207 (33%), Positives = 101/207 (48%), Gaps = 3/207 (1%)

Query: 742 LYFSARQGELQKVLLMLVDGIDPNFKMEHQNKRSPLHAAAEAGHVDICHMLVQAGANIDT 801
           L+ +     L  V L+L  G  P+      N  +PLH AA+   V++   L+Q G + + 
Sbjct: 606 LHVAVHHNNLDIVKLLLPRGGSPHSPA--WNGYTPLHIAAKQNQVEVARSLLQYGGSANA 663

Query: 802 CSEDQRTPLMEAAENNHLEAVKYLIKAGALVDPKDAEGSTCLHLAAKKGHYEVVQYLLSN 861
            S    TPL  AA+  H E V  L+   A  +  +  G T LHL A++GH  V   L+ +
Sbjct: 664 ESVQGVTPLHLAAQEGHAEMVALLLSKQANGNLGNKSGLTPLHLVAQEGHVPVADVLIKH 723

Query: 862 GQMDVNCQDDGGWTPMIWATEYKHVDLVKLLLSKGSDINIRDNEENICLHWAAFSGCVDI 921
           G M V+     G+TP+  A+ Y ++ LVK LL   +D+N +       LH AA  G  DI
Sbjct: 724 GVM-VDATTRMGYTPLHVASHYGNIKLVKFLLQHQADVNAKTKLGYSPLHQAAQQGHTDI 782

Query: 922 AEILLAAKCDLHAVNIHGDSPLHIAAR 948
             +LL      + V+  G +PL IA R
Sbjct: 783 VTLLLKNGASPNEVSSDGTTPLAIAKR 809



 Score = 87.0 bits (214), Expect = 1e-16
 Identities = 56/184 (30%), Positives = 96/184 (52%), Gaps = 3/184 (1%)

Query: 742 LYFSARQGELQKVLLMLVDGIDPNFKMEHQNKRSPLHAAAEAGHVDICHMLVQAGANIDT 801
           L+ +A+Q +++    +L  G   N   E     +PLH AA+ GH ++  +L+   AN + 
Sbjct: 639 LHIAAKQNQVEVARSLLQYGGSAN--AESVQGVTPLHLAAQEGHAEMVALLLSKQANGNL 696

Query: 802 CSEDQRTPLMEAAENNHLEAVKYLIKAGALVDPKDAEGSTCLHLAAKKGHYEVVQYLLSN 861
            ++   TPL   A+  H+     LIK G +VD     G T LH+A+  G+ ++V++LL +
Sbjct: 697 GNKSGLTPLHLVAQEGHVPVADVLIKHGVMVDATTRMGYTPLHVASHYGNIKLVKFLLQH 756

Query: 862 GQMDVNCQDDGGWTPMIWATEYKHVDLVKLLLSKGSDINIRDNEENICLHWAAFSGCVDI 921
            Q DVN +   G++P+  A +  H D+V LLL  G+  N   ++    L  A   G + +
Sbjct: 757 -QADVNAKTKLGYSPLHQAAQQGHTDIVTLLLKNGASPNEVSSDGTTPLAIAKRLGYISV 815

Query: 922 AEIL 925
            ++L
Sbjct: 816 TDVL 819



 Score = 77.0 bits (188), Expect = 1e-13
 Identities = 55/215 (25%), Positives = 105/215 (48%), Gaps = 6/215 (2%)

Query: 692 VPEGFDPTGPAGLGRPTPGLSQGPGKETLESALIALDSEKPKKLRFHPKQLYFSARQGEL 751
           +P G  P  PA  G     ++    +  +  +L+        +       L+ +A++G  
Sbjct: 622 LPRGGSPHSPAWNGYTPLHIAAKQNQVEVARSLLQYGGSANAESVQGVTPLHLAAQEGHA 681

Query: 752 QKVLLMLVDGIDPNFKMEHQNKRSPLHAAAEAGHVDICHMLVQAGANIDTCSEDQRTPLM 811
           + V L+L    + N  + +++  +PLH  A+ GHV +  +L++ G  +D  +    TPL 
Sbjct: 682 EMVALLLSKQANGN--LGNKSGLTPLHLVAQEGHVPVADVLIKHGVMVDATTRMGYTPLH 739

Query: 812 EAAENNHLEAVKYLIKAGALVDPKDAEGSTCLHLAAKKGHYEVVQYLLSNGQMDVNCQDD 871
            A+   +++ VK+L++  A V+ K   G + LH AA++GH ++V  LL NG        D
Sbjct: 740 VASHYGNIKLVKFLLQHQADVNAKTKLGYSPLHQAAQQGHTDIVTLLLKNGASPNEVSSD 799

Query: 872 GGWTPMIWATEYKHV---DLVKLLLSKGSDINIRD 903
            G TP+  A    ++   D++K++  + S + + D
Sbjct: 800 -GTTPLAIAKRLGYISVTDVLKVVTDETSFVLVSD 833



 Score = 64.3 bits (155), Expect = 7e-10
 Identities = 59/242 (24%), Positives = 94/242 (38%), Gaps = 61/242 (25%)

Query: 805 DQRTPLMEAAENNHLEAVKYLIKAGALVDPKDAEGSTCLHLAAKKGHYEVVQYLLS---- 860
           D  T  + AA + +L+     ++ G  ++  +  G   LHLA+K+GH ++V  LL     
Sbjct: 44  DAATSFLRAARSGNLDKALDHLRNGVDINTCNQNGLNGLHLASKEGHVKMVVELLHKEII 103

Query: 861 ----------------------------NGQMDVNCQDDGGWTPMIWATEYKHVDLVKLL 892
                                       N   +VN Q   G+TP+  A +  H+++VK L
Sbjct: 104 LETTTKKGNTALHIAALAGQDEVVRELVNYGANVNAQSQKGFTPLYMAAQENHLEVVKFL 163

Query: 893 LSKGSDINI-------------RDNEENI----------------CLHWAAFSGCVDIAE 923
           L  G++ N+             +   EN+                 LH AA +     A 
Sbjct: 164 LENGANQNVATEDGFTPLAVALQQGHENVVAHLINYGTKGKVRLPALHIAARNDDTRTAA 223

Query: 924 ILLAAKCDLHAVNIHGDSPLHIAARENRYDCVVLFLSRDSDVTLKNKEGETPLQCASLNS 983
           +LL    +   ++  G +PLHIAA     +   L L+R + V    + G TPL  AS   
Sbjct: 224 VLLQNDPNPDVLSKTGFTPLHIAAHYENLNVAQLLLNRGASVNFTPQNGITPLHIASRRG 283

Query: 984 QV 985
            V
Sbjct: 284 NV 285


>gi|70780359 ankyrin 1 isoform 1 [Homo sapiens]
          Length = 1881

 Score =  124 bits (311), Expect = 6e-28
 Identities = 84/256 (32%), Positives = 126/256 (49%), Gaps = 3/256 (1%)

Query: 724 LIALDSEKPKKLRFHPKQLYFSARQGELQKVLLMLVDGIDPNFKMEHQNKRSPLHAAAEA 783
           L+  D+E       H   L+ +A  G  +   ++L  G  PN +    N  +PLH A + 
Sbjct: 324 LLQYDAEIDDITLDHLTPLHVAAHCGHHRVAKVLLDKGAKPNSRA--LNGFTPLHIACKK 381

Query: 784 GHVDICHMLVQAGANIDTCSEDQRTPLMEAAENNHLEAVKYLIKAGALVDPKDAEGSTCL 843
            HV +  +L++ GA+ID  +E   TPL  A+   HL  VK L++ GA  +  + +  T L
Sbjct: 382 NHVRVMELLLKTGASIDAVTESGLTPLHVASFMGHLPIVKNLLQRGASPNVSNVKVETPL 441

Query: 844 HLAAKKGHYEVVQYLLSNGQMDVNCQDDGGWTPMIWATEYKHVDLVKLLLSKGSDINIRD 903
           H+AA+ GH EV +YLL N +  VN +     TP+  A    H ++VKLLL   ++ N+  
Sbjct: 442 HMAARAGHTEVAKYLLQN-KAKVNAKAKDDQTPLHCAARIGHTNMVKLLLENNANPNLAT 500

Query: 904 NEENICLHWAAFSGCVDIAEILLAAKCDLHAVNIHGDSPLHIAARENRYDCVVLFLSRDS 963
              +  LH AA  G V+    LL  +     +   G +PLH+AA+  +     L L RD+
Sbjct: 501 TAGHTPLHIAAREGHVETVLALLEKEASQACMTKKGFTPLHVAAKYGKVRVAELLLERDA 560

Query: 964 DVTLKNKEGETPLQCA 979
                 K G TPL  A
Sbjct: 561 HPNAAGKNGLTPLHVA 576



 Score =  123 bits (309), Expect = 1e-27
 Identities = 81/250 (32%), Positives = 126/250 (50%), Gaps = 3/250 (1%)

Query: 742 LYFSARQGELQKVLLMLVDGIDPNFKMEHQNKRSPLHAAAEAGHVDICHMLVQAGANIDT 801
           L+ +AR G ++   ++L  G     K +  N  SP+H AA+  H+D   +L+Q  A ID 
Sbjct: 276 LHCAARNGHVRISEILLDHGAPIQAKTK--NGLSPIHMAAQGDHLDCVRLLLQYDAEIDD 333

Query: 802 CSEDQRTPLMEAAENNHLEAVKYLIKAGALVDPKDAEGSTCLHLAAKKGHYEVVQYLLSN 861
            + D  TPL  AA   H    K L+  GA  + +   G T LH+A KK H  V++ LL  
Sbjct: 334 ITLDHLTPLHVAAHCGHHRVAKVLLDKGAKPNSRALNGFTPLHIACKKNHVRVMELLLKT 393

Query: 862 GQMDVNCQDDGGWTPMIWATEYKHVDLVKLLLSKGSDINIRDNEENICLHWAAFSGCVDI 921
           G   ++   + G TP+  A+   H+ +VK LL +G+  N+ + +    LH AA +G  ++
Sbjct: 394 G-ASIDAVTESGLTPLHVASFMGHLPIVKNLLQRGASPNVSNVKVETPLHMAARAGHTEV 452

Query: 922 AEILLAAKCDLHAVNIHGDSPLHIAARENRYDCVVLFLSRDSDVTLKNKEGETPLQCASL 981
           A+ LL  K  ++A      +PLH AAR    + V L L  +++  L    G TPL  A+ 
Sbjct: 453 AKYLLQNKAKVNAKAKDDQTPLHCAARIGHTNMVKLLLENNANPNLATTAGHTPLHIAAR 512

Query: 982 NSQVWSALQM 991
              V + L +
Sbjct: 513 EGHVETVLAL 522



 Score =  119 bits (299), Expect = 1e-26
 Identities = 77/239 (32%), Positives = 127/239 (53%), Gaps = 3/239 (1%)

Query: 742 LYFSARQGELQKVLLMLVDGIDPNFKMEHQNKRSPLHAAAEAGHVDICHMLVQAGANIDT 801
           L+ ++R+G +  V L+L  G     K +  ++ +PLH AA  GHV I  +L+  GA I  
Sbjct: 243 LHIASRRGNVIMVRLLLDRGAQIETKTK--DELTPLHCAARNGHVRISEILLDHGAPIQA 300

Query: 802 CSEDQRTPLMEAAENNHLEAVKYLIKAGALVDPKDAEGSTCLHLAAKKGHYEVVQYLLSN 861
            +++  +P+  AA+ +HL+ V+ L++  A +D    +  T LH+AA  GH+ V + LL  
Sbjct: 301 KTKNGLSPIHMAAQGDHLDCVRLLLQYDAEIDDITLDHLTPLHVAAHCGHHRVAKVLLDK 360

Query: 862 GQMDVNCQDDGGWTPMIWATEYKHVDLVKLLLSKGSDINIRDNEENICLHWAAFSGCVDI 921
           G    N +   G+TP+  A +  HV +++LLL  G+ I+         LH A+F G + I
Sbjct: 361 GAKP-NSRALNGFTPLHIACKKNHVRVMELLLKTGASIDAVTESGLTPLHVASFMGHLPI 419

Query: 922 AEILLAAKCDLHAVNIHGDSPLHIAARENRYDCVVLFLSRDSDVTLKNKEGETPLQCAS 980
            + LL      +  N+  ++PLH+AAR    +     L   + V  K K+ +TPL CA+
Sbjct: 420 VKNLLQRGASPNVSNVKVETPLHMAARAGHTEVAKYLLQNKAKVNAKAKDDQTPLHCAA 478



 Score =  112 bits (281), Expect = 2e-24
 Identities = 78/244 (31%), Positives = 120/244 (49%), Gaps = 3/244 (1%)

Query: 742 LYFSARQGELQKVLLMLVDGIDPNFKMEHQNKRSPLHAAAEAGHVDICHMLVQAGANIDT 801
           L+ +AR G  +    +L +    N K +  + ++PLH AA  GH ++  +L++  AN + 
Sbjct: 441 LHMAARAGHTEVAKYLLQNKAKVNAKAK--DDQTPLHCAARIGHTNMVKLLLENNANPNL 498

Query: 802 CSEDQRTPLMEAAENNHLEAVKYLIKAGALVDPKDAEGSTCLHLAAKKGHYEVVQYLLSN 861
            +    TPL  AA   H+E V  L++  A       +G T LH+AAK G   V + LL  
Sbjct: 499 ATTAGHTPLHIAAREGHVETVLALLEKEASQACMTKKGFTPLHVAAKYGKVRVAELLLER 558

Query: 862 GQMDVNCQDDGGWTPMIWATEYKHVDLVKLLLSKGSDINIRDNEENICLHWAAFSGCVDI 921
                N     G TP+  A  + ++D+VKLLL +G   +         LH AA    V++
Sbjct: 559 -DAHPNAAGKNGLTPLHVAVHHNNLDIVKLLLPRGGSPHSPAWNGYTPLHIAAKQNQVEV 617

Query: 922 AEILLAAKCDLHAVNIHGDSPLHIAARENRYDCVVLFLSRDSDVTLKNKEGETPLQCASL 981
           A  LL      +A ++ G +PLH+AA+E   + V L LS+ ++  L NK G TPL   + 
Sbjct: 618 ARSLLQYGGSANAESVQGVTPLHLAAQEGHAEMVALLLSKQANGNLGNKSGLTPLHLVAQ 677

Query: 982 NSQV 985
              V
Sbjct: 678 EGHV 681



 Score =  108 bits (271), Expect = 3e-23
 Identities = 75/241 (31%), Positives = 120/241 (49%), Gaps = 7/241 (2%)

Query: 742 LYFSARQGELQKVLLMLVDGIDPNFKMEHQNKR--SPLHAAAEAGHVDICHMLVQAGANI 799
           L+ +AR+G ++ VL +L    +         K+  +PLH AA+ G V +  +L++  A+ 
Sbjct: 507 LHIAAREGHVETVLALL----EKEASQACMTKKGFTPLHVAAKYGKVRVAELLLERDAHP 562

Query: 800 DTCSEDQRTPLMEAAENNHLEAVKYLIKAGALVDPKDAEGSTCLHLAAKKGHYEVVQYLL 859
           +   ++  TPL  A  +N+L+ VK L+  G         G T LH+AAK+   EV + LL
Sbjct: 563 NAAGKNGLTPLHVAVHHNNLDIVKLLLPRGGSPHSPAWNGYTPLHIAAKQNQVEVARSLL 622

Query: 860 SNGQMDVNCQDDGGWTPMIWATEYKHVDLVKLLLSKGSDINIRDNEENICLHWAAFSGCV 919
             G    N +   G TP+  A +  H ++V LLLSK ++ N+ +      LH  A  G V
Sbjct: 623 QYGG-SANAESVQGVTPLHLAAQEGHAEMVALLLSKQANGNLGNKSGLTPLHLVAQEGHV 681

Query: 920 DIAEILLAAKCDLHAVNIHGDSPLHIAARENRYDCVVLFLSRDSDVTLKNKEGETPLQCA 979
            +A++L+     + A    G +PLH+A+       V   L   +DV  K K G +PL  A
Sbjct: 682 PVADVLIKHGVMVDATTRMGYTPLHVASHYGNIKLVKFLLQHQADVNAKTKLGYSPLHQA 741

Query: 980 S 980
           +
Sbjct: 742 A 742



 Score =  108 bits (271), Expect = 3e-23
 Identities = 79/264 (29%), Positives = 132/264 (50%), Gaps = 9/264 (3%)

Query: 720 LESALIALDSEKPK----KLRFHPKQLYFSARQGELQKVLLMLVDGIDPNFKMEHQNKRS 775
           +E+ L  L+ E  +    K  F P  L+ +A+ G+++   L+L     PN     +N  +
Sbjct: 516 VETVLALLEKEASQACMTKKGFTP--LHVAAKYGKVRVAELLLERDAHPN--AAGKNGLT 571

Query: 776 PLHAAAEAGHVDICHMLVQAGANIDTCSEDQRTPLMEAAENNHLEAVKYLIKAGALVDPK 835
           PLH A    ++DI  +L+  G +  + + +  TPL  AA+ N +E  + L++ G   + +
Sbjct: 572 PLHVAVHHNNLDIVKLLLPRGGSPHSPAWNGYTPLHIAAKQNQVEVARSLLQYGGSANAE 631

Query: 836 DAEGSTCLHLAAKKGHYEVVQYLLSNGQMDVNCQDDGGWTPMIWATEYKHVDLVKLLLSK 895
             +G T LHLAA++GH E+V  LLS  Q + N  +  G TP+    +  HV +  +L+  
Sbjct: 632 SVQGVTPLHLAAQEGHAEMVALLLSK-QANGNLGNKSGLTPLHLVAQEGHVPVADVLIKH 690

Query: 896 GSDINIRDNEENICLHWAAFSGCVDIAEILLAAKCDLHAVNIHGDSPLHIAARENRYDCV 955
           G  ++         LH A+  G + + + LL  + D++A    G SPLH AA++   D V
Sbjct: 691 GVMVDATTRMGYTPLHVASHYGNIKLVKFLLQHQADVNAKTKLGYSPLHQAAQQGHTDIV 750

Query: 956 VLFLSRDSDVTLKNKEGETPLQCA 979
            L L   +     + +G TPL  A
Sbjct: 751 TLLLKNGASPNEVSSDGTTPLAIA 774



 Score =  106 bits (264), Expect = 2e-22
 Identities = 82/270 (30%), Positives = 132/270 (48%), Gaps = 32/270 (11%)

Query: 745 SARQGELQKVLLMLVDGIDPNFKMEHQNKRSPLHAAAEAGHVDICHMLVQAGANIDTCSE 804
           +AR G L K L  L +G+D N    +QN  + LH A++ GHV +   L+     ++T ++
Sbjct: 19  AARSGNLDKALDHLRNGVDINTC--NQNGLNGLHLASKEGHVKMVVELLHKEIILETTTK 76

Query: 805 DQRTPLMEAAENNHLEAVKYLIKAGALVDPKDAEGSTCLHLAAKKGHYEVVQYLLSNGQM 864
              T L  AA     E V+ L+  GA V+ +  +G T L++AA++ H EVV++LL NG  
Sbjct: 77  KGNTALHIAALAGQDEVVRELVNYGANVNAQSQKGFTPLYMAAQENHLEVVKFLLENG-A 135

Query: 865 DVNCQDDGGWTPMIWATEYKHVDLVKLLLSKGSDINIR--------------------DN 904
           + N   + G+TP+  A +  H ++V  L++ G+   +R                     N
Sbjct: 136 NQNVATEDGFTPLAVALQQGHENVVAHLINYGTKGKVRLPALHIAARNDDTRTAAVLLQN 195

Query: 905 EEN---------ICLHWAAFSGCVDIAEILLAAKCDLHAVNIHGDSPLHIAARENRYDCV 955
           + N           LH AA    +++A++LL     ++    +G +PLHIA+R      V
Sbjct: 196 DPNPDVLSKTGFTPLHIAAHYENLNVAQLLLNRGASVNFTPQNGITPLHIASRRGNVIMV 255

Query: 956 VLFLSRDSDVTLKNKEGETPLQCASLNSQV 985
            L L R + +  K K+  TPL CA+ N  V
Sbjct: 256 RLLLDRGAQIETKTKDELTPLHCAARNGHV 285



 Score =  103 bits (257), Expect = 1e-21
 Identities = 76/245 (31%), Positives = 114/245 (46%), Gaps = 30/245 (12%)

Query: 765 NFKMEHQNKRSPLHAAAEAGHVDICHMLVQAGANIDTCSEDQRTPLMEAAENNHLEAVKY 824
           N   + Q   +PL+ AA+  H+++   L++ GAN +  +ED  TPL  A +  H   V +
Sbjct: 103 NVNAQSQKGFTPLYMAAQENHLEVVKFLLENGANQNVATEDGFTPLAVALQQGHENVVAH 162

Query: 825 LIKAGAL-----------------------------VDPKDAEGSTCLHLAAKKGHYEVV 855
           LI  G                                D     G T LH+AA   +  V 
Sbjct: 163 LINYGTKGKVRLPALHIAARNDDTRTAAVLLQNDPNPDVLSKTGFTPLHIAAHYENLNVA 222

Query: 856 QYLLSNGQMDVNCQDDGGWTPMIWATEYKHVDLVKLLLSKGSDINIRDNEENICLHWAAF 915
           Q LL+ G   VN     G TP+  A+   +V +V+LLL +G+ I  +  +E   LH AA 
Sbjct: 223 QLLLNRGA-SVNFTPQNGITPLHIASRRGNVIMVRLLLDRGAQIETKTKDELTPLHCAAR 281

Query: 916 SGCVDIAEILLAAKCDLHAVNIHGDSPLHIAARENRYDCVVLFLSRDSDVTLKNKEGETP 975
           +G V I+EILL     + A   +G SP+H+AA+ +  DCV L L  D+++     +  TP
Sbjct: 282 NGHVRISEILLDHGAPIQAKTKNGLSPIHMAAQGDHLDCVRLLLQYDAEIDDITLDHLTP 341

Query: 976 LQCAS 980
           L  A+
Sbjct: 342 LHVAA 346



 Score = 95.5 bits (236), Expect = 3e-19
 Identities = 69/207 (33%), Positives = 101/207 (48%), Gaps = 3/207 (1%)

Query: 742 LYFSARQGELQKVLLMLVDGIDPNFKMEHQNKRSPLHAAAEAGHVDICHMLVQAGANIDT 801
           L+ +     L  V L+L  G  P+      N  +PLH AA+   V++   L+Q G + + 
Sbjct: 573 LHVAVHHNNLDIVKLLLPRGGSPHSPA--WNGYTPLHIAAKQNQVEVARSLLQYGGSANA 630

Query: 802 CSEDQRTPLMEAAENNHLEAVKYLIKAGALVDPKDAEGSTCLHLAAKKGHYEVVQYLLSN 861
            S    TPL  AA+  H E V  L+   A  +  +  G T LHL A++GH  V   L+ +
Sbjct: 631 ESVQGVTPLHLAAQEGHAEMVALLLSKQANGNLGNKSGLTPLHLVAQEGHVPVADVLIKH 690

Query: 862 GQMDVNCQDDGGWTPMIWATEYKHVDLVKLLLSKGSDINIRDNEENICLHWAAFSGCVDI 921
           G M V+     G+TP+  A+ Y ++ LVK LL   +D+N +       LH AA  G  DI
Sbjct: 691 GVM-VDATTRMGYTPLHVASHYGNIKLVKFLLQHQADVNAKTKLGYSPLHQAAQQGHTDI 749

Query: 922 AEILLAAKCDLHAVNIHGDSPLHIAAR 948
             +LL      + V+  G +PL IA R
Sbjct: 750 VTLLLKNGASPNEVSSDGTTPLAIAKR 776



 Score = 87.0 bits (214), Expect = 1e-16
 Identities = 56/184 (30%), Positives = 96/184 (52%), Gaps = 3/184 (1%)

Query: 742 LYFSARQGELQKVLLMLVDGIDPNFKMEHQNKRSPLHAAAEAGHVDICHMLVQAGANIDT 801
           L+ +A+Q +++    +L  G   N   E     +PLH AA+ GH ++  +L+   AN + 
Sbjct: 606 LHIAAKQNQVEVARSLLQYGGSAN--AESVQGVTPLHLAAQEGHAEMVALLLSKQANGNL 663

Query: 802 CSEDQRTPLMEAAENNHLEAVKYLIKAGALVDPKDAEGSTCLHLAAKKGHYEVVQYLLSN 861
            ++   TPL   A+  H+     LIK G +VD     G T LH+A+  G+ ++V++LL +
Sbjct: 664 GNKSGLTPLHLVAQEGHVPVADVLIKHGVMVDATTRMGYTPLHVASHYGNIKLVKFLLQH 723

Query: 862 GQMDVNCQDDGGWTPMIWATEYKHVDLVKLLLSKGSDINIRDNEENICLHWAAFSGCVDI 921
            Q DVN +   G++P+  A +  H D+V LLL  G+  N   ++    L  A   G + +
Sbjct: 724 -QADVNAKTKLGYSPLHQAAQQGHTDIVTLLLKNGASPNEVSSDGTTPLAIAKRLGYISV 782

Query: 922 AEIL 925
            ++L
Sbjct: 783 TDVL 786



 Score = 77.0 bits (188), Expect = 1e-13
 Identities = 55/215 (25%), Positives = 105/215 (48%), Gaps = 6/215 (2%)

Query: 692 VPEGFDPTGPAGLGRPTPGLSQGPGKETLESALIALDSEKPKKLRFHPKQLYFSARQGEL 751
           +P G  P  PA  G     ++    +  +  +L+        +       L+ +A++G  
Sbjct: 589 LPRGGSPHSPAWNGYTPLHIAAKQNQVEVARSLLQYGGSANAESVQGVTPLHLAAQEGHA 648

Query: 752 QKVLLMLVDGIDPNFKMEHQNKRSPLHAAAEAGHVDICHMLVQAGANIDTCSEDQRTPLM 811
           + V L+L    + N  + +++  +PLH  A+ GHV +  +L++ G  +D  +    TPL 
Sbjct: 649 EMVALLLSKQANGN--LGNKSGLTPLHLVAQEGHVPVADVLIKHGVMVDATTRMGYTPLH 706

Query: 812 EAAENNHLEAVKYLIKAGALVDPKDAEGSTCLHLAAKKGHYEVVQYLLSNGQMDVNCQDD 871
            A+   +++ VK+L++  A V+ K   G + LH AA++GH ++V  LL NG        D
Sbjct: 707 VASHYGNIKLVKFLLQHQADVNAKTKLGYSPLHQAAQQGHTDIVTLLLKNGASPNEVSSD 766

Query: 872 GGWTPMIWATEYKHV---DLVKLLLSKGSDINIRD 903
            G TP+  A    ++   D++K++  + S + + D
Sbjct: 767 -GTTPLAIAKRLGYISVTDVLKVVTDETSFVLVSD 800



 Score = 64.3 bits (155), Expect = 7e-10
 Identities = 59/242 (24%), Positives = 94/242 (38%), Gaps = 61/242 (25%)

Query: 805 DQRTPLMEAAENNHLEAVKYLIKAGALVDPKDAEGSTCLHLAAKKGHYEVVQYLLS---- 860
           D  T  + AA + +L+     ++ G  ++  +  G   LHLA+K+GH ++V  LL     
Sbjct: 11  DAATSFLRAARSGNLDKALDHLRNGVDINTCNQNGLNGLHLASKEGHVKMVVELLHKEII 70

Query: 861 ----------------------------NGQMDVNCQDDGGWTPMIWATEYKHVDLVKLL 892
                                       N   +VN Q   G+TP+  A +  H+++VK L
Sbjct: 71  LETTTKKGNTALHIAALAGQDEVVRELVNYGANVNAQSQKGFTPLYMAAQENHLEVVKFL 130

Query: 893 LSKGSDINI-------------RDNEENI----------------CLHWAAFSGCVDIAE 923
           L  G++ N+             +   EN+                 LH AA +     A 
Sbjct: 131 LENGANQNVATEDGFTPLAVALQQGHENVVAHLINYGTKGKVRLPALHIAARNDDTRTAA 190

Query: 924 ILLAAKCDLHAVNIHGDSPLHIAARENRYDCVVLFLSRDSDVTLKNKEGETPLQCASLNS 983
           +LL    +   ++  G +PLHIAA     +   L L+R + V    + G TPL  AS   
Sbjct: 191 VLLQNDPNPDVLSKTGFTPLHIAAHYENLNVAQLLLNRGASVNFTPQNGITPLHIASRRG 250

Query: 984 QV 985
            V
Sbjct: 251 NV 252


>gi|70780357 ankyrin 1 isoform 3 [Homo sapiens]
          Length = 1880

 Score =  124 bits (311), Expect = 6e-28
 Identities = 84/256 (32%), Positives = 126/256 (49%), Gaps = 3/256 (1%)

Query: 724 LIALDSEKPKKLRFHPKQLYFSARQGELQKVLLMLVDGIDPNFKMEHQNKRSPLHAAAEA 783
           L+  D+E       H   L+ +A  G  +   ++L  G  PN +    N  +PLH A + 
Sbjct: 324 LLQYDAEIDDITLDHLTPLHVAAHCGHHRVAKVLLDKGAKPNSRA--LNGFTPLHIACKK 381

Query: 784 GHVDICHMLVQAGANIDTCSEDQRTPLMEAAENNHLEAVKYLIKAGALVDPKDAEGSTCL 843
            HV +  +L++ GA+ID  +E   TPL  A+   HL  VK L++ GA  +  + +  T L
Sbjct: 382 NHVRVMELLLKTGASIDAVTESGLTPLHVASFMGHLPIVKNLLQRGASPNVSNVKVETPL 441

Query: 844 HLAAKKGHYEVVQYLLSNGQMDVNCQDDGGWTPMIWATEYKHVDLVKLLLSKGSDINIRD 903
           H+AA+ GH EV +YLL N +  VN +     TP+  A    H ++VKLLL   ++ N+  
Sbjct: 442 HMAARAGHTEVAKYLLQN-KAKVNAKAKDDQTPLHCAARIGHTNMVKLLLENNANPNLAT 500

Query: 904 NEENICLHWAAFSGCVDIAEILLAAKCDLHAVNIHGDSPLHIAARENRYDCVVLFLSRDS 963
              +  LH AA  G V+    LL  +     +   G +PLH+AA+  +     L L RD+
Sbjct: 501 TAGHTPLHIAAREGHVETVLALLEKEASQACMTKKGFTPLHVAAKYGKVRVAELLLERDA 560

Query: 964 DVTLKNKEGETPLQCA 979
                 K G TPL  A
Sbjct: 561 HPNAAGKNGLTPLHVA 576



 Score =  123 bits (309), Expect = 1e-27
 Identities = 81/250 (32%), Positives = 126/250 (50%), Gaps = 3/250 (1%)

Query: 742 LYFSARQGELQKVLLMLVDGIDPNFKMEHQNKRSPLHAAAEAGHVDICHMLVQAGANIDT 801
           L+ +AR G ++   ++L  G     K +  N  SP+H AA+  H+D   +L+Q  A ID 
Sbjct: 276 LHCAARNGHVRISEILLDHGAPIQAKTK--NGLSPIHMAAQGDHLDCVRLLLQYDAEIDD 333

Query: 802 CSEDQRTPLMEAAENNHLEAVKYLIKAGALVDPKDAEGSTCLHLAAKKGHYEVVQYLLSN 861
            + D  TPL  AA   H    K L+  GA  + +   G T LH+A KK H  V++ LL  
Sbjct: 334 ITLDHLTPLHVAAHCGHHRVAKVLLDKGAKPNSRALNGFTPLHIACKKNHVRVMELLLKT 393

Query: 862 GQMDVNCQDDGGWTPMIWATEYKHVDLVKLLLSKGSDINIRDNEENICLHWAAFSGCVDI 921
           G   ++   + G TP+  A+   H+ +VK LL +G+  N+ + +    LH AA +G  ++
Sbjct: 394 G-ASIDAVTESGLTPLHVASFMGHLPIVKNLLQRGASPNVSNVKVETPLHMAARAGHTEV 452

Query: 922 AEILLAAKCDLHAVNIHGDSPLHIAARENRYDCVVLFLSRDSDVTLKNKEGETPLQCASL 981
           A+ LL  K  ++A      +PLH AAR    + V L L  +++  L    G TPL  A+ 
Sbjct: 453 AKYLLQNKAKVNAKAKDDQTPLHCAARIGHTNMVKLLLENNANPNLATTAGHTPLHIAAR 512

Query: 982 NSQVWSALQM 991
              V + L +
Sbjct: 513 EGHVETVLAL 522



 Score =  119 bits (299), Expect = 1e-26
 Identities = 77/239 (32%), Positives = 127/239 (53%), Gaps = 3/239 (1%)

Query: 742 LYFSARQGELQKVLLMLVDGIDPNFKMEHQNKRSPLHAAAEAGHVDICHMLVQAGANIDT 801
           L+ ++R+G +  V L+L  G     K +  ++ +PLH AA  GHV I  +L+  GA I  
Sbjct: 243 LHIASRRGNVIMVRLLLDRGAQIETKTK--DELTPLHCAARNGHVRISEILLDHGAPIQA 300

Query: 802 CSEDQRTPLMEAAENNHLEAVKYLIKAGALVDPKDAEGSTCLHLAAKKGHYEVVQYLLSN 861
            +++  +P+  AA+ +HL+ V+ L++  A +D    +  T LH+AA  GH+ V + LL  
Sbjct: 301 KTKNGLSPIHMAAQGDHLDCVRLLLQYDAEIDDITLDHLTPLHVAAHCGHHRVAKVLLDK 360

Query: 862 GQMDVNCQDDGGWTPMIWATEYKHVDLVKLLLSKGSDINIRDNEENICLHWAAFSGCVDI 921
           G    N +   G+TP+  A +  HV +++LLL  G+ I+         LH A+F G + I
Sbjct: 361 GAKP-NSRALNGFTPLHIACKKNHVRVMELLLKTGASIDAVTESGLTPLHVASFMGHLPI 419

Query: 922 AEILLAAKCDLHAVNIHGDSPLHIAARENRYDCVVLFLSRDSDVTLKNKEGETPLQCAS 980
            + LL      +  N+  ++PLH+AAR    +     L   + V  K K+ +TPL CA+
Sbjct: 420 VKNLLQRGASPNVSNVKVETPLHMAARAGHTEVAKYLLQNKAKVNAKAKDDQTPLHCAA 478



 Score =  112 bits (281), Expect = 2e-24
 Identities = 78/244 (31%), Positives = 120/244 (49%), Gaps = 3/244 (1%)

Query: 742 LYFSARQGELQKVLLMLVDGIDPNFKMEHQNKRSPLHAAAEAGHVDICHMLVQAGANIDT 801
           L+ +AR G  +    +L +    N K +  + ++PLH AA  GH ++  +L++  AN + 
Sbjct: 441 LHMAARAGHTEVAKYLLQNKAKVNAKAK--DDQTPLHCAARIGHTNMVKLLLENNANPNL 498

Query: 802 CSEDQRTPLMEAAENNHLEAVKYLIKAGALVDPKDAEGSTCLHLAAKKGHYEVVQYLLSN 861
            +    TPL  AA   H+E V  L++  A       +G T LH+AAK G   V + LL  
Sbjct: 499 ATTAGHTPLHIAAREGHVETVLALLEKEASQACMTKKGFTPLHVAAKYGKVRVAELLLER 558

Query: 862 GQMDVNCQDDGGWTPMIWATEYKHVDLVKLLLSKGSDINIRDNEENICLHWAAFSGCVDI 921
                N     G TP+  A  + ++D+VKLLL +G   +         LH AA    V++
Sbjct: 559 -DAHPNAAGKNGLTPLHVAVHHNNLDIVKLLLPRGGSPHSPAWNGYTPLHIAAKQNQVEV 617

Query: 922 AEILLAAKCDLHAVNIHGDSPLHIAARENRYDCVVLFLSRDSDVTLKNKEGETPLQCASL 981
           A  LL      +A ++ G +PLH+AA+E   + V L LS+ ++  L NK G TPL   + 
Sbjct: 618 ARSLLQYGGSANAESVQGVTPLHLAAQEGHAEMVALLLSKQANGNLGNKSGLTPLHLVAQ 677

Query: 982 NSQV 985
              V
Sbjct: 678 EGHV 681



 Score =  108 bits (271), Expect = 3e-23
 Identities = 75/241 (31%), Positives = 120/241 (49%), Gaps = 7/241 (2%)

Query: 742 LYFSARQGELQKVLLMLVDGIDPNFKMEHQNKR--SPLHAAAEAGHVDICHMLVQAGANI 799
           L+ +AR+G ++ VL +L    +         K+  +PLH AA+ G V +  +L++  A+ 
Sbjct: 507 LHIAAREGHVETVLALL----EKEASQACMTKKGFTPLHVAAKYGKVRVAELLLERDAHP 562

Query: 800 DTCSEDQRTPLMEAAENNHLEAVKYLIKAGALVDPKDAEGSTCLHLAAKKGHYEVVQYLL 859
           +   ++  TPL  A  +N+L+ VK L+  G         G T LH+AAK+   EV + LL
Sbjct: 563 NAAGKNGLTPLHVAVHHNNLDIVKLLLPRGGSPHSPAWNGYTPLHIAAKQNQVEVARSLL 622

Query: 860 SNGQMDVNCQDDGGWTPMIWATEYKHVDLVKLLLSKGSDINIRDNEENICLHWAAFSGCV 919
             G    N +   G TP+  A +  H ++V LLLSK ++ N+ +      LH  A  G V
Sbjct: 623 QYGG-SANAESVQGVTPLHLAAQEGHAEMVALLLSKQANGNLGNKSGLTPLHLVAQEGHV 681

Query: 920 DIAEILLAAKCDLHAVNIHGDSPLHIAARENRYDCVVLFLSRDSDVTLKNKEGETPLQCA 979
            +A++L+     + A    G +PLH+A+       V   L   +DV  K K G +PL  A
Sbjct: 682 PVADVLIKHGVMVDATTRMGYTPLHVASHYGNIKLVKFLLQHQADVNAKTKLGYSPLHQA 741

Query: 980 S 980
           +
Sbjct: 742 A 742



 Score =  108 bits (271), Expect = 3e-23
 Identities = 79/264 (29%), Positives = 132/264 (50%), Gaps = 9/264 (3%)

Query: 720 LESALIALDSEKPK----KLRFHPKQLYFSARQGELQKVLLMLVDGIDPNFKMEHQNKRS 775
           +E+ L  L+ E  +    K  F P  L+ +A+ G+++   L+L     PN     +N  +
Sbjct: 516 VETVLALLEKEASQACMTKKGFTP--LHVAAKYGKVRVAELLLERDAHPN--AAGKNGLT 571

Query: 776 PLHAAAEAGHVDICHMLVQAGANIDTCSEDQRTPLMEAAENNHLEAVKYLIKAGALVDPK 835
           PLH A    ++DI  +L+  G +  + + +  TPL  AA+ N +E  + L++ G   + +
Sbjct: 572 PLHVAVHHNNLDIVKLLLPRGGSPHSPAWNGYTPLHIAAKQNQVEVARSLLQYGGSANAE 631

Query: 836 DAEGSTCLHLAAKKGHYEVVQYLLSNGQMDVNCQDDGGWTPMIWATEYKHVDLVKLLLSK 895
             +G T LHLAA++GH E+V  LLS  Q + N  +  G TP+    +  HV +  +L+  
Sbjct: 632 SVQGVTPLHLAAQEGHAEMVALLLSK-QANGNLGNKSGLTPLHLVAQEGHVPVADVLIKH 690

Query: 896 GSDINIRDNEENICLHWAAFSGCVDIAEILLAAKCDLHAVNIHGDSPLHIAARENRYDCV 955
           G  ++         LH A+  G + + + LL  + D++A    G SPLH AA++   D V
Sbjct: 691 GVMVDATTRMGYTPLHVASHYGNIKLVKFLLQHQADVNAKTKLGYSPLHQAAQQGHTDIV 750

Query: 956 VLFLSRDSDVTLKNKEGETPLQCA 979
            L L   +     + +G TPL  A
Sbjct: 751 TLLLKNGASPNEVSSDGTTPLAIA 774



 Score =  106 bits (264), Expect = 2e-22
 Identities = 82/270 (30%), Positives = 132/270 (48%), Gaps = 32/270 (11%)

Query: 745 SARQGELQKVLLMLVDGIDPNFKMEHQNKRSPLHAAAEAGHVDICHMLVQAGANIDTCSE 804
           +AR G L K L  L +G+D N    +QN  + LH A++ GHV +   L+     ++T ++
Sbjct: 19  AARSGNLDKALDHLRNGVDINTC--NQNGLNGLHLASKEGHVKMVVELLHKEIILETTTK 76

Query: 805 DQRTPLMEAAENNHLEAVKYLIKAGALVDPKDAEGSTCLHLAAKKGHYEVVQYLLSNGQM 864
              T L  AA     E V+ L+  GA V+ +  +G T L++AA++ H EVV++LL NG  
Sbjct: 77  KGNTALHIAALAGQDEVVRELVNYGANVNAQSQKGFTPLYMAAQENHLEVVKFLLENG-A 135

Query: 865 DVNCQDDGGWTPMIWATEYKHVDLVKLLLSKGSDINIR--------------------DN 904
           + N   + G+TP+  A +  H ++V  L++ G+   +R                     N
Sbjct: 136 NQNVATEDGFTPLAVALQQGHENVVAHLINYGTKGKVRLPALHIAARNDDTRTAAVLLQN 195

Query: 905 EEN---------ICLHWAAFSGCVDIAEILLAAKCDLHAVNIHGDSPLHIAARENRYDCV 955
           + N           LH AA    +++A++LL     ++    +G +PLHIA+R      V
Sbjct: 196 DPNPDVLSKTGFTPLHIAAHYENLNVAQLLLNRGASVNFTPQNGITPLHIASRRGNVIMV 255

Query: 956 VLFLSRDSDVTLKNKEGETPLQCASLNSQV 985
            L L R + +  K K+  TPL CA+ N  V
Sbjct: 256 RLLLDRGAQIETKTKDELTPLHCAARNGHV 285



 Score =  103 bits (257), Expect = 1e-21
 Identities = 76/245 (31%), Positives = 114/245 (46%), Gaps = 30/245 (12%)

Query: 765 NFKMEHQNKRSPLHAAAEAGHVDICHMLVQAGANIDTCSEDQRTPLMEAAENNHLEAVKY 824
           N   + Q   +PL+ AA+  H+++   L++ GAN +  +ED  TPL  A +  H   V +
Sbjct: 103 NVNAQSQKGFTPLYMAAQENHLEVVKFLLENGANQNVATEDGFTPLAVALQQGHENVVAH 162

Query: 825 LIKAGAL-----------------------------VDPKDAEGSTCLHLAAKKGHYEVV 855
           LI  G                                D     G T LH+AA   +  V 
Sbjct: 163 LINYGTKGKVRLPALHIAARNDDTRTAAVLLQNDPNPDVLSKTGFTPLHIAAHYENLNVA 222

Query: 856 QYLLSNGQMDVNCQDDGGWTPMIWATEYKHVDLVKLLLSKGSDINIRDNEENICLHWAAF 915
           Q LL+ G   VN     G TP+  A+   +V +V+LLL +G+ I  +  +E   LH AA 
Sbjct: 223 QLLLNRGA-SVNFTPQNGITPLHIASRRGNVIMVRLLLDRGAQIETKTKDELTPLHCAAR 281

Query: 916 SGCVDIAEILLAAKCDLHAVNIHGDSPLHIAARENRYDCVVLFLSRDSDVTLKNKEGETP 975
           +G V I+EILL     + A   +G SP+H+AA+ +  DCV L L  D+++     +  TP
Sbjct: 282 NGHVRISEILLDHGAPIQAKTKNGLSPIHMAAQGDHLDCVRLLLQYDAEIDDITLDHLTP 341

Query: 976 LQCAS 980
           L  A+
Sbjct: 342 LHVAA 346



 Score = 95.5 bits (236), Expect = 3e-19
 Identities = 69/207 (33%), Positives = 101/207 (48%), Gaps = 3/207 (1%)

Query: 742 LYFSARQGELQKVLLMLVDGIDPNFKMEHQNKRSPLHAAAEAGHVDICHMLVQAGANIDT 801
           L+ +     L  V L+L  G  P+      N  +PLH AA+   V++   L+Q G + + 
Sbjct: 573 LHVAVHHNNLDIVKLLLPRGGSPHSPA--WNGYTPLHIAAKQNQVEVARSLLQYGGSANA 630

Query: 802 CSEDQRTPLMEAAENNHLEAVKYLIKAGALVDPKDAEGSTCLHLAAKKGHYEVVQYLLSN 861
            S    TPL  AA+  H E V  L+   A  +  +  G T LHL A++GH  V   L+ +
Sbjct: 631 ESVQGVTPLHLAAQEGHAEMVALLLSKQANGNLGNKSGLTPLHLVAQEGHVPVADVLIKH 690

Query: 862 GQMDVNCQDDGGWTPMIWATEYKHVDLVKLLLSKGSDINIRDNEENICLHWAAFSGCVDI 921
           G M V+     G+TP+  A+ Y ++ LVK LL   +D+N +       LH AA  G  DI
Sbjct: 691 GVM-VDATTRMGYTPLHVASHYGNIKLVKFLLQHQADVNAKTKLGYSPLHQAAQQGHTDI 749

Query: 922 AEILLAAKCDLHAVNIHGDSPLHIAAR 948
             +LL      + V+  G +PL IA R
Sbjct: 750 VTLLLKNGASPNEVSSDGTTPLAIAKR 776



 Score = 87.0 bits (214), Expect = 1e-16
 Identities = 56/184 (30%), Positives = 96/184 (52%), Gaps = 3/184 (1%)

Query: 742 LYFSARQGELQKVLLMLVDGIDPNFKMEHQNKRSPLHAAAEAGHVDICHMLVQAGANIDT 801
           L+ +A+Q +++    +L  G   N   E     +PLH AA+ GH ++  +L+   AN + 
Sbjct: 606 LHIAAKQNQVEVARSLLQYGGSAN--AESVQGVTPLHLAAQEGHAEMVALLLSKQANGNL 663

Query: 802 CSEDQRTPLMEAAENNHLEAVKYLIKAGALVDPKDAEGSTCLHLAAKKGHYEVVQYLLSN 861
            ++   TPL   A+  H+     LIK G +VD     G T LH+A+  G+ ++V++LL +
Sbjct: 664 GNKSGLTPLHLVAQEGHVPVADVLIKHGVMVDATTRMGYTPLHVASHYGNIKLVKFLLQH 723

Query: 862 GQMDVNCQDDGGWTPMIWATEYKHVDLVKLLLSKGSDINIRDNEENICLHWAAFSGCVDI 921
            Q DVN +   G++P+  A +  H D+V LLL  G+  N   ++    L  A   G + +
Sbjct: 724 -QADVNAKTKLGYSPLHQAAQQGHTDIVTLLLKNGASPNEVSSDGTTPLAIAKRLGYISV 782

Query: 922 AEIL 925
            ++L
Sbjct: 783 TDVL 786



 Score = 77.0 bits (188), Expect = 1e-13
 Identities = 55/215 (25%), Positives = 105/215 (48%), Gaps = 6/215 (2%)

Query: 692 VPEGFDPTGPAGLGRPTPGLSQGPGKETLESALIALDSEKPKKLRFHPKQLYFSARQGEL 751
           +P G  P  PA  G     ++    +  +  +L+        +       L+ +A++G  
Sbjct: 589 LPRGGSPHSPAWNGYTPLHIAAKQNQVEVARSLLQYGGSANAESVQGVTPLHLAAQEGHA 648

Query: 752 QKVLLMLVDGIDPNFKMEHQNKRSPLHAAAEAGHVDICHMLVQAGANIDTCSEDQRTPLM 811
           + V L+L    + N  + +++  +PLH  A+ GHV +  +L++ G  +D  +    TPL 
Sbjct: 649 EMVALLLSKQANGN--LGNKSGLTPLHLVAQEGHVPVADVLIKHGVMVDATTRMGYTPLH 706

Query: 812 EAAENNHLEAVKYLIKAGALVDPKDAEGSTCLHLAAKKGHYEVVQYLLSNGQMDVNCQDD 871
            A+   +++ VK+L++  A V+ K   G + LH AA++GH ++V  LL NG        D
Sbjct: 707 VASHYGNIKLVKFLLQHQADVNAKTKLGYSPLHQAAQQGHTDIVTLLLKNGASPNEVSSD 766

Query: 872 GGWTPMIWATEYKHV---DLVKLLLSKGSDINIRD 903
            G TP+  A    ++   D++K++  + S + + D
Sbjct: 767 -GTTPLAIAKRLGYISVTDVLKVVTDETSFVLVSD 800



 Score = 64.3 bits (155), Expect = 7e-10
 Identities = 59/242 (24%), Positives = 94/242 (38%), Gaps = 61/242 (25%)

Query: 805 DQRTPLMEAAENNHLEAVKYLIKAGALVDPKDAEGSTCLHLAAKKGHYEVVQYLLS---- 860
           D  T  + AA + +L+     ++ G  ++  +  G   LHLA+K+GH ++V  LL     
Sbjct: 11  DAATSFLRAARSGNLDKALDHLRNGVDINTCNQNGLNGLHLASKEGHVKMVVELLHKEII 70

Query: 861 ----------------------------NGQMDVNCQDDGGWTPMIWATEYKHVDLVKLL 892
                                       N   +VN Q   G+TP+  A +  H+++VK L
Sbjct: 71  LETTTKKGNTALHIAALAGQDEVVRELVNYGANVNAQSQKGFTPLYMAAQENHLEVVKFL 130

Query: 893 LSKGSDINI-------------RDNEENI----------------CLHWAAFSGCVDIAE 923
           L  G++ N+             +   EN+                 LH AA +     A 
Sbjct: 131 LENGANQNVATEDGFTPLAVALQQGHENVVAHLINYGTKGKVRLPALHIAARNDDTRTAA 190

Query: 924 ILLAAKCDLHAVNIHGDSPLHIAARENRYDCVVLFLSRDSDVTLKNKEGETPLQCASLNS 983
           +LL    +   ++  G +PLHIAA     +   L L+R + V    + G TPL  AS   
Sbjct: 191 VLLQNDPNPDVLSKTGFTPLHIAAHYENLNVAQLLLNRGASVNFTPQNGITPLHIASRRG 250

Query: 984 QV 985
            V
Sbjct: 251 NV 252


>gi|70780355 ankyrin 1 isoform 2 [Homo sapiens]
          Length = 1719

 Score =  124 bits (311), Expect = 6e-28
 Identities = 84/256 (32%), Positives = 126/256 (49%), Gaps = 3/256 (1%)

Query: 724 LIALDSEKPKKLRFHPKQLYFSARQGELQKVLLMLVDGIDPNFKMEHQNKRSPLHAAAEA 783
           L+  D+E       H   L+ +A  G  +   ++L  G  PN +    N  +PLH A + 
Sbjct: 324 LLQYDAEIDDITLDHLTPLHVAAHCGHHRVAKVLLDKGAKPNSRA--LNGFTPLHIACKK 381

Query: 784 GHVDICHMLVQAGANIDTCSEDQRTPLMEAAENNHLEAVKYLIKAGALVDPKDAEGSTCL 843
            HV +  +L++ GA+ID  +E   TPL  A+   HL  VK L++ GA  +  + +  T L
Sbjct: 382 NHVRVMELLLKTGASIDAVTESGLTPLHVASFMGHLPIVKNLLQRGASPNVSNVKVETPL 441

Query: 844 HLAAKKGHYEVVQYLLSNGQMDVNCQDDGGWTPMIWATEYKHVDLVKLLLSKGSDINIRD 903
           H+AA+ GH EV +YLL N +  VN +     TP+  A    H ++VKLLL   ++ N+  
Sbjct: 442 HMAARAGHTEVAKYLLQN-KAKVNAKAKDDQTPLHCAARIGHTNMVKLLLENNANPNLAT 500

Query: 904 NEENICLHWAAFSGCVDIAEILLAAKCDLHAVNIHGDSPLHIAARENRYDCVVLFLSRDS 963
              +  LH AA  G V+    LL  +     +   G +PLH+AA+  +     L L RD+
Sbjct: 501 TAGHTPLHIAAREGHVETVLALLEKEASQACMTKKGFTPLHVAAKYGKVRVAELLLERDA 560

Query: 964 DVTLKNKEGETPLQCA 979
                 K G TPL  A
Sbjct: 561 HPNAAGKNGLTPLHVA 576



 Score =  123 bits (309), Expect = 1e-27
 Identities = 81/250 (32%), Positives = 126/250 (50%), Gaps = 3/250 (1%)

Query: 742 LYFSARQGELQKVLLMLVDGIDPNFKMEHQNKRSPLHAAAEAGHVDICHMLVQAGANIDT 801
           L+ +AR G ++   ++L  G     K +  N  SP+H AA+  H+D   +L+Q  A ID 
Sbjct: 276 LHCAARNGHVRISEILLDHGAPIQAKTK--NGLSPIHMAAQGDHLDCVRLLLQYDAEIDD 333

Query: 802 CSEDQRTPLMEAAENNHLEAVKYLIKAGALVDPKDAEGSTCLHLAAKKGHYEVVQYLLSN 861
            + D  TPL  AA   H    K L+  GA  + +   G T LH+A KK H  V++ LL  
Sbjct: 334 ITLDHLTPLHVAAHCGHHRVAKVLLDKGAKPNSRALNGFTPLHIACKKNHVRVMELLLKT 393

Query: 862 GQMDVNCQDDGGWTPMIWATEYKHVDLVKLLLSKGSDINIRDNEENICLHWAAFSGCVDI 921
           G   ++   + G TP+  A+   H+ +VK LL +G+  N+ + +    LH AA +G  ++
Sbjct: 394 G-ASIDAVTESGLTPLHVASFMGHLPIVKNLLQRGASPNVSNVKVETPLHMAARAGHTEV 452

Query: 922 AEILLAAKCDLHAVNIHGDSPLHIAARENRYDCVVLFLSRDSDVTLKNKEGETPLQCASL 981
           A+ LL  K  ++A      +PLH AAR    + V L L  +++  L    G TPL  A+ 
Sbjct: 453 AKYLLQNKAKVNAKAKDDQTPLHCAARIGHTNMVKLLLENNANPNLATTAGHTPLHIAAR 512

Query: 982 NSQVWSALQM 991
              V + L +
Sbjct: 513 EGHVETVLAL 522



 Score =  119 bits (299), Expect = 1e-26
 Identities = 77/239 (32%), Positives = 127/239 (53%), Gaps = 3/239 (1%)

Query: 742 LYFSARQGELQKVLLMLVDGIDPNFKMEHQNKRSPLHAAAEAGHVDICHMLVQAGANIDT 801
           L+ ++R+G +  V L+L  G     K +  ++ +PLH AA  GHV I  +L+  GA I  
Sbjct: 243 LHIASRRGNVIMVRLLLDRGAQIETKTK--DELTPLHCAARNGHVRISEILLDHGAPIQA 300

Query: 802 CSEDQRTPLMEAAENNHLEAVKYLIKAGALVDPKDAEGSTCLHLAAKKGHYEVVQYLLSN 861
            +++  +P+  AA+ +HL+ V+ L++  A +D    +  T LH+AA  GH+ V + LL  
Sbjct: 301 KTKNGLSPIHMAAQGDHLDCVRLLLQYDAEIDDITLDHLTPLHVAAHCGHHRVAKVLLDK 360

Query: 862 GQMDVNCQDDGGWTPMIWATEYKHVDLVKLLLSKGSDINIRDNEENICLHWAAFSGCVDI 921
           G    N +   G+TP+  A +  HV +++LLL  G+ I+         LH A+F G + I
Sbjct: 361 GAKP-NSRALNGFTPLHIACKKNHVRVMELLLKTGASIDAVTESGLTPLHVASFMGHLPI 419

Query: 922 AEILLAAKCDLHAVNIHGDSPLHIAARENRYDCVVLFLSRDSDVTLKNKEGETPLQCAS 980
            + LL      +  N+  ++PLH+AAR    +     L   + V  K K+ +TPL CA+
Sbjct: 420 VKNLLQRGASPNVSNVKVETPLHMAARAGHTEVAKYLLQNKAKVNAKAKDDQTPLHCAA 478



 Score =  112 bits (281), Expect = 2e-24
 Identities = 78/244 (31%), Positives = 120/244 (49%), Gaps = 3/244 (1%)

Query: 742 LYFSARQGELQKVLLMLVDGIDPNFKMEHQNKRSPLHAAAEAGHVDICHMLVQAGANIDT 801
           L+ +AR G  +    +L +    N K +  + ++PLH AA  GH ++  +L++  AN + 
Sbjct: 441 LHMAARAGHTEVAKYLLQNKAKVNAKAK--DDQTPLHCAARIGHTNMVKLLLENNANPNL 498

Query: 802 CSEDQRTPLMEAAENNHLEAVKYLIKAGALVDPKDAEGSTCLHLAAKKGHYEVVQYLLSN 861
            +    TPL  AA   H+E V  L++  A       +G T LH+AAK G   V + LL  
Sbjct: 499 ATTAGHTPLHIAAREGHVETVLALLEKEASQACMTKKGFTPLHVAAKYGKVRVAELLLER 558

Query: 862 GQMDVNCQDDGGWTPMIWATEYKHVDLVKLLLSKGSDINIRDNEENICLHWAAFSGCVDI 921
                N     G TP+  A  + ++D+VKLLL +G   +         LH AA    V++
Sbjct: 559 -DAHPNAAGKNGLTPLHVAVHHNNLDIVKLLLPRGGSPHSPAWNGYTPLHIAAKQNQVEV 617

Query: 922 AEILLAAKCDLHAVNIHGDSPLHIAARENRYDCVVLFLSRDSDVTLKNKEGETPLQCASL 981
           A  LL      +A ++ G +PLH+AA+E   + V L LS+ ++  L NK G TPL   + 
Sbjct: 618 ARSLLQYGGSANAESVQGVTPLHLAAQEGHAEMVALLLSKQANGNLGNKSGLTPLHLVAQ 677

Query: 982 NSQV 985
              V
Sbjct: 678 EGHV 681



 Score =  108 bits (271), Expect = 3e-23
 Identities = 75/241 (31%), Positives = 120/241 (49%), Gaps = 7/241 (2%)

Query: 742 LYFSARQGELQKVLLMLVDGIDPNFKMEHQNKR--SPLHAAAEAGHVDICHMLVQAGANI 799
           L+ +AR+G ++ VL +L    +         K+  +PLH AA+ G V +  +L++  A+ 
Sbjct: 507 LHIAAREGHVETVLALL----EKEASQACMTKKGFTPLHVAAKYGKVRVAELLLERDAHP 562

Query: 800 DTCSEDQRTPLMEAAENNHLEAVKYLIKAGALVDPKDAEGSTCLHLAAKKGHYEVVQYLL 859
           +   ++  TPL  A  +N+L+ VK L+  G         G T LH+AAK+   EV + LL
Sbjct: 563 NAAGKNGLTPLHVAVHHNNLDIVKLLLPRGGSPHSPAWNGYTPLHIAAKQNQVEVARSLL 622

Query: 860 SNGQMDVNCQDDGGWTPMIWATEYKHVDLVKLLLSKGSDINIRDNEENICLHWAAFSGCV 919
             G    N +   G TP+  A +  H ++V LLLSK ++ N+ +      LH  A  G V
Sbjct: 623 QYGG-SANAESVQGVTPLHLAAQEGHAEMVALLLSKQANGNLGNKSGLTPLHLVAQEGHV 681

Query: 920 DIAEILLAAKCDLHAVNIHGDSPLHIAARENRYDCVVLFLSRDSDVTLKNKEGETPLQCA 979
            +A++L+     + A    G +PLH+A+       V   L   +DV  K K G +PL  A
Sbjct: 682 PVADVLIKHGVMVDATTRMGYTPLHVASHYGNIKLVKFLLQHQADVNAKTKLGYSPLHQA 741

Query: 980 S 980
           +
Sbjct: 742 A 742



 Score =  108 bits (271), Expect = 3e-23
 Identities = 79/264 (29%), Positives = 132/264 (50%), Gaps = 9/264 (3%)

Query: 720 LESALIALDSEKPK----KLRFHPKQLYFSARQGELQKVLLMLVDGIDPNFKMEHQNKRS 775
           +E+ L  L+ E  +    K  F P  L+ +A+ G+++   L+L     PN     +N  +
Sbjct: 516 VETVLALLEKEASQACMTKKGFTP--LHVAAKYGKVRVAELLLERDAHPN--AAGKNGLT 571

Query: 776 PLHAAAEAGHVDICHMLVQAGANIDTCSEDQRTPLMEAAENNHLEAVKYLIKAGALVDPK 835
           PLH A    ++DI  +L+  G +  + + +  TPL  AA+ N +E  + L++ G   + +
Sbjct: 572 PLHVAVHHNNLDIVKLLLPRGGSPHSPAWNGYTPLHIAAKQNQVEVARSLLQYGGSANAE 631

Query: 836 DAEGSTCLHLAAKKGHYEVVQYLLSNGQMDVNCQDDGGWTPMIWATEYKHVDLVKLLLSK 895
             +G T LHLAA++GH E+V  LLS  Q + N  +  G TP+    +  HV +  +L+  
Sbjct: 632 SVQGVTPLHLAAQEGHAEMVALLLSK-QANGNLGNKSGLTPLHLVAQEGHVPVADVLIKH 690

Query: 896 GSDINIRDNEENICLHWAAFSGCVDIAEILLAAKCDLHAVNIHGDSPLHIAARENRYDCV 955
           G  ++         LH A+  G + + + LL  + D++A    G SPLH AA++   D V
Sbjct: 691 GVMVDATTRMGYTPLHVASHYGNIKLVKFLLQHQADVNAKTKLGYSPLHQAAQQGHTDIV 750

Query: 956 VLFLSRDSDVTLKNKEGETPLQCA 979
            L L   +     + +G TPL  A
Sbjct: 751 TLLLKNGASPNEVSSDGTTPLAIA 774



 Score =  106 bits (264), Expect = 2e-22
 Identities = 82/270 (30%), Positives = 132/270 (48%), Gaps = 32/270 (11%)

Query: 745 SARQGELQKVLLMLVDGIDPNFKMEHQNKRSPLHAAAEAGHVDICHMLVQAGANIDTCSE 804
           +AR G L K L  L +G+D N    +QN  + LH A++ GHV +   L+     ++T ++
Sbjct: 19  AARSGNLDKALDHLRNGVDINTC--NQNGLNGLHLASKEGHVKMVVELLHKEIILETTTK 76

Query: 805 DQRTPLMEAAENNHLEAVKYLIKAGALVDPKDAEGSTCLHLAAKKGHYEVVQYLLSNGQM 864
              T L  AA     E V+ L+  GA V+ +  +G T L++AA++ H EVV++LL NG  
Sbjct: 77  KGNTALHIAALAGQDEVVRELVNYGANVNAQSQKGFTPLYMAAQENHLEVVKFLLENG-A 135

Query: 865 DVNCQDDGGWTPMIWATEYKHVDLVKLLLSKGSDINIR--------------------DN 904
           + N   + G+TP+  A +  H ++V  L++ G+   +R                     N
Sbjct: 136 NQNVATEDGFTPLAVALQQGHENVVAHLINYGTKGKVRLPALHIAARNDDTRTAAVLLQN 195

Query: 905 EEN---------ICLHWAAFSGCVDIAEILLAAKCDLHAVNIHGDSPLHIAARENRYDCV 955
           + N           LH AA    +++A++LL     ++    +G +PLHIA+R      V
Sbjct: 196 DPNPDVLSKTGFTPLHIAAHYENLNVAQLLLNRGASVNFTPQNGITPLHIASRRGNVIMV 255

Query: 956 VLFLSRDSDVTLKNKEGETPLQCASLNSQV 985
            L L R + +  K K+  TPL CA+ N  V
Sbjct: 256 RLLLDRGAQIETKTKDELTPLHCAARNGHV 285



 Score =  103 bits (257), Expect = 1e-21
 Identities = 76/245 (31%), Positives = 114/245 (46%), Gaps = 30/245 (12%)

Query: 765 NFKMEHQNKRSPLHAAAEAGHVDICHMLVQAGANIDTCSEDQRTPLMEAAENNHLEAVKY 824
           N   + Q   +PL+ AA+  H+++   L++ GAN +  +ED  TPL  A +  H   V +
Sbjct: 103 NVNAQSQKGFTPLYMAAQENHLEVVKFLLENGANQNVATEDGFTPLAVALQQGHENVVAH 162

Query: 825 LIKAGAL-----------------------------VDPKDAEGSTCLHLAAKKGHYEVV 855
           LI  G                                D     G T LH+AA   +  V 
Sbjct: 163 LINYGTKGKVRLPALHIAARNDDTRTAAVLLQNDPNPDVLSKTGFTPLHIAAHYENLNVA 222

Query: 856 QYLLSNGQMDVNCQDDGGWTPMIWATEYKHVDLVKLLLSKGSDINIRDNEENICLHWAAF 915
           Q LL+ G   VN     G TP+  A+   +V +V+LLL +G+ I  +  +E   LH AA 
Sbjct: 223 QLLLNRGA-SVNFTPQNGITPLHIASRRGNVIMVRLLLDRGAQIETKTKDELTPLHCAAR 281

Query: 916 SGCVDIAEILLAAKCDLHAVNIHGDSPLHIAARENRYDCVVLFLSRDSDVTLKNKEGETP 975
           +G V I+EILL     + A   +G SP+H+AA+ +  DCV L L  D+++     +  TP
Sbjct: 282 NGHVRISEILLDHGAPIQAKTKNGLSPIHMAAQGDHLDCVRLLLQYDAEIDDITLDHLTP 341

Query: 976 LQCAS 980
           L  A+
Sbjct: 342 LHVAA 346



 Score = 95.5 bits (236), Expect = 3e-19
 Identities = 69/207 (33%), Positives = 101/207 (48%), Gaps = 3/207 (1%)

Query: 742 LYFSARQGELQKVLLMLVDGIDPNFKMEHQNKRSPLHAAAEAGHVDICHMLVQAGANIDT 801
           L+ +     L  V L+L  G  P+      N  +PLH AA+   V++   L+Q G + + 
Sbjct: 573 LHVAVHHNNLDIVKLLLPRGGSPHSPA--WNGYTPLHIAAKQNQVEVARSLLQYGGSANA 630

Query: 802 CSEDQRTPLMEAAENNHLEAVKYLIKAGALVDPKDAEGSTCLHLAAKKGHYEVVQYLLSN 861
            S    TPL  AA+  H E V  L+   A  +  +  G T LHL A++GH  V   L+ +
Sbjct: 631 ESVQGVTPLHLAAQEGHAEMVALLLSKQANGNLGNKSGLTPLHLVAQEGHVPVADVLIKH 690

Query: 862 GQMDVNCQDDGGWTPMIWATEYKHVDLVKLLLSKGSDINIRDNEENICLHWAAFSGCVDI 921
           G M V+     G+TP+  A+ Y ++ LVK LL   +D+N +       LH AA  G  DI
Sbjct: 691 GVM-VDATTRMGYTPLHVASHYGNIKLVKFLLQHQADVNAKTKLGYSPLHQAAQQGHTDI 749

Query: 922 AEILLAAKCDLHAVNIHGDSPLHIAAR 948
             +LL      + V+  G +PL IA R
Sbjct: 750 VTLLLKNGASPNEVSSDGTTPLAIAKR 776



 Score = 87.0 bits (214), Expect = 1e-16
 Identities = 56/184 (30%), Positives = 96/184 (52%), Gaps = 3/184 (1%)

Query: 742 LYFSARQGELQKVLLMLVDGIDPNFKMEHQNKRSPLHAAAEAGHVDICHMLVQAGANIDT 801
           L+ +A+Q +++    +L  G   N   E     +PLH AA+ GH ++  +L+   AN + 
Sbjct: 606 LHIAAKQNQVEVARSLLQYGGSAN--AESVQGVTPLHLAAQEGHAEMVALLLSKQANGNL 663

Query: 802 CSEDQRTPLMEAAENNHLEAVKYLIKAGALVDPKDAEGSTCLHLAAKKGHYEVVQYLLSN 861
            ++   TPL   A+  H+     LIK G +VD     G T LH+A+  G+ ++V++LL +
Sbjct: 664 GNKSGLTPLHLVAQEGHVPVADVLIKHGVMVDATTRMGYTPLHVASHYGNIKLVKFLLQH 723

Query: 862 GQMDVNCQDDGGWTPMIWATEYKHVDLVKLLLSKGSDINIRDNEENICLHWAAFSGCVDI 921
            Q DVN +   G++P+  A +  H D+V LLL  G+  N   ++    L  A   G + +
Sbjct: 724 -QADVNAKTKLGYSPLHQAAQQGHTDIVTLLLKNGASPNEVSSDGTTPLAIAKRLGYISV 782

Query: 922 AEIL 925
            ++L
Sbjct: 783 TDVL 786



 Score = 77.0 bits (188), Expect = 1e-13
 Identities = 55/215 (25%), Positives = 105/215 (48%), Gaps = 6/215 (2%)

Query: 692 VPEGFDPTGPAGLGRPTPGLSQGPGKETLESALIALDSEKPKKLRFHPKQLYFSARQGEL 751
           +P G  P  PA  G     ++    +  +  +L+        +       L+ +A++G  
Sbjct: 589 LPRGGSPHSPAWNGYTPLHIAAKQNQVEVARSLLQYGGSANAESVQGVTPLHLAAQEGHA 648

Query: 752 QKVLLMLVDGIDPNFKMEHQNKRSPLHAAAEAGHVDICHMLVQAGANIDTCSEDQRTPLM 811
           + V L+L    + N  + +++  +PLH  A+ GHV +  +L++ G  +D  +    TPL 
Sbjct: 649 EMVALLLSKQANGN--LGNKSGLTPLHLVAQEGHVPVADVLIKHGVMVDATTRMGYTPLH 706

Query: 812 EAAENNHLEAVKYLIKAGALVDPKDAEGSTCLHLAAKKGHYEVVQYLLSNGQMDVNCQDD 871
            A+   +++ VK+L++  A V+ K   G + LH AA++GH ++V  LL NG        D
Sbjct: 707 VASHYGNIKLVKFLLQHQADVNAKTKLGYSPLHQAAQQGHTDIVTLLLKNGASPNEVSSD 766

Query: 872 GGWTPMIWATEYKHV---DLVKLLLSKGSDINIRD 903
            G TP+  A    ++   D++K++  + S + + D
Sbjct: 767 -GTTPLAIAKRLGYISVTDVLKVVTDETSFVLVSD 800



 Score = 64.3 bits (155), Expect = 7e-10
 Identities = 59/242 (24%), Positives = 94/242 (38%), Gaps = 61/242 (25%)

Query: 805 DQRTPLMEAAENNHLEAVKYLIKAGALVDPKDAEGSTCLHLAAKKGHYEVVQYLLS---- 860
           D  T  + AA + +L+     ++ G  ++  +  G   LHLA+K+GH ++V  LL     
Sbjct: 11  DAATSFLRAARSGNLDKALDHLRNGVDINTCNQNGLNGLHLASKEGHVKMVVELLHKEII 70

Query: 861 ----------------------------NGQMDVNCQDDGGWTPMIWATEYKHVDLVKLL 892
                                       N   +VN Q   G+TP+  A +  H+++VK L
Sbjct: 71  LETTTKKGNTALHIAALAGQDEVVRELVNYGANVNAQSQKGFTPLYMAAQENHLEVVKFL 130

Query: 893 LSKGSDINI-------------RDNEENI----------------CLHWAAFSGCVDIAE 923
           L  G++ N+             +   EN+                 LH AA +     A 
Sbjct: 131 LENGANQNVATEDGFTPLAVALQQGHENVVAHLINYGTKGKVRLPALHIAARNDDTRTAA 190

Query: 924 ILLAAKCDLHAVNIHGDSPLHIAARENRYDCVVLFLSRDSDVTLKNKEGETPLQCASLNS 983
           +LL    +   ++  G +PLHIAA     +   L L+R + V    + G TPL  AS   
Sbjct: 191 VLLQNDPNPDVLSKTGFTPLHIAAHYENLNVAQLLLNRGASVNFTPQNGITPLHIASRRG 250

Query: 984 QV 985
            V
Sbjct: 251 NV 252


>gi|70780353 ankyrin 1 isoform 4 [Homo sapiens]
          Length = 1856

 Score =  124 bits (311), Expect = 6e-28
 Identities = 84/256 (32%), Positives = 126/256 (49%), Gaps = 3/256 (1%)

Query: 724 LIALDSEKPKKLRFHPKQLYFSARQGELQKVLLMLVDGIDPNFKMEHQNKRSPLHAAAEA 783
           L+  D+E       H   L+ +A  G  +   ++L  G  PN +    N  +PLH A + 
Sbjct: 324 LLQYDAEIDDITLDHLTPLHVAAHCGHHRVAKVLLDKGAKPNSRA--LNGFTPLHIACKK 381

Query: 784 GHVDICHMLVQAGANIDTCSEDQRTPLMEAAENNHLEAVKYLIKAGALVDPKDAEGSTCL 843
            HV +  +L++ GA+ID  +E   TPL  A+   HL  VK L++ GA  +  + +  T L
Sbjct: 382 NHVRVMELLLKTGASIDAVTESGLTPLHVASFMGHLPIVKNLLQRGASPNVSNVKVETPL 441

Query: 844 HLAAKKGHYEVVQYLLSNGQMDVNCQDDGGWTPMIWATEYKHVDLVKLLLSKGSDINIRD 903
           H+AA+ GH EV +YLL N +  VN +     TP+  A    H ++VKLLL   ++ N+  
Sbjct: 442 HMAARAGHTEVAKYLLQN-KAKVNAKAKDDQTPLHCAARIGHTNMVKLLLENNANPNLAT 500

Query: 904 NEENICLHWAAFSGCVDIAEILLAAKCDLHAVNIHGDSPLHIAARENRYDCVVLFLSRDS 963
              +  LH AA  G V+    LL  +     +   G +PLH+AA+  +     L L RD+
Sbjct: 501 TAGHTPLHIAAREGHVETVLALLEKEASQACMTKKGFTPLHVAAKYGKVRVAELLLERDA 560

Query: 964 DVTLKNKEGETPLQCA 979
                 K G TPL  A
Sbjct: 561 HPNAAGKNGLTPLHVA 576



 Score =  123 bits (309), Expect = 1e-27
 Identities = 81/250 (32%), Positives = 126/250 (50%), Gaps = 3/250 (1%)

Query: 742 LYFSARQGELQKVLLMLVDGIDPNFKMEHQNKRSPLHAAAEAGHVDICHMLVQAGANIDT 801
           L+ +AR G ++   ++L  G     K +  N  SP+H AA+  H+D   +L+Q  A ID 
Sbjct: 276 LHCAARNGHVRISEILLDHGAPIQAKTK--NGLSPIHMAAQGDHLDCVRLLLQYDAEIDD 333

Query: 802 CSEDQRTPLMEAAENNHLEAVKYLIKAGALVDPKDAEGSTCLHLAAKKGHYEVVQYLLSN 861
            + D  TPL  AA   H    K L+  GA  + +   G T LH+A KK H  V++ LL  
Sbjct: 334 ITLDHLTPLHVAAHCGHHRVAKVLLDKGAKPNSRALNGFTPLHIACKKNHVRVMELLLKT 393

Query: 862 GQMDVNCQDDGGWTPMIWATEYKHVDLVKLLLSKGSDINIRDNEENICLHWAAFSGCVDI 921
           G   ++   + G TP+  A+   H+ +VK LL +G+  N+ + +    LH AA +G  ++
Sbjct: 394 G-ASIDAVTESGLTPLHVASFMGHLPIVKNLLQRGASPNVSNVKVETPLHMAARAGHTEV 452

Query: 922 AEILLAAKCDLHAVNIHGDSPLHIAARENRYDCVVLFLSRDSDVTLKNKEGETPLQCASL 981
           A+ LL  K  ++A      +PLH AAR    + V L L  +++  L    G TPL  A+ 
Sbjct: 453 AKYLLQNKAKVNAKAKDDQTPLHCAARIGHTNMVKLLLENNANPNLATTAGHTPLHIAAR 512

Query: 982 NSQVWSALQM 991
              V + L +
Sbjct: 513 EGHVETVLAL 522



 Score =  119 bits (299), Expect = 1e-26
 Identities = 77/239 (32%), Positives = 127/239 (53%), Gaps = 3/239 (1%)

Query: 742 LYFSARQGELQKVLLMLVDGIDPNFKMEHQNKRSPLHAAAEAGHVDICHMLVQAGANIDT 801
           L+ ++R+G +  V L+L  G     K +  ++ +PLH AA  GHV I  +L+  GA I  
Sbjct: 243 LHIASRRGNVIMVRLLLDRGAQIETKTK--DELTPLHCAARNGHVRISEILLDHGAPIQA 300

Query: 802 CSEDQRTPLMEAAENNHLEAVKYLIKAGALVDPKDAEGSTCLHLAAKKGHYEVVQYLLSN 861
            +++  +P+  AA+ +HL+ V+ L++  A +D    +  T LH+AA  GH+ V + LL  
Sbjct: 301 KTKNGLSPIHMAAQGDHLDCVRLLLQYDAEIDDITLDHLTPLHVAAHCGHHRVAKVLLDK 360

Query: 862 GQMDVNCQDDGGWTPMIWATEYKHVDLVKLLLSKGSDINIRDNEENICLHWAAFSGCVDI 921
           G    N +   G+TP+  A +  HV +++LLL  G+ I+         LH A+F G + I
Sbjct: 361 GAKP-NSRALNGFTPLHIACKKNHVRVMELLLKTGASIDAVTESGLTPLHVASFMGHLPI 419

Query: 922 AEILLAAKCDLHAVNIHGDSPLHIAARENRYDCVVLFLSRDSDVTLKNKEGETPLQCAS 980
            + LL      +  N+  ++PLH+AAR    +     L   + V  K K+ +TPL CA+
Sbjct: 420 VKNLLQRGASPNVSNVKVETPLHMAARAGHTEVAKYLLQNKAKVNAKAKDDQTPLHCAA 478



 Score =  112 bits (281), Expect = 2e-24
 Identities = 78/244 (31%), Positives = 120/244 (49%), Gaps = 3/244 (1%)

Query: 742 LYFSARQGELQKVLLMLVDGIDPNFKMEHQNKRSPLHAAAEAGHVDICHMLVQAGANIDT 801
           L+ +AR G  +    +L +    N K +  + ++PLH AA  GH ++  +L++  AN + 
Sbjct: 441 LHMAARAGHTEVAKYLLQNKAKVNAKAK--DDQTPLHCAARIGHTNMVKLLLENNANPNL 498

Query: 802 CSEDQRTPLMEAAENNHLEAVKYLIKAGALVDPKDAEGSTCLHLAAKKGHYEVVQYLLSN 861
            +    TPL  AA   H+E V  L++  A       +G T LH+AAK G   V + LL  
Sbjct: 499 ATTAGHTPLHIAAREGHVETVLALLEKEASQACMTKKGFTPLHVAAKYGKVRVAELLLER 558

Query: 862 GQMDVNCQDDGGWTPMIWATEYKHVDLVKLLLSKGSDINIRDNEENICLHWAAFSGCVDI 921
                N     G TP+  A  + ++D+VKLLL +G   +         LH AA    V++
Sbjct: 559 -DAHPNAAGKNGLTPLHVAVHHNNLDIVKLLLPRGGSPHSPAWNGYTPLHIAAKQNQVEV 617

Query: 922 AEILLAAKCDLHAVNIHGDSPLHIAARENRYDCVVLFLSRDSDVTLKNKEGETPLQCASL 981
           A  LL      +A ++ G +PLH+AA+E   + V L LS+ ++  L NK G TPL   + 
Sbjct: 618 ARSLLQYGGSANAESVQGVTPLHLAAQEGHAEMVALLLSKQANGNLGNKSGLTPLHLVAQ 677

Query: 982 NSQV 985
              V
Sbjct: 678 EGHV 681



 Score =  108 bits (271), Expect = 3e-23
 Identities = 75/241 (31%), Positives = 120/241 (49%), Gaps = 7/241 (2%)

Query: 742 LYFSARQGELQKVLLMLVDGIDPNFKMEHQNKR--SPLHAAAEAGHVDICHMLVQAGANI 799
           L+ +AR+G ++ VL +L    +         K+  +PLH AA+ G V +  +L++  A+ 
Sbjct: 507 LHIAAREGHVETVLALL----EKEASQACMTKKGFTPLHVAAKYGKVRVAELLLERDAHP 562

Query: 800 DTCSEDQRTPLMEAAENNHLEAVKYLIKAGALVDPKDAEGSTCLHLAAKKGHYEVVQYLL 859
           +   ++  TPL  A  +N+L+ VK L+  G         G T LH+AAK+   EV + LL
Sbjct: 563 NAAGKNGLTPLHVAVHHNNLDIVKLLLPRGGSPHSPAWNGYTPLHIAAKQNQVEVARSLL 622

Query: 860 SNGQMDVNCQDDGGWTPMIWATEYKHVDLVKLLLSKGSDINIRDNEENICLHWAAFSGCV 919
             G    N +   G TP+  A +  H ++V LLLSK ++ N+ +      LH  A  G V
Sbjct: 623 QYGG-SANAESVQGVTPLHLAAQEGHAEMVALLLSKQANGNLGNKSGLTPLHLVAQEGHV 681

Query: 920 DIAEILLAAKCDLHAVNIHGDSPLHIAARENRYDCVVLFLSRDSDVTLKNKEGETPLQCA 979
            +A++L+     + A    G +PLH+A+       V   L   +DV  K K G +PL  A
Sbjct: 682 PVADVLIKHGVMVDATTRMGYTPLHVASHYGNIKLVKFLLQHQADVNAKTKLGYSPLHQA 741

Query: 980 S 980
           +
Sbjct: 742 A 742



 Score =  108 bits (271), Expect = 3e-23
 Identities = 79/264 (29%), Positives = 132/264 (50%), Gaps = 9/264 (3%)

Query: 720 LESALIALDSEKPK----KLRFHPKQLYFSARQGELQKVLLMLVDGIDPNFKMEHQNKRS 775
           +E+ L  L+ E  +    K  F P  L+ +A+ G+++   L+L     PN     +N  +
Sbjct: 516 VETVLALLEKEASQACMTKKGFTP--LHVAAKYGKVRVAELLLERDAHPN--AAGKNGLT 571

Query: 776 PLHAAAEAGHVDICHMLVQAGANIDTCSEDQRTPLMEAAENNHLEAVKYLIKAGALVDPK 835
           PLH A    ++DI  +L+  G +  + + +  TPL  AA+ N +E  + L++ G   + +
Sbjct: 572 PLHVAVHHNNLDIVKLLLPRGGSPHSPAWNGYTPLHIAAKQNQVEVARSLLQYGGSANAE 631

Query: 836 DAEGSTCLHLAAKKGHYEVVQYLLSNGQMDVNCQDDGGWTPMIWATEYKHVDLVKLLLSK 895
             +G T LHLAA++GH E+V  LLS  Q + N  +  G TP+    +  HV +  +L+  
Sbjct: 632 SVQGVTPLHLAAQEGHAEMVALLLSK-QANGNLGNKSGLTPLHLVAQEGHVPVADVLIKH 690

Query: 896 GSDINIRDNEENICLHWAAFSGCVDIAEILLAAKCDLHAVNIHGDSPLHIAARENRYDCV 955
           G  ++         LH A+  G + + + LL  + D++A    G SPLH AA++   D V
Sbjct: 691 GVMVDATTRMGYTPLHVASHYGNIKLVKFLLQHQADVNAKTKLGYSPLHQAAQQGHTDIV 750

Query: 956 VLFLSRDSDVTLKNKEGETPLQCA 979
            L L   +     + +G TPL  A
Sbjct: 751 TLLLKNGASPNEVSSDGTTPLAIA 774



 Score =  106 bits (264), Expect = 2e-22
 Identities = 82/270 (30%), Positives = 132/270 (48%), Gaps = 32/270 (11%)

Query: 745 SARQGELQKVLLMLVDGIDPNFKMEHQNKRSPLHAAAEAGHVDICHMLVQAGANIDTCSE 804
           +AR G L K L  L +G+D N    +QN  + LH A++ GHV +   L+     ++T ++
Sbjct: 19  AARSGNLDKALDHLRNGVDINTC--NQNGLNGLHLASKEGHVKMVVELLHKEIILETTTK 76

Query: 805 DQRTPLMEAAENNHLEAVKYLIKAGALVDPKDAEGSTCLHLAAKKGHYEVVQYLLSNGQM 864
              T L  AA     E V+ L+  GA V+ +  +G T L++AA++ H EVV++LL NG  
Sbjct: 77  KGNTALHIAALAGQDEVVRELVNYGANVNAQSQKGFTPLYMAAQENHLEVVKFLLENG-A 135

Query: 865 DVNCQDDGGWTPMIWATEYKHVDLVKLLLSKGSDINIR--------------------DN 904
           + N   + G+TP+  A +  H ++V  L++ G+   +R                     N
Sbjct: 136 NQNVATEDGFTPLAVALQQGHENVVAHLINYGTKGKVRLPALHIAARNDDTRTAAVLLQN 195

Query: 905 EEN---------ICLHWAAFSGCVDIAEILLAAKCDLHAVNIHGDSPLHIAARENRYDCV 955
           + N           LH AA    +++A++LL     ++    +G +PLHIA+R      V
Sbjct: 196 DPNPDVLSKTGFTPLHIAAHYENLNVAQLLLNRGASVNFTPQNGITPLHIASRRGNVIMV 255

Query: 956 VLFLSRDSDVTLKNKEGETPLQCASLNSQV 985
            L L R + +  K K+  TPL CA+ N  V
Sbjct: 256 RLLLDRGAQIETKTKDELTPLHCAARNGHV 285



 Score =  103 bits (257), Expect = 1e-21
 Identities = 76/245 (31%), Positives = 114/245 (46%), Gaps = 30/245 (12%)

Query: 765 NFKMEHQNKRSPLHAAAEAGHVDICHMLVQAGANIDTCSEDQRTPLMEAAENNHLEAVKY 824
           N   + Q   +PL+ AA+  H+++   L++ GAN +  +ED  TPL  A +  H   V +
Sbjct: 103 NVNAQSQKGFTPLYMAAQENHLEVVKFLLENGANQNVATEDGFTPLAVALQQGHENVVAH 162

Query: 825 LIKAGAL-----------------------------VDPKDAEGSTCLHLAAKKGHYEVV 855
           LI  G                                D     G T LH+AA   +  V 
Sbjct: 163 LINYGTKGKVRLPALHIAARNDDTRTAAVLLQNDPNPDVLSKTGFTPLHIAAHYENLNVA 222

Query: 856 QYLLSNGQMDVNCQDDGGWTPMIWATEYKHVDLVKLLLSKGSDINIRDNEENICLHWAAF 915
           Q LL+ G   VN     G TP+  A+   +V +V+LLL +G+ I  +  +E   LH AA 
Sbjct: 223 QLLLNRGA-SVNFTPQNGITPLHIASRRGNVIMVRLLLDRGAQIETKTKDELTPLHCAAR 281

Query: 916 SGCVDIAEILLAAKCDLHAVNIHGDSPLHIAARENRYDCVVLFLSRDSDVTLKNKEGETP 975
           +G V I+EILL     + A   +G SP+H+AA+ +  DCV L L  D+++     +  TP
Sbjct: 282 NGHVRISEILLDHGAPIQAKTKNGLSPIHMAAQGDHLDCVRLLLQYDAEIDDITLDHLTP 341

Query: 976 LQCAS 980
           L  A+
Sbjct: 342 LHVAA 346



 Score = 95.5 bits (236), Expect = 3e-19
 Identities = 69/207 (33%), Positives = 101/207 (48%), Gaps = 3/207 (1%)

Query: 742 LYFSARQGELQKVLLMLVDGIDPNFKMEHQNKRSPLHAAAEAGHVDICHMLVQAGANIDT 801
           L+ +     L  V L+L  G  P+      N  +PLH AA+   V++   L+Q G + + 
Sbjct: 573 LHVAVHHNNLDIVKLLLPRGGSPHSPA--WNGYTPLHIAAKQNQVEVARSLLQYGGSANA 630

Query: 802 CSEDQRTPLMEAAENNHLEAVKYLIKAGALVDPKDAEGSTCLHLAAKKGHYEVVQYLLSN 861
            S    TPL  AA+  H E V  L+   A  +  +  G T LHL A++GH  V   L+ +
Sbjct: 631 ESVQGVTPLHLAAQEGHAEMVALLLSKQANGNLGNKSGLTPLHLVAQEGHVPVADVLIKH 690

Query: 862 GQMDVNCQDDGGWTPMIWATEYKHVDLVKLLLSKGSDINIRDNEENICLHWAAFSGCVDI 921
           G M V+     G+TP+  A+ Y ++ LVK LL   +D+N +       LH AA  G  DI
Sbjct: 691 GVM-VDATTRMGYTPLHVASHYGNIKLVKFLLQHQADVNAKTKLGYSPLHQAAQQGHTDI 749

Query: 922 AEILLAAKCDLHAVNIHGDSPLHIAAR 948
             +LL      + V+  G +PL IA R
Sbjct: 750 VTLLLKNGASPNEVSSDGTTPLAIAKR 776



 Score = 87.0 bits (214), Expect = 1e-16
 Identities = 56/184 (30%), Positives = 96/184 (52%), Gaps = 3/184 (1%)

Query: 742 LYFSARQGELQKVLLMLVDGIDPNFKMEHQNKRSPLHAAAEAGHVDICHMLVQAGANIDT 801
           L+ +A+Q +++    +L  G   N   E     +PLH AA+ GH ++  +L+   AN + 
Sbjct: 606 LHIAAKQNQVEVARSLLQYGGSAN--AESVQGVTPLHLAAQEGHAEMVALLLSKQANGNL 663

Query: 802 CSEDQRTPLMEAAENNHLEAVKYLIKAGALVDPKDAEGSTCLHLAAKKGHYEVVQYLLSN 861
            ++   TPL   A+  H+     LIK G +VD     G T LH+A+  G+ ++V++LL +
Sbjct: 664 GNKSGLTPLHLVAQEGHVPVADVLIKHGVMVDATTRMGYTPLHVASHYGNIKLVKFLLQH 723

Query: 862 GQMDVNCQDDGGWTPMIWATEYKHVDLVKLLLSKGSDINIRDNEENICLHWAAFSGCVDI 921
            Q DVN +   G++P+  A +  H D+V LLL  G+  N   ++    L  A   G + +
Sbjct: 724 -QADVNAKTKLGYSPLHQAAQQGHTDIVTLLLKNGASPNEVSSDGTTPLAIAKRLGYISV 782

Query: 922 AEIL 925
            ++L
Sbjct: 783 TDVL 786



 Score = 77.0 bits (188), Expect = 1e-13
 Identities = 55/215 (25%), Positives = 105/215 (48%), Gaps = 6/215 (2%)

Query: 692 VPEGFDPTGPAGLGRPTPGLSQGPGKETLESALIALDSEKPKKLRFHPKQLYFSARQGEL 751
           +P G  P  PA  G     ++    +  +  +L+        +       L+ +A++G  
Sbjct: 589 LPRGGSPHSPAWNGYTPLHIAAKQNQVEVARSLLQYGGSANAESVQGVTPLHLAAQEGHA 648

Query: 752 QKVLLMLVDGIDPNFKMEHQNKRSPLHAAAEAGHVDICHMLVQAGANIDTCSEDQRTPLM 811
           + V L+L    + N  + +++  +PLH  A+ GHV +  +L++ G  +D  +    TPL 
Sbjct: 649 EMVALLLSKQANGN--LGNKSGLTPLHLVAQEGHVPVADVLIKHGVMVDATTRMGYTPLH 706

Query: 812 EAAENNHLEAVKYLIKAGALVDPKDAEGSTCLHLAAKKGHYEVVQYLLSNGQMDVNCQDD 871
            A+   +++ VK+L++  A V+ K   G + LH AA++GH ++V  LL NG        D
Sbjct: 707 VASHYGNIKLVKFLLQHQADVNAKTKLGYSPLHQAAQQGHTDIVTLLLKNGASPNEVSSD 766

Query: 872 GGWTPMIWATEYKHV---DLVKLLLSKGSDINIRD 903
            G TP+  A    ++   D++K++  + S + + D
Sbjct: 767 -GTTPLAIAKRLGYISVTDVLKVVTDETSFVLVSD 800



 Score = 64.3 bits (155), Expect = 7e-10
 Identities = 59/242 (24%), Positives = 94/242 (38%), Gaps = 61/242 (25%)

Query: 805 DQRTPLMEAAENNHLEAVKYLIKAGALVDPKDAEGSTCLHLAAKKGHYEVVQYLLS---- 860
           D  T  + AA + +L+     ++ G  ++  +  G   LHLA+K+GH ++V  LL     
Sbjct: 11  DAATSFLRAARSGNLDKALDHLRNGVDINTCNQNGLNGLHLASKEGHVKMVVELLHKEII 70

Query: 861 ----------------------------NGQMDVNCQDDGGWTPMIWATEYKHVDLVKLL 892
                                       N   +VN Q   G+TP+  A +  H+++VK L
Sbjct: 71  LETTTKKGNTALHIAALAGQDEVVRELVNYGANVNAQSQKGFTPLYMAAQENHLEVVKFL 130

Query: 893 LSKGSDINI-------------RDNEENI----------------CLHWAAFSGCVDIAE 923
           L  G++ N+             +   EN+                 LH AA +     A 
Sbjct: 131 LENGANQNVATEDGFTPLAVALQQGHENVVAHLINYGTKGKVRLPALHIAARNDDTRTAA 190

Query: 924 ILLAAKCDLHAVNIHGDSPLHIAARENRYDCVVLFLSRDSDVTLKNKEGETPLQCASLNS 983
           +LL    +   ++  G +PLHIAA     +   L L+R + V    + G TPL  AS   
Sbjct: 191 VLLQNDPNPDVLSKTGFTPLHIAAHYENLNVAQLLLNRGASVNFTPQNGITPLHIASRRG 250

Query: 984 QV 985
            V
Sbjct: 251 NV 252


>gi|32967601 ankyrin 3 isoform 1 [Homo sapiens]
          Length = 4377

 Score =  124 bits (311), Expect = 6e-28
 Identities = 77/262 (29%), Positives = 137/262 (52%), Gaps = 3/262 (1%)

Query: 724 LIALDSEKPKKLRFHPKQLYFSARQGELQKVLLMLVDGIDPNFKMEHQNKRSPLHAAAEA 783
           +++L  E   K +     L+ +AR+ + +   L+L +  D N  +E ++  +PLH AA  
Sbjct: 188 VVSLLLENDTKGKVRLPALHIAARKDDTKAAALLLQN--DNNADVESKSGFTPLHIAAHY 245

Query: 784 GHVDICHMLVQAGANIDTCSEDQRTPLMEAAENNHLEAVKYLIKAGALVDPKDAEGSTCL 843
           G++++  +L+   A +D  + +  TPL  A++  +   VK L+  GA +D K  +G T L
Sbjct: 246 GNINVATLLLNRAAAVDFTARNDITPLHVASKRGNANMVKLLLDRGAKIDAKTRDGLTPL 305

Query: 844 HLAAKKGHYEVVQYLLSNGQMDVNCQDDGGWTPMIWATEYKHVDLVKLLLSKGSDINIRD 903
           H  A+ GH +VV+ LL      +  +   G +P+  AT+  H++ V+LLL     ++   
Sbjct: 306 HCGARSGHEQVVEMLLDRA-APILSKTKNGLSPLHMATQGDHLNCVQLLLQHNVPVDDVT 364

Query: 904 NEENICLHWAAFSGCVDIAEILLAAKCDLHAVNIHGDSPLHIAARENRYDCVVLFLSRDS 963
           N+    LH AA  G   +A++LL  K + +A  ++G +PLHIA ++NR   + L L   +
Sbjct: 365 NDYLTALHVAAHCGHYKVAKVLLDKKANPNAKALNGFTPLHIACKKNRIKVMELLLKHGA 424

Query: 964 DVTLKNKEGETPLQCASLNSQV 985
            +    + G TP+  A+    V
Sbjct: 425 SIQAVTESGLTPIHVAAFMGHV 446



 Score =  119 bits (299), Expect = 1e-26
 Identities = 80/244 (32%), Positives = 120/244 (49%), Gaps = 3/244 (1%)

Query: 742 LYFSARQGELQKVLLMLVDGIDPNFKMEHQNKRSPLHAAAEAGHVDICHMLVQAGANIDT 801
           L+ +AR G+ + V  ++ DG     K +  + ++PLH +A  G  DI   L+Q GA+ + 
Sbjct: 470 LHMAARSGQAEVVRYLVQDGAQVEAKAK--DDQTPLHISARLGKADIVQQLLQQGASPNA 527

Query: 802 CSEDQRTPLMEAAENNHLEAVKYLIKAGALVDPKDAEGSTCLHLAAKKGHYEVVQYLLSN 861
            +    TPL  +A   H +   +L+  GA +     +G T LH+AAK G  EV   LL  
Sbjct: 528 ATTSGYTPLHLSAREGHEDVAAFLLDHGASLSITTKKGFTPLHVAAKYGKLEVANLLLQK 587

Query: 862 GQMDVNCQDDGGWTPMIWATEYKHVDLVKLLLSKGSDINIRDNEENICLHWAAFSGCVDI 921
                +     G TP+  A  Y +  +  LLL +G+  +         LH AA    +DI
Sbjct: 588 SASP-DAAGKSGLTPLHVAAHYDNQKVALLLLDQGASPHAAAKNGYTPLHIAAKKNQMDI 646

Query: 922 AEILLAAKCDLHAVNIHGDSPLHIAARENRYDCVVLFLSRDSDVTLKNKEGETPLQCASL 981
           A  LL    D +AV   G + +H+AA+E   D V L L R+++V L NK G TPL  A+ 
Sbjct: 647 ATTLLEYGADANAVTRQGIASVHLAAQEGHVDMVSLLLGRNANVNLSNKSGLTPLHLAAQ 706

Query: 982 NSQV 985
             +V
Sbjct: 707 EDRV 710



 Score =  117 bits (294), Expect = 5e-26
 Identities = 91/295 (30%), Positives = 142/295 (48%), Gaps = 49/295 (16%)

Query: 730 EKPKKLRFHPKQ-------------LYFSARQGELQKVLLMLVDGIDPNFKMEHQNKRSP 776
           E+P+K R H K+                +AR G L+K L  + +G+D N    +QN  + 
Sbjct: 20  EEPEKKRKHRKRSRDRKKKSDANASYLRAARAGHLEKALDYIKNGVDINIC--NQNGLNA 77

Query: 777 LHAAAEAGHVDICHMLVQAGANIDTCSEDQRTPLMEAAENNHLEAVKYLIKAGALVDPKD 836
           LH A++ GHV++   L+Q  AN+D  ++   T L  A+     E VK L+  GA V+ + 
Sbjct: 78  LHLASKEGHVEVVSELLQREANVDAATKKGNTALHIASLAGQAEVVKVLVTNGANVNAQS 137

Query: 837 AEGSTCLHLAAKKGHYEVVQYLLSNGQMDVNCQDDGGWTPMIWATEYKHVDLVKLLLSKG 896
             G T L++AA++ H EVV++LL NG       +D G+TP+  A +  H  +V LLL   
Sbjct: 138 QNGFTPLYMAAQENHLEVVKFLLDNGASQSLATED-GFTPLAVALQQGHDQVVSLLLEND 196

Query: 897 SDINIR----------------------DNEENI-------CLHWAAFSGCVDIAEILL- 926
           +   +R                      DN  ++        LH AA  G +++A +LL 
Sbjct: 197 TKGKVRLPALHIAARKDDTKAAALLLQNDNNADVESKSGFTPLHIAAHYGNINVATLLLN 256

Query: 927 -AAKCDLHAVNIHGDSPLHIAARENRYDCVVLFLSRDSDVTLKNKEGETPLQCAS 980
            AA  D  A N    +PLH+A++    + V L L R + +  K ++G TPL C +
Sbjct: 257 RAAAVDFTARN--DITPLHVASKRGNANMVKLLLDRGAKIDAKTRDGLTPLHCGA 309



 Score =  112 bits (280), Expect = 2e-24
 Identities = 72/244 (29%), Positives = 123/244 (50%), Gaps = 3/244 (1%)

Query: 742 LYFSARQGELQKVLLMLVDGIDPNFKMEHQNKRSPLHAAAEAGHVDICHMLVQAGANIDT 801
           L+ + ++  ++ + L+L  G   + +   ++  +P+H AA  GHV+I   L+  GA+ +T
Sbjct: 404 LHIACKKNRIKVMELLLKHGA--SIQAVTESGLTPIHVAAFMGHVNIVSQLMHHGASPNT 461

Query: 802 CSEDQRTPLMEAAENNHLEAVKYLIKAGALVDPKDAEGSTCLHLAAKKGHYEVVQYLLSN 861
            +    T L  AA +   E V+YL++ GA V+ K  +  T LH++A+ G  ++VQ LL  
Sbjct: 462 TNVRGETALHMAARSGQAEVVRYLVQDGAQVEAKAKDDQTPLHISARLGKADIVQQLLQQ 521

Query: 862 GQMDVNCQDDGGWTPMIWATEYKHVDLVKLLLSKGSDINIRDNEENICLHWAAFSGCVDI 921
           G    N     G+TP+  +    H D+   LL  G+ ++I   +    LH AA  G +++
Sbjct: 522 G-ASPNAATTSGYTPLHLSAREGHEDVAAFLLDHGASLSITTKKGFTPLHVAAKYGKLEV 580

Query: 922 AEILLAAKCDLHAVNIHGDSPLHIAARENRYDCVVLFLSRDSDVTLKNKEGETPLQCASL 981
           A +LL       A    G +PLH+AA  +     +L L + +      K G TPL  A+ 
Sbjct: 581 ANLLLQKSASPDAAGKSGLTPLHVAAHYDNQKVALLLLDQGASPHAAAKNGYTPLHIAAK 640

Query: 982 NSQV 985
            +Q+
Sbjct: 641 KNQM 644



 Score =  110 bits (275), Expect = 9e-24
 Identities = 73/235 (31%), Positives = 116/235 (49%), Gaps = 3/235 (1%)

Query: 742 LYFSARQGELQKVLLMLVDGIDPNFKMEHQNKRSPLHAAAEAGHVDICHMLVQAGANIDT 801
           L+ SAR G+   V  +L  G  PN      +  +PLH +A  GH D+   L+  GA++  
Sbjct: 503 LHISARLGKADIVQQLLQQGASPNAATT--SGYTPLHLSAREGHEDVAAFLLDHGASLSI 560

Query: 802 CSEDQRTPLMEAAENNHLEAVKYLIKAGALVDPKDAEGSTCLHLAAKKGHYEVVQYLLSN 861
            ++   TPL  AA+   LE    L++  A  D     G T LH+AA   + +V   LL  
Sbjct: 561 TTKKGFTPLHVAAKYGKLEVANLLLQKSASPDAAGKSGLTPLHVAAHYDNQKVALLLLDQ 620

Query: 862 GQMDVNCQDDGGWTPMIWATEYKHVDLVKLLLSKGSDINIRDNEENICLHWAAFSGCVDI 921
           G    +     G+TP+  A +   +D+   LL  G+D N    +    +H AA  G VD+
Sbjct: 621 GASP-HAAAKNGYTPLHIAAKKNQMDIATTLLEYGADANAVTRQGIASVHLAAQEGHVDM 679

Query: 922 AEILLAAKCDLHAVNIHGDSPLHIAARENRYDCVVLFLSRDSDVTLKNKEGETPL 976
             +LL    +++  N  G +PLH+AA+E+R +   + +++ + V  + K G TPL
Sbjct: 680 VSLLLGRNANVNLSNKSGLTPLHLAAQEDRVNVAEVLVNQGAHVDAQTKMGYTPL 734



 Score =  110 bits (274), Expect = 1e-23
 Identities = 73/240 (30%), Positives = 117/240 (48%), Gaps = 5/240 (2%)

Query: 742 LYFSARQGELQKVLLMLVDGIDPNFKMEHQNKRSPLHAAAEAGHVDICHMLVQAGANIDT 801
           L+ +A  G  +   ++L    +PN K    N  +PLH A +   + +  +L++ GA+I  
Sbjct: 371 LHVAAHCGHYKVAKVLLDKKANPNAKA--LNGFTPLHIACKKNRIKVMELLLKHGASIQA 428

Query: 802 CSEDQRTPLMEAAENNHLEAVKYLIKAGALVDPKDAEGSTCLHLAAKKGHYEVVQYLLSN 861
            +E   TP+  AA   H+  V  L+  GA  +  +  G T LH+AA+ G  EVV+YL+ +
Sbjct: 429 VTESGLTPIHVAAFMGHVNIVSQLMHHGASPNTTNVRGETALHMAARSGQAEVVRYLVQD 488

Query: 862 G-QMDVNCQDDGGWTPMIWATEYKHVDLVKLLLSKGSDINIRDNEENICLHWAAFSGCVD 920
           G Q++   +DD   TP+  +      D+V+ LL +G+  N         LH +A  G  D
Sbjct: 489 GAQVEAKAKDD--QTPLHISARLGKADIVQQLLQQGASPNAATTSGYTPLHLSAREGHED 546

Query: 921 IAEILLAAKCDLHAVNIHGDSPLHIAARENRYDCVVLFLSRDSDVTLKNKEGETPLQCAS 980
           +A  LL     L      G +PLH+AA+  + +   L L + +      K G TPL  A+
Sbjct: 547 VAAFLLDHGASLSITTKKGFTPLHVAAKYGKLEVANLLLQKSASPDAAGKSGLTPLHVAA 606



 Score =  105 bits (261), Expect = 4e-22
 Identities = 82/279 (29%), Positives = 129/279 (46%), Gaps = 10/279 (3%)

Query: 742  LYFSARQGELQKVLLMLVDGIDPNFKMEHQNKRSPLHAAAEAGHVDICHMLVQAGANIDT 801
            L+ SAR+G       +L  G   +  +  +   +PLH AA+ G +++ ++L+Q  A+ D 
Sbjct: 536  LHLSAREGHEDVAAFLLDHGA--SLSITTKKGFTPLHVAAKYGKLEVANLLLQKSASPDA 593

Query: 802  CSEDQRTPLMEAAENNHLEAVKYLIKAGALVDPKDAEGSTCLHLAAKKGHYEVVQYLLSN 861
              +   TPL  AA  ++ +    L+  GA        G T LH+AAKK   ++   LL  
Sbjct: 594  AGKSGLTPLHVAAHYDNQKVALLLLDQGASPHAAAKNGYTPLHIAAKKNQMDIATTLLEY 653

Query: 862  GQMDVNCQDDGGWTPMIWATEYKHVDLVKLLLSKGSDINIRDNEENICLHWAAFSGCVDI 921
            G  D N     G   +  A +  HVD+V LLL + +++N+ +      LH AA    V++
Sbjct: 654  GA-DANAVTRQGIASVHLAAQEGHVDMVSLLLGRNANVNLSNKSGLTPLHLAAQEDRVNV 712

Query: 922  AEILLAAKCDLHAVNIHGDSPLHIAARENRYDCVVLFLSRDSDVTLKNKEGETPLQCASL 981
            AE+L+     + A    G +PLH+         V   L   + V  K K G TPL  A  
Sbjct: 713  AEVLVNQGAHVDAQTKMGYTPLHVGCHYGNIKIVNFLLQHSAKVNAKTKNGYTPLHQA-- 770

Query: 982  NSQVWSALQMSKALQDSAPDRPSPVERIVSRDIARGYER 1020
             +Q      ++  LQ++A    SP E  V+ + A G  R
Sbjct: 771  -AQQGHTHIINVLLQNNA----SPNELTVNGNTALGIAR 804



 Score = 50.4 bits (119), Expect = 1e-05
 Identities = 30/119 (25%), Positives = 60/119 (50%), Gaps = 6/119 (5%)

Query: 742 LYFSARQGELQKVLLMLVDG--IDPNFKMEHQNKRSPLHAAAEAGHVDICHMLVQAGANI 799
           L+ +A++  +    +++  G  +D   KM +    +PLH     G++ I + L+Q  A +
Sbjct: 701 LHLAAQEDRVNVAEVLVNQGAHVDAQTKMGY----TPLHVGCHYGNIKIVNFLLQHSAKV 756

Query: 800 DTCSEDQRTPLMEAAENNHLEAVKYLIKAGALVDPKDAEGSTCLHLAAKKGHYEVVQYL 858
           +  +++  TPL +AA+  H   +  L++  A  +     G+T L +A + G+  VV  L
Sbjct: 757 NAKTKNGYTPLHQAAQQGHTHIINVLLQNNASPNELTVNGNTALGIARRLGYISVVDTL 815



 Score = 38.5 bits (88), Expect = 0.042
 Identities = 23/72 (31%), Positives = 39/72 (54%)

Query: 913 AAFSGCVDIAEILLAAKCDLHAVNIHGDSPLHIAARENRYDCVVLFLSRDSDVTLKNKEG 972
           AA +G ++ A   +    D++  N +G + LH+A++E   + V   L R+++V    K+G
Sbjct: 48  AARAGHLEKALDYIKNGVDINICNQNGLNALHLASKEGHVEVVSELLQREANVDAATKKG 107

Query: 973 ETPLQCASLNSQ 984
            T L  ASL  Q
Sbjct: 108 NTALHIASLAGQ 119


>gi|55742857 ankyrin repeat domain 6 [Homo sapiens]
          Length = 722

 Score =  123 bits (309), Expect = 1e-27
 Identities = 77/257 (29%), Positives = 134/257 (52%), Gaps = 4/257 (1%)

Query: 740 KQLYFSARQGELQKVLLMLVDGIDPNFKMEHQNKRSPLHAAAEAGHVDICHMLVQAGANI 799
           ++L  +A +G+ + V+ ++  G         ++ R+PLH AA  GH+ +  +L++AG ++
Sbjct: 12  ERLLVAAYKGQTENVVQLINKGARVAVT---KHGRTPLHLAANKGHLPVVQILLKAGCDL 68

Query: 800 DTCSEDQRTPLMEAAENNHLEAVKYLIKAGALVDPKDAEGSTCLHLAAKKGHYEVVQYLL 859
           D   +  +T L  A    + E +  LI  G  +D +D +G+T LH A+  G  +  + L+
Sbjct: 69  DVQDDGDQTALHRATVVGNTEIIAALIHEGCALDRQDKDGNTALHEASWHGFSQSAKLLV 128

Query: 860 SNGQMDVNCQDDGGWTPMIWATEYKHVDLVKLLLSKGSDINIRDNEENICLHWAAFSGCV 919
             G  +V  ++  G T +  A +  H    ++LL  GS  ++++N  + CLH AA    +
Sbjct: 129 KAGA-NVLAKNKAGNTALHLACQNSHSQSTRVLLLAGSRADLKNNAGDTCLHVAARYNHL 187

Query: 920 DIAEILLAAKCDLHAVNIHGDSPLHIAARENRYDCVVLFLSRDSDVTLKNKEGETPLQCA 979
            I  +LL A C +H  N  GD+ LH+AA  N      + L   +D T+ N  G+TPL+ A
Sbjct: 188 SIIRLLLTAFCSVHEKNQAGDTALHVAAALNHKKVAKILLEAGADTTIVNNAGQTPLETA 247

Query: 980 SLNSQVWSALQMSKALQ 996
             ++    AL ++KA Q
Sbjct: 248 RYHNNPEVALLLTKAPQ 264



 Score = 38.9 bits (89), Expect = 0.032
 Identities = 32/123 (26%), Positives = 54/123 (43%), Gaps = 2/123 (1%)

Query: 742 LYFSARQGELQKVLLMLVDGIDPNFKMEHQNKRSPLHAAAEAGHVDICHMLVQAGANIDT 801
           L+ + +    Q   ++L+ G   + K    +  + LH AA   H+ I  +L+ A  ++  
Sbjct: 145 LHLACQNSHSQSTRVLLLAGSRADLKNNAGD--TCLHVAARYNHLSIIRLLLTAFCSVHE 202

Query: 802 CSEDQRTPLMEAAENNHLEAVKYLIKAGALVDPKDAEGSTCLHLAAKKGHYEVVQYLLSN 861
            ++   T L  AA  NH +  K L++AGA     +  G T L  A    + EV   L   
Sbjct: 203 KNQAGDTALHVAAALNHKKVAKILLEAGADTTIVNNAGQTPLETARYHNNPEVALLLTKA 262

Query: 862 GQM 864
            Q+
Sbjct: 263 PQV 265


>gi|87239981 tankyrase, TRF1-interacting ankyrin-related ADP-ribose
           polymerase [Homo sapiens]
          Length = 1327

 Score =  120 bits (301), Expect = 8e-27
 Identities = 88/265 (33%), Positives = 133/265 (50%), Gaps = 26/265 (9%)

Query: 738 HPKQLYFSARQGELQKVLLMLVDGIDPNFKMEHQNKRSPLHAAAEAGHVDICHMLVQAGA 797
           H   L+F+A    +  V  +L  G D + K   +    PLH A   GH ++  +LV+ GA
Sbjct: 684 HSTPLHFAAGYNRVSVVEYLLHHGADVHAK--DKGGLVPLHNACSYGHYEVAELLVRHGA 741

Query: 798 NIDTCSEDQRTPLMEAAENNHLEAVKYLIKAGALVDPKDAEGSTCLHL------------ 845
           +++     + TPL EAA     E  K L+K GA    K+ +G+T L L            
Sbjct: 742 SVNVADLWKFTPLHEAAAKGKYEICKLLLKHGADPTKKNRDGNTPLDLVKEGDTDIQDLL 801

Query: 846 --------AAKKGHYEVVQYLLSNGQMDVNCQDDGGW--TPMIWATEYKHVDLVKLLLSK 895
                   AAKKG    VQ L +    ++NC+D  G   TP+  A  Y ++++ + LL  
Sbjct: 802 RGDAALLDAAKKGCLARVQKLCT--PENINCRDTQGRNSTPLHLAAGYNNLEVAEYLLEH 859

Query: 896 GSDINIRDNEENICLHWAAFSGCVDIAEILLAAKCDLHAVNIHGDSPLHIAARENRYDCV 955
           G+D+N +D    I LH AA  G VDIA +L+     ++A +    +PLH AA++ R    
Sbjct: 860 GADVNAQDKGGLIPLHNAASYGHVDIAALLIKYNTCVNATDKWAFTPLHEAAQKGRTQLC 919

Query: 956 VLFLSRDSDVTLKNKEGETPLQCAS 980
            L L+  +D T+KN+EG+TPL  A+
Sbjct: 920 ALLLAHGADPTMKNQEGQTPLDLAT 944



 Score =  109 bits (273), Expect = 1e-23
 Identities = 110/414 (26%), Positives = 161/414 (38%), Gaps = 77/414 (18%)

Query: 621 VNNASYCPHCGEESSKAKEVTIAKADTTST--VTPVPGQEKGSALEGRADTTTGSAAGPP 678
           V+  S C       + A    +    T+S   V P P     +     + + T S++  P
Sbjct: 84  VDGTSCCSTTSTICTVAAAPVVPAVSTSSAAGVAPNPAGSGSNNSPSSSSSPTSSSSSSP 143

Query: 679 LSEDDKLQGAASHVPEGFDPTGPAGLGRPTPGLSQGPGKETLESALIALDSEKPKKLRFH 738
            S    L  A S    G   T P G G   PG     G   +  AL              
Sbjct: 144 SSPGSSL--AESPEAAGVSSTAPLGPGAAGPGT----GVPAVSGAL-------------- 183

Query: 739 PKQLYFSARQGELQKVLLMLVDGIDPNFKMEHQNKRSPLHAAAEAGHVDICHMLVQAGAN 798
            ++L  + R G++ +V   LVD  + N K     K SPLH AA  G  D+   L+Q GAN
Sbjct: 184 -RELLEACRNGDVSRVK-RLVDAANVNAKDMAGRKSSPLHFAAGFGRKDVVEHLLQMGAN 241

Query: 799 IDTCSEDQRTPLMEAAENNHLEAVKYLIKAGALVDPKDAEGSTCLHLAAKKGHYEVVQYL 858
           +    +    PL  A    H E V  L+  GA  + +D    T LH AA KG  +V   L
Sbjct: 242 VHARDDGGLIPLHNACSFGHAEVVSLLLCQGADPNARDNWNYTPLHEAAIKGKIDVCIVL 301

Query: 859 LSNGQ---------------------------------------------------MDVN 867
           L +G                                                    ++VN
Sbjct: 302 LQHGADPNIRNTDGKSALDLADPSAKAVLTGEYKKDELLEAARSGNEEKLMALLTPLNVN 361

Query: 868 CQDDGGW--TPMIWATEYKHVDLVKLLLSKGSDINIRDNEENICLHWAAFSGCVDIAEIL 925
           C    G   TP+  A  Y  V +V+LLL  G+D++ +D    + LH A   G  ++ E+L
Sbjct: 362 CHASDGRKSTPLHLAAGYNRVRIVQLLLQHGADVHAKDKGGLVPLHNACSYGHYEVTELL 421

Query: 926 LAAKCDLHAVNIHGDSPLHIAARENRYDCVVLFLSRDSDVTLKNKEGETPLQCA 979
           L     ++A+++   +PLH AA +NR +   L LS  +D TL N  G++ +  A
Sbjct: 422 LKHGACVNAMDLWQFTPLHEAASKNRVEVCSLLLSHGADPTLVNCHGKSAVDMA 475



 Score =  103 bits (257), Expect = 1e-21
 Identities = 91/326 (27%), Positives = 143/326 (43%), Gaps = 65/326 (19%)

Query: 737 FHPKQLYFSARQGELQKVLLMLVDGIDPNFKMEHQNKRSPLHAAAEAGHV---DICHMLV 793
           F    L  +AR+ +L KV   L   I  NFK + Q+  + LH A  + H     +  +L+
Sbjct: 488 FKGHSLLQAAREADLAKVKKTLALEII-NFK-QPQSHETALHCAVASLHPKRKQVTELLL 545

Query: 794 QAGANIDTCSEDQRTPLMEAAENNHLEAVKYLIKAGALVDPKDAEGSTCLHLAAKKGHY- 852
           + GAN++  ++D  TPL  AAE  H + ++ L K GA ++  D  G T LH AA  GH  
Sbjct: 546 RKGANVNEKNKDFMTPLHVAAERAHNDVMEVLHKHGAKMNALDTLGQTALHRAALAGHLQ 605

Query: 853 ---------------------------EVVQYLLSNG----------------------- 862
                                      E VQ +LS                         
Sbjct: 606 TCRLLLSYGSDPSIISLQGFTAAQMGNEAVQQILSESTPIRTSDVDYRLLEASKAGDLET 665

Query: 863 ------QMDVNCQDDGGW--TPMIWATEYKHVDLVKLLLSKGSDINIRDNEENICLHWAA 914
                   +VNC+D  G   TP+ +A  Y  V +V+ LL  G+D++ +D    + LH A 
Sbjct: 666 VKQLCSSQNVNCRDLEGRHSTPLHFAAGYNRVSVVEYLLHHGADVHAKDKGGLVPLHNAC 725

Query: 915 FSGCVDIAEILLAAKCDLHAVNIHGDSPLHIAARENRYDCVVLFLSRDSDVTLKNKEGET 974
             G  ++AE+L+     ++  ++   +PLH AA + +Y+   L L   +D T KN++G T
Sbjct: 726 SYGHYEVAELLVRHGASVNVADLWKFTPLHEAAAKGKYEICKLLLKHGADPTKKNRDGNT 785

Query: 975 PLQCASL-NSQVWSALQMSKALQDSA 999
           PL      ++ +   L+   AL D+A
Sbjct: 786 PLDLVKEGDTDIQDLLRGDAALLDAA 811



 Score = 73.9 bits (180), Expect = 9e-13
 Identities = 83/300 (27%), Positives = 125/300 (41%), Gaps = 34/300 (11%)

Query: 709 PGLSQGPGKETLE----SALIALDSEKPKKLRFHPKQLYFSARQGELQKVLLMLVDGIDP 764
           P +    GK  L+    SA   L  E  K       +L  +AR G  +K++ +L   ++ 
Sbjct: 308 PNIRNTDGKSALDLADPSAKAVLTGEYKKD------ELLEAARSGNEEKLMALLTP-LNV 360

Query: 765 NFKMEHQNKRSPLHAAAEAGHVDICHMLVQAGANIDTCSEDQRTPLMEAAENNHLEAVKY 824
           N       K +PLH AA    V I  +L+Q GA++    +    PL  A    H E  + 
Sbjct: 361 NCHASDGRKSTPLHLAAGYNRVRIVQLLLQHGADVHAKDKGGLVPLHNACSYGHYEVTEL 420

Query: 825 LIKAGALVDPKDAEGSTCLHLAAKKGHYEVVQYLLSNGQMD--VNCQD----DGGWTPMI 878
           L+K GA V+  D    T LH AA K   EV   LLS+G     VNC      D   TP +
Sbjct: 421 LLKHGACVNAMDLWQFTPLHEAASKNRVEVCSLLLSHGADPTLVNCHGKSAVDMAPTPEL 480

Query: 879 ---WATEYK---------HVDLVKLLLSKGSDI-NIRDNEEN-ICLHWAAFS---GCVDI 921
                 E+K           DL K+  +   +I N +  + +   LH A  S       +
Sbjct: 481 RERLTYEFKGHSLLQAAREADLAKVKKTLALEIINFKQPQSHETALHCAVASLHPKRKQV 540

Query: 922 AEILLAAKCDLHAVNIHGDSPLHIAARENRYDCVVLFLSRDSDVTLKNKEGETPLQCASL 981
            E+LL    +++  N    +PLH+AA     D + +     + +   +  G+T L  A+L
Sbjct: 541 TELLLRKGANVNEKNKDFMTPLHVAAERAHNDVMEVLHKHGAKMNALDTLGQTALHRAAL 600



 Score = 40.4 bits (93), Expect = 0.011
 Identities = 32/116 (27%), Positives = 55/116 (47%), Gaps = 3/116 (2%)

Query: 872 GGWTPMIWATEYKHVDLVKLLLSKGSDINIRD--NEENICLHWAAFSGCVDIAEILLAAK 929
           G    ++ A     V  VK L+   +++N +D    ++  LH+AA  G  D+ E LL   
Sbjct: 181 GALRELLEACRNGDVSRVKRLVD-AANVNAKDMAGRKSSPLHFAAGFGRKDVVEHLLQMG 239

Query: 930 CDLHAVNIHGDSPLHIAARENRYDCVVLFLSRDSDVTLKNKEGETPLQCASLNSQV 985
            ++HA +  G  PLH A      + V L L + +D   ++    TPL  A++  ++
Sbjct: 240 ANVHARDDGGLIPLHNACSFGHAEVVSLLLCQGADPNARDNWNYTPLHEAAIKGKI 295


>gi|55741641 kinase D-interacting substrate of 220 kDa [Homo
           sapiens]
          Length = 1771

 Score =  120 bits (301), Expect = 8e-27
 Identities = 85/271 (31%), Positives = 128/271 (47%), Gaps = 36/271 (13%)

Query: 742 LYFSARQGELQKVLLMLVDGIDPNFKMEHQNKRSPLHAAAEAGHVDICHMLVQAGANIDT 801
           L ++  +G    V L+L  G +P+    +     P+  AA  GH DI H+L+Q GA ++ 
Sbjct: 108 LMWACYKGRTDVVELLLSHGANPSVTGLYSVY--PIIWAAGRGHADIVHLLLQNGAKVNC 165

Query: 802 CSEDQRTPLMEAAENNHLEAVKYLIKAGALVDPK-------------------------- 835
             +   TPL+ AA   HLE VK+L+  GA VD +                          
Sbjct: 166 SDKYGTTPLVWAARKGHLECVKHLLAMGADVDQEGANSMTALIVAVKGGYTQSVKEILKR 225

Query: 836 -------DAEGSTCLHLAAKKGHYEVVQYLLSNGQMDVNCQDDGGWTPMIWATEYKHVDL 888
                  D +G+T L +A+K+GH E+VQ LL  G   VN  D  G T +I A    HV++
Sbjct: 226 NPNVNLTDKDGNTALMIASKEGHTEIVQDLLDAGTY-VNIPDRSGDTVLIGAVRGGHVEI 284

Query: 889 VKLLLSKGSDINIRDNEENICLHWAAFSGCVDIAEILLAAKCDLHAVNIHGDSPLHIAAR 948
           V+ LL K +DI+IR  +    L+WA   G   +   +L    D       G++PL  A +
Sbjct: 285 VRALLQKYADIDIRGQDNKTALYWAVEKGNATMVRDILQCNPDTEICTKDGETPLIKATK 344

Query: 949 ENRYDCVVLFLSRDSDVTLKNKEGETPLQCA 979
               + V L L + + V+  +K+G+TPL  A
Sbjct: 345 MRNIEVVELLLDKGAKVSAVDKKGDTPLHIA 375



 Score =  105 bits (261), Expect = 4e-22
 Identities = 70/209 (33%), Positives = 108/209 (51%), Gaps = 5/209 (2%)

Query: 774 RSPLHAAAEAGHVDICHMLVQAGANIDTCSEDQRTPLMEAAENNHLEAVKYLIKAGALVD 833
           ++PL  AAE G+++I   L++ GAN +    D  T L+ A++  H+  V+ L+K G  ++
Sbjct: 39  QTPLMIAAEQGNLEIVKELIKNGANCNLEDLDNWTALISASKEGHVHIVEELLKCGVNLE 98

Query: 834 PKDAEGSTCLHLAAKKGHYEVVQYLLSNGQMDVNCQDDGGWT--PMIWATEYKHVDLVKL 891
            +D  G T L  A  KG  +VV+ LLS+G    N    G ++  P+IWA    H D+V L
Sbjct: 99  HRDMGGWTALMWACYKGRTDVVELLLSHG---ANPSVTGLYSVYPIIWAAGRGHADIVHL 155

Query: 892 LLSKGSDINIRDNEENICLHWAAFSGCVDIAEILLAAKCDLHAVNIHGDSPLHIAARENR 951
           LL  G+ +N  D      L WAA  G ++  + LLA   D+     +  + L +A +   
Sbjct: 156 LLQNGAKVNCSDKYGTTPLVWAARKGHLECVKHLLAMGADVDQEGANSMTALIVAVKGGY 215

Query: 952 YDCVVLFLSRDSDVTLKNKEGETPLQCAS 980
              V   L R+ +V L +K+G T L  AS
Sbjct: 216 TQSVKEILKRNPNVNLTDKDGNTALMIAS 244



 Score =  104 bits (259), Expect = 6e-22
 Identities = 69/212 (32%), Positives = 111/212 (52%), Gaps = 1/212 (0%)

Query: 782 EAGHVDICHMLVQAGANIDTCSEDQRTPLMEAAENNHLEAVKYLIKAGALVDPKDAEGST 841
           E  ++     L++   ++D  +E  +TPLM AAE  +LE VK LIK GA  + +D +  T
Sbjct: 14  EEENIPALKALLEKCKDVDERNECGQTPLMIAAEQGNLEIVKELIKNGANCNLEDLDNWT 73

Query: 842 CLHLAAKKGHYEVVQYLLSNGQMDVNCQDDGGWTPMIWATEYKHVDLVKLLLSKGSDINI 901
            L  A+K+GH  +V+ LL  G +++  +D GGWT ++WA      D+V+LLLS G++ ++
Sbjct: 74  ALISASKEGHVHIVEELLKCG-VNLEHRDMGGWTALMWACYKGRTDVVELLLSHGANPSV 132

Query: 902 RDNEENICLHWAAFSGCVDIAEILLAAKCDLHAVNIHGDSPLHIAARENRYDCVVLFLSR 961
                   + WAA  G  DI  +LL     ++  + +G +PL  AAR+   +CV   L+ 
Sbjct: 133 TGLYSVYPIIWAAGRGHADIVHLLLQNGAKVNCSDKYGTTPLVWAARKGHLECVKHLLAM 192

Query: 962 DSDVTLKNKEGETPLQCASLNSQVWSALQMSK 993
            +DV  +     T L  A       S  ++ K
Sbjct: 193 GADVDQEGANSMTALIVAVKGGYTQSVKEILK 224



 Score = 92.4 bits (228), Expect = 2e-18
 Identities = 66/235 (28%), Positives = 113/235 (48%), Gaps = 3/235 (1%)

Query: 742 LYFSARQGELQKVLLMLVDGIDPNFKMEHQNKRSPLHAAAEAGHVDICHMLVQAGANIDT 801
           L  +A QG L+ V  ++ +G + N  +E  +  + L +A++ GHV I   L++ G N++ 
Sbjct: 42  LMIAAEQGNLEIVKELIKNGANCN--LEDLDNWTALISASKEGHVHIVEELLKCGVNLEH 99

Query: 802 CSEDQRTPLMEAAENNHLEAVKYLIKAGALVDPKDAEGSTCLHLAAKKGHYEVVQYLLSN 861
                 T LM A      + V+ L+  GA            +  AA +GH ++V  LL N
Sbjct: 100 RDMGGWTALMWACYKGRTDVVELLLSHGANPSVTGLYSVYPIIWAAGRGHADIVHLLLQN 159

Query: 862 GQMDVNCQDDGGWTPMIWATEYKHVDLVKLLLSKGSDINIRDNEENICLHWAAFSGCVDI 921
           G   VNC D  G TP++WA    H++ VK LL+ G+D++         L  A   G    
Sbjct: 160 G-AKVNCSDKYGTTPLVWAARKGHLECVKHLLAMGADVDQEGANSMTALIVAVKGGYTQS 218

Query: 922 AEILLAAKCDLHAVNIHGDSPLHIAARENRYDCVVLFLSRDSDVTLKNKEGETPL 976
            + +L    +++  +  G++ L IA++E   + V   L   + V + ++ G+T L
Sbjct: 219 VKEILKRNPNVNLTDKDGNTALMIASKEGHTEIVQDLLDAGTYVNIPDRSGDTVL 273



 Score = 57.0 bits (136), Expect = 1e-07
 Identities = 32/112 (28%), Positives = 60/112 (53%), Gaps = 4/112 (3%)

Query: 750 ELQKVLLMLVDGIDPNFKMEHQNKRSPLHAAAEAGHVDICHMLVQAGANIDTCSEDQRTP 809
           E+ + LL     ID    +  Q+ ++ L+ A E G+  +   ++Q   + + C++D  TP
Sbjct: 283 EIVRALLQKYADID----IRGQDNKTALYWAVEKGNATMVRDILQCNPDTEICTKDGETP 338

Query: 810 LMEAAENNHLEAVKYLIKAGALVDPKDAEGSTCLHLAAKKGHYEVVQYLLSN 861
           L++A +  ++E V+ L+  GA V   D +G T LH+A +    ++ + LL N
Sbjct: 339 LIKATKMRNIEVVELLLDKGAKVSAVDKKGDTPLHIAIRGRSRKLAELLLRN 390


>gi|68131557 ankyrin repeat domain 28 [Homo sapiens]
          Length = 1053

 Score =  119 bits (297), Expect = 2e-26
 Identities = 84/254 (33%), Positives = 126/254 (49%), Gaps = 10/254 (3%)

Query: 734 KLRFHPKQLYFSARQGELQKVLLMLVDGIDPNFKMEHQNKRSPLHAAAEAGHVDICHMLV 793
           KLR  P  L  +   G+  +V  ++    D NF  +   KR+PLHAAA  G  +I  +L+
Sbjct: 5   KLRDQPS-LVQAIFNGDPDEVRALIFKKEDVNF--QDNEKRTPLHAAAYLGDAEIIELLI 61

Query: 794 QAGANIDTCSEDQRTPLMEAAENNHLEAVKYLIKAGALVDPKDAEGSTCLHLAAKKGHY- 852
            +GA ++       TPL  A  +   EAV+ L+K  A V+ +D    T LH+AA      
Sbjct: 62  LSGARVNAKDSKWLTPLHRAVASCSEEAVQVLLKHSADVNARDKNWQTPLHIAAANKAVK 121

Query: 853 --EVVQYLLSNGQMDVNCQDDGGWTPMIWATEYKHVDLVKLLLSKGSDINIRDNEENICL 910
             E +  LLSN    VN  D  G T +  A    H ++VKLLLS+G++IN  D ++   +
Sbjct: 122 CAEALVPLLSN----VNVSDRAGRTALHHAAFSGHGEMVKLLLSRGANINAFDKKDRRAI 177

Query: 911 HWAAFSGCVDIAEILLAAKCDLHAVNIHGDSPLHIAARENRYDCVVLFLSRDSDVTLKNK 970
           HWAA+ G +++ ++L++   ++   +    +PLH AA       V   L    D+   N 
Sbjct: 178 HWAAYMGHIEVVKLLVSHGAEVTCKDKKSYTPLHAAASSGMISVVKYLLDLGVDMNEPNA 237

Query: 971 EGETPLQCASLNSQ 984
            G TPL  A  N Q
Sbjct: 238 YGNTPLHVACYNGQ 251



 Score =  108 bits (271), Expect = 3e-23
 Identities = 76/242 (31%), Positives = 121/242 (50%), Gaps = 4/242 (1%)

Query: 742 LYFSARQGELQKVLLMLVDGIDPNFKMEHQNKRSPLHAAAEAGHVDICHMLVQAGANIDT 801
           L+ +A  G +  V  +L  G+D N    + N  +PLH A   G   + + L+  GA ++ 
Sbjct: 210 LHAAASSGMISVVKYLLDLGVDMNEPNAYGN--TPLHVACYNGQDVVVNELIDCGAIVNQ 267

Query: 802 CSEDQRTPLMEAAENNH-LEAVKYLIKAGALVDPKDAEGSTCLHLAAKKGHYEVVQYLLS 860
            +E   TPL  AA + H    ++ L+  GA V+ K  +G T LH+ A  G +   Q ++ 
Sbjct: 268 KNEKGFTPLHFAAASTHGALCLELLVGNGADVNMKSKDGKTPLHMTALHGRFSRSQTIIQ 327

Query: 861 NGQMDVNCQDDGGWTPMIWATEYKHVDLVKLLLSKGSDINIRDNEENICLHWAAFSGCVD 920
           +G + ++C+D  G TP+  A  Y H  L+  L++ G+D   R       LH AA SG  D
Sbjct: 328 SGAV-IDCEDKNGNTPLHIAARYGHELLINTLITSGADTAKRGIHGMFPLHLAALSGFSD 386

Query: 921 IAEILLAAKCDLHAVNIHGDSPLHIAARENRYDCVVLFLSRDSDVTLKNKEGETPLQCAS 980
               LL++  D+   +  G + LH AA     +C+ L L+  +D   K+K G +PL  A+
Sbjct: 387 CCRKLLSSGFDIDTPDDFGRTCLHAAAAGGNLECLNLLLNTGADFNKKDKFGRSPLHYAA 446

Query: 981 LN 982
            N
Sbjct: 447 AN 448



 Score =  100 bits (249), Expect = 9e-21
 Identities = 70/241 (29%), Positives = 110/241 (45%), Gaps = 2/241 (0%)

Query: 740 KQLYFSARQGELQKVLLMLVDGIDPNFKMEHQNKRSPLHAAAEAGHVDICHMLVQAGANI 799
           + ++++A  G ++ V L++  G +   K   +   +PLHAAA +G + +   L+  G ++
Sbjct: 175 RAIHWAAYMGHIEVVKLLVSHGAEVTCK--DKKSYTPLHAAASSGMISVVKYLLDLGVDM 232

Query: 800 DTCSEDQRTPLMEAAENNHLEAVKYLIKAGALVDPKDAEGSTCLHLAAKKGHYEVVQYLL 859
           +  +    TPL  A  N     V  LI  GA+V+ K+ +G T LH AA   H  +   LL
Sbjct: 233 NEPNAYGNTPLHVACYNGQDVVVNELIDCGAIVNQKNEKGFTPLHFAAASTHGALCLELL 292

Query: 860 SNGQMDVNCQDDGGWTPMIWATEYKHVDLVKLLLSKGSDINIRDNEENICLHWAAFSGCV 919
                DVN +   G TP+     +      + ++  G+ I+  D   N  LH AA  G  
Sbjct: 293 VGNGADVNMKSKDGKTPLHMTALHGRFSRSQTIIQSGAVIDCEDKNGNTPLHIAARYGHE 352

Query: 920 DIAEILLAAKCDLHAVNIHGDSPLHIAARENRYDCVVLFLSRDSDVTLKNKEGETPLQCA 979
            +   L+ +  D     IHG  PLH+AA     DC    LS   D+   +  G T L  A
Sbjct: 353 LLINTLITSGADTAKRGIHGMFPLHLAALSGFSDCCRKLLSSGFDIDTPDDFGRTCLHAA 412

Query: 980 S 980
           +
Sbjct: 413 A 413



 Score = 99.0 bits (245), Expect = 3e-20
 Identities = 77/237 (32%), Positives = 114/237 (48%), Gaps = 11/237 (4%)

Query: 755 LLMLVDGIDPNFKMEHQNKRSPLHAAAEAGHVDICHMLVQAGANIDTCSEDQRTPLMEAA 814
           +LM   G D     +++   SPLH AA  GH     +LVQ+  ++D  +   RTPL  AA
Sbjct: 532 VLMETSGTDMLSDSDNRATISPLHLAAYHGHHQALEVLVQSLLDLDVRNSSGRTPLDLAA 591

Query: 815 ENNHLEAVKYLIKAGALVDPKD-AEGSTCLHLAAKKGHYEVVQYLLSNG--QMDVNCQDD 871
              H+E V  LI  GA +  KD     T +H AA  GH E ++ L+ N   Q  V+ QD 
Sbjct: 592 FKGHVECVDVLINQGASILVKDYILKRTPIHAAATNGHSECLRLLIGNAEPQNAVDIQDG 651

Query: 872 GGWTPMIWATEYKHVDLVKLLLSKGSDINIRDNEENICLHWAAFSGCVDIAEILL--AAK 929
            G TP++ +    H D V  LL+KG++++ +D      LH  A +G  +  + LL   AK
Sbjct: 652 NGQTPLMLSVLNGHTDCVYSLLNKGANVDAKDKWGRTALHRGAVTGHEECVDALLQHGAK 711

Query: 930 CDLHAVNIHGDSPLHIAARENRYDCVVLFL----SRDSDVTLKNKEGETPLQCASLN 982
           C L   +  G +P+H++A       +   L    S D++    +  G T L  A  N
Sbjct: 712 CLLR--DSRGRTPIHLSAACGHIGVLGALLQSAASMDANPATADNHGYTALHWACYN 766



 Score = 98.6 bits (244), Expect = 3e-20
 Identities = 76/237 (32%), Positives = 116/237 (48%), Gaps = 8/237 (3%)

Query: 755 LLMLVDGIDPNFKMEHQ--NKRSPLHAAAEAGHVDICHMLVQAGANIDTCSEDQRTPLME 812
           L +L+   +P   ++ Q  N ++PL  +   GH D  + L+  GAN+D   +  RT L  
Sbjct: 633 LRLLIGNAEPQNAVDIQDGNGQTPLMLSVLNGHTDCVYSLLNKGANVDAKDKWGRTALHR 692

Query: 813 AAENNHLEAVKYLIKAGALVDPKDAEGSTCLHLAAKKGHYEVVQYLL-SNGQMDVN--CQ 869
            A   H E V  L++ GA    +D+ G T +HL+A  GH  V+  LL S   MD N    
Sbjct: 693 GAVTGHEECVDALLQHGAKCLLRDSRGRTPIHLSAACGHIGVLGALLQSAASMDANPATA 752

Query: 870 DDGGWTPMIWATEYKHVDLVKLLLSKGSDINIRDNEENICLHWAAFSGCVDIAEILL--A 927
           D+ G+T + WA    H   V+LLL +        N  +  LH A  +     AE+L+   
Sbjct: 753 DNHGYTALHWACYNGHETCVELLLEQEVFQKTEGNAFS-PLHCAVINDNEGAAEMLIDTL 811

Query: 928 AKCDLHAVNIHGDSPLHIAARENRYDCVVLFLSRDSDVTLKNKEGETPLQCASLNSQ 984
               ++A +  G +PLH AA  +  +C+ L LS ++ V   +  G+TPL  A+ N Q
Sbjct: 812 GASIVNATDSKGRTPLHAAAFTDHVECLQLLLSHNAQVNSVDSTGKTPLMMAAENGQ 868



 Score = 94.4 bits (233), Expect = 6e-19
 Identities = 73/247 (29%), Positives = 115/247 (46%), Gaps = 13/247 (5%)

Query: 784  GHVDICHMLVQAGANIDTCSEDQRTPLMEAAENNHLEAVKYLIKAGALVDPKDAEGSTCL 843
            G  D    L+    +++    ++RTPL  AA     E ++ LI +GA V+ KD++  T L
Sbjct: 19   GDPDEVRALIFKKEDVNFQDNEKRTPLHAAAYLGDAEIIELLILSGARVNAKDSKWLTPL 78

Query: 844  HLAAKKGHYEVVQYLLSNGQMDVNCQDDGGWTPMIWATEYKHVDLVKLLLSKGSDINIRD 903
            H A      E VQ LL +   DVN +D    TP+  A   K V   + L+   S++N+ D
Sbjct: 79   HRAVASCSEEAVQVLLKHSA-DVNARDKNWQTPLHIAAANKAVKCAEALVPLLSNVNVSD 137

Query: 904  NEENICLHWAAFSGCVDIAEILLAAKCDLHAVNIHGDSPLHIAARENRYDCVVLFLSRDS 963
                  LH AAFSG  ++ ++LL+   +++A +      +H AA     + V L +S  +
Sbjct: 138  RAGRTALHHAAFSGHGEMVKLLLSRGANINAFDKKDRRAIHWAAYMGHIEVVKLLVSHGA 197

Query: 964  DVTLKNKEGETPLQCASLNSQVWSALQMSKALQDSAPDRPSPVERIVSRDIARGYERIPI 1023
            +VT K+K+  TPL  A+ +  +     + K L D   D   P         A G   + +
Sbjct: 198  EVTCKDKKSYTPLHAAASSGMI----SVVKYLLDLGVDMNEP--------NAYGNTPLHV 245

Query: 1024 PCVNAVD 1030
             C N  D
Sbjct: 246  ACYNGQD 252



 Score = 92.0 bits (227), Expect = 3e-18
 Identities = 74/257 (28%), Positives = 121/257 (47%), Gaps = 16/257 (6%)

Query: 742 LYFSARQGELQKVLLMLVDGIDPNFKMEHQNKRSPLHAAAEAGHVDICHMLVQAGANIDT 801
           L+ +AR G    +  ++  G D   +  H     PLH AA +G  D C  L+ +G +IDT
Sbjct: 343 LHIAARYGHELLINTLITSGADTAKRGIHG--MFPLHLAALSGFSDCCRKLLSSGFDIDT 400

Query: 802 CSEDQRTPLMEAAENNHLEAVKYLIKAGALVDPKDAEGSTCLHLAAKKGHYEVVQYLLSN 861
             +  RT L  AA   +LE +  L+  GA  + KD  G + LH AA   +Y+ +  L+ +
Sbjct: 401 PDDFGRTCLHAAAAGGNLECLNLLLNTGADFNKKDKFGRSPLHYAAANCNYQCLFALVGS 460

Query: 862 GQMDVNCQDDGGWTPMIW-ATEYKHVDLVKLLLSKGSDINIRDNEENICLHWAAFSG--- 917
           G   VN  D+ G TP+ + AT       ++ LL   ++  IRD +    +H++A  G   
Sbjct: 461 G-ASVNDLDERGCTPLHYAATSDTDGKCLEYLLRNDANPGIRDKQGYNAVHYSAAYGHRL 519

Query: 918 CVDI--AEILLAAKCDLHAVNIHGD-------SPLHIAARENRYDCVVLFLSRDSDVTLK 968
           C+ +  +E  L    +    ++  D       SPLH+AA    +  + + +    D+ ++
Sbjct: 520 CLQLIASETPLDVLMETSGTDMLSDSDNRATISPLHLAAYHGHHQALEVLVQSLLDLDVR 579

Query: 969 NKEGETPLQCASLNSQV 985
           N  G TPL  A+    V
Sbjct: 580 NSSGRTPLDLAAFKGHV 596



 Score = 87.8 bits (216), Expect = 6e-17
 Identities = 71/260 (27%), Positives = 113/260 (43%), Gaps = 43/260 (16%)

Query: 774 RSPLHAAAEAGHVDICHMLVQAGANID----TCSEDQRTPLMEAAENNHLEAVKYLIK-- 827
           R+P+H +A  GH+ +   L+Q+ A++D    T      T L  A  N H   V+ L++  
Sbjct: 720 RTPIHLSAACGHIGVLGALLQSAASMDANPATADNHGYTALHWACYNGHETCVELLLEQE 779

Query: 828 --------------------------------AGALVDPKDAEGSTCLHLAAKKGHYEVV 855
                                             ++V+  D++G T LH AA   H E +
Sbjct: 780 VFQKTEGNAFSPLHCAVINDNEGAAEMLIDTLGASIVNATDSKGRTPLHAAAFTDHVECL 839

Query: 856 QYLLSNGQMDVNCQDDGGWTPMIWATEYKHVDLVKLLLSKGS-DINIRDNEENICLHWAA 914
           Q LLS+    VN  D  G TP++ A E    + V++L+S  S ++ ++DN +N  LH A 
Sbjct: 840 QLLLSHNAQ-VNSVDSTGKTPLMMAAENGQTNTVEMLVSSASAELTLQDNSKNTALHLAC 898

Query: 915 FSGCVDIAEILLAAKCD---LHAVNIHGDSPLHIAARENRYDCVVLFLSRDSDVTLKNKE 971
             G    A ++L    D   ++A N    +PLH+AAR      V   L + + V   ++ 
Sbjct: 899 SKGHETSALLILEKITDRNLINATNAALQTPLHVAARNGLTMVVQELLGKGASVLAVDEN 958

Query: 972 GETPLQCASLNSQVWSALQM 991
           G TP    + N  V   L +
Sbjct: 959 GYTPALACAPNKDVADCLAL 978



 Score = 77.8 bits (190), Expect = 6e-14
 Identities = 70/248 (28%), Positives = 116/248 (46%), Gaps = 14/248 (5%)

Query: 742 LYFSARQGELQKVLLMLVDGIDPNFKMEHQNKRSPLHAAAEAGHVDICHMLVQA-GANID 800
           L+++   G    V L+L   +   F+    N  SPLH A    +     ML+   GA+I 
Sbjct: 760 LHWACYNGHETCVELLLEQEV---FQKTEGNAFSPLHCAVINDNEGAAEMLIDTLGASIV 816

Query: 801 TCSEDQ-RTPLMEAAENNHLEAVKYLIKAGALVDPKDAEGSTCLHLAAKKGHYEVVQYLL 859
             ++ + RTPL  AA  +H+E ++ L+   A V+  D+ G T L +AA+ G    V+ L+
Sbjct: 817 NATDSKGRTPLHAAAFTDHVECLQLLLSHNAQVNSVDSTGKTPLMMAAENGQTNTVEMLV 876

Query: 860 SNGQMDVNCQDDGGWTPMIWATEYKHVDLVKLLLSKGSD---INIRDNEENICLHWAAFS 916
           S+   ++  QD+   T +  A    H     L+L K +D   IN  +      LH AA +
Sbjct: 877 SSASAELTLQDNSKNTALHLACSKGHETSALLILEKITDRNLINATNAALQTPLHVAARN 936

Query: 917 GCVDIAEILLAAKCDLHAVNIHGDSP-LHIAARENRYDCVVLFLSRDSDVTLKNKEGETP 975
           G   + + LL     + AV+ +G +P L  A  ++  DC+ L L+     T+      +P
Sbjct: 937 GLTMVVQELLGKGASVLAVDENGYTPALACAPNKDVADCLALILA-----TMMPVSSSSP 991

Query: 976 LQCASLNS 983
           L   + N+
Sbjct: 992 LSSLTFNA 999



 Score = 73.2 bits (178), Expect = 2e-12
 Identities = 73/304 (24%), Positives = 128/304 (42%), Gaps = 51/304 (16%)

Query: 695 GFDPTGPAGLGRPTPGLSQGPGKETLESALIALDSEKPKKLRFHPKQLYFSARQGELQKV 754
           GFD   P   GR                                   L+ +A  G L+ +
Sbjct: 395 GFDIDTPDDFGRTC---------------------------------LHAAAAGGNLECL 421

Query: 755 LLMLVDGIDPNFKMEHQNKRSPLHAAAEAGHVDICHMLVQAGANIDTCSEDQRTPLMEAA 814
            L+L  G D  F  + +  RSPLH AA   +      LV +GA+++   E   TPL  AA
Sbjct: 422 NLLLNTGAD--FNKKDKFGRSPLHYAAANCNYQCLFALVGSGASVNDLDERGCTPLHYAA 479

Query: 815 -ENNHLEAVKYLIKAGALVDPKDAEGSTCLHLAAKKGHYEVVQYLLSNGQMDVNCQDDG- 872
             +   + ++YL++  A    +D +G   +H +A  GH   +Q + S   +DV  +  G 
Sbjct: 480 TSDTDGKCLEYLLRNDANPGIRDKQGYNAVHYSAAYGHRLCLQLIASETPLDVLMETSGT 539

Query: 873 ----------GWTPMIWATEYKHVDLVKLLLSKGSDINIRDNEENICLHWAAFSGCVDIA 922
                       +P+  A  + H   +++L+    D+++R++     L  AAF G V+  
Sbjct: 540 DMLSDSDNRATISPLHLAAYHGHHQALEVLVQSLLDLDVRNSSGRTPLDLAAFKGHVECV 599

Query: 923 EILLAAKCDLHAVN-IHGDSPLHIAARENRYDCVVLFLSR---DSDVTLKNKEGETPLQC 978
           ++L+     +   + I   +P+H AA     +C+ L +      + V +++  G+TPL  
Sbjct: 600 DVLINQGASILVKDYILKRTPIHAAATNGHSECLRLLIGNAEPQNAVDIQDGNGQTPLML 659

Query: 979 ASLN 982
           + LN
Sbjct: 660 SVLN 663


>gi|13376842 tankyrase, TRF1-interacting ankyrin-related ADP-ribose
           polymerase 2 [Homo sapiens]
          Length = 1166

 Score =  115 bits (289), Expect = 2e-25
 Identities = 87/261 (33%), Positives = 130/261 (49%), Gaps = 26/261 (9%)

Query: 742 LYFSARQGELQKVLLMLVDGIDPNFKMEHQNKRSPLHAAAEAGHVDICHMLVQAGANIDT 801
           L+F+A    +  V  +L  G D + K   +    PLH A   GH ++  +LV+ GA ++ 
Sbjct: 530 LHFAAGYNRVSVVEYLLQHGADVHAK--DKGGLVPLHNACSYGHYEVAELLVKHGAVVNV 587

Query: 802 CSEDQRTPLMEAAENNHLEAVKYLIKAGALVDPKDAEGSTCLHL---------------- 845
               + TPL EAA     E  K L++ GA    K+ +G+T L L                
Sbjct: 588 ADLWKFTPLHEAAAKGKYEICKLLLQHGADPTKKNRDGNTPLDLVKDGDTDIQDLLRGDA 647

Query: 846 ----AAKKGHYEVVQYLLSNGQMDVNCQDDGGW--TPMIWATEYKHVDLVKLLLSKGSDI 899
               AAKKG    V+ L S    +VNC+D  G   TP+  A  Y ++++ + LL  G+D+
Sbjct: 648 ALLDAAKKGCLARVKKLSSPD--NVNCRDTQGRHSTPLHLAAGYNNLEVAEYLLQHGADV 705

Query: 900 NIRDNEENICLHWAAFSGCVDIAEILLAAKCDLHAVNIHGDSPLHIAARENRYDCVVLFL 959
           N +D    I LH AA  G VD+A +L+     ++A +    +PLH AA++ R     L L
Sbjct: 706 NAQDKGGLIPLHNAASYGHVDVAALLIKYNACVNATDKWAFTPLHEAAQKGRTQLCALLL 765

Query: 960 SRDSDVTLKNKEGETPLQCAS 980
           +  +D TLKN+EG+TPL   S
Sbjct: 766 AHGADPTLKNQEGQTPLDLVS 786



 Score = 97.1 bits (240), Expect = 1e-19
 Identities = 82/298 (27%), Positives = 131/298 (43%), Gaps = 64/298 (21%)

Query: 765 NFKMEHQNKRSPLHAAAEAGHV---DICHMLVQAGANIDTCSEDQRTPLMEAAENNHLEA 821
           NFK   Q   + LH AA + +     IC +L++ GANI+  +++  TPL  A+E  H + 
Sbjct: 357 NFK-HPQTHETALHCAAASPYPKRKQICELLLRKGANINEKTKEFLTPLHVASEKAHNDV 415

Query: 822 VKYLIKAGALVDPKDAEGSTCLHLAAKKGHYEVVQYL----------------------- 858
           V+ ++K  A V+  D  G T LH AA  GH +  + L                       
Sbjct: 416 VEVVVKHEAKVNALDNLGQTSLHRAAYCGHLQTCRLLLSYGCDPNIISLQGFTALQMGNE 475

Query: 859 -----------LSNGQMD-----------------------VNCQDDGGW--TPMIWATE 882
                      L N + D                       VNC+D  G   TP+ +A  
Sbjct: 476 NVQQLLQEGISLGNSEADRQLLEAAKAGDVETVKKLCTVQSVNCRDIEGRQSTPLHFAAG 535

Query: 883 YKHVDLVKLLLSKGSDINIRDNEENICLHWAAFSGCVDIAEILLAAKCDLHAVNIHGDSP 942
           Y  V +V+ LL  G+D++ +D    + LH A   G  ++AE+L+     ++  ++   +P
Sbjct: 536 YNRVSVVEYLLQHGADVHAKDKGGLVPLHNACSYGHYEVAELLVKHGAVVNVADLWKFTP 595

Query: 943 LHIAARENRYDCVVLFLSRDSDVTLKNKEGETPLQCA-SLNSQVWSALQMSKALQDSA 999
           LH AA + +Y+   L L   +D T KN++G TPL      ++ +   L+   AL D+A
Sbjct: 596 LHEAAAKGKYEICKLLLQHGADPTKKNRDGNTPLDLVKDGDTDIQDLLRGDAALLDAA 653



 Score = 96.3 bits (238), Expect = 2e-19
 Identities = 79/293 (26%), Positives = 126/293 (43%), Gaps = 54/293 (18%)

Query: 740 KQLYFSARQGELQKVLLMLVDGIDPNFKMEHQNKRSPLHAAAEAGHVDICHMLVQAGANI 799
           ++L+ + R G++++V   LV     N +     K +PLH AA  G  D+   L+Q GAN+
Sbjct: 26  RELFEACRNGDVERVK-RLVTPEKVNSRDTAGRKSTPLHFAAGFGRKDVVEYLLQNGANV 84

Query: 800 DTCSEDQRTPLMEAAENNHLEAVKYLIKAGALVDPKDAEGSTCLHLAAKKGHYEVVQYLL 859
               +    PL  A    H E V  L++ GA  + +D    T LH AA KG  +V   LL
Sbjct: 85  QARDDGGLIPLHNACSFGHAEVVNLLLRHGADPNARDNWNYTPLHEAAIKGKIDVCIVLL 144

Query: 860 SNG---------------------------------------------------QMDVNC 868
            +G                                                    ++VNC
Sbjct: 145 QHGAEPTIRNTDGRTALDLADPSAKAVLTGEYKKDELLESARSGNEEKMMALLTPLNVNC 204

Query: 869 QDDGG--WTPMIWATEYKHVDLVKLLLSKGSDINIRDNEENICLHWAAFSGCVDIAEILL 926
               G   TP+  A  Y  V +V+LLL  G+D++ +D  + + LH A   G  ++ E+L+
Sbjct: 205 HASDGRKSTPLHLAAGYNRVKIVQLLLQHGADVHAKDKGDLVPLHNACSYGHYEVTELLV 264

Query: 927 AAKCDLHAVNIHGDSPLHIAARENRYDCVVLFLSRDSDVTLKNKEGETPLQCA 979
                ++A+++   +PLH AA +NR +   L LS  +D TL N   ++ +  A
Sbjct: 265 KHGACVNAMDLWQFTPLHEAASKNRVEVCSLLLSYGADPTLLNCHNKSAIDLA 317



 Score = 92.0 bits (227), Expect = 3e-18
 Identities = 69/200 (34%), Positives = 96/200 (48%), Gaps = 24/200 (12%)

Query: 773 KRSPLHAAAEAGHVDICHMLVQAGANIDTCSEDQRTPL--------------------ME 812
           K +PLH AA  G  +IC +L+Q GA+    + D  TPL                    ++
Sbjct: 592 KFTPLHEAAAKGKYEICKLLLQHGADPTKKNRDGNTPLDLVKDGDTDIQDLLRGDAALLD 651

Query: 813 AAENNHLEAVKYLIKAGALVDPKDAEG--STCLHLAAKKGHYEVVQYLLSNGQMDVNCQD 870
           AA+   L  VK L      V+ +D +G  ST LHLAA   + EV +YLL +G  DVN QD
Sbjct: 652 AAKKGCLARVKKLSSPDN-VNCRDTQGRHSTPLHLAAGYNNLEVAEYLLQHGA-DVNAQD 709

Query: 871 DGGWTPMIWATEYKHVDLVKLLLSKGSDINIRDNEENICLHWAAFSGCVDIAEILLAAKC 930
            GG  P+  A  Y HVD+  LL+   + +N  D      LH AA  G   +  +LLA   
Sbjct: 710 KGGLIPLHNAASYGHVDVAALLIKYNACVNATDKWAFTPLHEAAQKGRTQLCALLLAHGA 769

Query: 931 DLHAVNIHGDSPLHIAAREN 950
           D    N  G +PL + + ++
Sbjct: 770 DPTLKNQEGQTPLDLVSADD 789



 Score = 84.3 bits (207), Expect = 7e-16
 Identities = 69/206 (33%), Positives = 107/206 (51%), Gaps = 13/206 (6%)

Query: 742 LYFSARQGELQKVLLMLVDGIDPNFKMEHQNKRSPLHAAAEAGHVDICHMLVQAGANIDT 801
           L+ +A  G LQ   L+L  G DPN  +  Q        A + G+ ++   L+Q G ++  
Sbjct: 437 LHRAAYCGHLQTCRLLLSYGCDPNI-ISLQG-----FTALQMGNENV-QQLLQEGISLGN 489

Query: 802 CSEDQRTPLMEAAENNHLEAVKYLIKAGALVDPKDAEG--STCLHLAAKKGHYEVVQYLL 859
              D++  L+EAA+   +E VK L    + V+ +D EG  ST LH AA      VV+YLL
Sbjct: 490 SEADRQ--LLEAAKAGDVETVKKLCTVQS-VNCRDIEGRQSTPLHFAAGYNRVSVVEYLL 546

Query: 860 SNGQMDVNCQDDGGWTPMIWATEYKHVDLVKLLLSKGSDINIRDNEENICLHWAAFSGCV 919
            +G  DV+ +D GG  P+  A  Y H ++ +LL+  G+ +N+ D  +   LH AA  G  
Sbjct: 547 QHG-ADVHAKDKGGLVPLHNACSYGHYEVAELLVKHGAVVNVADLWKFTPLHEAAAKGKY 605

Query: 920 DIAEILLAAKCDLHAVNIHGDSPLHI 945
           +I ++LL    D    N  G++PL +
Sbjct: 606 EICKLLLQHGADPTKKNRDGNTPLDL 631



 Score = 70.5 bits (171), Expect = 1e-11
 Identities = 82/314 (26%), Positives = 131/314 (41%), Gaps = 28/314 (8%)

Query: 742  LYFSARQGELQKVLLMLVDGIDPNFKMEHQNKRSPLHAAAEAGHVDICHMLVQAGANIDT 801
            L+ +A    ++ V L+L  G D + K   +    PLH A   GH ++  +LV+ GA ++ 
Sbjct: 215  LHLAAGYNRVKIVQLLLQHGADVHAK--DKGDLVPLHNACSYGHYEVTELLVKHGACVNA 272

Query: 802  CSEDQRTPLMEAAENNHLEAVKYLIKAGALVDPKDAEGSTCLHLAAKKGHYEVVQY---- 857
                Q TPL EAA  N +E    L+  GA     +    + + LA      E + Y    
Sbjct: 273  MDLWQFTPLHEAASKNRVEVCSLLLSYGADPTLLNCHNKSAIDLAPTPQLKERLAYEFKG 332

Query: 858  ---LLSNGQMDVNCQDDGGWTPMI---------------WATEY-KHVDLVKLLLSKGSD 898
               L +  + DV          M+                A+ Y K   + +LLL KG++
Sbjct: 333  HSLLQAAREADVTRIKKHLSLEMVNFKHPQTHETALHCAAASPYPKRKQICELLLRKGAN 392

Query: 899  INIRDNEENICLHWAAFSGCVDIAEILLAAKCDLHAVNIHGDSPLHIAARENRYDCVVLF 958
            IN +  E    LH A+     D+ E+++  +  ++A++  G + LH AA         L 
Sbjct: 393  INEKTKEFLTPLHVASEKAHNDVVEVVVKHEAKVNALDNLGQTSLHRAAYCGHLQTCRLL 452

Query: 959  LSRDSDVTLKNKEGETPLQCASLNSQVWSALQMSKALQDSAPDRPSPVERIVSRDIARGY 1018
            LS   D  + + +G T LQ    N  V   LQ   +L +S  DR   +E   + D+    
Sbjct: 453  LSYGCDPNIISLQGFTALQMG--NENVQQLLQEGISLGNSEADR-QLLEAAKAGDVETVK 509

Query: 1019 ERIPIPCVNAVDSE 1032
            +   +  VN  D E
Sbjct: 510  KLCTVQSVNCRDIE 523



 Score = 61.2 bits (147), Expect = 6e-09
 Identities = 46/154 (29%), Positives = 77/154 (50%), Gaps = 8/154 (5%)

Query: 828 AGALVDPKDAEGSTCLHLAAKKGHYEVVQYLLSNGQMDVNCQDDGGW--TPMIWATEYKH 885
           A   V+P   E    L  A + G  E V+ L++  +  VN +D  G   TP+ +A  +  
Sbjct: 17  AAEAVEPAARE----LFEACRNGDVERVKRLVTPEK--VNSRDTAGRKSTPLHFAAGFGR 70

Query: 886 VDLVKLLLSKGSDINIRDNEENICLHWAAFSGCVDIAEILLAAKCDLHAVNIHGDSPLHI 945
            D+V+ LL  G+++  RD+   I LH A   G  ++  +LL    D +A +    +PLH 
Sbjct: 71  KDVVEYLLQNGANVQARDDGGLIPLHNACSFGHAEVVNLLLRHGADPNARDNWNYTPLHE 130

Query: 946 AARENRYDCVVLFLSRDSDVTLKNKEGETPLQCA 979
           AA + + D  ++ L   ++ T++N +G T L  A
Sbjct: 131 AAIKGKIDVCIVLLQHGAEPTIRNTDGRTALDLA 164


>gi|52426737 ankyrin 2 isoform 2 [Homo sapiens]
          Length = 1872

 Score =  115 bits (288), Expect = 3e-25
 Identities = 87/288 (30%), Positives = 136/288 (47%), Gaps = 41/288 (14%)

Query: 730 EKPKKLRFHPKQLYFSARQGELQKVLLMLVDGIDPNFKMEHQNKRSPLHAAAEAGHVDIC 789
           ++PKK   +   L  +AR G L KV+  L  GID N    +QN  + LH AA+ GHV + 
Sbjct: 24  KRPKKSDSNASFLR-AARAGNLDKVVEYLKGGIDINTC--NQNGLNALHLAAKEGHVGLV 80

Query: 790 HMLVQAGANIDTCSEDQRTPLMEAAENNHLEAVKYLIKAGALVDPKDAEGSTCLHLAAKK 849
             L+  G+++D+ ++   T L  A+     E VK L+K GA ++ +   G T L++AA++
Sbjct: 81  QELLGRGSSVDSATKKGNTALHIASLAGQAEVVKVLVKEGANINAQSQNGFTPLYMAAQE 140

Query: 850 GHYEVVQYLLSNGQMDVNCQDDGGWTPMIWATEYKHVDLVKLLLSKGSDINIR------- 902
            H +VV+YLL NG       +D G+TP+  A +  H   V +LL   +   +R       
Sbjct: 141 NHIDVVKYLLENGANQSTATED-GFTPLAVALQQGHNQAVAILLENDTKGKVRLPALHIA 199

Query: 903 -------------DNEEN-----------------ICLHWAAFSGCVDIAEILLAAKCDL 932
                         N+ N                   LH AA  G V++A +LL     +
Sbjct: 200 ARKDDTKSAALLLQNDHNADVQSKMMVNRTTESGFTPLHIAAHYGNVNVATLLLNRGAAV 259

Query: 933 HAVNIHGDSPLHIAARENRYDCVVLFLSRDSDVTLKNKEGETPLQCAS 980
                +G +PLH+A++    + V L L R   +  K ++G TPL CA+
Sbjct: 260 DFTARNGITPLHVASKRGNTNMVKLLLDRGGQIDAKTRDGLTPLHCAA 307



 Score =  111 bits (278), Expect = 4e-24
 Identities = 74/266 (27%), Positives = 137/266 (51%), Gaps = 9/266 (3%)

Query: 721 ESALIALDSEKPKKLRFHPKQLYFSARQGELQKVLLMLVDGIDPNFKMEHQNKRS----- 775
           ++  I L+++   K+R     L+ +AR+ + +   L+L +  + + + +    R+     
Sbjct: 177 QAVAILLENDTKGKVRL--PALHIAARKDDTKSAALLLQNDHNADVQSKMMVNRTTESGF 234

Query: 776 -PLHAAAEAGHVDICHMLVQAGANIDTCSEDQRTPLMEAAENNHLEAVKYLIKAGALVDP 834
            PLH AA  G+V++  +L+  GA +D  + +  TPL  A++  +   VK L+  G  +D 
Sbjct: 235 TPLHIAAHYGNVNVATLLLNRGAAVDFTARNGITPLHVASKRGNTNMVKLLLDRGGQIDA 294

Query: 835 KDAEGSTCLHLAAKKGHYEVVQYLLSNGQMDVNCQDDGGWTPMIWATEYKHVDLVKLLLS 894
           K  +G T LH AA+ GH +VV+ LL  G   +  +   G +P+  A +  HV+ VK LL 
Sbjct: 295 KTRDGLTPLHCAARSGHDQVVELLLERG-APLLARTKNGLSPLHMAAQGDHVECVKHLLQ 353

Query: 895 KGSDINIRDNEENICLHWAAFSGCVDIAEILLAAKCDLHAVNIHGDSPLHIAARENRYDC 954
             + ++    +    LH AA  G   + ++LL  + + +A  ++G +PLHIA ++NR   
Sbjct: 354 HKAPVDDVTLDYLTALHVAAHCGHYRVTKLLLDKRANPNARALNGFTPLHIACKKNRIKV 413

Query: 955 VVLFLSRDSDVTLKNKEGETPLQCAS 980
           + L +   + +    + G TP+  A+
Sbjct: 414 MELLVKYGASIQAITESGLTPIHVAA 439



 Score =  109 bits (272), Expect = 2e-23
 Identities = 79/266 (29%), Positives = 129/266 (48%), Gaps = 16/266 (6%)

Query: 742  LYFSARQGELQKVLLMLVDGIDPNFKMEHQNKRSPLHAAAEAGHVDICHMLVQAGANIDT 801
            L+ ++  G+ + V +++ +G   N   + QN  +PL+ AA+  H+D+   L++ GAN  T
Sbjct: 101  LHIASLAGQAEVVKVLVKEGA--NINAQSQNGFTPLYMAAQENHIDVVKYLLENGANQST 158

Query: 802  CSEDQRTPLMEAAENNHLEAVKYLIKAGALVDPKDAEGSTCLHLAAKKGHYEVVQYLLSN 861
             +ED  TPL  A +  H +AV  L++     D K       LH+AA+K   +    LL N
Sbjct: 159  ATEDGFTPLAVALQQGHNQAVAILLEN----DTKGKVRLPALHIAARKDDTKSAALLLQN 214

Query: 862  -------GQMDVNCQDDGGWTPMIWATEYKHVDLVKLLLSKGSDINIRDNEENICLHWAA 914
                    +M VN   + G+TP+  A  Y +V++  LLL++G+ ++         LH A+
Sbjct: 215  DHNADVQSKMMVNRTTESGFTPLHIAAHYGNVNVATLLLNRGAAVDFTARNGITPLHVAS 274

Query: 915  FSGCVDIAEILLAAKCDLHAVNIHGDSPLHIAARENRYDCVVLFLSRDSDVTLKNKEGET 974
              G  ++ ++LL     + A    G +PLH AAR      V L L R + +  + K G +
Sbjct: 275  KRGNTNMVKLLLDRGGQIDAKTRDGLTPLHCAARSGHDQVVELLLERGAPLLARTKNGLS 334

Query: 975  PLQCASLNSQVWSALQMSKALQDSAP 1000
            PL  A+    V     +   LQ  AP
Sbjct: 335  PLHMAAQGDHVECVKHL---LQHKAP 357



 Score =  108 bits (271), Expect = 3e-23
 Identities = 77/239 (32%), Positives = 116/239 (48%), Gaps = 3/239 (1%)

Query: 742 LYFSARQGELQKVLLMLVDGIDPNFKMEHQNKRSPLHAAAEAGHVDICHMLVQAGANIDT 801
           L+ +A  G  +   L+L    +PN +    N  +PLH A +   + +  +LV+ GA+I  
Sbjct: 369 LHVAAHCGHYRVTKLLLDKRANPNARA--LNGFTPLHIACKKNRIKVMELLVKYGASIQA 426

Query: 802 CSEDQRTPLMEAAENNHLEAVKYLIKAGALVDPKDAEGSTCLHLAAKKGHYEVVQYLLSN 861
            +E   TP+  AA   HL  V  L++ GA  D  +  G T LH+AA+ G  EVV+ LL N
Sbjct: 427 ITESGLTPIHVAAFMGHLNIVLLLLQNGASPDVTNIRGETALHMAARAGQVEVVRCLLRN 486

Query: 862 GQMDVNCQDDGGWTPMIWATEYKHVDLVKLLLSKGSDINIRDNEENICLHWAAFSGCVDI 921
           G + V+ +     TP+  A+     ++V+LLL   +  +         LH +A  G VD+
Sbjct: 487 GAL-VDARAREEQTPLHIASRLGKTEIVQLLLQHMAHPDAATTNGYTPLHISAREGQVDV 545

Query: 922 AEILLAAKCDLHAVNIHGDSPLHIAARENRYDCVVLFLSRDSDVTLKNKEGETPLQCAS 980
           A +LL A          G +PLH+AA+    D   L L R +      K G TPL  A+
Sbjct: 546 ASVLLEAGAAHSLATKKGFTPLHVAAKYGSLDVAKLLLQRRAAADSAGKNGLTPLHVAA 604



 Score =  108 bits (269), Expect = 4e-23
 Identities = 75/239 (31%), Positives = 120/239 (50%), Gaps = 3/239 (1%)

Query: 742 LYFSARQGELQKVLLMLVDGIDPNFKMEHQNKRSPLHAAAEAGHVDICHMLVQAGANIDT 801
           L+ SAR+G++    ++L  G   +  +  +   +PLH AA+ G +D+  +L+Q  A  D+
Sbjct: 534 LHISAREGQVDVASVLLEAGAAHS--LATKKGFTPLHVAAKYGSLDVAKLLLQRRAAADS 591

Query: 802 CSEDQRTPLMEAAENNHLEAVKYLIKAGALVDPKDAEGSTCLHLAAKKGHYEVVQYLLSN 861
             ++  TPL  AA  ++ +    L++ GA        G T LH+AAKK   ++   LL+ 
Sbjct: 592 AGKNGLTPLHVAAHYDNQKVALLLLEKGASPHATAKNGYTPLHIAAKKNQMQIASTLLNY 651

Query: 862 GQMDVNCQDDGGWTPMIWATEYKHVDLVKLLLSKGSDINIRDNEENICLHWAAFSGCVDI 921
           G  + N     G TP+  A++  H D+V LLL KG++I++        LH AA    V++
Sbjct: 652 GA-ETNIVTKQGVTPLHLASQEGHTDMVTLLLDKGANIHMSTKSGLTSLHLAAQEDKVNV 710

Query: 922 AEILLAAKCDLHAVNIHGDSPLHIAARENRYDCVVLFLSRDSDVTLKNKEGETPLQCAS 980
           A+IL     D  A    G +PL +A        V   L + ++V  K K G TPL  A+
Sbjct: 711 ADILTKHGADQDAHTKLGYTPLIVACHYGNVKMVNFLLKQGANVNAKTKNGYTPLHQAA 769



 Score =  103 bits (257), Expect = 1e-21
 Identities = 73/246 (29%), Positives = 121/246 (49%), Gaps = 7/246 (2%)

Query: 742 LYFSARQGELQKVLLMLVDG--IDPNFKMEHQNKRSPLHAAAEAGHVDICHMLVQAGANI 799
           L+ +AR G+++ V  +L +G  +D   + E    ++PLH A+  G  +I  +L+Q  A+ 
Sbjct: 468 LHMAARAGQVEVVRCLLRNGALVDARAREE----QTPLHIASRLGKTEIVQLLLQHMAHP 523

Query: 800 DTCSEDQRTPLMEAAENNHLEAVKYLIKAGALVDPKDAEGSTCLHLAAKKGHYEVVQYLL 859
           D  + +  TPL  +A    ++    L++AGA       +G T LH+AAK G  +V + LL
Sbjct: 524 DAATTNGYTPLHISAREGQVDVASVLLEAGAAHSLATKKGFTPLHVAAKYGSLDVAKLLL 583

Query: 860 SNGQMDVNCQDDGGWTPMIWATEYKHVDLVKLLLSKGSDINIRDNEENICLHWAAFSGCV 919
              +   +     G TP+  A  Y +  +  LLL KG+  +         LH AA    +
Sbjct: 584 QR-RAAADSAGKNGLTPLHVAAHYDNQKVALLLLEKGASPHATAKNGYTPLHIAAKKNQM 642

Query: 920 DIAEILLAAKCDLHAVNIHGDSPLHIAARENRYDCVVLFLSRDSDVTLKNKEGETPLQCA 979
            IA  LL    + + V   G +PLH+A++E   D V L L + +++ +  K G T L  A
Sbjct: 643 QIASTLLNYGAETNIVTKQGVTPLHLASQEGHTDMVTLLLDKGANIHMSTKSGLTSLHLA 702

Query: 980 SLNSQV 985
           +   +V
Sbjct: 703 AQEDKV 708



 Score =  100 bits (248), Expect = 1e-20
 Identities = 79/270 (29%), Positives = 120/270 (44%), Gaps = 3/270 (1%)

Query: 716 GKETLESALIALDSEKPKKLRFHPKQLYFSARQGELQKVLLMLVDGIDPNFKMEHQNKRS 775
           G   +   L+    +   K R     L+ +AR G  Q V L+L  G         +N  S
Sbjct: 277 GNTNMVKLLLDRGGQIDAKTRDGLTPLHCAARSGHDQVVELLLERGAP--LLARTKNGLS 334

Query: 776 PLHAAAEAGHVDICHMLVQAGANIDTCSEDQRTPLMEAAENNHLEAVKYLIKAGALVDPK 835
           PLH AA+  HV+    L+Q  A +D  + D  T L  AA   H    K L+   A  + +
Sbjct: 335 PLHMAAQGDHVECVKHLLQHKAPVDDVTLDYLTALHVAAHCGHYRVTKLLLDKRANPNAR 394

Query: 836 DAEGSTCLHLAAKKGHYEVVQYLLSNGQMDVNCQDDGGWTPMIWATEYKHVDLVKLLLSK 895
              G T LH+A KK   +V++ L+  G   +    + G TP+  A    H+++V LLL  
Sbjct: 395 ALNGFTPLHIACKKNRIKVMELLVKYGA-SIQAITESGLTPIHVAAFMGHLNIVLLLLQN 453

Query: 896 GSDINIRDNEENICLHWAAFSGCVDIAEILLAAKCDLHAVNIHGDSPLHIAARENRYDCV 955
           G+  ++ +      LH AA +G V++   LL     + A      +PLHIA+R  + + V
Sbjct: 454 GASPDVTNIRGETALHMAARAGQVEVVRCLLRNGALVDARAREEQTPLHIASRLGKTEIV 513

Query: 956 VLFLSRDSDVTLKNKEGETPLQCASLNSQV 985
            L L   +        G TPL  ++   QV
Sbjct: 514 QLLLQHMAHPDAATTNGYTPLHISAREGQV 543



 Score = 92.0 bits (227), Expect = 3e-18
 Identities = 63/207 (30%), Positives = 99/207 (47%), Gaps = 3/207 (1%)

Query: 742 LYFSARQGELQKVLLMLVDGIDPNFKMEHQNKRSPLHAAAEAGHVDICHMLVQAGANIDT 801
           L+ +A     +  LL+L  G  P+   +  N  +PLH AA+   + I   L+  GA  + 
Sbjct: 600 LHVAAHYDNQKVALLLLEKGASPHATAK--NGYTPLHIAAKKNQMQIASTLLNYGAETNI 657

Query: 802 CSEDQRTPLMEAAENNHLEAVKYLIKAGALVDPKDAEGSTCLHLAAKKGHYEVVQYLLSN 861
            ++   TPL  A++  H + V  L+  GA +      G T LHLAA++    V   L  +
Sbjct: 658 VTKQGVTPLHLASQEGHTDMVTLLLDKGANIHMSTKSGLTSLHLAAQEDKVNVADILTKH 717

Query: 862 GQMDVNCQDDGGWTPMIWATEYKHVDLVKLLLSKGSDINIRDNEENICLHWAAFSGCVDI 921
           G  D +     G+TP+I A  Y +V +V  LL +G+++N +       LH AA  G   I
Sbjct: 718 GA-DQDAHTKLGYTPLIVACHYGNVKMVNFLLKQGANVNAKTKNGYTPLHQAAQQGHTHI 776

Query: 922 AEILLAAKCDLHAVNIHGDSPLHIAAR 948
             +LL      +A   +G++ L IA R
Sbjct: 777 INVLLQHGAKPNATTANGNTALAIAKR 803



 Score = 77.0 bits (188), Expect = 1e-13
 Identities = 52/184 (28%), Positives = 89/184 (48%), Gaps = 3/184 (1%)

Query: 742 LYFSARQGELQKVLLMLVDGIDPNFKMEHQNKRSPLHAAAEAGHVDICHMLVQAGANIDT 801
           L+ +A++ ++Q    +L  G + N   +     +PLH A++ GH D+  +L+  GANI  
Sbjct: 633 LHIAAKKNQMQIASTLLNYGAETNIVTKQGV--TPLHLASQEGHTDMVTLLLDKGANIHM 690

Query: 802 CSEDQRTPLMEAAENNHLEAVKYLIKAGALVDPKDAEGSTCLHLAAKKGHYEVVQYLLSN 861
            ++   T L  AA+ + +     L K GA  D     G T L +A   G+ ++V +LL  
Sbjct: 691 STKSGLTSLHLAAQEDKVNVADILTKHGADQDAHTKLGYTPLIVACHYGNVKMVNFLLKQ 750

Query: 862 GQMDVNCQDDGGWTPMIWATEYKHVDLVKLLLSKGSDINIRDNEENICLHWAAFSGCVDI 921
           G  +VN +   G+TP+  A +  H  ++ +LL  G+  N      N  L  A   G + +
Sbjct: 751 GA-NVNAKTKNGYTPLHQAAQQGHTHIINVLLQHGAKPNATTANGNTALAIAKRLGYISV 809

Query: 922 AEIL 925
            + L
Sbjct: 810 VDTL 813



 Score = 42.0 bits (97), Expect = 0.004
 Identities = 26/101 (25%), Positives = 49/101 (48%)

Query: 885 HVDLVKLLLSKGSDINIRDNEENICLHWAAFSGCVDIAEILLAAKCDLHAVNIHGDSPLH 944
           ++D V   L  G DIN  +      LH AA  G V + + LL     + +    G++ LH
Sbjct: 43  NLDKVVEYLKGGIDINTCNQNGLNALHLAAKEGHVGLVQELLGRGSSVDSATKKGNTALH 102

Query: 945 IAARENRYDCVVLFLSRDSDVTLKNKEGETPLQCASLNSQV 985
           IA+   + + V + +   +++  +++ G TPL  A+  + +
Sbjct: 103 IASLAGQAEVVKVLVKEGANINAQSQNGFTPLYMAAQENHI 143



 Score = 40.8 bits (94), Expect = 0.009
 Identities = 27/83 (32%), Positives = 39/83 (46%)

Query: 902 RDNEENICLHWAAFSGCVDIAEILLAAKCDLHAVNIHGDSPLHIAARENRYDCVVLFLSR 961
           + ++ N     AA +G +D     L    D++  N +G + LH+AA+E     V   L R
Sbjct: 27  KKSDSNASFLRAARAGNLDKVVEYLKGGIDINTCNQNGLNALHLAAKEGHVGLVQELLGR 86

Query: 962 DSDVTLKNKEGETPLQCASLNSQ 984
            S V    K+G T L  ASL  Q
Sbjct: 87  GSSVDSATKKGNTALHIASLAGQ 109


>gi|52426735 ankyrin 2 isoform 1 [Homo sapiens]
          Length = 3957

 Score =  115 bits (288), Expect = 3e-25
 Identities = 87/288 (30%), Positives = 136/288 (47%), Gaps = 41/288 (14%)

Query: 730 EKPKKLRFHPKQLYFSARQGELQKVLLMLVDGIDPNFKMEHQNKRSPLHAAAEAGHVDIC 789
           ++PKK   +   L  +AR G L KV+  L  GID N    +QN  + LH AA+ GHV + 
Sbjct: 24  KRPKKSDSNASFLR-AARAGNLDKVVEYLKGGIDINTC--NQNGLNALHLAAKEGHVGLV 80

Query: 790 HMLVQAGANIDTCSEDQRTPLMEAAENNHLEAVKYLIKAGALVDPKDAEGSTCLHLAAKK 849
             L+  G+++D+ ++   T L  A+     E VK L+K GA ++ +   G T L++AA++
Sbjct: 81  QELLGRGSSVDSATKKGNTALHIASLAGQAEVVKVLVKEGANINAQSQNGFTPLYMAAQE 140

Query: 850 GHYEVVQYLLSNGQMDVNCQDDGGWTPMIWATEYKHVDLVKLLLSKGSDINIR------- 902
            H +VV+YLL NG       +D G+TP+  A +  H   V +LL   +   +R       
Sbjct: 141 NHIDVVKYLLENGANQSTATED-GFTPLAVALQQGHNQAVAILLENDTKGKVRLPALHIA 199

Query: 903 -------------DNEEN-----------------ICLHWAAFSGCVDIAEILLAAKCDL 932
                         N+ N                   LH AA  G V++A +LL     +
Sbjct: 200 ARKDDTKSAALLLQNDHNADVQSKMMVNRTTESGFTPLHIAAHYGNVNVATLLLNRGAAV 259

Query: 933 HAVNIHGDSPLHIAARENRYDCVVLFLSRDSDVTLKNKEGETPLQCAS 980
                +G +PLH+A++    + V L L R   +  K ++G TPL CA+
Sbjct: 260 DFTARNGITPLHVASKRGNTNMVKLLLDRGGQIDAKTRDGLTPLHCAA 307



 Score =  111 bits (278), Expect = 4e-24
 Identities = 74/266 (27%), Positives = 137/266 (51%), Gaps = 9/266 (3%)

Query: 721 ESALIALDSEKPKKLRFHPKQLYFSARQGELQKVLLMLVDGIDPNFKMEHQNKRS----- 775
           ++  I L+++   K+R     L+ +AR+ + +   L+L +  + + + +    R+     
Sbjct: 177 QAVAILLENDTKGKVRL--PALHIAARKDDTKSAALLLQNDHNADVQSKMMVNRTTESGF 234

Query: 776 -PLHAAAEAGHVDICHMLVQAGANIDTCSEDQRTPLMEAAENNHLEAVKYLIKAGALVDP 834
            PLH AA  G+V++  +L+  GA +D  + +  TPL  A++  +   VK L+  G  +D 
Sbjct: 235 TPLHIAAHYGNVNVATLLLNRGAAVDFTARNGITPLHVASKRGNTNMVKLLLDRGGQIDA 294

Query: 835 KDAEGSTCLHLAAKKGHYEVVQYLLSNGQMDVNCQDDGGWTPMIWATEYKHVDLVKLLLS 894
           K  +G T LH AA+ GH +VV+ LL  G   +  +   G +P+  A +  HV+ VK LL 
Sbjct: 295 KTRDGLTPLHCAARSGHDQVVELLLERG-APLLARTKNGLSPLHMAAQGDHVECVKHLLQ 353

Query: 895 KGSDINIRDNEENICLHWAAFSGCVDIAEILLAAKCDLHAVNIHGDSPLHIAARENRYDC 954
             + ++    +    LH AA  G   + ++LL  + + +A  ++G +PLHIA ++NR   
Sbjct: 354 HKAPVDDVTLDYLTALHVAAHCGHYRVTKLLLDKRANPNARALNGFTPLHIACKKNRIKV 413

Query: 955 VVLFLSRDSDVTLKNKEGETPLQCAS 980
           + L +   + +    + G TP+  A+
Sbjct: 414 MELLVKYGASIQAITESGLTPIHVAA 439



 Score =  109 bits (272), Expect = 2e-23
 Identities = 79/266 (29%), Positives = 129/266 (48%), Gaps = 16/266 (6%)

Query: 742  LYFSARQGELQKVLLMLVDGIDPNFKMEHQNKRSPLHAAAEAGHVDICHMLVQAGANIDT 801
            L+ ++  G+ + V +++ +G   N   + QN  +PL+ AA+  H+D+   L++ GAN  T
Sbjct: 101  LHIASLAGQAEVVKVLVKEGA--NINAQSQNGFTPLYMAAQENHIDVVKYLLENGANQST 158

Query: 802  CSEDQRTPLMEAAENNHLEAVKYLIKAGALVDPKDAEGSTCLHLAAKKGHYEVVQYLLSN 861
             +ED  TPL  A +  H +AV  L++     D K       LH+AA+K   +    LL N
Sbjct: 159  ATEDGFTPLAVALQQGHNQAVAILLEN----DTKGKVRLPALHIAARKDDTKSAALLLQN 214

Query: 862  -------GQMDVNCQDDGGWTPMIWATEYKHVDLVKLLLSKGSDINIRDNEENICLHWAA 914
                    +M VN   + G+TP+  A  Y +V++  LLL++G+ ++         LH A+
Sbjct: 215  DHNADVQSKMMVNRTTESGFTPLHIAAHYGNVNVATLLLNRGAAVDFTARNGITPLHVAS 274

Query: 915  FSGCVDIAEILLAAKCDLHAVNIHGDSPLHIAARENRYDCVVLFLSRDSDVTLKNKEGET 974
              G  ++ ++LL     + A    G +PLH AAR      V L L R + +  + K G +
Sbjct: 275  KRGNTNMVKLLLDRGGQIDAKTRDGLTPLHCAARSGHDQVVELLLERGAPLLARTKNGLS 334

Query: 975  PLQCASLNSQVWSALQMSKALQDSAP 1000
            PL  A+    V     +   LQ  AP
Sbjct: 335  PLHMAAQGDHVECVKHL---LQHKAP 357



 Score =  108 bits (271), Expect = 3e-23
 Identities = 77/239 (32%), Positives = 116/239 (48%), Gaps = 3/239 (1%)

Query: 742 LYFSARQGELQKVLLMLVDGIDPNFKMEHQNKRSPLHAAAEAGHVDICHMLVQAGANIDT 801
           L+ +A  G  +   L+L    +PN +    N  +PLH A +   + +  +LV+ GA+I  
Sbjct: 369 LHVAAHCGHYRVTKLLLDKRANPNARA--LNGFTPLHIACKKNRIKVMELLVKYGASIQA 426

Query: 802 CSEDQRTPLMEAAENNHLEAVKYLIKAGALVDPKDAEGSTCLHLAAKKGHYEVVQYLLSN 861
            +E   TP+  AA   HL  V  L++ GA  D  +  G T LH+AA+ G  EVV+ LL N
Sbjct: 427 ITESGLTPIHVAAFMGHLNIVLLLLQNGASPDVTNIRGETALHMAARAGQVEVVRCLLRN 486

Query: 862 GQMDVNCQDDGGWTPMIWATEYKHVDLVKLLLSKGSDINIRDNEENICLHWAAFSGCVDI 921
           G + V+ +     TP+  A+     ++V+LLL   +  +         LH +A  G VD+
Sbjct: 487 GAL-VDARAREEQTPLHIASRLGKTEIVQLLLQHMAHPDAATTNGYTPLHISAREGQVDV 545

Query: 922 AEILLAAKCDLHAVNIHGDSPLHIAARENRYDCVVLFLSRDSDVTLKNKEGETPLQCAS 980
           A +LL A          G +PLH+AA+    D   L L R +      K G TPL  A+
Sbjct: 546 ASVLLEAGAAHSLATKKGFTPLHVAAKYGSLDVAKLLLQRRAAADSAGKNGLTPLHVAA 604



 Score =  108 bits (269), Expect = 4e-23
 Identities = 75/239 (31%), Positives = 120/239 (50%), Gaps = 3/239 (1%)

Query: 742 LYFSARQGELQKVLLMLVDGIDPNFKMEHQNKRSPLHAAAEAGHVDICHMLVQAGANIDT 801
           L+ SAR+G++    ++L  G   +  +  +   +PLH AA+ G +D+  +L+Q  A  D+
Sbjct: 534 LHISAREGQVDVASVLLEAGAAHS--LATKKGFTPLHVAAKYGSLDVAKLLLQRRAAADS 591

Query: 802 CSEDQRTPLMEAAENNHLEAVKYLIKAGALVDPKDAEGSTCLHLAAKKGHYEVVQYLLSN 861
             ++  TPL  AA  ++ +    L++ GA        G T LH+AAKK   ++   LL+ 
Sbjct: 592 AGKNGLTPLHVAAHYDNQKVALLLLEKGASPHATAKNGYTPLHIAAKKNQMQIASTLLNY 651

Query: 862 GQMDVNCQDDGGWTPMIWATEYKHVDLVKLLLSKGSDINIRDNEENICLHWAAFSGCVDI 921
           G  + N     G TP+  A++  H D+V LLL KG++I++        LH AA    V++
Sbjct: 652 GA-ETNIVTKQGVTPLHLASQEGHTDMVTLLLDKGANIHMSTKSGLTSLHLAAQEDKVNV 710

Query: 922 AEILLAAKCDLHAVNIHGDSPLHIAARENRYDCVVLFLSRDSDVTLKNKEGETPLQCAS 980
           A+IL     D  A    G +PL +A        V   L + ++V  K K G TPL  A+
Sbjct: 711 ADILTKHGADQDAHTKLGYTPLIVACHYGNVKMVNFLLKQGANVNAKTKNGYTPLHQAA 769



 Score =  103 bits (257), Expect = 1e-21
 Identities = 73/246 (29%), Positives = 121/246 (49%), Gaps = 7/246 (2%)

Query: 742 LYFSARQGELQKVLLMLVDG--IDPNFKMEHQNKRSPLHAAAEAGHVDICHMLVQAGANI 799
           L+ +AR G+++ V  +L +G  +D   + E    ++PLH A+  G  +I  +L+Q  A+ 
Sbjct: 468 LHMAARAGQVEVVRCLLRNGALVDARAREE----QTPLHIASRLGKTEIVQLLLQHMAHP 523

Query: 800 DTCSEDQRTPLMEAAENNHLEAVKYLIKAGALVDPKDAEGSTCLHLAAKKGHYEVVQYLL 859
           D  + +  TPL  +A    ++    L++AGA       +G T LH+AAK G  +V + LL
Sbjct: 524 DAATTNGYTPLHISAREGQVDVASVLLEAGAAHSLATKKGFTPLHVAAKYGSLDVAKLLL 583

Query: 860 SNGQMDVNCQDDGGWTPMIWATEYKHVDLVKLLLSKGSDINIRDNEENICLHWAAFSGCV 919
              +   +     G TP+  A  Y +  +  LLL KG+  +         LH AA    +
Sbjct: 584 QR-RAAADSAGKNGLTPLHVAAHYDNQKVALLLLEKGASPHATAKNGYTPLHIAAKKNQM 642

Query: 920 DIAEILLAAKCDLHAVNIHGDSPLHIAARENRYDCVVLFLSRDSDVTLKNKEGETPLQCA 979
            IA  LL    + + V   G +PLH+A++E   D V L L + +++ +  K G T L  A
Sbjct: 643 QIASTLLNYGAETNIVTKQGVTPLHLASQEGHTDMVTLLLDKGANIHMSTKSGLTSLHLA 702

Query: 980 SLNSQV 985
           +   +V
Sbjct: 703 AQEDKV 708



 Score =  100 bits (248), Expect = 1e-20
 Identities = 79/270 (29%), Positives = 120/270 (44%), Gaps = 3/270 (1%)

Query: 716 GKETLESALIALDSEKPKKLRFHPKQLYFSARQGELQKVLLMLVDGIDPNFKMEHQNKRS 775
           G   +   L+    +   K R     L+ +AR G  Q V L+L  G         +N  S
Sbjct: 277 GNTNMVKLLLDRGGQIDAKTRDGLTPLHCAARSGHDQVVELLLERGAP--LLARTKNGLS 334

Query: 776 PLHAAAEAGHVDICHMLVQAGANIDTCSEDQRTPLMEAAENNHLEAVKYLIKAGALVDPK 835
           PLH AA+  HV+    L+Q  A +D  + D  T L  AA   H    K L+   A  + +
Sbjct: 335 PLHMAAQGDHVECVKHLLQHKAPVDDVTLDYLTALHVAAHCGHYRVTKLLLDKRANPNAR 394

Query: 836 DAEGSTCLHLAAKKGHYEVVQYLLSNGQMDVNCQDDGGWTPMIWATEYKHVDLVKLLLSK 895
              G T LH+A KK   +V++ L+  G   +    + G TP+  A    H+++V LLL  
Sbjct: 395 ALNGFTPLHIACKKNRIKVMELLVKYGA-SIQAITESGLTPIHVAAFMGHLNIVLLLLQN 453

Query: 896 GSDINIRDNEENICLHWAAFSGCVDIAEILLAAKCDLHAVNIHGDSPLHIAARENRYDCV 955
           G+  ++ +      LH AA +G V++   LL     + A      +PLHIA+R  + + V
Sbjct: 454 GASPDVTNIRGETALHMAARAGQVEVVRCLLRNGALVDARAREEQTPLHIASRLGKTEIV 513

Query: 956 VLFLSRDSDVTLKNKEGETPLQCASLNSQV 985
            L L   +        G TPL  ++   QV
Sbjct: 514 QLLLQHMAHPDAATTNGYTPLHISAREGQV 543



 Score = 92.0 bits (227), Expect = 3e-18
 Identities = 63/207 (30%), Positives = 99/207 (47%), Gaps = 3/207 (1%)

Query: 742 LYFSARQGELQKVLLMLVDGIDPNFKMEHQNKRSPLHAAAEAGHVDICHMLVQAGANIDT 801
           L+ +A     +  LL+L  G  P+   +  N  +PLH AA+   + I   L+  GA  + 
Sbjct: 600 LHVAAHYDNQKVALLLLEKGASPHATAK--NGYTPLHIAAKKNQMQIASTLLNYGAETNI 657

Query: 802 CSEDQRTPLMEAAENNHLEAVKYLIKAGALVDPKDAEGSTCLHLAAKKGHYEVVQYLLSN 861
            ++   TPL  A++  H + V  L+  GA +      G T LHLAA++    V   L  +
Sbjct: 658 VTKQGVTPLHLASQEGHTDMVTLLLDKGANIHMSTKSGLTSLHLAAQEDKVNVADILTKH 717

Query: 862 GQMDVNCQDDGGWTPMIWATEYKHVDLVKLLLSKGSDINIRDNEENICLHWAAFSGCVDI 921
           G  D +     G+TP+I A  Y +V +V  LL +G+++N +       LH AA  G   I
Sbjct: 718 GA-DQDAHTKLGYTPLIVACHYGNVKMVNFLLKQGANVNAKTKNGYTPLHQAAQQGHTHI 776

Query: 922 AEILLAAKCDLHAVNIHGDSPLHIAAR 948
             +LL      +A   +G++ L IA R
Sbjct: 777 INVLLQHGAKPNATTANGNTALAIAKR 803



 Score = 77.0 bits (188), Expect = 1e-13
 Identities = 52/184 (28%), Positives = 89/184 (48%), Gaps = 3/184 (1%)

Query: 742 LYFSARQGELQKVLLMLVDGIDPNFKMEHQNKRSPLHAAAEAGHVDICHMLVQAGANIDT 801
           L+ +A++ ++Q    +L  G + N   +     +PLH A++ GH D+  +L+  GANI  
Sbjct: 633 LHIAAKKNQMQIASTLLNYGAETNIVTKQGV--TPLHLASQEGHTDMVTLLLDKGANIHM 690

Query: 802 CSEDQRTPLMEAAENNHLEAVKYLIKAGALVDPKDAEGSTCLHLAAKKGHYEVVQYLLSN 861
            ++   T L  AA+ + +     L K GA  D     G T L +A   G+ ++V +LL  
Sbjct: 691 STKSGLTSLHLAAQEDKVNVADILTKHGADQDAHTKLGYTPLIVACHYGNVKMVNFLLKQ 750

Query: 862 GQMDVNCQDDGGWTPMIWATEYKHVDLVKLLLSKGSDINIRDNEENICLHWAAFSGCVDI 921
           G  +VN +   G+TP+  A +  H  ++ +LL  G+  N      N  L  A   G + +
Sbjct: 751 GA-NVNAKTKNGYTPLHQAAQQGHTHIINVLLQHGAKPNATTANGNTALAIAKRLGYISV 809

Query: 922 AEIL 925
            + L
Sbjct: 810 VDTL 813



 Score = 42.0 bits (97), Expect = 0.004
 Identities = 26/101 (25%), Positives = 49/101 (48%)

Query: 885 HVDLVKLLLSKGSDINIRDNEENICLHWAAFSGCVDIAEILLAAKCDLHAVNIHGDSPLH 944
           ++D V   L  G DIN  +      LH AA  G V + + LL     + +    G++ LH
Sbjct: 43  NLDKVVEYLKGGIDINTCNQNGLNALHLAAKEGHVGLVQELLGRGSSVDSATKKGNTALH 102

Query: 945 IAARENRYDCVVLFLSRDSDVTLKNKEGETPLQCASLNSQV 985
           IA+   + + V + +   +++  +++ G TPL  A+  + +
Sbjct: 103 IASLAGQAEVVKVLVKEGANINAQSQNGFTPLYMAAQENHI 143



 Score = 40.8 bits (94), Expect = 0.009
 Identities = 27/83 (32%), Positives = 39/83 (46%)

Query: 902 RDNEENICLHWAAFSGCVDIAEILLAAKCDLHAVNIHGDSPLHIAARENRYDCVVLFLSR 961
           + ++ N     AA +G +D     L    D++  N +G + LH+AA+E     V   L R
Sbjct: 27  KKSDSNASFLRAARAGNLDKVVEYLKGGIDINTCNQNGLNALHLAAKEGHVGLVQELLGR 86

Query: 962 DSDVTLKNKEGETPLQCASLNSQ 984
            S V    K+G T L  ASL  Q
Sbjct: 87  GSSVDSATKKGNTALHIASLAGQ 109


>gi|188595682 ankyrin 2 isoform 3 [Homo sapiens]
          Length = 1863

 Score =  115 bits (287), Expect = 4e-25
 Identities = 83/273 (30%), Positives = 129/273 (47%), Gaps = 40/273 (14%)

Query: 745 SARQGELQKVLLMLVDGIDPNFKMEHQNKRSPLHAAAEAGHVDICHMLVQAGANIDTCSE 804
           +AR G L KV+  L  GID N    +QN  + LH AA+ GHV +   L+  G+++D+ ++
Sbjct: 17  AARAGNLDKVVEYLKGGIDINTC--NQNGLNALHLAAKEGHVGLVQELLGRGSSVDSATK 74

Query: 805 DQRTPLMEAAENNHLEAVKYLIKAGALVDPKDAEGSTCLHLAAKKGHYEVVQYLLSNGQM 864
              T L  A+     E VK L+K GA ++ +   G T L++AA++ H +VV+YLL NG  
Sbjct: 75  KGNTALHIASLAGQAEVVKVLVKEGANINAQSQNGFTPLYMAAQENHIDVVKYLLENGAN 134

Query: 865 DVNCQDDGGWTPMIWATEYKHVDLVKLLLSKGSDINIR--------------------DN 904
                +D G+TP+  A +  H   V +LL   +   +R                     N
Sbjct: 135 QSTATED-GFTPLAVALQQGHNQAVAILLENDTKGKVRLPALHIAARKDDTKSAALLLQN 193

Query: 905 EEN-----------------ICLHWAAFSGCVDIAEILLAAKCDLHAVNIHGDSPLHIAA 947
           + N                   LH AA  G V++A +LL     +     +G +PLH+A+
Sbjct: 194 DHNADVQSKMMVNRTTESGFTPLHIAAHYGNVNVATLLLNRGAAVDFTARNGITPLHVAS 253

Query: 948 RENRYDCVVLFLSRDSDVTLKNKEGETPLQCAS 980
           +    + V L L R   +  K ++G TPL CA+
Sbjct: 254 KRGNTNMVKLLLDRGGQIDAKTRDGLTPLHCAA 286



 Score =  111 bits (278), Expect = 4e-24
 Identities = 74/266 (27%), Positives = 137/266 (51%), Gaps = 9/266 (3%)

Query: 721 ESALIALDSEKPKKLRFHPKQLYFSARQGELQKVLLMLVDGIDPNFKMEHQNKRS----- 775
           ++  I L+++   K+R     L+ +AR+ + +   L+L +  + + + +    R+     
Sbjct: 156 QAVAILLENDTKGKVRL--PALHIAARKDDTKSAALLLQNDHNADVQSKMMVNRTTESGF 213

Query: 776 -PLHAAAEAGHVDICHMLVQAGANIDTCSEDQRTPLMEAAENNHLEAVKYLIKAGALVDP 834
            PLH AA  G+V++  +L+  GA +D  + +  TPL  A++  +   VK L+  G  +D 
Sbjct: 214 TPLHIAAHYGNVNVATLLLNRGAAVDFTARNGITPLHVASKRGNTNMVKLLLDRGGQIDA 273

Query: 835 KDAEGSTCLHLAAKKGHYEVVQYLLSNGQMDVNCQDDGGWTPMIWATEYKHVDLVKLLLS 894
           K  +G T LH AA+ GH +VV+ LL  G   +  +   G +P+  A +  HV+ VK LL 
Sbjct: 274 KTRDGLTPLHCAARSGHDQVVELLLERG-APLLARTKNGLSPLHMAAQGDHVECVKHLLQ 332

Query: 895 KGSDINIRDNEENICLHWAAFSGCVDIAEILLAAKCDLHAVNIHGDSPLHIAARENRYDC 954
             + ++    +    LH AA  G   + ++LL  + + +A  ++G +PLHIA ++NR   
Sbjct: 333 HKAPVDDVTLDYLTALHVAAHCGHYRVTKLLLDKRANPNARALNGFTPLHIACKKNRIKV 392

Query: 955 VVLFLSRDSDVTLKNKEGETPLQCAS 980
           + L +   + +    + G TP+  A+
Sbjct: 393 MELLVKYGASIQAITESGLTPIHVAA 418



 Score =  109 bits (272), Expect = 2e-23
 Identities = 79/266 (29%), Positives = 129/266 (48%), Gaps = 16/266 (6%)

Query: 742  LYFSARQGELQKVLLMLVDGIDPNFKMEHQNKRSPLHAAAEAGHVDICHMLVQAGANIDT 801
            L+ ++  G+ + V +++ +G   N   + QN  +PL+ AA+  H+D+   L++ GAN  T
Sbjct: 80   LHIASLAGQAEVVKVLVKEGA--NINAQSQNGFTPLYMAAQENHIDVVKYLLENGANQST 137

Query: 802  CSEDQRTPLMEAAENNHLEAVKYLIKAGALVDPKDAEGSTCLHLAAKKGHYEVVQYLLSN 861
             +ED  TPL  A +  H +AV  L++     D K       LH+AA+K   +    LL N
Sbjct: 138  ATEDGFTPLAVALQQGHNQAVAILLEN----DTKGKVRLPALHIAARKDDTKSAALLLQN 193

Query: 862  -------GQMDVNCQDDGGWTPMIWATEYKHVDLVKLLLSKGSDINIRDNEENICLHWAA 914
                    +M VN   + G+TP+  A  Y +V++  LLL++G+ ++         LH A+
Sbjct: 194  DHNADVQSKMMVNRTTESGFTPLHIAAHYGNVNVATLLLNRGAAVDFTARNGITPLHVAS 253

Query: 915  FSGCVDIAEILLAAKCDLHAVNIHGDSPLHIAARENRYDCVVLFLSRDSDVTLKNKEGET 974
              G  ++ ++LL     + A    G +PLH AAR      V L L R + +  + K G +
Sbjct: 254  KRGNTNMVKLLLDRGGQIDAKTRDGLTPLHCAARSGHDQVVELLLERGAPLLARTKNGLS 313

Query: 975  PLQCASLNSQVWSALQMSKALQDSAP 1000
            PL  A+    V     +   LQ  AP
Sbjct: 314  PLHMAAQGDHVECVKHL---LQHKAP 336



 Score =  108 bits (271), Expect = 3e-23
 Identities = 77/239 (32%), Positives = 116/239 (48%), Gaps = 3/239 (1%)

Query: 742 LYFSARQGELQKVLLMLVDGIDPNFKMEHQNKRSPLHAAAEAGHVDICHMLVQAGANIDT 801
           L+ +A  G  +   L+L    +PN +    N  +PLH A +   + +  +LV+ GA+I  
Sbjct: 348 LHVAAHCGHYRVTKLLLDKRANPNARA--LNGFTPLHIACKKNRIKVMELLVKYGASIQA 405

Query: 802 CSEDQRTPLMEAAENNHLEAVKYLIKAGALVDPKDAEGSTCLHLAAKKGHYEVVQYLLSN 861
            +E   TP+  AA   HL  V  L++ GA  D  +  G T LH+AA+ G  EVV+ LL N
Sbjct: 406 ITESGLTPIHVAAFMGHLNIVLLLLQNGASPDVTNIRGETALHMAARAGQVEVVRCLLRN 465

Query: 862 GQMDVNCQDDGGWTPMIWATEYKHVDLVKLLLSKGSDINIRDNEENICLHWAAFSGCVDI 921
           G + V+ +     TP+  A+     ++V+LLL   +  +         LH +A  G VD+
Sbjct: 466 GAL-VDARAREEQTPLHIASRLGKTEIVQLLLQHMAHPDAATTNGYTPLHISAREGQVDV 524

Query: 922 AEILLAAKCDLHAVNIHGDSPLHIAARENRYDCVVLFLSRDSDVTLKNKEGETPLQCAS 980
           A +LL A          G +PLH+AA+    D   L L R +      K G TPL  A+
Sbjct: 525 ASVLLEAGAAHSLATKKGFTPLHVAAKYGSLDVAKLLLQRRAAADSAGKNGLTPLHVAA 583



 Score =  108 bits (269), Expect = 4e-23
 Identities = 75/239 (31%), Positives = 120/239 (50%), Gaps = 3/239 (1%)

Query: 742 LYFSARQGELQKVLLMLVDGIDPNFKMEHQNKRSPLHAAAEAGHVDICHMLVQAGANIDT 801
           L+ SAR+G++    ++L  G   +  +  +   +PLH AA+ G +D+  +L+Q  A  D+
Sbjct: 513 LHISAREGQVDVASVLLEAGAAHS--LATKKGFTPLHVAAKYGSLDVAKLLLQRRAAADS 570

Query: 802 CSEDQRTPLMEAAENNHLEAVKYLIKAGALVDPKDAEGSTCLHLAAKKGHYEVVQYLLSN 861
             ++  TPL  AA  ++ +    L++ GA        G T LH+AAKK   ++   LL+ 
Sbjct: 571 AGKNGLTPLHVAAHYDNQKVALLLLEKGASPHATAKNGYTPLHIAAKKNQMQIASTLLNY 630

Query: 862 GQMDVNCQDDGGWTPMIWATEYKHVDLVKLLLSKGSDINIRDNEENICLHWAAFSGCVDI 921
           G  + N     G TP+  A++  H D+V LLL KG++I++        LH AA    V++
Sbjct: 631 GA-ETNIVTKQGVTPLHLASQEGHTDMVTLLLDKGANIHMSTKSGLTSLHLAAQEDKVNV 689

Query: 922 AEILLAAKCDLHAVNIHGDSPLHIAARENRYDCVVLFLSRDSDVTLKNKEGETPLQCAS 980
           A+IL     D  A    G +PL +A        V   L + ++V  K K G TPL  A+
Sbjct: 690 ADILTKHGADQDAHTKLGYTPLIVACHYGNVKMVNFLLKQGANVNAKTKNGYTPLHQAA 748



 Score =  103 bits (257), Expect = 1e-21
 Identities = 73/246 (29%), Positives = 121/246 (49%), Gaps = 7/246 (2%)

Query: 742 LYFSARQGELQKVLLMLVDG--IDPNFKMEHQNKRSPLHAAAEAGHVDICHMLVQAGANI 799
           L+ +AR G+++ V  +L +G  +D   + E    ++PLH A+  G  +I  +L+Q  A+ 
Sbjct: 447 LHMAARAGQVEVVRCLLRNGALVDARAREE----QTPLHIASRLGKTEIVQLLLQHMAHP 502

Query: 800 DTCSEDQRTPLMEAAENNHLEAVKYLIKAGALVDPKDAEGSTCLHLAAKKGHYEVVQYLL 859
           D  + +  TPL  +A    ++    L++AGA       +G T LH+AAK G  +V + LL
Sbjct: 503 DAATTNGYTPLHISAREGQVDVASVLLEAGAAHSLATKKGFTPLHVAAKYGSLDVAKLLL 562

Query: 860 SNGQMDVNCQDDGGWTPMIWATEYKHVDLVKLLLSKGSDINIRDNEENICLHWAAFSGCV 919
              +   +     G TP+  A  Y +  +  LLL KG+  +         LH AA    +
Sbjct: 563 QR-RAAADSAGKNGLTPLHVAAHYDNQKVALLLLEKGASPHATAKNGYTPLHIAAKKNQM 621

Query: 920 DIAEILLAAKCDLHAVNIHGDSPLHIAARENRYDCVVLFLSRDSDVTLKNKEGETPLQCA 979
            IA  LL    + + V   G +PLH+A++E   D V L L + +++ +  K G T L  A
Sbjct: 622 QIASTLLNYGAETNIVTKQGVTPLHLASQEGHTDMVTLLLDKGANIHMSTKSGLTSLHLA 681

Query: 980 SLNSQV 985
           +   +V
Sbjct: 682 AQEDKV 687



 Score =  100 bits (248), Expect = 1e-20
 Identities = 79/270 (29%), Positives = 120/270 (44%), Gaps = 3/270 (1%)

Query: 716 GKETLESALIALDSEKPKKLRFHPKQLYFSARQGELQKVLLMLVDGIDPNFKMEHQNKRS 775
           G   +   L+    +   K R     L+ +AR G  Q V L+L  G         +N  S
Sbjct: 256 GNTNMVKLLLDRGGQIDAKTRDGLTPLHCAARSGHDQVVELLLERGAP--LLARTKNGLS 313

Query: 776 PLHAAAEAGHVDICHMLVQAGANIDTCSEDQRTPLMEAAENNHLEAVKYLIKAGALVDPK 835
           PLH AA+  HV+    L+Q  A +D  + D  T L  AA   H    K L+   A  + +
Sbjct: 314 PLHMAAQGDHVECVKHLLQHKAPVDDVTLDYLTALHVAAHCGHYRVTKLLLDKRANPNAR 373

Query: 836 DAEGSTCLHLAAKKGHYEVVQYLLSNGQMDVNCQDDGGWTPMIWATEYKHVDLVKLLLSK 895
              G T LH+A KK   +V++ L+  G   +    + G TP+  A    H+++V LLL  
Sbjct: 374 ALNGFTPLHIACKKNRIKVMELLVKYGA-SIQAITESGLTPIHVAAFMGHLNIVLLLLQN 432

Query: 896 GSDINIRDNEENICLHWAAFSGCVDIAEILLAAKCDLHAVNIHGDSPLHIAARENRYDCV 955
           G+  ++ +      LH AA +G V++   LL     + A      +PLHIA+R  + + V
Sbjct: 433 GASPDVTNIRGETALHMAARAGQVEVVRCLLRNGALVDARAREEQTPLHIASRLGKTEIV 492

Query: 956 VLFLSRDSDVTLKNKEGETPLQCASLNSQV 985
            L L   +        G TPL  ++   QV
Sbjct: 493 QLLLQHMAHPDAATTNGYTPLHISAREGQV 522



 Score = 92.0 bits (227), Expect = 3e-18
 Identities = 63/207 (30%), Positives = 99/207 (47%), Gaps = 3/207 (1%)

Query: 742 LYFSARQGELQKVLLMLVDGIDPNFKMEHQNKRSPLHAAAEAGHVDICHMLVQAGANIDT 801
           L+ +A     +  LL+L  G  P+   +  N  +PLH AA+   + I   L+  GA  + 
Sbjct: 579 LHVAAHYDNQKVALLLLEKGASPHATAK--NGYTPLHIAAKKNQMQIASTLLNYGAETNI 636

Query: 802 CSEDQRTPLMEAAENNHLEAVKYLIKAGALVDPKDAEGSTCLHLAAKKGHYEVVQYLLSN 861
            ++   TPL  A++  H + V  L+  GA +      G T LHLAA++    V   L  +
Sbjct: 637 VTKQGVTPLHLASQEGHTDMVTLLLDKGANIHMSTKSGLTSLHLAAQEDKVNVADILTKH 696

Query: 862 GQMDVNCQDDGGWTPMIWATEYKHVDLVKLLLSKGSDINIRDNEENICLHWAAFSGCVDI 921
           G  D +     G+TP+I A  Y +V +V  LL +G+++N +       LH AA  G   I
Sbjct: 697 GA-DQDAHTKLGYTPLIVACHYGNVKMVNFLLKQGANVNAKTKNGYTPLHQAAQQGHTHI 755

Query: 922 AEILLAAKCDLHAVNIHGDSPLHIAAR 948
             +LL      +A   +G++ L IA R
Sbjct: 756 INVLLQHGAKPNATTANGNTALAIAKR 782



 Score = 77.0 bits (188), Expect = 1e-13
 Identities = 52/184 (28%), Positives = 89/184 (48%), Gaps = 3/184 (1%)

Query: 742 LYFSARQGELQKVLLMLVDGIDPNFKMEHQNKRSPLHAAAEAGHVDICHMLVQAGANIDT 801
           L+ +A++ ++Q    +L  G + N   +     +PLH A++ GH D+  +L+  GANI  
Sbjct: 612 LHIAAKKNQMQIASTLLNYGAETNIVTKQGV--TPLHLASQEGHTDMVTLLLDKGANIHM 669

Query: 802 CSEDQRTPLMEAAENNHLEAVKYLIKAGALVDPKDAEGSTCLHLAAKKGHYEVVQYLLSN 861
            ++   T L  AA+ + +     L K GA  D     G T L +A   G+ ++V +LL  
Sbjct: 670 STKSGLTSLHLAAQEDKVNVADILTKHGADQDAHTKLGYTPLIVACHYGNVKMVNFLLKQ 729

Query: 862 GQMDVNCQDDGGWTPMIWATEYKHVDLVKLLLSKGSDINIRDNEENICLHWAAFSGCVDI 921
           G  +VN +   G+TP+  A +  H  ++ +LL  G+  N      N  L  A   G + +
Sbjct: 730 GA-NVNAKTKNGYTPLHQAAQQGHTHIINVLLQHGAKPNATTANGNTALAIAKRLGYISV 788

Query: 922 AEIL 925
            + L
Sbjct: 789 VDTL 792



 Score = 66.6 bits (161), Expect = 1e-10
 Identities = 44/159 (27%), Positives = 75/159 (47%), Gaps = 1/159 (0%)

Query: 805 DQRTPLMEAAENNHLEAVKYLIKAGALVDPKDAEGSTCLHLAAKKGHYEVVQYLLSNGQM 864
           D     + AA   +L+ V   +K G  ++  +  G   LHLAAK+GH  +VQ LL  G  
Sbjct: 9   DSNASFLRAARAGNLDKVVEYLKGGIDINTCNQNGLNALHLAAKEGHVGLVQELLGRGS- 67

Query: 865 DVNCQDDGGWTPMIWATEYKHVDLVKLLLSKGSDINIRDNEENICLHWAAFSGCVDIAEI 924
            V+     G T +  A+     ++VK+L+ +G++IN +       L+ AA    +D+ + 
Sbjct: 68  SVDSATKKGNTALHIASLAGQAEVVKVLVKEGANINAQSQNGFTPLYMAAQENHIDVVKY 127

Query: 925 LLAAKCDLHAVNIHGDSPLHIAARENRYDCVVLFLSRDS 963
           LL    +       G +PL +A ++     V + L  D+
Sbjct: 128 LLENGANQSTATEDGFTPLAVALQQGHNQAVAILLENDT 166



 Score = 42.0 bits (97), Expect = 0.004
 Identities = 26/101 (25%), Positives = 49/101 (48%)

Query: 885 HVDLVKLLLSKGSDINIRDNEENICLHWAAFSGCVDIAEILLAAKCDLHAVNIHGDSPLH 944
           ++D V   L  G DIN  +      LH AA  G V + + LL     + +    G++ LH
Sbjct: 22  NLDKVVEYLKGGIDINTCNQNGLNALHLAAKEGHVGLVQELLGRGSSVDSATKKGNTALH 81

Query: 945 IAARENRYDCVVLFLSRDSDVTLKNKEGETPLQCASLNSQV 985
           IA+   + + V + +   +++  +++ G TPL  A+  + +
Sbjct: 82  IASLAGQAEVVKVLVKEGANINAQSQNGFTPLYMAAQENHI 122



 Score = 41.2 bits (95), Expect = 0.007
 Identities = 27/84 (32%), Positives = 40/84 (47%)

Query: 901 IRDNEENICLHWAAFSGCVDIAEILLAAKCDLHAVNIHGDSPLHIAARENRYDCVVLFLS 960
           ++ ++ N     AA +G +D     L    D++  N +G + LH+AA+E     V   L 
Sbjct: 5   LQKSDSNASFLRAARAGNLDKVVEYLKGGIDINTCNQNGLNALHLAAKEGHVGLVQELLG 64

Query: 961 RDSDVTLKNKEGETPLQCASLNSQ 984
           R S V    K+G T L  ASL  Q
Sbjct: 65  RGSSVDSATKKGNTALHIASLAGQ 88


>gi|30425444 ankyrin repeat and kinase domain containing 1 [Homo
           sapiens]
          Length = 765

 Score =  114 bits (285), Expect = 6e-25
 Identities = 75/237 (31%), Positives = 115/237 (48%), Gaps = 4/237 (1%)

Query: 746 ARQGELQKVLLMLVDG-IDPNFKMEHQNKRSPLHAAAEAGHVDICHMLVQAGANIDTCSE 804
           A Q   + V  +LV    DPN  +     ++PLH AA  GHV +  +L   GA +D    
Sbjct: 468 AAQNNFENVARLLVSRQADPN--LHEAEGKTPLHVAAYFGHVSLVKLLTSQGAELDAQQR 525

Query: 805 DQRTPLMEAAENNHLEAVKYLIKAGALVDPKDAEGSTCLHLAAKKGHYEVVQYLLSNGQM 864
           + RTPL  A E   + A+++L+K+GA+ D  D  G   LH AA +G Y + + LL  G  
Sbjct: 526 NLRTPLHLAVERGKVRAIQHLLKSGAVPDALDQSGYGPLHTAAARGKYLICKMLLRYG-A 584

Query: 865 DVNCQDDGGWTPMIWATEYKHVDLVKLLLSKGSDINIRDNEENICLHWAAFSGCVDIAEI 924
            +      GWTP+  A    H++++ LL    +++          LH AA  G   +   
Sbjct: 585 SLELPTHQGWTPLHLAAYKGHLEIIHLLAESHANMGALGAVNWTPLHLAARHGEEAVVSA 644

Query: 925 LLAAKCDLHAVNIHGDSPLHIAARENRYDCVVLFLSRDSDVTLKNKEGETPLQCASL 981
           LL    D +A    G +PLH+A + + +  V+  L   ++V  +NK G TP   A+L
Sbjct: 645 LLQCGADPNAAEQSGWTPLHLAVQRSTFLSVINLLEHHANVHARNKVGWTPAHLAAL 701



 Score =  113 bits (282), Expect = 1e-24
 Identities = 79/239 (33%), Positives = 123/239 (51%), Gaps = 3/239 (1%)

Query: 742 LYFSARQGELQKVLLMLVDGIDPNFKMEHQNKRSPLHAAAEAGHVDICHMLVQAGANIDT 801
           L+F   QG +++V L+L   +D +   +  +  +PL  AA+    D+C +L+  GA+ + 
Sbjct: 366 LHFLVAQGSVEQVRLLLAHEVDVD--CQTASGYTPLLIAAQDQQPDLCALLLAHGADANR 423

Query: 802 CSEDQRTPLMEAAENNHLEAVKYLIKAGALVDPKDAEGSTCLHLAAKKGHYEVVQYLLSN 861
             ED   PL  AA+N      + L+  GA VD ++ EG T LHLAA + ++E V  LL +
Sbjct: 424 VDEDGWAPLHFAAQNGDDGTARLLLDHGACVDAQEREGWTPLHLAA-QNNFENVARLLVS 482

Query: 862 GQMDVNCQDDGGWTPMIWATEYKHVDLVKLLLSKGSDINIRDNEENICLHWAAFSGCVDI 921
            Q D N  +  G TP+  A  + HV LVKLL S+G++++ +       LH A   G V  
Sbjct: 483 RQADPNLHEAEGKTPLHVAAYFGHVSLVKLLTSQGAELDAQQRNLRTPLHLAVERGKVRA 542

Query: 922 AEILLAAKCDLHAVNIHGDSPLHIAARENRYDCVVLFLSRDSDVTLKNKEGETPLQCAS 980
            + LL +     A++  G  PLH AA   +Y    + L   + + L   +G TPL  A+
Sbjct: 543 IQHLLKSGAVPDALDQSGYGPLHTAAARGKYLICKMLLRYGASLELPTHQGWTPLHLAA 601



 Score = 97.1 bits (240), Expect = 1e-19
 Identities = 69/250 (27%), Positives = 119/250 (47%), Gaps = 3/250 (1%)

Query: 742 LYFSARQGELQKVLLMLVDGIDPNFKMEHQNKRSPLHAAAEAGHVDICHMLVQAGANIDT 801
           L+F+A+ G+     L+L  G   +   + +   +PLH AA+    ++  +LV   A+ + 
Sbjct: 432 LHFAAQNGDDGTARLLLDHGACVD--AQEREGWTPLHLAAQNNFENVARLLVSRQADPNL 489

Query: 802 CSEDQRTPLMEAAENNHLEAVKYLIKAGALVDPKDAEGSTCLHLAAKKGHYEVVQYLLSN 861
              + +TPL  AA   H+  VK L   GA +D +     T LHLA ++G    +Q+LL +
Sbjct: 490 HEAEGKTPLHVAAYFGHVSLVKLLTSQGAELDAQQRNLRTPLHLAVERGKVRAIQHLLKS 549

Query: 862 GQMDVNCQDDGGWTPMIWATEYKHVDLVKLLLSKGSDINIRDNEENICLHWAAFSGCVDI 921
           G +  +  D  G+ P+  A       + K+LL  G+ + +  ++    LH AA+ G ++I
Sbjct: 550 GAVP-DALDQSGYGPLHTAAARGKYLICKMLLRYGASLELPTHQGWTPLHLAAYKGHLEI 608

Query: 922 AEILLAAKCDLHAVNIHGDSPLHIAARENRYDCVVLFLSRDSDVTLKNKEGETPLQCASL 981
             +L  +  ++ A+     +PLH+AAR      V   L   +D     + G TPL  A  
Sbjct: 609 IHLLAESHANMGALGAVNWTPLHLAARHGEEAVVSALLQCGADPNAAEQSGWTPLHLAVQ 668

Query: 982 NSQVWSALQM 991
            S   S + +
Sbjct: 669 RSTFLSVINL 678



 Score = 89.4 bits (220), Expect = 2e-17
 Identities = 64/184 (34%), Positives = 97/184 (52%), Gaps = 8/184 (4%)

Query: 803 SEDQRTPLMEAAENNHLEAVKYLIKAGALVDPKDAE------GSTCLHLAAKKGHYEVVQ 856
           +ED    LM++   N+L+    L     LV P+D E        T LH    +G  E V+
Sbjct: 321 NEDISQELMDSDSGNYLKRALQLSDRKNLV-PRDEELCIYENKVTPLHFLVAQGSVEQVR 379

Query: 857 YLLSNGQMDVNCQDDGGWTPMIWATEYKHVDLVKLLLSKGSDINIRDNEENICLHWAAFS 916
            LL++ ++DV+CQ   G+TP++ A + +  DL  LLL+ G+D N  D +    LH+AA +
Sbjct: 380 LLLAH-EVDVDCQTASGYTPLLIAAQDQQPDLCALLLAHGADANRVDEDGWAPLHFAAQN 438

Query: 917 GCVDIAEILLAAKCDLHAVNIHGDSPLHIAARENRYDCVVLFLSRDSDVTLKNKEGETPL 976
           G    A +LL     + A    G +PLH+AA+ N  +   L +SR +D  L   EG+TPL
Sbjct: 439 GDDGTARLLLDHGACVDAQEREGWTPLHLAAQNNFENVARLLVSRQADPNLHEAEGKTPL 498

Query: 977 QCAS 980
             A+
Sbjct: 499 HVAA 502



 Score = 85.9 bits (211), Expect = 2e-16
 Identities = 69/236 (29%), Positives = 109/236 (46%), Gaps = 3/236 (1%)

Query: 716 GKETLESALIALDSEKPKKLRFHPKQLYFSARQGELQKVLLMLVDGIDPNFKMEHQNKRS 775
           G  +L   L +  +E   + R     L+ +  +G+++ +  +L  G  P+     Q+   
Sbjct: 505 GHVSLVKLLTSQGAELDAQQRNLRTPLHLAVERGKVRAIQHLLKSGAVPDAL--DQSGYG 562

Query: 776 PLHAAAEAGHVDICHMLVQAGANIDTCSEDQRTPLMEAAENNHLEAVKYLIKAGALVDPK 835
           PLH AA  G   IC ML++ GA+++  +    TPL  AA   HLE +  L ++ A +   
Sbjct: 563 PLHTAAARGKYLICKMLLRYGASLELPTHQGWTPLHLAAYKGHLEIIHLLAESHANMGAL 622

Query: 836 DAEGSTCLHLAAKKGHYEVVQYLLSNGQMDVNCQDDGGWTPMIWATEYKHVDLVKLLLSK 895
            A   T LHLAA+ G   VV  LL  G  D N  +  GWTP+  A +      V  LL  
Sbjct: 623 GAVNWTPLHLAARHGEEAVVSALLQCGA-DPNAAEQSGWTPLHLAVQRSTFLSVINLLEH 681

Query: 896 GSDINIRDNEENICLHWAAFSGCVDIAEILLAAKCDLHAVNIHGDSPLHIAARENR 951
            ++++ R+       H AA  G   I ++L+ A   L   +    +PL +A R  +
Sbjct: 682 HANVHARNKVGWTPAHLAALKGNTAILKVLVEAGAQLDVQDGVSCTPLQLALRSRK 737



 Score = 75.1 bits (183), Expect = 4e-13
 Identities = 52/191 (27%), Positives = 94/191 (49%), Gaps = 1/191 (0%)

Query: 804 EDQRTPLMEAAENNHLEAVKYLIKAGALVDPKDAEGSTCLHLAAKKGHYEVVQYLLSNGQ 863
           E++ TPL        +E V+ L+     VD + A G T L +AA+    ++   LL++G 
Sbjct: 360 ENKVTPLHFLVAQGSVEQVRLLLAHEVDVDCQTASGYTPLLIAAQDQQPDLCALLLAHGA 419

Query: 864 MDVNCQDDGGWTPMIWATEYKHVDLVKLLLSKGSDINIRDNEENICLHWAAFSGCVDIAE 923
            D N  D+ GW P+ +A +       +LLL  G+ ++ ++ E    LH AA +   ++A 
Sbjct: 420 -DANRVDEDGWAPLHFAAQNGDDGTARLLLDHGACVDAQEREGWTPLHLAAQNNFENVAR 478

Query: 924 ILLAAKCDLHAVNIHGDSPLHIAARENRYDCVVLFLSRDSDVTLKNKEGETPLQCASLNS 983
           +L++ + D +     G +PLH+AA       V L  S+ +++  + +   TPL  A    
Sbjct: 479 LLVSRQADPNLHEAEGKTPLHVAAYFGHVSLVKLLTSQGAELDAQQRNLRTPLHLAVERG 538

Query: 984 QVWSALQMSKA 994
           +V +   + K+
Sbjct: 539 KVRAIQHLLKS 549



 Score = 50.8 bits (120), Expect = 8e-06
 Identities = 38/122 (31%), Positives = 61/122 (50%), Gaps = 3/122 (2%)

Query: 775 SPLHAAAEAGHVDICHMLVQAGANIDTCSEDQRTPLMEAAENNHLEAVKYLIKAGALVDP 834
           +PLH AA  G   +   L+Q GA+ +   +   TPL  A + +   +V  L++  A V  
Sbjct: 628 TPLHLAARHGEEAVVSALLQCGADPNAAEQSGWTPLHLAVQRSTFLSVINLLEHHANVHA 687

Query: 835 KDAEGSTCLHLAAKKGHYEVVQYLLSNG-QMDVNCQDDGGWTPMIWATEYKHVDLVKLLL 893
           ++  G T  HLAA KG+  +++ L+  G Q+DV  QD    TP+  A   +   ++  L 
Sbjct: 688 RNKVGWTPAHLAALKGNTAILKVLVEAGAQLDV--QDGVSCTPLQLALRSRKQGIMSFLE 745

Query: 894 SK 895
            K
Sbjct: 746 GK 747


>gi|24233530 ankyrin repeat domain 44 [Homo sapiens]
          Length = 919

 Score =  114 bits (285), Expect = 6e-25
 Identities = 76/215 (35%), Positives = 112/215 (52%), Gaps = 7/215 (3%)

Query: 773 KRSPLHAAAEAGHVDICHMLVQAGANIDTCSEDQRTPLMEAAENNHLEAVKYLIKAGALV 832
           KR+PLH AA  G  +I  +L+ +GA ++       TPL  A  +   EAV+ LIK  A V
Sbjct: 16  KRTPLHVAAFLGDAEIIELLILSGARVNAKDNMWLTPLHRAVASRSEEAVQVLIKHSADV 75

Query: 833 DPKDAEGSTCLHLAAKKGHY---EVVQYLLSNGQMDVNCQDDGGWTPMIWATEYKHVDLV 889
           + +D    T LH+AA        EV+  LLS+    VN  D GG T +  A    HV++V
Sbjct: 76  NARDKNWQTPLHVAAANKAVKCAEVIIPLLSS----VNVSDRGGRTALHHAALNGHVEMV 131

Query: 890 KLLLSKGSDINIRDNEENICLHWAAFSGCVDIAEILLAAKCDLHAVNIHGDSPLHIAARE 949
            LLL+KG++IN  D ++   LHWAA+ G +D+  +L+    ++   +  G +PLH AA  
Sbjct: 132 NLLLAKGANINAFDKKDRRALHWAAYMGHLDVVALLINHGAEVTCKDKKGYTPLHAAASN 191

Query: 950 NRYDCVVLFLSRDSDVTLKNKEGETPLQCASLNSQ 984
            + + V   L+   ++   N  G T L  A  N Q
Sbjct: 192 GQINVVKHLLNLGVEIDEINVYGNTALHIACYNGQ 226



 Score =  110 bits (276), Expect = 7e-24
 Identities = 73/243 (30%), Positives = 121/243 (49%), Gaps = 4/243 (1%)

Query: 742 LYFSARQGELQKVLLMLVDGIDPNFKMEHQNKRSPLHAAAEAGHVDICHMLVQAGANIDT 801
           L+ +A  G ++ V L+L  G   N     +  R  LH AA  GH+D+  +L+  GA +  
Sbjct: 119 LHHAALNGHVEMVNLLLAKGA--NINAFDKKDRRALHWAAYMGHLDVVALLINHGAEVTC 176

Query: 802 CSEDQRTPLMEAAENNHLEAVKYLIKAGALVDPKDAEGSTCLHLAAKKGHYEVVQYLLSN 861
             +   TPL  AA N  +  VK+L+  G  +D  +  G+T LH+A   G   VV  L+  
Sbjct: 177 KDKKGYTPLHAAASNGQINVVKHLLNLGVEIDEINVYGNTALHIACYNGQDAVVNELIDY 236

Query: 862 GQMDVNCQDDGGWTPMIWATEYKHVDL-VKLLLSKGSDINIRDNEENICLHWAAFSGCVD 920
           G  +VN  ++ G+TP+ +A    H  L ++LL++ G+D+NI+  +    LH  A  G   
Sbjct: 237 G-ANVNQPNNNGFTPLHFAAASTHGALCLELLVNNGADVNIQSKDGKSPLHMTAVHGRFT 295

Query: 921 IAEILLAAKCDLHAVNIHGDSPLHIAARENRYDCVVLFLSRDSDVTLKNKEGETPLQCAS 980
            ++ L+    ++  V+  G++PLH+AAR      +    +  +D          PL  A+
Sbjct: 296 RSQTLIQNGGEIDCVDKDGNTPLHVAARYGHELLINTLRTSGADTAKCGIHSMFPLHLAA 355

Query: 981 LNS 983
           LN+
Sbjct: 356 LNA 358



 Score =  106 bits (265), Expect = 1e-22
 Identities = 64/215 (29%), Positives = 117/215 (54%), Gaps = 2/215 (0%)

Query: 771 QNKRSPLHAAAEAGHVDICHMLVQAGANIDTCSEDQRTPLMEAAENNHLEAVKYLIKAGA 830
           +N ++PLH AA    V    +++   ++++      RT L  AA N H+E V  L+  GA
Sbjct: 80  KNWQTPLHVAAANKAVKCAEVIIPLLSSVNVSDRGGRTALHHAALNGHVEMVNLLLAKGA 139

Query: 831 LVDPKDAEGSTCLHLAAKKGHYEVVQYLLSNGQMDVNCQDDGGWTPMIWATEYKHVDLVK 890
            ++  D +    LH AA  GH +VV  L+++G  +V C+D  G+TP+  A     +++VK
Sbjct: 140 NINAFDKKDRRALHWAAYMGHLDVVALLINHG-AEVTCKDKKGYTPLHAAASNGQINVVK 198

Query: 891 LLLSKGSDINIRDNEENICLHWAAFSGCVDIAEILLAAKCDLHAVNIHGDSPLHIAAREN 950
            LL+ G +I+  +   N  LH A ++G   +   L+    +++  N +G +PLH AA   
Sbjct: 199 HLLNLGVEIDEINVYGNTALHIACYNGQDAVVNELIDYGANVNQPNNNGFTPLHFAAAST 258

Query: 951 RYD-CVVLFLSRDSDVTLKNKEGETPLQCASLNSQ 984
               C+ L ++  +DV +++K+G++PL   +++ +
Sbjct: 259 HGALCLELLVNNGADVNIQSKDGKSPLHMTAVHGR 293



 Score =  103 bits (256), Expect = 1e-21
 Identities = 65/195 (33%), Positives = 101/195 (51%), Gaps = 1/195 (0%)

Query: 791 MLVQAGANIDTCSEDQRTPLMEAAENNHLEAVKYLIKAGALVDPKDAEGSTCLHLAAKKG 850
           ML+    +++T   ++RTPL  AA     E ++ LI +GA V+ KD    T LH A    
Sbjct: 1   MLIHKTEDVNTLDSEKRTPLHVAAFLGDAEIIELLILSGARVNAKDNMWLTPLHRAVASR 60

Query: 851 HYEVVQYLLSNGQMDVNCQDDGGWTPMIWATEYKHVDLVKLLLSKGSDINIRDNEENICL 910
             E VQ L+ +   DVN +D    TP+  A   K V   ++++   S +N+ D      L
Sbjct: 61  SEEAVQVLIKHSA-DVNARDKNWQTPLHVAAANKAVKCAEVIIPLLSSVNVSDRGGRTAL 119

Query: 911 HWAAFSGCVDIAEILLAAKCDLHAVNIHGDSPLHIAARENRYDCVVLFLSRDSDVTLKNK 970
           H AA +G V++  +LLA   +++A +      LH AA     D V L ++  ++VT K+K
Sbjct: 120 HHAALNGHVEMVNLLLAKGANINAFDKKDRRALHWAAYMGHLDVVALLINHGAEVTCKDK 179

Query: 971 EGETPLQCASLNSQV 985
           +G TPL  A+ N Q+
Sbjct: 180 KGYTPLHAAASNGQI 194



 Score =  100 bits (249), Expect = 9e-21
 Identities = 79/262 (30%), Positives = 112/262 (42%), Gaps = 6/262 (2%)

Query: 740  KQLYFSARQGELQKVLLMLVDGIDPNFKMEHQNKRSPLHAAAEAGHVDICHMLVQAGANI 799
            + L+++A  G L  V L++  G +   K   +   +PLHAAA  G +++   L+  G  I
Sbjct: 150  RALHWAAYMGHLDVVALLINHGAEVTCK--DKKGYTPLHAAASNGQINVVKHLLNLGVEI 207

Query: 800  DTCSEDQRTPLMEAAENNHLEAVKYLIKAGALVDPKDAEGSTCLHLAAKKGHYEVVQYLL 859
            D  +    T L  A  N     V  LI  GA V+  +  G T LH AA   H  +   LL
Sbjct: 208  DEINVYGNTALHIACYNGQDAVVNELIDYGANVNQPNNNGFTPLHFAAASTHGALCLELL 267

Query: 860  SNGQMDVNCQDDGGWTPMIWATEYKHVDLVKLLLSKGSDINIRDNEENICLHWAAFSGCV 919
             N   DVN Q   G +P+     +      + L+  G +I+  D + N  LH AA  G  
Sbjct: 268  VNNGADVNIQSKDGKSPLHMTAVHGRFTRSQTLIQNGGEIDCVDKDGNTPLHVAARYGHE 327

Query: 920  DIAEILLAAKCDLHAVNIHGDSPLHIAARENRYDCVVLFLSRDSDVTLKNKEGETPLQCA 979
             +   L  +  D     IH   PLH+AA     DC    LS   ++   +K G T L  A
Sbjct: 328  LLINTLRTSGADTAKCGIHSMFPLHLAALNAHSDCCRKLLSSGFEIDTPDKFGRTCLHAA 387

Query: 980  SLNSQVWSALQMSKALQDSAPD 1001
            +    V    +  K LQ S  D
Sbjct: 388  AAGGNV----ECIKLLQSSGAD 405



 Score = 94.0 bits (232), Expect = 8e-19
 Identities = 74/248 (29%), Positives = 117/248 (47%), Gaps = 8/248 (3%)

Query: 742 LYFSARQGELQKVLLMLVDGIDPNFKMEHQNK-RSPLHAAAEAGHVDICHMLVQAGANID 800
           ++++A  G  Q  L +L++  +  F+       +SPLH AA  GH     +L+Q+  ++D
Sbjct: 511 IHYAAAYGHRQ-CLELLLERTNSGFEESDSGATKSPLHLAAYNGHHQALEVLLQSLVDLD 569

Query: 801 TCSEDQRTPLMEAAENNHLEAVKYLIKAGALVDPKD-AEGSTCLHLAAKKGHYEVVQYLL 859
              E  RT L  AA   H E V+ LI  GA +  KD     T LH +   GH   ++ LL
Sbjct: 570 IRDEKGRTALDLAAFKGHTECVEALINPGASIFVKDNVTKRTPLHASVINGHTLCLRLLL 629

Query: 860 --SNGQMDVNCQDDGGWTPMIWATEYKHVDLVKLLLSKGSDINIRDNEENICLHWAAFSG 917
             ++    V+ +D  G TP++ A  Y H+D V LLL K ++++  D      LH    +G
Sbjct: 630 EIADNPEAVDVKDAKGQTPLMLAVAYGHIDAVSLLLEKEANVDTVDILGCTALHRGIMTG 689

Query: 918 CVDIAEILLAAKCDLHAVNIHGDSPLHIAARENRYDCVVLFLS---RDSDVTLKNKEGET 974
             +  ++LL  +  +   +  G +PLH AA       +   L     + D   K+ +G T
Sbjct: 690 HEECVQMLLEQEVSILCKDSRGRTPLHYAAARGHATWLSELLQMALSEEDCCFKDNQGYT 749

Query: 975 PLQCASLN 982
           PL  A  N
Sbjct: 750 PLHWACYN 757



 Score = 87.0 bits (214), Expect = 1e-16
 Identities = 69/263 (26%), Positives = 118/263 (44%), Gaps = 37/263 (14%)

Query: 774 RSPLHAAAEAGHVDICHMLVQAGANIDTCSEDQRTPLMEAAENNHLEAVKYLIKAGALVD 833
           ++PL  A   GH+D   +L++  AN+DT      T L       H E V+ L++    + 
Sbjct: 646 QTPLMLAVAYGHIDAVSLLLEKEANVDTVDILGCTALHRGIMTGHEECVQMLLEQEVSIL 705

Query: 834 PKDAEGSTCLHLAAKKGHYEVVQYLLSNGQMDVNC--QDDGGWTPMIWATEYKHVDLVKL 891
            KD+ G T LH AA +GH   +  LL     + +C  +D+ G+TP+ WA    + + +++
Sbjct: 706 CKDSRGRTPLHYAAARGHATWLSELLQMALSEEDCCFKDNQGYTPLHWACYNGNENCIEV 765

Query: 892 LLSK----------------------------------GSDINIRDNEENICLHWAAFSG 917
           LL +                                   S ++ RD++    L  AAF+ 
Sbjct: 766 LLEQKCFRKFIGNPFTPLHCAIINDHGNCASLLLGAIDSSIVSCRDDKGRTPLRAAAFAD 825

Query: 918 CVDIAEILLAAKCDLHAVNIHGDSPLHIAARENRYDCV-VLFLSRDSDVTLKNKEGETPL 976
            V+  ++LL     ++AV+  G + L +AA   +   V +L  S  +D+T+K+K+  TPL
Sbjct: 826 HVECLQLLLRHSAPVNAVDNSGKTALMMAAENGQAGAVDILVNSAQADLTVKDKDLNTPL 885

Query: 977 QCASLNSQVWSALQMSKALQDSA 999
             A        AL +   +QD +
Sbjct: 886 HLACSKGHEKCALLILDKIQDES 908



 Score = 83.2 bits (204), Expect = 1e-15
 Identities = 68/235 (28%), Positives = 104/235 (44%), Gaps = 31/235 (13%)

Query: 776 PLHAAAEAGHVDICHMLVQAGANIDTCSEDQRTPLMEAAENNHLEAVKYLIKAGALVDPK 835
           PLH AA   H D C  L+ +G  IDT  +  RT L  AA   ++E +K L  +GA    K
Sbjct: 350 PLHLAALNAHSDCCRKLLSSGFEIDTPDKFGRTCLHAAAAGGNVECIKLLQSSGADFHKK 409

Query: 836 DAEGSTCLHLAAKKGHYEVVQYLLSNGQMDVNCQDDGGWTPMIWAT-------------- 881
           D  G T LH AA   H+  ++ L++ G  +VN  DD G T + +A               
Sbjct: 410 DKCGRTPLHYAAANCHFHCIETLVTTG-ANVNETDDWGRTALHYAAASDMDRNKTILGNA 468

Query: 882 --------------EYKHVDLVKLLLSKGSDINIRDNEENICLHWAAFSGCVDIAEILLA 927
                         E +    ++ LL   ++ +IRD E    +H+AA  G     E+LL 
Sbjct: 469 HDNSEELERARELKEKEATLCLEFLLQNDANPSIRDKEGYNSIHYAAAYGHRQCLELLLE 528

Query: 928 AKCDLHAVNIHG--DSPLHIAARENRYDCVVLFLSRDSDVTLKNKEGETPLQCAS 980
                   +  G   SPLH+AA    +  + + L    D+ +++++G T L  A+
Sbjct: 529 RTNSGFEESDSGATKSPLHLAAYNGHHQALEVLLQSLVDLDIRDEKGRTALDLAA 583



 Score = 77.0 bits (188), Expect = 1e-13
 Identities = 64/207 (30%), Positives = 101/207 (48%), Gaps = 14/207 (6%)

Query: 774 RSPLHAAAEAGHVD-ICHMLVQAGANIDTCSEDQR--TPLMEAAENNHLEAVKYLIKAGA 830
           R+PLH AA  GH   +  +L  A +  D C +D +  TPL  A  N +   ++ L++   
Sbjct: 712 RTPLHYAAARGHATWLSELLQMALSEEDCCFKDNQGYTPLHWACYNGNENCIEVLLEQKC 771

Query: 831 LVDPKDAEGS--TCLHLAAKKGHYEVVQYLLSNGQMD---VNCQDDGGWTPMIWATEYKH 885
               +   G+  T LH A    H      LL  G +D   V+C+DD G TP+  A    H
Sbjct: 772 F---RKFIGNPFTPLHCAIINDHGNCASLLL--GAIDSSIVSCRDDKGRTPLRAAAFADH 826

Query: 886 VDLVKLLLSKGSDINIRDNEENICLHWAAFSGCVDIAEILL-AAKCDLHAVNIHGDSPLH 944
           V+ ++LLL   + +N  DN     L  AA +G     +IL+ +A+ DL   +   ++PLH
Sbjct: 827 VECLQLLLRHSAPVNAVDNSGKTALMMAAENGQAGAVDILVNSAQADLTVKDKDLNTPLH 886

Query: 945 IAARENRYDCVVLFLSRDSDVTLKNKE 971
           +A  +    C +L L +  D +L N++
Sbjct: 887 LACSKGHEKCALLILDKIQDESLINEK 913



 Score = 73.6 bits (179), Expect = 1e-12
 Identities = 69/271 (25%), Positives = 110/271 (40%), Gaps = 35/271 (12%)

Query: 742 LYFSARQGELQKVLLMLVDGIDPNFKMEHQNKRSPLHAAAEAGHVDICHMLVQAGANIDT 801
           L+ +A  G ++ + L+   G D  F  + +  R+PLH AA   H      LV  GAN++ 
Sbjct: 384 LHAAAAGGNVECIKLLQSSGAD--FHKKDKCGRTPLHYAAANCHFHCIETLVTTGANVNE 441

Query: 802 CSEDQRTPLMEAA----------------------------ENNHLEAVKYLIKAGALVD 833
             +  RT L  AA                            E      +++L++  A   
Sbjct: 442 TDDWGRTALHYAAASDMDRNKTILGNAHDNSEELERARELKEKEATLCLEFLLQNDANPS 501

Query: 834 PKDAEGSTCLHLAAKKGHYEVVQYLLSNGQMDVNCQDDGGW-TPMIWATEYKHVDLVKLL 892
            +D EG   +H AA  GH + ++ LL          D G   +P+  A    H   +++L
Sbjct: 502 IRDKEGYNSIHYAAAYGHRQCLELLLERTNSGFEESDSGATKSPLHLAAYNGHHQALEVL 561

Query: 893 LSKGSDINIRDNEENICLHWAAFSGCVDIAEILLAAKCDLHAV-NIHGDSPLHIAARENR 951
           L    D++IRD +    L  AAF G  +  E L+     +    N+   +PLH +     
Sbjct: 562 LQSLVDLDIRDEKGRTALDLAAFKGHTECVEALINPGASIFVKDNVTKRTPLHASVINGH 621

Query: 952 YDCVVLFL---SRDSDVTLKNKEGETPLQCA 979
             C+ L L        V +K+ +G+TPL  A
Sbjct: 622 TLCLRLLLEIADNPEAVDVKDAKGQTPLMLA 652



 Score = 63.9 bits (154), Expect = 9e-10
 Identities = 43/138 (31%), Positives = 72/138 (52%), Gaps = 2/138 (1%)

Query: 772 NKRSPLHAAAEAGHVDICHMLVQA-GANIDTCSEDQ-RTPLMEAAENNHLEAVKYLIKAG 829
           N  +PLH A    H +   +L+ A  ++I +C +D+ RTPL  AA  +H+E ++ L++  
Sbjct: 778 NPFTPLHCAIINDHGNCASLLLGAIDSSIVSCRDDKGRTPLRAAAFADHVECLQLLLRHS 837

Query: 830 ALVDPKDAEGSTCLHLAAKKGHYEVVQYLLSNGQMDVNCQDDGGWTPMIWATEYKHVDLV 889
           A V+  D  G T L +AA+ G    V  L+++ Q D+  +D    TP+  A    H    
Sbjct: 838 APVNAVDNSGKTALMMAAENGQAGAVDILVNSAQADLTVKDKDLNTPLHLACSKGHEKCA 897

Query: 890 KLLLSKGSDINIRDNEEN 907
            L+L K  D ++ + + N
Sbjct: 898 LLILDKIQDESLINEKNN 915


>gi|103471993 huntingtin interacting protein 14 [Homo sapiens]
          Length = 632

 Score =  112 bits (279), Expect = 3e-24
 Identities = 67/173 (38%), Positives = 93/173 (53%), Gaps = 4/173 (2%)

Query: 777 LHAAAEAGHVDICHMLVQAGANIDTCSED-QRTPLMEAAENNHLEAVKYLIKAGALVDPK 835
           LH AA    +D+    +  GA +D    D   TPL  A    HL  V  L+K GA     
Sbjct: 94  LHWAAINNRIDLVKYYISKGAIVDQLGGDLNSTPLHWATRQGHLSMVVQLMKYGADPSLI 153

Query: 836 DAEGSTCLHLAAKKGHYEVVQYLLSNGQMDVNCQDDGGWTPMIWATEYKH-VDLVKLLLS 894
           D EG +C+HLAA+ GH  +V YL++ GQ DV+  D  G TP++WA    H VD  +LLL+
Sbjct: 154 DGEGCSCIHLAAQFGHTSIVAYLIAKGQ-DVDMMDQNGMTPLMWAAYRTHSVDPTRLLLT 212

Query: 895 KGSDINIRDN-EENICLHWAAFSGCVDIAEILLAAKCDLHAVNIHGDSPLHIA 946
               +N+ D   +N  LHWA  +G   +  +LL A  ++ A NI G+S L +A
Sbjct: 213 FNVSVNLGDKYHKNTALHWAVLAGNTTVISLLLEAGANVDAQNIKGESALDLA 265



 Score = 76.6 bits (187), Expect = 1e-13
 Identities = 60/235 (25%), Positives = 97/235 (41%), Gaps = 35/235 (14%)

Query: 810  LMEAAENNHLEAVKYLIKAGALVDPKDAEGSTCLHLAAKKGHYEVVQYLLSNGQMDVNCQ 869
            +++A +    E  + L++AG  V   D E  T LH AA     ++V+Y +S G +     
Sbjct: 61   IVKATQYGIYERCRELVEAGYDVRQPDKENVTLLHWAAINNRIDLVKYYISKGAIVDQLG 120

Query: 870  DDGGWTPMIWATEYKHVDLVKLLLSKGSDINIRDNEENICLHWAAFSGCVDIAEILLAAK 929
             D   TP+ WAT   H+ +V  L+  G+D ++ D E   C+H AA  G   I   L+A  
Sbjct: 121  GDLNSTPLHWATRQGHLSMVVQLMKYGADPSLIDGEGCSCIHLAAQFGHTSIVAYLIAKG 180

Query: 930  CDL------------------HAVN-----------------IHGDSPLHIAARENRYDC 954
             D+                  H+V+                  H ++ LH A        
Sbjct: 181  QDVDMMDQNGMTPLMWAAYRTHSVDPTRLLLTFNVSVNLGDKYHKNTALHWAVLAGNTTV 240

Query: 955  VVLFLSRDSDVTLKNKEGETPLQCASLNSQVWSALQMSKALQDSAPDRPSPVERI 1009
            + L L   ++V  +N +GE+ L  A     VW    + +A Q    D PS + ++
Sbjct: 241  ISLLLEAGANVDAQNIKGESALDLAKQRKNVWMINHLQEARQAKGYDNPSFLRKL 295



 Score = 58.2 bits (139), Expect = 5e-08
 Identities = 45/153 (29%), Positives = 77/153 (50%), Gaps = 5/153 (3%)

Query: 742 LYFSARQGELQKVLLMLVDGIDPNFKMEHQNKRSPLHAAAEAGHVDICHMLVQAGANIDT 801
           L+++ RQG L  V+ ++  G DP+  +      S +H AA+ GH  I   L+  G ++D 
Sbjct: 128 LHWATRQGHLSMVVQLMKYGADPS--LIDGEGCSCIHLAAQFGHTSIVAYLIAKGQDVDM 185

Query: 802 CSEDQRTPLMEAAENNH-LEAVKYLIKAGALVDPKDA-EGSTCLHLAAKKGHYEVVQYLL 859
             ++  TPLM AA   H ++  + L+     V+  D    +T LH A   G+  V+  LL
Sbjct: 186 MDQNGMTPLMWAAYRTHSVDPTRLLLTFNVSVNLGDKYHKNTALHWAVLAGNTTVISLLL 245

Query: 860 SNGQMDVNCQDDGGWTPMIWATEYKHVDLVKLL 892
             G  +V+ Q+  G + +  A + K+V ++  L
Sbjct: 246 EAG-ANVDAQNIKGESALDLAKQRKNVWMINHL 277



 Score = 43.9 bits (102), Expect = 0.001
 Identities = 29/106 (27%), Positives = 50/106 (47%), Gaps = 5/106 (4%)

Query: 870 DDGGWTPMIWATEYKHVDLVKLLLSKGSDINIRDNEENICLHWAAFSGCVDIAEILLAAK 929
           DD     ++ AT+Y   +  + L+  G D+   D E    LHWAA +  +D+ +  ++  
Sbjct: 54  DDYSTWDIVKATQYGIYERCRELVEAGYDVRQPDKENVTLLHWAAINNRIDLVKYYISKG 113

Query: 930 CDLHAVNIHGD---SPLHIAARENRYDCVVLFLSRDSDVTLKNKEG 972
             +    + GD   +PLH A R+     VV  +   +D +L + EG
Sbjct: 114 AIVD--QLGGDLNSTPLHWATRQGHLSMVVQLMKYGADPSLIDGEG 157



 Score = 31.6 bits (70), Expect = 5.2
 Identities = 20/87 (22%), Positives = 44/87 (50%), Gaps = 1/87 (1%)

Query: 742 LYFSARQGELQKVLLMLVDGIDPNFKMEHQNKRSPLHAAAEAGHVDICHMLVQAGANIDT 801
           ++ + R   +    L+L   +  N   ++ +K + LH A  AG+  +  +L++AGAN+D 
Sbjct: 195 MWAAYRTHSVDPTRLLLTFNVSVNLGDKY-HKNTALHWAVLAGNTTVISLLLEAGANVDA 253

Query: 802 CSEDQRTPLMEAAENNHLEAVKYLIKA 828
            +    + L  A +  ++  + +L +A
Sbjct: 254 QNIKGESALDLAKQRKNVWMINHLQEA 280


>gi|89363047 death-associated protein kinase 1 [Homo sapiens]
          Length = 1430

 Score =  109 bits (272), Expect = 2e-23
 Identities = 69/252 (27%), Positives = 119/252 (47%), Gaps = 34/252 (13%)

Query: 765 NFKMEHQNKRS--PLHAAAEAGHVDICHMLVQAGANIDTCSEDQRTPLMEAAENNHLEAV 822
           N+ +   NK    PL  AA  G++ I  +L++ G+ ID   +     +  AA + H++ +
Sbjct: 369 NYDVNQPNKHGTPPLLIAAGCGNIQILQLLIKRGSRIDVQDKGGSNAVYWAARHGHVDTL 428

Query: 823 KYLIKAGALVDPKDAEGSTCLHLAAKKGHYEVVQYLLSNGQ------------------- 863
           K+L +    +D KD  G   LH+AA+ GH +V Q L S G                    
Sbjct: 429 KFLSENKCPLDVKDKSGEMALHVAARYGHADVAQLLCSFGSNPNIQDKEEETPLHCAAWH 488

Query: 864 -------------MDVNCQDDGGWTPMIWATEYKHVDLVKLLLSKGSDINIRDNEENICL 910
                         +VN ++  G TP++ A+   + D+V+ L   G+D+N  D + +I L
Sbjct: 489 GYYSVAKALCEAGCNVNIKNREGETPLLTASARGYHDIVECLAEHGADLNACDKDGHIAL 548

Query: 911 HWAAFSGCVDIAEILLAAKCDLHAVNIHGDSPLHIAARENRYDCVVLFLSRDSDVTLKNK 970
           H A     +++ + LL+  C +   + HG++PLH+A ++     VV     + ++ + NK
Sbjct: 549 HLAVRRCQMEVIKTLLSQGCFVDYQDRHGNTPLHVACKDGNMPIVVALCEANCNLDISNK 608

Query: 971 EGETPLQCASLN 982
            G TPL  A+ N
Sbjct: 609 YGRTPLHLAANN 620



 Score =  108 bits (271), Expect = 3e-23
 Identities = 79/279 (28%), Positives = 132/279 (47%), Gaps = 3/279 (1%)

Query: 696 FDPTGPAGLGRPTPGLSQGPGKETLESALIALDSEKPKKLRFHPKQLYFSARQGELQKVL 755
           +D   P   G P   ++ G G   +   LI   S    + +     +Y++AR G +   L
Sbjct: 370 YDVNQPNKHGTPPLLIAAGCGNIQILQLLIKRGSRIDVQDKGGSNAVYWAARHGHVD-TL 428

Query: 756 LMLVDGIDPNFKMEHQNKRSPLHAAAEAGHVDICHMLVQAGANIDTCSEDQRTPLMEAAE 815
             L +   P   ++ ++    LH AA  GH D+  +L   G+N +   +++ TPL  AA 
Sbjct: 429 KFLSENKCP-LDVKDKSGEMALHVAARYGHADVAQLLCSFGSNPNIQDKEEETPLHCAAW 487

Query: 816 NNHLEAVKYLIKAGALVDPKDAEGSTCLHLAAKKGHYEVVQYLLSNGQMDVNCQDDGGWT 875
           + +    K L +AG  V+ K+ EG T L  A+ +G++++V+ L  +G  D+N  D  G  
Sbjct: 488 HGYYSVAKALCEAGCNVNIKNREGETPLLTASARGYHDIVECLAEHGA-DLNACDKDGHI 546

Query: 876 PMIWATEYKHVDLVKLLLSKGSDINIRDNEENICLHWAAFSGCVDIAEILLAAKCDLHAV 935
            +  A     ++++K LLS+G  ++ +D   N  LH A   G + I   L  A C+L   
Sbjct: 547 ALHLAVRRCQMEVIKTLLSQGCFVDYQDRHGNTPLHVACKDGNMPIVVALCEANCNLDIS 606

Query: 936 NIHGDSPLHIAARENRYDCVVLFLSRDSDVTLKNKEGET 974
           N +G +PLH+AA     D V       + V     +G+T
Sbjct: 607 NKYGRTPLHLAANNGILDVVRYLCLMGASVEALTTDGKT 645



 Score = 97.4 bits (241), Expect = 8e-20
 Identities = 56/177 (31%), Positives = 96/177 (54%), Gaps = 1/177 (0%)

Query: 809 PLMEAAENNHLEAVKYLIKAGALVDPKDAEGSTCLHLAAKKGHYEVVQYLLSNGQMDVNC 868
           PL+ AA   +++ ++ LIK G+ +D +D  GS  ++ AA+ GH + +++L  N +  ++ 
Sbjct: 382 PLLIAAGCGNIQILQLLIKRGSRIDVQDKGGSNAVYWAARHGHVDTLKFLSEN-KCPLDV 440

Query: 869 QDDGGWTPMIWATEYKHVDLVKLLLSKGSDINIRDNEENICLHWAAFSGCVDIAEILLAA 928
           +D  G   +  A  Y H D+ +LL S GS+ NI+D EE   LH AA+ G   +A+ L  A
Sbjct: 441 KDKSGEMALHVAARYGHADVAQLLCSFGSNPNIQDKEEETPLHCAAWHGYYSVAKALCEA 500

Query: 929 KCDLHAVNIHGDSPLHIAARENRYDCVVLFLSRDSDVTLKNKEGETPLQCASLNSQV 985
            C+++  N  G++PL  A+    +D V       +D+   +K+G   L  A    Q+
Sbjct: 501 GCNVNIKNREGETPLLTASARGYHDIVECLAEHGADLNACDKDGHIALHLAVRRCQM 557



 Score = 82.4 bits (202), Expect = 3e-15
 Identities = 50/175 (28%), Positives = 92/175 (52%), Gaps = 7/175 (4%)

Query: 810 LMEAAENNHLEAVKYLIKAGAL----VDPKDAEGSTCLHLAAKKGHYEVVQYLLSNGQMD 865
           ++ A  ++++  +++L+  G+L    V+  +  G+  L +AA  G+ +++Q L+  G   
Sbjct: 348 IIHAINDDNVPGLQHLL--GSLSNYDVNQPNKHGTPPLLIAAGCGNIQILQLLIKRGSR- 404

Query: 866 VNCQDDGGWTPMIWATEYKHVDLVKLLLSKGSDINIRDNEENICLHWAAFSGCVDIAEIL 925
           ++ QD GG   + WA  + HVD +K L      ++++D    + LH AA  G  D+A++L
Sbjct: 405 IDVQDKGGSNAVYWAARHGHVDTLKFLSENKCPLDVKDKSGEMALHVAARYGHADVAQLL 464

Query: 926 LAAKCDLHAVNIHGDSPLHIAARENRYDCVVLFLSRDSDVTLKNKEGETPLQCAS 980
            +   + +  +   ++PLH AA    Y           +V +KN+EGETPL  AS
Sbjct: 465 CSFGSNPNIQDKEEETPLHCAAWHGYYSVAKALCEAGCNVNIKNREGETPLLTAS 519



 Score = 61.6 bits (148), Expect = 5e-09
 Identities = 37/117 (31%), Positives = 61/117 (52%), Gaps = 2/117 (1%)

Query: 742 LYFSARQGELQKVLLMLVDGIDPNFKMEHQNKRSPLHAAAEAGHVDICHMLVQAGANIDT 801
           L+ + R+ +++ +  +L  G   +++  H N  +PLH A + G++ I   L +A  N+D 
Sbjct: 548 LHLAVRRCQMEVIKTLLSQGCFVDYQDRHGN--TPLHVACKDGNMPIVVALCEANCNLDI 605

Query: 802 CSEDQRTPLMEAAENNHLEAVKYLIKAGALVDPKDAEGSTCLHLAAKKGHYEVVQYL 858
            ++  RTPL  AA N  L+ V+YL   GA V+    +G T   LA  + H  V   L
Sbjct: 606 SNKYGRTPLHLAANNGILDVVRYLCLMGASVEALTTDGKTAEDLARSEQHEHVAGLL 662


>gi|224177469 SET domain, bifurcated 1 isoform 2 [Homo sapiens]
          Length = 1290

 Score =  108 bits (271), Expect = 3e-23
 Identities = 65/180 (36%), Positives = 97/180 (53%), Gaps = 14/180 (7%)

Query: 1013 DIARGYERIPIPCVNAVDSEPCPSNYKYVSQNCVTSPMNIDRNITHLQYCVCIDDC-SSS 1071
            DI  G E +P+ CVN +D+ P P    Y  +      + I+     L  C C D C   S
Sbjct: 681  DITYGKEDVPLSCVNEIDTTP-PPQVAYSKERIPGKGVFINTGPEFLVGCDCKDGCRDKS 739

Query: 1072 NCMCGQLSMRCWY-DKDGRLLP----EFNMAE---PPLIFECNHACSCWRN-CRNRVVQN 1122
             C C QL+++       G++ P    ++   E   P  ++ECN  C C  N C NR+VQ+
Sbjct: 740  KCACHQLTIQATACTPGGQINPNSGYQYKRLEECLPTGVYECNKRCKCDPNMCTNRLVQH 799

Query: 1123 GLRARLQLYRTRDMGWGVRSLQDIPPGTFVCEYVGELISDSEAD---VREEDSYLFDLDN 1179
            GL+ RLQL++T++ GWG+R L DI  G+FVC Y G++++D  AD   +   D Y  +LD+
Sbjct: 800  GLQVRLQLFKTQNKGWGIRCLDDIAKGSFVCIYAGKILTDDFADKEGLEMGDEYFANLDH 859



 Score = 79.0 bits (193), Expect = 3e-14
 Identities = 39/86 (45%), Positives = 54/86 (62%), Gaps = 3/86 (3%)

Query: 1181 DGEVYC--IDARFYGNVSRFINHHCEPNLVPVRVFMAHQDLRFPRIAFFSTRLIEAGEQL 1238
            DGE  C  IDA+  GN+ R++NH C PNL    VF+   DLRFP +AFF+++ I AG +L
Sbjct: 1202 DGEESCYIIDAKLEGNLGRYLNHSCSPNLFVQNVFVDTHDLRFPWVAFFASK-IRAGTEL 1260

Query: 1239 GFDYGERFWDIKGKLFSCRCGSPKCR 1264
             +DY      ++GK   C CG+ +CR
Sbjct: 1261 TWDYNYEVGSVEGKELLCCCGAIECR 1286


>gi|224177467 SET domain, bifurcated 1 isoform 1 [Homo sapiens]
          Length = 1291

 Score =  108 bits (271), Expect = 3e-23
 Identities = 65/180 (36%), Positives = 97/180 (53%), Gaps = 14/180 (7%)

Query: 1013 DIARGYERIPIPCVNAVDSEPCPSNYKYVSQNCVTSPMNIDRNITHLQYCVCIDDC-SSS 1071
            DI  G E +P+ CVN +D+ P P    Y  +      + I+     L  C C D C   S
Sbjct: 681  DITYGKEDVPLSCVNEIDTTP-PPQVAYSKERIPGKGVFINTGPEFLVGCDCKDGCRDKS 739

Query: 1072 NCMCGQLSMRCWY-DKDGRLLP----EFNMAE---PPLIFECNHACSCWRN-CRNRVVQN 1122
             C C QL+++       G++ P    ++   E   P  ++ECN  C C  N C NR+VQ+
Sbjct: 740  KCACHQLTIQATACTPGGQINPNSGYQYKRLEECLPTGVYECNKRCKCDPNMCTNRLVQH 799

Query: 1123 GLRARLQLYRTRDMGWGVRSLQDIPPGTFVCEYVGELISDSEAD---VREEDSYLFDLDN 1179
            GL+ RLQL++T++ GWG+R L DI  G+FVC Y G++++D  AD   +   D Y  +LD+
Sbjct: 800  GLQVRLQLFKTQNKGWGIRCLDDIAKGSFVCIYAGKILTDDFADKEGLEMGDEYFANLDH 859



 Score = 82.8 bits (203), Expect = 2e-15
 Identities = 39/86 (45%), Positives = 54/86 (62%), Gaps = 2/86 (2%)

Query: 1181 DGEVYC--IDARFYGNVSRFINHHCEPNLVPVRVFMAHQDLRFPRIAFFSTRLIEAGEQL 1238
            DGE  C  IDA+  GN+ R++NH C PNL    VF+   DLRFP +AFF+++ I AG +L
Sbjct: 1202 DGEESCYIIDAKLEGNLGRYLNHSCSPNLFVQNVFVDTHDLRFPWVAFFASKRIRAGTEL 1261

Query: 1239 GFDYGERFWDIKGKLFSCRCGSPKCR 1264
             +DY      ++GK   C CG+ +CR
Sbjct: 1262 TWDYNYEVGSVEGKELLCCCGAIECR 1287


>gi|46519147 ankyrin repeat and KH domain containing 1 isoform 1
           [Homo sapiens]
          Length = 2542

 Score =  108 bits (270), Expect = 3e-23
 Identities = 76/236 (32%), Positives = 122/236 (51%), Gaps = 12/236 (5%)

Query: 749 GELQKVLLMLVDGIDPNFKMEHQNKRSPLHAAAEAGHVDICHMLVQAGANIDTCSEDQRT 808
           G ++   L+L  G   N  M   +  SPL  AA  GHV++  +L++ GAN++  +++  T
Sbjct: 416 GHVEVARLLLDSGAQVN--MPADSFESPLTLAACGGHVELAALLIERGANLEEVNDEGYT 473

Query: 809 PLMEAAENNHLEAVKYLIKAGALVDPKDAEGS-TCLHLAAKKGHYEVVQYLLSNG-QMDV 866
           PLMEAA   H E V  L+  GA ++ +  E   T L LA   G  EV  +L+  G  +++
Sbjct: 474 PLMEAAREGHEEMVALLLAQGANINAQTEETQETALTLACCGGFSEVADFLIKAGADIEL 533

Query: 867 NCQDDGGWTPMIWATEYKHVDLVKLLLSKGSDINIRDNEENICLHWAAFSGCVDIAEILL 926
            C      TP++ A++  H++LVK LL+ G++++      +  L +A  +G  D+A++LL
Sbjct: 534 GCS-----TPLMEASQEGHLELVKYLLASGANVHATTATGDTALTYACENGHTDVADVLL 588

Query: 927 AAKCDLHAVNIHGDSPLHIAARENRYDCVVLFLSRDSDV---TLKNKEGETPLQCA 979
            A  DL   +  G +PL  AAR      V   +S+ ++V   T  N      L CA
Sbjct: 589 QAGADLEHESEGGRTPLMKAARAGHLCTVQFLISKGANVNRATANNDHTVVSLACA 644



 Score = 97.8 bits (242), Expect = 6e-20
 Identities = 72/239 (30%), Positives = 124/239 (51%), Gaps = 8/239 (3%)

Query: 745 SARQGELQKVLLMLVDGIDPNFKMEHQNKRSPLHAAAEAGHVDICHMLVQAGANIDTCSE 804
           SA   E+ +VLL    GI+ +    ++ K S L  A   GH+D+   L++AGA+ +  ++
Sbjct: 347 SAGHVEVARVLLDHGAGINTH---SNEFKESALTLACYKGHLDMVRFLLEAGADQEHKTD 403

Query: 805 DQRTPLMEAAENNHLEAVKYLIKAGALVDPKDAEGSTCLHLAAKKGHYEVVQYLLSNGQM 864
           +  T LMEA  + H+E  + L+ +GA V+       + L LAA  GH E+   L+  G  
Sbjct: 404 EMHTALMEACMDGHVEVARLLLDSGAQVNMPADSFESPLTLAACGGHVELAALLIERG-A 462

Query: 865 DVNCQDDGGWTPMIWATEYKHVDLVKLLLSKGSDINIRDNE-ENICLHWAAFSGCVDIAE 923
           ++   +D G+TP++ A    H ++V LLL++G++IN +  E +   L  A   G  ++A+
Sbjct: 463 NLEEVNDEGYTPLMEAAREGHEEMVALLLAQGANINAQTEETQETALTLACCGGFSEVAD 522

Query: 924 ILLAAKCDLHAVNIHGDSPLHIAARENRYDCVVLFLSRDSDVTLKNKEGETPLQCASLN 982
            L+ A  D   + +   +PL  A++E   + V   L+  ++V      G+T L  A  N
Sbjct: 523 FLIKAGAD---IELGCSTPLMEASQEGHLELVKYLLASGANVHATTATGDTALTYACEN 578



 Score = 97.1 bits (240), Expect = 1e-19
 Identities = 85/272 (31%), Positives = 130/272 (47%), Gaps = 11/272 (4%)

Query: 716  GKETLESALIALDS--EKPKKLRFHPKQLYFSARQGELQKVLLMLVDGIDPNFKMEHQNK 773
            G E L S LIA D+  E   K  F P  L  +A  G +  V ++L  G D   + E + K
Sbjct: 1066 GHEELVSVLIARDAKIEHRDKKGFTP--LILAATAGHVGVVEILLDKGGDIEAQSE-RTK 1122

Query: 774  RSPLHAAAEAGHVDICHMLVQAGANIDTCSEDQRTPLMEAAENNHLEAVKYLIKAGALVD 833
             +PL  A   G  ++  +L+  GAN +  +    TPL  AA   ++  +K L+ AGA ++
Sbjct: 1123 DTPLSLACSGGRQEVVDLLLARGANKEHRNVSDYTPLSLAASGGYVNIIKILLNAGAEIN 1182

Query: 834  PKDAE--GSTCLHLAAKKGHYEVVQYLLSNGQMDVNCQ-DDGGWTPMIWATEYKHVDLVK 890
             +     G + L LAA  GH   V+ LL  G  D+N Q +    T +  A      ++V 
Sbjct: 1183 SRTGSKLGISPLMLAAMNGHVPAVKLLLDMGS-DINAQIETNRNTALTLACFQGRAEVVS 1241

Query: 891  LLLSKGSDINIRDNEENICLHWAAFSGCVDIAEILLAAKCDLHA--VNIHGDSPLHIAAR 948
            LLL + +++  R       L  AA  G  ++  +LL    D++A  V    D+ L IAA 
Sbjct: 1242 LLLDRKANVEHRAKTGLTPLMEAASGGYAEVGRVLLDKGADVNAPPVPSSRDTALTIAAD 1301

Query: 949  ENRYDCVVLFLSRDSDVTLKNKEGETPLQCAS 980
            +  Y    L + R + + ++NK+G TPL  AS
Sbjct: 1302 KGHYKFCELLIHRGAHIDVRNKKGNTPLWLAS 1333



 Score = 92.0 bits (227), Expect = 3e-18
 Identities = 69/237 (29%), Positives = 117/237 (49%), Gaps = 5/237 (2%)

Query: 745 SARQGELQKVLLMLVDGIDPNFKMEHQNKRSPLHAAAEAGHVDICHMLVQAGANIDTCSE 804
           SA   EL +VLL +   ++      ++   +PL AA+  G++DI  +L+   A++++ S 
Sbjct: 247 SAGYYELAQVLLAMHANVEDR---GNKGDITPLMAASSGGYLDIVKLLLLHDADVNSQSA 303

Query: 805 DQRTPLMEAAENNHLEAVKYLIKAGALVDPKDAEGSTCLHLAAKKGHYEVVQYLLSNGQM 864
              T L  A     ++ VK L+  GA ++  +  G T L  AA  GH EV + LL +G  
Sbjct: 304 TGNTALTYACAGGFVDIVKVLLNEGANIEDHNENGHTPLMEAASAGHVEVARVLLDHG-A 362

Query: 865 DVNCQDDGGWTPMIWATEYK-HVDLVKLLLSKGSDINIRDNEENICLHWAAFSGCVDIAE 923
            +N   +      +    YK H+D+V+ LL  G+D   + +E +  L  A   G V++A 
Sbjct: 363 GINTHSNEFKESALTLACYKGHLDMVRFLLEAGADQEHKTDEMHTALMEACMDGHVEVAR 422

Query: 924 ILLAAKCDLHAVNIHGDSPLHIAARENRYDCVVLFLSRDSDVTLKNKEGETPLQCAS 980
           +LL +   ++      +SPL +AA     +   L + R +++   N EG TPL  A+
Sbjct: 423 LLLDSGAQVNMPADSFESPLTLAACGGHVELAALLIERGANLEEVNDEGYTPLMEAA 479



 Score = 92.0 bits (227), Expect = 3e-18
 Identities = 75/238 (31%), Positives = 121/238 (50%), Gaps = 12/238 (5%)

Query: 749  GELQKVLLMLVDGIDPNFKMEHQNKR--SPLHAAAEAGHVDICHMLVQAGANID--TCSE 804
            G  + V L+L  G +     EH+N    +PL  AA  G+V+I  +L+ AGA I+  T S+
Sbjct: 1133 GRQEVVDLLLARGANK----EHRNVSDYTPLSLAASGGYVNIIKILLNAGAEINSRTGSK 1188

Query: 805  DQRTPLMEAAENNHLEAVKYLIKAGALVDPK-DAEGSTCLHLAAKKGHYEVVQYLLSNGQ 863
               +PLM AA N H+ AVK L+  G+ ++ + +   +T L LA  +G  EVV  LL   +
Sbjct: 1189 LGISPLMLAAMNGHVPAVKLLLDMGSDINAQIETNRNTALTLACFQGRAEVVSLLLDR-K 1247

Query: 864  MDVNCQDDGGWTPMIWATEYKHVDLVKLLLSKGSDINIRD--NEENICLHWAAFSGCVDI 921
             +V  +   G TP++ A    + ++ ++LL KG+D+N     +  +  L  AA  G    
Sbjct: 1248 ANVEHRAKTGLTPLMEAASGGYAEVGRVLLDKGADVNAPPVPSSRDTALTIAADKGHYKF 1307

Query: 922  AEILLAAKCDLHAVNIHGDSPLHIAARENRYDCVVLFLSRDSDVTLKNKEGETPLQCA 979
             E+L+     +   N  G++PL +A+    +D V L +   +DV   +    TPL  A
Sbjct: 1308 CELLIHRGAHIDVRNKKGNTPLWLASNGGHFDVVQLLVQAGADVDAADNRKITPLMSA 1365



 Score = 86.3 bits (212), Expect = 2e-16
 Identities = 62/202 (30%), Positives = 104/202 (51%), Gaps = 6/202 (2%)

Query: 727  LDSEKPKKLRFHPKQLYFSARQGELQKVLLMLVDGIDPNFKMEHQNKRSPLHAAAEAGHV 786
            ++S    KL   P  L  +A  G +  V L+L  G D N ++E  N+ + L  A   G  
Sbjct: 1181 INSRTGSKLGISP--LMLAAMNGHVPAVKLLLDMGSDINAQIE-TNRNTALTLACFQGRA 1237

Query: 787  DICHMLVQAGANIDTCSEDQRTPLMEAAENNHLEAVKYLIKAGALVD--PKDAEGSTCLH 844
            ++  +L+   AN++  ++   TPLMEAA   + E  + L+  GA V+  P  +   T L 
Sbjct: 1238 EVVSLLLDRKANVEHRAKTGLTPLMEAASGGYAEVGRVLLDKGADVNAPPVPSSRDTALT 1297

Query: 845  LAAKKGHYEVVQYLLSNGQMDVNCQDDGGWTPMIWATEYKHVDLVKLLLSKGSDINIRDN 904
            +AA KGHY+  + L+  G   ++ ++  G TP+  A+   H D+V+LL+  G+D++  DN
Sbjct: 1298 IAADKGHYKFCELLIHRGA-HIDVRNKKGNTPLWLASNGGHFDVVQLLVQAGADVDAADN 1356

Query: 905  EENICLHWAAFSGCVDIAEILL 926
             +   L  A   G V + + L+
Sbjct: 1357 RKITPLMSAFRKGHVKVVQYLV 1378



 Score = 80.1 bits (196), Expect = 1e-14
 Identities = 73/249 (29%), Positives = 120/249 (48%), Gaps = 12/249 (4%)

Query: 772  NKRSPLHAAAEAGHVDICHMLVQAGANIDTCSEDQRTPLMEAAENNHLEAVKYLI-KAGA 830
            N  + L  A   GH ++  +L+   A I+   +   TPL+ AA   H+  V+ L+ K G 
Sbjct: 1054 NHDTALTLACAGGHEELVSVLIARDAKIEHRDKKGFTPLILAATAGHVGVVEILLDKGGD 1113

Query: 831  LVDPKDAEGSTCLHLAAKKGHYEVVQYLLSNGQMDVNCQDDGGWTPMIWATEYKHVDLVK 890
            +    +    T L LA   G  EVV  LL+ G  +   ++   +TP+  A    +V+++K
Sbjct: 1114 IEAQSERTKDTPLSLACSGGRQEVVDLLLARG-ANKEHRNVSDYTPLSLAASGGYVNIIK 1172

Query: 891  LLLSKGSDINIRDNEE--NICLHWAAFSGCVDIAEILLAAKCDLHA-VNIHGDSPLHIAA 947
            +LL+ G++IN R   +     L  AA +G V   ++LL    D++A +  + ++ L +A 
Sbjct: 1173 ILLNAGAEINSRTGSKLGISPLMLAAMNGHVPAVKLLLDMGSDINAQIETNRNTALTLAC 1232

Query: 948  RENRYDCVVLFLSRDSDVTLKNKEGETPL-QCASLNSQVWSALQMSKALQDSAPDRPSPV 1006
             + R + V L L R ++V  + K G TPL + AS        + + K    +AP  PS  
Sbjct: 1233 FQGRAEVVSLLLDRKANVEHRAKTGLTPLMEAASGGYAEVGRVLLDKGADVNAPPVPS-- 1290

Query: 1007 ERIVSRDIA 1015
                SRD A
Sbjct: 1291 ----SRDTA 1295



 Score = 77.0 bits (188), Expect = 1e-13
 Identities = 54/156 (34%), Positives = 83/156 (53%), Gaps = 4/156 (2%)

Query: 745 SARQGELQKVLLMLVDGIDPNFKMEHQNKRSPLHAAAEAGHVDICHMLVQAGANIDTCSE 804
           ++++G L+ V  +L  G   N         + L  A E GH D+  +L+QAGA+++  SE
Sbjct: 542 ASQEGHLELVKYLLASGA--NVHATTATGDTALTYACENGHTDVADVLLQAGADLEHESE 599

Query: 805 DQRTPLMEAAENNHLEAVKYLIKAGALVDPKDAEGS-TCLHLAAKKGHYEVVQYLLSNGQ 863
             RTPLM+AA   HL  V++LI  GA V+   A    T + LA   GH  VV+ LL++G 
Sbjct: 600 GGRTPLMKAARAGHLCTVQFLISKGANVNRATANNDHTVVSLACAGGHLAVVELLLAHGA 659

Query: 864 MDVNCQDDGGWTPMIWATEYKHVDLVKLLLSKGSDI 899
              +   DG  T +I A +  H ++V  LL   +++
Sbjct: 660 DPTHRLKDGS-TMLIEAAKGGHTNVVSYLLDYPNNV 694



 Score = 76.3 bits (186), Expect = 2e-13
 Identities = 64/216 (29%), Positives = 98/216 (45%), Gaps = 39/216 (18%)

Query: 745 SARQGELQKVLLMLVDGIDPNFKMEHQNKRSPLHAAAEAGHVDICHMLVQAGANIDT-CS 803
           +AR+G  + V L+L  G + N + E + + + L  A   G  ++   L++AGA+I+  CS
Sbjct: 478 AAREGHEEMVALLLAQGANINAQTE-ETQETALTLACCGGFSEVADFLIKAGADIELGCS 536

Query: 804 EDQRTPLMEAAENNHLEAVKYLIKAGALVDPKDAEGSTCLHLAAKKGHYEV--------- 854
               TPLMEA++  HLE VKYL+ +GA V    A G T L  A + GH +V         
Sbjct: 537 ----TPLMEASQEGHLELVKYLLASGANVHATTATGDTALTYACENGHTDVADVLLQAGA 592

Query: 855 ------------------------VQYLLSNGQMDVNCQDDGGWTPMIWATEYKHVDLVK 890
                                   VQ+L+S G        +   T +  A    H+ +V+
Sbjct: 593 DLEHESEGGRTPLMKAARAGHLCTVQFLISKGANVNRATANNDHTVVSLACAGGHLAVVE 652

Query: 891 LLLSKGSDINIRDNEENICLHWAAFSGCVDIAEILL 926
           LLL+ G+D   R  + +  L  AA  G  ++   LL
Sbjct: 653 LLLAHGADPTHRLKDGSTMLIEAAKGGHTNVVSYLL 688



 Score = 72.0 bits (175), Expect = 3e-12
 Identities = 45/127 (35%), Positives = 66/127 (51%), Gaps = 4/127 (3%)

Query: 746  ARQGELQKVLLMLVD-GIDPNFKMEHQNKRSPLHAAAEAGHVDICHMLVQAGANIDTCSE 804
            A  G   +V  +L+D G D N      ++ + L  AA+ GH   C +L+  GA+ID  ++
Sbjct: 1264 AASGGYAEVGRVLLDKGADVNAPPVPSSRDTALTIAADKGHYKFCELLIHRGAHIDVRNK 1323

Query: 805  DQRTPLMEAAENNHLEAVKYLIKAGALVDPKDAEGSTCLHLAAKKGHYEVVQYLLSNGQM 864
               TPL  A+   H + V+ L++AGA VD  D    T L  A +KGH +VVQYL+     
Sbjct: 1324 KGNTPLWLASNGGHFDVVQLLVQAGADVDAADNRKITPLMSAFRKGHVKVVQYLVKEVNQ 1383

Query: 865  ---DVNC 868
               D+ C
Sbjct: 1384 FPSDIEC 1390



 Score = 71.2 bits (173), Expect = 6e-12
 Identities = 67/209 (32%), Positives = 98/209 (46%), Gaps = 8/209 (3%)

Query: 793  VQAGANIDTCSEDQR-TPLMEAAENNHLEAVKYLIKAGALVDPKDAEGSTCLHLAAKKGH 851
            V    +ID  +E    T L  A    H E V  LI   A ++ +D +G T L LAA  GH
Sbjct: 1041 VYPSVDIDAHTESNHDTALTLACAGGHEELVSVLIARDAKIEHRDKKGFTPLILAATAGH 1100

Query: 852  YEVVQYLLSNGQMDVNCQDDGGW-TPMIWATEYKHVDLVKLLLSKGSDINIRDNEENICL 910
              VV+ LL  G  D+  Q +    TP+  A      ++V LLL++G++   R+  +   L
Sbjct: 1101 VGVVEILLDKGG-DIEAQSERTKDTPLSLACSGGRQEVVDLLLARGANKEHRNVSDYTPL 1159

Query: 911  HWAAFSGCVDIAEILLAAKCDLHA--VNIHGDSPLHIAARENRYDCVVLFLSRDSDVTLK 968
              AA  G V+I +ILL A  ++++   +  G SPL +AA       V L L   SD+  +
Sbjct: 1160 SLAASGGYVNIIKILLNAGAEINSRTGSKLGISPLMLAAMNGHVPAVKLLLDMGSDINAQ 1219

Query: 969  ---NKEGETPLQCASLNSQVWSALQMSKA 994
               N+     L C    ++V S L   KA
Sbjct: 1220 IETNRNTALTLACFQGRAEVVSLLLDRKA 1248



 Score = 71.2 bits (173), Expect = 6e-12
 Identities = 49/152 (32%), Positives = 83/152 (54%), Gaps = 9/152 (5%)

Query: 748  QGELQKVLLMLVDGIDPNFKMEHQNKR--SPLHAAAEAGHVDICHMLVQAGANIDT--CS 803
            QG  + V L+L    D    +EH+ K   +PL  AA  G+ ++  +L+  GA+++     
Sbjct: 1234 QGRAEVVSLLL----DRKANVEHRAKTGLTPLMEAASGGYAEVGRVLLDKGADVNAPPVP 1289

Query: 804  EDQRTPLMEAAENNHLEAVKYLIKAGALVDPKDAEGSTCLHLAAKKGHYEVVQYLLSNGQ 863
              + T L  AA+  H +  + LI  GA +D ++ +G+T L LA+  GH++VVQ L+  G 
Sbjct: 1290 SSRDTALTIAADKGHYKFCELLIHRGAHIDVRNKKGNTPLWLASNGGHFDVVQLLVQAGA 1349

Query: 864  MDVNCQDDGGWTPMIWATEYKHVDLVKLLLSK 895
             DV+  D+   TP++ A    HV +V+ L+ +
Sbjct: 1350 -DVDAADNRKITPLMSAFRKGHVKVVQYLVKE 1380



 Score = 70.9 bits (172), Expect = 8e-12
 Identities = 64/237 (27%), Positives = 107/237 (45%), Gaps = 7/237 (2%)

Query: 777  LHAAAEAGHVDICHMLVQAGANIDTCSEDQRTPLMEAAENNHLEAVKYLIKAGALVDPKD 836
            L  A   G V+    L+  G +++  +E+  + L  A    + E  + L+   A V+ + 
Sbjct: 209  LAEACSDGDVNAVRKLLDEGRSVNEHTEEGESLLCLACSAGYYELAQVLLAMHANVEDRG 268

Query: 837  AEGSTCLHLAAKKGHYEVVQYLLSNGQMDVNCQDDGGWTPMIWATEYKHVDLVKLLLSKG 896
             +G     +AA  G Y  +  LL     DVN Q   G T + +A     VD+VK+LL++G
Sbjct: 269  NKGDITPLMAASSGGYLDIVKLLLLHDADVNSQSATGNTALTYACAGGFVDIVKVLLNEG 328

Query: 897  SDINIRDNEENICLHWAAFSGCVDIAEILL--AAKCDLHAVNIHGDSPLHIAARENRYDC 954
            ++I   +   +  L  AA +G V++A +LL   A  + H+ N   +S L +A  +   D 
Sbjct: 329  ANIEDHNENGHTPLMEAASAGHVEVARVLLDHGAGINTHS-NEFKESALTLACYKGHLDM 387

Query: 955  VVLFLSRDSDVTLKNKEGETPLQCASLNSQVWSALQMSKALQDSAPDRPSPVERIVS 1011
            V   L   +D   K  E  T L  A ++  V    ++++ L DS      P +   S
Sbjct: 388  VRFLLEAGADQEHKTDEMHTALMEACMDGHV----EVARLLLDSGAQVNMPADSFES 440


  Database: hs.faa
    Posted date:  Aug 4, 2009  4:42 PM
  Number of letters in database: 18,247,518
  Number of sequences in database:  37,866
  
Lambda     K      H
   0.314    0.129    0.385 

Gapped
Lambda     K      H
   0.267   0.0410    0.140 


Matrix: BLOSUM62
Gap Penalties: Existence: 11, Extension: 1
Number of Hits to DB: 53,965,575
Number of Sequences: 37866
Number of extensions: 2766707
Number of successful extensions: 21817
Number of sequences better than 10.0: 30
Number of HSP's better than 10.0 without gapping: 509
Number of HSP's successfully gapped in prelim test: 491
Number of HSP's that attempted gapping in prelim test: 12138
Number of HSP's gapped (non-prelim): 5097
length of query: 1298
length of database: 18,247,518
effective HSP length: 114
effective length of query: 1184
effective length of database: 13,930,794
effective search space: 16494060096
effective search space used: 16494060096
T: 11
A: 40
X1: 16 ( 7.2 bits)
X2: 38 (14.6 bits)
X3: 64 (24.7 bits)
S1: 42 (21.9 bits)
S2: 68 (30.8 bits)

Search results were obtained with NCBI BLAST and RefSeq entries.

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Guide to the Human Genome
Copyright © 2010 by Stewart Scherer. All rights reserved.