Guide to the Human Genome
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Search of human proteins with 223029422

BLASTP 2.2.11 [Jun-05-2005]


Reference: Altschul, Stephen F., Thomas L. Madden, Alejandro A. Schaffer, 
Jinghui Zhang, Zheng Zhang, Webb Miller, and David J. Lipman (1997), 
"Gapped BLAST and PSI-BLAST: a new generation of protein database search
programs",  Nucleic Acids Res. 25:3389-3402.

Query= gi|223029422 SKI-like isoform 3 [Homo sapiens]
         (664 letters)

Database: hs.faa 
           37,866 sequences; 18,247,518 total letters

Searching..................................................done

                                                                 Score    E
Sequences producing significant alignments:                      (bits) Value

gi|223029422 SKI-like isoform 3 [Homo sapiens]                       1327   0.0  
gi|223029418 SKI-like isoform 1 [Homo sapiens]                       1327   0.0  
gi|223029420 SKI-like isoform 2 [Homo sapiens]                       1215   0.0  
gi|4506967 v-ski sarcoma viral oncogene homolog [Homo sapiens]        426   e-119
gi|239757043 PREDICTED: functional smad suppressing element 18 [...   121   2e-27
gi|239751555 PREDICTED: functional smad suppressing element 18 [...   121   2e-27
gi|239746067 PREDICTED: functional smad suppressing element 18 [...   121   2e-27
gi|73476377 LBXCOR1 homolog [Homo sapiens]                            109   9e-24
gi|41406064 myosin, heavy polypeptide 10, non-muscle [Homo sapiens]    60   5e-09
gi|50897852 coiled-coil domain containing 88A isoform 2 [Homo sa...    59   2e-08
gi|208022632 coiled-coil domain containing 88A isoform 1 [Homo s...    59   2e-08
gi|41322923 plectin 1 isoform 11 [Homo sapiens]                        57   7e-08
gi|41322914 plectin 1 isoform 10 [Homo sapiens]                        57   7e-08
gi|41322919 plectin 1 isoform 8 [Homo sapiens]                         57   7e-08
gi|41322910 plectin 1 isoform 7 [Homo sapiens]                         57   7e-08
gi|41322916 plectin 1 isoform 6 [Homo sapiens]                         57   7e-08
gi|41322908 plectin 1 isoform 3 [Homo sapiens]                         57   7e-08
gi|41322912 plectin 1 isoform 2 [Homo sapiens]                         57   7e-08
gi|47607492 plectin 1 isoform 1 [Homo sapiens]                         57   7e-08
gi|21735548 centrosomal protein 2 [Homo sapiens]                       56   9e-08
gi|63252902 tropomyosin 1 alpha chain isoform 2 [Homo sapiens]         55   2e-07
gi|41872583 Rho-associated, coiled-coil containing protein kinas...    55   3e-07
gi|148746195 trichohyalin [Homo sapiens]                               54   4e-07
gi|31982906 cingulin-like 1 [Homo sapiens]                             54   5e-07
gi|148596984 golgi autoantigen, golgin subfamily b, macrogolgin ...    54   5e-07
gi|239745095 PREDICTED: hypothetical protein LOC645202 [Homo sap...    54   6e-07
gi|71361682 nuclear mitotic apparatus protein 1 [Homo sapiens]         54   6e-07
gi|222418637 golgi autoantigen, golgin subfamily a-like [Homo sa...    53   8e-07
gi|22538387 A-kinase anchor protein 9 isoform 2 [Homo sapiens]         53   8e-07
gi|22538393 A-kinase anchor protein 9 isoform 3 [Homo sapiens]         53   8e-07

>gi|223029422 SKI-like isoform 3 [Homo sapiens]
          Length = 664

 Score = 1327 bits (3435), Expect = 0.0
 Identities = 664/664 (100%), Positives = 664/664 (100%)

Query: 1   MGDDGSPPAKKMITDIHANGKTINKVPTVKKEHLDDYGEAPVETDGEHVKRTCTSVPETL 60
           MGDDGSPPAKKMITDIHANGKTINKVPTVKKEHLDDYGEAPVETDGEHVKRTCTSVPETL
Sbjct: 1   MGDDGSPPAKKMITDIHANGKTINKVPTVKKEHLDDYGEAPVETDGEHVKRTCTSVPETL 60

Query: 61  HLNPSLKHTLAQFHLSSQSSLGGPAAFSARHSQESMSPTVFLPLPSPQVLPGPLLIPSDS 120
           HLNPSLKHTLAQFHLSSQSSLGGPAAFSARHSQESMSPTVFLPLPSPQVLPGPLLIPSDS
Sbjct: 61  HLNPSLKHTLAQFHLSSQSSLGGPAAFSARHSQESMSPTVFLPLPSPQVLPGPLLIPSDS 120

Query: 121 STELTQTVLEGESISCFQVGGEKRLCLPQVLNSVLREFTLQQINTVCDELYIYCSRCTSD 180
           STELTQTVLEGESISCFQVGGEKRLCLPQVLNSVLREFTLQQINTVCDELYIYCSRCTSD
Sbjct: 121 STELTQTVLEGESISCFQVGGEKRLCLPQVLNSVLREFTLQQINTVCDELYIYCSRCTSD 180

Query: 181 QLHILKVLGILPFNAPSCGLITLTDAQRLCNALLRPRTFPQNGSVLPAKSSLAQLKETGS 240
           QLHILKVLGILPFNAPSCGLITLTDAQRLCNALLRPRTFPQNGSVLPAKSSLAQLKETGS
Sbjct: 181 QLHILKVLGILPFNAPSCGLITLTDAQRLCNALLRPRTFPQNGSVLPAKSSLAQLKETGS 240

Query: 241 AFEVEHECLGKCQGLFAPQFYVQPDAPCIQCLECCGMFAPQTFVMHSHRSPDKRTCHWGF 300
           AFEVEHECLGKCQGLFAPQFYVQPDAPCIQCLECCGMFAPQTFVMHSHRSPDKRTCHWGF
Sbjct: 241 AFEVEHECLGKCQGLFAPQFYVQPDAPCIQCLECCGMFAPQTFVMHSHRSPDKRTCHWGF 300

Query: 301 ESAKWHCYLHVNQKYLGTPEEKKLKIILEEMKEKFSMRSGKRNQSKTDAPSGMELQSWYP 360
           ESAKWHCYLHVNQKYLGTPEEKKLKIILEEMKEKFSMRSGKRNQSKTDAPSGMELQSWYP
Sbjct: 301 ESAKWHCYLHVNQKYLGTPEEKKLKIILEEMKEKFSMRSGKRNQSKTDAPSGMELQSWYP 360

Query: 361 VIKQEGDHVSQTHSFLHPSYYLYMCDKVVAPNVSLTSAVSQSKELTKTEASKSISRQSEK 420
           VIKQEGDHVSQTHSFLHPSYYLYMCDKVVAPNVSLTSAVSQSKELTKTEASKSISRQSEK
Sbjct: 361 VIKQEGDHVSQTHSFLHPSYYLYMCDKVVAPNVSLTSAVSQSKELTKTEASKSISRQSEK 420

Query: 421 AHSSGKLQKTVSYPDVSLEEQEKMDLKTSRELCSRLDASISNNSTSKRKSESATCNLVRD 480
           AHSSGKLQKTVSYPDVSLEEQEKMDLKTSRELCSRLDASISNNSTSKRKSESATCNLVRD
Sbjct: 421 AHSSGKLQKTVSYPDVSLEEQEKMDLKTSRELCSRLDASISNNSTSKRKSESATCNLVRD 480

Query: 481 INKVGIGLVAAASSPLLVKDVICEDDKGKIMEEVMRTYLKQQEKLNLILQKKQQLQMEVK 540
           INKVGIGLVAAASSPLLVKDVICEDDKGKIMEEVMRTYLKQQEKLNLILQKKQQLQMEVK
Sbjct: 481 INKVGIGLVAAASSPLLVKDVICEDDKGKIMEEVMRTYLKQQEKLNLILQKKQQLQMEVK 540

Query: 541 MLSSSKSMKELTEEQQNLQKELESLQNEHAQRMEEFYVEQKDLEKKLEQIMKQKCTCDSN 600
           MLSSSKSMKELTEEQQNLQKELESLQNEHAQRMEEFYVEQKDLEKKLEQIMKQKCTCDSN
Sbjct: 541 MLSSSKSMKELTEEQQNLQKELESLQNEHAQRMEEFYVEQKDLEKKLEQIMKQKCTCDSN 600

Query: 601 LEKDKEAEYAGQLAELRQRLDHAEADRQELQDELRQEREARQKLEMMIKELKLQILKSSK 660
           LEKDKEAEYAGQLAELRQRLDHAEADRQELQDELRQEREARQKLEMMIKELKLQILKSSK
Sbjct: 601 LEKDKEAEYAGQLAELRQRLDHAEADRQELQDELRQEREARQKLEMMIKELKLQILKSSK 660

Query: 661 TAKE 664
           TAKE
Sbjct: 661 TAKE 664


>gi|223029418 SKI-like isoform 1 [Homo sapiens]
          Length = 684

 Score = 1327 bits (3435), Expect = 0.0
 Identities = 664/664 (100%), Positives = 664/664 (100%)

Query: 1   MGDDGSPPAKKMITDIHANGKTINKVPTVKKEHLDDYGEAPVETDGEHVKRTCTSVPETL 60
           MGDDGSPPAKKMITDIHANGKTINKVPTVKKEHLDDYGEAPVETDGEHVKRTCTSVPETL
Sbjct: 21  MGDDGSPPAKKMITDIHANGKTINKVPTVKKEHLDDYGEAPVETDGEHVKRTCTSVPETL 80

Query: 61  HLNPSLKHTLAQFHLSSQSSLGGPAAFSARHSQESMSPTVFLPLPSPQVLPGPLLIPSDS 120
           HLNPSLKHTLAQFHLSSQSSLGGPAAFSARHSQESMSPTVFLPLPSPQVLPGPLLIPSDS
Sbjct: 81  HLNPSLKHTLAQFHLSSQSSLGGPAAFSARHSQESMSPTVFLPLPSPQVLPGPLLIPSDS 140

Query: 121 STELTQTVLEGESISCFQVGGEKRLCLPQVLNSVLREFTLQQINTVCDELYIYCSRCTSD 180
           STELTQTVLEGESISCFQVGGEKRLCLPQVLNSVLREFTLQQINTVCDELYIYCSRCTSD
Sbjct: 141 STELTQTVLEGESISCFQVGGEKRLCLPQVLNSVLREFTLQQINTVCDELYIYCSRCTSD 200

Query: 181 QLHILKVLGILPFNAPSCGLITLTDAQRLCNALLRPRTFPQNGSVLPAKSSLAQLKETGS 240
           QLHILKVLGILPFNAPSCGLITLTDAQRLCNALLRPRTFPQNGSVLPAKSSLAQLKETGS
Sbjct: 201 QLHILKVLGILPFNAPSCGLITLTDAQRLCNALLRPRTFPQNGSVLPAKSSLAQLKETGS 260

Query: 241 AFEVEHECLGKCQGLFAPQFYVQPDAPCIQCLECCGMFAPQTFVMHSHRSPDKRTCHWGF 300
           AFEVEHECLGKCQGLFAPQFYVQPDAPCIQCLECCGMFAPQTFVMHSHRSPDKRTCHWGF
Sbjct: 261 AFEVEHECLGKCQGLFAPQFYVQPDAPCIQCLECCGMFAPQTFVMHSHRSPDKRTCHWGF 320

Query: 301 ESAKWHCYLHVNQKYLGTPEEKKLKIILEEMKEKFSMRSGKRNQSKTDAPSGMELQSWYP 360
           ESAKWHCYLHVNQKYLGTPEEKKLKIILEEMKEKFSMRSGKRNQSKTDAPSGMELQSWYP
Sbjct: 321 ESAKWHCYLHVNQKYLGTPEEKKLKIILEEMKEKFSMRSGKRNQSKTDAPSGMELQSWYP 380

Query: 361 VIKQEGDHVSQTHSFLHPSYYLYMCDKVVAPNVSLTSAVSQSKELTKTEASKSISRQSEK 420
           VIKQEGDHVSQTHSFLHPSYYLYMCDKVVAPNVSLTSAVSQSKELTKTEASKSISRQSEK
Sbjct: 381 VIKQEGDHVSQTHSFLHPSYYLYMCDKVVAPNVSLTSAVSQSKELTKTEASKSISRQSEK 440

Query: 421 AHSSGKLQKTVSYPDVSLEEQEKMDLKTSRELCSRLDASISNNSTSKRKSESATCNLVRD 480
           AHSSGKLQKTVSYPDVSLEEQEKMDLKTSRELCSRLDASISNNSTSKRKSESATCNLVRD
Sbjct: 441 AHSSGKLQKTVSYPDVSLEEQEKMDLKTSRELCSRLDASISNNSTSKRKSESATCNLVRD 500

Query: 481 INKVGIGLVAAASSPLLVKDVICEDDKGKIMEEVMRTYLKQQEKLNLILQKKQQLQMEVK 540
           INKVGIGLVAAASSPLLVKDVICEDDKGKIMEEVMRTYLKQQEKLNLILQKKQQLQMEVK
Sbjct: 501 INKVGIGLVAAASSPLLVKDVICEDDKGKIMEEVMRTYLKQQEKLNLILQKKQQLQMEVK 560

Query: 541 MLSSSKSMKELTEEQQNLQKELESLQNEHAQRMEEFYVEQKDLEKKLEQIMKQKCTCDSN 600
           MLSSSKSMKELTEEQQNLQKELESLQNEHAQRMEEFYVEQKDLEKKLEQIMKQKCTCDSN
Sbjct: 561 MLSSSKSMKELTEEQQNLQKELESLQNEHAQRMEEFYVEQKDLEKKLEQIMKQKCTCDSN 620

Query: 601 LEKDKEAEYAGQLAELRQRLDHAEADRQELQDELRQEREARQKLEMMIKELKLQILKSSK 660
           LEKDKEAEYAGQLAELRQRLDHAEADRQELQDELRQEREARQKLEMMIKELKLQILKSSK
Sbjct: 621 LEKDKEAEYAGQLAELRQRLDHAEADRQELQDELRQEREARQKLEMMIKELKLQILKSSK 680

Query: 661 TAKE 664
           TAKE
Sbjct: 681 TAKE 684


>gi|223029420 SKI-like isoform 2 [Homo sapiens]
          Length = 638

 Score = 1215 bits (3143), Expect = 0.0
 Identities = 616/664 (92%), Positives = 617/664 (92%), Gaps = 46/664 (6%)

Query: 1   MGDDGSPPAKKMITDIHANGKTINKVPTVKKEHLDDYGEAPVETDGEHVKRTCTSVPETL 60
           MGDDGSPPAKKMITDIHANGKTINKVPTVKKEHLDDYGEAPVETDGEHVKRTCTSVPETL
Sbjct: 21  MGDDGSPPAKKMITDIHANGKTINKVPTVKKEHLDDYGEAPVETDGEHVKRTCTSVPETL 80

Query: 61  HLNPSLKHTLAQFHLSSQSSLGGPAAFSARHSQESMSPTVFLPLPSPQVLPGPLLIPSDS 120
           HLNPSLKHTLAQFHLSSQSSLGGPAAFSARHSQESMSPTVFLPLPSPQVLPGPLLIPSDS
Sbjct: 81  HLNPSLKHTLAQFHLSSQSSLGGPAAFSARHSQESMSPTVFLPLPSPQVLPGPLLIPSDS 140

Query: 121 STELTQTVLEGESISCFQVGGEKRLCLPQVLNSVLREFTLQQINTVCDELYIYCSRCTSD 180
           STELTQTVLEGESISCFQVGGEKRLCLPQVLNSVLREFTLQQINTVCDELYIYCSRCTSD
Sbjct: 141 STELTQTVLEGESISCFQVGGEKRLCLPQVLNSVLREFTLQQINTVCDELYIYCSRCTSD 200

Query: 181 QLHILKVLGILPFNAPSCGLITLTDAQRLCNALLRPRTFPQNGSVLPAKSSLAQLKETGS 240
           QLHILKVLGILPFNAPSCGLITLTDAQRLCNALLRPRTFPQNGSVLPAKSSLAQLKETGS
Sbjct: 201 QLHILKVLGILPFNAPSCGLITLTDAQRLCNALLRPRTFPQNGSVLPAKSSLAQLKETGS 260

Query: 241 AFEVEHECLGKCQGLFAPQFYVQPDAPCIQCLECCGMFAPQTFVMHSHRSPDKRTCHWGF 300
           AFEVEHECLGKCQGLFAPQFYVQPDAPCIQCLECCGMFAPQTFVMHSHRSPDKRTCHWGF
Sbjct: 261 AFEVEHECLGKCQGLFAPQFYVQPDAPCIQCLECCGMFAPQTFVMHSHRSPDKRTCHWGF 320

Query: 301 ESAKWHCYLHVNQKYLGTPEEKKLKIILEEMKEKFSMRSGKRNQSKTDAPSGMELQSWYP 360
           ESAKWHCYLHVNQKYLGTPEEKKLKIILEEMKEKFSMRSGKRNQSKTDAPSGMELQSWYP
Sbjct: 321 ESAKWHCYLHVNQKYLGTPEEKKLKIILEEMKEKFSMRSGKRNQSKTDAPSGMELQSWYP 380

Query: 361 VIKQEGDHVSQTHSFLHPSYYLYMCDKVVAPNVSLTSAVSQSKELTKTEASKSISRQSEK 420
           VIKQEGDHVSQTHSFLHPSYYLYMCDKVVAPNVSLTSAVSQSKELTKTEA+ SIS     
Sbjct: 381 VIKQEGDHVSQTHSFLHPSYYLYMCDKVVAPNVSLTSAVSQSKELTKTEANASIS----- 435

Query: 421 AHSSGKLQKTVSYPDVSLEEQEKMDLKTSRELCSRLDASISNNSTSKRKSESATCNLVRD 480
                                                    NNSTSKRKSESATCNLVRD
Sbjct: 436 -----------------------------------------NNSTSKRKSESATCNLVRD 454

Query: 481 INKVGIGLVAAASSPLLVKDVICEDDKGKIMEEVMRTYLKQQEKLNLILQKKQQLQMEVK 540
           INKVGIGLVAAASSPLLVKDVICEDDKGKIMEEVMRTYLKQQEKLNLILQKKQQLQMEVK
Sbjct: 455 INKVGIGLVAAASSPLLVKDVICEDDKGKIMEEVMRTYLKQQEKLNLILQKKQQLQMEVK 514

Query: 541 MLSSSKSMKELTEEQQNLQKELESLQNEHAQRMEEFYVEQKDLEKKLEQIMKQKCTCDSN 600
           MLSSSKSMKELTEEQQNLQKELESLQNEHAQRMEEFYVEQKDLEKKLEQIMKQKCTCDSN
Sbjct: 515 MLSSSKSMKELTEEQQNLQKELESLQNEHAQRMEEFYVEQKDLEKKLEQIMKQKCTCDSN 574

Query: 601 LEKDKEAEYAGQLAELRQRLDHAEADRQELQDELRQEREARQKLEMMIKELKLQILKSSK 660
           LEKDKEAEYAGQLAELRQRLDHAEADRQELQDELRQEREARQKLEMMIKELKLQILKSSK
Sbjct: 575 LEKDKEAEYAGQLAELRQRLDHAEADRQELQDELRQEREARQKLEMMIKELKLQILKSSK 634

Query: 661 TAKE 664
           TAKE
Sbjct: 635 TAKE 638


>gi|4506967 v-ski sarcoma viral oncogene homolog [Homo sapiens]
          Length = 728

 Score =  426 bits (1095), Expect = e-119
 Identities = 262/698 (37%), Positives = 384/698 (55%), Gaps = 107/698 (15%)

Query: 63  NPSLKHTLAQFHLSSQSSLGGPAAFSARHSQESMS-----------------------PT 99
           +P L+ TL QFHLSS SSLGGPAAFSAR +QE+                         P 
Sbjct: 14  HPGLQKTLEQFHLSSMSSLGGPAAFSARWAQEAYKKESAKEAGAAAVPAPVPAATEPPPV 73

Query: 100 VFLPL--PSPQVLPGPLLIPSDSSTELTQTVLEGESISCFQVGGEKRLCLPQVLNSVLRE 157
           + LP   P P VLPGP  +PSD STE  +TVLEGE+ISCF VGGEKRLCLPQ+LNSVLR+
Sbjct: 74  LHLPAIQPPPPVLPGPFFMPSDRSTERCETVLEGETISCFVVGGEKRLCLPQILNSVLRD 133

Query: 158 FTLQQINTVCDELYIYCSRCTSDQLHILKVLGILPFNAPSCGLITLTDAQRLCNALLRPR 217
           F+LQQIN VCDEL+IYCSRCT+DQL ILKV+GILPF+APSCGLIT TDA+RLCNALL   
Sbjct: 134 FSLQQINAVCDELHIYCSRCTADQLEILKVMGILPFSAPSCGLITKTDAERLCNALLYGG 193

Query: 218 TFPQNGSVLPAKSSLAQLKETGSAFEVEHECLGKCQGLFAPQFYVQPDAPCIQCLECCGM 277
            +P       A S    L+ +  +  V HEC GKC+GL  P+ Y  P A CIQCL+C  M
Sbjct: 194 AYPPPCKKELAASLALGLELSERSVRVYHECFGKCKGLLVPELYSSPSAACIQCLDCRLM 253

Query: 278 FAPQTFVMHSHRSPDKRTCHWGFESAKWHCYLHVNQKYLGTPEEKKLKIILEEMKEKFSM 337
           + P  FV+HSH++ + RTCHWGF+SA W  Y+ ++Q Y G  E+ +L   L+++KEKF  
Sbjct: 254 YPPHKFVVHSHKALENRTCHWGFDSANWRAYILLSQDYTGKEEQARLGRCLDDVKEKFDY 313

Query: 338 RSGKRNQ--------------------SKTDAPSGMELQS-------------------- 357
            +  + +                    S++ APS  +  S                    
Sbjct: 314 GNKYKRRVPRVSSEPPASIRPKTDDTSSQSPAPSEKDKPSSWLRTLAGSSNKSLGCVHPR 373

Query: 358 --------WYPVIKQEGDHVS-QTHSFLHPSYYLYMC-DKVVAPNVSLTSAVSQSKELTK 407
                   W P +      +S    + +  S+Y Y   +  VAPNV+L +  +Q K ++ 
Sbjct: 374 QRLSAFRPWSPAVSASEKELSPHLPALIRDSFYSYKSFETAVAPNVAL-APPAQQKVVSS 432

Query: 408 TEASKSISRQSEKAHSSGKLQK---------------TVSYPDVSLEEQEKMDLKTSREL 452
              + ++SR  E   +  + +K                V+ P+   + + ++++++  E 
Sbjct: 433 PPCAAAVSRAPEPLATCTQPRKRKLTVDTPGAPETLAPVAAPEEDKDSEAEVEVESREEF 492

Query: 453 CSRLDASISNNSTSKRKSESATCNLVRDINKVGIGLVAAASSP------------LLVKD 500
            S L +  S + TS   ++       R +        A A +P             L   
Sbjct: 493 TSSLSSLSSPSFTSSSSAKDLGSPGARALPSAVPDAAAPADAPSGLEAELEHLRQALEGG 552

Query: 501 VICEDDKGKIMEEVMRTYLKQQEKLNLILQKKQQLQMEVKMLSSSK--SMKELTEEQQNL 558
           +  ++ K K + EV++  +KQ+EKL+  LQ K+ L  E++ L  +K   ++E TE ++NL
Sbjct: 553 LDTKEAKEKFLHEVVKMRVKQEEKLSAALQAKRSLHQELEFLRVAKKEKLREATEAKRNL 612

Query: 559 QKELESLQNEHAQRMEEFYVEQKDLEKKLEQIMKQKCTCDSNLEKDK-EAEYAGQLAELR 617
           +KE+E L+ E+ ++M+E    +  L+++LEQ  +Q   CD   E  +  A+Y+ Q+ +L+
Sbjct: 613 RKEIERLRAENEKKMKEANESRLRLKRELEQ-ARQARVCDKGCEAGRLRAKYSAQIEDLQ 671

Query: 618 QRLDHAEADRQELQDELRQEREARQKLEMMIKELKLQI 655
            +L HAEADR++L+ +L +EREAR+ LE ++KEL+ Q+
Sbjct: 672 VKLQHAEADREQLRADLLREREAREHLEKVVKELQEQL 709


>gi|239757043 PREDICTED: functional smad suppressing element 18
           [Homo sapiens]
          Length = 996

 Score =  121 bits (304), Expect = 2e-27
 Identities = 83/252 (32%), Positives = 119/252 (47%), Gaps = 30/252 (11%)

Query: 100 VFLPLPSPQVLPGPLLIPSDSSTELT-----QTVLEGESISCFQVGGEKRLCLPQVLNSV 154
           + L  PS    P  L  P      L      Q +L G  I    + G++RLCL Q+ N++
Sbjct: 12  ILLASPSSAFQPDTLSQPRPGHANLKPNQVGQVILYGIPIVSLVIDGQERLCLAQISNTL 71

Query: 155 LREFTLQQINTVCDELYIYCSRCTSDQLHILKVLGILPFNAPSCGLITLTDAQRLCNALL 214
           L+ F+  +I+     L I C +CT  QL IL+  G +P ++  CG+IT  +A+RLC + L
Sbjct: 72  LKNFSYNEIHNRRVALGITCVQCTPVQLEILRRAGAMPISSRRCGMITKREAERLCKSFL 131

Query: 215 ---RPRTFPQNGSVLPAKSSLAQLKETGSAFEVEHECLGKCQGLFAPQFYVQPDAPCIQC 271
              RP   P N                  AF+V HEC   C+G F P  Y    A CI+C
Sbjct: 132 GENRPPKLPDN-----------------FAFDVSHECAWGCRGSFIPARYNSSRAKCIKC 174

Query: 272 LECCGMFAPQTFVMHSHRSPD-KRTCHWGFESAKWHCYLHVNQKYLGTPEEKKLKIILEE 330
             C   F+P  F+ HSHR+PD K T         W  +L +  K   +P++ +L    E+
Sbjct: 175 SYCNMYFSPNKFIFHSHRTPDAKYTQPDAANFNSWRRHLKLTDK---SPQD-ELVFAWED 230

Query: 331 MKEKFSMRSGKR 342
           +K  F+  S KR
Sbjct: 231 VKAMFNGGSRKR 242


>gi|239751555 PREDICTED: functional smad suppressing element 18
           [Homo sapiens]
          Length = 1252

 Score =  121 bits (304), Expect = 2e-27
 Identities = 83/252 (32%), Positives = 119/252 (47%), Gaps = 30/252 (11%)

Query: 100 VFLPLPSPQVLPGPLLIPSDSSTELT-----QTVLEGESISCFQVGGEKRLCLPQVLNSV 154
           + L  PS    P  L  P      L      Q +L G  I    + G++RLCL Q+ N++
Sbjct: 12  ILLASPSSAFQPDTLSQPRPGHANLKPNQVGQVILYGIPIVSLVIDGQERLCLAQISNTL 71

Query: 155 LREFTLQQINTVCDELYIYCSRCTSDQLHILKVLGILPFNAPSCGLITLTDAQRLCNALL 214
           L+ F+  +I+     L I C +CT  QL IL+  G +P ++  CG+IT  +A+RLC + L
Sbjct: 72  LKNFSYNEIHNRRVALGITCVQCTPVQLEILRRAGAMPISSRRCGMITKREAERLCKSFL 131

Query: 215 ---RPRTFPQNGSVLPAKSSLAQLKETGSAFEVEHECLGKCQGLFAPQFYVQPDAPCIQC 271
              RP   P N                  AF+V HEC   C+G F P  Y    A CI+C
Sbjct: 132 GENRPPKLPDN-----------------FAFDVSHECAWGCRGSFIPARYNSSRAKCIKC 174

Query: 272 LECCGMFAPQTFVMHSHRSPD-KRTCHWGFESAKWHCYLHVNQKYLGTPEEKKLKIILEE 330
             C   F+P  F+ HSHR+PD K T         W  +L +  K   +P++ +L    E+
Sbjct: 175 SYCNMYFSPNKFIFHSHRTPDAKYTQPDAANFNSWRRHLKLTDK---SPQD-ELVFAWED 230

Query: 331 MKEKFSMRSGKR 342
           +K  F+  S KR
Sbjct: 231 VKAMFNGGSRKR 242


>gi|239746067 PREDICTED: functional smad suppressing element 18
           [Homo sapiens]
          Length = 1252

 Score =  121 bits (304), Expect = 2e-27
 Identities = 83/252 (32%), Positives = 119/252 (47%), Gaps = 30/252 (11%)

Query: 100 VFLPLPSPQVLPGPLLIPSDSSTELT-----QTVLEGESISCFQVGGEKRLCLPQVLNSV 154
           + L  PS    P  L  P      L      Q +L G  I    + G++RLCL Q+ N++
Sbjct: 12  ILLASPSSAFQPDTLSQPRPGHANLKPNQVGQVILYGIPIVSLVIDGQERLCLAQISNTL 71

Query: 155 LREFTLQQINTVCDELYIYCSRCTSDQLHILKVLGILPFNAPSCGLITLTDAQRLCNALL 214
           L+ F+  +I+     L I C +CT  QL IL+  G +P ++  CG+IT  +A+RLC + L
Sbjct: 72  LKNFSYNEIHNRRVALGITCVQCTPVQLEILRRAGAMPISSRRCGMITKREAERLCKSFL 131

Query: 215 ---RPRTFPQNGSVLPAKSSLAQLKETGSAFEVEHECLGKCQGLFAPQFYVQPDAPCIQC 271
              RP   P N                  AF+V HEC   C+G F P  Y    A CI+C
Sbjct: 132 GENRPPKLPDN-----------------FAFDVSHECAWGCRGSFIPARYNSSRAKCIKC 174

Query: 272 LECCGMFAPQTFVMHSHRSPD-KRTCHWGFESAKWHCYLHVNQKYLGTPEEKKLKIILEE 330
             C   F+P  F+ HSHR+PD K T         W  +L +  K   +P++ +L    E+
Sbjct: 175 SYCNMYFSPNKFIFHSHRTPDAKYTQPDAANFNSWRRHLKLTDK---SPQD-ELVFAWED 230

Query: 331 MKEKFSMRSGKR 342
           +K  F+  S KR
Sbjct: 231 VKAMFNGGSRKR 242


>gi|73476377 LBXCOR1 homolog [Homo sapiens]
          Length = 921

 Score =  109 bits (272), Expect = 9e-24
 Identities = 60/175 (34%), Positives = 92/175 (52%), Gaps = 20/175 (11%)

Query: 123 ELTQTVLEGESISCFQVGGEKRLCLPQVLNSVLREFTLQQINTVCDELYIYCSRCTSDQL 182
           ++ +T L G  I    + G++RLCL Q+ N++L+ ++  +I+     L I C +CT  QL
Sbjct: 67  QVGETSLYGVPIVSLVIDGQERLCLAQISNTLLKNYSYNEIHNRRVALGITCVQCTPVQL 126

Query: 183 HILKVLGILPFNAPSCGLITLTDAQRLCNALL---RPRTFPQNGSVLPAKSSLAQLKETG 239
            IL+  G +P ++  CG+IT  +A+RLC + L   +P   P+N                 
Sbjct: 127 EILRRAGAMPISSRRCGMITKREAERLCKSFLGEHKPPKLPEN----------------- 169

Query: 240 SAFEVEHECLGKCQGLFAPQFYVQPDAPCIQCLECCGMFAPQTFVMHSHRSPDKR 294
            AF+V HEC    +G F P  Y    A CI+C  C   F+P  F+ HSHR+PD +
Sbjct: 170 FAFDVVHECAWGSRGSFIPARYNSSRAKCIKCGYCSMYFSPNKFIFHSHRTPDAK 224



 Score = 40.0 bits (92), Expect = 0.007
 Identities = 26/93 (27%), Positives = 51/93 (54%), Gaps = 10/93 (10%)

Query: 558 LQKELESLQNEHAQRMEEFYVEQKDLEKKLEQIMKQKCTCDSNLEKDKEAEYAGQLAELR 617
           ++K++E+L  E  Q++    +EQ +L KKLE+  +       +L+ + + +   +LA   
Sbjct: 809 VEKDIENLAREELQKL---LLEQMELRKKLEREFQ-------SLKDNFQDQMKRELAYRE 858

Query: 618 QRLDHAEADRQELQDELRQEREARQKLEMMIKE 650
           + +   +  R  L +EL QER+AR  ++  +KE
Sbjct: 859 EMVQQLQIVRDTLCNELDQERKARYAIQQKLKE 891


>gi|41406064 myosin, heavy polypeptide 10, non-muscle [Homo sapiens]
          Length = 1976

 Score = 60.5 bits (145), Expect = 5e-09
 Identities = 70/290 (24%), Positives = 132/290 (45%), Gaps = 35/290 (12%)

Query: 394  SLTSAVSQSKELTKTEASKSISRQSEKAHSSGKLQKTVSYPDVSLEEQEKMDLKTSRELC 453
            SL S +  ++EL + E         +K + S ++++     + SL+EQ++ + +  + L 
Sbjct: 1312 SLESQLQDTQELLQEETR-------QKLNLSSRIRQLEEEKN-SLQEQQEEEEEARKNLE 1363

Query: 454  SRLDASISNNSTSKRKSES--ATCNLVRDINKVGIGLVAAASSPLLVKDVI---CEDDKG 508
             ++ A  S  + +K+K +    T   + +  K  +    A S  L  K +     E  K 
Sbjct: 1364 KQVLALQSQLADTKKKVDDDLGTIESLEEAKKKLLKDAEALSQRLEEKALAYDKLEKTKN 1423

Query: 509  KIMEEV--MRTYLKQQEKLNLILQKKQ----QLQMEVKMLSSSKSMKELTEEQQNLQKEL 562
            ++ +E+  +   L  Q ++   L+KKQ    QL  E K +S+  + +    E +  +KE 
Sbjct: 1424 RLQQELDDLTVDLDHQRQVASNLEKKQKKFDQLLAEEKSISARYAEERDRAEAEAREKET 1483

Query: 563  ESLQ-----NEHAQRMEEFYVEQKDLEKKLEQIMKQKCTCDSN---LEKDKEAEYAGQLA 614
            ++L       E  +  EEF  + K L   +E +M  K     N   LEK K A       
Sbjct: 1484 KALSLARALEEALEAKEEFERQNKQLRADMEDLMSSKDDVGKNVHELEKSKRA------- 1536

Query: 615  ELRQRLDHAEADRQELQDELRQEREARQKLEMMIKELKLQILKSSKTAKE 664
             L Q+++      +EL+DEL+   +A+ +LE+ ++ +K Q  +  +T  E
Sbjct: 1537 -LEQQVEEMRTQLEELEDELQATEDAKLRLEVNMQAMKAQFERDLQTRDE 1585



 Score = 56.6 bits (135), Expect = 7e-08
 Identities = 59/264 (22%), Positives = 116/264 (43%), Gaps = 31/264 (11%)

Query: 399  VSQSKELTKTEASKSISRQSEKAHSSGKLQKTVSYPDVSLEEQEKMDLKTSRELCSRLDA 458
            +S+  E  KTE   ++   + +     K ++ V+    +LEE+ K      +++  R   
Sbjct: 1144 LSEELEALKTELEDTLDTTAAQQELRTKREQEVAELKKALEEETKNHEAQIQDMRQRHAT 1203

Query: 459  SISNNSTSKRKSESATCNLVRDINKVGIGLVAAASSPLLVKDVICEDDKGKIMEEVMRTY 518
            ++   S    +++    NL +  NK G+            K++ CE    K++++V    
Sbjct: 1204 ALEELSEQLEQAKRFKANLEK--NKQGLETDN--------KELACEV---KVLQQVKAES 1250

Query: 519  LKQQEKLNLILQKKQQLQMEVKMLSSSKSMKELTEEQQNLQKELESLQNEHAQRMEEFYV 578
              +++KL+  +Q     ++  K+    +   EL E+   LQ EL+++       +EE   
Sbjct: 1251 EHKRKKLDAQVQ-----ELHAKVSEGDRLRVELAEKASKLQNELDNVST----LLEE--- 1298

Query: 579  EQKDLEKKLEQIMKQKCTCDSNLEKDKEA--EYAGQLAELRQRLDHAEADRQELQDELRQ 636
                 EKK  +  K   + +S L+  +E   E   Q   L  R+   E ++  LQ++  +
Sbjct: 1299 ----AEKKGIKFAKDAASLESQLQDTQELLQEETRQKLNLSSRIRQLEEEKNSLQEQQEE 1354

Query: 637  EREARQKLEMMIKELKLQILKSSK 660
            E EAR+ LE  +  L+ Q+  + K
Sbjct: 1355 EEEARKNLEKQVLALQSQLADTKK 1378



 Score = 48.9 bits (115), Expect = 1e-05
 Identities = 70/336 (20%), Positives = 137/336 (40%), Gaps = 68/336 (20%)

Query: 387  KVVAPNVSLTSAVSQSKELTKTEASKSISRQSEKAHSSGKLQKTVSYPDVSLEEQEKMDL 446
            K V  ++    ++ ++K+    +A     R  EKA +  KL+KT +     L++   +DL
Sbjct: 1378 KKVDDDLGTIESLEEAKKKLLKDAEALSQRLEEKALAYDKLEKTKNRLQQELDDL-TVDL 1436

Query: 447  KTSRELCSRL-------------DASISNNSTSKRKSESATCNLVRDINKVGIGLVAAAS 493
               R++ S L             + SIS     +R    A     R+     + L  A  
Sbjct: 1437 DHQRQVASNLEKKQKKFDQLLAEEKSISARYAEERDRAEAE---AREKETKALSLARALE 1493

Query: 494  SPLLVKD----------------VICEDDKGKIMEEV-------------MRTYLKQ-QE 523
              L  K+                +  +DD GK + E+             MRT L++ ++
Sbjct: 1494 EALEAKEEFERQNKQLRADMEDLMSSKDDVGKNVHELEKSKRALEQQVEEMRTQLEELED 1553

Query: 524  KLNLILQKKQQLQMEVKMLSSSKSMKELTEEQQNLQK---------ELES-LQNEHAQR- 572
            +L      K +L++ ++ + +       T ++QN +K         ELE+ L++E  QR 
Sbjct: 1554 ELQATEDAKLRLEVNMQAMKAQFERDLQTRDEQNEEKKRLLIKQVRELEAELEDERKQRA 1613

Query: 573  -----MEEFYVEQKDLEKKLEQIMKQKCTCDSNLEKDKEAEYAGQLAELRQRLDHAEADR 627
                  ++  ++ KDLE ++E   K +      L K        Q+ + ++ L+ A A R
Sbjct: 1614 LAVASKKKMEIDLKDLEAQIEAANKARDEVIKQLRK-----LQAQMKDYQRELEEARASR 1668

Query: 628  QELQDELRQEREARQKLEMMIKELKLQILKSSKTAK 663
             E+  + ++  +  + LE  I +L+ ++  S +  +
Sbjct: 1669 DEIFAQSKESEKKLKSLEAEILQLQEELASSERARR 1704



 Score = 48.5 bits (114), Expect = 2e-05
 Identities = 40/181 (22%), Positives = 91/181 (50%), Gaps = 30/181 (16%)

Query: 511  MEEVMRTYLKQQEKLNLILQKKQQLQMEVKMLSSSKSMK-ELTEEQQNLQK---ELESLQ 566
            +EE+ R + +  E+ N++ +   QLQ E ++ + ++ M+  L  ++Q L++   +LES  
Sbjct: 875  LEEMERKHQQLLEEKNILAE---QLQAETELFAEAEEMRARLAAKKQELEEILHDLESRV 931

Query: 567  NEHAQRMEEFYVEQK-------DLEKKLEQ-------IMKQKCTCDSNLEK--------- 603
             E  +R +    E+K       DLE++L++       +  +K T ++ ++K         
Sbjct: 932  EEEEERNQILQNEKKKMQAHIQDLEEQLDEEEGARQKLQLEKVTAEAKIKKMEEEILLLE 991

Query: 604  DKEAEYAGQLAELRQRLDHAEADRQELQDELRQEREARQKLEMMIKELKLQILKSSKTAK 663
            D+ +++  +   +  R+    +   E +++ +   + R K E+MI +L+ ++ K  KT +
Sbjct: 992  DQNSKFIKEKKLMEDRIAECSSQLAEEEEKAKNLAKIRNKQEVMISDLEERLKKEEKTRQ 1051

Query: 664  E 664
            E
Sbjct: 1052 E 1052



 Score = 48.5 bits (114), Expect = 2e-05
 Identities = 69/356 (19%), Positives = 154/356 (43%), Gaps = 41/356 (11%)

Query: 320  EEKKLKII-----LEEMKEKFSMRSGKRNQSKTDAPSGMELQSWYPVIKQEGDHVSQTHS 374
            EE K K++     L +  E+ ++   K  ++K        LQ     +  + DH  Q  S
Sbjct: 1391 EEAKKKLLKDAEALSQRLEEKALAYDKLEKTKN------RLQQELDDLTVDLDHQRQVAS 1444

Query: 375  FLHPSYYLYMCDKVVAPNVSLTSAVSQSKELTKTEASKSISRQSEKAHSSGKLQKTVSYP 434
             L      +  D+++A   S+++  ++ ++  + EA +    +  KA S  +  +     
Sbjct: 1445 NLEKKQKKF--DQLLAEEKSISARYAEERDRAEAEARE----KETKALSLARALEEALEA 1498

Query: 435  DVSLEEQEKMDLKTSRELCSRLD---ASISNNSTSKRKSESATCNLVRDINKVGIGLVAA 491
                E Q K       +L S  D    ++     SKR  E     +   + ++   L A 
Sbjct: 1499 KEEFERQNKQLRADMEDLMSSKDDVGKNVHELEKSKRALEQQVEEMRTQLEELEDELQAT 1558

Query: 492  ASSPLLVKDVICEDDKGKIMEEVMRTYLKQQEKLNLILQKKQQLQMEVKMLSSSKSM--- 548
              + L + +V  +  K +   ++     + +EK  L++++ ++L+ E++     +++   
Sbjct: 1559 EDAKLRL-EVNMQAMKAQFERDLQTRDEQNEEKKRLLIKQVRELEAELEDERKQRALAVA 1617

Query: 549  --KELTEEQQNLQKELESL---QNEHAQRMEEFYVEQKDLEKKLEQIMKQKCTCDSNLEK 603
              K++  + ++L+ ++E+    ++E  +++ +   + KD +++LE+    +   D    +
Sbjct: 1618 SKKKMEIDLKDLEAQIEAANKARDEVIKQLRKLQAQMKDYQRELEEARASR---DEIFAQ 1674

Query: 604  DKEAEYAGQLAELRQRLDHAEADRQELQDELRQEREARQKLEMMIKELKLQILKSS 659
             KE+E         ++L   EA+  +LQ+EL     AR+  E    EL  +I  S+
Sbjct: 1675 SKESE---------KKLKSLEAEILQLQEELASSERARRHAEQERDELADEITNSA 1721



 Score = 47.8 bits (112), Expect = 3e-05
 Identities = 52/238 (21%), Positives = 107/238 (44%), Gaps = 25/238 (10%)

Query: 409  EASKSISRQSEKAHSSGKLQKTVSYPDVSLEEQEKMDLKTSRELCSRLDASISNNSTSKR 468
            E S  ++ + EKA +  K++         LEE+ K + KT +EL             +KR
Sbjct: 1010 ECSSQLAEEEEKAKNLAKIRNKQEVMISDLEERLKKEEKTRQEL-----------EKAKR 1058

Query: 469  KSESATCNLVRDINKVGIGLVAAASSPLLVKDVICEDDKGKIMEEVMRTYLKQQEKLNLI 528
            K +  T +L   I +     + A    L ++    E++    +       L +   L ++
Sbjct: 1059 KLDGETTDLQDQIAE-----LQAQIDELKLQLAKKEEELQGALARGDDETLHKNNALKVV 1113

Query: 529  LQKKQQLQMEVKMLSSSKSMKELTEEQ-QNLQKELESLQNEHAQRMEEFYVEQKDLEKKL 587
             + + Q+    +   S K+ +   E+Q ++L +ELE+L+ E    ++    +Q+   K+ 
Sbjct: 1114 RELQAQIAELQEDFESEKASRNKAEKQKRDLSEELEALKTELEDTLDTTAAQQELRTKRE 1173

Query: 588  EQIMKQKCTCDSNLEKDKEAEYAGQLAELRQRLDHAEADRQELQDELRQEREARQKLE 645
            +++ + K   +     ++   +  Q+ ++RQR  HA A  +EL ++L Q +  +  LE
Sbjct: 1174 QEVAELKKALE-----EETKNHEAQIQDMRQR--HATA-LEELSEQLEQAKRFKANLE 1223



 Score = 43.5 bits (101), Expect = 6e-04
 Identities = 41/168 (24%), Positives = 79/168 (47%), Gaps = 18/168 (10%)

Query: 509 KIMEEVMRTYLKQQE--------KLNLILQKKQQLQMEVKMLSSSKSMKELTEEQQNLQK 560
           K+++     YLK +         K+  +LQ  +Q   E ++ +  + + ++ E+Q  ++ 
Sbjct: 817 KVLQRNCAAYLKLRHWQWWRVFTKVKPLLQVTRQ---EEELQAKDEELLKVKEKQTKVEG 873

Query: 561 ELESLQNEHAQRMEEFYVEQKDLEKKLEQIMKQKCTCDSNLEKDKEAEYAGQLAELRQRL 620
           ELE ++ +H Q +EE  +  + L+ + E   + +        K +E E    L +L  R+
Sbjct: 874 ELEEMERKHQQLLEEKNILAEQLQAETELFAEAEEMRARLAAKKQELEEI--LHDLESRV 931

Query: 621 DHAEADRQELQDELRQEREARQKLEMMIKE-----LKLQILKSSKTAK 663
           +  E   Q LQ+E ++ +   Q LE  + E      KLQ+ K +  AK
Sbjct: 932 EEEEERNQILQNEKKKMQAHIQDLEEQLDEEEGARQKLQLEKVTAEAK 979



 Score = 42.0 bits (97), Expect = 0.002
 Identities = 58/262 (22%), Positives = 118/262 (45%), Gaps = 24/262 (9%)

Query: 404  ELTKTEASK---SISRQSEKAHSSGKLQKTVSYPDVSLEEQEKMDLKTSRELCSRLDASI 460
            EL  TE +K    ++ Q+ KA     LQ      D   EE++++ +K  REL + L+   
Sbjct: 1554 ELQATEDAKLRLEVNMQAMKAQFERDLQTR----DEQNEEKKRLLIKQVRELEAELEDER 1609

Query: 461  SNNS---TSKRKSESATCNLVRDI---NKVGIGLVAAASS-PLLVKDVICEDDKGKIMEE 513
               +    SK+K E    +L   I   NK    ++         +KD   E ++ +   +
Sbjct: 1610 KQRALAVASKKKMEIDLKDLEAQIEAANKARDEVIKQLRKLQAQMKDYQRELEEARASRD 1669

Query: 514  VMRTYLKQQEKLNLILQKKQQLQMEVKMLSSSKSMKELTEEQQNLQKELESLQNEHAQRM 573
             +    K+ EK  L   + + LQ++ ++ SS ++ +   +E+  L  E+ +  +  +  +
Sbjct: 1670 EIFAQSKESEK-KLKSLEAEILQLQEELASSERARRHAEQERDELADEITNSASGKSALL 1728

Query: 574  EEFYVEQKDLEKKLEQIMKQKCTCDSNLEKDKEAEYAGQLAELRQRLDHAEADRQELQDE 633
            +E    ++ LE ++ Q+ ++     SN+E   +     +  +   ++D   A+    +  
Sbjct: 1729 DE----KRRLEARIAQLEEELEEEQSNMELLND-----RFRKTTLQVDTLNAELAAERSA 1779

Query: 634  LRQEREARQKLEMMIKELKLQI 655
             ++   ARQ+LE   KELK ++
Sbjct: 1780 AQKSDNARQQLERQNKELKAKL 1801



 Score = 41.6 bits (96), Expect = 0.002
 Identities = 48/180 (26%), Positives = 89/180 (49%), Gaps = 31/180 (17%)

Query: 507  KGKIMEEVMR---TYLKQQEKLNLILQ-KKQQLQMEVKMLSSSKSMKELTEEQQNLQK-E 561
            K + +EE++    + ++++E+ N ILQ +K+++Q  ++ L      ++L EE+   QK +
Sbjct: 916  KKQELEEILHDLESRVEEEEERNQILQNEKKKMQAHIQDLE-----EQLDEEEGARQKLQ 970

Query: 562  LESLQNE-HAQRMEEFYVEQKDL------EKKLEQIMKQKCTCDSNLEKDKEAEYAG--- 611
            LE +  E   ++MEE  +  +D       EKKL +    +C+     E++K    A    
Sbjct: 971  LEKVTAEAKIKKMEEEILLLEDQNSKFIKEKKLMEDRIAECSSQLAEEEEKAKNLAKIRN 1030

Query: 612  ----QLAELRQRLDHAEADRQELQ-------DELRQEREARQKLEMMIKELKLQILKSSK 660
                 +++L +RL   E  RQEL+        E    ++   +L+  I ELKLQ+ K  +
Sbjct: 1031 KQEVMISDLEERLKKEEKTRQELEKAKRKLDGETTDLQDQIAELQAQIDELKLQLAKKEE 1090



 Score = 41.2 bits (95), Expect = 0.003
 Identities = 40/159 (25%), Positives = 81/159 (50%), Gaps = 21/159 (13%)

Query: 520  KQQEKLN-----LILQKKQQLQMEVKMLSSSKSMKELTEEQQNLQKELESLQNEHAQRME 574
            +Q+E+L      L+  K++Q ++E ++    +  ++L EE+  L ++L++ + E     E
Sbjct: 849  RQEEELQAKDEELLKVKEKQTKVEGELEEMERKHQQLLEEKNILAEQLQA-ETELFAEAE 907

Query: 575  EFYVEQKDLEKKLEQIMKQKCTCDSNLEKDKEAEYAGQ---------LAELRQRLDHAEA 625
            E        +++LE+I+      +S +E+++E     Q         + +L ++LD  E 
Sbjct: 908  EMRARLAAKKQELEEILHD---LESRVEEEEERNQILQNEKKKMQAHIQDLEEQLDEEEG 964

Query: 626  DRQELQDELRQEREARQKLEMMIKELKLQILKSSKTAKE 664
             RQ+LQ E   +  A  K++ M +E+ L   ++SK  KE
Sbjct: 965  ARQKLQLE---KVTAEAKIKKMEEEILLLEDQNSKFIKE 1000


>gi|50897852 coiled-coil domain containing 88A isoform 2 [Homo
           sapiens]
          Length = 1843

 Score = 58.5 bits (140), Expect = 2e-08
 Identities = 73/325 (22%), Positives = 139/325 (42%), Gaps = 66/325 (20%)

Query: 386 DKVVAPNVSLTSAVSQSKELTKTEASKSISRQSEKAHSSGKLQKTVSYPDVSLEEQEKMD 445
           +++V    SL +  + SK+L K +A               +L+KT+     +L E  +  
Sbjct: 512 NEIVQEKQSLQNCQNLSKDLMKEKA---------------QLEKTIE----TLRENSERQ 552

Query: 446 LKTSRELCSRLDASISNNSTSKRKSESATCNLVRDINKVGIGLVAAASSPL--------- 496
           +K   +    L+ ++S+     + S  A    +   NK+    +   SS L         
Sbjct: 553 IKILEQENEHLNQTVSSLRQRSQISAEARVKDIEKENKILHESIKETSSKLSKIEFEKRQ 612

Query: 497 LVKDVICEDDKGKIMEEVMRTYLKQQEKLNLILQKK-----------QQLQMEVKMLS-S 544
           + K++    +KG+  EE +   L   EK N +LQKK           + L+ E   L   
Sbjct: 613 IKKELEHYKEKGERAEE-LENELHHLEKENELLQKKITNLKITCEKIEALEQENSELERE 671

Query: 545 SKSMKELTEEQQNLQKELESLQNEHAQ--------------------RMEEFYVEQKDLE 584
           ++ +K+  +  +NL  +LESL+ E++Q                    +M +  +E K+LE
Sbjct: 672 NRKLKKTLDSFKNLTFQLESLEKENSQLDEENLELRRNVESLKCASMKMAQLQLENKELE 731

Query: 585 KKLEQIMKQKCTCDSNLEKDK--EAEYAG---QLAELRQRLDHAEADRQELQDELRQERE 639
            + EQ+ K      ++ +K +  E  Y G   +   L++ L+++    Q+L+ EL+    
Sbjct: 732 SEKEQLKKGLELLKASFKKTERLEVSYQGLDIENQRLQKTLENSNKKIQQLESELQDLEM 791

Query: 640 ARQKLEMMIKELKLQILKSSKTAKE 664
             Q L+  ++ELK+   +  +  KE
Sbjct: 792 ENQTLQKNLEELKISSKRLEQLEKE 816



 Score = 38.9 bits (89), Expect = 0.015
 Identities = 55/270 (20%), Positives = 116/270 (42%), Gaps = 44/270 (16%)

Query: 401 QSKELTKTEASKSISRQSEKAHSSGKLQKTVSYPDVSLEEQEKMDLKTSRELCSRLDASI 460
           + K +   +    +SR  E+ H     +  V      L+E  ++ L+T   L  +L+ + 
Sbjct: 316 REKAVRVDKLESEVSRYKERLHDIEFYKARVE----ELKEDNQVLLETKTMLEDQLEGT- 370

Query: 461 SNNSTSKRKSESATCNLVRDINKVGIGLVAAASSPLLVKDVICEDDKGKI---MEEVMRT 517
                       A  + + ++ K  + L A      + +D+    D+ KI   MEE M  
Sbjct: 371 -----------RARSDKLHELEKENLQLKAKLHDMEMERDM----DRKKIEELMEENMTL 415

Query: 518 YLKQQEKLNLILQKKQQLQMEVKMLSSSKSMKELTEEQQNLQKELESLQNEHAQRMEEFY 577
            + Q++ ++  L     L  E++ +S +  + E    Q++L  E+  L +    ++E   
Sbjct: 416 EMAQKQSMDESLH----LGWELEQISRTSELSEAP--QKSLGHEVNELTSSRLLKLE--- 466

Query: 578 VEQKDLEKKLEQIMKQKCTCDSNLEKDKEAEYAGQLAELRQRLDHAEADRQELQDELRQE 637
           +E + L K +E++     + + N  K  + E   Q    +  +         L++E+ QE
Sbjct: 467 MENQSLTKTVEELRTTVDSVEGNASKILKMEKENQRLSKKVEI---------LENEIVQE 517

Query: 638 REARQKLEMMIKEL---KLQILKSSKTAKE 664
           +++ Q  + + K+L   K Q+ K+ +T +E
Sbjct: 518 KQSLQNCQNLSKDLMKEKAQLEKTIETLRE 547



 Score = 37.0 bits (84), Expect = 0.058
 Identities = 57/266 (21%), Positives = 115/266 (43%), Gaps = 28/266 (10%)

Query: 407 KTEASKSISRQSEKA-------HSSGKLQKTVSYPDVSLEEQ------EKMDLKTS-REL 452
           + E S++I   SE+        H+S   Q     P +   E       E  D K   R L
Sbjct: 204 RDEHSETIIELSEERDGLHFLPHASSSAQSPCGSPGMKRTESRQHLSVELADAKAKIRRL 263

Query: 453 CSRLDASISNNSTSKRKSESATCNLVRDINKVGIGLVAAASSPLLVKDVI-CEDDKG--- 508
              L+         K++ E     L R + +  + L++ A S  + +D +    +K    
Sbjct: 264 RQELEEKTEQLLDCKQELEQMEIELKR-LQQENMNLLSDARSARMYRDELDALREKAVRV 322

Query: 509 -KIMEEVMRTYLKQQEKLNLILQKKQQLQMEVKMLSSSKSMKELTEEQQNLQKE-LESLQ 566
            K+  EV R Y ++   +     + ++L+ + ++L  +K+M E   E    + + L  L+
Sbjct: 323 DKLESEVSR-YKERLHDIEFYKARVEELKEDNQVLLETKTMLEDQLEGTRARSDKLHELE 381

Query: 567 NEHAQ---RMEEFYVEQKDLEKKLEQIMKQKCTCD--SNLEKDKEAEYAGQLAELRQRLD 621
            E+ Q   ++ +  +E+    KK+E++M++  T +       D+      +L ++ +  +
Sbjct: 382 KENLQLKAKLHDMEMERDMDRKKIEELMEENMTLEMAQKQSMDESLHLGWELEQISRTSE 441

Query: 622 HAEADRQELQDELRQEREAR-QKLEM 646
            +EA ++ L  E+ +   +R  KLEM
Sbjct: 442 LSEAPQKSLGHEVNELTSSRLLKLEM 467



 Score = 37.0 bits (84), Expect = 0.058
 Identities = 77/366 (21%), Positives = 151/366 (41%), Gaps = 52/366 (14%)

Query: 321 EKKLKIILEEMKE---KFSMRSGKRNQSKTDAPSGMELQSWYPVIKQEGDHVSQTHSFLH 377
           EK+ KI+ E +KE   K S    ++ Q K +     E       ++ E  H+ + +  L 
Sbjct: 586 EKENKILHESIKETSSKLSKIEFEKRQIKKELEHYKEKGERAEELENELHHLEKENELLQ 645

Query: 378 PSY--YLYMCDKVVAPNVSLTSAVSQSKELTKT-EASKSISRQSEKAHSSGKLQKTVSYP 434
                    C+K+ A     +    ++++L KT ++ K+++ Q E       L+K  S  
Sbjct: 646 KKITNLKITCEKIEALEQENSELERENRKLKKTLDSFKNLTFQLES------LEKENSQL 699

Query: 435 DVSLEEQEKMDLKTSRELCSRLDASISNNSTSKRKSESATCNLVRDINKVGIGLVAAASS 494
           D     +E ++L+ + E        ++      ++ ES    L     K G+ L+ A+  
Sbjct: 700 D-----EENLELRRNVESLKCASMKMAQLQLENKELESEKEQL-----KKGLELLKASFK 749

Query: 495 PLLVKDV--------------ICEDDKGKI---------MEEVMRTYLKQQEKLNLILQK 531
                +V                E+   KI         +E   +T  K  E+L +  ++
Sbjct: 750 KTERLEVSYQGLDIENQRLQKTLENSNKKIQQLESELQDLEMENQTLQKNLEELKISSKR 809

Query: 532 KQQLQMEVKMLSSSKSMKELTEEQQNLQKELESLQNEHAQR---MEEFYVEQKDLEKKLE 588
            +QL+ E K L    S  +L ++++ L+KE + L+ +   +   +EE  V+  +LEK+ +
Sbjct: 810 LEQLEKENKSLEQETS--QLEKDKKQLEKENKRLRQQAEIKDTTLEENNVKIGNLEKENK 867

Query: 589 QIMKQKCTCDSNLEKDKEAEYAGQLAELRQRLD--HAEADRQELQDELRQEREARQKLEM 646
            + K+      +  + KE E   +    R  +D       R++L  E  + ++    LE 
Sbjct: 868 TLSKEIGIYKESCVRLKELEKENKELVKRATIDIKTLVTLREDLVSEKLKTQQMNNDLEK 927

Query: 647 MIKELK 652
           +  EL+
Sbjct: 928 LTHELE 933



 Score = 35.8 bits (81), Expect = 0.13
 Identities = 65/327 (19%), Positives = 129/327 (39%), Gaps = 63/327 (19%)

Query: 386  DKVVAPNVSLTSAVSQSKELTKTEASKSISRQSEKAHSSGKLQKTV-SYPDVSLEEQ--E 442
            +K+ A    L  + + +++L   +  K++ +  E        ++ V S P +S E+   E
Sbjct: 974  EKIAALEARLEESTNYNQQLR--QELKTVKKNYEALKQRQDEERMVQSSPPISGEDNKWE 1031

Query: 443  KMDLKTSRELCSRLDASIS---NNSTSKRKSESATCNL-------------VRDINKVGI 486
            +   +T+REL    D  I    NN+T + + ++    L             +  + +  +
Sbjct: 1032 RESQETTRELLKVKDRLIEVERNNATLQAEKQALKTQLKQLETQNNNLQAQILALQRQTV 1091

Query: 487  GL------VAAASSPLLVKDVICEDDKGKIMEEVMRTYLKQQEKLN---LILQKKQQLQM 537
             L      +   ++ L V++         +M +  +  ++Q    N    ++++++ L+ 
Sbjct: 1092 SLQEQNTTLQTQNAKLQVENSTLNSQSTSLMNQNAQLLIQQSSLENENESVIKEREDLKS 1151

Query: 538  EVKMLSSSKSMKELTEEQQNLQKELESLQNEHA---QRMEEFYVEQKDLEKKLEQIMKQK 594
                L       EL  E+Q    E ESL ++H       +   VE +DLE +  Q++KQK
Sbjct: 1152 LYDSLIKDHEKLELLHERQ--ASEYESLISKHGTLKSAHKNLEVEHRDLEDRYNQLLKQK 1209

Query: 595  CTCDSNLEKDKEAEYAGQLAELR----------------QRLDHA-----------EADR 627
               + +LEK  + E    L E +                 RL+H            + D 
Sbjct: 1210 GQLE-DLEKMLKVEQEKMLLENKNHETVAAEYKKLCGENDRLNHTYSQLLKETEVLQTDH 1268

Query: 628  QELQDELRQEREARQKLEMMIKELKLQ 654
            + L+  L   +  + +LE    +LK Q
Sbjct: 1269 KNLKSLLNNSKLEQTRLEAEFSKLKEQ 1295



 Score = 30.4 bits (67), Expect = 5.5
 Identities = 57/272 (20%), Positives = 114/272 (41%), Gaps = 42/272 (15%)

Query: 404 ELTKTEASKSISRQSEKAHSSGKLQKTVSYPDVS---LEE--QEKMDL----KTSRELCS 454
           E T+  + K    + E      KL       D+    +EE  +E M L    K S +   
Sbjct: 368 EGTRARSDKLHELEKENLQLKAKLHDMEMERDMDRKKIEELMEENMTLEMAQKQSMDESL 427

Query: 455 RLDASISNNSTSKRKSESATCNLVRDINKVGIGLVAAASSPLLVKDVICEDDKGKIMEEV 514
            L   +   S +   SE+   +L  ++N++        +S  L+K  +      K +EE+
Sbjct: 428 HLGWELEQISRTSELSEAPQKSLGHEVNEL--------TSSRLLKLEMENQSLTKTVEEL 479

Query: 515 MRTYLKQQEKLNLILQ---KKQQLQMEVKMLSSSKSMKELTEEQQNLQKELESLQNEHAQ 571
             T    +   + IL+   + Q+L  +V++L +     E+ +E+Q+L    ++ QN    
Sbjct: 480 RTTVDSVEGNASKILKMEKENQRLSKKVEILEN-----EIVQEKQSL----QNCQNLSKD 530

Query: 572 RMEEFYVEQKDLEKKLEQIMKQKCTCDSNLEKDKEAEYAGQLAELRQ--------RLDHA 623
            M+    E+  LEK +E + +        LE++ E      ++ LRQ        R+   
Sbjct: 531 LMK----EKAQLEKTIETLRENSERQIKILEQENE-HLNQTVSSLRQRSQISAEARVKDI 585

Query: 624 EADRQELQDELRQEREARQKLEMMIKELKLQI 655
           E + + L + +++      K+E   +++K ++
Sbjct: 586 EKENKILHESIKETSSKLSKIEFEKRQIKKEL 617



 Score = 29.6 bits (65), Expect = 9.3
 Identities = 29/128 (22%), Positives = 59/128 (46%), Gaps = 11/128 (8%)

Query: 544 SSKSMKELTEEQQNLQKELESLQNEHAQRMEEFYVEQKDLEKKLEQIMKQKCTCDSNLEK 603
           S + ++ L +      K L   ++EH++ + E   E+  L          +  C S   K
Sbjct: 182 SQEDIEPLLKNMALHLKRLIDERDEHSETIIELSEERDGLHFLPHASSSAQSPCGSPGMK 241

Query: 604 DKEAEY--AGQLAELRQRLDHAEADRQELQDELRQEREARQKLEMMIKELK------LQI 655
             E+    + +LA+ + ++      RQEL+++  Q  + +Q+LE M  ELK      + +
Sbjct: 242 RTESRQHLSVELADAKAKIRRL---RQELEEKTEQLLDCKQELEQMEIELKRLQQENMNL 298

Query: 656 LKSSKTAK 663
           L  +++A+
Sbjct: 299 LSDARSAR 306


>gi|208022632 coiled-coil domain containing 88A isoform 1 [Homo
           sapiens]
          Length = 1870

 Score = 58.5 bits (140), Expect = 2e-08
 Identities = 73/325 (22%), Positives = 139/325 (42%), Gaps = 66/325 (20%)

Query: 386 DKVVAPNVSLTSAVSQSKELTKTEASKSISRQSEKAHSSGKLQKTVSYPDVSLEEQEKMD 445
           +++V    SL +  + SK+L K +A               +L+KT+     +L E  +  
Sbjct: 512 NEIVQEKQSLQNCQNLSKDLMKEKA---------------QLEKTIE----TLRENSERQ 552

Query: 446 LKTSRELCSRLDASISNNSTSKRKSESATCNLVRDINKVGIGLVAAASSPL--------- 496
           +K   +    L+ ++S+     + S  A    +   NK+    +   SS L         
Sbjct: 553 IKILEQENEHLNQTVSSLRQRSQISAEARVKDIEKENKILHESIKETSSKLSKIEFEKRQ 612

Query: 497 LVKDVICEDDKGKIMEEVMRTYLKQQEKLNLILQKK-----------QQLQMEVKMLS-S 544
           + K++    +KG+  EE +   L   EK N +LQKK           + L+ E   L   
Sbjct: 613 IKKELEHYKEKGERAEE-LENELHHLEKENELLQKKITNLKITCEKIEALEQENSELERE 671

Query: 545 SKSMKELTEEQQNLQKELESLQNEHAQ--------------------RMEEFYVEQKDLE 584
           ++ +K+  +  +NL  +LESL+ E++Q                    +M +  +E K+LE
Sbjct: 672 NRKLKKTLDSFKNLTFQLESLEKENSQLDEENLELRRNVESLKCASMKMAQLQLENKELE 731

Query: 585 KKLEQIMKQKCTCDSNLEKDK--EAEYAG---QLAELRQRLDHAEADRQELQDELRQERE 639
            + EQ+ K      ++ +K +  E  Y G   +   L++ L+++    Q+L+ EL+    
Sbjct: 732 SEKEQLKKGLELLKASFKKTERLEVSYQGLDIENQRLQKTLENSNKKIQQLESELQDLEM 791

Query: 640 ARQKLEMMIKELKLQILKSSKTAKE 664
             Q L+  ++ELK+   +  +  KE
Sbjct: 792 ENQTLQKNLEELKISSKRLEQLEKE 816



 Score = 47.4 bits (111), Expect = 4e-05
 Identities = 86/395 (21%), Positives = 158/395 (40%), Gaps = 57/395 (14%)

Query: 321 EKKLKIILEEMKE---KFSMRSGKRNQSKTDAPSGMELQSWYPVIKQEGDHVSQTHSFLH 377
           EK+ KI+ E +KE   K S    ++ Q K +     E       ++ E  H+ + +  L 
Sbjct: 586 EKENKILHESIKETSSKLSKIEFEKRQIKKELEHYKEKGERAEELENELHHLEKENELLQ 645

Query: 378 PSY--YLYMCDKVVAPNVSLTSAVSQSKELTKT-EASKSISRQSEKAHSSG--------K 426
                    C+K+ A     +    ++++L KT ++ K+++ Q E              +
Sbjct: 646 KKITNLKITCEKIEALEQENSELERENRKLKKTLDSFKNLTFQLESLEKENSQLDEENLE 705

Query: 427 LQKTVS--------YPDVSLE----EQEKMDLKTSRELCS-------RLDASISNNSTSK 467
           L++ V            + LE    E EK  LK   EL         RL+ S        
Sbjct: 706 LRRNVESLKCASMKMAQLQLENKELESEKEQLKKGLELLKASFKKTERLEVSYQGLDIEN 765

Query: 468 RKSESATCNLVRDINKVGIGLV-AAASSPLLVKDVICEDDKGKIMEEVMRTYLKQQEKLN 526
           ++ +    N  + I ++   L      +  L K++       K +E++ +     +++ +
Sbjct: 766 QRLQKTLENSNKKIQQLESELQDLEMENQTLQKNLEELKISSKRLEQLEKENKSLEQETS 825

Query: 527 LILQKKQQLQMEVKMLSSSKSMKELTEEQQN-----LQKELESLQNE------HAQRMEE 575
            + + K+QL+ E K L     +K+ T E+ N     L+KE ++L  E         R++E
Sbjct: 826 QLEKDKKQLEKENKRLRQQAEIKDTTLEENNVKIGNLEKENKTLSKEIGIYKESCVRLKE 885

Query: 576 FYVEQKDLEKKLEQIMKQKCTCDSNL--EKDKEAEYAGQLAEL----------RQRLDHA 623
              E K+L K+    +K   T   +L  EK K  +    L +L          ++RL H 
Sbjct: 886 LEKENKELVKRATIDIKTLVTLREDLVSEKLKTQQMNNDLEKLTHELEKIGLNKERLLHD 945

Query: 624 EADRQELQDELRQEREARQKLEMMIKELKLQILKS 658
           E    +    L  + E+  K  + IKE K+  L++
Sbjct: 946 EQSTDDRYKLLESKLESTLKKSLEIKEEKIAALEA 980



 Score = 38.9 bits (89), Expect = 0.015
 Identities = 55/270 (20%), Positives = 116/270 (42%), Gaps = 44/270 (16%)

Query: 401 QSKELTKTEASKSISRQSEKAHSSGKLQKTVSYPDVSLEEQEKMDLKTSRELCSRLDASI 460
           + K +   +    +SR  E+ H     +  V      L+E  ++ L+T   L  +L+ + 
Sbjct: 316 REKAVRVDKLESEVSRYKERLHDIEFYKARVE----ELKEDNQVLLETKTMLEDQLEGT- 370

Query: 461 SNNSTSKRKSESATCNLVRDINKVGIGLVAAASSPLLVKDVICEDDKGKI---MEEVMRT 517
                       A  + + ++ K  + L A      + +D+    D+ KI   MEE M  
Sbjct: 371 -----------RARSDKLHELEKENLQLKAKLHDMEMERDM----DRKKIEELMEENMTL 415

Query: 518 YLKQQEKLNLILQKKQQLQMEVKMLSSSKSMKELTEEQQNLQKELESLQNEHAQRMEEFY 577
            + Q++ ++  L     L  E++ +S +  + E    Q++L  E+  L +    ++E   
Sbjct: 416 EMAQKQSMDESLH----LGWELEQISRTSELSEAP--QKSLGHEVNELTSSRLLKLE--- 466

Query: 578 VEQKDLEKKLEQIMKQKCTCDSNLEKDKEAEYAGQLAELRQRLDHAEADRQELQDELRQE 637
           +E + L K +E++     + + N  K  + E   Q    +  +         L++E+ QE
Sbjct: 467 MENQSLTKTVEELRTTVDSVEGNASKILKMEKENQRLSKKVEI---------LENEIVQE 517

Query: 638 REARQKLEMMIKEL---KLQILKSSKTAKE 664
           +++ Q  + + K+L   K Q+ K+ +T +E
Sbjct: 518 KQSLQNCQNLSKDLMKEKAQLEKTIETLRE 547



 Score = 37.0 bits (84), Expect = 0.058
 Identities = 57/266 (21%), Positives = 115/266 (43%), Gaps = 28/266 (10%)

Query: 407 KTEASKSISRQSEKA-------HSSGKLQKTVSYPDVSLEEQ------EKMDLKTS-REL 452
           + E S++I   SE+        H+S   Q     P +   E       E  D K   R L
Sbjct: 204 RDEHSETIIELSEERDGLHFLPHASSSAQSPCGSPGMKRTESRQHLSVELADAKAKIRRL 263

Query: 453 CSRLDASISNNSTSKRKSESATCNLVRDINKVGIGLVAAASSPLLVKDVI-CEDDKG--- 508
              L+         K++ E     L R + +  + L++ A S  + +D +    +K    
Sbjct: 264 RQELEEKTEQLLDCKQELEQMEIELKR-LQQENMNLLSDARSARMYRDELDALREKAVRV 322

Query: 509 -KIMEEVMRTYLKQQEKLNLILQKKQQLQMEVKMLSSSKSMKELTEEQQNLQKE-LESLQ 566
            K+  EV R Y ++   +     + ++L+ + ++L  +K+M E   E    + + L  L+
Sbjct: 323 DKLESEVSR-YKERLHDIEFYKARVEELKEDNQVLLETKTMLEDQLEGTRARSDKLHELE 381

Query: 567 NEHAQ---RMEEFYVEQKDLEKKLEQIMKQKCTCD--SNLEKDKEAEYAGQLAELRQRLD 621
            E+ Q   ++ +  +E+    KK+E++M++  T +       D+      +L ++ +  +
Sbjct: 382 KENLQLKAKLHDMEMERDMDRKKIEELMEENMTLEMAQKQSMDESLHLGWELEQISRTSE 441

Query: 622 HAEADRQELQDELRQEREAR-QKLEM 646
            +EA ++ L  E+ +   +R  KLEM
Sbjct: 442 LSEAPQKSLGHEVNELTSSRLLKLEM 467



 Score = 35.8 bits (81), Expect = 0.13
 Identities = 65/327 (19%), Positives = 129/327 (39%), Gaps = 63/327 (19%)

Query: 386  DKVVAPNVSLTSAVSQSKELTKTEASKSISRQSEKAHSSGKLQKTV-SYPDVSLEEQ--E 442
            +K+ A    L  + + +++L   +  K++ +  E        ++ V S P +S E+   E
Sbjct: 973  EKIAALEARLEESTNYNQQLR--QELKTVKKNYEALKQRQDEERMVQSSPPISGEDNKWE 1030

Query: 443  KMDLKTSRELCSRLDASIS---NNSTSKRKSESATCNL-------------VRDINKVGI 486
            +   +T+REL    D  I    NN+T + + ++    L             +  + +  +
Sbjct: 1031 RESQETTRELLKVKDRLIEVERNNATLQAEKQALKTQLKQLETQNNNLQAQILALQRQTV 1090

Query: 487  GL------VAAASSPLLVKDVICEDDKGKIMEEVMRTYLKQQEKLN---LILQKKQQLQM 537
             L      +   ++ L V++         +M +  +  ++Q    N    ++++++ L+ 
Sbjct: 1091 SLQEQNTTLQTQNAKLQVENSTLNSQSTSLMNQNAQLLIQQSSLENENESVIKEREDLKS 1150

Query: 538  EVKMLSSSKSMKELTEEQQNLQKELESLQNEHA---QRMEEFYVEQKDLEKKLEQIMKQK 594
                L       EL  E+Q    E ESL ++H       +   VE +DLE +  Q++KQK
Sbjct: 1151 LYDSLIKDHEKLELLHERQ--ASEYESLISKHGTLKSAHKNLEVEHRDLEDRYNQLLKQK 1208

Query: 595  CTCDSNLEKDKEAEYAGQLAELR----------------QRLDHA-----------EADR 627
               + +LEK  + E    L E +                 RL+H            + D 
Sbjct: 1209 GQLE-DLEKMLKVEQEKMLLENKNHETVAAEYKKLCGENDRLNHTYSQLLKETEVLQTDH 1267

Query: 628  QELQDELRQEREARQKLEMMIKELKLQ 654
            + L+  L   +  + +LE    +LK Q
Sbjct: 1268 KNLKSLLNNSKLEQTRLEAEFSKLKEQ 1294



 Score = 30.4 bits (67), Expect = 5.5
 Identities = 57/272 (20%), Positives = 114/272 (41%), Gaps = 42/272 (15%)

Query: 404 ELTKTEASKSISRQSEKAHSSGKLQKTVSYPDVS---LEE--QEKMDL----KTSRELCS 454
           E T+  + K    + E      KL       D+    +EE  +E M L    K S +   
Sbjct: 368 EGTRARSDKLHELEKENLQLKAKLHDMEMERDMDRKKIEELMEENMTLEMAQKQSMDESL 427

Query: 455 RLDASISNNSTSKRKSESATCNLVRDINKVGIGLVAAASSPLLVKDVICEDDKGKIMEEV 514
            L   +   S +   SE+   +L  ++N++        +S  L+K  +      K +EE+
Sbjct: 428 HLGWELEQISRTSELSEAPQKSLGHEVNEL--------TSSRLLKLEMENQSLTKTVEEL 479

Query: 515 MRTYLKQQEKLNLILQ---KKQQLQMEVKMLSSSKSMKELTEEQQNLQKELESLQNEHAQ 571
             T    +   + IL+   + Q+L  +V++L +     E+ +E+Q+L    ++ QN    
Sbjct: 480 RTTVDSVEGNASKILKMEKENQRLSKKVEILEN-----EIVQEKQSL----QNCQNLSKD 530

Query: 572 RMEEFYVEQKDLEKKLEQIMKQKCTCDSNLEKDKEAEYAGQLAELRQ--------RLDHA 623
            M+    E+  LEK +E + +        LE++ E      ++ LRQ        R+   
Sbjct: 531 LMK----EKAQLEKTIETLRENSERQIKILEQENE-HLNQTVSSLRQRSQISAEARVKDI 585

Query: 624 EADRQELQDELRQEREARQKLEMMIKELKLQI 655
           E + + L + +++      K+E   +++K ++
Sbjct: 586 EKENKILHESIKETSSKLSKIEFEKRQIKKEL 617



 Score = 29.6 bits (65), Expect = 9.3
 Identities = 29/128 (22%), Positives = 59/128 (46%), Gaps = 11/128 (8%)

Query: 544 SSKSMKELTEEQQNLQKELESLQNEHAQRMEEFYVEQKDLEKKLEQIMKQKCTCDSNLEK 603
           S + ++ L +      K L   ++EH++ + E   E+  L          +  C S   K
Sbjct: 182 SQEDIEPLLKNMALHLKRLIDERDEHSETIIELSEERDGLHFLPHASSSAQSPCGSPGMK 241

Query: 604 DKEAEY--AGQLAELRQRLDHAEADRQELQDELRQEREARQKLEMMIKELK------LQI 655
             E+    + +LA+ + ++      RQEL+++  Q  + +Q+LE M  ELK      + +
Sbjct: 242 RTESRQHLSVELADAKAKIRRL---RQELEEKTEQLLDCKQELEQMEIELKRLQQENMNL 298

Query: 656 LKSSKTAK 663
           L  +++A+
Sbjct: 299 LSDARSAR 306


>gi|41322923 plectin 1 isoform 11 [Homo sapiens]
          Length = 4547

 Score = 56.6 bits (135), Expect = 7e-08
 Identities = 59/270 (21%), Positives = 123/270 (45%), Gaps = 29/270 (10%)

Query: 399  VSQSKELTKTEASKSISRQSEKAHSSGKLQKTVSYPDVSLEEQEKMDLKTSRELCSRLDA 458
            + Q KEL + +A +    Q +K   + +L +       +LE + +  L+ S E   RL  
Sbjct: 2332 LQQQKELAQEQARRL---QEDKEQMAQQLAEETQGFQRTLEAERQRQLEMSAE-AERLKL 2387

Query: 459  SISNNSTSKRKSESATCNLVRDINKVGIGL----VAAASSPLLVKDVICEDDKGKIMEEV 514
             ++  S ++ ++E       +   ++G  L    +A      LV+ +  +  +     E 
Sbjct: 2388 RVAEMSRAQARAEEDAQRFRKQAEEIGEKLHRTELATQEKVTLVQTLEIQRQQSDHDAER 2447

Query: 515  MRTYLKQQEKLNLILQKKQQLQMEVKMLSSSKSMKELTEEQQNLQKELESLQNEHAQRME 574
            +R  + + E+      +K++LQ E K+L   KS +  T +Q+ L +E ++LQ       +
Sbjct: 2448 LREAIAELER------EKEKLQQEAKLLQL-KSEEMQTVQQEQLLQETQALQQSFLSEKD 2500

Query: 575  EFYVEQKDLEK---KLEQIMKQKCTCDSNLEKDKEAEY----------AGQLAELRQRLD 621
                 ++ +E+   KLEQ+ + +      L ++++ +              + E R+R  
Sbjct: 2501 SLLQRERFIEQEKAKLEQLFQDEVAKAQQLREEQQRQQQQMEQERQRLVASMEEARRRQH 2560

Query: 622  HAEADRQELQDELRQ-EREARQKLEMMIKE 650
             AE   +  Q+EL+Q E++ RQ+ E++ +E
Sbjct: 2561 EAEEGVRRKQEELQQLEQQRRQQEELLAEE 2590



 Score = 52.4 bits (124), Expect = 1e-06
 Identities = 68/284 (23%), Positives = 126/284 (44%), Gaps = 34/284 (11%)

Query: 400  SQSKELTKTEASKSISRQSEKAHSSGKLQKTVSYPDVSLEEQEKM----DLKTSRELCSR 455
            SQ K   + E +  +  ++E A    +  + +    +  EE E+     +++ +R++   
Sbjct: 1507 SQRKRQAEVELASRVKAEAEAAREKQRALQALEELRLQAEEAERRLRQAEVERARQVQVA 1566

Query: 456  LDA---SISNNSTSKRKS-ESATCNLVRDINK--VGIGLVAAASSPLLVKDVICEDDKGK 509
            L+    S      SKR S    T  L R + +  V +  +   +     +    E  + +
Sbjct: 1567 LETAQRSAEAELQSKRASFAEKTAQLERSLQEEHVAVAQLREEAERRAQQQAEAERAREE 1626

Query: 510  IMEEVMRTYLKQQEKLNLILQKKQQLQMEVKMLSSSKSMKELTEEQQNLQKELESLQNEH 569
               E+ R  LK  E L L LQ ++  Q         KS+ +   E+Q  + E E+ +   
Sbjct: 1627 AERELERWQLKANEALRLRLQAEEVAQQ--------KSLAQAEAEKQKEEAEREARRRGK 1678

Query: 570  AQRMEEFYVEQKDLEKKLEQIMKQKCTCDSNLEKDKEAEYAGQLAELRQRLDHAEADRQE 629
            A   EE  V Q++L +  +++ KQ+   +   ++   AE   +L  LR   +  E  RQ 
Sbjct: 1679 A---EEQAVRQRELAE--QELEKQRQLAEGTAQQRLAAEQ--ELIRLRAETEQGEQQRQL 1731

Query: 630  LQDEL-RQEREA------RQKLEMMIKELK--LQILKSSKTAKE 664
            L++EL R +REA      RQ+LE  + +++  +++L +SK   E
Sbjct: 1732 LEEELARLQREAAAATQKRQELEAELAKVRAEMEVLLASKARAE 1775



 Score = 44.3 bits (103), Expect = 4e-04
 Identities = 65/296 (21%), Positives = 123/296 (41%), Gaps = 43/296 (14%)

Query: 401  QSKELTKTEASKSISRQSEKAHSSGK---------LQKTVSYPDVSLEE------QEKMD 445
            + + L + EA+    RQ  +AH+  K         LQ+ +    V  EE      Q+K  
Sbjct: 1358 ERERLAEVEAALEKQRQLAEAHAQAKAQAEREAKELQQRMQEEVVRREEAAVDAQQQKRS 1417

Query: 446  LKTS-RELCSRLDASISNNSTSKRKSESATCNLVRDINKVGIGLVAAAS---------SP 495
            ++   ++L    +A I   +     +E +   +  +I  V + L A              
Sbjct: 1418 IQEELQQLRQSSEAEIQAKARQAEAAERSRLRIEEEIRVVRLQLEATERQRGGAEGELQA 1477

Query: 496  LLVKDVICEDDKGKIMEEVMRTYLKQQEKLNLILQKKQQLQMEVKMLSSSKSMKELTEEQ 555
            L  +    E  K +  EE  R   + Q+      + +++ Q EV++ S  K+  E   E+
Sbjct: 1478 LRARAEEAEAQKRQAQEEAERLRRQVQD------ESQRKRQAEVELASRVKAEAEAAREK 1531

Query: 556  QNLQKELES--LQNEHAQRMEEFYVEQKDLEKKLE-QIMKQKCTCDSNLE-KDKEAEYAG 611
            Q   + LE   LQ E A+R     + Q ++E+  + Q+  +     +  E + K A +A 
Sbjct: 1532 QRALQALEELRLQAEEAERR----LRQAEVERARQVQVALETAQRSAEAELQSKRASFAE 1587

Query: 612  QLAELRQRLDHAEAD----RQELQDELRQEREARQKLEMMIKELKLQILKSSKTAK 663
            + A+L + L          R+E +   +Q+ EA +  E   +EL+   LK+++  +
Sbjct: 1588 KTAQLERSLQEEHVAVAQLREEAERRAQQQAEAERAREEAERELERWQLKANEALR 1643



 Score = 38.1 bits (87), Expect = 0.026
 Identities = 28/140 (20%), Positives = 69/140 (49%), Gaps = 6/140 (4%)

Query: 531  KKQQLQMEVKMLSSSKSMKELTEEQQNLQKELESLQNEHAQRMEEFYVEQKDLEKKLEQI 590
            K+ Q +M+ +++   ++  +  ++++++Q+EL+ L+      ++    + +  E+   +I
Sbjct: 1391 KELQQRMQEEVVRREEAAVDAQQQKRSIQEELQQLRQSSEAEIQAKARQAEAAERSRLRI 1450

Query: 591  MKQKCTCDSNLEKDKEAEYA--GQLAELRQRLDHAEADRQELQDEL----RQEREARQKL 644
             ++       LE  +       G+L  LR R + AEA +++ Q+E     RQ ++  Q+ 
Sbjct: 1451 EEEIRVVRLQLEATERQRGGAEGELQALRARAEEAEAQKRQAQEEAERLRRQVQDESQRK 1510

Query: 645  EMMIKELKLQILKSSKTAKE 664
                 EL  ++   ++ A+E
Sbjct: 1511 RQAEVELASRVKAEAEAARE 1530



 Score = 37.7 bits (86), Expect = 0.034
 Identities = 41/161 (25%), Positives = 79/161 (49%), Gaps = 13/161 (8%)

Query: 496  LLVKDVICEDDKGKIMEEVMRTYLKQQEKLNLILQKKQQLQMEVKMLSSSKSMKELTEEQ 555
            LL ++   E +K K+ E++ +  + + ++L    Q++QQ QME +      SM+E    Q
Sbjct: 2502 LLQRERFIEQEKAKL-EQLFQDEVAKAQQLREEQQRQQQ-QMEQERQRLVASMEEARRRQ 2559

Query: 556  -------QNLQKELESLQNEHAQRMEEFYVEQKDLEKKLEQIMKQKCTCDSNLEKDKEAE 608
                   +  Q+EL+ L+ +  Q+ E    E + L ++L+ + +Q     ++ E+   ++
Sbjct: 2560 HEAEEGVRRKQEELQQLEQQRRQQEELLAEENQRLREQLQLLEEQHRAALAHSEEVTASQ 2619

Query: 609  YAG--QLAELRQRLD--HAEADRQELQDELRQEREARQKLE 645
             A    L   R  LD   AEA+ +   D LR++  A++  E
Sbjct: 2620 VAATKTLPNGRDALDGPAAEAEPEHSFDGLRRKVSAQRLQE 2660



 Score = 35.8 bits (81), Expect = 0.13
 Identities = 54/281 (19%), Positives = 116/281 (41%), Gaps = 36/281 (12%)

Query: 396  TSAVSQSKELTKTEASKSISRQSEKAHSSGKLQKTVSYPDVSLEEQEKMDLKTSRELCSR 455
            T    Q ++L + E ++    Q E A ++ K Q+  +       E  K+  +    L S+
Sbjct: 1722 TEQGEQQRQLLEEELARL---QREAAAATQKRQELEA-------ELAKVRAEMEVLLASK 1771

Query: 456  LDASISNNSTSKRKSE--SATCNLVRDINKVGIGLVAAASSPLLVKDVICEDDKGKIMEE 513
              A   + STS++  +   A     R++ +    L A A      +  + E+D  +   E
Sbjct: 1772 ARAEEESRSTSEKSKQRLEAEAGRFRELAEEAARLRALAEEAKRQRQ-LAEEDAARQRAE 1830

Query: 514  VMRTYLKQQEKLNLILQKKQQLQMEVKMLSS-SKSMKELTEEQQNLQKELESLQNEHAQR 572
              R   ++   +    + K + ++ +K   + ++ ++ L E++   ++ LE    +H   
Sbjct: 1831 AERVLAEKLAAIGEATRLKTEAEIALKEKEAENERLRRLAEDEAFQRRRLEEQAAQH--- 1887

Query: 573  MEEFYVEQKDLEKKLEQIMKQKCTCDSNLEKDK---------EAEYAGQLAELRQRLDHA 623
                   + D+E++L Q+ K     DS LE+ K           +   ++  L+   + A
Sbjct: 1888 -------KADIEERLAQLRK---ASDSELERQKGLVEDTLRQRRQVEEEILALKASFEKA 1937

Query: 624  EADRQELQDELRQEREARQKLEMMIKELKLQILKSSKTAKE 664
             A + EL+ EL + R   +      ++ +L+  +  + A E
Sbjct: 1938 AAGKAELELELGRIRSNAEDTLRSKEQAELEAARQRQLAAE 1978



 Score = 35.0 bits (79), Expect = 0.22
 Identities = 81/419 (19%), Positives = 162/419 (38%), Gaps = 86/419 (20%)

Query: 313  QKYLGTPEE--KKLKIILEEMKE-KFSMRSGKRNQSKTDAPSGMELQSWYPVIKQEGDHV 369
            QK L   EE  ++ K  LEE++  K  +   +R + + +  S  +LQ      ++     
Sbjct: 1991 QKSLAAEEEAARQRKAALEEVERLKAKVEEARRLRERAEQESARQLQLAQEAAQKRLQAE 2050

Query: 370  SQTHSFLHPSYYLYMCDKVVAPNVSLTSAVSQSKELT-----KTEASKSISRQSEKAHSS 424
             + H+F            V      L   + Q + +      + EA++  + ++E+A   
Sbjct: 2051 EKAHAFA-----------VQQKEQELQQTLQQEQSVLDQLRGEAEAARRAAEEAEEARVQ 2099

Query: 425  GKLQKTVSYPDVSLEEQEKMDLKTSRELCSRLDASISNNSTSKRKSESATCNLVRDINKV 484
             + +   S   V  EE E++      +  +R  A  +     K   + A      +  + 
Sbjct: 2100 AEREAAQSRRQV--EEAERLKQSAEEQAQARAQAQAAAEKLRKEAEQEAARRAQAE--QA 2155

Query: 485  GIGLVAAASSPLLVKDVICED---DKGKIMEEVMRTYLKQQE---KLNLILQKKQQL--- 535
             +    AA + +       E     K ++ +E+    L+ +E   + NL+ ++ Q+L   
Sbjct: 2156 ALRQKQAADAEMEKHKKFAEQTLRQKAQVEQELTTLRLQLEETDHQKNLLDEELQRLKAE 2215

Query: 536  ---------QMEVKMLSSSKSMKELTE-------------------EQQNLQKELESLQN 567
                     Q+E ++ S    M+EL++                    Q+ LQ+E E ++ 
Sbjct: 2216 ATEAARQRSQVEEELFSVRVQMEELSKLKARIEAENRALILRDKDNTQRFLQEEAEKMKQ 2275

Query: 568  --EHAQRMEEFYVEQKDLEKKLEQIMKQKCTCDSNLEKDK------------EAEYAGQL 613
              E A R+     E   L +  E+ + Q+      + K+K            EAE   Q 
Sbjct: 2276 VAEEAARLSVAAQEAARLRQLAEEDLAQQRALAEKMLKEKMQAVQEATRLKAEAELLQQQ 2335

Query: 614  AELRQ-RLDHAEADRQELQDELRQ---------EREARQKLEMM--IKELKLQILKSSK 660
             EL Q +    + D++++  +L +         E E +++LEM    + LKL++ + S+
Sbjct: 2336 KELAQEQARRLQEDKEQMAQQLAEETQGFQRTLEAERQRQLEMSAEAERLKLRVAEMSR 2394



 Score = 32.0 bits (71), Expect = 1.9
 Identities = 34/158 (21%), Positives = 73/158 (46%), Gaps = 24/158 (15%)

Query: 512  EEVMRTY---LKQQEKLNLILQKKQQLQMEVKMLSSSKSMKE-----LTEEQQNLQKELE 563
            EEV+R +   LK+ + +   L + +  +  +K L +    ++     L +E +  Q+  E
Sbjct: 1102 EEVLRAHEEQLKEAQAVPATLPELEATKASLKKLRAQAEAQQPTFDALRDELRGAQEVGE 1161

Query: 564  SLQNEHAQR---MEEFYVEQKDLEKKLEQIMKQKCTCDSNLEK-DKEAEYAGQ------- 612
             LQ  H +R   +E +      L ++ + ++ Q       LE+  ++  Y  +       
Sbjct: 1162 RLQQRHGERDVEVERWRERVAQLLERWQAVLAQTDVRQRELEQLGRQLRYYRESADPLGA 1221

Query: 613  -LAELRQRLDHAEA----DRQELQDELRQEREARQKLE 645
             L + R+R +  +A    D Q ++++LRQE+   +++E
Sbjct: 1222 WLQDARRRQEQIQAMPLADSQAVREQLRQEQALLEEIE 1259


>gi|41322914 plectin 1 isoform 10 [Homo sapiens]
          Length = 4551

 Score = 56.6 bits (135), Expect = 7e-08
 Identities = 59/270 (21%), Positives = 123/270 (45%), Gaps = 29/270 (10%)

Query: 399  VSQSKELTKTEASKSISRQSEKAHSSGKLQKTVSYPDVSLEEQEKMDLKTSRELCSRLDA 458
            + Q KEL + +A +    Q +K   + +L +       +LE + +  L+ S E   RL  
Sbjct: 2336 LQQQKELAQEQARRL---QEDKEQMAQQLAEETQGFQRTLEAERQRQLEMSAE-AERLKL 2391

Query: 459  SISNNSTSKRKSESATCNLVRDINKVGIGL----VAAASSPLLVKDVICEDDKGKIMEEV 514
             ++  S ++ ++E       +   ++G  L    +A      LV+ +  +  +     E 
Sbjct: 2392 RVAEMSRAQARAEEDAQRFRKQAEEIGEKLHRTELATQEKVTLVQTLEIQRQQSDHDAER 2451

Query: 515  MRTYLKQQEKLNLILQKKQQLQMEVKMLSSSKSMKELTEEQQNLQKELESLQNEHAQRME 574
            +R  + + E+      +K++LQ E K+L   KS +  T +Q+ L +E ++LQ       +
Sbjct: 2452 LREAIAELER------EKEKLQQEAKLLQL-KSEEMQTVQQEQLLQETQALQQSFLSEKD 2504

Query: 575  EFYVEQKDLEK---KLEQIMKQKCTCDSNLEKDKEAEY----------AGQLAELRQRLD 621
                 ++ +E+   KLEQ+ + +      L ++++ +              + E R+R  
Sbjct: 2505 SLLQRERFIEQEKAKLEQLFQDEVAKAQQLREEQQRQQQQMEQERQRLVASMEEARRRQH 2564

Query: 622  HAEADRQELQDELRQ-EREARQKLEMMIKE 650
             AE   +  Q+EL+Q E++ RQ+ E++ +E
Sbjct: 2565 EAEEGVRRKQEELQQLEQQRRQQEELLAEE 2594



 Score = 52.4 bits (124), Expect = 1e-06
 Identities = 68/284 (23%), Positives = 126/284 (44%), Gaps = 34/284 (11%)

Query: 400  SQSKELTKTEASKSISRQSEKAHSSGKLQKTVSYPDVSLEEQEKM----DLKTSRELCSR 455
            SQ K   + E +  +  ++E A    +  + +    +  EE E+     +++ +R++   
Sbjct: 1511 SQRKRQAEVELASRVKAEAEAAREKQRALQALEELRLQAEEAERRLRQAEVERARQVQVA 1570

Query: 456  LDA---SISNNSTSKRKS-ESATCNLVRDINK--VGIGLVAAASSPLLVKDVICEDDKGK 509
            L+    S      SKR S    T  L R + +  V +  +   +     +    E  + +
Sbjct: 1571 LETAQRSAEAELQSKRASFAEKTAQLERSLQEEHVAVAQLREEAERRAQQQAEAERAREE 1630

Query: 510  IMEEVMRTYLKQQEKLNLILQKKQQLQMEVKMLSSSKSMKELTEEQQNLQKELESLQNEH 569
               E+ R  LK  E L L LQ ++  Q         KS+ +   E+Q  + E E+ +   
Sbjct: 1631 AERELERWQLKANEALRLRLQAEEVAQQ--------KSLAQAEAEKQKEEAEREARRRGK 1682

Query: 570  AQRMEEFYVEQKDLEKKLEQIMKQKCTCDSNLEKDKEAEYAGQLAELRQRLDHAEADRQE 629
            A   EE  V Q++L +  +++ KQ+   +   ++   AE   +L  LR   +  E  RQ 
Sbjct: 1683 A---EEQAVRQRELAE--QELEKQRQLAEGTAQQRLAAEQ--ELIRLRAETEQGEQQRQL 1735

Query: 630  LQDEL-RQEREA------RQKLEMMIKELK--LQILKSSKTAKE 664
            L++EL R +REA      RQ+LE  + +++  +++L +SK   E
Sbjct: 1736 LEEELARLQREAAAATQKRQELEAELAKVRAEMEVLLASKARAE 1779



 Score = 44.3 bits (103), Expect = 4e-04
 Identities = 65/296 (21%), Positives = 123/296 (41%), Gaps = 43/296 (14%)

Query: 401  QSKELTKTEASKSISRQSEKAHSSGK---------LQKTVSYPDVSLEE------QEKMD 445
            + + L + EA+    RQ  +AH+  K         LQ+ +    V  EE      Q+K  
Sbjct: 1362 ERERLAEVEAALEKQRQLAEAHAQAKAQAEREAKELQQRMQEEVVRREEAAVDAQQQKRS 1421

Query: 446  LKTS-RELCSRLDASISNNSTSKRKSESATCNLVRDINKVGIGLVAAAS---------SP 495
            ++   ++L    +A I   +     +E +   +  +I  V + L A              
Sbjct: 1422 IQEELQQLRQSSEAEIQAKARQAEAAERSRLRIEEEIRVVRLQLEATERQRGGAEGELQA 1481

Query: 496  LLVKDVICEDDKGKIMEEVMRTYLKQQEKLNLILQKKQQLQMEVKMLSSSKSMKELTEEQ 555
            L  +    E  K +  EE  R   + Q+      + +++ Q EV++ S  K+  E   E+
Sbjct: 1482 LRARAEEAEAQKRQAQEEAERLRRQVQD------ESQRKRQAEVELASRVKAEAEAAREK 1535

Query: 556  QNLQKELES--LQNEHAQRMEEFYVEQKDLEKKLE-QIMKQKCTCDSNLE-KDKEAEYAG 611
            Q   + LE   LQ E A+R     + Q ++E+  + Q+  +     +  E + K A +A 
Sbjct: 1536 QRALQALEELRLQAEEAERR----LRQAEVERARQVQVALETAQRSAEAELQSKRASFAE 1591

Query: 612  QLAELRQRLDHAEAD----RQELQDELRQEREARQKLEMMIKELKLQILKSSKTAK 663
            + A+L + L          R+E +   +Q+ EA +  E   +EL+   LK+++  +
Sbjct: 1592 KTAQLERSLQEEHVAVAQLREEAERRAQQQAEAERAREEAERELERWQLKANEALR 1647



 Score = 38.1 bits (87), Expect = 0.026
 Identities = 28/140 (20%), Positives = 69/140 (49%), Gaps = 6/140 (4%)

Query: 531  KKQQLQMEVKMLSSSKSMKELTEEQQNLQKELESLQNEHAQRMEEFYVEQKDLEKKLEQI 590
            K+ Q +M+ +++   ++  +  ++++++Q+EL+ L+      ++    + +  E+   +I
Sbjct: 1395 KELQQRMQEEVVRREEAAVDAQQQKRSIQEELQQLRQSSEAEIQAKARQAEAAERSRLRI 1454

Query: 591  MKQKCTCDSNLEKDKEAEYA--GQLAELRQRLDHAEADRQELQDEL----RQEREARQKL 644
             ++       LE  +       G+L  LR R + AEA +++ Q+E     RQ ++  Q+ 
Sbjct: 1455 EEEIRVVRLQLEATERQRGGAEGELQALRARAEEAEAQKRQAQEEAERLRRQVQDESQRK 1514

Query: 645  EMMIKELKLQILKSSKTAKE 664
                 EL  ++   ++ A+E
Sbjct: 1515 RQAEVELASRVKAEAEAARE 1534



 Score = 37.7 bits (86), Expect = 0.034
 Identities = 41/161 (25%), Positives = 79/161 (49%), Gaps = 13/161 (8%)

Query: 496  LLVKDVICEDDKGKIMEEVMRTYLKQQEKLNLILQKKQQLQMEVKMLSSSKSMKELTEEQ 555
            LL ++   E +K K+ E++ +  + + ++L    Q++QQ QME +      SM+E    Q
Sbjct: 2506 LLQRERFIEQEKAKL-EQLFQDEVAKAQQLREEQQRQQQ-QMEQERQRLVASMEEARRRQ 2563

Query: 556  -------QNLQKELESLQNEHAQRMEEFYVEQKDLEKKLEQIMKQKCTCDSNLEKDKEAE 608
                   +  Q+EL+ L+ +  Q+ E    E + L ++L+ + +Q     ++ E+   ++
Sbjct: 2564 HEAEEGVRRKQEELQQLEQQRRQQEELLAEENQRLREQLQLLEEQHRAALAHSEEVTASQ 2623

Query: 609  YAG--QLAELRQRLD--HAEADRQELQDELRQEREARQKLE 645
             A    L   R  LD   AEA+ +   D LR++  A++  E
Sbjct: 2624 VAATKTLPNGRDALDGPAAEAEPEHSFDGLRRKVSAQRLQE 2664



 Score = 35.8 bits (81), Expect = 0.13
 Identities = 54/281 (19%), Positives = 116/281 (41%), Gaps = 36/281 (12%)

Query: 396  TSAVSQSKELTKTEASKSISRQSEKAHSSGKLQKTVSYPDVSLEEQEKMDLKTSRELCSR 455
            T    Q ++L + E ++    Q E A ++ K Q+  +       E  K+  +    L S+
Sbjct: 1726 TEQGEQQRQLLEEELARL---QREAAAATQKRQELEA-------ELAKVRAEMEVLLASK 1775

Query: 456  LDASISNNSTSKRKSE--SATCNLVRDINKVGIGLVAAASSPLLVKDVICEDDKGKIMEE 513
              A   + STS++  +   A     R++ +    L A A      +  + E+D  +   E
Sbjct: 1776 ARAEEESRSTSEKSKQRLEAEAGRFRELAEEAARLRALAEEAKRQRQ-LAEEDAARQRAE 1834

Query: 514  VMRTYLKQQEKLNLILQKKQQLQMEVKMLSS-SKSMKELTEEQQNLQKELESLQNEHAQR 572
              R   ++   +    + K + ++ +K   + ++ ++ L E++   ++ LE    +H   
Sbjct: 1835 AERVLAEKLAAIGEATRLKTEAEIALKEKEAENERLRRLAEDEAFQRRRLEEQAAQH--- 1891

Query: 573  MEEFYVEQKDLEKKLEQIMKQKCTCDSNLEKDK---------EAEYAGQLAELRQRLDHA 623
                   + D+E++L Q+ K     DS LE+ K           +   ++  L+   + A
Sbjct: 1892 -------KADIEERLAQLRK---ASDSELERQKGLVEDTLRQRRQVEEEILALKASFEKA 1941

Query: 624  EADRQELQDELRQEREARQKLEMMIKELKLQILKSSKTAKE 664
             A + EL+ EL + R   +      ++ +L+  +  + A E
Sbjct: 1942 AAGKAELELELGRIRSNAEDTLRSKEQAELEAARQRQLAAE 1982



 Score = 35.0 bits (79), Expect = 0.22
 Identities = 81/419 (19%), Positives = 162/419 (38%), Gaps = 86/419 (20%)

Query: 313  QKYLGTPEE--KKLKIILEEMKE-KFSMRSGKRNQSKTDAPSGMELQSWYPVIKQEGDHV 369
            QK L   EE  ++ K  LEE++  K  +   +R + + +  S  +LQ      ++     
Sbjct: 1995 QKSLAAEEEAARQRKAALEEVERLKAKVEEARRLRERAEQESARQLQLAQEAAQKRLQAE 2054

Query: 370  SQTHSFLHPSYYLYMCDKVVAPNVSLTSAVSQSKELT-----KTEASKSISRQSEKAHSS 424
             + H+F            V      L   + Q + +      + EA++  + ++E+A   
Sbjct: 2055 EKAHAFA-----------VQQKEQELQQTLQQEQSVLDQLRGEAEAARRAAEEAEEARVQ 2103

Query: 425  GKLQKTVSYPDVSLEEQEKMDLKTSRELCSRLDASISNNSTSKRKSESATCNLVRDINKV 484
             + +   S   V  EE E++      +  +R  A  +     K   + A      +  + 
Sbjct: 2104 AEREAAQSRRQV--EEAERLKQSAEEQAQARAQAQAAAEKLRKEAEQEAARRAQAE--QA 2159

Query: 485  GIGLVAAASSPLLVKDVICED---DKGKIMEEVMRTYLKQQE---KLNLILQKKQQL--- 535
             +    AA + +       E     K ++ +E+    L+ +E   + NL+ ++ Q+L   
Sbjct: 2160 ALRQKQAADAEMEKHKKFAEQTLRQKAQVEQELTTLRLQLEETDHQKNLLDEELQRLKAE 2219

Query: 536  ---------QMEVKMLSSSKSMKELTE-------------------EQQNLQKELESLQN 567
                     Q+E ++ S    M+EL++                    Q+ LQ+E E ++ 
Sbjct: 2220 ATEAARQRSQVEEELFSVRVQMEELSKLKARIEAENRALILRDKDNTQRFLQEEAEKMKQ 2279

Query: 568  --EHAQRMEEFYVEQKDLEKKLEQIMKQKCTCDSNLEKDK------------EAEYAGQL 613
              E A R+     E   L +  E+ + Q+      + K+K            EAE   Q 
Sbjct: 2280 VAEEAARLSVAAQEAARLRQLAEEDLAQQRALAEKMLKEKMQAVQEATRLKAEAELLQQQ 2339

Query: 614  AELRQ-RLDHAEADRQELQDELRQ---------EREARQKLEMM--IKELKLQILKSSK 660
             EL Q +    + D++++  +L +         E E +++LEM    + LKL++ + S+
Sbjct: 2340 KELAQEQARRLQEDKEQMAQQLAEETQGFQRTLEAERQRQLEMSAEAERLKLRVAEMSR 2398



 Score = 32.0 bits (71), Expect = 1.9
 Identities = 34/158 (21%), Positives = 73/158 (46%), Gaps = 24/158 (15%)

Query: 512  EEVMRTY---LKQQEKLNLILQKKQQLQMEVKMLSSSKSMKE-----LTEEQQNLQKELE 563
            EEV+R +   LK+ + +   L + +  +  +K L +    ++     L +E +  Q+  E
Sbjct: 1106 EEVLRAHEEQLKEAQAVPATLPELEATKASLKKLRAQAEAQQPTFDALRDELRGAQEVGE 1165

Query: 564  SLQNEHAQR---MEEFYVEQKDLEKKLEQIMKQKCTCDSNLEK-DKEAEYAGQ------- 612
             LQ  H +R   +E +      L ++ + ++ Q       LE+  ++  Y  +       
Sbjct: 1166 RLQQRHGERDVEVERWRERVAQLLERWQAVLAQTDVRQRELEQLGRQLRYYRESADPLGA 1225

Query: 613  -LAELRQRLDHAEA----DRQELQDELRQEREARQKLE 645
             L + R+R +  +A    D Q ++++LRQE+   +++E
Sbjct: 1226 WLQDARRRQEQIQAMPLADSQAVREQLRQEQALLEEIE 1263


>gi|41322919 plectin 1 isoform 8 [Homo sapiens]
          Length = 4547

 Score = 56.6 bits (135), Expect = 7e-08
 Identities = 59/270 (21%), Positives = 123/270 (45%), Gaps = 29/270 (10%)

Query: 399  VSQSKELTKTEASKSISRQSEKAHSSGKLQKTVSYPDVSLEEQEKMDLKTSRELCSRLDA 458
            + Q KEL + +A +    Q +K   + +L +       +LE + +  L+ S E   RL  
Sbjct: 2332 LQQQKELAQEQARRL---QEDKEQMAQQLAEETQGFQRTLEAERQRQLEMSAE-AERLKL 2387

Query: 459  SISNNSTSKRKSESATCNLVRDINKVGIGL----VAAASSPLLVKDVICEDDKGKIMEEV 514
             ++  S ++ ++E       +   ++G  L    +A      LV+ +  +  +     E 
Sbjct: 2388 RVAEMSRAQARAEEDAQRFRKQAEEIGEKLHRTELATQEKVTLVQTLEIQRQQSDHDAER 2447

Query: 515  MRTYLKQQEKLNLILQKKQQLQMEVKMLSSSKSMKELTEEQQNLQKELESLQNEHAQRME 574
            +R  + + E+      +K++LQ E K+L   KS +  T +Q+ L +E ++LQ       +
Sbjct: 2448 LREAIAELER------EKEKLQQEAKLLQL-KSEEMQTVQQEQLLQETQALQQSFLSEKD 2500

Query: 575  EFYVEQKDLEK---KLEQIMKQKCTCDSNLEKDKEAEY----------AGQLAELRQRLD 621
                 ++ +E+   KLEQ+ + +      L ++++ +              + E R+R  
Sbjct: 2501 SLLQRERFIEQEKAKLEQLFQDEVAKAQQLREEQQRQQQQMEQERQRLVASMEEARRRQH 2560

Query: 622  HAEADRQELQDELRQ-EREARQKLEMMIKE 650
             AE   +  Q+EL+Q E++ RQ+ E++ +E
Sbjct: 2561 EAEEGVRRKQEELQQLEQQRRQQEELLAEE 2590



 Score = 52.4 bits (124), Expect = 1e-06
 Identities = 68/284 (23%), Positives = 126/284 (44%), Gaps = 34/284 (11%)

Query: 400  SQSKELTKTEASKSISRQSEKAHSSGKLQKTVSYPDVSLEEQEKM----DLKTSRELCSR 455
            SQ K   + E +  +  ++E A    +  + +    +  EE E+     +++ +R++   
Sbjct: 1507 SQRKRQAEVELASRVKAEAEAAREKQRALQALEELRLQAEEAERRLRQAEVERARQVQVA 1566

Query: 456  LDA---SISNNSTSKRKS-ESATCNLVRDINK--VGIGLVAAASSPLLVKDVICEDDKGK 509
            L+    S      SKR S    T  L R + +  V +  +   +     +    E  + +
Sbjct: 1567 LETAQRSAEAELQSKRASFAEKTAQLERSLQEEHVAVAQLREEAERRAQQQAEAERAREE 1626

Query: 510  IMEEVMRTYLKQQEKLNLILQKKQQLQMEVKMLSSSKSMKELTEEQQNLQKELESLQNEH 569
               E+ R  LK  E L L LQ ++  Q         KS+ +   E+Q  + E E+ +   
Sbjct: 1627 AERELERWQLKANEALRLRLQAEEVAQQ--------KSLAQAEAEKQKEEAEREARRRGK 1678

Query: 570  AQRMEEFYVEQKDLEKKLEQIMKQKCTCDSNLEKDKEAEYAGQLAELRQRLDHAEADRQE 629
            A   EE  V Q++L +  +++ KQ+   +   ++   AE   +L  LR   +  E  RQ 
Sbjct: 1679 A---EEQAVRQRELAE--QELEKQRQLAEGTAQQRLAAEQ--ELIRLRAETEQGEQQRQL 1731

Query: 630  LQDEL-RQEREA------RQKLEMMIKELK--LQILKSSKTAKE 664
            L++EL R +REA      RQ+LE  + +++  +++L +SK   E
Sbjct: 1732 LEEELARLQREAAAATQKRQELEAELAKVRAEMEVLLASKARAE 1775



 Score = 44.3 bits (103), Expect = 4e-04
 Identities = 65/296 (21%), Positives = 123/296 (41%), Gaps = 43/296 (14%)

Query: 401  QSKELTKTEASKSISRQSEKAHSSGK---------LQKTVSYPDVSLEE------QEKMD 445
            + + L + EA+    RQ  +AH+  K         LQ+ +    V  EE      Q+K  
Sbjct: 1358 ERERLAEVEAALEKQRQLAEAHAQAKAQAEREAKELQQRMQEEVVRREEAAVDAQQQKRS 1417

Query: 446  LKTS-RELCSRLDASISNNSTSKRKSESATCNLVRDINKVGIGLVAAAS---------SP 495
            ++   ++L    +A I   +     +E +   +  +I  V + L A              
Sbjct: 1418 IQEELQQLRQSSEAEIQAKARQAEAAERSRLRIEEEIRVVRLQLEATERQRGGAEGELQA 1477

Query: 496  LLVKDVICEDDKGKIMEEVMRTYLKQQEKLNLILQKKQQLQMEVKMLSSSKSMKELTEEQ 555
            L  +    E  K +  EE  R   + Q+      + +++ Q EV++ S  K+  E   E+
Sbjct: 1478 LRARAEEAEAQKRQAQEEAERLRRQVQD------ESQRKRQAEVELASRVKAEAEAAREK 1531

Query: 556  QNLQKELES--LQNEHAQRMEEFYVEQKDLEKKLE-QIMKQKCTCDSNLE-KDKEAEYAG 611
            Q   + LE   LQ E A+R     + Q ++E+  + Q+  +     +  E + K A +A 
Sbjct: 1532 QRALQALEELRLQAEEAERR----LRQAEVERARQVQVALETAQRSAEAELQSKRASFAE 1587

Query: 612  QLAELRQRLDHAEAD----RQELQDELRQEREARQKLEMMIKELKLQILKSSKTAK 663
            + A+L + L          R+E +   +Q+ EA +  E   +EL+   LK+++  +
Sbjct: 1588 KTAQLERSLQEEHVAVAQLREEAERRAQQQAEAERAREEAERELERWQLKANEALR 1643



 Score = 38.1 bits (87), Expect = 0.026
 Identities = 28/140 (20%), Positives = 69/140 (49%), Gaps = 6/140 (4%)

Query: 531  KKQQLQMEVKMLSSSKSMKELTEEQQNLQKELESLQNEHAQRMEEFYVEQKDLEKKLEQI 590
            K+ Q +M+ +++   ++  +  ++++++Q+EL+ L+      ++    + +  E+   +I
Sbjct: 1391 KELQQRMQEEVVRREEAAVDAQQQKRSIQEELQQLRQSSEAEIQAKARQAEAAERSRLRI 1450

Query: 591  MKQKCTCDSNLEKDKEAEYA--GQLAELRQRLDHAEADRQELQDEL----RQEREARQKL 644
             ++       LE  +       G+L  LR R + AEA +++ Q+E     RQ ++  Q+ 
Sbjct: 1451 EEEIRVVRLQLEATERQRGGAEGELQALRARAEEAEAQKRQAQEEAERLRRQVQDESQRK 1510

Query: 645  EMMIKELKLQILKSSKTAKE 664
                 EL  ++   ++ A+E
Sbjct: 1511 RQAEVELASRVKAEAEAARE 1530



 Score = 37.7 bits (86), Expect = 0.034
 Identities = 41/161 (25%), Positives = 79/161 (49%), Gaps = 13/161 (8%)

Query: 496  LLVKDVICEDDKGKIMEEVMRTYLKQQEKLNLILQKKQQLQMEVKMLSSSKSMKELTEEQ 555
            LL ++   E +K K+ E++ +  + + ++L    Q++QQ QME +      SM+E    Q
Sbjct: 2502 LLQRERFIEQEKAKL-EQLFQDEVAKAQQLREEQQRQQQ-QMEQERQRLVASMEEARRRQ 2559

Query: 556  -------QNLQKELESLQNEHAQRMEEFYVEQKDLEKKLEQIMKQKCTCDSNLEKDKEAE 608
                   +  Q+EL+ L+ +  Q+ E    E + L ++L+ + +Q     ++ E+   ++
Sbjct: 2560 HEAEEGVRRKQEELQQLEQQRRQQEELLAEENQRLREQLQLLEEQHRAALAHSEEVTASQ 2619

Query: 609  YAG--QLAELRQRLD--HAEADRQELQDELRQEREARQKLE 645
             A    L   R  LD   AEA+ +   D LR++  A++  E
Sbjct: 2620 VAATKTLPNGRDALDGPAAEAEPEHSFDGLRRKVSAQRLQE 2660



 Score = 35.8 bits (81), Expect = 0.13
 Identities = 54/281 (19%), Positives = 116/281 (41%), Gaps = 36/281 (12%)

Query: 396  TSAVSQSKELTKTEASKSISRQSEKAHSSGKLQKTVSYPDVSLEEQEKMDLKTSRELCSR 455
            T    Q ++L + E ++    Q E A ++ K Q+  +       E  K+  +    L S+
Sbjct: 1722 TEQGEQQRQLLEEELARL---QREAAAATQKRQELEA-------ELAKVRAEMEVLLASK 1771

Query: 456  LDASISNNSTSKRKSE--SATCNLVRDINKVGIGLVAAASSPLLVKDVICEDDKGKIMEE 513
              A   + STS++  +   A     R++ +    L A A      +  + E+D  +   E
Sbjct: 1772 ARAEEESRSTSEKSKQRLEAEAGRFRELAEEAARLRALAEEAKRQRQ-LAEEDAARQRAE 1830

Query: 514  VMRTYLKQQEKLNLILQKKQQLQMEVKMLSS-SKSMKELTEEQQNLQKELESLQNEHAQR 572
              R   ++   +    + K + ++ +K   + ++ ++ L E++   ++ LE    +H   
Sbjct: 1831 AERVLAEKLAAIGEATRLKTEAEIALKEKEAENERLRRLAEDEAFQRRRLEEQAAQH--- 1887

Query: 573  MEEFYVEQKDLEKKLEQIMKQKCTCDSNLEKDK---------EAEYAGQLAELRQRLDHA 623
                   + D+E++L Q+ K     DS LE+ K           +   ++  L+   + A
Sbjct: 1888 -------KADIEERLAQLRK---ASDSELERQKGLVEDTLRQRRQVEEEILALKASFEKA 1937

Query: 624  EADRQELQDELRQEREARQKLEMMIKELKLQILKSSKTAKE 664
             A + EL+ EL + R   +      ++ +L+  +  + A E
Sbjct: 1938 AAGKAELELELGRIRSNAEDTLRSKEQAELEAARQRQLAAE 1978



 Score = 35.0 bits (79), Expect = 0.22
 Identities = 81/419 (19%), Positives = 162/419 (38%), Gaps = 86/419 (20%)

Query: 313  QKYLGTPEE--KKLKIILEEMKE-KFSMRSGKRNQSKTDAPSGMELQSWYPVIKQEGDHV 369
            QK L   EE  ++ K  LEE++  K  +   +R + + +  S  +LQ      ++     
Sbjct: 1991 QKSLAAEEEAARQRKAALEEVERLKAKVEEARRLRERAEQESARQLQLAQEAAQKRLQAE 2050

Query: 370  SQTHSFLHPSYYLYMCDKVVAPNVSLTSAVSQSKELT-----KTEASKSISRQSEKAHSS 424
             + H+F            V      L   + Q + +      + EA++  + ++E+A   
Sbjct: 2051 EKAHAFA-----------VQQKEQELQQTLQQEQSVLDQLRGEAEAARRAAEEAEEARVQ 2099

Query: 425  GKLQKTVSYPDVSLEEQEKMDLKTSRELCSRLDASISNNSTSKRKSESATCNLVRDINKV 484
             + +   S   V  EE E++      +  +R  A  +     K   + A      +  + 
Sbjct: 2100 AEREAAQSRRQV--EEAERLKQSAEEQAQARAQAQAAAEKLRKEAEQEAARRAQAE--QA 2155

Query: 485  GIGLVAAASSPLLVKDVICED---DKGKIMEEVMRTYLKQQE---KLNLILQKKQQL--- 535
             +    AA + +       E     K ++ +E+    L+ +E   + NL+ ++ Q+L   
Sbjct: 2156 ALRQKQAADAEMEKHKKFAEQTLRQKAQVEQELTTLRLQLEETDHQKNLLDEELQRLKAE 2215

Query: 536  ---------QMEVKMLSSSKSMKELTE-------------------EQQNLQKELESLQN 567
                     Q+E ++ S    M+EL++                    Q+ LQ+E E ++ 
Sbjct: 2216 ATEAARQRSQVEEELFSVRVQMEELSKLKARIEAENRALILRDKDNTQRFLQEEAEKMKQ 2275

Query: 568  --EHAQRMEEFYVEQKDLEKKLEQIMKQKCTCDSNLEKDK------------EAEYAGQL 613
              E A R+     E   L +  E+ + Q+      + K+K            EAE   Q 
Sbjct: 2276 VAEEAARLSVAAQEAARLRQLAEEDLAQQRALAEKMLKEKMQAVQEATRLKAEAELLQQQ 2335

Query: 614  AELRQ-RLDHAEADRQELQDELRQ---------EREARQKLEMM--IKELKLQILKSSK 660
             EL Q +    + D++++  +L +         E E +++LEM    + LKL++ + S+
Sbjct: 2336 KELAQEQARRLQEDKEQMAQQLAEETQGFQRTLEAERQRQLEMSAEAERLKLRVAEMSR 2394



 Score = 32.0 bits (71), Expect = 1.9
 Identities = 34/158 (21%), Positives = 73/158 (46%), Gaps = 24/158 (15%)

Query: 512  EEVMRTY---LKQQEKLNLILQKKQQLQMEVKMLSSSKSMKE-----LTEEQQNLQKELE 563
            EEV+R +   LK+ + +   L + +  +  +K L +    ++     L +E +  Q+  E
Sbjct: 1102 EEVLRAHEEQLKEAQAVPATLPELEATKASLKKLRAQAEAQQPTFDALRDELRGAQEVGE 1161

Query: 564  SLQNEHAQR---MEEFYVEQKDLEKKLEQIMKQKCTCDSNLEK-DKEAEYAGQ------- 612
             LQ  H +R   +E +      L ++ + ++ Q       LE+  ++  Y  +       
Sbjct: 1162 RLQQRHGERDVEVERWRERVAQLLERWQAVLAQTDVRQRELEQLGRQLRYYRESADPLGA 1221

Query: 613  -LAELRQRLDHAEA----DRQELQDELRQEREARQKLE 645
             L + R+R +  +A    D Q ++++LRQE+   +++E
Sbjct: 1222 WLQDARRRQEQIQAMPLADSQAVREQLRQEQALLEEIE 1259


>gi|41322910 plectin 1 isoform 7 [Homo sapiens]
          Length = 4515

 Score = 56.6 bits (135), Expect = 7e-08
 Identities = 59/270 (21%), Positives = 123/270 (45%), Gaps = 29/270 (10%)

Query: 399  VSQSKELTKTEASKSISRQSEKAHSSGKLQKTVSYPDVSLEEQEKMDLKTSRELCSRLDA 458
            + Q KEL + +A +    Q +K   + +L +       +LE + +  L+ S E   RL  
Sbjct: 2300 LQQQKELAQEQARRL---QEDKEQMAQQLAEETQGFQRTLEAERQRQLEMSAE-AERLKL 2355

Query: 459  SISNNSTSKRKSESATCNLVRDINKVGIGL----VAAASSPLLVKDVICEDDKGKIMEEV 514
             ++  S ++ ++E       +   ++G  L    +A      LV+ +  +  +     E 
Sbjct: 2356 RVAEMSRAQARAEEDAQRFRKQAEEIGEKLHRTELATQEKVTLVQTLEIQRQQSDHDAER 2415

Query: 515  MRTYLKQQEKLNLILQKKQQLQMEVKMLSSSKSMKELTEEQQNLQKELESLQNEHAQRME 574
            +R  + + E+      +K++LQ E K+L   KS +  T +Q+ L +E ++LQ       +
Sbjct: 2416 LREAIAELER------EKEKLQQEAKLLQL-KSEEMQTVQQEQLLQETQALQQSFLSEKD 2468

Query: 575  EFYVEQKDLEK---KLEQIMKQKCTCDSNLEKDKEAEY----------AGQLAELRQRLD 621
                 ++ +E+   KLEQ+ + +      L ++++ +              + E R+R  
Sbjct: 2469 SLLQRERFIEQEKAKLEQLFQDEVAKAQQLREEQQRQQQQMEQERQRLVASMEEARRRQH 2528

Query: 622  HAEADRQELQDELRQ-EREARQKLEMMIKE 650
             AE   +  Q+EL+Q E++ RQ+ E++ +E
Sbjct: 2529 EAEEGVRRKQEELQQLEQQRRQQEELLAEE 2558



 Score = 52.4 bits (124), Expect = 1e-06
 Identities = 68/284 (23%), Positives = 126/284 (44%), Gaps = 34/284 (11%)

Query: 400  SQSKELTKTEASKSISRQSEKAHSSGKLQKTVSYPDVSLEEQEKM----DLKTSRELCSR 455
            SQ K   + E +  +  ++E A    +  + +    +  EE E+     +++ +R++   
Sbjct: 1475 SQRKRQAEVELASRVKAEAEAAREKQRALQALEELRLQAEEAERRLRQAEVERARQVQVA 1534

Query: 456  LDA---SISNNSTSKRKS-ESATCNLVRDINK--VGIGLVAAASSPLLVKDVICEDDKGK 509
            L+    S      SKR S    T  L R + +  V +  +   +     +    E  + +
Sbjct: 1535 LETAQRSAEAELQSKRASFAEKTAQLERSLQEEHVAVAQLREEAERRAQQQAEAERAREE 1594

Query: 510  IMEEVMRTYLKQQEKLNLILQKKQQLQMEVKMLSSSKSMKELTEEQQNLQKELESLQNEH 569
               E+ R  LK  E L L LQ ++  Q         KS+ +   E+Q  + E E+ +   
Sbjct: 1595 AERELERWQLKANEALRLRLQAEEVAQQ--------KSLAQAEAEKQKEEAEREARRRGK 1646

Query: 570  AQRMEEFYVEQKDLEKKLEQIMKQKCTCDSNLEKDKEAEYAGQLAELRQRLDHAEADRQE 629
            A   EE  V Q++L +  +++ KQ+   +   ++   AE   +L  LR   +  E  RQ 
Sbjct: 1647 A---EEQAVRQRELAE--QELEKQRQLAEGTAQQRLAAEQ--ELIRLRAETEQGEQQRQL 1699

Query: 630  LQDEL-RQEREA------RQKLEMMIKELK--LQILKSSKTAKE 664
            L++EL R +REA      RQ+LE  + +++  +++L +SK   E
Sbjct: 1700 LEEELARLQREAAAATQKRQELEAELAKVRAEMEVLLASKARAE 1743



 Score = 44.3 bits (103), Expect = 4e-04
 Identities = 65/296 (21%), Positives = 123/296 (41%), Gaps = 43/296 (14%)

Query: 401  QSKELTKTEASKSISRQSEKAHSSGK---------LQKTVSYPDVSLEE------QEKMD 445
            + + L + EA+    RQ  +AH+  K         LQ+ +    V  EE      Q+K  
Sbjct: 1326 ERERLAEVEAALEKQRQLAEAHAQAKAQAEREAKELQQRMQEEVVRREEAAVDAQQQKRS 1385

Query: 446  LKTS-RELCSRLDASISNNSTSKRKSESATCNLVRDINKVGIGLVAAAS---------SP 495
            ++   ++L    +A I   +     +E +   +  +I  V + L A              
Sbjct: 1386 IQEELQQLRQSSEAEIQAKARQAEAAERSRLRIEEEIRVVRLQLEATERQRGGAEGELQA 1445

Query: 496  LLVKDVICEDDKGKIMEEVMRTYLKQQEKLNLILQKKQQLQMEVKMLSSSKSMKELTEEQ 555
            L  +    E  K +  EE  R   + Q+      + +++ Q EV++ S  K+  E   E+
Sbjct: 1446 LRARAEEAEAQKRQAQEEAERLRRQVQD------ESQRKRQAEVELASRVKAEAEAAREK 1499

Query: 556  QNLQKELES--LQNEHAQRMEEFYVEQKDLEKKLE-QIMKQKCTCDSNLE-KDKEAEYAG 611
            Q   + LE   LQ E A+R     + Q ++E+  + Q+  +     +  E + K A +A 
Sbjct: 1500 QRALQALEELRLQAEEAERR----LRQAEVERARQVQVALETAQRSAEAELQSKRASFAE 1555

Query: 612  QLAELRQRLDHAEAD----RQELQDELRQEREARQKLEMMIKELKLQILKSSKTAK 663
            + A+L + L          R+E +   +Q+ EA +  E   +EL+   LK+++  +
Sbjct: 1556 KTAQLERSLQEEHVAVAQLREEAERRAQQQAEAERAREEAERELERWQLKANEALR 1611



 Score = 38.1 bits (87), Expect = 0.026
 Identities = 28/140 (20%), Positives = 69/140 (49%), Gaps = 6/140 (4%)

Query: 531  KKQQLQMEVKMLSSSKSMKELTEEQQNLQKELESLQNEHAQRMEEFYVEQKDLEKKLEQI 590
            K+ Q +M+ +++   ++  +  ++++++Q+EL+ L+      ++    + +  E+   +I
Sbjct: 1359 KELQQRMQEEVVRREEAAVDAQQQKRSIQEELQQLRQSSEAEIQAKARQAEAAERSRLRI 1418

Query: 591  MKQKCTCDSNLEKDKEAEYA--GQLAELRQRLDHAEADRQELQDEL----RQEREARQKL 644
             ++       LE  +       G+L  LR R + AEA +++ Q+E     RQ ++  Q+ 
Sbjct: 1419 EEEIRVVRLQLEATERQRGGAEGELQALRARAEEAEAQKRQAQEEAERLRRQVQDESQRK 1478

Query: 645  EMMIKELKLQILKSSKTAKE 664
                 EL  ++   ++ A+E
Sbjct: 1479 RQAEVELASRVKAEAEAARE 1498



 Score = 37.7 bits (86), Expect = 0.034
 Identities = 41/161 (25%), Positives = 79/161 (49%), Gaps = 13/161 (8%)

Query: 496  LLVKDVICEDDKGKIMEEVMRTYLKQQEKLNLILQKKQQLQMEVKMLSSSKSMKELTEEQ 555
            LL ++   E +K K+ E++ +  + + ++L    Q++QQ QME +      SM+E    Q
Sbjct: 2470 LLQRERFIEQEKAKL-EQLFQDEVAKAQQLREEQQRQQQ-QMEQERQRLVASMEEARRRQ 2527

Query: 556  -------QNLQKELESLQNEHAQRMEEFYVEQKDLEKKLEQIMKQKCTCDSNLEKDKEAE 608
                   +  Q+EL+ L+ +  Q+ E    E + L ++L+ + +Q     ++ E+   ++
Sbjct: 2528 HEAEEGVRRKQEELQQLEQQRRQQEELLAEENQRLREQLQLLEEQHRAALAHSEEVTASQ 2587

Query: 609  YAG--QLAELRQRLD--HAEADRQELQDELRQEREARQKLE 645
             A    L   R  LD   AEA+ +   D LR++  A++  E
Sbjct: 2588 VAATKTLPNGRDALDGPAAEAEPEHSFDGLRRKVSAQRLQE 2628



 Score = 35.8 bits (81), Expect = 0.13
 Identities = 54/281 (19%), Positives = 116/281 (41%), Gaps = 36/281 (12%)

Query: 396  TSAVSQSKELTKTEASKSISRQSEKAHSSGKLQKTVSYPDVSLEEQEKMDLKTSRELCSR 455
            T    Q ++L + E ++    Q E A ++ K Q+  +       E  K+  +    L S+
Sbjct: 1690 TEQGEQQRQLLEEELARL---QREAAAATQKRQELEA-------ELAKVRAEMEVLLASK 1739

Query: 456  LDASISNNSTSKRKSE--SATCNLVRDINKVGIGLVAAASSPLLVKDVICEDDKGKIMEE 513
              A   + STS++  +   A     R++ +    L A A      +  + E+D  +   E
Sbjct: 1740 ARAEEESRSTSEKSKQRLEAEAGRFRELAEEAARLRALAEEAKRQRQ-LAEEDAARQRAE 1798

Query: 514  VMRTYLKQQEKLNLILQKKQQLQMEVKMLSS-SKSMKELTEEQQNLQKELESLQNEHAQR 572
              R   ++   +    + K + ++ +K   + ++ ++ L E++   ++ LE    +H   
Sbjct: 1799 AERVLAEKLAAIGEATRLKTEAEIALKEKEAENERLRRLAEDEAFQRRRLEEQAAQH--- 1855

Query: 573  MEEFYVEQKDLEKKLEQIMKQKCTCDSNLEKDK---------EAEYAGQLAELRQRLDHA 623
                   + D+E++L Q+ K     DS LE+ K           +   ++  L+   + A
Sbjct: 1856 -------KADIEERLAQLRK---ASDSELERQKGLVEDTLRQRRQVEEEILALKASFEKA 1905

Query: 624  EADRQELQDELRQEREARQKLEMMIKELKLQILKSSKTAKE 664
             A + EL+ EL + R   +      ++ +L+  +  + A E
Sbjct: 1906 AAGKAELELELGRIRSNAEDTLRSKEQAELEAARQRQLAAE 1946



 Score = 35.0 bits (79), Expect = 0.22
 Identities = 81/419 (19%), Positives = 162/419 (38%), Gaps = 86/419 (20%)

Query: 313  QKYLGTPEE--KKLKIILEEMKE-KFSMRSGKRNQSKTDAPSGMELQSWYPVIKQEGDHV 369
            QK L   EE  ++ K  LEE++  K  +   +R + + +  S  +LQ      ++     
Sbjct: 1959 QKSLAAEEEAARQRKAALEEVERLKAKVEEARRLRERAEQESARQLQLAQEAAQKRLQAE 2018

Query: 370  SQTHSFLHPSYYLYMCDKVVAPNVSLTSAVSQSKELT-----KTEASKSISRQSEKAHSS 424
             + H+F            V      L   + Q + +      + EA++  + ++E+A   
Sbjct: 2019 EKAHAFA-----------VQQKEQELQQTLQQEQSVLDQLRGEAEAARRAAEEAEEARVQ 2067

Query: 425  GKLQKTVSYPDVSLEEQEKMDLKTSRELCSRLDASISNNSTSKRKSESATCNLVRDINKV 484
             + +   S   V  EE E++      +  +R  A  +     K   + A      +  + 
Sbjct: 2068 AEREAAQSRRQV--EEAERLKQSAEEQAQARAQAQAAAEKLRKEAEQEAARRAQAE--QA 2123

Query: 485  GIGLVAAASSPLLVKDVICED---DKGKIMEEVMRTYLKQQE---KLNLILQKKQQL--- 535
             +    AA + +       E     K ++ +E+    L+ +E   + NL+ ++ Q+L   
Sbjct: 2124 ALRQKQAADAEMEKHKKFAEQTLRQKAQVEQELTTLRLQLEETDHQKNLLDEELQRLKAE 2183

Query: 536  ---------QMEVKMLSSSKSMKELTE-------------------EQQNLQKELESLQN 567
                     Q+E ++ S    M+EL++                    Q+ LQ+E E ++ 
Sbjct: 2184 ATEAARQRSQVEEELFSVRVQMEELSKLKARIEAENRALILRDKDNTQRFLQEEAEKMKQ 2243

Query: 568  --EHAQRMEEFYVEQKDLEKKLEQIMKQKCTCDSNLEKDK------------EAEYAGQL 613
              E A R+     E   L +  E+ + Q+      + K+K            EAE   Q 
Sbjct: 2244 VAEEAARLSVAAQEAARLRQLAEEDLAQQRALAEKMLKEKMQAVQEATRLKAEAELLQQQ 2303

Query: 614  AELRQ-RLDHAEADRQELQDELRQ---------EREARQKLEMM--IKELKLQILKSSK 660
             EL Q +    + D++++  +L +         E E +++LEM    + LKL++ + S+
Sbjct: 2304 KELAQEQARRLQEDKEQMAQQLAEETQGFQRTLEAERQRQLEMSAEAERLKLRVAEMSR 2362



 Score = 32.0 bits (71), Expect = 1.9
 Identities = 34/158 (21%), Positives = 73/158 (46%), Gaps = 24/158 (15%)

Query: 512  EEVMRTY---LKQQEKLNLILQKKQQLQMEVKMLSSSKSMKE-----LTEEQQNLQKELE 563
            EEV+R +   LK+ + +   L + +  +  +K L +    ++     L +E +  Q+  E
Sbjct: 1070 EEVLRAHEEQLKEAQAVPATLPELEATKASLKKLRAQAEAQQPTFDALRDELRGAQEVGE 1129

Query: 564  SLQNEHAQR---MEEFYVEQKDLEKKLEQIMKQKCTCDSNLEK-DKEAEYAGQ------- 612
             LQ  H +R   +E +      L ++ + ++ Q       LE+  ++  Y  +       
Sbjct: 1130 RLQQRHGERDVEVERWRERVAQLLERWQAVLAQTDVRQRELEQLGRQLRYYRESADPLGA 1189

Query: 613  -LAELRQRLDHAEA----DRQELQDELRQEREARQKLE 645
             L + R+R +  +A    D Q ++++LRQE+   +++E
Sbjct: 1190 WLQDARRRQEQIQAMPLADSQAVREQLRQEQALLEEIE 1227


>gi|41322916 plectin 1 isoform 6 [Homo sapiens]
          Length = 4684

 Score = 56.6 bits (135), Expect = 7e-08
 Identities = 59/270 (21%), Positives = 123/270 (45%), Gaps = 29/270 (10%)

Query: 399  VSQSKELTKTEASKSISRQSEKAHSSGKLQKTVSYPDVSLEEQEKMDLKTSRELCSRLDA 458
            + Q KEL + +A +    Q +K   + +L +       +LE + +  L+ S E   RL  
Sbjct: 2469 LQQQKELAQEQARRL---QEDKEQMAQQLAEETQGFQRTLEAERQRQLEMSAE-AERLKL 2524

Query: 459  SISNNSTSKRKSESATCNLVRDINKVGIGL----VAAASSPLLVKDVICEDDKGKIMEEV 514
             ++  S ++ ++E       +   ++G  L    +A      LV+ +  +  +     E 
Sbjct: 2525 RVAEMSRAQARAEEDAQRFRKQAEEIGEKLHRTELATQEKVTLVQTLEIQRQQSDHDAER 2584

Query: 515  MRTYLKQQEKLNLILQKKQQLQMEVKMLSSSKSMKELTEEQQNLQKELESLQNEHAQRME 574
            +R  + + E+      +K++LQ E K+L   KS +  T +Q+ L +E ++LQ       +
Sbjct: 2585 LREAIAELER------EKEKLQQEAKLLQL-KSEEMQTVQQEQLLQETQALQQSFLSEKD 2637

Query: 575  EFYVEQKDLEK---KLEQIMKQKCTCDSNLEKDKEAEY----------AGQLAELRQRLD 621
                 ++ +E+   KLEQ+ + +      L ++++ +              + E R+R  
Sbjct: 2638 SLLQRERFIEQEKAKLEQLFQDEVAKAQQLREEQQRQQQQMEQERQRLVASMEEARRRQH 2697

Query: 622  HAEADRQELQDELRQ-EREARQKLEMMIKE 650
             AE   +  Q+EL+Q E++ RQ+ E++ +E
Sbjct: 2698 EAEEGVRRKQEELQQLEQQRRQQEELLAEE 2727



 Score = 52.4 bits (124), Expect = 1e-06
 Identities = 68/284 (23%), Positives = 126/284 (44%), Gaps = 34/284 (11%)

Query: 400  SQSKELTKTEASKSISRQSEKAHSSGKLQKTVSYPDVSLEEQEKM----DLKTSRELCSR 455
            SQ K   + E +  +  ++E A    +  + +    +  EE E+     +++ +R++   
Sbjct: 1644 SQRKRQAEVELASRVKAEAEAAREKQRALQALEELRLQAEEAERRLRQAEVERARQVQVA 1703

Query: 456  LDA---SISNNSTSKRKS-ESATCNLVRDINK--VGIGLVAAASSPLLVKDVICEDDKGK 509
            L+    S      SKR S    T  L R + +  V +  +   +     +    E  + +
Sbjct: 1704 LETAQRSAEAELQSKRASFAEKTAQLERSLQEEHVAVAQLREEAERRAQQQAEAERAREE 1763

Query: 510  IMEEVMRTYLKQQEKLNLILQKKQQLQMEVKMLSSSKSMKELTEEQQNLQKELESLQNEH 569
               E+ R  LK  E L L LQ ++  Q         KS+ +   E+Q  + E E+ +   
Sbjct: 1764 AERELERWQLKANEALRLRLQAEEVAQQ--------KSLAQAEAEKQKEEAEREARRRGK 1815

Query: 570  AQRMEEFYVEQKDLEKKLEQIMKQKCTCDSNLEKDKEAEYAGQLAELRQRLDHAEADRQE 629
            A   EE  V Q++L +  +++ KQ+   +   ++   AE   +L  LR   +  E  RQ 
Sbjct: 1816 A---EEQAVRQRELAE--QELEKQRQLAEGTAQQRLAAEQ--ELIRLRAETEQGEQQRQL 1868

Query: 630  LQDEL-RQEREA------RQKLEMMIKELK--LQILKSSKTAKE 664
            L++EL R +REA      RQ+LE  + +++  +++L +SK   E
Sbjct: 1869 LEEELARLQREAAAATQKRQELEAELAKVRAEMEVLLASKARAE 1912



 Score = 44.3 bits (103), Expect = 4e-04
 Identities = 65/296 (21%), Positives = 123/296 (41%), Gaps = 43/296 (14%)

Query: 401  QSKELTKTEASKSISRQSEKAHSSGK---------LQKTVSYPDVSLEE------QEKMD 445
            + + L + EA+    RQ  +AH+  K         LQ+ +    V  EE      Q+K  
Sbjct: 1495 ERERLAEVEAALEKQRQLAEAHAQAKAQAEREAKELQQRMQEEVVRREEAAVDAQQQKRS 1554

Query: 446  LKTS-RELCSRLDASISNNSTSKRKSESATCNLVRDINKVGIGLVAAAS---------SP 495
            ++   ++L    +A I   +     +E +   +  +I  V + L A              
Sbjct: 1555 IQEELQQLRQSSEAEIQAKARQAEAAERSRLRIEEEIRVVRLQLEATERQRGGAEGELQA 1614

Query: 496  LLVKDVICEDDKGKIMEEVMRTYLKQQEKLNLILQKKQQLQMEVKMLSSSKSMKELTEEQ 555
            L  +    E  K +  EE  R   + Q+      + +++ Q EV++ S  K+  E   E+
Sbjct: 1615 LRARAEEAEAQKRQAQEEAERLRRQVQD------ESQRKRQAEVELASRVKAEAEAAREK 1668

Query: 556  QNLQKELES--LQNEHAQRMEEFYVEQKDLEKKLE-QIMKQKCTCDSNLE-KDKEAEYAG 611
            Q   + LE   LQ E A+R     + Q ++E+  + Q+  +     +  E + K A +A 
Sbjct: 1669 QRALQALEELRLQAEEAERR----LRQAEVERARQVQVALETAQRSAEAELQSKRASFAE 1724

Query: 612  QLAELRQRLDHAEAD----RQELQDELRQEREARQKLEMMIKELKLQILKSSKTAK 663
            + A+L + L          R+E +   +Q+ EA +  E   +EL+   LK+++  +
Sbjct: 1725 KTAQLERSLQEEHVAVAQLREEAERRAQQQAEAERAREEAERELERWQLKANEALR 1780



 Score = 38.1 bits (87), Expect = 0.026
 Identities = 28/140 (20%), Positives = 69/140 (49%), Gaps = 6/140 (4%)

Query: 531  KKQQLQMEVKMLSSSKSMKELTEEQQNLQKELESLQNEHAQRMEEFYVEQKDLEKKLEQI 590
            K+ Q +M+ +++   ++  +  ++++++Q+EL+ L+      ++    + +  E+   +I
Sbjct: 1528 KELQQRMQEEVVRREEAAVDAQQQKRSIQEELQQLRQSSEAEIQAKARQAEAAERSRLRI 1587

Query: 591  MKQKCTCDSNLEKDKEAEYA--GQLAELRQRLDHAEADRQELQDEL----RQEREARQKL 644
             ++       LE  +       G+L  LR R + AEA +++ Q+E     RQ ++  Q+ 
Sbjct: 1588 EEEIRVVRLQLEATERQRGGAEGELQALRARAEEAEAQKRQAQEEAERLRRQVQDESQRK 1647

Query: 645  EMMIKELKLQILKSSKTAKE 664
                 EL  ++   ++ A+E
Sbjct: 1648 RQAEVELASRVKAEAEAARE 1667



 Score = 37.7 bits (86), Expect = 0.034
 Identities = 41/161 (25%), Positives = 79/161 (49%), Gaps = 13/161 (8%)

Query: 496  LLVKDVICEDDKGKIMEEVMRTYLKQQEKLNLILQKKQQLQMEVKMLSSSKSMKELTEEQ 555
            LL ++   E +K K+ E++ +  + + ++L    Q++QQ QME +      SM+E    Q
Sbjct: 2639 LLQRERFIEQEKAKL-EQLFQDEVAKAQQLREEQQRQQQ-QMEQERQRLVASMEEARRRQ 2696

Query: 556  -------QNLQKELESLQNEHAQRMEEFYVEQKDLEKKLEQIMKQKCTCDSNLEKDKEAE 608
                   +  Q+EL+ L+ +  Q+ E    E + L ++L+ + +Q     ++ E+   ++
Sbjct: 2697 HEAEEGVRRKQEELQQLEQQRRQQEELLAEENQRLREQLQLLEEQHRAALAHSEEVTASQ 2756

Query: 609  YAG--QLAELRQRLD--HAEADRQELQDELRQEREARQKLE 645
             A    L   R  LD   AEA+ +   D LR++  A++  E
Sbjct: 2757 VAATKTLPNGRDALDGPAAEAEPEHSFDGLRRKVSAQRLQE 2797



 Score = 35.8 bits (81), Expect = 0.13
 Identities = 54/281 (19%), Positives = 116/281 (41%), Gaps = 36/281 (12%)

Query: 396  TSAVSQSKELTKTEASKSISRQSEKAHSSGKLQKTVSYPDVSLEEQEKMDLKTSRELCSR 455
            T    Q ++L + E ++    Q E A ++ K Q+  +       E  K+  +    L S+
Sbjct: 1859 TEQGEQQRQLLEEELARL---QREAAAATQKRQELEA-------ELAKVRAEMEVLLASK 1908

Query: 456  LDASISNNSTSKRKSE--SATCNLVRDINKVGIGLVAAASSPLLVKDVICEDDKGKIMEE 513
              A   + STS++  +   A     R++ +    L A A      +  + E+D  +   E
Sbjct: 1909 ARAEEESRSTSEKSKQRLEAEAGRFRELAEEAARLRALAEEAKRQRQ-LAEEDAARQRAE 1967

Query: 514  VMRTYLKQQEKLNLILQKKQQLQMEVKMLSS-SKSMKELTEEQQNLQKELESLQNEHAQR 572
              R   ++   +    + K + ++ +K   + ++ ++ L E++   ++ LE    +H   
Sbjct: 1968 AERVLAEKLAAIGEATRLKTEAEIALKEKEAENERLRRLAEDEAFQRRRLEEQAAQH--- 2024

Query: 573  MEEFYVEQKDLEKKLEQIMKQKCTCDSNLEKDK---------EAEYAGQLAELRQRLDHA 623
                   + D+E++L Q+ K     DS LE+ K           +   ++  L+   + A
Sbjct: 2025 -------KADIEERLAQLRK---ASDSELERQKGLVEDTLRQRRQVEEEILALKASFEKA 2074

Query: 624  EADRQELQDELRQEREARQKLEMMIKELKLQILKSSKTAKE 664
             A + EL+ EL + R   +      ++ +L+  +  + A E
Sbjct: 2075 AAGKAELELELGRIRSNAEDTLRSKEQAELEAARQRQLAAE 2115



 Score = 35.0 bits (79), Expect = 0.22
 Identities = 81/419 (19%), Positives = 162/419 (38%), Gaps = 86/419 (20%)

Query: 313  QKYLGTPEE--KKLKIILEEMKE-KFSMRSGKRNQSKTDAPSGMELQSWYPVIKQEGDHV 369
            QK L   EE  ++ K  LEE++  K  +   +R + + +  S  +LQ      ++     
Sbjct: 2128 QKSLAAEEEAARQRKAALEEVERLKAKVEEARRLRERAEQESARQLQLAQEAAQKRLQAE 2187

Query: 370  SQTHSFLHPSYYLYMCDKVVAPNVSLTSAVSQSKELT-----KTEASKSISRQSEKAHSS 424
             + H+F            V      L   + Q + +      + EA++  + ++E+A   
Sbjct: 2188 EKAHAFA-----------VQQKEQELQQTLQQEQSVLDQLRGEAEAARRAAEEAEEARVQ 2236

Query: 425  GKLQKTVSYPDVSLEEQEKMDLKTSRELCSRLDASISNNSTSKRKSESATCNLVRDINKV 484
             + +   S   V  EE E++      +  +R  A  +     K   + A      +  + 
Sbjct: 2237 AEREAAQSRRQV--EEAERLKQSAEEQAQARAQAQAAAEKLRKEAEQEAARRAQAE--QA 2292

Query: 485  GIGLVAAASSPLLVKDVICED---DKGKIMEEVMRTYLKQQE---KLNLILQKKQQL--- 535
             +    AA + +       E     K ++ +E+    L+ +E   + NL+ ++ Q+L   
Sbjct: 2293 ALRQKQAADAEMEKHKKFAEQTLRQKAQVEQELTTLRLQLEETDHQKNLLDEELQRLKAE 2352

Query: 536  ---------QMEVKMLSSSKSMKELTE-------------------EQQNLQKELESLQN 567
                     Q+E ++ S    M+EL++                    Q+ LQ+E E ++ 
Sbjct: 2353 ATEAARQRSQVEEELFSVRVQMEELSKLKARIEAENRALILRDKDNTQRFLQEEAEKMKQ 2412

Query: 568  --EHAQRMEEFYVEQKDLEKKLEQIMKQKCTCDSNLEKDK------------EAEYAGQL 613
              E A R+     E   L +  E+ + Q+      + K+K            EAE   Q 
Sbjct: 2413 VAEEAARLSVAAQEAARLRQLAEEDLAQQRALAEKMLKEKMQAVQEATRLKAEAELLQQQ 2472

Query: 614  AELRQ-RLDHAEADRQELQDELRQ---------EREARQKLEMM--IKELKLQILKSSK 660
             EL Q +    + D++++  +L +         E E +++LEM    + LKL++ + S+
Sbjct: 2473 KELAQEQARRLQEDKEQMAQQLAEETQGFQRTLEAERQRQLEMSAEAERLKLRVAEMSR 2531



 Score = 32.0 bits (71), Expect = 1.9
 Identities = 34/158 (21%), Positives = 73/158 (46%), Gaps = 24/158 (15%)

Query: 512  EEVMRTY---LKQQEKLNLILQKKQQLQMEVKMLSSSKSMKE-----LTEEQQNLQKELE 563
            EEV+R +   LK+ + +   L + +  +  +K L +    ++     L +E +  Q+  E
Sbjct: 1239 EEVLRAHEEQLKEAQAVPATLPELEATKASLKKLRAQAEAQQPTFDALRDELRGAQEVGE 1298

Query: 564  SLQNEHAQR---MEEFYVEQKDLEKKLEQIMKQKCTCDSNLEK-DKEAEYAGQ------- 612
             LQ  H +R   +E +      L ++ + ++ Q       LE+  ++  Y  +       
Sbjct: 1299 RLQQRHGERDVEVERWRERVAQLLERWQAVLAQTDVRQRELEQLGRQLRYYRESADPLGA 1358

Query: 613  -LAELRQRLDHAEA----DRQELQDELRQEREARQKLE 645
             L + R+R +  +A    D Q ++++LRQE+   +++E
Sbjct: 1359 WLQDARRRQEQIQAMPLADSQAVREQLRQEQALLEEIE 1396


>gi|41322908 plectin 1 isoform 3 [Homo sapiens]
          Length = 4525

 Score = 56.6 bits (135), Expect = 7e-08
 Identities = 59/270 (21%), Positives = 123/270 (45%), Gaps = 29/270 (10%)

Query: 399  VSQSKELTKTEASKSISRQSEKAHSSGKLQKTVSYPDVSLEEQEKMDLKTSRELCSRLDA 458
            + Q KEL + +A +    Q +K   + +L +       +LE + +  L+ S E   RL  
Sbjct: 2310 LQQQKELAQEQARRL---QEDKEQMAQQLAEETQGFQRTLEAERQRQLEMSAE-AERLKL 2365

Query: 459  SISNNSTSKRKSESATCNLVRDINKVGIGL----VAAASSPLLVKDVICEDDKGKIMEEV 514
             ++  S ++ ++E       +   ++G  L    +A      LV+ +  +  +     E 
Sbjct: 2366 RVAEMSRAQARAEEDAQRFRKQAEEIGEKLHRTELATQEKVTLVQTLEIQRQQSDHDAER 2425

Query: 515  MRTYLKQQEKLNLILQKKQQLQMEVKMLSSSKSMKELTEEQQNLQKELESLQNEHAQRME 574
            +R  + + E+      +K++LQ E K+L   KS +  T +Q+ L +E ++LQ       +
Sbjct: 2426 LREAIAELER------EKEKLQQEAKLLQL-KSEEMQTVQQEQLLQETQALQQSFLSEKD 2478

Query: 575  EFYVEQKDLEK---KLEQIMKQKCTCDSNLEKDKEAEY----------AGQLAELRQRLD 621
                 ++ +E+   KLEQ+ + +      L ++++ +              + E R+R  
Sbjct: 2479 SLLQRERFIEQEKAKLEQLFQDEVAKAQQLREEQQRQQQQMEQERQRLVASMEEARRRQH 2538

Query: 622  HAEADRQELQDELRQ-EREARQKLEMMIKE 650
             AE   +  Q+EL+Q E++ RQ+ E++ +E
Sbjct: 2539 EAEEGVRRKQEELQQLEQQRRQQEELLAEE 2568



 Score = 52.4 bits (124), Expect = 1e-06
 Identities = 68/284 (23%), Positives = 126/284 (44%), Gaps = 34/284 (11%)

Query: 400  SQSKELTKTEASKSISRQSEKAHSSGKLQKTVSYPDVSLEEQEKM----DLKTSRELCSR 455
            SQ K   + E +  +  ++E A    +  + +    +  EE E+     +++ +R++   
Sbjct: 1485 SQRKRQAEVELASRVKAEAEAAREKQRALQALEELRLQAEEAERRLRQAEVERARQVQVA 1544

Query: 456  LDA---SISNNSTSKRKS-ESATCNLVRDINK--VGIGLVAAASSPLLVKDVICEDDKGK 509
            L+    S      SKR S    T  L R + +  V +  +   +     +    E  + +
Sbjct: 1545 LETAQRSAEAELQSKRASFAEKTAQLERSLQEEHVAVAQLREEAERRAQQQAEAERAREE 1604

Query: 510  IMEEVMRTYLKQQEKLNLILQKKQQLQMEVKMLSSSKSMKELTEEQQNLQKELESLQNEH 569
               E+ R  LK  E L L LQ ++  Q         KS+ +   E+Q  + E E+ +   
Sbjct: 1605 AERELERWQLKANEALRLRLQAEEVAQQ--------KSLAQAEAEKQKEEAEREARRRGK 1656

Query: 570  AQRMEEFYVEQKDLEKKLEQIMKQKCTCDSNLEKDKEAEYAGQLAELRQRLDHAEADRQE 629
            A   EE  V Q++L +  +++ KQ+   +   ++   AE   +L  LR   +  E  RQ 
Sbjct: 1657 A---EEQAVRQRELAE--QELEKQRQLAEGTAQQRLAAEQ--ELIRLRAETEQGEQQRQL 1709

Query: 630  LQDEL-RQEREA------RQKLEMMIKELK--LQILKSSKTAKE 664
            L++EL R +REA      RQ+LE  + +++  +++L +SK   E
Sbjct: 1710 LEEELARLQREAAAATQKRQELEAELAKVRAEMEVLLASKARAE 1753



 Score = 44.3 bits (103), Expect = 4e-04
 Identities = 65/296 (21%), Positives = 123/296 (41%), Gaps = 43/296 (14%)

Query: 401  QSKELTKTEASKSISRQSEKAHSSGK---------LQKTVSYPDVSLEE------QEKMD 445
            + + L + EA+    RQ  +AH+  K         LQ+ +    V  EE      Q+K  
Sbjct: 1336 ERERLAEVEAALEKQRQLAEAHAQAKAQAEREAKELQQRMQEEVVRREEAAVDAQQQKRS 1395

Query: 446  LKTS-RELCSRLDASISNNSTSKRKSESATCNLVRDINKVGIGLVAAAS---------SP 495
            ++   ++L    +A I   +     +E +   +  +I  V + L A              
Sbjct: 1396 IQEELQQLRQSSEAEIQAKARQAEAAERSRLRIEEEIRVVRLQLEATERQRGGAEGELQA 1455

Query: 496  LLVKDVICEDDKGKIMEEVMRTYLKQQEKLNLILQKKQQLQMEVKMLSSSKSMKELTEEQ 555
            L  +    E  K +  EE  R   + Q+      + +++ Q EV++ S  K+  E   E+
Sbjct: 1456 LRARAEEAEAQKRQAQEEAERLRRQVQD------ESQRKRQAEVELASRVKAEAEAAREK 1509

Query: 556  QNLQKELES--LQNEHAQRMEEFYVEQKDLEKKLE-QIMKQKCTCDSNLE-KDKEAEYAG 611
            Q   + LE   LQ E A+R     + Q ++E+  + Q+  +     +  E + K A +A 
Sbjct: 1510 QRALQALEELRLQAEEAERR----LRQAEVERARQVQVALETAQRSAEAELQSKRASFAE 1565

Query: 612  QLAELRQRLDHAEAD----RQELQDELRQEREARQKLEMMIKELKLQILKSSKTAK 663
            + A+L + L          R+E +   +Q+ EA +  E   +EL+   LK+++  +
Sbjct: 1566 KTAQLERSLQEEHVAVAQLREEAERRAQQQAEAERAREEAERELERWQLKANEALR 1621



 Score = 38.1 bits (87), Expect = 0.026
 Identities = 28/140 (20%), Positives = 69/140 (49%), Gaps = 6/140 (4%)

Query: 531  KKQQLQMEVKMLSSSKSMKELTEEQQNLQKELESLQNEHAQRMEEFYVEQKDLEKKLEQI 590
            K+ Q +M+ +++   ++  +  ++++++Q+EL+ L+      ++    + +  E+   +I
Sbjct: 1369 KELQQRMQEEVVRREEAAVDAQQQKRSIQEELQQLRQSSEAEIQAKARQAEAAERSRLRI 1428

Query: 591  MKQKCTCDSNLEKDKEAEYA--GQLAELRQRLDHAEADRQELQDEL----RQEREARQKL 644
             ++       LE  +       G+L  LR R + AEA +++ Q+E     RQ ++  Q+ 
Sbjct: 1429 EEEIRVVRLQLEATERQRGGAEGELQALRARAEEAEAQKRQAQEEAERLRRQVQDESQRK 1488

Query: 645  EMMIKELKLQILKSSKTAKE 664
                 EL  ++   ++ A+E
Sbjct: 1489 RQAEVELASRVKAEAEAARE 1508



 Score = 37.7 bits (86), Expect = 0.034
 Identities = 41/161 (25%), Positives = 79/161 (49%), Gaps = 13/161 (8%)

Query: 496  LLVKDVICEDDKGKIMEEVMRTYLKQQEKLNLILQKKQQLQMEVKMLSSSKSMKELTEEQ 555
            LL ++   E +K K+ E++ +  + + ++L    Q++QQ QME +      SM+E    Q
Sbjct: 2480 LLQRERFIEQEKAKL-EQLFQDEVAKAQQLREEQQRQQQ-QMEQERQRLVASMEEARRRQ 2537

Query: 556  -------QNLQKELESLQNEHAQRMEEFYVEQKDLEKKLEQIMKQKCTCDSNLEKDKEAE 608
                   +  Q+EL+ L+ +  Q+ E    E + L ++L+ + +Q     ++ E+   ++
Sbjct: 2538 HEAEEGVRRKQEELQQLEQQRRQQEELLAEENQRLREQLQLLEEQHRAALAHSEEVTASQ 2597

Query: 609  YAG--QLAELRQRLD--HAEADRQELQDELRQEREARQKLE 645
             A    L   R  LD   AEA+ +   D LR++  A++  E
Sbjct: 2598 VAATKTLPNGRDALDGPAAEAEPEHSFDGLRRKVSAQRLQE 2638



 Score = 35.8 bits (81), Expect = 0.13
 Identities = 54/281 (19%), Positives = 116/281 (41%), Gaps = 36/281 (12%)

Query: 396  TSAVSQSKELTKTEASKSISRQSEKAHSSGKLQKTVSYPDVSLEEQEKMDLKTSRELCSR 455
            T    Q ++L + E ++    Q E A ++ K Q+  +       E  K+  +    L S+
Sbjct: 1700 TEQGEQQRQLLEEELARL---QREAAAATQKRQELEA-------ELAKVRAEMEVLLASK 1749

Query: 456  LDASISNNSTSKRKSE--SATCNLVRDINKVGIGLVAAASSPLLVKDVICEDDKGKIMEE 513
              A   + STS++  +   A     R++ +    L A A      +  + E+D  +   E
Sbjct: 1750 ARAEEESRSTSEKSKQRLEAEAGRFRELAEEAARLRALAEEAKRQRQ-LAEEDAARQRAE 1808

Query: 514  VMRTYLKQQEKLNLILQKKQQLQMEVKMLSS-SKSMKELTEEQQNLQKELESLQNEHAQR 572
              R   ++   +    + K + ++ +K   + ++ ++ L E++   ++ LE    +H   
Sbjct: 1809 AERVLAEKLAAIGEATRLKTEAEIALKEKEAENERLRRLAEDEAFQRRRLEEQAAQH--- 1865

Query: 573  MEEFYVEQKDLEKKLEQIMKQKCTCDSNLEKDK---------EAEYAGQLAELRQRLDHA 623
                   + D+E++L Q+ K     DS LE+ K           +   ++  L+   + A
Sbjct: 1866 -------KADIEERLAQLRK---ASDSELERQKGLVEDTLRQRRQVEEEILALKASFEKA 1915

Query: 624  EADRQELQDELRQEREARQKLEMMIKELKLQILKSSKTAKE 664
             A + EL+ EL + R   +      ++ +L+  +  + A E
Sbjct: 1916 AAGKAELELELGRIRSNAEDTLRSKEQAELEAARQRQLAAE 1956



 Score = 35.0 bits (79), Expect = 0.22
 Identities = 81/419 (19%), Positives = 162/419 (38%), Gaps = 86/419 (20%)

Query: 313  QKYLGTPEE--KKLKIILEEMKE-KFSMRSGKRNQSKTDAPSGMELQSWYPVIKQEGDHV 369
            QK L   EE  ++ K  LEE++  K  +   +R + + +  S  +LQ      ++     
Sbjct: 1969 QKSLAAEEEAARQRKAALEEVERLKAKVEEARRLRERAEQESARQLQLAQEAAQKRLQAE 2028

Query: 370  SQTHSFLHPSYYLYMCDKVVAPNVSLTSAVSQSKELT-----KTEASKSISRQSEKAHSS 424
             + H+F            V      L   + Q + +      + EA++  + ++E+A   
Sbjct: 2029 EKAHAFA-----------VQQKEQELQQTLQQEQSVLDQLRGEAEAARRAAEEAEEARVQ 2077

Query: 425  GKLQKTVSYPDVSLEEQEKMDLKTSRELCSRLDASISNNSTSKRKSESATCNLVRDINKV 484
             + +   S   V  EE E++      +  +R  A  +     K   + A      +  + 
Sbjct: 2078 AEREAAQSRRQV--EEAERLKQSAEEQAQARAQAQAAAEKLRKEAEQEAARRAQAE--QA 2133

Query: 485  GIGLVAAASSPLLVKDVICED---DKGKIMEEVMRTYLKQQE---KLNLILQKKQQL--- 535
             +    AA + +       E     K ++ +E+    L+ +E   + NL+ ++ Q+L   
Sbjct: 2134 ALRQKQAADAEMEKHKKFAEQTLRQKAQVEQELTTLRLQLEETDHQKNLLDEELQRLKAE 2193

Query: 536  ---------QMEVKMLSSSKSMKELTE-------------------EQQNLQKELESLQN 567
                     Q+E ++ S    M+EL++                    Q+ LQ+E E ++ 
Sbjct: 2194 ATEAARQRSQVEEELFSVRVQMEELSKLKARIEAENRALILRDKDNTQRFLQEEAEKMKQ 2253

Query: 568  --EHAQRMEEFYVEQKDLEKKLEQIMKQKCTCDSNLEKDK------------EAEYAGQL 613
              E A R+     E   L +  E+ + Q+      + K+K            EAE   Q 
Sbjct: 2254 VAEEAARLSVAAQEAARLRQLAEEDLAQQRALAEKMLKEKMQAVQEATRLKAEAELLQQQ 2313

Query: 614  AELRQ-RLDHAEADRQELQDELRQ---------EREARQKLEMM--IKELKLQILKSSK 660
             EL Q +    + D++++  +L +         E E +++LEM    + LKL++ + S+
Sbjct: 2314 KELAQEQARRLQEDKEQMAQQLAEETQGFQRTLEAERQRQLEMSAEAERLKLRVAEMSR 2372



 Score = 32.0 bits (71), Expect = 1.9
 Identities = 34/158 (21%), Positives = 73/158 (46%), Gaps = 24/158 (15%)

Query: 512  EEVMRTY---LKQQEKLNLILQKKQQLQMEVKMLSSSKSMKE-----LTEEQQNLQKELE 563
            EEV+R +   LK+ + +   L + +  +  +K L +    ++     L +E +  Q+  E
Sbjct: 1080 EEVLRAHEEQLKEAQAVPATLPELEATKASLKKLRAQAEAQQPTFDALRDELRGAQEVGE 1139

Query: 564  SLQNEHAQR---MEEFYVEQKDLEKKLEQIMKQKCTCDSNLEK-DKEAEYAGQ------- 612
             LQ  H +R   +E +      L ++ + ++ Q       LE+  ++  Y  +       
Sbjct: 1140 RLQQRHGERDVEVERWRERVAQLLERWQAVLAQTDVRQRELEQLGRQLRYYRESADPLGA 1199

Query: 613  -LAELRQRLDHAEA----DRQELQDELRQEREARQKLE 645
             L + R+R +  +A    D Q ++++LRQE+   +++E
Sbjct: 1200 WLQDARRRQEQIQAMPLADSQAVREQLRQEQALLEEIE 1237


>gi|41322912 plectin 1 isoform 2 [Homo sapiens]
          Length = 4533

 Score = 56.6 bits (135), Expect = 7e-08
 Identities = 59/270 (21%), Positives = 123/270 (45%), Gaps = 29/270 (10%)

Query: 399  VSQSKELTKTEASKSISRQSEKAHSSGKLQKTVSYPDVSLEEQEKMDLKTSRELCSRLDA 458
            + Q KEL + +A +    Q +K   + +L +       +LE + +  L+ S E   RL  
Sbjct: 2318 LQQQKELAQEQARRL---QEDKEQMAQQLAEETQGFQRTLEAERQRQLEMSAE-AERLKL 2373

Query: 459  SISNNSTSKRKSESATCNLVRDINKVGIGL----VAAASSPLLVKDVICEDDKGKIMEEV 514
             ++  S ++ ++E       +   ++G  L    +A      LV+ +  +  +     E 
Sbjct: 2374 RVAEMSRAQARAEEDAQRFRKQAEEIGEKLHRTELATQEKVTLVQTLEIQRQQSDHDAER 2433

Query: 515  MRTYLKQQEKLNLILQKKQQLQMEVKMLSSSKSMKELTEEQQNLQKELESLQNEHAQRME 574
            +R  + + E+      +K++LQ E K+L   KS +  T +Q+ L +E ++LQ       +
Sbjct: 2434 LREAIAELER------EKEKLQQEAKLLQL-KSEEMQTVQQEQLLQETQALQQSFLSEKD 2486

Query: 575  EFYVEQKDLEK---KLEQIMKQKCTCDSNLEKDKEAEY----------AGQLAELRQRLD 621
                 ++ +E+   KLEQ+ + +      L ++++ +              + E R+R  
Sbjct: 2487 SLLQRERFIEQEKAKLEQLFQDEVAKAQQLREEQQRQQQQMEQERQRLVASMEEARRRQH 2546

Query: 622  HAEADRQELQDELRQ-EREARQKLEMMIKE 650
             AE   +  Q+EL+Q E++ RQ+ E++ +E
Sbjct: 2547 EAEEGVRRKQEELQQLEQQRRQQEELLAEE 2576



 Score = 52.4 bits (124), Expect = 1e-06
 Identities = 68/284 (23%), Positives = 126/284 (44%), Gaps = 34/284 (11%)

Query: 400  SQSKELTKTEASKSISRQSEKAHSSGKLQKTVSYPDVSLEEQEKM----DLKTSRELCSR 455
            SQ K   + E +  +  ++E A    +  + +    +  EE E+     +++ +R++   
Sbjct: 1493 SQRKRQAEVELASRVKAEAEAAREKQRALQALEELRLQAEEAERRLRQAEVERARQVQVA 1552

Query: 456  LDA---SISNNSTSKRKS-ESATCNLVRDINK--VGIGLVAAASSPLLVKDVICEDDKGK 509
            L+    S      SKR S    T  L R + +  V +  +   +     +    E  + +
Sbjct: 1553 LETAQRSAEAELQSKRASFAEKTAQLERSLQEEHVAVAQLREEAERRAQQQAEAERAREE 1612

Query: 510  IMEEVMRTYLKQQEKLNLILQKKQQLQMEVKMLSSSKSMKELTEEQQNLQKELESLQNEH 569
               E+ R  LK  E L L LQ ++  Q         KS+ +   E+Q  + E E+ +   
Sbjct: 1613 AERELERWQLKANEALRLRLQAEEVAQQ--------KSLAQAEAEKQKEEAEREARRRGK 1664

Query: 570  AQRMEEFYVEQKDLEKKLEQIMKQKCTCDSNLEKDKEAEYAGQLAELRQRLDHAEADRQE 629
            A   EE  V Q++L +  +++ KQ+   +   ++   AE   +L  LR   +  E  RQ 
Sbjct: 1665 A---EEQAVRQRELAE--QELEKQRQLAEGTAQQRLAAEQ--ELIRLRAETEQGEQQRQL 1717

Query: 630  LQDEL-RQEREA------RQKLEMMIKELK--LQILKSSKTAKE 664
            L++EL R +REA      RQ+LE  + +++  +++L +SK   E
Sbjct: 1718 LEEELARLQREAAAATQKRQELEAELAKVRAEMEVLLASKARAE 1761



 Score = 44.3 bits (103), Expect = 4e-04
 Identities = 65/296 (21%), Positives = 123/296 (41%), Gaps = 43/296 (14%)

Query: 401  QSKELTKTEASKSISRQSEKAHSSGK---------LQKTVSYPDVSLEE------QEKMD 445
            + + L + EA+    RQ  +AH+  K         LQ+ +    V  EE      Q+K  
Sbjct: 1344 ERERLAEVEAALEKQRQLAEAHAQAKAQAEREAKELQQRMQEEVVRREEAAVDAQQQKRS 1403

Query: 446  LKTS-RELCSRLDASISNNSTSKRKSESATCNLVRDINKVGIGLVAAAS---------SP 495
            ++   ++L    +A I   +     +E +   +  +I  V + L A              
Sbjct: 1404 IQEELQQLRQSSEAEIQAKARQAEAAERSRLRIEEEIRVVRLQLEATERQRGGAEGELQA 1463

Query: 496  LLVKDVICEDDKGKIMEEVMRTYLKQQEKLNLILQKKQQLQMEVKMLSSSKSMKELTEEQ 555
            L  +    E  K +  EE  R   + Q+      + +++ Q EV++ S  K+  E   E+
Sbjct: 1464 LRARAEEAEAQKRQAQEEAERLRRQVQD------ESQRKRQAEVELASRVKAEAEAAREK 1517

Query: 556  QNLQKELES--LQNEHAQRMEEFYVEQKDLEKKLE-QIMKQKCTCDSNLE-KDKEAEYAG 611
            Q   + LE   LQ E A+R     + Q ++E+  + Q+  +     +  E + K A +A 
Sbjct: 1518 QRALQALEELRLQAEEAERR----LRQAEVERARQVQVALETAQRSAEAELQSKRASFAE 1573

Query: 612  QLAELRQRLDHAEAD----RQELQDELRQEREARQKLEMMIKELKLQILKSSKTAK 663
            + A+L + L          R+E +   +Q+ EA +  E   +EL+   LK+++  +
Sbjct: 1574 KTAQLERSLQEEHVAVAQLREEAERRAQQQAEAERAREEAERELERWQLKANEALR 1629



 Score = 38.1 bits (87), Expect = 0.026
 Identities = 28/140 (20%), Positives = 69/140 (49%), Gaps = 6/140 (4%)

Query: 531  KKQQLQMEVKMLSSSKSMKELTEEQQNLQKELESLQNEHAQRMEEFYVEQKDLEKKLEQI 590
            K+ Q +M+ +++   ++  +  ++++++Q+EL+ L+      ++    + +  E+   +I
Sbjct: 1377 KELQQRMQEEVVRREEAAVDAQQQKRSIQEELQQLRQSSEAEIQAKARQAEAAERSRLRI 1436

Query: 591  MKQKCTCDSNLEKDKEAEYA--GQLAELRQRLDHAEADRQELQDEL----RQEREARQKL 644
             ++       LE  +       G+L  LR R + AEA +++ Q+E     RQ ++  Q+ 
Sbjct: 1437 EEEIRVVRLQLEATERQRGGAEGELQALRARAEEAEAQKRQAQEEAERLRRQVQDESQRK 1496

Query: 645  EMMIKELKLQILKSSKTAKE 664
                 EL  ++   ++ A+E
Sbjct: 1497 RQAEVELASRVKAEAEAARE 1516



 Score = 37.7 bits (86), Expect = 0.034
 Identities = 41/161 (25%), Positives = 79/161 (49%), Gaps = 13/161 (8%)

Query: 496  LLVKDVICEDDKGKIMEEVMRTYLKQQEKLNLILQKKQQLQMEVKMLSSSKSMKELTEEQ 555
            LL ++   E +K K+ E++ +  + + ++L    Q++QQ QME +      SM+E    Q
Sbjct: 2488 LLQRERFIEQEKAKL-EQLFQDEVAKAQQLREEQQRQQQ-QMEQERQRLVASMEEARRRQ 2545

Query: 556  -------QNLQKELESLQNEHAQRMEEFYVEQKDLEKKLEQIMKQKCTCDSNLEKDKEAE 608
                   +  Q+EL+ L+ +  Q+ E    E + L ++L+ + +Q     ++ E+   ++
Sbjct: 2546 HEAEEGVRRKQEELQQLEQQRRQQEELLAEENQRLREQLQLLEEQHRAALAHSEEVTASQ 2605

Query: 609  YAG--QLAELRQRLD--HAEADRQELQDELRQEREARQKLE 645
             A    L   R  LD   AEA+ +   D LR++  A++  E
Sbjct: 2606 VAATKTLPNGRDALDGPAAEAEPEHSFDGLRRKVSAQRLQE 2646



 Score = 35.8 bits (81), Expect = 0.13
 Identities = 54/281 (19%), Positives = 116/281 (41%), Gaps = 36/281 (12%)

Query: 396  TSAVSQSKELTKTEASKSISRQSEKAHSSGKLQKTVSYPDVSLEEQEKMDLKTSRELCSR 455
            T    Q ++L + E ++    Q E A ++ K Q+  +       E  K+  +    L S+
Sbjct: 1708 TEQGEQQRQLLEEELARL---QREAAAATQKRQELEA-------ELAKVRAEMEVLLASK 1757

Query: 456  LDASISNNSTSKRKSE--SATCNLVRDINKVGIGLVAAASSPLLVKDVICEDDKGKIMEE 513
              A   + STS++  +   A     R++ +    L A A      +  + E+D  +   E
Sbjct: 1758 ARAEEESRSTSEKSKQRLEAEAGRFRELAEEAARLRALAEEAKRQRQ-LAEEDAARQRAE 1816

Query: 514  VMRTYLKQQEKLNLILQKKQQLQMEVKMLSS-SKSMKELTEEQQNLQKELESLQNEHAQR 572
              R   ++   +    + K + ++ +K   + ++ ++ L E++   ++ LE    +H   
Sbjct: 1817 AERVLAEKLAAIGEATRLKTEAEIALKEKEAENERLRRLAEDEAFQRRRLEEQAAQH--- 1873

Query: 573  MEEFYVEQKDLEKKLEQIMKQKCTCDSNLEKDK---------EAEYAGQLAELRQRLDHA 623
                   + D+E++L Q+ K     DS LE+ K           +   ++  L+   + A
Sbjct: 1874 -------KADIEERLAQLRK---ASDSELERQKGLVEDTLRQRRQVEEEILALKASFEKA 1923

Query: 624  EADRQELQDELRQEREARQKLEMMIKELKLQILKSSKTAKE 664
             A + EL+ EL + R   +      ++ +L+  +  + A E
Sbjct: 1924 AAGKAELELELGRIRSNAEDTLRSKEQAELEAARQRQLAAE 1964



 Score = 35.0 bits (79), Expect = 0.22
 Identities = 81/419 (19%), Positives = 162/419 (38%), Gaps = 86/419 (20%)

Query: 313  QKYLGTPEE--KKLKIILEEMKE-KFSMRSGKRNQSKTDAPSGMELQSWYPVIKQEGDHV 369
            QK L   EE  ++ K  LEE++  K  +   +R + + +  S  +LQ      ++     
Sbjct: 1977 QKSLAAEEEAARQRKAALEEVERLKAKVEEARRLRERAEQESARQLQLAQEAAQKRLQAE 2036

Query: 370  SQTHSFLHPSYYLYMCDKVVAPNVSLTSAVSQSKELT-----KTEASKSISRQSEKAHSS 424
             + H+F            V      L   + Q + +      + EA++  + ++E+A   
Sbjct: 2037 EKAHAFA-----------VQQKEQELQQTLQQEQSVLDQLRGEAEAARRAAEEAEEARVQ 2085

Query: 425  GKLQKTVSYPDVSLEEQEKMDLKTSRELCSRLDASISNNSTSKRKSESATCNLVRDINKV 484
             + +   S   V  EE E++      +  +R  A  +     K   + A      +  + 
Sbjct: 2086 AEREAAQSRRQV--EEAERLKQSAEEQAQARAQAQAAAEKLRKEAEQEAARRAQAE--QA 2141

Query: 485  GIGLVAAASSPLLVKDVICED---DKGKIMEEVMRTYLKQQE---KLNLILQKKQQL--- 535
             +    AA + +       E     K ++ +E+    L+ +E   + NL+ ++ Q+L   
Sbjct: 2142 ALRQKQAADAEMEKHKKFAEQTLRQKAQVEQELTTLRLQLEETDHQKNLLDEELQRLKAE 2201

Query: 536  ---------QMEVKMLSSSKSMKELTE-------------------EQQNLQKELESLQN 567
                     Q+E ++ S    M+EL++                    Q+ LQ+E E ++ 
Sbjct: 2202 ATEAARQRSQVEEELFSVRVQMEELSKLKARIEAENRALILRDKDNTQRFLQEEAEKMKQ 2261

Query: 568  --EHAQRMEEFYVEQKDLEKKLEQIMKQKCTCDSNLEKDK------------EAEYAGQL 613
              E A R+     E   L +  E+ + Q+      + K+K            EAE   Q 
Sbjct: 2262 VAEEAARLSVAAQEAARLRQLAEEDLAQQRALAEKMLKEKMQAVQEATRLKAEAELLQQQ 2321

Query: 614  AELRQ-RLDHAEADRQELQDELRQ---------EREARQKLEMM--IKELKLQILKSSK 660
             EL Q +    + D++++  +L +         E E +++LEM    + LKL++ + S+
Sbjct: 2322 KELAQEQARRLQEDKEQMAQQLAEETQGFQRTLEAERQRQLEMSAEAERLKLRVAEMSR 2380



 Score = 32.0 bits (71), Expect = 1.9
 Identities = 34/158 (21%), Positives = 73/158 (46%), Gaps = 24/158 (15%)

Query: 512  EEVMRTY---LKQQEKLNLILQKKQQLQMEVKMLSSSKSMKE-----LTEEQQNLQKELE 563
            EEV+R +   LK+ + +   L + +  +  +K L +    ++     L +E +  Q+  E
Sbjct: 1088 EEVLRAHEEQLKEAQAVPATLPELEATKASLKKLRAQAEAQQPTFDALRDELRGAQEVGE 1147

Query: 564  SLQNEHAQR---MEEFYVEQKDLEKKLEQIMKQKCTCDSNLEK-DKEAEYAGQ------- 612
             LQ  H +R   +E +      L ++ + ++ Q       LE+  ++  Y  +       
Sbjct: 1148 RLQQRHGERDVEVERWRERVAQLLERWQAVLAQTDVRQRELEQLGRQLRYYRESADPLGA 1207

Query: 613  -LAELRQRLDHAEA----DRQELQDELRQEREARQKLE 645
             L + R+R +  +A    D Q ++++LRQE+   +++E
Sbjct: 1208 WLQDARRRQEQIQAMPLADSQAVREQLRQEQALLEEIE 1245


>gi|47607492 plectin 1 isoform 1 [Homo sapiens]
          Length = 4574

 Score = 56.6 bits (135), Expect = 7e-08
 Identities = 59/270 (21%), Positives = 123/270 (45%), Gaps = 29/270 (10%)

Query: 399  VSQSKELTKTEASKSISRQSEKAHSSGKLQKTVSYPDVSLEEQEKMDLKTSRELCSRLDA 458
            + Q KEL + +A +    Q +K   + +L +       +LE + +  L+ S E   RL  
Sbjct: 2359 LQQQKELAQEQARRL---QEDKEQMAQQLAEETQGFQRTLEAERQRQLEMSAE-AERLKL 2414

Query: 459  SISNNSTSKRKSESATCNLVRDINKVGIGL----VAAASSPLLVKDVICEDDKGKIMEEV 514
             ++  S ++ ++E       +   ++G  L    +A      LV+ +  +  +     E 
Sbjct: 2415 RVAEMSRAQARAEEDAQRFRKQAEEIGEKLHRTELATQEKVTLVQTLEIQRQQSDHDAER 2474

Query: 515  MRTYLKQQEKLNLILQKKQQLQMEVKMLSSSKSMKELTEEQQNLQKELESLQNEHAQRME 574
            +R  + + E+      +K++LQ E K+L   KS +  T +Q+ L +E ++LQ       +
Sbjct: 2475 LREAIAELER------EKEKLQQEAKLLQL-KSEEMQTVQQEQLLQETQALQQSFLSEKD 2527

Query: 575  EFYVEQKDLEK---KLEQIMKQKCTCDSNLEKDKEAEY----------AGQLAELRQRLD 621
                 ++ +E+   KLEQ+ + +      L ++++ +              + E R+R  
Sbjct: 2528 SLLQRERFIEQEKAKLEQLFQDEVAKAQQLREEQQRQQQQMEQERQRLVASMEEARRRQH 2587

Query: 622  HAEADRQELQDELRQ-EREARQKLEMMIKE 650
             AE   +  Q+EL+Q E++ RQ+ E++ +E
Sbjct: 2588 EAEEGVRRKQEELQQLEQQRRQQEELLAEE 2617



 Score = 52.4 bits (124), Expect = 1e-06
 Identities = 68/284 (23%), Positives = 126/284 (44%), Gaps = 34/284 (11%)

Query: 400  SQSKELTKTEASKSISRQSEKAHSSGKLQKTVSYPDVSLEEQEKM----DLKTSRELCSR 455
            SQ K   + E +  +  ++E A    +  + +    +  EE E+     +++ +R++   
Sbjct: 1534 SQRKRQAEVELASRVKAEAEAAREKQRALQALEELRLQAEEAERRLRQAEVERARQVQVA 1593

Query: 456  LDA---SISNNSTSKRKS-ESATCNLVRDINK--VGIGLVAAASSPLLVKDVICEDDKGK 509
            L+    S      SKR S    T  L R + +  V +  +   +     +    E  + +
Sbjct: 1594 LETAQRSAEAELQSKRASFAEKTAQLERSLQEEHVAVAQLREEAERRAQQQAEAERAREE 1653

Query: 510  IMEEVMRTYLKQQEKLNLILQKKQQLQMEVKMLSSSKSMKELTEEQQNLQKELESLQNEH 569
               E+ R  LK  E L L LQ ++  Q         KS+ +   E+Q  + E E+ +   
Sbjct: 1654 AERELERWQLKANEALRLRLQAEEVAQQ--------KSLAQAEAEKQKEEAEREARRRGK 1705

Query: 570  AQRMEEFYVEQKDLEKKLEQIMKQKCTCDSNLEKDKEAEYAGQLAELRQRLDHAEADRQE 629
            A   EE  V Q++L +  +++ KQ+   +   ++   AE   +L  LR   +  E  RQ 
Sbjct: 1706 A---EEQAVRQRELAE--QELEKQRQLAEGTAQQRLAAEQ--ELIRLRAETEQGEQQRQL 1758

Query: 630  LQDEL-RQEREA------RQKLEMMIKELK--LQILKSSKTAKE 664
            L++EL R +REA      RQ+LE  + +++  +++L +SK   E
Sbjct: 1759 LEEELARLQREAAAATQKRQELEAELAKVRAEMEVLLASKARAE 1802



 Score = 44.3 bits (103), Expect = 4e-04
 Identities = 65/296 (21%), Positives = 123/296 (41%), Gaps = 43/296 (14%)

Query: 401  QSKELTKTEASKSISRQSEKAHSSGK---------LQKTVSYPDVSLEE------QEKMD 445
            + + L + EA+    RQ  +AH+  K         LQ+ +    V  EE      Q+K  
Sbjct: 1385 ERERLAEVEAALEKQRQLAEAHAQAKAQAEREAKELQQRMQEEVVRREEAAVDAQQQKRS 1444

Query: 446  LKTS-RELCSRLDASISNNSTSKRKSESATCNLVRDINKVGIGLVAAAS---------SP 495
            ++   ++L    +A I   +     +E +   +  +I  V + L A              
Sbjct: 1445 IQEELQQLRQSSEAEIQAKARQAEAAERSRLRIEEEIRVVRLQLEATERQRGGAEGELQA 1504

Query: 496  LLVKDVICEDDKGKIMEEVMRTYLKQQEKLNLILQKKQQLQMEVKMLSSSKSMKELTEEQ 555
            L  +    E  K +  EE  R   + Q+      + +++ Q EV++ S  K+  E   E+
Sbjct: 1505 LRARAEEAEAQKRQAQEEAERLRRQVQD------ESQRKRQAEVELASRVKAEAEAAREK 1558

Query: 556  QNLQKELES--LQNEHAQRMEEFYVEQKDLEKKLE-QIMKQKCTCDSNLE-KDKEAEYAG 611
            Q   + LE   LQ E A+R     + Q ++E+  + Q+  +     +  E + K A +A 
Sbjct: 1559 QRALQALEELRLQAEEAERR----LRQAEVERARQVQVALETAQRSAEAELQSKRASFAE 1614

Query: 612  QLAELRQRLDHAEAD----RQELQDELRQEREARQKLEMMIKELKLQILKSSKTAK 663
            + A+L + L          R+E +   +Q+ EA +  E   +EL+   LK+++  +
Sbjct: 1615 KTAQLERSLQEEHVAVAQLREEAERRAQQQAEAERAREEAERELERWQLKANEALR 1670



 Score = 38.1 bits (87), Expect = 0.026
 Identities = 28/140 (20%), Positives = 69/140 (49%), Gaps = 6/140 (4%)

Query: 531  KKQQLQMEVKMLSSSKSMKELTEEQQNLQKELESLQNEHAQRMEEFYVEQKDLEKKLEQI 590
            K+ Q +M+ +++   ++  +  ++++++Q+EL+ L+      ++    + +  E+   +I
Sbjct: 1418 KELQQRMQEEVVRREEAAVDAQQQKRSIQEELQQLRQSSEAEIQAKARQAEAAERSRLRI 1477

Query: 591  MKQKCTCDSNLEKDKEAEYA--GQLAELRQRLDHAEADRQELQDEL----RQEREARQKL 644
             ++       LE  +       G+L  LR R + AEA +++ Q+E     RQ ++  Q+ 
Sbjct: 1478 EEEIRVVRLQLEATERQRGGAEGELQALRARAEEAEAQKRQAQEEAERLRRQVQDESQRK 1537

Query: 645  EMMIKELKLQILKSSKTAKE 664
                 EL  ++   ++ A+E
Sbjct: 1538 RQAEVELASRVKAEAEAARE 1557



 Score = 37.7 bits (86), Expect = 0.034
 Identities = 41/161 (25%), Positives = 79/161 (49%), Gaps = 13/161 (8%)

Query: 496  LLVKDVICEDDKGKIMEEVMRTYLKQQEKLNLILQKKQQLQMEVKMLSSSKSMKELTEEQ 555
            LL ++   E +K K+ E++ +  + + ++L    Q++QQ QME +      SM+E    Q
Sbjct: 2529 LLQRERFIEQEKAKL-EQLFQDEVAKAQQLREEQQRQQQ-QMEQERQRLVASMEEARRRQ 2586

Query: 556  -------QNLQKELESLQNEHAQRMEEFYVEQKDLEKKLEQIMKQKCTCDSNLEKDKEAE 608
                   +  Q+EL+ L+ +  Q+ E    E + L ++L+ + +Q     ++ E+   ++
Sbjct: 2587 HEAEEGVRRKQEELQQLEQQRRQQEELLAEENQRLREQLQLLEEQHRAALAHSEEVTASQ 2646

Query: 609  YAG--QLAELRQRLD--HAEADRQELQDELRQEREARQKLE 645
             A    L   R  LD   AEA+ +   D LR++  A++  E
Sbjct: 2647 VAATKTLPNGRDALDGPAAEAEPEHSFDGLRRKVSAQRLQE 2687



 Score = 35.8 bits (81), Expect = 0.13
 Identities = 54/281 (19%), Positives = 116/281 (41%), Gaps = 36/281 (12%)

Query: 396  TSAVSQSKELTKTEASKSISRQSEKAHSSGKLQKTVSYPDVSLEEQEKMDLKTSRELCSR 455
            T    Q ++L + E ++    Q E A ++ K Q+  +       E  K+  +    L S+
Sbjct: 1749 TEQGEQQRQLLEEELARL---QREAAAATQKRQELEA-------ELAKVRAEMEVLLASK 1798

Query: 456  LDASISNNSTSKRKSE--SATCNLVRDINKVGIGLVAAASSPLLVKDVICEDDKGKIMEE 513
              A   + STS++  +   A     R++ +    L A A      +  + E+D  +   E
Sbjct: 1799 ARAEEESRSTSEKSKQRLEAEAGRFRELAEEAARLRALAEEAKRQRQ-LAEEDAARQRAE 1857

Query: 514  VMRTYLKQQEKLNLILQKKQQLQMEVKMLSS-SKSMKELTEEQQNLQKELESLQNEHAQR 572
              R   ++   +    + K + ++ +K   + ++ ++ L E++   ++ LE    +H   
Sbjct: 1858 AERVLAEKLAAIGEATRLKTEAEIALKEKEAENERLRRLAEDEAFQRRRLEEQAAQH--- 1914

Query: 573  MEEFYVEQKDLEKKLEQIMKQKCTCDSNLEKDK---------EAEYAGQLAELRQRLDHA 623
                   + D+E++L Q+ K     DS LE+ K           +   ++  L+   + A
Sbjct: 1915 -------KADIEERLAQLRK---ASDSELERQKGLVEDTLRQRRQVEEEILALKASFEKA 1964

Query: 624  EADRQELQDELRQEREARQKLEMMIKELKLQILKSSKTAKE 664
             A + EL+ EL + R   +      ++ +L+  +  + A E
Sbjct: 1965 AAGKAELELELGRIRSNAEDTLRSKEQAELEAARQRQLAAE 2005



 Score = 35.0 bits (79), Expect = 0.22
 Identities = 81/419 (19%), Positives = 162/419 (38%), Gaps = 86/419 (20%)

Query: 313  QKYLGTPEE--KKLKIILEEMKE-KFSMRSGKRNQSKTDAPSGMELQSWYPVIKQEGDHV 369
            QK L   EE  ++ K  LEE++  K  +   +R + + +  S  +LQ      ++     
Sbjct: 2018 QKSLAAEEEAARQRKAALEEVERLKAKVEEARRLRERAEQESARQLQLAQEAAQKRLQAE 2077

Query: 370  SQTHSFLHPSYYLYMCDKVVAPNVSLTSAVSQSKELT-----KTEASKSISRQSEKAHSS 424
             + H+F            V      L   + Q + +      + EA++  + ++E+A   
Sbjct: 2078 EKAHAFA-----------VQQKEQELQQTLQQEQSVLDQLRGEAEAARRAAEEAEEARVQ 2126

Query: 425  GKLQKTVSYPDVSLEEQEKMDLKTSRELCSRLDASISNNSTSKRKSESATCNLVRDINKV 484
             + +   S   V  EE E++      +  +R  A  +     K   + A      +  + 
Sbjct: 2127 AEREAAQSRRQV--EEAERLKQSAEEQAQARAQAQAAAEKLRKEAEQEAARRAQAE--QA 2182

Query: 485  GIGLVAAASSPLLVKDVICED---DKGKIMEEVMRTYLKQQE---KLNLILQKKQQL--- 535
             +    AA + +       E     K ++ +E+    L+ +E   + NL+ ++ Q+L   
Sbjct: 2183 ALRQKQAADAEMEKHKKFAEQTLRQKAQVEQELTTLRLQLEETDHQKNLLDEELQRLKAE 2242

Query: 536  ---------QMEVKMLSSSKSMKELTE-------------------EQQNLQKELESLQN 567
                     Q+E ++ S    M+EL++                    Q+ LQ+E E ++ 
Sbjct: 2243 ATEAARQRSQVEEELFSVRVQMEELSKLKARIEAENRALILRDKDNTQRFLQEEAEKMKQ 2302

Query: 568  --EHAQRMEEFYVEQKDLEKKLEQIMKQKCTCDSNLEKDK------------EAEYAGQL 613
              E A R+     E   L +  E+ + Q+      + K+K            EAE   Q 
Sbjct: 2303 VAEEAARLSVAAQEAARLRQLAEEDLAQQRALAEKMLKEKMQAVQEATRLKAEAELLQQQ 2362

Query: 614  AELRQ-RLDHAEADRQELQDELRQ---------EREARQKLEMM--IKELKLQILKSSK 660
             EL Q +    + D++++  +L +         E E +++LEM    + LKL++ + S+
Sbjct: 2363 KELAQEQARRLQEDKEQMAQQLAEETQGFQRTLEAERQRQLEMSAEAERLKLRVAEMSR 2421



 Score = 32.0 bits (71), Expect = 1.9
 Identities = 34/158 (21%), Positives = 73/158 (46%), Gaps = 24/158 (15%)

Query: 512  EEVMRTY---LKQQEKLNLILQKKQQLQMEVKMLSSSKSMKE-----LTEEQQNLQKELE 563
            EEV+R +   LK+ + +   L + +  +  +K L +    ++     L +E +  Q+  E
Sbjct: 1129 EEVLRAHEEQLKEAQAVPATLPELEATKASLKKLRAQAEAQQPTFDALRDELRGAQEVGE 1188

Query: 564  SLQNEHAQR---MEEFYVEQKDLEKKLEQIMKQKCTCDSNLEK-DKEAEYAGQ------- 612
             LQ  H +R   +E +      L ++ + ++ Q       LE+  ++  Y  +       
Sbjct: 1189 RLQQRHGERDVEVERWRERVAQLLERWQAVLAQTDVRQRELEQLGRQLRYYRESADPLGA 1248

Query: 613  -LAELRQRLDHAEA----DRQELQDELRQEREARQKLE 645
             L + R+R +  +A    D Q ++++LRQE+   +++E
Sbjct: 1249 WLQDARRRQEQIQAMPLADSQAVREQLRQEQALLEEIE 1286


>gi|21735548 centrosomal protein 2 [Homo sapiens]
          Length = 2442

 Score = 56.2 bits (134), Expect = 9e-08
 Identities = 55/266 (20%), Positives = 121/266 (45%), Gaps = 33/266 (12%)

Query: 393  VSLTSAVSQS-KELTKTEASKSISRQSEKAHSSGKLQKTVSYPDVSLEEQEKMDLKTSRE 451
            VSL   + Q+ KEL          RQ  K     K Q+T       L+E ++   + +R+
Sbjct: 928  VSLLETLLQTQKELADASQQLERLRQDMKVQKL-KEQETTGILQTQLQEAQRELKEAARQ 986

Query: 452  LCSRLDASISNNSTSKRKSESATCNLVRDINKVGIGLVAAASSPLLVKDVICEDDKGKIM 511
                L A++   S+S  + +      V D+                   ++ +DD  +++
Sbjct: 987  HRDDL-AALQEESSSLLQDKMDLQKQVEDLKS----------------QLVAQDDSQRLV 1029

Query: 512  EEVMRTYLKQQEKLNLILQK--KQQLQMEVKMLSSSKSMKELTEEQQNLQKELESLQNEH 569
            E+ ++  L++ ++ N I ++  +++  + + ++   + +  L E     Q+EL +L+   
Sbjct: 1030 EQEVQEKLRETQEYNRIQKELEREKASLTLSLMEKEQRLLVLQEADSIRQQELSALR--- 1086

Query: 570  AQRMEEFYVEQKDLEKKLEQIMKQKCTCDSNLEKDKEAEYAGQLAELRQRLDHAEADRQE 629
             Q M+E   EQK+L  ++E + ++         K+KEA++  Q A+L + L+ +    Q+
Sbjct: 1087 -QDMQEAQGEQKELSAQMELLRQEV--------KEKEADFLAQEAQLLEELEASHITEQQ 1137

Query: 630  LQDELRQEREARQKLEMMIKELKLQI 655
            L+  L  +     +L++ ++  + Q+
Sbjct: 1138 LRASLWAQEAKAAQLQLRLRSTESQL 1163



 Score = 50.1 bits (118), Expect = 7e-06
 Identities = 58/282 (20%), Positives = 127/282 (45%), Gaps = 34/282 (12%)

Query: 404  ELTKTEASKSISRQSEKAHSSGKLQKTVSYPDVSLEEQEKMDLKTS-RELCSRLDASISN 462
            E  K    K +++  EK        +      +   E+EKM+L+   +E  + ++A  + 
Sbjct: 845  EQQKAAHEKEVNQLREKWEKERSWHQQELAKALESLEREKMELEMRLKEQQTEMEAIQAQ 904

Query: 463  NSTSKRKSESATCNLVRDINKVGIGLVAAASSPLLVKDVICEDDKGKIMEEVMRTY-LKQ 521
                + ++ESA C +  +  K  + L+         K++     + + + + M+   LK+
Sbjct: 905  REEERTQAESALCQMQLETEKERVSLLETLLQTQ--KELADASQQLERLRQDMKVQKLKE 962

Query: 522  QEKLNLILQKKQQLQMEVK---------MLSSSKSMKELTEEQQNLQKELESLQNE---- 568
            QE   ++  + Q+ Q E+K         + +  +    L +++ +LQK++E L+++    
Sbjct: 963  QETTGILQTQLQEAQRELKEAARQHRDDLAALQEESSSLLQDKMDLQKQVEDLKSQLVAQ 1022

Query: 569  -HAQRMEEFYVE------------QKDLEKKLEQIMKQKCTCDSNLEKDKEAEYAGQ--L 613
              +QR+ E  V+            QK+LE++   +       +  L   +EA+   Q  L
Sbjct: 1023 DDSQRLVEQEVQEKLRETQEYNRIQKELEREKASLTLSLMEKEQRLLVLQEADSIRQQEL 1082

Query: 614  AELRQRLDHAEADRQEL--QDELRQEREARQKLEMMIKELKL 653
            + LRQ +  A+ +++EL  Q EL ++    ++ + + +E +L
Sbjct: 1083 SALRQDMQEAQGEQKELSAQMELLRQEVKEKEADFLAQEAQL 1124



 Score = 42.7 bits (99), Expect = 0.001
 Identities = 35/144 (24%), Positives = 71/144 (49%), Gaps = 12/144 (8%)

Query: 521  QQEKLNLILQKKQQLQMEVKMLSSSKSMKELTEEQQNLQKELESLQNEHAQRMEEFYVEQ 580
            ++EK+ L ++ K+Q Q E++ + + +  +    E    Q +LE+ + E    +E     Q
Sbjct: 881  EREKMELEMRLKEQ-QTEMEAIQAQREEERTQAESALCQMQLET-EKERVSLLETLLQTQ 938

Query: 581  KDLEKKLEQIMKQKCTCDSNLEKDKEAEYAG----QLAELRQRLDHAEADRQE----LQD 632
            K+L    +Q+  ++   D  ++K KE E  G    QL E ++ L  A    ++    LQ+
Sbjct: 939  KELADASQQL--ERLRQDMKVQKLKEQETTGILQTQLQEAQRELKEAARQHRDDLAALQE 996

Query: 633  ELRQEREARQKLEMMIKELKLQIL 656
            E     + +  L+  +++LK Q++
Sbjct: 997  ESSSLLQDKMDLQKQVEDLKSQLV 1020



 Score = 41.2 bits (95), Expect = 0.003
 Identities = 42/145 (28%), Positives = 68/145 (46%), Gaps = 20/145 (13%)

Query: 521 QQEKLNLILQKKQQLQMEVKMLSSSKSMKELTEEQQNLQKELESLQNEHAQRMEEFYVEQ 580
           +QE    + Q+K   + EV  L   K  KE +  QQ L K LESL+ E           +
Sbjct: 837 EQEGKTALEQQKAAHEKEVNQLRE-KWEKERSWHQQELAKALESLERE-----------K 884

Query: 581 KDLEKKLEQIMKQKCTCDSNLEKDKEAEYAGQLAELRQRLDHAEADRQELQDELRQER-- 638
            +LE +L    K++ T    ++  +E E     + L Q     E +R  L + L Q +  
Sbjct: 885 MELEMRL----KEQQTEMEAIQAQREEERTQAESALCQMQLETEKERVSLLETLLQTQKE 940

Query: 639 --EARQKLEMMIKELKLQILKSSKT 661
             +A Q+LE + +++K+Q LK  +T
Sbjct: 941 LADASQQLERLRQDMKVQKLKEQET 965



 Score = 40.0 bits (92), Expect = 0.007
 Identities = 60/268 (22%), Positives = 113/268 (42%), Gaps = 49/268 (18%)

Query: 403  KELTKTEASKS-------------ISRQSEKAHSSGKLQKTVSYPDVSLEEQEKMDL-KT 448
            + LT TEA KS                Q EK+   GK             E E M+L +T
Sbjct: 1271 ERLTDTEAEKSQVHTELQDLQRQLSQNQEEKSKWEGKQNSL---------ESELMELHET 1321

Query: 449  SRELCSRLDASISNNSTSKRKSE---SATCNLVRDINKVGIGLVAA----ASSPLLVKDV 501
               L SRL  +      ++ + E   +A  NL   +  +   +V A    +++ +L +D+
Sbjct: 1322 MASLQSRLRRAELQRMEAQGERELLQAAKENLTAQVEHLQAAVVEARAQASAAGILEEDL 1381

Query: 502  ICEDDKGKIMEEVMRTYLKQ----QEKLNLILQKKQQLQMEVKMLSSSKSMKELTEEQQN 557
                   K+  E + +  ++    QE+  L + + + LQ  + +L+ + + +E  EE + 
Sbjct: 1382 RTARSALKLKNEEVESERERAQALQEQGELKVAQGKALQENLALLTQTLAERE--EEVET 1439

Query: 558  LQKELESLQNEHAQRMEEFYVEQKDLEKKLEQIMKQKCTCDSNLEKDKEAEYAGQLAELR 617
            L+ +++ L+ +   +     +   DL+K+             N E D + E   +L + R
Sbjct: 1440 LRGQIQELEKQREMQKAALELLSLDLKKR-------------NQEVDLQQEQIQELEKCR 1486

Query: 618  QRLDHAEADRQELQDELRQEREARQKLE 645
              L+H     QE + +L  +RE  ++LE
Sbjct: 1487 SVLEHLPMAVQEREQKLTVQREQIRELE 1514



 Score = 37.7 bits (86), Expect = 0.034
 Identities = 28/114 (24%), Positives = 58/114 (50%), Gaps = 13/114 (11%)

Query: 545 SKSMKELTEEQQNLQKELESLQNEHAQRMEEFYVEQKDLEKKLEQIMKQKCTCDSNLEKD 604
           ++ + +L EE Q++   +E+ +    Q      V+  + EK+ E + ++    ++ L+K 
Sbjct: 616 NQQLLQLEEENQSVCSRMEAAE----QARNALQVDLAEAEKRREALWEKNTHLEAQLQKA 671

Query: 605 KEAEYAGQLAELRQRLDHAEADRQELQDEL----RQEREARQKLEMMIKELKLQ 654
           +EA      AEL+  L   + +++E+Q +L     Q+  A  +LE + +E K Q
Sbjct: 672 EEAG-----AELQADLRDIQEEKEEIQKKLSESRHQQEAATTQLEQLHQEAKRQ 720



 Score = 37.0 bits (84), Expect = 0.058
 Identities = 39/183 (21%), Positives = 84/183 (45%), Gaps = 34/183 (18%)

Query: 506 DKGKIMEEVMRTYLKQQEKLNLI---------------LQKKQQLQMEVKMLSSSKSMKE 550
           ++ ++ E +M    KQ E L+ +               L +++Q ++   +  + +S+ E
Sbjct: 520 ERERLQEMLMGLEAKQSESLSELITLREALESSHLEGELLRQEQTEVTAALARAEQSIAE 579

Query: 551 LTEEQQNLQKELESLQNEHAQRM---EEFYVEQKDLEKKLEQIMKQKCTCDSNLEKDKEA 607
           L+  +  L+ E+  L+    +     E   +++  L ++L Q+ ++  +  S +E  ++A
Sbjct: 580 LSSSENTLKTEVADLRAAAVKLSALNEALALDKVGLNQQLLQLEEENQSVCSRMEAAEQA 639

Query: 608 EYAGQ--LAELRQRLD-------HAEADRQ-------ELQDELRQEREARQKLEMMIKEL 651
             A Q  LAE  +R +       H EA  Q       ELQ +LR  +E +++++  + E 
Sbjct: 640 RNALQVDLAEAEKRREALWEKNTHLEAQLQKAEEAGAELQADLRDIQEEKEEIQKKLSES 699

Query: 652 KLQ 654
           + Q
Sbjct: 700 RHQ 702



 Score = 36.2 bits (82), Expect = 0.100
 Identities = 41/140 (29%), Positives = 63/140 (45%), Gaps = 8/140 (5%)

Query: 519  LKQQEKLNLILQKKQQLQMEVKMLSSSKSMKELTEEQQNL---QKELESLQNE--HAQRM 573
            L Q+E+  ++LQ++ Q   E   L       +L E Q+ L    +ELE+LQ E   AQ  
Sbjct: 1773 LSQREQEIVVLQQQLQEAREQGELKEQSLQSQLDEAQRALAQRDQELEALQQEQQQAQGQ 1832

Query: 574  EEFYVEQKD-LEKKLEQIMKQKCTCDSNLEKDKE--AEYAGQLAELRQRLDHAEADRQEL 630
            EE   E+ D L+  LEQ           L+  KE       +LA   +R+   E    +L
Sbjct: 1833 EERVKEKADALQGALEQAHMTLKERHGELQDHKEQARRLEEELAVEGRRVQALEEVLGDL 1892

Query: 631  QDELRQEREARQKLEMMIKE 650
            + E R++ +A   L+    E
Sbjct: 1893 RAESREQEKALLALQQQCAE 1912



 Score = 34.3 bits (77), Expect = 0.38
 Identities = 26/121 (21%), Positives = 60/121 (49%), Gaps = 19/121 (15%)

Query: 546 KSMKELTEEQQNLQKELESLQNEHAQRMEEFYVEQKDLEKKLEQIMKQKCTCDSNLEKDK 605
           +++++L ++    Q+ +  LQ +H Q  E    E K L ++L+++  ++ T         
Sbjct: 400 QAVQDLRQQLAGCQEAVNLLQQQHDQWEE----EGKALRQRLQKLTGERDT--------- 446

Query: 606 EAEYAGQLAELRQRLDHAEADRQELQ---DELRQEREARQKLEMMIKELKLQILKSSKTA 662
               AGQ  +L+  +D    +R+ LQ   +ELRQ+ E  ++    ++ + +++     +A
Sbjct: 447 ---LAGQTVDLQGEVDSLSKERELLQKAREELRQQLEVLEQEAWRLRRVNVELQLQGDSA 503

Query: 663 K 663
           +
Sbjct: 504 Q 504



 Score = 34.3 bits (77), Expect = 0.38
 Identities = 42/221 (19%), Positives = 93/221 (42%), Gaps = 23/221 (10%)

Query: 435  DVSLEEQEKMDLKTSRELCSRLDASISNNSTSKRKSESATCNLVRDINKVGIGLVAAASS 494
            +V L++++  +L+  R +   L  ++                L +D  +    ++     
Sbjct: 1471 EVDLQQEQIQELEKCRSVLEHLPMAVQEREQKLTVQREQIRELEKD-RETQRNVLEHQLL 1529

Query: 495  PLLVKDVICEDDKGKIMEEVMRTYLKQQEKLNLILQKKQ-QLQMEVKMLSSSKSMKE--- 550
             L  KD + E  +G++ +  ++  L   E L L L++   +++ + K++   +  +E   
Sbjct: 1530 ELEKKDQMIESQRGQVQD--LKKQLVTLECLALELEENHHKMECQQKLIKELEGQRETQR 1587

Query: 551  ---------LTEEQQNLQKE------LESLQNEHAQRMEEFYVEQKDLEKKLEQIMKQKC 595
                     L E  Q LQ +      LES     A+ ++E   E K   +++E++ +QK 
Sbjct: 1588 VALTHLTLDLEERSQELQAQSSQIHDLESHSTVLARELQERDQEVKSQREQIEELQRQKE 1647

Query: 596  TCDSNLEKDKEAEYAGQLAELRQRLDHAEADRQELQDELRQ 636
                +LE+ ++ E   Q   ++   D      + L+++L Q
Sbjct: 1648 HLTQDLER-RDQELMLQKERIQVLEDQRTRQTKILEEDLEQ 1687



 Score = 32.7 bits (73), Expect = 1.1
 Identities = 52/241 (21%), Positives = 106/241 (43%), Gaps = 23/241 (9%)

Query: 406  TKTEASKSISRQSEKAHSSGK-LQKTVSYPDVSLEEQEKMDLKTSRELCSRLDASISNNS 464
            ++ E ++++  Q E   + GK LQ+ ++    +L E+E+ +++T R     L+       
Sbjct: 1397 SERERAQALQEQGELKVAQGKALQENLALLTQTLAEREE-EVETLRGQIQELE------- 1448

Query: 465  TSKRKSESATCNLVRDINKVGIGLVAAASSPLLVKDVICEDDKGKIMEEVMRTYLKQQEK 524
              +R+ + A   L+       + L        L ++ I E +K + + E +   ++++E+
Sbjct: 1449 -KQREMQKAALELL------SLDLKKRNQEVDLQQEQIQELEKCRSVLEHLPMAVQEREQ 1501

Query: 525  LNLILQKKQQLQMEVKMLSSSKSMKELTEEQQNLQKELESLQNEHAQRMEEFYVEQKDLE 584
              L +Q++Q  ++E    +    ++    E +   + +ES Q    Q +++  V  + L 
Sbjct: 1502 -KLTVQREQIRELEKDRETQRNVLEHQLLELEKKDQMIES-QRGQVQDLKKQLVTLECLA 1559

Query: 585  KKLEQIMKQKCTCDSNLEKDKEAEYAGQLAELRQRLDHAEADRQELQDELRQEREARQKL 644
             +LE+    K  C   L K+ E    GQ    R  L H   D +E   EL+ +      L
Sbjct: 1560 LELEE-NHHKMECQQKLIKELE----GQRETQRVALTHLTLDLEERSQELQAQSSQIHDL 1614

Query: 645  E 645
            E
Sbjct: 1615 E 1615


>gi|63252902 tropomyosin 1 alpha chain isoform 2 [Homo sapiens]
          Length = 284

 Score = 55.1 bits (131), Expect = 2e-07
 Identities = 54/228 (23%), Positives = 111/228 (48%), Gaps = 13/228 (5%)

Query: 440 EQEKMDLKTSRELCSRLDASISNNSTSKRKSESATCNLVRDINKVGIGLVAAASSPLLVK 499
           EQ + D K + +   +L+  I+      R SE     ++ +++K    L+AA  +    +
Sbjct: 23  EQAEADKKAAEDRSKQLEEDIAAKEKLLRVSEDERDRVLEELHKAEDSLLAAEEAAAKAE 82

Query: 500 -DVICEDDKGKIMEEVMRTYLKQQEKLNLILQKKQQLQMEVKMLSSSKSMKELTEEQQNL 558
            DV   + + +++EE +    + QE+L   LQK ++ +       S + MK +   +   
Sbjct: 83  ADVASLNRRIQLVEEELD---RAQERLATALQKLEEAEKAAD--ESERGMKVI---ESRA 134

Query: 559 QKELESLQNEHAQRMEEFYVEQKDLEKKLEQIMKQKCTCDSNLEKDKE-AEYA-GQLAEL 616
           QK+ E ++ +  Q  E  ++ + D ++K E++ ++    +S+LE+ +E AE + G+ AEL
Sbjct: 135 QKDEEKMEIQEIQLKEAKHIAE-DADRKYEEVARKLVIIESDLERAEERAELSEGKCAEL 193

Query: 617 RQRLDHAEADRQELQDELRQEREARQKLEMMIKELKLQILKSSKTAKE 664
            + L     + + L+ +  +  +   + E  IK L    LK ++T  E
Sbjct: 194 EEELKTVTNNLKSLEAQAEKYSQKEDRYEEEIKVLS-DKLKEAETRAE 240


>gi|41872583 Rho-associated, coiled-coil containing protein kinase 2
           [Homo sapiens]
          Length = 1388

 Score = 54.7 bits (130), Expect = 3e-07
 Identities = 51/224 (22%), Positives = 107/224 (47%), Gaps = 16/224 (7%)

Query: 447 KTSRELCSRLDASISNNSTSKRKSE-SATCNLVRDINKVGIGLVAAASSPLLVKDVICED 505
           K++ E+       +   S  + ++E  AT   + D NK+   +  A S  +       ++
Sbjct: 683 KSNMEIDMTYQLKVIQQSLEQEEAEHKATKARLADKNKIYESIEEAKSEAM-------KE 735

Query: 506 DKGKIMEEVMRTYLKQQEKLNLILQKKQQLQMEVKMLSSSKSMKELTEEQQNLQKELESL 565
            + K++EE  RT  ++ E L L  +K+  L ++  +  S + + EL +++  L +++ +L
Sbjct: 736 MEKKLLEE--RTLKQKVENLLLEAEKRCSL-LDCDLKQSQQKINELLKQKDVLNEDVRNL 792

Query: 566 QNEHAQRMEEFYVEQKDLEKKLEQIMKQKCT-----CDSNLEKDKEAEYAGQLAELRQRL 620
             +  Q  ++  + Q DL+ + +Q+   K +      ++N   + +     Q AELR+  
Sbjct: 793 TLKIEQETQKRCLTQNDLKMQTQQVNTLKMSEKQLKQENNHLMEMKMNLEKQNAELRKER 852

Query: 621 DHAEADRQELQDELRQEREARQKLEMMIKELKLQILKSSKTAKE 664
             A+   +ELQD+L  E+      +  ++ELK +  + +K  KE
Sbjct: 853 QDADGQMKELQDQLEAEQYFSTLYKTQVRELKEECEEKTKLGKE 896



 Score = 42.7 bits (99), Expect = 0.001
 Identities = 63/293 (21%), Positives = 125/293 (42%), Gaps = 45/293 (15%)

Query: 401 QSKELTKTEASKSISRQSEKAHSSGKLQKTVSYPDVSLEEQEKMDLKTSRELCSRLDASI 460
           Q K + ++   +    ++ KA  + K +   S  +   E  ++M+ K   E    L   +
Sbjct: 693 QLKVIQQSLEQEEAEHKATKARLADKNKIYESIEEAKSEAMKEMEKKLLEE--RTLKQKV 750

Query: 461 SNNSTSKRKSESAT-CNLVRDINKVGIGLVAAASSPLLVKDVICEDDKG---KIMEEVMR 516
            N      K  S   C+L +   K+        +  L  KDV+ ED +    KI +E  +
Sbjct: 751 ENLLLEAEKRCSLLDCDLKQSQQKI--------NELLKQKDVLNEDVRNLTLKIEQETQK 802

Query: 517 TYLKQQE------KLNLILQKKQQLQ------MEVKMLSSSKSMKELTEEQQNLQKELES 564
             L Q +      ++N +   ++QL+      ME+KM +  K   EL +E+Q+   +++ 
Sbjct: 803 RCLTQNDLKMQTQQVNTLKMSEKQLKQENNHLMEMKM-NLEKQNAELRKERQDADGQMKE 861

Query: 565 LQN--EHAQRMEEFYVEQ---------------KDLEKKLEQIMKQKCTCDSNLEKDKEA 607
           LQ+  E  Q     Y  Q               K+L++K +++  ++ +  + LE     
Sbjct: 862 LQDQLEAEQYFSTLYKTQVRELKEECEEKTKLGKELQQKKQELQDERDSLAAQLEITLTK 921

Query: 608 EYAGQLAELRQRLDHAEADRQELQDELR-QEREARQKLEMMIKELKLQILKSS 659
             + QLA       +++ +++++  EL  +E  AR K E+  K+  +  L+ +
Sbjct: 922 ADSEQLARSIAEEQYSDLEKEKIMKELEIKEMMARHKQELTEKDATIASLEET 974



 Score = 35.0 bits (79), Expect = 0.22
 Identities = 42/180 (23%), Positives = 81/180 (45%), Gaps = 41/180 (22%)

Query: 507 KGKIMEEVMRTYLKQQEKLNLILQKKQQLQMEVKMLSS--SKSMKELTEE---------- 554
           K +  +E+ +     +E L+  +Q K++L+ + K +++   K+ KEL EE          
Sbjct: 438 KNEESQEIQKKLYTLEEHLSNEMQAKEELEQKCKSVNTRLEKTAKELEEEITLRKSVESA 497

Query: 555 QQNLQKELESLQNEHA--QRMEEFYVEQK---------------DLEK----------KL 587
            + L++E   LQ+++A  QR  +   ++K               DL+K          K+
Sbjct: 498 LRQLEREKALLQHKNAEYQRKADHEADKKRNLENDVNSLKDQLEDLKKRNQNSQISTEKV 557

Query: 588 EQIMKQKCTCDSNL--EKDKEAEYAGQLAELRQRLDHAEADRQELQDELRQEREARQKLE 645
            Q+ +Q    ++ L  E D  A      AE  +++   E++ ++LQD+      A+ KLE
Sbjct: 558 NQLQRQLDETNALLRTESDTAARLRKTQAESSKQIQQLESNNRDLQDKNCLLETAKLKLE 617



 Score = 31.2 bits (69), Expect = 3.2
 Identities = 41/188 (21%), Positives = 91/188 (48%), Gaps = 33/188 (17%)

Query: 506  DKGKIMEEVMRTYLKQQEKLNL---------ILQKKQQLQMEVKMLSSSKSMKELTEEQQ 556
            +K KIM+E+    +  + K  L         + +  + L  +V  L++ K  +EL  + +
Sbjct: 940  EKEKIMKELEIKEMMARHKQELTEKDATIASLEETNRTLTSDVANLANEK--EELNNKLK 997

Query: 557  NLQKELESLQNEHAQ------RMEEFYVEQKDLE----KKLEQIMKQKCTC----DSNLE 602
            ++Q++L  L++E         + E+  + ++ L+     KL +IM +K       D+++ 
Sbjct: 998  DVQEQLSRLKDEEISAAAIKAQFEKQLLTERTLKTQAVNKLAEIMNRKEPVKRGNDTDVR 1057

Query: 603  -KDKE-----AEYAGQLAELRQRLDHAEADRQELQDELRQEREARQKLEMMI--KELKLQ 654
             K+KE      E   +  +L Q++   + +  E+Q ++ +E + R +L+M +  K+  ++
Sbjct: 1058 RKEKENRKLHMELKSEREKLTQQMIKYQKELNEMQAQIAEESQIRIELQMTLDSKDSDIE 1117

Query: 655  ILKSSKTA 662
             L+S   A
Sbjct: 1118 QLRSQLQA 1125


>gi|148746195 trichohyalin [Homo sapiens]
          Length = 1943

 Score = 54.3 bits (129), Expect = 4e-07
 Identities = 37/160 (23%), Positives = 85/160 (53%), Gaps = 12/160 (7%)

Query: 499  KDVICEDDKGKIMEEVMRTYLKQQEKLNLILQKKQQLQMEVKMLSSSKSMKELTEEQQNL 558
            + ++ E+ + +  +E  R Y K+ E    + Q+++QL  E +     +  +    E++ L
Sbjct: 1001 EQLLREEREKRRRQEWERQYRKKDE----LQQEEEQLLREEREKRRLQERERQYREEEEL 1056

Query: 559  QKELESLQNEHA-----QRMEEFYVEQKDLEKKLEQIMKQKCTCDSNLEKDKEAEYAGQL 613
            Q+E E L  E       Q +E  Y ++++L+++ EQ+++++       E++++     +L
Sbjct: 1057 QQEEEQLLGEERETRRRQELERQYRKEEELQQEEEQLLREEPEKRRRQERERQCREEEEL 1116

Query: 614  AELRQRLDHAEAD---RQELQDELRQEREARQKLEMMIKE 650
             +  ++L   E +   RQEL+ + R+E E +Q+ E +++E
Sbjct: 1117 QQEEEQLLREEREKRRRQELERQYREEEEVQQEEEQLLRE 1156



 Score = 51.2 bits (121), Expect = 3e-06
 Identities = 32/127 (25%), Positives = 62/127 (48%), Gaps = 10/127 (7%)

Query: 530 QKKQQLQMEVKMLSSSKSMKELTEEQQNLQKELESLQNEHAQRMEEFYVEQKDL------ 583
           +K+QQ +     +   +  KE  + +  L+KE E LQ E  QR  E   E++ L      
Sbjct: 225 EKQQQRRERQDRVFQEEEEKEWRKRETVLRKEEEKLQEEEPQRQRELQEEEEQLRKLERQ 284

Query: 584 ----EKKLEQIMKQKCTCDSNLEKDKEAEYAGQLAELRQRLDHAEADRQELQDELRQERE 639
               E++ E+  +Q+   +  L + +E E   Q  E R++ +  E   +  + +LR+E+E
Sbjct: 285 ELRRERQEEEQQQQRLRREQQLRRKQEEERREQQEERREQQERREQQEERREQQLRREQE 344

Query: 640 ARQKLEM 646
            R++ ++
Sbjct: 345 ERREQQL 351



 Score = 47.8 bits (112), Expect = 3e-05
 Identities = 34/160 (21%), Positives = 85/160 (53%), Gaps = 12/160 (7%)

Query: 499  KDVICEDDKGKIMEEVMRTYLKQQEKLNLILQKKQQLQMEVKMLSSSKSMKELTEEQQNL 558
            + ++ E+ + + ++E  R Y +++E    + Q+++QL  E +     + ++    +++ L
Sbjct: 1031 EQLLREEREKRRLQERERQYREEEE----LQQEEEQLLGEERETRRRQELERQYRKEEEL 1086

Query: 559  QKELESLQNEHA-----QRMEEFYVEQKDLEKKLEQIMKQKCTCDSNLEKDKEAEYAGQL 613
            Q+E E L  E       Q  E    E+++L+++ EQ+++++       E +++     ++
Sbjct: 1087 QQEEEQLLREEPEKRRRQERERQCREEEELQQEEEQLLREEREKRRRQELERQYREEEEV 1146

Query: 614  AELRQRLDHAEAD---RQELQDELRQEREARQKLEMMIKE 650
             +  ++L   E +   RQEL+ + R+E E +Q+ E +++E
Sbjct: 1147 QQEEEQLLREEPEKRRRQELERQYREEEELQQEEEQLLRE 1186



 Score = 47.4 bits (111), Expect = 4e-05
 Identities = 37/160 (23%), Positives = 83/160 (51%), Gaps = 12/160 (7%)

Query: 499  KDVICEDDKGKIMEEVMRTYLKQQEKLNLILQKKQQLQMEVKMLSSSKSMKELTEEQQNL 558
            + ++ E+ + +  +E  R Y K ++    + QK++QL  E       +  ++   E++ L
Sbjct: 941  EQLLREEREKRRRQERERQYRKDKK----LQQKEEQLLGEEPEKRRRQEREKKYREEEEL 996

Query: 559  QKELESLQNEHA-----QRMEEFYVEQKDLEKKLEQIMKQKCTCDSNLEKDKEAEYAGQL 613
            Q+E E L  E       Q  E  Y ++ +L+++ EQ+++++       E++++     +L
Sbjct: 997  QQEEEQLLREEREKRRRQEWERQYRKKDELQQEEEQLLREEREKRRLQERERQYREEEEL 1056

Query: 614  AELRQRLDHAEAD---RQELQDELRQEREARQKLEMMIKE 650
             +  ++L   E +   RQEL+ + R+E E +Q+ E +++E
Sbjct: 1057 QQEEEQLLGEERETRRRQELERQYRKEEELQQEEEQLLRE 1096



 Score = 46.6 bits (109), Expect = 7e-05
 Identities = 39/161 (24%), Positives = 81/161 (50%), Gaps = 17/161 (10%)

Query: 499  KDVICEDDKGKIMEEVMRTYLKQQEKLNLILQKKQQLQMEVKMLSSSKSMKELTEEQQNL 558
            + ++ E+ + +  +E+ R Y K++E    + Q+++QL  E       +  +    E++ L
Sbjct: 1061 EQLLGEERETRRRQELERQYRKEEE----LQQEEEQLLREEPEKRRRQERERQCREEEEL 1116

Query: 559  QKELESLQNEHA-----QRMEEFYVEQKDLEKKLEQIMKQKCTCDSNLEKDKEAEYAGQL 613
            Q+E E L  E       Q +E  Y E+++++++ EQ+++++       EK +  E   Q 
Sbjct: 1117 QQEEEQLLREEREKRRRQELERQYREEEEVQQEEEQLLREEP------EKRRRQELERQY 1170

Query: 614  AELRQRLDHAEADRQELQDELRQEREA--RQKLEMMIKELK 652
             E  +     E   +E Q++ RQERE   R++ E+  ++ K
Sbjct: 1171 REEEELQQEEEQLLREEQEKRRQERERQYREEEELQRQKRK 1211



 Score = 45.8 bits (107), Expect = 1e-04
 Identities = 40/147 (27%), Positives = 76/147 (51%), Gaps = 16/147 (10%)

Query: 506  DKGKIMEEVMRTYLKQQEKLNLILQKKQQLQMEVKMLSSSKSMKELTEEQQNLQKELESL 565
            ++ ++++E     L++QE+     +++QQL+ +       +  K L EEQQ  ++ELE  
Sbjct: 1671 EEEQLLQEGEEQQLRRQERDRKFREEEQQLRRQ------ERERKFLQEEQQLRRQELERK 1724

Query: 566  QNEHAQRMEEFYVEQKDLEKKLEQIMKQKCTCDS-------NLEKDKEAEYAGQLAELR- 617
              E  Q  +E   EQ   +++  +I++++              E+D++     QL + R 
Sbjct: 1725 FREEEQLRQETEQEQLRRQERYRKILEEEQLRPEREEQQLRRQERDRKFREEEQLRQERE 1784

Query: 618  -QRLDHAEADRQELQDE-LRQEREARQ 642
             Q+L   E+DR+  ++E LRQERE +Q
Sbjct: 1785 EQQLRSQESDRKFREEEQLRQEREEQQ 1811



 Score = 44.7 bits (104), Expect = 3e-04
 Identities = 42/147 (28%), Positives = 72/147 (48%), Gaps = 12/147 (8%)

Query: 509  KIMEEVMRTYLKQQEKLNLILQKKQQLQMEVK--MLSSSKSMKELTEEQQNLQKELESLQ 566
            K +EE  R  L++QE+    L+++QQL+ + +   L   +  K   EEQQ  ++E +   
Sbjct: 1375 KFLEEEQR--LRRQERERKFLKEEQQLRCQEREQQLRQDRDRKFREEEQQLSRQERDRKF 1432

Query: 567  NEHAQRMEEFYVEQKDL--EKKLEQIMKQKCTCDSNLEKDKE------AEYAGQLAELRQ 618
             E  Q++     E+K L  E++L Q   +K   +  L +++E       E   +  E  Q
Sbjct: 1433 REEEQQVRRQERERKFLEEEQQLRQERHRKFREEEQLLQEREEQQLHRQERDRKFLEEEQ 1492

Query: 619  RLDHAEADRQELQDELRQEREARQKLE 645
            +L   E DR+  + ELR +   R+ LE
Sbjct: 1493 QLRRQERDRKFREQELRSQEPERKFLE 1519



 Score = 44.3 bits (103), Expect = 4e-04
 Identities = 34/138 (24%), Positives = 69/138 (50%), Gaps = 3/138 (2%)

Query: 520 KQQEKLNLILQKKQQLQMEVKMLSSSKSMKE--LTEEQQNLQKELESLQNEHAQRMEEFY 577
           +QQ +    L+++QQL+ E ++    +  +E  L  EQ+  + E +  Q    QR++   
Sbjct: 392 EQQLRREQQLRREQQLRREQQLRREQQLRREQQLRREQEEERHEQKHEQERREQRLKREQ 451

Query: 578 VEQKDLEKKLEQIMK-QKCTCDSNLEKDKEAEYAGQLAELRQRLDHAEADRQELQDELRQ 636
            E++D  K+ E+  + ++      L++D+E E   +  +L +     + +R+E Q    Q
Sbjct: 452 EERRDWLKREEETERHEQERRKQQLKRDQEEERRERWLKLEEEERREQQERREQQLRREQ 511

Query: 637 EREARQKLEMMIKELKLQ 654
           E    Q+L+   +E +LQ
Sbjct: 512 EERREQRLKRQEEEERLQ 529



 Score = 43.5 bits (101), Expect = 6e-04
 Identities = 30/134 (22%), Positives = 74/134 (55%), Gaps = 8/134 (5%)

Query: 520  KQQEKLNLILQKKQQLQMEVKMLSSSKSMKELTEEQQNLQKELESLQNEHAQRMEEFYVE 579
            +++E+L    ++K++ Q + +     + +++  EE+Q L++E E  + +  +R    Y +
Sbjct: 908  EEEEELQREEREKRRRQEQERQYREEEQLQQ--EEEQLLREEREKRRRQERERQ---YRK 962

Query: 580  QKDLEKKLEQIMKQKCTCDSNLEKDKEAEYAGQLAELRQRLDHAEAD---RQELQDELRQ 636
             K L++K EQ++ ++       E++K+     +L +  ++L   E +   RQE + + R+
Sbjct: 963  DKKLQQKEEQLLGEEPEKRRRQEREKKYREEEELQQEEEQLLREEREKRRRQEWERQYRK 1022

Query: 637  EREARQKLEMMIKE 650
            + E +Q+ E +++E
Sbjct: 1023 KDELQQEEEQLLRE 1036



 Score = 43.1 bits (100), Expect = 8e-04
 Identities = 33/146 (22%), Positives = 75/146 (51%), Gaps = 11/146 (7%)

Query: 504  EDDKGKIMEEVMRTYLKQQEKLNLILQKKQQLQMEVKMLSSSKSMKELTEEQQNLQKELE 563
            E+++    ++  R +L+++++L    + +Q+ Q   +     + +++  EEQQ     L 
Sbjct: 1519 EEEQQLHRQQRQRKFLQEEQQLRRQERGQQRRQDRDRKFREEEQLRQEREEQQ-----LS 1573

Query: 564  SLQNEHAQRMEEFYVEQKDLEKKL----EQIMKQKCTCDSNLEKDKEAEYAGQLAELR-- 617
              + +   R+EE  V +++ E+K     +Q+ +Q+       E+D++     QL + R  
Sbjct: 1574 RQERDRKFRLEEQKVRRQEQERKFMEDEQQLRRQEGQQQLRQERDRKFREDEQLLQEREE 1633

Query: 618  QRLDHAEADRQELQDELRQEREARQK 643
            Q+L   E DR+ L++E +  R+ R++
Sbjct: 1634 QQLHRQERDRKFLEEEPQLRRQEREQ 1659



 Score = 42.7 bits (99), Expect = 0.001
 Identities = 34/130 (26%), Positives = 65/130 (50%), Gaps = 13/130 (10%)

Query: 534  QLQMEVKMLSSSKSMKELTEEQQN-----LQKELESLQNE-----HAQRMEEFYVEQKDL 583
            QL+ E K    +   K   +EQ       LQ+E E LQ E       Q  E  Y E++ L
Sbjct: 877  QLEEERKRRRHTLYAKPALQEQLRKEQQLLQEEEEELQREEREKRRRQEQERQYREEEQL 936

Query: 584  EKKLEQIMKQKCTCDSNLEKDKEAEYAGQLAELRQRLDHAEAD---RQELQDELRQEREA 640
            +++ EQ+++++       E++++     +L +  ++L   E +   RQE + + R+E E 
Sbjct: 937  QQEEEQLLREEREKRRRQERERQYRKDKKLQQKEEQLLGEEPEKRRRQEREKKYREEEEL 996

Query: 641  RQKLEMMIKE 650
            +Q+ E +++E
Sbjct: 997  QQEEEQLLRE 1006



 Score = 42.0 bits (97), Expect = 0.002
 Identities = 36/141 (25%), Positives = 76/141 (53%), Gaps = 10/141 (7%)

Query: 520 KQQEKLNLILQKKQQLQMEV----KMLSSSKSMKELTEE--QQNLQKELESLQNEHAQRM 573
           +++E+L   L+ +QQL+ E     + L   +  K L +E  +Q L++E E  +++  +R 
Sbjct: 523 EEEERLQQRLRSEQQLRREQEERREQLLKREEEKRLEQERREQRLKREQEERRDQLLKRE 582

Query: 574 EEFYVE--QKDLEKKLEQIMKQKCTCDSNLEKDKEAEYAGQ--LAELRQRLDHAEADRQE 629
           EE   +  +++ E++LEQ +K++       E+ +E     +    E RQ+L  +E   + 
Sbjct: 583 EERRQQRLKREQEERLEQRLKREEVERLEQEERREQRLKREEPEEERRQQLLKSEEQEER 642

Query: 630 LQDELRQEREARQKLEMMIKE 650
            Q +LR+E++ R++  +  +E
Sbjct: 643 RQQQLRREQQERREQRLKREE 663



 Score = 41.6 bits (96), Expect = 0.002
 Identities = 25/151 (16%), Positives = 80/151 (52%), Gaps = 8/151 (5%)

Query: 504 EDDKGKIMEEVMRTYLKQQEKLNLILQKKQQLQMEVKMLSSSKSMKELTEEQQNLQKELE 563
           E+ + +  E V+R   K++EKL     ++++ Q + ++    + +++L  ++   +++ E
Sbjct: 242 EEKEWRKRETVLR---KEEEKL-----QEEEPQRQRELQEEEEQLRKLERQELRRERQEE 293

Query: 564 SLQNEHAQRMEEFYVEQKDLEKKLEQIMKQKCTCDSNLEKDKEAEYAGQLAELRQRLDHA 623
             Q +  +R ++   +Q++  ++ ++  +++       E+ +E +   +  E R++    
Sbjct: 294 EQQQQRLRREQQLRRKQEEERREQQEERREQQERREQQEERREQQLRREQEERREQQLRR 353

Query: 624 EADRQELQDELRQEREARQKLEMMIKELKLQ 654
           E + +  + +LR+E+E  ++ + + +E +L+
Sbjct: 354 EQEEERREQQLRREQEEERREQQLRREQQLR 384



 Score = 41.6 bits (96), Expect = 0.002
 Identities = 36/167 (21%), Positives = 87/167 (52%), Gaps = 14/167 (8%)

Query: 499  KDVICEDDKGKIMEEVMRTYLKQQEKLNLILQKKQQLQMEVKMLSSSKSMKELTEEQQNL 558
            + ++ E+ + +  +E  + Y +++E    + Q+++QL  E +     +  +    ++  L
Sbjct: 971  EQLLGEEPEKRRRQEREKKYREEEE----LQQEEEQLLREEREKRRRQEWERQYRKKDEL 1026

Query: 559  QKELESLQNEHA-----QRMEEFYVEQKDLEKKLEQIMKQKCTCDSNLEKDKEAEYAGQL 613
            Q+E E L  E       Q  E  Y E+++L+++ EQ++ ++   ++   ++ E +Y  + 
Sbjct: 1027 QQEEEQLLREEREKRRLQERERQYREEEELQQEEEQLLGEER--ETRRRQELERQYRKE- 1083

Query: 614  AELRQRLDHAEADRQELQDELRQEREARQKLEMMIKELKLQILKSSK 660
             EL+Q  +  +  R+E +   RQERE + + E  +++ + Q+L+  +
Sbjct: 1084 EELQQ--EEEQLLREEPEKRRRQERERQCREEEELQQEEEQLLREER 1128



 Score = 40.8 bits (94), Expect = 0.004
 Identities = 32/143 (22%), Positives = 75/143 (52%), Gaps = 10/143 (6%)

Query: 504 EDDKGKIMEEVMRTYLKQQEKLNLILQKKQQLQMEVKMLSSSKSMKELTEEQQNLQKELE 563
           E+   K+  + +R   +++E+    L+++QQL+   K     +  +E   EQQ  +++ E
Sbjct: 275 EEQLRKLERQELRRERQEEEQQQQRLRREQQLRR--KQEEERREQQEERREQQERREQQE 332

Query: 564 SLQNEHAQRMEEFYVEQKDLEKKLEQIMKQKCTCDSNLEKDKEAEYAGQLAELRQRLDHA 623
             + +  +R +E   E+++ + + EQ  +++   +  L +++E E   Q     Q+L   
Sbjct: 333 ERREQQLRREQE---ERREQQLRREQEEERR---EQQLRREQEEERREQQLRREQQLRRE 386

Query: 624 EADRQELQDELRQEREARQKLEM 646
           +  R+E Q  LR+E++ R++ ++
Sbjct: 387 QQLRREQQ--LRREQQLRREQQL 407



 Score = 40.8 bits (94), Expect = 0.004
 Identities = 31/149 (20%), Positives = 73/149 (48%), Gaps = 17/149 (11%)

Query: 512 EEVMRTYLKQQEKLNLILQKKQQLQMEVKMLSSSKSMKELTEEQQNLQKELESLQNEHAQ 571
           +E  R   +++EK    L++++QLQ   +        ++L EE+  LQ++ E  +++  +
Sbjct: 817 KEQRRRQRREREKELQFLEEEEQLQRRERA-------QQLQEEEDGLQEDQERRRSQEQR 869

Query: 572 RMEEFYVEQKDLEKKLEQIMKQKCTCDSNLEKDKEAEYAGQLAELRQRLDHAEADRQELQ 631
           R +++  + ++  K+    +  K      L K+++      L E     +  E  R+E +
Sbjct: 870 RDQKWRWQLEEERKRRRHTLYAKPALQEQLRKEQQL-----LQE-----EEEELQREERE 919

Query: 632 DELRQEREARQKLEMMIKELKLQILKSSK 660
              RQE+E + + E  +++ + Q+L+  +
Sbjct: 920 KRRRQEQERQYREEEQLQQEEEQLLREER 948



 Score = 40.0 bits (92), Expect = 0.007
 Identities = 34/134 (25%), Positives = 68/134 (50%), Gaps = 18/134 (13%)

Query: 512 EEVMRTYLKQQEKLNLILQKKQQLQMEVKMLSSSKSMKELTEEQQNLQKELESLQNEHAQ 571
           E  +R   +QQ +   + +++++ Q   +     K ++ L EE+Q LQ+       E AQ
Sbjct: 795 ERQLRAEERQQREQRFLPEEEEKEQRRRQRREREKELQFLEEEEQ-LQR------RERAQ 847

Query: 572 RMEEFYVEQKDLEKKLEQIMKQKCTCDSNLEKDKEAEYAGQLAELRQRLDHAEADRQELQ 631
           +++E   E+  L++  E+   Q        E+ ++ ++  QL E R+R  H    +  LQ
Sbjct: 848 QLQE---EEDGLQEDQERRRSQ--------EQRRDQKWRWQLEEERKRRRHTLYAKPALQ 896

Query: 632 DELRQEREARQKLE 645
           ++LR+E++  Q+ E
Sbjct: 897 EQLRKEQQLLQEEE 910



 Score = 40.0 bits (92), Expect = 0.007
 Identities = 30/134 (22%), Positives = 71/134 (52%), Gaps = 13/134 (9%)

Query: 521  QQEKLNLILQKKQQLQMEVKMLSSSKSMKELTEEQQNLQKELESLQNEHAQRMEEFYVEQ 580
            QQE+  L+ +++++ + + +     K  K   +E+Q L +E E  +    Q  E+ Y E+
Sbjct: 937  QQEEEQLLREEREKRRRQERERQYRKDKKLQQKEEQLLGEEPEKRRR---QEREKKYREE 993

Query: 581  KDLEKKLEQIMKQKCTCDSNLEKDKEAEYAGQLAELRQRLDHAEADRQELQDELRQEREA 640
            ++L+++ EQ+++++       EK +  E+  Q     ++ D  + + ++L  E R++R  
Sbjct: 994  EELQQEEEQLLREE------REKRRRQEWERQY----RKKDELQQEEEQLLREEREKRRL 1043

Query: 641  RQKLEMMIKELKLQ 654
            +++     +E +LQ
Sbjct: 1044 QERERQYREEEELQ 1057



 Score = 39.3 bits (90), Expect = 0.012
 Identities = 29/150 (19%), Positives = 78/150 (52%), Gaps = 5/150 (3%)

Query: 499 KDVICEDDKGKIMEEVMRTYLKQQEKLNLILQKKQQLQMEVKMLSSSKSMKELTEEQQNL 558
           ++ +   ++ K+ EE  +   + QE+    L+K ++ ++  +     +  + L  EQQ  
Sbjct: 249 RETVLRKEEEKLQEEEPQRQRELQEEEEQ-LRKLERQELRRERQEEEQQQQRLRREQQLR 307

Query: 559 QKELESLQNEHAQRMEEFYVEQKDLEKKLEQIMK-QKCTCDSNLEKDKEAEYAGQLAELR 617
           +K+ E  + +  +R E+    ++  E++ +Q+ + Q+   +  L +++E E   Q  +LR
Sbjct: 308 RKQEEERREQQEERREQQERREQQEERREQQLRREQEERREQQLRREQEEERREQ--QLR 365

Query: 618 QRLDHAEADRQ-ELQDELRQEREARQKLEM 646
           +  +    ++Q   + +LR+E++ R++ ++
Sbjct: 366 REQEEERREQQLRREQQLRREQQLRREQQL 395



 Score = 39.3 bits (90), Expect = 0.012
 Identities = 32/128 (25%), Positives = 63/128 (49%), Gaps = 8/128 (6%)

Query: 520 KQQEKLNLILQKKQQLQMEVKMLSSSKSMKELTEE--QQNLQKELESLQNEHAQRMEEFY 577
           +QQE+     +++QQL+ E +     +  +E  EE  +Q L++E E  + E   R E+  
Sbjct: 329 EQQEE-----RREQQLRREQEERREQQLRREQEEERREQQLRREQEEERREQQLRREQQL 383

Query: 578 VEQKDLEKKLEQIMKQKCTCDSNLEKDKEAEYAGQLAELRQRLDHAEADRQELQDELRQE 637
             ++ L ++ +   +Q+   +  L ++++     QL   +Q     E +R E + E ++ 
Sbjct: 384 RREQQLRREQQLRREQQLRREQQLRREQQLRREQQLRREQQLRREQEEERHEQKHE-QER 442

Query: 638 REARQKLE 645
           RE R K E
Sbjct: 443 REQRLKRE 450



 Score = 38.9 bits (89), Expect = 0.015
 Identities = 35/144 (24%), Positives = 71/144 (49%), Gaps = 7/144 (4%)

Query: 518 YLKQQEKLNLILQKKQQLQMEVKMLSSSKSMKELTEEQQNLQKELESLQNEHAQRMEEFY 577
           +L+++E+L    ++ QQLQ E   L   +  +  ++EQ+  QK    L+ E  +R    Y
Sbjct: 833 FLEEEEQLQR-RERAQQLQEEEDGLQEDQERRR-SQEQRRDQKWRWQLEEERKRRRHTLY 890

Query: 578 VE---QKDLEKKLEQIMKQKCTCD-SNLEKDKEAEYAGQLAELRQ-RLDHAEADRQELQD 632
            +   Q+ L K+ + + +++        EK +  E   Q  E  Q + +  +  R+E + 
Sbjct: 891 AKPALQEQLRKEQQLLQEEEEELQREEREKRRRQEQERQYREEEQLQQEEEQLLREEREK 950

Query: 633 ELRQEREARQKLEMMIKELKLQIL 656
             RQERE + + +  +++ + Q+L
Sbjct: 951 RRRQERERQYRKDKKLQQKEEQLL 974



 Score = 38.9 bits (89), Expect = 0.015
 Identities = 28/160 (17%), Positives = 80/160 (50%), Gaps = 2/160 (1%)

Query: 504  EDDKGKIMEEVMRTYLKQQEKLNLILQKKQQLQMEVKMLSSSKSMKELTEEQQNLQKELE 563
            +D   K  EE      +++++L+   ++ ++ ++E + +   +  ++  E++Q L+++ E
Sbjct: 1551 QDRDRKFREEEQLRQEREEQQLSR-QERDRKFRLEEQKVRRQEQERKFMEDEQQLRRQ-E 1608

Query: 564  SLQNEHAQRMEEFYVEQKDLEKKLEQIMKQKCTCDSNLEKDKEAEYAGQLAELRQRLDHA 623
              Q    +R  +F  +++ L+++ EQ + ++      LE++ +     +  +LR   D  
Sbjct: 1609 GQQQLRQERDRKFREDEQLLQEREEQQLHRQERDRKFLEEEPQLRRQEREQQLRHDRDRK 1668

Query: 624  EADRQELQDELRQEREARQKLEMMIKELKLQILKSSKTAK 663
              + ++L  E  +++  RQ+ +   +E + Q+ +  +  K
Sbjct: 1669 FREEEQLLQEGEEQQLRRQERDRKFREEEQQLRRQERERK 1708



 Score = 38.5 bits (88), Expect = 0.020
 Identities = 34/140 (24%), Positives = 69/140 (49%), Gaps = 29/140 (20%)

Query: 520  KQQEKLNLILQKKQQLQMEVKMLSSSKSMKELTEEQQNLQKELESLQNE-----HAQRME 574
            +++E+L    Q+++QL  E +     + ++    E++ +Q+E E L  E       Q +E
Sbjct: 1111 REEEELQ---QEEEQLLREEREKRRRQELERQYREEEEVQQEEEQLLREEPEKRRRQELE 1167

Query: 575  EFYVEQKDLEKKLEQIMKQKCTCDSNLEKDKEAEYAGQLAELRQRLDHAEADRQELQDEL 634
              Y E+++L+++ EQ++++        E++K           RQ  +    + +ELQ   
Sbjct: 1168 RQYREEEELQQEEEQLLRE--------EQEKR----------RQERERQYREEEELQ--- 1206

Query: 635  RQEREARQKLEMMIKELKLQ 654
            RQ+R+ R + E    +LK Q
Sbjct: 1207 RQKRKQRYRDEDQRSDLKWQ 1226



 Score = 38.1 bits (87), Expect = 0.026
 Identities = 36/154 (23%), Positives = 70/154 (45%), Gaps = 16/154 (10%)

Query: 520 KQQEKLNLILQKKQQLQMEVKMLSSSKSMKELTEEQQNLQKELESLQNEHAQRMEE---F 576
           +QQ +    L+++QQL+ E ++    +  +E  EE+   + E E  +    +  EE   +
Sbjct: 398 EQQLRREQQLRREQQLRREQQLRREQQLRREQEEERHEQKHEQERREQRLKREQEERRDW 457

Query: 577 YVEQKDLEKKLEQIMKQKCTCDSNLE------KDKEAEYAGQLAELRQRLDHAEADR--- 627
              +++ E+  ++  KQ+   D   E      K +E E   Q     Q+L   + +R   
Sbjct: 458 LKREEETERHEQERRKQQLKRDQEEERRERWLKLEEEERREQQERREQQLRREQEERREQ 517

Query: 628 ----QELQDELRQEREARQKLEMMIKELKLQILK 657
               QE ++ L+Q   + Q+L    +E + Q+LK
Sbjct: 518 RLKRQEEEERLQQRLRSEQQLRREQEERREQLLK 551



 Score = 38.1 bits (87), Expect = 0.026
 Identities = 34/129 (26%), Positives = 66/129 (51%), Gaps = 3/129 (2%)

Query: 519  LKQQEKLNLILQKKQQLQ-MEVKMLSSSKSMKELTEEQQNLQKELESLQNEHAQRMEEFY 577
            L++QE+     +++Q  Q  E + L S +S ++  EE+Q L++E E  Q    QR  ++ 
Sbjct: 1764 LRRQERDRKFREEEQLRQEREEQQLRSQESDRKFREEEQ-LRQEREEQQLRPQQRDGKYR 1822

Query: 578  VEQKDLE-KKLEQIMKQKCTCDSNLEKDKEAEYAGQLAELRQRLDHAEADRQELQDELRQ 636
             E++ L+ ++ EQ ++Q+       E+    +   +  E     +  +  RQE + +LR+
Sbjct: 1823 WEEEQLQLEEQEQRLRQERDRQYRAEEQFATQEKSRREEQELWQEEEQKRRQERERKLRE 1882

Query: 637  EREARQKLE 645
            E   RQ+ E
Sbjct: 1883 EHIRRQQKE 1891



 Score = 37.7 bits (86), Expect = 0.034
 Identities = 31/126 (24%), Positives = 69/126 (54%), Gaps = 17/126 (13%)

Query: 530 QKKQQLQMEVKMLSSSKS--MKELTEEQQNLQKEL--------ESLQNEHAQRMEEFYVE 579
           Q++++ + E + L S K    +E  +E+Q  ++EL        E  Q +  +R +  + E
Sbjct: 181 QEREERRAEEEQLQSCKGHETEEFPDEEQLRRRELLELRRKGREEKQQQRRERQDRVFQE 240

Query: 580 QKDLE-KKLEQIMKQKCTCDSNLEKDKEAEYAGQLAELRQRLDHAEADRQELQDELRQER 638
           +++ E +K E +++++   +  L+++ E +   +L E  ++L   E  RQEL+ E ++E 
Sbjct: 241 EEEKEWRKRETVLRKE---EEKLQEE-EPQRQRELQEEEEQLRKLE--RQELRRERQEEE 294

Query: 639 EARQKL 644
           + +Q+L
Sbjct: 295 QQQQRL 300



 Score = 37.7 bits (86), Expect = 0.034
 Identities = 39/147 (26%), Positives = 77/147 (52%), Gaps = 9/147 (6%)

Query: 520 KQQEKLNLILQKKQQLQMEVKMLSSSKSMKE--LTEEQQNLQKELESLQNEHAQRMEEFY 577
           +QQ +    L+++QQL+ E ++    +  +E  L  EQQ  +++    + +  +  EE  
Sbjct: 374 EQQLRREQQLRREQQLRREQQLRREQQLRREQQLRREQQLRREQQLRREQQLRREQEEER 433

Query: 578 VEQKDLEKKLEQIMKQKCTCDSN-LEKDKEAEYAGQLAELRQRLDHAEADRQE----LQD 632
            EQK  +++ EQ +K++     + L++++E E   Q    +Q     E +R+E    L++
Sbjct: 434 HEQKHEQERREQRLKREQEERRDWLKREEETERHEQERRKQQLKRDQEEERRERWLKLEE 493

Query: 633 ELRQEREAR--QKLEMMIKELKLQILK 657
           E R+E++ R  Q+L    +E + Q LK
Sbjct: 494 EERREQQERREQQLRREQEERREQRLK 520



 Score = 37.4 bits (85), Expect = 0.045
 Identities = 30/133 (22%), Positives = 66/133 (49%), Gaps = 11/133 (8%)

Query: 530 QKKQQLQMEVKMLSSSKSMKELTEE---------QQNLQKELESLQNEHAQRMEEFYVEQ 580
           +++QQL+ E +     + ++   EE         +Q L++E + L+ E   R E+    +
Sbjct: 346 RREQQLRREQEEERREQQLRREQEEERREQQLRREQQLRRE-QQLRREQQLRREQQLRRE 404

Query: 581 KDLEKKLEQIMKQKCTCDSNLEKDKEAEYAGQLAELRQRLDHAEADRQELQDELRQEREA 640
           + L ++ +   +Q+   +  L +++E E   Q  E  +R    + +++E +D L++E E 
Sbjct: 405 QQLRREQQLRREQQLRREQQLRREQEEERHEQKHEQERREQRLKREQEERRDWLKREEET 464

Query: 641 -RQKLEMMIKELK 652
            R + E   ++LK
Sbjct: 465 ERHEQERRKQQLK 477



 Score = 37.4 bits (85), Expect = 0.045
 Identities = 30/159 (18%), Positives = 78/159 (49%), Gaps = 8/159 (5%)

Query: 503  CEDDKGKIMEEVMRTYLKQQEKLNLILQKKQQLQMEVKMLSSSKSMKELTEEQQ------ 556
            C++ + ++ ++  R + +++++L+   + ++  + E ++    +  K L EEQQ      
Sbjct: 1401 CQEREQQLRQDRDRKFREEEQQLSRQERDRKFREEEQQVRRQERERKFLEEEQQLRQERH 1460

Query: 557  -NLQKELESLQNEHAQRMEEFYVEQKDLEKKLEQIMKQKCTCDSNLEKDKEAEYAGQLAE 615
               ++E + LQ    Q++     ++K LE++ +Q+ +Q+       ++ +  E   +  E
Sbjct: 1461 RKFREEEQLLQEREEQQLHRQERDRKFLEEE-QQLRRQERDRKFREQELRSQEPERKFLE 1519

Query: 616  LRQRLDHAEADRQELQDELRQEREARQKLEMMIKELKLQ 654
              Q+L   +  R+ LQ+E +  R+ R +     ++ K +
Sbjct: 1520 EEQQLHRQQRQRKFLQEEQQLRRQERGQQRRQDRDRKFR 1558



 Score = 36.6 bits (83), Expect = 0.076
 Identities = 35/131 (26%), Positives = 67/131 (51%), Gaps = 14/131 (10%)

Query: 530 QKKQQLQMEVKMLSSSKSMKELTEEQQNLQKELESLQNEHAQRMEEFYVEQKDLEKKLEQ 589
           QK+Q+ + E+         +E +E+Q+ L++     ++E   R  + + E++  E++ E+
Sbjct: 139 QKRQEQERELA------EGEEQSEKQERLEQRDRQRRDEELWRQRQEWQERE--ERRAEE 190

Query: 590 IMKQKCTCDSNLE-KDKEAEYAGQLAELRQR-LDHAEADRQELQDELRQEREARQ--KLE 645
              Q C      E  D+E     +L ELR++  +  +  R+E QD + QE E ++  K E
Sbjct: 191 EQLQSCKGHETEEFPDEEQLRRRELLELRRKGREEKQQQRRERQDRVFQEEEEKEWRKRE 250

Query: 646 MMIK--ELKLQ 654
            +++  E KLQ
Sbjct: 251 TVLRKEEEKLQ 261



 Score = 36.6 bits (83), Expect = 0.076
 Identities = 34/142 (23%), Positives = 68/142 (47%), Gaps = 9/142 (6%)

Query: 504  EDDKGKIMEEVMRTYLKQQEKLNLILQKKQQLQMEVKMLSSSKSMKELTEEQQNLQKELE 563
            E+++ + +E+      + Q+ L  +L ++Q+   E +     +  +   EE+Q     LE
Sbjct: 1246 ENEQFRQLEDSQLRDRQSQQDLQHLLGEQQERDREQERRRWQQRDRHFPEEEQ-----LE 1300

Query: 564  SLQNEHAQRMEEFYVEQKDLEKKLEQIMKQKCTCDSNLEKDKEAEYAGQLAELRQRLDHA 623
              + + A+R +    E+K L ++  +  +++   D    K +E E   Q  E  Q L   
Sbjct: 1301 REEQKEAKRRDRKSQEEKQLLREEREEKRRRQETD---RKFREEEQLLQERE-EQPLRRQ 1356

Query: 624  EADRQELQDELRQEREARQKLE 645
            E DR+  ++ELR + + R+ LE
Sbjct: 1357 ERDRKFREEELRHQEQGRKFLE 1378



 Score = 36.2 bits (82), Expect = 0.100
 Identities = 33/147 (22%), Positives = 72/147 (48%), Gaps = 12/147 (8%)

Query: 512 EEVMRTYLKQQEKLNLILQKKQQLQMEVKMLSSSKSMKELTEEQQNLQKELESLQNEHAQ 571
           EE       +QE+    L+++Q+ + +           E    +Q L+++ E  + E   
Sbjct: 430 EEERHEQKHEQERREQRLKREQEERRDWLKREEETERHEQERRKQQLKRDQEEERRERWL 489

Query: 572 RMEEFYVEQKDLEKKLEQIMK--QKCTCDSNLEKDKEAEYAGQLAELRQRLDHAEADRQE 629
           ++EE   E+++ +++ EQ ++  Q+   +  L++ +E E       L+QRL   +  R+E
Sbjct: 490 KLEE--EERREQQERREQQLRREQEERREQRLKRQEEEE------RLQQRLRSEQQLRRE 541

Query: 630 LQDELRQ--EREARQKLEMMIKELKLQ 654
            ++   Q  +RE  ++LE   +E +L+
Sbjct: 542 QEERREQLLKREEEKRLEQERREQRLK 568



 Score = 35.8 bits (81), Expect = 0.13
 Identities = 33/114 (28%), Positives = 59/114 (51%), Gaps = 10/114 (8%)

Query: 551 LTEEQQNLQKELESLQNEHAQRMEEFYVEQKD--LEKKLEQIMKQKCTCDSNLEKDKEAE 608
           L EE++      ESL  +  Q  ++   E +D  LE++  Q  +QK       E+++E  
Sbjct: 95  LDEEKRARCDGKESLLQDRRQEEDQRRFEPRDRQLEEEPGQRRRQK-----RQEQERELA 149

Query: 609 YAGQLAELRQRLDHAEADRQELQDEL-RQEREARQKLEMMIKELKLQILKSSKT 661
              + +E ++RL+  + DRQ   +EL RQ +E +++ E   +E +LQ  K  +T
Sbjct: 150 EGEEQSEKQERLE--QRDRQRRDEELWRQRQEWQEREERRAEEEQLQSCKGHET 201



 Score = 35.0 bits (79), Expect = 0.22
 Identities = 26/126 (20%), Positives = 65/126 (51%), Gaps = 3/126 (2%)

Query: 520 KQQEKLNLILQKKQQLQMEVKMLSSSKSMKELTEEQQNLQKELESLQNEHAQRMEEFYVE 579
           ++QE+     Q++++ Q E +     +  ++L  EQ+  +++    + E  +R ++   E
Sbjct: 308 RKQEEERREQQEERREQQERREQQEERREQQLRREQEERREQQLRREQEEERREQQLRRE 367

Query: 580 QKDLEKKLEQIMKQKCTCDSNLEKDKEAEYAGQLAELRQRLDHAEADRQELQDELRQERE 639
           Q++  ++ +   +Q+   +  L ++++     QL    Q+L   +  R+E Q  LR+E++
Sbjct: 368 QEEERREQQLRREQQLRREQQLRREQQLRREQQLRR-EQQLRREQQLRREQQ--LRREQQ 424

Query: 640 ARQKLE 645
            R++ E
Sbjct: 425 LRREQE 430



 Score = 35.0 bits (79), Expect = 0.22
 Identities = 34/171 (19%), Positives = 83/171 (48%), Gaps = 12/171 (7%)

Query: 502 ICEDDKGKIMEEVMRTYLKQQEKLNLILQKKQ-QLQMEVKMLSSSKSMKELTEEQQNLQK 560
           + E+++ +  E +     K Q +L      +Q ++    +     +  +E  E+++  + 
Sbjct: 685 LAEEEQEQARERIKSRIPKWQWQLESEADARQSKVYSRPRKQEGQRRRQEQEEKRRRRES 744

Query: 561 ELESLQNEHAQRMEEFYVEQKDL------EKKLEQIMKQKCTCDSNLEKDKEAEYAGQLA 614
           EL+  + E A R ++   +++D       E+K E+  +Q+ +    L + +E +     A
Sbjct: 745 ELQWQEEERAHRQQQEEEQRRDFTWQWQAEEKSER-GRQRLSARPPLREQRERQLR---A 800

Query: 615 ELRQRLDHAEADRQELQDELRQEREARQK-LEMMIKELKLQILKSSKTAKE 664
           E RQ+ +      +E +++ R++R  R+K L+ + +E +LQ  + ++  +E
Sbjct: 801 EERQQREQRFLPEEEEKEQRRRQRREREKELQFLEEEEQLQRRERAQQLQE 851



 Score = 35.0 bits (79), Expect = 0.22
 Identities = 27/130 (20%), Positives = 65/130 (50%), Gaps = 3/130 (2%)

Query: 519  LKQQEKLNLILQKKQQLQMEV--KMLSSSKSMKELTEEQQNLQ-KELESLQNEHAQRMEE 575
            +++QE+    L+++QQL+ E   K     + ++E  E+Q + Q ++ + L+ E   R +E
Sbjct: 1439 VRRQERERKFLEEEQQLRQERHRKFREEEQLLQEREEQQLHRQERDRKFLEEEQQLRRQE 1498

Query: 576  FYVEQKDLEKKLEQIMKQKCTCDSNLEKDKEAEYAGQLAELRQRLDHAEADRQELQDELR 635
               + ++ E + ++  ++    +  L + +      Q  +  +R +  +  RQ+   + R
Sbjct: 1499 RDRKFREQELRSQEPERKFLEEEQQLHRQQRQRKFLQEEQQLRRQERGQQRRQDRDRKFR 1558

Query: 636  QEREARQKLE 645
            +E + RQ+ E
Sbjct: 1559 EEEQLRQERE 1568



 Score = 34.7 bits (78), Expect = 0.29
 Identities = 40/171 (23%), Positives = 83/171 (48%), Gaps = 28/171 (16%)

Query: 512 EEVMRTYLKQQEKLNLILQKKQQLQMEVKMLSSSKSMKELTEEQQNLQKELE-------- 563
           +++ R   +++ +  L L+++++ + + +     +  +E   EQ+  ++E E        
Sbjct: 474 QQLKRDQEEERRERWLKLEEEERREQQERREQQLRREQEERREQRLKRQEEEERLQQRLR 533

Query: 564 ---SLQNEHAQRMEEFYVEQKDLEKKLEQIMK-------QKCTCDSNLEKDKEAEY---- 609
               L+ E  +R E+    +++ EK+LEQ  +       Q+   D  L++++E       
Sbjct: 534 SEQQLRREQEERREQLL--KREEEKRLEQERREQRLKREQEERRDQLLKREEERRQQRLK 591

Query: 610 AGQLAELRQRLDHAEADRQELQDELRQEREARQKLEMMIKELKLQILKSSK 660
             Q   L QRL   E +R E Q+E R++R  R++ E   +E + Q+LKS +
Sbjct: 592 REQEERLEQRLKREEVERLE-QEERREQRLKREEPE---EERRQQLLKSEE 638



 Score = 34.3 bits (77), Expect = 0.38
 Identities = 31/143 (21%), Positives = 67/143 (46%), Gaps = 3/143 (2%)

Query: 521  QQEKLNLILQKKQQLQMEVKMLSSSKSMKELTEEQQNLQKELESLQNEHAQRMEEFYVEQ 580
            ++E+L    Q ++ L+ E ++    +  K L EEQQ   +E E  Q     R  +F  E+
Sbjct: 1363 REEELRHQEQGRKFLEEEQRLRRQERERKFLKEEQQLRCQERE--QQLRQDRDRKFREEE 1420

Query: 581  KDLEKKLEQIMKQKCTCDSNLEKDKEAEYAGQLAELRQRLDHAEADRQELQDELRQEREA 640
            + L ++ E+  K +        +++E ++  +  +LRQ       + ++L  E  +++  
Sbjct: 1421 QQLSRQ-ERDRKFREEEQQVRRQERERKFLEEEQQLRQERHRKFREEEQLLQEREEQQLH 1479

Query: 641  RQKLEMMIKELKLQILKSSKTAK 663
            RQ+ +    E + Q+ +  +  K
Sbjct: 1480 RQERDRKFLEEEQQLRRQERDRK 1502



 Score = 33.9 bits (76), Expect = 0.49
 Identities = 27/154 (17%), Positives = 77/154 (50%), Gaps = 11/154 (7%)

Query: 499  KDVICEDDKGKIMEEVMRTYLKQQEKLNLILQKKQQLQMEVKMLSSSKSMKELTEEQQNL 558
            ++ +  +++ K  +E  R Y +++E   L  QK++Q   +    S  K   E  +E    
Sbjct: 1180 EEQLLREEQEKRRQERERQYREEEE---LQRQKRKQRYRDEDQRSDLKWQWEPEKENAVR 1236

Query: 559  QKEL--ESLQNEHAQRMEEFYVEQKDLEKKLEQIMKQKCTCDSNLEKDKEAEYAGQLAEL 616
              ++  +  +NE  +++E+  +  +  ++ L+ ++ ++       E+D+E E        
Sbjct: 1237 DNKVYCKGRENEQFRQLEDSQLRDRQSQQDLQHLLGEQ------QERDREQERRRWQQRD 1290

Query: 617  RQRLDHAEADRQELQDELRQEREARQKLEMMIKE 650
            R   +  + +R+E ++  R++R+++++ +++ +E
Sbjct: 1291 RHFPEEEQLEREEQKEAKRRDRKSQEEKQLLREE 1324



 Score = 33.9 bits (76), Expect = 0.49
 Identities = 32/158 (20%), Positives = 80/158 (50%), Gaps = 5/158 (3%)

Query: 512  EEVMRTYLKQQEKLNLILQKKQQLQMEVKMLSSSKSMKELTEEQQNLQKELESLQNEHAQ 571
            +E  R +L+++ +L    +++Q      +     + + +  EEQQ  ++E +    E  Q
Sbjct: 1639 QERDRKFLEEEPQLRRQEREQQLRHDRDRKFREEEQLLQEGEEQQLRRQERDRKFREEEQ 1698

Query: 572  RMEEFYVEQKDLEKKLE---QIMKQKCTCDSNLEKDKEAEYAGQLAELRQRLDHAEADRQ 628
            ++     E+K L+++ +   Q +++K   +  L ++ E E   +    R+ L+  +   +
Sbjct: 1699 QLRRQERERKFLQEEQQLRRQELERKFREEEQLRQETEQEQLRRQERYRKILEEEQLRPE 1758

Query: 629  ELQDEL-RQEREAR-QKLEMMIKELKLQILKSSKTAKE 664
              + +L RQER+ + ++ E + +E + Q L+S ++ ++
Sbjct: 1759 REEQQLRRQERDRKFREEEQLRQEREEQQLRSQESDRK 1796



 Score = 32.7 bits (73), Expect = 1.1
 Identities = 34/152 (22%), Positives = 72/152 (47%), Gaps = 17/152 (11%)

Query: 520 KQQEKLNLILQKKQQLQMEV--KMLSSSKSMKELTEEQQNLQK----ELESLQNEHAQRM 573
           +Q EK   + Q+ +Q + E   +     +  +E   E++ LQ     E E   +E   R 
Sbjct: 153 EQSEKQERLEQRDRQRRDEELWRQRQEWQEREERRAEEEQLQSCKGHETEEFPDEEQLRR 212

Query: 574 EEFY-VEQKDLEKKLEQIMKQKCTCDSNLEKDKEAEYAGQLAELRQRLDHAEADRQELQD 632
            E   + +K  E+K +Q  +++   D   ++++E E+  +   LR+       + ++LQ+
Sbjct: 213 RELLELRRKGREEKQQQRRERQ---DRVFQEEEEKEWRKRETVLRK-------EEEKLQE 262

Query: 633 ELRQEREARQKLEMMIKELKLQILKSSKTAKE 664
           E  Q +   Q+ E  +++L+ Q L+  +  +E
Sbjct: 263 EEPQRQRELQEEEEQLRKLERQELRRERQEEE 294



 Score = 32.7 bits (73), Expect = 1.1
 Identities = 37/177 (20%), Positives = 93/177 (52%), Gaps = 18/177 (10%)

Query: 499 KDVICEDDKGKIMEEVMRTYLK--QQEKLNLILQKKQQL-QMEVKMLSSSKSMKELT-EE 554
           + ++  +++ ++ +E     LK  Q+E+ + +L+++++  Q  +K     +  + L  EE
Sbjct: 547 EQLLKREEEKRLEQERREQRLKREQEERRDQLLKREEERRQQRLKREQEERLEQRLKREE 606

Query: 555 QQNLQKE------LESLQNEHAQRMEEFYVEQKDLEKKLEQIMKQKCTCDSNLEKDKEAE 608
            + L++E      L+  + E  +R +    E+++  ++ +   +Q+   +  L++++E E
Sbjct: 607 VERLEQEERREQRLKREEPEEERRQQLLKSEEQEERRQQQLRREQQERREQRLKREEEEE 666

Query: 609 YAGQLAELRQRLDHAEADR-QELQDELRQEREARQKLEMMIKELKLQILKSSKTAKE 664
                 E R + +H E  R QEL +E  ++ +AR++++  I + + Q L+S   A++
Sbjct: 667 ----RLEQRLKREHEEERREQELAEE--EQEQARERIKSRIPKWQWQ-LESEADARQ 716



 Score = 32.7 bits (73), Expect = 1.1
 Identities = 34/143 (23%), Positives = 74/143 (51%), Gaps = 14/143 (9%)

Query: 519  LKQQEKLNLILQKKQQLQMEVKMLSSSKSMKELTEEQ--QNLQKELESLQNEHAQRMEEF 576
            L+++E+  L  Q++ +   E ++    +  K L EEQ  +  ++E + L+ E   R +E 
Sbjct: 1345 LQEREEQPLRRQERDRKFREEELRHQEQGRKFLEEEQRLRRQERERKFLKEEQQLRCQE- 1403

Query: 577  YVEQKDLEKKLEQIMKQKCTCDSNLEKDKEAEYAGQLAELRQRLDHAEADRQELQDE--L 634
               ++ L +  ++  +++    S  E+D+      +  E  Q++   E +R+ L++E  L
Sbjct: 1404 --REQQLRQDRDRKFREEEQQLSRQERDR------KFREEEQQVRRQERERKFLEEEQQL 1455

Query: 635  RQEREAR-QKLEMMIKELKLQIL 656
            RQER  + ++ E +++E + Q L
Sbjct: 1456 RQERHRKFREEEQLLQEREEQQL 1478


>gi|31982906 cingulin-like 1 [Homo sapiens]
          Length = 1302

 Score = 53.9 bits (128), Expect = 5e-07
 Identities = 66/280 (23%), Positives = 133/280 (47%), Gaps = 44/280 (15%)

Query: 396 TSAVSQSKELTKTEASKSISRQSEKAHSSGKLQKTVSYPDVSLEEQEKMDLKTSRELCSR 455
           T+ +      T T       + S K   S     T + PD+ L+ Q+++  +T+ E   +
Sbjct: 501 TATLMLQNRATATSPDSGAKKISVKTFPSAS--NTQATPDL-LKGQQELTQQTNEETAKQ 557

Query: 456 L------DASISNNSTSKRKSESATCNLVRDINKVGIGLVAAASSPLLVKDVICEDDKGK 509
           +      + S  N+  +KRK      NLV +  +    L + A+      +  C      
Sbjct: 558 ILYNYLKEGSTDNDDATKRK-----VNLVFEKIQT---LKSRAAGSAQGNNQACNSTSE- 608

Query: 510 IMEEVMRTYLKQQEKLNL-ILQKKQQLQMEVKMLSSSKSMKELTEEQQNLQKELESLQNE 568
                ++  L+Q+ KL + + + ++QLQ+EVK      + + + EE++ ++  LE L+++
Sbjct: 609 -----VKDLLEQKSKLTIEVAELQRQLQLEVK------NQQNIKEERERMRANLEELRSQ 657

Query: 569 HAQRMEEFYVEQKDLE-------KKLEQIMKQKCTCDSNLEKDKEAEYAGQLAELRQRLD 621
           H +++EE    Q+ LE       K LE++ + K   + +  + ++ +   QL+E+   LD
Sbjct: 658 HNEKVEENSTLQQRLEESEGELRKNLEELFQVKMEREQHQTEIRDLQ--DQLSEMHDELD 715

Query: 622 HAE--ADRQE--LQDELRQEREARQKLEMMIKELKLQILK 657
            A+   DR++  L +EL Q ++  Q L ++ KE +  +L+
Sbjct: 716 SAKRSEDREKGALIEELLQAKQDLQDL-LIAKEEQEDLLR 754



 Score = 47.8 bits (112), Expect = 3e-05
 Identities = 69/262 (26%), Positives = 114/262 (43%), Gaps = 30/262 (11%)

Query: 416  RQSEKAHSSGKLQKTVSYPDVS---LEEQEKMDLKTSRELCSRLD------ASISNNSTS 466
            R+ E     G L++ VS  D     L+EQ   +L+  RE            AS SN S  
Sbjct: 756  RERELTALKGALKEEVSSHDQEMDKLKEQYDAELQALRESVEEATKNVEVLASRSNTSEQ 815

Query: 467  KRKSESATCNLVRDINKVGIGLVAAASSPLLVKDVICEDDKGKIMEEVMRTYLKQQEKLN 526
             +        L+++ N+   G        +       ED KG   E   +  LK+ E   
Sbjct: 816  DQAGTEMRVKLLQEENEKLQGRSEELERRVAQLQRQIEDLKGD--EAKAKETLKKYEG-- 871

Query: 527  LILQKKQQLQMEVKMLSSSKSMKELTEEQQNLQKELESLQNEHAQRMEEFYVEQKDLEKK 586
                  +  Q+E  ++ + K  KE    ++ L+ ELE+ Q   +Q  +    EQK L +K
Sbjct: 872  ------EIRQLEEALVHARKEEKEAVSARRALENELEAAQGNLSQTTQ----EQKQLSEK 921

Query: 587  LEQIMKQKCTCDS-NLEKDKEAEYAGQLAELRQR--LDHAEADRQ---ELQDELRQEREA 640
            L++  +QK        E + E  + G+  E  Q+   D  EA R    ELQ++L + +E 
Sbjct: 922  LKEESEQKEQLRRLKNEMENERWHLGKTIEKLQKEMADIVEASRTSTLELQNQLDEYKEK 981

Query: 641  -RQKLEMMIKELKLQILKSSKT 661
             R++L  M ++LK + L++ K+
Sbjct: 982  NRRELAEMQRQLKEKTLEAEKS 1003



 Score = 47.4 bits (111), Expect = 4e-05
 Identities = 78/391 (19%), Positives = 165/391 (42%), Gaps = 77/391 (19%)

Query: 321  EKKLKIILEEMKEKFSMRSGKRN------QSKTDAPSGMELQSWYPVIKQEGDHVSQTHS 374
            E ++K++ EE  EK   RS +        Q + +   G E ++   + K EG+      +
Sbjct: 821  EMRVKLLQEE-NEKLQGRSEELERRVAQLQRQIEDLKGDEAKAKETLKKYEGEIRQLEEA 879

Query: 375  FLHP--------SYYLYMCDKVVAPNVSLTSAVSQSKELTK-----TEASKSISR-QSEK 420
             +H         S    + +++ A   +L+    + K+L++     +E  + + R ++E 
Sbjct: 880  LVHARKEEKEAVSARRALENELEAAQGNLSQTTQEQKQLSEKLKEESEQKEQLRRLKNEM 939

Query: 421  AHSSGKLQKTVSYPDVSLEEQEKMDLKTSRELCSRLDASISNNSTSKRKSESATCNLVRD 480
             +    L KT+      + +  +    ++ EL ++LD         K K+      + R 
Sbjct: 940  ENERWHLGKTIEKLQKEMADIVEASRTSTLELQNQLDEY-------KEKNRRELAEMQRQ 992

Query: 481  INKVGIGLVAAASSPLLVKDVICEDDKGKIMEEVMRTYLKQQE----KLNLILQKKQQLQ 536
            + +  +    +  + + ++D +      ++MEE +R Y + Q+    K  L+ Q  + L+
Sbjct: 993  LKEKTLEAEKSRLTAMKMQDEM------RLMEEELRDYQRAQDEALTKRQLLEQTLKDLE 1046

Query: 537  MEVKMLSS-----SKSMKELTEEQQNLQKELESLQNEH---AQRMEEFYVEQKDLEKKL- 587
             E++  S      S+ +K++ ++   L+ ELE  +N     ++R+     + + L  +L 
Sbjct: 1047 YELEAKSHLKDDRSRLVKQMEDKVSQLEMELEEERNNSDLLSERISRSREQMEQLRNELL 1106

Query: 588  -EQIMKQKCTCDS-NLEKDKE---------------------AEYAGQLAELRQRLDHAE 624
             E+  +Q   CD  +LE+  +                      +   ++AEL  RL+  E
Sbjct: 1107 QERAARQDLECDKISLERQNKDLKSRIIHLEGSYRSSKEGLVVQMEARIAELEDRLESEE 1166

Query: 625  ADRQELQDELRQEREARQKLEMMIKELKLQI 655
             DR  LQ        + ++LE  +KEL +Q+
Sbjct: 1167 RDRANLQ-------LSNRRLERKVKELVMQV 1190



 Score = 42.4 bits (98), Expect = 0.001
 Identities = 51/193 (26%), Positives = 92/193 (47%), Gaps = 33/193 (17%)

Query: 504  EDDKGKIMEEVMRTYLKQQEKLNLILQKKQ------QLQMEVKMLSSSKSM---KELTEE 554
            + +   I+E    + L+ Q +L+   +K +      Q Q++ K L + KS     ++ +E
Sbjct: 954  QKEMADIVEASRTSTLELQNQLDEYKEKNRRELAEMQRQLKEKTLEAEKSRLTAMKMQDE 1013

Query: 555  QQNLQKELESLQNEHAQRM-EEFYVEQ--KDLEKKLE----------QIMKQKCTCDSNL 601
             + +++EL   Q    + + +   +EQ  KDLE +LE          +++KQ     S L
Sbjct: 1014 MRLMEEELRDYQRAQDEALTKRQLLEQTLKDLEYELEAKSHLKDDRSRLVKQMEDKVSQL 1073

Query: 602  EKDKEAEYAGQLAELRQRLDHAEADRQELQDELRQEREARQ-------KLEMMIKELKLQ 654
            E + E E       L +R+  +    ++L++EL QER ARQ        LE   K+LK +
Sbjct: 1074 EMELEEE-RNNSDLLSERISRSREQMEQLRNELLQERAARQDLECDKISLERQNKDLKSR 1132

Query: 655  ILK---SSKTAKE 664
            I+    S +++KE
Sbjct: 1133 IIHLEGSYRSSKE 1145



 Score = 42.0 bits (97), Expect = 0.002
 Identities = 77/374 (20%), Positives = 146/374 (39%), Gaps = 54/374 (14%)

Query: 318  TPEEKKLKIILEEMKEKFSMRSGKRNQSKTDAPSGMELQSWYPVIKQEGDHVSQTHSFLH 377
            T E+K+L   L+E  E+       +N+        ME + W         H+ +T   L 
Sbjct: 912  TQEQKQLSEKLKEESEQKEQLRRLKNE--------MENERW---------HLGKTIEKLQ 954

Query: 378  PSYYLYMCDKVVAPNVS---LTSAVSQSKELTKTEASKSISRQSEKAHSSGKLQKTVS-- 432
                  M D V A   S   L + + + KE  + E ++   +  EK   + K + T    
Sbjct: 955  KE----MADIVEASRTSTLELQNQLDEYKEKNRRELAEMQRQLKEKTLEAEKSRLTAMKM 1010

Query: 433  YPDVSLEEQEKMDLK-------TSRELCSRLDASISNNSTSKRKSESATCNLVRDINKVG 485
              ++ L E+E  D +       T R+L  +    +     +K   +     LV+ +    
Sbjct: 1011 QDEMRLMEEELRDYQRAQDEALTKRQLLEQTLKDLEYELEAKSHLKDDRSRLVKQMEDKV 1070

Query: 486  IGLVAAASSPLLVKDVICED-DKGKIMEEVMRTYLKQQ---------EKLNLILQKKQQL 535
              L           D++ E   + +   E +R  L Q+         +K++L  Q K   
Sbjct: 1071 SQLEMELEEERNNSDLLSERISRSREQMEQLRNELLQERAARQDLECDKISLERQNKDLK 1130

Query: 536  QMEVKMLSSSKSMKE-LTEEQQNLQKELESLQNEHAQRMEEFYVEQKDLEKKLEQIMKQK 594
               + +  S +S KE L  + +    ELE       +      +  + LE+K+++++ Q 
Sbjct: 1131 SRIIHLEGSYRSSKEGLVVQMEARIAELEDRLESEERDRANLQLSNRRLERKVKELVMQV 1190

Query: 595  CTCDSNLEKDKEA------EYAGQLAELRQRLDHAEADRQELQDELRQEREARQKLE--- 645
                 +L   K+           Q+ E  + +D  E+ +++LQ EL ++ +  + L+   
Sbjct: 1191 DDEHLSLTDQKDQLSLRLKAMKRQVEEAEEEIDRLESSKKKLQRELEEQMDMNEHLQGQL 1250

Query: 646  -MMIKELKLQILKS 658
              M K+L+L+ L S
Sbjct: 1251 NSMKKDLRLKKLPS 1264


>gi|148596984 golgi autoantigen, golgin subfamily b, macrogolgin (with
            transmembrane signal), 1 [Homo sapiens]
          Length = 3259

 Score = 53.9 bits (128), Expect = 5e-07
 Identities = 42/173 (24%), Positives = 89/173 (51%), Gaps = 24/173 (13%)

Query: 516  RTYLKQQEKLNLILQKKQQLQMEVKMLSSSKSMK----ELTEEQQNLQKELESLQNEHAQ 571
            R  L Q+E+  LI +  + L     + SS +S+K     LTE+++ L KE+ESL++    
Sbjct: 1540 RLALLQEERDKLITEMDRSLLENQSLSSSCESLKLALEGLTEDKEKLVKEIESLKSSKIA 1599

Query: 572  RMEEFYVEQKDLEKKLEQIMKQKCTCDSNLE---------KDKEAEYAGQL-------AE 615
               E+  + K+L+K+ E +++      +  E         + ++ E  G+L        E
Sbjct: 1600 ESTEWQEKHKELQKEYEILLQSYENVSNEAERIQHVVEAVRQEKQELYGKLRSTEANKKE 1659

Query: 616  LRQRLDHAEADRQELQDELRQEREARQKLEMMIKE----LKLQILKSSKTAKE 664
              ++L  AE + +E+++++R+  +++Q+  + ++E    L+ ++  +  TAKE
Sbjct: 1660 TEKQLQEAEQEMEEMKEKMRKFAKSKQQKILELEEENDRLRAEVHPAGDTAKE 1712



 Score = 46.6 bits (109), Expect = 7e-05
 Identities = 70/342 (20%), Positives = 137/342 (40%), Gaps = 78/342 (22%)

Query: 384  MCDKVVAPNVSLTSAVSQSK--------ELTKTEAS--------KSISRQSEKA-HSSGK 426
            +CD +   N  L S + +++        EL K E+           +S   EK     G 
Sbjct: 2278 VCDTLQGENKELLSQLEETRHLYHSSQNELAKLESELKSLKDQLTDLSNSLEKCKEQKGN 2337

Query: 427  LQKTVSYPDVSLE------EQEKMDLKTSRELCSRLDASISNNS-------TSKRKSESA 473
            L+  +   +  ++      EQ + DL+ SREL SRL   I+          + K ++   
Sbjct: 2338 LEGIIRQQEADIQNSKFSYEQLETDLQASRELTSRLHEEINMKEQKIISLLSGKEEAIQV 2397

Query: 474  TCNLVRDINKVGIGLVAAASSPLLVKDVICEDDKGKIMEEVMRTYLKQQEKLNLILQKKQ 533
                +R  +   I  +    S    ++++ E++  K +++  +      E L  I  KK+
Sbjct: 2398 AIAELRQQHDKEIKELENLLSQEEEENIVLEEENKKAVDKTNQL----METLKTI--KKE 2451

Query: 534  QLQMEVKMLSSSKSM---------------------------------------KELTEE 554
             +Q + ++ S  KSM                                        +L EE
Sbjct: 2452 NIQQKAQLDSFVKSMSSLQNDRDRIVGDYQQLEERHLSIILEKDQLIQEAAAENNKLKEE 2511

Query: 555  QQNLQKELESLQNEHAQRMEEFYVEQKDLEKKLE-QIMKQKCTCDSNLEKDKEAEYAGQL 613
             + L+  ++ L +E+A+   E    ++DL + +  +  +QK   +  L+++KE E   + 
Sbjct: 2512 IRGLRSHMDDLNSENAKLDAELIQYREDLNQVITIKDSQQKQLLEVQLQQNKELE--NKY 2569

Query: 614  AELRQRLDHAEADRQELQDELRQEREARQKLEMMIKELKLQI 655
            A+L ++L  +E   ++L+      +E +Q L   I+ LK+ I
Sbjct: 2570 AKLEEKLKESEEANEDLRRSFNALQEEKQDLSKEIESLKVSI 2611



 Score = 45.8 bits (107), Expect = 1e-04
 Identities = 65/314 (20%), Positives = 132/314 (42%), Gaps = 55/314 (17%)

Query: 387  KVVAPNVSLTSAVSQSKELTKTEASKS---ISRQSEKAHSSGKLQKTVSYPDVSLEEQEK 443
            +V+A N+ L   +  +KE  K++  +    + R+ E+A      +K           QEK
Sbjct: 2093 RVLADNLKLKKELQSNKESVKSQMKQKDEDLERRLEQAEEKHLKEKK--------NMQEK 2144

Query: 444  MDLKTSRELCSRLDASISNNSTSKRKSESATCNLVRDINKVGIGLVAAASSPLLVKDVIC 503
            +D     ++   L+ +I     +  K +     L  +++     L A   S   +     
Sbjct: 2145 LDALRREKV--HLEETIGEIQVTLNKKDKEVQQLQENLDSTVTQLAAFTKSMSSL----- 2197

Query: 504  EDDKGKIMEEVMRTYLKQQEKL------------NLILQKKQQLQMEVKM------LSSS 545
            +DD+ ++++E  +   K  + +            N  + K Q  QM + M      +S  
Sbjct: 2198 QDDRDRVIDEAKKWERKFSDAIQSKEEEIRLKEDNCSVLKDQLRQMSIHMEELKINISRL 2257

Query: 546  KSMKELTE-----EQQNLQKELESLQNEHAQRMEE-------FYVEQKDL---EKKLEQI 590
            +  K++ E     E Q  QK  ++LQ E+ + + +       ++  Q +L   E +L+ +
Sbjct: 2258 EHDKQIWESKAQTEVQLQQKVCDTLQGENKELLSQLEETRHLYHSSQNELAKLESELKSL 2317

Query: 591  MKQKCTCDSNLEKDKE--AEYAGQLAELRQRLDHAEADRQELQDELRQEREARQKL--EM 646
              Q     ++LEK KE      G + +    + +++   ++L+ +L+  RE   +L  E+
Sbjct: 2318 KDQLTDLSNSLEKCKEQKGNLEGIIRQQEADIQNSKFSYEQLETDLQASRELTSRLHEEI 2377

Query: 647  MIKELKLQILKSSK 660
             +KE K+  L S K
Sbjct: 2378 NMKEQKIISLLSGK 2391



 Score = 43.1 bits (100), Expect = 8e-04
 Identities = 77/377 (20%), Positives = 157/377 (41%), Gaps = 53/377 (14%)

Query: 321  EKKLKIILEEMKEKFSMRSGKRNQSKTDAPSGMELQSWYPVIKQEGDHVSQTHSFLHPSY 380
            E+  + I  E +E+ S+    R       PS    +S  P + ++     + ++      
Sbjct: 1787 EEGTQSIPGETEEQDSLSMSTRPTCSESVPSA---KSANPAVSKDFSSHDEINN------ 1837

Query: 381  YLYMCDKVVAPNVSLTSAVSQSKELTKTEASKSISRQSEKAHSSGKLQKTVSYPDVSLEE 440
            YL   D++      L     ++KE ++T  ++  +  S+ +   G+L+       +  EE
Sbjct: 1838 YLQQIDQLKERIAGLEEEKQKNKEFSQTLENEKNTLLSQISTKDGELK-------MLQEE 1890

Query: 441  QEKMDLKTSR--ELCSRLDASISNNSTSKRKSESATCNLVRDINKVGIGLVAAASSPLLV 498
              KM+L   +  E  SR+          K   E    N + ++N   IG      +   +
Sbjct: 1891 VTKMNLLNQQIQEELSRVTKLKETAEEEKDDLEERLMNQLAELNG-SIGNYCQDVTDAQI 1949

Query: 499  KDVICEDDKGKI------MEEVMRTYLKQQEKLNL-----ILQKKQQLQMEVKMLSSSKS 547
            K+ + E +   +      +EE  +  +K++ K+        L+K Q  Q E    S +K 
Sbjct: 1950 KNELLESEMKNLKKCVSELEEEKQQLVKEKTKVESEIRKEYLEKIQGAQKEPGNKSHAKE 2009

Query: 548  MKELTEEQQNLQKELE----------SLQNEHAQRMEEFYVE-QKDLE---KKLEQIMKQ 593
            ++EL +E+Q   K+L+          S      + +E    E QKDLE   + L Q ++ 
Sbjct: 2010 LQELLKEKQQEVKQLQKDCIRYQEKISALERTVKALEFVQTESQKDLEITKENLAQAVEH 2069

Query: 594  KCTCDSNLEK------DKEAEYAGQLAELRQRLDHAEADRQELQDELRQEREARQKLEMM 647
            +    + L        D ++E A  LA+  +     +++++ ++ +++Q+ E    LE  
Sbjct: 2070 RKKAQAELASFKVLLDDTQSEAARVLADNLKLKKELQSNKESVKSQMKQKDE---DLERR 2126

Query: 648  IKELKLQILKSSKTAKE 664
            +++ + + LK  K  +E
Sbjct: 2127 LEQAEEKHLKEKKNMQE 2143



 Score = 41.2 bits (95), Expect = 0.003
 Identities = 57/264 (21%), Positives = 116/264 (43%), Gaps = 37/264 (14%)

Query: 395  LTSAVSQSKELTKTEASKSISRQSEKAHSSGKLQKTVSYPD-----VSLEEQEKMDLKTS 449
            L+ A+SQ KEL  T+  + +    EK      LQ+T+   D     +S    EKM     
Sbjct: 864  LSQALSQ-KELEITKMDQLLL---EKKRDVETLQQTIEEKDQQVTEISFSMTEKMVQLNE 919

Query: 450  RELCSRLDA-SISNNSTSKRKSESATCNLVRDINKVGIGLVAAASSPLLVKDVICEDDKG 508
             +    ++  ++        ++E A    V + N+V  GL                   G
Sbjct: 920  EKFSLGVEIKTLKEQLNLLSRAEEAKKEQVEEDNEVSSGLKQNYDEM---------SPAG 970

Query: 509  KIMEEVMRTYLKQQEKLNLILQKKQQLQMEVKMLSSSKSMKELTEEQQNLQKELESLQNE 568
            +I +E +      Q + +L+  KK+  Q + K+ ++  + KEL +    L++EL +L++E
Sbjct: 971  QISKEEL------QHEFDLL--KKENEQRKRKLQAALINRKELLQRVSRLEEELANLKDE 1022

Query: 569  HAQRMEEFYVEQKDLEK-KLEQIMKQKCTCDSNLEKDKEAEYAGQLAELRQRLDHAEADR 627
              + +     E+ ++E+ K  +   +KC       K +E E       L+Q +   E + 
Sbjct: 1023 SKKEIPLSETERGEVEEDKENKEYSEKCV----TSKCQEIE-----IYLKQTISEKEVEL 1073

Query: 628  QELQDELRQEREARQKLEMMIKEL 651
            Q ++ +L ++  A ++ + ++K++
Sbjct: 1074 QHIRKDLEEKLAAEEQFQALVKQM 1097



 Score = 40.4 bits (93), Expect = 0.005
 Identities = 53/240 (22%), Positives = 106/240 (44%), Gaps = 33/240 (13%)

Query: 441  QEKMDLKTSRELCSRLDASISNNSTSKRKSESATCNLVRDINKVGIGLVAAASSPLLVKD 500
            Q K  LK        L+  +S+ ++   K       L   INK G+  + +  +     +
Sbjct: 1306 QIKAQLKEIEAEKVELELKVSSTTSELTKKSEEVFQLQEQINKQGLE-IESLKTVSHEAE 1364

Query: 501  VICEDDKGKIME--------EVMRTYLKQQEKLNLILQKKQQLQMEVKMLSSSKSMKE-- 550
            V  E  + K+          E +R    + ++L  ++ KK++   +V  LS   S KE  
Sbjct: 1365 VHAESLQQKLESSQLQIAGLEHLRELQPKLDELQKLISKKEE---DVSYLSGQLSEKEAA 1421

Query: 551  LTE------EQQNLQK----ELESLQNEHAQRMEEFYVEQKDLEKKLEQIMKQKCTCDSN 600
            LT+      EQ++L K    +LE    EH +R+++  VE  ++++K E+I +     +S 
Sbjct: 1422 LTKIQTEIIEQEDLIKALHTQLEMQAKEHDERIKQLQVELCEMKQKPEEIGE-----ESR 1476

Query: 601  LEKDKEAEYAGQLAELRQRLDHAEADRQELQDELRQEREARQKLEMMIKELKLQILKSSK 660
             ++  + +    L   ++ L     + + LQ+EL   R   ++L   + +++ Q+   +K
Sbjct: 1477 AKQQIQRKLQAALISRKEAL----KENKSLQEELSLARGTIERLTKSLADVESQVSAQNK 1532



 Score = 38.5 bits (88), Expect = 0.020
 Identities = 79/361 (21%), Positives = 156/361 (43%), Gaps = 45/361 (12%)

Query: 320  EEKKLKIILEEMKEKFSMRSGKRNQSKTDAPSGMELQSWYPVIKQEGDHVSQTHSFLHPS 379
            +++ L+  LE+ +EK  ++  K  Q K DA            +++E  H+ +T   +  +
Sbjct: 2119 KDEDLERRLEQAEEKH-LKEKKNMQEKLDA------------LRREKVHLEETIGEIQVT 2165

Query: 380  YYLYMCDKVVAP-NVSLTSAVSQSKELTKTEASKSISRQSEKAHSSGKLQKTVSYPDVSL 438
              L   DK V     +L S V+Q    TK+ +S    R      +    +K   + D   
Sbjct: 2166 --LNKKDKEVQQLQENLDSTVTQLAAFTKSMSSLQDDRDRVIDEAKKWERK---FSDAIQ 2220

Query: 439  EEQEKMDLKTSRELCSRLDASISNNSTSKRKSESATCNLVRDINKVGIGLVAAASSPLLV 498
             ++E++ LK     CS L   +   S    + +     L  D         + A + + +
Sbjct: 2221 SKEEEIRLKEDN--CSVLKDQLRQMSIHMEELKINISRLEHDKQI----WESKAQTEVQL 2274

Query: 499  KDVICEDDKGKI------MEEVMRTYLKQQEKLNLILQKKQQLQMEVKMLSSSKSMKELT 552
            +  +C+  +G+       +EE    Y   Q +L  +  + + L+ ++  LS+S  +++  
Sbjct: 2275 QQKVCDTLQGENKELLSQLEETRHLYHSSQNELAKLESELKSLKDQLTDLSNS--LEKCK 2332

Query: 553  EEQQNLQ----KELESLQNEHA--QRMEEFYVEQKDLEKKLEQIMKQKCTCDSNLEKDKE 606
            E++ NL+    ++   +QN     +++E      ++L  +L + +  K     +L   KE
Sbjct: 2333 EQKGNLEGIIRQQEADIQNSKFSYEQLETDLQASRELTSRLHEEINMKEQKIISLLSGKE 2392

Query: 607  AEYAGQLAELRQRLDHAEADRQELQDELRQEREARQKLEMMIK---ELKLQILKSSKTAK 663
                  +AELRQ+ D    + +EL++ L QE E    LE   K   +   Q++++ KT K
Sbjct: 2393 EAIQVAIAELRQQHD---KEIKELENLLSQEEEENIVLEEENKKAVDKTNQLMETLKTIK 2449

Query: 664  E 664
            +
Sbjct: 2450 K 2450



 Score = 37.7 bits (86), Expect = 0.034
 Identities = 59/290 (20%), Positives = 121/290 (41%), Gaps = 44/290 (15%)

Query: 399 VSQSKELTKTEASKSISRQSEK-AHSSGKLQKTVSYPDVSLEEQEKMDLKTSRELCSRLD 457
           + + +EL  T  ++    Q+E+ A SS ++++ V           K  L+   E  S L 
Sbjct: 153 LQEKEELISTLQAQLTQAQAEQPAQSSTEMEEFVMM---------KQQLQEKEEFISTLQ 203

Query: 458 ASISNNSTSKRKSESATCNLVRDINKVGIGLVAAASSPLLVKDVICEDDKGKIMEEVMRT 517
           A +S       ++E A   +VR+ +      V      LL   ++ + D    M++ +R 
Sbjct: 204 AQLSQT-----QAEQAAQQVVREKDARFETQVRLHEDELL--QLVTQADVETEMQQKLRV 256

Query: 518 YLKQ------------------QEKLNLILQKKQQLQMEVKMLSSSKSMKELTEEQQNLQ 559
             ++                  Q++L    Q+ Q L  +++ + +  +    T E +  +
Sbjct: 257 LQRKLEEHEESLVGRAQVVDLLQQELTAAEQRNQILSQQLQQMEAEHNTLRNTVETEREE 316

Query: 560 KE--LESLQNEHAQRMEEFYVEQKDLEKKLEQIMKQKCTCDSNLEKDKEAEYAGQLAELR 617
            +  LE ++ E A+R   F+  Q+++   LEQ  +Q     + LE    A      AE+ 
Sbjct: 317 SKILLEKMELEVAERKLSFHNLQEEMHHLLEQ-FEQAGQAQAELESRYSALEQKHKAEME 375

Query: 618 QRLDH---AEADRQELQDELRQEREARQKLEMMIKELKLQILKSSKTAKE 664
           ++  H    +   QELQ      ++   KL   +++   Q ++S++T ++
Sbjct: 376 EKTSHILSLQKTGQELQSACDALKDQNSKL---LQDKNEQAVQSAQTIQQ 422



 Score = 36.2 bits (82), Expect = 0.100
 Identities = 33/175 (18%), Positives = 80/175 (45%), Gaps = 31/175 (17%)

Query: 506  DKGKIMEEVMRTYLKQQEKLNLI---------LQKKQQLQMEVKMLSSSKSMKELTEEQQ 556
            +K + ++++ +  ++ QEK++ +         +Q + Q  +E+    + +++ +  E ++
Sbjct: 2016 EKQQEVKQLQKDCIRYQEKISALERTVKALEFVQTESQKDLEI----TKENLAQAVEHRK 2071

Query: 557  NLQKELESL-------QNEHAQRMEEFYVEQKDLEKKLEQIMKQKCTCDSNLEKDKEAEY 609
              Q EL S        Q+E A+ + +    +K+L+   E +  Q    D +LE+      
Sbjct: 2072 KAQAELASFKVLLDDTQSEAARVLADNLKLKKELQSNKESVKSQMKQKDEDLER------ 2125

Query: 610  AGQLAELRQRLDHAEADRQELQDELRQEREARQKLEMMIKELKLQILKSSKTAKE 664
                  L Q  +    +++ +Q++L   R  +  LE  I E+++ + K  K  ++
Sbjct: 2126 -----RLEQAEEKHLKEKKNMQEKLDALRREKVHLEETIGEIQVTLNKKDKEVQQ 2175



 Score = 35.8 bits (81), Expect = 0.13
 Identities = 56/256 (21%), Positives = 103/256 (40%), Gaps = 40/256 (15%)

Query: 415  SRQSEKAHSSGKLQKTVSYPDVSLEEQEKMDLKTSRELCSRLDASISNNSTSKRKSESAT 474
            S Q+ + H++ +L +     D SL+E  +  LK    L    DA +S  + S   +E  +
Sbjct: 2742 SLQNSRDHANEELDELKRKYDASLKELAQ--LKEQGLLNRERDALLSETAFSMNSTEENS 2799

Query: 475  CNLVRDINKVGIGLVAAASSPLLVKDVICEDDKGKIME--EVMRTYLKQQEKLNLILQK- 531
             + +  +N+     + +    LL      ED   ++    + M +   +++ L   L+K 
Sbjct: 2800 LSHLEKLNQQ----LLSKDEQLLHLSSQLEDSYNQVQSFSKAMASLQNERDHLWNELEKF 2855

Query: 532  -----------KQQLQMEVKMLSSSKSMKELTEEQQNLQKELESLQNEHAQRMEEFYVEQ 580
                        Q      ++ S  K+M  L  ++  L KEL++LQ ++ Q  +E   E 
Sbjct: 2856 RKSEEGKQRSAAQPSTSPAEVQSLKKAMSSLQNDRDRLLKELKNLQQQYLQINQEI-TEL 2914

Query: 581  KDLEKKLEQIMKQKCTCDSNLEKDKEAEYAGQLAELRQRLDHAEADRQELQDELRQEREA 640
              L+ +L++             +DK   +     ELRQ       +    Q EL Q R  
Sbjct: 2915 HPLKAQLQEY------------QDKTKAFQIMQEELRQ-------ENLSWQHELHQLRME 2955

Query: 641  RQKLEMMIKELKLQIL 656
            +   E+  + +K Q L
Sbjct: 2956 KSSWEIHERRMKEQYL 2971



 Score = 35.4 bits (80), Expect = 0.17
 Identities = 30/114 (26%), Positives = 51/114 (44%), Gaps = 4/114 (3%)

Query: 535  LQMEVKMLSSSKSMKELTEEQQNLQKELESLQNEHAQRMEEFYVEQKDLEKKLEQIMKQK 594
            ++ME K+L  +K  K LT + Q+  + + SLQN      EE    ++  +  L+++ + K
Sbjct: 2713 VEMEQKLLMVTKENKGLTAQIQSFGRSMSSLQNSRDHANEELDELKRKYDASLKELAQLK 2772

Query: 595  CTCDSNLEKD---KEAEYAGQLAELRQRLDHAEADRQELQDELRQEREARQKLE 645
                 N E+D    E  ++    E    L H E   Q+L  +  Q      +LE
Sbjct: 2773 EQGLLNRERDALLSETAFSMNSTE-ENSLSHLEKLNQQLLSKDEQLLHLSSQLE 2825



 Score = 34.7 bits (78), Expect = 0.29
 Identities = 53/241 (21%), Positives = 107/241 (44%), Gaps = 34/241 (14%)

Query: 386  DKVVAPNVSLTSAVSQSKELTK--TEASKSISRQSEKAHSSGKLQKTVSYPDVSLEEQEK 443
            D+ +  N SL+S+    K   +  TE  + + ++ E   SS K+ ++  + +   E Q++
Sbjct: 1556 DRSLLENQSLSSSCESLKLALEGLTEDKEKLVKEIESLKSS-KIAESTEWQEKHKELQKE 1614

Query: 444  MD-LKTSRELCSRLDASISNNSTSKRKSESATCNLVRDINKVGIGLVAAASSPLLVKDVI 502
             + L  S E  S     I +   + R+ +      +R            A+     K + 
Sbjct: 1615 YEILLQSYENVSNEAERIQHVVEAVRQEKQELYGKLRSTE---------ANKKETEKQLQ 1665

Query: 503  CEDDKGKIMEEVMRTYLK-QQEKLNLILQKKQQLQMEVK------------MLSSSKSMK 549
              + + + M+E MR + K +Q+K+  + ++  +L+ EV             +LSS+ SMK
Sbjct: 1666 EAEQEMEEMKEKMRKFAKSKQQKILELEEENDRLRAEVHPAGDTAKECMETLLSSNASMK 1725

Query: 550  ELTE----EQQNLQKELESLQNEHAQRMEEFYVEQKDLEKKLEQIMKQKCTCDSNLEKDK 605
            E  E    E + L K+ +SL +E     EE     +DL+ ++E  + ++   ++  + D 
Sbjct: 1726 EELERVKMEYETLSKKFQSLMSEKDSLSEEV----QDLKHQIEGNVSKQANLEATEKHDN 1781

Query: 606  E 606
            +
Sbjct: 1782 Q 1782



 Score = 34.3 bits (77), Expect = 0.38
 Identities = 60/341 (17%), Positives = 142/341 (41%), Gaps = 55/341 (16%)

Query: 329  EEMKEKFSMRSGKRNQSKTDAPSGM----ELQSWYPVIKQEGDHVSQT--HSFLHPSYYL 382
            E+++E   + SG +      +P+G     ELQ  + ++K+E +   +    + ++    L
Sbjct: 947  EQVEEDNEVSSGLKQNYDEMSPAGQISKEELQHEFDLLKKENEQRKRKLQAALINRKELL 1006

Query: 383  YMCDKVVAPNVSLTSAVSQSKELTKTEASKSISRQSEKAHS----SGKLQKTVSYPDVSL 438
                ++     +L     +   L++TE  +    +  K +S    + K Q+   Y   ++
Sbjct: 1007 QRVSRLEEELANLKDESKKEIPLSETERGEVEEDKENKEYSEKCVTSKCQEIEIYLKQTI 1066

Query: 439  EEQEKMDLKTSRELCSRLDASISNNSTSKRKSESATCNLVRDINKVGIGLVAAASSPLLV 498
             E+E       ++L  +L A     +  K+ +++    L    N++ +     + +  ++
Sbjct: 1067 SEKEVELQHIRKDLEEKLAAEEQFQALVKQMNQT----LQDKTNQIDLLQAEISENQAII 1122

Query: 499  KDVICEDDKGKIMEEVMRTYLKQQEKLNLILQKKQQLQMEVKMLSSSKSMK-ELTEEQQN 557
            + +I  +           T     + + L+   K+ + +      SS+  K EL E+   
Sbjct: 1123 QKLITSN-----------TDASDGDSVALV---KETVVISPPCTGSSEHWKPELEEKILA 1168

Query: 558  LQKELESLQNEHAQRMEEFYVEQKDLEKKLEQIMKQKCTCDSNLEKDKEAEYAGQLAELR 617
            L+KE E LQ    ++++E    +K + KK +             EK++          LR
Sbjct: 1169 LEKEKEQLQ----KKLQEALTSRKAILKKAQ-------------EKERH---------LR 1202

Query: 618  QRLDHAEADRQELQDELRQEREARQKLEMMIKELKLQILKS 658
            + L   + D   LQ++  ++ +  + +   +++L++Q+ +S
Sbjct: 1203 EELKQQKDDYNRLQEQFDEQSKENENIGDQLRQLQIQVRES 1243



 Score = 31.6 bits (70), Expect = 2.5
 Identities = 35/147 (23%), Positives = 65/147 (44%), Gaps = 15/147 (10%)

Query: 517  TYLKQQEKLNLILQKKQQLQMEVKMLSSSKSMKELTEEQQNLQKELESLQNEHAQRMEEF 576
            T    Q+K  L +Q +Q  ++E K     + +KE  E  ++L++   +LQ E     ++ 
Sbjct: 2545 TIKDSQQKQLLEVQLQQNKELENKYAKLEEKLKESEEANEDLRRSFNALQEE----KQDL 2600

Query: 577  YVEQKDLEKKLEQIMKQKCTCDSNLEKDKEAEYAGQL---AELRQRLDHAEADRQELQDE 633
              E + L+  + Q+ +Q        E+     Y  QL    E   RL    +  Q+   E
Sbjct: 2601 SKEIESLKVSISQLTRQVTALQ---EEGTLGLYHAQLKVKEEEVHRLSALFSSSQKRIAE 2657

Query: 634  LRQE-----REARQKLEMMIKELKLQI 655
            L +E     +EA +K+  +  +LK ++
Sbjct: 2658 LEEELVCVQKEAAKKVGEIEDKLKKEL 2684



 Score = 30.4 bits (67), Expect = 5.5
 Identities = 34/132 (25%), Positives = 59/132 (44%), Gaps = 12/132 (9%)

Query: 535  LQMEVKMLSSSKSMKELTEEQQNLQKELESLQNEHAQRMEEFYVEQKDLEKKLEQIMKQK 594
            LQ    +      +KE+  E+  L+ ++ S  +E  ++ EE +  Q       EQI KQ 
Sbjct: 1298 LQGGTSVAQIKAQLKEIEAEKVELELKVSSTTSELTKKSEEVFQLQ-------EQINKQG 1350

Query: 595  CTCDSNLEKDKEAEYAGQLAELRQRLDHAEADRQELQD--ELRQEREARQKLEMMIKELK 652
               +S      EAE   +   L+Q+L+ ++     L+   EL+ + +  QKL +  KE  
Sbjct: 1351 LEIESLKTVSHEAEVHAE--SLQQKLESSQLQIAGLEHLRELQPKLDELQKL-ISKKEED 1407

Query: 653  LQILKSSKTAKE 664
            +  L    + KE
Sbjct: 1408 VSYLSGQLSEKE 1419



 Score = 30.4 bits (67), Expect = 5.5
 Identities = 25/142 (17%), Positives = 64/142 (45%), Gaps = 8/142 (5%)

Query: 513  EVMRTYLKQQEKLNLILQKKQQLQMEVKMLSSSKSMKELTEEQQNLQKELESLQNEHAQR 572
            E+ R  ++ ++KL ++ ++ + L  +++  S  +SM  L   + +  +EL+ L+ ++   
Sbjct: 2707 ELARDLVEMEQKLLMVTKENKGLTAQIQ--SFGRSMSSLQNSRDHANEELDELKRKYDAS 2764

Query: 573  MEEF--YVEQKDLEKKLEQIMKQKCTCDSNLEKDKEAEYAGQLAELRQRLDHAEADRQEL 630
            ++E     EQ  L ++ + ++ +     ++ E++        L +L Q+L   +     L
Sbjct: 2765 LKELAQLKEQGLLNRERDALLSETAFSMNSTEENS----LSHLEKLNQQLLSKDEQLLHL 2820

Query: 631  QDELRQEREARQKLEMMIKELK 652
              +L       Q     +  L+
Sbjct: 2821 SSQLEDSYNQVQSFSKAMASLQ 2842



 Score = 29.6 bits (65), Expect = 9.3
 Identities = 78/372 (20%), Positives = 145/372 (38%), Gaps = 35/372 (9%)

Query: 312  NQKYLGTPEEKKLKII-LEEMKEKF-----SMRSGKRNQSKTDAPSGMELQSWYPVIKQE 365
            NQ    + E  KL +  L E KEK      S++S K  +S        ELQ  Y ++ Q 
Sbjct: 1562 NQSLSSSCESLKLALEGLTEDKEKLVKEIESLKSSKIAESTEWQEKHKELQKEYEILLQS 1621

Query: 366  GDHVS-QTHSFLHPSYYLYMCDKVVAPNVSLTSAVSQSKELTKTEASKSISRQSEKAHSS 424
             ++VS +     H    +    + +   +  T A  +  E    EA + +    EK    
Sbjct: 1622 YENVSNEAERIQHVVEAVRQEKQELYGKLRSTEANKKETEKQLQEAEQEMEEMKEKMR-- 1679

Query: 425  GKLQKTVSYPDVSLEEQE---KMDLKTSRELCSR-LDASISNNSTSKRKSESATCNLVRD 480
             K  K+     + LEE+    + ++  + +     ++  +S+N++ K + E         
Sbjct: 1680 -KFAKSKQQKILELEEENDRLRAEVHPAGDTAKECMETLLSSNASMKEELERVKME-YET 1737

Query: 481  INKVGIGLVAAASSPLLVKDVICEDDKGKIMEEVMRTYLKQQEKLNLILQKKQQLQMEVK 540
            ++K    L++   S  L ++V  +D K +I   V        ++ NL   +K   Q  V 
Sbjct: 1738 LSKKFQSLMSEKDS--LSEEV--QDLKHQIEGNV-------SKQANLEATEKHDNQTNVT 1786

Query: 541  MLSSSKSMKELTEEQQNLQKELESLQNEHA-------QRMEEFYVEQKDLEKKLEQIMKQ 593
                ++S+   TEEQ +L        +E           + + +    ++   L+QI + 
Sbjct: 1787 E-EGTQSIPGETEEQDSLSMSTRPTCSESVPSAKSANPAVSKDFSSHDEINNYLQQIDQL 1845

Query: 594  K-CTCDSNLEKDKEAEYAGQLAELRQRLDHAEADRQELQDELRQEREARQKLEMMIKELK 652
            K        EK K  E++  L   +  L    + +      L++E      L   I+E  
Sbjct: 1846 KERIAGLEEEKQKNKEFSQTLENEKNTLLSQISTKDGELKMLQEEVTKMNLLNQQIQEEL 1905

Query: 653  LQILKSSKTAKE 664
             ++ K  +TA+E
Sbjct: 1906 SRVTKLKETAEE 1917


>gi|239745095 PREDICTED: hypothetical protein LOC645202 [Homo
           sapiens]
          Length = 570

 Score = 53.5 bits (127), Expect = 6e-07
 Identities = 56/221 (25%), Positives = 97/221 (43%), Gaps = 20/221 (9%)

Query: 446 LKTSRELCSRLDASISNNSTSKRKSESATCNLVRDINKVGIGLVAAASSPLLVKDVICED 505
           L  S +    L+ ++S  +T K+K++     L ++ + + + L          ++ I + 
Sbjct: 155 LHDSWKFAGELEQALSAVATQKKKADRYIEELTKERDALSLELY---------RNTITD- 204

Query: 506 DKGKIMEEVMRTYLKQQEKLNLILQKKQQLQMEVKMLSSSKSMKELTEEQQNLQKELESL 565
                 EE+     K QEKL L+  +K ++Q+ VK L       +L   QQ LQ E + L
Sbjct: 205 ------EELKEKNAKLQEKLQLVESEKSEIQLNVKELKRKLERAKLLLPQQQLQAEADHL 258

Query: 566 QNE--HAQRMEEFYVEQKDLEKKLEQIMKQKCTCDSNLEKDKEAEYAGQLAELRQRLDHA 623
             E        +  VE+ +L  +L Q  ++K       EK +E E   Q  E + R    
Sbjct: 259 GKELQSVSAKLQAQVEENELWNRLNQQQEEKMWRQE--EKIQEREEKIQEQEEKIREQEE 316

Query: 624 EADRQELQDELRQEREARQKLEMMIKELKLQILKSSKTAKE 664
           +  RQE     ++E+  RQ+  M  KE K++ L+     +E
Sbjct: 317 KMRRQEEMMWEKEEKMRRQEEMMWEKEEKIRELEEKMHEQE 357



 Score = 47.4 bits (111), Expect = 4e-05
 Identities = 34/168 (20%), Positives = 88/168 (52%), Gaps = 5/168 (2%)

Query: 499 KDVICEDDKGKIMEEVMRTYLKQQEKLNLILQKKQQLQMEVKMLSSSKSMKELTEEQQNL 558
           ++ I E ++ +  EE +R   K+QE+   + +++++++ + + +   + M +  EE+   
Sbjct: 356 QEKIREQEEKRQEEEKIREQEKRQEQEAKMWRQEEKIREQEEKIREQEEMMQEQEEKMGE 415

Query: 559 QKELESLQNEHAQRMEEFYVEQKDLEKKLEQIMKQKCTCDSNLEKDKE--AEYAGQLAEL 616
           Q+E    Q E  Q  EE    Q++  ++ E+ ++++   +  + + +E   E   ++ E 
Sbjct: 416 QEEKMWEQEEEMQEQEEKMRRQEEKIREQEKKIREQ---EEKIREQEEMMQEQEEKMGEQ 472

Query: 617 RQRLDHAEADRQELQDELRQEREARQKLEMMIKELKLQILKSSKTAKE 664
             ++   EA  QE ++++R++ E  ++ E  I+E + +I +  +  +E
Sbjct: 473 EGKMCEQEAKMQEQEEKMRRQEEKIREQEKKIREQEEKIREQEEMMQE 520



 Score = 41.6 bits (96), Expect = 0.002
 Identities = 44/257 (17%), Positives = 123/257 (47%), Gaps = 15/257 (5%)

Query: 399 VSQSKELTKTEASKSISRQSEKAHSSGKLQKTVSYPDVSLEEQEKMDLKTS-RELCSRLD 457
           +++ ++    E  ++     E    + KLQ+ +      L E EK +++ + +EL  +L+
Sbjct: 186 LTKERDALSLELYRNTITDEELKEKNAKLQEKLQ-----LVESEKSEIQLNVKELKRKLE 240

Query: 458 ASISNNSTSKRKSESATCNLVRDINKVGIGLVAAASSPLLVKDVICEDDKGKIMEEVMRT 517
            +       +++ ++   +L +++  V   L A      L   +  + +     E++ R 
Sbjct: 241 RA--KLLLPQQQLQAEADHLGKELQSVSAKLQAQVEENELWNRLNQQQE-----EKMWRQ 293

Query: 518 YLKQQEKLNLILQKKQQLQMEVKMLSSSKSMKELTEEQQNLQKELESLQNEHAQRMEEFY 577
             K QE+   I +++++++ + + +   + M    EE+   Q+E+   + E  + +EE  
Sbjct: 294 EEKIQEREEKIQEQEEKIREQEEKMRRQEEMMWEKEEKMRRQEEMMWEKEEKIRELEEKM 353

Query: 578 VEQKDLEKKLEQIMKQKCTCDSNLEKDKEAEYAGQLAELRQRLDHAEADRQELQDELRQE 637
            EQ+ + ++ E+  +++   +    +++EA+   Q  ++R++ +      + +Q++  +E
Sbjct: 354 HEQEKIREQEEKRQEEEKIREQEKRQEQEAKMWRQEEKIREQEEKIREQEEMMQEQ--EE 411

Query: 638 REARQKLEMMIKELKLQ 654
           +   Q+ +M  +E ++Q
Sbjct: 412 KMGEQEEKMWEQEEEMQ 428



 Score = 41.2 bits (95), Expect = 0.003
 Identities = 34/152 (22%), Positives = 79/152 (51%), Gaps = 17/152 (11%)

Query: 504 EDDKGKIMEEVMRTYLKQQEKLNLILQKKQQLQMEVKMLSSSKSMKELTEEQQNLQKELE 563
           ++++ +  EE MR   +Q+EK+    Q+K+  + E K+    +  +E+ +EQ+    E E
Sbjct: 423 QEEEMQEQEEKMR---RQEEKIRE--QEKKIREQEEKI----REQEEMMQEQEEKMGEQE 473

Query: 564 SLQNEHAQRMEEFYVEQKDLEKKLEQIMKQKCTCDSNLEKDKEAEYAGQ-----LAELRQ 618
               E   +M+E   +++ + ++ E+I +Q+       EK +E E   Q     + E  +
Sbjct: 474 GKMCEQEAKMQE---QEEKMRRQEEKIREQEKKIREQEEKIREQEEMMQEQEEKMWEQEE 530

Query: 619 RLDHAEADRQELQDELRQEREARQKLEMMIKE 650
           ++   E   QE ++++R++ E  ++ E+ +++
Sbjct: 531 KMCEQEEKMQEQEEKMRRQEEKMREQEVRLRQ 562



 Score = 39.3 bits (90), Expect = 0.012
 Identities = 31/149 (20%), Positives = 77/149 (51%), Gaps = 14/149 (9%)

Query: 504 EDDKGKIMEEVMRTYLKQQEKLNLILQKKQQLQMEVKMLSSSKSMKELTEEQQNLQKELE 563
           +++K +  EE+M    +++EK+   L++K   Q +++     +  +E   EQ+  Q++  
Sbjct: 328 KEEKMRRQEEMM---WEKEEKIRE-LEEKMHEQEKIREQEEKRQEEEKIREQEKRQEQEA 383

Query: 564 SL--QNEHAQRMEEFYVEQKDLEKKLEQIMKQKCTCDSNLEKDKEAEYAGQLAELRQRLD 621
            +  Q E  +  EE   EQ+++ ++ E+ M +        +++K  E   ++ E  +++ 
Sbjct: 384 KMWRQEEKIREQEEKIREQEEMMQEQEEKMGE--------QEEKMWEQEEEMQEQEEKMR 435

Query: 622 HAEADRQELQDELRQEREARQKLEMMIKE 650
             E   +E + ++R++ E  ++ E M++E
Sbjct: 436 RQEEKIREQEKKIREQEEKIREQEEMMQE 464



 Score = 38.9 bits (89), Expect = 0.015
 Identities = 41/164 (25%), Positives = 79/164 (48%), Gaps = 7/164 (4%)

Query: 505 DDKGKIMEEVMRTYLKQQEKLNLILQKKQQLQMEVKMLSSSKSMKELTEEQQNLQKELES 564
           D  GK ++ V      Q E+  L  +  QQ   E KM    + ++E  E+ Q  ++++  
Sbjct: 256 DHLGKELQSVSAKLQAQVEENELWNRLNQQ--QEEKMWRQEEKIQEREEKIQEQEEKIRE 313

Query: 565 LQNEHAQRMEEFYVEQKDLEKKLEQIMKQKCTCDSNLE-KDKEAEYAGQLAELRQRLD-- 621
            Q E  +R EE   E+++  ++ E++M +K      LE K  E E   +  E RQ  +  
Sbjct: 314 -QEEKMRRQEEMMWEKEEKMRRQEEMMWEKEEKIRELEEKMHEQEKIREQEEKRQEEEKI 372

Query: 622 HAEADRQELQDEL-RQEREARQKLEMMIKELKLQILKSSKTAKE 664
             +  RQE + ++ RQE + R++ E + ++ ++   +  K  ++
Sbjct: 373 REQEKRQEQEAKMWRQEEKIREQEEKIREQEEMMQEQEEKMGEQ 416



 Score = 38.9 bits (89), Expect = 0.015
 Identities = 34/163 (20%), Positives = 81/163 (49%), Gaps = 9/163 (5%)

Query: 505 DDKGKIMEEVMRTYLKQQEKLNLILQKKQQLQMEVKMLSSSKSMKELTEEQQNLQKELES 564
           ++K +  EE +R   +Q+EK+    Q++   + E KM    + M E  E+ + L++++  
Sbjct: 301 EEKIQEQEEKIR---EQEEKMRR--QEEMMWEKEEKMRRQEEMMWEKEEKIRELEEKMHE 355

Query: 565 LQNEHAQRMEEFYVEQKDLEKKLEQIMKQKCTCDSNLEKDKEAEYAGQ---LAELRQRLD 621
            Q +  ++ E+   E+K  E++  Q  + K        +++E +   Q   + E  +++ 
Sbjct: 356 -QEKIREQEEKRQEEEKIREQEKRQEQEAKMWRQEEKIREQEEKIREQEEMMQEQEEKMG 414

Query: 622 HAEADRQELQDELRQEREARQKLEMMIKELKLQILKSSKTAKE 664
             E    E ++E++++ E  ++ E  I+E + +I +  +  +E
Sbjct: 415 EQEEKMWEQEEEMQEQEEKMRRQEEKIREQEKKIREQEEKIRE 457



 Score = 35.0 bits (79), Expect = 0.22
 Identities = 31/160 (19%), Positives = 75/160 (46%), Gaps = 30/160 (18%)

Query: 512 EEVMRTYLKQQ-EKLNLILQKKQQLQMEVKMLSSSKSMKELTEEQQNLQKELESLQNEHA 570
           +E +R  L+ Q + + ++  +K +LQM +                Q+  K+LE    +  
Sbjct: 106 QEALRRELEAQVQTIRILTCQKTELQMALYY-------------SQHAVKQLEGEARDLI 152

Query: 571 QRMEEFYVEQKDLEKKLEQIMKQKCTCDSNLE---KDKEA-------------EYAGQLA 614
            R+ + +    +LE+ L  +  QK   D  +E   K+++A             E   + A
Sbjct: 153 SRLHDSWKFAGELEQALSAVATQKKKADRYIEELTKERDALSLELYRNTITDEELKEKNA 212

Query: 615 ELRQRLDHAEADRQELQDELRQEREARQKLEMMIKELKLQ 654
           +L+++L   E+++ E+Q  +++ +   ++ ++++ + +LQ
Sbjct: 213 KLQEKLQLVESEKSEIQLNVKELKRKLERAKLLLPQQQLQ 252



 Score = 30.0 bits (66), Expect = 7.1
 Identities = 28/94 (29%), Positives = 49/94 (52%), Gaps = 7/94 (7%)

Query: 502 ICEDD-KGKIMEEVMRTYLKQQEKLNLILQKKQQLQMEVKMLSSSKSMKELTEEQQNLQK 560
           +CE + K +  EE MR   +Q+EK+    Q+K+  + E K+    + M+E  EE+   Q+
Sbjct: 476 MCEQEAKMQEQEEKMR---RQEEKIRE--QEKKIREQEEKIREQEEMMQE-QEEKMWEQE 529

Query: 561 ELESLQNEHAQRMEEFYVEQKDLEKKLEQIMKQK 594
           E    Q E  Q  EE    Q++  ++ E  ++Q+
Sbjct: 530 EKMCEQEEKMQEQEEKMRRQEEKMREQEVRLRQQ 563


>gi|71361682 nuclear mitotic apparatus protein 1 [Homo sapiens]
          Length = 2115

 Score = 53.5 bits (127), Expect = 6e-07
 Identities = 62/261 (23%), Positives = 113/261 (43%), Gaps = 31/261 (11%)

Query: 404 ELTKTEASKSISR--QSEKAHSSGKLQKTVSYPDVSLEEQEKMDLKTSRELCSRLDASIS 461
           EL K  +S S +       A   G + +T  +    L++Q    L   R     L+  ++
Sbjct: 183 ELQKVASSSSGNNFLSGSPASPMGDILQTPQFQMRRLKKQ----LADERSNRDELELELA 238

Query: 462 NNSTSKRKSESATCNLVRDINKVGIGLVAAASSPLLVKDVICEDDKGKIMEEVMRTYLKQ 521
            N     + ++    + + I+++ +     A+SPL  K++    DK + +   +   LKQ
Sbjct: 239 ENRKLLTEKDAQIAMMQQRIDRLALLNEKQAASPLEPKELEELRDKNESLTMRLHETLKQ 298

Query: 522 QEKLNLILQKKQQLQMEVKMLSS-----SKSMKELTEEQQNLQKELESLQNEHAQRMEEF 576
            + L     +K Q+  ++  LS      S  ++E     Q LQ  L  L  EH++  +E+
Sbjct: 299 CQDLKT---EKSQMDRKINQLSEENGDLSFKLREFASHLQQLQDALNELTEEHSKATQEW 355

Query: 577 YVEQKDLEKKLEQIMKQKCTCDSNLEKDKEAEYAGQLAELRQRLDHAEADRQELQDELRQ 636
             +Q  LEK+L   ++     D    ++K     G+L++L + L        +LQD   Q
Sbjct: 356 LEKQAQLEKELSAALQ-----DKKCLEEKNEILQGKLSQLEEHL-------SQLQDNPPQ 403

Query: 637 EREARQKLEMMIKELKLQILK 657
           E     K E++   L+L+ LK
Sbjct: 404 E-----KGEVLGDVLQLETLK 419



 Score = 52.8 bits (125), Expect = 1e-06
 Identities = 58/241 (24%), Positives = 113/241 (46%), Gaps = 25/241 (10%)

Query: 440 EQEKMDLKTSRELCSRLDASISNNSTSKRKSESATCNLVRDINKVGIGLVAAASSPLLVK 499
           E+EK  L +   L + L +SISN S +K + E A+      +       VA+ +S L   
Sbjct: 458 EEEKQQLSS---LITDLQSSISNLSQAKEELEQASQAHGARLT----AQVASLTSELTTL 510

Query: 500 DVICEDDKGKIMEEVMRTYLKQQEKLNLILQKKQQ---LQMEVKMLSSSKSMKELTEEQQ 556
           +   +    ++     +   KQ +    + Q++Q    L+ +V+ LSSS   KE  ++ +
Sbjct: 511 NATIQQQDQELAGLKQQAKEKQAQLAQTLQQQEQASQGLRHQVEQLSSSLKQKE--QQLK 568

Query: 557 NLQKELESLQNEHAQRM------EEFYVEQKDLE-KKLEQIMKQKCT----CDSNLEKDK 605
            + ++ E+ + +HAQ++       E  + ++D   K+LE + K+K          L+   
Sbjct: 569 EVAEKQEATRQDHAQQLATAAEEREASLRERDAALKQLEALEKEKAAKLEILQQQLQVAN 628

Query: 606 EAEYAGQLAELRQRLDHAEADR--QELQDELRQEREARQKLEMMIKELKLQILKSSKTAK 663
           EA  + Q +  + + + AE  R  +ELQ  +   R+ + + +  + EL+LQ+    + A 
Sbjct: 629 EARDSAQTSVTQAQREKAELSRKVEELQACVETARQEQHEAQAQVAELELQLRSEQQKAT 688

Query: 664 E 664
           E
Sbjct: 689 E 689



 Score = 40.0 bits (92), Expect = 0.007
 Identities = 49/258 (18%), Positives = 114/258 (44%), Gaps = 22/258 (8%)

Query: 399 VSQSKELTKTEASKSISRQSEKAHSSGKLQKTVSYPDVSLEEQEKMDLKTSRELCSRLDA 458
           V++ +E T+ + ++ ++  +E+  +S + +        +LE+++   L+  ++     + 
Sbjct: 570 VAEKQEATRQDHAQQLATAAEEREASLRERDAALKQLEALEKEKAAKLEILQQQLQVANE 629

Query: 459 SISNNSTSKRKSESATCNLVRDINKVGIGLVAAASSPLLVKDVICEDDKGKIMEEVMRTY 518
           +  +  TS  +++     L R + ++   +  A       +  + E      +E  +R+ 
Sbjct: 630 ARDSAQTSVTQAQREKAELSRKVEELQACVETARQEQHEAQAQVAE------LELQLRSE 683

Query: 519 LKQQEKLNLILQKKQQLQMEVKMLSSSKSMKE--LTEEQQNLQKELESLQNEHAQRMEEF 576
            ++  +   + Q+K QLQ +++ L  S  + +  L EE++     LE  Q   ++   E 
Sbjct: 684 QQKATEKERVAQEKDQLQEQLQALKESLKVTKGSLEEEKRRAADALEEQQRCISELKAET 743

Query: 577 --YVEQKDLEKK-LEQIMKQKCTCDSNLEKDKEAEYAGQLAELRQRLDHAEADRQELQDE 633
              VEQ   E+K LE+    +   ++ L++  EA  A             E  R+EL + 
Sbjct: 744 RSLVEQHKRERKELEEERAGRKGLEARLQQLGEAHQA-----------ETEVLRRELAEA 792

Query: 634 LRQEREARQKLEMMIKEL 651
           +  +  A  + E ++KE+
Sbjct: 793 MAAQHTAESECEQLVKEV 810



 Score = 39.7 bits (91), Expect = 0.009
 Identities = 43/175 (24%), Positives = 78/175 (44%), Gaps = 37/175 (21%)

Query: 504  EDDKGKIMEEVMRTYLKQQEKLNLILQKKQQLQMEVKMLSSSKSMKELTEE--------- 554
            E  K K++EE  R    Q+E+  L  Q +Q   +EV     +K ++EL+++         
Sbjct: 1513 EGAKVKVLEERQRF---QEERQKLTAQVEQ---LEVFQREQTKQVEELSKKLADSDQASK 1566

Query: 555  -QQNLQKELESLQNEHAQRMEEFYVEQKDLEKKLEQIMKQKCTCDSNLEKDKEAE-YAGQ 612
             QQ   K +++   E  Q  +    +  +L+ +L Q             K++ AE Y  Q
Sbjct: 1567 VQQQKLKAVQAQGGESQQEAQRLQAQLNELQAQLSQ-------------KEQAAEHYKLQ 1613

Query: 613  LAELRQRLDHAEADRQELQDELR-------QEREARQKLEMMIKELKLQILKSSK 660
            + + +   D  +   QELQ++LR       + +E R + E +  EL+   LK+ +
Sbjct: 1614 MEKAKTHYDAKKQQNQELQEQLRSLEQLQKENKELRAEAERLGHELQQAGLKTKE 1668



 Score = 38.1 bits (87), Expect = 0.026
 Identities = 46/177 (25%), Positives = 70/177 (39%), Gaps = 39/177 (22%)

Query: 522  QEKLNLILQKKQQLQMEVKML-----SSSKSMKELTEEQQNLQKELESLQNEHAQ----- 571
            QE L   L +K+    E+  L     +  K ++EL +  + L+++L   + EHA      
Sbjct: 1049 QEALAHALTEKEGKDQELAKLRGLEAAQIKELEELRQTVKQLKEQLAKKEKEHASGSGAQ 1108

Query: 572  ------------RMEEFYVEQKDLEKKLEQIMKQKCTCDSNLEKDKEAEYA--------- 610
                        ++E    E   LE   +Q  KQ+   DS LE+  EAE A         
Sbjct: 1109 SEAAGRTEPTGPKLEALRAEVSKLE---QQCQKQQEQADS-LERSLEAERASRAERDSAL 1164

Query: 611  ----GQLAELRQRLDHAEADRQELQDELRQEREARQKLEMMIKELKLQILKSSKTAK 663
                GQL E  Q L H+++     Q EL   R   Q       E K Q+ +  + A+
Sbjct: 1165 ETLQGQLEEKAQELGHSQSALASAQRELAAFRTKVQDHSKAEDEWKAQVARGRQEAE 1221



 Score = 36.2 bits (82), Expect = 0.100
 Identities = 54/307 (17%), Positives = 132/307 (42%), Gaps = 32/307 (10%)

Query: 363 KQEGDHVSQTHSFLHPSYYLYMCDKVVAPNVSLT------SAVSQSKELTKTEASKSISR 416
           K+E +  SQ H     +    +  ++   N ++       + + Q  +  + + ++++ +
Sbjct: 482 KEELEQASQAHGARLTAQVASLTSELTTLNATIQQQDQELAGLKQQAKEKQAQLAQTLQQ 541

Query: 417 QSEKA----HSSGKLQKTVSYPDVSLEEQEKMDLKTSRELCSRLDASISNNSTSKRKSES 472
           Q + +    H   +L  ++   +  L+E  +    T ++   +L  +      S R+ ++
Sbjct: 542 QEQASQGLRHQVEQLSSSLKQKEQQLKEVAEKQEATRQDHAQQLATAAEEREASLRERDA 601

Query: 473 ATCNLVRDINKVGIGLVAAASSPLLVKDV-ICEDDKGKIMEEVMRTYLKQQEKLNLILQK 531
           A   L        +    AA   +L + + +  + +      V +    Q+EK  L  +K
Sbjct: 602 ALKQLE------ALEKEKAAKLEILQQQLQVANEARDSAQTSVTQA---QREKAELS-RK 651

Query: 532 KQQLQMEVKMLSSSKSMKELTEEQQNLQKELESLQNEHAQRMEEFYVEQKDLEKKLEQIM 591
            ++LQ  V+  ++ +   E   +   L+ +L S Q +  ++ E    E+  L+++L+ + 
Sbjct: 652 VEELQACVE--TARQEQHEAQAQVAELELQLRSEQQKATEK-ERVAQEKDQLQEQLQALK 708

Query: 592 KQKCTCDSNLEKDKEAEYAGQLAELRQRLDHAEADRQELQDE-------LRQEREARQKL 644
           +       +LE++K    A  L E ++ +   +A+ + L ++       L +ER  R+ L
Sbjct: 709 ESLKVTKGSLEEEKRRA-ADALEEQQRCISELKAETRSLVEQHKRERKELEEERAGRKGL 767

Query: 645 EMMIKEL 651
           E  +++L
Sbjct: 768 EARLQQL 774



 Score = 34.3 bits (77), Expect = 0.38
 Identities = 48/270 (17%), Positives = 116/270 (42%), Gaps = 19/270 (7%)

Query: 395  LTSAVSQSKEL-TKTEASKSISRQSEKAHSSGKLQKTVSYPDVSLEEQEKMDLKTSRELC 453
            LTS   +++EL  + +A +    Q E+A S+ +L+ T +   VS       +L  ++ LC
Sbjct: 1315 LTSQAERAEELGQELKAWQEKFFQKEQALSTLQLEHTSTQALVS-------ELLPAKHLC 1367

Query: 454  SRLDASISNNSTSKRKSESATCNLVRDINKVGIGLVAAASSPLLVKDVICEDDKGKIMEE 513
             +L A  +      R+    +      +    +         + ++  + E ++    ++
Sbjct: 1368 QQLQAEQAAAEKRHREELEQSKQAAGGLRAELLRAQRELGELIPLRQKVAEQER--TAQQ 1425

Query: 514  VMRTYLKQQEKLNLILQKKQQLQMEVKMLSSSKSMKELTEEQQNLQKELESLQNEHAQRM 573
            +        E+L+++ +    L  E + L    ++      +Q L+ EL+  + ++ Q  
Sbjct: 1426 LRAEKASYAEQLSMLKKAHGLLAEENRGLGERANLG-----RQFLEVELDQAREKYVQ-- 1478

Query: 574  EEFYVEQKDLEKKLEQIMKQKCTCDSNLEKDKEAEYAGQLAELRQRLDHAEADRQELQDE 633
             E    + D E +L ++ ++  +    LE    A+Y G   ++ +     + +RQ+L  +
Sbjct: 1479 -ELAAVRADAETRLAEVQREAQSTARELEV-MTAKYEGAKVKVLEERQRFQEERQKLTAQ 1536

Query: 634  LRQEREARQKLEMMIKELKLQILKSSKTAK 663
            + Q    +++    ++EL  ++  S + +K
Sbjct: 1537 VEQLEVFQREQTKQVEELSKKLADSDQASK 1566



 Score = 31.2 bits (69), Expect = 3.2
 Identities = 30/139 (21%), Positives = 57/139 (41%), Gaps = 7/139 (5%)

Query: 501  VICEDDKGKIMEEVMRTYLKQQEKLNLILQKKQQLQMEVKMLSSSKSMKELTEEQQNLQK 560
            V+ E +K + +EE +R  L Q E  +      +  +    +    +S++E  E+Q+   +
Sbjct: 1255 VMAESEKSQKLEERLR--LLQAETAS---NSARAAERSSALREEVQSLREEAEKQRVASE 1309

Query: 561  ELESLQNEHAQRMEEFYVEQKDLEKKLEQIMKQKCTCDSNLEKDKEAEYAGQLAELRQRL 620
             L       A+R EE   E K  ++K  Q  K++      LE         +L   +   
Sbjct: 1310 NLRQELTSQAERAEELGQELKAWQEKFFQ--KEQALSTLQLEHTSTQALVSELLPAKHLC 1367

Query: 621  DHAEADRQELQDELRQERE 639
               +A++   +   R+E E
Sbjct: 1368 QQLQAEQAAAEKRHREELE 1386


>gi|222418637 golgi autoantigen, golgin subfamily a-like [Homo
           sapiens]
          Length = 750

 Score = 53.1 bits (126), Expect = 8e-07
 Identities = 49/222 (22%), Positives = 102/222 (45%), Gaps = 23/222 (10%)

Query: 446 LKTSRELCSRLDASISNNSTSKRKSESATCNLVRDINKVGIGLVAAASSPLLVKDVICED 505
           L  S +    L+ ++S  +T K+K++     L ++ + + + L          ++ I + 
Sbjct: 167 LHDSWKFAGELEQALSAVATQKKKADRYIEELTKERDALSLELY---------RNTITD- 216

Query: 506 DKGKIMEEVMRTYLKQQEKLNLILQKKQQLQMEVKMLSSSKSMKELTEEQQNLQKELESL 565
                 EE+     K QEKL L+  +K ++Q+ VK L       +L   QQ LQ E + L
Sbjct: 217 ------EELKEKNAKLQEKLQLVESEKSEIQLNVKELKRKLERAKLLLPQQQLQAEADHL 270

Query: 566 QNE--HAQRMEEFYVEQKDLEKKLEQIMKQKCTCDSNLEKDKEAEYAGQLAELRQRLDHA 623
             E        +  VE+ +L  +L Q  ++K       +++K  E+  ++ E  +++   
Sbjct: 271 GKELQSVSAKLQAQVEENELWNRLNQQQEEKMW----RQEEKIQEWEEKIQEQEEKIREQ 326

Query: 624 EADRQELQDELRQEREAR-QKLEMMIKELKLQILKSSKTAKE 664
           E   +E ++++R++ E   +K E M ++ ++   K  K  ++
Sbjct: 327 EEKIREQEEKMRRQEEMMWEKEEKMRRQEEMMWEKEEKMRRQ 368



 Score = 42.4 bits (98), Expect = 0.001
 Identities = 51/267 (19%), Positives = 128/267 (47%), Gaps = 18/267 (6%)

Query: 399 VSQSKELTKTEASKSISRQSEKAHSSGKLQKTVSYPDVSLEEQEKMDLKTS-RELCSRLD 457
           +++ ++    E  ++     E    + KLQ+ +      L E EK +++ + +EL  +L+
Sbjct: 198 LTKERDALSLELYRNTITDEELKEKNAKLQEKLQ-----LVESEKSEIQLNVKELKRKLE 252

Query: 458 ASISNNSTSKRKSESATCNLVRDINKVGIGLVAAASSPLLVKDVICEDDKG--KIMEEVM 515
            +       +++ ++   +L +++  V   L A      L   +  + ++   +  E++ 
Sbjct: 253 RA--KLLLPQQQLQAEADHLGKELQSVSAKLQAQVEENELWNRLNQQQEEKMWRQEEKIQ 310

Query: 516 RTYLKQQEKLNLILQKKQQLQMEVKMLSSSKSMKELTEEQQNLQKELESLQNEHAQRMEE 575
               K QE+   I +++++++ + + +   + M    EE+   Q+E+   + E  +R EE
Sbjct: 311 EWEEKIQEQEEKIREQEEKIREQEEKMRRQEEMMWEKEEKMRRQEEMMWEKEEKMRRQEE 370

Query: 576 FYVEQKDLEKKLEQIMKQKCTCDSNLEKDKE-AEYAGQLAELRQRLDHAEADRQELQDEL 634
              E+++  ++ E++M +K       EK +E  E   +  ++R++ +  + + +  + E 
Sbjct: 371 MMWEKEEKMRRQEEMMWEK------EEKIRELEEKMHEQEKIREQEEKRQEEEKIREQEK 424

Query: 635 RQEREARQ-KLEMMIKELKLQILKSSK 660
           RQE+EA+  + E  I+E + +I +  K
Sbjct: 425 RQEQEAKMWRQEEKIREQEEKIREQEK 451



 Score = 42.0 bits (97), Expect = 0.002
 Identities = 36/162 (22%), Positives = 82/162 (50%), Gaps = 5/162 (3%)

Query: 504 EDDKGKIMEEVMRTYLKQQEKLNLILQKKQQLQMEVKMLSSSKSMKELTEEQQNLQKELE 563
           +++K +  EE+ R   K  E+  +  ++K+Q Q E KM    + ++E  E+    ++++ 
Sbjct: 536 QEEKIREQEEMWREEEKMHEQEKIWEEEKRQEQ-EDKMWRQEEKIREQEEKVWRQEEKIR 594

Query: 564 SLQNEHAQRMEEFYVEQKDLEKKLEQIMKQKCTCDSNLEKDKEAEYAGQLAELRQRLDHA 623
             + +  ++ E+ + +++ + ++ E+I +Q+       EK +E E   Q  E  +++   
Sbjct: 595 EQEEKRQEQEEKMWKQEEKIREQEEKIQEQEEKIREQEEKIREQEEMTQ--EQEEKMGEQ 652

Query: 624 EADRQELQDELRQEREARQ-KLEMMIKELKLQILKSSKTAKE 664
           E    E Q+E  QE+E    + E  I+E + +I +  +  +E
Sbjct: 653 EEKMCE-QEEKMQEQEETMWRQEEKIREQEKKIREQEEKIRE 693



 Score = 41.6 bits (96), Expect = 0.002
 Identities = 51/261 (19%), Positives = 116/261 (44%), Gaps = 32/261 (12%)

Query: 409 EASKSISRQSEKAHSSGKL--QKTVSYPDVSLEEQEKMDLKTSRELCSRLDASISNNSTS 466
           E  + I    EK H   K+  Q+     +  + EQEK   + ++    R +  I      
Sbjct: 388 EKEEKIRELEEKMHEQEKIREQEEKRQEEEKIREQEKRQEQEAKMW--RQEEKIREQEEK 445

Query: 467 KRKSESATCNLVRDINKVGIGLVAAASSPLLVKDVICEDDKGKIMEEVMRTYLKQQEKLN 526
            R+ E         I++               ++ I E++K +  EE+ R   K  E+  
Sbjct: 446 IREQEKKMWRQEEKIHE---------------QEKIREEEKRQEQEEMWRQEEKIHEQEE 490

Query: 527 LILQKKQQLQMEVKMLSSSKSM----KELTEEQQNLQKELESL--QNEHAQRMEEFYVEQ 580
           +  QK++  + E K+    + +    +++ E+++ ++++ E +  Q E  +  EE + E+
Sbjct: 491 IWRQKEKMHEQEEKIRKQEEKVWRQEEKIREQEEKIREQEEKMWRQEEKIREQEEMWREE 550

Query: 581 KDL---EKKLEQIMKQKCTCDSNLEKDKEAEYAGQLAELRQRLDHAEADRQELQDEL-RQ 636
           + +   EK  E+  +Q+       +++K  E   ++    +++   E  RQE ++++ +Q
Sbjct: 551 EKMHEQEKIWEEEKRQEQEDKMWRQEEKIREQEEKVWRQEEKIREQEEKRQEQEEKMWKQ 610

Query: 637 E---REARQKLEMMIKELKLQ 654
           E   RE  +K++   ++++ Q
Sbjct: 611 EEKIREQEEKIQEQEEKIREQ 631



 Score = 40.8 bits (94), Expect = 0.004
 Identities = 41/150 (27%), Positives = 77/150 (51%), Gaps = 8/150 (5%)

Query: 504 EDDKGKIMEEVMRTYLKQQEKLNLILQKKQQLQMEVKMLSSSKSMKELTEEQQNLQKELE 563
           +++K +  EE +R   +Q+EK+    Q++   + E KM    + M E  EE+   Q+E+ 
Sbjct: 319 QEEKIREQEEKIR---EQEEKMRR--QEEMMWEKEEKMRRQEEMMWE-KEEKMRRQEEMM 372

Query: 564 SLQNEHAQRMEEFYVEQKDLEKKLEQIMKQKCTCDSNLEKDKEAEYAGQLAELRQRLDHA 623
             + E  +R EE   E+++  ++LE+ M ++       EK +E E   +  E RQ    A
Sbjct: 373 WEKEEKMRRQEEMMWEKEEKIRELEEKMHEQEKIREQEEKRQEEEKIRE-QEKRQE-QEA 430

Query: 624 EADRQELQDELRQEREARQKLEMMIKELKL 653
           +  RQE +   ++E+   Q+ +M  +E K+
Sbjct: 431 KMWRQEEKIREQEEKIREQEKKMWRQEEKI 460



 Score = 39.7 bits (91), Expect = 0.009
 Identities = 30/153 (19%), Positives = 79/153 (51%), Gaps = 12/153 (7%)

Query: 504 EDDKGKIMEEVMRTYLKQQEKLN----LILQKKQQLQMEVKMLSSSKSMKELTEEQQNLQ 559
           +++K +  EE M    KQ+EK+      I +++++++ + + +   + M +  EE+   Q
Sbjct: 596 QEEKRQEQEEKM---WKQEEKIREQEEKIQEQEEKIREQEEKIREQEEMTQEQEEKMGEQ 652

Query: 560 KELESLQNEHAQRMEEFYVEQKDLEKKLEQIMKQKCTCDSNLEKDKE--AEYAGQLAELR 617
           +E    Q E  Q  EE    Q++  ++ E+ ++++   +  + + +E   E   ++ E  
Sbjct: 653 EEKMCEQEEKMQEQEETMWRQEEKIREQEKKIREQ---EEKIREQEEMMQEQEEKMWEQE 709

Query: 618 QRLDHAEADRQELQDELRQEREARQKLEMMIKE 650
           +++   E   QE ++++R++ E   + E+ +++
Sbjct: 710 EKMCEQEEKMQEQEEKMRRQEEKMWEQEVRLRQ 742



 Score = 36.2 bits (82), Expect = 0.100
 Identities = 34/161 (21%), Positives = 78/161 (48%), Gaps = 20/161 (12%)

Query: 504 EDDKGKIMEEVMRTYLKQQEKLNLILQKKQQLQMEVKMLSSSKSMKELTEEQQNLQKELE 563
           +++K +  EE+M    +++EK+    Q++   + E KM    + M E  EE+   Q+E+ 
Sbjct: 333 QEEKMRRQEEMM---WEKEEKMRR--QEEMMWEKEEKMRRQEEMMWE-KEEKMRRQEEMM 386

Query: 564 SLQNEHAQRMEEFYVEQKDLEKKLEQIMKQKCTCDSNLEKDKEAEYAGQLAELRQRLDHA 623
             + E  + +EE   EQ+ + ++ E+  +++   +    +++EA+   Q  ++R++ +  
Sbjct: 387 WEKEEKIRELEEKMHEQEKIREQEEKRQEEEKIREQEKRQEQEAKMWRQEEKIREQEEKI 446

Query: 624 EADRQEL--------------QDELRQEREARQKLEMMIKE 650
               +++              ++E RQE+E   + E  I E
Sbjct: 447 REQEKKMWRQEEKIHEQEKIREEEKRQEQEEMWRQEEKIHE 487



 Score = 35.8 bits (81), Expect = 0.13
 Identities = 27/145 (18%), Positives = 72/145 (49%), Gaps = 10/145 (6%)

Query: 512 EEVMRTYLKQQEKLNLILQKKQQLQMEVKMLSSSKSMKELTEEQQNLQKELESLQNEHAQ 571
           E++     K+QE+   + +++++++ + + +   +      EE+   Q+E+   Q E   
Sbjct: 591 EKIREQEEKRQEQEEKMWKQEEKIREQEEKIQEQEEKIREQEEKIREQEEMTQEQEEKMG 650

Query: 572 RMEEFYVEQKDLEKKLEQIMKQKCTCDSNLEKDKEAEYAGQLAELRQRLDHAEADRQELQ 631
             EE   EQ++  ++ E+ M +        +++K  E   ++ E  +++   E   QE +
Sbjct: 651 EQEEKMCEQEEKMQEQEETMWR--------QEEKIREQEKKIREQEEKIREQEEMMQEQE 702

Query: 632 DEL--RQEREARQKLEMMIKELKLQ 654
           +++  ++E+   Q+ +M  +E K++
Sbjct: 703 EKMWEQEEKMCEQEEKMQEQEEKMR 727



 Score = 34.3 bits (77), Expect = 0.38
 Identities = 31/160 (19%), Positives = 74/160 (46%), Gaps = 30/160 (18%)

Query: 512 EEVMRTYLKQQ-EKLNLILQKKQQLQMEVKMLSSSKSMKELTEEQQNLQKELESLQNEHA 570
           +E +R  L+ Q   + ++  +K +LQM +                Q+  K+LE    +  
Sbjct: 118 QEALRRELEAQVHTIRILTCQKTELQMALYY-------------SQHAVKQLEGEARDLI 164

Query: 571 QRMEEFYVEQKDLEKKLEQIMKQKCTCDSNLE---KDKEA-------------EYAGQLA 614
            R+ + +    +LE+ L  +  QK   D  +E   K+++A             E   + A
Sbjct: 165 SRLHDSWKFAGELEQALSAVATQKKKADRYIEELTKERDALSLELYRNTITDEELKEKNA 224

Query: 615 ELRQRLDHAEADRQELQDELRQEREARQKLEMMIKELKLQ 654
           +L+++L   E+++ E+Q  +++ +   ++ ++++ + +LQ
Sbjct: 225 KLQEKLQLVESEKSEIQLNVKELKRKLERAKLLLPQQQLQ 264



 Score = 31.6 bits (70), Expect = 2.5
 Identities = 23/99 (23%), Positives = 52/99 (52%), Gaps = 6/99 (6%)

Query: 499 KDVICEDDKGKIMEEVMRTYLKQQEKLN----LILQKKQQLQMEVKMLSSSKSMKELTEE 554
           ++ +CE ++   M+E   T  +Q+EK+      I +++++++ + +M+   +      EE
Sbjct: 653 EEKMCEQEEK--MQEQEETMWRQEEKIREQEKKIREQEEKIREQEEMMQEQEEKMWEQEE 710

Query: 555 QQNLQKELESLQNEHAQRMEEFYVEQKDLEKKLEQIMKQ 593
           +   Q+E    Q E  +R EE   EQ+   ++ E+ M++
Sbjct: 711 KMCEQEEKMQEQEEKMRRQEEKMWEQEVRLRQQEEKMQE 749


>gi|22538387 A-kinase anchor protein 9 isoform 2 [Homo sapiens]
          Length = 3907

 Score = 53.1 bits (126), Expect = 8e-07
 Identities = 67/324 (20%), Positives = 142/324 (43%), Gaps = 43/324 (13%)

Query: 376  LHPSYYLYMCDKVVAPNVSLTSAVSQSKELTKTEASKSISRQSEKAHSSGKLQK------ 429
            L   Y   + ++V    VS++ A +Q  EL++    K  +  S++AH+  + ++      
Sbjct: 1432 LEKQYQEQLEEEVAKVIVSMSIAFAQQTELSRISGGKENTASSKQAHAVCQQEQHYFNEM 1491

Query: 430  TVSYPDVSLEEQEKMDLK-------TSRELCSRLDASISNNSTSKRKSESATCNLVRDIN 482
             +S   +  +  E +D+K        S+EL       + +NS      ES  C L     
Sbjct: 1492 KLSQDQIGFQTFETVDVKFKEEFKPLSKELGEHGKEILLSNSDPHDIPESKDCVLTISEE 1551

Query: 483  KVGIGLVAAASSPLLVKDVICEDDKGKIMEEVMRTYLKQQEKLNL---ILQKKQQLQMEV 539
                  + +     +V+  I ++     M+   +  L +++  ++   ++++ Q+ Q   
Sbjct: 1552 ------MFSKDKTFIVRQSIHDEISVSSMDASRQLMLNEEQLEDMRQELVRQYQEHQQAT 1605

Query: 540  KMLSSS--KSMKELTEEQQNLQKELESLQNEHAQR-----------MEEFYVEQKDLEKK 586
            ++L  +  + M+   E+Q+ LQ+E++ L  + AQR            E   +E+ +  K+
Sbjct: 1606 ELLRQAHMRQMERQREDQEQLQEEIKRLNRQLAQRSSIDNENLVSERERVLLEELEALKQ 1665

Query: 587  LEQIMKQKCTCD---SNLEKDKEAEYAGQLAELRQRLDHAEADR--QELQDE-LRQEREA 640
            L    ++K  C+   S+ +     E  G++ E  Q     E DR  +++  E L  ER A
Sbjct: 1666 LSLAGREKLCCELRNSSTQTQNGNENQGEVEE--QTFKEKELDRKPEDVPPEILSNERYA 1723

Query: 641  RQKLEMMIKELKLQILKSSKTAKE 664
             QK    + ++ L+++K++   +E
Sbjct: 1724 LQKANNRLLKILLEVVKTTAAVEE 1747



 Score = 47.8 bits (112), Expect = 3e-05
 Identities = 38/147 (25%), Positives = 75/147 (51%), Gaps = 7/147 (4%)

Query: 512  EEVMRTYLKQQEKLNLILQKKQQL--QMEVKMLSSSKSMKELTEEQQNLQKELESL-QNE 568
            E V+  Y  ++      +Q+K  +  ++E ++L +S  ++EL  EQQ +Q+E E L + +
Sbjct: 1921 EGVIDGYADEKTLFERQIQEKTDIIDRLEQELLCASNRLQELEAEQQQIQEERELLSRQK 1980

Query: 569  HAQRMEEFYVEQKDLEKKLEQIMKQKCTCDSNLEK---DKEAEYAGQLAELRQRLDHAEA 625
             A + E   VEQ+ L ++ E++MK+K       EK   D + +      ++ +++     
Sbjct: 1981 EAMKAEAGPVEQQ-LLQETEKLMKEKLEVQCQAEKVRDDLQKQVKALEIDVEEQVSRFIE 2039

Query: 626  DRQELQDELRQEREARQKLEMMIKELK 652
              QE   EL   R+  Q LE  +++++
Sbjct: 2040 LEQEKNTELMDLRQQNQALEKQLEKMR 2066



 Score = 46.6 bits (109), Expect = 7e-05
 Identities = 64/310 (20%), Positives = 139/310 (44%), Gaps = 45/310 (14%)

Query: 393  VSLTSAVSQSKELTKTEASKSISRQSEKAHSSGKLQKTVS---YPDVSLEEQEKMDLKTS 449
            +S TS+  +  ++T+TE  +   RQ ++A  S K Q+ +    + +    EQ  ++L  +
Sbjct: 1861 ISETSSQLEHAKVTQTELMRESFRQKQEATESLKCQEELRERLHEESRAREQLAVELSKA 1920

Query: 450  R---------------------ELCSRLDASI--SNNSTSKRKSESATCNLVRDINKVGI 486
                                  ++  RL+  +  ++N   + ++E       R++     
Sbjct: 1921 EGVIDGYADEKTLFERQIQEKTDIIDRLEQELLCASNRLQELEAEQQQIQEERELLSRQK 1980

Query: 487  GLVAAASSPLLVKDVICEDDKGKIMEEVMRTYLKQQEKLNLILQKK-QQLQMEVKMLSS- 544
              + A + P  V+  + ++ + K+M+E +     Q EK+   LQK+ + L+++V+   S 
Sbjct: 1981 EAMKAEAGP--VEQQLLQETE-KLMKEKLEVQC-QAEKVRDDLQKQVKALEIDVEEQVSR 2036

Query: 545  --------SKSMKELTEEQQNLQKELES----LQNEHAQRMEEFYVEQKDLEKKLEQIMK 592
                    +  + +L ++ Q L+K+LE     L  +   R  E  V Q++++K  +Q+  
Sbjct: 2037 FIELEQEKNTELMDLRQQNQALEKQLEKMRKFLDEQAIDREHERDVFQQEIQKLEQQLKV 2096

Query: 593  QKCTCDSNLEKDKEAEY-AGQLAELRQRLDHAEADRQELQDELRQEREARQKLEMMIKEL 651
                   +  + +E E  A  L E   +       +++LQ ++++  E  +KLE  ++EL
Sbjct: 2097 VPRFQPISEHQTREVEQLANHLKEKTDKCSELLLSKEQLQRDIQERNEEIEKLEFRVREL 2156

Query: 652  KLQILKSSKT 661
            +  +L S+ T
Sbjct: 2157 EQALLVSADT 2166



 Score = 43.1 bits (100), Expect = 8e-04
 Identities = 74/392 (18%), Positives = 164/392 (41%), Gaps = 61/392 (15%)

Query: 318 TPEEKKLKIILEEMKEKFSMRSGKRNQSKTDAPSGMELQSWYPVIKQEGDHVSQTH---- 373
           T + +KL+I  ++++   ++R+   + +  D     +    +    +E DH+ + +    
Sbjct: 232 TEQSQKLQIQFQQLQASETLRNSTHSSTAADLLQAKQQILTHQQQLEEQDHLLEDYQKKK 291

Query: 374 -------SFLHPSYYLYMCDKVVAPNVSLTSAVSQSKELTKTEASKSISRQSEKAHSSGK 426
                  SFL     +Y  ++      S    + Q KE    E +  I  + +K     +
Sbjct: 292 EDFTMQISFLQEKIKVYEMEQDKKVENSNKEEI-QEKETIIEELNTKIIEEEKKTL---E 347

Query: 427 LQKTVSYPDVSLEEQEKMDLKTSRELCSRLDASISNNSTSKRKSESATCNLVRDINKVGI 486
           L+  ++  D  L E ++  ++ ++E+   +   ++N+   +R+S      L+  + ++  
Sbjct: 348 LKDKLTTADKLLGELQEQIVQKNQEI-KNMKLELTNSKQKERQSSEEIKQLMGTVEEL-- 404

Query: 487 GLVAAASSPLLVKDVICEDDKGKIMEEVMRTYLKQ-QEKLN-----LILQKKQQL----- 535
                       KD   E D  + ME+  +  L+Q + +L+      I+Q KQ+L     
Sbjct: 405 -------QKRNHKDSQFETDIVQRMEQETQRKLEQLRAELDEMYGQQIVQMKQELIRQHM 457

Query: 536 -QMEVKMLSSSKSMKELTEEQQNLQKELESLQ------NEHAQRMEEFYVEQKDLEKKLE 588
            QME         M+       N+    + ++      NE   ++++   +++ L+++L 
Sbjct: 458 AQMEEMKTRHKGEMENALRSYSNITVNEDQIKLMNVAINELNIKLQDTNSQKEKLKEELG 517

Query: 589 QIMKQKCTCDSNLE--------KDKEAEYAGQ-LAELRQRLDHAEADRQELQD------- 632
            I+++KC     LE          ++ + A Q +AE   +L+ A      ++D       
Sbjct: 518 LILEEKCALQRQLEDLVEELSFSREQIQRARQTIAEQESKLNEAHKSLSTVEDLKAEIVS 577

Query: 633 --ELRQEREARQKLEMMIKELKLQILKSSKTA 662
             E R+E E + + E+   ++KL++L+  K A
Sbjct: 578 ASESRKELELKHEAEVTNYKIKLEMLEKEKNA 609



 Score = 39.3 bits (90), Expect = 0.012
 Identities = 43/153 (28%), Positives = 74/153 (48%), Gaps = 22/153 (14%)

Query: 521 QQEKLNLILQKKQQLQMEVKMLS-------SSKSMKELTEEQQNLQKELESLQNEHAQR- 572
           Q EK NLI  K+ QL +E+  L        +SKS +E+T +   LQKE+E L+ E  ++ 
Sbjct: 682 QFEKDNLIT-KQNQLILEISKLKDLQQSLVNSKS-EEMTLQINELQKEIEILRQEEKEKG 739

Query: 573 -MEEFYVEQKDLEKKLEQIMKQKCTCDSNLEKDKEAEYAGQLAELRQRLDHAEADRQELQ 631
            +E+   E ++L+ K E + KQ         K+KE +   + A+L       + +++ L+
Sbjct: 740 TLEQ---EVQELQLKTELLEKQM--------KEKENDLQEKFAQLEAENSILKDEKKTLE 788

Query: 632 DELRQEREARQKLEMMIKELKLQILKSSKTAKE 664
           D L+      Q+  ++  +      K S   KE
Sbjct: 789 DMLKIHTPVSQEERLIFLDSIKSKSKDSVWEKE 821



 Score = 39.3 bits (90), Expect = 0.012
 Identities = 68/329 (20%), Positives = 140/329 (42%), Gaps = 38/329 (11%)

Query: 320  EEKKLKIILEEMKEKFSMRSGKRNQSKTD-APSGMELQSWYPVIKQEGDHVSQTHSFLHP 378
            E   +K    E++E+ S       + K++ A + +EL++    +K +  H+ +  +F   
Sbjct: 3139 ELSSMKDRATELQEQLSSEKMVVAELKSELAQTKLELET---TLKAQHKHLKELEAFR-- 3193

Query: 379  SYYLYMCDKVVAPNVSLTSAVSQSKELTKTEASKSISRQSEKAHSSGKLQKT-VSYPDVS 437
               L + DK     V L +    S++    E   ++ ++  K   S +  K  +     S
Sbjct: 3194 ---LEVKDKT--DEVHLLNDTLASEQKKSRELQWALEKEKAKLGRSEERDKEELEDLKFS 3248

Query: 438  LEEQEKMDLKTSRELCSRLDASISNNSTSKRKSESATCNLVRDINKVGIGLVAAASSPLL 497
            LE Q++ +L+ +  L       + N S  K +S+     ++ D        ++      L
Sbjct: 3249 LESQKQRNLQLN--LLLEQQKQLLNESQQKIESQ----RMLYDAQ------LSEEQGRNL 3296

Query: 498  VKDVICEDDKGKIMEEVMRTYLKQQEKLNLILQKKQQLQMEVKMLSSSKSMKELTEEQQN 557
               V+ E +K +I E  M + L ++ +L+  LQ           L S   +KEL      
Sbjct: 3297 ELQVLLESEKVRIRE--MSSTLDRERELHAQLQSSDGTGQSRPPLPSEDLLKEL------ 3348

Query: 558  LQKELESLQNEHAQRMEEFYVEQKDLEKKLEQIMKQKCTCDSNLEKDKEAEYAGQLAELR 617
             QK+LE   +   + + E    + D  +  +Q+ K +      L+ ++EA   GQ     
Sbjct: 3349 -QKQLEEKHSRIVELLNETEKYKLDSLQTRQQMEKDRQVHRKTLQTEQEANTEGQ----- 3402

Query: 618  QRLDHAEADRQELQDELRQEREARQKLEM 646
            +++   ++  ++LQ +L ++R+   KL++
Sbjct: 3403 KKMHELQSKVEDLQRQLEEKRQQVYKLDL 3431



 Score = 38.5 bits (88), Expect = 0.020
 Identities = 42/169 (24%), Positives = 84/169 (49%), Gaps = 18/169 (10%)

Query: 504 EDDKGKIMEEVMRTYLK-------QQEKLNLILQKKQQLQMEVKML-SSSKSMKELTEEQ 555
           E +KG + +EV    LK        +EK N + +K  QL+ E  +L    K+++++ +  
Sbjct: 735 EKEKGTLEQEVQELQLKTELLEKQMKEKENDLQEKFAQLEAENSILKDEKKTLEDMLKIH 794

Query: 556 QNLQKELESLQNEHAQRMEEFYVEQKDLEKKLE--QIMKQKC-TCDSNLEKDKEA-EYAG 611
             + +E   +  +  +   +  V +K++E  +E  + +KQ+C   +  +EK +    +A 
Sbjct: 795 TPVSQEERLIFLDSIKSKSKDSVWEKEIEILIEENEDLKQQCIQLNEEIEKQRNTFSFAE 854

Query: 612 QLAELR-QRLDHAEADRQELQDEL-----RQEREARQKLEMMIKELKLQ 654
           +  E+  Q L    A   +++D+L     +QE E + KL+ + +EL LQ
Sbjct: 855 KNFEVNYQELQEEYACLLKVKDDLEDSKNKQELEYKSKLKALNEELHLQ 903



 Score = 38.1 bits (87), Expect = 0.026
 Identities = 36/175 (20%), Positives = 82/175 (46%), Gaps = 22/175 (12%)

Query: 512 EEVMRTYLK---QQEKLNLILQKKQQ----------------LQMEVKMLSSSKSMKELT 552
           +E MR +L+   Q +KL +  Q+ Q                 LQ + ++L+  + ++E  
Sbjct: 222 DETMREFLELTEQSQKLQIQFQQLQASETLRNSTHSSTAADLLQAKQQILTHQQQLEEQD 281

Query: 553 EEQQNLQKELESLQNEHAQRMEEFYVEQKDLEKKLEQIMKQKCTCDSNLEKD---KEAEY 609
              ++ QK+ E    + +   E+  V + + +KK+E   K++      + ++   K  E 
Sbjct: 282 HLLEDYQKKKEDFTMQISFLQEKIKVYEMEQDKKVENSNKEEIQEKETIIEELNTKIIEE 341

Query: 610 AGQLAELRQRLDHAEADRQELQDELRQEREARQKLEMMIKELKLQILKSSKTAKE 664
             +  EL+ +L  A+    ELQ+++ Q+ +  + +++ +   K +  +SS+  K+
Sbjct: 342 EKKTLELKDKLTTADKLLGELQEQIVQKNQEIKNMKLELTNSKQKERQSSEEIKQ 396



 Score = 36.2 bits (82), Expect = 0.100
 Identities = 39/173 (22%), Positives = 79/173 (45%), Gaps = 36/173 (20%)

Query: 504  EDDKGKIMEEVMRTYLKQQEKLNLILQ------KKQQLQMEVKMLSSSKSMKELTEEQQN 557
            E +  K  +E++   ++Q++   L +Q      K +  +++ ++ S    + EL  E   
Sbjct: 3111 EQESEKPSQELLEYNIQQKQSQMLEMQVELSSMKDRATELQEQLSSEKMVVAELKSELAQ 3170

Query: 558  LQKELESL---QNEHAQRMEEFYVEQKDL--------------EKKLEQIM----KQKCT 596
             + ELE+    Q++H + +E F +E KD               +KK  ++     K+K  
Sbjct: 3171 TKLELETTLKAQHKHLKELEAFRLEVKDKTDEVHLLNDTLASEQKKSRELQWALEKEKAK 3230

Query: 597  CDSNLEKDKEAEYAGQLAELRQRLDHAEADRQELQDELRQER----EARQKLE 645
               + E+DKE     +L +L+  L+  +    +L   L Q++    E++QK+E
Sbjct: 3231 LGRSEERDKE-----ELEDLKFSLESQKQRNLQLNLLLEQQKQLLNESQQKIE 3278



 Score = 35.4 bits (80), Expect = 0.17
 Identities = 57/284 (20%), Positives = 131/284 (46%), Gaps = 30/284 (10%)

Query: 393  VSLTSAVSQSKELTKTEASKSI---SRQSEKAHSSGKLQKTVSYPDVSLEEQE--KMDLK 447
            V L+S   ++ EL +  +S+ +     +SE A +  +L+ T+      L+E E  ++++K
Sbjct: 3138 VELSSMKDRATELQEQLSSEKMVVAELKSELAQTKLELETTLKAQHKHLKELEAFRLEVK 3197

Query: 448  TSRELCSRLDASISNNSTSKRKSESATCNLVRDINKVGIG-------------LVAAASS 494
               +    L+ ++++     R+ + A   L ++  K+G                + +   
Sbjct: 3198 DKTDEVHLLNDTLASEQKKSRELQWA---LEKEKAKLGRSEERDKEELEDLKFSLESQKQ 3254

Query: 495  PLLVKDVICEDDKGKIMEEVMRTYLKQQEKLNLILQKKQQLQMEVKMLSSSKSMKELTEE 554
              L  +++ E  K +++ E  +    Q+   +  L ++Q   +E+++L  S+ ++ + E 
Sbjct: 3255 RNLQLNLLLEQQK-QLLNESQQKIESQRMLYDAQLSEEQGRNLELQVLLESEKVR-IREM 3312

Query: 555  QQNLQKELE---SLQNEHAQRMEEFYVEQKDLEKKLEQIMKQKCTCDSNLEKDKEAEYAG 611
               L +E E    LQ+          +  +DL K+L++ +++K +    L  + E +Y  
Sbjct: 3313 SSTLDRERELHAQLQSSDGTGQSRPPLPSEDLLKELQKQLEEKHSRIVELLNETE-KYKL 3371

Query: 612  QLAELRQRLDHAEADRQELQDELRQEREARQKLEMMIKELKLQI 655
               + RQ++   E DRQ  +  L+ E+EA  + +  + EL+ ++
Sbjct: 3372 DSLQTRQQM---EKDRQVHRKTLQTEQEANTEGQKKMHELQSKV 3412



 Score = 34.3 bits (77), Expect = 0.38
 Identities = 32/152 (21%), Positives = 69/152 (45%), Gaps = 11/152 (7%)

Query: 522  QEKLNLILQKKQQLQ----MEVKMLSSSKSMKELTEEQQNLQKELESLQNEHAQRMEEFY 577
            ++ L  I +   QL+     + +++  S   K+   E    Q+EL    +E ++  E+  
Sbjct: 1855 EKLLEAISETSSQLEHAKVTQTELMRESFRQKQEATESLKCQEELRERLHEESRAREQLA 1914

Query: 578  VEQKDLEKKLEQIMKQKCTCDSNLEKDKEA--EYAGQLAELRQRLDHAEADRQELQDE-- 633
            VE    E  ++    +K   +  +++  +       +L     RL   EA++Q++Q+E  
Sbjct: 1915 VELSKAEGVIDGYADEKTLFERQIQEKTDIIDRLEQELLCASNRLQELEAEQQQIQEERE 1974

Query: 634  -LRQEREARQKLEMMIKELKLQILKSSKTAKE 664
             L +++EA +     +++  LQ  ++ K  KE
Sbjct: 1975 LLSRQKEAMKAEAGPVEQQLLQ--ETEKLMKE 2004



 Score = 33.5 bits (75), Expect = 0.65
 Identities = 34/151 (22%), Positives = 72/151 (47%), Gaps = 11/151 (7%)

Query: 517  TYLKQQEKLNL-ILQKKQQLQMEVKMLSSSKSMKELTEEQQNLQKELESLQNEHAQRMEE 575
            T+ K +++ +   ++ K +L +EV++ +   ++    +E  NL+++LE  + E   + EE
Sbjct: 2166 TFQKVEDRKHFGAVEAKPELSLEVQLQAERDAIDRKEKEITNLEEQLEQFREELENKNEE 2225

Query: 576  FYVEQKDLEKKLEQIMKQKCTCDSNLEKDKEAEYAGQLAELRQRLDHAEADRQELQDE-- 633
                 + L  +LE   K+  T    LE++ +  +   + +L   L   E+D    QD+  
Sbjct: 2226 V----QQLHMQLEIQKKESTTRLQELEQENKL-FKDDMEKL--GLAIKESDAMSTQDQHV 2278

Query: 634  -LRQEREARQKLEMMIKELKLQILKSSKTAK 663
               +  +  Q+ E+ I +L  Q+ K  +  K
Sbjct: 2279 LFGKFAQIIQEKEVEIDQLNEQVTKLQQQLK 2309



 Score = 29.6 bits (65), Expect = 9.3
 Identities = 37/141 (26%), Positives = 65/141 (46%), Gaps = 27/141 (19%)

Query: 520 KQQEKLNLILQKKQQLQMEVKMLSS--SKSMKELTEEQQNLQKELESLQNEHAQ--RMEE 575
           K +E+L LIL++K  LQ +++ L    S S +++   +Q + ++   L   H     +E+
Sbjct: 511 KLKEELGLILEEKCALQRQLEDLVEELSFSREQIQRARQTIAEQESKLNEAHKSLSTVED 570

Query: 576 FYVE-------QKDLEKK-----------LEQIMKQKCTCDSNLEKDKEAEYAGQLAELR 617
              E       +K+LE K           LE + K+K      + + +EAE    L  LR
Sbjct: 571 LKAEIVSASESRKELELKHEAEVTNYKIKLEMLEKEKNAVLDRMAESQEAE----LERLR 626

Query: 618 -QRLDHAEADRQELQDELRQE 637
            Q L   E +  +L+++L  E
Sbjct: 627 TQLLFSHEEELSKLKEDLEIE 647



 Score = 29.6 bits (65), Expect = 9.3
 Identities = 19/74 (25%), Positives = 36/74 (48%)

Query: 520  KQQEKLNLILQKKQQLQMEVKMLSSSKSMKELTEEQQNLQKELESLQNEHAQRMEEFYVE 579
            +Q + + L   ++   + E + LS    M  L +   N + +L SLQ+    ++EE   E
Sbjct: 1283 QQTDGMKLEFGEENLPKEETEFLSIHSQMTNLEDIDVNHKSKLSSLQDLEKTKLEEQVQE 1342

Query: 580  QKDLEKKLEQIMKQ 593
             + L   L+Q +K+
Sbjct: 1343 LESLISSLQQQLKE 1356


>gi|22538393 A-kinase anchor protein 9 isoform 3 [Homo sapiens]
          Length = 3899

 Score = 53.1 bits (126), Expect = 8e-07
 Identities = 67/324 (20%), Positives = 142/324 (43%), Gaps = 43/324 (13%)

Query: 376  LHPSYYLYMCDKVVAPNVSLTSAVSQSKELTKTEASKSISRQSEKAHSSGKLQK------ 429
            L   Y   + ++V    VS++ A +Q  EL++    K  +  S++AH+  + ++      
Sbjct: 1432 LEKQYQEQLEEEVAKVIVSMSIAFAQQTELSRISGGKENTASSKQAHAVCQQEQHYFNEM 1491

Query: 430  TVSYPDVSLEEQEKMDLK-------TSRELCSRLDASISNNSTSKRKSESATCNLVRDIN 482
             +S   +  +  E +D+K        S+EL       + +NS      ES  C L     
Sbjct: 1492 KLSQDQIGFQTFETVDVKFKEEFKPLSKELGEHGKEILLSNSDPHDIPESKDCVLTISEE 1551

Query: 483  KVGIGLVAAASSPLLVKDVICEDDKGKIMEEVMRTYLKQQEKLNL---ILQKKQQLQMEV 539
                  + +     +V+  I ++     M+   +  L +++  ++   ++++ Q+ Q   
Sbjct: 1552 ------MFSKDKTFIVRQSIHDEISVSSMDASRQLMLNEEQLEDMRQELVRQYQEHQQAT 1605

Query: 540  KMLSSS--KSMKELTEEQQNLQKELESLQNEHAQR-----------MEEFYVEQKDLEKK 586
            ++L  +  + M+   E+Q+ LQ+E++ L  + AQR            E   +E+ +  K+
Sbjct: 1606 ELLRQAHMRQMERQREDQEQLQEEIKRLNRQLAQRSSIDNENLVSERERVLLEELEALKQ 1665

Query: 587  LEQIMKQKCTCD---SNLEKDKEAEYAGQLAELRQRLDHAEADR--QELQDE-LRQEREA 640
            L    ++K  C+   S+ +     E  G++ E  Q     E DR  +++  E L  ER A
Sbjct: 1666 LSLAGREKLCCELRNSSTQTQNGNENQGEVEE--QTFKEKELDRKPEDVPPEILSNERYA 1723

Query: 641  RQKLEMMIKELKLQILKSSKTAKE 664
             QK    + ++ L+++K++   +E
Sbjct: 1724 LQKANNRLLKILLEVVKTTAAVEE 1747



 Score = 47.8 bits (112), Expect = 3e-05
 Identities = 38/147 (25%), Positives = 75/147 (51%), Gaps = 7/147 (4%)

Query: 512  EEVMRTYLKQQEKLNLILQKKQQL--QMEVKMLSSSKSMKELTEEQQNLQKELESL-QNE 568
            E V+  Y  ++      +Q+K  +  ++E ++L +S  ++EL  EQQ +Q+E E L + +
Sbjct: 1921 EGVIDGYADEKTLFERQIQEKTDIIDRLEQELLCASNRLQELEAEQQQIQEERELLSRQK 1980

Query: 569  HAQRMEEFYVEQKDLEKKLEQIMKQKCTCDSNLEK---DKEAEYAGQLAELRQRLDHAEA 625
             A + E   VEQ+ L ++ E++MK+K       EK   D + +      ++ +++     
Sbjct: 1981 EAMKAEAGPVEQQ-LLQETEKLMKEKLEVQCQAEKVRDDLQKQVKALEIDVEEQVSRFIE 2039

Query: 626  DRQELQDELRQEREARQKLEMMIKELK 652
              QE   EL   R+  Q LE  +++++
Sbjct: 2040 LEQEKNTELMDLRQQNQALEKQLEKMR 2066



 Score = 43.9 bits (102), Expect = 5e-04
 Identities = 62/305 (20%), Positives = 136/305 (44%), Gaps = 45/305 (14%)

Query: 393  VSLTSAVSQSKELTKTEASKSISRQSEKAHSSGKLQKTVS---YPDVSLEEQEKMDLKTS 449
            +S TS+  +  ++T+TE  +   RQ ++A  S K Q+ +    + +    EQ  ++L  +
Sbjct: 1861 ISETSSQLEHAKVTQTELMRESFRQKQEATESLKCQEELRERLHEESRAREQLAVELSKA 1920

Query: 450  R---------------------ELCSRLDASI--SNNSTSKRKSESATCNLVRDINKVGI 486
                                  ++  RL+  +  ++N   + ++E       R++     
Sbjct: 1921 EGVIDGYADEKTLFERQIQEKTDIIDRLEQELLCASNRLQELEAEQQQIQEERELLSRQK 1980

Query: 487  GLVAAASSPLLVKDVICEDDKGKIMEEVMRTYLKQQEKLNLILQKK-QQLQMEVKMLSS- 544
              + A + P  V+  + ++ + K+M+E +     Q EK+   LQK+ + L+++V+   S 
Sbjct: 1981 EAMKAEAGP--VEQQLLQETE-KLMKEKLEVQC-QAEKVRDDLQKQVKALEIDVEEQVSR 2036

Query: 545  --------SKSMKELTEEQQNLQKELES----LQNEHAQRMEEFYVEQKDLEKKLEQIMK 592
                    +  + +L ++ Q L+K+LE     L  +   R  E  V Q++++K  +Q+  
Sbjct: 2037 FIELEQEKNTELMDLRQQNQALEKQLEKMRKFLDEQAIDREHERDVFQQEIQKLEQQLKV 2096

Query: 593  QKCTCDSNLEKDKEAEY-AGQLAELRQRLDHAEADRQELQDELRQEREARQKLEMMIKEL 651
                   +  + +E E  A  L E   +       +++LQ ++++  E  +KLE  ++EL
Sbjct: 2097 VPRFQPISEHQTREVEQLANHLKEKTDKCSELLLSKEQLQRDIQERNEEIEKLEFRVREL 2156

Query: 652  KLQIL 656
            +  +L
Sbjct: 2157 EQALL 2161



 Score = 43.1 bits (100), Expect = 8e-04
 Identities = 74/392 (18%), Positives = 164/392 (41%), Gaps = 61/392 (15%)

Query: 318 TPEEKKLKIILEEMKEKFSMRSGKRNQSKTDAPSGMELQSWYPVIKQEGDHVSQTH---- 373
           T + +KL+I  ++++   ++R+   + +  D     +    +    +E DH+ + +    
Sbjct: 232 TEQSQKLQIQFQQLQASETLRNSTHSSTAADLLQAKQQILTHQQQLEEQDHLLEDYQKKK 291

Query: 374 -------SFLHPSYYLYMCDKVVAPNVSLTSAVSQSKELTKTEASKSISRQSEKAHSSGK 426
                  SFL     +Y  ++      S    + Q KE    E +  I  + +K     +
Sbjct: 292 EDFTMQISFLQEKIKVYEMEQDKKVENSNKEEI-QEKETIIEELNTKIIEEEKKTL---E 347

Query: 427 LQKTVSYPDVSLEEQEKMDLKTSRELCSRLDASISNNSTSKRKSESATCNLVRDINKVGI 486
           L+  ++  D  L E ++  ++ ++E+   +   ++N+   +R+S      L+  + ++  
Sbjct: 348 LKDKLTTADKLLGELQEQIVQKNQEI-KNMKLELTNSKQKERQSSEEIKQLMGTVEEL-- 404

Query: 487 GLVAAASSPLLVKDVICEDDKGKIMEEVMRTYLKQ-QEKLN-----LILQKKQQL----- 535
                       KD   E D  + ME+  +  L+Q + +L+      I+Q KQ+L     
Sbjct: 405 -------QKRNHKDSQFETDIVQRMEQETQRKLEQLRAELDEMYGQQIVQMKQELIRQHM 457

Query: 536 -QMEVKMLSSSKSMKELTEEQQNLQKELESLQ------NEHAQRMEEFYVEQKDLEKKLE 588
            QME         M+       N+    + ++      NE   ++++   +++ L+++L 
Sbjct: 458 AQMEEMKTRHKGEMENALRSYSNITVNEDQIKLMNVAINELNIKLQDTNSQKEKLKEELG 517

Query: 589 QIMKQKCTCDSNLE--------KDKEAEYAGQ-LAELRQRLDHAEADRQELQD------- 632
            I+++KC     LE          ++ + A Q +AE   +L+ A      ++D       
Sbjct: 518 LILEEKCALQRQLEDLVEELSFSREQIQRARQTIAEQESKLNEAHKSLSTVEDLKAEIVS 577

Query: 633 --ELRQEREARQKLEMMIKELKLQILKSSKTA 662
             E R+E E + + E+   ++KL++L+  K A
Sbjct: 578 ASESRKELELKHEAEVTNYKIKLEMLEKEKNA 609



 Score = 39.3 bits (90), Expect = 0.012
 Identities = 43/153 (28%), Positives = 74/153 (48%), Gaps = 22/153 (14%)

Query: 521 QQEKLNLILQKKQQLQMEVKMLS-------SSKSMKELTEEQQNLQKELESLQNEHAQR- 572
           Q EK NLI  K+ QL +E+  L        +SKS +E+T +   LQKE+E L+ E  ++ 
Sbjct: 682 QFEKDNLIT-KQNQLILEISKLKDLQQSLVNSKS-EEMTLQINELQKEIEILRQEEKEKG 739

Query: 573 -MEEFYVEQKDLEKKLEQIMKQKCTCDSNLEKDKEAEYAGQLAELRQRLDHAEADRQELQ 631
            +E+   E ++L+ K E + KQ         K+KE +   + A+L       + +++ L+
Sbjct: 740 TLEQ---EVQELQLKTELLEKQM--------KEKENDLQEKFAQLEAENSILKDEKKTLE 788

Query: 632 DELRQEREARQKLEMMIKELKLQILKSSKTAKE 664
           D L+      Q+  ++  +      K S   KE
Sbjct: 789 DMLKIHTPVSQEERLIFLDSIKSKSKDSVWEKE 821



 Score = 39.3 bits (90), Expect = 0.012
 Identities = 68/329 (20%), Positives = 140/329 (42%), Gaps = 38/329 (11%)

Query: 320  EEKKLKIILEEMKEKFSMRSGKRNQSKTD-APSGMELQSWYPVIKQEGDHVSQTHSFLHP 378
            E   +K    E++E+ S       + K++ A + +EL++    +K +  H+ +  +F   
Sbjct: 3131 ELSSMKDRATELQEQLSSEKMVVAELKSELAQTKLELET---TLKAQHKHLKELEAFR-- 3185

Query: 379  SYYLYMCDKVVAPNVSLTSAVSQSKELTKTEASKSISRQSEKAHSSGKLQKT-VSYPDVS 437
               L + DK     V L +    S++    E   ++ ++  K   S +  K  +     S
Sbjct: 3186 ---LEVKDKT--DEVHLLNDTLASEQKKSRELQWALEKEKAKLGRSEERDKEELEDLKFS 3240

Query: 438  LEEQEKMDLKTSRELCSRLDASISNNSTSKRKSESATCNLVRDINKVGIGLVAAASSPLL 497
            LE Q++ +L+ +  L       + N S  K +S+     ++ D        ++      L
Sbjct: 3241 LESQKQRNLQLN--LLLEQQKQLLNESQQKIESQ----RMLYDAQ------LSEEQGRNL 3288

Query: 498  VKDVICEDDKGKIMEEVMRTYLKQQEKLNLILQKKQQLQMEVKMLSSSKSMKELTEEQQN 557
               V+ E +K +I E  M + L ++ +L+  LQ           L S   +KEL      
Sbjct: 3289 ELQVLLESEKVRIRE--MSSTLDRERELHAQLQSSDGTGQSRPPLPSEDLLKEL------ 3340

Query: 558  LQKELESLQNEHAQRMEEFYVEQKDLEKKLEQIMKQKCTCDSNLEKDKEAEYAGQLAELR 617
             QK+LE   +   + + E    + D  +  +Q+ K +      L+ ++EA   GQ     
Sbjct: 3341 -QKQLEEKHSRIVELLNETEKYKLDSLQTRQQMEKDRQVHRKTLQTEQEANTEGQ----- 3394

Query: 618  QRLDHAEADRQELQDELRQEREARQKLEM 646
            +++   ++  ++LQ +L ++R+   KL++
Sbjct: 3395 KKMHELQSKVEDLQRQLEEKRQQVYKLDL 3423



 Score = 38.5 bits (88), Expect = 0.020
 Identities = 42/169 (24%), Positives = 84/169 (49%), Gaps = 18/169 (10%)

Query: 504 EDDKGKIMEEVMRTYLK-------QQEKLNLILQKKQQLQMEVKML-SSSKSMKELTEEQ 555
           E +KG + +EV    LK        +EK N + +K  QL+ E  +L    K+++++ +  
Sbjct: 735 EKEKGTLEQEVQELQLKTELLEKQMKEKENDLQEKFAQLEAENSILKDEKKTLEDMLKIH 794

Query: 556 QNLQKELESLQNEHAQRMEEFYVEQKDLEKKLE--QIMKQKC-TCDSNLEKDKEA-EYAG 611
             + +E   +  +  +   +  V +K++E  +E  + +KQ+C   +  +EK +    +A 
Sbjct: 795 TPVSQEERLIFLDSIKSKSKDSVWEKEIEILIEENEDLKQQCIQLNEEIEKQRNTFSFAE 854

Query: 612 QLAELR-QRLDHAEADRQELQDEL-----RQEREARQKLEMMIKELKLQ 654
           +  E+  Q L    A   +++D+L     +QE E + KL+ + +EL LQ
Sbjct: 855 KNFEVNYQELQEEYACLLKVKDDLEDSKNKQELEYKSKLKALNEELHLQ 903



 Score = 38.1 bits (87), Expect = 0.026
 Identities = 36/175 (20%), Positives = 82/175 (46%), Gaps = 22/175 (12%)

Query: 512 EEVMRTYLK---QQEKLNLILQKKQQ----------------LQMEVKMLSSSKSMKELT 552
           +E MR +L+   Q +KL +  Q+ Q                 LQ + ++L+  + ++E  
Sbjct: 222 DETMREFLELTEQSQKLQIQFQQLQASETLRNSTHSSTAADLLQAKQQILTHQQQLEEQD 281

Query: 553 EEQQNLQKELESLQNEHAQRMEEFYVEQKDLEKKLEQIMKQKCTCDSNLEKD---KEAEY 609
              ++ QK+ E    + +   E+  V + + +KK+E   K++      + ++   K  E 
Sbjct: 282 HLLEDYQKKKEDFTMQISFLQEKIKVYEMEQDKKVENSNKEEIQEKETIIEELNTKIIEE 341

Query: 610 AGQLAELRQRLDHAEADRQELQDELRQEREARQKLEMMIKELKLQILKSSKTAKE 664
             +  EL+ +L  A+    ELQ+++ Q+ +  + +++ +   K +  +SS+  K+
Sbjct: 342 EKKTLELKDKLTTADKLLGELQEQIVQKNQEIKNMKLELTNSKQKERQSSEEIKQ 396



 Score = 36.2 bits (82), Expect = 0.100
 Identities = 39/173 (22%), Positives = 79/173 (45%), Gaps = 36/173 (20%)

Query: 504  EDDKGKIMEEVMRTYLKQQEKLNLILQ------KKQQLQMEVKMLSSSKSMKELTEEQQN 557
            E +  K  +E++   ++Q++   L +Q      K +  +++ ++ S    + EL  E   
Sbjct: 3103 EQESEKPSQELLEYNIQQKQSQMLEMQVELSSMKDRATELQEQLSSEKMVVAELKSELAQ 3162

Query: 558  LQKELESL---QNEHAQRMEEFYVEQKDL--------------EKKLEQIM----KQKCT 596
             + ELE+    Q++H + +E F +E KD               +KK  ++     K+K  
Sbjct: 3163 TKLELETTLKAQHKHLKELEAFRLEVKDKTDEVHLLNDTLASEQKKSRELQWALEKEKAK 3222

Query: 597  CDSNLEKDKEAEYAGQLAELRQRLDHAEADRQELQDELRQER----EARQKLE 645
               + E+DKE     +L +L+  L+  +    +L   L Q++    E++QK+E
Sbjct: 3223 LGRSEERDKE-----ELEDLKFSLESQKQRNLQLNLLLEQQKQLLNESQQKIE 3270



 Score = 35.4 bits (80), Expect = 0.17
 Identities = 57/284 (20%), Positives = 131/284 (46%), Gaps = 30/284 (10%)

Query: 393  VSLTSAVSQSKELTKTEASKSI---SRQSEKAHSSGKLQKTVSYPDVSLEEQE--KMDLK 447
            V L+S   ++ EL +  +S+ +     +SE A +  +L+ T+      L+E E  ++++K
Sbjct: 3130 VELSSMKDRATELQEQLSSEKMVVAELKSELAQTKLELETTLKAQHKHLKELEAFRLEVK 3189

Query: 448  TSRELCSRLDASISNNSTSKRKSESATCNLVRDINKVGIG-------------LVAAASS 494
               +    L+ ++++     R+ + A   L ++  K+G                + +   
Sbjct: 3190 DKTDEVHLLNDTLASEQKKSRELQWA---LEKEKAKLGRSEERDKEELEDLKFSLESQKQ 3246

Query: 495  PLLVKDVICEDDKGKIMEEVMRTYLKQQEKLNLILQKKQQLQMEVKMLSSSKSMKELTEE 554
              L  +++ E  K +++ E  +    Q+   +  L ++Q   +E+++L  S+ ++ + E 
Sbjct: 3247 RNLQLNLLLEQQK-QLLNESQQKIESQRMLYDAQLSEEQGRNLELQVLLESEKVR-IREM 3304

Query: 555  QQNLQKELE---SLQNEHAQRMEEFYVEQKDLEKKLEQIMKQKCTCDSNLEKDKEAEYAG 611
               L +E E    LQ+          +  +DL K+L++ +++K +    L  + E +Y  
Sbjct: 3305 SSTLDRERELHAQLQSSDGTGQSRPPLPSEDLLKELQKQLEEKHSRIVELLNETE-KYKL 3363

Query: 612  QLAELRQRLDHAEADRQELQDELRQEREARQKLEMMIKELKLQI 655
               + RQ++   E DRQ  +  L+ E+EA  + +  + EL+ ++
Sbjct: 3364 DSLQTRQQM---EKDRQVHRKTLQTEQEANTEGQKKMHELQSKV 3404



 Score = 34.3 bits (77), Expect = 0.38
 Identities = 32/152 (21%), Positives = 69/152 (45%), Gaps = 11/152 (7%)

Query: 522  QEKLNLILQKKQQLQ----MEVKMLSSSKSMKELTEEQQNLQKELESLQNEHAQRMEEFY 577
            ++ L  I +   QL+     + +++  S   K+   E    Q+EL    +E ++  E+  
Sbjct: 1855 EKLLEAISETSSQLEHAKVTQTELMRESFRQKQEATESLKCQEELRERLHEESRAREQLA 1914

Query: 578  VEQKDLEKKLEQIMKQKCTCDSNLEKDKEA--EYAGQLAELRQRLDHAEADRQELQDE-- 633
            VE    E  ++    +K   +  +++  +       +L     RL   EA++Q++Q+E  
Sbjct: 1915 VELSKAEGVIDGYADEKTLFERQIQEKTDIIDRLEQELLCASNRLQELEAEQQQIQEERE 1974

Query: 634  -LRQEREARQKLEMMIKELKLQILKSSKTAKE 664
             L +++EA +     +++  LQ  ++ K  KE
Sbjct: 1975 LLSRQKEAMKAEAGPVEQQLLQ--ETEKLMKE 2004



 Score = 34.3 bits (77), Expect = 0.38
 Identities = 35/156 (22%), Positives = 72/156 (46%), Gaps = 10/156 (6%)

Query: 511  MEEVMRTYLKQQEKLNLILQKKQQLQMEVKMLSSSKSMKELTEEQQNLQKELESLQNEHA 570
            + E+ +  L +  K    ++ K +L +EV++ +   ++    +E  NL+++LE  + E  
Sbjct: 2153 VRELEQALLVEDRKHFGAVEAKPELSLEVQLQAERDAIDRKEKEITNLEEQLEQFREELE 2212

Query: 571  QRMEEFYVEQKDLEKKLEQIMKQKCTCDSNLEKDKEAEYAGQLAELRQRLDHAEADRQEL 630
             + EE     + L  +LE   K+  T    LE++ +  +   + +L   L   E+D    
Sbjct: 2213 NKNEEV----QQLHMQLEIQKKESTTRLQELEQENKL-FKDDMEKL--GLAIKESDAMST 2265

Query: 631  QDE---LRQEREARQKLEMMIKELKLQILKSSKTAK 663
            QD+     +  +  Q+ E+ I +L  Q+ K  +  K
Sbjct: 2266 QDQHVLFGKFAQIIQEKEVEIDQLNEQVTKLQQQLK 2301



 Score = 29.6 bits (65), Expect = 9.3
 Identities = 37/141 (26%), Positives = 65/141 (46%), Gaps = 27/141 (19%)

Query: 520 KQQEKLNLILQKKQQLQMEVKMLSS--SKSMKELTEEQQNLQKELESLQNEHAQ--RMEE 575
           K +E+L LIL++K  LQ +++ L    S S +++   +Q + ++   L   H     +E+
Sbjct: 511 KLKEELGLILEEKCALQRQLEDLVEELSFSREQIQRARQTIAEQESKLNEAHKSLSTVED 570

Query: 576 FYVE-------QKDLEKK-----------LEQIMKQKCTCDSNLEKDKEAEYAGQLAELR 617
              E       +K+LE K           LE + K+K      + + +EAE    L  LR
Sbjct: 571 LKAEIVSASESRKELELKHEAEVTNYKIKLEMLEKEKNAVLDRMAESQEAE----LERLR 626

Query: 618 -QRLDHAEADRQELQDELRQE 637
            Q L   E +  +L+++L  E
Sbjct: 627 TQLLFSHEEELSKLKEDLEIE 647



 Score = 29.6 bits (65), Expect = 9.3
 Identities = 19/74 (25%), Positives = 36/74 (48%)

Query: 520  KQQEKLNLILQKKQQLQMEVKMLSSSKSMKELTEEQQNLQKELESLQNEHAQRMEEFYVE 579
            +Q + + L   ++   + E + LS    M  L +   N + +L SLQ+    ++EE   E
Sbjct: 1283 QQTDGMKLEFGEENLPKEETEFLSIHSQMTNLEDIDVNHKSKLSSLQDLEKTKLEEQVQE 1342

Query: 580  QKDLEKKLEQIMKQ 593
             + L   L+Q +K+
Sbjct: 1343 LESLISSLQQQLKE 1356


  Database: hs.faa
    Posted date:  Aug 4, 2009  4:42 PM
  Number of letters in database: 18,247,518
  Number of sequences in database:  37,866
  
Lambda     K      H
   0.314    0.128    0.366 

Gapped
Lambda     K      H
   0.267   0.0410    0.140 


Matrix: BLOSUM62
Gap Penalties: Existence: 11, Extension: 1
Number of Hits to DB: 25,379,697
Number of Sequences: 37866
Number of extensions: 1253202
Number of successful extensions: 11634
Number of sequences better than 10.0: 30
Number of HSP's better than 10.0 without gapping: 280
Number of HSP's successfully gapped in prelim test: 988
Number of HSP's that attempted gapping in prelim test: 5852
Number of HSP's gapped (non-prelim): 4388
length of query: 664
length of database: 18,247,518
effective HSP length: 109
effective length of query: 555
effective length of database: 14,120,124
effective search space: 7836668820
effective search space used: 7836668820
T: 11
A: 40
X1: 16 ( 7.2 bits)
X2: 38 (14.6 bits)
X3: 64 (24.7 bits)
S1: 42 (22.0 bits)
S2: 65 (29.6 bits)

Search results were obtained with NCBI BLAST and RefSeq entries.


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Guide to the Human Genome
Copyright © 2010 by Stewart Scherer. All rights reserved.

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