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Search of human proteins with 224458290
BLASTP 2.2.11 [Jun-05-2005]
Reference: Altschul, Stephen F., Thomas L. Madden, Alejandro A. Schaffer,
Jinghui Zhang, Zheng Zhang, Webb Miller, and David J. Lipman (1997),
"Gapped BLAST and PSI-BLAST: a new generation of protein database search
programs", Nucleic Acids Res. 25:3389-3402.
Query= gi|224458290 lipoxygenase homology domains 1 isoform 3 [Homo
sapiens]
(512 letters)
Database: hs.faa
37,866 sequences; 18,247,518 total letters
Searching..................................................done
Score E
Sequences producing significant alignments: (bits) Value
gi|239050813 lipoxygenase homology domains 1 isoform 1 [Homo sap... 1060 0.0
gi|224458290 lipoxygenase homology domains 1 isoform 3 [Homo sap... 1060 0.0
gi|224458288 lipoxygenase homology domains 1 isoform 2 [Homo sap... 933 0.0
gi|239754889 PREDICTED: similar to hCG2036697 [Homo sapiens] 96 8e-20
gi|239749428 PREDICTED: hypothetical protein XP_002347033 [Homo ... 96 8e-20
gi|239743562 PREDICTED: hypothetical protein XP_002342894 [Homo ... 96 8e-20
gi|19923084 polycystin-1L1 [Homo sapiens] 79 8e-15
gi|239756622 PREDICTED: polycystic kidney disease 1-like 3 [Homo... 79 1e-14
gi|239751108 PREDICTED: polycystic kidney disease 1-like 3 [Homo... 79 1e-14
gi|239745596 PREDICTED: polycystin 1-like 3 [Homo sapiens] 79 1e-14
gi|31559825 polycystin 1-like 3 [Homo sapiens] 79 1e-14
gi|205360962 polycystin 1 isoform 2 precursor [Homo sapiens] 75 1e-13
gi|205360954 polycystin 1 isoform 1 precursor [Homo sapiens] 75 1e-13
gi|116006951 polycystin 1-like 2 isoform a [Homo sapiens] 75 2e-13
gi|44889475 RAB6 interacting protein 1 [Homo sapiens] 64 3e-10
gi|122891862 DENN/MADD domain containing 5B [Homo sapiens] 61 2e-09
gi|5174633 receptor for egg jelly-like protein precursor [Homo s... 60 4e-09
gi|4502057 arachidonate 5-lipoxygenase [Homo sapiens] 51 2e-06
gi|182765464 arachidonate lipoxygenase 3 [Homo sapiens] 46 7e-05
gi|4502053 arachidonate 12-lipoxygenase, 12R type [Homo sapiens] 33 0.47
gi|154426292 arachidonate 12-lipoxygenase [Homo sapiens] 32 1.4
gi|44889963 CD163 antigen isoform b [Homo sapiens] 30 5.2
gi|44662834 CD163 antigen isoform a [Homo sapiens] 30 5.2
gi|40316937 arachidonate 15-lipoxygenase [Homo sapiens] 30 6.8
>gi|239050813 lipoxygenase homology domains 1 isoform 1 [Homo sapiens]
Length = 2211
Score = 1060 bits (2741), Expect = 0.0
Identities = 512/512 (100%), Positives = 512/512 (100%)
Query: 1 MTVWTGDVVGGGTDSNIFMTLYGINGSTEEMQLDKKKARFEREQNDTFIMEILDIAPFTK 60
MTVWTGDVVGGGTDSNIFMTLYGINGSTEEMQLDKKKARFEREQNDTFIMEILDIAPFTK
Sbjct: 1700 MTVWTGDVVGGGTDSNIFMTLYGINGSTEEMQLDKKKARFEREQNDTFIMEILDIAPFTK 1759
Query: 61 MRIRIDGLGSRPEWFLERILLKNMNTGDLTMFYYGDWLSQRKGKKTLVCEMCAVIDEEEM 120
MRIRIDGLGSRPEWFLERILLKNMNTGDLTMFYYGDWLSQRKGKKTLVCEMCAVIDEEEM
Sbjct: 1760 MRIRIDGLGSRPEWFLERILLKNMNTGDLTMFYYGDWLSQRKGKKTLVCEMCAVIDEEEM 1819
Query: 121 MEWTSYTVAVKTSDILGAGTDANVFIIIFGENGDSGTLALKQSANWNKFERNNTDTFNFP 180
MEWTSYTVAVKTSDILGAGTDANVFIIIFGENGDSGTLALKQSANWNKFERNNTDTFNFP
Sbjct: 1820 MEWTSYTVAVKTSDILGAGTDANVFIIIFGENGDSGTLALKQSANWNKFERNNTDTFNFP 1879
Query: 181 DMLSLGHLCKLRVWHDNKGIFPGWHLSYVDVKDNSRDETFHFQCDCWLSKSEGDGQTVRD 240
DMLSLGHLCKLRVWHDNKGIFPGWHLSYVDVKDNSRDETFHFQCDCWLSKSEGDGQTVRD
Sbjct: 1880 DMLSLGHLCKLRVWHDNKGIFPGWHLSYVDVKDNSRDETFHFQCDCWLSKSEGDGQTVRD 1939
Query: 241 FACANNKICDELEETTYEIVIETGNGGETRENVWLILEGRKNRSKEFLMENSSRQRAFRK 300
FACANNKICDELEETTYEIVIETGNGGETRENVWLILEGRKNRSKEFLMENSSRQRAFRK
Sbjct: 1940 FACANNKICDELEETTYEIVIETGNGGETRENVWLILEGRKNRSKEFLMENSSRQRAFRK 1999
Query: 301 GTTDTFEFDSIYLGDIASLCVGHLAREDRFIPKRELAWHVKTITITEMEYGNVYFFNCDC 360
GTTDTFEFDSIYLGDIASLCVGHLAREDRFIPKRELAWHVKTITITEMEYGNVYFFNCDC
Sbjct: 2000 GTTDTFEFDSIYLGDIASLCVGHLAREDRFIPKRELAWHVKTITITEMEYGNVYFFNCDC 2059
Query: 361 LIPLKRKRKYFKVFEVTKTTESFASKVQSLVPVKYEVIVTTGYEPGAGTDANVFVTIFGA 420
LIPLKRKRKYFKVFEVTKTTESFASKVQSLVPVKYEVIVTTGYEPGAGTDANVFVTIFGA
Sbjct: 2060 LIPLKRKRKYFKVFEVTKTTESFASKVQSLVPVKYEVIVTTGYEPGAGTDANVFVTIFGA 2119
Query: 421 NGDTGKRELKQKMRNLFERGSTDRFFLETLELGELRKVRLEHDSSGYCSGWLVEKVEVTN 480
NGDTGKRELKQKMRNLFERGSTDRFFLETLELGELRKVRLEHDSSGYCSGWLVEKVEVTN
Sbjct: 2120 NGDTGKRELKQKMRNLFERGSTDRFFLETLELGELRKVRLEHDSSGYCSGWLVEKVEVTN 2179
Query: 481 TSTGVATIFNCGRWLDKKRGDGLTWRDLFPSV 512
TSTGVATIFNCGRWLDKKRGDGLTWRDLFPSV
Sbjct: 2180 TSTGVATIFNCGRWLDKKRGDGLTWRDLFPSV 2211
Score = 254 bits (649), Expect = 1e-67
Identities = 181/551 (32%), Positives = 268/551 (48%), Gaps = 58/551 (10%)
Query: 3 VWTGDVVGGGTDSNIFMTLYGIN-GSTEEMQLDK--KKARFEREQNDTFIMEILDIAPFT 59
V TG+V GTD+N+++T+YG G T E L K K +FE+ Q DTF + +D+ T
Sbjct: 1028 VVTGNVPKAGTDANVYLTIYGEEYGDTGERPLKKSDKSNKFEQGQTDTFTIYAIDLGALT 1087
Query: 60 KMRIRIDGLGSRPEWFLERILLKNMNTGDLTMFYYGDWLSQRKGKKTLVCEMCAVIDE-- 117
K+RIR D G+R WFL+RI + +MN F WL+ + L E+ V +
Sbjct: 1088 KIRIRHDNTGNRAGWFLDRIDITDMNNEITYYFPCQRWLAVEEDDGQLSRELLPVDESYV 1147
Query: 118 ---------------------EEMMEWTSYTVAVKTSDILGAGTDANVFIIIFGENGDSG 156
E+ + T+++V +KT AGTDANVFI +FG D+G
Sbjct: 1148 LPQSEEGRGGGDNNPLDNLALEQKDKSTTFSVTIKTGVKKNAGTDANVFITLFGTQDDTG 1207
Query: 157 TLALKQS-ANWNKFERNNTDTFNFPDMLSLGHLCKLRVWHDNKGIFPGWHLSYVDVKDNS 215
LK S N +KFER++ + F + L LG L K+R+ HDN G PGW + +V+V S
Sbjct: 1208 MTLLKSSKTNSDKFERDSIEIFTV-ETLDLGDLWKVRLGHDNTGKAPGWFVDWVEVDAPS 1266
Query: 216 RDETFHFQCDCWLSKSEGDGQTVRDFACANNKICDELEETTYEIVIETGN--GGETRENV 273
+ F C WL+K+E DG +RD A + YEI + T + T N+
Sbjct: 1267 LGKCMTFPCGRWLAKNEDDGSIIRDLFHAELQTRLYTPFVPYEITLYTSDVFAAGTDANI 1326
Query: 274 WLILEGRKN--RSKEFLMENSSRQRAF-RKGTTDTFEFDSIYLGDIAS-LCVGHLAREDR 329
++I+ G +++L N Q+ F + + F + +G+I + +GH
Sbjct: 1327 FIIIYGCDAVCTQQKYLCTNKREQKQFFERKSASRFIVELEDVGEIIEKIRIGH--NNTG 1384
Query: 330 FIPKRELAWHVKTITITEM----EYGNVYFFNCDCLIPLKRKRKY-------FKVFEVTK 378
P WH + I + + F CD + K + +F
Sbjct: 1385 MNP----GWHCSHVDIRRLLPDKDGAETLTFPCDRWLATSEDDKKTIRELVPYDIFTEKY 1440
Query: 379 TTESFASKVQSLVP-----VKYEVIVTTGYEPGAGTDANVFVTIFGANGDTGKREL--KQ 431
+ +V V V Y V + TG PGAGTDA V++TI+G GDTG+R L +
Sbjct: 1441 MKDGSLRQVYKEVEEPLDIVLYSVQIFTGNIPGAGTDAKVYITIYGDLGDTGERYLGKSE 1500
Query: 432 KMRNLFERGSTDRFFLETLELGELRKVRLEHDSSGYCSGWLVEKVEVTNTSTGVATIFNC 491
N FERG+ D F +E +LG + K++L HD+S +C+ W VEKVE+ N + +F C
Sbjct: 1501 NRTNKFERGTADTFIIEAADLGVIYKIKLRHDNSKWCADWYVEKVEIWNDTNEDEFLFLC 1560
Query: 492 GRWLDKKRGDG 502
GRWL K+ DG
Sbjct: 1561 GRWLSLKKEDG 1571
Score = 218 bits (555), Expect = 1e-56
Identities = 155/513 (30%), Positives = 246/513 (47%), Gaps = 33/513 (6%)
Query: 5 TGDVVGGGTDSNIFMTLYGINGSTEEMQL-DKKKARFEREQNDTFIMEILDIAPFTKMRI 63
TGDV G GTD+N+F+TL+G NG + ++QL K K+ FE+ D F + ++ K+RI
Sbjct: 51 TGDVRGAGTDANVFITLFGENGLSPKLQLTSKSKSAFEKGNVDVFRVRTNNVGLIYKVRI 110
Query: 64 RIDGLGSRPEWFLERILLKNMNTGDLTMFYY-GDWLSQRKGKKTLVCEMCAVIDEEEMME 122
D G W+L+ +++ +M L ++ +WLS+ +G + ++ A + +M
Sbjct: 111 EHDNTGLNASWYLDHVIVTDMKRPHLRYYFNCNNWLSKVEGDRQWCRDLLASFNPMDMPR 170
Query: 123 WTSYTVAVKTSDILGAGTDANVFIIIFGENGDSGTLALKQSANWNKFERNNTDTFNFPDM 182
Y V V T D++GAGTDA+VFI IFGE GD+G L+ + FE+ D F D
Sbjct: 171 GNKYEVKVYTGDVIGAGTDADVFINIFGEYGDTGERRLENEK--DNFEKGAEDRF-ILDA 227
Query: 183 LSLGHLCKLRVWHDNKGIFPGWHLSYVDVKDNSRDETFHFQCDCWLSKSEGDGQTVRDFA 242
LG L K+ V H+NKG GW LS + ++D + F + WL+ E DG+ RD
Sbjct: 228 PDLGQLMKINVGHNNKGGSAGWFLSQIVIEDIGNKRKYDFPLNRWLALDEDDGKIQRDIL 287
Query: 243 CANNKICDELEETTYEIVIETGN--GGETRENVWLIL---EGRKNRSKEFLMENSSRQRA 297
E TY + + TG+ G T+ ++L++ G KN K FL
Sbjct: 288 VGG----AETTAITYIVTVFTGDVRGAGTKSKIYLVMYGARGNKNSGKIFL-----EGGV 338
Query: 298 FRKGTTDTFEFD-SIYLGDIASLCVGH-LAREDRFIPKRELAWHVKTITITEMEYGNVYF 355
F +G TD F + ++ L ++ + VGH +R W + + I G
Sbjct: 339 FDRGRTDIFHIELAVLLSPLSRVSVGHGNVGVNR-------GWFCEKVVILCPFTGIQQT 391
Query: 356 FNCDCLIPLKRKRKYFKVFEVTKTTESFASKVQSLVPVKYEVIVTTGYEPGAGTDANVFV 415
F C + K+ + + E + + + L + + V T AGT++ +F+
Sbjct: 392 FPCSNWLDEKKADGLIE----RQLYEMVSLRKKRLKKFPWSLWVWTTDLKKAGTNSPIFI 447
Query: 416 TIFGANGDTGKRELKQKMRNLFERGSTDRFFLETLELGELRKVRLEHDSSGYCSGWLVEK 475
I+G G T + L F+ G ++F +E +LG K+R+ HD SGW +E+
Sbjct: 448 QIYGQKGRTDEILLNPN-NKWFKPGIIEKFRIELPDLGRFYKIRVWHDKRSSGSGWHLER 506
Query: 476 VEVTNTSTGVATIFNCGRWLDKKRGDGLTWRDL 508
+ + NT FNC RWLD D R++
Sbjct: 507 MTLMNTLNKDKYNFNCNRWLDANEDDNEIVREM 539
Score = 214 bits (545), Expect = 1e-55
Identities = 142/522 (27%), Positives = 252/522 (48%), Gaps = 27/522 (5%)
Query: 1 MTVWTGDVVGGGTDSNIFMTLYGINGSTEEMQLDKKKARFEREQNDTFIMEI-LDIAPFT 59
+TV+TGDV G GT S I++ +YG G+ ++ + F+R + D F +E+ + ++P +
Sbjct: 300 VTVFTGDVRGAGTKSKIYLVMYGARGNKNSGKIFLEGGVFDRGRTDIFHIELAVLLSPLS 359
Query: 60 KMRIRIDGLGSRPEWFLERILLKNMNTGDLTMFYYGDWLSQRKGKKTLVCEMCAVID-EE 118
++ + +G WF E++++ TG F +WL ++K + ++ ++ +
Sbjct: 360 RVSVGHGNVGVNRGWFCEKVVILCPFTGIQQTFPCSNWLDEKKADGLIERQLYEMVSLRK 419
Query: 119 EMMEWTSYTVAVKTSDILGAGTDANVFIIIFGENGDSGTLALKQSANWNKFERNNTDTFN 178
+ ++ +++ V T+D+ AGT++ +FI I+G+ G + + L + W K
Sbjct: 420 KRLKKFPWSLWVWTTDLKKAGTNSPIFIQIYGQKGRTDEILLNPNNKWFKPGIIEKFRIE 479
Query: 179 FPDMLSLGHLCKLRVWHDNKGIFPGWHLSYVDVKDNSRDETFHFQCDCWLSKSEGDGQTV 238
PD LG K+RVWHD + GWHL + + + + ++F C+ WL +E D + V
Sbjct: 480 LPD---LGRFYKIRVWHDKRSSGSGWHLERMTLMNTLNKDKYNFNCNRWLDANEDDNEIV 536
Query: 239 RDFACANNKICDELEETTYEIVIETGN--GGETRENVWLILEGRKNRSKEFLMENSSRQR 296
R+ + + Y + + TG G T NV+L L G + E L+ N
Sbjct: 537 REMTAEGPTVRRIMGMARYHVTVCTGELEGAGTDANVYLCLFGDVGDTGERLLYNCRNNT 596
Query: 297 -AFRKGTTDTFEFDSIYLGDIASLCVGHLAREDRFIPKRELAWHVKTITITEM---EYGN 352
F KG D F +S+ + ++ + + H + W++ + + E E N
Sbjct: 597 DLFEKGNADEFTIESVTMRNVRRVRIRHDGKGSGS------GWYLDRVLVREEGQPESDN 650
Query: 353 VYFFNCDCLIPLKRKRKYFKVFEVTKTTESFASKVQSLVPVKYEVIVTTGYEPGAGTDAN 412
V F CL L + + ++ ++S A+ L +Y + + TG GA TD+
Sbjct: 651 VEF---PCLRWLDKDKDDGQLVRELLPSDSSAT----LKNFRYHISLKTGDVSGASTDSR 703
Query: 413 VFVTIFGANGDTGKRELKQKMRNL---FERGSTDRFFLETLELGELRKVRLEHDSSGYCS 469
V++ ++G DT K+ L NL FERG D F LETL +G + ++ + HDS+G +
Sbjct: 704 VYIKLYGDKSDTIKQVLLVSDNNLKDYFERGRVDEFTLETLNIGNINRLVIGHDSTGMHA 763
Query: 470 GWLVEKVEVTNTSTGVATIFNCGRWLDKKRGDGLTWRDLFPS 511
W + V++ G F RWLDK + DG +L+PS
Sbjct: 764 SWFLGSVQIRVPRQGKQYTFPANRWLDKNQADGRLEVELYPS 805
Score = 211 bits (538), Expect = 1e-54
Identities = 145/518 (27%), Positives = 251/518 (48%), Gaps = 29/518 (5%)
Query: 3 VWTGDVVGGGTDSNIFMTLYGINGSTEEMQLDKKKARFEREQNDTFIMEILDIAPFTKMR 62
V+TGDV+G GTD+++F+ ++G G T E +L+ +K FE+ D FI++ D+ K+
Sbjct: 178 VYTGDVIGAGTDADVFINIFGEYGDTGERRLENEKDNFEKGAEDRFILDAPDLGQLMKIN 237
Query: 63 IRIDGLGSRPEWFLERILLKNMNTGDLTMFYYGDWLSQRKGKKTLVCEMCAVIDEEEMME 122
+ + G WFL +I+++++ F WL+ + + ++ E +
Sbjct: 238 VGHNNKGGSAGWFLSQIVIEDIGNKRKYDFPLNRWLALDEDDGKIQRDILVGGAETTAI- 296
Query: 123 WTSYTVAVKTSDILGAGTDANVFIIIFGENG--DSGTLALKQSANWNKFERNNTDTFNFP 180
+Y V V T D+ GAGT + ++++++G G +SG + L+ F+R TD F+
Sbjct: 297 --TYIVTVFTGDVRGAGTKSKIYLVMYGARGNKNSGKIFLEGGV----FDRGRTDIFHIE 350
Query: 181 DMLSLGHLCKLRVWHDNKGIFPGWHLSYVDVKDNSRDETFHFQCDCWLSKSEGDGQTVRD 240
+ L L ++ V H N G+ GW V + F C WL + + DG R
Sbjct: 351 LAVLLSPLSRVSVGHGNVGVNRGWFCEKVVILCPFTGIQQTFPCSNWLDEKKADGLIERQ 410
Query: 241 FACANNKICDELEETTYEIVIETGN--GGETRENVWLILEGRKNRSKEFLMENSSRQRAF 298
+ L++ + + + T + T +++ + G+K R+ E L+ +++ F
Sbjct: 411 LYEMVSLRKKRLKKFPWSLWVWTTDLKKAGTNSPIFIQIYGQKGRTDEILLNPNNKW--F 468
Query: 299 RKGTTDTFEFDSIYLGDIASLCVGHLAREDRFIPKRELAWHVKTITITEMEYGNVYFFNC 358
+ G + F + LG + V H R WH++ +T+ + Y FNC
Sbjct: 469 KPGIIEKFRIELPDLGRFYKIRVWHDKRSS------GSGWHLERMTLMNTLNKDKYNFNC 522
Query: 359 DCLIPLKRKRKYFKVFEVTKTTESFASKVQSLVPV-KYEVIVTTGYEPGAGTDANVFVTI 417
+ + E+ + + V+ ++ + +Y V V TG GAGTDANV++ +
Sbjct: 523 NRWLDANEDDN-----EIVREMTAEGPTVRRIMGMARYHVTVCTGELEGAGTDANVYLCL 577
Query: 418 FGANGDTGKRELKQKMRN--LFERGSTDRFFLETLELGELRKVRLEHDSSGYCSGWLVEK 475
FG GDTG+R L N LFE+G+ D F +E++ + +R+VR+ HD G SGW +++
Sbjct: 578 FGDVGDTGERLLYNCRNNTDLFEKGNADEFTIESVTMRNVRRVRIRHDGKGSGSGWYLDR 637
Query: 476 VEVTNTSTGVA--TIFNCGRWLDKKRGDGLTWRDLFPS 511
V V + F C RWLDK + DG R+L PS
Sbjct: 638 VLVREEGQPESDNVEFPCLRWLDKDKDDGQLVRELLPS 675
Score = 209 bits (533), Expect = 4e-54
Identities = 149/483 (30%), Positives = 241/483 (49%), Gaps = 26/483 (5%)
Query: 3 VWTGDVVGGGTDSNIFMTLYGINGSTEEMQLDKKKARFEREQNDTFIMEILDIAPFTKMR 62
VWT D+ GT+S IF+ +YG G T+E+ L+ F+ + F +E+ D+ F K+R
Sbjct: 431 VWTTDLKKAGTNSPIFIQIYGQKGRTDEILLNPNNKWFKPGIIEKFRIELPDLGRFYKIR 490
Query: 63 IRIDGLGSRPEWFLERILLKNMNTGDLTMFYYGDWLSQRKGKKTLVCEMCAVIDE-EEMM 121
+ D S W LER+ L N D F WL + +V EM A +M
Sbjct: 491 VWHDKRSSGSGWHLERMTLMNTLNKDKYNFNCNRWLDANEDDNEIVREMTAEGPTVRRIM 550
Query: 122 EWTSYTVAVKTSDILGAGTDANVFIIIFGENGDSGTLALKQSAN-WNKFERNNTDTFNFP 180
Y V V T ++ GAGTDANV++ +FG+ GD+G L N + FE+ N D F
Sbjct: 551 GMARYHVTVCTGELEGAGTDANVYLCLFGDVGDTGERLLYNCRNNTDLFEKGNADEFTI- 609
Query: 181 DMLSLGHLCKLRVWHDNKGIFPGWHLSYVDVKDNSRDET--FHFQCDCWLSKSEGDGQTV 238
+ +++ ++ ++R+ HD KG GW+L V V++ + E+ F C WL K + DGQ V
Sbjct: 610 ESVTMRNVRRVRIRHDGKGSGSGWYLDRVLVREEGQPESDNVEFPCLRWLDKDKDDGQLV 669
Query: 239 RDFACANNKICDELEETTYEIVIETGN--GGETRENVWLILEGRKNRS--KEFLMENSSR 294
R+ +++ L+ Y I ++TG+ G T V++ L G K+ + + L+ +++
Sbjct: 670 RELLPSDSSAT--LKNFRYHISLKTGDVSGASTDSRVYIKLYGDKSDTIKQVLLVSDNNL 727
Query: 295 QRAFRKGTTDTFEFDSIYLGDIASLCVGHLAREDRFIPKRELAWHVKTITITEMEYGNVY 354
+ F +G D F +++ +G+I L +GH + +W + ++ I G Y
Sbjct: 728 KDYFERGRVDEFTLETLNIGNINRLVIGHDSTG------MHASWFLGSVQIRVPRQGKQY 781
Query: 355 FFNCDCLIPLKRKRKYFKVFEVTKTTESFASKVQSLVP-VKYEVIVTTGYEPGAGTDANV 413
F + + + +V E + S+V + V YEV + TG GAGT A V
Sbjct: 782 TFPANRWLDKNQADGRLEV-------ELYPSEVVEIQKLVHYEVEIWTGDVGGAGTSARV 834
Query: 414 FVTIFGANGDTGKRELKQKMRNLFERGSTDRFFLETLELGELRKVRLEHDSSGYCSGWLV 473
++ I+G G T L + + +FER S D F LE ++GE+ K+RL H G+ W V
Sbjct: 835 YMQIYGEKGKTEVLFLSSRSK-VFERASKDTFQLEAADVGEVYKLRLGHTGEGFGPSWFV 893
Query: 474 EKV 476
+ V
Sbjct: 894 DTV 896
Score = 180 bits (457), Expect = 2e-45
Identities = 141/528 (26%), Positives = 241/528 (45%), Gaps = 72/528 (13%)
Query: 1 MTVWTGDVVGGGTDSNIFMTLYGINGSTEEMQLDKKKA---RFEREQNDTFIMEILDIAP 57
+T+ TG GTD+N+F+TL+G T L K +FER+ + F +E LD+
Sbjct: 1179 VTIKTGVKKNAGTDANVFITLFGTQDDTGMTLLKSSKTNSDKFERDSIEIFTVETLDLGD 1238
Query: 58 FTKMRIRIDGLGSRPEWFLERILLKNMNTGDLTMFYYGDWLSQRKGKKTLVCEMC-AVID 116
K+R+ D G P WF++ + + + G F G WL++ + +++ ++ A +
Sbjct: 1239 LWKVRLGHDNTGKAPGWFVDWVEVDAPSLGKCMTFPCGRWLAKNEDDGSIIRDLFHAELQ 1298
Query: 117 EEEMMEWTSYTVAVKTSDILGAGTDANVFIIIFGENG---DSGTLALKQSANWNKFERNN 173
+ Y + + TSD+ AGTDAN+FIII+G + L + FER +
Sbjct: 1299 TRLYTPFVPYEITLYTSDVFAAGTDANIFIIIYGCDAVCTQQKYLCTNKREQKQFFERKS 1358
Query: 174 TDTFNFPDMLSLGHLC-KLRVWHDNKGIFPGWHLSYVDVK----DNSRDETFHFQCDCWL 228
F ++ +G + K+R+ H+N G+ PGWH S+VD++ D ET F CD WL
Sbjct: 1359 ASRF-IVELEDVGEIIEKIRIGHNNTGMNPGWHCSHVDIRRLLPDKDGAETLTFPCDRWL 1417
Query: 229 SKSEGDGQTVRDFACAN------------NKICDELEE----TTYEIVIETGN--GGETR 270
+ SE D +T+R+ + ++ E+EE Y + I TGN G T
Sbjct: 1418 ATSEDDKKTIRELVPYDIFTEKYMKDGSLRQVYKEVEEPLDIVLYSVQIFTGNIPGAGTD 1477
Query: 271 ENVWLILEGRKNRSKE-FLMENSSRQRAFRKGTTDTFEFDSIYLGDIASLCVGHLAREDR 329
V++ + G + E +L ++ +R F +GT DTF ++ LG I + + H D
Sbjct: 1478 AKVYITIYGDLGDTGERYLGKSENRTNKFERGTADTFIIEAADLGVIYKIKLRH----DN 1533
Query: 330 FIPKRELAWHVKTITITEMEYGNVYFFNCDCLIPLKR-----KRKYFKV----------- 373
K W+V+ + I + + F C + LK+ +R +++
Sbjct: 1534 --SKWCADWYVEKVEIWNDTNEDEFLFLCGRWLSLKKEDGRLERLFYEKEYTGDRSSNCS 1591
Query: 374 ----------------FEVTKTTESFASKVQSLVPVKYEVIVTTGYEPGAGTDANVFVTI 417
+++ T A VQ + Y V VTTG A TD+ F+ +
Sbjct: 1592 SPADFWEIALSSKMADVDISTVTGPMADYVQEGPIIPYYVSVTTGKHKDAATDSRAFIFL 1651
Query: 418 FGANGDTGKRELKQKMRNL--FERGSTDRFFLETLELGELRKVRLEHD 463
G + + KR R F RGS + F++ L++G ++K+ + ++
Sbjct: 1652 IGEDDERSKRIWLDYPRGKRGFSRGSVEEFYVAGLDVGIIKKIEVLYE 1699
Score = 180 bits (456), Expect = 3e-45
Identities = 129/400 (32%), Positives = 192/400 (48%), Gaps = 24/400 (6%)
Query: 117 EEEMMEWTSYTVAVKTSDILGAGTDANVFIIIFGENGDSGTLALKQSANWNKFERNNTDT 176
E E + Y V T D+ GAGTDANVFI +FGENG S L L + + FE+ N D
Sbjct: 36 EHEYYKARVYEVVTATGDVRGAGTDANVFITLFGENGLSPKLQLTSKSK-SAFEKGNVDV 94
Query: 177 FNFPDMLSLGHLCKLRVWHDNKGIFPGWHLSYVDVKDNSRDET-FHFQCDCWLSKSEGDG 235
F ++G + K+R+ HDN G+ W+L +V V D R ++F C+ WLSK EGD
Sbjct: 95 FRVRTN-NVGLIYKVRIEHDNTGLNASWYLDHVIVTDMKRPHLRYYFNCNNWLSKVEGDR 153
Query: 236 QTVRDFACANNKICDELEETTYEIVIETGN--GGETRENVWLILEGRKNRSKEFLMENSS 293
Q RD + N + D YE+ + TG+ G T +V++ + G + E +EN
Sbjct: 154 QWCRDLLASFNPM-DMPRGNKYEVKVYTGDVIGAGTDADVFINIFGEYGDTGERRLENEK 212
Query: 294 RQRAFRKGTTDTFEFDSIYLGDIASLCVGHLAREDRFIPKRELAWHVKTITITEMEYGNV 353
F KG D F D+ LG + + VGH + W + I I ++
Sbjct: 213 DN--FEKGAEDRFILDAPDLGQLMKINVGHNNKGG------SAGWFLSQIVIEDIGNKRK 264
Query: 354 YFFNCDCLIPLKRKRKYFKVFEVTKTTESFASKVQSLVPVKYEVIVTTGYEPGAGTDANV 413
Y F + + L + + E+ A + Y V V TG GAGT + +
Sbjct: 265 YDFPLNRWLALDEDDGKIQRDILVGGAETTA--------ITYIVTVFTGDVRGAGTKSKI 316
Query: 414 FVTIFGANGDTGKRELKQKMRNLFERGSTDRFFLE-TLELGELRKVRLEHDSSGYCSGWL 472
++ ++GA G+ ++ + +F+RG TD F +E + L L +V + H + G GW
Sbjct: 317 YLVMYGARGNKNSGKIFLE-GGVFDRGRTDIFHIELAVLLSPLSRVSVGHGNVGVNRGWF 375
Query: 473 VEKVEVTNTSTGVATIFNCGRWLDKKRGDGLTWRDLFPSV 512
EKV + TG+ F C WLD+K+ DGL R L+ V
Sbjct: 376 CEKVVILCPFTGIQQTFPCSNWLDEKKADGLIERQLYEMV 415
Score = 172 bits (436), Expect = 7e-43
Identities = 141/459 (30%), Positives = 212/459 (46%), Gaps = 68/459 (14%)
Query: 97 WLSQRKGKKTLVCEMCAVIDEEEMMEWTSYTVAVKTSDILGAGTDANVFIIIFGEN-GDS 155
WL++ K LV E+ V + E +Y V V T ++ AGTDANV++ I+GE GD+
Sbjct: 997 WLARGKEDNELVVEL--VPAGKPGPERNTYEVQVVTGNVPKAGTDANVYLTIYGEEYGDT 1054
Query: 156 GTLALKQSANWNKFERNNTDTFNFPDMLSLGHLCKLRVWHDNKGIFPGWHLSYVDVKDNS 215
G LK+S NKFE+ TDTF + LG L K+R+ HDN G GW L +D+ D +
Sbjct: 1055 GERPLKKSDKSNKFEQGQTDTFTI-YAIDLGALTKIRIRHDNTGNRAGWFLDRIDITDMN 1113
Query: 216 RDETFHFQCDCWLSKSEGDGQTVRDF----------------ACANNKICDEL------E 253
+ T++F C WL+ E DGQ R+ +N D L +
Sbjct: 1114 NEITYYFPCQRWLAVEEDDGQLSRELLPVDESYVLPQSEEGRGGGDNNPLDNLALEQKDK 1173
Query: 254 ETTYEIVIETG---NGGETRENVWLILEGRKNRSKEFLMENS-SRQRAFRKGTTDTFEFD 309
TT+ + I+TG N G T NV++ L G ++ + L+++S + F + + + F +
Sbjct: 1174 STTFSVTIKTGVKKNAG-TDANVFITLFGTQDDTGMTLLKSSKTNSDKFERDSIEIFTVE 1232
Query: 310 SIYLGDIASLCVGHLAREDRFIPKRELAWHVKTITITEMEYGNVYFFNCDCLIPLKRK-- 367
++ LGD+ + +GH D + W V + + G F C +
Sbjct: 1233 TLDLGDLWKVRLGH----DN--TGKAPGWFVDWVEVDAPSLGKCMTFPCGRWLAKNEDDG 1286
Query: 368 ---RKYFKVFEVTKTTESFASKVQSLVPVKYEVIVTTGYEPGAGTDANVFVTIFGANG-- 422
R F T+ F V YE+ + T AGTDAN+F+ I+G +
Sbjct: 1287 SIIRDLFHAELQTRLYTPF---------VPYEITLYTSDVFAAGTDANIFIIIYGCDAVC 1337
Query: 423 ------DTGKRELKQKMRNLFERGSTDRFFLETLELGE-LRKVRLEHDSSGYCSGWLVEK 475
T KRE KQ FER S RF +E ++GE + K+R+ H+++G GW
Sbjct: 1338 TQQKYLCTNKREQKQ----FFERKSASRFIVELEDVGEIIEKIRIGHNNTGMNPGWHCSH 1393
Query: 476 VEVTN---TSTGVATI-FNCGRWLDKKRGDGLTWRDLFP 510
V++ G T+ F C RWL D T R+L P
Sbjct: 1394 VDIRRLLPDKDGAETLTFPCDRWLATSEDDKKTIRELVP 1432
Score = 127 bits (318), Expect = 3e-29
Identities = 101/391 (25%), Positives = 175/391 (44%), Gaps = 40/391 (10%)
Query: 126 YTVAVKTSDILGAGTDANVFIIIFGENGDSGTLALKQSANWNKFERNNTDTFNFPDMLSL 185
Y + V T D++G GTD+N+F+ ++G NG + + L + +FER DTF ++L +
Sbjct: 1698 YEMTVWTGDVVGGGTDSNIFMTLYGINGSTEEMQLDKKK--ARFEREQNDTF-IMEILDI 1754
Query: 186 GHLCKLRVWHDNKGIFPGWHLSYVDVKDNSRDETFHFQCDCWLSKSEGDGQTVRDFACAN 245
K+R+ D G P W L + +K+ + + F WLS+ +G + C
Sbjct: 1755 APFTKMRIRIDGLGSRPEWFLERILLKNMNTGDLTMFYYGDWLSQRKGK----KTLVCEM 1810
Query: 246 NKICDE---LEETTYEIVIETGN--GGETRENVWLILEGRKNRSKEFLMENSSRQRAFRK 300
+ DE +E T+Y + ++T + G T NV++I+ G S ++ S+ F +
Sbjct: 1811 CAVIDEEEMMEWTSYTVAVKTSDILGAGTDANVFIIIFGENGDSGTLALKQSANWNKFER 1870
Query: 301 GTTDTFEF-DSIYLGDIASLCVGHLAREDRFIPKRELAWHVKTITITEMEYGNVYFFNCD 359
TDTF F D + LG + L V H P WH+ + + + + F CD
Sbjct: 1871 NNTDTFNFPDMLSLGHLCKLRVWH--DNKGIFP----GWHLSYVDVKDNSRDETFHFQCD 1924
Query: 360 CLIPLKRKRKYFKVFEVTKTTESFA---SKV-QSLVPVKYEVIVTTGYEPGAGTDANVFV 415
C + K +T FA +K+ L YE+++ TG G T NV++
Sbjct: 1925 CWLS--------KSEGDGQTVRDFACANNKICDELEETTYEIVIETG--NGGETRENVWL 1974
Query: 416 TIFGANGDTGKRELKQKMR-NLFERGSTDRFFLETLELGELRKVRLEHDS------SGYC 468
+ G + + ++ R F +G+TD F +++ LG++ + + H +
Sbjct: 1975 ILEGRKNRSKEFLMENSSRQRAFRKGTTDTFEFDSIYLGDIASLCVGHLAREDRFIPKRE 2034
Query: 469 SGWLVEKVEVTNTSTGVATIFNCGRWLDKKR 499
W V+ + +T G FNC + KR
Sbjct: 2035 LAWHVKTITITEMEYGNVYFFNCDCLIPLKR 2065
Score = 84.7 bits (208), Expect = 2e-16
Identities = 41/110 (37%), Positives = 66/110 (60%), Gaps = 1/110 (0%)
Query: 391 VPVKYEVIVTTGYEPGAGTDANVFVTIFGANGDTGKRELKQKMRNLFERGSTDRFFLETL 450
+ V YE+ V TG G GTD+N+F+T++G NG T + +L +K + FER D F +E L
Sbjct: 1694 IEVLYEMTVWTGDVVGGGTDSNIFMTLYGINGSTEEMQLDKK-KARFEREQNDTFIMEIL 1752
Query: 451 ELGELRKVRLEHDSSGYCSGWLVEKVEVTNTSTGVATIFNCGRWLDKKRG 500
++ K+R+ D G W +E++ + N +TG T+F G WL +++G
Sbjct: 1753 DIAPFTKMRIRIDGLGSRPEWFLERILLKNMNTGDLTMFYYGDWLSQRKG 1802
Score = 72.0 bits (175), Expect = 1e-12
Identities = 31/82 (37%), Positives = 48/82 (58%)
Query: 3 VWTGDVVGGGTDSNIFMTLYGINGSTEEMQLDKKKARFEREQNDTFIMEILDIAPFTKMR 62
+WTGDV G GT + ++M +YG G TE + L + FER DTF +E D+ K+R
Sbjct: 820 IWTGDVGGAGTSARVYMQIYGEKGKTEVLFLSSRSKVFERASKDTFQLEAADVGEVYKLR 879
Query: 63 IRIDGLGSRPEWFLERILLKNM 84
+ G G P WF++ + L+++
Sbjct: 880 LGHTGEGFGPSWFVDTVWLRHL 901
>gi|224458290 lipoxygenase homology domains 1 isoform 3 [Homo
sapiens]
Length = 512
Score = 1060 bits (2741), Expect = 0.0
Identities = 512/512 (100%), Positives = 512/512 (100%)
Query: 1 MTVWTGDVVGGGTDSNIFMTLYGINGSTEEMQLDKKKARFEREQNDTFIMEILDIAPFTK 60
MTVWTGDVVGGGTDSNIFMTLYGINGSTEEMQLDKKKARFEREQNDTFIMEILDIAPFTK
Sbjct: 1 MTVWTGDVVGGGTDSNIFMTLYGINGSTEEMQLDKKKARFEREQNDTFIMEILDIAPFTK 60
Query: 61 MRIRIDGLGSRPEWFLERILLKNMNTGDLTMFYYGDWLSQRKGKKTLVCEMCAVIDEEEM 120
MRIRIDGLGSRPEWFLERILLKNMNTGDLTMFYYGDWLSQRKGKKTLVCEMCAVIDEEEM
Sbjct: 61 MRIRIDGLGSRPEWFLERILLKNMNTGDLTMFYYGDWLSQRKGKKTLVCEMCAVIDEEEM 120
Query: 121 MEWTSYTVAVKTSDILGAGTDANVFIIIFGENGDSGTLALKQSANWNKFERNNTDTFNFP 180
MEWTSYTVAVKTSDILGAGTDANVFIIIFGENGDSGTLALKQSANWNKFERNNTDTFNFP
Sbjct: 121 MEWTSYTVAVKTSDILGAGTDANVFIIIFGENGDSGTLALKQSANWNKFERNNTDTFNFP 180
Query: 181 DMLSLGHLCKLRVWHDNKGIFPGWHLSYVDVKDNSRDETFHFQCDCWLSKSEGDGQTVRD 240
DMLSLGHLCKLRVWHDNKGIFPGWHLSYVDVKDNSRDETFHFQCDCWLSKSEGDGQTVRD
Sbjct: 181 DMLSLGHLCKLRVWHDNKGIFPGWHLSYVDVKDNSRDETFHFQCDCWLSKSEGDGQTVRD 240
Query: 241 FACANNKICDELEETTYEIVIETGNGGETRENVWLILEGRKNRSKEFLMENSSRQRAFRK 300
FACANNKICDELEETTYEIVIETGNGGETRENVWLILEGRKNRSKEFLMENSSRQRAFRK
Sbjct: 241 FACANNKICDELEETTYEIVIETGNGGETRENVWLILEGRKNRSKEFLMENSSRQRAFRK 300
Query: 301 GTTDTFEFDSIYLGDIASLCVGHLAREDRFIPKRELAWHVKTITITEMEYGNVYFFNCDC 360
GTTDTFEFDSIYLGDIASLCVGHLAREDRFIPKRELAWHVKTITITEMEYGNVYFFNCDC
Sbjct: 301 GTTDTFEFDSIYLGDIASLCVGHLAREDRFIPKRELAWHVKTITITEMEYGNVYFFNCDC 360
Query: 361 LIPLKRKRKYFKVFEVTKTTESFASKVQSLVPVKYEVIVTTGYEPGAGTDANVFVTIFGA 420
LIPLKRKRKYFKVFEVTKTTESFASKVQSLVPVKYEVIVTTGYEPGAGTDANVFVTIFGA
Sbjct: 361 LIPLKRKRKYFKVFEVTKTTESFASKVQSLVPVKYEVIVTTGYEPGAGTDANVFVTIFGA 420
Query: 421 NGDTGKRELKQKMRNLFERGSTDRFFLETLELGELRKVRLEHDSSGYCSGWLVEKVEVTN 480
NGDTGKRELKQKMRNLFERGSTDRFFLETLELGELRKVRLEHDSSGYCSGWLVEKVEVTN
Sbjct: 421 NGDTGKRELKQKMRNLFERGSTDRFFLETLELGELRKVRLEHDSSGYCSGWLVEKVEVTN 480
Query: 481 TSTGVATIFNCGRWLDKKRGDGLTWRDLFPSV 512
TSTGVATIFNCGRWLDKKRGDGLTWRDLFPSV
Sbjct: 481 TSTGVATIFNCGRWLDKKRGDGLTWRDLFPSV 512
>gi|224458288 lipoxygenase homology domains 1 isoform 2 [Homo sapiens]
Length = 1114
Score = 933 bits (2412), Expect = 0.0
Identities = 452/452 (100%), Positives = 452/452 (100%)
Query: 1 MTVWTGDVVGGGTDSNIFMTLYGINGSTEEMQLDKKKARFEREQNDTFIMEILDIAPFTK 60
MTVWTGDVVGGGTDSNIFMTLYGINGSTEEMQLDKKKARFEREQNDTFIMEILDIAPFTK
Sbjct: 651 MTVWTGDVVGGGTDSNIFMTLYGINGSTEEMQLDKKKARFEREQNDTFIMEILDIAPFTK 710
Query: 61 MRIRIDGLGSRPEWFLERILLKNMNTGDLTMFYYGDWLSQRKGKKTLVCEMCAVIDEEEM 120
MRIRIDGLGSRPEWFLERILLKNMNTGDLTMFYYGDWLSQRKGKKTLVCEMCAVIDEEEM
Sbjct: 711 MRIRIDGLGSRPEWFLERILLKNMNTGDLTMFYYGDWLSQRKGKKTLVCEMCAVIDEEEM 770
Query: 121 MEWTSYTVAVKTSDILGAGTDANVFIIIFGENGDSGTLALKQSANWNKFERNNTDTFNFP 180
MEWTSYTVAVKTSDILGAGTDANVFIIIFGENGDSGTLALKQSANWNKFERNNTDTFNFP
Sbjct: 771 MEWTSYTVAVKTSDILGAGTDANVFIIIFGENGDSGTLALKQSANWNKFERNNTDTFNFP 830
Query: 181 DMLSLGHLCKLRVWHDNKGIFPGWHLSYVDVKDNSRDETFHFQCDCWLSKSEGDGQTVRD 240
DMLSLGHLCKLRVWHDNKGIFPGWHLSYVDVKDNSRDETFHFQCDCWLSKSEGDGQTVRD
Sbjct: 831 DMLSLGHLCKLRVWHDNKGIFPGWHLSYVDVKDNSRDETFHFQCDCWLSKSEGDGQTVRD 890
Query: 241 FACANNKICDELEETTYEIVIETGNGGETRENVWLILEGRKNRSKEFLMENSSRQRAFRK 300
FACANNKICDELEETTYEIVIETGNGGETRENVWLILEGRKNRSKEFLMENSSRQRAFRK
Sbjct: 891 FACANNKICDELEETTYEIVIETGNGGETRENVWLILEGRKNRSKEFLMENSSRQRAFRK 950
Query: 301 GTTDTFEFDSIYLGDIASLCVGHLAREDRFIPKRELAWHVKTITITEMEYGNVYFFNCDC 360
GTTDTFEFDSIYLGDIASLCVGHLAREDRFIPKRELAWHVKTITITEMEYGNVYFFNCDC
Sbjct: 951 GTTDTFEFDSIYLGDIASLCVGHLAREDRFIPKRELAWHVKTITITEMEYGNVYFFNCDC 1010
Query: 361 LIPLKRKRKYFKVFEVTKTTESFASKVQSLVPVKYEVIVTTGYEPGAGTDANVFVTIFGA 420
LIPLKRKRKYFKVFEVTKTTESFASKVQSLVPVKYEVIVTTGYEPGAGTDANVFVTIFGA
Sbjct: 1011 LIPLKRKRKYFKVFEVTKTTESFASKVQSLVPVKYEVIVTTGYEPGAGTDANVFVTIFGA 1070
Query: 421 NGDTGKRELKQKMRNLFERGSTDRFFLETLEL 452
NGDTGKRELKQKMRNLFERGSTDRFFLETLEL
Sbjct: 1071 NGDTGKRELKQKMRNLFERGSTDRFFLETLEL 1102
Score = 216 bits (550), Expect = 4e-56
Identities = 161/571 (28%), Positives = 265/571 (46%), Gaps = 72/571 (12%)
Query: 1 MTVWTGDVVGGGTDSNIFMTLYGINGSTEEMQLDKKKA---RFEREQNDTFIMEILDIAP 57
+T+ TG GTD+N+F+TL+G T L K +FER+ + F +E LD+
Sbjct: 68 VTIKTGVKKNAGTDANVFITLFGTQDDTGMTLLKSSKTNSDKFERDSIEIFTVETLDLGD 127
Query: 58 FTKMRIRIDGLGSRPEWFLERILLKNMNTGDLTMFYYGDWLSQRKGKKTLVCEMC-AVID 116
K+R+ D G P WF++ + + + G F G WL++ + +++ ++ A +
Sbjct: 128 LWKVRLGHDNTGKAPGWFVDWVEVDAPSLGKCMTFPCGRWLAKNEDDGSIIRDLFHAELQ 187
Query: 117 EEEMMEWTSYTVAVKTSDILGAGTDANVFIIIFGENG---DSGTLALKQSANWNKFERNN 173
+ Y + + TSD+ AGTDAN+FIII+G + L + FER +
Sbjct: 188 TRLYTPFVPYEITLYTSDVFAAGTDANIFIIIYGCDAVCTQQKYLCTNKREQKQFFERKS 247
Query: 174 TDTFNFPDMLSLGHLC-KLRVWHDNKGIFPGWHLSYVDVK----DNSRDETFHFQCDCWL 228
F ++ +G + K+R+ H+N G+ PGWH S+VD++ D ET F CD WL
Sbjct: 248 ASRF-IVELEDVGEIIEKIRIGHNNTGMNPGWHCSHVDIRRLLPDKDGAETLTFPCDRWL 306
Query: 229 SKSEGDGQTVRDFACAN------------NKICDELEE----TTYEIVIETGN--GGETR 270
+ SE D +T+R+ + ++ E+EE Y + I TGN G T
Sbjct: 307 ATSEDDKKTIRELVPYDIFTEKYMKDGSLRQVYKEVEEPLDIVLYSVQIFTGNIPGAGTD 366
Query: 271 ENVWLILEGRKNRSKE-FLMENSSRQRAFRKGTTDTFEFDSIYLGDIASLCVGHLAREDR 329
V++ + G + E +L ++ +R F +GT DTF ++ LG I + + H D
Sbjct: 367 AKVYITIYGDLGDTGERYLGKSENRTNKFERGTADTFIIEAADLGVIYKIKLRH----DN 422
Query: 330 FIPKRELAWHVKTITITEMEYGNVYFFNCDCLIPLKR-----KRKYFKV----------- 373
K W+V+ + I + + F C + LK+ +R +++
Sbjct: 423 --SKWCADWYVEKVEIWNDTNEDEFLFLCGRWLSLKKEDGRLERLFYEKEYTGDRSSNCS 480
Query: 374 ----------------FEVTKTTESFASKVQSLVPVKYEVIVTTGYEPGAGTDANVFVTI 417
+++ T A VQ + Y V VTTG A TD+ F+ +
Sbjct: 481 SPADFWEIALSSKMADVDISTVTGPMADYVQEGPIIPYYVSVTTGKHKDAATDSRAFIFL 540
Query: 418 FGANGDTGKRELKQKMRNL--FERGSTDRFFLETLELGELRKVRLEHDSSGYCSGWLVEK 475
G + + KR R F RGS + F++ L++G ++K+ L HD + S WLVE+
Sbjct: 541 IGEDDERSKRIWLDYPRGKRGFSRGSVEEFYVAGLDVGIIKKIELGHDGASPESCWLVEE 600
Query: 476 VEVTNTSTGVATIFNCGRWLDKKRGDGLTWR 506
+ + + G + NC WL K RGDG+T R
Sbjct: 601 LCLAVPTQGTKYMLNCNCWLAKDRGDGITSR 631
Score = 203 bits (517), Expect = 3e-52
Identities = 161/551 (29%), Positives = 253/551 (45%), Gaps = 61/551 (11%)
Query: 3 VWTGDVVGGGTDSNIFMTLYGINGSTEEMQLDKKKAR---FEREQNDTFIMEILDIAPFT 59
++TG++ G GTD+ +++T+YG G T E L K + R FER DTFI+E D+
Sbjct: 355 IFTGNIPGAGTDAKVYITIYGDLGDTGERYLGKSENRTNKFERGTADTFIIEAADLGVIY 414
Query: 60 KMRIRIDGLGSRPEWFLERILLKNMNTGDLTMFYYGDWLSQRK---------------GK 104
K+++R D +W++E++ + N D +F G WLS +K G
Sbjct: 415 KIKLRHDNSKWCADWYVEKVEIWNDTNEDEFLFLCGRWLSLKKEDGRLERLFYEKEYTGD 474
Query: 105 KTLVCEMCA----------------------VIDEEEMMEWTSYTVAVKTSDILGAGTDA 142
++ C A + D + Y V+V T A TD+
Sbjct: 475 RSSNCSSPADFWEIALSSKMADVDISTVTGPMADYVQEGPIIPYYVSVTTGKHKDAATDS 534
Query: 143 NVFIIIFGENGD-SGTLALKQSANWNKFERNNTDTFNFPDMLSLGHLCKLRVWHDNKGIF 201
FI + GE+ + S + L F R + + F + L +G + K+ + HD
Sbjct: 535 RAFIFLIGEDDERSKRIWLDYPRGKRGFSRGSVEEF-YVAGLDVGIIKKIELGHDGASPE 593
Query: 202 PGWHLSYVDVKDNSRDETFHFQCDCWLSKSEGDGQTVRDFACANNKICDELEETTYEIVI 261
W + + + ++ + C+CWL+K GDG T R F + + + + YE+ +
Sbjct: 594 SCWLVEELCLAVPTQGTKYMLNCNCWLAKDRGDGITSRVFDLLDAMVVNIGVKVLYEMTV 653
Query: 262 ETGN--GGETRENVWLILEGRKNRSKEFLMENSSRQRAFRKGTTDTFEFDSIYLGDIASL 319
TG+ GG T N+++ L G ++E M+ ++ F + DTF + + + +
Sbjct: 654 WTGDVVGGGTDSNIFMTLYGINGSTEE--MQLDKKKARFEREQNDTFIMEILDIAPFTKM 711
Query: 320 CVGHLAREDRFIPKRELAWHVKTITITEMEYGNV-YFFNCDCLIPLKRKRKYFKVFEVTK 378
+ R D + E W ++ I + M G++ F+ D L +RK K V E+
Sbjct: 712 RI----RIDGLGSRPE--WFLERILLKNMNTGDLTMFYYGDWLS--QRKGKKTLVCEMCA 763
Query: 379 TTESFASKVQSLVPVKYEVIVTTGYEPGAGTDANVFVTIFGANGDTGKRELKQKMR-NLF 437
+ + + + Y V V T GAGTDANVF+ IFG NGD+G LKQ N F
Sbjct: 764 VID----EEEMMEWTSYTVAVKTSDILGAGTDANVFIIIFGENGDSGTLALKQSANWNKF 819
Query: 438 ERGSTDRF-FLETLELGELRKVRLEHDSSGYCSGWLVEKVEVTNTSTGVATIFNCGRWLD 496
ER +TD F F + L LG L K+R+ HD+ G GW + V+V + S F C WL
Sbjct: 820 ERNNTDTFNFPDMLSLGHLCKLRVWHDNKGIFPGWHLSYVDVKDNSRDETFHFQCDCWLS 879
Query: 497 KKRGDGLTWRD 507
K GDG T RD
Sbjct: 880 KSEGDGQTVRD 890
Score = 197 bits (501), Expect = 2e-50
Identities = 136/410 (33%), Positives = 203/410 (49%), Gaps = 32/410 (7%)
Query: 118 EEMMEWTSYTVAVKTSDILGAGTDANVFIIIFGENGDSGTLALKQS-ANWNKFERNNTDT 176
E+ + T+++V +KT AGTDANVFI +FG D+G LK S N +KFER++ +
Sbjct: 58 EQKDKSTTFSVTIKTGVKKNAGTDANVFITLFGTQDDTGMTLLKSSKTNSDKFERDSIEI 117
Query: 177 FNFPDMLSLGHLCKLRVWHDNKGIFPGWHLSYVDVKDNSRDETFHFQCDCWLSKSEGDGQ 236
F + L LG L K+R+ HDN G PGW + +V+V S + F C WL+K+E DG
Sbjct: 118 FTV-ETLDLGDLWKVRLGHDNTGKAPGWFVDWVEVDAPSLGKCMTFPCGRWLAKNEDDGS 176
Query: 237 TVRDFACANNKICDELEETTYEIVIETGN--GGETRENVWLILEGRKN--RSKEFLMENS 292
+RD A + YEI + T + T N+++I+ G +++L N
Sbjct: 177 IIRDLFHAELQTRLYTPFVPYEITLYTSDVFAAGTDANIFIIIYGCDAVCTQQKYLCTNK 236
Query: 293 SRQRAF-RKGTTDTFEFDSIYLGDIAS-LCVGHLAREDRFIPKRELAWHVKTITITEM-- 348
Q+ F + + F + +G+I + +GH P WH + I +
Sbjct: 237 REQKQFFERKSASRFIVELEDVGEIIEKIRIGH--NNTGMNP----GWHCSHVDIRRLLP 290
Query: 349 --EYGNVYFFNCDCLIPLKRKRKY-------FKVFEVTKTTESFASKVQSLVP-----VK 394
+ F CD + K + +F + +V V V
Sbjct: 291 DKDGAETLTFPCDRWLATSEDDKKTIRELVPYDIFTEKYMKDGSLRQVYKEVEEPLDIVL 350
Query: 395 YEVIVTTGYEPGAGTDANVFVTIFGANGDTGKREL--KQKMRNLFERGSTDRFFLETLEL 452
Y V + TG PGAGTDA V++TI+G GDTG+R L + N FERG+ D F +E +L
Sbjct: 351 YSVQIFTGNIPGAGTDAKVYITIYGDLGDTGERYLGKSENRTNKFERGTADTFIIEAADL 410
Query: 453 GELRKVRLEHDSSGYCSGWLVEKVEVTNTSTGVATIFNCGRWLDKKRGDG 502
G + K++L HD+S +C+ W VEKVE+ N + +F CGRWL K+ DG
Sbjct: 411 GVIYKIKLRHDNSKWCADWYVEKVEIWNDTNEDEFLFLCGRWLSLKKEDG 460
Score = 146 bits (369), Expect = 4e-35
Identities = 128/521 (24%), Positives = 224/521 (42%), Gaps = 46/521 (8%)
Query: 1 MTVWTGDVVGGGTDSNIFMTLYGINGSTEE---MQLDKKKARFEREQNDTFIMEILDIAP 57
++V TG TDS F+ L G + + + + K F R + F + LD+
Sbjct: 520 VSVTTGKHKDAATDSRAFIFLIGEDDERSKRIWLDYPRGKRGFSRGSVEEFYVAGLDVGI 579
Query: 58 FTKMRIRIDGLGSRPEWFLERILLKNMNTGDLTMFYYGDWLSQRKGKKTLVCEMCAVIDE 117
K+ + DG W +E + L G M WL++ +G + + ++D
Sbjct: 580 IKKIELGHDGASPESCWLVEELCLAVPTQGTKYMLNCNCWLAKDRG-DGITSRVFDLLDA 638
Query: 118 EEMMEWTS--YTVAVKTSDILGAGTDANVFIIIFGENGDSGTLALKQSANWNKFERNNTD 175
+ Y + V T D++G GTD+N+F+ ++G NG + + L + +FER D
Sbjct: 639 MVVNIGVKVLYEMTVWTGDVVGGGTDSNIFMTLYGINGSTEEMQLDKKK--ARFEREQND 696
Query: 176 TFNFPDMLSLGHLCKLRVWHDNKGIFPGWHLSYVDVKDNSRDETFHFQCDCWLSKSEGDG 235
TF ++L + K+R+ D G P W L + +K+ + + F WLS+ +G
Sbjct: 697 TF-IMEILDIAPFTKMRIRIDGLGSRPEWFLERILLKNMNTGDLTMFYYGDWLSQRKGK- 754
Query: 236 QTVRDFACANNKICDE---LEETTYEIVIETGN--GGETRENVWLILEGRKNRSKEFLME 290
+ C + DE +E T+Y + ++T + G T NV++I+ G S ++
Sbjct: 755 ---KTLVCEMCAVIDEEEMMEWTSYTVAVKTSDILGAGTDANVFIIIFGENGDSGTLALK 811
Query: 291 NSSRQRAFRKGTTDTFEF-DSIYLGDIASLCVGHLAREDRFIPKRELAWHVKTITITEME 349
S+ F + TDTF F D + LG + L V H P WH+ + + +
Sbjct: 812 QSANWNKFERNNTDTFNFPDMLSLGHLCKLRVWH--DNKGIFP----GWHLSYVDVKDNS 865
Query: 350 YGNVYFFNCDCLIPLKRKRKYFKVFEVTKTTESFA---SKV-QSLVPVKYEVIVTTGYEP 405
+ F CDC + K +T FA +K+ L YE+++ TG
Sbjct: 866 RDETFHFQCDCWLS--------KSEGDGQTVRDFACANNKICDELEETTYEIVIETG--N 915
Query: 406 GAGTDANVFVTIFGANGDTGKRELKQKMR-NLFERGSTDRFFLETLELGELRKVRLEHDS 464
G T NV++ + G + + ++ R F +G+TD F +++ LG++ + + H +
Sbjct: 916 GGETRENVWLILEGRKNRSKEFLMENSSRQRAFRKGTTDTFEFDSIYLGDIASLCVGHLA 975
Query: 465 ------SGYCSGWLVEKVEVTNTSTGVATIFNCGRWLDKKR 499
W V+ + +T G FNC + KR
Sbjct: 976 REDRFIPKRELAWHVKTITITEMEYGNVYFFNCDCLIPLKR 1016
Score = 111 bits (278), Expect = 1e-24
Identities = 59/117 (50%), Positives = 71/117 (60%), Gaps = 2/117 (1%)
Query: 395 YEVIVTTGYEPGAGTDANVFVTIFGANGDTGKRELKQKMRNL--FERGSTDRFFLETLEL 452
+ V + TG + AGTDANVF+T+FG DTG LK N FER S + F +ETL+L
Sbjct: 66 FSVTIKTGVKKNAGTDANVFITLFGTQDDTGMTLLKSSKTNSDKFERDSIEIFTVETLDL 125
Query: 453 GELRKVRLEHDSSGYCSGWLVEKVEVTNTSTGVATIFNCGRWLDKKRGDGLTWRDLF 509
G+L KVRL HD++G GW V+ VEV S G F CGRWL K DG RDLF
Sbjct: 126 GDLWKVRLGHDNTGKAPGWFVDWVEVDAPSLGKCMTFPCGRWLAKNEDDGSIIRDLF 182
Score = 95.1 bits (235), Expect = 1e-19
Identities = 91/336 (27%), Positives = 142/336 (42%), Gaps = 64/336 (19%)
Query: 219 TFHFQCDCWLSKSEGDGQTVRDF----------------ACANNKICDEL------EETT 256
T++F C WL+ E DGQ R+ +N D L + TT
Sbjct: 6 TYYFPCQRWLAVEEDDGQLSRELLPVDESYVLPQSEEGRGGGDNNPLDNLALEQKDKSTT 65
Query: 257 YEIVIETG---NGGETRENVWLILEGRKNRSKEFLMENS-SRQRAFRKGTTDTFEFDSIY 312
+ + I+TG N G T NV++ L G ++ + L+++S + F + + + F +++
Sbjct: 66 FSVTIKTGVKKNAG-TDANVFITLFGTQDDTGMTLLKSSKTNSDKFERDSIEIFTVETLD 124
Query: 313 LGDIASLCVGHLAREDRFIPKRELAWHVKTITITEMEYGNVYFFNCDCLIPLKRK----- 367
LGD+ + +GH D + W V + + G F C +
Sbjct: 125 LGDLWKVRLGH----DN--TGKAPGWFVDWVEVDAPSLGKCMTFPCGRWLAKNEDDGSII 178
Query: 368 RKYFKVFEVTKTTESFASKVQSLVPVKYEVIVTTGYEPGAGTDANVFVTIFGANG----- 422
R F T+ F V YE+ + T AGTDAN+F+ I+G +
Sbjct: 179 RDLFHAELQTRLYTPF---------VPYEITLYTSDVFAAGTDANIFIIIYGCDAVCTQQ 229
Query: 423 ---DTGKRELKQKMRNLFERGSTDRFFLETLELGE-LRKVRLEHDSSGYCSGWLVEKVEV 478
T KRE KQ FER S RF +E ++GE + K+R+ H+++G GW V++
Sbjct: 230 KYLCTNKREQKQ----FFERKSASRFIVELEDVGEIIEKIRIGHNNTGMNPGWHCSHVDI 285
Query: 479 TN---TSTGVATI-FNCGRWLDKKRGDGLTWRDLFP 510
G T+ F C RWL D T R+L P
Sbjct: 286 RRLLPDKDGAETLTFPCDRWLATSEDDKKTIRELVP 321
>gi|239754889 PREDICTED: similar to hCG2036697 [Homo sapiens]
Length = 1029
Score = 95.9 bits (237), Expect = 8e-20
Identities = 55/127 (43%), Positives = 75/127 (59%), Gaps = 2/127 (1%)
Query: 385 SKVQSLVPVK-YEVIVTTGYEPGAGTDANVFVTIFGANGDTGKREL-KQKMRNLFERGST 442
SK Q ++PV YEV V TG AGT ANV+++I G GDTG R+L + K F RG T
Sbjct: 32 SKGQPVLPVTIYEVNVATGELWNAGTVANVYISIHGEKGDTGSRQLFRSKSSFNFLRGQT 91
Query: 443 DRFFLETLELGELRKVRLEHDSSGYCSGWLVEKVEVTNTSTGVATIFNCGRWLDKKRGDG 502
D FFLE + LG+L K+ + HD G +GW ++ V + + +T F C RWLD+ D
Sbjct: 92 DTFFLEAVHLGDLCKIVIGHDGLGPGNGWFLDDVVIKDPTTNYEYAFFCHRWLDQGEDDC 151
Query: 503 LTWRDLF 509
R+L+
Sbjct: 152 KIVRELY 158
Score = 92.8 bits (229), Expect = 7e-19
Identities = 57/165 (34%), Positives = 85/165 (51%), Gaps = 1/165 (0%)
Query: 84 MNTGDLTMFYYGDWLSQRKGKKTLVCEMCAVIDEEEMMEWTSYTVAVKTSDILGAGTDAN 143
MN+G WL++ + + E + + ++ T Y V V T ++ AGT AN
Sbjct: 1 MNSGKQFYVPVQRWLARDQEDGEICREFPLLSKGQPVLPVTIYEVNVATGELWNAGTVAN 60
Query: 144 VFIIIFGENGDSGTLALKQSANWNKFERNNTDTFNFPDMLSLGHLCKLRVWHDNKGIFPG 203
V+I I GE GD+G+ L +S + F R TDTF F + + LG LCK+ + HD G G
Sbjct: 61 VYISIHGEKGDTGSRQLFRSKSSFNFLRGQTDTF-FLEAVHLGDLCKIVIGHDGLGPGNG 119
Query: 204 WHLSYVDVKDNSRDETFHFQCDCWLSKSEGDGQTVRDFACANNKI 248
W L V +KD + + + F C WL + E D + VR+ +N I
Sbjct: 120 WFLDDVVIKDPTTNYEYAFFCHRWLDQGEDDCKIVRELYARDNSI 164
Score = 73.9 bits (180), Expect = 3e-13
Identities = 40/105 (38%), Positives = 62/105 (59%), Gaps = 1/105 (0%)
Query: 388 QSLVPVKYEVIVTTGYEPGAGTDANVFVTIFGANGDTGKREL-KQKMRNLFERGSTDRFF 446
Q++ P++Y+V V TG A T++ VF+ +FG GD+G R+L K M+ F+RG D+F
Sbjct: 629 QAIFPLRYQVDVYTGQLKHAETESEVFLCLFGERGDSGLRQLYKSNMQVKFQRGQIDKFQ 688
Query: 447 LETLELGELRKVRLEHDSSGYCSGWLVEKVEVTNTSTGVATIFNC 491
+ + LG+L+KV L ++S W E+V V T +IF C
Sbjct: 689 VAAVSLGKLQKVLLRCEASDKSQYWYCEQVIVREPGTTSESIFTC 733
Score = 66.2 bits (160), Expect = 7e-11
Identities = 37/115 (32%), Positives = 62/115 (53%), Gaps = 2/115 (1%)
Query: 1 MTVWTGDVVGGGTDSNIFMTLYGINGSTEEMQLDKKKARFE--REQNDTFIMEILDIAPF 58
+ V TG++ GT +N++++++G G T QL + K+ F R Q DTF +E + +
Sbjct: 45 VNVATGELWNAGTVANVYISIHGEKGDTGSRQLFRSKSSFNFLRGQTDTFFLEAVHLGDL 104
Query: 59 TKMRIRIDGLGSRPEWFLERILLKNMNTGDLTMFYYGDWLSQRKGKKTLVCEMCA 113
K+ I DGLG WFL+ +++K+ T F+ WL Q + +V E+ A
Sbjct: 105 CKIVIGHDGLGPGNGWFLDDVVIKDPTTNYEYAFFCHRWLDQGEDDCKIVRELYA 159
Score = 57.0 bits (136), Expect = 4e-08
Identities = 53/215 (24%), Positives = 86/215 (40%), Gaps = 33/215 (15%)
Query: 12 GTDSNIFMTLYGINGSTEEMQL--DKKKARFEREQNDTFIMEILDIAPFTKMRIRIDGLG 69
GT +N+ + +YG G T + L D + F D F
Sbjct: 550 GTQANVTLWVYGDKGVTGPISLRKDSSEQLFLPGHEDEF--------------------- 588
Query: 70 SRPEWFLERILLKNMNTGDLTMFYYGDWLSQRKGKKTLVCEMCAVIDEEEMMEWTSYTVA 129
++ +++M + + F WLS+ + +VCE+ V + + Y V
Sbjct: 589 --------QVTMQHMKSKKILDFAANVWLSRIQADGDVVCELPVVKGGQAIFP-LRYQVD 639
Query: 130 VKTSDILGAGTDANVFIIIFGENGDSGTLALKQSANWNKFERNNTDTFNFPDMLSLGHLC 189
V T + A T++ VF+ +FGE GDSG L +S KF+R D F +SLG L
Sbjct: 640 VYTGQLKHAETESEVFLCLFGERGDSGLRQLYKSNMQVKFQRGQIDKFQVA-AVSLGKLQ 698
Query: 190 KLRVWHDNKGIFPGWHLSYVDVKDNSRDETFHFQC 224
K+ + + W+ V V++ F C
Sbjct: 699 KVLLRCEASDKSQYWYCEQVIVREPGTTSESIFTC 733
Score = 55.8 bits (133), Expect = 9e-08
Identities = 40/142 (28%), Positives = 65/142 (45%), Gaps = 11/142 (7%)
Query: 220 FHFQCDCWLSKSEGDGQTVRDFACANNKICDELEETTYEIVIETG---NGGETRENVWLI 276
F+ WL++ + DG+ R+F + K L T YE+ + TG N G T NV++
Sbjct: 7 FYVPVQRWLARDQEDGEICREFPLLS-KGQPVLPVTIYEVNVATGELWNAG-TVANVYIS 64
Query: 277 LEGRKNRSKEFLMENSSRQRAFRKGTTDTFEFDSIYLGDIASLCVGHLAREDRFIPKREL 336
+ G K + + S F +G TDTF ++++LGD+ + +GH D P
Sbjct: 65 IHGEKGDTGSRQLFRSKSSFNFLRGQTDTFFLEAVHLGDLCKIVIGH----DGLGPGN-- 118
Query: 337 AWHVKTITITEMEYGNVYFFNC 358
W + + I + Y F C
Sbjct: 119 GWFLDDVVIKDPTTNYEYAFFC 140
Score = 49.3 bits (116), Expect = 8e-06
Identities = 49/246 (19%), Positives = 98/246 (39%), Gaps = 43/246 (17%)
Query: 118 EEMMEWTSYTVAVKTSDILGAGTDANVFIIIFGENGDSGTLALKQSANWNKFERNNTDTF 177
E ++ + V V T + GT ANV + ++G+ G +G ++L++ ++ F + D F
Sbjct: 532 ETLLSEDEWKVLVLTGN---TGTQANVTLWVYGDKGVTGPISLRKDSSEQLFLPGHEDEF 588
Query: 178 NFPDMLSLGHLCKLRVWHDNKGIFPGWHLSYVDVKDNSRDETFHFQCDCWLSKSEGDGQT 237
+++ H+ ++ F + WLS+ + DG
Sbjct: 589 Q----VTMQHMKSKKI--------------------------LDFAANVWLSRIQADGDV 618
Query: 238 VRDFACANNKICDELEETTYEIVIETG--NGGETRENVWLILEGRKNRSKEFLMENSSRQ 295
V + K + Y++ + TG ET V+L L G + S + S+ Q
Sbjct: 619 VCELPVV--KGGQAIFPLRYQVDVYTGQLKHAETESEVFLCLFGERGDSGLRQLYKSNMQ 676
Query: 296 RAFRKGTTDTFEFDSIYLGDIASLCVGHLAREDRFIPKRELAWHVKTITITEMEYGNVYF 355
F++G D F+ ++ LG + + + A + + W+ + + + E +
Sbjct: 677 VKFQRGQIDKFQVAAVSLGKLQKVLLRCEASD------KSQYWYCEQVIVREPGTTSESI 730
Query: 356 FNCDCL 361
F C L
Sbjct: 731 FTCQSL 736
Score = 44.7 bits (104), Expect = 2e-04
Identities = 23/92 (25%), Positives = 47/92 (51%), Gaps = 2/92 (2%)
Query: 3 VWTGDVVGGGTDSNIFMTLYGINGSTEEMQLDKK--KARFEREQNDTFIMEILDIAPFTK 60
V+TG + T+S +F+ L+G G + QL K + +F+R Q D F + + + K
Sbjct: 640 VYTGQLKHAETESEVFLCLFGERGDSGLRQLYKSNMQVKFQRGQIDKFQVAAVSLGKLQK 699
Query: 61 MRIRIDGLGSRPEWFLERILLKNMNTGDLTMF 92
+ +R + W+ E+++++ T ++F
Sbjct: 700 VLLRCEASDKSQYWYCEQVIVREPGTTSESIF 731
Score = 36.2 bits (82), Expect = 0.073
Identities = 22/65 (33%), Positives = 30/65 (46%), Gaps = 9/65 (13%)
Query: 121 MEWT--------SYTVAVKTSDILGAGTDANVFIIIFGENGDSGTLALKQSANWNKFERN 172
+EWT + V + T D+ AGT A VF+ ++GE SG + L S F N
Sbjct: 829 LEWTVLAGELDGDWKVTIVTGDLENAGTTATVFLYVYGETKCSGPIIL-GSGKHQLFNPN 887
Query: 173 NTDTF 177
D F
Sbjct: 888 TADIF 892
Score = 32.7 bits (73), Expect = 0.81
Identities = 24/69 (34%), Positives = 31/69 (44%), Gaps = 4/69 (5%)
Query: 378 KTTESFASKVQSLVPVKYEVIVTTGYEPGAGTDANVFVTIFGANGDTGKREL-KQKMRNL 436
K F S L +++V+V TG GT ANV + ++G G TG L K L
Sbjct: 523 KEIRHFQSSETLLSEDEWKVLVLTG---NTGTQANVTLWVYGDKGVTGPISLRKDSSEQL 579
Query: 437 FERGSTDRF 445
F G D F
Sbjct: 580 FLPGHEDEF 588
>gi|239749428 PREDICTED: hypothetical protein XP_002347033 [Homo
sapiens]
Length = 1029
Score = 95.9 bits (237), Expect = 8e-20
Identities = 55/127 (43%), Positives = 75/127 (59%), Gaps = 2/127 (1%)
Query: 385 SKVQSLVPVK-YEVIVTTGYEPGAGTDANVFVTIFGANGDTGKREL-KQKMRNLFERGST 442
SK Q ++PV YEV V TG AGT ANV+++I G GDTG R+L + K F RG T
Sbjct: 32 SKGQPVLPVTIYEVNVATGELWNAGTVANVYISIHGEKGDTGSRQLFRSKSSFNFLRGQT 91
Query: 443 DRFFLETLELGELRKVRLEHDSSGYCSGWLVEKVEVTNTSTGVATIFNCGRWLDKKRGDG 502
D FFLE + LG+L K+ + HD G +GW ++ V + + +T F C RWLD+ D
Sbjct: 92 DTFFLEAVHLGDLCKIVIGHDGLGPGNGWFLDDVVIKDPTTNYEYAFFCHRWLDQGEDDC 151
Query: 503 LTWRDLF 509
R+L+
Sbjct: 152 KIVRELY 158
Score = 92.8 bits (229), Expect = 7e-19
Identities = 57/165 (34%), Positives = 85/165 (51%), Gaps = 1/165 (0%)
Query: 84 MNTGDLTMFYYGDWLSQRKGKKTLVCEMCAVIDEEEMMEWTSYTVAVKTSDILGAGTDAN 143
MN+G WL++ + + E + + ++ T Y V V T ++ AGT AN
Sbjct: 1 MNSGKQFYVPVQRWLARDQEDGEICREFPLLSKGQPVLPVTIYEVNVATGELWNAGTVAN 60
Query: 144 VFIIIFGENGDSGTLALKQSANWNKFERNNTDTFNFPDMLSLGHLCKLRVWHDNKGIFPG 203
V+I I GE GD+G+ L +S + F R TDTF F + + LG LCK+ + HD G G
Sbjct: 61 VYISIHGEKGDTGSRQLFRSKSSFNFLRGQTDTF-FLEAVHLGDLCKIVIGHDGLGPGNG 119
Query: 204 WHLSYVDVKDNSRDETFHFQCDCWLSKSEGDGQTVRDFACANNKI 248
W L V +KD + + + F C WL + E D + VR+ +N I
Sbjct: 120 WFLDDVVIKDPTTNYEYAFFCHRWLDQGEDDCKIVRELYARDNSI 164
Score = 73.9 bits (180), Expect = 3e-13
Identities = 40/105 (38%), Positives = 62/105 (59%), Gaps = 1/105 (0%)
Query: 388 QSLVPVKYEVIVTTGYEPGAGTDANVFVTIFGANGDTGKREL-KQKMRNLFERGSTDRFF 446
Q++ P++Y+V V TG A T++ VF+ +FG GD+G R+L K M+ F+RG D+F
Sbjct: 629 QAIFPLRYQVDVYTGQLKHAETESEVFLCLFGERGDSGLRQLYKSNMQVKFQRGQIDKFQ 688
Query: 447 LETLELGELRKVRLEHDSSGYCSGWLVEKVEVTNTSTGVATIFNC 491
+ + LG+L+KV L ++S W E+V V T +IF C
Sbjct: 689 VAAVSLGKLQKVLLRCEASDKSQYWYCEQVIVREPGTTSESIFTC 733
Score = 66.2 bits (160), Expect = 7e-11
Identities = 37/115 (32%), Positives = 62/115 (53%), Gaps = 2/115 (1%)
Query: 1 MTVWTGDVVGGGTDSNIFMTLYGINGSTEEMQLDKKKARFE--REQNDTFIMEILDIAPF 58
+ V TG++ GT +N++++++G G T QL + K+ F R Q DTF +E + +
Sbjct: 45 VNVATGELWNAGTVANVYISIHGEKGDTGSRQLFRSKSSFNFLRGQTDTFFLEAVHLGDL 104
Query: 59 TKMRIRIDGLGSRPEWFLERILLKNMNTGDLTMFYYGDWLSQRKGKKTLVCEMCA 113
K+ I DGLG WFL+ +++K+ T F+ WL Q + +V E+ A
Sbjct: 105 CKIVIGHDGLGPGNGWFLDDVVIKDPTTNYEYAFFCHRWLDQGEDDCKIVRELYA 159
Score = 57.0 bits (136), Expect = 4e-08
Identities = 53/215 (24%), Positives = 86/215 (40%), Gaps = 33/215 (15%)
Query: 12 GTDSNIFMTLYGINGSTEEMQL--DKKKARFEREQNDTFIMEILDIAPFTKMRIRIDGLG 69
GT +N+ + +YG G T + L D + F D F
Sbjct: 550 GTQANVTLWVYGDKGVTGPISLRKDSSEQLFLPGHEDEF--------------------- 588
Query: 70 SRPEWFLERILLKNMNTGDLTMFYYGDWLSQRKGKKTLVCEMCAVIDEEEMMEWTSYTVA 129
++ +++M + + F WLS+ + +VCE+ V + + Y V
Sbjct: 589 --------QVTMQHMKSKKILDFAANVWLSRIQADGDVVCELPVVKGGQAIFP-LRYQVD 639
Query: 130 VKTSDILGAGTDANVFIIIFGENGDSGTLALKQSANWNKFERNNTDTFNFPDMLSLGHLC 189
V T + A T++ VF+ +FGE GDSG L +S KF+R D F +SLG L
Sbjct: 640 VYTGQLKHAETESEVFLCLFGERGDSGLRQLYKSNMQVKFQRGQIDKFQVA-AVSLGKLQ 698
Query: 190 KLRVWHDNKGIFPGWHLSYVDVKDNSRDETFHFQC 224
K+ + + W+ V V++ F C
Sbjct: 699 KVLLRCEASDKSQYWYCEQVIVREPGTTSESIFTC 733
Score = 55.8 bits (133), Expect = 9e-08
Identities = 40/142 (28%), Positives = 65/142 (45%), Gaps = 11/142 (7%)
Query: 220 FHFQCDCWLSKSEGDGQTVRDFACANNKICDELEETTYEIVIETG---NGGETRENVWLI 276
F+ WL++ + DG+ R+F + K L T YE+ + TG N G T NV++
Sbjct: 7 FYVPVQRWLARDQEDGEICREFPLLS-KGQPVLPVTIYEVNVATGELWNAG-TVANVYIS 64
Query: 277 LEGRKNRSKEFLMENSSRQRAFRKGTTDTFEFDSIYLGDIASLCVGHLAREDRFIPKREL 336
+ G K + + S F +G TDTF ++++LGD+ + +GH D P
Sbjct: 65 IHGEKGDTGSRQLFRSKSSFNFLRGQTDTFFLEAVHLGDLCKIVIGH----DGLGPGN-- 118
Query: 337 AWHVKTITITEMEYGNVYFFNC 358
W + + I + Y F C
Sbjct: 119 GWFLDDVVIKDPTTNYEYAFFC 140
Score = 49.3 bits (116), Expect = 8e-06
Identities = 49/246 (19%), Positives = 98/246 (39%), Gaps = 43/246 (17%)
Query: 118 EEMMEWTSYTVAVKTSDILGAGTDANVFIIIFGENGDSGTLALKQSANWNKFERNNTDTF 177
E ++ + V V T + GT ANV + ++G+ G +G ++L++ ++ F + D F
Sbjct: 532 ETLLSEDEWKVLVLTGN---TGTQANVTLWVYGDKGVTGPISLRKDSSEQLFLPGHEDEF 588
Query: 178 NFPDMLSLGHLCKLRVWHDNKGIFPGWHLSYVDVKDNSRDETFHFQCDCWLSKSEGDGQT 237
+++ H+ ++ F + WLS+ + DG
Sbjct: 589 Q----VTMQHMKSKKI--------------------------LDFAANVWLSRIQADGDV 618
Query: 238 VRDFACANNKICDELEETTYEIVIETG--NGGETRENVWLILEGRKNRSKEFLMENSSRQ 295
V + K + Y++ + TG ET V+L L G + S + S+ Q
Sbjct: 619 VCELPVV--KGGQAIFPLRYQVDVYTGQLKHAETESEVFLCLFGERGDSGLRQLYKSNMQ 676
Query: 296 RAFRKGTTDTFEFDSIYLGDIASLCVGHLAREDRFIPKRELAWHVKTITITEMEYGNVYF 355
F++G D F+ ++ LG + + + A + + W+ + + + E +
Sbjct: 677 VKFQRGQIDKFQVAAVSLGKLQKVLLRCEASD------KSQYWYCEQVIVREPGTTSESI 730
Query: 356 FNCDCL 361
F C L
Sbjct: 731 FTCQSL 736
Score = 44.7 bits (104), Expect = 2e-04
Identities = 23/92 (25%), Positives = 47/92 (51%), Gaps = 2/92 (2%)
Query: 3 VWTGDVVGGGTDSNIFMTLYGINGSTEEMQLDKK--KARFEREQNDTFIMEILDIAPFTK 60
V+TG + T+S +F+ L+G G + QL K + +F+R Q D F + + + K
Sbjct: 640 VYTGQLKHAETESEVFLCLFGERGDSGLRQLYKSNMQVKFQRGQIDKFQVAAVSLGKLQK 699
Query: 61 MRIRIDGLGSRPEWFLERILLKNMNTGDLTMF 92
+ +R + W+ E+++++ T ++F
Sbjct: 700 VLLRCEASDKSQYWYCEQVIVREPGTTSESIF 731
Score = 38.1 bits (87), Expect = 0.019
Identities = 27/92 (29%), Positives = 40/92 (43%), Gaps = 17/92 (18%)
Query: 94 YGDWLSQRKGKKTLVCEMCAVIDEEEMMEWT--------SYTVAVKTSDILGAGTDANVF 145
+G W + K K++ C + +EWT + V + T D+ AGT A VF
Sbjct: 810 HGAWKAVLKRKESHGCT--------QELEWTVLAGELDGDWKVTIVTGDLENAGTTATVF 861
Query: 146 IIIFGENGDSGTLALKQSANWNKFERNNTDTF 177
+ ++GE SG + L S F N D F
Sbjct: 862 LYVYGETKCSGPIIL-GSGKHQLFNPNTADIF 892
Score = 32.7 bits (73), Expect = 0.81
Identities = 24/69 (34%), Positives = 31/69 (44%), Gaps = 4/69 (5%)
Query: 378 KTTESFASKVQSLVPVKYEVIVTTGYEPGAGTDANVFVTIFGANGDTGKREL-KQKMRNL 436
K F S L +++V+V TG GT ANV + ++G G TG L K L
Sbjct: 523 KEIRHFQSSETLLSEDEWKVLVLTG---NTGTQANVTLWVYGDKGVTGPISLRKDSSEQL 579
Query: 437 FERGSTDRF 445
F G D F
Sbjct: 580 FLPGHEDEF 588
>gi|239743562 PREDICTED: hypothetical protein XP_002342894 [Homo
sapiens]
Length = 1029
Score = 95.9 bits (237), Expect = 8e-20
Identities = 55/127 (43%), Positives = 75/127 (59%), Gaps = 2/127 (1%)
Query: 385 SKVQSLVPVK-YEVIVTTGYEPGAGTDANVFVTIFGANGDTGKREL-KQKMRNLFERGST 442
SK Q ++PV YEV V TG AGT ANV+++I G GDTG R+L + K F RG T
Sbjct: 32 SKGQPVLPVTIYEVNVATGELWNAGTVANVYISIHGEKGDTGSRQLFRSKSSFNFLRGQT 91
Query: 443 DRFFLETLELGELRKVRLEHDSSGYCSGWLVEKVEVTNTSTGVATIFNCGRWLDKKRGDG 502
D FFLE + LG+L K+ + HD G +GW ++ V + + +T F C RWLD+ D
Sbjct: 92 DTFFLEAVHLGDLCKIVIGHDGLGPGNGWFLDDVVIKDPTTNYEYAFFCHRWLDQGEDDC 151
Query: 503 LTWRDLF 509
R+L+
Sbjct: 152 KIVRELY 158
Score = 92.8 bits (229), Expect = 7e-19
Identities = 57/165 (34%), Positives = 85/165 (51%), Gaps = 1/165 (0%)
Query: 84 MNTGDLTMFYYGDWLSQRKGKKTLVCEMCAVIDEEEMMEWTSYTVAVKTSDILGAGTDAN 143
MN+G WL++ + + E + + ++ T Y V V T ++ AGT AN
Sbjct: 1 MNSGKQFYVPVQRWLARDQEDGEICREFPLLSKGQPVLPVTIYEVNVATGELWNAGTVAN 60
Query: 144 VFIIIFGENGDSGTLALKQSANWNKFERNNTDTFNFPDMLSLGHLCKLRVWHDNKGIFPG 203
V+I I GE GD+G+ L +S + F R TDTF F + + LG LCK+ + HD G G
Sbjct: 61 VYISIHGEKGDTGSRQLFRSKSSFNFLRGQTDTF-FLEAVHLGDLCKIVIGHDGLGPGNG 119
Query: 204 WHLSYVDVKDNSRDETFHFQCDCWLSKSEGDGQTVRDFACANNKI 248
W L V +KD + + + F C WL + E D + VR+ +N I
Sbjct: 120 WFLDDVVIKDPTTNYEYAFFCHRWLDQGEDDCKIVRELYARDNSI 164
Score = 73.9 bits (180), Expect = 3e-13
Identities = 40/105 (38%), Positives = 62/105 (59%), Gaps = 1/105 (0%)
Query: 388 QSLVPVKYEVIVTTGYEPGAGTDANVFVTIFGANGDTGKREL-KQKMRNLFERGSTDRFF 446
Q++ P++Y+V V TG A T++ VF+ +FG GD+G R+L K M+ F+RG D+F
Sbjct: 629 QAIFPLRYQVDVYTGQLKHAETESEVFLCLFGERGDSGLRQLYKSNMQVKFQRGQIDKFQ 688
Query: 447 LETLELGELRKVRLEHDSSGYCSGWLVEKVEVTNTSTGVATIFNC 491
+ + LG+L+KV L ++S W E+V V T +IF C
Sbjct: 689 VAAVSLGKLQKVLLRCEASDKSQYWYCEQVIVREPGTTSESIFTC 733
Score = 66.2 bits (160), Expect = 7e-11
Identities = 37/115 (32%), Positives = 62/115 (53%), Gaps = 2/115 (1%)
Query: 1 MTVWTGDVVGGGTDSNIFMTLYGINGSTEEMQLDKKKARFE--REQNDTFIMEILDIAPF 58
+ V TG++ GT +N++++++G G T QL + K+ F R Q DTF +E + +
Sbjct: 45 VNVATGELWNAGTVANVYISIHGEKGDTGSRQLFRSKSSFNFLRGQTDTFFLEAVHLGDL 104
Query: 59 TKMRIRIDGLGSRPEWFLERILLKNMNTGDLTMFYYGDWLSQRKGKKTLVCEMCA 113
K+ I DGLG WFL+ +++K+ T F+ WL Q + +V E+ A
Sbjct: 105 CKIVIGHDGLGPGNGWFLDDVVIKDPTTNYEYAFFCHRWLDQGEDDCKIVRELYA 159
Score = 57.0 bits (136), Expect = 4e-08
Identities = 53/215 (24%), Positives = 86/215 (40%), Gaps = 33/215 (15%)
Query: 12 GTDSNIFMTLYGINGSTEEMQL--DKKKARFEREQNDTFIMEILDIAPFTKMRIRIDGLG 69
GT +N+ + +YG G T + L D + F D F
Sbjct: 550 GTQANVTLWVYGDKGVTGPISLRKDSSEQLFLPGHEDEF--------------------- 588
Query: 70 SRPEWFLERILLKNMNTGDLTMFYYGDWLSQRKGKKTLVCEMCAVIDEEEMMEWTSYTVA 129
++ +++M + + F WLS+ + +VCE+ V + + Y V
Sbjct: 589 --------QVTMQHMKSKKILDFAANVWLSRIQADGDVVCELPVVKGGQAIFP-LRYQVD 639
Query: 130 VKTSDILGAGTDANVFIIIFGENGDSGTLALKQSANWNKFERNNTDTFNFPDMLSLGHLC 189
V T + A T++ VF+ +FGE GDSG L +S KF+R D F +SLG L
Sbjct: 640 VYTGQLKHAETESEVFLCLFGERGDSGLRQLYKSNMQVKFQRGQIDKFQVA-AVSLGKLQ 698
Query: 190 KLRVWHDNKGIFPGWHLSYVDVKDNSRDETFHFQC 224
K+ + + W+ V V++ F C
Sbjct: 699 KVLLRCEASDKSQYWYCEQVIVREPGTTSESIFTC 733
Score = 55.8 bits (133), Expect = 9e-08
Identities = 40/142 (28%), Positives = 65/142 (45%), Gaps = 11/142 (7%)
Query: 220 FHFQCDCWLSKSEGDGQTVRDFACANNKICDELEETTYEIVIETG---NGGETRENVWLI 276
F+ WL++ + DG+ R+F + K L T YE+ + TG N G T NV++
Sbjct: 7 FYVPVQRWLARDQEDGEICREFPLLS-KGQPVLPVTIYEVNVATGELWNAG-TVANVYIS 64
Query: 277 LEGRKNRSKEFLMENSSRQRAFRKGTTDTFEFDSIYLGDIASLCVGHLAREDRFIPKREL 336
+ G K + + S F +G TDTF ++++LGD+ + +GH D P
Sbjct: 65 IHGEKGDTGSRQLFRSKSSFNFLRGQTDTFFLEAVHLGDLCKIVIGH----DGLGPGN-- 118
Query: 337 AWHVKTITITEMEYGNVYFFNC 358
W + + I + Y F C
Sbjct: 119 GWFLDDVVIKDPTTNYEYAFFC 140
Score = 49.3 bits (116), Expect = 8e-06
Identities = 49/246 (19%), Positives = 98/246 (39%), Gaps = 43/246 (17%)
Query: 118 EEMMEWTSYTVAVKTSDILGAGTDANVFIIIFGENGDSGTLALKQSANWNKFERNNTDTF 177
E ++ + V V T + GT ANV + ++G+ G +G ++L++ ++ F + D F
Sbjct: 532 ETLLSEDEWKVLVLTGN---TGTQANVTLWVYGDKGVTGPISLRKDSSEQLFLPGHEDEF 588
Query: 178 NFPDMLSLGHLCKLRVWHDNKGIFPGWHLSYVDVKDNSRDETFHFQCDCWLSKSEGDGQT 237
+++ H+ ++ F + WLS+ + DG
Sbjct: 589 Q----VTMQHMKSKKI--------------------------LDFAANVWLSRIQADGDV 618
Query: 238 VRDFACANNKICDELEETTYEIVIETG--NGGETRENVWLILEGRKNRSKEFLMENSSRQ 295
V + K + Y++ + TG ET V+L L G + S + S+ Q
Sbjct: 619 VCELPVV--KGGQAIFPLRYQVDVYTGQLKHAETESEVFLCLFGERGDSGLRQLYKSNMQ 676
Query: 296 RAFRKGTTDTFEFDSIYLGDIASLCVGHLAREDRFIPKRELAWHVKTITITEMEYGNVYF 355
F++G D F+ ++ LG + + + A + + W+ + + + E +
Sbjct: 677 VKFQRGQIDKFQVAAVSLGKLQKVLLRCEASD------KSQYWYCEQVIVREPGTTSESI 730
Query: 356 FNCDCL 361
F C L
Sbjct: 731 FTCQSL 736
Score = 44.7 bits (104), Expect = 2e-04
Identities = 23/92 (25%), Positives = 47/92 (51%), Gaps = 2/92 (2%)
Query: 3 VWTGDVVGGGTDSNIFMTLYGINGSTEEMQLDKK--KARFEREQNDTFIMEILDIAPFTK 60
V+TG + T+S +F+ L+G G + QL K + +F+R Q D F + + + K
Sbjct: 640 VYTGQLKHAETESEVFLCLFGERGDSGLRQLYKSNMQVKFQRGQIDKFQVAAVSLGKLQK 699
Query: 61 MRIRIDGLGSRPEWFLERILLKNMNTGDLTMF 92
+ +R + W+ E+++++ T ++F
Sbjct: 700 VLLRCEASDKSQYWYCEQVIVREPGTTSESIF 731
Score = 38.1 bits (87), Expect = 0.019
Identities = 27/92 (29%), Positives = 40/92 (43%), Gaps = 17/92 (18%)
Query: 94 YGDWLSQRKGKKTLVCEMCAVIDEEEMMEWT--------SYTVAVKTSDILGAGTDANVF 145
+G W + K K++ C + +EWT + V + T D+ AGT A VF
Sbjct: 810 HGAWKAVLKRKESHGCT--------QELEWTVLAGELDGDWKVTIVTGDLENAGTTATVF 861
Query: 146 IIIFGENGDSGTLALKQSANWNKFERNNTDTF 177
+ ++GE SG + L S F N D F
Sbjct: 862 LYVYGETKCSGPIIL-GSGKHQLFNPNTADIF 892
Score = 32.7 bits (73), Expect = 0.81
Identities = 24/69 (34%), Positives = 31/69 (44%), Gaps = 4/69 (5%)
Query: 378 KTTESFASKVQSLVPVKYEVIVTTGYEPGAGTDANVFVTIFGANGDTGKREL-KQKMRNL 436
K F S L +++V+V TG GT ANV + ++G G TG L K L
Sbjct: 523 KEIRHFQSSETLLSEDEWKVLVLTG---NTGTQANVTLWVYGDKGVTGPISLRKDSSEQL 579
Query: 437 FERGSTDRF 445
F G D F
Sbjct: 580 FLPGHEDEF 588
>gi|19923084 polycystin-1L1 [Homo sapiens]
Length = 2849
Score = 79.3 bits (194), Expect = 8e-15
Identities = 43/118 (36%), Positives = 61/118 (51%), Gaps = 1/118 (0%)
Query: 126 YTVAVKTSDILGAGTDANVFIIIFGENGDSGTLALKQSANWNKFERNNTDTFNFPDMLSL 185
Y V + T A + V+I++ G+NG S T L FERN+ TF L
Sbjct: 1798 YAVVIDTGFRAPARLTSKVYIVLCGDNGLSETKELSCPEK-PLFERNSRHTFILSAPAQL 1856
Query: 186 GHLCKLRVWHDNKGIFPGWHLSYVDVKDNSRDETFHFQCDCWLSKSEGDGQTVRDFAC 243
G L K+R+WHD++G PGW +S+V VK+ + + F CWLS DG+ R+ C
Sbjct: 1857 GLLRKIRLWHDSRGPSPGWFISHVMVKELHTGQGWFFPAQCWLSAGRHDGRVERELTC 1914
Score = 74.3 bits (181), Expect = 2e-13
Identities = 43/115 (37%), Positives = 57/115 (49%), Gaps = 1/115 (0%)
Query: 395 YEVIVTTGYEPGAGTDANVFVTIFGANGDTGKRELKQKMRNLFERGSTDRFFLET-LELG 453
Y V++ TG+ A + V++ + G NG + +EL + LFER S F L +LG
Sbjct: 1798 YAVVIDTGFRAPARLTSKVYIVLCGDNGLSETKELSCPEKPLFERNSRHTFILSAPAQLG 1857
Query: 454 ELRKVRLEHDSSGYCSGWLVEKVEVTNTSTGVATIFNCGRWLDKKRGDGLTWRDL 508
LRK+RL HDS G GW + V V TG F WL R DG R+L
Sbjct: 1858 LLRKIRLWHDSRGPSPGWFISHVMVKELHTGQGWFFPAQCWLSAGRHDGRVEREL 1912
Score = 48.9 bits (115), Expect = 1e-05
Identities = 28/87 (32%), Positives = 44/87 (50%), Gaps = 2/87 (2%)
Query: 15 SNIFMTLYGINGSTEEMQLD-KKKARFEREQNDTFIMEI-LDIAPFTKMRIRIDGLGSRP 72
S +++ L G NG +E +L +K FER TFI+ + K+R+ D G P
Sbjct: 1814 SKVYIVLCGDNGLSETKELSCPEKPLFERNSRHTFILSAPAQLGLLRKIRLWHDSRGPSP 1873
Query: 73 EWFLERILLKNMNTGDLTMFYYGDWLS 99
WF+ +++K ++TG F WLS
Sbjct: 1874 GWFISHVMVKELHTGQGWFFPAQCWLS 1900
>gi|239756622 PREDICTED: polycystic kidney disease 1-like 3 [Homo
sapiens]
Length = 1732
Score = 79.0 bits (193), Expect = 1e-14
Identities = 49/155 (31%), Positives = 71/155 (45%), Gaps = 5/155 (3%)
Query: 126 YTVAVKTSDILGAGTDANVFIIIFGENGDSGTLALKQSANWNKFERNNTDTFNFPDMLSL 185
Y + V T A T A V I ++G G S L FER D F SL
Sbjct: 745 YLIQVYTGYRRSAATTAKVVITLYGSEGRSEPHHLCDPQK-TVFERGGLDVFLLTTWTSL 803
Query: 186 GHLCKLRVWHDNKGIFPGWHLSYVDVKDNSRDETFHFQCDCWLSKSEGDGQTVRDFACAN 245
G+L LR+WHDN G+ P W++S V V D + +HF C+CWL+ GD + R F +
Sbjct: 804 GNLHSLRLWHDNSGVSPSWYVSQVIVCDMAVKRKWHFLCNCWLAVDLGDCELDRVFIPVS 863
Query: 246 NKICDELEETTYEIVIETGNGGETRENVWLILEGR 280
+ +++E T++ +WL + R
Sbjct: 864 KRELFSFRHLFSSMIVEK----FTQDYLWLSIATR 894
Score = 69.3 bits (168), Expect = 8e-12
Identities = 40/108 (37%), Positives = 53/108 (49%), Gaps = 1/108 (0%)
Query: 395 YEVIVTTGYEPGAGTDANVFVTIFGANGDTGKRELKQKMRNLFERGSTDRFFLET-LELG 453
Y + V TGY A T A V +T++G+ G + L + +FERG D F L T LG
Sbjct: 745 YLIQVYTGYRRSAATTAKVVITLYGSEGRSEPHHLCDPQKTVFERGGLDVFLLTTWTSLG 804
Query: 454 ELRKVRLEHDSSGYCSGWLVEKVEVTNTSTGVATIFNCGRWLDKKRGD 501
L +RL HD+SG W V +V V + + F C WL GD
Sbjct: 805 NLHSLRLWHDNSGVSPSWYVSQVIVCDMAVKRKWHFLCNCWLAVDLGD 852
Score = 42.4 bits (98), Expect = 0.001
Identities = 27/99 (27%), Positives = 46/99 (46%), Gaps = 2/99 (2%)
Query: 3 VWTGDVVGGGTDSNIFMTLYGINGSTEEMQL-DKKKARFEREQNDTFIMEI-LDIAPFTK 60
V+TG T + + +TLYG G +E L D +K FER D F++ +
Sbjct: 749 VYTGYRRSAATTAKVVITLYGSEGRSEPHHLCDPQKTVFERGGLDVFLLTTWTSLGNLHS 808
Query: 61 MRIRIDGLGSRPEWFLERILLKNMNTGDLTMFYYGDWLS 99
+R+ D G P W++ ++++ +M F WL+
Sbjct: 809 LRLWHDNSGVSPSWYVSQVIVCDMAVKRKWHFLCNCWLA 847
Score = 29.6 bits (65), Expect = 6.8
Identities = 32/134 (23%), Positives = 58/134 (43%), Gaps = 13/134 (9%)
Query: 230 KSEGDGQTVRDFACANNKICDELEETTYEIVIETG--NGGETRENVWLILEGRKNRSKEF 287
K + D Q V+ A+N D + Y I + TG T V + L G + RS+
Sbjct: 721 KDQADMQKVKVTVLADN---DPSAQFHYLIQVYTGYRRSAATTAKVVITLYGSEGRSEPH 777
Query: 288 LMENSSRQRAFRKGTTDTFEFDS-IYLGDIASLCVGHLAREDRFIPKRELAWHVKTITIT 346
+ + + F +G D F + LG++ SL + H ++ + +W+V + +
Sbjct: 778 HLCDPQKT-VFERGGLDVFLLTTWTSLGNLHSLRLWH---DNSGVSP---SWYVSQVIVC 830
Query: 347 EMEYGNVYFFNCDC 360
+M + F C+C
Sbjct: 831 DMAVKRKWHFLCNC 844
>gi|239751108 PREDICTED: polycystic kidney disease 1-like 3 [Homo
sapiens]
Length = 1731
Score = 79.0 bits (193), Expect = 1e-14
Identities = 49/155 (31%), Positives = 71/155 (45%), Gaps = 5/155 (3%)
Query: 126 YTVAVKTSDILGAGTDANVFIIIFGENGDSGTLALKQSANWNKFERNNTDTFNFPDMLSL 185
Y + V T A T A V I ++G G S L FER D F SL
Sbjct: 745 YLIQVYTGYRRSAATTAKVVITLYGSEGRSEPHHLCDPQK-TVFERGGLDVFLLTTWTSL 803
Query: 186 GHLCKLRVWHDNKGIFPGWHLSYVDVKDNSRDETFHFQCDCWLSKSEGDGQTVRDFACAN 245
G+L LR+WHDN G+ P W++S V V D + +HF C+CWL+ GD + R F +
Sbjct: 804 GNLHSLRLWHDNSGVSPSWYVSQVIVCDMAVKRKWHFLCNCWLAVDLGDCELDRVFIPVS 863
Query: 246 NKICDELEETTYEIVIETGNGGETRENVWLILEGR 280
+ +++E T++ +WL + R
Sbjct: 864 KRELFSFRHLFSSMIVEK----FTQDYLWLSIATR 894
Score = 69.3 bits (168), Expect = 8e-12
Identities = 40/108 (37%), Positives = 53/108 (49%), Gaps = 1/108 (0%)
Query: 395 YEVIVTTGYEPGAGTDANVFVTIFGANGDTGKRELKQKMRNLFERGSTDRFFLET-LELG 453
Y + V TGY A T A V +T++G+ G + L + +FERG D F L T LG
Sbjct: 745 YLIQVYTGYRRSAATTAKVVITLYGSEGRSEPHHLCDPQKTVFERGGLDVFLLTTWTSLG 804
Query: 454 ELRKVRLEHDSSGYCSGWLVEKVEVTNTSTGVATIFNCGRWLDKKRGD 501
L +RL HD+SG W V +V V + + F C WL GD
Sbjct: 805 NLHSLRLWHDNSGVSPSWYVSQVIVCDMAVKRKWHFLCNCWLAVDLGD 852
Score = 42.4 bits (98), Expect = 0.001
Identities = 27/99 (27%), Positives = 46/99 (46%), Gaps = 2/99 (2%)
Query: 3 VWTGDVVGGGTDSNIFMTLYGINGSTEEMQL-DKKKARFEREQNDTFIMEI-LDIAPFTK 60
V+TG T + + +TLYG G +E L D +K FER D F++ +
Sbjct: 749 VYTGYRRSAATTAKVVITLYGSEGRSEPHHLCDPQKTVFERGGLDVFLLTTWTSLGNLHS 808
Query: 61 MRIRIDGLGSRPEWFLERILLKNMNTGDLTMFYYGDWLS 99
+R+ D G P W++ ++++ +M F WL+
Sbjct: 809 LRLWHDNSGVSPSWYVSQVIVCDMAVKRKWHFLCNCWLA 847
Score = 29.6 bits (65), Expect = 6.8
Identities = 32/134 (23%), Positives = 58/134 (43%), Gaps = 13/134 (9%)
Query: 230 KSEGDGQTVRDFACANNKICDELEETTYEIVIETG--NGGETRENVWLILEGRKNRSKEF 287
K + D Q V+ A+N D + Y I + TG T V + L G + RS+
Sbjct: 721 KDQADMQKVKVTVLADN---DPSAQFHYLIQVYTGYRRSAATTAKVVITLYGSEGRSEPH 777
Query: 288 LMENSSRQRAFRKGTTDTFEFDS-IYLGDIASLCVGHLAREDRFIPKRELAWHVKTITIT 346
+ + + F +G D F + LG++ SL + H ++ + +W+V + +
Sbjct: 778 HLCDPQKT-VFERGGLDVFLLTTWTSLGNLHSLRLWH---DNSGVSP---SWYVSQVIVC 830
Query: 347 EMEYGNVYFFNCDC 360
+M + F C+C
Sbjct: 831 DMAVKRKWHFLCNC 844
>gi|239745596 PREDICTED: polycystin 1-like 3 [Homo sapiens]
Length = 1731
Score = 79.0 bits (193), Expect = 1e-14
Identities = 49/155 (31%), Positives = 71/155 (45%), Gaps = 5/155 (3%)
Query: 126 YTVAVKTSDILGAGTDANVFIIIFGENGDSGTLALKQSANWNKFERNNTDTFNFPDMLSL 185
Y + V T A T A V I ++G G S L FER D F SL
Sbjct: 745 YLIQVYTGYRRSAATTAKVVITLYGSEGRSEPHHLCDPQK-TVFERGGLDVFLLTTWTSL 803
Query: 186 GHLCKLRVWHDNKGIFPGWHLSYVDVKDNSRDETFHFQCDCWLSKSEGDGQTVRDFACAN 245
G+L LR+WHDN G+ P W++S V V D + +HF C+CWL+ GD + R F +
Sbjct: 804 GNLHSLRLWHDNSGVSPSWYVSQVIVCDMAVKRKWHFLCNCWLAVDLGDCELDRVFIPVS 863
Query: 246 NKICDELEETTYEIVIETGNGGETRENVWLILEGR 280
+ +++E T++ +WL + R
Sbjct: 864 KRELFSFRHLFSSMIVEK----FTQDYLWLSIATR 894
Score = 69.3 bits (168), Expect = 8e-12
Identities = 40/108 (37%), Positives = 53/108 (49%), Gaps = 1/108 (0%)
Query: 395 YEVIVTTGYEPGAGTDANVFVTIFGANGDTGKRELKQKMRNLFERGSTDRFFLET-LELG 453
Y + V TGY A T A V +T++G+ G + L + +FERG D F L T LG
Sbjct: 745 YLIQVYTGYRRSAATTAKVVITLYGSEGRSEPHHLCDPQKTVFERGGLDVFLLTTWTSLG 804
Query: 454 ELRKVRLEHDSSGYCSGWLVEKVEVTNTSTGVATIFNCGRWLDKKRGD 501
L +RL HD+SG W V +V V + + F C WL GD
Sbjct: 805 NLHSLRLWHDNSGVSPSWYVSQVIVCDMAVKRKWHFLCNCWLAVDLGD 852
Score = 42.4 bits (98), Expect = 0.001
Identities = 27/99 (27%), Positives = 46/99 (46%), Gaps = 2/99 (2%)
Query: 3 VWTGDVVGGGTDSNIFMTLYGINGSTEEMQL-DKKKARFEREQNDTFIMEI-LDIAPFTK 60
V+TG T + + +TLYG G +E L D +K FER D F++ +
Sbjct: 749 VYTGYRRSAATTAKVVITLYGSEGRSEPHHLCDPQKTVFERGGLDVFLLTTWTSLGNLHS 808
Query: 61 MRIRIDGLGSRPEWFLERILLKNMNTGDLTMFYYGDWLS 99
+R+ D G P W++ ++++ +M F WL+
Sbjct: 809 LRLWHDNSGVSPSWYVSQVIVCDMAVKRKWHFLCNCWLA 847
Score = 29.6 bits (65), Expect = 6.8
Identities = 32/134 (23%), Positives = 58/134 (43%), Gaps = 13/134 (9%)
Query: 230 KSEGDGQTVRDFACANNKICDELEETTYEIVIETG--NGGETRENVWLILEGRKNRSKEF 287
K + D Q V+ A+N D + Y I + TG T V + L G + RS+
Sbjct: 721 KDQADMQKVKVTVLADN---DPSAQFHYLIQVYTGYRRSAATTAKVVITLYGSEGRSEPH 777
Query: 288 LMENSSRQRAFRKGTTDTFEFDS-IYLGDIASLCVGHLAREDRFIPKRELAWHVKTITIT 346
+ + + F +G D F + LG++ SL + H ++ + +W+V + +
Sbjct: 778 HLCDPQKT-VFERGGLDVFLLTTWTSLGNLHSLRLWH---DNSGVSP---SWYVSQVIVC 830
Query: 347 EMEYGNVYFFNCDC 360
+M + F C+C
Sbjct: 831 DMAVKRKWHFLCNC 844
>gi|31559825 polycystin 1-like 3 [Homo sapiens]
Length = 1732
Score = 79.0 bits (193), Expect = 1e-14
Identities = 49/155 (31%), Positives = 71/155 (45%), Gaps = 5/155 (3%)
Query: 126 YTVAVKTSDILGAGTDANVFIIIFGENGDSGTLALKQSANWNKFERNNTDTFNFPDMLSL 185
Y + V T A T A V I ++G G S L FER D F SL
Sbjct: 745 YLIQVYTGYRRSAATTAKVVITLYGSEGRSEPHHLCDPQK-TVFERGGLDVFLLTTWTSL 803
Query: 186 GHLCKLRVWHDNKGIFPGWHLSYVDVKDNSRDETFHFQCDCWLSKSEGDGQTVRDFACAN 245
G+L LR+WHDN G+ P W++S V V D + +HF C+CWL+ GD + R F +
Sbjct: 804 GNLHSLRLWHDNSGVSPSWYVSQVIVCDMAVKRKWHFLCNCWLAVDLGDCELDRVFIPVS 863
Query: 246 NKICDELEETTYEIVIETGNGGETRENVWLILEGR 280
+ +++E T++ +WL + R
Sbjct: 864 KRELFSFRHLFSSMIVEK----FTQDYLWLSIATR 894
Score = 69.3 bits (168), Expect = 8e-12
Identities = 40/108 (37%), Positives = 53/108 (49%), Gaps = 1/108 (0%)
Query: 395 YEVIVTTGYEPGAGTDANVFVTIFGANGDTGKRELKQKMRNLFERGSTDRFFLET-LELG 453
Y + V TGY A T A V +T++G+ G + L + +FERG D F L T LG
Sbjct: 745 YLIQVYTGYRRSAATTAKVVITLYGSEGRSEPHHLCDPQKTVFERGGLDVFLLTTWTSLG 804
Query: 454 ELRKVRLEHDSSGYCSGWLVEKVEVTNTSTGVATIFNCGRWLDKKRGD 501
L +RL HD+SG W V +V V + + F C WL GD
Sbjct: 805 NLHSLRLWHDNSGVSPSWYVSQVIVCDMAVKRKWHFLCNCWLAVDLGD 852
Score = 42.4 bits (98), Expect = 0.001
Identities = 27/99 (27%), Positives = 46/99 (46%), Gaps = 2/99 (2%)
Query: 3 VWTGDVVGGGTDSNIFMTLYGINGSTEEMQL-DKKKARFEREQNDTFIMEI-LDIAPFTK 60
V+TG T + + +TLYG G +E L D +K FER D F++ +
Sbjct: 749 VYTGYRRSAATTAKVVITLYGSEGRSEPHHLCDPQKTVFERGGLDVFLLTTWTSLGNLHS 808
Query: 61 MRIRIDGLGSRPEWFLERILLKNMNTGDLTMFYYGDWLS 99
+R+ D G P W++ ++++ +M F WL+
Sbjct: 809 LRLWHDNSGVSPSWYVSQVIVCDMAVKRKWHFLCNCWLA 847
Score = 29.6 bits (65), Expect = 6.8
Identities = 32/134 (23%), Positives = 58/134 (43%), Gaps = 13/134 (9%)
Query: 230 KSEGDGQTVRDFACANNKICDELEETTYEIVIETG--NGGETRENVWLILEGRKNRSKEF 287
K + D Q V+ A+N D + Y I + TG T V + L G + RS+
Sbjct: 721 KDQADMQKVKVTVLADN---DPSAQFHYLIQVYTGYRRSAATTAKVVITLYGSEGRSEPH 777
Query: 288 LMENSSRQRAFRKGTTDTFEFDS-IYLGDIASLCVGHLAREDRFIPKRELAWHVKTITIT 346
+ + + F +G D F + LG++ SL + H ++ + +W+V + +
Sbjct: 778 HLCDPQKT-VFERGGLDVFLLTTWTSLGNLHSLRLWH---DNSGVSP---SWYVSQVIVC 830
Query: 347 EMEYGNVYFFNCDC 360
+M + F C+C
Sbjct: 831 DMAVKRKWHFLCNC 844
>gi|205360962 polycystin 1 isoform 2 precursor [Homo sapiens]
Length = 4302
Score = 75.1 bits (183), Expect = 1e-13
Identities = 52/161 (32%), Positives = 79/161 (49%), Gaps = 7/161 (4%)
Query: 126 YTVAVKTSDILGAGTDANVFIIIFGENGDSGTLALKQSANWNKFERNNTDTFNFPDMLSL 185
Y + VKT G+GT A+V I+++G + SG L F RN+ D F SL
Sbjct: 3120 YEILVKTGWGRGSGTTAHVGIMLYGVDSRSGHRHLDGD---RAFHRNSLDIFRIATPHSL 3176
Query: 186 GHLCKLRVWHDNKGIFPGWHLSYVDVKDNSRDETFHFQCDCWLS-KSEGDGQTVRDFACA 244
G + K+RVWHDNKG+ P W L +V V+D + F + WLS ++E +G V A
Sbjct: 3177 GSVWKIRVWHDNKGLSPAWFLQHVIVRDLQTARSAFFLVNDWLSVETEANGGLVEKEVLA 3236
Query: 245 NNKICDELEETTYEIVIETGNGGETRENVWLILEGRKNRSK 285
+ D +++ G +++WL + R RS+
Sbjct: 3237 AS---DAALLRFRRLLVAELQRGFFDKHIWLSIWDRPPRSR 3274
Score = 62.0 bits (149), Expect = 1e-09
Identities = 35/103 (33%), Positives = 54/103 (52%), Gaps = 3/103 (2%)
Query: 394 KYEVIVTTGYEPGAGTDANVFVTIFGANGDTGKRELKQKMRNLFERGSTDRFFLET-LEL 452
KYE++V TG+ G+GT A+V + ++G + +G R L F R S D F + T L
Sbjct: 3119 KYEILVKTGWGRGSGTTAHVGIMLYGVDSRSGHRHLDGD--RAFHRNSLDIFRIATPHSL 3176
Query: 453 GELRKVRLEHDSSGYCSGWLVEKVEVTNTSTGVATIFNCGRWL 495
G + K+R+ HD+ G W ++ V V + T + F WL
Sbjct: 3177 GSVWKIRVWHDNKGLSPAWFLQHVIVRDLQTARSAFFLVNDWL 3219
Score = 52.8 bits (125), Expect = 8e-07
Identities = 31/98 (31%), Positives = 49/98 (50%), Gaps = 2/98 (2%)
Query: 3 VWTGDVVGGGTDSNIFMTLYGINGSTEEMQLDKKKARFEREQNDTF-IMEILDIAPFTKM 61
V TG G GT +++ + LYG++ + LD +A F R D F I + K+
Sbjct: 3124 VKTGWGRGSGTTAHVGIMLYGVDSRSGHRHLDGDRA-FHRNSLDIFRIATPHSLGSVWKI 3182
Query: 62 RIRIDGLGSRPEWFLERILLKNMNTGDLTMFYYGDWLS 99
R+ D G P WFL+ ++++++ T F DWLS
Sbjct: 3183 RVWHDNKGLSPAWFLQHVIVRDLQTARSAFFLVNDWLS 3220
>gi|205360954 polycystin 1 isoform 1 precursor [Homo sapiens]
Length = 4303
Score = 75.1 bits (183), Expect = 1e-13
Identities = 52/161 (32%), Positives = 79/161 (49%), Gaps = 7/161 (4%)
Query: 126 YTVAVKTSDILGAGTDANVFIIIFGENGDSGTLALKQSANWNKFERNNTDTFNFPDMLSL 185
Y + VKT G+GT A+V I+++G + SG L F RN+ D F SL
Sbjct: 3120 YEILVKTGWGRGSGTTAHVGIMLYGVDSRSGHRHLDGD---RAFHRNSLDIFRIATPHSL 3176
Query: 186 GHLCKLRVWHDNKGIFPGWHLSYVDVKDNSRDETFHFQCDCWLS-KSEGDGQTVRDFACA 244
G + K+RVWHDNKG+ P W L +V V+D + F + WLS ++E +G V A
Sbjct: 3177 GSVWKIRVWHDNKGLSPAWFLQHVIVRDLQTARSAFFLVNDWLSVETEANGGLVEKEVLA 3236
Query: 245 NNKICDELEETTYEIVIETGNGGETRENVWLILEGRKNRSK 285
+ D +++ G +++WL + R RS+
Sbjct: 3237 AS---DAALLRFRRLLVAELQRGFFDKHIWLSIWDRPPRSR 3274
Score = 62.0 bits (149), Expect = 1e-09
Identities = 35/103 (33%), Positives = 54/103 (52%), Gaps = 3/103 (2%)
Query: 394 KYEVIVTTGYEPGAGTDANVFVTIFGANGDTGKRELKQKMRNLFERGSTDRFFLET-LEL 452
KYE++V TG+ G+GT A+V + ++G + +G R L F R S D F + T L
Sbjct: 3119 KYEILVKTGWGRGSGTTAHVGIMLYGVDSRSGHRHLDGD--RAFHRNSLDIFRIATPHSL 3176
Query: 453 GELRKVRLEHDSSGYCSGWLVEKVEVTNTSTGVATIFNCGRWL 495
G + K+R+ HD+ G W ++ V V + T + F WL
Sbjct: 3177 GSVWKIRVWHDNKGLSPAWFLQHVIVRDLQTARSAFFLVNDWL 3219
Score = 52.8 bits (125), Expect = 8e-07
Identities = 31/98 (31%), Positives = 49/98 (50%), Gaps = 2/98 (2%)
Query: 3 VWTGDVVGGGTDSNIFMTLYGINGSTEEMQLDKKKARFEREQNDTF-IMEILDIAPFTKM 61
V TG G GT +++ + LYG++ + LD +A F R D F I + K+
Sbjct: 3124 VKTGWGRGSGTTAHVGIMLYGVDSRSGHRHLDGDRA-FHRNSLDIFRIATPHSLGSVWKI 3182
Query: 62 RIRIDGLGSRPEWFLERILLKNMNTGDLTMFYYGDWLS 99
R+ D G P WFL+ ++++++ T F DWLS
Sbjct: 3183 RVWHDNKGLSPAWFLQHVIVRDLQTARSAFFLVNDWLS 3220
>gi|116006951 polycystin 1-like 2 isoform a [Homo sapiens]
Length = 2459
Score = 74.7 bits (182), Expect = 2e-13
Identities = 44/108 (40%), Positives = 56/108 (51%), Gaps = 1/108 (0%)
Query: 395 YEVIVTTGYEPGAGTDANVFVTIFGANGDTGKRELKQKMRNLFERGSTDRFFLETL-ELG 453
Y V V TG+ GA T + V VT++G +G+ L +FERG+ D F L TL LG
Sbjct: 1392 YLVTVYTGHRRGAATSSKVTVTLYGLDGEREPHHLADPDTPVFERGAVDAFLLSTLFPLG 1451
Query: 454 ELRKVRLEHDSSGYCSGWLVEKVEVTNTSTGVATIFNCGRWLDKKRGD 501
ELR +RL HD+SG W V +V V + F C WL GD
Sbjct: 1452 ELRSLRLWHDNSGDRPSWYVSRVLVYDLVMDRKWYFLCNSWLSINVGD 1499
Score = 72.4 bits (176), Expect = 9e-13
Identities = 43/136 (31%), Positives = 65/136 (47%), Gaps = 1/136 (0%)
Query: 99 SQRKGKKTLVCEMCAVIDEEEMMEWTSYTVAVKTSDILGAGTDANVFIIIFGENGDSGTL 158
++RK + V+++ + Y V V T GA T + V + ++G +G+
Sbjct: 1365 ARRKDAQDQAKVKVTVLEDNDPFAQYHYLVTVYTGHRRGAATSSKVTVTLYGLDGEREPH 1424
Query: 159 ALKQSANWNKFERNNTDTFNFPDMLSLGHLCKLRVWHDNKGIFPGWHLSYVDVKDNSRDE 218
L + FER D F + LG L LR+WHDN G P W++S V V D D
Sbjct: 1425 HLADP-DTPVFERGAVDAFLLSTLFPLGELRSLRLWHDNSGDRPSWYVSRVLVYDLVMDR 1483
Query: 219 TFHFQCDCWLSKSEGD 234
++F C+ WLS + GD
Sbjct: 1484 KWYFLCNSWLSINVGD 1499
Score = 57.8 bits (138), Expect = 2e-08
Identities = 40/135 (29%), Positives = 63/135 (46%), Gaps = 4/135 (2%)
Query: 1 MTVWTGDVVGGGTDSNIFMTLYGINGSTEEMQL-DKKKARFEREQNDTFIMEIL-DIAPF 58
+TV+TG G T S + +TLYG++G E L D FER D F++ L +
Sbjct: 1394 VTVYTGHRRGAATSSKVTVTLYGLDGEREPHHLADPDTPVFERGAVDAFLLSTLFPLGEL 1453
Query: 59 TKMRIRIDGLGSRPEWFLERILLKNMNTGDLTMFYYGDWLSQRKGKKTLVCEMCAVIDEE 118
+R+ D G RP W++ R+L+ ++ F WLS G V + + E
Sbjct: 1454 RSLRLWHDNSGDRPSWYVSRVLVYDLVMDRKWYFLCNSWLSINVG--DCVLDKVFPVATE 1511
Query: 119 EMMEWTSYTVAVKTS 133
+ + S+ +KTS
Sbjct: 1512 QDRKQFSHLFFMKTS 1526
>gi|44889475 RAB6 interacting protein 1 [Homo sapiens]
Length = 1287
Score = 63.9 bits (154), Expect = 3e-10
Identities = 48/175 (27%), Positives = 81/175 (46%), Gaps = 18/175 (10%)
Query: 333 KRELAWHVKTIT----ITEMEYGNVYFFNCDCLIPLKRKRKYFKVFEVTKTTESFASKVQ 388
K+ L+ H+K + +T+ Y F CD ++++ + + + V
Sbjct: 894 KKLLSRHLKQLLSDHELTKKLYKRYAFLRCDD----EKEQFLYHLLSFNAVDYFCFTNVF 949
Query: 389 SLVPVKYEVIVTTGYEPGAGT-DANVFVTIFGANGDTGKRELKQKMRNLFERGSTDRFFL 447
+ + + Y +++ + G AN ++ I +G+ G+ ++ Q RN+ E
Sbjct: 950 TTILIPYHILIVPSKKLGGSMFTANPWICI---SGELGETQIMQIPRNVLE------MTF 1000
Query: 448 ETLELGELRKVRLEHDSSGYCSGWLVEKVEVTNTSTGVATIFNCGRWLDKKRGDG 502
E LG+L V++ HD+SG + WLVE V V N TG F CGRWL K DG
Sbjct: 1001 ECQNLGKLTTVQIGHDNSGLYAKWLVEYVMVRNEITGHTYKFPCGRWLGKGMDDG 1055
Score = 53.9 bits (128), Expect = 3e-07
Identities = 32/114 (28%), Positives = 53/114 (46%), Gaps = 11/114 (9%)
Query: 126 YTVAVKTSDILGAGTDANVFIIIFGENGDSGTLALKQSANWNKFERNNTDTFNFPDMLSL 185
+ + V + + G+ AN +I I GE G++ + + ++ FE N L
Sbjct: 957 HILIVPSKKLGGSMFTANPWICISGELGETQIMQIPRNVLEMTFECQN-----------L 1005
Query: 186 GHLCKLRVWHDNKGIFPGWHLSYVDVKDNSRDETFHFQCDCWLSKSEGDGQTVR 239
G L +++ HDN G++ W + YV V++ T+ F C WL K DG R
Sbjct: 1006 GKLTTVQIGHDNSGLYAKWLVEYVMVRNEITGHTYKFPCGRWLGKGMDDGSLER 1059
Score = 32.3 bits (72), Expect = 1.1
Identities = 22/86 (25%), Positives = 40/86 (46%), Gaps = 8/86 (9%)
Query: 15 SNIFMTLYGINGSTEEMQLDKKKARFEREQNDTFIMEILDIAPFTKMRIRIDGLGSRPEW 74
+N ++ + G G T+ MQ+ + TF E ++ T ++I D G +W
Sbjct: 973 ANPWICISGELGETQIMQIPRNVLEM------TF--ECQNLGKLTTVQIGHDNSGLYAKW 1024
Query: 75 FLERILLKNMNTGDLTMFYYGDWLSQ 100
+E ++++N TG F G WL +
Sbjct: 1025 LVEYVMVRNEITGHTYKFPCGRWLGK 1050
>gi|122891862 DENN/MADD domain containing 5B [Homo sapiens]
Length = 1274
Score = 61.2 bits (147), Expect = 2e-09
Identities = 49/177 (27%), Positives = 81/177 (45%), Gaps = 18/177 (10%)
Query: 331 IPKRELAWHVKTIT----ITEMEYGNVYFFNCDCLIPLKRKRKYFKVFEVTKTTESFASK 386
+ K+ L+ H+K + +T+ Y F C+ +R++ + + + +
Sbjct: 874 LEKKLLSQHLKQLLSNQPLTKKLYKRYAFLRCE----EEREQFLYHLLSLNAVDYFCFTS 929
Query: 387 VQSLVPVKYE-VIVTTGYEPGAGTDANVFVTIFGANGDTGKRELKQKMRNLFERGSTDRF 445
V + + + Y VI+ A +N ++ + G GDTG ++ +NL E
Sbjct: 930 VFTTIMIPYRSVIIPIKKLSNAIITSNPWICVSGELGDTGVMQIP---KNLLE------M 980
Query: 446 FLETLELGELRKVRLEHDSSGYCSGWLVEKVEVTNTSTGVATIFNCGRWLDKKRGDG 502
E LG+L V++ HD+SG + WLV+ V V N TG F CGRWL K DG
Sbjct: 981 TFECQNLGKLTTVQIGHDNSGLLAKWLVDCVMVRNEITGHTYRFPCGRWLGKGIDDG 1037
Score = 52.0 bits (123), Expect = 1e-06
Identities = 31/113 (27%), Positives = 50/113 (44%), Gaps = 11/113 (9%)
Query: 127 TVAVKTSDILGAGTDANVFIIIFGENGDSGTLALKQSANWNKFERNNTDTFNFPDMLSLG 186
+V + + A +N +I + GE GD+G + + ++ FE N LG
Sbjct: 940 SVIIPIKKLSNAIITSNPWICVSGELGDTGVMQIPKNLLEMTFECQN-----------LG 988
Query: 187 HLCKLRVWHDNKGIFPGWHLSYVDVKDNSRDETFHFQCDCWLSKSEGDGQTVR 239
L +++ HDN G+ W + V V++ T+ F C WL K DG R
Sbjct: 989 KLTTVQIGHDNSGLLAKWLVDCVMVRNEITGHTYRFPCGRWLGKGIDDGSLER 1041
Score = 32.3 bits (72), Expect = 1.1
Identities = 28/114 (24%), Positives = 52/114 (45%), Gaps = 16/114 (14%)
Query: 15 SNIFMTLYGINGSTEEMQLDKKKARFEREQNDTFIMEILDIAPFTKMRIRIDGLGSRPEW 74
SN ++ + G G T MQ+ K TF E ++ T ++I D G +W
Sbjct: 955 SNPWICVSGELGDTGVMQIPKNLLEM------TF--ECQNLGKLTTVQIGHDNSGLLAKW 1006
Query: 75 FLERILLKNMNTGDLTMFYYGDWLSQRKG------KKTLVCEMCAVIDEEEMME 122
++ ++++N TG F G WL KG ++ L+ E+ +E++++
Sbjct: 1007 LVDCVMVRNEITGHTYRFPCGRWLG--KGIDDGSLERILIGELMTSASDEDLVK 1058
>gi|5174633 receptor for egg jelly-like protein precursor [Homo
sapiens]
Length = 2253
Score = 60.5 bits (145), Expect = 4e-09
Identities = 35/116 (30%), Positives = 56/116 (48%), Gaps = 1/116 (0%)
Query: 114 VIDEEEMMEWTSYTVAVKTSDILGAGTDANVFIIIFGENGDSGTLALKQSANWNKFERNN 173
V+ + + + Y V + T G+GT ANVF+ + G S L ++ R +
Sbjct: 1220 VLPDNDPYDNLCYLVTIFTGSRWGSGTRANVFVQLRGTVSTSDVHCLSHP-HFTTLYRGS 1278
Query: 174 TDTFNFPDMLSLGHLCKLRVWHDNKGIFPGWHLSYVDVKDNSRDETFHFQCDCWLS 229
+TF LG + +RVWH+N+G P W+LS + V++ + F C WLS
Sbjct: 1279 INTFLLTTKSDLGDIHSIRVWHNNEGRSPSWYLSRIKVENLFSRHIWLFICQKWLS 1334
Score = 56.6 bits (135), Expect = 5e-08
Identities = 32/102 (31%), Positives = 51/102 (50%), Gaps = 1/102 (0%)
Query: 395 YEVIVTTGYEPGAGTDANVFVTIFGANGDTGKRELKQKMRNLFERGSTDRFFLETL-ELG 453
Y V + TG G+GT ANVFV + G + L RGS + F L T +LG
Sbjct: 1232 YLVTIFTGSRWGSGTRANVFVQLRGTVSTSDVHCLSHPHFTTLYRGSINTFLLTTKSDLG 1291
Query: 454 ELRKVRLEHDSSGYCSGWLVEKVEVTNTSTGVATIFNCGRWL 495
++ +R+ H++ G W + +++V N + +F C +WL
Sbjct: 1292 DIHSIRVWHNNEGRSPSWYLSRIKVENLFSRHIWLFICQKWL 1333
Score = 43.5 bits (101), Expect = 5e-04
Identities = 27/101 (26%), Positives = 50/101 (49%), Gaps = 2/101 (1%)
Query: 1 MTVWTGDVVGGGTDSNIFMTLYGINGSTEEMQLDKKK-ARFEREQNDTFIMEIL-DIAPF 58
+T++TG G GT +N+F+ L G +++ L R +TF++ D+
Sbjct: 1234 VTIFTGSRWGSGTRANVFVQLRGTVSTSDVHCLSHPHFTTLYRGSINTFLLTTKSDLGDI 1293
Query: 59 TKMRIRIDGLGSRPEWFLERILLKNMNTGDLTMFYYGDWLS 99
+R+ + G P W+L RI ++N+ + + +F WLS
Sbjct: 1294 HSIRVWHNNEGRSPSWYLSRIKVENLFSRHIWLFICQKWLS 1334
>gi|4502057 arachidonate 5-lipoxygenase [Homo sapiens]
Length = 674
Score = 51.2 bits (121), Expect = 2e-06
Identities = 33/102 (32%), Positives = 53/102 (51%), Gaps = 2/102 (1%)
Query: 395 YEVIVTTGYEPGAGTDANVFVTIFGANGDTGKRELKQKMRNLFERGSTDRFFLET-LELG 453
Y V V TG + AGTD +++++ G+ G + K L + N FERG+ D + + ELG
Sbjct: 4 YTVTVATGSQWFAGTDDYIYLSLVGSAGCSEKHLLDKPFYNDFERGAVDSYDVTVDEELG 63
Query: 454 ELRKVRLEHDSSGYCSGWLVEKVEVTNTSTGVATIFNCGRWL 495
E++ VR+E W ++ + + T G F C RW+
Sbjct: 64 EIQLVRIEKRKYWLNDDWYLKYITL-KTPHGDYIEFPCYRWI 104
Score = 43.9 bits (102), Expect = 4e-04
Identities = 32/114 (28%), Positives = 52/114 (45%), Gaps = 5/114 (4%)
Query: 125 SYTVAVKTSDILGAGTDANVFIIIFGENGDSGTLALKQSANWNKFERNNTDTFNFPDMLS 184
SYTV V T AGTD +++ + G G S L + +N FER D+++
Sbjct: 3 SYTVTVATGSQWFAGTDDYIYLSLVGSAGCSEKHLLDKPF-YNDFERGAVDSYDVTVDEE 61
Query: 185 LGHLCKLRVWHDNKGIFPGWHLSYVDVKDNSRDETFHFQCDCWLSKSEGDGQTV 238
LG + +R+ + W+L Y+ +K + F C W++ GD + V
Sbjct: 62 LGEIQLVRIEKRKYWLNDDWYLKYITLK-TPHGDYIEFPCYRWIT---GDVEVV 111
Score = 36.6 bits (83), Expect = 0.056
Identities = 30/101 (29%), Positives = 49/101 (48%), Gaps = 3/101 (2%)
Query: 1 MTVWTGDVVGGGTDSNIFMTLYGINGSTEEMQLDKKKAR-FEREQNDTFIMEI-LDIAPF 58
+TV TG GTD I+++L G G +E+ LDK FER D++ + + ++
Sbjct: 6 VTVATGSQWFAGTDDYIYLSLVGSAGCSEKHLLDKPFYNDFERGAVDSYDVTVDEELGEI 65
Query: 59 TKMRIRIDGLGSRPEWFLERILLKNMNTGDLTMFYYGDWLS 99
+RI +W+L+ I LK + GD F W++
Sbjct: 66 QLVRIEKRKYWLNDDWYLKYITLKTPH-GDYIEFPCYRWIT 105
>gi|182765464 arachidonate lipoxygenase 3 [Homo sapiens]
Length = 711
Score = 46.2 bits (108), Expect = 7e-05
Identities = 33/105 (31%), Positives = 54/105 (51%), Gaps = 5/105 (4%)
Query: 395 YEVIVTTGYEPGAGTDANVFVTIFGANGDTGKRELKQKMRNLFERGSTDRFFLE-TLELG 453
Y + VTTG AGT N+ VT+ G G++ K+ L + R+ F GS ++ + T ELG
Sbjct: 4 YRLCVTTGPYLRAGTLDNISVTLVGTCGESPKQRLDRMGRD-FAPGSVQKYKVRCTAELG 62
Query: 454 ELRKVRLEHDSSGYC--SGWLVEKVEVTNTSTGVATIFNCGRWLD 496
EL +R+ + + W ++ VT G + F C +W++
Sbjct: 63 ELLLLRVHKERYAFFRKDSWYCSRICVTEPD-GSVSHFPCYQWIE 106
Score = 32.7 bits (73), Expect = 0.81
Identities = 27/105 (25%), Positives = 40/105 (38%), Gaps = 5/105 (4%)
Query: 126 YTVAVKTSDILGAGTDANVFIIIFGENGDSGTLALKQSANWNKFERNNTDTFNFPDMLSL 185
Y + V T L AGT N+ + + G G+S L + F + + L
Sbjct: 4 YRLCVTTGPYLRAGTLDNISVTLVGTCGESPKQRLDRMG--RDFAPGSVQKYKVRCTAEL 61
Query: 186 GHLCKLRVWHDNKGIF--PGWHLSYVDVKDNSRDETFHFQCDCWL 228
G L LRV + F W+ S + V + HF C W+
Sbjct: 62 GELLLLRVHKERYAFFRKDSWYCSRICVTEPD-GSVSHFPCYQWI 105
>gi|4502053 arachidonate 12-lipoxygenase, 12R type [Homo sapiens]
Length = 701
Score = 33.5 bits (75), Expect = 0.47
Identities = 28/105 (26%), Positives = 51/105 (48%), Gaps = 5/105 (4%)
Query: 395 YEVIVTTGYEPGAGTDANVFVTIFGANGDTGKRELKQKMRNLFERGSTDRFFLE-TLELG 453
Y+V V TG + +GT ++ +TI G G++ K+ L R+ F G+ ++ ++ +LG
Sbjct: 4 YKVRVATGTDLLSGTRDSISLTIVGTQGESHKQLLNHFGRD-FATGAVGQYTVQCPQDLG 62
Query: 454 ELRKVRLEHDSSGYC--SGWLVEKVEVTNTSTGVATIFNCGRWLD 496
EL +RL + + W V++ G F +W+D
Sbjct: 63 ELIIIRLHKERYAFFPKDPWYCNYVQIC-APNGRIYHFPAYQWMD 106
Score = 32.0 bits (71), Expect = 1.4
Identities = 32/125 (25%), Positives = 48/125 (38%), Gaps = 13/125 (10%)
Query: 125 SYTVAVKTSDILGAGTDANVFIIIFGENGDSGTLALKQSANWNKFERNNTDTFNFPDMLS 184
+Y V V T L +GT ++ + I G G+S L F +
Sbjct: 3 TYKVRVATGTDLLSGTRDSISLTIVGTQGESHKQLLNHFG--RDFATGAVGQYTVQCPQD 60
Query: 185 LGHLCKLRVWHDNKGIFP--GWHLSYVDV-KDNSRDETFHFQCDCW------LSKSEGDG 235
LG L +R+ + FP W+ +YV + N R +HF W L+ E G
Sbjct: 61 LGELIIIRLHKERYAFFPKDPWYCNYVQICAPNGR--IYHFPAYQWMDGYETLALREATG 118
Query: 236 QTVRD 240
+T D
Sbjct: 119 KTTAD 123
>gi|154426292 arachidonate 12-lipoxygenase [Homo sapiens]
Length = 663
Score = 32.0 bits (71), Expect = 1.4
Identities = 27/103 (26%), Positives = 44/103 (42%), Gaps = 6/103 (5%)
Query: 394 KYEVIVTTGYEPGAGTDANVFVTIFGANGDTGKRELKQKMRNLFERGSTDRFFLETLE-L 452
+Y + V TG +G+ V + + G G+ EL+ ++R RG + F + E L
Sbjct: 3 RYRIRVATGAWLFSGSYNRVQLWLVGTRGEA---ELELQLRPA--RGEEEEFDHDVAEDL 57
Query: 453 GELRKVRLEHDSSGYCSGWLVEKVEVTNTSTGVATIFNCGRWL 495
G L+ VRL W +++ V F C RW+
Sbjct: 58 GLLQFVRLRKHHWLVDDAWFCDRITVQGPGACAEVAFPCYRWV 100
>gi|44889963 CD163 antigen isoform b [Homo sapiens]
Length = 1121
Score = 30.0 bits (66), Expect = 5.2
Identities = 14/52 (26%), Positives = 22/52 (42%), Gaps = 1/52 (1%)
Query: 457 KVRLEHDSSGYCS-GWLVEKVEVTNTSTGVATIFNCGRWLDKKRGDGLTWRD 507
+V+++ + C+ GW +E V V G T W + G G W D
Sbjct: 65 EVKVQEEWGTVCNNGWSMEAVSVICNQLGCPTAIKAPGWANSSAGSGRIWMD 116
>gi|44662834 CD163 antigen isoform a [Homo sapiens]
Length = 1156
Score = 30.0 bits (66), Expect = 5.2
Identities = 14/52 (26%), Positives = 22/52 (42%), Gaps = 1/52 (1%)
Query: 457 KVRLEHDSSGYCS-GWLVEKVEVTNTSTGVATIFNCGRWLDKKRGDGLTWRD 507
+V+++ + C+ GW +E V V G T W + G G W D
Sbjct: 65 EVKVQEEWGTVCNNGWSMEAVSVICNQLGCPTAIKAPGWANSSAGSGRIWMD 116
>gi|40316937 arachidonate 15-lipoxygenase [Homo sapiens]
Length = 662
Score = 29.6 bits (65), Expect = 6.8
Identities = 27/104 (25%), Positives = 46/104 (44%), Gaps = 8/104 (7%)
Query: 395 YEVIVTTGYEPGAGTDANVFVTIFGANGDT--GKRELKQKMRNLFERGSTDRFFLETLEL 452
Y + V+TG AG++ V + + G +G+ GKR + + + + L L
Sbjct: 4 YRIRVSTGASLYAGSNNQVQLWLVGQHGEAALGKRLWPARGKETELKVEVPEY-LGPLLF 62
Query: 453 GELRKVRLEHDSSGYCSGWLVEKVEVTNTSTGVATIFNCGRWLD 496
+LRK L D + +C+ W + V G F C RW++
Sbjct: 63 VKLRKRHLLKDDAWFCN-W----ISVQGPGAGDEVRFPCYRWVE 101
Database: hs.faa
Posted date: Aug 4, 2009 4:42 PM
Number of letters in database: 18,247,518
Number of sequences in database: 37,866
Lambda K H
0.320 0.137 0.424
Gapped
Lambda K H
0.267 0.0410 0.140
Matrix: BLOSUM62
Gap Penalties: Existence: 11, Extension: 1
Number of Hits to DB: 19,319,084
Number of Sequences: 37866
Number of extensions: 842058
Number of successful extensions: 1787
Number of sequences better than 10.0: 24
Number of HSP's better than 10.0 without gapping: 19
Number of HSP's successfully gapped in prelim test: 5
Number of HSP's that attempted gapping in prelim test: 1481
Number of HSP's gapped (non-prelim): 120
length of query: 512
length of database: 18,247,518
effective HSP length: 107
effective length of query: 405
effective length of database: 14,195,856
effective search space: 5749321680
effective search space used: 5749321680
T: 11
A: 40
X1: 16 ( 7.4 bits)
X2: 38 (14.6 bits)
X3: 64 (24.7 bits)
S1: 41 (21.8 bits)
S2: 64 (29.3 bits)
Search results were obtained with NCBI BLAST and RefSeq entries.
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Guide to the Human Genome
Copyright © 2010 by Stewart Scherer. All rights reserved.