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Search of human proteins with 223718064
BLASTP 2.2.11 [Jun-05-2005]
Reference: Altschul, Stephen F., Thomas L. Madden, Alejandro A. Schaffer,
Jinghui Zhang, Zheng Zhang, Webb Miller, and David J. Lipman (1997),
"Gapped BLAST and PSI-BLAST: a new generation of protein database search
programs", Nucleic Acids Res. 25:3389-3402.
Query= gi|223718064 retinoic acid receptor, alpha isoform 1 [Homo
sapiens]
(462 letters)
Database: hs.faa
37,866 sequences; 18,247,518 total letters
Searching..................................................done
Score E
Sequences producing significant alignments: (bits) Value
gi|223718064 retinoic acid receptor, alpha isoform 1 [Homo sapiens] 950 0.0
gi|4506419 retinoic acid receptor, alpha isoform 1 [Homo sapiens] 950 0.0
gi|67459914 retinoic acid receptor, alpha isoform 2 [Homo sapiens] 825 0.0
gi|14916494 retinoic acid receptor, beta isoform 1 [Homo sapiens] 677 0.0
gi|4506423 retinoic acid receptor, gamma isoform 1 [Homo sapiens] 648 0.0
gi|112181200 retinoic acid receptor, gamma isoform 2 [Homo sapiens] 642 0.0
gi|223718070 retinoic acid receptor, alpha isoform 4 [Homo sapiens] 615 e-176
gi|7706625 retinoic acid receptor, beta isoform 2 [Homo sapiens] 560 e-160
gi|40806160 thyroid hormone receptor, alpha isoform 1 [Homo sapi... 249 5e-66
gi|189491771 thyroid hormone receptor, beta [Homo sapiens] 238 7e-63
gi|189491769 thyroid hormone receptor, beta [Homo sapiens] 238 7e-63
gi|40806162 thyroid hormone receptor, beta [Homo sapiens] 238 7e-63
gi|20127452 thyroid hormone receptor, alpha isoform 2 [Homo sapi... 223 2e-58
gi|5902068 retinoid X receptor, gamma isoform a [Homo sapiens] 217 2e-56
gi|194294519 nuclear receptor subfamily 1, group H, member 3 iso... 207 2e-53
gi|194294517 nuclear receptor subfamily 1, group H, member 3 iso... 207 2e-53
gi|4506755 retinoid X receptor, alpha [Homo sapiens] 204 1e-52
gi|85362735 nuclear receptor subfamily 1, group H, member 2 [Hom... 204 1e-52
gi|11415052 retinoid X receptor, beta [Homo sapiens] 200 3e-51
gi|27894361 nuclear receptor subfamily 4, group A, member 3 isof... 197 2e-50
gi|27894357 nuclear receptor subfamily 4, group A, member 3 isof... 197 2e-50
gi|27894355 nuclear receptor subfamily 4, group A, member 3 isof... 197 2e-50
gi|5453822 nuclear receptor subfamily 4, group A, member 2 [Homo... 196 4e-50
gi|27894344 nuclear receptor subfamily 4, group A, member 1 [Hom... 191 1e-48
gi|21361342 nuclear receptor subfamily 4, group A, member 1 [Hom... 191 1e-48
gi|45545429 estrogen-related receptor gamma isoform 2 [Homo sapi... 188 1e-47
gi|45545427 estrogen-related receptor gamma isoform 2 [Homo sapi... 188 1e-47
gi|45545433 estrogen-related receptor gamma isoform 1 [Homo sapi... 188 1e-47
gi|197209821 estrogen-related receptor gamma isoform 2 [Homo sap... 188 1e-47
gi|20070199 nuclear receptor subfamily 2, group F, member 6 [Hom... 176 3e-44
>gi|223718064 retinoic acid receptor, alpha isoform 1 [Homo sapiens]
Length = 462
Score = 950 bits (2456), Expect = 0.0
Identities = 462/462 (100%), Positives = 462/462 (100%)
Query: 1 MASNSSSCPTPGGGHLNGYPVPPYAFFFPPMLGGLSPPGALTTLQHQLPVSGYSTPSPAT 60
MASNSSSCPTPGGGHLNGYPVPPYAFFFPPMLGGLSPPGALTTLQHQLPVSGYSTPSPAT
Sbjct: 1 MASNSSSCPTPGGGHLNGYPVPPYAFFFPPMLGGLSPPGALTTLQHQLPVSGYSTPSPAT 60
Query: 61 IETQSSSSEEIVPSPPSPPPLPRIYKPCFVCQDKSSGYHYGVSACEGCKGFFRRSIQKNM 120
IETQSSSSEEIVPSPPSPPPLPRIYKPCFVCQDKSSGYHYGVSACEGCKGFFRRSIQKNM
Sbjct: 61 IETQSSSSEEIVPSPPSPPPLPRIYKPCFVCQDKSSGYHYGVSACEGCKGFFRRSIQKNM 120
Query: 121 VYTCHRDKNCIINKVTRNRCQYCRLQKCFEVGMSKESVRNDRNKKKKEVPKPECSESYTL 180
VYTCHRDKNCIINKVTRNRCQYCRLQKCFEVGMSKESVRNDRNKKKKEVPKPECSESYTL
Sbjct: 121 VYTCHRDKNCIINKVTRNRCQYCRLQKCFEVGMSKESVRNDRNKKKKEVPKPECSESYTL 180
Query: 181 TPEVGELIEKVRKAHQETFPALCQLGKYTTNNSSEQRVSLDIDLWDKFSELSTKCIIKTV 240
TPEVGELIEKVRKAHQETFPALCQLGKYTTNNSSEQRVSLDIDLWDKFSELSTKCIIKTV
Sbjct: 181 TPEVGELIEKVRKAHQETFPALCQLGKYTTNNSSEQRVSLDIDLWDKFSELSTKCIIKTV 240
Query: 241 EFAKQLPGFTTLTIADQITLLKAACLDILILRICTRYTPEQDTMTFSDGLTLNRTQMHNA 300
EFAKQLPGFTTLTIADQITLLKAACLDILILRICTRYTPEQDTMTFSDGLTLNRTQMHNA
Sbjct: 241 EFAKQLPGFTTLTIADQITLLKAACLDILILRICTRYTPEQDTMTFSDGLTLNRTQMHNA 300
Query: 301 GFGPLTDLVFAFANQLLPLEMDDAETGLLSAICLICGDRQDLEQPDRVDMLQEPLLEALK 360
GFGPLTDLVFAFANQLLPLEMDDAETGLLSAICLICGDRQDLEQPDRVDMLQEPLLEALK
Sbjct: 301 GFGPLTDLVFAFANQLLPLEMDDAETGLLSAICLICGDRQDLEQPDRVDMLQEPLLEALK 360
Query: 361 VYVRKRRPSRPHMFPKMLMKITDLRSISAKGAERVITLKMEIPGSMPPLIQEMLENSEGL 420
VYVRKRRPSRPHMFPKMLMKITDLRSISAKGAERVITLKMEIPGSMPPLIQEMLENSEGL
Sbjct: 361 VYVRKRRPSRPHMFPKMLMKITDLRSISAKGAERVITLKMEIPGSMPPLIQEMLENSEGL 420
Query: 421 DTLSGQPGGGGRDGGGLAPPPGSCSPSLSPSSNRSSPATHSP 462
DTLSGQPGGGGRDGGGLAPPPGSCSPSLSPSSNRSSPATHSP
Sbjct: 421 DTLSGQPGGGGRDGGGLAPPPGSCSPSLSPSSNRSSPATHSP 462
>gi|4506419 retinoic acid receptor, alpha isoform 1 [Homo sapiens]
Length = 462
Score = 950 bits (2456), Expect = 0.0
Identities = 462/462 (100%), Positives = 462/462 (100%)
Query: 1 MASNSSSCPTPGGGHLNGYPVPPYAFFFPPMLGGLSPPGALTTLQHQLPVSGYSTPSPAT 60
MASNSSSCPTPGGGHLNGYPVPPYAFFFPPMLGGLSPPGALTTLQHQLPVSGYSTPSPAT
Sbjct: 1 MASNSSSCPTPGGGHLNGYPVPPYAFFFPPMLGGLSPPGALTTLQHQLPVSGYSTPSPAT 60
Query: 61 IETQSSSSEEIVPSPPSPPPLPRIYKPCFVCQDKSSGYHYGVSACEGCKGFFRRSIQKNM 120
IETQSSSSEEIVPSPPSPPPLPRIYKPCFVCQDKSSGYHYGVSACEGCKGFFRRSIQKNM
Sbjct: 61 IETQSSSSEEIVPSPPSPPPLPRIYKPCFVCQDKSSGYHYGVSACEGCKGFFRRSIQKNM 120
Query: 121 VYTCHRDKNCIINKVTRNRCQYCRLQKCFEVGMSKESVRNDRNKKKKEVPKPECSESYTL 180
VYTCHRDKNCIINKVTRNRCQYCRLQKCFEVGMSKESVRNDRNKKKKEVPKPECSESYTL
Sbjct: 121 VYTCHRDKNCIINKVTRNRCQYCRLQKCFEVGMSKESVRNDRNKKKKEVPKPECSESYTL 180
Query: 181 TPEVGELIEKVRKAHQETFPALCQLGKYTTNNSSEQRVSLDIDLWDKFSELSTKCIIKTV 240
TPEVGELIEKVRKAHQETFPALCQLGKYTTNNSSEQRVSLDIDLWDKFSELSTKCIIKTV
Sbjct: 181 TPEVGELIEKVRKAHQETFPALCQLGKYTTNNSSEQRVSLDIDLWDKFSELSTKCIIKTV 240
Query: 241 EFAKQLPGFTTLTIADQITLLKAACLDILILRICTRYTPEQDTMTFSDGLTLNRTQMHNA 300
EFAKQLPGFTTLTIADQITLLKAACLDILILRICTRYTPEQDTMTFSDGLTLNRTQMHNA
Sbjct: 241 EFAKQLPGFTTLTIADQITLLKAACLDILILRICTRYTPEQDTMTFSDGLTLNRTQMHNA 300
Query: 301 GFGPLTDLVFAFANQLLPLEMDDAETGLLSAICLICGDRQDLEQPDRVDMLQEPLLEALK 360
GFGPLTDLVFAFANQLLPLEMDDAETGLLSAICLICGDRQDLEQPDRVDMLQEPLLEALK
Sbjct: 301 GFGPLTDLVFAFANQLLPLEMDDAETGLLSAICLICGDRQDLEQPDRVDMLQEPLLEALK 360
Query: 361 VYVRKRRPSRPHMFPKMLMKITDLRSISAKGAERVITLKMEIPGSMPPLIQEMLENSEGL 420
VYVRKRRPSRPHMFPKMLMKITDLRSISAKGAERVITLKMEIPGSMPPLIQEMLENSEGL
Sbjct: 361 VYVRKRRPSRPHMFPKMLMKITDLRSISAKGAERVITLKMEIPGSMPPLIQEMLENSEGL 420
Query: 421 DTLSGQPGGGGRDGGGLAPPPGSCSPSLSPSSNRSSPATHSP 462
DTLSGQPGGGGRDGGGLAPPPGSCSPSLSPSSNRSSPATHSP
Sbjct: 421 DTLSGQPGGGGRDGGGLAPPPGSCSPSLSPSSNRSSPATHSP 462
>gi|67459914 retinoic acid receptor, alpha isoform 2 [Homo sapiens]
Length = 457
Score = 825 bits (2132), Expect = 0.0
Identities = 410/424 (96%), Positives = 411/424 (96%), Gaps = 9/424 (2%)
Query: 48 LPVSG-YSTP--------SPATIETQSSSSEEIVPSPPSPPPLPRIYKPCFVCQDKSSGY 98
LP G YSTP S +IETQSSSSEEIVPSPPSPPPLPRIYKPCFVCQDKSSGY
Sbjct: 34 LPAPGPYSTPLRTPLWNGSNHSIETQSSSSEEIVPSPPSPPPLPRIYKPCFVCQDKSSGY 93
Query: 99 HYGVSACEGCKGFFRRSIQKNMVYTCHRDKNCIINKVTRNRCQYCRLQKCFEVGMSKESV 158
HYGVSACEGCKGFFRRSIQKNMVYTCHRDKNCIINKVTRNRCQYCRLQKCFEVGMSKESV
Sbjct: 94 HYGVSACEGCKGFFRRSIQKNMVYTCHRDKNCIINKVTRNRCQYCRLQKCFEVGMSKESV 153
Query: 159 RNDRNKKKKEVPKPECSESYTLTPEVGELIEKVRKAHQETFPALCQLGKYTTNNSSEQRV 218
RNDRNKKKKEVPKPECSESYTLTPEVGELIEKVRKAHQETFPALCQLGKYTTNNSSEQRV
Sbjct: 154 RNDRNKKKKEVPKPECSESYTLTPEVGELIEKVRKAHQETFPALCQLGKYTTNNSSEQRV 213
Query: 219 SLDIDLWDKFSELSTKCIIKTVEFAKQLPGFTTLTIADQITLLKAACLDILILRICTRYT 278
SLDIDLWDKFSELSTKCIIKTVEFAKQLPGFTTLTIADQITLLKAACLDILILRICTRYT
Sbjct: 214 SLDIDLWDKFSELSTKCIIKTVEFAKQLPGFTTLTIADQITLLKAACLDILILRICTRYT 273
Query: 279 PEQDTMTFSDGLTLNRTQMHNAGFGPLTDLVFAFANQLLPLEMDDAETGLLSAICLICGD 338
PEQDTMTFSDGLTLNRTQMHNAGFGPLTDLVFAFANQLLPLEMDDAETGLLSAICLICGD
Sbjct: 274 PEQDTMTFSDGLTLNRTQMHNAGFGPLTDLVFAFANQLLPLEMDDAETGLLSAICLICGD 333
Query: 339 RQDLEQPDRVDMLQEPLLEALKVYVRKRRPSRPHMFPKMLMKITDLRSISAKGAERVITL 398
RQDLEQPDRVDMLQEPLLEALKVYVRKRRPSRPHMFPKMLMKITDLRSISAKGAERVITL
Sbjct: 334 RQDLEQPDRVDMLQEPLLEALKVYVRKRRPSRPHMFPKMLMKITDLRSISAKGAERVITL 393
Query: 399 KMEIPGSMPPLIQEMLENSEGLDTLSGQPGGGGRDGGGLAPPPGSCSPSLSPSSNRSSPA 458
KMEIPGSMPPLIQEMLENSEGLDTLSGQPGGGGRDGGGLAPPPGSCSPSLSPSSNRSSPA
Sbjct: 394 KMEIPGSMPPLIQEMLENSEGLDTLSGQPGGGGRDGGGLAPPPGSCSPSLSPSSNRSSPA 453
Query: 459 THSP 462
THSP
Sbjct: 454 THSP 457
>gi|14916494 retinoic acid receptor, beta isoform 1 [Homo sapiens]
Length = 448
Score = 677 bits (1748), Expect = 0.0
Identities = 330/403 (81%), Positives = 360/403 (89%), Gaps = 10/403 (2%)
Query: 60 TIETQSSSSEEIVPSPPSPPPLPRIYKPCFVCQDKSSGYHYGVSACEGCKGFFRRSIQKN 119
+IETQS+SSEE+VPSPPSP P PR+YKPCFVCQDKSSGYHYGVSACEGCKGFFRRSIQKN
Sbjct: 53 SIETQSTSSEELVPSPPSPLPPPRVYKPCFVCQDKSSGYHYGVSACEGCKGFFRRSIQKN 112
Query: 120 MVYTCHRDKNCIINKVTRNRCQYCRLQKCFEVGMSKESVRNDRNKKKKEVPKPECSESYT 179
M+YTCHRDKNC+INKVTRNRCQYCRLQKCFEVGMSKESVRNDRNKKKKE K EC+ESY
Sbjct: 113 MIYTCHRDKNCVINKVTRNRCQYCRLQKCFEVGMSKESVRNDRNKKKKETSKQECTESYE 172
Query: 180 LTPEVGELIEKVRKAHQETFPALCQLGKYTTNNSSEQRVSLDIDLWDKFSELSTKCIIKT 239
+T E+ +L EK+RKAHQETFP+LCQLGKYTTN+S++ RV LD+ LWDKFSEL+TKCIIK
Sbjct: 173 MTAELDDLTEKIRKAHQETFPSLCQLGKYTTNSSADHRVRLDLGLWDKFSELATKCIIKI 232
Query: 240 VEFAKQLPGFTTLTIADQITLLKAACLDILILRICTRYTPEQDTMTFSDGLTLNRTQMHN 299
VEFAK+LPGFT LTIADQITLLKAACLDILILRICTRYTPEQDTMTFSDGLTLNRTQMHN
Sbjct: 233 VEFAKRLPGFTGLTIADQITLLKAACLDILILRICTRYTPEQDTMTFSDGLTLNRTQMHN 292
Query: 300 AGFGPLTDLVFAFANQLLPLEMDDAETGLLSAICLICGDRQDLEQPDRVDMLQEPLLEAL 359
AGFGPLTDLVF FANQLLPLEMDD ETGLLSAICLICGDRQDLE+P +VD LQEPLLEAL
Sbjct: 293 AGFGPLTDLVFTFANQLLPLEMDDTETGLLSAICLICGDRQDLEEPTKVDKLQEPLLEAL 352
Query: 360 KVYVRKRRPSRPHMFPKMLMKITDLRSISAKGAERVITLKMEIPGSMPPLIQEMLENSEG 419
K+Y+RKRRPS+PHMFPK+LMKITDLRSISAKGAERVITLKMEIPGSMPPLIQEMLENSEG
Sbjct: 353 KIYIRKRRPSKPHMFPKILMKITDLRSISAKGAERVITLKMEIPGSMPPLIQEMLENSEG 412
Query: 420 LDTLSGQPGGGGRDGGGLAPPPGSCSPSLSPSSNRSSPATHSP 462
+ L+ G + SPS+SPSS +S + SP
Sbjct: 413 HEPLTPSSSGNTAEH----------SPSISPSSVENSGVSQSP 445
>gi|4506423 retinoic acid receptor, gamma isoform 1 [Homo sapiens]
Length = 454
Score = 648 bits (1671), Expect = 0.0
Identities = 330/457 (72%), Positives = 366/457 (80%), Gaps = 21/457 (4%)
Query: 1 MASNSSSCPTPGG-GHLNGYPVPPYAFFFPPMLGGLSP-----PGALTTLQHQLPVSGYS 54
MA+N G G +GYP + F FP L G P P Q LP S
Sbjct: 1 MATNKERLFAAGALGPGSGYPGAGFPFAFPGALRGSPPFEMLSPSFRGLGQPDLPKEMAS 60
Query: 55 TPSPATIETQSSSSEEIVPSPPSPPPLPRIYKPCFVCQDKSSGYHYGVSACEGCKGFFRR 114
++ETQS+SSEE+VPS PSPPP PR+YKPCFVC DKSSGYHYGVS+CEGCKGFFRR
Sbjct: 61 L----SVETQSTSSEEMVPSSPSPPPPPRVYKPCFVCNDKSSGYHYGVSSCEGCKGFFRR 116
Query: 115 SIQKNMVYTCHRDKNCIINKVTRNRCQYCRLQKCFEVGMSKESVRNDRNKKKKEVPKPEC 174
SIQKNMVYTCHRDKNCIINKVTRNRCQYCRLQKCFEVGMSKE+VRNDRNKKKKEV +
Sbjct: 117 SIQKNMVYTCHRDKNCIINKVTRNRCQYCRLQKCFEVGMSKEAVRNDRNKKKKEVKEEGS 176
Query: 175 SESYTLTPEVGELIEKVRKAHQETFPALCQLGKYTTNNSSEQRVSLDIDLWDKFSELSTK 234
+SY L+P++ ELI KV KAHQETFP+LCQLGKYTTN+S++ RV LD+ LWDKFSEL+TK
Sbjct: 177 PDSYELSPQLEELITKVSKAHQETFPSLCQLGKYTTNSSADHRVQLDLGLWDKFSELATK 236
Query: 235 CIIKTVEFAKQLPGFTTLTIADQITLLKAACLDILILRICTRYTPEQDTMTFSDGLTLNR 294
CIIK VEFAK+LPGFT L+IADQITLLKAACLDIL+LRICTRYTPEQDTMTFSDGLTLNR
Sbjct: 237 CIIKIVEFAKRLPGFTGLSIADQITLLKAACLDILMLRICTRYTPEQDTMTFSDGLTLNR 296
Query: 295 TQMHNAGFGPLTDLVFAFANQLLPLEMDDAETGLLSAICLICGDRQDLEQPDRVDMLQEP 354
TQMHNAGFGPLTDLVFAFA QLLPLEMDD ETGLLSAICLICGDR DLE+P++VD LQEP
Sbjct: 297 TQMHNAGFGPLTDLVFAFAGQLLPLEMDDTETGLLSAICLICGDRMDLEEPEKVDKLQEP 356
Query: 355 LLEALKVYVRKRRPSRPHMFPKMLMKITDLRSISAKGAERVITLKMEIPGSMPPLIQEML 414
LLEAL++Y R+RRPS+P+MFP+MLMKITDLR IS KGAER ITLKMEIPG MPPLI+EML
Sbjct: 357 LLEALRLYARRRRPSQPYMFPRMLMKITDLRGISTKGAERAITLKMEIPGPMPPLIREML 416
Query: 415 ENSEGLDTLSGQPG-----------GGGRDGGGLAPP 440
EN E + S QPG GG+ GGL P
Sbjct: 417 ENPEMFEDDSSQPGPHPNASSEDEVPGGQGKGGLKSP 453
>gi|112181200 retinoic acid receptor, gamma isoform 2 [Homo sapiens]
Length = 443
Score = 642 bits (1657), Expect = 0.0
Identities = 314/405 (77%), Positives = 350/405 (86%), Gaps = 14/405 (3%)
Query: 50 VSGYSTPSPAT---IETQSSSSEEIVPSPPSPPPLPRIYKPCFVCQDKSSGYHYGVSACE 106
+ ++ P PA+ +ETQS+SSEE+VPS PSPPP PR+YKPCFVC DKSSGYHYGVS+CE
Sbjct: 38 LESFAWPQPASLQSVETQSTSSEEMVPSSPSPPPPPRVYKPCFVCNDKSSGYHYGVSSCE 97
Query: 107 GCKGFFRRSIQKNMVYTCHRDKNCIINKVTRNRCQYCRLQKCFEVGMSKESVRNDRNKKK 166
GCKGFFRRSIQKNMVYTCHRDKNCIINKVTRNRCQYCRLQKCFEVGMSKE+VRNDRNKKK
Sbjct: 98 GCKGFFRRSIQKNMVYTCHRDKNCIINKVTRNRCQYCRLQKCFEVGMSKEAVRNDRNKKK 157
Query: 167 KEVPKPECSESYTLTPEVGELIEKVRKAHQETFPALCQLGKYTTNNSSEQRVSLDIDLWD 226
KEV + +SY L+P++ ELI KV KAHQETFP+LCQLGKYTTN+S++ RV LD+ LWD
Sbjct: 158 KEVKEEGSPDSYELSPQLEELITKVSKAHQETFPSLCQLGKYTTNSSADHRVQLDLGLWD 217
Query: 227 KFSELSTKCIIKTVEFAKQLPGFTTLTIADQITLLKAACLDILILRICTRYTPEQDTMTF 286
KFSEL+TKCIIK VEFAK+LPGFT L+IADQITLLKAACLDIL+LRICTRYTPEQDTMTF
Sbjct: 218 KFSELATKCIIKIVEFAKRLPGFTGLSIADQITLLKAACLDILMLRICTRYTPEQDTMTF 277
Query: 287 SDGLTLNRTQMHNAGFGPLTDLVFAFANQLLPLEMDDAETGLLSAICLICGDRQDLEQPD 346
SDGLTLNRTQMHNAGFGPLTDLVFAFA QLLPLEMDD ETGLLSAICLICGDR DLE+P+
Sbjct: 278 SDGLTLNRTQMHNAGFGPLTDLVFAFAGQLLPLEMDDTETGLLSAICLICGDRMDLEEPE 337
Query: 347 RVDMLQEPLLEALKVYVRKRRPSRPHMFPKMLMKITDLRSISAKGAERVITLKMEIPGSM 406
+VD LQEPLLEAL++Y R+RRPS+P+MFP+MLMKITDLR IS KGAER ITLKMEIPG M
Sbjct: 338 KVDKLQEPLLEALRLYARRRRPSQPYMFPRMLMKITDLRGISTKGAERAITLKMEIPGPM 397
Query: 407 PPLIQEMLENSEGLDTLSGQPG-----------GGGRDGGGLAPP 440
PPLI+EMLEN E + S QPG GG+ GGL P
Sbjct: 398 PPLIREMLENPEMFEDDSSQPGPHPNASSEDEVPGGQGKGGLKSP 442
>gi|223718070 retinoic acid receptor, alpha isoform 4 [Homo sapiens]
Length = 365
Score = 615 bits (1585), Expect = e-176
Identities = 306/309 (99%), Positives = 307/309 (99%)
Query: 154 SKESVRNDRNKKKKEVPKPECSESYTLTPEVGELIEKVRKAHQETFPALCQLGKYTTNNS 213
S +VRNDRNKKKKEVPKPECSESYTLTPEVGELIEKVRKAHQETFPALCQLGKYTTNNS
Sbjct: 57 SPATVRNDRNKKKKEVPKPECSESYTLTPEVGELIEKVRKAHQETFPALCQLGKYTTNNS 116
Query: 214 SEQRVSLDIDLWDKFSELSTKCIIKTVEFAKQLPGFTTLTIADQITLLKAACLDILILRI 273
SEQRVSLDIDLWDKFSELSTKCIIKTVEFAKQLPGFTTLTIADQITLLKAACLDILILRI
Sbjct: 117 SEQRVSLDIDLWDKFSELSTKCIIKTVEFAKQLPGFTTLTIADQITLLKAACLDILILRI 176
Query: 274 CTRYTPEQDTMTFSDGLTLNRTQMHNAGFGPLTDLVFAFANQLLPLEMDDAETGLLSAIC 333
CTRYTPEQDTMTFSDGLTLNRTQMHNAGFGPLTDLVFAFANQLLPLEMDDAETGLLSAIC
Sbjct: 177 CTRYTPEQDTMTFSDGLTLNRTQMHNAGFGPLTDLVFAFANQLLPLEMDDAETGLLSAIC 236
Query: 334 LICGDRQDLEQPDRVDMLQEPLLEALKVYVRKRRPSRPHMFPKMLMKITDLRSISAKGAE 393
LICGDRQDLEQPDRVDMLQEPLLEALKVYVRKRRPSRPHMFPKMLMKITDLRSISAKGAE
Sbjct: 237 LICGDRQDLEQPDRVDMLQEPLLEALKVYVRKRRPSRPHMFPKMLMKITDLRSISAKGAE 296
Query: 394 RVITLKMEIPGSMPPLIQEMLENSEGLDTLSGQPGGGGRDGGGLAPPPGSCSPSLSPSSN 453
RVITLKMEIPGSMPPLIQEMLENSEGLDTLSGQPGGGGRDGGGLAPPPGSCSPSLSPSSN
Sbjct: 297 RVITLKMEIPGSMPPLIQEMLENSEGLDTLSGQPGGGGRDGGGLAPPPGSCSPSLSPSSN 356
Query: 454 RSSPATHSP 462
RSSPATHSP
Sbjct: 357 RSSPATHSP 365
Score = 140 bits (353), Expect = 2e-33
Identities = 63/75 (84%), Positives = 67/75 (89%)
Query: 1 MASNSSSCPTPGGGHLNGYPVPPYAFFFPPMLGGLSPPGALTTLQHQLPVSGYSTPSPAT 60
MASNSSSCPTPGGGHLNGYPVPPYAFFFPPMLGGLSPPGALTTLQHQLPVSGYSTPSPAT
Sbjct: 1 MASNSSSCPTPGGGHLNGYPVPPYAFFFPPMLGGLSPPGALTTLQHQLPVSGYSTPSPAT 60
Query: 61 IETQSSSSEEIVPSP 75
+ + ++ VP P
Sbjct: 61 VRNDRNKKKKEVPKP 75
>gi|7706625 retinoic acid receptor, beta isoform 2 [Homo sapiens]
Length = 336
Score = 560 bits (1444), Expect = e-160
Identities = 276/343 (80%), Positives = 302/343 (88%), Gaps = 10/343 (2%)
Query: 120 MVYTCHRDKNCIINKVTRNRCQYCRLQKCFEVGMSKESVRNDRNKKKKEVPKPECSESYT 179
M+YTCHRDKNC+INKVTRNRCQYCRLQKCFEVGMSKESVRNDRNKKKKE K EC+ESY
Sbjct: 1 MIYTCHRDKNCVINKVTRNRCQYCRLQKCFEVGMSKESVRNDRNKKKKETSKQECTESYE 60
Query: 180 LTPEVGELIEKVRKAHQETFPALCQLGKYTTNNSSEQRVSLDIDLWDKFSELSTKCIIKT 239
+T E+ +L EK+RKAHQETFP+LCQLGKYTTN+S++ RV LD+ LWDKFSEL+TKCIIK
Sbjct: 61 MTAELDDLTEKIRKAHQETFPSLCQLGKYTTNSSADHRVRLDLGLWDKFSELATKCIIKI 120
Query: 240 VEFAKQLPGFTTLTIADQITLLKAACLDILILRICTRYTPEQDTMTFSDGLTLNRTQMHN 299
VEFAK+LPGFT LTIADQITLLKAACLDILILRICTRYTPEQDTMTFSDGLTLNRTQMHN
Sbjct: 121 VEFAKRLPGFTGLTIADQITLLKAACLDILILRICTRYTPEQDTMTFSDGLTLNRTQMHN 180
Query: 300 AGFGPLTDLVFAFANQLLPLEMDDAETGLLSAICLICGDRQDLEQPDRVDMLQEPLLEAL 359
AGFGPLTDLVF FANQLLPLEMDD ETGLLSAICLICGDRQDLE+P +VD LQEPLLEAL
Sbjct: 181 AGFGPLTDLVFTFANQLLPLEMDDTETGLLSAICLICGDRQDLEEPTKVDKLQEPLLEAL 240
Query: 360 KVYVRKRRPSRPHMFPKMLMKITDLRSISAKGAERVITLKMEIPGSMPPLIQEMLENSEG 419
K+Y+RKRRPS+PHMFPK+LMKITDLRSISAKGAERVITLKMEIPGSMPPLIQEMLENSEG
Sbjct: 241 KIYIRKRRPSKPHMFPKILMKITDLRSISAKGAERVITLKMEIPGSMPPLIQEMLENSEG 300
Query: 420 LDTLSGQPGGGGRDGGGLAPPPGSCSPSLSPSSNRSSPATHSP 462
+ L+ G + SPS+SPSS +S + SP
Sbjct: 301 HEPLTPSSSGNTAEH----------SPSISPSSVENSGVSQSP 333
>gi|40806160 thyroid hormone receptor, alpha isoform 1 [Homo
sapiens]
Length = 410
Score = 249 bits (635), Expect = 5e-66
Identities = 136/357 (38%), Positives = 201/357 (56%), Gaps = 26/357 (7%)
Query: 88 CFVCQDKSSGYHYGVSACEGCKGFFRRSIQKNM--VYTCHRDKNCIINKVTRNRCQYCRL 145
C VC DK++GYHY CEGCKGFFRR+IQKN+ Y+C D C+I+K+TRN+CQ CR
Sbjct: 53 CVVCGDKATGYHYRCITCEGCKGFFRRTIQKNLHPTYSCKYDSCCVIDKITRNQCQLCRF 112
Query: 146 QKCFEVGMSKESVRND-------------RNKKKKEVPKPECSESYTLTPEVGELIEKVR 192
+KC VGM+ + V +D R +++KE + TPE +LI
Sbjct: 113 KKCIAVGMAMDLVLDDSKRVAKRKLIEQNRERRRKEEMIRSLQQRPEPTPEEWDLIHIAT 172
Query: 193 KAHQETFPALC---QLGKYTTNNSSEQRV-------SLDIDLWDKFSELSTKCIIKTVEF 242
+AH+ T Q K+ ++ + + +D++ + +F+++ T I + V+F
Sbjct: 173 EAHRSTNAQGSHWKQRRKFLPDDIGQSPIVSMPDGDKVDLEAFSEFTKIITPAITRVVDF 232
Query: 243 AKQLPGFTTLTIADQITLLKAACLDILILRICTRYTPEQDTMTFSDGLTLNRTQMHNAGF 302
AK+LP F+ L DQI LLK C++I+ LR RY PE DT+T S + + R Q+ N G
Sbjct: 233 AKKLPMFSELPCEDQIILLKGCCMEIMSLRAAVRYDPESDTLTLSGEMAVKREQLKNGGL 292
Query: 303 GPLTDLVFAFANQLLPLEMDDAETGLLSAICLICGDRQDLEQPDRVDMLQEPLLEALKVY 362
G ++D +F L +DD E LL A+ L+ DR L D+++ QE L A + Y
Sbjct: 293 GVVSDAIFELGKSLSAFNLDDTEVALLQAVLLMSTDRSGLLCVDKIEKSQEAYLLAFEHY 352
Query: 363 VRKRRPSRPHMFPKMLMKITDLRSISAKGAERVITLKMEIPGSM-PPLIQEMLENSE 418
V R+ + PH +PK+LMK+TDLR I A A R + +K+E P + PPL E+ E+ E
Sbjct: 353 VNHRKHNIPHFWPKLLMKVTDLRMIGACHASRFLHMKVECPTELFPPLFLEVFEDQE 409
>gi|189491771 thyroid hormone receptor, beta [Homo sapiens]
Length = 461
Score = 238 bits (608), Expect = 7e-63
Identities = 139/393 (35%), Positives = 208/393 (52%), Gaps = 32/393 (8%)
Query: 50 VSGYSTPSPATIETQSSSSEEIVPSPPSPPPLPRIYKPCFVCQDKSSGYHYGVSACEGCK 109
V+ S S T +T+ + +PS L C VC DK++GYHY CEGCK
Sbjct: 75 VNDQSVSSAQTFQTEEKKCKGYIPSYLDKDEL------CVVCGDKATGYHYRCITCEGCK 128
Query: 110 GFFRRSIQKNM--VYTCHRDKNCIINKVTRNRCQYCRLQKCFEVGMSKESVRND------ 161
GFFRR+IQKN+ Y+C + C+I+KVTRN+CQ CR +KC VGM+ + V +D
Sbjct: 129 GFFRRTIQKNLHPSYSCKYEGKCVIDKVTRNQCQECRFKKCIYVGMATDLVLDDSKRLAK 188
Query: 162 -------RNKKKKEVPKPECSESYTLTPEVGELIEKVRKAHQETFPALC---QLGKYTTN 211
R K+++E + T E ELI+ V +AH T Q K+
Sbjct: 189 RKLIEENREKRRREELQKSIGHKPEPTDEEWELIKTVTEAHVATNAQGSHWKQKRKFLPE 248
Query: 212 NSSEQRV-------SLDIDLWDKFSELSTKCIIKTVEFAKQLPGFTTLTIADQITLLKAA 264
+ + + +D++ + F+++ T I + V+FAK+LP F L DQI LLK
Sbjct: 249 DIGQAPIVNAPEGGKVDLEAFSHFTKIITPAITRVVDFAKKLPMFCELPCEDQIILLKGC 308
Query: 265 CLDILILRICTRYTPEQDTMTFSDGLTLNRTQMHNAGFGPLTDLVFAFANQLLPLEMDDA 324
C++I+ LR RY PE +T+T + + + R Q+ N G G ++D +F L +DD
Sbjct: 309 CMEIMSLRAAVRYDPESETLTLNGEMAVTRGQLKNGGLGVVSDAIFDLGMSLSSFNLDDT 368
Query: 325 ETGLLSAICLICGDRQDLEQPDRVDMLQEPLLEALKVYVRKRRPSRPHMFPKMLMKITDL 384
E LL A+ L+ DR L +R++ Q+ L A + Y+ R+ H +PK+LMK+TDL
Sbjct: 369 EVALLQAVLLMSSDRPGLACVERIEKYQDSFLLAFEHYINYRKHHVTHFWPKLLMKVTDL 428
Query: 385 RSISAKGAERVITLKMEIPGSM-PPLIQEMLEN 416
R I A A R + +K+E P + PPL E+ E+
Sbjct: 429 RMIGACHASRFLHMKVECPTELFPPLFLEVFED 461
>gi|189491769 thyroid hormone receptor, beta [Homo sapiens]
Length = 461
Score = 238 bits (608), Expect = 7e-63
Identities = 139/393 (35%), Positives = 208/393 (52%), Gaps = 32/393 (8%)
Query: 50 VSGYSTPSPATIETQSSSSEEIVPSPPSPPPLPRIYKPCFVCQDKSSGYHYGVSACEGCK 109
V+ S S T +T+ + +PS L C VC DK++GYHY CEGCK
Sbjct: 75 VNDQSVSSAQTFQTEEKKCKGYIPSYLDKDEL------CVVCGDKATGYHYRCITCEGCK 128
Query: 110 GFFRRSIQKNM--VYTCHRDKNCIINKVTRNRCQYCRLQKCFEVGMSKESVRND------ 161
GFFRR+IQKN+ Y+C + C+I+KVTRN+CQ CR +KC VGM+ + V +D
Sbjct: 129 GFFRRTIQKNLHPSYSCKYEGKCVIDKVTRNQCQECRFKKCIYVGMATDLVLDDSKRLAK 188
Query: 162 -------RNKKKKEVPKPECSESYTLTPEVGELIEKVRKAHQETFPALC---QLGKYTTN 211
R K+++E + T E ELI+ V +AH T Q K+
Sbjct: 189 RKLIEENREKRRREELQKSIGHKPEPTDEEWELIKTVTEAHVATNAQGSHWKQKRKFLPE 248
Query: 212 NSSEQRV-------SLDIDLWDKFSELSTKCIIKTVEFAKQLPGFTTLTIADQITLLKAA 264
+ + + +D++ + F+++ T I + V+FAK+LP F L DQI LLK
Sbjct: 249 DIGQAPIVNAPEGGKVDLEAFSHFTKIITPAITRVVDFAKKLPMFCELPCEDQIILLKGC 308
Query: 265 CLDILILRICTRYTPEQDTMTFSDGLTLNRTQMHNAGFGPLTDLVFAFANQLLPLEMDDA 324
C++I+ LR RY PE +T+T + + + R Q+ N G G ++D +F L +DD
Sbjct: 309 CMEIMSLRAAVRYDPESETLTLNGEMAVTRGQLKNGGLGVVSDAIFDLGMSLSSFNLDDT 368
Query: 325 ETGLLSAICLICGDRQDLEQPDRVDMLQEPLLEALKVYVRKRRPSRPHMFPKMLMKITDL 384
E LL A+ L+ DR L +R++ Q+ L A + Y+ R+ H +PK+LMK+TDL
Sbjct: 369 EVALLQAVLLMSSDRPGLACVERIEKYQDSFLLAFEHYINYRKHHVTHFWPKLLMKVTDL 428
Query: 385 RSISAKGAERVITLKMEIPGSM-PPLIQEMLEN 416
R I A A R + +K+E P + PPL E+ E+
Sbjct: 429 RMIGACHASRFLHMKVECPTELFPPLFLEVFED 461
>gi|40806162 thyroid hormone receptor, beta [Homo sapiens]
Length = 461
Score = 238 bits (608), Expect = 7e-63
Identities = 139/393 (35%), Positives = 208/393 (52%), Gaps = 32/393 (8%)
Query: 50 VSGYSTPSPATIETQSSSSEEIVPSPPSPPPLPRIYKPCFVCQDKSSGYHYGVSACEGCK 109
V+ S S T +T+ + +PS L C VC DK++GYHY CEGCK
Sbjct: 75 VNDQSVSSAQTFQTEEKKCKGYIPSYLDKDEL------CVVCGDKATGYHYRCITCEGCK 128
Query: 110 GFFRRSIQKNM--VYTCHRDKNCIINKVTRNRCQYCRLQKCFEVGMSKESVRND------ 161
GFFRR+IQKN+ Y+C + C+I+KVTRN+CQ CR +KC VGM+ + V +D
Sbjct: 129 GFFRRTIQKNLHPSYSCKYEGKCVIDKVTRNQCQECRFKKCIYVGMATDLVLDDSKRLAK 188
Query: 162 -------RNKKKKEVPKPECSESYTLTPEVGELIEKVRKAHQETFPALC---QLGKYTTN 211
R K+++E + T E ELI+ V +AH T Q K+
Sbjct: 189 RKLIEENREKRRREELQKSIGHKPEPTDEEWELIKTVTEAHVATNAQGSHWKQKRKFLPE 248
Query: 212 NSSEQRV-------SLDIDLWDKFSELSTKCIIKTVEFAKQLPGFTTLTIADQITLLKAA 264
+ + + +D++ + F+++ T I + V+FAK+LP F L DQI LLK
Sbjct: 249 DIGQAPIVNAPEGGKVDLEAFSHFTKIITPAITRVVDFAKKLPMFCELPCEDQIILLKGC 308
Query: 265 CLDILILRICTRYTPEQDTMTFSDGLTLNRTQMHNAGFGPLTDLVFAFANQLLPLEMDDA 324
C++I+ LR RY PE +T+T + + + R Q+ N G G ++D +F L +DD
Sbjct: 309 CMEIMSLRAAVRYDPESETLTLNGEMAVTRGQLKNGGLGVVSDAIFDLGMSLSSFNLDDT 368
Query: 325 ETGLLSAICLICGDRQDLEQPDRVDMLQEPLLEALKVYVRKRRPSRPHMFPKMLMKITDL 384
E LL A+ L+ DR L +R++ Q+ L A + Y+ R+ H +PK+LMK+TDL
Sbjct: 369 EVALLQAVLLMSSDRPGLACVERIEKYQDSFLLAFEHYINYRKHHVTHFWPKLLMKVTDL 428
Query: 385 RSISAKGAERVITLKMEIPGSM-PPLIQEMLEN 416
R I A A R + +K+E P + PPL E+ E+
Sbjct: 429 RMIGACHASRFLHMKVECPTELFPPLFLEVFED 461
>gi|20127452 thyroid hormone receptor, alpha isoform 2 [Homo
sapiens]
Length = 490
Score = 223 bits (569), Expect = 2e-58
Identities = 124/331 (37%), Positives = 185/331 (55%), Gaps = 26/331 (7%)
Query: 88 CFVCQDKSSGYHYGVSACEGCKGFFRRSIQKNM--VYTCHRDKNCIINKVTRNRCQYCRL 145
C VC DK++GYHY CEGCKGFFRR+IQKN+ Y+C D C+I+K+TRN+CQ CR
Sbjct: 53 CVVCGDKATGYHYRCITCEGCKGFFRRTIQKNLHPTYSCKYDSCCVIDKITRNQCQLCRF 112
Query: 146 QKCFEVGMSKESVRND-------------RNKKKKEVPKPECSESYTLTPEVGELIEKVR 192
+KC VGM+ + V +D R +++KE + TPE +LI
Sbjct: 113 KKCIAVGMAMDLVLDDSKRVAKRKLIEQNRERRRKEEMIRSLQQRPEPTPEEWDLIHIAT 172
Query: 193 KAHQETFPALC---QLGKYTTNNSSEQRV-------SLDIDLWDKFSELSTKCIIKTVEF 242
+AH+ T Q K+ ++ + + +D++ + +F+++ T I + V+F
Sbjct: 173 EAHRSTNAQGSHWKQRRKFLPDDIGQSPIVSMPDGDKVDLEAFSEFTKIITPAITRVVDF 232
Query: 243 AKQLPGFTTLTIADQITLLKAACLDILILRICTRYTPEQDTMTFSDGLTLNRTQMHNAGF 302
AK+LP F+ L DQI LLK C++I+ LR RY PE DT+T S + + R Q+ N G
Sbjct: 233 AKKLPMFSELPCEDQIILLKGCCMEIMSLRAAVRYDPESDTLTLSGEMAVKREQLKNGGL 292
Query: 303 GPLTDLVFAFANQLLPLEMDDAETGLLSAICLICGDRQDLEQPDRVDMLQEPLLEALKVY 362
G ++D +F L +DD E LL A+ L+ DR L D+++ QE L A + Y
Sbjct: 293 GVVSDAIFELGKSLSAFNLDDTEVALLQAVLLMSTDRSGLLCVDKIEKSQEAYLLAFEHY 352
Query: 363 VRKRRPSRPHMFPKMLMKITDLR-SISAKGA 392
V R+ + PH +PK+LMK +++ SI KGA
Sbjct: 353 VNHRKHNIPHFWPKLLMKEREVQSSILYKGA 383
>gi|5902068 retinoid X receptor, gamma isoform a [Homo sapiens]
Length = 463
Score = 217 bits (553), Expect = 2e-56
Identities = 125/371 (33%), Positives = 198/371 (53%), Gaps = 23/371 (6%)
Query: 57 SPATIETQSSSSEEIVPSP----------PSPPPLPRIYKPCFVCQDKSSGYHYGVSACE 106
S + SSSE+I P P PS P + C +C D+SSG HYGV +CE
Sbjct: 98 SQLNVVNSVSSSEDIKPLPGLPGIGNMNYPSTSPGSLVKHICAICGDRSSGKHYGVYSCE 157
Query: 107 GCKGFFRRSIQKNMVYTCHRDKNCIINKVTRNRCQYCRLQKCFEVGMSKESVRNDRNKKK 166
GCKGFF+R+I+K+++YTC +K+C+I+K RNRCQYCR QKC +GM +E+V+ +R + +
Sbjct: 158 GCKGFFKRTIRKDLIYTCRDNKDCLIDKRQRNRCQYCRYQKCLVMGMKREAVQEERQRSR 217
Query: 167 KEV-PKPECSESYTLTPEVGELIEKVRKAHQETFPALCQLGKYTTNNSSEQRVSLDIDLW 225
+ + EC+ S +E++ +A P G NS+ V+
Sbjct: 218 ERAESEAECATS----GHEDMPVERILEAELAVEPKTESYGDMNMENSTNDPVT------ 267
Query: 226 DKFSELSTKCIIKTVEFAKQLPGFTTLTIADQITLLKAACLDILILRICTRYTPEQDTMT 285
+ K + VE+AK++P F+ LT+ DQ+ LL+A ++LI R QD +
Sbjct: 268 -NICHAADKQLFTLVEWAKRIPHFSDLTLEDQVILLRAGWNELLIASFSHRSVSVQDGIL 326
Query: 286 FSDGLTLNRTQMHNAGFGPLTDLVFA-FANQLLPLEMDDAETGLLSAICLICGDRQDLEQ 344
+ GL ++R+ H+AG G + D V +++ ++MD +E G L AI L D + L
Sbjct: 327 LATGLHVHRSSAHSAGVGSIFDRVLTELVSKMKDMQMDKSELGCLRAIVLFNPDAKGLSN 386
Query: 345 PDRVDMLQEPLLEALKVYVRKRRPSRPHMFPKMLMKITDLRSISAKGAERVITLKMEIPG 404
P V+ L+E + L+ Y +++ P +P F K+L+++ LRSI K E + K+
Sbjct: 387 PSEVETLREKVYATLEAYTKQKYPEQPGRFAKLLLRLPALRSIGLKCLEHLFFFKLIGDT 446
Query: 405 SMPPLIQEMLE 415
+ + EMLE
Sbjct: 447 PIDTFLMEMLE 457
>gi|194294519 nuclear receptor subfamily 1, group H, member 3
isoform c [Homo sapiens]
Length = 402
Score = 207 bits (526), Expect = 2e-53
Identities = 127/393 (32%), Positives = 207/393 (52%), Gaps = 28/393 (7%)
Query: 52 GYSTPSPATIETQS---SSSEEIVPSPPSPPPLPRIY--KPCFVCQDKSSGYHYGVSACE 106
G P + T++ S EI P P P++ + C VC DK+SG+HY V +CE
Sbjct: 12 GLEAAEPTALLTRAEPPSEPTEIRPQKRKKGPAPKMLGNELCSVCGDKASGFHYNVLSCE 71
Query: 107 GCKGFFRRSIQKNMVYTCHRDKNCIINKVTRNRCQYCRLQKCFEVGMSKESVRNDRNKKK 166
GCKGFFRRS+ K Y CH +C ++ R +CQ CRL+KC + GM +E V ++ +
Sbjct: 72 GCKGFFRRSVIKGAHYICHSGGHCPMDTYMRRKCQECRLRKCRQAGMREECVLSEEQIRL 131
Query: 167 KEVPKPECSESYT----------------LTPEVGELIEKVRKAHQE----TFPALCQLG 206
K++ + E +++ L+PE +IEK+ A Q+ +F ++
Sbjct: 132 KKLKRQEEEQAHATSLPPRASSPPQILPQLSPEQLGMIEKLVAAQQQCNRRSFSDRLRVT 191
Query: 207 KYTTNNSSEQRVSLDIDLWDKFSELSTKCIIKTVEFAKQLPGFTTLTIADQITLLKAACL 266
+ R + + F+EL+ + + V+FAKQLPGF L+ DQI LLK + +
Sbjct: 192 PWPMAPDPHSREARQ-QRFAHFTELAIVSVQEIVDFAKQLPGFLQLSREDQIALLKTSAI 250
Query: 267 DILILRICTRYTPEQDTMTFSDGLTLNRTQMHNAGFG-PLTDLVFAFANQLLPLEMDDAE 325
++++L RY P +++TF + NR AG + +F F+ + L+++DAE
Sbjct: 251 EVMLLETSRRYNPGSESITFLKDFSYNREDFAKAGLQVEFINPIFEFSRAMNELQLNDAE 310
Query: 326 TGLLSAICLICGDRQDLEQPDRVDMLQEPLLEALKVYVRKRRPSRPHMFPKMLMKITDLR 385
LL AI + DR +++ +V+ LQ +EAL YV P MFP+MLMK+ LR
Sbjct: 311 FALLIAISIFSADRPNVQDQLQVERLQHTYVEALHAYVSIHHPHDRLMFPRMLMKLVSLR 370
Query: 386 SISAKGAERVITLKMEIPGSMPPLIQEMLENSE 418
++S+ +E+V L+++ +PPL+ E+ + E
Sbjct: 371 TLSSVHSEQVFALRLQ-DKKLPPLLSEIWDVHE 402
>gi|194294517 nuclear receptor subfamily 1, group H, member 3
isoform a [Homo sapiens]
Length = 447
Score = 207 bits (526), Expect = 2e-53
Identities = 127/393 (32%), Positives = 207/393 (52%), Gaps = 28/393 (7%)
Query: 52 GYSTPSPATIETQS---SSSEEIVPSPPSPPPLPRIY--KPCFVCQDKSSGYHYGVSACE 106
G P + T++ S EI P P P++ + C VC DK+SG+HY V +CE
Sbjct: 57 GLEAAEPTALLTRAEPPSEPTEIRPQKRKKGPAPKMLGNELCSVCGDKASGFHYNVLSCE 116
Query: 107 GCKGFFRRSIQKNMVYTCHRDKNCIINKVTRNRCQYCRLQKCFEVGMSKESVRNDRNKKK 166
GCKGFFRRS+ K Y CH +C ++ R +CQ CRL+KC + GM +E V ++ +
Sbjct: 117 GCKGFFRRSVIKGAHYICHSGGHCPMDTYMRRKCQECRLRKCRQAGMREECVLSEEQIRL 176
Query: 167 KEVPKPECSESYT----------------LTPEVGELIEKVRKAHQE----TFPALCQLG 206
K++ + E +++ L+PE +IEK+ A Q+ +F ++
Sbjct: 177 KKLKRQEEEQAHATSLPPRASSPPQILPQLSPEQLGMIEKLVAAQQQCNRRSFSDRLRVT 236
Query: 207 KYTTNNSSEQRVSLDIDLWDKFSELSTKCIIKTVEFAKQLPGFTTLTIADQITLLKAACL 266
+ R + + F+EL+ + + V+FAKQLPGF L+ DQI LLK + +
Sbjct: 237 PWPMAPDPHSREARQ-QRFAHFTELAIVSVQEIVDFAKQLPGFLQLSREDQIALLKTSAI 295
Query: 267 DILILRICTRYTPEQDTMTFSDGLTLNRTQMHNAGFG-PLTDLVFAFANQLLPLEMDDAE 325
++++L RY P +++TF + NR AG + +F F+ + L+++DAE
Sbjct: 296 EVMLLETSRRYNPGSESITFLKDFSYNREDFAKAGLQVEFINPIFEFSRAMNELQLNDAE 355
Query: 326 TGLLSAICLICGDRQDLEQPDRVDMLQEPLLEALKVYVRKRRPSRPHMFPKMLMKITDLR 385
LL AI + DR +++ +V+ LQ +EAL YV P MFP+MLMK+ LR
Sbjct: 356 FALLIAISIFSADRPNVQDQLQVERLQHTYVEALHAYVSIHHPHDRLMFPRMLMKLVSLR 415
Query: 386 SISAKGAERVITLKMEIPGSMPPLIQEMLENSE 418
++S+ +E+V L+++ +PPL+ E+ + E
Sbjct: 416 TLSSVHSEQVFALRLQ-DKKLPPLLSEIWDVHE 447
>gi|4506755 retinoid X receptor, alpha [Homo sapiens]
Length = 462
Score = 204 bits (520), Expect = 1e-52
Identities = 131/401 (32%), Positives = 204/401 (50%), Gaps = 21/401 (5%)
Query: 29 PPMLGGLSPPGALTTLQHQLPVSGYSTPSPATIETQS--SSSEEI-----------VPSP 75
PP SP G + P G+ST SP + SSSE+I VP+
Sbjct: 63 PPFSVISSPMGPHSMSVPTTPTLGFSTGSPQLSSPMNPVSSSEDIKPPLGLNGVLKVPAH 122
Query: 76 PSPPPLPRIYKPCFVCQDKSSGYHYGVSACEGCKGFFRRSIQKNMVYTCHRDKNCIINKV 135
PS C +C D+SSG HYGV +CEGCKGFF+R+++K++ YTC +K+C+I+K
Sbjct: 123 PSGNMASFTKHICAICGDRSSGKHYGVYSCEGCKGFFKRTVRKDLTYTCRDNKDCLIDKR 182
Query: 136 TRNRCQYCRLQKCFEVGMSKESVRNDRNKKKKEVPKPECSESYTLTPEVGELIEKVRKAH 195
RNRCQYCR QKC +GM +E+V+ +R + K + E T + +E++ +A
Sbjct: 183 QRNRCQYCRYQKCLAMGMKREAVQEERQRGK---DRNENEVESTSSANEDMPVERILEAE 239
Query: 196 QETFPALCQLGKYTTNNSSEQRVSLDIDLWDKFSELSTKCIIKTVEFAKQLPGFTTLTIA 255
P + Y N S + D + + K + VE+AK++P F+ L +
Sbjct: 240 LAVEP---KTETYVEANMGLNPSSPN-DPVTNICQAADKQLFTLVEWAKRIPHFSELPLD 295
Query: 256 DQITLLKAACLDILILRICTRYTPEQDTMTFSDGLTLNRTQMHNAGFGPLTDLVFA-FAN 314
DQ+ LL+A ++LI R +D + + GL ++R H+AG G + D V +
Sbjct: 296 DQVILLRAGWNELLIASFSHRSIAVKDGILLATGLHVHRNSAHSAGVGAIFDRVLTELVS 355
Query: 315 QLLPLEMDDAETGLLSAICLICGDRQDLEQPDRVDMLQEPLLEALKVYVRKRRPSRPHMF 374
++ ++MD E G L AI L D + L P V+ L+E + +L+ Y + + P +P F
Sbjct: 356 KMRDMQMDKTELGCLRAIVLFNPDSKGLSNPAEVEALREKVYASLEAYCKHKYPEQPGRF 415
Query: 375 PKMLMKITDLRSISAKGAERVITLKMEIPGSMPPLIQEMLE 415
K+L+++ LRSI K E + K+ + + EMLE
Sbjct: 416 AKLLLRLPALRSIGLKCLEHLFFFKLIGDTPIDTFLMEMLE 456
>gi|85362735 nuclear receptor subfamily 1, group H, member 2 [Homo
sapiens]
Length = 461
Score = 204 bits (519), Expect = 1e-52
Identities = 145/474 (30%), Positives = 226/474 (47%), Gaps = 76/474 (16%)
Query: 3 SNSSSCPTPGGGHLNGYPVPPYAFFFPPMLGGLSPPGALTTLQHQLPVSGYSTPSPATIE 62
++S P PG G PP G P + T++ + P P P
Sbjct: 6 TSSLDTPLPGNG--------------PPQPGA---PSSSPTVKEEGPEPWPGGPDPDVPG 48
Query: 63 TQSSSS----EEIVPSPPSPP-------PLPRI--YKPCFVCQDKSSGYHYGVSACEGCK 109
T +SS + ++P P P P P++ ++ C VC DK+SG+HY V +CEGCK
Sbjct: 49 TDEASSACSTDWVIPDPEEEPERKRKKGPAPKMLGHELCRVCGDKASGFHYNVLSCEGCK 108
Query: 110 GFFRRSIQKNMV--YTCHRDKNCIINKVTRNRCQYCRLQKCFEVGMSKESVRNDRNKKKK 167
GFFRRS+ + Y C C ++ R +CQ CRL+KC E GM ++ V ++ +KK
Sbjct: 109 GFFRRSVVRGGARRYACRGGGTCQMDAFMRRKCQQCRLRKCKEAGMREQCVLSEEQIRKK 168
Query: 168 EVPK---------------PECSESYTLTP-------EVG----------ELIEKVRKAH 195
++ K P+ S S P E G +L
Sbjct: 169 KIRKQQQQESQSQSQSPVGPQGSSSSASGPGASPGGSEAGSQGSGEGEGVQLTAAQELMI 228
Query: 196 QETFPALCQLGKYTTNNSSE----------QRVSLDIDLWDKFSELSTKCIIKTVEFAKQ 245
Q+ A Q K + ++ + Q + F+EL+ + + V+FAKQ
Sbjct: 229 QQLVAAQLQCNKRSFSDQPKVTPWPLGADPQSRDARQQRFAHFTELAIISVQEIVDFAKQ 288
Query: 246 LPGFTTLTIADQITLLKAACLDILILRICTRYTPEQDTMTFSDGLTLNRTQMHNAGFG-P 304
+PGF L DQI LLKA+ ++I++L RY E + +TF T ++ H AG
Sbjct: 289 VPGFLQLGREDQIALLKASTIEIMLLETARRYNHETECITFLKDFTYSKDDFHRAGLQVE 348
Query: 305 LTDLVFAFANQLLPLEMDDAETGLLSAICLICGDRQDLEQPDRVDMLQEPLLEALKVYVR 364
+ +F F+ + L +DDAE LL AI + DR ++++P RV+ LQ+P +EAL Y R
Sbjct: 349 FINPIFEFSRAMRRLGLDDAEYALLIAINIFSADRPNVQEPGRVEALQQPYVEALLSYTR 408
Query: 365 KRRPSRPHMFPKMLMKITDLRSISAKGAERVITLKMEIPGSMPPLIQEMLENSE 418
+RP FP+MLMK+ LR++S+ +E+V L+++ +PPL+ E+ + E
Sbjct: 409 IKRPQDQLRFPRMLMKLVSLRTLSSVHSEQVFALRLQ-DKKLPPLLSEIWDVHE 461
>gi|11415052 retinoid X receptor, beta [Homo sapiens]
Length = 533
Score = 200 bits (508), Expect = 3e-51
Identities = 128/409 (31%), Positives = 201/409 (49%), Gaps = 19/409 (4%)
Query: 20 PVPPYAFFFPPMLGGLSPPGALTTLQHQL--PVSGYSTPSPATIETQSSSSEEIVPSP-- 75
P PP FP + + PG PVS S ++ S E V P
Sbjct: 125 PPPPLGSPFPVISSSMGSPGLPPPAPPGFSGPVSSPQINSTVSLPGGGSGPPEDVKPPVL 184
Query: 76 -------PSPPPLPRIYKP-CFVCQDKSSGYHYGVSACEGCKGFFRRSIQKNMVYTCHRD 127
P PP P K C +C D+SSG HYGV +CEGCKGFF+R+I+K++ Y+C +
Sbjct: 185 GVRGLHCPPPPGGPGAGKRLCAICGDRSSGKHYGVYSCEGCKGFFKRTIRKDLTYSCRDN 244
Query: 128 KNCIINKVTRNRCQYCRLQKCFEVGMSKESVRNDRNKKKKEVPKPECSESYTLTPEVGEL 187
K+C ++K RNRCQYCR QKC GM +E+V+ +R + K + E + V +
Sbjct: 245 KDCTVDKRQRNRCQYCRYQKCLATGMKREAVQEERQRGKDKDGDGEGAGGAPEEMPVDRI 304
Query: 188 IEKVRKAHQETFPALCQLGKYTTNNSSEQRVSLDIDLWDKFSELSTKCIIKTVEFAKQLP 247
+E Q++ + G + SS D + + K + VE+AK++P
Sbjct: 305 LEAELAVEQKSDQGVEGPGGTGGSGSSPN------DPVTNICQAADKQLFTLVEWAKRIP 358
Query: 248 GFTTLTIADQITLLKAACLDILILRICTRYTPEQDTMTFSDGLTLNRTQMHNAGFGPLTD 307
F++L + DQ+ LL+A ++LI R +D + + GL ++R H+AG G + D
Sbjct: 359 HFSSLPLDDQVILLRAGWNELLIASFSHRSIDVRDGILLATGLHVHRNSAHSAGVGAIFD 418
Query: 308 LVFA-FANQLLPLEMDDAETGLLSAICLICGDRQDLEQPDRVDMLQEPLLEALKVYVRKR 366
V +++ + MD E G L AI L D + L P V++L+E + +L+ Y +++
Sbjct: 419 RVLTELVSKMRDMRMDKTELGCLRAIILFNPDAKGLSNPSEVEVLREKVYASLETYCKQK 478
Query: 367 RPSRPHMFPKMLMKITDLRSISAKGAERVITLKMEIPGSMPPLIQEMLE 415
P + F K+L+++ LRSI K E + K+ + + EMLE
Sbjct: 479 YPEQQGRFAKLLLRLPALRSIGLKCLEHLFFFKLIGDTPIDTFLMEMLE 527
>gi|27894361 nuclear receptor subfamily 4, group A, member 3 isoform
b [Homo sapiens]
Length = 637
Score = 197 bits (501), Expect = 2e-50
Identities = 146/435 (33%), Positives = 214/435 (49%), Gaps = 33/435 (7%)
Query: 9 PTPGGGHLNGY-PVPPYAFFFPPMLGGLSPPG----ALTTLQHQLPVSGYSTP---SPAT 60
P+P GGH GY P A P LG + G AL + + LP++ + P P
Sbjct: 214 PSPAGGHHLGYDPTAAAALSLP--LGAAAAAGSQAAALESHPYGLPLAKRAAPLAFPPLG 271
Query: 61 IETQSSSSEEIVPSPPSPPPLPRIYKP----CFVCQDKSSGYHYGVSACEGCKGFFRRSI 116
+ ++S + SP P P R C VC D ++ HYGV CEGCKGFF+R++
Sbjct: 272 LTPSPTASSLLGESPSLPSPPSRSSSSGEGTCAVCGDNAACQHYGVRTCEGCKGFFKRTV 331
Query: 117 QKNMVYTCHRDKNCIINKVTRNRCQYCRLQKCFEVGMSKESVRNDRNK--------KKKE 168
QKN Y C +KNC ++K RNRCQYCR QKC VGM KE VR D K K K
Sbjct: 332 QKNAKYVCLANKNCPVDKRRRNRCQYCRFQKCLSVGMVKEVVRTDSLKGRRGRLPSKPKS 391
Query: 169 VPKPECSESYTLTPEVGELIEKVRKAHQETFPALCQLGKYTTNNSSEQRVSLDIDLWDKF 228
+ E S+ +P + + VR A ++ P +Y + + D + +F
Sbjct: 392 PLQQEPSQPSPPSPPICMMNALVR-ALTDSTPRDLDYSRYCP--TDQAAAGTDAEHVQQF 448
Query: 229 SELSTKCIIKTVEFAKQLPGFTTLTIADQITLLKAACLDILILRICTRYTPEQDTMTFSD 288
L T I + +A+++PGFT L DQ L+++A L++ +LR+ R +D F +
Sbjct: 449 YNLLTASIDVSRSWAEKIPGFTDLPKEDQTLLIESAFLELFVLRLSIRSNTAEDKFVFCN 508
Query: 289 GLTLNRTQMHNAGFGPLTDLVFAFANQLLPLEMDDAETGLLSAICLICGDRQDLEQPDRV 348
GL L+R Q GFG D + F+ L L +D LSA+ +I +R L++P RV
Sbjct: 509 GLVLHRLQCLR-GFGEWLDSIKDFSLNLQSLNLDIQALACLSALSMIT-ERHGLKEPKRV 566
Query: 349 DMLQEPLLEALKVYVRKRRPSRPHMFPKMLMKITDLRSISAKGAERVITLKMEIPGSMPP 408
+ L + +LK + K + P K+L + +LR I G +R+ LK+E S P
Sbjct: 567 EELCNKITSSLKDHQSKGQALEP-TESKVLGALVELRKICTLGLQRIFYLKLEDLVSPPS 625
Query: 409 LIQEMLENSEGLDTL 423
+I ++ LDTL
Sbjct: 626 IIDKLF-----LDTL 635
>gi|27894357 nuclear receptor subfamily 4, group A, member 3 isoform
a [Homo sapiens]
Length = 626
Score = 197 bits (501), Expect = 2e-50
Identities = 146/435 (33%), Positives = 214/435 (49%), Gaps = 33/435 (7%)
Query: 9 PTPGGGHLNGY-PVPPYAFFFPPMLGGLSPPG----ALTTLQHQLPVSGYSTP---SPAT 60
P+P GGH GY P A P LG + G AL + + LP++ + P P
Sbjct: 203 PSPAGGHHLGYDPTAAAALSLP--LGAAAAAGSQAAALESHPYGLPLAKRAAPLAFPPLG 260
Query: 61 IETQSSSSEEIVPSPPSPPPLPRIYKP----CFVCQDKSSGYHYGVSACEGCKGFFRRSI 116
+ ++S + SP P P R C VC D ++ HYGV CEGCKGFF+R++
Sbjct: 261 LTPSPTASSLLGESPSLPSPPSRSSSSGEGTCAVCGDNAACQHYGVRTCEGCKGFFKRTV 320
Query: 117 QKNMVYTCHRDKNCIINKVTRNRCQYCRLQKCFEVGMSKESVRNDRNK--------KKKE 168
QKN Y C +KNC ++K RNRCQYCR QKC VGM KE VR D K K K
Sbjct: 321 QKNAKYVCLANKNCPVDKRRRNRCQYCRFQKCLSVGMVKEVVRTDSLKGRRGRLPSKPKS 380
Query: 169 VPKPECSESYTLTPEVGELIEKVRKAHQETFPALCQLGKYTTNNSSEQRVSLDIDLWDKF 228
+ E S+ +P + + VR A ++ P +Y + + D + +F
Sbjct: 381 PLQQEPSQPSPPSPPICMMNALVR-ALTDSTPRDLDYSRYCP--TDQAAAGTDAEHVQQF 437
Query: 229 SELSTKCIIKTVEFAKQLPGFTTLTIADQITLLKAACLDILILRICTRYTPEQDTMTFSD 288
L T I + +A+++PGFT L DQ L+++A L++ +LR+ R +D F +
Sbjct: 438 YNLLTASIDVSRSWAEKIPGFTDLPKEDQTLLIESAFLELFVLRLSIRSNTAEDKFVFCN 497
Query: 289 GLTLNRTQMHNAGFGPLTDLVFAFANQLLPLEMDDAETGLLSAICLICGDRQDLEQPDRV 348
GL L+R Q GFG D + F+ L L +D LSA+ +I +R L++P RV
Sbjct: 498 GLVLHRLQCLR-GFGEWLDSIKDFSLNLQSLNLDIQALACLSALSMIT-ERHGLKEPKRV 555
Query: 349 DMLQEPLLEALKVYVRKRRPSRPHMFPKMLMKITDLRSISAKGAERVITLKMEIPGSMPP 408
+ L + +LK + K + P K+L + +LR I G +R+ LK+E S P
Sbjct: 556 EELCNKITSSLKDHQSKGQALEP-TESKVLGALVELRKICTLGLQRIFYLKLEDLVSPPS 614
Query: 409 LIQEMLENSEGLDTL 423
+I ++ LDTL
Sbjct: 615 IIDKLF-----LDTL 624
>gi|27894355 nuclear receptor subfamily 4, group A, member 3 isoform
a [Homo sapiens]
Length = 626
Score = 197 bits (501), Expect = 2e-50
Identities = 146/435 (33%), Positives = 214/435 (49%), Gaps = 33/435 (7%)
Query: 9 PTPGGGHLNGY-PVPPYAFFFPPMLGGLSPPG----ALTTLQHQLPVSGYSTP---SPAT 60
P+P GGH GY P A P LG + G AL + + LP++ + P P
Sbjct: 203 PSPAGGHHLGYDPTAAAALSLP--LGAAAAAGSQAAALESHPYGLPLAKRAAPLAFPPLG 260
Query: 61 IETQSSSSEEIVPSPPSPPPLPRIYKP----CFVCQDKSSGYHYGVSACEGCKGFFRRSI 116
+ ++S + SP P P R C VC D ++ HYGV CEGCKGFF+R++
Sbjct: 261 LTPSPTASSLLGESPSLPSPPSRSSSSGEGTCAVCGDNAACQHYGVRTCEGCKGFFKRTV 320
Query: 117 QKNMVYTCHRDKNCIINKVTRNRCQYCRLQKCFEVGMSKESVRNDRNK--------KKKE 168
QKN Y C +KNC ++K RNRCQYCR QKC VGM KE VR D K K K
Sbjct: 321 QKNAKYVCLANKNCPVDKRRRNRCQYCRFQKCLSVGMVKEVVRTDSLKGRRGRLPSKPKS 380
Query: 169 VPKPECSESYTLTPEVGELIEKVRKAHQETFPALCQLGKYTTNNSSEQRVSLDIDLWDKF 228
+ E S+ +P + + VR A ++ P +Y + + D + +F
Sbjct: 381 PLQQEPSQPSPPSPPICMMNALVR-ALTDSTPRDLDYSRYCP--TDQAAAGTDAEHVQQF 437
Query: 229 SELSTKCIIKTVEFAKQLPGFTTLTIADQITLLKAACLDILILRICTRYTPEQDTMTFSD 288
L T I + +A+++PGFT L DQ L+++A L++ +LR+ R +D F +
Sbjct: 438 YNLLTASIDVSRSWAEKIPGFTDLPKEDQTLLIESAFLELFVLRLSIRSNTAEDKFVFCN 497
Query: 289 GLTLNRTQMHNAGFGPLTDLVFAFANQLLPLEMDDAETGLLSAICLICGDRQDLEQPDRV 348
GL L+R Q GFG D + F+ L L +D LSA+ +I +R L++P RV
Sbjct: 498 GLVLHRLQCLR-GFGEWLDSIKDFSLNLQSLNLDIQALACLSALSMIT-ERHGLKEPKRV 555
Query: 349 DMLQEPLLEALKVYVRKRRPSRPHMFPKMLMKITDLRSISAKGAERVITLKMEIPGSMPP 408
+ L + +LK + K + P K+L + +LR I G +R+ LK+E S P
Sbjct: 556 EELCNKITSSLKDHQSKGQALEP-TESKVLGALVELRKICTLGLQRIFYLKLEDLVSPPS 614
Query: 409 LIQEMLENSEGLDTL 423
+I ++ LDTL
Sbjct: 615 IIDKLF-----LDTL 624
>gi|5453822 nuclear receptor subfamily 4, group A, member 2 [Homo
sapiens]
Length = 598
Score = 196 bits (498), Expect = 4e-50
Identities = 123/357 (34%), Positives = 193/357 (54%), Gaps = 13/357 (3%)
Query: 72 VPSPPSPPPLPRIYKPCFVCQDKSSGYHYGVSACEGCKGFFRRSIQKNMVYTCHRDKNCI 131
VPSPPS P C VC D ++ HYGV CEGCKGFF+R++QKN Y C +KNC
Sbjct: 248 VPSPPSRGS-PSNEGLCAVCGDNAACQHYGVRTCEGCKGFFKRTVQKNAKYVCLANKNCP 306
Query: 132 INKVTRNRCQYCRLQKCFEVGMSKESVRND--RNKKKKEVPKPECSESYTLTPEVGELIE 189
++K RNRCQYCR QKC VGM KE VR D + ++ + KP+ + + LI
Sbjct: 307 VDKRRRNRCQYCRFQKCLAVGMVKEVVRTDSLKGRRGRLPSKPKSPQEPSPPSPPVSLIS 366
Query: 190 KVRKAHQETFPALCQLG-KYTTNNSSEQRVSLDIDLWDKFSELSTKCIIKTVEFAKQLPG 248
+ +AH ++ PA+ L N Q D +F +L T + +A+++PG
Sbjct: 367 ALVRAHVDSNPAMTSLDYSRFQANPDYQMSGDDTQHIQQFYDLLTGSMEIIRGWAEKIPG 426
Query: 249 FTTLTIADQITLLKAACLDILILRICTRYTPEQDTMTFSDGLTLNRTQMHNAGFGPLTDL 308
F L ADQ L ++A L++ +LR+ R P + + F +G+ L+R Q GFG D
Sbjct: 427 FADLPKADQDLLFESAFLELFVLRLAYRSNPVEGKLIFCNGVVLHRLQCVR-GFGEWIDS 485
Query: 309 VFAFANQLLPLEMDDAETGLLSAICLICGDRQDLEQPDRVDMLQEPLLEALKVYVRKRRP 368
+ F++ L + +D + ++A+ ++ +R L++P RV+ LQ ++ LK +V
Sbjct: 486 IVEFSSNLQNMNIDISAFSCIAALAMVT-ERHGLKEPKRVEELQNKIVNCLKDHVTFNNG 544
Query: 369 --SRPHMFPKMLMKITDLRSISAKGAERVITLKMEIPGSMPPLIQEMLENSEGLDTL 423
+RP+ K+L K+ +LR++ +G +R+ LK+E P +I ++ LDTL
Sbjct: 545 GLNRPNYLSKLLGKLPELRTLCTQGLQRIFYLKLEDLVPPPAIIDKLF-----LDTL 596
>gi|27894344 nuclear receptor subfamily 4, group A, member 1 [Homo
sapiens]
Length = 598
Score = 191 bits (485), Expect = 1e-48
Identities = 144/431 (33%), Positives = 213/431 (49%), Gaps = 39/431 (9%)
Query: 17 NGYPVPPYAFFFPPMLGGLSPPGALTTLQ-------HQLPVS-GYSTPS--PATIETQSS 66
+G P PP F F P G SP A + L+ HQL YS P+ P T
Sbjct: 181 SGPPQPPAFFSFSPPTGP-SPSLAQSPLKLFPSQATHQLGEGESYSMPTAFPGLAPTSPH 239
Query: 67 SSEEIVPSPPSPPPLPRIYKP------CFVCQDKSSGYHYGVSACEGCKGFFRRSIQKNM 120
+ P R P C VC D +S HYGV CEGCKGFF+R++QKN
Sbjct: 240 LEGSGILDTPVTSTKARSGAPGGSEGRCAVCGDNASCQHYGVRTCEGCKGFFKRTVQKNA 299
Query: 121 VYTCHRDKNCIINKVTRNRCQYCRLQKCFEVGMSKESVRNDRNKKKKEVPKPECSESYTL 180
Y C +K+C ++K RNRCQ+CR QKC VGM KE VR D K ++ + +
Sbjct: 300 KYICLANKDCPVDKRRRNRCQFCRFQKCLAVGMVKEVVRTDSLKGRRGRLPSKPKQPPDA 359
Query: 181 TPEVGELIEKVRKAHQETFPALCQLGKYTTNNSSEQRVSL------DIDLWDKFSELSTK 234
+P L+ + +AH ++ P+ +L + S Q + L D +F +L +
Sbjct: 360 SP--ANLLTSLVRAHLDSGPSTAKL-----DYSKFQELVLPHFGKEDAGDVQQFYDLLSG 412
Query: 235 CIIKTVEFAKQLPGFTTLTIADQITLLKAACLDILILRICTRYTPEQDTMTFSDGLTLNR 294
+ ++A+++PGF L+ ADQ LL++A L++ ILR+ R P + + F GL L+R
Sbjct: 413 SLEVIRKWAEKIPGFAELSPADQDLLLESAFLELFILRLAYRSKPGEGKLIFCSGLVLHR 472
Query: 295 TQMHNAGFGPLTDLVFAFANQLLPLEMDDAETGLLSAICLICGDRQDLEQPDRVDMLQEP 354
Q GFG D + AF+ L L +D LSA+ LI DR L++P RV+ LQ
Sbjct: 473 LQCAR-GFGDWIDSILAFSRSLHSLLVDVPAFACLSALVLIT-DRHGLQEPRRVEELQNR 530
Query: 355 LLEALKVYVR--KRRPSRPHMFPKMLMKITDLRSISAKGAERVITLKMEIPGSMPPLIQE 412
+ LK +V P ++L K+ +LR++ +G +R+ LK+E PP+I +
Sbjct: 531 IASCLKEHVAAVAGEPQPASCLSRLLGKLPELRTLCTQGLQRIFYLKLEDLVPPPPIIDK 590
Query: 413 MLENSEGLDTL 423
+ +DTL
Sbjct: 591 IF-----MDTL 596
>gi|21361342 nuclear receptor subfamily 4, group A, member 1 [Homo
sapiens]
Length = 598
Score = 191 bits (485), Expect = 1e-48
Identities = 144/431 (33%), Positives = 213/431 (49%), Gaps = 39/431 (9%)
Query: 17 NGYPVPPYAFFFPPMLGGLSPPGALTTLQ-------HQLPVS-GYSTPS--PATIETQSS 66
+G P PP F F P G SP A + L+ HQL YS P+ P T
Sbjct: 181 SGPPQPPAFFSFSPPTGP-SPSLAQSPLKLFPSQATHQLGEGESYSMPTAFPGLAPTSPH 239
Query: 67 SSEEIVPSPPSPPPLPRIYKP------CFVCQDKSSGYHYGVSACEGCKGFFRRSIQKNM 120
+ P R P C VC D +S HYGV CEGCKGFF+R++QKN
Sbjct: 240 LEGSGILDTPVTSTKARSGAPGGSEGRCAVCGDNASCQHYGVRTCEGCKGFFKRTVQKNA 299
Query: 121 VYTCHRDKNCIINKVTRNRCQYCRLQKCFEVGMSKESVRNDRNKKKKEVPKPECSESYTL 180
Y C +K+C ++K RNRCQ+CR QKC VGM KE VR D K ++ + +
Sbjct: 300 KYICLANKDCPVDKRRRNRCQFCRFQKCLAVGMVKEVVRTDSLKGRRGRLPSKPKQPPDA 359
Query: 181 TPEVGELIEKVRKAHQETFPALCQLGKYTTNNSSEQRVSL------DIDLWDKFSELSTK 234
+P L+ + +AH ++ P+ +L + S Q + L D +F +L +
Sbjct: 360 SP--ANLLTSLVRAHLDSGPSTAKL-----DYSKFQELVLPHFGKEDAGDVQQFYDLLSG 412
Query: 235 CIIKTVEFAKQLPGFTTLTIADQITLLKAACLDILILRICTRYTPEQDTMTFSDGLTLNR 294
+ ++A+++PGF L+ ADQ LL++A L++ ILR+ R P + + F GL L+R
Sbjct: 413 SLEVIRKWAEKIPGFAELSPADQDLLLESAFLELFILRLAYRSKPGEGKLIFCSGLVLHR 472
Query: 295 TQMHNAGFGPLTDLVFAFANQLLPLEMDDAETGLLSAICLICGDRQDLEQPDRVDMLQEP 354
Q GFG D + AF+ L L +D LSA+ LI DR L++P RV+ LQ
Sbjct: 473 LQCAR-GFGDWIDSILAFSRSLHSLLVDVPAFACLSALVLIT-DRHGLQEPRRVEELQNR 530
Query: 355 LLEALKVYVR--KRRPSRPHMFPKMLMKITDLRSISAKGAERVITLKMEIPGSMPPLIQE 412
+ LK +V P ++L K+ +LR++ +G +R+ LK+E PP+I +
Sbjct: 531 IASCLKEHVAAVAGEPQPASCLSRLLGKLPELRTLCTQGLQRIFYLKLEDLVPPPPIIDK 590
Query: 413 MLENSEGLDTL 423
+ +DTL
Sbjct: 591 IF-----MDTL 596
>gi|45545429 estrogen-related receptor gamma isoform 2 [Homo
sapiens]
Length = 435
Score = 188 bits (477), Expect = 1e-47
Identities = 129/414 (31%), Positives = 197/414 (47%), Gaps = 26/414 (6%)
Query: 5 SSSCPTPGGGHLNGYPVPPYAFFFPPMLGGLSPPGALTTLQHQLPVSGYSTPSPATIETQ 64
S S + GH NG PP + P+LGG P L Y S +E
Sbjct: 42 SGSYSSTMNGHQNGLDSPPL-YPSAPILGGSGPVRKL-----------YDDCSSTIVEDP 89
Query: 65 SSSSEEIVPSPPSPPPLPRIYKPCFVCQDKSSGYHYGVSACEGCKGFFRRSIQKNMVYTC 124
+ E ++ S P + C VC D +SGYHYGV++CE CK FF+R+IQ N+ Y+C
Sbjct: 90 QTKCEYMLNSMPK--------RLCLVCGDIASGYHYGVASCEACKAFFKRTIQGNIEYSC 141
Query: 125 HRDKNCIINKVTRNRCQYCRLQKCFEVGMSKESVRNDRNK--KKKEVPKPECSESYTLTP 182
C I K R CQ CR KC +VGM KE VR DR + ++K + + S L P
Sbjct: 142 PATNECEITKRRRKSCQACRFMKCLKVGMLKEGVRLDRVRGGRQKYKRRIDAENSPYLNP 201
Query: 183 EVGELIEKVRKAHQETFPALCQLGKYTTNNSSEQRV-SLDIDLWDKFSELSTKCIIKTVE 241
+L++ +K + + L + V DI +L+ + ++ +
Sbjct: 202 ---QLVQPAKKPYNKIVSHLLVAEPEKIYAMPDPTVPDSDIKALTTLCDLADRELVVIIG 258
Query: 242 FAKQLPGFTTLTIADQITLLKAACLDILILRICTRYTPEQDTMTFSDGLTLNRTQMHNAG 301
+AK +PGF+TL++ADQ++LL++A ++ILIL + R +D + ++D ++ Q AG
Sbjct: 259 WAKHIPGFSTLSLADQMSLLQSAWMEILILGVVYRSLSFEDELVYADDYIMDEDQSKLAG 318
Query: 302 FGPLTDLVFAFANQLLPLEMDDAETGLLSAICLICGDRQDLEQPDRVDMLQEPLLEALKV 361
L + + + ++++ E L AI L D +E + V LQ+ L EAL+
Sbjct: 319 LLDLNNAILQLVKKYKSMKLEKEEFVTLKAIALANSDSMHIEDVEAVQKLQDVLHEALQD 378
Query: 362 YVRKRRPSRPHMFPKMLMKITDLRSISAKGAERVITLKMEIPGSMPPLIQEMLE 415
Y + P KMLM + LR S K + +K+E M L EMLE
Sbjct: 379 YEAGQHMEDPRRAGKMLMTLPLLRQTSTKAVQHFYNIKLEGKVPMHKLFLEMLE 432
>gi|45545427 estrogen-related receptor gamma isoform 2 [Homo
sapiens]
Length = 435
Score = 188 bits (477), Expect = 1e-47
Identities = 129/414 (31%), Positives = 197/414 (47%), Gaps = 26/414 (6%)
Query: 5 SSSCPTPGGGHLNGYPVPPYAFFFPPMLGGLSPPGALTTLQHQLPVSGYSTPSPATIETQ 64
S S + GH NG PP + P+LGG P L Y S +E
Sbjct: 42 SGSYSSTMNGHQNGLDSPPL-YPSAPILGGSGPVRKL-----------YDDCSSTIVEDP 89
Query: 65 SSSSEEIVPSPPSPPPLPRIYKPCFVCQDKSSGYHYGVSACEGCKGFFRRSIQKNMVYTC 124
+ E ++ S P + C VC D +SGYHYGV++CE CK FF+R+IQ N+ Y+C
Sbjct: 90 QTKCEYMLNSMPK--------RLCLVCGDIASGYHYGVASCEACKAFFKRTIQGNIEYSC 141
Query: 125 HRDKNCIINKVTRNRCQYCRLQKCFEVGMSKESVRNDRNK--KKKEVPKPECSESYTLTP 182
C I K R CQ CR KC +VGM KE VR DR + ++K + + S L P
Sbjct: 142 PATNECEITKRRRKSCQACRFMKCLKVGMLKEGVRLDRVRGGRQKYKRRIDAENSPYLNP 201
Query: 183 EVGELIEKVRKAHQETFPALCQLGKYTTNNSSEQRV-SLDIDLWDKFSELSTKCIIKTVE 241
+L++ +K + + L + V DI +L+ + ++ +
Sbjct: 202 ---QLVQPAKKPYNKIVSHLLVAEPEKIYAMPDPTVPDSDIKALTTLCDLADRELVVIIG 258
Query: 242 FAKQLPGFTTLTIADQITLLKAACLDILILRICTRYTPEQDTMTFSDGLTLNRTQMHNAG 301
+AK +PGF+TL++ADQ++LL++A ++ILIL + R +D + ++D ++ Q AG
Sbjct: 259 WAKHIPGFSTLSLADQMSLLQSAWMEILILGVVYRSLSFEDELVYADDYIMDEDQSKLAG 318
Query: 302 FGPLTDLVFAFANQLLPLEMDDAETGLLSAICLICGDRQDLEQPDRVDMLQEPLLEALKV 361
L + + + ++++ E L AI L D +E + V LQ+ L EAL+
Sbjct: 319 LLDLNNAILQLVKKYKSMKLEKEEFVTLKAIALANSDSMHIEDVEAVQKLQDVLHEALQD 378
Query: 362 YVRKRRPSRPHMFPKMLMKITDLRSISAKGAERVITLKMEIPGSMPPLIQEMLE 415
Y + P KMLM + LR S K + +K+E M L EMLE
Sbjct: 379 YEAGQHMEDPRRAGKMLMTLPLLRQTSTKAVQHFYNIKLEGKVPMHKLFLEMLE 432
>gi|45545433 estrogen-related receptor gamma isoform 1 [Homo
sapiens]
Length = 458
Score = 188 bits (477), Expect = 1e-47
Identities = 129/414 (31%), Positives = 197/414 (47%), Gaps = 26/414 (6%)
Query: 5 SSSCPTPGGGHLNGYPVPPYAFFFPPMLGGLSPPGALTTLQHQLPVSGYSTPSPATIETQ 64
S S + GH NG PP + P+LGG P L Y S +E
Sbjct: 65 SGSYSSTMNGHQNGLDSPPL-YPSAPILGGSGPVRKL-----------YDDCSSTIVEDP 112
Query: 65 SSSSEEIVPSPPSPPPLPRIYKPCFVCQDKSSGYHYGVSACEGCKGFFRRSIQKNMVYTC 124
+ E ++ S P + C VC D +SGYHYGV++CE CK FF+R+IQ N+ Y+C
Sbjct: 113 QTKCEYMLNSMPK--------RLCLVCGDIASGYHYGVASCEACKAFFKRTIQGNIEYSC 164
Query: 125 HRDKNCIINKVTRNRCQYCRLQKCFEVGMSKESVRNDRNK--KKKEVPKPECSESYTLTP 182
C I K R CQ CR KC +VGM KE VR DR + ++K + + S L P
Sbjct: 165 PATNECEITKRRRKSCQACRFMKCLKVGMLKEGVRLDRVRGGRQKYKRRIDAENSPYLNP 224
Query: 183 EVGELIEKVRKAHQETFPALCQLGKYTTNNSSEQRV-SLDIDLWDKFSELSTKCIIKTVE 241
+L++ +K + + L + V DI +L+ + ++ +
Sbjct: 225 ---QLVQPAKKPYNKIVSHLLVAEPEKIYAMPDPTVPDSDIKALTTLCDLADRELVVIIG 281
Query: 242 FAKQLPGFTTLTIADQITLLKAACLDILILRICTRYTPEQDTMTFSDGLTLNRTQMHNAG 301
+AK +PGF+TL++ADQ++LL++A ++ILIL + R +D + ++D ++ Q AG
Sbjct: 282 WAKHIPGFSTLSLADQMSLLQSAWMEILILGVVYRSLSFEDELVYADDYIMDEDQSKLAG 341
Query: 302 FGPLTDLVFAFANQLLPLEMDDAETGLLSAICLICGDRQDLEQPDRVDMLQEPLLEALKV 361
L + + + ++++ E L AI L D +E + V LQ+ L EAL+
Sbjct: 342 LLDLNNAILQLVKKYKSMKLEKEEFVTLKAIALANSDSMHIEDVEAVQKLQDVLHEALQD 401
Query: 362 YVRKRRPSRPHMFPKMLMKITDLRSISAKGAERVITLKMEIPGSMPPLIQEMLE 415
Y + P KMLM + LR S K + +K+E M L EMLE
Sbjct: 402 YEAGQHMEDPRRAGKMLMTLPLLRQTSTKAVQHFYNIKLEGKVPMHKLFLEMLE 455
>gi|197209821 estrogen-related receptor gamma isoform 2 [Homo
sapiens]
Length = 435
Score = 188 bits (477), Expect = 1e-47
Identities = 129/414 (31%), Positives = 197/414 (47%), Gaps = 26/414 (6%)
Query: 5 SSSCPTPGGGHLNGYPVPPYAFFFPPMLGGLSPPGALTTLQHQLPVSGYSTPSPATIETQ 64
S S + GH NG PP + P+LGG P L Y S +E
Sbjct: 42 SGSYSSTMNGHQNGLDSPPL-YPSAPILGGSGPVRKL-----------YDDCSSTIVEDP 89
Query: 65 SSSSEEIVPSPPSPPPLPRIYKPCFVCQDKSSGYHYGVSACEGCKGFFRRSIQKNMVYTC 124
+ E ++ S P + C VC D +SGYHYGV++CE CK FF+R+IQ N+ Y+C
Sbjct: 90 QTKCEYMLNSMPK--------RLCLVCGDIASGYHYGVASCEACKAFFKRTIQGNIEYSC 141
Query: 125 HRDKNCIINKVTRNRCQYCRLQKCFEVGMSKESVRNDRNK--KKKEVPKPECSESYTLTP 182
C I K R CQ CR KC +VGM KE VR DR + ++K + + S L P
Sbjct: 142 PATNECEITKRRRKSCQACRFMKCLKVGMLKEGVRLDRVRGGRQKYKRRIDAENSPYLNP 201
Query: 183 EVGELIEKVRKAHQETFPALCQLGKYTTNNSSEQRV-SLDIDLWDKFSELSTKCIIKTVE 241
+L++ +K + + L + V DI +L+ + ++ +
Sbjct: 202 ---QLVQPAKKPYNKIVSHLLVAEPEKIYAMPDPTVPDSDIKALTTLCDLADRELVVIIG 258
Query: 242 FAKQLPGFTTLTIADQITLLKAACLDILILRICTRYTPEQDTMTFSDGLTLNRTQMHNAG 301
+AK +PGF+TL++ADQ++LL++A ++ILIL + R +D + ++D ++ Q AG
Sbjct: 259 WAKHIPGFSTLSLADQMSLLQSAWMEILILGVVYRSLSFEDELVYADDYIMDEDQSKLAG 318
Query: 302 FGPLTDLVFAFANQLLPLEMDDAETGLLSAICLICGDRQDLEQPDRVDMLQEPLLEALKV 361
L + + + ++++ E L AI L D +E + V LQ+ L EAL+
Sbjct: 319 LLDLNNAILQLVKKYKSMKLEKEEFVTLKAIALANSDSMHIEDVEAVQKLQDVLHEALQD 378
Query: 362 YVRKRRPSRPHMFPKMLMKITDLRSISAKGAERVITLKMEIPGSMPPLIQEMLE 415
Y + P KMLM + LR S K + +K+E M L EMLE
Sbjct: 379 YEAGQHMEDPRRAGKMLMTLPLLRQTSTKAVQHFYNIKLEGKVPMHKLFLEMLE 432
>gi|20070199 nuclear receptor subfamily 2, group F, member 6 [Homo
sapiens]
Length = 404
Score = 176 bits (447), Expect = 3e-44
Identities = 134/402 (33%), Positives = 195/402 (48%), Gaps = 37/402 (9%)
Query: 33 GGLSPPGALTTLQHQLPVSGYSTPSPATIETQSSSSEEIVP-SPPSPPPLPRIYKPCFVC 91
GG PG T + GY P E S+S + P P + C VC
Sbjct: 6 GGWGGPGGDTNGVDK--AGGY----PRAAEDDSASPPGAASDAEPGDEERPGLQVDCVVC 59
Query: 92 QDKSSGYHYGVSACEGCKGFFRRSIQKNMVYTCHRDKNCIINKVTRNRCQYCRLQKCFEV 151
DKSSG HYGV CEGCK FF+RSI++N+ YTC +++C I++ RN+CQYCRL+KCF V
Sbjct: 60 GDKSSGKHYGVFTCEGCKSFFKRSIRRNLSYTCRSNRDCQIDQHHRNQCQYCRLKKCFRV 119
Query: 152 GMSKESVRNDRNKKKKEVPKPECSESYT--------------LTP--EVGELIEKVRKAH 195
GM KE+V+ R + +P + S + L P V ELI ++ +A
Sbjct: 120 GMRKEAVQ--RGRIPHSLPGAVAASSGSPPGSALAAVASGGDLFPGQPVSELIAQLLRA- 176
Query: 196 QETFPALCQLGKYTTNNSSEQRVSLDIDLWDKFSELSTKCIIKTVEFAKQLPGFTTLTIA 255
E +PA G++ + V L ID EL+ + + TVE+A+ P F L +A
Sbjct: 177 -EPYPAAA--GRFGAGGGAAGAV-LGID---NVCELAARLLFSTVEWARHAPFFPELPVA 229
Query: 256 DQITLLKAACLDILILRICTRYTPEQDTMTFSDGLTLNRTQMHNAGFGPLTDLVFAFANQ 315
DQ+ LL+ + ++ +L P T L+ M D V AF Q
Sbjct: 230 DQVALLRLSWSELFVLNAAQAALPLH-TAPLLAAAGLHAAPMAAERAVAFMDQVRAFQEQ 288
Query: 316 ---LLPLEMDDAETGLLSAICLICGDRQDLEQPDRVDMLQEPLLEALKVYVRKRRPSRPH 372
L L++D AE G L AI L D L P V+ LQE AL YVR + PS+P
Sbjct: 289 VDKLGRLQVDSAEYGCLKAIALFTPDACGLSDPAHVESLQEKAQVALTEYVRAQYPSQPQ 348
Query: 373 MFPKMLMKITDLRSISAKGAERVITLKMEIPGSMPPLIQEML 414
F ++L+++ LR++ A ++ +++ + LI++ML
Sbjct: 349 RFGRLLLRLPALRAVPASLISQLFFMRLVGKTPIETLIRDML 390
Database: hs.faa
Posted date: Aug 4, 2009 4:42 PM
Number of letters in database: 18,247,518
Number of sequences in database: 37,866
Lambda K H
0.317 0.135 0.409
Gapped
Lambda K H
0.267 0.0410 0.140
Matrix: BLOSUM62
Gap Penalties: Existence: 11, Extension: 1
Number of Hits to DB: 21,914,978
Number of Sequences: 37866
Number of extensions: 1223526
Number of successful extensions: 11217
Number of sequences better than 10.0: 30
Number of HSP's better than 10.0 without gapping: 162
Number of HSP's successfully gapped in prelim test: 181
Number of HSP's that attempted gapping in prelim test: 9768
Number of HSP's gapped (non-prelim): 1387
length of query: 462
length of database: 18,247,518
effective HSP length: 106
effective length of query: 356
effective length of database: 14,233,722
effective search space: 5067205032
effective search space used: 5067205032
T: 11
A: 40
X1: 16 ( 7.3 bits)
X2: 38 (14.6 bits)
X3: 64 (24.7 bits)
S1: 41 (21.6 bits)
S2: 64 (29.3 bits)
Search results were obtained with NCBI BLAST and RefSeq entries.
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Guide to the Human Genome
Copyright © 2010 by Stewart Scherer. All rights reserved.