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Search of human proteins with 223718070
BLASTP 2.2.11 [Jun-05-2005]
Reference: Altschul, Stephen F., Thomas L. Madden, Alejandro A. Schaffer,
Jinghui Zhang, Zheng Zhang, Webb Miller, and David J. Lipman (1997),
"Gapped BLAST and PSI-BLAST: a new generation of protein database search
programs", Nucleic Acids Res. 25:3389-3402.
Query= gi|223718070 retinoic acid receptor, alpha isoform 4 [Homo
sapiens]
(365 letters)
Database: hs.faa
37,866 sequences; 18,247,518 total letters
Searching..................................................done
Score E
Sequences producing significant alignments: (bits) Value
gi|223718070 retinoic acid receptor, alpha isoform 4 [Homo sapiens] 742 0.0
gi|223718064 retinoic acid receptor, alpha isoform 1 [Homo sapiens] 615 e-176
gi|67459914 retinoic acid receptor, alpha isoform 2 [Homo sapiens] 615 e-176
gi|4506419 retinoic acid receptor, alpha isoform 1 [Homo sapiens] 615 e-176
gi|14916494 retinoic acid receptor, beta isoform 1 [Homo sapiens] 479 e-135
gi|7706625 retinoic acid receptor, beta isoform 2 [Homo sapiens] 479 e-135
gi|112181200 retinoic acid receptor, gamma isoform 2 [Homo sapiens] 445 e-125
gi|4506423 retinoic acid receptor, gamma isoform 1 [Homo sapiens] 445 e-125
gi|40806160 thyroid hormone receptor, alpha isoform 1 [Homo sapi... 163 3e-40
gi|189491771 thyroid hormone receptor, beta [Homo sapiens] 150 1e-36
gi|189491769 thyroid hormone receptor, beta [Homo sapiens] 150 1e-36
gi|40806162 thyroid hormone receptor, beta [Homo sapiens] 150 1e-36
gi|20127452 thyroid hormone receptor, alpha isoform 2 [Homo sapi... 137 1e-32
gi|85362735 nuclear receptor subfamily 1, group H, member 2 [Hom... 133 2e-31
gi|224177493 nuclear receptor subfamily 1, group D, member 2 iso... 127 2e-29
gi|224177491 nuclear receptor subfamily 1, group D, member 2 iso... 127 2e-29
gi|194294519 nuclear receptor subfamily 1, group H, member 3 iso... 123 3e-28
gi|194294517 nuclear receptor subfamily 1, group H, member 3 iso... 123 3e-28
gi|13430848 nuclear receptor subfamily 1, group D, member 1 [Hom... 121 1e-27
gi|5902068 retinoid X receptor, gamma isoform a [Homo sapiens] 108 8e-24
gi|4506755 retinoid X receptor, alpha [Homo sapiens] 99 5e-21
gi|11415052 retinoid X receptor, beta [Homo sapiens] 99 8e-21
gi|5453822 nuclear receptor subfamily 4, group A, member 2 [Homo... 97 3e-20
gi|27894344 nuclear receptor subfamily 4, group A, member 1 [Hom... 96 4e-20
gi|21361342 nuclear receptor subfamily 4, group A, member 1 [Hom... 96 4e-20
gi|45545429 estrogen-related receptor gamma isoform 2 [Homo sapi... 96 5e-20
gi|45545427 estrogen-related receptor gamma isoform 2 [Homo sapi... 96 5e-20
gi|45545433 estrogen-related receptor gamma isoform 1 [Homo sapi... 96 5e-20
gi|197209821 estrogen-related receptor gamma isoform 2 [Homo sap... 96 5e-20
gi|238550159 estrogen-related receptor beta [Homo sapiens] 94 1e-19
>gi|223718070 retinoic acid receptor, alpha isoform 4 [Homo sapiens]
Length = 365
Score = 742 bits (1915), Expect = 0.0
Identities = 365/365 (100%), Positives = 365/365 (100%)
Query: 1 MASNSSSCPTPGGGHLNGYPVPPYAFFFPPMLGGLSPPGALTTLQHQLPVSGYSTPSPAT 60
MASNSSSCPTPGGGHLNGYPVPPYAFFFPPMLGGLSPPGALTTLQHQLPVSGYSTPSPAT
Sbjct: 1 MASNSSSCPTPGGGHLNGYPVPPYAFFFPPMLGGLSPPGALTTLQHQLPVSGYSTPSPAT 60
Query: 61 VRNDRNKKKKEVPKPECSESYTLTPEVGELIEKVRKAHQETFPALCQLGKYTTNNSSEQR 120
VRNDRNKKKKEVPKPECSESYTLTPEVGELIEKVRKAHQETFPALCQLGKYTTNNSSEQR
Sbjct: 61 VRNDRNKKKKEVPKPECSESYTLTPEVGELIEKVRKAHQETFPALCQLGKYTTNNSSEQR 120
Query: 121 VSLDIDLWDKFSELSTKCIIKTVEFAKQLPGFTTLTIADQITLLKAACLDILILRICTRY 180
VSLDIDLWDKFSELSTKCIIKTVEFAKQLPGFTTLTIADQITLLKAACLDILILRICTRY
Sbjct: 121 VSLDIDLWDKFSELSTKCIIKTVEFAKQLPGFTTLTIADQITLLKAACLDILILRICTRY 180
Query: 181 TPEQDTMTFSDGLTLNRTQMHNAGFGPLTDLVFAFANQLLPLEMDDAETGLLSAICLICG 240
TPEQDTMTFSDGLTLNRTQMHNAGFGPLTDLVFAFANQLLPLEMDDAETGLLSAICLICG
Sbjct: 181 TPEQDTMTFSDGLTLNRTQMHNAGFGPLTDLVFAFANQLLPLEMDDAETGLLSAICLICG 240
Query: 241 DRQDLEQPDRVDMLQEPLLEALKVYVRKRRPSRPHMFPKMLMKITDLRSISAKGAERVIT 300
DRQDLEQPDRVDMLQEPLLEALKVYVRKRRPSRPHMFPKMLMKITDLRSISAKGAERVIT
Sbjct: 241 DRQDLEQPDRVDMLQEPLLEALKVYVRKRRPSRPHMFPKMLMKITDLRSISAKGAERVIT 300
Query: 301 LKMEIPGSMPPLIQEMLENSEGLDTLSGQPGGGGRDGGGLAPPPGSCSPSLSPSSNRSSP 360
LKMEIPGSMPPLIQEMLENSEGLDTLSGQPGGGGRDGGGLAPPPGSCSPSLSPSSNRSSP
Sbjct: 301 LKMEIPGSMPPLIQEMLENSEGLDTLSGQPGGGGRDGGGLAPPPGSCSPSLSPSSNRSSP 360
Query: 361 ATHSP 365
ATHSP
Sbjct: 361 ATHSP 365
>gi|223718064 retinoic acid receptor, alpha isoform 1 [Homo sapiens]
Length = 462
Score = 615 bits (1585), Expect = e-176
Identities = 306/309 (99%), Positives = 307/309 (99%)
Query: 57 SPATVRNDRNKKKKEVPKPECSESYTLTPEVGELIEKVRKAHQETFPALCQLGKYTTNNS 116
S +VRNDRNKKKKEVPKPECSESYTLTPEVGELIEKVRKAHQETFPALCQLGKYTTNNS
Sbjct: 154 SKESVRNDRNKKKKEVPKPECSESYTLTPEVGELIEKVRKAHQETFPALCQLGKYTTNNS 213
Query: 117 SEQRVSLDIDLWDKFSELSTKCIIKTVEFAKQLPGFTTLTIADQITLLKAACLDILILRI 176
SEQRVSLDIDLWDKFSELSTKCIIKTVEFAKQLPGFTTLTIADQITLLKAACLDILILRI
Sbjct: 214 SEQRVSLDIDLWDKFSELSTKCIIKTVEFAKQLPGFTTLTIADQITLLKAACLDILILRI 273
Query: 177 CTRYTPEQDTMTFSDGLTLNRTQMHNAGFGPLTDLVFAFANQLLPLEMDDAETGLLSAIC 236
CTRYTPEQDTMTFSDGLTLNRTQMHNAGFGPLTDLVFAFANQLLPLEMDDAETGLLSAIC
Sbjct: 274 CTRYTPEQDTMTFSDGLTLNRTQMHNAGFGPLTDLVFAFANQLLPLEMDDAETGLLSAIC 333
Query: 237 LICGDRQDLEQPDRVDMLQEPLLEALKVYVRKRRPSRPHMFPKMLMKITDLRSISAKGAE 296
LICGDRQDLEQPDRVDMLQEPLLEALKVYVRKRRPSRPHMFPKMLMKITDLRSISAKGAE
Sbjct: 334 LICGDRQDLEQPDRVDMLQEPLLEALKVYVRKRRPSRPHMFPKMLMKITDLRSISAKGAE 393
Query: 297 RVITLKMEIPGSMPPLIQEMLENSEGLDTLSGQPGGGGRDGGGLAPPPGSCSPSLSPSSN 356
RVITLKMEIPGSMPPLIQEMLENSEGLDTLSGQPGGGGRDGGGLAPPPGSCSPSLSPSSN
Sbjct: 394 RVITLKMEIPGSMPPLIQEMLENSEGLDTLSGQPGGGGRDGGGLAPPPGSCSPSLSPSSN 453
Query: 357 RSSPATHSP 365
RSSPATHSP
Sbjct: 454 RSSPATHSP 462
Score = 140 bits (353), Expect = 2e-33
Identities = 63/75 (84%), Positives = 67/75 (89%)
Query: 1 MASNSSSCPTPGGGHLNGYPVPPYAFFFPPMLGGLSPPGALTTLQHQLPVSGYSTPSPAT 60
MASNSSSCPTPGGGHLNGYPVPPYAFFFPPMLGGLSPPGALTTLQHQLPVSGYSTPSPAT
Sbjct: 1 MASNSSSCPTPGGGHLNGYPVPPYAFFFPPMLGGLSPPGALTTLQHQLPVSGYSTPSPAT 60
Query: 61 VRNDRNKKKKEVPKP 75
+ + ++ VP P
Sbjct: 61 IETQSSSSEEIVPSP 75
>gi|67459914 retinoic acid receptor, alpha isoform 2 [Homo sapiens]
Length = 457
Score = 615 bits (1585), Expect = e-176
Identities = 306/309 (99%), Positives = 307/309 (99%)
Query: 57 SPATVRNDRNKKKKEVPKPECSESYTLTPEVGELIEKVRKAHQETFPALCQLGKYTTNNS 116
S +VRNDRNKKKKEVPKPECSESYTLTPEVGELIEKVRKAHQETFPALCQLGKYTTNNS
Sbjct: 149 SKESVRNDRNKKKKEVPKPECSESYTLTPEVGELIEKVRKAHQETFPALCQLGKYTTNNS 208
Query: 117 SEQRVSLDIDLWDKFSELSTKCIIKTVEFAKQLPGFTTLTIADQITLLKAACLDILILRI 176
SEQRVSLDIDLWDKFSELSTKCIIKTVEFAKQLPGFTTLTIADQITLLKAACLDILILRI
Sbjct: 209 SEQRVSLDIDLWDKFSELSTKCIIKTVEFAKQLPGFTTLTIADQITLLKAACLDILILRI 268
Query: 177 CTRYTPEQDTMTFSDGLTLNRTQMHNAGFGPLTDLVFAFANQLLPLEMDDAETGLLSAIC 236
CTRYTPEQDTMTFSDGLTLNRTQMHNAGFGPLTDLVFAFANQLLPLEMDDAETGLLSAIC
Sbjct: 269 CTRYTPEQDTMTFSDGLTLNRTQMHNAGFGPLTDLVFAFANQLLPLEMDDAETGLLSAIC 328
Query: 237 LICGDRQDLEQPDRVDMLQEPLLEALKVYVRKRRPSRPHMFPKMLMKITDLRSISAKGAE 296
LICGDRQDLEQPDRVDMLQEPLLEALKVYVRKRRPSRPHMFPKMLMKITDLRSISAKGAE
Sbjct: 329 LICGDRQDLEQPDRVDMLQEPLLEALKVYVRKRRPSRPHMFPKMLMKITDLRSISAKGAE 388
Query: 297 RVITLKMEIPGSMPPLIQEMLENSEGLDTLSGQPGGGGRDGGGLAPPPGSCSPSLSPSSN 356
RVITLKMEIPGSMPPLIQEMLENSEGLDTLSGQPGGGGRDGGGLAPPPGSCSPSLSPSSN
Sbjct: 389 RVITLKMEIPGSMPPLIQEMLENSEGLDTLSGQPGGGGRDGGGLAPPPGSCSPSLSPSSN 448
Query: 357 RSSPATHSP 365
RSSPATHSP
Sbjct: 449 RSSPATHSP 457
>gi|4506419 retinoic acid receptor, alpha isoform 1 [Homo sapiens]
Length = 462
Score = 615 bits (1585), Expect = e-176
Identities = 306/309 (99%), Positives = 307/309 (99%)
Query: 57 SPATVRNDRNKKKKEVPKPECSESYTLTPEVGELIEKVRKAHQETFPALCQLGKYTTNNS 116
S +VRNDRNKKKKEVPKPECSESYTLTPEVGELIEKVRKAHQETFPALCQLGKYTTNNS
Sbjct: 154 SKESVRNDRNKKKKEVPKPECSESYTLTPEVGELIEKVRKAHQETFPALCQLGKYTTNNS 213
Query: 117 SEQRVSLDIDLWDKFSELSTKCIIKTVEFAKQLPGFTTLTIADQITLLKAACLDILILRI 176
SEQRVSLDIDLWDKFSELSTKCIIKTVEFAKQLPGFTTLTIADQITLLKAACLDILILRI
Sbjct: 214 SEQRVSLDIDLWDKFSELSTKCIIKTVEFAKQLPGFTTLTIADQITLLKAACLDILILRI 273
Query: 177 CTRYTPEQDTMTFSDGLTLNRTQMHNAGFGPLTDLVFAFANQLLPLEMDDAETGLLSAIC 236
CTRYTPEQDTMTFSDGLTLNRTQMHNAGFGPLTDLVFAFANQLLPLEMDDAETGLLSAIC
Sbjct: 274 CTRYTPEQDTMTFSDGLTLNRTQMHNAGFGPLTDLVFAFANQLLPLEMDDAETGLLSAIC 333
Query: 237 LICGDRQDLEQPDRVDMLQEPLLEALKVYVRKRRPSRPHMFPKMLMKITDLRSISAKGAE 296
LICGDRQDLEQPDRVDMLQEPLLEALKVYVRKRRPSRPHMFPKMLMKITDLRSISAKGAE
Sbjct: 334 LICGDRQDLEQPDRVDMLQEPLLEALKVYVRKRRPSRPHMFPKMLMKITDLRSISAKGAE 393
Query: 297 RVITLKMEIPGSMPPLIQEMLENSEGLDTLSGQPGGGGRDGGGLAPPPGSCSPSLSPSSN 356
RVITLKMEIPGSMPPLIQEMLENSEGLDTLSGQPGGGGRDGGGLAPPPGSCSPSLSPSSN
Sbjct: 394 RVITLKMEIPGSMPPLIQEMLENSEGLDTLSGQPGGGGRDGGGLAPPPGSCSPSLSPSSN 453
Query: 357 RSSPATHSP 365
RSSPATHSP
Sbjct: 454 RSSPATHSP 462
Score = 140 bits (353), Expect = 2e-33
Identities = 63/75 (84%), Positives = 67/75 (89%)
Query: 1 MASNSSSCPTPGGGHLNGYPVPPYAFFFPPMLGGLSPPGALTTLQHQLPVSGYSTPSPAT 60
MASNSSSCPTPGGGHLNGYPVPPYAFFFPPMLGGLSPPGALTTLQHQLPVSGYSTPSPAT
Sbjct: 1 MASNSSSCPTPGGGHLNGYPVPPYAFFFPPMLGGLSPPGALTTLQHQLPVSGYSTPSPAT 60
Query: 61 VRNDRNKKKKEVPKP 75
+ + ++ VP P
Sbjct: 61 IETQSSSSEEIVPSP 75
>gi|14916494 retinoic acid receptor, beta isoform 1 [Homo sapiens]
Length = 448
Score = 479 bits (1234), Expect = e-135
Identities = 241/309 (77%), Positives = 266/309 (86%), Gaps = 10/309 (3%)
Query: 57 SPATVRNDRNKKKKEVPKPECSESYTLTPEVGELIEKVRKAHQETFPALCQLGKYTTNNS 116
S +VRNDRNKKKKE K EC+ESY +T E+ +L EK+RKAHQETFP+LCQLGKYTTN+S
Sbjct: 147 SKESVRNDRNKKKKETSKQECTESYEMTAELDDLTEKIRKAHQETFPSLCQLGKYTTNSS 206
Query: 117 SEQRVSLDIDLWDKFSELSTKCIIKTVEFAKQLPGFTTLTIADQITLLKAACLDILILRI 176
++ RV LD+ LWDKFSEL+TKCIIK VEFAK+LPGFT LTIADQITLLKAACLDILILRI
Sbjct: 207 ADHRVRLDLGLWDKFSELATKCIIKIVEFAKRLPGFTGLTIADQITLLKAACLDILILRI 266
Query: 177 CTRYTPEQDTMTFSDGLTLNRTQMHNAGFGPLTDLVFAFANQLLPLEMDDAETGLLSAIC 236
CTRYTPEQDTMTFSDGLTLNRTQMHNAGFGPLTDLVF FANQLLPLEMDD ETGLLSAIC
Sbjct: 267 CTRYTPEQDTMTFSDGLTLNRTQMHNAGFGPLTDLVFTFANQLLPLEMDDTETGLLSAIC 326
Query: 237 LICGDRQDLEQPDRVDMLQEPLLEALKVYVRKRRPSRPHMFPKMLMKITDLRSISAKGAE 296
LICGDRQDLE+P +VD LQEPLLEALK+Y+RKRRPS+PHMFPK+LMKITDLRSISAKGAE
Sbjct: 327 LICGDRQDLEEPTKVDKLQEPLLEALKIYIRKRRPSKPHMFPKILMKITDLRSISAKGAE 386
Query: 297 RVITLKMEIPGSMPPLIQEMLENSEGLDTLSGQPGGGGRDGGGLAPPPGSCSPSLSPSSN 356
RVITLKMEIPGSMPPLIQEMLENSEG + L+ G + SPS+SPSS
Sbjct: 387 RVITLKMEIPGSMPPLIQEMLENSEGHEPLTPSSSGNTAEH----------SPSISPSSV 436
Query: 357 RSSPATHSP 365
+S + SP
Sbjct: 437 ENSGVSQSP 445
>gi|7706625 retinoic acid receptor, beta isoform 2 [Homo sapiens]
Length = 336
Score = 479 bits (1234), Expect = e-135
Identities = 241/309 (77%), Positives = 266/309 (86%), Gaps = 10/309 (3%)
Query: 57 SPATVRNDRNKKKKEVPKPECSESYTLTPEVGELIEKVRKAHQETFPALCQLGKYTTNNS 116
S +VRNDRNKKKKE K EC+ESY +T E+ +L EK+RKAHQETFP+LCQLGKYTTN+S
Sbjct: 35 SKESVRNDRNKKKKETSKQECTESYEMTAELDDLTEKIRKAHQETFPSLCQLGKYTTNSS 94
Query: 117 SEQRVSLDIDLWDKFSELSTKCIIKTVEFAKQLPGFTTLTIADQITLLKAACLDILILRI 176
++ RV LD+ LWDKFSEL+TKCIIK VEFAK+LPGFT LTIADQITLLKAACLDILILRI
Sbjct: 95 ADHRVRLDLGLWDKFSELATKCIIKIVEFAKRLPGFTGLTIADQITLLKAACLDILILRI 154
Query: 177 CTRYTPEQDTMTFSDGLTLNRTQMHNAGFGPLTDLVFAFANQLLPLEMDDAETGLLSAIC 236
CTRYTPEQDTMTFSDGLTLNRTQMHNAGFGPLTDLVF FANQLLPLEMDD ETGLLSAIC
Sbjct: 155 CTRYTPEQDTMTFSDGLTLNRTQMHNAGFGPLTDLVFTFANQLLPLEMDDTETGLLSAIC 214
Query: 237 LICGDRQDLEQPDRVDMLQEPLLEALKVYVRKRRPSRPHMFPKMLMKITDLRSISAKGAE 296
LICGDRQDLE+P +VD LQEPLLEALK+Y+RKRRPS+PHMFPK+LMKITDLRSISAKGAE
Sbjct: 215 LICGDRQDLEEPTKVDKLQEPLLEALKIYIRKRRPSKPHMFPKILMKITDLRSISAKGAE 274
Query: 297 RVITLKMEIPGSMPPLIQEMLENSEGLDTLSGQPGGGGRDGGGLAPPPGSCSPSLSPSSN 356
RVITLKMEIPGSMPPLIQEMLENSEG + L+ G + SPS+SPSS
Sbjct: 275 RVITLKMEIPGSMPPLIQEMLENSEGHEPLTPSSSGNTAEH----------SPSISPSSV 324
Query: 357 RSSPATHSP 365
+S + SP
Sbjct: 325 ENSGVSQSP 333
>gi|112181200 retinoic acid receptor, gamma isoform 2 [Homo sapiens]
Length = 443
Score = 445 bits (1144), Expect = e-125
Identities = 224/298 (75%), Positives = 250/298 (83%), Gaps = 11/298 (3%)
Query: 57 SPATVRNDRNKKKKEVPKPECSESYTLTPEVGELIEKVRKAHQETFPALCQLGKYTTNNS 116
S VRNDRNKKKKEV + +SY L+P++ ELI KV KAHQETFP+LCQLGKYTTN+S
Sbjct: 145 SKEAVRNDRNKKKKEVKEEGSPDSYELSPQLEELITKVSKAHQETFPSLCQLGKYTTNSS 204
Query: 117 SEQRVSLDIDLWDKFSELSTKCIIKTVEFAKQLPGFTTLTIADQITLLKAACLDILILRI 176
++ RV LD+ LWDKFSEL+TKCIIK VEFAK+LPGFT L+IADQITLLKAACLDIL+LRI
Sbjct: 205 ADHRVQLDLGLWDKFSELATKCIIKIVEFAKRLPGFTGLSIADQITLLKAACLDILMLRI 264
Query: 177 CTRYTPEQDTMTFSDGLTLNRTQMHNAGFGPLTDLVFAFANQLLPLEMDDAETGLLSAIC 236
CTRYTPEQDTMTFSDGLTLNRTQMHNAGFGPLTDLVFAFA QLLPLEMDD ETGLLSAIC
Sbjct: 265 CTRYTPEQDTMTFSDGLTLNRTQMHNAGFGPLTDLVFAFAGQLLPLEMDDTETGLLSAIC 324
Query: 237 LICGDRQDLEQPDRVDMLQEPLLEALKVYVRKRRPSRPHMFPKMLMKITDLRSISAKGAE 296
LICGDR DLE+P++VD LQEPLLEAL++Y R+RRPS+P+MFP+MLMKITDLR IS KGAE
Sbjct: 325 LICGDRMDLEEPEKVDKLQEPLLEALRLYARRRRPSQPYMFPRMLMKITDLRGISTKGAE 384
Query: 297 RVITLKMEIPGSMPPLIQEMLENSEGLDTLSGQPG-----------GGGRDGGGLAPP 343
R ITLKMEIPG MPPLI+EMLEN E + S QPG GG+ GGL P
Sbjct: 385 RAITLKMEIPGPMPPLIREMLENPEMFEDDSSQPGPHPNASSEDEVPGGQGKGGLKSP 442
>gi|4506423 retinoic acid receptor, gamma isoform 1 [Homo sapiens]
Length = 454
Score = 445 bits (1144), Expect = e-125
Identities = 224/298 (75%), Positives = 250/298 (83%), Gaps = 11/298 (3%)
Query: 57 SPATVRNDRNKKKKEVPKPECSESYTLTPEVGELIEKVRKAHQETFPALCQLGKYTTNNS 116
S VRNDRNKKKKEV + +SY L+P++ ELI KV KAHQETFP+LCQLGKYTTN+S
Sbjct: 156 SKEAVRNDRNKKKKEVKEEGSPDSYELSPQLEELITKVSKAHQETFPSLCQLGKYTTNSS 215
Query: 117 SEQRVSLDIDLWDKFSELSTKCIIKTVEFAKQLPGFTTLTIADQITLLKAACLDILILRI 176
++ RV LD+ LWDKFSEL+TKCIIK VEFAK+LPGFT L+IADQITLLKAACLDIL+LRI
Sbjct: 216 ADHRVQLDLGLWDKFSELATKCIIKIVEFAKRLPGFTGLSIADQITLLKAACLDILMLRI 275
Query: 177 CTRYTPEQDTMTFSDGLTLNRTQMHNAGFGPLTDLVFAFANQLLPLEMDDAETGLLSAIC 236
CTRYTPEQDTMTFSDGLTLNRTQMHNAGFGPLTDLVFAFA QLLPLEMDD ETGLLSAIC
Sbjct: 276 CTRYTPEQDTMTFSDGLTLNRTQMHNAGFGPLTDLVFAFAGQLLPLEMDDTETGLLSAIC 335
Query: 237 LICGDRQDLEQPDRVDMLQEPLLEALKVYVRKRRPSRPHMFPKMLMKITDLRSISAKGAE 296
LICGDR DLE+P++VD LQEPLLEAL++Y R+RRPS+P+MFP+MLMKITDLR IS KGAE
Sbjct: 336 LICGDRMDLEEPEKVDKLQEPLLEALRLYARRRRPSQPYMFPRMLMKITDLRGISTKGAE 395
Query: 297 RVITLKMEIPGSMPPLIQEMLENSEGLDTLSGQPG-----------GGGRDGGGLAPP 343
R ITLKMEIPG MPPLI+EMLEN E + S QPG GG+ GGL P
Sbjct: 396 RAITLKMEIPGPMPPLIREMLENPEMFEDDSSQPGPHPNASSEDEVPGGQGKGGLKSP 453
>gi|40806160 thyroid hormone receptor, alpha isoform 1 [Homo
sapiens]
Length = 410
Score = 163 bits (412), Expect = 3e-40
Identities = 93/272 (34%), Positives = 147/272 (54%), Gaps = 11/272 (4%)
Query: 61 VRNDRNKKKKEVPKPECSESYTLTPEVGELIEKVRKAHQETFPALC---QLGKYTTNNSS 117
+ +R +++KE + TPE +LI +AH+ T Q K+ ++
Sbjct: 138 IEQNRERRRKEEMIRSLQQRPEPTPEEWDLIHIATEAHRSTNAQGSHWKQRRKFLPDDIG 197
Query: 118 EQRV-------SLDIDLWDKFSELSTKCIIKTVEFAKQLPGFTTLTIADQITLLKAACLD 170
+ + +D++ + +F+++ T I + V+FAK+LP F+ L DQI LLK C++
Sbjct: 198 QSPIVSMPDGDKVDLEAFSEFTKIITPAITRVVDFAKKLPMFSELPCEDQIILLKGCCME 257
Query: 171 ILILRICTRYTPEQDTMTFSDGLTLNRTQMHNAGFGPLTDLVFAFANQLLPLEMDDAETG 230
I+ LR RY PE DT+T S + + R Q+ N G G ++D +F L +DD E
Sbjct: 258 IMSLRAAVRYDPESDTLTLSGEMAVKREQLKNGGLGVVSDAIFELGKSLSAFNLDDTEVA 317
Query: 231 LLSAICLICGDRQDLEQPDRVDMLQEPLLEALKVYVRKRRPSRPHMFPKMLMKITDLRSI 290
LL A+ L+ DR L D+++ QE L A + YV R+ + PH +PK+LMK+TDLR I
Sbjct: 318 LLQAVLLMSTDRSGLLCVDKIEKSQEAYLLAFEHYVNHRKHNIPHFWPKLLMKVTDLRMI 377
Query: 291 SAKGAERVITLKMEIPGSM-PPLIQEMLENSE 321
A A R + +K+E P + PPL E+ E+ E
Sbjct: 378 GACHASRFLHMKVECPTELFPPLFLEVFEDQE 409
>gi|189491771 thyroid hormone receptor, beta [Homo sapiens]
Length = 461
Score = 150 bits (380), Expect = 1e-36
Identities = 88/270 (32%), Positives = 141/270 (52%), Gaps = 11/270 (4%)
Query: 61 VRNDRNKKKKEVPKPECSESYTLTPEVGELIEKVRKAHQETFPALC---QLGKYTTNNSS 117
+ +R K+++E + T E ELI+ V +AH T Q K+ +
Sbjct: 192 IEENREKRRREELQKSIGHKPEPTDEEWELIKTVTEAHVATNAQGSHWKQKRKFLPEDIG 251
Query: 118 EQRV-------SLDIDLWDKFSELSTKCIIKTVEFAKQLPGFTTLTIADQITLLKAACLD 170
+ + +D++ + F+++ T I + V+FAK+LP F L DQI LLK C++
Sbjct: 252 QAPIVNAPEGGKVDLEAFSHFTKIITPAITRVVDFAKKLPMFCELPCEDQIILLKGCCME 311
Query: 171 ILILRICTRYTPEQDTMTFSDGLTLNRTQMHNAGFGPLTDLVFAFANQLLPLEMDDAETG 230
I+ LR RY PE +T+T + + + R Q+ N G G ++D +F L +DD E
Sbjct: 312 IMSLRAAVRYDPESETLTLNGEMAVTRGQLKNGGLGVVSDAIFDLGMSLSSFNLDDTEVA 371
Query: 231 LLSAICLICGDRQDLEQPDRVDMLQEPLLEALKVYVRKRRPSRPHMFPKMLMKITDLRSI 290
LL A+ L+ DR L +R++ Q+ L A + Y+ R+ H +PK+LMK+TDLR I
Sbjct: 372 LLQAVLLMSSDRPGLACVERIEKYQDSFLLAFEHYINYRKHHVTHFWPKLLMKVTDLRMI 431
Query: 291 SAKGAERVITLKMEIPGSM-PPLIQEMLEN 319
A A R + +K+E P + PPL E+ E+
Sbjct: 432 GACHASRFLHMKVECPTELFPPLFLEVFED 461
>gi|189491769 thyroid hormone receptor, beta [Homo sapiens]
Length = 461
Score = 150 bits (380), Expect = 1e-36
Identities = 88/270 (32%), Positives = 141/270 (52%), Gaps = 11/270 (4%)
Query: 61 VRNDRNKKKKEVPKPECSESYTLTPEVGELIEKVRKAHQETFPALC---QLGKYTTNNSS 117
+ +R K+++E + T E ELI+ V +AH T Q K+ +
Sbjct: 192 IEENREKRRREELQKSIGHKPEPTDEEWELIKTVTEAHVATNAQGSHWKQKRKFLPEDIG 251
Query: 118 EQRV-------SLDIDLWDKFSELSTKCIIKTVEFAKQLPGFTTLTIADQITLLKAACLD 170
+ + +D++ + F+++ T I + V+FAK+LP F L DQI LLK C++
Sbjct: 252 QAPIVNAPEGGKVDLEAFSHFTKIITPAITRVVDFAKKLPMFCELPCEDQIILLKGCCME 311
Query: 171 ILILRICTRYTPEQDTMTFSDGLTLNRTQMHNAGFGPLTDLVFAFANQLLPLEMDDAETG 230
I+ LR RY PE +T+T + + + R Q+ N G G ++D +F L +DD E
Sbjct: 312 IMSLRAAVRYDPESETLTLNGEMAVTRGQLKNGGLGVVSDAIFDLGMSLSSFNLDDTEVA 371
Query: 231 LLSAICLICGDRQDLEQPDRVDMLQEPLLEALKVYVRKRRPSRPHMFPKMLMKITDLRSI 290
LL A+ L+ DR L +R++ Q+ L A + Y+ R+ H +PK+LMK+TDLR I
Sbjct: 372 LLQAVLLMSSDRPGLACVERIEKYQDSFLLAFEHYINYRKHHVTHFWPKLLMKVTDLRMI 431
Query: 291 SAKGAERVITLKMEIPGSM-PPLIQEMLEN 319
A A R + +K+E P + PPL E+ E+
Sbjct: 432 GACHASRFLHMKVECPTELFPPLFLEVFED 461
>gi|40806162 thyroid hormone receptor, beta [Homo sapiens]
Length = 461
Score = 150 bits (380), Expect = 1e-36
Identities = 88/270 (32%), Positives = 141/270 (52%), Gaps = 11/270 (4%)
Query: 61 VRNDRNKKKKEVPKPECSESYTLTPEVGELIEKVRKAHQETFPALC---QLGKYTTNNSS 117
+ +R K+++E + T E ELI+ V +AH T Q K+ +
Sbjct: 192 IEENREKRRREELQKSIGHKPEPTDEEWELIKTVTEAHVATNAQGSHWKQKRKFLPEDIG 251
Query: 118 EQRV-------SLDIDLWDKFSELSTKCIIKTVEFAKQLPGFTTLTIADQITLLKAACLD 170
+ + +D++ + F+++ T I + V+FAK+LP F L DQI LLK C++
Sbjct: 252 QAPIVNAPEGGKVDLEAFSHFTKIITPAITRVVDFAKKLPMFCELPCEDQIILLKGCCME 311
Query: 171 ILILRICTRYTPEQDTMTFSDGLTLNRTQMHNAGFGPLTDLVFAFANQLLPLEMDDAETG 230
I+ LR RY PE +T+T + + + R Q+ N G G ++D +F L +DD E
Sbjct: 312 IMSLRAAVRYDPESETLTLNGEMAVTRGQLKNGGLGVVSDAIFDLGMSLSSFNLDDTEVA 371
Query: 231 LLSAICLICGDRQDLEQPDRVDMLQEPLLEALKVYVRKRRPSRPHMFPKMLMKITDLRSI 290
LL A+ L+ DR L +R++ Q+ L A + Y+ R+ H +PK+LMK+TDLR I
Sbjct: 372 LLQAVLLMSSDRPGLACVERIEKYQDSFLLAFEHYINYRKHHVTHFWPKLLMKVTDLRMI 431
Query: 291 SAKGAERVITLKMEIPGSM-PPLIQEMLEN 319
A A R + +K+E P + PPL E+ E+
Sbjct: 432 GACHASRFLHMKVECPTELFPPLFLEVFED 461
>gi|20127452 thyroid hormone receptor, alpha isoform 2 [Homo
sapiens]
Length = 490
Score = 137 bits (346), Expect = 1e-32
Identities = 81/246 (32%), Positives = 131/246 (53%), Gaps = 11/246 (4%)
Query: 61 VRNDRNKKKKEVPKPECSESYTLTPEVGELIEKVRKAHQETFPALC---QLGKYTTNNSS 117
+ +R +++KE + TPE +LI +AH+ T Q K+ ++
Sbjct: 138 IEQNRERRRKEEMIRSLQQRPEPTPEEWDLIHIATEAHRSTNAQGSHWKQRRKFLPDDIG 197
Query: 118 EQRV-------SLDIDLWDKFSELSTKCIIKTVEFAKQLPGFTTLTIADQITLLKAACLD 170
+ + +D++ + +F+++ T I + V+FAK+LP F+ L DQI LLK C++
Sbjct: 198 QSPIVSMPDGDKVDLEAFSEFTKIITPAITRVVDFAKKLPMFSELPCEDQIILLKGCCME 257
Query: 171 ILILRICTRYTPEQDTMTFSDGLTLNRTQMHNAGFGPLTDLVFAFANQLLPLEMDDAETG 230
I+ LR RY PE DT+T S + + R Q+ N G G ++D +F L +DD E
Sbjct: 258 IMSLRAAVRYDPESDTLTLSGEMAVKREQLKNGGLGVVSDAIFELGKSLSAFNLDDTEVA 317
Query: 231 LLSAICLICGDRQDLEQPDRVDMLQEPLLEALKVYVRKRRPSRPHMFPKMLMKITDLR-S 289
LL A+ L+ DR L D+++ QE L A + YV R+ + PH +PK+LMK +++ S
Sbjct: 318 LLQAVLLMSTDRSGLLCVDKIEKSQEAYLLAFEHYVNHRKHNIPHFWPKLLMKEREVQSS 377
Query: 290 ISAKGA 295
I KGA
Sbjct: 378 ILYKGA 383
>gi|85362735 nuclear receptor subfamily 1, group H, member 2 [Homo
sapiens]
Length = 461
Score = 133 bits (335), Expect = 2e-31
Identities = 73/192 (38%), Positives = 116/192 (60%), Gaps = 2/192 (1%)
Query: 131 FSELSTKCIIKTVEFAKQLPGFTTLTIADQITLLKAACLDILILRICTRYTPEQDTMTFS 190
F+EL+ + + V+FAKQ+PGF L DQI LLKA+ ++I++L RY E + +TF
Sbjct: 271 FTELAIISVQEIVDFAKQVPGFLQLGREDQIALLKASTIEIMLLETARRYNHETECITFL 330
Query: 191 DGLTLNRTQMHNAGFG-PLTDLVFAFANQLLPLEMDDAETGLLSAICLICGDRQDLEQPD 249
T ++ H AG + +F F+ + L +DDAE LL AI + DR ++++P
Sbjct: 331 KDFTYSKDDFHRAGLQVEFINPIFEFSRAMRRLGLDDAEYALLIAINIFSADRPNVQEPG 390
Query: 250 RVDMLQEPLLEALKVYVRKRRPSRPHMFPKMLMKITDLRSISAKGAERVITLKMEIPGSM 309
RV+ LQ+P +EAL Y R +RP FP+MLMK+ LR++S+ +E+V L+++ +
Sbjct: 391 RVEALQQPYVEALLSYTRIKRPQDQLRFPRMLMKLVSLRTLSSVHSEQVFALRLQ-DKKL 449
Query: 310 PPLIQEMLENSE 321
PPL+ E+ + E
Sbjct: 450 PPLLSEIWDVHE 461
>gi|224177493 nuclear receptor subfamily 1, group D, member 2
isoform 2 [Homo sapiens]
Length = 504
Score = 127 bits (319), Expect = 2e-29
Identities = 60/178 (33%), Positives = 108/178 (60%)
Query: 126 DLWDKFSELSTKCIIKTVEFAKQLPGFTTLTIADQITLLKAACLDILILRICTRYTPEQD 185
++W++FS T + + VEFAK++PGF L+ DQ+ LLKA ++L++R + + ++
Sbjct: 325 EIWEEFSMSFTPAVKEVVEFAKRIPGFRDLSQHDQVNLLKAGTFEVLMVRFASLFDAKER 384
Query: 186 TMTFSDGLTLNRTQMHNAGFGPLTDLVFAFANQLLPLEMDDAETGLLSAICLICGDRQDL 245
T+TF G + +H+ G G L + +F F+ +L L++ D E L +A+ L+ DR +
Sbjct: 385 TVTFLSGKKYSVDDLHSMGAGDLLNSMFEFSEKLNALQLSDEEMSLFTAVVLVSADRSGI 444
Query: 246 EQPDRVDMLQEPLLEALKVYVRKRRPSRPHMFPKMLMKITDLRSISAKGAERVITLKM 303
E + V+ LQE L+ AL+ + K P+ +F K+L+K+ DLRS++ +E ++ K+
Sbjct: 445 ENVNSVEALQETLIRALRTLIMKNHPNEASIFTKLLLKLPDLRSLNNMHSEELLAFKV 502
>gi|224177491 nuclear receptor subfamily 1, group D, member 2
isoform 1 [Homo sapiens]
Length = 579
Score = 127 bits (319), Expect = 2e-29
Identities = 60/178 (33%), Positives = 108/178 (60%)
Query: 126 DLWDKFSELSTKCIIKTVEFAKQLPGFTTLTIADQITLLKAACLDILILRICTRYTPEQD 185
++W++FS T + + VEFAK++PGF L+ DQ+ LLKA ++L++R + + ++
Sbjct: 400 EIWEEFSMSFTPAVKEVVEFAKRIPGFRDLSQHDQVNLLKAGTFEVLMVRFASLFDAKER 459
Query: 186 TMTFSDGLTLNRTQMHNAGFGPLTDLVFAFANQLLPLEMDDAETGLLSAICLICGDRQDL 245
T+TF G + +H+ G G L + +F F+ +L L++ D E L +A+ L+ DR +
Sbjct: 460 TVTFLSGKKYSVDDLHSMGAGDLLNSMFEFSEKLNALQLSDEEMSLFTAVVLVSADRSGI 519
Query: 246 EQPDRVDMLQEPLLEALKVYVRKRRPSRPHMFPKMLMKITDLRSISAKGAERVITLKM 303
E + V+ LQE L+ AL+ + K P+ +F K+L+K+ DLRS++ +E ++ K+
Sbjct: 520 ENVNSVEALQETLIRALRTLIMKNHPNEASIFTKLLLKLPDLRSLNNMHSEELLAFKV 577
>gi|194294519 nuclear receptor subfamily 1, group H, member 3
isoform c [Homo sapiens]
Length = 402
Score = 123 bits (308), Expect = 3e-28
Identities = 68/192 (35%), Positives = 112/192 (58%), Gaps = 2/192 (1%)
Query: 131 FSELSTKCIIKTVEFAKQLPGFTTLTIADQITLLKAACLDILILRICTRYTPEQDTMTFS 190
F+EL+ + + V+FAKQLPGF L+ DQI LLK + +++++L RY P +++TF
Sbjct: 212 FTELAIVSVQEIVDFAKQLPGFLQLSREDQIALLKTSAIEVMLLETSRRYNPGSESITFL 271
Query: 191 DGLTLNRTQMHNAGFG-PLTDLVFAFANQLLPLEMDDAETGLLSAICLICGDRQDLEQPD 249
+ NR AG + +F F+ + L+++DAE LL AI + DR +++
Sbjct: 272 KDFSYNREDFAKAGLQVEFINPIFEFSRAMNELQLNDAEFALLIAISIFSADRPNVQDQL 331
Query: 250 RVDMLQEPLLEALKVYVRKRRPSRPHMFPKMLMKITDLRSISAKGAERVITLKMEIPGSM 309
+V+ LQ +EAL YV P MFP+MLMK+ LR++S+ +E+V L+++ +
Sbjct: 332 QVERLQHTYVEALHAYVSIHHPHDRLMFPRMLMKLVSLRTLSSVHSEQVFALRLQ-DKKL 390
Query: 310 PPLIQEMLENSE 321
PPL+ E+ + E
Sbjct: 391 PPLLSEIWDVHE 402
>gi|194294517 nuclear receptor subfamily 1, group H, member 3
isoform a [Homo sapiens]
Length = 447
Score = 123 bits (308), Expect = 3e-28
Identities = 68/192 (35%), Positives = 112/192 (58%), Gaps = 2/192 (1%)
Query: 131 FSELSTKCIIKTVEFAKQLPGFTTLTIADQITLLKAACLDILILRICTRYTPEQDTMTFS 190
F+EL+ + + V+FAKQLPGF L+ DQI LLK + +++++L RY P +++TF
Sbjct: 257 FTELAIVSVQEIVDFAKQLPGFLQLSREDQIALLKTSAIEVMLLETSRRYNPGSESITFL 316
Query: 191 DGLTLNRTQMHNAGFG-PLTDLVFAFANQLLPLEMDDAETGLLSAICLICGDRQDLEQPD 249
+ NR AG + +F F+ + L+++DAE LL AI + DR +++
Sbjct: 317 KDFSYNREDFAKAGLQVEFINPIFEFSRAMNELQLNDAEFALLIAISIFSADRPNVQDQL 376
Query: 250 RVDMLQEPLLEALKVYVRKRRPSRPHMFPKMLMKITDLRSISAKGAERVITLKMEIPGSM 309
+V+ LQ +EAL YV P MFP+MLMK+ LR++S+ +E+V L+++ +
Sbjct: 377 QVERLQHTYVEALHAYVSIHHPHDRLMFPRMLMKLVSLRTLSSVHSEQVFALRLQ-DKKL 435
Query: 310 PPLIQEMLENSE 321
PPL+ E+ + E
Sbjct: 436 PPLLSEIWDVHE 447
>gi|13430848 nuclear receptor subfamily 1, group D, member 1 [Homo
sapiens]
Length = 614
Score = 121 bits (303), Expect = 1e-27
Identities = 60/179 (33%), Positives = 104/179 (58%)
Query: 126 DLWDKFSELSTKCIIKTVEFAKQLPGFTTLTIADQITLLKAACLDILILRICTRYTPEQD 185
++W+ FS T + + VEFAK +PGF L+ DQ+TLLKA ++L++R + + +
Sbjct: 434 EIWEDFSMSFTPAVREVVEFAKHIPGFRDLSQHDQVTLLKAGTFEVLMVRFASLFNVKDQ 493
Query: 186 TMTFSDGLTLNRTQMHNAGFGPLTDLVFAFANQLLPLEMDDAETGLLSAICLICGDRQDL 245
T+ F T + ++ G G L +F F+ +L L + + E GL +A+ L+ DR +
Sbjct: 494 TVMFLSRTTYSLQELGAMGMGDLLSAMFDFSEKLNSLALTEEELGLFTAVVLVSADRSGM 553
Query: 246 EQPDRVDMLQEPLLEALKVYVRKRRPSRPHMFPKMLMKITDLRSISAKGAERVITLKME 304
E V+ LQE LL AL+ V K RP F K+L+K+ DLR+++ +E++++ +++
Sbjct: 554 ENSASVEQLQETLLRALRALVLKNRPLETSRFTKLLLKLPDLRTLNNMHSEKLLSFRVD 612
>gi|5902068 retinoid X receptor, gamma isoform a [Homo sapiens]
Length = 463
Score = 108 bits (270), Expect = 8e-24
Identities = 67/229 (29%), Positives = 114/229 (49%), Gaps = 8/229 (3%)
Query: 91 IEKVRKAHQETFPALCQLGKYTTNNSSEQRVSLDIDLWDKFSELSTKCIIKTVEFAKQLP 150
+E++ +A P G NS+ V+ + K + VE+AK++P
Sbjct: 236 VERILEAELAVEPKTESYGDMNMENSTNDPVT-------NICHAADKQLFTLVEWAKRIP 288
Query: 151 GFTTLTIADQITLLKAACLDILILRICTRYTPEQDTMTFSDGLTLNRTQMHNAGFGPLTD 210
F+ LT+ DQ+ LL+A ++LI R QD + + GL ++R+ H+AG G + D
Sbjct: 289 HFSDLTLEDQVILLRAGWNELLIASFSHRSVSVQDGILLATGLHVHRSSAHSAGVGSIFD 348
Query: 211 LVFA-FANQLLPLEMDDAETGLLSAICLICGDRQDLEQPDRVDMLQEPLLEALKVYVRKR 269
V +++ ++MD +E G L AI L D + L P V+ L+E + L+ Y +++
Sbjct: 349 RVLTELVSKMKDMQMDKSELGCLRAIVLFNPDAKGLSNPSEVETLREKVYATLEAYTKQK 408
Query: 270 RPSRPHMFPKMLMKITDLRSISAKGAERVITLKMEIPGSMPPLIQEMLE 318
P +P F K+L+++ LRSI K E + K+ + + EMLE
Sbjct: 409 YPEQPGRFAKLLLRLPALRSIGLKCLEHLFFFKLIGDTPIDTFLMEMLE 457
>gi|4506755 retinoid X receptor, alpha [Homo sapiens]
Length = 462
Score = 99.4 bits (246), Expect = 5e-21
Identities = 58/187 (31%), Positives = 99/187 (52%), Gaps = 1/187 (0%)
Query: 133 ELSTKCIIKTVEFAKQLPGFTTLTIADQITLLKAACLDILILRICTRYTPEQDTMTFSDG 192
+ + K + VE+AK++P F+ L + DQ+ LL+A ++LI R +D + + G
Sbjct: 270 QAADKQLFTLVEWAKRIPHFSELPLDDQVILLRAGWNELLIASFSHRSIAVKDGILLATG 329
Query: 193 LTLNRTQMHNAGFGPLTDLVFA-FANQLLPLEMDDAETGLLSAICLICGDRQDLEQPDRV 251
L ++R H+AG G + D V +++ ++MD E G L AI L D + L P V
Sbjct: 330 LHVHRNSAHSAGVGAIFDRVLTELVSKMRDMQMDKTELGCLRAIVLFNPDSKGLSNPAEV 389
Query: 252 DMLQEPLLEALKVYVRKRRPSRPHMFPKMLMKITDLRSISAKGAERVITLKMEIPGSMPP 311
+ L+E + +L+ Y + + P +P F K+L+++ LRSI K E + K+ +
Sbjct: 390 EALREKVYASLEAYCKHKYPEQPGRFAKLLLRLPALRSIGLKCLEHLFFFKLIGDTPIDT 449
Query: 312 LIQEMLE 318
+ EMLE
Sbjct: 450 FLMEMLE 456
>gi|11415052 retinoid X receptor, beta [Homo sapiens]
Length = 533
Score = 98.6 bits (244), Expect = 8e-21
Identities = 57/187 (30%), Positives = 100/187 (53%), Gaps = 1/187 (0%)
Query: 133 ELSTKCIIKTVEFAKQLPGFTTLTIADQITLLKAACLDILILRICTRYTPEQDTMTFSDG 192
+ + K + VE+AK++P F++L + DQ+ LL+A ++LI R +D + + G
Sbjct: 341 QAADKQLFTLVEWAKRIPHFSSLPLDDQVILLRAGWNELLIASFSHRSIDVRDGILLATG 400
Query: 193 LTLNRTQMHNAGFGPLTDLVFA-FANQLLPLEMDDAETGLLSAICLICGDRQDLEQPDRV 251
L ++R H+AG G + D V +++ + MD E G L AI L D + L P V
Sbjct: 401 LHVHRNSAHSAGVGAIFDRVLTELVSKMRDMRMDKTELGCLRAIILFNPDAKGLSNPSEV 460
Query: 252 DMLQEPLLEALKVYVRKRRPSRPHMFPKMLMKITDLRSISAKGAERVITLKMEIPGSMPP 311
++L+E + +L+ Y +++ P + F K+L+++ LRSI K E + K+ +
Sbjct: 461 EVLREKVYASLETYCKQKYPEQQGRFAKLLLRLPALRSIGLKCLEHLFFFKLIGDTPIDT 520
Query: 312 LIQEMLE 318
+ EMLE
Sbjct: 521 FLMEMLE 527
>gi|5453822 nuclear receptor subfamily 4, group A, member 2 [Homo
sapiens]
Length = 598
Score = 96.7 bits (239), Expect = 3e-20
Identities = 75/271 (27%), Positives = 140/271 (51%), Gaps = 12/271 (4%)
Query: 61 VRNDRNKKKK-EVP-KPECSESYTLTPEVGELIEKVRKAHQETFPALCQLGKYTTNNSSE 118
VR D K ++ +P KP+ + + LI + +AH ++ PA+ L + +
Sbjct: 333 VRTDSLKGRRGRLPSKPKSPQEPSPPSPPVSLISALVRAHVDSNPAMTSLDYSRFQANPD 392
Query: 119 QRVSLD-IDLWDKFSELSTKCIIKTVEFAKQLPGFTTLTIADQITLLKAACLDILILRIC 177
++S D +F +L T + +A+++PGF L ADQ L ++A L++ +LR+
Sbjct: 393 YQMSGDDTQHIQQFYDLLTGSMEIIRGWAEKIPGFADLPKADQDLLFESAFLELFVLRLA 452
Query: 178 TRYTPEQDTMTFSDGLTLNRTQMHNAGFGPLTDLVFAFANQLLPLEMDDAETGLLSAICL 237
R P + + F +G+ L+R Q GFG D + F++ L + +D + ++A+ +
Sbjct: 453 YRSNPVEGKLIFCNGVVLHRLQCVR-GFGEWIDSIVEFSSNLQNMNIDISAFSCIAALAM 511
Query: 238 ICGDRQDLEQPDRVDMLQEPLLEALKVYVRKRRP--SRPHMFPKMLMKITDLRSISAKGA 295
+ +R L++P RV+ LQ ++ LK +V +RP+ K+L K+ +LR++ +G
Sbjct: 512 VT-ERHGLKEPKRVEELQNKIVNCLKDHVTFNNGGLNRPNYLSKLLGKLPELRTLCTQGL 570
Query: 296 ERVITLKMEIPGSMPPLIQEMLENSEGLDTL 326
+R+ LK+E P +I ++ LDTL
Sbjct: 571 QRIFYLKLEDLVPPPAIIDKLF-----LDTL 596
>gi|27894344 nuclear receptor subfamily 4, group A, member 1 [Homo
sapiens]
Length = 598
Score = 96.3 bits (238), Expect = 4e-20
Identities = 64/185 (34%), Positives = 101/185 (54%), Gaps = 9/185 (4%)
Query: 144 EFAKQLPGFTTLTIADQITLLKAACLDILILRICTRYTPEQDTMTFSDGLTLNRTQMHNA 203
++A+++PGF L+ ADQ LL++A L++ ILR+ R P + + F GL L+R Q
Sbjct: 419 KWAEKIPGFAELSPADQDLLLESAFLELFILRLAYRSKPGEGKLIFCSGLVLHRLQCAR- 477
Query: 204 GFGPLTDLVFAFANQLLPLEMDDAETGLLSAICLICGDRQDLEQPDRVDMLQEPLLEALK 263
GFG D + AF+ L L +D LSA+ LI DR L++P RV+ LQ + LK
Sbjct: 478 GFGDWIDSILAFSRSLHSLLVDVPAFACLSALVLIT-DRHGLQEPRRVEELQNRIASCLK 536
Query: 264 VYVR--KRRPSRPHMFPKMLMKITDLRSISAKGAERVITLKMEIPGSMPPLIQEMLENSE 321
+V P ++L K+ +LR++ +G +R+ LK+E PP+I ++
Sbjct: 537 EHVAAVAGEPQPASCLSRLLGKLPELRTLCTQGLQRIFYLKLEDLVPPPPIIDKIF---- 592
Query: 322 GLDTL 326
+DTL
Sbjct: 593 -MDTL 596
>gi|21361342 nuclear receptor subfamily 4, group A, member 1 [Homo
sapiens]
Length = 598
Score = 96.3 bits (238), Expect = 4e-20
Identities = 64/185 (34%), Positives = 101/185 (54%), Gaps = 9/185 (4%)
Query: 144 EFAKQLPGFTTLTIADQITLLKAACLDILILRICTRYTPEQDTMTFSDGLTLNRTQMHNA 203
++A+++PGF L+ ADQ LL++A L++ ILR+ R P + + F GL L+R Q
Sbjct: 419 KWAEKIPGFAELSPADQDLLLESAFLELFILRLAYRSKPGEGKLIFCSGLVLHRLQCAR- 477
Query: 204 GFGPLTDLVFAFANQLLPLEMDDAETGLLSAICLICGDRQDLEQPDRVDMLQEPLLEALK 263
GFG D + AF+ L L +D LSA+ LI DR L++P RV+ LQ + LK
Sbjct: 478 GFGDWIDSILAFSRSLHSLLVDVPAFACLSALVLIT-DRHGLQEPRRVEELQNRIASCLK 536
Query: 264 VYVR--KRRPSRPHMFPKMLMKITDLRSISAKGAERVITLKMEIPGSMPPLIQEMLENSE 321
+V P ++L K+ +LR++ +G +R+ LK+E PP+I ++
Sbjct: 537 EHVAAVAGEPQPASCLSRLLGKLPELRTLCTQGLQRIFYLKLEDLVPPPPIIDKIF---- 592
Query: 322 GLDTL 326
+DTL
Sbjct: 593 -MDTL 596
>gi|45545429 estrogen-related receptor gamma isoform 2 [Homo
sapiens]
Length = 435
Score = 95.9 bits (237), Expect = 5e-20
Identities = 71/259 (27%), Positives = 121/259 (46%), Gaps = 7/259 (2%)
Query: 61 VRNDRNKKKKEVPKPECSESYTLTPEVGELIEKVRKAHQETFPALCQLGKYTTNNSSEQR 120
VR R K K+ + + S L P+ L++ +K + + L +
Sbjct: 180 VRGGRQKYKRRI---DAENSPYLNPQ---LVQPAKKPYNKIVSHLLVAEPEKIYAMPDPT 233
Query: 121 V-SLDIDLWDKFSELSTKCIIKTVEFAKQLPGFTTLTIADQITLLKAACLDILILRICTR 179
V DI +L+ + ++ + +AK +PGF+TL++ADQ++LL++A ++ILIL + R
Sbjct: 234 VPDSDIKALTTLCDLADRELVVIIGWAKHIPGFSTLSLADQMSLLQSAWMEILILGVVYR 293
Query: 180 YTPEQDTMTFSDGLTLNRTQMHNAGFGPLTDLVFAFANQLLPLEMDDAETGLLSAICLIC 239
+D + ++D ++ Q AG L + + + ++++ E L AI L
Sbjct: 294 SLSFEDELVYADDYIMDEDQSKLAGLLDLNNAILQLVKKYKSMKLEKEEFVTLKAIALAN 353
Query: 240 GDRQDLEQPDRVDMLQEPLLEALKVYVRKRRPSRPHMFPKMLMKITDLRSISAKGAERVI 299
D +E + V LQ+ L EAL+ Y + P KMLM + LR S K +
Sbjct: 354 SDSMHIEDVEAVQKLQDVLHEALQDYEAGQHMEDPRRAGKMLMTLPLLRQTSTKAVQHFY 413
Query: 300 TLKMEIPGSMPPLIQEMLE 318
+K+E M L EMLE
Sbjct: 414 NIKLEGKVPMHKLFLEMLE 432
>gi|45545427 estrogen-related receptor gamma isoform 2 [Homo
sapiens]
Length = 435
Score = 95.9 bits (237), Expect = 5e-20
Identities = 71/259 (27%), Positives = 121/259 (46%), Gaps = 7/259 (2%)
Query: 61 VRNDRNKKKKEVPKPECSESYTLTPEVGELIEKVRKAHQETFPALCQLGKYTTNNSSEQR 120
VR R K K+ + + S L P+ L++ +K + + L +
Sbjct: 180 VRGGRQKYKRRI---DAENSPYLNPQ---LVQPAKKPYNKIVSHLLVAEPEKIYAMPDPT 233
Query: 121 V-SLDIDLWDKFSELSTKCIIKTVEFAKQLPGFTTLTIADQITLLKAACLDILILRICTR 179
V DI +L+ + ++ + +AK +PGF+TL++ADQ++LL++A ++ILIL + R
Sbjct: 234 VPDSDIKALTTLCDLADRELVVIIGWAKHIPGFSTLSLADQMSLLQSAWMEILILGVVYR 293
Query: 180 YTPEQDTMTFSDGLTLNRTQMHNAGFGPLTDLVFAFANQLLPLEMDDAETGLLSAICLIC 239
+D + ++D ++ Q AG L + + + ++++ E L AI L
Sbjct: 294 SLSFEDELVYADDYIMDEDQSKLAGLLDLNNAILQLVKKYKSMKLEKEEFVTLKAIALAN 353
Query: 240 GDRQDLEQPDRVDMLQEPLLEALKVYVRKRRPSRPHMFPKMLMKITDLRSISAKGAERVI 299
D +E + V LQ+ L EAL+ Y + P KMLM + LR S K +
Sbjct: 354 SDSMHIEDVEAVQKLQDVLHEALQDYEAGQHMEDPRRAGKMLMTLPLLRQTSTKAVQHFY 413
Query: 300 TLKMEIPGSMPPLIQEMLE 318
+K+E M L EMLE
Sbjct: 414 NIKLEGKVPMHKLFLEMLE 432
>gi|45545433 estrogen-related receptor gamma isoform 1 [Homo
sapiens]
Length = 458
Score = 95.9 bits (237), Expect = 5e-20
Identities = 71/259 (27%), Positives = 121/259 (46%), Gaps = 7/259 (2%)
Query: 61 VRNDRNKKKKEVPKPECSESYTLTPEVGELIEKVRKAHQETFPALCQLGKYTTNNSSEQR 120
VR R K K+ + + S L P+ L++ +K + + L +
Sbjct: 203 VRGGRQKYKRRI---DAENSPYLNPQ---LVQPAKKPYNKIVSHLLVAEPEKIYAMPDPT 256
Query: 121 V-SLDIDLWDKFSELSTKCIIKTVEFAKQLPGFTTLTIADQITLLKAACLDILILRICTR 179
V DI +L+ + ++ + +AK +PGF+TL++ADQ++LL++A ++ILIL + R
Sbjct: 257 VPDSDIKALTTLCDLADRELVVIIGWAKHIPGFSTLSLADQMSLLQSAWMEILILGVVYR 316
Query: 180 YTPEQDTMTFSDGLTLNRTQMHNAGFGPLTDLVFAFANQLLPLEMDDAETGLLSAICLIC 239
+D + ++D ++ Q AG L + + + ++++ E L AI L
Sbjct: 317 SLSFEDELVYADDYIMDEDQSKLAGLLDLNNAILQLVKKYKSMKLEKEEFVTLKAIALAN 376
Query: 240 GDRQDLEQPDRVDMLQEPLLEALKVYVRKRRPSRPHMFPKMLMKITDLRSISAKGAERVI 299
D +E + V LQ+ L EAL+ Y + P KMLM + LR S K +
Sbjct: 377 SDSMHIEDVEAVQKLQDVLHEALQDYEAGQHMEDPRRAGKMLMTLPLLRQTSTKAVQHFY 436
Query: 300 TLKMEIPGSMPPLIQEMLE 318
+K+E M L EMLE
Sbjct: 437 NIKLEGKVPMHKLFLEMLE 455
>gi|197209821 estrogen-related receptor gamma isoform 2 [Homo
sapiens]
Length = 435
Score = 95.9 bits (237), Expect = 5e-20
Identities = 71/259 (27%), Positives = 121/259 (46%), Gaps = 7/259 (2%)
Query: 61 VRNDRNKKKKEVPKPECSESYTLTPEVGELIEKVRKAHQETFPALCQLGKYTTNNSSEQR 120
VR R K K+ + + S L P+ L++ +K + + L +
Sbjct: 180 VRGGRQKYKRRI---DAENSPYLNPQ---LVQPAKKPYNKIVSHLLVAEPEKIYAMPDPT 233
Query: 121 V-SLDIDLWDKFSELSTKCIIKTVEFAKQLPGFTTLTIADQITLLKAACLDILILRICTR 179
V DI +L+ + ++ + +AK +PGF+TL++ADQ++LL++A ++ILIL + R
Sbjct: 234 VPDSDIKALTTLCDLADRELVVIIGWAKHIPGFSTLSLADQMSLLQSAWMEILILGVVYR 293
Query: 180 YTPEQDTMTFSDGLTLNRTQMHNAGFGPLTDLVFAFANQLLPLEMDDAETGLLSAICLIC 239
+D + ++D ++ Q AG L + + + ++++ E L AI L
Sbjct: 294 SLSFEDELVYADDYIMDEDQSKLAGLLDLNNAILQLVKKYKSMKLEKEEFVTLKAIALAN 353
Query: 240 GDRQDLEQPDRVDMLQEPLLEALKVYVRKRRPSRPHMFPKMLMKITDLRSISAKGAERVI 299
D +E + V LQ+ L EAL+ Y + P KMLM + LR S K +
Sbjct: 354 SDSMHIEDVEAVQKLQDVLHEALQDYEAGQHMEDPRRAGKMLMTLPLLRQTSTKAVQHFY 413
Query: 300 TLKMEIPGSMPPLIQEMLE 318
+K+E M L EMLE
Sbjct: 414 NIKLEGKVPMHKLFLEMLE 432
>gi|238550159 estrogen-related receptor beta [Homo sapiens]
Length = 508
Score = 94.4 bits (233), Expect = 1e-19
Identities = 59/207 (28%), Positives = 104/207 (50%)
Query: 124 DIDLWDKFSELSTKCIIKTVEFAKQLPGFTTLTIADQITLLKAACLDILILRICTRYTPE 183
DI +L+ + ++ + +AK +PGF++L++ DQ++LL++A ++ILIL I R P
Sbjct: 236 DIKALTTLCDLADRELVVIIGWAKHIPGFSSLSLGDQMSLLQSAWMEILILGIVYRSLPY 295
Query: 184 QDTMTFSDGLTLNRTQMHNAGFGPLTDLVFAFANQLLPLEMDDAETGLLSAICLICGDRQ 243
D + +++ ++ AG L + + L+++ E L A+ L D
Sbjct: 296 DDKLVYAEDYIMDEEHSRLAGLLELYRAILQLVRRYKKLKVEKEEFVTLKALALANSDSM 355
Query: 244 DLEQPDRVDMLQEPLLEALKVYVRKRRPSRPHMFPKMLMKITDLRSISAKGAERVITLKM 303
+E + V LQ+ L EAL+ Y +R P K+L+ + LR +AK + ++K+
Sbjct: 356 YIEDLEAVQKLQDLLHEALQDYELSQRHEEPWRTGKLLLTLPLLRQTAAKAVQHFYSVKL 415
Query: 304 EIPGSMPPLIQEMLENSEGLDTLSGQP 330
+ M L EMLE G + L G P
Sbjct: 416 QGKVPMHKLFLEMLEAKVGQEQLRGSP 442
Database: hs.faa
Posted date: Aug 4, 2009 4:42 PM
Number of letters in database: 18,247,518
Number of sequences in database: 37,866
Lambda K H
0.316 0.134 0.401
Gapped
Lambda K H
0.267 0.0410 0.140
Matrix: BLOSUM62
Gap Penalties: Existence: 11, Extension: 1
Number of Hits to DB: 17,284,088
Number of Sequences: 37866
Number of extensions: 956121
Number of successful extensions: 6038
Number of sequences better than 10.0: 30
Number of HSP's better than 10.0 without gapping: 144
Number of HSP's successfully gapped in prelim test: 108
Number of HSP's that attempted gapping in prelim test: 5479
Number of HSP's gapped (non-prelim): 578
length of query: 365
length of database: 18,247,518
effective HSP length: 104
effective length of query: 261
effective length of database: 14,309,454
effective search space: 3734767494
effective search space used: 3734767494
T: 11
A: 40
X1: 16 ( 7.3 bits)
X2: 38 (14.6 bits)
X3: 64 (24.7 bits)
S1: 41 (21.6 bits)
S2: 62 (28.5 bits)
Search results were obtained with NCBI BLAST and RefSeq entries.
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Guide to the Human Genome
Copyright © 2010 by Stewart Scherer. All rights reserved.