Guide to the Human Genome
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Search of human proteins with 223468634

BLASTP 2.2.11 [Jun-05-2005]


Reference: Altschul, Stephen F., Thomas L. Madden, Alejandro A. Schaffer, 
Jinghui Zhang, Zheng Zhang, Webb Miller, and David J. Lipman (1997), 
"Gapped BLAST and PSI-BLAST: a new generation of protein database search
programs",  Nucleic Acids Res. 25:3389-3402.

Query= gi|223468634 envoplakin-like [Homo sapiens]
         (301 letters)

Database: hs.faa 
           37,866 sequences; 18,247,518 total letters

Searching..................................................done

                                                                 Score    E
Sequences producing significant alignments:                      (bits) Value

gi|223468634 envoplakin-like [Homo sapiens]                           617   e-177
gi|156104874 envoplakin [Homo sapiens]                                377   e-105
gi|45439327 periplakin [Homo sapiens]                                 122   4e-28
gi|41322923 plectin 1 isoform 11 [Homo sapiens]                        64   2e-10
gi|41322914 plectin 1 isoform 10 [Homo sapiens]                        64   2e-10
gi|41322919 plectin 1 isoform 8 [Homo sapiens]                         64   2e-10
gi|41322910 plectin 1 isoform 7 [Homo sapiens]                         64   2e-10
gi|41322916 plectin 1 isoform 6 [Homo sapiens]                         64   2e-10
gi|41322908 plectin 1 isoform 3 [Homo sapiens]                         64   2e-10
gi|41322912 plectin 1 isoform 2 [Homo sapiens]                         64   2e-10
gi|47607492 plectin 1 isoform 1 [Homo sapiens]                         64   2e-10
gi|169218211 PREDICTED: similar to plectin 1, partial [Homo sapi...    63   4e-10
gi|221316624 dystonin isoform 4 [Homo sapiens]                         47   2e-05
gi|221316622 dystonin isoform 3 [Homo sapiens]                         47   2e-05
gi|221316618 dystonin isoform 2 [Homo sapiens]                         47   2e-05
gi|34577047 dystonin isoform 1 [Homo sapiens]                          47   2e-05
gi|20357504 dystonin isoform 1eB precursor [Homo sapiens]              47   2e-05
gi|34577049 dystonin isoform 1eA precursor [Homo sapiens]              47   2e-05
gi|4502443 dystonin isoform 1e precursor [Homo sapiens]                47   2e-05
gi|58530842 desmoplakin isoform II [Homo sapiens]                      44   2e-04
gi|58530840 desmoplakin isoform I [Homo sapiens]                       44   2e-04
gi|33188445 microfilament and actin filament cross-linker protei...    41   0.001
gi|56549694 enabled homolog isoform a [Homo sapiens]                   39   0.006
gi|39930375 enabled homolog isoform b [Homo sapiens]                   39   0.006
gi|4503509 eukaryotic translation initiation factor 3, subunit 1...    37   0.021
gi|153791497 ciliary rootlet coiled-coil [Homo sapiens]                37   0.028
gi|92091575 coiled-coil domain containing 57 [Homo sapiens]            36   0.036
gi|110349772 alpha 1 type I collagen preproprotein [Homo sapiens]      36   0.048
gi|4507831 Unc-51-like kinase 1 [Homo sapiens]                         35   0.062
gi|169171388 PREDICTED: hypothetical protein [Homo sapiens]            35   0.081

>gi|223468634 envoplakin-like [Homo sapiens]
          Length = 301

 Score =  617 bits (1592), Expect = e-177
 Identities = 301/301 (100%), Positives = 301/301 (100%)

Query: 1   MQASADQVERDILETQKRLQQDRLNSEQSQALQHQQETGSSLKEAEVLLKDLFLDVDKAR 60
           MQASADQVERDILETQKRLQQDRLNSEQSQALQHQQETGSSLKEAEVLLKDLFLDVDKAR
Sbjct: 1   MQASADQVERDILETQKRLQQDRLNSEQSQALQHQQETGSSLKEAEVLLKDLFLDVDKAR 60

Query: 61  RLKHPQAEETEKDIEQLHERVTQECAEYCALYEKMVLPPRRGIQGRLGTRAGAETEAGLR 120
           RLKHPQAEETEKDIEQLHERVTQECAEYCALYEKMVLPPRRGIQGRLGTRAGAETEAGLR
Sbjct: 61  RLKHPQAEETEKDIEQLHERVTQECAEYCALYEKMVLPPRRGIQGRLGTRAGAETEAGLR 120

Query: 121 RPVWAGHGGAGGTDRGAQHRAEGDQRPRRAAAEPGGAGCRHHPEPIPRPTEGGVVARAEP 180
           RPVWAGHGGAGGTDRGAQHRAEGDQRPRRAAAEPGGAGCRHHPEPIPRPTEGGVVARAEP
Sbjct: 121 RPVWAGHGGAGGTDRGAQHRAEGDQRPRRAAAEPGGAGCRHHPEPIPRPTEGGVVARAEP 180

Query: 181 GQPVHALQGCTWQLSALAEQQRRILQQDWSDLMADPAGVRREYEHFKQHELLSQEQSVNQ 240
           GQPVHALQGCTWQLSALAEQQRRILQQDWSDLMADPAGVRREYEHFKQHELLSQEQSVNQ
Sbjct: 181 GQPVHALQGCTWQLSALAEQQRRILQQDWSDLMADPAGVRREYEHFKQHELLSQEQSVNQ 240

Query: 241 LEEDGKRMVELRHPAVGPIQAHQEALKMEWQNFLNLCICQETQLQHVEDYSRILCPSSSP 300
           LEEDGKRMVELRHPAVGPIQAHQEALKMEWQNFLNLCICQETQLQHVEDYSRILCPSSSP
Sbjct: 241 LEEDGKRMVELRHPAVGPIQAHQEALKMEWQNFLNLCICQETQLQHVEDYSRILCPSSSP 300

Query: 301 H 301
           H
Sbjct: 301 H 301


>gi|156104874 envoplakin [Homo sapiens]
          Length = 2033

 Score =  377 bits (969), Expect = e-105
 Identities = 216/307 (70%), Positives = 232/307 (75%), Gaps = 30/307 (9%)

Query: 1   MQASADQVERDILETQKRLQQDRLNSEQSQALQHQQETGSSLKEAEVLLKDLFLDVDKAR 60
           MQA+ADQVERDILETQKRLQQDRLNSEQSQALQHQQETG SLKEAEVLLKDLFLDVDKAR
Sbjct: 46  MQANADQVERDILETQKRLQQDRLNSEQSQALQHQQETGRSLKEAEVLLKDLFLDVDKAR 105

Query: 61  RLKHPQAEETEKDIEQLHERVTQECAEYCALYEKMVLPPRRGIQGRLGTRAG-AETEAGL 119
           RLKHPQAEE EKDI+QLHERVTQECAEY ALYEKMVLPP       +G R   A      
Sbjct: 106 RLKHPQAEEIEKDIKQLHERVTQECAEYRALYEKMVLPPD------VGPRVDWARVLEQK 159

Query: 120 RRPVWAGHGGAGGTD---RGAQHR-------AEGDQRPRRAAAEPGGAGCRHHPEPIPRP 169
           ++ V AG  G G  +   + A+H        A G Q   R+   P  A  R     + + 
Sbjct: 160 QKQVCAGQYGPGMAELEQQIAEHNILQKEIDAYGQQL--RSLVGPDAATIRSQYRDLLK- 216

Query: 170 TEGGVVARAEPGQPVHAL----QGCTWQLSALAEQQRRILQQDWSDLMADPAGVRREYEH 225
                 A +  GQ + +L    QGCT QLSALAEQQRRILQQDWSDLMADPAGVRREYEH
Sbjct: 217 ------AASWRGQSLGSLYTHLQGCTRQLSALAEQQRRILQQDWSDLMADPAGVRREYEH 270

Query: 226 FKQHELLSQEQSVNQLEEDGKRMVELRHPAVGPIQAHQEALKMEWQNFLNLCICQETQLQ 285
           FKQHELLSQEQSVNQLE+DG+RMVELRHPAVGPIQAHQEALKMEWQNFLNLCICQETQLQ
Sbjct: 271 FKQHELLSQEQSVNQLEDDGERMVELRHPAVGPIQAHQEALKMEWQNFLNLCICQETQLQ 330

Query: 286 HVEDYSR 292
           HVEDY R
Sbjct: 331 HVEDYRR 337


>gi|45439327 periplakin [Homo sapiens]
          Length = 1756

 Score =  122 bits (306), Expect = 4e-28
 Identities = 83/299 (27%), Positives = 147/299 (49%), Gaps = 19/299 (6%)

Query: 1   MQASADQVERDILETQKRLQQDRLNSEQSQALQHQQETGSSLKEAEVLLKDLFLDVDKAR 60
           +Q +ADQVE++I++T+ ++Q D    ++ +  +H+  T   + ++E LL  L  D   A+
Sbjct: 34  LQKNADQVEKNIVDTEAKMQSDLARLQEGRQPEHRDVTLQKVLDSEKLLYVLEADAAIAK 93

Query: 61  RLKHPQAEETEKDIEQLHERVTQECAEYCALYEKMVLPPRRGIQGRLGTRAGAETEAGLR 120
            +KHPQ +   +DI QL ERVT    ++  +Y   V    + +  ++   A  E +    
Sbjct: 94  HMKHPQGDMIAEDIRQLKERVTNLRGKHKQIYRLAV----KEVDPQVNWAALVEEKLDKL 149

Query: 121 RPVWAGHGGAGGTDRG-AQHRAEG----DQRPRRAAAEPGGAGCRHHPEPIPRPTEGGVV 175
                 +  + GTD     H+ E         +         G +     +    +  + 
Sbjct: 150 ------NNQSFGTDLPLVDHQVEEHNIFHNEVKAIGPHLAKDGDKEQNSELRAKYQKLLA 203

Query: 176 ARAEPGQPVHALQG----CTWQLSALAEQQRRILQQDWSDLMADPAGVRREYEHFKQHEL 231
           A     Q + +LQ     CT +L  L +Q +  +Q DWSD   D    RR+YE+F    L
Sbjct: 204 ASQARQQHLSSLQDYMQRCTNELYWLDQQAKGRMQYDWSDRNLDYPSRRRQYENFINRNL 263

Query: 232 LSQEQSVNQLEEDGKRMVELRHPAVGPIQAHQEALKMEWQNFLNLCICQETQLQHVEDY 290
            ++E+ +N+L  +G +++   HP    I+AH EA+  +W+ +LNL IC+E+ L+++EDY
Sbjct: 264 EAKEERINKLHSEGDQLLAAEHPGRNSIEAHMEAVHADWKEYLNLLICEESHLKYMEDY 322


>gi|41322923 plectin 1 isoform 11 [Homo sapiens]
          Length = 4547

 Score = 63.5 bits (153), Expect = 2e-10
 Identities = 72/332 (21%), Positives = 118/332 (35%), Gaps = 50/332 (15%)

Query: 1   MQASADQVERDILETQKRLQQDRLNSEQSQALQHQQETGSSLKEAEVLLKDLFLDVDKAR 60
           +Q  A   E  + +    LQ D       +  Q   E    L +A+ +++ LF DV   +
Sbjct: 401 LQMEAGLCEEQLNQADALLQSDVRLLAAGKVPQRAGEVERDLDKADSMIRLLFNDVQTLK 460

Query: 61  RLKHPQAEETEKDIEQLHERVTQECAEYCALYEKMVLPPRRGIQGRLGTRAGAETEAGLR 120
             +HPQ E+  + + +LHER+     EY    +  V  P   +       A    ++  R
Sbjct: 461 DGRHPQGEQMYRRVYRLHERLVAIRTEYNLRLKAGVAAPATQV-------AQVTLQSVQR 513

Query: 121 RP--------------VWAGH------GGAGGTD---------------------RGAQH 139
           RP               W         G   G D                     R    
Sbjct: 514 RPELEDSTLRYLQDLLAWVEENQHRVDGAEWGVDLPSVEAQLGSHRGLHQSIEEFRAKIE 573

Query: 140 RAEGDQRPRRAAAEPGGAGCRHHPEPIPRPTEGGVVARAEPGQPVHA-LQGCTWQLSALA 198
           RA  D+     A       C    +           AR    + +H+ +   T +L  L 
Sbjct: 574 RARSDEGQLSPATRGAYRDCLGRLDLQYAKLLNSSKARLRSLESLHSFVAAATKELMWLN 633

Query: 199 EQQRRILQQDWSDLMADPAGVRREYEHFKQHELLSQEQSVNQLEEDGKRMVELRHPAVGP 258
           E++   +  DWSD   +    +  Y    + EL  +E+ + +L+  G R++   HPA   
Sbjct: 634 EKEEEEVGFDWSDRNTNMTAKKESYSALMR-ELELKEKKIKELQNAGDRLLREDHPARPT 692

Query: 259 IQAHQEALKMEWQNFLNLCICQETQLQHVEDY 290
           +++ Q AL+ +W   L LC C E  L+    Y
Sbjct: 693 VESFQAALQTQWSWMLQLCCCIEAHLKENAAY 724



 Score = 31.2 bits (69), Expect = 1.2
 Identities = 58/264 (21%), Positives = 102/264 (38%), Gaps = 34/264 (12%)

Query: 2    QASADQVERDILETQKRLQQDRLNSEQSQALQHQQETGSSLKEAEVLLKDLFLDVDKARR 61
            QA A Q ER+  E Q+R+Q++ +  E++ A+  QQ+  S  +E + L +    ++    R
Sbjct: 1381 QAKA-QAEREAKELQQRMQEEVVRREEA-AVDAQQQKRSIQEELQQLRQSSEAEIQAKAR 1438

Query: 62   LKHPQAEETEKDIEQLHERVTQECAEYCALYEKMVLPPRRGIQGRL-GTRAGAETEAGLR 120
                QAE  E+   ++ E +         L  +     R G +G L   RA AE     +
Sbjct: 1439 ----QAEAAERSRLRIEEEI-----RVVRLQLEATERQRGGAEGELQALRARAEEAEAQK 1489

Query: 121  RPVWAGHGGAGGTDRGAQHRAEGDQRPRRAAAEPGGAGCRHHPEPIPRPTEGGVVARAEP 180
            R            +R  +   +  QR R+A  E            +    +    A  E 
Sbjct: 1490 RQ------AQEEAERLRRQVQDESQRKRQAEVE------------LASRVKAEAEAAREK 1531

Query: 181  GQPVHALQGCTWQLSALAEQQRRILQQDWSDLMADPAGVRREYEHFKQHELLSQEQSVNQ 240
             + + AL+    +L   AE+  R L+Q   +            +   + EL S+  S  +
Sbjct: 1532 QRALQALE----ELRLQAEEAERRLRQAEVERARQVQVALETAQRSAEAELQSKRASFAE 1587

Query: 241  LEEDGKRMVELRHPAVGPIQAHQE 264
                 +R ++  H AV  ++   E
Sbjct: 1588 KTAQLERSLQEEHVAVAQLREEAE 1611



 Score = 31.2 bits (69), Expect = 1.2
 Identities = 62/251 (24%), Positives = 95/251 (37%), Gaps = 40/251 (15%)

Query: 7    QVERDILETQKRLQQDRLNSEQSQALQHQQETGSSLKEAEVLLKDLFLDVDKARRLKHPQ 66
            Q+ER + E    + Q  L  E  +  Q Q E   + +EAE  L+   L  ++A RL+  Q
Sbjct: 1591 QLERSLQEEHVAVAQ--LREEAERRAQQQAEAERAREEAERELERWQLKANEALRLR-LQ 1647

Query: 67   AEET--EKDIEQLHERVTQECAEYCALYEKMVLPPRRGIQGRLGTRAGAETEAGLRRPVW 124
            AEE   +K + Q      +E AE  A         RRG       R     E  L +   
Sbjct: 1648 AEEVAQQKSLAQAEAEKQKEEAEREA--------RRRGKAEEQAVRQRELAEQELEKQRQ 1699

Query: 125  AGHGGAGGTDRGAQHRAEGDQRPRRAAAEPGGAGCRHHPEPIPRPTEGGVVARAEPGQPV 184
               G        AQ R   +Q   R  AE                TE G   R    + +
Sbjct: 1700 LAEG-------TAQQRLAAEQELIRLRAE----------------TEQGEQQRQLLEEEL 1736

Query: 185  HALQGCTWQLSALAEQQRRILQQDWSDLMADPAGVRREYEHFKQHELLSQEQSVNQLEED 244
              LQ    + +A A Q+R+ L+ + + + A+   +       ++    + E+S  +LE +
Sbjct: 1737 ARLQ----REAAAATQKRQELEAELAKVRAEMEVLLASKARAEEESRSTSEKSKQRLEAE 1792

Query: 245  GKRMVELRHPA 255
              R  EL   A
Sbjct: 1793 AGRFRELAEEA 1803


>gi|41322914 plectin 1 isoform 10 [Homo sapiens]
          Length = 4551

 Score = 63.5 bits (153), Expect = 2e-10
 Identities = 72/332 (21%), Positives = 118/332 (35%), Gaps = 50/332 (15%)

Query: 1   MQASADQVERDILETQKRLQQDRLNSEQSQALQHQQETGSSLKEAEVLLKDLFLDVDKAR 60
           +Q  A   E  + +    LQ D       +  Q   E    L +A+ +++ LF DV   +
Sbjct: 405 LQMEAGLCEEQLNQADALLQSDVRLLAAGKVPQRAGEVERDLDKADSMIRLLFNDVQTLK 464

Query: 61  RLKHPQAEETEKDIEQLHERVTQECAEYCALYEKMVLPPRRGIQGRLGTRAGAETEAGLR 120
             +HPQ E+  + + +LHER+     EY    +  V  P   +       A    ++  R
Sbjct: 465 DGRHPQGEQMYRRVYRLHERLVAIRTEYNLRLKAGVAAPATQV-------AQVTLQSVQR 517

Query: 121 RP--------------VWAGH------GGAGGTD---------------------RGAQH 139
           RP               W         G   G D                     R    
Sbjct: 518 RPELEDSTLRYLQDLLAWVEENQHRVDGAEWGVDLPSVEAQLGSHRGLHQSIEEFRAKIE 577

Query: 140 RAEGDQRPRRAAAEPGGAGCRHHPEPIPRPTEGGVVARAEPGQPVHA-LQGCTWQLSALA 198
           RA  D+     A       C    +           AR    + +H+ +   T +L  L 
Sbjct: 578 RARSDEGQLSPATRGAYRDCLGRLDLQYAKLLNSSKARLRSLESLHSFVAAATKELMWLN 637

Query: 199 EQQRRILQQDWSDLMADPAGVRREYEHFKQHELLSQEQSVNQLEEDGKRMVELRHPAVGP 258
           E++   +  DWSD   +    +  Y    + EL  +E+ + +L+  G R++   HPA   
Sbjct: 638 EKEEEEVGFDWSDRNTNMTAKKESYSALMR-ELELKEKKIKELQNAGDRLLREDHPARPT 696

Query: 259 IQAHQEALKMEWQNFLNLCICQETQLQHVEDY 290
           +++ Q AL+ +W   L LC C E  L+    Y
Sbjct: 697 VESFQAALQTQWSWMLQLCCCIEAHLKENAAY 728



 Score = 31.2 bits (69), Expect = 1.2
 Identities = 58/264 (21%), Positives = 102/264 (38%), Gaps = 34/264 (12%)

Query: 2    QASADQVERDILETQKRLQQDRLNSEQSQALQHQQETGSSLKEAEVLLKDLFLDVDKARR 61
            QA A Q ER+  E Q+R+Q++ +  E++ A+  QQ+  S  +E + L +    ++    R
Sbjct: 1385 QAKA-QAEREAKELQQRMQEEVVRREEA-AVDAQQQKRSIQEELQQLRQSSEAEIQAKAR 1442

Query: 62   LKHPQAEETEKDIEQLHERVTQECAEYCALYEKMVLPPRRGIQGRL-GTRAGAETEAGLR 120
                QAE  E+   ++ E +         L  +     R G +G L   RA AE     +
Sbjct: 1443 ----QAEAAERSRLRIEEEI-----RVVRLQLEATERQRGGAEGELQALRARAEEAEAQK 1493

Query: 121  RPVWAGHGGAGGTDRGAQHRAEGDQRPRRAAAEPGGAGCRHHPEPIPRPTEGGVVARAEP 180
            R            +R  +   +  QR R+A  E            +    +    A  E 
Sbjct: 1494 RQ------AQEEAERLRRQVQDESQRKRQAEVE------------LASRVKAEAEAAREK 1535

Query: 181  GQPVHALQGCTWQLSALAEQQRRILQQDWSDLMADPAGVRREYEHFKQHELLSQEQSVNQ 240
             + + AL+    +L   AE+  R L+Q   +            +   + EL S+  S  +
Sbjct: 1536 QRALQALE----ELRLQAEEAERRLRQAEVERARQVQVALETAQRSAEAELQSKRASFAE 1591

Query: 241  LEEDGKRMVELRHPAVGPIQAHQE 264
                 +R ++  H AV  ++   E
Sbjct: 1592 KTAQLERSLQEEHVAVAQLREEAE 1615



 Score = 31.2 bits (69), Expect = 1.2
 Identities = 62/251 (24%), Positives = 95/251 (37%), Gaps = 40/251 (15%)

Query: 7    QVERDILETQKRLQQDRLNSEQSQALQHQQETGSSLKEAEVLLKDLFLDVDKARRLKHPQ 66
            Q+ER + E    + Q  L  E  +  Q Q E   + +EAE  L+   L  ++A RL+  Q
Sbjct: 1595 QLERSLQEEHVAVAQ--LREEAERRAQQQAEAERAREEAERELERWQLKANEALRLR-LQ 1651

Query: 67   AEET--EKDIEQLHERVTQECAEYCALYEKMVLPPRRGIQGRLGTRAGAETEAGLRRPVW 124
            AEE   +K + Q      +E AE  A         RRG       R     E  L +   
Sbjct: 1652 AEEVAQQKSLAQAEAEKQKEEAEREA--------RRRGKAEEQAVRQRELAEQELEKQRQ 1703

Query: 125  AGHGGAGGTDRGAQHRAEGDQRPRRAAAEPGGAGCRHHPEPIPRPTEGGVVARAEPGQPV 184
               G        AQ R   +Q   R  AE                TE G   R    + +
Sbjct: 1704 LAEG-------TAQQRLAAEQELIRLRAE----------------TEQGEQQRQLLEEEL 1740

Query: 185  HALQGCTWQLSALAEQQRRILQQDWSDLMADPAGVRREYEHFKQHELLSQEQSVNQLEED 244
              LQ    + +A A Q+R+ L+ + + + A+   +       ++    + E+S  +LE +
Sbjct: 1741 ARLQ----REAAAATQKRQELEAELAKVRAEMEVLLASKARAEEESRSTSEKSKQRLEAE 1796

Query: 245  GKRMVELRHPA 255
              R  EL   A
Sbjct: 1797 AGRFRELAEEA 1807


>gi|41322919 plectin 1 isoform 8 [Homo sapiens]
          Length = 4547

 Score = 63.5 bits (153), Expect = 2e-10
 Identities = 72/332 (21%), Positives = 118/332 (35%), Gaps = 50/332 (15%)

Query: 1   MQASADQVERDILETQKRLQQDRLNSEQSQALQHQQETGSSLKEAEVLLKDLFLDVDKAR 60
           +Q  A   E  + +    LQ D       +  Q   E    L +A+ +++ LF DV   +
Sbjct: 401 LQMEAGLCEEQLNQADALLQSDVRLLAAGKVPQRAGEVERDLDKADSMIRLLFNDVQTLK 460

Query: 61  RLKHPQAEETEKDIEQLHERVTQECAEYCALYEKMVLPPRRGIQGRLGTRAGAETEAGLR 120
             +HPQ E+  + + +LHER+     EY    +  V  P   +       A    ++  R
Sbjct: 461 DGRHPQGEQMYRRVYRLHERLVAIRTEYNLRLKAGVAAPATQV-------AQVTLQSVQR 513

Query: 121 RP--------------VWAGH------GGAGGTD---------------------RGAQH 139
           RP               W         G   G D                     R    
Sbjct: 514 RPELEDSTLRYLQDLLAWVEENQHRVDGAEWGVDLPSVEAQLGSHRGLHQSIEEFRAKIE 573

Query: 140 RAEGDQRPRRAAAEPGGAGCRHHPEPIPRPTEGGVVARAEPGQPVHA-LQGCTWQLSALA 198
           RA  D+     A       C    +           AR    + +H+ +   T +L  L 
Sbjct: 574 RARSDEGQLSPATRGAYRDCLGRLDLQYAKLLNSSKARLRSLESLHSFVAAATKELMWLN 633

Query: 199 EQQRRILQQDWSDLMADPAGVRREYEHFKQHELLSQEQSVNQLEEDGKRMVELRHPAVGP 258
           E++   +  DWSD   +    +  Y    + EL  +E+ + +L+  G R++   HPA   
Sbjct: 634 EKEEEEVGFDWSDRNTNMTAKKESYSALMR-ELELKEKKIKELQNAGDRLLREDHPARPT 692

Query: 259 IQAHQEALKMEWQNFLNLCICQETQLQHVEDY 290
           +++ Q AL+ +W   L LC C E  L+    Y
Sbjct: 693 VESFQAALQTQWSWMLQLCCCIEAHLKENAAY 724



 Score = 31.2 bits (69), Expect = 1.2
 Identities = 58/264 (21%), Positives = 102/264 (38%), Gaps = 34/264 (12%)

Query: 2    QASADQVERDILETQKRLQQDRLNSEQSQALQHQQETGSSLKEAEVLLKDLFLDVDKARR 61
            QA A Q ER+  E Q+R+Q++ +  E++ A+  QQ+  S  +E + L +    ++    R
Sbjct: 1381 QAKA-QAEREAKELQQRMQEEVVRREEA-AVDAQQQKRSIQEELQQLRQSSEAEIQAKAR 1438

Query: 62   LKHPQAEETEKDIEQLHERVTQECAEYCALYEKMVLPPRRGIQGRL-GTRAGAETEAGLR 120
                QAE  E+   ++ E +         L  +     R G +G L   RA AE     +
Sbjct: 1439 ----QAEAAERSRLRIEEEI-----RVVRLQLEATERQRGGAEGELQALRARAEEAEAQK 1489

Query: 121  RPVWAGHGGAGGTDRGAQHRAEGDQRPRRAAAEPGGAGCRHHPEPIPRPTEGGVVARAEP 180
            R            +R  +   +  QR R+A  E            +    +    A  E 
Sbjct: 1490 RQ------AQEEAERLRRQVQDESQRKRQAEVE------------LASRVKAEAEAAREK 1531

Query: 181  GQPVHALQGCTWQLSALAEQQRRILQQDWSDLMADPAGVRREYEHFKQHELLSQEQSVNQ 240
             + + AL+    +L   AE+  R L+Q   +            +   + EL S+  S  +
Sbjct: 1532 QRALQALE----ELRLQAEEAERRLRQAEVERARQVQVALETAQRSAEAELQSKRASFAE 1587

Query: 241  LEEDGKRMVELRHPAVGPIQAHQE 264
                 +R ++  H AV  ++   E
Sbjct: 1588 KTAQLERSLQEEHVAVAQLREEAE 1611



 Score = 31.2 bits (69), Expect = 1.2
 Identities = 62/251 (24%), Positives = 95/251 (37%), Gaps = 40/251 (15%)

Query: 7    QVERDILETQKRLQQDRLNSEQSQALQHQQETGSSLKEAEVLLKDLFLDVDKARRLKHPQ 66
            Q+ER + E    + Q  L  E  +  Q Q E   + +EAE  L+   L  ++A RL+  Q
Sbjct: 1591 QLERSLQEEHVAVAQ--LREEAERRAQQQAEAERAREEAERELERWQLKANEALRLR-LQ 1647

Query: 67   AEET--EKDIEQLHERVTQECAEYCALYEKMVLPPRRGIQGRLGTRAGAETEAGLRRPVW 124
            AEE   +K + Q      +E AE  A         RRG       R     E  L +   
Sbjct: 1648 AEEVAQQKSLAQAEAEKQKEEAEREA--------RRRGKAEEQAVRQRELAEQELEKQRQ 1699

Query: 125  AGHGGAGGTDRGAQHRAEGDQRPRRAAAEPGGAGCRHHPEPIPRPTEGGVVARAEPGQPV 184
               G        AQ R   +Q   R  AE                TE G   R    + +
Sbjct: 1700 LAEG-------TAQQRLAAEQELIRLRAE----------------TEQGEQQRQLLEEEL 1736

Query: 185  HALQGCTWQLSALAEQQRRILQQDWSDLMADPAGVRREYEHFKQHELLSQEQSVNQLEED 244
              LQ    + +A A Q+R+ L+ + + + A+   +       ++    + E+S  +LE +
Sbjct: 1737 ARLQ----REAAAATQKRQELEAELAKVRAEMEVLLASKARAEEESRSTSEKSKQRLEAE 1792

Query: 245  GKRMVELRHPA 255
              R  EL   A
Sbjct: 1793 AGRFRELAEEA 1803


>gi|41322910 plectin 1 isoform 7 [Homo sapiens]
          Length = 4515

 Score = 63.5 bits (153), Expect = 2e-10
 Identities = 72/332 (21%), Positives = 118/332 (35%), Gaps = 50/332 (15%)

Query: 1   MQASADQVERDILETQKRLQQDRLNSEQSQALQHQQETGSSLKEAEVLLKDLFLDVDKAR 60
           +Q  A   E  + +    LQ D       +  Q   E    L +A+ +++ LF DV   +
Sbjct: 369 LQMEAGLCEEQLNQADALLQSDVRLLAAGKVPQRAGEVERDLDKADSMIRLLFNDVQTLK 428

Query: 61  RLKHPQAEETEKDIEQLHERVTQECAEYCALYEKMVLPPRRGIQGRLGTRAGAETEAGLR 120
             +HPQ E+  + + +LHER+     EY    +  V  P   +       A    ++  R
Sbjct: 429 DGRHPQGEQMYRRVYRLHERLVAIRTEYNLRLKAGVAAPATQV-------AQVTLQSVQR 481

Query: 121 RP--------------VWAGH------GGAGGTD---------------------RGAQH 139
           RP               W         G   G D                     R    
Sbjct: 482 RPELEDSTLRYLQDLLAWVEENQHRVDGAEWGVDLPSVEAQLGSHRGLHQSIEEFRAKIE 541

Query: 140 RAEGDQRPRRAAAEPGGAGCRHHPEPIPRPTEGGVVARAEPGQPVHA-LQGCTWQLSALA 198
           RA  D+     A       C    +           AR    + +H+ +   T +L  L 
Sbjct: 542 RARSDEGQLSPATRGAYRDCLGRLDLQYAKLLNSSKARLRSLESLHSFVAAATKELMWLN 601

Query: 199 EQQRRILQQDWSDLMADPAGVRREYEHFKQHELLSQEQSVNQLEEDGKRMVELRHPAVGP 258
           E++   +  DWSD   +    +  Y    + EL  +E+ + +L+  G R++   HPA   
Sbjct: 602 EKEEEEVGFDWSDRNTNMTAKKESYSALMR-ELELKEKKIKELQNAGDRLLREDHPARPT 660

Query: 259 IQAHQEALKMEWQNFLNLCICQETQLQHVEDY 290
           +++ Q AL+ +W   L LC C E  L+    Y
Sbjct: 661 VESFQAALQTQWSWMLQLCCCIEAHLKENAAY 692



 Score = 31.2 bits (69), Expect = 1.2
 Identities = 58/264 (21%), Positives = 102/264 (38%), Gaps = 34/264 (12%)

Query: 2    QASADQVERDILETQKRLQQDRLNSEQSQALQHQQETGSSLKEAEVLLKDLFLDVDKARR 61
            QA A Q ER+  E Q+R+Q++ +  E++ A+  QQ+  S  +E + L +    ++    R
Sbjct: 1349 QAKA-QAEREAKELQQRMQEEVVRREEA-AVDAQQQKRSIQEELQQLRQSSEAEIQAKAR 1406

Query: 62   LKHPQAEETEKDIEQLHERVTQECAEYCALYEKMVLPPRRGIQGRL-GTRAGAETEAGLR 120
                QAE  E+   ++ E +         L  +     R G +G L   RA AE     +
Sbjct: 1407 ----QAEAAERSRLRIEEEI-----RVVRLQLEATERQRGGAEGELQALRARAEEAEAQK 1457

Query: 121  RPVWAGHGGAGGTDRGAQHRAEGDQRPRRAAAEPGGAGCRHHPEPIPRPTEGGVVARAEP 180
            R            +R  +   +  QR R+A  E            +    +    A  E 
Sbjct: 1458 RQ------AQEEAERLRRQVQDESQRKRQAEVE------------LASRVKAEAEAAREK 1499

Query: 181  GQPVHALQGCTWQLSALAEQQRRILQQDWSDLMADPAGVRREYEHFKQHELLSQEQSVNQ 240
             + + AL+    +L   AE+  R L+Q   +            +   + EL S+  S  +
Sbjct: 1500 QRALQALE----ELRLQAEEAERRLRQAEVERARQVQVALETAQRSAEAELQSKRASFAE 1555

Query: 241  LEEDGKRMVELRHPAVGPIQAHQE 264
                 +R ++  H AV  ++   E
Sbjct: 1556 KTAQLERSLQEEHVAVAQLREEAE 1579



 Score = 31.2 bits (69), Expect = 1.2
 Identities = 62/251 (24%), Positives = 95/251 (37%), Gaps = 40/251 (15%)

Query: 7    QVERDILETQKRLQQDRLNSEQSQALQHQQETGSSLKEAEVLLKDLFLDVDKARRLKHPQ 66
            Q+ER + E    + Q  L  E  +  Q Q E   + +EAE  L+   L  ++A RL+  Q
Sbjct: 1559 QLERSLQEEHVAVAQ--LREEAERRAQQQAEAERAREEAERELERWQLKANEALRLR-LQ 1615

Query: 67   AEET--EKDIEQLHERVTQECAEYCALYEKMVLPPRRGIQGRLGTRAGAETEAGLRRPVW 124
            AEE   +K + Q      +E AE  A         RRG       R     E  L +   
Sbjct: 1616 AEEVAQQKSLAQAEAEKQKEEAEREA--------RRRGKAEEQAVRQRELAEQELEKQRQ 1667

Query: 125  AGHGGAGGTDRGAQHRAEGDQRPRRAAAEPGGAGCRHHPEPIPRPTEGGVVARAEPGQPV 184
               G        AQ R   +Q   R  AE                TE G   R    + +
Sbjct: 1668 LAEG-------TAQQRLAAEQELIRLRAE----------------TEQGEQQRQLLEEEL 1704

Query: 185  HALQGCTWQLSALAEQQRRILQQDWSDLMADPAGVRREYEHFKQHELLSQEQSVNQLEED 244
              LQ    + +A A Q+R+ L+ + + + A+   +       ++    + E+S  +LE +
Sbjct: 1705 ARLQ----REAAAATQKRQELEAELAKVRAEMEVLLASKARAEEESRSTSEKSKQRLEAE 1760

Query: 245  GKRMVELRHPA 255
              R  EL   A
Sbjct: 1761 AGRFRELAEEA 1771


>gi|41322916 plectin 1 isoform 6 [Homo sapiens]
          Length = 4684

 Score = 63.5 bits (153), Expect = 2e-10
 Identities = 72/332 (21%), Positives = 118/332 (35%), Gaps = 50/332 (15%)

Query: 1   MQASADQVERDILETQKRLQQDRLNSEQSQALQHQQETGSSLKEAEVLLKDLFLDVDKAR 60
           +Q  A   E  + +    LQ D       +  Q   E    L +A+ +++ LF DV   +
Sbjct: 538 LQMEAGLCEEQLNQADALLQSDVRLLAAGKVPQRAGEVERDLDKADSMIRLLFNDVQTLK 597

Query: 61  RLKHPQAEETEKDIEQLHERVTQECAEYCALYEKMVLPPRRGIQGRLGTRAGAETEAGLR 120
             +HPQ E+  + + +LHER+     EY    +  V  P   +       A    ++  R
Sbjct: 598 DGRHPQGEQMYRRVYRLHERLVAIRTEYNLRLKAGVAAPATQV-------AQVTLQSVQR 650

Query: 121 RP--------------VWAGH------GGAGGTD---------------------RGAQH 139
           RP               W         G   G D                     R    
Sbjct: 651 RPELEDSTLRYLQDLLAWVEENQHRVDGAEWGVDLPSVEAQLGSHRGLHQSIEEFRAKIE 710

Query: 140 RAEGDQRPRRAAAEPGGAGCRHHPEPIPRPTEGGVVARAEPGQPVHA-LQGCTWQLSALA 198
           RA  D+     A       C    +           AR    + +H+ +   T +L  L 
Sbjct: 711 RARSDEGQLSPATRGAYRDCLGRLDLQYAKLLNSSKARLRSLESLHSFVAAATKELMWLN 770

Query: 199 EQQRRILQQDWSDLMADPAGVRREYEHFKQHELLSQEQSVNQLEEDGKRMVELRHPAVGP 258
           E++   +  DWSD   +    +  Y    + EL  +E+ + +L+  G R++   HPA   
Sbjct: 771 EKEEEEVGFDWSDRNTNMTAKKESYSALMR-ELELKEKKIKELQNAGDRLLREDHPARPT 829

Query: 259 IQAHQEALKMEWQNFLNLCICQETQLQHVEDY 290
           +++ Q AL+ +W   L LC C E  L+    Y
Sbjct: 830 VESFQAALQTQWSWMLQLCCCIEAHLKENAAY 861



 Score = 31.2 bits (69), Expect = 1.2
 Identities = 58/264 (21%), Positives = 102/264 (38%), Gaps = 34/264 (12%)

Query: 2    QASADQVERDILETQKRLQQDRLNSEQSQALQHQQETGSSLKEAEVLLKDLFLDVDKARR 61
            QA A Q ER+  E Q+R+Q++ +  E++ A+  QQ+  S  +E + L +    ++    R
Sbjct: 1518 QAKA-QAEREAKELQQRMQEEVVRREEA-AVDAQQQKRSIQEELQQLRQSSEAEIQAKAR 1575

Query: 62   LKHPQAEETEKDIEQLHERVTQECAEYCALYEKMVLPPRRGIQGRL-GTRAGAETEAGLR 120
                QAE  E+   ++ E +         L  +     R G +G L   RA AE     +
Sbjct: 1576 ----QAEAAERSRLRIEEEI-----RVVRLQLEATERQRGGAEGELQALRARAEEAEAQK 1626

Query: 121  RPVWAGHGGAGGTDRGAQHRAEGDQRPRRAAAEPGGAGCRHHPEPIPRPTEGGVVARAEP 180
            R            +R  +   +  QR R+A  E            +    +    A  E 
Sbjct: 1627 RQ------AQEEAERLRRQVQDESQRKRQAEVE------------LASRVKAEAEAAREK 1668

Query: 181  GQPVHALQGCTWQLSALAEQQRRILQQDWSDLMADPAGVRREYEHFKQHELLSQEQSVNQ 240
             + + AL+    +L   AE+  R L+Q   +            +   + EL S+  S  +
Sbjct: 1669 QRALQALE----ELRLQAEEAERRLRQAEVERARQVQVALETAQRSAEAELQSKRASFAE 1724

Query: 241  LEEDGKRMVELRHPAVGPIQAHQE 264
                 +R ++  H AV  ++   E
Sbjct: 1725 KTAQLERSLQEEHVAVAQLREEAE 1748



 Score = 31.2 bits (69), Expect = 1.2
 Identities = 62/251 (24%), Positives = 95/251 (37%), Gaps = 40/251 (15%)

Query: 7    QVERDILETQKRLQQDRLNSEQSQALQHQQETGSSLKEAEVLLKDLFLDVDKARRLKHPQ 66
            Q+ER + E    + Q  L  E  +  Q Q E   + +EAE  L+   L  ++A RL+  Q
Sbjct: 1728 QLERSLQEEHVAVAQ--LREEAERRAQQQAEAERAREEAERELERWQLKANEALRLR-LQ 1784

Query: 67   AEET--EKDIEQLHERVTQECAEYCALYEKMVLPPRRGIQGRLGTRAGAETEAGLRRPVW 124
            AEE   +K + Q      +E AE  A         RRG       R     E  L +   
Sbjct: 1785 AEEVAQQKSLAQAEAEKQKEEAEREA--------RRRGKAEEQAVRQRELAEQELEKQRQ 1836

Query: 125  AGHGGAGGTDRGAQHRAEGDQRPRRAAAEPGGAGCRHHPEPIPRPTEGGVVARAEPGQPV 184
               G        AQ R   +Q   R  AE                TE G   R    + +
Sbjct: 1837 LAEG-------TAQQRLAAEQELIRLRAE----------------TEQGEQQRQLLEEEL 1873

Query: 185  HALQGCTWQLSALAEQQRRILQQDWSDLMADPAGVRREYEHFKQHELLSQEQSVNQLEED 244
              LQ    + +A A Q+R+ L+ + + + A+   +       ++    + E+S  +LE +
Sbjct: 1874 ARLQ----REAAAATQKRQELEAELAKVRAEMEVLLASKARAEEESRSTSEKSKQRLEAE 1929

Query: 245  GKRMVELRHPA 255
              R  EL   A
Sbjct: 1930 AGRFRELAEEA 1940


>gi|41322908 plectin 1 isoform 3 [Homo sapiens]
          Length = 4525

 Score = 63.5 bits (153), Expect = 2e-10
 Identities = 72/332 (21%), Positives = 118/332 (35%), Gaps = 50/332 (15%)

Query: 1   MQASADQVERDILETQKRLQQDRLNSEQSQALQHQQETGSSLKEAEVLLKDLFLDVDKAR 60
           +Q  A   E  + +    LQ D       +  Q   E    L +A+ +++ LF DV   +
Sbjct: 379 LQMEAGLCEEQLNQADALLQSDVRLLAAGKVPQRAGEVERDLDKADSMIRLLFNDVQTLK 438

Query: 61  RLKHPQAEETEKDIEQLHERVTQECAEYCALYEKMVLPPRRGIQGRLGTRAGAETEAGLR 120
             +HPQ E+  + + +LHER+     EY    +  V  P   +       A    ++  R
Sbjct: 439 DGRHPQGEQMYRRVYRLHERLVAIRTEYNLRLKAGVAAPATQV-------AQVTLQSVQR 491

Query: 121 RP--------------VWAGH------GGAGGTD---------------------RGAQH 139
           RP               W         G   G D                     R    
Sbjct: 492 RPELEDSTLRYLQDLLAWVEENQHRVDGAEWGVDLPSVEAQLGSHRGLHQSIEEFRAKIE 551

Query: 140 RAEGDQRPRRAAAEPGGAGCRHHPEPIPRPTEGGVVARAEPGQPVHA-LQGCTWQLSALA 198
           RA  D+     A       C    +           AR    + +H+ +   T +L  L 
Sbjct: 552 RARSDEGQLSPATRGAYRDCLGRLDLQYAKLLNSSKARLRSLESLHSFVAAATKELMWLN 611

Query: 199 EQQRRILQQDWSDLMADPAGVRREYEHFKQHELLSQEQSVNQLEEDGKRMVELRHPAVGP 258
           E++   +  DWSD   +    +  Y    + EL  +E+ + +L+  G R++   HPA   
Sbjct: 612 EKEEEEVGFDWSDRNTNMTAKKESYSALMR-ELELKEKKIKELQNAGDRLLREDHPARPT 670

Query: 259 IQAHQEALKMEWQNFLNLCICQETQLQHVEDY 290
           +++ Q AL+ +W   L LC C E  L+    Y
Sbjct: 671 VESFQAALQTQWSWMLQLCCCIEAHLKENAAY 702



 Score = 31.2 bits (69), Expect = 1.2
 Identities = 58/264 (21%), Positives = 102/264 (38%), Gaps = 34/264 (12%)

Query: 2    QASADQVERDILETQKRLQQDRLNSEQSQALQHQQETGSSLKEAEVLLKDLFLDVDKARR 61
            QA A Q ER+  E Q+R+Q++ +  E++ A+  QQ+  S  +E + L +    ++    R
Sbjct: 1359 QAKA-QAEREAKELQQRMQEEVVRREEA-AVDAQQQKRSIQEELQQLRQSSEAEIQAKAR 1416

Query: 62   LKHPQAEETEKDIEQLHERVTQECAEYCALYEKMVLPPRRGIQGRL-GTRAGAETEAGLR 120
                QAE  E+   ++ E +         L  +     R G +G L   RA AE     +
Sbjct: 1417 ----QAEAAERSRLRIEEEI-----RVVRLQLEATERQRGGAEGELQALRARAEEAEAQK 1467

Query: 121  RPVWAGHGGAGGTDRGAQHRAEGDQRPRRAAAEPGGAGCRHHPEPIPRPTEGGVVARAEP 180
            R            +R  +   +  QR R+A  E            +    +    A  E 
Sbjct: 1468 RQ------AQEEAERLRRQVQDESQRKRQAEVE------------LASRVKAEAEAAREK 1509

Query: 181  GQPVHALQGCTWQLSALAEQQRRILQQDWSDLMADPAGVRREYEHFKQHELLSQEQSVNQ 240
             + + AL+    +L   AE+  R L+Q   +            +   + EL S+  S  +
Sbjct: 1510 QRALQALE----ELRLQAEEAERRLRQAEVERARQVQVALETAQRSAEAELQSKRASFAE 1565

Query: 241  LEEDGKRMVELRHPAVGPIQAHQE 264
                 +R ++  H AV  ++   E
Sbjct: 1566 KTAQLERSLQEEHVAVAQLREEAE 1589



 Score = 31.2 bits (69), Expect = 1.2
 Identities = 62/251 (24%), Positives = 95/251 (37%), Gaps = 40/251 (15%)

Query: 7    QVERDILETQKRLQQDRLNSEQSQALQHQQETGSSLKEAEVLLKDLFLDVDKARRLKHPQ 66
            Q+ER + E    + Q  L  E  +  Q Q E   + +EAE  L+   L  ++A RL+  Q
Sbjct: 1569 QLERSLQEEHVAVAQ--LREEAERRAQQQAEAERAREEAERELERWQLKANEALRLR-LQ 1625

Query: 67   AEET--EKDIEQLHERVTQECAEYCALYEKMVLPPRRGIQGRLGTRAGAETEAGLRRPVW 124
            AEE   +K + Q      +E AE  A         RRG       R     E  L +   
Sbjct: 1626 AEEVAQQKSLAQAEAEKQKEEAEREA--------RRRGKAEEQAVRQRELAEQELEKQRQ 1677

Query: 125  AGHGGAGGTDRGAQHRAEGDQRPRRAAAEPGGAGCRHHPEPIPRPTEGGVVARAEPGQPV 184
               G        AQ R   +Q   R  AE                TE G   R    + +
Sbjct: 1678 LAEG-------TAQQRLAAEQELIRLRAE----------------TEQGEQQRQLLEEEL 1714

Query: 185  HALQGCTWQLSALAEQQRRILQQDWSDLMADPAGVRREYEHFKQHELLSQEQSVNQLEED 244
              LQ    + +A A Q+R+ L+ + + + A+   +       ++    + E+S  +LE +
Sbjct: 1715 ARLQ----REAAAATQKRQELEAELAKVRAEMEVLLASKARAEEESRSTSEKSKQRLEAE 1770

Query: 245  GKRMVELRHPA 255
              R  EL   A
Sbjct: 1771 AGRFRELAEEA 1781


>gi|41322912 plectin 1 isoform 2 [Homo sapiens]
          Length = 4533

 Score = 63.5 bits (153), Expect = 2e-10
 Identities = 72/332 (21%), Positives = 118/332 (35%), Gaps = 50/332 (15%)

Query: 1   MQASADQVERDILETQKRLQQDRLNSEQSQALQHQQETGSSLKEAEVLLKDLFLDVDKAR 60
           +Q  A   E  + +    LQ D       +  Q   E    L +A+ +++ LF DV   +
Sbjct: 387 LQMEAGLCEEQLNQADALLQSDVRLLAAGKVPQRAGEVERDLDKADSMIRLLFNDVQTLK 446

Query: 61  RLKHPQAEETEKDIEQLHERVTQECAEYCALYEKMVLPPRRGIQGRLGTRAGAETEAGLR 120
             +HPQ E+  + + +LHER+     EY    +  V  P   +       A    ++  R
Sbjct: 447 DGRHPQGEQMYRRVYRLHERLVAIRTEYNLRLKAGVAAPATQV-------AQVTLQSVQR 499

Query: 121 RP--------------VWAGH------GGAGGTD---------------------RGAQH 139
           RP               W         G   G D                     R    
Sbjct: 500 RPELEDSTLRYLQDLLAWVEENQHRVDGAEWGVDLPSVEAQLGSHRGLHQSIEEFRAKIE 559

Query: 140 RAEGDQRPRRAAAEPGGAGCRHHPEPIPRPTEGGVVARAEPGQPVHA-LQGCTWQLSALA 198
           RA  D+     A       C    +           AR    + +H+ +   T +L  L 
Sbjct: 560 RARSDEGQLSPATRGAYRDCLGRLDLQYAKLLNSSKARLRSLESLHSFVAAATKELMWLN 619

Query: 199 EQQRRILQQDWSDLMADPAGVRREYEHFKQHELLSQEQSVNQLEEDGKRMVELRHPAVGP 258
           E++   +  DWSD   +    +  Y    + EL  +E+ + +L+  G R++   HPA   
Sbjct: 620 EKEEEEVGFDWSDRNTNMTAKKESYSALMR-ELELKEKKIKELQNAGDRLLREDHPARPT 678

Query: 259 IQAHQEALKMEWQNFLNLCICQETQLQHVEDY 290
           +++ Q AL+ +W   L LC C E  L+    Y
Sbjct: 679 VESFQAALQTQWSWMLQLCCCIEAHLKENAAY 710



 Score = 31.2 bits (69), Expect = 1.2
 Identities = 58/264 (21%), Positives = 102/264 (38%), Gaps = 34/264 (12%)

Query: 2    QASADQVERDILETQKRLQQDRLNSEQSQALQHQQETGSSLKEAEVLLKDLFLDVDKARR 61
            QA A Q ER+  E Q+R+Q++ +  E++ A+  QQ+  S  +E + L +    ++    R
Sbjct: 1367 QAKA-QAEREAKELQQRMQEEVVRREEA-AVDAQQQKRSIQEELQQLRQSSEAEIQAKAR 1424

Query: 62   LKHPQAEETEKDIEQLHERVTQECAEYCALYEKMVLPPRRGIQGRL-GTRAGAETEAGLR 120
                QAE  E+   ++ E +         L  +     R G +G L   RA AE     +
Sbjct: 1425 ----QAEAAERSRLRIEEEI-----RVVRLQLEATERQRGGAEGELQALRARAEEAEAQK 1475

Query: 121  RPVWAGHGGAGGTDRGAQHRAEGDQRPRRAAAEPGGAGCRHHPEPIPRPTEGGVVARAEP 180
            R            +R  +   +  QR R+A  E            +    +    A  E 
Sbjct: 1476 RQ------AQEEAERLRRQVQDESQRKRQAEVE------------LASRVKAEAEAAREK 1517

Query: 181  GQPVHALQGCTWQLSALAEQQRRILQQDWSDLMADPAGVRREYEHFKQHELLSQEQSVNQ 240
             + + AL+    +L   AE+  R L+Q   +            +   + EL S+  S  +
Sbjct: 1518 QRALQALE----ELRLQAEEAERRLRQAEVERARQVQVALETAQRSAEAELQSKRASFAE 1573

Query: 241  LEEDGKRMVELRHPAVGPIQAHQE 264
                 +R ++  H AV  ++   E
Sbjct: 1574 KTAQLERSLQEEHVAVAQLREEAE 1597



 Score = 31.2 bits (69), Expect = 1.2
 Identities = 62/251 (24%), Positives = 95/251 (37%), Gaps = 40/251 (15%)

Query: 7    QVERDILETQKRLQQDRLNSEQSQALQHQQETGSSLKEAEVLLKDLFLDVDKARRLKHPQ 66
            Q+ER + E    + Q  L  E  +  Q Q E   + +EAE  L+   L  ++A RL+  Q
Sbjct: 1577 QLERSLQEEHVAVAQ--LREEAERRAQQQAEAERAREEAERELERWQLKANEALRLR-LQ 1633

Query: 67   AEET--EKDIEQLHERVTQECAEYCALYEKMVLPPRRGIQGRLGTRAGAETEAGLRRPVW 124
            AEE   +K + Q      +E AE  A         RRG       R     E  L +   
Sbjct: 1634 AEEVAQQKSLAQAEAEKQKEEAEREA--------RRRGKAEEQAVRQRELAEQELEKQRQ 1685

Query: 125  AGHGGAGGTDRGAQHRAEGDQRPRRAAAEPGGAGCRHHPEPIPRPTEGGVVARAEPGQPV 184
               G        AQ R   +Q   R  AE                TE G   R    + +
Sbjct: 1686 LAEG-------TAQQRLAAEQELIRLRAE----------------TEQGEQQRQLLEEEL 1722

Query: 185  HALQGCTWQLSALAEQQRRILQQDWSDLMADPAGVRREYEHFKQHELLSQEQSVNQLEED 244
              LQ    + +A A Q+R+ L+ + + + A+   +       ++    + E+S  +LE +
Sbjct: 1723 ARLQ----REAAAATQKRQELEAELAKVRAEMEVLLASKARAEEESRSTSEKSKQRLEAE 1778

Query: 245  GKRMVELRHPA 255
              R  EL   A
Sbjct: 1779 AGRFRELAEEA 1789


>gi|47607492 plectin 1 isoform 1 [Homo sapiens]
          Length = 4574

 Score = 63.5 bits (153), Expect = 2e-10
 Identities = 72/332 (21%), Positives = 118/332 (35%), Gaps = 50/332 (15%)

Query: 1   MQASADQVERDILETQKRLQQDRLNSEQSQALQHQQETGSSLKEAEVLLKDLFLDVDKAR 60
           +Q  A   E  + +    LQ D       +  Q   E    L +A+ +++ LF DV   +
Sbjct: 428 LQMEAGLCEEQLNQADALLQSDVRLLAAGKVPQRAGEVERDLDKADSMIRLLFNDVQTLK 487

Query: 61  RLKHPQAEETEKDIEQLHERVTQECAEYCALYEKMVLPPRRGIQGRLGTRAGAETEAGLR 120
             +HPQ E+  + + +LHER+     EY    +  V  P   +       A    ++  R
Sbjct: 488 DGRHPQGEQMYRRVYRLHERLVAIRTEYNLRLKAGVAAPATQV-------AQVTLQSVQR 540

Query: 121 RP--------------VWAGH------GGAGGTD---------------------RGAQH 139
           RP               W         G   G D                     R    
Sbjct: 541 RPELEDSTLRYLQDLLAWVEENQHRVDGAEWGVDLPSVEAQLGSHRGLHQSIEEFRAKIE 600

Query: 140 RAEGDQRPRRAAAEPGGAGCRHHPEPIPRPTEGGVVARAEPGQPVHA-LQGCTWQLSALA 198
           RA  D+     A       C    +           AR    + +H+ +   T +L  L 
Sbjct: 601 RARSDEGQLSPATRGAYRDCLGRLDLQYAKLLNSSKARLRSLESLHSFVAAATKELMWLN 660

Query: 199 EQQRRILQQDWSDLMADPAGVRREYEHFKQHELLSQEQSVNQLEEDGKRMVELRHPAVGP 258
           E++   +  DWSD   +    +  Y    + EL  +E+ + +L+  G R++   HPA   
Sbjct: 661 EKEEEEVGFDWSDRNTNMTAKKESYSALMR-ELELKEKKIKELQNAGDRLLREDHPARPT 719

Query: 259 IQAHQEALKMEWQNFLNLCICQETQLQHVEDY 290
           +++ Q AL+ +W   L LC C E  L+    Y
Sbjct: 720 VESFQAALQTQWSWMLQLCCCIEAHLKENAAY 751



 Score = 31.2 bits (69), Expect = 1.2
 Identities = 58/264 (21%), Positives = 102/264 (38%), Gaps = 34/264 (12%)

Query: 2    QASADQVERDILETQKRLQQDRLNSEQSQALQHQQETGSSLKEAEVLLKDLFLDVDKARR 61
            QA A Q ER+  E Q+R+Q++ +  E++ A+  QQ+  S  +E + L +    ++    R
Sbjct: 1408 QAKA-QAEREAKELQQRMQEEVVRREEA-AVDAQQQKRSIQEELQQLRQSSEAEIQAKAR 1465

Query: 62   LKHPQAEETEKDIEQLHERVTQECAEYCALYEKMVLPPRRGIQGRL-GTRAGAETEAGLR 120
                QAE  E+   ++ E +         L  +     R G +G L   RA AE     +
Sbjct: 1466 ----QAEAAERSRLRIEEEI-----RVVRLQLEATERQRGGAEGELQALRARAEEAEAQK 1516

Query: 121  RPVWAGHGGAGGTDRGAQHRAEGDQRPRRAAAEPGGAGCRHHPEPIPRPTEGGVVARAEP 180
            R            +R  +   +  QR R+A  E            +    +    A  E 
Sbjct: 1517 RQ------AQEEAERLRRQVQDESQRKRQAEVE------------LASRVKAEAEAAREK 1558

Query: 181  GQPVHALQGCTWQLSALAEQQRRILQQDWSDLMADPAGVRREYEHFKQHELLSQEQSVNQ 240
             + + AL+    +L   AE+  R L+Q   +            +   + EL S+  S  +
Sbjct: 1559 QRALQALE----ELRLQAEEAERRLRQAEVERARQVQVALETAQRSAEAELQSKRASFAE 1614

Query: 241  LEEDGKRMVELRHPAVGPIQAHQE 264
                 +R ++  H AV  ++   E
Sbjct: 1615 KTAQLERSLQEEHVAVAQLREEAE 1638



 Score = 31.2 bits (69), Expect = 1.2
 Identities = 62/251 (24%), Positives = 95/251 (37%), Gaps = 40/251 (15%)

Query: 7    QVERDILETQKRLQQDRLNSEQSQALQHQQETGSSLKEAEVLLKDLFLDVDKARRLKHPQ 66
            Q+ER + E    + Q  L  E  +  Q Q E   + +EAE  L+   L  ++A RL+  Q
Sbjct: 1618 QLERSLQEEHVAVAQ--LREEAERRAQQQAEAERAREEAERELERWQLKANEALRLR-LQ 1674

Query: 67   AEET--EKDIEQLHERVTQECAEYCALYEKMVLPPRRGIQGRLGTRAGAETEAGLRRPVW 124
            AEE   +K + Q      +E AE  A         RRG       R     E  L +   
Sbjct: 1675 AEEVAQQKSLAQAEAEKQKEEAEREA--------RRRGKAEEQAVRQRELAEQELEKQRQ 1726

Query: 125  AGHGGAGGTDRGAQHRAEGDQRPRRAAAEPGGAGCRHHPEPIPRPTEGGVVARAEPGQPV 184
               G        AQ R   +Q   R  AE                TE G   R    + +
Sbjct: 1727 LAEG-------TAQQRLAAEQELIRLRAE----------------TEQGEQQRQLLEEEL 1763

Query: 185  HALQGCTWQLSALAEQQRRILQQDWSDLMADPAGVRREYEHFKQHELLSQEQSVNQLEED 244
              LQ    + +A A Q+R+ L+ + + + A+   +       ++    + E+S  +LE +
Sbjct: 1764 ARLQ----REAAAATQKRQELEAELAKVRAEMEVLLASKARAEEESRSTSEKSKQRLEAE 1819

Query: 245  GKRMVELRHPA 255
              R  EL   A
Sbjct: 1820 AGRFRELAEEA 1830


>gi|169218211 PREDICTED: similar to plectin 1, partial [Homo
           sapiens]
          Length = 1369

 Score = 62.8 bits (151), Expect = 4e-10
 Identities = 73/332 (21%), Positives = 120/332 (36%), Gaps = 50/332 (15%)

Query: 1   MQASADQVERDILETQKRLQQDRLNSEQSQALQHQQETGSSLKEAEVLLKDLFLDVDKAR 60
           +Q  A   E  + +    LQ D       +  Q   E    L +A+ +++ LF DV   +
Sbjct: 534 LQMEAGLCEEQLHQADALLQSDIRLLAAGKVPQRAGEVERDLDKADSMIRLLFNDVQTLK 593

Query: 61  RLKHPQAEETEKDIEQLHERVTQECAEYCALYEKMVLPPRRGIQGRLGTRAGAETEAGLR 120
             +HPQ E+  + + +LHER+     EY    +  V  P   +       A    ++  R
Sbjct: 594 DGRHPQGEQMYRRVYRLHERLVAIRTEYNLRLKAGVAAPATQV-------AQVTLQSVQR 646

Query: 121 RP--------------VWAGH------GGAGGTDRGAQHRAEGDQRPRRAAAEPGGAG-- 158
           RP               W         G   G D  +     G  R    + E   A   
Sbjct: 647 RPELEDSTLRYLQDLLAWVEENQHRVDGAEWGVDLPSVEAQLGSHRGLHQSIEEFQAKIE 706

Query: 159 -CRHHPEPIPRPTEGGV------------------VARAEPGQPVHA-LQGCTWQLSALA 198
             R     +   T G                     AR    + +H+ +   T +L  L 
Sbjct: 707 RARSDEGQLSPATRGAYRDCLGRLDLQYAKLLNSSKARLRSLESLHSFVAAATKELMWLN 766

Query: 199 EQQRRILQQDWSDLMADPAGVRREYEHFKQHELLSQEQSVNQLEEDGKRMVELRHPAVGP 258
           E++   +  DWSD   +    +  Y    + EL  +E+ + +L+  G R++   HPA   
Sbjct: 767 EKEEEEVGFDWSDRNTNMTAKKESYSALMR-ELELKEKKIKELQNAGDRLLREDHPARPT 825

Query: 259 IQAHQEALKMEWQNFLNLCICQETQLQHVEDY 290
           +++ Q AL+ +W   L LC C E  L+    Y
Sbjct: 826 VESFQAALQTQWSWMLQLCCCIEAHLKENAAY 857


>gi|221316624 dystonin isoform 4 [Homo sapiens]
          Length = 5526

 Score = 47.4 bits (111), Expect = 2e-05
 Identities = 27/99 (27%), Positives = 55/99 (55%), Gaps = 4/99 (4%)

Query: 191 TWQLSALAEQQRRILQQDWSDLMADPAGVRREYEHFKQHELLSQEQSVNQLEEDGKRMVE 250
           T +L  L E++   +  DWS+   + A  +++Y      EL  +E+++  ++E  ++++ 
Sbjct: 738 TNELIWLNEKEEEEVAYDWSERNTNIAR-KKDYHAELMRELDQKEENIKSVQEIAEQLLL 796

Query: 251 LRHPAVGPIQAHQEALKMEWQNFLNLCICQETQLQHVED 289
             HPA   I+A++ A++ +W   L LC C E   QH+++
Sbjct: 797 ENHPARLTIEAYRAAMQTQWSWILQLCQCVE---QHIKE 832



 Score = 32.0 bits (71), Expect = 0.69
 Identities = 24/101 (23%), Positives = 46/101 (45%), Gaps = 7/101 (6%)

Query: 1   MQASADQVERDILETQKRL-------QQDRLNSEQSQALQHQQETGSSLKEAEVLLKDLF 53
           +Q  A++V+RD +  + +L       Q D    E     Q++ E    + E E LL+   
Sbjct: 415 LQQIANRVQRDSVICEDKLILAGNALQSDSKRLESGVQFQNEAEIAGYILECENLLRQHV 474

Query: 54  LDVDKARRLKHPQAEETEKDIEQLHERVTQECAEYCALYEK 94
           +DV      K+ QA++  + + +L + +     E  ++Y K
Sbjct: 475 IDVQILIDGKYYQADQLVQRVAKLRDEIMALRNECSSVYSK 515


>gi|221316622 dystonin isoform 3 [Homo sapiens]
          Length = 5537

 Score = 47.4 bits (111), Expect = 2e-05
 Identities = 27/99 (27%), Positives = 55/99 (55%), Gaps = 4/99 (4%)

Query: 191 TWQLSALAEQQRRILQQDWSDLMADPAGVRREYEHFKQHELLSQEQSVNQLEEDGKRMVE 250
           T +L  L E++   +  DWS+   + A  +++Y      EL  +E+++  ++E  ++++ 
Sbjct: 749 TNELIWLNEKEEEEVAYDWSERNTNIAR-KKDYHAELMRELDQKEENIKSVQEIAEQLLL 807

Query: 251 LRHPAVGPIQAHQEALKMEWQNFLNLCICQETQLQHVED 289
             HPA   I+A++ A++ +W   L LC C E   QH+++
Sbjct: 808 ENHPARLTIEAYRAAMQTQWSWILQLCQCVE---QHIKE 843



 Score = 32.0 bits (71), Expect = 0.69
 Identities = 24/101 (23%), Positives = 46/101 (45%), Gaps = 7/101 (6%)

Query: 1   MQASADQVERDILETQKRL-------QQDRLNSEQSQALQHQQETGSSLKEAEVLLKDLF 53
           +Q  A++V+RD +  + +L       Q D    E     Q++ E    + E E LL+   
Sbjct: 426 LQQIANRVQRDSVICEDKLILAGNALQSDSKRLESGVQFQNEAEIAGYILECENLLRQHV 485

Query: 54  LDVDKARRLKHPQAEETEKDIEQLHERVTQECAEYCALYEK 94
           +DV      K+ QA++  + + +L + +     E  ++Y K
Sbjct: 486 IDVQILIDGKYYQADQLVQRVAKLRDEIMALRNECSSVYSK 526


>gi|221316618 dystonin isoform 2 [Homo sapiens]
          Length = 5675

 Score = 47.4 bits (111), Expect = 2e-05
 Identities = 27/99 (27%), Positives = 55/99 (55%), Gaps = 4/99 (4%)

Query: 191 TWQLSALAEQQRRILQQDWSDLMADPAGVRREYEHFKQHELLSQEQSVNQLEEDGKRMVE 250
           T +L  L E++   +  DWS+   + A  +++Y      EL  +E+++  ++E  ++++ 
Sbjct: 887 TNELIWLNEKEEEEVAYDWSERNTNIAR-KKDYHAELMRELDQKEENIKSVQEIAEQLLL 945

Query: 251 LRHPAVGPIQAHQEALKMEWQNFLNLCICQETQLQHVED 289
             HPA   I+A++ A++ +W   L LC C E   QH+++
Sbjct: 946 ENHPARLTIEAYRAAMQTQWSWILQLCQCVE---QHIKE 981



 Score = 32.0 bits (71), Expect = 0.69
 Identities = 24/101 (23%), Positives = 46/101 (45%), Gaps = 7/101 (6%)

Query: 1   MQASADQVERDILETQKRL-------QQDRLNSEQSQALQHQQETGSSLKEAEVLLKDLF 53
           +Q  A++V+RD +  + +L       Q D    E     Q++ E    + E E LL+   
Sbjct: 564 LQQIANRVQRDSVICEDKLILAGNALQSDSKRLESGVQFQNEAEIAGYILECENLLRQHV 623

Query: 54  LDVDKARRLKHPQAEETEKDIEQLHERVTQECAEYCALYEK 94
           +DV      K+ QA++  + + +L + +     E  ++Y K
Sbjct: 624 IDVQILIDGKYYQADQLVQRVAKLRDEIMALRNECSSVYSK 664


>gi|34577047 dystonin isoform 1 [Homo sapiens]
          Length = 5497

 Score = 47.4 bits (111), Expect = 2e-05
 Identities = 27/99 (27%), Positives = 55/99 (55%), Gaps = 4/99 (4%)

Query: 191 TWQLSALAEQQRRILQQDWSDLMADPAGVRREYEHFKQHELLSQEQSVNQLEEDGKRMVE 250
           T +L  L E++   +  DWS+   + A  +++Y      EL  +E+++  ++E  ++++ 
Sbjct: 709 TNELIWLNEKEEEEVAYDWSERNTNIAR-KKDYHAELMRELDQKEENIKSVQEIAEQLLL 767

Query: 251 LRHPAVGPIQAHQEALKMEWQNFLNLCICQETQLQHVED 289
             HPA   I+A++ A++ +W   L LC C E   QH+++
Sbjct: 768 ENHPARLTIEAYRAAMQTQWSWILQLCQCVE---QHIKE 803



 Score = 32.0 bits (71), Expect = 0.69
 Identities = 24/101 (23%), Positives = 46/101 (45%), Gaps = 7/101 (6%)

Query: 1   MQASADQVERDILETQKRL-------QQDRLNSEQSQALQHQQETGSSLKEAEVLLKDLF 53
           +Q  A++V+RD +  + +L       Q D    E     Q++ E    + E E LL+   
Sbjct: 386 LQQIANRVQRDSVICEDKLILAGNALQSDSKRLESGVQFQNEAEIAGYILECENLLRQHV 445

Query: 54  LDVDKARRLKHPQAEETEKDIEQLHERVTQECAEYCALYEK 94
           +DV      K+ QA++  + + +L + +     E  ++Y K
Sbjct: 446 IDVQILIDGKYYQADQLVQRVAKLRDEIMALRNECSSVYSK 486


>gi|20357504 dystonin isoform 1eB precursor [Homo sapiens]
          Length = 3062

 Score = 47.4 bits (111), Expect = 2e-05
 Identities = 27/99 (27%), Positives = 55/99 (55%), Gaps = 4/99 (4%)

Query: 191 TWQLSALAEQQRRILQQDWSDLMADPAGVRREYEHFKQHELLSQEQSVNQLEEDGKRMVE 250
           T +L  L E++   +  DWS+   + A  +++Y      EL  +E+++  ++E  ++++ 
Sbjct: 383 TNELIWLNEKEEEEVAYDWSERNTNIAR-KKDYHAELMRELDQKEENIKSVQEIAEQLLL 441

Query: 251 LRHPAVGPIQAHQEALKMEWQNFLNLCICQETQLQHVED 289
             HPA   I+A++ A++ +W   L LC C E   QH+++
Sbjct: 442 ENHPARLTIEAYRAAMQTQWSWILQLCQCVE---QHIKE 477



 Score = 32.0 bits (71), Expect = 0.69
 Identities = 24/101 (23%), Positives = 46/101 (45%), Gaps = 7/101 (6%)

Query: 1   MQASADQVERDILETQKRL-------QQDRLNSEQSQALQHQQETGSSLKEAEVLLKDLF 53
           +Q  A++V+RD +  + +L       Q D    E     Q++ E    + E E LL+   
Sbjct: 60  LQQIANRVQRDSVICEDKLILAGNALQSDSKRLESGVQFQNEAEIAGYILECENLLRQHV 119

Query: 54  LDVDKARRLKHPQAEETEKDIEQLHERVTQECAEYCALYEK 94
           +DV      K+ QA++  + + +L + +     E  ++Y K
Sbjct: 120 IDVQILIDGKYYQADQLVQRVAKLRDEIMALRNECSSVYSK 160


>gi|34577049 dystonin isoform 1eA precursor [Homo sapiens]
          Length = 5171

 Score = 47.4 bits (111), Expect = 2e-05
 Identities = 27/99 (27%), Positives = 55/99 (55%), Gaps = 4/99 (4%)

Query: 191 TWQLSALAEQQRRILQQDWSDLMADPAGVRREYEHFKQHELLSQEQSVNQLEEDGKRMVE 250
           T +L  L E++   +  DWS+   + A  +++Y      EL  +E+++  ++E  ++++ 
Sbjct: 383 TNELIWLNEKEEEEVAYDWSERNTNIAR-KKDYHAELMRELDQKEENIKSVQEIAEQLLL 441

Query: 251 LRHPAVGPIQAHQEALKMEWQNFLNLCICQETQLQHVED 289
             HPA   I+A++ A++ +W   L LC C E   QH+++
Sbjct: 442 ENHPARLTIEAYRAAMQTQWSWILQLCQCVE---QHIKE 477



 Score = 32.0 bits (71), Expect = 0.69
 Identities = 24/101 (23%), Positives = 46/101 (45%), Gaps = 7/101 (6%)

Query: 1   MQASADQVERDILETQKRL-------QQDRLNSEQSQALQHQQETGSSLKEAEVLLKDLF 53
           +Q  A++V+RD +  + +L       Q D    E     Q++ E    + E E LL+   
Sbjct: 60  LQQIANRVQRDSVICEDKLILAGNALQSDSKRLESGVQFQNEAEIAGYILECENLLRQHV 119

Query: 54  LDVDKARRLKHPQAEETEKDIEQLHERVTQECAEYCALYEK 94
           +DV      K+ QA++  + + +L + +     E  ++Y K
Sbjct: 120 IDVQILIDGKYYQADQLVQRVAKLRDEIMALRNECSSVYSK 160


>gi|4502443 dystonin isoform 1e precursor [Homo sapiens]
          Length = 2649

 Score = 47.4 bits (111), Expect = 2e-05
 Identities = 27/99 (27%), Positives = 55/99 (55%), Gaps = 4/99 (4%)

Query: 191 TWQLSALAEQQRRILQQDWSDLMADPAGVRREYEHFKQHELLSQEQSVNQLEEDGKRMVE 250
           T +L  L E++   +  DWS+   + A  +++Y      EL  +E+++  ++E  ++++ 
Sbjct: 383 TNELIWLNEKEEEEVAYDWSERNTNIAR-KKDYHAELMRELDQKEENIKSVQEIAEQLLL 441

Query: 251 LRHPAVGPIQAHQEALKMEWQNFLNLCICQETQLQHVED 289
             HPA   I+A++ A++ +W   L LC C E   QH+++
Sbjct: 442 ENHPARLTIEAYRAAMQTQWSWILQLCQCVE---QHIKE 477



 Score = 32.0 bits (71), Expect = 0.69
 Identities = 24/101 (23%), Positives = 46/101 (45%), Gaps = 7/101 (6%)

Query: 1   MQASADQVERDILETQKRL-------QQDRLNSEQSQALQHQQETGSSLKEAEVLLKDLF 53
           +Q  A++V+RD +  + +L       Q D    E     Q++ E    + E E LL+   
Sbjct: 60  LQQIANRVQRDSVICEDKLILAGNALQSDSKRLESGVQFQNEAEIAGYILECENLLRQHV 119

Query: 54  LDVDKARRLKHPQAEETEKDIEQLHERVTQECAEYCALYEK 94
           +DV      K+ QA++  + + +L + +     E  ++Y K
Sbjct: 120 IDVQILIDGKYYQADQLVQRVAKLRDEIMALRNECSSVYSK 160


>gi|58530842 desmoplakin isoform II [Homo sapiens]
          Length = 2272

 Score = 43.5 bits (101), Expect = 2e-04
 Identities = 24/104 (23%), Positives = 54/104 (51%), Gaps = 1/104 (0%)

Query: 187 LQGCTWQLSALAEQQRRILQQDWSDLMADPAGVRREYEHFKQHELLSQEQSVNQLEEDGK 246
           +Q  + ++  + + +   L  DWSD   + A  ++E    +  +L  +E+ +N+L+++  
Sbjct: 276 IQATSREIMWINDCEEEELLYDWSDKNTNIAQ-KQEAFSIRMSQLEVKEKELNKLKQESD 334

Query: 247 RMVELRHPAVGPIQAHQEALKMEWQNFLNLCICQETQLQHVEDY 290
           ++V  +HPA   I+A+ + L+ +W   L +  C +  L+    Y
Sbjct: 335 QLVLNQHPASDKIEAYMDTLQTQWSWILQITKCIDVHLKENAAY 378


>gi|58530840 desmoplakin isoform I [Homo sapiens]
          Length = 2871

 Score = 43.5 bits (101), Expect = 2e-04
 Identities = 24/104 (23%), Positives = 54/104 (51%), Gaps = 1/104 (0%)

Query: 187 LQGCTWQLSALAEQQRRILQQDWSDLMADPAGVRREYEHFKQHELLSQEQSVNQLEEDGK 246
           +Q  + ++  + + +   L  DWSD   + A  ++E    +  +L  +E+ +N+L+++  
Sbjct: 276 IQATSREIMWINDCEEEELLYDWSDKNTNIAQ-KQEAFSIRMSQLEVKEKELNKLKQESD 334

Query: 247 RMVELRHPAVGPIQAHQEALKMEWQNFLNLCICQETQLQHVEDY 290
           ++V  +HPA   I+A+ + L+ +W   L +  C +  L+    Y
Sbjct: 335 QLVLNQHPASDKIEAYMDTLQTQWSWILQITKCIDVHLKENAAY 378


>gi|33188445 microfilament and actin filament cross-linker protein
           isoform a [Homo sapiens]
          Length = 5430

 Score = 40.8 bits (94), Expect = 0.001
 Identities = 28/100 (28%), Positives = 50/100 (50%), Gaps = 6/100 (6%)

Query: 191 TWQLSALAEQQRRILQQDWSDLMADPAGVRREYEHFKQHELLSQEQSVNQLEEDGKRMVE 250
           T +L  L E++   L  DWSD  ++ +  R  +        L ++Q V +  +D   ++ 
Sbjct: 690 TAELIWLNEKEEEELAYDWSDNNSNISAKRNYFSELTME--LEEKQDVFRSLQDTAELLS 747

Query: 251 LR-HPAVGPIQAHQEALKMEWQNFLNLCICQETQLQHVED 289
           L  HPA   ++A+  A++ + Q    LC+C E   QHV++
Sbjct: 748 LENHPAKQTVEAYSAAVQSQLQWMKQLCLCVE---QHVKE 784


>gi|56549694 enabled homolog isoform a [Homo sapiens]
          Length = 591

 Score = 38.9 bits (89), Expect = 0.006
 Identities = 41/179 (22%), Positives = 77/179 (43%), Gaps = 11/179 (6%)

Query: 6   DQVERDILETQKRLQQDRLNSEQSQALQHQQETGSSLKEAEVLLKDLFLDVDKARRLKHP 65
           +++ER+ LE ++RL+++RL  EQ +  + ++E    L+  E L +   L  ++  RL   
Sbjct: 169 ERLERERLE-RERLERERLEQEQLERERQERERQERLERQERLERQERL--ERQERLDRE 225

Query: 66  QAEETEKDIEQLHERVTQECAEYCALYEKMVLPPRRGIQGRLGTR-AGAETEAGLRRPVW 124
           + E  E++  +  ER  QE        E+     R  ++     R + A   A +  P+ 
Sbjct: 226 RQERQERERLERLERERQE-------RERQEQLEREQLEWERERRISSAAAPASVETPLN 278

Query: 125 AGHGGAGGTDRGAQHRAEGDQRPRRAAAEPGGAGCRHHPEPIPRPTEGGVVARAEPGQP 183
           +  G +  ++ G Q  ++  + P +     G       P   P P +  V     PG P
Sbjct: 279 SVLGDSSASEPGLQAASQPAETPSQQGIVLGPLAPPPPPPLPPGPAQASVALPPPPGPP 337


>gi|39930375 enabled homolog isoform b [Homo sapiens]
          Length = 570

 Score = 38.9 bits (89), Expect = 0.006
 Identities = 41/179 (22%), Positives = 77/179 (43%), Gaps = 11/179 (6%)

Query: 6   DQVERDILETQKRLQQDRLNSEQSQALQHQQETGSSLKEAEVLLKDLFLDVDKARRLKHP 65
           +++ER+ LE ++RL+++RL  EQ +  + ++E    L+  E L +   L  ++  RL   
Sbjct: 169 ERLERERLE-RERLERERLEQEQLERERQERERQERLERQERLERQERL--ERQERLDRE 225

Query: 66  QAEETEKDIEQLHERVTQECAEYCALYEKMVLPPRRGIQGRLGTR-AGAETEAGLRRPVW 124
           + E  E++  +  ER  QE        E+     R  ++     R + A   A +  P+ 
Sbjct: 226 RQERQERERLERLERERQE-------RERQEQLEREQLEWERERRISSAAAPASVETPLN 278

Query: 125 AGHGGAGGTDRGAQHRAEGDQRPRRAAAEPGGAGCRHHPEPIPRPTEGGVVARAEPGQP 183
           +  G +  ++ G Q  ++  + P +     G       P   P P +  V     PG P
Sbjct: 279 SVLGDSSASEPGLQAASQPAETPSQQGIVLGPLAPPPPPPLPPGPAQASVALPPPPGPP 337


>gi|4503509 eukaryotic translation initiation factor 3, subunit 10
            theta, 150/170kDa [Homo sapiens]
          Length = 1382

 Score = 37.0 bits (84), Expect = 0.021
 Identities = 36/167 (21%), Positives = 65/167 (38%), Gaps = 26/167 (15%)

Query: 99   PRRGIQGRLGTRAGAETEAGLRRPVWAGHGGAGG------------TDRGAQHRAEGDQR 146
            PRRG+    G R G + + G RR +    G   G             DRG    A+ D+ 
Sbjct: 1069 PRRGLDDDRGPRRGMDDDRGPRRGMDDDRGPRRGMDDDRGPRRGLDDDRGPWRNADDDRI 1128

Query: 147  PRRAAAEPGGAGCRHHPEPIPRPTEG------GVVARAEPGQPVHALQGCTWQLSALAEQ 200
            PRR A +  G       + + R  +       G  +R  P +P+    G  W+      +
Sbjct: 1129 PRRGAEDDRGPWRNMDDDRLSRRADDDRFPRRGDDSRPGPWRPLVKPGG--WR------E 1180

Query: 201  QRRILQQDWSDLMADPAGVRREYEHFKQHELLSQEQSVNQLEEDGKR 247
            + +  ++ W           RE++  K+ +  +Q++  N  + + +R
Sbjct: 1181 KEKAREESWGPPRESRPSEEREWDREKERDRDNQDREENDKDPERER 1227



 Score = 31.2 bits (69), Expect = 1.2
 Identities = 19/62 (30%), Positives = 29/62 (46%), Gaps = 3/62 (4%)

Query: 98   PPRRGIQGRLGTRAGAETEAGLRRPVWAGHG---GAGGTDRGAQHRAEGDQRPRRAAAEP 154
            PPRRG+    G+   A+ + G RR +    G   G    +R +   A+ D+ PRR   + 
Sbjct: 1017 PPRRGLDEDRGSWRTADEDRGPRRGMDDDRGPRRGGADDERSSWRNADDDRGPRRGLDDD 1076

Query: 155  GG 156
             G
Sbjct: 1077 RG 1078



 Score = 28.9 bits (63), Expect = 5.8
 Identities = 22/71 (30%), Positives = 27/71 (38%), Gaps = 12/71 (16%)

Query: 99   PRRGIQGRLGTRAGAETEAGLRR------PVWAGHGG------AGGTDRGAQHRAEGDQR 146
            PRRG+    G R G E +   RR      P W               DRG    A+ D+ 
Sbjct: 958  PRRGMDDDRGPRRGPEEDRFSRRGADDDRPSWRNTDDDRPPRRIADEDRGNWRHADDDRP 1017

Query: 147  PRRAAAEPGGA 157
            PRR   E  G+
Sbjct: 1018 PRRGLDEDRGS 1028


>gi|153791497 ciliary rootlet coiled-coil [Homo sapiens]
          Length = 2017

 Score = 36.6 bits (83), Expect = 0.028
 Identities = 63/249 (25%), Positives = 102/249 (40%), Gaps = 37/249 (14%)

Query: 14   ETQKRLQQDRLNSEQSQALQHQQETGSSLKEAEVLLKDLFLDVDKARRLKHPQAEETEKD 73
            E  +++ Q+RL++ + QAL   ++  SSL E    L+    D++  R        E E  
Sbjct: 1760 EHDRQVLQERLDAAR-QALSEARKQSSSLGEQVQTLRGEVADLELQR-------VEAEGQ 1811

Query: 74   IEQLHERVTQ-ECAEYCALYEKMVLPP-RRGIQGRLGT--RAGAETEAGLRRPVWAGHGG 129
            ++QL E + Q +  E  AL     L   RR +Q RLG+  RA A+ EA  R         
Sbjct: 1812 LQQLREVLRQRQEGEAAALNTVQKLQDERRLLQERLGSLQRALAQLEAEKRE-------- 1863

Query: 130  AGGTDRGAQHRAEGDQRPRRAAAEPGGAGCRHHPEPIPRPTEGGVVARAEPGQPVHALQG 189
                +R A    +     RR   +      R H + +    E G + R   G  +     
Sbjct: 1864 ---VERSALRLEKDRVALRRTLDKVEREKLRSHEDTVRLSAEKGRLDRTLTGAELE---- 1916

Query: 190  CTWQLSALAEQQRRILQQDWSDLMADPAGVRREYEHFKQHELLSQEQSVNQL---EEDGK 246
                   LAE QR+I Q +   ++ + +    + E   Q + L  +Q V +L   +   +
Sbjct: 1917 -------LAEAQRQIQQLEAQVVVLEQSHSPAQLEVDAQQQQLELQQEVERLRSAQAQTE 1969

Query: 247  RMVELRHPA 255
            R +E R  A
Sbjct: 1970 RTLEARERA 1978



 Score = 34.3 bits (77), Expect = 0.14
 Identities = 54/208 (25%), Positives = 78/208 (37%), Gaps = 29/208 (13%)

Query: 1    MQASADQVERDILETQKRLQQDR-----LNSEQSQALQHQQETGSSLKEAEVLLKDLFLD 55
            ++    +VER  LE ++ LQ+ R     L+SE ++  +   E    L   E   K+   +
Sbjct: 1264 LRTGLQEVERSRLEARRELQELRRQMKMLDSENTRLGRELAELQGRLALGERAEKESRRE 1323

Query: 56   VD--KARRLKHPQAEETEKDIEQLHERVTQE--------------CAEYCALYEKMVLPP 99
                + R LK   + E  +   Q+ +R  QE                E     EK  L  
Sbjct: 1324 TLGLRQRLLKGEASLEVMRQELQVAQRKLQEQEGEFRTRERRLLGSLEEARGTEKQQLDH 1383

Query: 100  RRGIQGRLGTRAGAETEAGLRRPVWAGHGGAGGTDRG-----AQHRAEGDQRPRRAAAEP 154
             RG++ +L        E GLR  + A  G A G +        Q RA   Q     +A  
Sbjct: 1384 ARGLELKLEAARAEAAELGLR--LSAAEGRAQGLEAELARVEVQRRAAEAQLGGLRSALR 1441

Query: 155  GGAGCRHHPEPIPRPTEGGVVARAEPGQ 182
             G G    P P PRP  G   AR  P +
Sbjct: 1442 RGLGLGRAPSPAPRPVPGS-PARDAPAE 1468


>gi|92091575 coiled-coil domain containing 57 [Homo sapiens]
          Length = 915

 Score = 36.2 bits (82), Expect = 0.036
 Identities = 22/58 (37%), Positives = 34/58 (58%), Gaps = 1/58 (1%)

Query: 2   QASADQVERDILETQKRLQQDRLNSEQSQALQHQQETGSSLKEAEVLLKDLFLDVDKA 59
           Q   D +ERD ++  + L Q  L+  +SQ     QET  +L+E EV+LK + L+ D+A
Sbjct: 431 QRRCDDIERDQIQKSEALIQG-LSMAKSQVAAKLQETEQALQEQEVVLKAVTLERDQA 487


>gi|110349772 alpha 1 type I collagen preproprotein [Homo sapiens]
          Length = 1464

 Score = 35.8 bits (81), Expect = 0.048
 Identities = 33/89 (37%), Positives = 37/89 (41%), Gaps = 7/89 (7%)

Query: 98  PPRRGIQGRLGTRAGAETEAGLRRPVWAGHGGAGGTDRGAQHRA--EGDQRPRRAAAEPG 155
           P   G  G++G R G   E G  RP   G  GA G D GA   A   G   P      PG
Sbjct: 292 PGENGAPGQMGPR-GLPGERG--RPGAPGPAGARGND-GATGAAGPPGPTGPAGPPGFPG 347

Query: 156 GAGCRHHPEPI-PRPTEGGVVARAEPGQP 183
             G +    P  PR +EG    R EPG P
Sbjct: 348 AVGAKGEAGPQGPRGSEGPQGVRGEPGPP 376



 Score = 30.0 bits (66), Expect = 2.6
 Identities = 32/93 (34%), Positives = 42/93 (45%), Gaps = 11/93 (11%)

Query: 97  LPPRRGIQGRLGTRAGAETEAGLRRPVWAGHGGAGGTDR--GAQHRAE--GDQRPRRAAA 152
           LP  +G+ G  G+  G + + G   P  AG  G  G     GA+ +A   G   P+ AA 
Sbjct: 534 LPGAKGLTGSPGS-PGPDGKTGPPGP--AGQDGRPGPPGPPGARGQAGVMGFPGPKGAAG 590

Query: 153 EPGGAGCRHHPEPI----PRPTEGGVVARAEPG 181
           EPG AG R  P P     P   +G   A+  PG
Sbjct: 591 EPGKAGERGVPGPPGAVGPAGKDGEAGAQGPPG 623



 Score = 29.3 bits (64), Expect = 4.4
 Identities = 32/94 (34%), Positives = 38/94 (40%), Gaps = 13/94 (13%)

Query: 102 GIQGRLGTRAGAETEAGLR-RPVWAGHGGAGGTDRGAQHR----AEGDQRPRRAAAE--- 153
           G+QG  G  AG E + G R  P   G  G  G   G   R    A+G   P+  A E   
Sbjct: 455 GVQGPPGP-AGEEGKRGARGEPGPTGLPGPPGERGGPGSRGFPGADGVAGPKGPAGERGS 513

Query: 154 PGGAGCRHHPEPIPRPTEGGVVA----RAEPGQP 183
           PG AG +  P    RP E G+         PG P
Sbjct: 514 PGPAGPKGSPGEAGRPGEAGLPGAKGLTGSPGSP 547


>gi|4507831 Unc-51-like kinase 1 [Homo sapiens]
          Length = 1050

 Score = 35.4 bits (80), Expect = 0.062
 Identities = 26/87 (29%), Positives = 34/87 (39%), Gaps = 18/87 (20%)

Query: 121 RPVWAGHGGAGGTD-RGAQHRAEGDQRPRRAAAEPGGAGCRHHPEP-----------IPR 168
           RP W+G     G + RG +    G   P  +     G GCR H  P           +P+
Sbjct: 514 RPGWSGTPSPQGAEMRGGRSPRPGSSAPEHSP-RTSGLGCRLHSAPNLSDLHVVRPKLPK 572

Query: 169 PTEGGVVA-----RAEPGQPVHALQGC 190
           P    + A     +A P QP H LQ C
Sbjct: 573 PPTDPLGAVFSPPQASPPQPSHGLQSC 599


>gi|169171388 PREDICTED: hypothetical protein [Homo sapiens]
          Length = 154

 Score = 35.0 bits (79), Expect = 0.081
 Identities = 23/55 (41%), Positives = 27/55 (49%), Gaps = 3/55 (5%)

Query: 128 GGAGGTDRGAQHRAEGDQRPRRAAAEPGGAGCRHHP--EPIPRPTEG-GVVARAE 179
           GG GG   GA+  A G  R R  A      G R HP  EP P+  +G G  ARA+
Sbjct: 52  GGGGGGAGGAEGGAGGAGRARERAESGRPCGRRRHPQAEPAPKEFQGDGAAARAD 106


  Database: hs.faa
    Posted date:  Aug 4, 2009  4:42 PM
  Number of letters in database: 18,247,518
  Number of sequences in database:  37,866
  
Lambda     K      H
   0.315    0.131    0.392 

Gapped
Lambda     K      H
   0.267   0.0410    0.140 


Matrix: BLOSUM62
Gap Penalties: Existence: 11, Extension: 1
Number of Hits to DB: 13,141,222
Number of Sequences: 37866
Number of extensions: 698082
Number of successful extensions: 4356
Number of sequences better than 10.0: 30
Number of HSP's better than 10.0 without gapping: 71
Number of HSP's successfully gapped in prelim test: 258
Number of HSP's that attempted gapping in prelim test: 3902
Number of HSP's gapped (non-prelim): 716
length of query: 301
length of database: 18,247,518
effective HSP length: 102
effective length of query: 199
effective length of database: 14,385,186
effective search space: 2862652014
effective search space used: 2862652014
T: 11
A: 40
X1: 16 ( 7.3 bits)
X2: 38 (14.6 bits)
X3: 64 (24.7 bits)
S1: 41 (21.6 bits)
S2: 61 (28.1 bits)

Search results were obtained with NCBI BLAST and RefSeq entries.


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Guide to the Human Genome
Copyright © 2010 by Stewart Scherer. All rights reserved.

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