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Search of human proteins with 224282174
BLASTP 2.2.11 [Jun-05-2005]
Reference: Altschul, Stephen F., Thomas L. Madden, Alejandro A. Schaffer,
Jinghui Zhang, Zheng Zhang, Webb Miller, and David J. Lipman (1997),
"Gapped BLAST and PSI-BLAST: a new generation of protein database search
programs", Nucleic Acids Res. 25:3389-3402.
Query= gi|224282174 DH and coiled-coil domain-containing protein [Homo
sapiens]
(844 letters)
Database: hs.faa
37,866 sequences; 18,247,518 total letters
Searching..................................................done
Score E
Sequences producing significant alignments: (bits) Value
gi|224282174 DH and coiled-coil domain-containing protein [Homo ... 1692 0.0
gi|32483416 neurofilament, heavy polypeptide 200kDa [Homo sapiens] 55 4e-07
gi|55770834 centromere protein F [Homo sapiens] 53 1e-06
gi|82546845 breakpoint cluster region isoform 2 [Homo sapiens] 52 3e-06
gi|82546843 breakpoint cluster region isoform 1 [Homo sapiens] 52 3e-06
gi|118150678 epithelial cell transforming sequence 2 oncogene-li... 51 5e-06
gi|217272804 hyaluronan-mediated motility receptor isoform d [Ho... 50 9e-06
gi|217272802 hyaluronan-mediated motility receptor isoform a [Ho... 50 9e-06
gi|217416398 hyaluronan-mediated motility receptor isoform c [Ho... 50 9e-06
gi|217416394 hyaluronan-mediated motility receptor isoform b [Ho... 50 9e-06
gi|154240686 FYVE, RhoGEF and PH domain containing 6 [Homo sapiens] 50 1e-05
gi|62548864 Rho guanine nucleotide exchange factor 10 [Homo sapi... 49 1e-05
gi|21735572 epithelial cell transforming sequence 2 oncogene pro... 48 4e-05
gi|58761492 Rho guanine nucleotide exchange factor (GEF) 10-like... 47 1e-04
gi|74136547 Rho guanine nucleotide exchange factor (GEF) 10-like... 47 1e-04
gi|24797153 faciogenital dysplasia protein [Homo sapiens] 46 2e-04
gi|134133248 FYVE, RhoGEF and PH domain containing 3 [Homo sapiens] 46 2e-04
gi|134133265 FYVE, RhoGEF and PH domain containing 3 [Homo sapiens] 46 2e-04
gi|45439359 triple functional domain (PTPRF interacting) [Homo s... 45 2e-04
gi|21361458 Rho guanine nucleotide exchange factor (GEF) 17 [Hom... 45 3e-04
gi|58530876 melanoma antigen family C, 1 [Homo sapiens] 44 5e-04
gi|22538387 A-kinase anchor protein 9 isoform 2 [Homo sapiens] 44 6e-04
gi|39930351 dynamin binding protein [Homo sapiens] 43 0.001
gi|31982906 cingulin-like 1 [Homo sapiens] 42 0.002
gi|38683807 ankyrin repeat domain protein 17 isoform a [Homo sap... 42 0.002
gi|229094128 active breakpoint cluster region-related protein i... 42 0.003
gi|38679957 active breakpoint cluster region-related protein is... 42 0.003
gi|38679954 active breakpoint cluster region-related protein is... 42 0.003
gi|157738615 coiled-coil alpha-helical rod protein 1 isoform 1 [... 41 0.004
gi|157738613 coiled-coil alpha-helical rod protein 1 isoform 2 [... 41 0.004
>gi|224282174 DH and coiled-coil domain-containing protein [Homo
sapiens]
Length = 844
Score = 1692 bits (4383), Expect = 0.0
Identities = 844/844 (100%), Positives = 844/844 (100%)
Query: 1 MEKTKTKQGENEHMPVNNPSTQIYQLQALASELKTGFTEAMQELSRIQHGEYALEEKVKS 60
MEKTKTKQGENEHMPVNNPSTQIYQLQALASELKTGFTEAMQELSRIQHGEYALEEKVKS
Sbjct: 1 MEKTKTKQGENEHMPVNNPSTQIYQLQALASELKTGFTEAMQELSRIQHGEYALEEKVKS 60
Query: 61 CRCSMEEKVTEMKNSLNYFKEELSNAMSMIQAITSKQEEMQQKIEQLQQEKRRESRKVKA 120
CRCSMEEKVTEMKNSLNYFKEELSNAMSMIQAITSKQEEMQQKIEQLQQEKRRESRKVKA
Sbjct: 61 CRCSMEEKVTEMKNSLNYFKEELSNAMSMIQAITSKQEEMQQKIEQLQQEKRRESRKVKA 120
Query: 121 KKTQKEEHSSQAGPAQAQGSPFRSINIPEPVLPSEDFTNLLPSQAYEKAQESRSVHVGDS 180
KKTQKEEHSSQAGPAQAQGSPFRSINIPEPVLPSEDFTNLLPSQAYEKAQESRSVHVGDS
Sbjct: 121 KKTQKEEHSSQAGPAQAQGSPFRSINIPEPVLPSEDFTNLLPSQAYEKAQESRSVHVGDS 180
Query: 181 NVKGMMGPGVNPTTPEAEENLKSCLSADIQSKGHLPSGMWRQPKDGKEWGEEYVTKDHPD 240
NVKGMMGPGVNPTTPEAEENLKSCLSADIQSKGHLPSGMWRQPKDGKEWGEEYVTKDHPD
Sbjct: 181 NVKGMMGPGVNPTTPEAEENLKSCLSADIQSKGHLPSGMWRQPKDGKEWGEEYVTKDHPD 240
Query: 241 KLKEAGQGRHSSLENVLCETSLAAKRQTVALELLESERKYVINISLILKIKATFQGSDGK 300
KLKEAGQGRHSSLENVLCETSLAAKRQTVALELLESERKYVINISLILKIKATFQGSDGK
Sbjct: 241 KLKEAGQGRHSSLENVLCETSLAAKRQTVALELLESERKYVINISLILKIKATFQGSDGK 300
Query: 301 RNSKERSLFPGSLRYLVQQHLDLLHALQERVLKWPRQGVLGDLFLKLTNDENNFLDYYVA 360
RNSKERSLFPGSLRYLVQQHLDLLHALQERVLKWPRQGVLGDLFLKLTNDENNFLDYYVA
Sbjct: 301 RNSKERSLFPGSLRYLVQQHLDLLHALQERVLKWPRQGVLGDLFLKLTNDENNFLDYYVA 360
Query: 361 YLRDLPECISLVHVVVLKEGDEEIKSDIYTLFFHIVQRIPEYLIHLQNVLKFTEQEHPDY 420
YLRDLPECISLVHVVVLKEGDEEIKSDIYTLFFHIVQRIPEYLIHLQNVLKFTEQEHPDY
Sbjct: 361 YLRDLPECISLVHVVVLKEGDEEIKSDIYTLFFHIVQRIPEYLIHLQNVLKFTEQEHPDY 420
Query: 421 YLLLVCVQRLRVFISHYTLLFQCNEDLLIQKRKKLKKSSMAKLYKGLASQCANAGQDASP 480
YLLLVCVQRLRVFISHYTLLFQCNEDLLIQKRKKLKKSSMAKLYKGLASQCANAGQDASP
Sbjct: 421 YLLLVCVQRLRVFISHYTLLFQCNEDLLIQKRKKLKKSSMAKLYKGLASQCANAGQDASP 480
Query: 481 TAGPEAVRDTGIHSEELLQPYPSAPSSGPAITHLMPPVKKSQQQQSLMESMQPGKPSDWE 540
TAGPEAVRDTGIHSEELLQPYPSAPSSGPAITHLMPPVKKSQQQQSLMESMQPGKPSDWE
Sbjct: 481 TAGPEAVRDTGIHSEELLQPYPSAPSSGPAITHLMPPVKKSQQQQSLMESMQPGKPSDWE 540
Query: 541 LEGRKHERPESLLAPTQFCAAEQDVKALAGPLQAIPEMDFESSPAEPLGNVERSLRAPAE 600
LEGRKHERPESLLAPTQFCAAEQDVKALAGPLQAIPEMDFESSPAEPLGNVERSLRAPAE
Sbjct: 541 LEGRKHERPESLLAPTQFCAAEQDVKALAGPLQAIPEMDFESSPAEPLGNVERSLRAPAE 600
Query: 601 LLPDARGFVPAAYEEFEYGGEIFALPAPYDEEPFQAPALFENCSPASSESSLDICFLRPV 660
LLPDARGFVPAAYEEFEYGGEIFALPAPYDEEPFQAPALFENCSPASSESSLDICFLRPV
Sbjct: 601 LLPDARGFVPAAYEEFEYGGEIFALPAPYDEEPFQAPALFENCSPASSESSLDICFLRPV 660
Query: 661 SFAMEAERPEHPLQPLPKSATSPAGSSSAYKLEAAAQAHGKAKPLSRSLKEFPRAPPADG 720
SFAMEAERPEHPLQPLPKSATSPAGSSSAYKLEAAAQAHGKAKPLSRSLKEFPRAPPADG
Sbjct: 661 SFAMEAERPEHPLQPLPKSATSPAGSSSAYKLEAAAQAHGKAKPLSRSLKEFPRAPPADG 720
Query: 721 VAPRLYSTRSSSGGRAPIKAERAAQAHGPAAAAVAARGASRTFFPQQRSQSEKQTYLEVR 780
VAPRLYSTRSSSGGRAPIKAERAAQAHGPAAAAVAARGASRTFFPQQRSQSEKQTYLEVR
Sbjct: 721 VAPRLYSTRSSSGGRAPIKAERAAQAHGPAAAAVAARGASRTFFPQQRSQSEKQTYLEVR 780
Query: 781 REMHLEDTTRFCPKEERESEQTSFSDQNPRQDQKGGFRSSFRKLFKKKNGNATGEDFCGP 840
REMHLEDTTRFCPKEERESEQTSFSDQNPRQDQKGGFRSSFRKLFKKKNGNATGEDFCGP
Sbjct: 781 REMHLEDTTRFCPKEERESEQTSFSDQNPRQDQKGGFRSSFRKLFKKKNGNATGEDFCGP 840
Query: 841 WGWW 844
WGWW
Sbjct: 841 WGWW 844
>gi|32483416 neurofilament, heavy polypeptide 200kDa [Homo sapiens]
Length = 1020
Score = 54.7 bits (130), Expect = 4e-07
Identities = 63/295 (21%), Positives = 120/295 (40%), Gaps = 23/295 (7%)
Query: 519 KKSQQQQSLMESMQPGKPSDWELEGRKHERPESLLAPTQFCAAEQDVKALAGPLQAIPEM 578
+++++ Q E + + E EG++ E E A E++ K+ A PE
Sbjct: 459 EQTEETQVTEEVTEEEEKEAKEEEGKEEEGGEEEEAE----GGEEETKSPPAEEAASPEK 514
Query: 579 DFES-------SPAEPLGNVERSLRAPAELLPDARGFVPAAYEEFEYGGEIFALPAPYDE 631
+ +S SPAE + ++PAE+ + PA EE + E + +
Sbjct: 515 EAKSPVKEEAKSPAEAKSPEKEEAKSPAEVKSPEKAKSPAK-EEAKSPPEAKSPEKEEAK 573
Query: 632 EPFQAPALFENCSPASSESSLDICFLRPVSFAMEAERPEHPLQPLPKSATSPAGSSSAYK 691
P + + + SPA E+ EA+ PE P+ + A SPA + S K
Sbjct: 574 SPAEVKSPEKAKSPAKEEAKSPA----------EAKSPEKAKSPVKEEAKSPAEAKSPVK 623
Query: 692 LEAAAQAHGKAKPLSRSLKEFPRAPPADGVAPRLYSTRSSSGGRAPIKAERAAQAHGPAA 751
EA + A K+ ++S + P +P +S ++P+KAE + +
Sbjct: 624 EEAKSPAEVKSPEKAKSPTKEEAKSPEKAKSPEKEEAKSPEKAKSPVKAEAKSPEKAKSP 683
Query: 752 AAVAARGASRTFFP-QQRSQSEKQTYLEVRREMHLEDTTRFCPKEERESEQTSFS 805
A+ + P ++ ++S ++ V+ E + + KEE ++ + + S
Sbjct: 684 VKAEAKSPEKAKSPVKEEAKSPEKAKSPVKEEAKSPEKAKSPVKEEAKTPEKAKS 738
>gi|55770834 centromere protein F [Homo sapiens]
Length = 3114
Score = 53.1 bits (126), Expect = 1e-06
Identities = 62/291 (21%), Positives = 118/291 (40%), Gaps = 18/291 (6%)
Query: 1 MEKTKTKQGENEHMPVNNPSTQIYQLQALASELKTGFTEAMQELSRIQHGEYALEEKVKS 60
+EK K + E E + +N ++ + A + T +T Q+L ++ + +S
Sbjct: 322 LEKAKVELIEKEKV-LNKCRDELVRTTAQYDQASTKYTALEQKLKKLTEDLSCQRQNAES 380
Query: 61 CRCSMEEKVTEMKNSLNYFKEELSNAMSMIQAITSKQEEMQQKI-EQLQQEK------RR 113
RCS+E+K+ E + F+EELS Q + + +M+ ++ ++LQQ K +
Sbjct: 381 ARCSLEQKIKEKEKE---FQEELSRQQRSFQTLDQECIQMKARLTQELQQAKNMHNVLQA 437
Query: 114 ESRKVKAKKTQKEEHSSQ------AGPAQAQGSPFRSINIPEPVLPSEDFTNLLPSQAYE 167
E K+ + K Q E + + Q S + + + + NLL S + +
Sbjct: 438 ELDKLTSVKQQLENNLEEFKQKLCRAEQAFQASQIKENELRRSMEEMKKENNLLKSHSEQ 497
Query: 168 KAQESRSVHVGDSNVKGMMGPGVN-PTTPEAEENLKSCLSADIQSKGHLPSGMWRQPKDG 226
KA+E + N+K + N +A+ + + D+Q K + K
Sbjct: 498 KAREVCHLEAELKNIKQCLNQSQNFAEEMKAKNTSQETMLRDLQEKINQQENSLTLEKLK 557
Query: 227 KEWGEEYVTKDHPDKLKEAGQGRHSSLENVLCETSLAAKRQTVALELLESE 277
+ +D L + + L + L +T +K ALEL + E
Sbjct: 558 LAVADLEKQRDCSQDLLKKREHHIEQLNDKLSKTEKESKALLSALELKKKE 608
Score = 36.2 bits (82), Expect = 0.13
Identities = 51/204 (25%), Positives = 82/204 (40%), Gaps = 31/204 (15%)
Query: 42 QELSRIQHGEYALEEKVKSCRCSMEEKVTEMKNSLNYFKEELSNAMSMIQAITSKQEEMQ 101
+ELS++Q A +EK K+ M+ KV E+ + KE L T + +E
Sbjct: 2814 KELSQLQ----AAQEKQKTGTV-MDTKVDELTTEIKELKETLEEK-------TKEADEYL 2861
Query: 102 QKIEQLQQEKRRESRKVKAKKTQKEEHSSQAGPAQAQGSPFRSINIPEP-VLPSEDFTNL 160
K L + + + +TQ SQ ++GSP +P P +PS L
Sbjct: 2862 DKYCSLLISHEKLEKAKEMLETQVAHLCSQQSKQDSRGSPLLGPVVPGPSPIPSVTEKRL 2921
Query: 161 LPSQAYEKAQESRSVHVGDSNVKGMMGPGVNPTTPEAEENLKSCLSADIQSKGHLPSGMW 220
Q + RS + ++ G G P TPE S +SK + SG+
Sbjct: 2922 SSGQNKASGKRQRSSGIWEN------GRGPTPATPE---------SFSKKSKKAVMSGI- 2965
Query: 221 RQPKDGKEWGEEYVTKDHPDKLKE 244
P + E G E+ + P+ +K+
Sbjct: 2966 -HPAEDTE-GTEFEPEGLPEVVKK 2987
Score = 32.7 bits (73), Expect = 1.4
Identities = 21/91 (23%), Positives = 41/91 (45%), Gaps = 1/91 (1%)
Query: 32 ELKTGFTEAMQE-LSRIQHGEYALEEKVKSCRCSMEEKVTEMKNSLNYFKEELSNAMSMI 90
+LK F + QE L+++ E + + + +EM ++ N K E I
Sbjct: 1073 QLKEAFAKEHQEFLTKLAFAEERNQNLMLELETVQQALRSEMTDNQNNSKSEAGGLKQEI 1132
Query: 91 QAITSKQEEMQQKIEQLQQEKRRESRKVKAK 121
+ +Q +MQ+++ L QE + + +K K
Sbjct: 1133 MTLKEEQNKMQKEVNDLLQENEQLMKVMKTK 1163
Score = 32.7 bits (73), Expect = 1.4
Identities = 29/116 (25%), Positives = 60/116 (51%), Gaps = 7/116 (6%)
Query: 16 VNNPSTQIYQLQALASELKTGFTEAMQE--LSRIQHGEYALEEKVKSCRCSMEEKVTEMK 73
++ +T + QL E KT E+ Q L IQ E ++EK + + ++ V+E+
Sbjct: 1970 MSKKTTALDQLSEKMKE-KTQELESHQSECLHCIQVAEAEVKEKTELLQ-TLSSDVSELL 2027
Query: 74 NSLNYFKEELSNAMSMIQAITSKQEEMQQKIEQLQQEKR---RESRKVKAKKTQKE 126
+ +E+L + QA++ + E++ +I QL +EK +ES ++A+ ++ +
Sbjct: 2028 KDKTHLQEKLQSLEKDSQALSLTKCELENQIAQLNKEKELLVKESESLQARLSESD 2083
Score = 32.0 bits (71), Expect = 2.5
Identities = 24/121 (19%), Positives = 59/121 (48%), Gaps = 14/121 (11%)
Query: 4 TKTKQGENEHMPVNNPSTQIYQLQALASELKTGFTEAMQELSRIQHGEYALEEKVKSCRC 63
+K Q E EH Q+++ Q L EL+ E Q++ +Q +L++ ++ +
Sbjct: 2539 SKLSQVEGEH--------QLWKEQNL--ELRNLTVELEQKIQVLQSKNASLQDTLEVLQS 2588
Query: 64 SMEEKVTEMKNSLNYFKEELSNAMSMIQAITSKQEEMQQKIEQLQQEKRRESRKVKAKKT 123
S + ++N L K + + + + +T+K+ E+Q+++ ++ Q+ ++ +K
Sbjct: 2589 SYKN----LENELELTKMDKMSFVEKVNKMTAKETELQREMHEMAQKTAELQEELSGEKN 2644
Query: 124 Q 124
+
Sbjct: 2645 R 2645
Score = 30.0 bits (66), Expect = 9.4
Identities = 22/94 (23%), Positives = 42/94 (44%), Gaps = 9/94 (9%)
Query: 52 YALEEKVKSCRCSMEEKVTEMKNSLNYFKEELSNAMSMIQAITSKQEEMQQKIEQLQQE- 110
+ALEE + +K+ E++ L+ K+E + ++ + ++ +QK+E + E
Sbjct: 3 WALEEWKEGLPTRALQKIQELEGQLDKLKKEKQQRQFQLDSLEAALQKQKQKVENEKTEG 62
Query: 111 ---KRRESRKVK-----AKKTQKEEHSSQAGPAQ 136
KR R ++ K QK H Q +Q
Sbjct: 63 TNLKRENQRLMEICESLEKTKQKISHELQVKESQ 96
>gi|82546845 breakpoint cluster region isoform 2 [Homo sapiens]
Length = 1227
Score = 51.6 bits (122), Expect = 3e-06
Identities = 60/256 (23%), Positives = 106/256 (41%), Gaps = 31/256 (12%)
Query: 242 LKEAGQGRHSSLENVLCETSLAAK---------RQTVALELLESERKYVINISLIL---- 288
L G+G +L + E++ A++ R+ V +L SE Y+ ++ +L
Sbjct: 466 LSSKGRGSRDALVSGALESTKASELDLEKGLEMRKWVLSGILASEETYLSHLEALLLPMK 525
Query: 289 KIKATFQGSDGKRNSKERSLFPGSLRYLVQQHLDLLHALQERVLKWPRQGVLGDLFLKLT 348
+KA S S++ + L + H + L RV +W Q +GDLF KL
Sbjct: 526 PLKAAATTSQPVLTSQQIETIFFKVPELYEIHKEFYDGLFPRVQQWSHQQRVGDLFQKLA 585
Query: 349 ND---ENNFLDYYVAYLRDLPECISL-VHVVVLKEG----------DEEIKSDIYTLFFH 394
+ F+D Y + +C + E D K+ + TL +
Sbjct: 586 SQLGVYRAFVDNYGVAMEMAEKCCQANAQFAEISENLRARSNKDAKDPTTKNSLETLLYK 645
Query: 395 IVQRIPEYLIHLQNVLKFTEQEHPDYYLLLVCVQRLRVFISHYT-LLFQCNEDLLIQK-- 451
V R+ + L ++LK T HPD+ LL ++ + F+S + + + ++K
Sbjct: 646 PVDRVTRSTLVLHDLLKHTPASHPDHPLLQDALRISQNFLSSINEEITPRRQSMTVKKGE 705
Query: 452 -RKKLKKSSMAKLYKG 466
R+ LK S M +L +G
Sbjct: 706 HRQLLKDSFMVELVEG 721
>gi|82546843 breakpoint cluster region isoform 1 [Homo sapiens]
Length = 1271
Score = 51.6 bits (122), Expect = 3e-06
Identities = 60/256 (23%), Positives = 106/256 (41%), Gaps = 31/256 (12%)
Query: 242 LKEAGQGRHSSLENVLCETSLAAK---------RQTVALELLESERKYVINISLIL---- 288
L G+G +L + E++ A++ R+ V +L SE Y+ ++ +L
Sbjct: 466 LSSKGRGSRDALVSGALESTKASELDLEKGLEMRKWVLSGILASEETYLSHLEALLLPMK 525
Query: 289 KIKATFQGSDGKRNSKERSLFPGSLRYLVQQHLDLLHALQERVLKWPRQGVLGDLFLKLT 348
+KA S S++ + L + H + L RV +W Q +GDLF KL
Sbjct: 526 PLKAAATTSQPVLTSQQIETIFFKVPELYEIHKEFYDGLFPRVQQWSHQQRVGDLFQKLA 585
Query: 349 ND---ENNFLDYYVAYLRDLPECISL-VHVVVLKEG----------DEEIKSDIYTLFFH 394
+ F+D Y + +C + E D K+ + TL +
Sbjct: 586 SQLGVYRAFVDNYGVAMEMAEKCCQANAQFAEISENLRARSNKDAKDPTTKNSLETLLYK 645
Query: 395 IVQRIPEYLIHLQNVLKFTEQEHPDYYLLLVCVQRLRVFISHYT-LLFQCNEDLLIQK-- 451
V R+ + L ++LK T HPD+ LL ++ + F+S + + + ++K
Sbjct: 646 PVDRVTRSTLVLHDLLKHTPASHPDHPLLQDALRISQNFLSSINEEITPRRQSMTVKKGE 705
Query: 452 -RKKLKKSSMAKLYKG 466
R+ LK S M +L +G
Sbjct: 706 HRQLLKDSFMVELVEG 721
>gi|118150678 epithelial cell transforming sequence 2 oncogene-like
[Homo sapiens]
Length = 904
Score = 50.8 bits (120), Expect = 5e-06
Identities = 47/195 (24%), Positives = 87/195 (44%), Gaps = 14/195 (7%)
Query: 252 SLENVLCETSLAAKRQTVALELLESERKYVINISL-----ILKIKATFQGSDGKRNSKER 306
+LE +L + S A KR V ELL+SERKYV + + + +KA + ++
Sbjct: 554 NLERILQKDS-AEKRARVVRELLQSERKYVQILEIVRDVYVAPLKAALSSNRAILSAANI 612
Query: 307 SLFPGSLRYLVQQHLDLLHALQERVLKWPRQGVLGDLFLKL---TNDENNFLDYYVAYLR 363
+ + ++ + L L++R+ +W +G++ K N NF + Y L+
Sbjct: 613 QIIFCDILQILSLNRQFLDNLRDRLQEWGPAHCVGEIVTKFGSQLNTYTNFFNNYPVILK 672
Query: 364 DLPECISLVHV--VVLKEGDEEIKSDIYT---LFFHIVQRIPEYLIHLQNVLKFTEQEHP 418
+ +C ++ LK D+ I + + + L + +R EYL L V T EH
Sbjct: 673 TIEKCREMIPAFRTFLKRHDKTIVTKMLSLPELLLYPSRRFEEYLNLLYAVRLHTPAEHV 732
Query: 419 DYYLLLVCVQRLRVF 433
D L + +++ +
Sbjct: 733 DRGDLTTAIDQIKKY 747
>gi|217272804 hyaluronan-mediated motility receptor isoform d [Homo
sapiens]
Length = 638
Score = 50.1 bits (118), Expect = 9e-06
Identities = 83/398 (20%), Positives = 155/398 (38%), Gaps = 65/398 (16%)
Query: 16 VNNPSTQIYQLQALASELKTGFTEAMQELSRIQHGEYALE---EKVKSCRCSMEEKVT-- 70
VN L A LK F QE ++Q E ++ ++ K S+ +K+
Sbjct: 218 VNRNREHNENLNAEMQNLKQKFILEQQEREKLQQKELQIDSLLQQEKELSSSLHQKLCSF 277
Query: 71 --EMKNSLNYFKEELSNAMSMIQAITSKQEEMQQKIEQLQQEKRRESRKVK---AKKTQK 125
EM N F+EEL + + + K+E+ ++ ++QL++E + + ++K K K
Sbjct: 278 QEEMVKEKNLFEEELKQTLDELDKLQQKEEQAERLVKQLEEEAKSRAEELKLLEEKLKGK 337
Query: 126 EEHSSQAGPAQAQGSPFRSINIPEPVLPSEDFTNLLPSQAYEKAQESRSVHVGDSNVKGM 185
E ++ A Q + V ED T S A E + + +S+++
Sbjct: 338 EAELEKSSAAHTQATLLLQEKYDSMVQSLEDVTAQFESYKALTASEIEDLKLENSSLQEK 397
Query: 186 MGPG----------VNPTTPEAEENLKSCLSADIQSKGHLPSGMWRQPKDGKEWGEEYVT 235
+ T +E ++ L D+Q+K L + + KE ++
Sbjct: 398 AAKAGKNAEDVQHQILATESSNQEYVRMLL--DLQTKSAL------KETEIKEITVSFLQ 449
Query: 236 K--DHPDKLKEAGQGRHSSLENVLCETSLAAKRQTVALELLESERKYVINISLILKIKAT 293
K D ++LK+ + LE+ E A+++ EL E K+ + +
Sbjct: 450 KITDLQNQLKQQEEDFRKQLED---EEGRKAEKENTTAELTEEINKWRLLYEELYNKTKP 506
Query: 294 FQGSDGKRNSKERSLFPGSLRYLVQQHLDLLHALQERVLKWPRQGVLGDLFLKLTNDENN 353
FQ + F + L+ +H A QE++ K + D + KL +N
Sbjct: 507 FQ--------LQLDAFEVEKQALLNEH----GAAQEQLNK------IRDSYAKLLGHQN- 547
Query: 354 FLDYYVAYLRDLPECISLVHVVVLKEGDEEIKSDIYTL 391
L+ + HVV LK+ + ++KS++ L
Sbjct: 548 --------LKQ-----KIKHVVKLKDENSQLKSEVSKL 572
>gi|217272802 hyaluronan-mediated motility receptor isoform a [Homo
sapiens]
Length = 725
Score = 50.1 bits (118), Expect = 9e-06
Identities = 83/398 (20%), Positives = 155/398 (38%), Gaps = 65/398 (16%)
Query: 16 VNNPSTQIYQLQALASELKTGFTEAMQELSRIQHGEYALE---EKVKSCRCSMEEKVT-- 70
VN L A LK F QE ++Q E ++ ++ K S+ +K+
Sbjct: 305 VNRNREHNENLNAEMQNLKQKFILEQQEREKLQQKELQIDSLLQQEKELSSSLHQKLCSF 364
Query: 71 --EMKNSLNYFKEELSNAMSMIQAITSKQEEMQQKIEQLQQEKRRESRKVK---AKKTQK 125
EM N F+EEL + + + K+E+ ++ ++QL++E + + ++K K K
Sbjct: 365 QEEMVKEKNLFEEELKQTLDELDKLQQKEEQAERLVKQLEEEAKSRAEELKLLEEKLKGK 424
Query: 126 EEHSSQAGPAQAQGSPFRSINIPEPVLPSEDFTNLLPSQAYEKAQESRSVHVGDSNVKGM 185
E ++ A Q + V ED T S A E + + +S+++
Sbjct: 425 EAELEKSSAAHTQATLLLQEKYDSMVQSLEDVTAQFESYKALTASEIEDLKLENSSLQEK 484
Query: 186 MGPG----------VNPTTPEAEENLKSCLSADIQSKGHLPSGMWRQPKDGKEWGEEYVT 235
+ T +E ++ L D+Q+K L + + KE ++
Sbjct: 485 AAKAGKNAEDVQHQILATESSNQEYVRMLL--DLQTKSAL------KETEIKEITVSFLQ 536
Query: 236 K--DHPDKLKEAGQGRHSSLENVLCETSLAAKRQTVALELLESERKYVINISLILKIKAT 293
K D ++LK+ + LE+ E A+++ EL E K+ + +
Sbjct: 537 KITDLQNQLKQQEEDFRKQLED---EEGRKAEKENTTAELTEEINKWRLLYEELYNKTKP 593
Query: 294 FQGSDGKRNSKERSLFPGSLRYLVQQHLDLLHALQERVLKWPRQGVLGDLFLKLTNDENN 353
FQ + F + L+ +H A QE++ K + D + KL +N
Sbjct: 594 FQ--------LQLDAFEVEKQALLNEH----GAAQEQLNK------IRDSYAKLLGHQN- 634
Query: 354 FLDYYVAYLRDLPECISLVHVVVLKEGDEEIKSDIYTL 391
L+ + HVV LK+ + ++KS++ L
Sbjct: 635 --------LKQ-----KIKHVVKLKDENSQLKSEVSKL 659
>gi|217416398 hyaluronan-mediated motility receptor isoform c [Homo
sapiens]
Length = 709
Score = 50.1 bits (118), Expect = 9e-06
Identities = 83/398 (20%), Positives = 155/398 (38%), Gaps = 65/398 (16%)
Query: 16 VNNPSTQIYQLQALASELKTGFTEAMQELSRIQHGEYALE---EKVKSCRCSMEEKVT-- 70
VN L A LK F QE ++Q E ++ ++ K S+ +K+
Sbjct: 289 VNRNREHNENLNAEMQNLKQKFILEQQEREKLQQKELQIDSLLQQEKELSSSLHQKLCSF 348
Query: 71 --EMKNSLNYFKEELSNAMSMIQAITSKQEEMQQKIEQLQQEKRRESRKVK---AKKTQK 125
EM N F+EEL + + + K+E+ ++ ++QL++E + + ++K K K
Sbjct: 349 QEEMVKEKNLFEEELKQTLDELDKLQQKEEQAERLVKQLEEEAKSRAEELKLLEEKLKGK 408
Query: 126 EEHSSQAGPAQAQGSPFRSINIPEPVLPSEDFTNLLPSQAYEKAQESRSVHVGDSNVKGM 185
E ++ A Q + V ED T S A E + + +S+++
Sbjct: 409 EAELEKSSAAHTQATLLLQEKYDSMVQSLEDVTAQFESYKALTASEIEDLKLENSSLQEK 468
Query: 186 MGPG----------VNPTTPEAEENLKSCLSADIQSKGHLPSGMWRQPKDGKEWGEEYVT 235
+ T +E ++ L D+Q+K L + + KE ++
Sbjct: 469 AAKAGKNAEDVQHQILATESSNQEYVRMLL--DLQTKSAL------KETEIKEITVSFLQ 520
Query: 236 K--DHPDKLKEAGQGRHSSLENVLCETSLAAKRQTVALELLESERKYVINISLILKIKAT 293
K D ++LK+ + LE+ E A+++ EL E K+ + +
Sbjct: 521 KITDLQNQLKQQEEDFRKQLED---EEGRKAEKENTTAELTEEINKWRLLYEELYNKTKP 577
Query: 294 FQGSDGKRNSKERSLFPGSLRYLVQQHLDLLHALQERVLKWPRQGVLGDLFLKLTNDENN 353
FQ + F + L+ +H A QE++ K + D + KL +N
Sbjct: 578 FQ--------LQLDAFEVEKQALLNEH----GAAQEQLNK------IRDSYAKLLGHQN- 618
Query: 354 FLDYYVAYLRDLPECISLVHVVVLKEGDEEIKSDIYTL 391
L+ + HVV LK+ + ++KS++ L
Sbjct: 619 --------LKQ-----KIKHVVKLKDENSQLKSEVSKL 643
>gi|217416394 hyaluronan-mediated motility receptor isoform b [Homo
sapiens]
Length = 724
Score = 50.1 bits (118), Expect = 9e-06
Identities = 83/398 (20%), Positives = 155/398 (38%), Gaps = 65/398 (16%)
Query: 16 VNNPSTQIYQLQALASELKTGFTEAMQELSRIQHGEYALE---EKVKSCRCSMEEKVT-- 70
VN L A LK F QE ++Q E ++ ++ K S+ +K+
Sbjct: 304 VNRNREHNENLNAEMQNLKQKFILEQQEREKLQQKELQIDSLLQQEKELSSSLHQKLCSF 363
Query: 71 --EMKNSLNYFKEELSNAMSMIQAITSKQEEMQQKIEQLQQEKRRESRKVK---AKKTQK 125
EM N F+EEL + + + K+E+ ++ ++QL++E + + ++K K K
Sbjct: 364 QEEMVKEKNLFEEELKQTLDELDKLQQKEEQAERLVKQLEEEAKSRAEELKLLEEKLKGK 423
Query: 126 EEHSSQAGPAQAQGSPFRSINIPEPVLPSEDFTNLLPSQAYEKAQESRSVHVGDSNVKGM 185
E ++ A Q + V ED T S A E + + +S+++
Sbjct: 424 EAELEKSSAAHTQATLLLQEKYDSMVQSLEDVTAQFESYKALTASEIEDLKLENSSLQEK 483
Query: 186 MGPG----------VNPTTPEAEENLKSCLSADIQSKGHLPSGMWRQPKDGKEWGEEYVT 235
+ T +E ++ L D+Q+K L + + KE ++
Sbjct: 484 AAKAGKNAEDVQHQILATESSNQEYVRMLL--DLQTKSAL------KETEIKEITVSFLQ 535
Query: 236 K--DHPDKLKEAGQGRHSSLENVLCETSLAAKRQTVALELLESERKYVINISLILKIKAT 293
K D ++LK+ + LE+ E A+++ EL E K+ + +
Sbjct: 536 KITDLQNQLKQQEEDFRKQLED---EEGRKAEKENTTAELTEEINKWRLLYEELYNKTKP 592
Query: 294 FQGSDGKRNSKERSLFPGSLRYLVQQHLDLLHALQERVLKWPRQGVLGDLFLKLTNDENN 353
FQ + F + L+ +H A QE++ K + D + KL +N
Sbjct: 593 FQ--------LQLDAFEVEKQALLNEH----GAAQEQLNK------IRDSYAKLLGHQN- 633
Query: 354 FLDYYVAYLRDLPECISLVHVVVLKEGDEEIKSDIYTL 391
L+ + HVV LK+ + ++KS++ L
Sbjct: 634 --------LKQ-----KIKHVVKLKDENSQLKSEVSKL 658
>gi|154240686 FYVE, RhoGEF and PH domain containing 6 [Homo sapiens]
Length = 1430
Score = 49.7 bits (117), Expect = 1e-05
Identities = 94/438 (21%), Positives = 173/438 (39%), Gaps = 79/438 (18%)
Query: 54 LEEKVKSCRCSMEE----KVTEMKNSLNYFKEELSNAMSMIQAI---------TSKQEEM 100
+E+ K C+ S ++ K+ MK S+ + K + S + + +Q+ +
Sbjct: 611 VEKCTKPCKDSTKKNSFKKLLSMKLSICFMKSDFQKFWSKSSQLGDTTTGHLSSGEQKGI 670
Query: 101 QQKIEQLQQEKRRESRKVKAKKTQKEEHSSQAGPAQAQGSP-----FRSINIPEPVLPSE 155
+ + L + + S+ +KA T+ SQ +++G R+ ++ + +L E
Sbjct: 671 ESDWQGLLVGEEKRSKPIKAYSTENYSLESQKKRKKSRGQTSAANGLRAESLDDQMLSRE 730
Query: 156 ----------------------------DFTNLLPSQAYEKAQE-----SRSVHVGDSNV 182
++ NL A K QE S S+ D+NV
Sbjct: 731 SSSQAPYKSVTSLCAPEYENIRHYEEIPEYENLPFIMAIRKTQELEWQNSSSMEDADANV 790
Query: 183 KGMMGPGVNPTTPEAEENLKSCLSADIQSKGHLPSGMWRQPKDGKEWGEEYVTKDHPDKL 242
+ P P S+ + G+ P D +E + D D
Sbjct: 791 YEVEEPYEAPDGQLQLGPRHQHSSSGASQEEQNDLGLGDLPSDEEEIIN---SSDEDDVS 847
Query: 243 KEAGQGRHSSLENVLCETS-LAAKRQTVALELLESERKYVINISLI----LKIKATFQGS 297
E+ +G LE+ E + + +K +A E++ SE+ +V + L+ A
Sbjct: 848 SESSKGEPDPLEDKQDEDNGMKSKVHHIAKEIMSSEKVFVDVLKLLHIDFRDAVAHASRQ 907
Query: 298 DGKRNSKERSLFPGSLRYLVQQH---LDLLHALQERVLKWPRQGVLGDLFLKLTNDENNF 354
GK ++R L L YL Q + DLL L+ER+L W Q + D+F+K + +
Sbjct: 908 LGKPVIEDRILNQ-ILYYLPQLYELNRDLLKELEERMLHWTEQQRIADIFVK----KGPY 962
Query: 355 LDYYVAYLRDLPECISLV---------HVVVLKEGDEEIKSDIYTLFFHI---VQRIPEY 402
L Y Y+++ + I+L+ V++E + + L ++ VQRIP+Y
Sbjct: 963 LKMYSTYIKEFDKNIALLDEQCKKNPGFAAVVREFEMSPRCANLALKHYLLKPVQRIPQY 1022
Query: 403 LIHLQNVLKFTEQEHPDY 420
+ L + LK ++ DY
Sbjct: 1023 RLLLTDYLKNLIEDAGDY 1040
>gi|62548864 Rho guanine nucleotide exchange factor 10 [Homo
sapiens]
Length = 1344
Score = 49.3 bits (116), Expect = 1e-05
Identities = 51/221 (23%), Positives = 101/221 (45%), Gaps = 24/221 (10%)
Query: 266 RQTVALELLESERKYVINISLILKIKATFQGSDGKRNSKERSLFPGSLRY--LVQQHLDL 323
R+ + +++SE+ YV + IL+ + ER L R ++Q H
Sbjct: 397 RRYILGSVVDSEKNYVDALKRILEQYEKPLSEMEPKVLSERKLKTVFYRVKEILQCHSLF 456
Query: 324 LHALQERVLKWPRQGVLGDLFLKLTNDENNFLDYYVAYLRDLPECISLVH---------V 374
AL RV +W ++GD+F+ + ++ LD Y Y+ + ++++ +
Sbjct: 457 QIALASRVSEWDSVEMIGDVFVA-SFSKSMVLDAYSEYVNNFSTAVAVLKKTCATKPAFL 515
Query: 375 VVLKEGDEEI--KSDIYTLFFHIVQRIPEYLIHLQNVLKFTEQEHPDYYLLLVCVQRLRV 432
LK+ E ++ +Y+L +QR P++++ LQ++LK T + HPD L + + L
Sbjct: 516 EFLKQEQEASPDRTTLYSLMMKPIQRFPQFILLLQDMLKNTSKGHPDRLPLQMALTELE- 574
Query: 433 FISHYTLLFQCNEDLLIQKRKKLKKSSMAKLYKGLASQCAN 473
TL + NE +KR ++ + ++ K + + N
Sbjct: 575 -----TLAEKLNE----RKRDADQRCEVKQIAKAINERYLN 606
>gi|21735572 epithelial cell transforming sequence 2 oncogene
protein [Homo sapiens]
Length = 883
Score = 47.8 bits (112), Expect = 4e-05
Identities = 42/190 (22%), Positives = 79/190 (41%), Gaps = 14/190 (7%)
Query: 261 SLAAKRQTVALELLESERKYVINISLILKIKATFQGSDGKRNS-----KERSLFPGSLRY 315
S + R VA EL ++E YV ++ I+++ +G+R +E GS+
Sbjct: 417 SKQSARWQVAKELYQTESNYVNILATIIQLFQVPLEEEGQRGGPILAPEEIKTIFGSIPD 476
Query: 316 LVQQHLDLLHALQERVLKWPRQGVLGDLFLKLTNDENNFLDYYVAYLRDLPECISL---- 371
+ H + L++ ++ W +GD+FLK + D +V + E I
Sbjct: 477 IFDVHTKIKDDLEDLIVNWDESKSIGDIFLKYSKDLVKTYPPFVNFFEMSKETIIKCEKQ 536
Query: 372 -----VHVVVLKEGDEEIKSDIYTLFFHIVQRIPEYLIHLQNVLKFTEQEHPDYYLLLVC 426
+ + + E + + L VQR+P + L ++ K T E+PD L
Sbjct: 537 KPRFHAFLKINQAKPECGRQSLVELLIRPVQRLPSVALLLNDLKKHTADENPDKSTLEKA 596
Query: 427 VQRLRVFISH 436
+ L+ ++H
Sbjct: 597 IGSLKEVMTH 606
>gi|58761492 Rho guanine nucleotide exchange factor (GEF) 10-like
isoform 1 [Homo sapiens]
Length = 1279
Score = 46.6 bits (109), Expect = 1e-04
Identities = 39/156 (25%), Positives = 72/156 (46%), Gaps = 22/156 (14%)
Query: 326 ALQERVLKWPRQGVLGDLFLKLTNDENNFLDYYVAYLRDLPECISLVHVVVL-------- 377
AL RV +W +GDLF+ + ++ LD Y Y+ + +S++ L
Sbjct: 379 ALSSRVAEWDSTEKIGDLFVA-SFSKSMVLDVYSDYVNNFTSAMSIIKKACLTKPAFLEF 437
Query: 378 ---KEGDEEIKSDIYTLFFHIVQRIPEYLIHLQNVLKFTEQEHPDYYLLLVCVQRLRVFI 434
++ + +Y L +QR P++++ LQ++LK T + HPD L + + L
Sbjct: 438 LKRRQVCSPDRVTLYGLMVKPIQRFPQFILLLQDMLKNTPRGHPDRLSLQLALTELE--- 494
Query: 435 SHYTLLFQCNEDLLIQKRKKLKKSSMAKLYKGLASQ 470
TL + NE QKR + + + +L K ++ +
Sbjct: 495 ---TLAEKLNE----QKRLADQVAEIQQLTKSVSDR 523
>gi|74136547 Rho guanine nucleotide exchange factor (GEF) 10-like
isoform 2 [Homo sapiens]
Length = 1240
Score = 46.6 bits (109), Expect = 1e-04
Identities = 39/156 (25%), Positives = 72/156 (46%), Gaps = 22/156 (14%)
Query: 326 ALQERVLKWPRQGVLGDLFLKLTNDENNFLDYYVAYLRDLPECISLVHVVVL-------- 377
AL RV +W +GDLF+ + ++ LD Y Y+ + +S++ L
Sbjct: 340 ALSSRVAEWDSTEKIGDLFVA-SFSKSMVLDVYSDYVNNFTSAMSIIKKACLTKPAFLEF 398
Query: 378 ---KEGDEEIKSDIYTLFFHIVQRIPEYLIHLQNVLKFTEQEHPDYYLLLVCVQRLRVFI 434
++ + +Y L +QR P++++ LQ++LK T + HPD L + + L
Sbjct: 399 LKRRQVCSPDRVTLYGLMVKPIQRFPQFILLLQDMLKNTPRGHPDRLSLQLALTELE--- 455
Query: 435 SHYTLLFQCNEDLLIQKRKKLKKSSMAKLYKGLASQ 470
TL + NE QKR + + + +L K ++ +
Sbjct: 456 ---TLAEKLNE----QKRLADQVAEIQQLTKSVSDR 484
>gi|24797153 faciogenital dysplasia protein [Homo sapiens]
Length = 961
Score = 45.8 bits (107), Expect = 2e-04
Identities = 46/182 (25%), Positives = 82/182 (45%), Gaps = 29/182 (15%)
Query: 259 ETSLAAKRQTVALELLESERKYVINISLILKIKATFQGSDGKRNSKERSLFPGSLRYLVQ 318
E ++ K +A ELL++E+ YV + L+ ++ + ++ RS FP + + +
Sbjct: 367 ELTVQQKVFHIANELLQTEKAYVSRLHLLDQVFCARLLEE----ARNRSSFPADVVHGIF 422
Query: 319 QHLD---------LLHALQERVLKWPRQGVLGDLFLKLTNDENNFLDYYVAYLRDLPECI 369
++ LL L++R+ +W R +GD+ KL FL Y Y+++ +
Sbjct: 423 SNICSIYCFHQQFLLPELEKRMEEWDRYPRIGDILQKLA----PFLKMYGEYVKNFDRAV 478
Query: 370 SLVHV---------VVLKEGDEEIKSDIYTLFFHI---VQRIPEYLIHLQNVLKFTEQEH 417
LV+ V++ E +E TL H+ VQRIP Y + L++ L
Sbjct: 479 ELVNTWTERSTQFKVIIHEVQKEEACGNLTLQHHMLEPVQRIPRYELLLKDYLLKLPHGS 538
Query: 418 PD 419
PD
Sbjct: 539 PD 540
>gi|134133248 FYVE, RhoGEF and PH domain containing 3 [Homo sapiens]
Length = 725
Score = 45.8 bits (107), Expect = 2e-04
Identities = 56/213 (26%), Positives = 90/213 (42%), Gaps = 30/213 (14%)
Query: 222 QPKDGKEWGEEYVTKDHPDKL-KEAGQGRHSSLENVLCETSLAAKRQTVALELLESERKY 280
Q + + GEE +++ P K K+AG +HS + +L +A ELL +E Y
Sbjct: 123 QEEADSDVGEEPDSENTPQKADKDAGLAQHSGPQKLL----------HIAQELLHTEETY 172
Query: 281 VINISLILKIKATFQGSDGKRNSKERSLFPGSLRYLVQQHLDLLHALQERVLK-WPRQGV 339
V + L+ ++ T G +F LL L+ R+ + W
Sbjct: 173 VKRLHLLDQVFCTRLTDAGIPPEVIMGIFSNISSIHRFHGQFLLPELKTRITEEWDTNPR 232
Query: 340 LGDLFLKLTNDENNFLDYYVAYLRDLPECISLVHV----------VVLKEGDEEIKSDIY 389
LGD+ KL FL Y Y+++ + LV VV +E+ ++
Sbjct: 233 LGDILQKLAP----FLKMYGEYVKNFDRAVGLVSTWTQRSPLFKDVVHSIQKQEVCGNL- 287
Query: 390 TLFFHI---VQRIPEYLIHLQNVLKFTEQEHPD 419
TL H+ VQR+P Y + L++ LK Q+ PD
Sbjct: 288 TLQHHMLEPVQRVPRYELLLKDYLKRLPQDAPD 320
>gi|134133265 FYVE, RhoGEF and PH domain containing 3 [Homo sapiens]
Length = 725
Score = 45.8 bits (107), Expect = 2e-04
Identities = 56/213 (26%), Positives = 90/213 (42%), Gaps = 30/213 (14%)
Query: 222 QPKDGKEWGEEYVTKDHPDKL-KEAGQGRHSSLENVLCETSLAAKRQTVALELLESERKY 280
Q + + GEE +++ P K K+AG +HS + +L +A ELL +E Y
Sbjct: 123 QEEADSDVGEEPDSENTPQKADKDAGLAQHSGPQKLL----------HIAQELLHTEETY 172
Query: 281 VINISLILKIKATFQGSDGKRNSKERSLFPGSLRYLVQQHLDLLHALQERVLK-WPRQGV 339
V + L+ ++ T G +F LL L+ R+ + W
Sbjct: 173 VKRLHLLDQVFCTRLTDAGIPPEVIMGIFSNISSIHRFHGQFLLPELKTRITEEWDTNPR 232
Query: 340 LGDLFLKLTNDENNFLDYYVAYLRDLPECISLVHV----------VVLKEGDEEIKSDIY 389
LGD+ KL FL Y Y+++ + LV VV +E+ ++
Sbjct: 233 LGDILQKLAP----FLKMYGEYVKNFDRAVGLVSTWTQRSPLFKDVVHSIQKQEVCGNL- 287
Query: 390 TLFFHI---VQRIPEYLIHLQNVLKFTEQEHPD 419
TL H+ VQR+P Y + L++ LK Q+ PD
Sbjct: 288 TLQHHMLEPVQRVPRYELLLKDYLKRLPQDAPD 320
>gi|45439359 triple functional domain (PTPRF interacting) [Homo
sapiens]
Length = 3097
Score = 45.4 bits (106), Expect = 2e-04
Identities = 43/170 (25%), Positives = 80/170 (47%), Gaps = 17/170 (10%)
Query: 259 ETSLAAKRQTVALELLESERKYVINISLILKIKATFQGSDG---KRNSKERSLFPGSLRY 315
++S +R V EL+E+ER YV ++ +++ DG K++ +F G++
Sbjct: 1963 KSSSLKRRHYVLQELVETERDYVRDLGYVVEGYMALMKEDGVPDDMKGKDKIVF-GNIHQ 2021
Query: 316 LVQQHLDLLHALQERVLKWPRQGVLGDLFLKLTNDENNFLDYYVAYLRDLPECISLVHVV 375
+ H D E+ L+ P + LG LF+K L Y+AY ++ P+ +V
Sbjct: 2022 IYDWHRDFFLGELEKCLEDPEK--LGSLFVK----HERRLHMYIAYCQNKPKSEHIVSEY 2075
Query: 376 VLKEGDEEIKS------DIYTLFFHIVQRIPEYLIHLQNVLKFTEQEHPD 419
+ E++K + L VQRI +Y + L++ LK++++ D
Sbjct: 2076 I-DTFFEDLKQRLGHRLQLTDLLIKPVQRIMKYQLLLKDFLKYSKKASLD 2124
>gi|21361458 Rho guanine nucleotide exchange factor (GEF) 17 [Homo
sapiens]
Length = 2063
Score = 45.1 bits (105), Expect = 3e-04
Identities = 45/192 (23%), Positives = 86/192 (44%), Gaps = 23/192 (11%)
Query: 258 CETSLAAKRQTVALELLESERKYVINISLILKIKATFQGSDGKRNSK--ERSLFP---GS 312
C R+ VA+ LL++E+ YV ++ +++ Q NS + SL
Sbjct: 1059 CSKPQVDMRKHVAMTLLDTEQSYVESLRTLMQ--GYMQPLKQPENSVLCDPSLVDEIFDQ 1116
Query: 313 LRYLVQQHLDLLHALQERVLKWPRQGVLGDLFLKLTNDENNFLDYYVAYLRDLPECISLV 372
+ L++ H L ++ + W Q +G L ++ + ++ ++ Y AY+ + V
Sbjct: 1117 IPELLEHHEQFLEQVRHCMQTWHAQQKVGALLVQ-SFSKDVLVNIYSAYIDNFLNAKDAV 1175
Query: 373 HVVV-------------LKEGDEEIKSDIYTLFFHIVQRIPEYLIHLQNVLKFTEQEHPD 419
V ++E E K + L VQRIP Y + ++++LK T ++HPD
Sbjct: 1176 RVAKEARPAFLKFLEQSMRENKE--KQALSDLMIKPVQRIPRYELLVKDLLKHTPEDHPD 1233
Query: 420 YYLLLVCVQRLR 431
+ LLL + ++
Sbjct: 1234 HPLLLEAQRNIK 1245
>gi|58530876 melanoma antigen family C, 1 [Homo sapiens]
Length = 1142
Score = 44.3 bits (103), Expect = 5e-04
Identities = 54/243 (22%), Positives = 98/243 (40%), Gaps = 30/243 (12%)
Query: 468 ASQCANAGQDASPTAGPEAVRDTGIHSEELLQPYPSAPSSGPAITHLMPPVKKSQQQQSL 527
+SQ G SP P++ + G+HS+ LQ SAP +++ L P + + SL
Sbjct: 647 SSQSPPEGPVQSPLHSPQSPPE-GMHSQSPLQSPESAPEGEDSLSPLQIPQSPLEGEDSL 705
Query: 528 MESMQPGKPSDWE----------LEGRKHERPESLLAPTQFCAAEQDVKALAGPLQAIPE 577
P P +WE + + SL +P C++ + ++P+
Sbjct: 706 SSLHFPQSPPEWEDSLSPLHFPQFPPQGEDFQSSLQSPVSICSSSTSL--------SLPQ 757
Query: 578 MDFESSPAEPLGNVERSLRAPAE--LLPDARGFVPAAYEEFEYGGEIFALPAPYDEEPFQ 635
ES + P G + L+ P + +++E + + P + P Q
Sbjct: 758 SFPESPQSPPEGPAQSPLQRPVSSFFSYTLASLLQSSHESPQ------SPPEGPAQSPLQ 811
Query: 636 AP--ALFENCSPASSESSLDICFLRPVSFAMEAERPEHPLQPLPKSATSPAGSSSAYKLE 693
+P + + S + S+SS F S ++ PE PLQ P + S + S S + E
Sbjct: 812 SPVSSFPSSTSSSLSQSSPVSSFPSSTSSSLSKSSPESPLQS-PVISFSSSTSLSPFSEE 870
Query: 694 AAA 696
+++
Sbjct: 871 SSS 873
Score = 30.0 bits (66), Expect = 9.4
Identities = 60/281 (21%), Positives = 107/281 (38%), Gaps = 53/281 (18%)
Query: 463 LYKGLASQCANAGQDAS-PTAGPEAVRDTGIHSEELLQPYPSAPSSGPAITHLMPPVKKS 521
LY + Q + G+D+S P P +D S+ LQ P S P P++ S
Sbjct: 48 LYPLQSPQSRSEGEDSSDPLQRPPEGKD----SQSPLQ----IPQSSPEGDDTQSPLQNS 99
Query: 522 QQQQSLMESMQPGKPSDWELEGRKHERPESLLAPTQFCAA-----EQDVKALAGPLQAIP 576
Q +S+ P + S EG + P A + F +A + ++ P + P
Sbjct: 100 QSSPEGKDSLSPLEISQSPPEGEDVQSPLQNPASSFFSSALLSIFQSSPESTQSPFEGFP 159
Query: 577 E----------------MDFESSPAEPLGNVERSLRAPAELLPDARGFVPAAYEEFEYGG 620
+ F+SSP E ++P + +P +R F F+
Sbjct: 160 QSVLQIPVSAASSSTLVSIFQSSPESTQSPFEGFPQSPLQ-IPVSRSFSSTLLSIFQSSP 218
Query: 621 E-IFALPAPYDEEPFQAPALFENCSPASSESSLDICFLRPVSFAMEAERPEHPLQPLPKS 679
E + + + P Q P SP+SS + L + F +ER + + +S
Sbjct: 219 ERTQSTFEGFAQSPLQIPV-----SPSSSSTLLSL-------FQSFSERTQSTFEGFAQS 266
Query: 680 A----TSPAGSSSAYKLEAAAQAHGKAKPLSRSLKEFPRAP 716
+ SP+ SS+ L ++ ++ + + FP++P
Sbjct: 267 SLQIPVSPSFSSTLVSLFQSSPERTQS-----TFEGFPQSP 302
>gi|22538387 A-kinase anchor protein 9 isoform 2 [Homo sapiens]
Length = 3907
Score = 43.9 bits (102), Expect = 6e-04
Identities = 71/372 (19%), Positives = 153/372 (41%), Gaps = 26/372 (6%)
Query: 27 QALASELKTGFTEAMQELSRIQHGEYALEEKVKSCRCSMEEKVTEMKNSLNYFKEELSNA 86
Q L E + E ++ + + L+++VK+ +EE+V+ EL +
Sbjct: 1992 QQLLQETEKLMKEKLEVQCQAEKVRDDLQKQVKALEIDVEEQVSRFIELEQEKNTELMDL 2051
Query: 87 MSMIQAITSKQEEMQQKIEQLQQEKRRESRKVKAKKTQKEEHSSQAGPAQAQGSPFRSIN 146
QA+ + E+M++ +++ Q R R V ++ QK E + P S ++
Sbjct: 2052 RQQNQALEKQLEKMRKFLDE-QAIDREHERDVFQQEIQKLEQQLKVVPRFQPISEHQTRE 2110
Query: 147 IPEPVLPSEDFTNLLPSQAYEKAQESRSVHVGDSNVKGM--------MGPGVNPTTPEAE 198
+ + ++ T+ K Q R + + ++ + V+ T +
Sbjct: 2111 VEQLANHLKEKTDKCSELLLSKEQLQRDIQERNEEIEKLEFRVRELEQALLVSADTFQKV 2170
Query: 199 ENLKSCLSADIQSKGHLPSGMWRQPKDGKEWGEEYVT--KDHPDKLKEAGQGRHSSLENV 256
E+ K + + + + L + + +D + E+ +T ++ ++ +E + ++ ++ +
Sbjct: 2171 EDRKHFGAVEAKPELSLEVQL-QAERDAIDRKEKEITNLEEQLEQFREELENKNEEVQQL 2229
Query: 257 LCETSLAAKRQTVALELLESERKYVINISLILKIKATFQGSDGKRNSKERSLFPGSLRYL 316
+ + K T L+ LE E K + + K+ + SD + LF G +
Sbjct: 2230 HMQLEIQKKESTTRLQELEQENKLFKDD--MEKLGLAIKESDAMSTQDQHVLF-GKFAQI 2286
Query: 317 VQQHLDLLHALQERVLKWPRQGVLGDLFLKLTNDENNFLDYYVAYLRDLP---ECISLVH 373
+Q+ + L E+V K +Q LK+T D N ++ +RDL EC+
Sbjct: 2287 IQEKEVEIDQLNEQVTKLQQQ-------LKITTD-NKVIEEKNELIRDLETQIECLMSDQ 2338
Query: 374 VVVLKEGDEEIK 385
V + +EEI+
Sbjct: 2339 ECVKRNREEEIE 2350
Score = 34.3 bits (77), Expect = 0.50
Identities = 26/92 (28%), Positives = 46/92 (50%), Gaps = 6/92 (6%)
Query: 41 MQELSRIQHGEYALEEKVKSCRCS-MEEKVTEMKNSLNYFKEELSNAMSMIQAITSKQEE 99
+Q L++++ E + + R S +E +V EM SL KE++ A + K E
Sbjct: 2586 IQNLNQLREDELGSDISALTLRISELESQVVEMHTSLILEKEQVEIAEKNVLEKEKKLLE 2645
Query: 100 MQQKIE-----QLQQEKRRESRKVKAKKTQKE 126
+Q+ +E Q ++EK+R + V+ KT E
Sbjct: 2646 LQKLLEGNEKKQREKEKKRSPQDVEVLKTTTE 2677
Score = 33.1 bits (74), Expect = 1.1
Identities = 51/182 (28%), Positives = 75/182 (41%), Gaps = 33/182 (18%)
Query: 7 KQGENEHMPVNNPSTQIYQLQ-ALASELKTGFTEAMQELSRIQHGEYALE-EKVKSCRCS 64
K+ E + V + + +++ L LASE K +EL ++ALE EK K R
Sbjct: 3187 KELEAFRLEVKDKTDEVHLLNDTLASEQKKS-----REL------QWALEKEKAKLGRSE 3235
Query: 65 MEEK--VTEMKNSLNYFKEELSNAMSMIQAITSKQEEMQQKIE--------QLQQEKRR- 113
+K + ++K SL K+ +++ E QQKIE QL +E+ R
Sbjct: 3236 ERDKEELEDLKFSLESQKQRNLQLNLLLEQQKQLLNESQQKIESQRMLYDAQLSEEQGRN 3295
Query: 114 -------ESRKVKAKKTQKEEHSSQAGPAQAQGSPFRSINIPEPVLPSEDFTNLLPSQAY 166
ES KV+ ++ + AQ Q S P LPSED L Q
Sbjct: 3296 LELQVLLESEKVRIREMSSTLDRERELHAQLQSSD--GTGQSRPPLPSEDLLKELQKQLE 3353
Query: 167 EK 168
EK
Sbjct: 3354 EK 3355
Score = 32.3 bits (72), Expect = 1.9
Identities = 22/115 (19%), Positives = 54/115 (46%), Gaps = 4/115 (3%)
Query: 2 EKTKTKQGENEHMPVNNPSTQIYQLQALASELKTGFTEAMQELSRIQHGEYALEEKVKSC 61
EK K + E + N+ +I + + + EL T E ++ ++ ++ +
Sbjct: 303 EKIKVYEMEQDKKVENSNKEEIQEKETIIEELNTKIIEEEKKTLELKDKLTTADKLLGEL 362
Query: 62 RCSMEEKVTEMKNSLNYFKEELSNAMSMIQAITSKQEEMQQKIEQLQQEKRRESR 116
+ + +K E+KN K EL+N+ + + + +++ +E+LQ+ ++S+
Sbjct: 363 QEQIVQKNQEIKN----MKLELTNSKQKERQSSEEIKQLMGTVEELQKRNHKDSQ 413
Score = 32.0 bits (71), Expect = 2.5
Identities = 34/160 (21%), Positives = 66/160 (41%), Gaps = 35/160 (21%)
Query: 10 ENEHMPVNNPSTQIYQLQALASELKTGFTEAMQELSRIQHGEYAL--------EEKVKSC 61
ENE + +N S +LQA +L +E +L + + L +E +S
Sbjct: 1838 ENEELMLNISS----RLQAAVEKLLEAISETSSQLEHAKVTQTELMRESFRQKQEATESL 1893
Query: 62 RCSME--EKVTEMKNSLNYFKEELSNAMSMIQAITSK----QEEMQQK------------ 103
+C E E++ E + ELS A +I + + ++Q+K
Sbjct: 1894 KCQEELRERLHEESRAREQLAVELSKAEGVIDGYADEKTLFERQIQEKTDIIDRLEQELL 1953
Query: 104 -----IEQLQQEKRRESRKVKAKKTQKEEHSSQAGPAQAQ 138
+++L+ E+++ + + QKE ++AGP + Q
Sbjct: 1954 CASNRLQELEAEQQQIQEERELLSRQKEAMKAEAGPVEQQ 1993
>gi|39930351 dynamin binding protein [Homo sapiens]
Length = 1577
Score = 42.7 bits (99), Expect = 0.001
Identities = 55/232 (23%), Positives = 101/232 (43%), Gaps = 43/232 (18%)
Query: 259 ETSLAAKRQTVALELLESERKYVINISLILKIKATFQGSDGKRNSKERSLFPGSLRYLVQ 318
E + KR V ELL++ER Y+ ++ + ++ N LF G+++ +++
Sbjct: 778 EQRMLEKRAKVIEELLQTERDYIRDLEMCIERIMVPMQQAQVPNIDFEGLF-GNMQMVIK 836
Query: 319 QHLDLLHALQERVLKWPRQGVLGDLFLKLTNDENNFLDYYVAYLRDLPECISLVHVVVLK 378
LL AL+ +G +FL + Y Y ++ E I+L+ +
Sbjct: 837 VSKQLLAALEI-------SDAVGPVFL---GHRDELEGTYKIYCQNHDEAIALLEIY--- 883
Query: 379 EGDEEIK-------SDIYTLF---------------FHIVQRIPEYLIHLQNVLKFTEQE 416
E DE+I+ +D+ +L+ VQR+ Y + L +L T +
Sbjct: 884 EKDEKIQKHLQDSLADLKSLYNEWGCTNYINLGSFLIKPVQRVMRYPLLLMELLNSTPES 943
Query: 417 HPDYYLL---LVCVQRLRVFISHYTLLFQCNEDLLIQKRKKLKKSSMAKLYK 465
HPD L ++ V+ + V I+ Y + +DL+++ RK + S M K+ K
Sbjct: 944 HPDKVPLTNAVLAVKEINVNINEY----KRRKDLVLKYRKGDEDSLMEKISK 991
>gi|31982906 cingulin-like 1 [Homo sapiens]
Length = 1302
Score = 42.0 bits (97), Expect = 0.002
Identities = 24/103 (23%), Positives = 56/103 (54%), Gaps = 4/103 (3%)
Query: 25 QLQALASELKTGFTEAMQELSRIQHGEYALEEKVKSCRCSMEEKVTEMKNSLNYFKEELS 84
+LQ + EL+ + +++ ++ E +E +K E ++ +++ +L + ++E
Sbjct: 833 KLQGRSEELERRVAQLQRQIEDLKGDEAKAKETLKK----YEGEIRQLEEALVHARKEEK 888
Query: 85 NAMSMIQAITSKQEEMQQKIEQLQQEKRRESRKVKAKKTQKEE 127
A+S +A+ ++ E Q + Q QE+++ S K+K + QKE+
Sbjct: 889 EAVSARRALENELEAAQGNLSQTTQEQKQLSEKLKEESEQKEQ 931
Score = 32.0 bits (71), Expect = 2.5
Identities = 25/107 (23%), Positives = 47/107 (43%), Gaps = 14/107 (13%)
Query: 32 ELKTGFTEAMQELSRIQHGEYALEEKVKSCRCSMEEKVTEMKNSLNYFKEELSNAMSMIQ 91
E K+ T + EL R E ++ +K R M + E+++ N EE S
Sbjct: 614 EQKSKLTIEVAELQRQLQLEVKNQQNIKEERERMRANLEELRSQHNEKVEENST------ 667
Query: 92 AITSKQEEMQQKIEQLQQEKRRESRKVKAKKTQKEEHSSQAGPAQAQ 138
+QQ++E+ + E R+ ++ K ++E+H ++ Q Q
Sbjct: 668 --------LQQRLEESEGELRKNLEELFQVKMEREQHQTEIRDLQDQ 706
Score = 31.6 bits (70), Expect = 3.2
Identities = 26/112 (23%), Positives = 48/112 (42%), Gaps = 2/112 (1%)
Query: 3 KTKTKQGENEHMPVNNPSTQ--IYQLQALASELKTGFTEAMQELSRIQHGEYALEEKVKS 60
+ K Q ENE + + + + QLQ +LK +A + L + + LEE +
Sbjct: 823 RVKLLQEENEKLQGRSEELERRVAQLQRQIEDLKGDEAKAKETLKKYEGEIRQLEEALVH 882
Query: 61 CRCSMEEKVTEMKNSLNYFKEELSNAMSMIQAITSKQEEMQQKIEQLQQEKR 112
R +E V+ + N + N Q E+++++ EQ +Q +R
Sbjct: 883 ARKEEKEAVSARRALENELEAAQGNLSQTTQEQKQLSEKLKEESEQKEQLRR 934
Score = 31.6 bits (70), Expect = 3.2
Identities = 31/138 (22%), Positives = 64/138 (46%), Gaps = 17/138 (12%)
Query: 3 KTKTKQGENEHMPVNNPSTQIYQLQALASELKTGFTEAMQELSRIQHG----EYALEEK- 57
K KT + E + ++ ++ + + EA+ + ++ EY LE K
Sbjct: 994 KEKTLEAEKSRLTAMKMQDEMRLMEEELRDYQRAQDEALTKRQLLEQTLKDLEYELEAKS 1053
Query: 58 -VKSCRC----SMEEKVTEMKNSLNYFKEELSNAMSMIQAITSKQEEMQQKIEQLQQEKR 112
+K R ME+KV++++ L +EE +N+ + + I+ +E+M+Q +L QE+
Sbjct: 1054 HLKDDRSRLVKQMEDKVSQLEMEL---EEERNNSDLLSERISRSREQMEQLRNELLQERA 1110
Query: 113 R----ESRKVKAKKTQKE 126
E K+ ++ K+
Sbjct: 1111 ARQDLECDKISLERQNKD 1128
Score = 30.8 bits (68), Expect = 5.5
Identities = 27/113 (23%), Positives = 57/113 (50%), Gaps = 17/113 (15%)
Query: 27 QALASELKTGFTEAMQELSRIQHGEYALEEKVKSCRCSMEEKVTEMKNSLNYFK------ 80
+AL +EL+ A LS+ + L EK+K +E++ +KN + +
Sbjct: 895 RALENELEA----AQGNLSQTTQEQKQLSEKLKE-ESEQKEQLRRLKNEMENERWHLGKT 949
Query: 81 -EELSNAMS-MIQAITSKQEEMQQKIEQLQQEKRRE----SRKVKAKKTQKEE 127
E+L M+ +++A + E+Q ++++ +++ RRE R++K K + E+
Sbjct: 950 IEKLQKEMADIVEASRTSTLELQNQLDEYKEKNRRELAEMQRQLKEKTLEAEK 1002
>gi|38683807 ankyrin repeat domain protein 17 isoform a [Homo
sapiens]
Length = 2603
Score = 42.0 bits (97), Expect = 0.002
Identities = 30/141 (21%), Positives = 69/141 (48%), Gaps = 23/141 (16%)
Query: 3 KTKTKQGENEHMPVNNPSTQIY-----------QLQALASELKTGFTEAMQELSRIQHGE 51
K +KQ + H+P N+ Q Y + Q +EL+ EA+++ +++Q E
Sbjct: 777 KAASKQKSSSHLPANSQDVQGYITNQSPESIVEEAQGKLTELEQRIKEAIEKNAQLQSLE 836
Query: 52 YALEEKVKSCRCSMEEKVTEMKNSLNYFKEELSNAMSMIQAITSKQEEMQQKIEQLQQEK 111
A +++ +EK+ E+ + +E++ +++ + + E+Q K QQ+
Sbjct: 837 LAHADQL------TKEKIEELNKTR---EEQIQKKQKILEELQKVERELQLK---TQQQL 884
Query: 112 RRESRKVKAKKTQKEEHSSQA 132
+++ +VKA++ Q ++ Q+
Sbjct: 885 KKQYLEVKAQRIQLQQQQQQS 905
>gi|229094128 active breakpoint cluster region-related protein
isoform c [Homo sapiens]
Length = 813
Score = 41.6 bits (96), Expect = 0.003
Identities = 45/200 (22%), Positives = 81/200 (40%), Gaps = 24/200 (12%)
Query: 266 RQTVALELLESERKYVINISLIL----KIKATFQGSDGKRNSKERSLFPGSLRYLVQQHL 321
R+ V L SE Y+ + +L +KAT S ++ ++ + + H
Sbjct: 46 RKLVLSGFLASEEIYINQLEALLLPMKPLKATATTSQPVLTIQQIETIFYKIQDIYEIHK 105
Query: 322 DLLHALQERVLKWPRQGVLGDLFLKLTND---ENNFLDYYVAYLRDLPEC------ISLV 372
+ L +V +W Q +G LF KL + F+D Y L +C +
Sbjct: 106 EFYDNLCPKVQQWDSQVTMGHLFQKLASQLGVYKAFVDNYKVALETAEKCSQSNNQFQKI 165
Query: 373 HVVVLKEGDEEIKSD-----IYTLFFHIVQRIPEYLIHLQNVLKFTEQEHPDYYLLLVCV 427
+ +G ++ K + L + + R+ + L ++LK T +HPDY LL +
Sbjct: 166 SEELKVKGPKDSKDSHTSVTMEALLYKPIDRVTRSTLVLHDLLKHTPVDHPDYPLLQDAL 225
Query: 428 QRLRVFISHYTLLFQCNEDL 447
+ + F+S NED+
Sbjct: 226 RISQNFLS------SINEDI 239
>gi|38679957 active breakpoint cluster region-related protein
isoform a [Homo sapiens]
Length = 859
Score = 41.6 bits (96), Expect = 0.003
Identities = 45/200 (22%), Positives = 81/200 (40%), Gaps = 24/200 (12%)
Query: 266 RQTVALELLESERKYVINISLIL----KIKATFQGSDGKRNSKERSLFPGSLRYLVQQHL 321
R+ V L SE Y+ + +L +KAT S ++ ++ + + H
Sbjct: 92 RKLVLSGFLASEEIYINQLEALLLPMKPLKATATTSQPVLTIQQIETIFYKIQDIYEIHK 151
Query: 322 DLLHALQERVLKWPRQGVLGDLFLKLTND---ENNFLDYYVAYLRDLPEC------ISLV 372
+ L +V +W Q +G LF KL + F+D Y L +C +
Sbjct: 152 EFYDNLCPKVQQWDSQVTMGHLFQKLASQLGVYKAFVDNYKVALETAEKCSQSNNQFQKI 211
Query: 373 HVVVLKEGDEEIKSD-----IYTLFFHIVQRIPEYLIHLQNVLKFTEQEHPDYYLLLVCV 427
+ +G ++ K + L + + R+ + L ++LK T +HPDY LL +
Sbjct: 212 SEELKVKGPKDSKDSHTSVTMEALLYKPIDRVTRSTLVLHDLLKHTPVDHPDYPLLQDAL 271
Query: 428 QRLRVFISHYTLLFQCNEDL 447
+ + F+S NED+
Sbjct: 272 RISQNFLS------SINEDI 285
>gi|38679954 active breakpoint cluster region-related protein
isoform b [Homo sapiens]
Length = 822
Score = 41.6 bits (96), Expect = 0.003
Identities = 45/200 (22%), Positives = 81/200 (40%), Gaps = 24/200 (12%)
Query: 266 RQTVALELLESERKYVINISLIL----KIKATFQGSDGKRNSKERSLFPGSLRYLVQQHL 321
R+ V L SE Y+ + +L +KAT S ++ ++ + + H
Sbjct: 55 RKLVLSGFLASEEIYINQLEALLLPMKPLKATATTSQPVLTIQQIETIFYKIQDIYEIHK 114
Query: 322 DLLHALQERVLKWPRQGVLGDLFLKLTND---ENNFLDYYVAYLRDLPEC------ISLV 372
+ L +V +W Q +G LF KL + F+D Y L +C +
Sbjct: 115 EFYDNLCPKVQQWDSQVTMGHLFQKLASQLGVYKAFVDNYKVALETAEKCSQSNNQFQKI 174
Query: 373 HVVVLKEGDEEIKSD-----IYTLFFHIVQRIPEYLIHLQNVLKFTEQEHPDYYLLLVCV 427
+ +G ++ K + L + + R+ + L ++LK T +HPDY LL +
Sbjct: 175 SEELKVKGPKDSKDSHTSVTMEALLYKPIDRVTRSTLVLHDLLKHTPVDHPDYPLLQDAL 234
Query: 428 QRLRVFISHYTLLFQCNEDL 447
+ + F+S NED+
Sbjct: 235 RISQNFLS------SINEDI 248
>gi|157738615 coiled-coil alpha-helical rod protein 1 isoform 1
[Homo sapiens]
Length = 871
Score = 41.2 bits (95), Expect = 0.004
Identities = 27/91 (29%), Positives = 54/91 (59%), Gaps = 6/91 (6%)
Query: 42 QELSRIQ--HGEYALEEKVKSCRCSMEEKVTEMKNSLNYFKEELSNA---MSMIQAITSK 96
QEL++ Q +G+ AL+EKV + E++++ + LN + E + A + IQ ++
Sbjct: 677 QELTQQQELYGQ-ALQEKVAEVETRLREQLSDTERRLNEARREHAKAVVSLRQIQRRAAQ 735
Query: 97 QEEMQQKIEQLQQEKRRESRKVKAKKTQKEE 127
++E Q++ +LQ+E R+E + A++ Q+ E
Sbjct: 736 EKERSQELRRLQEEARKEEGQRLARRLQELE 766
>gi|157738613 coiled-coil alpha-helical rod protein 1 isoform 2
[Homo sapiens]
Length = 835
Score = 41.2 bits (95), Expect = 0.004
Identities = 27/91 (29%), Positives = 54/91 (59%), Gaps = 6/91 (6%)
Query: 42 QELSRIQ--HGEYALEEKVKSCRCSMEEKVTEMKNSLNYFKEELSNA---MSMIQAITSK 96
QEL++ Q +G+ AL+EKV + E++++ + LN + E + A + IQ ++
Sbjct: 641 QELTQQQELYGQ-ALQEKVAEVETRLREQLSDTERRLNEARREHAKAVVSLRQIQRRAAQ 699
Query: 97 QEEMQQKIEQLQQEKRRESRKVKAKKTQKEE 127
++E Q++ +LQ+E R+E + A++ Q+ E
Sbjct: 700 EKERSQELRRLQEEARKEEGQRLARRLQELE 730
Database: hs.faa
Posted date: Aug 4, 2009 4:42 PM
Number of letters in database: 18,247,518
Number of sequences in database: 37,866
Lambda K H
0.313 0.129 0.372
Gapped
Lambda K H
0.267 0.0410 0.140
Matrix: BLOSUM62
Gap Penalties: Existence: 11, Extension: 1
Number of Hits to DB: 35,258,806
Number of Sequences: 37866
Number of extensions: 1828730
Number of successful extensions: 12100
Number of sequences better than 10.0: 30
Number of HSP's better than 10.0 without gapping: 173
Number of HSP's successfully gapped in prelim test: 528
Number of HSP's that attempted gapping in prelim test: 9219
Number of HSP's gapped (non-prelim): 2957
length of query: 844
length of database: 18,247,518
effective HSP length: 111
effective length of query: 733
effective length of database: 14,044,392
effective search space: 10294539336
effective search space used: 10294539336
T: 11
A: 40
X1: 16 ( 7.2 bits)
X2: 38 (14.6 bits)
X3: 64 (24.7 bits)
S1: 42 (21.9 bits)
S2: 66 (30.0 bits)
Search results were obtained with NCBI BLAST and RefSeq entries.
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Guide to the Human Genome
Copyright © 2010 by Stewart Scherer. All rights reserved.