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Search of human proteins with 223029418
BLASTP 2.2.11 [Jun-05-2005]
Reference: Altschul, Stephen F., Thomas L. Madden, Alejandro A. Schaffer,
Jinghui Zhang, Zheng Zhang, Webb Miller, and David J. Lipman (1997),
"Gapped BLAST and PSI-BLAST: a new generation of protein database search
programs", Nucleic Acids Res. 25:3389-3402.
Query= gi|223029418 SKI-like isoform 1 [Homo sapiens]
(684 letters)
Database: hs.faa
37,866 sequences; 18,247,518 total letters
Searching..................................................done
Score E
Sequences producing significant alignments: (bits) Value
gi|223029418 SKI-like isoform 1 [Homo sapiens] 1366 0.0
gi|223029422 SKI-like isoform 3 [Homo sapiens] 1327 0.0
gi|223029420 SKI-like isoform 2 [Homo sapiens] 1253 0.0
gi|4506967 v-ski sarcoma viral oncogene homolog [Homo sapiens] 426 e-119
gi|239757043 PREDICTED: functional smad suppressing element 18 [... 121 2e-27
gi|239751555 PREDICTED: functional smad suppressing element 18 [... 121 2e-27
gi|239746067 PREDICTED: functional smad suppressing element 18 [... 121 2e-27
gi|73476377 LBXCOR1 homolog [Homo sapiens] 109 1e-23
gi|41406064 myosin, heavy polypeptide 10, non-muscle [Homo sapiens] 60 5e-09
gi|50897852 coiled-coil domain containing 88A isoform 2 [Homo sa... 59 2e-08
gi|208022632 coiled-coil domain containing 88A isoform 1 [Homo s... 59 2e-08
gi|41322923 plectin 1 isoform 11 [Homo sapiens] 57 7e-08
gi|41322914 plectin 1 isoform 10 [Homo sapiens] 57 7e-08
gi|41322919 plectin 1 isoform 8 [Homo sapiens] 57 7e-08
gi|41322910 plectin 1 isoform 7 [Homo sapiens] 57 7e-08
gi|41322916 plectin 1 isoform 6 [Homo sapiens] 57 7e-08
gi|41322908 plectin 1 isoform 3 [Homo sapiens] 57 7e-08
gi|41322912 plectin 1 isoform 2 [Homo sapiens] 57 7e-08
gi|47607492 plectin 1 isoform 1 [Homo sapiens] 57 7e-08
gi|21735548 centrosomal protein 2 [Homo sapiens] 56 1e-07
gi|63252902 tropomyosin 1 alpha chain isoform 2 [Homo sapiens] 55 2e-07
gi|41872583 Rho-associated, coiled-coil containing protein kinas... 55 3e-07
gi|148746195 trichohyalin [Homo sapiens] 54 4e-07
gi|31982906 cingulin-like 1 [Homo sapiens] 54 5e-07
gi|148596984 golgi autoantigen, golgin subfamily b, macrogolgin ... 54 5e-07
gi|239745095 PREDICTED: hypothetical protein LOC645202 [Homo sap... 54 6e-07
gi|71361682 nuclear mitotic apparatus protein 1 [Homo sapiens] 54 6e-07
gi|222418637 golgi autoantigen, golgin subfamily a-like [Homo sa... 53 8e-07
gi|22538387 A-kinase anchor protein 9 isoform 2 [Homo sapiens] 53 8e-07
gi|22538393 A-kinase anchor protein 9 isoform 3 [Homo sapiens] 53 8e-07
>gi|223029418 SKI-like isoform 1 [Homo sapiens]
Length = 684
Score = 1366 bits (3535), Expect = 0.0
Identities = 684/684 (100%), Positives = 684/684 (100%)
Query: 1 MENLQTNFSLVQGSTKKLNGMGDDGSPPAKKMITDIHANGKTINKVPTVKKEHLDDYGEA 60
MENLQTNFSLVQGSTKKLNGMGDDGSPPAKKMITDIHANGKTINKVPTVKKEHLDDYGEA
Sbjct: 1 MENLQTNFSLVQGSTKKLNGMGDDGSPPAKKMITDIHANGKTINKVPTVKKEHLDDYGEA 60
Query: 61 PVETDGEHVKRTCTSVPETLHLNPSLKHTLAQFHLSSQSSLGGPAAFSARHSQESMSPTV 120
PVETDGEHVKRTCTSVPETLHLNPSLKHTLAQFHLSSQSSLGGPAAFSARHSQESMSPTV
Sbjct: 61 PVETDGEHVKRTCTSVPETLHLNPSLKHTLAQFHLSSQSSLGGPAAFSARHSQESMSPTV 120
Query: 121 FLPLPSPQVLPGPLLIPSDSSTELTQTVLEGESISCFQVGGEKRLCLPQVLNSVLREFTL 180
FLPLPSPQVLPGPLLIPSDSSTELTQTVLEGESISCFQVGGEKRLCLPQVLNSVLREFTL
Sbjct: 121 FLPLPSPQVLPGPLLIPSDSSTELTQTVLEGESISCFQVGGEKRLCLPQVLNSVLREFTL 180
Query: 181 QQINTVCDELYIYCSRCTSDQLHILKVLGILPFNAPSCGLITLTDAQRLCNALLRPRTFP 240
QQINTVCDELYIYCSRCTSDQLHILKVLGILPFNAPSCGLITLTDAQRLCNALLRPRTFP
Sbjct: 181 QQINTVCDELYIYCSRCTSDQLHILKVLGILPFNAPSCGLITLTDAQRLCNALLRPRTFP 240
Query: 241 QNGSVLPAKSSLAQLKETGSAFEVEHECLGKCQGLFAPQFYVQPDAPCIQCLECCGMFAP 300
QNGSVLPAKSSLAQLKETGSAFEVEHECLGKCQGLFAPQFYVQPDAPCIQCLECCGMFAP
Sbjct: 241 QNGSVLPAKSSLAQLKETGSAFEVEHECLGKCQGLFAPQFYVQPDAPCIQCLECCGMFAP 300
Query: 301 QTFVMHSHRSPDKRTCHWGFESAKWHCYLHVNQKYLGTPEEKKLKIILEEMKEKFSMRSG 360
QTFVMHSHRSPDKRTCHWGFESAKWHCYLHVNQKYLGTPEEKKLKIILEEMKEKFSMRSG
Sbjct: 301 QTFVMHSHRSPDKRTCHWGFESAKWHCYLHVNQKYLGTPEEKKLKIILEEMKEKFSMRSG 360
Query: 361 KRNQSKTDAPSGMELQSWYPVIKQEGDHVSQTHSFLHPSYYLYMCDKVVAPNVSLTSAVS 420
KRNQSKTDAPSGMELQSWYPVIKQEGDHVSQTHSFLHPSYYLYMCDKVVAPNVSLTSAVS
Sbjct: 361 KRNQSKTDAPSGMELQSWYPVIKQEGDHVSQTHSFLHPSYYLYMCDKVVAPNVSLTSAVS 420
Query: 421 QSKELTKTEASKSISRQSEKAHSSGKLQKTVSYPDVSLEEQEKMDLKTSRELCSRLDASI 480
QSKELTKTEASKSISRQSEKAHSSGKLQKTVSYPDVSLEEQEKMDLKTSRELCSRLDASI
Sbjct: 421 QSKELTKTEASKSISRQSEKAHSSGKLQKTVSYPDVSLEEQEKMDLKTSRELCSRLDASI 480
Query: 481 SNNSTSKRKSESATCNLVRDINKVGIGLVAAASSPLLVKDVICEDDKGKIMEEVMRTYLK 540
SNNSTSKRKSESATCNLVRDINKVGIGLVAAASSPLLVKDVICEDDKGKIMEEVMRTYLK
Sbjct: 481 SNNSTSKRKSESATCNLVRDINKVGIGLVAAASSPLLVKDVICEDDKGKIMEEVMRTYLK 540
Query: 541 QQEKLNLILQKKQQLQMEVKMLSSSKSMKELTEEQQNLQKELESLQNEHAQRMEEFYVEQ 600
QQEKLNLILQKKQQLQMEVKMLSSSKSMKELTEEQQNLQKELESLQNEHAQRMEEFYVEQ
Sbjct: 541 QQEKLNLILQKKQQLQMEVKMLSSSKSMKELTEEQQNLQKELESLQNEHAQRMEEFYVEQ 600
Query: 601 KDLEKKLEQIMKQKCTCDSNLEKDKEAEYAGQLAELRQRLDHAEADRQELQDELRQEREA 660
KDLEKKLEQIMKQKCTCDSNLEKDKEAEYAGQLAELRQRLDHAEADRQELQDELRQEREA
Sbjct: 601 KDLEKKLEQIMKQKCTCDSNLEKDKEAEYAGQLAELRQRLDHAEADRQELQDELRQEREA 660
Query: 661 RQKLEMMIKELKLQILKSSKTAKE 684
RQKLEMMIKELKLQILKSSKTAKE
Sbjct: 661 RQKLEMMIKELKLQILKSSKTAKE 684
>gi|223029422 SKI-like isoform 3 [Homo sapiens]
Length = 664
Score = 1327 bits (3435), Expect = 0.0
Identities = 664/664 (100%), Positives = 664/664 (100%)
Query: 21 MGDDGSPPAKKMITDIHANGKTINKVPTVKKEHLDDYGEAPVETDGEHVKRTCTSVPETL 80
MGDDGSPPAKKMITDIHANGKTINKVPTVKKEHLDDYGEAPVETDGEHVKRTCTSVPETL
Sbjct: 1 MGDDGSPPAKKMITDIHANGKTINKVPTVKKEHLDDYGEAPVETDGEHVKRTCTSVPETL 60
Query: 81 HLNPSLKHTLAQFHLSSQSSLGGPAAFSARHSQESMSPTVFLPLPSPQVLPGPLLIPSDS 140
HLNPSLKHTLAQFHLSSQSSLGGPAAFSARHSQESMSPTVFLPLPSPQVLPGPLLIPSDS
Sbjct: 61 HLNPSLKHTLAQFHLSSQSSLGGPAAFSARHSQESMSPTVFLPLPSPQVLPGPLLIPSDS 120
Query: 141 STELTQTVLEGESISCFQVGGEKRLCLPQVLNSVLREFTLQQINTVCDELYIYCSRCTSD 200
STELTQTVLEGESISCFQVGGEKRLCLPQVLNSVLREFTLQQINTVCDELYIYCSRCTSD
Sbjct: 121 STELTQTVLEGESISCFQVGGEKRLCLPQVLNSVLREFTLQQINTVCDELYIYCSRCTSD 180
Query: 201 QLHILKVLGILPFNAPSCGLITLTDAQRLCNALLRPRTFPQNGSVLPAKSSLAQLKETGS 260
QLHILKVLGILPFNAPSCGLITLTDAQRLCNALLRPRTFPQNGSVLPAKSSLAQLKETGS
Sbjct: 181 QLHILKVLGILPFNAPSCGLITLTDAQRLCNALLRPRTFPQNGSVLPAKSSLAQLKETGS 240
Query: 261 AFEVEHECLGKCQGLFAPQFYVQPDAPCIQCLECCGMFAPQTFVMHSHRSPDKRTCHWGF 320
AFEVEHECLGKCQGLFAPQFYVQPDAPCIQCLECCGMFAPQTFVMHSHRSPDKRTCHWGF
Sbjct: 241 AFEVEHECLGKCQGLFAPQFYVQPDAPCIQCLECCGMFAPQTFVMHSHRSPDKRTCHWGF 300
Query: 321 ESAKWHCYLHVNQKYLGTPEEKKLKIILEEMKEKFSMRSGKRNQSKTDAPSGMELQSWYP 380
ESAKWHCYLHVNQKYLGTPEEKKLKIILEEMKEKFSMRSGKRNQSKTDAPSGMELQSWYP
Sbjct: 301 ESAKWHCYLHVNQKYLGTPEEKKLKIILEEMKEKFSMRSGKRNQSKTDAPSGMELQSWYP 360
Query: 381 VIKQEGDHVSQTHSFLHPSYYLYMCDKVVAPNVSLTSAVSQSKELTKTEASKSISRQSEK 440
VIKQEGDHVSQTHSFLHPSYYLYMCDKVVAPNVSLTSAVSQSKELTKTEASKSISRQSEK
Sbjct: 361 VIKQEGDHVSQTHSFLHPSYYLYMCDKVVAPNVSLTSAVSQSKELTKTEASKSISRQSEK 420
Query: 441 AHSSGKLQKTVSYPDVSLEEQEKMDLKTSRELCSRLDASISNNSTSKRKSESATCNLVRD 500
AHSSGKLQKTVSYPDVSLEEQEKMDLKTSRELCSRLDASISNNSTSKRKSESATCNLVRD
Sbjct: 421 AHSSGKLQKTVSYPDVSLEEQEKMDLKTSRELCSRLDASISNNSTSKRKSESATCNLVRD 480
Query: 501 INKVGIGLVAAASSPLLVKDVICEDDKGKIMEEVMRTYLKQQEKLNLILQKKQQLQMEVK 560
INKVGIGLVAAASSPLLVKDVICEDDKGKIMEEVMRTYLKQQEKLNLILQKKQQLQMEVK
Sbjct: 481 INKVGIGLVAAASSPLLVKDVICEDDKGKIMEEVMRTYLKQQEKLNLILQKKQQLQMEVK 540
Query: 561 MLSSSKSMKELTEEQQNLQKELESLQNEHAQRMEEFYVEQKDLEKKLEQIMKQKCTCDSN 620
MLSSSKSMKELTEEQQNLQKELESLQNEHAQRMEEFYVEQKDLEKKLEQIMKQKCTCDSN
Sbjct: 541 MLSSSKSMKELTEEQQNLQKELESLQNEHAQRMEEFYVEQKDLEKKLEQIMKQKCTCDSN 600
Query: 621 LEKDKEAEYAGQLAELRQRLDHAEADRQELQDELRQEREARQKLEMMIKELKLQILKSSK 680
LEKDKEAEYAGQLAELRQRLDHAEADRQELQDELRQEREARQKLEMMIKELKLQILKSSK
Sbjct: 601 LEKDKEAEYAGQLAELRQRLDHAEADRQELQDELRQEREARQKLEMMIKELKLQILKSSK 660
Query: 681 TAKE 684
TAKE
Sbjct: 661 TAKE 664
>gi|223029420 SKI-like isoform 2 [Homo sapiens]
Length = 638
Score = 1253 bits (3243), Expect = 0.0
Identities = 636/684 (92%), Positives = 637/684 (93%), Gaps = 46/684 (6%)
Query: 1 MENLQTNFSLVQGSTKKLNGMGDDGSPPAKKMITDIHANGKTINKVPTVKKEHLDDYGEA 60
MENLQTNFSLVQGSTKKLNGMGDDGSPPAKKMITDIHANGKTINKVPTVKKEHLDDYGEA
Sbjct: 1 MENLQTNFSLVQGSTKKLNGMGDDGSPPAKKMITDIHANGKTINKVPTVKKEHLDDYGEA 60
Query: 61 PVETDGEHVKRTCTSVPETLHLNPSLKHTLAQFHLSSQSSLGGPAAFSARHSQESMSPTV 120
PVETDGEHVKRTCTSVPETLHLNPSLKHTLAQFHLSSQSSLGGPAAFSARHSQESMSPTV
Sbjct: 61 PVETDGEHVKRTCTSVPETLHLNPSLKHTLAQFHLSSQSSLGGPAAFSARHSQESMSPTV 120
Query: 121 FLPLPSPQVLPGPLLIPSDSSTELTQTVLEGESISCFQVGGEKRLCLPQVLNSVLREFTL 180
FLPLPSPQVLPGPLLIPSDSSTELTQTVLEGESISCFQVGGEKRLCLPQVLNSVLREFTL
Sbjct: 121 FLPLPSPQVLPGPLLIPSDSSTELTQTVLEGESISCFQVGGEKRLCLPQVLNSVLREFTL 180
Query: 181 QQINTVCDELYIYCSRCTSDQLHILKVLGILPFNAPSCGLITLTDAQRLCNALLRPRTFP 240
QQINTVCDELYIYCSRCTSDQLHILKVLGILPFNAPSCGLITLTDAQRLCNALLRPRTFP
Sbjct: 181 QQINTVCDELYIYCSRCTSDQLHILKVLGILPFNAPSCGLITLTDAQRLCNALLRPRTFP 240
Query: 241 QNGSVLPAKSSLAQLKETGSAFEVEHECLGKCQGLFAPQFYVQPDAPCIQCLECCGMFAP 300
QNGSVLPAKSSLAQLKETGSAFEVEHECLGKCQGLFAPQFYVQPDAPCIQCLECCGMFAP
Sbjct: 241 QNGSVLPAKSSLAQLKETGSAFEVEHECLGKCQGLFAPQFYVQPDAPCIQCLECCGMFAP 300
Query: 301 QTFVMHSHRSPDKRTCHWGFESAKWHCYLHVNQKYLGTPEEKKLKIILEEMKEKFSMRSG 360
QTFVMHSHRSPDKRTCHWGFESAKWHCYLHVNQKYLGTPEEKKLKIILEEMKEKFSMRSG
Sbjct: 301 QTFVMHSHRSPDKRTCHWGFESAKWHCYLHVNQKYLGTPEEKKLKIILEEMKEKFSMRSG 360
Query: 361 KRNQSKTDAPSGMELQSWYPVIKQEGDHVSQTHSFLHPSYYLYMCDKVVAPNVSLTSAVS 420
KRNQSKTDAPSGMELQSWYPVIKQEGDHVSQTHSFLHPSYYLYMCDKVVAPNVSLTSAVS
Sbjct: 361 KRNQSKTDAPSGMELQSWYPVIKQEGDHVSQTHSFLHPSYYLYMCDKVVAPNVSLTSAVS 420
Query: 421 QSKELTKTEASKSISRQSEKAHSSGKLQKTVSYPDVSLEEQEKMDLKTSRELCSRLDASI 480
QSKELTKTEA+ SIS
Sbjct: 421 QSKELTKTEANASIS--------------------------------------------- 435
Query: 481 SNNSTSKRKSESATCNLVRDINKVGIGLVAAASSPLLVKDVICEDDKGKIMEEVMRTYLK 540
NNSTSKRKSESATCNLVRDINKVGIGLVAAASSPLLVKDVICEDDKGKIMEEVMRTYLK
Sbjct: 436 -NNSTSKRKSESATCNLVRDINKVGIGLVAAASSPLLVKDVICEDDKGKIMEEVMRTYLK 494
Query: 541 QQEKLNLILQKKQQLQMEVKMLSSSKSMKELTEEQQNLQKELESLQNEHAQRMEEFYVEQ 600
QQEKLNLILQKKQQLQMEVKMLSSSKSMKELTEEQQNLQKELESLQNEHAQRMEEFYVEQ
Sbjct: 495 QQEKLNLILQKKQQLQMEVKMLSSSKSMKELTEEQQNLQKELESLQNEHAQRMEEFYVEQ 554
Query: 601 KDLEKKLEQIMKQKCTCDSNLEKDKEAEYAGQLAELRQRLDHAEADRQELQDELRQEREA 660
KDLEKKLEQIMKQKCTCDSNLEKDKEAEYAGQLAELRQRLDHAEADRQELQDELRQEREA
Sbjct: 555 KDLEKKLEQIMKQKCTCDSNLEKDKEAEYAGQLAELRQRLDHAEADRQELQDELRQEREA 614
Query: 661 RQKLEMMIKELKLQILKSSKTAKE 684
RQKLEMMIKELKLQILKSSKTAKE
Sbjct: 615 RQKLEMMIKELKLQILKSSKTAKE 638
>gi|4506967 v-ski sarcoma viral oncogene homolog [Homo sapiens]
Length = 728
Score = 426 bits (1095), Expect = e-119
Identities = 262/698 (37%), Positives = 384/698 (55%), Gaps = 107/698 (15%)
Query: 83 NPSLKHTLAQFHLSSQSSLGGPAAFSARHSQESMS-----------------------PT 119
+P L+ TL QFHLSS SSLGGPAAFSAR +QE+ P
Sbjct: 14 HPGLQKTLEQFHLSSMSSLGGPAAFSARWAQEAYKKESAKEAGAAAVPAPVPAATEPPPV 73
Query: 120 VFLPL--PSPQVLPGPLLIPSDSSTELTQTVLEGESISCFQVGGEKRLCLPQVLNSVLRE 177
+ LP P P VLPGP +PSD STE +TVLEGE+ISCF VGGEKRLCLPQ+LNSVLR+
Sbjct: 74 LHLPAIQPPPPVLPGPFFMPSDRSTERCETVLEGETISCFVVGGEKRLCLPQILNSVLRD 133
Query: 178 FTLQQINTVCDELYIYCSRCTSDQLHILKVLGILPFNAPSCGLITLTDAQRLCNALLRPR 237
F+LQQIN VCDEL+IYCSRCT+DQL ILKV+GILPF+APSCGLIT TDA+RLCNALL
Sbjct: 134 FSLQQINAVCDELHIYCSRCTADQLEILKVMGILPFSAPSCGLITKTDAERLCNALLYGG 193
Query: 238 TFPQNGSVLPAKSSLAQLKETGSAFEVEHECLGKCQGLFAPQFYVQPDAPCIQCLECCGM 297
+P A S L+ + + V HEC GKC+GL P+ Y P A CIQCL+C M
Sbjct: 194 AYPPPCKKELAASLALGLELSERSVRVYHECFGKCKGLLVPELYSSPSAACIQCLDCRLM 253
Query: 298 FAPQTFVMHSHRSPDKRTCHWGFESAKWHCYLHVNQKYLGTPEEKKLKIILEEMKEKFSM 357
+ P FV+HSH++ + RTCHWGF+SA W Y+ ++Q Y G E+ +L L+++KEKF
Sbjct: 254 YPPHKFVVHSHKALENRTCHWGFDSANWRAYILLSQDYTGKEEQARLGRCLDDVKEKFDY 313
Query: 358 RSGKRNQ--------------------SKTDAPSGMELQS-------------------- 377
+ + + S++ APS + S
Sbjct: 314 GNKYKRRVPRVSSEPPASIRPKTDDTSSQSPAPSEKDKPSSWLRTLAGSSNKSLGCVHPR 373
Query: 378 --------WYPVIKQEGDHVS-QTHSFLHPSYYLYMC-DKVVAPNVSLTSAVSQSKELTK 427
W P + +S + + S+Y Y + VAPNV+L + +Q K ++
Sbjct: 374 QRLSAFRPWSPAVSASEKELSPHLPALIRDSFYSYKSFETAVAPNVAL-APPAQQKVVSS 432
Query: 428 TEASKSISRQSEKAHSSGKLQK---------------TVSYPDVSLEEQEKMDLKTSREL 472
+ ++SR E + + +K V+ P+ + + ++++++ E
Sbjct: 433 PPCAAAVSRAPEPLATCTQPRKRKLTVDTPGAPETLAPVAAPEEDKDSEAEVEVESREEF 492
Query: 473 CSRLDASISNNSTSKRKSESATCNLVRDINKVGIGLVAAASSP------------LLVKD 520
S L + S + TS ++ R + A A +P L
Sbjct: 493 TSSLSSLSSPSFTSSSSAKDLGSPGARALPSAVPDAAAPADAPSGLEAELEHLRQALEGG 552
Query: 521 VICEDDKGKIMEEVMRTYLKQQEKLNLILQKKQQLQMEVKMLSSSK--SMKELTEEQQNL 578
+ ++ K K + EV++ +KQ+EKL+ LQ K+ L E++ L +K ++E TE ++NL
Sbjct: 553 LDTKEAKEKFLHEVVKMRVKQEEKLSAALQAKRSLHQELEFLRVAKKEKLREATEAKRNL 612
Query: 579 QKELESLQNEHAQRMEEFYVEQKDLEKKLEQIMKQKCTCDSNLEKDK-EAEYAGQLAELR 637
+KE+E L+ E+ ++M+E + L+++LEQ +Q CD E + A+Y+ Q+ +L+
Sbjct: 613 RKEIERLRAENEKKMKEANESRLRLKRELEQ-ARQARVCDKGCEAGRLRAKYSAQIEDLQ 671
Query: 638 QRLDHAEADRQELQDELRQEREARQKLEMMIKELKLQI 675
+L HAEADR++L+ +L +EREAR+ LE ++KEL+ Q+
Sbjct: 672 VKLQHAEADREQLRADLLREREAREHLEKVVKELQEQL 709
>gi|239757043 PREDICTED: functional smad suppressing element 18
[Homo sapiens]
Length = 996
Score = 121 bits (304), Expect = 2e-27
Identities = 83/252 (32%), Positives = 119/252 (47%), Gaps = 30/252 (11%)
Query: 120 VFLPLPSPQVLPGPLLIPSDSSTELT-----QTVLEGESISCFQVGGEKRLCLPQVLNSV 174
+ L PS P L P L Q +L G I + G++RLCL Q+ N++
Sbjct: 12 ILLASPSSAFQPDTLSQPRPGHANLKPNQVGQVILYGIPIVSLVIDGQERLCLAQISNTL 71
Query: 175 LREFTLQQINTVCDELYIYCSRCTSDQLHILKVLGILPFNAPSCGLITLTDAQRLCNALL 234
L+ F+ +I+ L I C +CT QL IL+ G +P ++ CG+IT +A+RLC + L
Sbjct: 72 LKNFSYNEIHNRRVALGITCVQCTPVQLEILRRAGAMPISSRRCGMITKREAERLCKSFL 131
Query: 235 ---RPRTFPQNGSVLPAKSSLAQLKETGSAFEVEHECLGKCQGLFAPQFYVQPDAPCIQC 291
RP P N AF+V HEC C+G F P Y A CI+C
Sbjct: 132 GENRPPKLPDN-----------------FAFDVSHECAWGCRGSFIPARYNSSRAKCIKC 174
Query: 292 LECCGMFAPQTFVMHSHRSPD-KRTCHWGFESAKWHCYLHVNQKYLGTPEEKKLKIILEE 350
C F+P F+ HSHR+PD K T W +L + K +P++ +L E+
Sbjct: 175 SYCNMYFSPNKFIFHSHRTPDAKYTQPDAANFNSWRRHLKLTDK---SPQD-ELVFAWED 230
Query: 351 MKEKFSMRSGKR 362
+K F+ S KR
Sbjct: 231 VKAMFNGGSRKR 242
>gi|239751555 PREDICTED: functional smad suppressing element 18
[Homo sapiens]
Length = 1252
Score = 121 bits (304), Expect = 2e-27
Identities = 83/252 (32%), Positives = 119/252 (47%), Gaps = 30/252 (11%)
Query: 120 VFLPLPSPQVLPGPLLIPSDSSTELT-----QTVLEGESISCFQVGGEKRLCLPQVLNSV 174
+ L PS P L P L Q +L G I + G++RLCL Q+ N++
Sbjct: 12 ILLASPSSAFQPDTLSQPRPGHANLKPNQVGQVILYGIPIVSLVIDGQERLCLAQISNTL 71
Query: 175 LREFTLQQINTVCDELYIYCSRCTSDQLHILKVLGILPFNAPSCGLITLTDAQRLCNALL 234
L+ F+ +I+ L I C +CT QL IL+ G +P ++ CG+IT +A+RLC + L
Sbjct: 72 LKNFSYNEIHNRRVALGITCVQCTPVQLEILRRAGAMPISSRRCGMITKREAERLCKSFL 131
Query: 235 ---RPRTFPQNGSVLPAKSSLAQLKETGSAFEVEHECLGKCQGLFAPQFYVQPDAPCIQC 291
RP P N AF+V HEC C+G F P Y A CI+C
Sbjct: 132 GENRPPKLPDN-----------------FAFDVSHECAWGCRGSFIPARYNSSRAKCIKC 174
Query: 292 LECCGMFAPQTFVMHSHRSPD-KRTCHWGFESAKWHCYLHVNQKYLGTPEEKKLKIILEE 350
C F+P F+ HSHR+PD K T W +L + K +P++ +L E+
Sbjct: 175 SYCNMYFSPNKFIFHSHRTPDAKYTQPDAANFNSWRRHLKLTDK---SPQD-ELVFAWED 230
Query: 351 MKEKFSMRSGKR 362
+K F+ S KR
Sbjct: 231 VKAMFNGGSRKR 242
>gi|239746067 PREDICTED: functional smad suppressing element 18
[Homo sapiens]
Length = 1252
Score = 121 bits (304), Expect = 2e-27
Identities = 83/252 (32%), Positives = 119/252 (47%), Gaps = 30/252 (11%)
Query: 120 VFLPLPSPQVLPGPLLIPSDSSTELT-----QTVLEGESISCFQVGGEKRLCLPQVLNSV 174
+ L PS P L P L Q +L G I + G++RLCL Q+ N++
Sbjct: 12 ILLASPSSAFQPDTLSQPRPGHANLKPNQVGQVILYGIPIVSLVIDGQERLCLAQISNTL 71
Query: 175 LREFTLQQINTVCDELYIYCSRCTSDQLHILKVLGILPFNAPSCGLITLTDAQRLCNALL 234
L+ F+ +I+ L I C +CT QL IL+ G +P ++ CG+IT +A+RLC + L
Sbjct: 72 LKNFSYNEIHNRRVALGITCVQCTPVQLEILRRAGAMPISSRRCGMITKREAERLCKSFL 131
Query: 235 ---RPRTFPQNGSVLPAKSSLAQLKETGSAFEVEHECLGKCQGLFAPQFYVQPDAPCIQC 291
RP P N AF+V HEC C+G F P Y A CI+C
Sbjct: 132 GENRPPKLPDN-----------------FAFDVSHECAWGCRGSFIPARYNSSRAKCIKC 174
Query: 292 LECCGMFAPQTFVMHSHRSPD-KRTCHWGFESAKWHCYLHVNQKYLGTPEEKKLKIILEE 350
C F+P F+ HSHR+PD K T W +L + K +P++ +L E+
Sbjct: 175 SYCNMYFSPNKFIFHSHRTPDAKYTQPDAANFNSWRRHLKLTDK---SPQD-ELVFAWED 230
Query: 351 MKEKFSMRSGKR 362
+K F+ S KR
Sbjct: 231 VKAMFNGGSRKR 242
>gi|73476377 LBXCOR1 homolog [Homo sapiens]
Length = 921
Score = 109 bits (272), Expect = 1e-23
Identities = 60/175 (34%), Positives = 92/175 (52%), Gaps = 20/175 (11%)
Query: 143 ELTQTVLEGESISCFQVGGEKRLCLPQVLNSVLREFTLQQINTVCDELYIYCSRCTSDQL 202
++ +T L G I + G++RLCL Q+ N++L+ ++ +I+ L I C +CT QL
Sbjct: 67 QVGETSLYGVPIVSLVIDGQERLCLAQISNTLLKNYSYNEIHNRRVALGITCVQCTPVQL 126
Query: 203 HILKVLGILPFNAPSCGLITLTDAQRLCNALL---RPRTFPQNGSVLPAKSSLAQLKETG 259
IL+ G +P ++ CG+IT +A+RLC + L +P P+N
Sbjct: 127 EILRRAGAMPISSRRCGMITKREAERLCKSFLGEHKPPKLPEN----------------- 169
Query: 260 SAFEVEHECLGKCQGLFAPQFYVQPDAPCIQCLECCGMFAPQTFVMHSHRSPDKR 314
AF+V HEC +G F P Y A CI+C C F+P F+ HSHR+PD +
Sbjct: 170 FAFDVVHECAWGSRGSFIPARYNSSRAKCIKCGYCSMYFSPNKFIFHSHRTPDAK 224
Score = 40.0 bits (92), Expect = 0.007
Identities = 26/93 (27%), Positives = 51/93 (54%), Gaps = 10/93 (10%)
Query: 578 LQKELESLQNEHAQRMEEFYVEQKDLEKKLEQIMKQKCTCDSNLEKDKEAEYAGQLAELR 637
++K++E+L E Q++ +EQ +L KKLE+ + +L+ + + + +LA
Sbjct: 809 VEKDIENLAREELQKL---LLEQMELRKKLEREFQ-------SLKDNFQDQMKRELAYRE 858
Query: 638 QRLDHAEADRQELQDELRQEREARQKLEMMIKE 670
+ + + R L +EL QER+AR ++ +KE
Sbjct: 859 EMVQQLQIVRDTLCNELDQERKARYAIQQKLKE 891
>gi|41406064 myosin, heavy polypeptide 10, non-muscle [Homo sapiens]
Length = 1976
Score = 60.5 bits (145), Expect = 5e-09
Identities = 70/290 (24%), Positives = 132/290 (45%), Gaps = 35/290 (12%)
Query: 414 SLTSAVSQSKELTKTEASKSISRQSEKAHSSGKLQKTVSYPDVSLEEQEKMDLKTSRELC 473
SL S + ++EL + E +K + S ++++ + SL+EQ++ + + + L
Sbjct: 1312 SLESQLQDTQELLQEETR-------QKLNLSSRIRQLEEEKN-SLQEQQEEEEEARKNLE 1363
Query: 474 SRLDASISNNSTSKRKSES--ATCNLVRDINKVGIGLVAAASSPLLVKDVI---CEDDKG 528
++ A S + +K+K + T + + K + A S L K + E K
Sbjct: 1364 KQVLALQSQLADTKKKVDDDLGTIESLEEAKKKLLKDAEALSQRLEEKALAYDKLEKTKN 1423
Query: 529 KIMEEV--MRTYLKQQEKLNLILQKKQ----QLQMEVKMLSSSKSMKELTEEQQNLQKEL 582
++ +E+ + L Q ++ L+KKQ QL E K +S+ + + E + +KE
Sbjct: 1424 RLQQELDDLTVDLDHQRQVASNLEKKQKKFDQLLAEEKSISARYAEERDRAEAEAREKET 1483
Query: 583 ESLQ-----NEHAQRMEEFYVEQKDLEKKLEQIMKQKCTCDSN---LEKDKEAEYAGQLA 634
++L E + EEF + K L +E +M K N LEK K A
Sbjct: 1484 KALSLARALEEALEAKEEFERQNKQLRADMEDLMSSKDDVGKNVHELEKSKRA------- 1536
Query: 635 ELRQRLDHAEADRQELQDELRQEREARQKLEMMIKELKLQILKSSKTAKE 684
L Q+++ +EL+DEL+ +A+ +LE+ ++ +K Q + +T E
Sbjct: 1537 -LEQQVEEMRTQLEELEDELQATEDAKLRLEVNMQAMKAQFERDLQTRDE 1585
Score = 56.6 bits (135), Expect = 7e-08
Identities = 59/264 (22%), Positives = 116/264 (43%), Gaps = 31/264 (11%)
Query: 419 VSQSKELTKTEASKSISRQSEKAHSSGKLQKTVSYPDVSLEEQEKMDLKTSRELCSRLDA 478
+S+ E KTE ++ + + K ++ V+ +LEE+ K +++ R
Sbjct: 1144 LSEELEALKTELEDTLDTTAAQQELRTKREQEVAELKKALEEETKNHEAQIQDMRQRHAT 1203
Query: 479 SISNNSTSKRKSESATCNLVRDINKVGIGLVAAASSPLLVKDVICEDDKGKIMEEVMRTY 538
++ S +++ NL + NK G+ K++ CE K++++V
Sbjct: 1204 ALEELSEQLEQAKRFKANLEK--NKQGLETDN--------KELACEV---KVLQQVKAES 1250
Query: 539 LKQQEKLNLILQKKQQLQMEVKMLSSSKSMKELTEEQQNLQKELESLQNEHAQRMEEFYV 598
+++KL+ +Q ++ K+ + EL E+ LQ EL+++ +EE
Sbjct: 1251 EHKRKKLDAQVQ-----ELHAKVSEGDRLRVELAEKASKLQNELDNVST----LLEE--- 1298
Query: 599 EQKDLEKKLEQIMKQKCTCDSNLEKDKEA--EYAGQLAELRQRLDHAEADRQELQDELRQ 656
EKK + K + +S L+ +E E Q L R+ E ++ LQ++ +
Sbjct: 1299 ----AEKKGIKFAKDAASLESQLQDTQELLQEETRQKLNLSSRIRQLEEEKNSLQEQQEE 1354
Query: 657 EREARQKLEMMIKELKLQILKSSK 680
E EAR+ LE + L+ Q+ + K
Sbjct: 1355 EEEARKNLEKQVLALQSQLADTKK 1378
Score = 48.9 bits (115), Expect = 2e-05
Identities = 70/336 (20%), Positives = 137/336 (40%), Gaps = 68/336 (20%)
Query: 407 KVVAPNVSLTSAVSQSKELTKTEASKSISRQSEKAHSSGKLQKTVSYPDVSLEEQEKMDL 466
K V ++ ++ ++K+ +A R EKA + KL+KT + L++ +DL
Sbjct: 1378 KKVDDDLGTIESLEEAKKKLLKDAEALSQRLEEKALAYDKLEKTKNRLQQELDDL-TVDL 1436
Query: 467 KTSRELCSRL-------------DASISNNSTSKRKSESATCNLVRDINKVGIGLVAAAS 513
R++ S L + SIS +R A R+ + L A
Sbjct: 1437 DHQRQVASNLEKKQKKFDQLLAEEKSISARYAEERDRAEAE---AREKETKALSLARALE 1493
Query: 514 SPLLVKD----------------VICEDDKGKIMEEV-------------MRTYLKQ-QE 543
L K+ + +DD GK + E+ MRT L++ ++
Sbjct: 1494 EALEAKEEFERQNKQLRADMEDLMSSKDDVGKNVHELEKSKRALEQQVEEMRTQLEELED 1553
Query: 544 KLNLILQKKQQLQMEVKMLSSSKSMKELTEEQQNLQK---------ELES-LQNEHAQR- 592
+L K +L++ ++ + + T ++QN +K ELE+ L++E QR
Sbjct: 1554 ELQATEDAKLRLEVNMQAMKAQFERDLQTRDEQNEEKKRLLIKQVRELEAELEDERKQRA 1613
Query: 593 -----MEEFYVEQKDLEKKLEQIMKQKCTCDSNLEKDKEAEYAGQLAELRQRLDHAEADR 647
++ ++ KDLE ++E K + L K Q+ + ++ L+ A A R
Sbjct: 1614 LAVASKKKMEIDLKDLEAQIEAANKARDEVIKQLRK-----LQAQMKDYQRELEEARASR 1668
Query: 648 QELQDELRQEREARQKLEMMIKELKLQILKSSKTAK 683
E+ + ++ + + LE I +L+ ++ S + +
Sbjct: 1669 DEIFAQSKESEKKLKSLEAEILQLQEELASSERARR 1704
Score = 48.5 bits (114), Expect = 2e-05
Identities = 40/181 (22%), Positives = 91/181 (50%), Gaps = 30/181 (16%)
Query: 531 MEEVMRTYLKQQEKLNLILQKKQQLQMEVKMLSSSKSMK-ELTEEQQNLQK---ELESLQ 586
+EE+ R + + E+ N++ + QLQ E ++ + ++ M+ L ++Q L++ +LES
Sbjct: 875 LEEMERKHQQLLEEKNILAE---QLQAETELFAEAEEMRARLAAKKQELEEILHDLESRV 931
Query: 587 NEHAQRMEEFYVEQK-------DLEKKLEQ-------IMKQKCTCDSNLEK--------- 623
E +R + E+K DLE++L++ + +K T ++ ++K
Sbjct: 932 EEEEERNQILQNEKKKMQAHIQDLEEQLDEEEGARQKLQLEKVTAEAKIKKMEEEILLLE 991
Query: 624 DKEAEYAGQLAELRQRLDHAEADRQELQDELRQEREARQKLEMMIKELKLQILKSSKTAK 683
D+ +++ + + R+ + E +++ + + R K E+MI +L+ ++ K KT +
Sbjct: 992 DQNSKFIKEKKLMEDRIAECSSQLAEEEEKAKNLAKIRNKQEVMISDLEERLKKEEKTRQ 1051
Query: 684 E 684
E
Sbjct: 1052 E 1052
Score = 48.5 bits (114), Expect = 2e-05
Identities = 69/356 (19%), Positives = 154/356 (43%), Gaps = 41/356 (11%)
Query: 340 EEKKLKII-----LEEMKEKFSMRSGKRNQSKTDAPSGMELQSWYPVIKQEGDHVSQTHS 394
EE K K++ L + E+ ++ K ++K LQ + + DH Q S
Sbjct: 1391 EEAKKKLLKDAEALSQRLEEKALAYDKLEKTKN------RLQQELDDLTVDLDHQRQVAS 1444
Query: 395 FLHPSYYLYMCDKVVAPNVSLTSAVSQSKELTKTEASKSISRQSEKAHSSGKLQKTVSYP 454
L + D+++A S+++ ++ ++ + EA + + KA S + +
Sbjct: 1445 NLEKKQKKF--DQLLAEEKSISARYAEERDRAEAEARE----KETKALSLARALEEALEA 1498
Query: 455 DVSLEEQEKMDLKTSRELCSRLD---ASISNNSTSKRKSESATCNLVRDINKVGIGLVAA 511
E Q K +L S D ++ SKR E + + ++ L A
Sbjct: 1499 KEEFERQNKQLRADMEDLMSSKDDVGKNVHELEKSKRALEQQVEEMRTQLEELEDELQAT 1558
Query: 512 ASSPLLVKDVICEDDKGKIMEEVMRTYLKQQEKLNLILQKKQQLQMEVKMLSSSKSM--- 568
+ L + +V + K + ++ + +EK L++++ ++L+ E++ +++
Sbjct: 1559 EDAKLRL-EVNMQAMKAQFERDLQTRDEQNEEKKRLLIKQVRELEAELEDERKQRALAVA 1617
Query: 569 --KELTEEQQNLQKELESL---QNEHAQRMEEFYVEQKDLEKKLEQIMKQKCTCDSNLEK 623
K++ + ++L+ ++E+ ++E +++ + + KD +++LE+ + D +
Sbjct: 1618 SKKKMEIDLKDLEAQIEAANKARDEVIKQLRKLQAQMKDYQRELEEARASR---DEIFAQ 1674
Query: 624 DKEAEYAGQLAELRQRLDHAEADRQELQDELRQEREARQKLEMMIKELKLQILKSS 679
KE+E ++L EA+ +LQ+EL AR+ E EL +I S+
Sbjct: 1675 SKESE---------KKLKSLEAEILQLQEELASSERARRHAEQERDELADEITNSA 1721
Score = 47.8 bits (112), Expect = 3e-05
Identities = 52/238 (21%), Positives = 107/238 (44%), Gaps = 25/238 (10%)
Query: 429 EASKSISRQSEKAHSSGKLQKTVSYPDVSLEEQEKMDLKTSRELCSRLDASISNNSTSKR 488
E S ++ + EKA + K++ LEE+ K + KT +EL +KR
Sbjct: 1010 ECSSQLAEEEEKAKNLAKIRNKQEVMISDLEERLKKEEKTRQEL-----------EKAKR 1058
Query: 489 KSESATCNLVRDINKVGIGLVAAASSPLLVKDVICEDDKGKIMEEVMRTYLKQQEKLNLI 548
K + T +L I + + A L ++ E++ + L + L ++
Sbjct: 1059 KLDGETTDLQDQIAE-----LQAQIDELKLQLAKKEEELQGALARGDDETLHKNNALKVV 1113
Query: 549 LQKKQQLQMEVKMLSSSKSMKELTEEQ-QNLQKELESLQNEHAQRMEEFYVEQKDLEKKL 607
+ + Q+ + S K+ + E+Q ++L +ELE+L+ E ++ +Q+ K+
Sbjct: 1114 RELQAQIAELQEDFESEKASRNKAEKQKRDLSEELEALKTELEDTLDTTAAQQELRTKRE 1173
Query: 608 EQIMKQKCTCDSNLEKDKEAEYAGQLAELRQRLDHAEADRQELQDELRQEREARQKLE 665
+++ + K + ++ + Q+ ++RQR HA A +EL ++L Q + + LE
Sbjct: 1174 QEVAELKKALE-----EETKNHEAQIQDMRQR--HATA-LEELSEQLEQAKRFKANLE 1223
Score = 43.5 bits (101), Expect = 6e-04
Identities = 41/168 (24%), Positives = 79/168 (47%), Gaps = 18/168 (10%)
Query: 529 KIMEEVMRTYLKQQE--------KLNLILQKKQQLQMEVKMLSSSKSMKELTEEQQNLQK 580
K+++ YLK + K+ +LQ +Q E ++ + + + ++ E+Q ++
Sbjct: 817 KVLQRNCAAYLKLRHWQWWRVFTKVKPLLQVTRQ---EEELQAKDEELLKVKEKQTKVEG 873
Query: 581 ELESLQNEHAQRMEEFYVEQKDLEKKLEQIMKQKCTCDSNLEKDKEAEYAGQLAELRQRL 640
ELE ++ +H Q +EE + + L+ + E + + K +E E L +L R+
Sbjct: 874 ELEEMERKHQQLLEEKNILAEQLQAETELFAEAEEMRARLAAKKQELEEI--LHDLESRV 931
Query: 641 DHAEADRQELQDELRQEREARQKLEMMIKE-----LKLQILKSSKTAK 683
+ E Q LQ+E ++ + Q LE + E KLQ+ K + AK
Sbjct: 932 EEEEERNQILQNEKKKMQAHIQDLEEQLDEEEGARQKLQLEKVTAEAK 979
Score = 42.0 bits (97), Expect = 0.002
Identities = 58/262 (22%), Positives = 118/262 (45%), Gaps = 24/262 (9%)
Query: 424 ELTKTEASK---SISRQSEKAHSSGKLQKTVSYPDVSLEEQEKMDLKTSRELCSRLDASI 480
EL TE +K ++ Q+ KA LQ D EE++++ +K REL + L+
Sbjct: 1554 ELQATEDAKLRLEVNMQAMKAQFERDLQTR----DEQNEEKKRLLIKQVRELEAELEDER 1609
Query: 481 SNNS---TSKRKSESATCNLVRDI---NKVGIGLVAAASS-PLLVKDVICEDDKGKIMEE 533
+ SK+K E +L I NK ++ +KD E ++ + +
Sbjct: 1610 KQRALAVASKKKMEIDLKDLEAQIEAANKARDEVIKQLRKLQAQMKDYQRELEEARASRD 1669
Query: 534 VMRTYLKQQEKLNLILQKKQQLQMEVKMLSSSKSMKELTEEQQNLQKELESLQNEHAQRM 593
+ K+ EK L + + LQ++ ++ SS ++ + +E+ L E+ + + + +
Sbjct: 1670 EIFAQSKESEK-KLKSLEAEILQLQEELASSERARRHAEQERDELADEITNSASGKSALL 1728
Query: 594 EEFYVEQKDLEKKLEQIMKQKCTCDSNLEKDKEAEYAGQLAELRQRLDHAEADRQELQDE 653
+E ++ LE ++ Q+ ++ SN+E + + + ++D A+ +
Sbjct: 1729 DE----KRRLEARIAQLEEELEEEQSNMELLND-----RFRKTTLQVDTLNAELAAERSA 1779
Query: 654 LRQEREARQKLEMMIKELKLQI 675
++ ARQ+LE KELK ++
Sbjct: 1780 AQKSDNARQQLERQNKELKAKL 1801
Score = 41.6 bits (96), Expect = 0.002
Identities = 48/180 (26%), Positives = 89/180 (49%), Gaps = 31/180 (17%)
Query: 527 KGKIMEEVMR---TYLKQQEKLNLILQ-KKQQLQMEVKMLSSSKSMKELTEEQQNLQK-E 581
K + +EE++ + ++++E+ N ILQ +K+++Q ++ L ++L EE+ QK +
Sbjct: 916 KKQELEEILHDLESRVEEEEERNQILQNEKKKMQAHIQDLE-----EQLDEEEGARQKLQ 970
Query: 582 LESLQNE-HAQRMEEFYVEQKDL------EKKLEQIMKQKCTCDSNLEKDKEAEYAG--- 631
LE + E ++MEE + +D EKKL + +C+ E++K A
Sbjct: 971 LEKVTAEAKIKKMEEEILLLEDQNSKFIKEKKLMEDRIAECSSQLAEEEEKAKNLAKIRN 1030
Query: 632 ----QLAELRQRLDHAEADRQELQ-------DELRQEREARQKLEMMIKELKLQILKSSK 680
+++L +RL E RQEL+ E ++ +L+ I ELKLQ+ K +
Sbjct: 1031 KQEVMISDLEERLKKEEKTRQELEKAKRKLDGETTDLQDQIAELQAQIDELKLQLAKKEE 1090
Score = 41.2 bits (95), Expect = 0.003
Identities = 40/159 (25%), Positives = 81/159 (50%), Gaps = 21/159 (13%)
Query: 540 KQQEKLN-----LILQKKQQLQMEVKMLSSSKSMKELTEEQQNLQKELESLQNEHAQRME 594
+Q+E+L L+ K++Q ++E ++ + ++L EE+ L ++L++ + E E
Sbjct: 849 RQEEELQAKDEELLKVKEKQTKVEGELEEMERKHQQLLEEKNILAEQLQA-ETELFAEAE 907
Query: 595 EFYVEQKDLEKKLEQIMKQKCTCDSNLEKDKEAEYAGQ---------LAELRQRLDHAEA 645
E +++LE+I+ +S +E+++E Q + +L ++LD E
Sbjct: 908 EMRARLAAKKQELEEILHD---LESRVEEEEERNQILQNEKKKMQAHIQDLEEQLDEEEG 964
Query: 646 DRQELQDELRQEREARQKLEMMIKELKLQILKSSKTAKE 684
RQ+LQ E + A K++ M +E+ L ++SK KE
Sbjct: 965 ARQKLQLE---KVTAEAKIKKMEEEILLLEDQNSKFIKE 1000
>gi|50897852 coiled-coil domain containing 88A isoform 2 [Homo
sapiens]
Length = 1843
Score = 58.5 bits (140), Expect = 2e-08
Identities = 73/325 (22%), Positives = 139/325 (42%), Gaps = 66/325 (20%)
Query: 406 DKVVAPNVSLTSAVSQSKELTKTEASKSISRQSEKAHSSGKLQKTVSYPDVSLEEQEKMD 465
+++V SL + + SK+L K +A +L+KT+ +L E +
Sbjct: 512 NEIVQEKQSLQNCQNLSKDLMKEKA---------------QLEKTIE----TLRENSERQ 552
Query: 466 LKTSRELCSRLDASISNNSTSKRKSESATCNLVRDINKVGIGLVAAASSPL--------- 516
+K + L+ ++S+ + S A + NK+ + SS L
Sbjct: 553 IKILEQENEHLNQTVSSLRQRSQISAEARVKDIEKENKILHESIKETSSKLSKIEFEKRQ 612
Query: 517 LVKDVICEDDKGKIMEEVMRTYLKQQEKLNLILQKK-----------QQLQMEVKMLS-S 564
+ K++ +KG+ EE + L EK N +LQKK + L+ E L
Sbjct: 613 IKKELEHYKEKGERAEE-LENELHHLEKENELLQKKITNLKITCEKIEALEQENSELERE 671
Query: 565 SKSMKELTEEQQNLQKELESLQNEHAQ--------------------RMEEFYVEQKDLE 604
++ +K+ + +NL +LESL+ E++Q +M + +E K+LE
Sbjct: 672 NRKLKKTLDSFKNLTFQLESLEKENSQLDEENLELRRNVESLKCASMKMAQLQLENKELE 731
Query: 605 KKLEQIMKQKCTCDSNLEKDK--EAEYAG---QLAELRQRLDHAEADRQELQDELRQERE 659
+ EQ+ K ++ +K + E Y G + L++ L+++ Q+L+ EL+
Sbjct: 732 SEKEQLKKGLELLKASFKKTERLEVSYQGLDIENQRLQKTLENSNKKIQQLESELQDLEM 791
Query: 660 ARQKLEMMIKELKLQILKSSKTAKE 684
Q L+ ++ELK+ + + KE
Sbjct: 792 ENQTLQKNLEELKISSKRLEQLEKE 816
Score = 38.9 bits (89), Expect = 0.016
Identities = 55/270 (20%), Positives = 116/270 (42%), Gaps = 44/270 (16%)
Query: 421 QSKELTKTEASKSISRQSEKAHSSGKLQKTVSYPDVSLEEQEKMDLKTSRELCSRLDASI 480
+ K + + +SR E+ H + V L+E ++ L+T L +L+ +
Sbjct: 316 REKAVRVDKLESEVSRYKERLHDIEFYKARVE----ELKEDNQVLLETKTMLEDQLEGT- 370
Query: 481 SNNSTSKRKSESATCNLVRDINKVGIGLVAAASSPLLVKDVICEDDKGKI---MEEVMRT 537
A + + ++ K + L A + +D+ D+ KI MEE M
Sbjct: 371 -----------RARSDKLHELEKENLQLKAKLHDMEMERDM----DRKKIEELMEENMTL 415
Query: 538 YLKQQEKLNLILQKKQQLQMEVKMLSSSKSMKELTEEQQNLQKELESLQNEHAQRMEEFY 597
+ Q++ ++ L L E++ +S + + E Q++L E+ L + ++E
Sbjct: 416 EMAQKQSMDESLH----LGWELEQISRTSELSEAP--QKSLGHEVNELTSSRLLKLE--- 466
Query: 598 VEQKDLEKKLEQIMKQKCTCDSNLEKDKEAEYAGQLAELRQRLDHAEADRQELQDELRQE 657
+E + L K +E++ + + N K + E Q + + L++E+ QE
Sbjct: 467 MENQSLTKTVEELRTTVDSVEGNASKILKMEKENQRLSKKVEI---------LENEIVQE 517
Query: 658 REARQKLEMMIKEL---KLQILKSSKTAKE 684
+++ Q + + K+L K Q+ K+ +T +E
Sbjct: 518 KQSLQNCQNLSKDLMKEKAQLEKTIETLRE 547
Score = 37.0 bits (84), Expect = 0.061
Identities = 57/266 (21%), Positives = 115/266 (43%), Gaps = 28/266 (10%)
Query: 427 KTEASKSISRQSEKA-------HSSGKLQKTVSYPDVSLEEQ------EKMDLKTS-REL 472
+ E S++I SE+ H+S Q P + E E D K R L
Sbjct: 204 RDEHSETIIELSEERDGLHFLPHASSSAQSPCGSPGMKRTESRQHLSVELADAKAKIRRL 263
Query: 473 CSRLDASISNNSTSKRKSESATCNLVRDINKVGIGLVAAASSPLLVKDVI-CEDDKG--- 528
L+ K++ E L R + + + L++ A S + +D + +K
Sbjct: 264 RQELEEKTEQLLDCKQELEQMEIELKR-LQQENMNLLSDARSARMYRDELDALREKAVRV 322
Query: 529 -KIMEEVMRTYLKQQEKLNLILQKKQQLQMEVKMLSSSKSMKELTEEQQNLQKE-LESLQ 586
K+ EV R Y ++ + + ++L+ + ++L +K+M E E + + L L+
Sbjct: 323 DKLESEVSR-YKERLHDIEFYKARVEELKEDNQVLLETKTMLEDQLEGTRARSDKLHELE 381
Query: 587 NEHAQ---RMEEFYVEQKDLEKKLEQIMKQKCTCD--SNLEKDKEAEYAGQLAELRQRLD 641
E+ Q ++ + +E+ KK+E++M++ T + D+ +L ++ + +
Sbjct: 382 KENLQLKAKLHDMEMERDMDRKKIEELMEENMTLEMAQKQSMDESLHLGWELEQISRTSE 441
Query: 642 HAEADRQELQDELRQEREAR-QKLEM 666
+EA ++ L E+ + +R KLEM
Sbjct: 442 LSEAPQKSLGHEVNELTSSRLLKLEM 467
Score = 37.0 bits (84), Expect = 0.061
Identities = 77/366 (21%), Positives = 151/366 (41%), Gaps = 52/366 (14%)
Query: 341 EKKLKIILEEMKE---KFSMRSGKRNQSKTDAPSGMELQSWYPVIKQEGDHVSQTHSFLH 397
EK+ KI+ E +KE K S ++ Q K + E ++ E H+ + + L
Sbjct: 586 EKENKILHESIKETSSKLSKIEFEKRQIKKELEHYKEKGERAEELENELHHLEKENELLQ 645
Query: 398 PSY--YLYMCDKVVAPNVSLTSAVSQSKELTKT-EASKSISRQSEKAHSSGKLQKTVSYP 454
C+K+ A + ++++L KT ++ K+++ Q E L+K S
Sbjct: 646 KKITNLKITCEKIEALEQENSELERENRKLKKTLDSFKNLTFQLES------LEKENSQL 699
Query: 455 DVSLEEQEKMDLKTSRELCSRLDASISNNSTSKRKSESATCNLVRDINKVGIGLVAAASS 514
D +E ++L+ + E ++ ++ ES L K G+ L+ A+
Sbjct: 700 D-----EENLELRRNVESLKCASMKMAQLQLENKELESEKEQL-----KKGLELLKASFK 749
Query: 515 PLLVKDV--------------ICEDDKGKI---------MEEVMRTYLKQQEKLNLILQK 551
+V E+ KI +E +T K E+L + ++
Sbjct: 750 KTERLEVSYQGLDIENQRLQKTLENSNKKIQQLESELQDLEMENQTLQKNLEELKISSKR 809
Query: 552 KQQLQMEVKMLSSSKSMKELTEEQQNLQKELESLQNEHAQR---MEEFYVEQKDLEKKLE 608
+QL+ E K L S +L ++++ L+KE + L+ + + +EE V+ +LEK+ +
Sbjct: 810 LEQLEKENKSLEQETS--QLEKDKKQLEKENKRLRQQAEIKDTTLEENNVKIGNLEKENK 867
Query: 609 QIMKQKCTCDSNLEKDKEAEYAGQLAELRQRLD--HAEADRQELQDELRQEREARQKLEM 666
+ K+ + + KE E + R +D R++L E + ++ LE
Sbjct: 868 TLSKEIGIYKESCVRLKELEKENKELVKRATIDIKTLVTLREDLVSEKLKTQQMNNDLEK 927
Query: 667 MIKELK 672
+ EL+
Sbjct: 928 LTHELE 933
Score = 35.8 bits (81), Expect = 0.13
Identities = 65/327 (19%), Positives = 129/327 (39%), Gaps = 63/327 (19%)
Query: 406 DKVVAPNVSLTSAVSQSKELTKTEASKSISRQSEKAHSSGKLQKTV-SYPDVSLEEQ--E 462
+K+ A L + + +++L + K++ + E ++ V S P +S E+ E
Sbjct: 974 EKIAALEARLEESTNYNQQLR--QELKTVKKNYEALKQRQDEERMVQSSPPISGEDNKWE 1031
Query: 463 KMDLKTSRELCSRLDASIS---NNSTSKRKSESATCNL-------------VRDINKVGI 506
+ +T+REL D I NN+T + + ++ L + + + +
Sbjct: 1032 RESQETTRELLKVKDRLIEVERNNATLQAEKQALKTQLKQLETQNNNLQAQILALQRQTV 1091
Query: 507 GL------VAAASSPLLVKDVICEDDKGKIMEEVMRTYLKQQEKLN---LILQKKQQLQM 557
L + ++ L V++ +M + + ++Q N ++++++ L+
Sbjct: 1092 SLQEQNTTLQTQNAKLQVENSTLNSQSTSLMNQNAQLLIQQSSLENENESVIKEREDLKS 1151
Query: 558 EVKMLSSSKSMKELTEEQQNLQKELESLQNEHA---QRMEEFYVEQKDLEKKLEQIMKQK 614
L EL E+Q E ESL ++H + VE +DLE + Q++KQK
Sbjct: 1152 LYDSLIKDHEKLELLHERQ--ASEYESLISKHGTLKSAHKNLEVEHRDLEDRYNQLLKQK 1209
Query: 615 CTCDSNLEKDKEAEYAGQLAELR----------------QRLDHA-----------EADR 647
+ +LEK + E L E + RL+H + D
Sbjct: 1210 GQLE-DLEKMLKVEQEKMLLENKNHETVAAEYKKLCGENDRLNHTYSQLLKETEVLQTDH 1268
Query: 648 QELQDELRQEREARQKLEMMIKELKLQ 674
+ L+ L + + +LE +LK Q
Sbjct: 1269 KNLKSLLNNSKLEQTRLEAEFSKLKEQ 1295
Score = 30.4 bits (67), Expect = 5.7
Identities = 57/272 (20%), Positives = 114/272 (41%), Gaps = 42/272 (15%)
Query: 424 ELTKTEASKSISRQSEKAHSSGKLQKTVSYPDVS---LEE--QEKMDL----KTSRELCS 474
E T+ + K + E KL D+ +EE +E M L K S +
Sbjct: 368 EGTRARSDKLHELEKENLQLKAKLHDMEMERDMDRKKIEELMEENMTLEMAQKQSMDESL 427
Query: 475 RLDASISNNSTSKRKSESATCNLVRDINKVGIGLVAAASSPLLVKDVICEDDKGKIMEEV 534
L + S + SE+ +L ++N++ +S L+K + K +EE+
Sbjct: 428 HLGWELEQISRTSELSEAPQKSLGHEVNEL--------TSSRLLKLEMENQSLTKTVEEL 479
Query: 535 MRTYLKQQEKLNLILQ---KKQQLQMEVKMLSSSKSMKELTEEQQNLQKELESLQNEHAQ 591
T + + IL+ + Q+L +V++L + E+ +E+Q+L ++ QN
Sbjct: 480 RTTVDSVEGNASKILKMEKENQRLSKKVEILEN-----EIVQEKQSL----QNCQNLSKD 530
Query: 592 RMEEFYVEQKDLEKKLEQIMKQKCTCDSNLEKDKEAEYAGQLAELRQ--------RLDHA 643
M+ E+ LEK +E + + LE++ E ++ LRQ R+
Sbjct: 531 LMK----EKAQLEKTIETLRENSERQIKILEQENE-HLNQTVSSLRQRSQISAEARVKDI 585
Query: 644 EADRQELQDELRQEREARQKLEMMIKELKLQI 675
E + + L + +++ K+E +++K ++
Sbjct: 586 EKENKILHESIKETSSKLSKIEFEKRQIKKEL 617
Score = 29.6 bits (65), Expect = 9.7
Identities = 29/128 (22%), Positives = 59/128 (46%), Gaps = 11/128 (8%)
Query: 564 SSKSMKELTEEQQNLQKELESLQNEHAQRMEEFYVEQKDLEKKLEQIMKQKCTCDSNLEK 623
S + ++ L + K L ++EH++ + E E+ L + C S K
Sbjct: 182 SQEDIEPLLKNMALHLKRLIDERDEHSETIIELSEERDGLHFLPHASSSAQSPCGSPGMK 241
Query: 624 DKEAEY--AGQLAELRQRLDHAEADRQELQDELRQEREARQKLEMMIKELK------LQI 675
E+ + +LA+ + ++ RQEL+++ Q + +Q+LE M ELK + +
Sbjct: 242 RTESRQHLSVELADAKAKIRRL---RQELEEKTEQLLDCKQELEQMEIELKRLQQENMNL 298
Query: 676 LKSSKTAK 683
L +++A+
Sbjct: 299 LSDARSAR 306
>gi|208022632 coiled-coil domain containing 88A isoform 1 [Homo
sapiens]
Length = 1870
Score = 58.5 bits (140), Expect = 2e-08
Identities = 73/325 (22%), Positives = 139/325 (42%), Gaps = 66/325 (20%)
Query: 406 DKVVAPNVSLTSAVSQSKELTKTEASKSISRQSEKAHSSGKLQKTVSYPDVSLEEQEKMD 465
+++V SL + + SK+L K +A +L+KT+ +L E +
Sbjct: 512 NEIVQEKQSLQNCQNLSKDLMKEKA---------------QLEKTIE----TLRENSERQ 552
Query: 466 LKTSRELCSRLDASISNNSTSKRKSESATCNLVRDINKVGIGLVAAASSPL--------- 516
+K + L+ ++S+ + S A + NK+ + SS L
Sbjct: 553 IKILEQENEHLNQTVSSLRQRSQISAEARVKDIEKENKILHESIKETSSKLSKIEFEKRQ 612
Query: 517 LVKDVICEDDKGKIMEEVMRTYLKQQEKLNLILQKK-----------QQLQMEVKMLS-S 564
+ K++ +KG+ EE + L EK N +LQKK + L+ E L
Sbjct: 613 IKKELEHYKEKGERAEE-LENELHHLEKENELLQKKITNLKITCEKIEALEQENSELERE 671
Query: 565 SKSMKELTEEQQNLQKELESLQNEHAQ--------------------RMEEFYVEQKDLE 604
++ +K+ + +NL +LESL+ E++Q +M + +E K+LE
Sbjct: 672 NRKLKKTLDSFKNLTFQLESLEKENSQLDEENLELRRNVESLKCASMKMAQLQLENKELE 731
Query: 605 KKLEQIMKQKCTCDSNLEKDK--EAEYAG---QLAELRQRLDHAEADRQELQDELRQERE 659
+ EQ+ K ++ +K + E Y G + L++ L+++ Q+L+ EL+
Sbjct: 732 SEKEQLKKGLELLKASFKKTERLEVSYQGLDIENQRLQKTLENSNKKIQQLESELQDLEM 791
Query: 660 ARQKLEMMIKELKLQILKSSKTAKE 684
Q L+ ++ELK+ + + KE
Sbjct: 792 ENQTLQKNLEELKISSKRLEQLEKE 816
Score = 47.4 bits (111), Expect = 4e-05
Identities = 86/395 (21%), Positives = 158/395 (40%), Gaps = 57/395 (14%)
Query: 341 EKKLKIILEEMKE---KFSMRSGKRNQSKTDAPSGMELQSWYPVIKQEGDHVSQTHSFLH 397
EK+ KI+ E +KE K S ++ Q K + E ++ E H+ + + L
Sbjct: 586 EKENKILHESIKETSSKLSKIEFEKRQIKKELEHYKEKGERAEELENELHHLEKENELLQ 645
Query: 398 PSY--YLYMCDKVVAPNVSLTSAVSQSKELTKT-EASKSISRQSEKAHSSG--------K 446
C+K+ A + ++++L KT ++ K+++ Q E +
Sbjct: 646 KKITNLKITCEKIEALEQENSELERENRKLKKTLDSFKNLTFQLESLEKENSQLDEENLE 705
Query: 447 LQKTVS--------YPDVSLE----EQEKMDLKTSRELCS-------RLDASISNNSTSK 487
L++ V + LE E EK LK EL RL+ S
Sbjct: 706 LRRNVESLKCASMKMAQLQLENKELESEKEQLKKGLELLKASFKKTERLEVSYQGLDIEN 765
Query: 488 RKSESATCNLVRDINKVGIGLV-AAASSPLLVKDVICEDDKGKIMEEVMRTYLKQQEKLN 546
++ + N + I ++ L + L K++ K +E++ + +++ +
Sbjct: 766 QRLQKTLENSNKKIQQLESELQDLEMENQTLQKNLEELKISSKRLEQLEKENKSLEQETS 825
Query: 547 LILQKKQQLQMEVKMLSSSKSMKELTEEQQN-----LQKELESLQNE------HAQRMEE 595
+ + K+QL+ E K L +K+ T E+ N L+KE ++L E R++E
Sbjct: 826 QLEKDKKQLEKENKRLRQQAEIKDTTLEENNVKIGNLEKENKTLSKEIGIYKESCVRLKE 885
Query: 596 FYVEQKDLEKKLEQIMKQKCTCDSNL--EKDKEAEYAGQLAEL----------RQRLDHA 643
E K+L K+ +K T +L EK K + L +L ++RL H
Sbjct: 886 LEKENKELVKRATIDIKTLVTLREDLVSEKLKTQQMNNDLEKLTHELEKIGLNKERLLHD 945
Query: 644 EADRQELQDELRQEREARQKLEMMIKELKLQILKS 678
E + L + E+ K + IKE K+ L++
Sbjct: 946 EQSTDDRYKLLESKLESTLKKSLEIKEEKIAALEA 980
Score = 38.9 bits (89), Expect = 0.016
Identities = 55/270 (20%), Positives = 116/270 (42%), Gaps = 44/270 (16%)
Query: 421 QSKELTKTEASKSISRQSEKAHSSGKLQKTVSYPDVSLEEQEKMDLKTSRELCSRLDASI 480
+ K + + +SR E+ H + V L+E ++ L+T L +L+ +
Sbjct: 316 REKAVRVDKLESEVSRYKERLHDIEFYKARVE----ELKEDNQVLLETKTMLEDQLEGT- 370
Query: 481 SNNSTSKRKSESATCNLVRDINKVGIGLVAAASSPLLVKDVICEDDKGKI---MEEVMRT 537
A + + ++ K + L A + +D+ D+ KI MEE M
Sbjct: 371 -----------RARSDKLHELEKENLQLKAKLHDMEMERDM----DRKKIEELMEENMTL 415
Query: 538 YLKQQEKLNLILQKKQQLQMEVKMLSSSKSMKELTEEQQNLQKELESLQNEHAQRMEEFY 597
+ Q++ ++ L L E++ +S + + E Q++L E+ L + ++E
Sbjct: 416 EMAQKQSMDESLH----LGWELEQISRTSELSEAP--QKSLGHEVNELTSSRLLKLE--- 466
Query: 598 VEQKDLEKKLEQIMKQKCTCDSNLEKDKEAEYAGQLAELRQRLDHAEADRQELQDELRQE 657
+E + L K +E++ + + N K + E Q + + L++E+ QE
Sbjct: 467 MENQSLTKTVEELRTTVDSVEGNASKILKMEKENQRLSKKVEI---------LENEIVQE 517
Query: 658 REARQKLEMMIKEL---KLQILKSSKTAKE 684
+++ Q + + K+L K Q+ K+ +T +E
Sbjct: 518 KQSLQNCQNLSKDLMKEKAQLEKTIETLRE 547
Score = 37.0 bits (84), Expect = 0.061
Identities = 57/266 (21%), Positives = 115/266 (43%), Gaps = 28/266 (10%)
Query: 427 KTEASKSISRQSEKA-------HSSGKLQKTVSYPDVSLEEQ------EKMDLKTS-REL 472
+ E S++I SE+ H+S Q P + E E D K R L
Sbjct: 204 RDEHSETIIELSEERDGLHFLPHASSSAQSPCGSPGMKRTESRQHLSVELADAKAKIRRL 263
Query: 473 CSRLDASISNNSTSKRKSESATCNLVRDINKVGIGLVAAASSPLLVKDVI-CEDDKG--- 528
L+ K++ E L R + + + L++ A S + +D + +K
Sbjct: 264 RQELEEKTEQLLDCKQELEQMEIELKR-LQQENMNLLSDARSARMYRDELDALREKAVRV 322
Query: 529 -KIMEEVMRTYLKQQEKLNLILQKKQQLQMEVKMLSSSKSMKELTEEQQNLQKE-LESLQ 586
K+ EV R Y ++ + + ++L+ + ++L +K+M E E + + L L+
Sbjct: 323 DKLESEVSR-YKERLHDIEFYKARVEELKEDNQVLLETKTMLEDQLEGTRARSDKLHELE 381
Query: 587 NEHAQ---RMEEFYVEQKDLEKKLEQIMKQKCTCD--SNLEKDKEAEYAGQLAELRQRLD 641
E+ Q ++ + +E+ KK+E++M++ T + D+ +L ++ + +
Sbjct: 382 KENLQLKAKLHDMEMERDMDRKKIEELMEENMTLEMAQKQSMDESLHLGWELEQISRTSE 441
Query: 642 HAEADRQELQDELRQEREAR-QKLEM 666
+EA ++ L E+ + +R KLEM
Sbjct: 442 LSEAPQKSLGHEVNELTSSRLLKLEM 467
Score = 35.8 bits (81), Expect = 0.13
Identities = 65/327 (19%), Positives = 129/327 (39%), Gaps = 63/327 (19%)
Query: 406 DKVVAPNVSLTSAVSQSKELTKTEASKSISRQSEKAHSSGKLQKTV-SYPDVSLEEQ--E 462
+K+ A L + + +++L + K++ + E ++ V S P +S E+ E
Sbjct: 973 EKIAALEARLEESTNYNQQLR--QELKTVKKNYEALKQRQDEERMVQSSPPISGEDNKWE 1030
Query: 463 KMDLKTSRELCSRLDASIS---NNSTSKRKSESATCNL-------------VRDINKVGI 506
+ +T+REL D I NN+T + + ++ L + + + +
Sbjct: 1031 RESQETTRELLKVKDRLIEVERNNATLQAEKQALKTQLKQLETQNNNLQAQILALQRQTV 1090
Query: 507 GL------VAAASSPLLVKDVICEDDKGKIMEEVMRTYLKQQEKLN---LILQKKQQLQM 557
L + ++ L V++ +M + + ++Q N ++++++ L+
Sbjct: 1091 SLQEQNTTLQTQNAKLQVENSTLNSQSTSLMNQNAQLLIQQSSLENENESVIKEREDLKS 1150
Query: 558 EVKMLSSSKSMKELTEEQQNLQKELESLQNEHA---QRMEEFYVEQKDLEKKLEQIMKQK 614
L EL E+Q E ESL ++H + VE +DLE + Q++KQK
Sbjct: 1151 LYDSLIKDHEKLELLHERQ--ASEYESLISKHGTLKSAHKNLEVEHRDLEDRYNQLLKQK 1208
Query: 615 CTCDSNLEKDKEAEYAGQLAELR----------------QRLDHA-----------EADR 647
+ +LEK + E L E + RL+H + D
Sbjct: 1209 GQLE-DLEKMLKVEQEKMLLENKNHETVAAEYKKLCGENDRLNHTYSQLLKETEVLQTDH 1267
Query: 648 QELQDELRQEREARQKLEMMIKELKLQ 674
+ L+ L + + +LE +LK Q
Sbjct: 1268 KNLKSLLNNSKLEQTRLEAEFSKLKEQ 1294
Score = 30.4 bits (67), Expect = 5.7
Identities = 57/272 (20%), Positives = 114/272 (41%), Gaps = 42/272 (15%)
Query: 424 ELTKTEASKSISRQSEKAHSSGKLQKTVSYPDVS---LEE--QEKMDL----KTSRELCS 474
E T+ + K + E KL D+ +EE +E M L K S +
Sbjct: 368 EGTRARSDKLHELEKENLQLKAKLHDMEMERDMDRKKIEELMEENMTLEMAQKQSMDESL 427
Query: 475 RLDASISNNSTSKRKSESATCNLVRDINKVGIGLVAAASSPLLVKDVICEDDKGKIMEEV 534
L + S + SE+ +L ++N++ +S L+K + K +EE+
Sbjct: 428 HLGWELEQISRTSELSEAPQKSLGHEVNEL--------TSSRLLKLEMENQSLTKTVEEL 479
Query: 535 MRTYLKQQEKLNLILQ---KKQQLQMEVKMLSSSKSMKELTEEQQNLQKELESLQNEHAQ 591
T + + IL+ + Q+L +V++L + E+ +E+Q+L ++ QN
Sbjct: 480 RTTVDSVEGNASKILKMEKENQRLSKKVEILEN-----EIVQEKQSL----QNCQNLSKD 530
Query: 592 RMEEFYVEQKDLEKKLEQIMKQKCTCDSNLEKDKEAEYAGQLAELRQ--------RLDHA 643
M+ E+ LEK +E + + LE++ E ++ LRQ R+
Sbjct: 531 LMK----EKAQLEKTIETLRENSERQIKILEQENE-HLNQTVSSLRQRSQISAEARVKDI 585
Query: 644 EADRQELQDELRQEREARQKLEMMIKELKLQI 675
E + + L + +++ K+E +++K ++
Sbjct: 586 EKENKILHESIKETSSKLSKIEFEKRQIKKEL 617
Score = 29.6 bits (65), Expect = 9.7
Identities = 29/128 (22%), Positives = 59/128 (46%), Gaps = 11/128 (8%)
Query: 564 SSKSMKELTEEQQNLQKELESLQNEHAQRMEEFYVEQKDLEKKLEQIMKQKCTCDSNLEK 623
S + ++ L + K L ++EH++ + E E+ L + C S K
Sbjct: 182 SQEDIEPLLKNMALHLKRLIDERDEHSETIIELSEERDGLHFLPHASSSAQSPCGSPGMK 241
Query: 624 DKEAEY--AGQLAELRQRLDHAEADRQELQDELRQEREARQKLEMMIKELK------LQI 675
E+ + +LA+ + ++ RQEL+++ Q + +Q+LE M ELK + +
Sbjct: 242 RTESRQHLSVELADAKAKIRRL---RQELEEKTEQLLDCKQELEQMEIELKRLQQENMNL 298
Query: 676 LKSSKTAK 683
L +++A+
Sbjct: 299 LSDARSAR 306
>gi|41322923 plectin 1 isoform 11 [Homo sapiens]
Length = 4547
Score = 56.6 bits (135), Expect = 7e-08
Identities = 59/270 (21%), Positives = 123/270 (45%), Gaps = 29/270 (10%)
Query: 419 VSQSKELTKTEASKSISRQSEKAHSSGKLQKTVSYPDVSLEEQEKMDLKTSRELCSRLDA 478
+ Q KEL + +A + Q +K + +L + +LE + + L+ S E RL
Sbjct: 2332 LQQQKELAQEQARRL---QEDKEQMAQQLAEETQGFQRTLEAERQRQLEMSAE-AERLKL 2387
Query: 479 SISNNSTSKRKSESATCNLVRDINKVGIGL----VAAASSPLLVKDVICEDDKGKIMEEV 534
++ S ++ ++E + ++G L +A LV+ + + + E
Sbjct: 2388 RVAEMSRAQARAEEDAQRFRKQAEEIGEKLHRTELATQEKVTLVQTLEIQRQQSDHDAER 2447
Query: 535 MRTYLKQQEKLNLILQKKQQLQMEVKMLSSSKSMKELTEEQQNLQKELESLQNEHAQRME 594
+R + + E+ +K++LQ E K+L KS + T +Q+ L +E ++LQ +
Sbjct: 2448 LREAIAELER------EKEKLQQEAKLLQL-KSEEMQTVQQEQLLQETQALQQSFLSEKD 2500
Query: 595 EFYVEQKDLEK---KLEQIMKQKCTCDSNLEKDKEAEY----------AGQLAELRQRLD 641
++ +E+ KLEQ+ + + L ++++ + + E R+R
Sbjct: 2501 SLLQRERFIEQEKAKLEQLFQDEVAKAQQLREEQQRQQQQMEQERQRLVASMEEARRRQH 2560
Query: 642 HAEADRQELQDELRQ-EREARQKLEMMIKE 670
AE + Q+EL+Q E++ RQ+ E++ +E
Sbjct: 2561 EAEEGVRRKQEELQQLEQQRRQQEELLAEE 2590
Score = 52.4 bits (124), Expect = 1e-06
Identities = 68/284 (23%), Positives = 126/284 (44%), Gaps = 34/284 (11%)
Query: 420 SQSKELTKTEASKSISRQSEKAHSSGKLQKTVSYPDVSLEEQEKM----DLKTSRELCSR 475
SQ K + E + + ++E A + + + + EE E+ +++ +R++
Sbjct: 1507 SQRKRQAEVELASRVKAEAEAAREKQRALQALEELRLQAEEAERRLRQAEVERARQVQVA 1566
Query: 476 LDA---SISNNSTSKRKS-ESATCNLVRDINK--VGIGLVAAASSPLLVKDVICEDDKGK 529
L+ S SKR S T L R + + V + + + + E + +
Sbjct: 1567 LETAQRSAEAELQSKRASFAEKTAQLERSLQEEHVAVAQLREEAERRAQQQAEAERAREE 1626
Query: 530 IMEEVMRTYLKQQEKLNLILQKKQQLQMEVKMLSSSKSMKELTEEQQNLQKELESLQNEH 589
E+ R LK E L L LQ ++ Q KS+ + E+Q + E E+ +
Sbjct: 1627 AERELERWQLKANEALRLRLQAEEVAQQ--------KSLAQAEAEKQKEEAEREARRRGK 1678
Query: 590 AQRMEEFYVEQKDLEKKLEQIMKQKCTCDSNLEKDKEAEYAGQLAELRQRLDHAEADRQE 649
A EE V Q++L + +++ KQ+ + ++ AE +L LR + E RQ
Sbjct: 1679 A---EEQAVRQRELAE--QELEKQRQLAEGTAQQRLAAEQ--ELIRLRAETEQGEQQRQL 1731
Query: 650 LQDEL-RQEREA------RQKLEMMIKELK--LQILKSSKTAKE 684
L++EL R +REA RQ+LE + +++ +++L +SK E
Sbjct: 1732 LEEELARLQREAAAATQKRQELEAELAKVRAEMEVLLASKARAE 1775
Score = 44.3 bits (103), Expect = 4e-04
Identities = 65/296 (21%), Positives = 123/296 (41%), Gaps = 43/296 (14%)
Query: 421 QSKELTKTEASKSISRQSEKAHSSGK---------LQKTVSYPDVSLEE------QEKMD 465
+ + L + EA+ RQ +AH+ K LQ+ + V EE Q+K
Sbjct: 1358 ERERLAEVEAALEKQRQLAEAHAQAKAQAEREAKELQQRMQEEVVRREEAAVDAQQQKRS 1417
Query: 466 LKTS-RELCSRLDASISNNSTSKRKSESATCNLVRDINKVGIGLVAAAS---------SP 515
++ ++L +A I + +E + + +I V + L A
Sbjct: 1418 IQEELQQLRQSSEAEIQAKARQAEAAERSRLRIEEEIRVVRLQLEATERQRGGAEGELQA 1477
Query: 516 LLVKDVICEDDKGKIMEEVMRTYLKQQEKLNLILQKKQQLQMEVKMLSSSKSMKELTEEQ 575
L + E K + EE R + Q+ + +++ Q EV++ S K+ E E+
Sbjct: 1478 LRARAEEAEAQKRQAQEEAERLRRQVQD------ESQRKRQAEVELASRVKAEAEAAREK 1531
Query: 576 QNLQKELES--LQNEHAQRMEEFYVEQKDLEKKLE-QIMKQKCTCDSNLE-KDKEAEYAG 631
Q + LE LQ E A+R + Q ++E+ + Q+ + + E + K A +A
Sbjct: 1532 QRALQALEELRLQAEEAERR----LRQAEVERARQVQVALETAQRSAEAELQSKRASFAE 1587
Query: 632 QLAELRQRLDHAEAD----RQELQDELRQEREARQKLEMMIKELKLQILKSSKTAK 683
+ A+L + L R+E + +Q+ EA + E +EL+ LK+++ +
Sbjct: 1588 KTAQLERSLQEEHVAVAQLREEAERRAQQQAEAERAREEAERELERWQLKANEALR 1643
Score = 38.1 bits (87), Expect = 0.027
Identities = 28/140 (20%), Positives = 69/140 (49%), Gaps = 6/140 (4%)
Query: 551 KKQQLQMEVKMLSSSKSMKELTEEQQNLQKELESLQNEHAQRMEEFYVEQKDLEKKLEQI 610
K+ Q +M+ +++ ++ + ++++++Q+EL+ L+ ++ + + E+ +I
Sbjct: 1391 KELQQRMQEEVVRREEAAVDAQQQKRSIQEELQQLRQSSEAEIQAKARQAEAAERSRLRI 1450
Query: 611 MKQKCTCDSNLEKDKEAEYA--GQLAELRQRLDHAEADRQELQDEL----RQEREARQKL 664
++ LE + G+L LR R + AEA +++ Q+E RQ ++ Q+
Sbjct: 1451 EEEIRVVRLQLEATERQRGGAEGELQALRARAEEAEAQKRQAQEEAERLRRQVQDESQRK 1510
Query: 665 EMMIKELKLQILKSSKTAKE 684
EL ++ ++ A+E
Sbjct: 1511 RQAEVELASRVKAEAEAARE 1530
Score = 37.7 bits (86), Expect = 0.035
Identities = 41/161 (25%), Positives = 79/161 (49%), Gaps = 13/161 (8%)
Query: 516 LLVKDVICEDDKGKIMEEVMRTYLKQQEKLNLILQKKQQLQMEVKMLSSSKSMKELTEEQ 575
LL ++ E +K K+ E++ + + + ++L Q++QQ QME + SM+E Q
Sbjct: 2502 LLQRERFIEQEKAKL-EQLFQDEVAKAQQLREEQQRQQQ-QMEQERQRLVASMEEARRRQ 2559
Query: 576 -------QNLQKELESLQNEHAQRMEEFYVEQKDLEKKLEQIMKQKCTCDSNLEKDKEAE 628
+ Q+EL+ L+ + Q+ E E + L ++L+ + +Q ++ E+ ++
Sbjct: 2560 HEAEEGVRRKQEELQQLEQQRRQQEELLAEENQRLREQLQLLEEQHRAALAHSEEVTASQ 2619
Query: 629 YAG--QLAELRQRLD--HAEADRQELQDELRQEREARQKLE 665
A L R LD AEA+ + D LR++ A++ E
Sbjct: 2620 VAATKTLPNGRDALDGPAAEAEPEHSFDGLRRKVSAQRLQE 2660
Score = 35.8 bits (81), Expect = 0.13
Identities = 54/281 (19%), Positives = 116/281 (41%), Gaps = 36/281 (12%)
Query: 416 TSAVSQSKELTKTEASKSISRQSEKAHSSGKLQKTVSYPDVSLEEQEKMDLKTSRELCSR 475
T Q ++L + E ++ Q E A ++ K Q+ + E K+ + L S+
Sbjct: 1722 TEQGEQQRQLLEEELARL---QREAAAATQKRQELEA-------ELAKVRAEMEVLLASK 1771
Query: 476 LDASISNNSTSKRKSE--SATCNLVRDINKVGIGLVAAASSPLLVKDVICEDDKGKIMEE 533
A + STS++ + A R++ + L A A + + E+D + E
Sbjct: 1772 ARAEEESRSTSEKSKQRLEAEAGRFRELAEEAARLRALAEEAKRQRQ-LAEEDAARQRAE 1830
Query: 534 VMRTYLKQQEKLNLILQKKQQLQMEVKMLSS-SKSMKELTEEQQNLQKELESLQNEHAQR 592
R ++ + + K + ++ +K + ++ ++ L E++ ++ LE +H
Sbjct: 1831 AERVLAEKLAAIGEATRLKTEAEIALKEKEAENERLRRLAEDEAFQRRRLEEQAAQH--- 1887
Query: 593 MEEFYVEQKDLEKKLEQIMKQKCTCDSNLEKDK---------EAEYAGQLAELRQRLDHA 643
+ D+E++L Q+ K DS LE+ K + ++ L+ + A
Sbjct: 1888 -------KADIEERLAQLRK---ASDSELERQKGLVEDTLRQRRQVEEEILALKASFEKA 1937
Query: 644 EADRQELQDELRQEREARQKLEMMIKELKLQILKSSKTAKE 684
A + EL+ EL + R + ++ +L+ + + A E
Sbjct: 1938 AAGKAELELELGRIRSNAEDTLRSKEQAELEAARQRQLAAE 1978
Score = 35.0 bits (79), Expect = 0.23
Identities = 81/419 (19%), Positives = 162/419 (38%), Gaps = 86/419 (20%)
Query: 333 QKYLGTPEE--KKLKIILEEMKE-KFSMRSGKRNQSKTDAPSGMELQSWYPVIKQEGDHV 389
QK L EE ++ K LEE++ K + +R + + + S +LQ ++
Sbjct: 1991 QKSLAAEEEAARQRKAALEEVERLKAKVEEARRLRERAEQESARQLQLAQEAAQKRLQAE 2050
Query: 390 SQTHSFLHPSYYLYMCDKVVAPNVSLTSAVSQSKELT-----KTEASKSISRQSEKAHSS 444
+ H+F V L + Q + + + EA++ + ++E+A
Sbjct: 2051 EKAHAFA-----------VQQKEQELQQTLQQEQSVLDQLRGEAEAARRAAEEAEEARVQ 2099
Query: 445 GKLQKTVSYPDVSLEEQEKMDLKTSRELCSRLDASISNNSTSKRKSESATCNLVRDINKV 504
+ + S V EE E++ + +R A + K + A + +
Sbjct: 2100 AEREAAQSRRQV--EEAERLKQSAEEQAQARAQAQAAAEKLRKEAEQEAARRAQAE--QA 2155
Query: 505 GIGLVAAASSPLLVKDVICED---DKGKIMEEVMRTYLKQQE---KLNLILQKKQQL--- 555
+ AA + + E K ++ +E+ L+ +E + NL+ ++ Q+L
Sbjct: 2156 ALRQKQAADAEMEKHKKFAEQTLRQKAQVEQELTTLRLQLEETDHQKNLLDEELQRLKAE 2215
Query: 556 ---------QMEVKMLSSSKSMKELTE-------------------EQQNLQKELESLQN 587
Q+E ++ S M+EL++ Q+ LQ+E E ++
Sbjct: 2216 ATEAARQRSQVEEELFSVRVQMEELSKLKARIEAENRALILRDKDNTQRFLQEEAEKMKQ 2275
Query: 588 --EHAQRMEEFYVEQKDLEKKLEQIMKQKCTCDSNLEKDK------------EAEYAGQL 633
E A R+ E L + E+ + Q+ + K+K EAE Q
Sbjct: 2276 VAEEAARLSVAAQEAARLRQLAEEDLAQQRALAEKMLKEKMQAVQEATRLKAEAELLQQQ 2335
Query: 634 AELRQ-RLDHAEADRQELQDELRQ---------EREARQKLEMM--IKELKLQILKSSK 680
EL Q + + D++++ +L + E E +++LEM + LKL++ + S+
Sbjct: 2336 KELAQEQARRLQEDKEQMAQQLAEETQGFQRTLEAERQRQLEMSAEAERLKLRVAEMSR 2394
Score = 32.0 bits (71), Expect = 1.9
Identities = 34/158 (21%), Positives = 73/158 (46%), Gaps = 24/158 (15%)
Query: 532 EEVMRTY---LKQQEKLNLILQKKQQLQMEVKMLSSSKSMKE-----LTEEQQNLQKELE 583
EEV+R + LK+ + + L + + + +K L + ++ L +E + Q+ E
Sbjct: 1102 EEVLRAHEEQLKEAQAVPATLPELEATKASLKKLRAQAEAQQPTFDALRDELRGAQEVGE 1161
Query: 584 SLQNEHAQR---MEEFYVEQKDLEKKLEQIMKQKCTCDSNLEK-DKEAEYAGQ------- 632
LQ H +R +E + L ++ + ++ Q LE+ ++ Y +
Sbjct: 1162 RLQQRHGERDVEVERWRERVAQLLERWQAVLAQTDVRQRELEQLGRQLRYYRESADPLGA 1221
Query: 633 -LAELRQRLDHAEA----DRQELQDELRQEREARQKLE 665
L + R+R + +A D Q ++++LRQE+ +++E
Sbjct: 1222 WLQDARRRQEQIQAMPLADSQAVREQLRQEQALLEEIE 1259
>gi|41322914 plectin 1 isoform 10 [Homo sapiens]
Length = 4551
Score = 56.6 bits (135), Expect = 7e-08
Identities = 59/270 (21%), Positives = 123/270 (45%), Gaps = 29/270 (10%)
Query: 419 VSQSKELTKTEASKSISRQSEKAHSSGKLQKTVSYPDVSLEEQEKMDLKTSRELCSRLDA 478
+ Q KEL + +A + Q +K + +L + +LE + + L+ S E RL
Sbjct: 2336 LQQQKELAQEQARRL---QEDKEQMAQQLAEETQGFQRTLEAERQRQLEMSAE-AERLKL 2391
Query: 479 SISNNSTSKRKSESATCNLVRDINKVGIGL----VAAASSPLLVKDVICEDDKGKIMEEV 534
++ S ++ ++E + ++G L +A LV+ + + + E
Sbjct: 2392 RVAEMSRAQARAEEDAQRFRKQAEEIGEKLHRTELATQEKVTLVQTLEIQRQQSDHDAER 2451
Query: 535 MRTYLKQQEKLNLILQKKQQLQMEVKMLSSSKSMKELTEEQQNLQKELESLQNEHAQRME 594
+R + + E+ +K++LQ E K+L KS + T +Q+ L +E ++LQ +
Sbjct: 2452 LREAIAELER------EKEKLQQEAKLLQL-KSEEMQTVQQEQLLQETQALQQSFLSEKD 2504
Query: 595 EFYVEQKDLEK---KLEQIMKQKCTCDSNLEKDKEAEY----------AGQLAELRQRLD 641
++ +E+ KLEQ+ + + L ++++ + + E R+R
Sbjct: 2505 SLLQRERFIEQEKAKLEQLFQDEVAKAQQLREEQQRQQQQMEQERQRLVASMEEARRRQH 2564
Query: 642 HAEADRQELQDELRQ-EREARQKLEMMIKE 670
AE + Q+EL+Q E++ RQ+ E++ +E
Sbjct: 2565 EAEEGVRRKQEELQQLEQQRRQQEELLAEE 2594
Score = 52.4 bits (124), Expect = 1e-06
Identities = 68/284 (23%), Positives = 126/284 (44%), Gaps = 34/284 (11%)
Query: 420 SQSKELTKTEASKSISRQSEKAHSSGKLQKTVSYPDVSLEEQEKM----DLKTSRELCSR 475
SQ K + E + + ++E A + + + + EE E+ +++ +R++
Sbjct: 1511 SQRKRQAEVELASRVKAEAEAAREKQRALQALEELRLQAEEAERRLRQAEVERARQVQVA 1570
Query: 476 LDA---SISNNSTSKRKS-ESATCNLVRDINK--VGIGLVAAASSPLLVKDVICEDDKGK 529
L+ S SKR S T L R + + V + + + + E + +
Sbjct: 1571 LETAQRSAEAELQSKRASFAEKTAQLERSLQEEHVAVAQLREEAERRAQQQAEAERAREE 1630
Query: 530 IMEEVMRTYLKQQEKLNLILQKKQQLQMEVKMLSSSKSMKELTEEQQNLQKELESLQNEH 589
E+ R LK E L L LQ ++ Q KS+ + E+Q + E E+ +
Sbjct: 1631 AERELERWQLKANEALRLRLQAEEVAQQ--------KSLAQAEAEKQKEEAEREARRRGK 1682
Query: 590 AQRMEEFYVEQKDLEKKLEQIMKQKCTCDSNLEKDKEAEYAGQLAELRQRLDHAEADRQE 649
A EE V Q++L + +++ KQ+ + ++ AE +L LR + E RQ
Sbjct: 1683 A---EEQAVRQRELAE--QELEKQRQLAEGTAQQRLAAEQ--ELIRLRAETEQGEQQRQL 1735
Query: 650 LQDEL-RQEREA------RQKLEMMIKELK--LQILKSSKTAKE 684
L++EL R +REA RQ+LE + +++ +++L +SK E
Sbjct: 1736 LEEELARLQREAAAATQKRQELEAELAKVRAEMEVLLASKARAE 1779
Score = 44.3 bits (103), Expect = 4e-04
Identities = 65/296 (21%), Positives = 123/296 (41%), Gaps = 43/296 (14%)
Query: 421 QSKELTKTEASKSISRQSEKAHSSGK---------LQKTVSYPDVSLEE------QEKMD 465
+ + L + EA+ RQ +AH+ K LQ+ + V EE Q+K
Sbjct: 1362 ERERLAEVEAALEKQRQLAEAHAQAKAQAEREAKELQQRMQEEVVRREEAAVDAQQQKRS 1421
Query: 466 LKTS-RELCSRLDASISNNSTSKRKSESATCNLVRDINKVGIGLVAAAS---------SP 515
++ ++L +A I + +E + + +I V + L A
Sbjct: 1422 IQEELQQLRQSSEAEIQAKARQAEAAERSRLRIEEEIRVVRLQLEATERQRGGAEGELQA 1481
Query: 516 LLVKDVICEDDKGKIMEEVMRTYLKQQEKLNLILQKKQQLQMEVKMLSSSKSMKELTEEQ 575
L + E K + EE R + Q+ + +++ Q EV++ S K+ E E+
Sbjct: 1482 LRARAEEAEAQKRQAQEEAERLRRQVQD------ESQRKRQAEVELASRVKAEAEAAREK 1535
Query: 576 QNLQKELES--LQNEHAQRMEEFYVEQKDLEKKLE-QIMKQKCTCDSNLE-KDKEAEYAG 631
Q + LE LQ E A+R + Q ++E+ + Q+ + + E + K A +A
Sbjct: 1536 QRALQALEELRLQAEEAERR----LRQAEVERARQVQVALETAQRSAEAELQSKRASFAE 1591
Query: 632 QLAELRQRLDHAEAD----RQELQDELRQEREARQKLEMMIKELKLQILKSSKTAK 683
+ A+L + L R+E + +Q+ EA + E +EL+ LK+++ +
Sbjct: 1592 KTAQLERSLQEEHVAVAQLREEAERRAQQQAEAERAREEAERELERWQLKANEALR 1647
Score = 38.1 bits (87), Expect = 0.027
Identities = 28/140 (20%), Positives = 69/140 (49%), Gaps = 6/140 (4%)
Query: 551 KKQQLQMEVKMLSSSKSMKELTEEQQNLQKELESLQNEHAQRMEEFYVEQKDLEKKLEQI 610
K+ Q +M+ +++ ++ + ++++++Q+EL+ L+ ++ + + E+ +I
Sbjct: 1395 KELQQRMQEEVVRREEAAVDAQQQKRSIQEELQQLRQSSEAEIQAKARQAEAAERSRLRI 1454
Query: 611 MKQKCTCDSNLEKDKEAEYA--GQLAELRQRLDHAEADRQELQDEL----RQEREARQKL 664
++ LE + G+L LR R + AEA +++ Q+E RQ ++ Q+
Sbjct: 1455 EEEIRVVRLQLEATERQRGGAEGELQALRARAEEAEAQKRQAQEEAERLRRQVQDESQRK 1514
Query: 665 EMMIKELKLQILKSSKTAKE 684
EL ++ ++ A+E
Sbjct: 1515 RQAEVELASRVKAEAEAARE 1534
Score = 37.7 bits (86), Expect = 0.035
Identities = 41/161 (25%), Positives = 79/161 (49%), Gaps = 13/161 (8%)
Query: 516 LLVKDVICEDDKGKIMEEVMRTYLKQQEKLNLILQKKQQLQMEVKMLSSSKSMKELTEEQ 575
LL ++ E +K K+ E++ + + + ++L Q++QQ QME + SM+E Q
Sbjct: 2506 LLQRERFIEQEKAKL-EQLFQDEVAKAQQLREEQQRQQQ-QMEQERQRLVASMEEARRRQ 2563
Query: 576 -------QNLQKELESLQNEHAQRMEEFYVEQKDLEKKLEQIMKQKCTCDSNLEKDKEAE 628
+ Q+EL+ L+ + Q+ E E + L ++L+ + +Q ++ E+ ++
Sbjct: 2564 HEAEEGVRRKQEELQQLEQQRRQQEELLAEENQRLREQLQLLEEQHRAALAHSEEVTASQ 2623
Query: 629 YAG--QLAELRQRLD--HAEADRQELQDELRQEREARQKLE 665
A L R LD AEA+ + D LR++ A++ E
Sbjct: 2624 VAATKTLPNGRDALDGPAAEAEPEHSFDGLRRKVSAQRLQE 2664
Score = 35.8 bits (81), Expect = 0.13
Identities = 54/281 (19%), Positives = 116/281 (41%), Gaps = 36/281 (12%)
Query: 416 TSAVSQSKELTKTEASKSISRQSEKAHSSGKLQKTVSYPDVSLEEQEKMDLKTSRELCSR 475
T Q ++L + E ++ Q E A ++ K Q+ + E K+ + L S+
Sbjct: 1726 TEQGEQQRQLLEEELARL---QREAAAATQKRQELEA-------ELAKVRAEMEVLLASK 1775
Query: 476 LDASISNNSTSKRKSE--SATCNLVRDINKVGIGLVAAASSPLLVKDVICEDDKGKIMEE 533
A + STS++ + A R++ + L A A + + E+D + E
Sbjct: 1776 ARAEEESRSTSEKSKQRLEAEAGRFRELAEEAARLRALAEEAKRQRQ-LAEEDAARQRAE 1834
Query: 534 VMRTYLKQQEKLNLILQKKQQLQMEVKMLSS-SKSMKELTEEQQNLQKELESLQNEHAQR 592
R ++ + + K + ++ +K + ++ ++ L E++ ++ LE +H
Sbjct: 1835 AERVLAEKLAAIGEATRLKTEAEIALKEKEAENERLRRLAEDEAFQRRRLEEQAAQH--- 1891
Query: 593 MEEFYVEQKDLEKKLEQIMKQKCTCDSNLEKDK---------EAEYAGQLAELRQRLDHA 643
+ D+E++L Q+ K DS LE+ K + ++ L+ + A
Sbjct: 1892 -------KADIEERLAQLRK---ASDSELERQKGLVEDTLRQRRQVEEEILALKASFEKA 1941
Query: 644 EADRQELQDELRQEREARQKLEMMIKELKLQILKSSKTAKE 684
A + EL+ EL + R + ++ +L+ + + A E
Sbjct: 1942 AAGKAELELELGRIRSNAEDTLRSKEQAELEAARQRQLAAE 1982
Score = 35.0 bits (79), Expect = 0.23
Identities = 81/419 (19%), Positives = 162/419 (38%), Gaps = 86/419 (20%)
Query: 333 QKYLGTPEE--KKLKIILEEMKE-KFSMRSGKRNQSKTDAPSGMELQSWYPVIKQEGDHV 389
QK L EE ++ K LEE++ K + +R + + + S +LQ ++
Sbjct: 1995 QKSLAAEEEAARQRKAALEEVERLKAKVEEARRLRERAEQESARQLQLAQEAAQKRLQAE 2054
Query: 390 SQTHSFLHPSYYLYMCDKVVAPNVSLTSAVSQSKELT-----KTEASKSISRQSEKAHSS 444
+ H+F V L + Q + + + EA++ + ++E+A
Sbjct: 2055 EKAHAFA-----------VQQKEQELQQTLQQEQSVLDQLRGEAEAARRAAEEAEEARVQ 2103
Query: 445 GKLQKTVSYPDVSLEEQEKMDLKTSRELCSRLDASISNNSTSKRKSESATCNLVRDINKV 504
+ + S V EE E++ + +R A + K + A + +
Sbjct: 2104 AEREAAQSRRQV--EEAERLKQSAEEQAQARAQAQAAAEKLRKEAEQEAARRAQAE--QA 2159
Query: 505 GIGLVAAASSPLLVKDVICED---DKGKIMEEVMRTYLKQQE---KLNLILQKKQQL--- 555
+ AA + + E K ++ +E+ L+ +E + NL+ ++ Q+L
Sbjct: 2160 ALRQKQAADAEMEKHKKFAEQTLRQKAQVEQELTTLRLQLEETDHQKNLLDEELQRLKAE 2219
Query: 556 ---------QMEVKMLSSSKSMKELTE-------------------EQQNLQKELESLQN 587
Q+E ++ S M+EL++ Q+ LQ+E E ++
Sbjct: 2220 ATEAARQRSQVEEELFSVRVQMEELSKLKARIEAENRALILRDKDNTQRFLQEEAEKMKQ 2279
Query: 588 --EHAQRMEEFYVEQKDLEKKLEQIMKQKCTCDSNLEKDK------------EAEYAGQL 633
E A R+ E L + E+ + Q+ + K+K EAE Q
Sbjct: 2280 VAEEAARLSVAAQEAARLRQLAEEDLAQQRALAEKMLKEKMQAVQEATRLKAEAELLQQQ 2339
Query: 634 AELRQ-RLDHAEADRQELQDELRQ---------EREARQKLEMM--IKELKLQILKSSK 680
EL Q + + D++++ +L + E E +++LEM + LKL++ + S+
Sbjct: 2340 KELAQEQARRLQEDKEQMAQQLAEETQGFQRTLEAERQRQLEMSAEAERLKLRVAEMSR 2398
Score = 32.0 bits (71), Expect = 1.9
Identities = 34/158 (21%), Positives = 73/158 (46%), Gaps = 24/158 (15%)
Query: 532 EEVMRTY---LKQQEKLNLILQKKQQLQMEVKMLSSSKSMKE-----LTEEQQNLQKELE 583
EEV+R + LK+ + + L + + + +K L + ++ L +E + Q+ E
Sbjct: 1106 EEVLRAHEEQLKEAQAVPATLPELEATKASLKKLRAQAEAQQPTFDALRDELRGAQEVGE 1165
Query: 584 SLQNEHAQR---MEEFYVEQKDLEKKLEQIMKQKCTCDSNLEK-DKEAEYAGQ------- 632
LQ H +R +E + L ++ + ++ Q LE+ ++ Y +
Sbjct: 1166 RLQQRHGERDVEVERWRERVAQLLERWQAVLAQTDVRQRELEQLGRQLRYYRESADPLGA 1225
Query: 633 -LAELRQRLDHAEA----DRQELQDELRQEREARQKLE 665
L + R+R + +A D Q ++++LRQE+ +++E
Sbjct: 1226 WLQDARRRQEQIQAMPLADSQAVREQLRQEQALLEEIE 1263
>gi|41322919 plectin 1 isoform 8 [Homo sapiens]
Length = 4547
Score = 56.6 bits (135), Expect = 7e-08
Identities = 59/270 (21%), Positives = 123/270 (45%), Gaps = 29/270 (10%)
Query: 419 VSQSKELTKTEASKSISRQSEKAHSSGKLQKTVSYPDVSLEEQEKMDLKTSRELCSRLDA 478
+ Q KEL + +A + Q +K + +L + +LE + + L+ S E RL
Sbjct: 2332 LQQQKELAQEQARRL---QEDKEQMAQQLAEETQGFQRTLEAERQRQLEMSAE-AERLKL 2387
Query: 479 SISNNSTSKRKSESATCNLVRDINKVGIGL----VAAASSPLLVKDVICEDDKGKIMEEV 534
++ S ++ ++E + ++G L +A LV+ + + + E
Sbjct: 2388 RVAEMSRAQARAEEDAQRFRKQAEEIGEKLHRTELATQEKVTLVQTLEIQRQQSDHDAER 2447
Query: 535 MRTYLKQQEKLNLILQKKQQLQMEVKMLSSSKSMKELTEEQQNLQKELESLQNEHAQRME 594
+R + + E+ +K++LQ E K+L KS + T +Q+ L +E ++LQ +
Sbjct: 2448 LREAIAELER------EKEKLQQEAKLLQL-KSEEMQTVQQEQLLQETQALQQSFLSEKD 2500
Query: 595 EFYVEQKDLEK---KLEQIMKQKCTCDSNLEKDKEAEY----------AGQLAELRQRLD 641
++ +E+ KLEQ+ + + L ++++ + + E R+R
Sbjct: 2501 SLLQRERFIEQEKAKLEQLFQDEVAKAQQLREEQQRQQQQMEQERQRLVASMEEARRRQH 2560
Query: 642 HAEADRQELQDELRQ-EREARQKLEMMIKE 670
AE + Q+EL+Q E++ RQ+ E++ +E
Sbjct: 2561 EAEEGVRRKQEELQQLEQQRRQQEELLAEE 2590
Score = 52.4 bits (124), Expect = 1e-06
Identities = 68/284 (23%), Positives = 126/284 (44%), Gaps = 34/284 (11%)
Query: 420 SQSKELTKTEASKSISRQSEKAHSSGKLQKTVSYPDVSLEEQEKM----DLKTSRELCSR 475
SQ K + E + + ++E A + + + + EE E+ +++ +R++
Sbjct: 1507 SQRKRQAEVELASRVKAEAEAAREKQRALQALEELRLQAEEAERRLRQAEVERARQVQVA 1566
Query: 476 LDA---SISNNSTSKRKS-ESATCNLVRDINK--VGIGLVAAASSPLLVKDVICEDDKGK 529
L+ S SKR S T L R + + V + + + + E + +
Sbjct: 1567 LETAQRSAEAELQSKRASFAEKTAQLERSLQEEHVAVAQLREEAERRAQQQAEAERAREE 1626
Query: 530 IMEEVMRTYLKQQEKLNLILQKKQQLQMEVKMLSSSKSMKELTEEQQNLQKELESLQNEH 589
E+ R LK E L L LQ ++ Q KS+ + E+Q + E E+ +
Sbjct: 1627 AERELERWQLKANEALRLRLQAEEVAQQ--------KSLAQAEAEKQKEEAEREARRRGK 1678
Query: 590 AQRMEEFYVEQKDLEKKLEQIMKQKCTCDSNLEKDKEAEYAGQLAELRQRLDHAEADRQE 649
A EE V Q++L + +++ KQ+ + ++ AE +L LR + E RQ
Sbjct: 1679 A---EEQAVRQRELAE--QELEKQRQLAEGTAQQRLAAEQ--ELIRLRAETEQGEQQRQL 1731
Query: 650 LQDEL-RQEREA------RQKLEMMIKELK--LQILKSSKTAKE 684
L++EL R +REA RQ+LE + +++ +++L +SK E
Sbjct: 1732 LEEELARLQREAAAATQKRQELEAELAKVRAEMEVLLASKARAE 1775
Score = 44.3 bits (103), Expect = 4e-04
Identities = 65/296 (21%), Positives = 123/296 (41%), Gaps = 43/296 (14%)
Query: 421 QSKELTKTEASKSISRQSEKAHSSGK---------LQKTVSYPDVSLEE------QEKMD 465
+ + L + EA+ RQ +AH+ K LQ+ + V EE Q+K
Sbjct: 1358 ERERLAEVEAALEKQRQLAEAHAQAKAQAEREAKELQQRMQEEVVRREEAAVDAQQQKRS 1417
Query: 466 LKTS-RELCSRLDASISNNSTSKRKSESATCNLVRDINKVGIGLVAAAS---------SP 515
++ ++L +A I + +E + + +I V + L A
Sbjct: 1418 IQEELQQLRQSSEAEIQAKARQAEAAERSRLRIEEEIRVVRLQLEATERQRGGAEGELQA 1477
Query: 516 LLVKDVICEDDKGKIMEEVMRTYLKQQEKLNLILQKKQQLQMEVKMLSSSKSMKELTEEQ 575
L + E K + EE R + Q+ + +++ Q EV++ S K+ E E+
Sbjct: 1478 LRARAEEAEAQKRQAQEEAERLRRQVQD------ESQRKRQAEVELASRVKAEAEAAREK 1531
Query: 576 QNLQKELES--LQNEHAQRMEEFYVEQKDLEKKLE-QIMKQKCTCDSNLE-KDKEAEYAG 631
Q + LE LQ E A+R + Q ++E+ + Q+ + + E + K A +A
Sbjct: 1532 QRALQALEELRLQAEEAERR----LRQAEVERARQVQVALETAQRSAEAELQSKRASFAE 1587
Query: 632 QLAELRQRLDHAEAD----RQELQDELRQEREARQKLEMMIKELKLQILKSSKTAK 683
+ A+L + L R+E + +Q+ EA + E +EL+ LK+++ +
Sbjct: 1588 KTAQLERSLQEEHVAVAQLREEAERRAQQQAEAERAREEAERELERWQLKANEALR 1643
Score = 38.1 bits (87), Expect = 0.027
Identities = 28/140 (20%), Positives = 69/140 (49%), Gaps = 6/140 (4%)
Query: 551 KKQQLQMEVKMLSSSKSMKELTEEQQNLQKELESLQNEHAQRMEEFYVEQKDLEKKLEQI 610
K+ Q +M+ +++ ++ + ++++++Q+EL+ L+ ++ + + E+ +I
Sbjct: 1391 KELQQRMQEEVVRREEAAVDAQQQKRSIQEELQQLRQSSEAEIQAKARQAEAAERSRLRI 1450
Query: 611 MKQKCTCDSNLEKDKEAEYA--GQLAELRQRLDHAEADRQELQDEL----RQEREARQKL 664
++ LE + G+L LR R + AEA +++ Q+E RQ ++ Q+
Sbjct: 1451 EEEIRVVRLQLEATERQRGGAEGELQALRARAEEAEAQKRQAQEEAERLRRQVQDESQRK 1510
Query: 665 EMMIKELKLQILKSSKTAKE 684
EL ++ ++ A+E
Sbjct: 1511 RQAEVELASRVKAEAEAARE 1530
Score = 37.7 bits (86), Expect = 0.035
Identities = 41/161 (25%), Positives = 79/161 (49%), Gaps = 13/161 (8%)
Query: 516 LLVKDVICEDDKGKIMEEVMRTYLKQQEKLNLILQKKQQLQMEVKMLSSSKSMKELTEEQ 575
LL ++ E +K K+ E++ + + + ++L Q++QQ QME + SM+E Q
Sbjct: 2502 LLQRERFIEQEKAKL-EQLFQDEVAKAQQLREEQQRQQQ-QMEQERQRLVASMEEARRRQ 2559
Query: 576 -------QNLQKELESLQNEHAQRMEEFYVEQKDLEKKLEQIMKQKCTCDSNLEKDKEAE 628
+ Q+EL+ L+ + Q+ E E + L ++L+ + +Q ++ E+ ++
Sbjct: 2560 HEAEEGVRRKQEELQQLEQQRRQQEELLAEENQRLREQLQLLEEQHRAALAHSEEVTASQ 2619
Query: 629 YAG--QLAELRQRLD--HAEADRQELQDELRQEREARQKLE 665
A L R LD AEA+ + D LR++ A++ E
Sbjct: 2620 VAATKTLPNGRDALDGPAAEAEPEHSFDGLRRKVSAQRLQE 2660
Score = 35.8 bits (81), Expect = 0.13
Identities = 54/281 (19%), Positives = 116/281 (41%), Gaps = 36/281 (12%)
Query: 416 TSAVSQSKELTKTEASKSISRQSEKAHSSGKLQKTVSYPDVSLEEQEKMDLKTSRELCSR 475
T Q ++L + E ++ Q E A ++ K Q+ + E K+ + L S+
Sbjct: 1722 TEQGEQQRQLLEEELARL---QREAAAATQKRQELEA-------ELAKVRAEMEVLLASK 1771
Query: 476 LDASISNNSTSKRKSE--SATCNLVRDINKVGIGLVAAASSPLLVKDVICEDDKGKIMEE 533
A + STS++ + A R++ + L A A + + E+D + E
Sbjct: 1772 ARAEEESRSTSEKSKQRLEAEAGRFRELAEEAARLRALAEEAKRQRQ-LAEEDAARQRAE 1830
Query: 534 VMRTYLKQQEKLNLILQKKQQLQMEVKMLSS-SKSMKELTEEQQNLQKELESLQNEHAQR 592
R ++ + + K + ++ +K + ++ ++ L E++ ++ LE +H
Sbjct: 1831 AERVLAEKLAAIGEATRLKTEAEIALKEKEAENERLRRLAEDEAFQRRRLEEQAAQH--- 1887
Query: 593 MEEFYVEQKDLEKKLEQIMKQKCTCDSNLEKDK---------EAEYAGQLAELRQRLDHA 643
+ D+E++L Q+ K DS LE+ K + ++ L+ + A
Sbjct: 1888 -------KADIEERLAQLRK---ASDSELERQKGLVEDTLRQRRQVEEEILALKASFEKA 1937
Query: 644 EADRQELQDELRQEREARQKLEMMIKELKLQILKSSKTAKE 684
A + EL+ EL + R + ++ +L+ + + A E
Sbjct: 1938 AAGKAELELELGRIRSNAEDTLRSKEQAELEAARQRQLAAE 1978
Score = 35.0 bits (79), Expect = 0.23
Identities = 81/419 (19%), Positives = 162/419 (38%), Gaps = 86/419 (20%)
Query: 333 QKYLGTPEE--KKLKIILEEMKE-KFSMRSGKRNQSKTDAPSGMELQSWYPVIKQEGDHV 389
QK L EE ++ K LEE++ K + +R + + + S +LQ ++
Sbjct: 1991 QKSLAAEEEAARQRKAALEEVERLKAKVEEARRLRERAEQESARQLQLAQEAAQKRLQAE 2050
Query: 390 SQTHSFLHPSYYLYMCDKVVAPNVSLTSAVSQSKELT-----KTEASKSISRQSEKAHSS 444
+ H+F V L + Q + + + EA++ + ++E+A
Sbjct: 2051 EKAHAFA-----------VQQKEQELQQTLQQEQSVLDQLRGEAEAARRAAEEAEEARVQ 2099
Query: 445 GKLQKTVSYPDVSLEEQEKMDLKTSRELCSRLDASISNNSTSKRKSESATCNLVRDINKV 504
+ + S V EE E++ + +R A + K + A + +
Sbjct: 2100 AEREAAQSRRQV--EEAERLKQSAEEQAQARAQAQAAAEKLRKEAEQEAARRAQAE--QA 2155
Query: 505 GIGLVAAASSPLLVKDVICED---DKGKIMEEVMRTYLKQQE---KLNLILQKKQQL--- 555
+ AA + + E K ++ +E+ L+ +E + NL+ ++ Q+L
Sbjct: 2156 ALRQKQAADAEMEKHKKFAEQTLRQKAQVEQELTTLRLQLEETDHQKNLLDEELQRLKAE 2215
Query: 556 ---------QMEVKMLSSSKSMKELTE-------------------EQQNLQKELESLQN 587
Q+E ++ S M+EL++ Q+ LQ+E E ++
Sbjct: 2216 ATEAARQRSQVEEELFSVRVQMEELSKLKARIEAENRALILRDKDNTQRFLQEEAEKMKQ 2275
Query: 588 --EHAQRMEEFYVEQKDLEKKLEQIMKQKCTCDSNLEKDK------------EAEYAGQL 633
E A R+ E L + E+ + Q+ + K+K EAE Q
Sbjct: 2276 VAEEAARLSVAAQEAARLRQLAEEDLAQQRALAEKMLKEKMQAVQEATRLKAEAELLQQQ 2335
Query: 634 AELRQ-RLDHAEADRQELQDELRQ---------EREARQKLEMM--IKELKLQILKSSK 680
EL Q + + D++++ +L + E E +++LEM + LKL++ + S+
Sbjct: 2336 KELAQEQARRLQEDKEQMAQQLAEETQGFQRTLEAERQRQLEMSAEAERLKLRVAEMSR 2394
Score = 32.0 bits (71), Expect = 1.9
Identities = 34/158 (21%), Positives = 73/158 (46%), Gaps = 24/158 (15%)
Query: 532 EEVMRTY---LKQQEKLNLILQKKQQLQMEVKMLSSSKSMKE-----LTEEQQNLQKELE 583
EEV+R + LK+ + + L + + + +K L + ++ L +E + Q+ E
Sbjct: 1102 EEVLRAHEEQLKEAQAVPATLPELEATKASLKKLRAQAEAQQPTFDALRDELRGAQEVGE 1161
Query: 584 SLQNEHAQR---MEEFYVEQKDLEKKLEQIMKQKCTCDSNLEK-DKEAEYAGQ------- 632
LQ H +R +E + L ++ + ++ Q LE+ ++ Y +
Sbjct: 1162 RLQQRHGERDVEVERWRERVAQLLERWQAVLAQTDVRQRELEQLGRQLRYYRESADPLGA 1221
Query: 633 -LAELRQRLDHAEA----DRQELQDELRQEREARQKLE 665
L + R+R + +A D Q ++++LRQE+ +++E
Sbjct: 1222 WLQDARRRQEQIQAMPLADSQAVREQLRQEQALLEEIE 1259
>gi|41322910 plectin 1 isoform 7 [Homo sapiens]
Length = 4515
Score = 56.6 bits (135), Expect = 7e-08
Identities = 59/270 (21%), Positives = 123/270 (45%), Gaps = 29/270 (10%)
Query: 419 VSQSKELTKTEASKSISRQSEKAHSSGKLQKTVSYPDVSLEEQEKMDLKTSRELCSRLDA 478
+ Q KEL + +A + Q +K + +L + +LE + + L+ S E RL
Sbjct: 2300 LQQQKELAQEQARRL---QEDKEQMAQQLAEETQGFQRTLEAERQRQLEMSAE-AERLKL 2355
Query: 479 SISNNSTSKRKSESATCNLVRDINKVGIGL----VAAASSPLLVKDVICEDDKGKIMEEV 534
++ S ++ ++E + ++G L +A LV+ + + + E
Sbjct: 2356 RVAEMSRAQARAEEDAQRFRKQAEEIGEKLHRTELATQEKVTLVQTLEIQRQQSDHDAER 2415
Query: 535 MRTYLKQQEKLNLILQKKQQLQMEVKMLSSSKSMKELTEEQQNLQKELESLQNEHAQRME 594
+R + + E+ +K++LQ E K+L KS + T +Q+ L +E ++LQ +
Sbjct: 2416 LREAIAELER------EKEKLQQEAKLLQL-KSEEMQTVQQEQLLQETQALQQSFLSEKD 2468
Query: 595 EFYVEQKDLEK---KLEQIMKQKCTCDSNLEKDKEAEY----------AGQLAELRQRLD 641
++ +E+ KLEQ+ + + L ++++ + + E R+R
Sbjct: 2469 SLLQRERFIEQEKAKLEQLFQDEVAKAQQLREEQQRQQQQMEQERQRLVASMEEARRRQH 2528
Query: 642 HAEADRQELQDELRQ-EREARQKLEMMIKE 670
AE + Q+EL+Q E++ RQ+ E++ +E
Sbjct: 2529 EAEEGVRRKQEELQQLEQQRRQQEELLAEE 2558
Score = 52.4 bits (124), Expect = 1e-06
Identities = 68/284 (23%), Positives = 126/284 (44%), Gaps = 34/284 (11%)
Query: 420 SQSKELTKTEASKSISRQSEKAHSSGKLQKTVSYPDVSLEEQEKM----DLKTSRELCSR 475
SQ K + E + + ++E A + + + + EE E+ +++ +R++
Sbjct: 1475 SQRKRQAEVELASRVKAEAEAAREKQRALQALEELRLQAEEAERRLRQAEVERARQVQVA 1534
Query: 476 LDA---SISNNSTSKRKS-ESATCNLVRDINK--VGIGLVAAASSPLLVKDVICEDDKGK 529
L+ S SKR S T L R + + V + + + + E + +
Sbjct: 1535 LETAQRSAEAELQSKRASFAEKTAQLERSLQEEHVAVAQLREEAERRAQQQAEAERAREE 1594
Query: 530 IMEEVMRTYLKQQEKLNLILQKKQQLQMEVKMLSSSKSMKELTEEQQNLQKELESLQNEH 589
E+ R LK E L L LQ ++ Q KS+ + E+Q + E E+ +
Sbjct: 1595 AERELERWQLKANEALRLRLQAEEVAQQ--------KSLAQAEAEKQKEEAEREARRRGK 1646
Query: 590 AQRMEEFYVEQKDLEKKLEQIMKQKCTCDSNLEKDKEAEYAGQLAELRQRLDHAEADRQE 649
A EE V Q++L + +++ KQ+ + ++ AE +L LR + E RQ
Sbjct: 1647 A---EEQAVRQRELAE--QELEKQRQLAEGTAQQRLAAEQ--ELIRLRAETEQGEQQRQL 1699
Query: 650 LQDEL-RQEREA------RQKLEMMIKELK--LQILKSSKTAKE 684
L++EL R +REA RQ+LE + +++ +++L +SK E
Sbjct: 1700 LEEELARLQREAAAATQKRQELEAELAKVRAEMEVLLASKARAE 1743
Score = 44.3 bits (103), Expect = 4e-04
Identities = 65/296 (21%), Positives = 123/296 (41%), Gaps = 43/296 (14%)
Query: 421 QSKELTKTEASKSISRQSEKAHSSGK---------LQKTVSYPDVSLEE------QEKMD 465
+ + L + EA+ RQ +AH+ K LQ+ + V EE Q+K
Sbjct: 1326 ERERLAEVEAALEKQRQLAEAHAQAKAQAEREAKELQQRMQEEVVRREEAAVDAQQQKRS 1385
Query: 466 LKTS-RELCSRLDASISNNSTSKRKSESATCNLVRDINKVGIGLVAAAS---------SP 515
++ ++L +A I + +E + + +I V + L A
Sbjct: 1386 IQEELQQLRQSSEAEIQAKARQAEAAERSRLRIEEEIRVVRLQLEATERQRGGAEGELQA 1445
Query: 516 LLVKDVICEDDKGKIMEEVMRTYLKQQEKLNLILQKKQQLQMEVKMLSSSKSMKELTEEQ 575
L + E K + EE R + Q+ + +++ Q EV++ S K+ E E+
Sbjct: 1446 LRARAEEAEAQKRQAQEEAERLRRQVQD------ESQRKRQAEVELASRVKAEAEAAREK 1499
Query: 576 QNLQKELES--LQNEHAQRMEEFYVEQKDLEKKLE-QIMKQKCTCDSNLE-KDKEAEYAG 631
Q + LE LQ E A+R + Q ++E+ + Q+ + + E + K A +A
Sbjct: 1500 QRALQALEELRLQAEEAERR----LRQAEVERARQVQVALETAQRSAEAELQSKRASFAE 1555
Query: 632 QLAELRQRLDHAEAD----RQELQDELRQEREARQKLEMMIKELKLQILKSSKTAK 683
+ A+L + L R+E + +Q+ EA + E +EL+ LK+++ +
Sbjct: 1556 KTAQLERSLQEEHVAVAQLREEAERRAQQQAEAERAREEAERELERWQLKANEALR 1611
Score = 38.1 bits (87), Expect = 0.027
Identities = 28/140 (20%), Positives = 69/140 (49%), Gaps = 6/140 (4%)
Query: 551 KKQQLQMEVKMLSSSKSMKELTEEQQNLQKELESLQNEHAQRMEEFYVEQKDLEKKLEQI 610
K+ Q +M+ +++ ++ + ++++++Q+EL+ L+ ++ + + E+ +I
Sbjct: 1359 KELQQRMQEEVVRREEAAVDAQQQKRSIQEELQQLRQSSEAEIQAKARQAEAAERSRLRI 1418
Query: 611 MKQKCTCDSNLEKDKEAEYA--GQLAELRQRLDHAEADRQELQDEL----RQEREARQKL 664
++ LE + G+L LR R + AEA +++ Q+E RQ ++ Q+
Sbjct: 1419 EEEIRVVRLQLEATERQRGGAEGELQALRARAEEAEAQKRQAQEEAERLRRQVQDESQRK 1478
Query: 665 EMMIKELKLQILKSSKTAKE 684
EL ++ ++ A+E
Sbjct: 1479 RQAEVELASRVKAEAEAARE 1498
Score = 37.7 bits (86), Expect = 0.035
Identities = 41/161 (25%), Positives = 79/161 (49%), Gaps = 13/161 (8%)
Query: 516 LLVKDVICEDDKGKIMEEVMRTYLKQQEKLNLILQKKQQLQMEVKMLSSSKSMKELTEEQ 575
LL ++ E +K K+ E++ + + + ++L Q++QQ QME + SM+E Q
Sbjct: 2470 LLQRERFIEQEKAKL-EQLFQDEVAKAQQLREEQQRQQQ-QMEQERQRLVASMEEARRRQ 2527
Query: 576 -------QNLQKELESLQNEHAQRMEEFYVEQKDLEKKLEQIMKQKCTCDSNLEKDKEAE 628
+ Q+EL+ L+ + Q+ E E + L ++L+ + +Q ++ E+ ++
Sbjct: 2528 HEAEEGVRRKQEELQQLEQQRRQQEELLAEENQRLREQLQLLEEQHRAALAHSEEVTASQ 2587
Query: 629 YAG--QLAELRQRLD--HAEADRQELQDELRQEREARQKLE 665
A L R LD AEA+ + D LR++ A++ E
Sbjct: 2588 VAATKTLPNGRDALDGPAAEAEPEHSFDGLRRKVSAQRLQE 2628
Score = 35.8 bits (81), Expect = 0.13
Identities = 54/281 (19%), Positives = 116/281 (41%), Gaps = 36/281 (12%)
Query: 416 TSAVSQSKELTKTEASKSISRQSEKAHSSGKLQKTVSYPDVSLEEQEKMDLKTSRELCSR 475
T Q ++L + E ++ Q E A ++ K Q+ + E K+ + L S+
Sbjct: 1690 TEQGEQQRQLLEEELARL---QREAAAATQKRQELEA-------ELAKVRAEMEVLLASK 1739
Query: 476 LDASISNNSTSKRKSE--SATCNLVRDINKVGIGLVAAASSPLLVKDVICEDDKGKIMEE 533
A + STS++ + A R++ + L A A + + E+D + E
Sbjct: 1740 ARAEEESRSTSEKSKQRLEAEAGRFRELAEEAARLRALAEEAKRQRQ-LAEEDAARQRAE 1798
Query: 534 VMRTYLKQQEKLNLILQKKQQLQMEVKMLSS-SKSMKELTEEQQNLQKELESLQNEHAQR 592
R ++ + + K + ++ +K + ++ ++ L E++ ++ LE +H
Sbjct: 1799 AERVLAEKLAAIGEATRLKTEAEIALKEKEAENERLRRLAEDEAFQRRRLEEQAAQH--- 1855
Query: 593 MEEFYVEQKDLEKKLEQIMKQKCTCDSNLEKDK---------EAEYAGQLAELRQRLDHA 643
+ D+E++L Q+ K DS LE+ K + ++ L+ + A
Sbjct: 1856 -------KADIEERLAQLRK---ASDSELERQKGLVEDTLRQRRQVEEEILALKASFEKA 1905
Query: 644 EADRQELQDELRQEREARQKLEMMIKELKLQILKSSKTAKE 684
A + EL+ EL + R + ++ +L+ + + A E
Sbjct: 1906 AAGKAELELELGRIRSNAEDTLRSKEQAELEAARQRQLAAE 1946
Score = 35.0 bits (79), Expect = 0.23
Identities = 81/419 (19%), Positives = 162/419 (38%), Gaps = 86/419 (20%)
Query: 333 QKYLGTPEE--KKLKIILEEMKE-KFSMRSGKRNQSKTDAPSGMELQSWYPVIKQEGDHV 389
QK L EE ++ K LEE++ K + +R + + + S +LQ ++
Sbjct: 1959 QKSLAAEEEAARQRKAALEEVERLKAKVEEARRLRERAEQESARQLQLAQEAAQKRLQAE 2018
Query: 390 SQTHSFLHPSYYLYMCDKVVAPNVSLTSAVSQSKELT-----KTEASKSISRQSEKAHSS 444
+ H+F V L + Q + + + EA++ + ++E+A
Sbjct: 2019 EKAHAFA-----------VQQKEQELQQTLQQEQSVLDQLRGEAEAARRAAEEAEEARVQ 2067
Query: 445 GKLQKTVSYPDVSLEEQEKMDLKTSRELCSRLDASISNNSTSKRKSESATCNLVRDINKV 504
+ + S V EE E++ + +R A + K + A + +
Sbjct: 2068 AEREAAQSRRQV--EEAERLKQSAEEQAQARAQAQAAAEKLRKEAEQEAARRAQAE--QA 2123
Query: 505 GIGLVAAASSPLLVKDVICED---DKGKIMEEVMRTYLKQQE---KLNLILQKKQQL--- 555
+ AA + + E K ++ +E+ L+ +E + NL+ ++ Q+L
Sbjct: 2124 ALRQKQAADAEMEKHKKFAEQTLRQKAQVEQELTTLRLQLEETDHQKNLLDEELQRLKAE 2183
Query: 556 ---------QMEVKMLSSSKSMKELTE-------------------EQQNLQKELESLQN 587
Q+E ++ S M+EL++ Q+ LQ+E E ++
Sbjct: 2184 ATEAARQRSQVEEELFSVRVQMEELSKLKARIEAENRALILRDKDNTQRFLQEEAEKMKQ 2243
Query: 588 --EHAQRMEEFYVEQKDLEKKLEQIMKQKCTCDSNLEKDK------------EAEYAGQL 633
E A R+ E L + E+ + Q+ + K+K EAE Q
Sbjct: 2244 VAEEAARLSVAAQEAARLRQLAEEDLAQQRALAEKMLKEKMQAVQEATRLKAEAELLQQQ 2303
Query: 634 AELRQ-RLDHAEADRQELQDELRQ---------EREARQKLEMM--IKELKLQILKSSK 680
EL Q + + D++++ +L + E E +++LEM + LKL++ + S+
Sbjct: 2304 KELAQEQARRLQEDKEQMAQQLAEETQGFQRTLEAERQRQLEMSAEAERLKLRVAEMSR 2362
Score = 32.0 bits (71), Expect = 1.9
Identities = 34/158 (21%), Positives = 73/158 (46%), Gaps = 24/158 (15%)
Query: 532 EEVMRTY---LKQQEKLNLILQKKQQLQMEVKMLSSSKSMKE-----LTEEQQNLQKELE 583
EEV+R + LK+ + + L + + + +K L + ++ L +E + Q+ E
Sbjct: 1070 EEVLRAHEEQLKEAQAVPATLPELEATKASLKKLRAQAEAQQPTFDALRDELRGAQEVGE 1129
Query: 584 SLQNEHAQR---MEEFYVEQKDLEKKLEQIMKQKCTCDSNLEK-DKEAEYAGQ------- 632
LQ H +R +E + L ++ + ++ Q LE+ ++ Y +
Sbjct: 1130 RLQQRHGERDVEVERWRERVAQLLERWQAVLAQTDVRQRELEQLGRQLRYYRESADPLGA 1189
Query: 633 -LAELRQRLDHAEA----DRQELQDELRQEREARQKLE 665
L + R+R + +A D Q ++++LRQE+ +++E
Sbjct: 1190 WLQDARRRQEQIQAMPLADSQAVREQLRQEQALLEEIE 1227
>gi|41322916 plectin 1 isoform 6 [Homo sapiens]
Length = 4684
Score = 56.6 bits (135), Expect = 7e-08
Identities = 59/270 (21%), Positives = 123/270 (45%), Gaps = 29/270 (10%)
Query: 419 VSQSKELTKTEASKSISRQSEKAHSSGKLQKTVSYPDVSLEEQEKMDLKTSRELCSRLDA 478
+ Q KEL + +A + Q +K + +L + +LE + + L+ S E RL
Sbjct: 2469 LQQQKELAQEQARRL---QEDKEQMAQQLAEETQGFQRTLEAERQRQLEMSAE-AERLKL 2524
Query: 479 SISNNSTSKRKSESATCNLVRDINKVGIGL----VAAASSPLLVKDVICEDDKGKIMEEV 534
++ S ++ ++E + ++G L +A LV+ + + + E
Sbjct: 2525 RVAEMSRAQARAEEDAQRFRKQAEEIGEKLHRTELATQEKVTLVQTLEIQRQQSDHDAER 2584
Query: 535 MRTYLKQQEKLNLILQKKQQLQMEVKMLSSSKSMKELTEEQQNLQKELESLQNEHAQRME 594
+R + + E+ +K++LQ E K+L KS + T +Q+ L +E ++LQ +
Sbjct: 2585 LREAIAELER------EKEKLQQEAKLLQL-KSEEMQTVQQEQLLQETQALQQSFLSEKD 2637
Query: 595 EFYVEQKDLEK---KLEQIMKQKCTCDSNLEKDKEAEY----------AGQLAELRQRLD 641
++ +E+ KLEQ+ + + L ++++ + + E R+R
Sbjct: 2638 SLLQRERFIEQEKAKLEQLFQDEVAKAQQLREEQQRQQQQMEQERQRLVASMEEARRRQH 2697
Query: 642 HAEADRQELQDELRQ-EREARQKLEMMIKE 670
AE + Q+EL+Q E++ RQ+ E++ +E
Sbjct: 2698 EAEEGVRRKQEELQQLEQQRRQQEELLAEE 2727
Score = 52.4 bits (124), Expect = 1e-06
Identities = 68/284 (23%), Positives = 126/284 (44%), Gaps = 34/284 (11%)
Query: 420 SQSKELTKTEASKSISRQSEKAHSSGKLQKTVSYPDVSLEEQEKM----DLKTSRELCSR 475
SQ K + E + + ++E A + + + + EE E+ +++ +R++
Sbjct: 1644 SQRKRQAEVELASRVKAEAEAAREKQRALQALEELRLQAEEAERRLRQAEVERARQVQVA 1703
Query: 476 LDA---SISNNSTSKRKS-ESATCNLVRDINK--VGIGLVAAASSPLLVKDVICEDDKGK 529
L+ S SKR S T L R + + V + + + + E + +
Sbjct: 1704 LETAQRSAEAELQSKRASFAEKTAQLERSLQEEHVAVAQLREEAERRAQQQAEAERAREE 1763
Query: 530 IMEEVMRTYLKQQEKLNLILQKKQQLQMEVKMLSSSKSMKELTEEQQNLQKELESLQNEH 589
E+ R LK E L L LQ ++ Q KS+ + E+Q + E E+ +
Sbjct: 1764 AERELERWQLKANEALRLRLQAEEVAQQ--------KSLAQAEAEKQKEEAEREARRRGK 1815
Query: 590 AQRMEEFYVEQKDLEKKLEQIMKQKCTCDSNLEKDKEAEYAGQLAELRQRLDHAEADRQE 649
A EE V Q++L + +++ KQ+ + ++ AE +L LR + E RQ
Sbjct: 1816 A---EEQAVRQRELAE--QELEKQRQLAEGTAQQRLAAEQ--ELIRLRAETEQGEQQRQL 1868
Query: 650 LQDEL-RQEREA------RQKLEMMIKELK--LQILKSSKTAKE 684
L++EL R +REA RQ+LE + +++ +++L +SK E
Sbjct: 1869 LEEELARLQREAAAATQKRQELEAELAKVRAEMEVLLASKARAE 1912
Score = 44.3 bits (103), Expect = 4e-04
Identities = 65/296 (21%), Positives = 123/296 (41%), Gaps = 43/296 (14%)
Query: 421 QSKELTKTEASKSISRQSEKAHSSGK---------LQKTVSYPDVSLEE------QEKMD 465
+ + L + EA+ RQ +AH+ K LQ+ + V EE Q+K
Sbjct: 1495 ERERLAEVEAALEKQRQLAEAHAQAKAQAEREAKELQQRMQEEVVRREEAAVDAQQQKRS 1554
Query: 466 LKTS-RELCSRLDASISNNSTSKRKSESATCNLVRDINKVGIGLVAAAS---------SP 515
++ ++L +A I + +E + + +I V + L A
Sbjct: 1555 IQEELQQLRQSSEAEIQAKARQAEAAERSRLRIEEEIRVVRLQLEATERQRGGAEGELQA 1614
Query: 516 LLVKDVICEDDKGKIMEEVMRTYLKQQEKLNLILQKKQQLQMEVKMLSSSKSMKELTEEQ 575
L + E K + EE R + Q+ + +++ Q EV++ S K+ E E+
Sbjct: 1615 LRARAEEAEAQKRQAQEEAERLRRQVQD------ESQRKRQAEVELASRVKAEAEAAREK 1668
Query: 576 QNLQKELES--LQNEHAQRMEEFYVEQKDLEKKLE-QIMKQKCTCDSNLE-KDKEAEYAG 631
Q + LE LQ E A+R + Q ++E+ + Q+ + + E + K A +A
Sbjct: 1669 QRALQALEELRLQAEEAERR----LRQAEVERARQVQVALETAQRSAEAELQSKRASFAE 1724
Query: 632 QLAELRQRLDHAEAD----RQELQDELRQEREARQKLEMMIKELKLQILKSSKTAK 683
+ A+L + L R+E + +Q+ EA + E +EL+ LK+++ +
Sbjct: 1725 KTAQLERSLQEEHVAVAQLREEAERRAQQQAEAERAREEAERELERWQLKANEALR 1780
Score = 38.1 bits (87), Expect = 0.027
Identities = 28/140 (20%), Positives = 69/140 (49%), Gaps = 6/140 (4%)
Query: 551 KKQQLQMEVKMLSSSKSMKELTEEQQNLQKELESLQNEHAQRMEEFYVEQKDLEKKLEQI 610
K+ Q +M+ +++ ++ + ++++++Q+EL+ L+ ++ + + E+ +I
Sbjct: 1528 KELQQRMQEEVVRREEAAVDAQQQKRSIQEELQQLRQSSEAEIQAKARQAEAAERSRLRI 1587
Query: 611 MKQKCTCDSNLEKDKEAEYA--GQLAELRQRLDHAEADRQELQDEL----RQEREARQKL 664
++ LE + G+L LR R + AEA +++ Q+E RQ ++ Q+
Sbjct: 1588 EEEIRVVRLQLEATERQRGGAEGELQALRARAEEAEAQKRQAQEEAERLRRQVQDESQRK 1647
Query: 665 EMMIKELKLQILKSSKTAKE 684
EL ++ ++ A+E
Sbjct: 1648 RQAEVELASRVKAEAEAARE 1667
Score = 37.7 bits (86), Expect = 0.035
Identities = 41/161 (25%), Positives = 79/161 (49%), Gaps = 13/161 (8%)
Query: 516 LLVKDVICEDDKGKIMEEVMRTYLKQQEKLNLILQKKQQLQMEVKMLSSSKSMKELTEEQ 575
LL ++ E +K K+ E++ + + + ++L Q++QQ QME + SM+E Q
Sbjct: 2639 LLQRERFIEQEKAKL-EQLFQDEVAKAQQLREEQQRQQQ-QMEQERQRLVASMEEARRRQ 2696
Query: 576 -------QNLQKELESLQNEHAQRMEEFYVEQKDLEKKLEQIMKQKCTCDSNLEKDKEAE 628
+ Q+EL+ L+ + Q+ E E + L ++L+ + +Q ++ E+ ++
Sbjct: 2697 HEAEEGVRRKQEELQQLEQQRRQQEELLAEENQRLREQLQLLEEQHRAALAHSEEVTASQ 2756
Query: 629 YAG--QLAELRQRLD--HAEADRQELQDELRQEREARQKLE 665
A L R LD AEA+ + D LR++ A++ E
Sbjct: 2757 VAATKTLPNGRDALDGPAAEAEPEHSFDGLRRKVSAQRLQE 2797
Score = 35.8 bits (81), Expect = 0.13
Identities = 54/281 (19%), Positives = 116/281 (41%), Gaps = 36/281 (12%)
Query: 416 TSAVSQSKELTKTEASKSISRQSEKAHSSGKLQKTVSYPDVSLEEQEKMDLKTSRELCSR 475
T Q ++L + E ++ Q E A ++ K Q+ + E K+ + L S+
Sbjct: 1859 TEQGEQQRQLLEEELARL---QREAAAATQKRQELEA-------ELAKVRAEMEVLLASK 1908
Query: 476 LDASISNNSTSKRKSE--SATCNLVRDINKVGIGLVAAASSPLLVKDVICEDDKGKIMEE 533
A + STS++ + A R++ + L A A + + E+D + E
Sbjct: 1909 ARAEEESRSTSEKSKQRLEAEAGRFRELAEEAARLRALAEEAKRQRQ-LAEEDAARQRAE 1967
Query: 534 VMRTYLKQQEKLNLILQKKQQLQMEVKMLSS-SKSMKELTEEQQNLQKELESLQNEHAQR 592
R ++ + + K + ++ +K + ++ ++ L E++ ++ LE +H
Sbjct: 1968 AERVLAEKLAAIGEATRLKTEAEIALKEKEAENERLRRLAEDEAFQRRRLEEQAAQH--- 2024
Query: 593 MEEFYVEQKDLEKKLEQIMKQKCTCDSNLEKDK---------EAEYAGQLAELRQRLDHA 643
+ D+E++L Q+ K DS LE+ K + ++ L+ + A
Sbjct: 2025 -------KADIEERLAQLRK---ASDSELERQKGLVEDTLRQRRQVEEEILALKASFEKA 2074
Query: 644 EADRQELQDELRQEREARQKLEMMIKELKLQILKSSKTAKE 684
A + EL+ EL + R + ++ +L+ + + A E
Sbjct: 2075 AAGKAELELELGRIRSNAEDTLRSKEQAELEAARQRQLAAE 2115
Score = 35.0 bits (79), Expect = 0.23
Identities = 81/419 (19%), Positives = 162/419 (38%), Gaps = 86/419 (20%)
Query: 333 QKYLGTPEE--KKLKIILEEMKE-KFSMRSGKRNQSKTDAPSGMELQSWYPVIKQEGDHV 389
QK L EE ++ K LEE++ K + +R + + + S +LQ ++
Sbjct: 2128 QKSLAAEEEAARQRKAALEEVERLKAKVEEARRLRERAEQESARQLQLAQEAAQKRLQAE 2187
Query: 390 SQTHSFLHPSYYLYMCDKVVAPNVSLTSAVSQSKELT-----KTEASKSISRQSEKAHSS 444
+ H+F V L + Q + + + EA++ + ++E+A
Sbjct: 2188 EKAHAFA-----------VQQKEQELQQTLQQEQSVLDQLRGEAEAARRAAEEAEEARVQ 2236
Query: 445 GKLQKTVSYPDVSLEEQEKMDLKTSRELCSRLDASISNNSTSKRKSESATCNLVRDINKV 504
+ + S V EE E++ + +R A + K + A + +
Sbjct: 2237 AEREAAQSRRQV--EEAERLKQSAEEQAQARAQAQAAAEKLRKEAEQEAARRAQAE--QA 2292
Query: 505 GIGLVAAASSPLLVKDVICED---DKGKIMEEVMRTYLKQQE---KLNLILQKKQQL--- 555
+ AA + + E K ++ +E+ L+ +E + NL+ ++ Q+L
Sbjct: 2293 ALRQKQAADAEMEKHKKFAEQTLRQKAQVEQELTTLRLQLEETDHQKNLLDEELQRLKAE 2352
Query: 556 ---------QMEVKMLSSSKSMKELTE-------------------EQQNLQKELESLQN 587
Q+E ++ S M+EL++ Q+ LQ+E E ++
Sbjct: 2353 ATEAARQRSQVEEELFSVRVQMEELSKLKARIEAENRALILRDKDNTQRFLQEEAEKMKQ 2412
Query: 588 --EHAQRMEEFYVEQKDLEKKLEQIMKQKCTCDSNLEKDK------------EAEYAGQL 633
E A R+ E L + E+ + Q+ + K+K EAE Q
Sbjct: 2413 VAEEAARLSVAAQEAARLRQLAEEDLAQQRALAEKMLKEKMQAVQEATRLKAEAELLQQQ 2472
Query: 634 AELRQ-RLDHAEADRQELQDELRQ---------EREARQKLEMM--IKELKLQILKSSK 680
EL Q + + D++++ +L + E E +++LEM + LKL++ + S+
Sbjct: 2473 KELAQEQARRLQEDKEQMAQQLAEETQGFQRTLEAERQRQLEMSAEAERLKLRVAEMSR 2531
Score = 32.0 bits (71), Expect = 1.9
Identities = 34/158 (21%), Positives = 73/158 (46%), Gaps = 24/158 (15%)
Query: 532 EEVMRTY---LKQQEKLNLILQKKQQLQMEVKMLSSSKSMKE-----LTEEQQNLQKELE 583
EEV+R + LK+ + + L + + + +K L + ++ L +E + Q+ E
Sbjct: 1239 EEVLRAHEEQLKEAQAVPATLPELEATKASLKKLRAQAEAQQPTFDALRDELRGAQEVGE 1298
Query: 584 SLQNEHAQR---MEEFYVEQKDLEKKLEQIMKQKCTCDSNLEK-DKEAEYAGQ------- 632
LQ H +R +E + L ++ + ++ Q LE+ ++ Y +
Sbjct: 1299 RLQQRHGERDVEVERWRERVAQLLERWQAVLAQTDVRQRELEQLGRQLRYYRESADPLGA 1358
Query: 633 -LAELRQRLDHAEA----DRQELQDELRQEREARQKLE 665
L + R+R + +A D Q ++++LRQE+ +++E
Sbjct: 1359 WLQDARRRQEQIQAMPLADSQAVREQLRQEQALLEEIE 1396
>gi|41322908 plectin 1 isoform 3 [Homo sapiens]
Length = 4525
Score = 56.6 bits (135), Expect = 7e-08
Identities = 59/270 (21%), Positives = 123/270 (45%), Gaps = 29/270 (10%)
Query: 419 VSQSKELTKTEASKSISRQSEKAHSSGKLQKTVSYPDVSLEEQEKMDLKTSRELCSRLDA 478
+ Q KEL + +A + Q +K + +L + +LE + + L+ S E RL
Sbjct: 2310 LQQQKELAQEQARRL---QEDKEQMAQQLAEETQGFQRTLEAERQRQLEMSAE-AERLKL 2365
Query: 479 SISNNSTSKRKSESATCNLVRDINKVGIGL----VAAASSPLLVKDVICEDDKGKIMEEV 534
++ S ++ ++E + ++G L +A LV+ + + + E
Sbjct: 2366 RVAEMSRAQARAEEDAQRFRKQAEEIGEKLHRTELATQEKVTLVQTLEIQRQQSDHDAER 2425
Query: 535 MRTYLKQQEKLNLILQKKQQLQMEVKMLSSSKSMKELTEEQQNLQKELESLQNEHAQRME 594
+R + + E+ +K++LQ E K+L KS + T +Q+ L +E ++LQ +
Sbjct: 2426 LREAIAELER------EKEKLQQEAKLLQL-KSEEMQTVQQEQLLQETQALQQSFLSEKD 2478
Query: 595 EFYVEQKDLEK---KLEQIMKQKCTCDSNLEKDKEAEY----------AGQLAELRQRLD 641
++ +E+ KLEQ+ + + L ++++ + + E R+R
Sbjct: 2479 SLLQRERFIEQEKAKLEQLFQDEVAKAQQLREEQQRQQQQMEQERQRLVASMEEARRRQH 2538
Query: 642 HAEADRQELQDELRQ-EREARQKLEMMIKE 670
AE + Q+EL+Q E++ RQ+ E++ +E
Sbjct: 2539 EAEEGVRRKQEELQQLEQQRRQQEELLAEE 2568
Score = 52.4 bits (124), Expect = 1e-06
Identities = 68/284 (23%), Positives = 126/284 (44%), Gaps = 34/284 (11%)
Query: 420 SQSKELTKTEASKSISRQSEKAHSSGKLQKTVSYPDVSLEEQEKM----DLKTSRELCSR 475
SQ K + E + + ++E A + + + + EE E+ +++ +R++
Sbjct: 1485 SQRKRQAEVELASRVKAEAEAAREKQRALQALEELRLQAEEAERRLRQAEVERARQVQVA 1544
Query: 476 LDA---SISNNSTSKRKS-ESATCNLVRDINK--VGIGLVAAASSPLLVKDVICEDDKGK 529
L+ S SKR S T L R + + V + + + + E + +
Sbjct: 1545 LETAQRSAEAELQSKRASFAEKTAQLERSLQEEHVAVAQLREEAERRAQQQAEAERAREE 1604
Query: 530 IMEEVMRTYLKQQEKLNLILQKKQQLQMEVKMLSSSKSMKELTEEQQNLQKELESLQNEH 589
E+ R LK E L L LQ ++ Q KS+ + E+Q + E E+ +
Sbjct: 1605 AERELERWQLKANEALRLRLQAEEVAQQ--------KSLAQAEAEKQKEEAEREARRRGK 1656
Query: 590 AQRMEEFYVEQKDLEKKLEQIMKQKCTCDSNLEKDKEAEYAGQLAELRQRLDHAEADRQE 649
A EE V Q++L + +++ KQ+ + ++ AE +L LR + E RQ
Sbjct: 1657 A---EEQAVRQRELAE--QELEKQRQLAEGTAQQRLAAEQ--ELIRLRAETEQGEQQRQL 1709
Query: 650 LQDEL-RQEREA------RQKLEMMIKELK--LQILKSSKTAKE 684
L++EL R +REA RQ+LE + +++ +++L +SK E
Sbjct: 1710 LEEELARLQREAAAATQKRQELEAELAKVRAEMEVLLASKARAE 1753
Score = 44.3 bits (103), Expect = 4e-04
Identities = 65/296 (21%), Positives = 123/296 (41%), Gaps = 43/296 (14%)
Query: 421 QSKELTKTEASKSISRQSEKAHSSGK---------LQKTVSYPDVSLEE------QEKMD 465
+ + L + EA+ RQ +AH+ K LQ+ + V EE Q+K
Sbjct: 1336 ERERLAEVEAALEKQRQLAEAHAQAKAQAEREAKELQQRMQEEVVRREEAAVDAQQQKRS 1395
Query: 466 LKTS-RELCSRLDASISNNSTSKRKSESATCNLVRDINKVGIGLVAAAS---------SP 515
++ ++L +A I + +E + + +I V + L A
Sbjct: 1396 IQEELQQLRQSSEAEIQAKARQAEAAERSRLRIEEEIRVVRLQLEATERQRGGAEGELQA 1455
Query: 516 LLVKDVICEDDKGKIMEEVMRTYLKQQEKLNLILQKKQQLQMEVKMLSSSKSMKELTEEQ 575
L + E K + EE R + Q+ + +++ Q EV++ S K+ E E+
Sbjct: 1456 LRARAEEAEAQKRQAQEEAERLRRQVQD------ESQRKRQAEVELASRVKAEAEAAREK 1509
Query: 576 QNLQKELES--LQNEHAQRMEEFYVEQKDLEKKLE-QIMKQKCTCDSNLE-KDKEAEYAG 631
Q + LE LQ E A+R + Q ++E+ + Q+ + + E + K A +A
Sbjct: 1510 QRALQALEELRLQAEEAERR----LRQAEVERARQVQVALETAQRSAEAELQSKRASFAE 1565
Query: 632 QLAELRQRLDHAEAD----RQELQDELRQEREARQKLEMMIKELKLQILKSSKTAK 683
+ A+L + L R+E + +Q+ EA + E +EL+ LK+++ +
Sbjct: 1566 KTAQLERSLQEEHVAVAQLREEAERRAQQQAEAERAREEAERELERWQLKANEALR 1621
Score = 38.1 bits (87), Expect = 0.027
Identities = 28/140 (20%), Positives = 69/140 (49%), Gaps = 6/140 (4%)
Query: 551 KKQQLQMEVKMLSSSKSMKELTEEQQNLQKELESLQNEHAQRMEEFYVEQKDLEKKLEQI 610
K+ Q +M+ +++ ++ + ++++++Q+EL+ L+ ++ + + E+ +I
Sbjct: 1369 KELQQRMQEEVVRREEAAVDAQQQKRSIQEELQQLRQSSEAEIQAKARQAEAAERSRLRI 1428
Query: 611 MKQKCTCDSNLEKDKEAEYA--GQLAELRQRLDHAEADRQELQDEL----RQEREARQKL 664
++ LE + G+L LR R + AEA +++ Q+E RQ ++ Q+
Sbjct: 1429 EEEIRVVRLQLEATERQRGGAEGELQALRARAEEAEAQKRQAQEEAERLRRQVQDESQRK 1488
Query: 665 EMMIKELKLQILKSSKTAKE 684
EL ++ ++ A+E
Sbjct: 1489 RQAEVELASRVKAEAEAARE 1508
Score = 37.7 bits (86), Expect = 0.035
Identities = 41/161 (25%), Positives = 79/161 (49%), Gaps = 13/161 (8%)
Query: 516 LLVKDVICEDDKGKIMEEVMRTYLKQQEKLNLILQKKQQLQMEVKMLSSSKSMKELTEEQ 575
LL ++ E +K K+ E++ + + + ++L Q++QQ QME + SM+E Q
Sbjct: 2480 LLQRERFIEQEKAKL-EQLFQDEVAKAQQLREEQQRQQQ-QMEQERQRLVASMEEARRRQ 2537
Query: 576 -------QNLQKELESLQNEHAQRMEEFYVEQKDLEKKLEQIMKQKCTCDSNLEKDKEAE 628
+ Q+EL+ L+ + Q+ E E + L ++L+ + +Q ++ E+ ++
Sbjct: 2538 HEAEEGVRRKQEELQQLEQQRRQQEELLAEENQRLREQLQLLEEQHRAALAHSEEVTASQ 2597
Query: 629 YAG--QLAELRQRLD--HAEADRQELQDELRQEREARQKLE 665
A L R LD AEA+ + D LR++ A++ E
Sbjct: 2598 VAATKTLPNGRDALDGPAAEAEPEHSFDGLRRKVSAQRLQE 2638
Score = 35.8 bits (81), Expect = 0.13
Identities = 54/281 (19%), Positives = 116/281 (41%), Gaps = 36/281 (12%)
Query: 416 TSAVSQSKELTKTEASKSISRQSEKAHSSGKLQKTVSYPDVSLEEQEKMDLKTSRELCSR 475
T Q ++L + E ++ Q E A ++ K Q+ + E K+ + L S+
Sbjct: 1700 TEQGEQQRQLLEEELARL---QREAAAATQKRQELEA-------ELAKVRAEMEVLLASK 1749
Query: 476 LDASISNNSTSKRKSE--SATCNLVRDINKVGIGLVAAASSPLLVKDVICEDDKGKIMEE 533
A + STS++ + A R++ + L A A + + E+D + E
Sbjct: 1750 ARAEEESRSTSEKSKQRLEAEAGRFRELAEEAARLRALAEEAKRQRQ-LAEEDAARQRAE 1808
Query: 534 VMRTYLKQQEKLNLILQKKQQLQMEVKMLSS-SKSMKELTEEQQNLQKELESLQNEHAQR 592
R ++ + + K + ++ +K + ++ ++ L E++ ++ LE +H
Sbjct: 1809 AERVLAEKLAAIGEATRLKTEAEIALKEKEAENERLRRLAEDEAFQRRRLEEQAAQH--- 1865
Query: 593 MEEFYVEQKDLEKKLEQIMKQKCTCDSNLEKDK---------EAEYAGQLAELRQRLDHA 643
+ D+E++L Q+ K DS LE+ K + ++ L+ + A
Sbjct: 1866 -------KADIEERLAQLRK---ASDSELERQKGLVEDTLRQRRQVEEEILALKASFEKA 1915
Query: 644 EADRQELQDELRQEREARQKLEMMIKELKLQILKSSKTAKE 684
A + EL+ EL + R + ++ +L+ + + A E
Sbjct: 1916 AAGKAELELELGRIRSNAEDTLRSKEQAELEAARQRQLAAE 1956
Score = 35.0 bits (79), Expect = 0.23
Identities = 81/419 (19%), Positives = 162/419 (38%), Gaps = 86/419 (20%)
Query: 333 QKYLGTPEE--KKLKIILEEMKE-KFSMRSGKRNQSKTDAPSGMELQSWYPVIKQEGDHV 389
QK L EE ++ K LEE++ K + +R + + + S +LQ ++
Sbjct: 1969 QKSLAAEEEAARQRKAALEEVERLKAKVEEARRLRERAEQESARQLQLAQEAAQKRLQAE 2028
Query: 390 SQTHSFLHPSYYLYMCDKVVAPNVSLTSAVSQSKELT-----KTEASKSISRQSEKAHSS 444
+ H+F V L + Q + + + EA++ + ++E+A
Sbjct: 2029 EKAHAFA-----------VQQKEQELQQTLQQEQSVLDQLRGEAEAARRAAEEAEEARVQ 2077
Query: 445 GKLQKTVSYPDVSLEEQEKMDLKTSRELCSRLDASISNNSTSKRKSESATCNLVRDINKV 504
+ + S V EE E++ + +R A + K + A + +
Sbjct: 2078 AEREAAQSRRQV--EEAERLKQSAEEQAQARAQAQAAAEKLRKEAEQEAARRAQAE--QA 2133
Query: 505 GIGLVAAASSPLLVKDVICED---DKGKIMEEVMRTYLKQQE---KLNLILQKKQQL--- 555
+ AA + + E K ++ +E+ L+ +E + NL+ ++ Q+L
Sbjct: 2134 ALRQKQAADAEMEKHKKFAEQTLRQKAQVEQELTTLRLQLEETDHQKNLLDEELQRLKAE 2193
Query: 556 ---------QMEVKMLSSSKSMKELTE-------------------EQQNLQKELESLQN 587
Q+E ++ S M+EL++ Q+ LQ+E E ++
Sbjct: 2194 ATEAARQRSQVEEELFSVRVQMEELSKLKARIEAENRALILRDKDNTQRFLQEEAEKMKQ 2253
Query: 588 --EHAQRMEEFYVEQKDLEKKLEQIMKQKCTCDSNLEKDK------------EAEYAGQL 633
E A R+ E L + E+ + Q+ + K+K EAE Q
Sbjct: 2254 VAEEAARLSVAAQEAARLRQLAEEDLAQQRALAEKMLKEKMQAVQEATRLKAEAELLQQQ 2313
Query: 634 AELRQ-RLDHAEADRQELQDELRQ---------EREARQKLEMM--IKELKLQILKSSK 680
EL Q + + D++++ +L + E E +++LEM + LKL++ + S+
Sbjct: 2314 KELAQEQARRLQEDKEQMAQQLAEETQGFQRTLEAERQRQLEMSAEAERLKLRVAEMSR 2372
Score = 32.0 bits (71), Expect = 1.9
Identities = 34/158 (21%), Positives = 73/158 (46%), Gaps = 24/158 (15%)
Query: 532 EEVMRTY---LKQQEKLNLILQKKQQLQMEVKMLSSSKSMKE-----LTEEQQNLQKELE 583
EEV+R + LK+ + + L + + + +K L + ++ L +E + Q+ E
Sbjct: 1080 EEVLRAHEEQLKEAQAVPATLPELEATKASLKKLRAQAEAQQPTFDALRDELRGAQEVGE 1139
Query: 584 SLQNEHAQR---MEEFYVEQKDLEKKLEQIMKQKCTCDSNLEK-DKEAEYAGQ------- 632
LQ H +R +E + L ++ + ++ Q LE+ ++ Y +
Sbjct: 1140 RLQQRHGERDVEVERWRERVAQLLERWQAVLAQTDVRQRELEQLGRQLRYYRESADPLGA 1199
Query: 633 -LAELRQRLDHAEA----DRQELQDELRQEREARQKLE 665
L + R+R + +A D Q ++++LRQE+ +++E
Sbjct: 1200 WLQDARRRQEQIQAMPLADSQAVREQLRQEQALLEEIE 1237
>gi|41322912 plectin 1 isoform 2 [Homo sapiens]
Length = 4533
Score = 56.6 bits (135), Expect = 7e-08
Identities = 59/270 (21%), Positives = 123/270 (45%), Gaps = 29/270 (10%)
Query: 419 VSQSKELTKTEASKSISRQSEKAHSSGKLQKTVSYPDVSLEEQEKMDLKTSRELCSRLDA 478
+ Q KEL + +A + Q +K + +L + +LE + + L+ S E RL
Sbjct: 2318 LQQQKELAQEQARRL---QEDKEQMAQQLAEETQGFQRTLEAERQRQLEMSAE-AERLKL 2373
Query: 479 SISNNSTSKRKSESATCNLVRDINKVGIGL----VAAASSPLLVKDVICEDDKGKIMEEV 534
++ S ++ ++E + ++G L +A LV+ + + + E
Sbjct: 2374 RVAEMSRAQARAEEDAQRFRKQAEEIGEKLHRTELATQEKVTLVQTLEIQRQQSDHDAER 2433
Query: 535 MRTYLKQQEKLNLILQKKQQLQMEVKMLSSSKSMKELTEEQQNLQKELESLQNEHAQRME 594
+R + + E+ +K++LQ E K+L KS + T +Q+ L +E ++LQ +
Sbjct: 2434 LREAIAELER------EKEKLQQEAKLLQL-KSEEMQTVQQEQLLQETQALQQSFLSEKD 2486
Query: 595 EFYVEQKDLEK---KLEQIMKQKCTCDSNLEKDKEAEY----------AGQLAELRQRLD 641
++ +E+ KLEQ+ + + L ++++ + + E R+R
Sbjct: 2487 SLLQRERFIEQEKAKLEQLFQDEVAKAQQLREEQQRQQQQMEQERQRLVASMEEARRRQH 2546
Query: 642 HAEADRQELQDELRQ-EREARQKLEMMIKE 670
AE + Q+EL+Q E++ RQ+ E++ +E
Sbjct: 2547 EAEEGVRRKQEELQQLEQQRRQQEELLAEE 2576
Score = 52.4 bits (124), Expect = 1e-06
Identities = 68/284 (23%), Positives = 126/284 (44%), Gaps = 34/284 (11%)
Query: 420 SQSKELTKTEASKSISRQSEKAHSSGKLQKTVSYPDVSLEEQEKM----DLKTSRELCSR 475
SQ K + E + + ++E A + + + + EE E+ +++ +R++
Sbjct: 1493 SQRKRQAEVELASRVKAEAEAAREKQRALQALEELRLQAEEAERRLRQAEVERARQVQVA 1552
Query: 476 LDA---SISNNSTSKRKS-ESATCNLVRDINK--VGIGLVAAASSPLLVKDVICEDDKGK 529
L+ S SKR S T L R + + V + + + + E + +
Sbjct: 1553 LETAQRSAEAELQSKRASFAEKTAQLERSLQEEHVAVAQLREEAERRAQQQAEAERAREE 1612
Query: 530 IMEEVMRTYLKQQEKLNLILQKKQQLQMEVKMLSSSKSMKELTEEQQNLQKELESLQNEH 589
E+ R LK E L L LQ ++ Q KS+ + E+Q + E E+ +
Sbjct: 1613 AERELERWQLKANEALRLRLQAEEVAQQ--------KSLAQAEAEKQKEEAEREARRRGK 1664
Query: 590 AQRMEEFYVEQKDLEKKLEQIMKQKCTCDSNLEKDKEAEYAGQLAELRQRLDHAEADRQE 649
A EE V Q++L + +++ KQ+ + ++ AE +L LR + E RQ
Sbjct: 1665 A---EEQAVRQRELAE--QELEKQRQLAEGTAQQRLAAEQ--ELIRLRAETEQGEQQRQL 1717
Query: 650 LQDEL-RQEREA------RQKLEMMIKELK--LQILKSSKTAKE 684
L++EL R +REA RQ+LE + +++ +++L +SK E
Sbjct: 1718 LEEELARLQREAAAATQKRQELEAELAKVRAEMEVLLASKARAE 1761
Score = 44.3 bits (103), Expect = 4e-04
Identities = 65/296 (21%), Positives = 123/296 (41%), Gaps = 43/296 (14%)
Query: 421 QSKELTKTEASKSISRQSEKAHSSGK---------LQKTVSYPDVSLEE------QEKMD 465
+ + L + EA+ RQ +AH+ K LQ+ + V EE Q+K
Sbjct: 1344 ERERLAEVEAALEKQRQLAEAHAQAKAQAEREAKELQQRMQEEVVRREEAAVDAQQQKRS 1403
Query: 466 LKTS-RELCSRLDASISNNSTSKRKSESATCNLVRDINKVGIGLVAAAS---------SP 515
++ ++L +A I + +E + + +I V + L A
Sbjct: 1404 IQEELQQLRQSSEAEIQAKARQAEAAERSRLRIEEEIRVVRLQLEATERQRGGAEGELQA 1463
Query: 516 LLVKDVICEDDKGKIMEEVMRTYLKQQEKLNLILQKKQQLQMEVKMLSSSKSMKELTEEQ 575
L + E K + EE R + Q+ + +++ Q EV++ S K+ E E+
Sbjct: 1464 LRARAEEAEAQKRQAQEEAERLRRQVQD------ESQRKRQAEVELASRVKAEAEAAREK 1517
Query: 576 QNLQKELES--LQNEHAQRMEEFYVEQKDLEKKLE-QIMKQKCTCDSNLE-KDKEAEYAG 631
Q + LE LQ E A+R + Q ++E+ + Q+ + + E + K A +A
Sbjct: 1518 QRALQALEELRLQAEEAERR----LRQAEVERARQVQVALETAQRSAEAELQSKRASFAE 1573
Query: 632 QLAELRQRLDHAEAD----RQELQDELRQEREARQKLEMMIKELKLQILKSSKTAK 683
+ A+L + L R+E + +Q+ EA + E +EL+ LK+++ +
Sbjct: 1574 KTAQLERSLQEEHVAVAQLREEAERRAQQQAEAERAREEAERELERWQLKANEALR 1629
Score = 38.1 bits (87), Expect = 0.027
Identities = 28/140 (20%), Positives = 69/140 (49%), Gaps = 6/140 (4%)
Query: 551 KKQQLQMEVKMLSSSKSMKELTEEQQNLQKELESLQNEHAQRMEEFYVEQKDLEKKLEQI 610
K+ Q +M+ +++ ++ + ++++++Q+EL+ L+ ++ + + E+ +I
Sbjct: 1377 KELQQRMQEEVVRREEAAVDAQQQKRSIQEELQQLRQSSEAEIQAKARQAEAAERSRLRI 1436
Query: 611 MKQKCTCDSNLEKDKEAEYA--GQLAELRQRLDHAEADRQELQDEL----RQEREARQKL 664
++ LE + G+L LR R + AEA +++ Q+E RQ ++ Q+
Sbjct: 1437 EEEIRVVRLQLEATERQRGGAEGELQALRARAEEAEAQKRQAQEEAERLRRQVQDESQRK 1496
Query: 665 EMMIKELKLQILKSSKTAKE 684
EL ++ ++ A+E
Sbjct: 1497 RQAEVELASRVKAEAEAARE 1516
Score = 37.7 bits (86), Expect = 0.035
Identities = 41/161 (25%), Positives = 79/161 (49%), Gaps = 13/161 (8%)
Query: 516 LLVKDVICEDDKGKIMEEVMRTYLKQQEKLNLILQKKQQLQMEVKMLSSSKSMKELTEEQ 575
LL ++ E +K K+ E++ + + + ++L Q++QQ QME + SM+E Q
Sbjct: 2488 LLQRERFIEQEKAKL-EQLFQDEVAKAQQLREEQQRQQQ-QMEQERQRLVASMEEARRRQ 2545
Query: 576 -------QNLQKELESLQNEHAQRMEEFYVEQKDLEKKLEQIMKQKCTCDSNLEKDKEAE 628
+ Q+EL+ L+ + Q+ E E + L ++L+ + +Q ++ E+ ++
Sbjct: 2546 HEAEEGVRRKQEELQQLEQQRRQQEELLAEENQRLREQLQLLEEQHRAALAHSEEVTASQ 2605
Query: 629 YAG--QLAELRQRLD--HAEADRQELQDELRQEREARQKLE 665
A L R LD AEA+ + D LR++ A++ E
Sbjct: 2606 VAATKTLPNGRDALDGPAAEAEPEHSFDGLRRKVSAQRLQE 2646
Score = 35.8 bits (81), Expect = 0.13
Identities = 54/281 (19%), Positives = 116/281 (41%), Gaps = 36/281 (12%)
Query: 416 TSAVSQSKELTKTEASKSISRQSEKAHSSGKLQKTVSYPDVSLEEQEKMDLKTSRELCSR 475
T Q ++L + E ++ Q E A ++ K Q+ + E K+ + L S+
Sbjct: 1708 TEQGEQQRQLLEEELARL---QREAAAATQKRQELEA-------ELAKVRAEMEVLLASK 1757
Query: 476 LDASISNNSTSKRKSE--SATCNLVRDINKVGIGLVAAASSPLLVKDVICEDDKGKIMEE 533
A + STS++ + A R++ + L A A + + E+D + E
Sbjct: 1758 ARAEEESRSTSEKSKQRLEAEAGRFRELAEEAARLRALAEEAKRQRQ-LAEEDAARQRAE 1816
Query: 534 VMRTYLKQQEKLNLILQKKQQLQMEVKMLSS-SKSMKELTEEQQNLQKELESLQNEHAQR 592
R ++ + + K + ++ +K + ++ ++ L E++ ++ LE +H
Sbjct: 1817 AERVLAEKLAAIGEATRLKTEAEIALKEKEAENERLRRLAEDEAFQRRRLEEQAAQH--- 1873
Query: 593 MEEFYVEQKDLEKKLEQIMKQKCTCDSNLEKDK---------EAEYAGQLAELRQRLDHA 643
+ D+E++L Q+ K DS LE+ K + ++ L+ + A
Sbjct: 1874 -------KADIEERLAQLRK---ASDSELERQKGLVEDTLRQRRQVEEEILALKASFEKA 1923
Query: 644 EADRQELQDELRQEREARQKLEMMIKELKLQILKSSKTAKE 684
A + EL+ EL + R + ++ +L+ + + A E
Sbjct: 1924 AAGKAELELELGRIRSNAEDTLRSKEQAELEAARQRQLAAE 1964
Score = 35.0 bits (79), Expect = 0.23
Identities = 81/419 (19%), Positives = 162/419 (38%), Gaps = 86/419 (20%)
Query: 333 QKYLGTPEE--KKLKIILEEMKE-KFSMRSGKRNQSKTDAPSGMELQSWYPVIKQEGDHV 389
QK L EE ++ K LEE++ K + +R + + + S +LQ ++
Sbjct: 1977 QKSLAAEEEAARQRKAALEEVERLKAKVEEARRLRERAEQESARQLQLAQEAAQKRLQAE 2036
Query: 390 SQTHSFLHPSYYLYMCDKVVAPNVSLTSAVSQSKELT-----KTEASKSISRQSEKAHSS 444
+ H+F V L + Q + + + EA++ + ++E+A
Sbjct: 2037 EKAHAFA-----------VQQKEQELQQTLQQEQSVLDQLRGEAEAARRAAEEAEEARVQ 2085
Query: 445 GKLQKTVSYPDVSLEEQEKMDLKTSRELCSRLDASISNNSTSKRKSESATCNLVRDINKV 504
+ + S V EE E++ + +R A + K + A + +
Sbjct: 2086 AEREAAQSRRQV--EEAERLKQSAEEQAQARAQAQAAAEKLRKEAEQEAARRAQAE--QA 2141
Query: 505 GIGLVAAASSPLLVKDVICED---DKGKIMEEVMRTYLKQQE---KLNLILQKKQQL--- 555
+ AA + + E K ++ +E+ L+ +E + NL+ ++ Q+L
Sbjct: 2142 ALRQKQAADAEMEKHKKFAEQTLRQKAQVEQELTTLRLQLEETDHQKNLLDEELQRLKAE 2201
Query: 556 ---------QMEVKMLSSSKSMKELTE-------------------EQQNLQKELESLQN 587
Q+E ++ S M+EL++ Q+ LQ+E E ++
Sbjct: 2202 ATEAARQRSQVEEELFSVRVQMEELSKLKARIEAENRALILRDKDNTQRFLQEEAEKMKQ 2261
Query: 588 --EHAQRMEEFYVEQKDLEKKLEQIMKQKCTCDSNLEKDK------------EAEYAGQL 633
E A R+ E L + E+ + Q+ + K+K EAE Q
Sbjct: 2262 VAEEAARLSVAAQEAARLRQLAEEDLAQQRALAEKMLKEKMQAVQEATRLKAEAELLQQQ 2321
Query: 634 AELRQ-RLDHAEADRQELQDELRQ---------EREARQKLEMM--IKELKLQILKSSK 680
EL Q + + D++++ +L + E E +++LEM + LKL++ + S+
Sbjct: 2322 KELAQEQARRLQEDKEQMAQQLAEETQGFQRTLEAERQRQLEMSAEAERLKLRVAEMSR 2380
Score = 32.0 bits (71), Expect = 1.9
Identities = 34/158 (21%), Positives = 73/158 (46%), Gaps = 24/158 (15%)
Query: 532 EEVMRTY---LKQQEKLNLILQKKQQLQMEVKMLSSSKSMKE-----LTEEQQNLQKELE 583
EEV+R + LK+ + + L + + + +K L + ++ L +E + Q+ E
Sbjct: 1088 EEVLRAHEEQLKEAQAVPATLPELEATKASLKKLRAQAEAQQPTFDALRDELRGAQEVGE 1147
Query: 584 SLQNEHAQR---MEEFYVEQKDLEKKLEQIMKQKCTCDSNLEK-DKEAEYAGQ------- 632
LQ H +R +E + L ++ + ++ Q LE+ ++ Y +
Sbjct: 1148 RLQQRHGERDVEVERWRERVAQLLERWQAVLAQTDVRQRELEQLGRQLRYYRESADPLGA 1207
Query: 633 -LAELRQRLDHAEA----DRQELQDELRQEREARQKLE 665
L + R+R + +A D Q ++++LRQE+ +++E
Sbjct: 1208 WLQDARRRQEQIQAMPLADSQAVREQLRQEQALLEEIE 1245
>gi|47607492 plectin 1 isoform 1 [Homo sapiens]
Length = 4574
Score = 56.6 bits (135), Expect = 7e-08
Identities = 59/270 (21%), Positives = 123/270 (45%), Gaps = 29/270 (10%)
Query: 419 VSQSKELTKTEASKSISRQSEKAHSSGKLQKTVSYPDVSLEEQEKMDLKTSRELCSRLDA 478
+ Q KEL + +A + Q +K + +L + +LE + + L+ S E RL
Sbjct: 2359 LQQQKELAQEQARRL---QEDKEQMAQQLAEETQGFQRTLEAERQRQLEMSAE-AERLKL 2414
Query: 479 SISNNSTSKRKSESATCNLVRDINKVGIGL----VAAASSPLLVKDVICEDDKGKIMEEV 534
++ S ++ ++E + ++G L +A LV+ + + + E
Sbjct: 2415 RVAEMSRAQARAEEDAQRFRKQAEEIGEKLHRTELATQEKVTLVQTLEIQRQQSDHDAER 2474
Query: 535 MRTYLKQQEKLNLILQKKQQLQMEVKMLSSSKSMKELTEEQQNLQKELESLQNEHAQRME 594
+R + + E+ +K++LQ E K+L KS + T +Q+ L +E ++LQ +
Sbjct: 2475 LREAIAELER------EKEKLQQEAKLLQL-KSEEMQTVQQEQLLQETQALQQSFLSEKD 2527
Query: 595 EFYVEQKDLEK---KLEQIMKQKCTCDSNLEKDKEAEY----------AGQLAELRQRLD 641
++ +E+ KLEQ+ + + L ++++ + + E R+R
Sbjct: 2528 SLLQRERFIEQEKAKLEQLFQDEVAKAQQLREEQQRQQQQMEQERQRLVASMEEARRRQH 2587
Query: 642 HAEADRQELQDELRQ-EREARQKLEMMIKE 670
AE + Q+EL+Q E++ RQ+ E++ +E
Sbjct: 2588 EAEEGVRRKQEELQQLEQQRRQQEELLAEE 2617
Score = 52.4 bits (124), Expect = 1e-06
Identities = 68/284 (23%), Positives = 126/284 (44%), Gaps = 34/284 (11%)
Query: 420 SQSKELTKTEASKSISRQSEKAHSSGKLQKTVSYPDVSLEEQEKM----DLKTSRELCSR 475
SQ K + E + + ++E A + + + + EE E+ +++ +R++
Sbjct: 1534 SQRKRQAEVELASRVKAEAEAAREKQRALQALEELRLQAEEAERRLRQAEVERARQVQVA 1593
Query: 476 LDA---SISNNSTSKRKS-ESATCNLVRDINK--VGIGLVAAASSPLLVKDVICEDDKGK 529
L+ S SKR S T L R + + V + + + + E + +
Sbjct: 1594 LETAQRSAEAELQSKRASFAEKTAQLERSLQEEHVAVAQLREEAERRAQQQAEAERAREE 1653
Query: 530 IMEEVMRTYLKQQEKLNLILQKKQQLQMEVKMLSSSKSMKELTEEQQNLQKELESLQNEH 589
E+ R LK E L L LQ ++ Q KS+ + E+Q + E E+ +
Sbjct: 1654 AERELERWQLKANEALRLRLQAEEVAQQ--------KSLAQAEAEKQKEEAEREARRRGK 1705
Query: 590 AQRMEEFYVEQKDLEKKLEQIMKQKCTCDSNLEKDKEAEYAGQLAELRQRLDHAEADRQE 649
A EE V Q++L + +++ KQ+ + ++ AE +L LR + E RQ
Sbjct: 1706 A---EEQAVRQRELAE--QELEKQRQLAEGTAQQRLAAEQ--ELIRLRAETEQGEQQRQL 1758
Query: 650 LQDEL-RQEREA------RQKLEMMIKELK--LQILKSSKTAKE 684
L++EL R +REA RQ+LE + +++ +++L +SK E
Sbjct: 1759 LEEELARLQREAAAATQKRQELEAELAKVRAEMEVLLASKARAE 1802
Score = 44.3 bits (103), Expect = 4e-04
Identities = 65/296 (21%), Positives = 123/296 (41%), Gaps = 43/296 (14%)
Query: 421 QSKELTKTEASKSISRQSEKAHSSGK---------LQKTVSYPDVSLEE------QEKMD 465
+ + L + EA+ RQ +AH+ K LQ+ + V EE Q+K
Sbjct: 1385 ERERLAEVEAALEKQRQLAEAHAQAKAQAEREAKELQQRMQEEVVRREEAAVDAQQQKRS 1444
Query: 466 LKTS-RELCSRLDASISNNSTSKRKSESATCNLVRDINKVGIGLVAAAS---------SP 515
++ ++L +A I + +E + + +I V + L A
Sbjct: 1445 IQEELQQLRQSSEAEIQAKARQAEAAERSRLRIEEEIRVVRLQLEATERQRGGAEGELQA 1504
Query: 516 LLVKDVICEDDKGKIMEEVMRTYLKQQEKLNLILQKKQQLQMEVKMLSSSKSMKELTEEQ 575
L + E K + EE R + Q+ + +++ Q EV++ S K+ E E+
Sbjct: 1505 LRARAEEAEAQKRQAQEEAERLRRQVQD------ESQRKRQAEVELASRVKAEAEAAREK 1558
Query: 576 QNLQKELES--LQNEHAQRMEEFYVEQKDLEKKLE-QIMKQKCTCDSNLE-KDKEAEYAG 631
Q + LE LQ E A+R + Q ++E+ + Q+ + + E + K A +A
Sbjct: 1559 QRALQALEELRLQAEEAERR----LRQAEVERARQVQVALETAQRSAEAELQSKRASFAE 1614
Query: 632 QLAELRQRLDHAEAD----RQELQDELRQEREARQKLEMMIKELKLQILKSSKTAK 683
+ A+L + L R+E + +Q+ EA + E +EL+ LK+++ +
Sbjct: 1615 KTAQLERSLQEEHVAVAQLREEAERRAQQQAEAERAREEAERELERWQLKANEALR 1670
Score = 38.1 bits (87), Expect = 0.027
Identities = 28/140 (20%), Positives = 69/140 (49%), Gaps = 6/140 (4%)
Query: 551 KKQQLQMEVKMLSSSKSMKELTEEQQNLQKELESLQNEHAQRMEEFYVEQKDLEKKLEQI 610
K+ Q +M+ +++ ++ + ++++++Q+EL+ L+ ++ + + E+ +I
Sbjct: 1418 KELQQRMQEEVVRREEAAVDAQQQKRSIQEELQQLRQSSEAEIQAKARQAEAAERSRLRI 1477
Query: 611 MKQKCTCDSNLEKDKEAEYA--GQLAELRQRLDHAEADRQELQDEL----RQEREARQKL 664
++ LE + G+L LR R + AEA +++ Q+E RQ ++ Q+
Sbjct: 1478 EEEIRVVRLQLEATERQRGGAEGELQALRARAEEAEAQKRQAQEEAERLRRQVQDESQRK 1537
Query: 665 EMMIKELKLQILKSSKTAKE 684
EL ++ ++ A+E
Sbjct: 1538 RQAEVELASRVKAEAEAARE 1557
Score = 37.7 bits (86), Expect = 0.035
Identities = 41/161 (25%), Positives = 79/161 (49%), Gaps = 13/161 (8%)
Query: 516 LLVKDVICEDDKGKIMEEVMRTYLKQQEKLNLILQKKQQLQMEVKMLSSSKSMKELTEEQ 575
LL ++ E +K K+ E++ + + + ++L Q++QQ QME + SM+E Q
Sbjct: 2529 LLQRERFIEQEKAKL-EQLFQDEVAKAQQLREEQQRQQQ-QMEQERQRLVASMEEARRRQ 2586
Query: 576 -------QNLQKELESLQNEHAQRMEEFYVEQKDLEKKLEQIMKQKCTCDSNLEKDKEAE 628
+ Q+EL+ L+ + Q+ E E + L ++L+ + +Q ++ E+ ++
Sbjct: 2587 HEAEEGVRRKQEELQQLEQQRRQQEELLAEENQRLREQLQLLEEQHRAALAHSEEVTASQ 2646
Query: 629 YAG--QLAELRQRLD--HAEADRQELQDELRQEREARQKLE 665
A L R LD AEA+ + D LR++ A++ E
Sbjct: 2647 VAATKTLPNGRDALDGPAAEAEPEHSFDGLRRKVSAQRLQE 2687
Score = 35.8 bits (81), Expect = 0.13
Identities = 54/281 (19%), Positives = 116/281 (41%), Gaps = 36/281 (12%)
Query: 416 TSAVSQSKELTKTEASKSISRQSEKAHSSGKLQKTVSYPDVSLEEQEKMDLKTSRELCSR 475
T Q ++L + E ++ Q E A ++ K Q+ + E K+ + L S+
Sbjct: 1749 TEQGEQQRQLLEEELARL---QREAAAATQKRQELEA-------ELAKVRAEMEVLLASK 1798
Query: 476 LDASISNNSTSKRKSE--SATCNLVRDINKVGIGLVAAASSPLLVKDVICEDDKGKIMEE 533
A + STS++ + A R++ + L A A + + E+D + E
Sbjct: 1799 ARAEEESRSTSEKSKQRLEAEAGRFRELAEEAARLRALAEEAKRQRQ-LAEEDAARQRAE 1857
Query: 534 VMRTYLKQQEKLNLILQKKQQLQMEVKMLSS-SKSMKELTEEQQNLQKELESLQNEHAQR 592
R ++ + + K + ++ +K + ++ ++ L E++ ++ LE +H
Sbjct: 1858 AERVLAEKLAAIGEATRLKTEAEIALKEKEAENERLRRLAEDEAFQRRRLEEQAAQH--- 1914
Query: 593 MEEFYVEQKDLEKKLEQIMKQKCTCDSNLEKDK---------EAEYAGQLAELRQRLDHA 643
+ D+E++L Q+ K DS LE+ K + ++ L+ + A
Sbjct: 1915 -------KADIEERLAQLRK---ASDSELERQKGLVEDTLRQRRQVEEEILALKASFEKA 1964
Query: 644 EADRQELQDELRQEREARQKLEMMIKELKLQILKSSKTAKE 684
A + EL+ EL + R + ++ +L+ + + A E
Sbjct: 1965 AAGKAELELELGRIRSNAEDTLRSKEQAELEAARQRQLAAE 2005
Score = 35.0 bits (79), Expect = 0.23
Identities = 81/419 (19%), Positives = 162/419 (38%), Gaps = 86/419 (20%)
Query: 333 QKYLGTPEE--KKLKIILEEMKE-KFSMRSGKRNQSKTDAPSGMELQSWYPVIKQEGDHV 389
QK L EE ++ K LEE++ K + +R + + + S +LQ ++
Sbjct: 2018 QKSLAAEEEAARQRKAALEEVERLKAKVEEARRLRERAEQESARQLQLAQEAAQKRLQAE 2077
Query: 390 SQTHSFLHPSYYLYMCDKVVAPNVSLTSAVSQSKELT-----KTEASKSISRQSEKAHSS 444
+ H+F V L + Q + + + EA++ + ++E+A
Sbjct: 2078 EKAHAFA-----------VQQKEQELQQTLQQEQSVLDQLRGEAEAARRAAEEAEEARVQ 2126
Query: 445 GKLQKTVSYPDVSLEEQEKMDLKTSRELCSRLDASISNNSTSKRKSESATCNLVRDINKV 504
+ + S V EE E++ + +R A + K + A + +
Sbjct: 2127 AEREAAQSRRQV--EEAERLKQSAEEQAQARAQAQAAAEKLRKEAEQEAARRAQAE--QA 2182
Query: 505 GIGLVAAASSPLLVKDVICED---DKGKIMEEVMRTYLKQQE---KLNLILQKKQQL--- 555
+ AA + + E K ++ +E+ L+ +E + NL+ ++ Q+L
Sbjct: 2183 ALRQKQAADAEMEKHKKFAEQTLRQKAQVEQELTTLRLQLEETDHQKNLLDEELQRLKAE 2242
Query: 556 ---------QMEVKMLSSSKSMKELTE-------------------EQQNLQKELESLQN 587
Q+E ++ S M+EL++ Q+ LQ+E E ++
Sbjct: 2243 ATEAARQRSQVEEELFSVRVQMEELSKLKARIEAENRALILRDKDNTQRFLQEEAEKMKQ 2302
Query: 588 --EHAQRMEEFYVEQKDLEKKLEQIMKQKCTCDSNLEKDK------------EAEYAGQL 633
E A R+ E L + E+ + Q+ + K+K EAE Q
Sbjct: 2303 VAEEAARLSVAAQEAARLRQLAEEDLAQQRALAEKMLKEKMQAVQEATRLKAEAELLQQQ 2362
Query: 634 AELRQ-RLDHAEADRQELQDELRQ---------EREARQKLEMM--IKELKLQILKSSK 680
EL Q + + D++++ +L + E E +++LEM + LKL++ + S+
Sbjct: 2363 KELAQEQARRLQEDKEQMAQQLAEETQGFQRTLEAERQRQLEMSAEAERLKLRVAEMSR 2421
Score = 32.0 bits (71), Expect = 1.9
Identities = 34/158 (21%), Positives = 73/158 (46%), Gaps = 24/158 (15%)
Query: 532 EEVMRTY---LKQQEKLNLILQKKQQLQMEVKMLSSSKSMKE-----LTEEQQNLQKELE 583
EEV+R + LK+ + + L + + + +K L + ++ L +E + Q+ E
Sbjct: 1129 EEVLRAHEEQLKEAQAVPATLPELEATKASLKKLRAQAEAQQPTFDALRDELRGAQEVGE 1188
Query: 584 SLQNEHAQR---MEEFYVEQKDLEKKLEQIMKQKCTCDSNLEK-DKEAEYAGQ------- 632
LQ H +R +E + L ++ + ++ Q LE+ ++ Y +
Sbjct: 1189 RLQQRHGERDVEVERWRERVAQLLERWQAVLAQTDVRQRELEQLGRQLRYYRESADPLGA 1248
Query: 633 -LAELRQRLDHAEA----DRQELQDELRQEREARQKLE 665
L + R+R + +A D Q ++++LRQE+ +++E
Sbjct: 1249 WLQDARRRQEQIQAMPLADSQAVREQLRQEQALLEEIE 1286
>gi|21735548 centrosomal protein 2 [Homo sapiens]
Length = 2442
Score = 56.2 bits (134), Expect = 1e-07
Identities = 55/266 (20%), Positives = 121/266 (45%), Gaps = 33/266 (12%)
Query: 413 VSLTSAVSQS-KELTKTEASKSISRQSEKAHSSGKLQKTVSYPDVSLEEQEKMDLKTSRE 471
VSL + Q+ KEL RQ K K Q+T L+E ++ + +R+
Sbjct: 928 VSLLETLLQTQKELADASQQLERLRQDMKVQKL-KEQETTGILQTQLQEAQRELKEAARQ 986
Query: 472 LCSRLDASISNNSTSKRKSESATCNLVRDINKVGIGLVAAASSPLLVKDVICEDDKGKIM 531
L A++ S+S + + V D+ ++ +DD +++
Sbjct: 987 HRDDL-AALQEESSSLLQDKMDLQKQVEDLKS----------------QLVAQDDSQRLV 1029
Query: 532 EEVMRTYLKQQEKLNLILQK--KQQLQMEVKMLSSSKSMKELTEEQQNLQKELESLQNEH 589
E+ ++ L++ ++ N I ++ +++ + + ++ + + L E Q+EL +L+
Sbjct: 1030 EQEVQEKLRETQEYNRIQKELEREKASLTLSLMEKEQRLLVLQEADSIRQQELSALR--- 1086
Query: 590 AQRMEEFYVEQKDLEKKLEQIMKQKCTCDSNLEKDKEAEYAGQLAELRQRLDHAEADRQE 649
Q M+E EQK+L ++E + ++ K+KEA++ Q A+L + L+ + Q+
Sbjct: 1087 -QDMQEAQGEQKELSAQMELLRQEV--------KEKEADFLAQEAQLLEELEASHITEQQ 1137
Query: 650 LQDELRQEREARQKLEMMIKELKLQI 675
L+ L + +L++ ++ + Q+
Sbjct: 1138 LRASLWAQEAKAAQLQLRLRSTESQL 1163
Score = 50.1 bits (118), Expect = 7e-06
Identities = 58/282 (20%), Positives = 127/282 (45%), Gaps = 34/282 (12%)
Query: 424 ELTKTEASKSISRQSEKAHSSGKLQKTVSYPDVSLEEQEKMDLKTS-RELCSRLDASISN 482
E K K +++ EK + + E+EKM+L+ +E + ++A +
Sbjct: 845 EQQKAAHEKEVNQLREKWEKERSWHQQELAKALESLEREKMELEMRLKEQQTEMEAIQAQ 904
Query: 483 NSTSKRKSESATCNLVRDINKVGIGLVAAASSPLLVKDVICEDDKGKIMEEVMRTY-LKQ 541
+ ++ESA C + + K + L+ K++ + + + + M+ LK+
Sbjct: 905 REEERTQAESALCQMQLETEKERVSLLETLLQTQ--KELADASQQLERLRQDMKVQKLKE 962
Query: 542 QEKLNLILQKKQQLQMEVK---------MLSSSKSMKELTEEQQNLQKELESLQNE---- 588
QE ++ + Q+ Q E+K + + + L +++ +LQK++E L+++
Sbjct: 963 QETTGILQTQLQEAQRELKEAARQHRDDLAALQEESSSLLQDKMDLQKQVEDLKSQLVAQ 1022
Query: 589 -HAQRMEEFYVE------------QKDLEKKLEQIMKQKCTCDSNLEKDKEAEYAGQ--L 633
+QR+ E V+ QK+LE++ + + L +EA+ Q L
Sbjct: 1023 DDSQRLVEQEVQEKLRETQEYNRIQKELEREKASLTLSLMEKEQRLLVLQEADSIRQQEL 1082
Query: 634 AELRQRLDHAEADRQEL--QDELRQEREARQKLEMMIKELKL 673
+ LRQ + A+ +++EL Q EL ++ ++ + + +E +L
Sbjct: 1083 SALRQDMQEAQGEQKELSAQMELLRQEVKEKEADFLAQEAQL 1124
Score = 42.7 bits (99), Expect = 0.001
Identities = 35/144 (24%), Positives = 71/144 (49%), Gaps = 12/144 (8%)
Query: 541 QQEKLNLILQKKQQLQMEVKMLSSSKSMKELTEEQQNLQKELESLQNEHAQRMEEFYVEQ 600
++EK+ L ++ K+Q Q E++ + + + + E Q +LE+ + E +E Q
Sbjct: 881 EREKMELEMRLKEQ-QTEMEAIQAQREEERTQAESALCQMQLET-EKERVSLLETLLQTQ 938
Query: 601 KDLEKKLEQIMKQKCTCDSNLEKDKEAEYAG----QLAELRQRLDHAEADRQE----LQD 652
K+L +Q+ ++ D ++K KE E G QL E ++ L A ++ LQ+
Sbjct: 939 KELADASQQL--ERLRQDMKVQKLKEQETTGILQTQLQEAQRELKEAARQHRDDLAALQE 996
Query: 653 ELRQEREARQKLEMMIKELKLQIL 676
E + + L+ +++LK Q++
Sbjct: 997 ESSSLLQDKMDLQKQVEDLKSQLV 1020
Score = 41.2 bits (95), Expect = 0.003
Identities = 42/145 (28%), Positives = 68/145 (46%), Gaps = 20/145 (13%)
Query: 541 QQEKLNLILQKKQQLQMEVKMLSSSKSMKELTEEQQNLQKELESLQNEHAQRMEEFYVEQ 600
+QE + Q+K + EV L K KE + QQ L K LESL+ E +
Sbjct: 837 EQEGKTALEQQKAAHEKEVNQLRE-KWEKERSWHQQELAKALESLERE-----------K 884
Query: 601 KDLEKKLEQIMKQKCTCDSNLEKDKEAEYAGQLAELRQRLDHAEADRQELQDELRQER-- 658
+LE +L K++ T ++ +E E + L Q E +R L + L Q +
Sbjct: 885 MELEMRL----KEQQTEMEAIQAQREEERTQAESALCQMQLETEKERVSLLETLLQTQKE 940
Query: 659 --EARQKLEMMIKELKLQILKSSKT 681
+A Q+LE + +++K+Q LK +T
Sbjct: 941 LADASQQLERLRQDMKVQKLKEQET 965
Score = 40.0 bits (92), Expect = 0.007
Identities = 60/268 (22%), Positives = 113/268 (42%), Gaps = 49/268 (18%)
Query: 423 KELTKTEASKS-------------ISRQSEKAHSSGKLQKTVSYPDVSLEEQEKMDL-KT 468
+ LT TEA KS Q EK+ GK E E M+L +T
Sbjct: 1271 ERLTDTEAEKSQVHTELQDLQRQLSQNQEEKSKWEGKQNSL---------ESELMELHET 1321
Query: 469 SRELCSRLDASISNNSTSKRKSE---SATCNLVRDINKVGIGLVAA----ASSPLLVKDV 521
L SRL + ++ + E +A NL + + +V A +++ +L +D+
Sbjct: 1322 MASLQSRLRRAELQRMEAQGERELLQAAKENLTAQVEHLQAAVVEARAQASAAGILEEDL 1381
Query: 522 ICEDDKGKIMEEVMRTYLKQ----QEKLNLILQKKQQLQMEVKMLSSSKSMKELTEEQQN 577
K+ E + + ++ QE+ L + + + LQ + +L+ + + +E EE +
Sbjct: 1382 RTARSALKLKNEEVESERERAQALQEQGELKVAQGKALQENLALLTQTLAERE--EEVET 1439
Query: 578 LQKELESLQNEHAQRMEEFYVEQKDLEKKLEQIMKQKCTCDSNLEKDKEAEYAGQLAELR 637
L+ +++ L+ + + + DL+K+ N E D + E +L + R
Sbjct: 1440 LRGQIQELEKQREMQKAALELLSLDLKKR-------------NQEVDLQQEQIQELEKCR 1486
Query: 638 QRLDHAEADRQELQDELRQEREARQKLE 665
L+H QE + +L +RE ++LE
Sbjct: 1487 SVLEHLPMAVQEREQKLTVQREQIRELE 1514
Score = 37.7 bits (86), Expect = 0.035
Identities = 28/114 (24%), Positives = 58/114 (50%), Gaps = 13/114 (11%)
Query: 565 SKSMKELTEEQQNLQKELESLQNEHAQRMEEFYVEQKDLEKKLEQIMKQKCTCDSNLEKD 624
++ + +L EE Q++ +E+ + Q V+ + EK+ E + ++ ++ L+K
Sbjct: 616 NQQLLQLEEENQSVCSRMEAAE----QARNALQVDLAEAEKRREALWEKNTHLEAQLQKA 671
Query: 625 KEAEYAGQLAELRQRLDHAEADRQELQDEL----RQEREARQKLEMMIKELKLQ 674
+EA AEL+ L + +++E+Q +L Q+ A +LE + +E K Q
Sbjct: 672 EEAG-----AELQADLRDIQEEKEEIQKKLSESRHQQEAATTQLEQLHQEAKRQ 720
Score = 37.0 bits (84), Expect = 0.061
Identities = 39/183 (21%), Positives = 84/183 (45%), Gaps = 34/183 (18%)
Query: 526 DKGKIMEEVMRTYLKQQEKLNLI---------------LQKKQQLQMEVKMLSSSKSMKE 570
++ ++ E +M KQ E L+ + L +++Q ++ + + +S+ E
Sbjct: 520 ERERLQEMLMGLEAKQSESLSELITLREALESSHLEGELLRQEQTEVTAALARAEQSIAE 579
Query: 571 LTEEQQNLQKELESLQNEHAQRM---EEFYVEQKDLEKKLEQIMKQKCTCDSNLEKDKEA 627
L+ + L+ E+ L+ + E +++ L ++L Q+ ++ + S +E ++A
Sbjct: 580 LSSSENTLKTEVADLRAAAVKLSALNEALALDKVGLNQQLLQLEEENQSVCSRMEAAEQA 639
Query: 628 EYAGQ--LAELRQRLD-------HAEADRQ-------ELQDELRQEREARQKLEMMIKEL 671
A Q LAE +R + H EA Q ELQ +LR +E +++++ + E
Sbjct: 640 RNALQVDLAEAEKRREALWEKNTHLEAQLQKAEEAGAELQADLRDIQEEKEEIQKKLSES 699
Query: 672 KLQ 674
+ Q
Sbjct: 700 RHQ 702
Score = 36.2 bits (82), Expect = 0.10
Identities = 41/140 (29%), Positives = 63/140 (45%), Gaps = 8/140 (5%)
Query: 539 LKQQEKLNLILQKKQQLQMEVKMLSSSKSMKELTEEQQNL---QKELESLQNE--HAQRM 593
L Q+E+ ++LQ++ Q E L +L E Q+ L +ELE+LQ E AQ
Sbjct: 1773 LSQREQEIVVLQQQLQEAREQGELKEQSLQSQLDEAQRALAQRDQELEALQQEQQQAQGQ 1832
Query: 594 EEFYVEQKD-LEKKLEQIMKQKCTCDSNLEKDKE--AEYAGQLAELRQRLDHAEADRQEL 650
EE E+ D L+ LEQ L+ KE +LA +R+ E +L
Sbjct: 1833 EERVKEKADALQGALEQAHMTLKERHGELQDHKEQARRLEEELAVEGRRVQALEEVLGDL 1892
Query: 651 QDELRQEREARQKLEMMIKE 670
+ E R++ +A L+ E
Sbjct: 1893 RAESREQEKALLALQQQCAE 1912
Score = 34.3 bits (77), Expect = 0.39
Identities = 26/121 (21%), Positives = 60/121 (49%), Gaps = 19/121 (15%)
Query: 566 KSMKELTEEQQNLQKELESLQNEHAQRMEEFYVEQKDLEKKLEQIMKQKCTCDSNLEKDK 625
+++++L ++ Q+ + LQ +H Q E E K L ++L+++ ++ T
Sbjct: 400 QAVQDLRQQLAGCQEAVNLLQQQHDQWEE----EGKALRQRLQKLTGERDT--------- 446
Query: 626 EAEYAGQLAELRQRLDHAEADRQELQ---DELRQEREARQKLEMMIKELKLQILKSSKTA 682
AGQ +L+ +D +R+ LQ +ELRQ+ E ++ ++ + +++ +A
Sbjct: 447 ---LAGQTVDLQGEVDSLSKERELLQKAREELRQQLEVLEQEAWRLRRVNVELQLQGDSA 503
Query: 683 K 683
+
Sbjct: 504 Q 504
Score = 34.3 bits (77), Expect = 0.39
Identities = 42/221 (19%), Positives = 93/221 (42%), Gaps = 23/221 (10%)
Query: 455 DVSLEEQEKMDLKTSRELCSRLDASISNNSTSKRKSESATCNLVRDINKVGIGLVAAASS 514
+V L++++ +L+ R + L ++ L +D + ++
Sbjct: 1471 EVDLQQEQIQELEKCRSVLEHLPMAVQEREQKLTVQREQIRELEKD-RETQRNVLEHQLL 1529
Query: 515 PLLVKDVICEDDKGKIMEEVMRTYLKQQEKLNLILQKKQ-QLQMEVKMLSSSKSMKE--- 570
L KD + E +G++ + ++ L E L L L++ +++ + K++ + +E
Sbjct: 1530 ELEKKDQMIESQRGQVQD--LKKQLVTLECLALELEENHHKMECQQKLIKELEGQRETQR 1587
Query: 571 ---------LTEEQQNLQKE------LESLQNEHAQRMEEFYVEQKDLEKKLEQIMKQKC 615
L E Q LQ + LES A+ ++E E K +++E++ +QK
Sbjct: 1588 VALTHLTLDLEERSQELQAQSSQIHDLESHSTVLARELQERDQEVKSQREQIEELQRQKE 1647
Query: 616 TCDSNLEKDKEAEYAGQLAELRQRLDHAEADRQELQDELRQ 656
+LE+ ++ E Q ++ D + L+++L Q
Sbjct: 1648 HLTQDLER-RDQELMLQKERIQVLEDQRTRQTKILEEDLEQ 1687
Score = 32.7 bits (73), Expect = 1.1
Identities = 52/241 (21%), Positives = 106/241 (43%), Gaps = 23/241 (9%)
Query: 426 TKTEASKSISRQSEKAHSSGK-LQKTVSYPDVSLEEQEKMDLKTSRELCSRLDASISNNS 484
++ E ++++ Q E + GK LQ+ ++ +L E+E+ +++T R L+
Sbjct: 1397 SERERAQALQEQGELKVAQGKALQENLALLTQTLAEREE-EVETLRGQIQELE------- 1448
Query: 485 TSKRKSESATCNLVRDINKVGIGLVAAASSPLLVKDVICEDDKGKIMEEVMRTYLKQQEK 544
+R+ + A L+ + L L ++ I E +K + + E + ++++E+
Sbjct: 1449 -KQREMQKAALELL------SLDLKKRNQEVDLQQEQIQELEKCRSVLEHLPMAVQEREQ 1501
Query: 545 LNLILQKKQQLQMEVKMLSSSKSMKELTEEQQNLQKELESLQNEHAQRMEEFYVEQKDLE 604
L +Q++Q ++E + ++ E + + +ES Q Q +++ V + L
Sbjct: 1502 -KLTVQREQIRELEKDRETQRNVLEHQLLELEKKDQMIES-QRGQVQDLKKQLVTLECLA 1559
Query: 605 KKLEQIMKQKCTCDSNLEKDKEAEYAGQLAELRQRLDHAEADRQELQDELRQEREARQKL 664
+LE+ K C L K+ E GQ R L H D +E EL+ + L
Sbjct: 1560 LELEE-NHHKMECQQKLIKELE----GQRETQRVALTHLTLDLEERSQELQAQSSQIHDL 1614
Query: 665 E 665
E
Sbjct: 1615 E 1615
>gi|63252902 tropomyosin 1 alpha chain isoform 2 [Homo sapiens]
Length = 284
Score = 55.1 bits (131), Expect = 2e-07
Identities = 54/228 (23%), Positives = 111/228 (48%), Gaps = 13/228 (5%)
Query: 460 EQEKMDLKTSRELCSRLDASISNNSTSKRKSESATCNLVRDINKVGIGLVAAASSPLLVK 519
EQ + D K + + +L+ I+ R SE ++ +++K L+AA + +
Sbjct: 23 EQAEADKKAAEDRSKQLEEDIAAKEKLLRVSEDERDRVLEELHKAEDSLLAAEEAAAKAE 82
Query: 520 -DVICEDDKGKIMEEVMRTYLKQQEKLNLILQKKQQLQMEVKMLSSSKSMKELTEEQQNL 578
DV + + +++EE + + QE+L LQK ++ + S + MK + +
Sbjct: 83 ADVASLNRRIQLVEEELD---RAQERLATALQKLEEAEKAAD--ESERGMKVI---ESRA 134
Query: 579 QKELESLQNEHAQRMEEFYVEQKDLEKKLEQIMKQKCTCDSNLEKDKE-AEYA-GQLAEL 636
QK+ E ++ + Q E ++ + D ++K E++ ++ +S+LE+ +E AE + G+ AEL
Sbjct: 135 QKDEEKMEIQEIQLKEAKHIAE-DADRKYEEVARKLVIIESDLERAEERAELSEGKCAEL 193
Query: 637 RQRLDHAEADRQELQDELRQEREARQKLEMMIKELKLQILKSSKTAKE 684
+ L + + L+ + + + + E IK L LK ++T E
Sbjct: 194 EEELKTVTNNLKSLEAQAEKYSQKEDRYEEEIKVLS-DKLKEAETRAE 240
>gi|41872583 Rho-associated, coiled-coil containing protein kinase 2
[Homo sapiens]
Length = 1388
Score = 54.7 bits (130), Expect = 3e-07
Identities = 51/224 (22%), Positives = 107/224 (47%), Gaps = 16/224 (7%)
Query: 467 KTSRELCSRLDASISNNSTSKRKSE-SATCNLVRDINKVGIGLVAAASSPLLVKDVICED 525
K++ E+ + S + ++E AT + D NK+ + A S + ++
Sbjct: 683 KSNMEIDMTYQLKVIQQSLEQEEAEHKATKARLADKNKIYESIEEAKSEAM-------KE 735
Query: 526 DKGKIMEEVMRTYLKQQEKLNLILQKKQQLQMEVKMLSSSKSMKELTEEQQNLQKELESL 585
+ K++EE RT ++ E L L +K+ L ++ + S + + EL +++ L +++ +L
Sbjct: 736 MEKKLLEE--RTLKQKVENLLLEAEKRCSL-LDCDLKQSQQKINELLKQKDVLNEDVRNL 792
Query: 586 QNEHAQRMEEFYVEQKDLEKKLEQIMKQKCT-----CDSNLEKDKEAEYAGQLAELRQRL 640
+ Q ++ + Q DL+ + +Q+ K + ++N + + Q AELR+
Sbjct: 793 TLKIEQETQKRCLTQNDLKMQTQQVNTLKMSEKQLKQENNHLMEMKMNLEKQNAELRKER 852
Query: 641 DHAEADRQELQDELRQEREARQKLEMMIKELKLQILKSSKTAKE 684
A+ +ELQD+L E+ + ++ELK + + +K KE
Sbjct: 853 QDADGQMKELQDQLEAEQYFSTLYKTQVRELKEECEEKTKLGKE 896
Score = 42.7 bits (99), Expect = 0.001
Identities = 63/293 (21%), Positives = 125/293 (42%), Gaps = 45/293 (15%)
Query: 421 QSKELTKTEASKSISRQSEKAHSSGKLQKTVSYPDVSLEEQEKMDLKTSRELCSRLDASI 480
Q K + ++ + ++ KA + K + S + E ++M+ K E L +
Sbjct: 693 QLKVIQQSLEQEEAEHKATKARLADKNKIYESIEEAKSEAMKEMEKKLLEE--RTLKQKV 750
Query: 481 SNNSTSKRKSESAT-CNLVRDINKVGIGLVAAASSPLLVKDVICEDDKG---KIMEEVMR 536
N K S C+L + K+ + L KDV+ ED + KI +E +
Sbjct: 751 ENLLLEAEKRCSLLDCDLKQSQQKI--------NELLKQKDVLNEDVRNLTLKIEQETQK 802
Query: 537 TYLKQQE------KLNLILQKKQQLQ------MEVKMLSSSKSMKELTEEQQNLQKELES 584
L Q + ++N + ++QL+ ME+KM + K EL +E+Q+ +++
Sbjct: 803 RCLTQNDLKMQTQQVNTLKMSEKQLKQENNHLMEMKM-NLEKQNAELRKERQDADGQMKE 861
Query: 585 LQN--EHAQRMEEFYVEQ---------------KDLEKKLEQIMKQKCTCDSNLEKDKEA 627
LQ+ E Q Y Q K+L++K +++ ++ + + LE
Sbjct: 862 LQDQLEAEQYFSTLYKTQVRELKEECEEKTKLGKELQQKKQELQDERDSLAAQLEITLTK 921
Query: 628 EYAGQLAELRQRLDHAEADRQELQDELR-QEREARQKLEMMIKELKLQILKSS 679
+ QLA +++ +++++ EL +E AR K E+ K+ + L+ +
Sbjct: 922 ADSEQLARSIAEEQYSDLEKEKIMKELEIKEMMARHKQELTEKDATIASLEET 974
Score = 35.0 bits (79), Expect = 0.23
Identities = 42/180 (23%), Positives = 81/180 (45%), Gaps = 41/180 (22%)
Query: 527 KGKIMEEVMRTYLKQQEKLNLILQKKQQLQMEVKMLSS--SKSMKELTEE---------- 574
K + +E+ + +E L+ +Q K++L+ + K +++ K+ KEL EE
Sbjct: 438 KNEESQEIQKKLYTLEEHLSNEMQAKEELEQKCKSVNTRLEKTAKELEEEITLRKSVESA 497
Query: 575 QQNLQKELESLQNEHA--QRMEEFYVEQK---------------DLEK----------KL 607
+ L++E LQ+++A QR + ++K DL+K K+
Sbjct: 498 LRQLEREKALLQHKNAEYQRKADHEADKKRNLENDVNSLKDQLEDLKKRNQNSQISTEKV 557
Query: 608 EQIMKQKCTCDSNL--EKDKEAEYAGQLAELRQRLDHAEADRQELQDELRQEREARQKLE 665
Q+ +Q ++ L E D A AE +++ E++ ++LQD+ A+ KLE
Sbjct: 558 NQLQRQLDETNALLRTESDTAARLRKTQAESSKQIQQLESNNRDLQDKNCLLETAKLKLE 617
Score = 31.2 bits (69), Expect = 3.3
Identities = 41/188 (21%), Positives = 91/188 (48%), Gaps = 33/188 (17%)
Query: 526 DKGKIMEEVMRTYLKQQEKLNL---------ILQKKQQLQMEVKMLSSSKSMKELTEEQQ 576
+K KIM+E+ + + K L + + + L +V L++ K +EL + +
Sbjct: 940 EKEKIMKELEIKEMMARHKQELTEKDATIASLEETNRTLTSDVANLANEK--EELNNKLK 997
Query: 577 NLQKELESLQNEHAQ------RMEEFYVEQKDLE----KKLEQIMKQKCTC----DSNLE 622
++Q++L L++E + E+ + ++ L+ KL +IM +K D+++
Sbjct: 998 DVQEQLSRLKDEEISAAAIKAQFEKQLLTERTLKTQAVNKLAEIMNRKEPVKRGNDTDVR 1057
Query: 623 -KDKE-----AEYAGQLAELRQRLDHAEADRQELQDELRQEREARQKLEMMI--KELKLQ 674
K+KE E + +L Q++ + + E+Q ++ +E + R +L+M + K+ ++
Sbjct: 1058 RKEKENRKLHMELKSEREKLTQQMIKYQKELNEMQAQIAEESQIRIELQMTLDSKDSDIE 1117
Query: 675 ILKSSKTA 682
L+S A
Sbjct: 1118 QLRSQLQA 1125
>gi|148746195 trichohyalin [Homo sapiens]
Length = 1943
Score = 54.3 bits (129), Expect = 4e-07
Identities = 37/160 (23%), Positives = 85/160 (53%), Gaps = 12/160 (7%)
Query: 519 KDVICEDDKGKIMEEVMRTYLKQQEKLNLILQKKQQLQMEVKMLSSSKSMKELTEEQQNL 578
+ ++ E+ + + +E R Y K+ E + Q+++QL E + + + E++ L
Sbjct: 1001 EQLLREEREKRRRQEWERQYRKKDE----LQQEEEQLLREEREKRRLQERERQYREEEEL 1056
Query: 579 QKELESLQNEHA-----QRMEEFYVEQKDLEKKLEQIMKQKCTCDSNLEKDKEAEYAGQL 633
Q+E E L E Q +E Y ++++L+++ EQ+++++ E++++ +L
Sbjct: 1057 QQEEEQLLGEERETRRRQELERQYRKEEELQQEEEQLLREEPEKRRRQERERQCREEEEL 1116
Query: 634 AELRQRLDHAEAD---RQELQDELRQEREARQKLEMMIKE 670
+ ++L E + RQEL+ + R+E E +Q+ E +++E
Sbjct: 1117 QQEEEQLLREEREKRRRQELERQYREEEEVQQEEEQLLRE 1156
Score = 51.2 bits (121), Expect = 3e-06
Identities = 32/127 (25%), Positives = 62/127 (48%), Gaps = 10/127 (7%)
Query: 550 QKKQQLQMEVKMLSSSKSMKELTEEQQNLQKELESLQNEHAQRMEEFYVEQKDL------ 603
+K+QQ + + + KE + + L+KE E LQ E QR E E++ L
Sbjct: 225 EKQQQRRERQDRVFQEEEEKEWRKRETVLRKEEEKLQEEEPQRQRELQEEEEQLRKLERQ 284
Query: 604 ----EKKLEQIMKQKCTCDSNLEKDKEAEYAGQLAELRQRLDHAEADRQELQDELRQERE 659
E++ E+ +Q+ + L + +E E Q E R++ + E + + +LR+E+E
Sbjct: 285 ELRRERQEEEQQQQRLRREQQLRRKQEEERREQQEERREQQERREQQEERREQQLRREQE 344
Query: 660 ARQKLEM 666
R++ ++
Sbjct: 345 ERREQQL 351
Score = 47.8 bits (112), Expect = 3e-05
Identities = 34/160 (21%), Positives = 85/160 (53%), Gaps = 12/160 (7%)
Query: 519 KDVICEDDKGKIMEEVMRTYLKQQEKLNLILQKKQQLQMEVKMLSSSKSMKELTEEQQNL 578
+ ++ E+ + + ++E R Y +++E + Q+++QL E + + ++ +++ L
Sbjct: 1031 EQLLREEREKRRLQERERQYREEEE----LQQEEEQLLGEERETRRRQELERQYRKEEEL 1086
Query: 579 QKELESLQNEHA-----QRMEEFYVEQKDLEKKLEQIMKQKCTCDSNLEKDKEAEYAGQL 633
Q+E E L E Q E E+++L+++ EQ+++++ E +++ ++
Sbjct: 1087 QQEEEQLLREEPEKRRRQERERQCREEEELQQEEEQLLREEREKRRRQELERQYREEEEV 1146
Query: 634 AELRQRLDHAEAD---RQELQDELRQEREARQKLEMMIKE 670
+ ++L E + RQEL+ + R+E E +Q+ E +++E
Sbjct: 1147 QQEEEQLLREEPEKRRRQELERQYREEEELQQEEEQLLRE 1186
Score = 47.4 bits (111), Expect = 4e-05
Identities = 37/160 (23%), Positives = 83/160 (51%), Gaps = 12/160 (7%)
Query: 519 KDVICEDDKGKIMEEVMRTYLKQQEKLNLILQKKQQLQMEVKMLSSSKSMKELTEEQQNL 578
+ ++ E+ + + +E R Y K ++ + QK++QL E + ++ E++ L
Sbjct: 941 EQLLREEREKRRRQERERQYRKDKK----LQQKEEQLLGEEPEKRRRQEREKKYREEEEL 996
Query: 579 QKELESLQNEHA-----QRMEEFYVEQKDLEKKLEQIMKQKCTCDSNLEKDKEAEYAGQL 633
Q+E E L E Q E Y ++ +L+++ EQ+++++ E++++ +L
Sbjct: 997 QQEEEQLLREEREKRRRQEWERQYRKKDELQQEEEQLLREEREKRRLQERERQYREEEEL 1056
Query: 634 AELRQRLDHAEAD---RQELQDELRQEREARQKLEMMIKE 670
+ ++L E + RQEL+ + R+E E +Q+ E +++E
Sbjct: 1057 QQEEEQLLGEERETRRRQELERQYRKEEELQQEEEQLLRE 1096
Score = 46.6 bits (109), Expect = 8e-05
Identities = 39/161 (24%), Positives = 81/161 (50%), Gaps = 17/161 (10%)
Query: 519 KDVICEDDKGKIMEEVMRTYLKQQEKLNLILQKKQQLQMEVKMLSSSKSMKELTEEQQNL 578
+ ++ E+ + + +E+ R Y K++E + Q+++QL E + + E++ L
Sbjct: 1061 EQLLGEERETRRRQELERQYRKEEE----LQQEEEQLLREEPEKRRRQERERQCREEEEL 1116
Query: 579 QKELESLQNEHA-----QRMEEFYVEQKDLEKKLEQIMKQKCTCDSNLEKDKEAEYAGQL 633
Q+E E L E Q +E Y E+++++++ EQ+++++ EK + E Q
Sbjct: 1117 QQEEEQLLREEREKRRRQELERQYREEEEVQQEEEQLLREEP------EKRRRQELERQY 1170
Query: 634 AELRQRLDHAEADRQELQDELRQEREA--RQKLEMMIKELK 672
E + E +E Q++ RQERE R++ E+ ++ K
Sbjct: 1171 REEEELQQEEEQLLREEQEKRRQERERQYREEEELQRQKRK 1211
Score = 45.8 bits (107), Expect = 1e-04
Identities = 40/147 (27%), Positives = 76/147 (51%), Gaps = 16/147 (10%)
Query: 526 DKGKIMEEVMRTYLKQQEKLNLILQKKQQLQMEVKMLSSSKSMKELTEEQQNLQKELESL 585
++ ++++E L++QE+ +++QQL+ + + K L EEQQ ++ELE
Sbjct: 1671 EEEQLLQEGEEQQLRRQERDRKFREEEQQLRRQ------ERERKFLQEEQQLRRQELERK 1724
Query: 586 QNEHAQRMEEFYVEQKDLEKKLEQIMKQKCTCDS-------NLEKDKEAEYAGQLAELR- 637
E Q +E EQ +++ +I++++ E+D++ QL + R
Sbjct: 1725 FREEEQLRQETEQEQLRRQERYRKILEEEQLRPEREEQQLRRQERDRKFREEEQLRQERE 1784
Query: 638 -QRLDHAEADRQELQDE-LRQEREARQ 662
Q+L E+DR+ ++E LRQERE +Q
Sbjct: 1785 EQQLRSQESDRKFREEEQLRQEREEQQ 1811
Score = 44.7 bits (104), Expect = 3e-04
Identities = 42/147 (28%), Positives = 72/147 (48%), Gaps = 12/147 (8%)
Query: 529 KIMEEVMRTYLKQQEKLNLILQKKQQLQMEVK--MLSSSKSMKELTEEQQNLQKELESLQ 586
K +EE R L++QE+ L+++QQL+ + + L + K EEQQ ++E +
Sbjct: 1375 KFLEEEQR--LRRQERERKFLKEEQQLRCQEREQQLRQDRDRKFREEEQQLSRQERDRKF 1432
Query: 587 NEHAQRMEEFYVEQKDL--EKKLEQIMKQKCTCDSNLEKDKE------AEYAGQLAELRQ 638
E Q++ E+K L E++L Q +K + L +++E E + E Q
Sbjct: 1433 REEEQQVRRQERERKFLEEEQQLRQERHRKFREEEQLLQEREEQQLHRQERDRKFLEEEQ 1492
Query: 639 RLDHAEADRQELQDELRQEREARQKLE 665
+L E DR+ + ELR + R+ LE
Sbjct: 1493 QLRRQERDRKFREQELRSQEPERKFLE 1519
Score = 44.3 bits (103), Expect = 4e-04
Identities = 34/138 (24%), Positives = 69/138 (50%), Gaps = 3/138 (2%)
Query: 540 KQQEKLNLILQKKQQLQMEVKMLSSSKSMKE--LTEEQQNLQKELESLQNEHAQRMEEFY 597
+QQ + L+++QQL+ E ++ + +E L EQ+ + E + Q QR++
Sbjct: 392 EQQLRREQQLRREQQLRREQQLRREQQLRREQQLRREQEEERHEQKHEQERREQRLKREQ 451
Query: 598 VEQKDLEKKLEQIMK-QKCTCDSNLEKDKEAEYAGQLAELRQRLDHAEADRQELQDELRQ 656
E++D K+ E+ + ++ L++D+E E + +L + + +R+E Q Q
Sbjct: 452 EERRDWLKREEETERHEQERRKQQLKRDQEEERRERWLKLEEEERREQQERREQQLRREQ 511
Query: 657 EREARQKLEMMIKELKLQ 674
E Q+L+ +E +LQ
Sbjct: 512 EERREQRLKRQEEEERLQ 529
Score = 43.5 bits (101), Expect = 6e-04
Identities = 30/134 (22%), Positives = 74/134 (55%), Gaps = 8/134 (5%)
Query: 540 KQQEKLNLILQKKQQLQMEVKMLSSSKSMKELTEEQQNLQKELESLQNEHAQRMEEFYVE 599
+++E+L ++K++ Q + + + +++ EE+Q L++E E + + +R Y +
Sbjct: 908 EEEEELQREEREKRRRQEQERQYREEEQLQQ--EEEQLLREEREKRRRQERERQ---YRK 962
Query: 600 QKDLEKKLEQIMKQKCTCDSNLEKDKEAEYAGQLAELRQRLDHAEAD---RQELQDELRQ 656
K L++K EQ++ ++ E++K+ +L + ++L E + RQE + + R+
Sbjct: 963 DKKLQQKEEQLLGEEPEKRRRQEREKKYREEEELQQEEEQLLREEREKRRRQEWERQYRK 1022
Query: 657 EREARQKLEMMIKE 670
+ E +Q+ E +++E
Sbjct: 1023 KDELQQEEEQLLRE 1036
Score = 43.1 bits (100), Expect = 8e-04
Identities = 33/146 (22%), Positives = 75/146 (51%), Gaps = 11/146 (7%)
Query: 524 EDDKGKIMEEVMRTYLKQQEKLNLILQKKQQLQMEVKMLSSSKSMKELTEEQQNLQKELE 583
E+++ ++ R +L+++++L + +Q+ Q + + +++ EEQQ L
Sbjct: 1519 EEEQQLHRQQRQRKFLQEEQQLRRQERGQQRRQDRDRKFREEEQLRQEREEQQ-----LS 1573
Query: 584 SLQNEHAQRMEEFYVEQKDLEKKL----EQIMKQKCTCDSNLEKDKEAEYAGQLAELR-- 637
+ + R+EE V +++ E+K +Q+ +Q+ E+D++ QL + R
Sbjct: 1574 RQERDRKFRLEEQKVRRQEQERKFMEDEQQLRRQEGQQQLRQERDRKFREDEQLLQEREE 1633
Query: 638 QRLDHAEADRQELQDELRQEREARQK 663
Q+L E DR+ L++E + R+ R++
Sbjct: 1634 QQLHRQERDRKFLEEEPQLRRQEREQ 1659
Score = 42.7 bits (99), Expect = 0.001
Identities = 34/130 (26%), Positives = 65/130 (50%), Gaps = 13/130 (10%)
Query: 554 QLQMEVKMLSSSKSMKELTEEQQN-----LQKELESLQNE-----HAQRMEEFYVEQKDL 603
QL+ E K + K +EQ LQ+E E LQ E Q E Y E++ L
Sbjct: 877 QLEEERKRRRHTLYAKPALQEQLRKEQQLLQEEEEELQREEREKRRRQEQERQYREEEQL 936
Query: 604 EKKLEQIMKQKCTCDSNLEKDKEAEYAGQLAELRQRLDHAEAD---RQELQDELRQEREA 660
+++ EQ+++++ E++++ +L + ++L E + RQE + + R+E E
Sbjct: 937 QQEEEQLLREEREKRRRQERERQYRKDKKLQQKEEQLLGEEPEKRRRQEREKKYREEEEL 996
Query: 661 RQKLEMMIKE 670
+Q+ E +++E
Sbjct: 997 QQEEEQLLRE 1006
Score = 42.0 bits (97), Expect = 0.002
Identities = 36/141 (25%), Positives = 76/141 (53%), Gaps = 10/141 (7%)
Query: 540 KQQEKLNLILQKKQQLQMEV----KMLSSSKSMKELTEE--QQNLQKELESLQNEHAQRM 593
+++E+L L+ +QQL+ E + L + K L +E +Q L++E E +++ +R
Sbjct: 523 EEEERLQQRLRSEQQLRREQEERREQLLKREEEKRLEQERREQRLKREQEERRDQLLKRE 582
Query: 594 EEFYVE--QKDLEKKLEQIMKQKCTCDSNLEKDKEAEYAGQ--LAELRQRLDHAEADRQE 649
EE + +++ E++LEQ +K++ E+ +E + E RQ+L +E +
Sbjct: 583 EERRQQRLKREQEERLEQRLKREEVERLEQEERREQRLKREEPEEERRQQLLKSEEQEER 642
Query: 650 LQDELRQEREARQKLEMMIKE 670
Q +LR+E++ R++ + +E
Sbjct: 643 RQQQLRREQQERREQRLKREE 663
Score = 41.6 bits (96), Expect = 0.002
Identities = 25/151 (16%), Positives = 80/151 (52%), Gaps = 8/151 (5%)
Query: 524 EDDKGKIMEEVMRTYLKQQEKLNLILQKKQQLQMEVKMLSSSKSMKELTEEQQNLQKELE 583
E+ + + E V+R K++EKL ++++ Q + ++ + +++L ++ +++ E
Sbjct: 242 EEKEWRKRETVLR---KEEEKL-----QEEEPQRQRELQEEEEQLRKLERQELRRERQEE 293
Query: 584 SLQNEHAQRMEEFYVEQKDLEKKLEQIMKQKCTCDSNLEKDKEAEYAGQLAELRQRLDHA 643
Q + +R ++ +Q++ ++ ++ +++ E+ +E + + E R++
Sbjct: 294 EQQQQRLRREQQLRRKQEEERREQQEERREQQERREQQEERREQQLRREQEERREQQLRR 353
Query: 644 EADRQELQDELRQEREARQKLEMMIKELKLQ 674
E + + + +LR+E+E ++ + + +E +L+
Sbjct: 354 EQEEERREQQLRREQEEERREQQLRREQQLR 384
Score = 41.6 bits (96), Expect = 0.002
Identities = 36/167 (21%), Positives = 87/167 (52%), Gaps = 14/167 (8%)
Query: 519 KDVICEDDKGKIMEEVMRTYLKQQEKLNLILQKKQQLQMEVKMLSSSKSMKELTEEQQNL 578
+ ++ E+ + + +E + Y +++E + Q+++QL E + + + ++ L
Sbjct: 971 EQLLGEEPEKRRRQEREKKYREEEE----LQQEEEQLLREEREKRRRQEWERQYRKKDEL 1026
Query: 579 QKELESLQNEHA-----QRMEEFYVEQKDLEKKLEQIMKQKCTCDSNLEKDKEAEYAGQL 633
Q+E E L E Q E Y E+++L+++ EQ++ ++ ++ ++ E +Y +
Sbjct: 1027 QQEEEQLLREEREKRRLQERERQYREEEELQQEEEQLLGEER--ETRRRQELERQYRKE- 1083
Query: 634 AELRQRLDHAEADRQELQDELRQEREARQKLEMMIKELKLQILKSSK 680
EL+Q + + R+E + RQERE + + E +++ + Q+L+ +
Sbjct: 1084 EELQQ--EEEQLLREEPEKRRRQERERQCREEEELQQEEEQLLREER 1128
Score = 40.8 bits (94), Expect = 0.004
Identities = 32/143 (22%), Positives = 75/143 (52%), Gaps = 10/143 (6%)
Query: 524 EDDKGKIMEEVMRTYLKQQEKLNLILQKKQQLQMEVKMLSSSKSMKELTEEQQNLQKELE 583
E+ K+ + +R +++E+ L+++QQL+ K + +E EQQ +++ E
Sbjct: 275 EEQLRKLERQELRRERQEEEQQQQRLRREQQLRR--KQEEERREQQEERREQQERREQQE 332
Query: 584 SLQNEHAQRMEEFYVEQKDLEKKLEQIMKQKCTCDSNLEKDKEAEYAGQLAELRQRLDHA 643
+ + +R +E E+++ + + EQ +++ + L +++E E Q Q+L
Sbjct: 333 ERREQQLRREQE---ERREQQLRREQEEERR---EQQLRREQEEERREQQLRREQQLRRE 386
Query: 644 EADRQELQDELRQEREARQKLEM 666
+ R+E Q LR+E++ R++ ++
Sbjct: 387 QQLRREQQ--LRREQQLRREQQL 407
Score = 40.8 bits (94), Expect = 0.004
Identities = 31/149 (20%), Positives = 73/149 (48%), Gaps = 17/149 (11%)
Query: 532 EEVMRTYLKQQEKLNLILQKKQQLQMEVKMLSSSKSMKELTEEQQNLQKELESLQNEHAQ 591
+E R +++EK L++++QLQ + ++L EE+ LQ++ E +++ +
Sbjct: 817 KEQRRRQRREREKELQFLEEEEQLQRRERA-------QQLQEEEDGLQEDQERRRSQEQR 869
Query: 592 RMEEFYVEQKDLEKKLEQIMKQKCTCDSNLEKDKEAEYAGQLAELRQRLDHAEADRQELQ 651
R +++ + ++ K+ + K L K+++ L E + E R+E +
Sbjct: 870 RDQKWRWQLEEERKRRRHTLYAKPALQEQLRKEQQL-----LQE-----EEEELQREERE 919
Query: 652 DELRQEREARQKLEMMIKELKLQILKSSK 680
RQE+E + + E +++ + Q+L+ +
Sbjct: 920 KRRRQEQERQYREEEQLQQEEEQLLREER 948
Score = 40.0 bits (92), Expect = 0.007
Identities = 34/134 (25%), Positives = 68/134 (50%), Gaps = 18/134 (13%)
Query: 532 EEVMRTYLKQQEKLNLILQKKQQLQMEVKMLSSSKSMKELTEEQQNLQKELESLQNEHAQ 591
E +R +QQ + + +++++ Q + K ++ L EE+Q LQ+ E AQ
Sbjct: 795 ERQLRAEERQQREQRFLPEEEEKEQRRRQRREREKELQFLEEEEQ-LQR------RERAQ 847
Query: 592 RMEEFYVEQKDLEKKLEQIMKQKCTCDSNLEKDKEAEYAGQLAELRQRLDHAEADRQELQ 651
+++E E+ L++ E+ Q E+ ++ ++ QL E R+R H + LQ
Sbjct: 848 QLQE---EEDGLQEDQERRRSQ--------EQRRDQKWRWQLEEERKRRRHTLYAKPALQ 896
Query: 652 DELRQEREARQKLE 665
++LR+E++ Q+ E
Sbjct: 897 EQLRKEQQLLQEEE 910
Score = 40.0 bits (92), Expect = 0.007
Identities = 30/134 (22%), Positives = 71/134 (52%), Gaps = 13/134 (9%)
Query: 541 QQEKLNLILQKKQQLQMEVKMLSSSKSMKELTEEQQNLQKELESLQNEHAQRMEEFYVEQ 600
QQE+ L+ +++++ + + + K K +E+Q L +E E + Q E+ Y E+
Sbjct: 937 QQEEEQLLREEREKRRRQERERQYRKDKKLQQKEEQLLGEEPEKRRR---QEREKKYREE 993
Query: 601 KDLEKKLEQIMKQKCTCDSNLEKDKEAEYAGQLAELRQRLDHAEADRQELQDELRQEREA 660
++L+++ EQ+++++ EK + E+ Q ++ D + + ++L E R++R
Sbjct: 994 EELQQEEEQLLREE------REKRRRQEWERQY----RKKDELQQEEEQLLREEREKRRL 1043
Query: 661 RQKLEMMIKELKLQ 674
+++ +E +LQ
Sbjct: 1044 QERERQYREEEELQ 1057
Score = 39.3 bits (90), Expect = 0.012
Identities = 29/150 (19%), Positives = 78/150 (52%), Gaps = 5/150 (3%)
Query: 519 KDVICEDDKGKIMEEVMRTYLKQQEKLNLILQKKQQLQMEVKMLSSSKSMKELTEEQQNL 578
++ + ++ K+ EE + + QE+ L+K ++ ++ + + + L EQQ
Sbjct: 249 RETVLRKEEEKLQEEEPQRQRELQEEEEQ-LRKLERQELRRERQEEEQQQQRLRREQQLR 307
Query: 579 QKELESLQNEHAQRMEEFYVEQKDLEKKLEQIMK-QKCTCDSNLEKDKEAEYAGQLAELR 637
+K+ E + + +R E+ ++ E++ +Q+ + Q+ + L +++E E Q +LR
Sbjct: 308 RKQEEERREQQEERREQQERREQQEERREQQLRREQEERREQQLRREQEEERREQ--QLR 365
Query: 638 QRLDHAEADRQ-ELQDELRQEREARQKLEM 666
+ + ++Q + +LR+E++ R++ ++
Sbjct: 366 REQEEERREQQLRREQQLRREQQLRREQQL 395
Score = 39.3 bits (90), Expect = 0.012
Identities = 32/128 (25%), Positives = 63/128 (49%), Gaps = 8/128 (6%)
Query: 540 KQQEKLNLILQKKQQLQMEVKMLSSSKSMKELTEE--QQNLQKELESLQNEHAQRMEEFY 597
+QQE+ +++QQL+ E + + +E EE +Q L++E E + E R E+
Sbjct: 329 EQQEE-----RREQQLRREQEERREQQLRREQEEERREQQLRREQEEERREQQLRREQQL 383
Query: 598 VEQKDLEKKLEQIMKQKCTCDSNLEKDKEAEYAGQLAELRQRLDHAEADRQELQDELRQE 657
++ L ++ + +Q+ + L ++++ QL +Q E +R E + E ++
Sbjct: 384 RREQQLRREQQLRREQQLRREQQLRREQQLRREQQLRREQQLRREQEEERHEQKHE-QER 442
Query: 658 REARQKLE 665
RE R K E
Sbjct: 443 REQRLKRE 450
Score = 38.9 bits (89), Expect = 0.016
Identities = 35/144 (24%), Positives = 71/144 (49%), Gaps = 7/144 (4%)
Query: 538 YLKQQEKLNLILQKKQQLQMEVKMLSSSKSMKELTEEQQNLQKELESLQNEHAQRMEEFY 597
+L+++E+L ++ QQLQ E L + + ++EQ+ QK L+ E +R Y
Sbjct: 833 FLEEEEQLQR-RERAQQLQEEEDGLQEDQERRR-SQEQRRDQKWRWQLEEERKRRRHTLY 890
Query: 598 VE---QKDLEKKLEQIMKQKCTCD-SNLEKDKEAEYAGQLAELRQ-RLDHAEADRQELQD 652
+ Q+ L K+ + + +++ EK + E Q E Q + + + R+E +
Sbjct: 891 AKPALQEQLRKEQQLLQEEEEELQREEREKRRRQEQERQYREEEQLQQEEEQLLREEREK 950
Query: 653 ELRQEREARQKLEMMIKELKLQIL 676
RQERE + + + +++ + Q+L
Sbjct: 951 RRRQERERQYRKDKKLQQKEEQLL 974
Score = 38.9 bits (89), Expect = 0.016
Identities = 28/160 (17%), Positives = 80/160 (50%), Gaps = 2/160 (1%)
Query: 524 EDDKGKIMEEVMRTYLKQQEKLNLILQKKQQLQMEVKMLSSSKSMKELTEEQQNLQKELE 583
+D K EE +++++L+ ++ ++ ++E + + + ++ E++Q L+++ E
Sbjct: 1551 QDRDRKFREEEQLRQEREEQQLSR-QERDRKFRLEEQKVRRQEQERKFMEDEQQLRRQ-E 1608
Query: 584 SLQNEHAQRMEEFYVEQKDLEKKLEQIMKQKCTCDSNLEKDKEAEYAGQLAELRQRLDHA 643
Q +R +F +++ L+++ EQ + ++ LE++ + + +LR D
Sbjct: 1609 GQQQLRQERDRKFREDEQLLQEREEQQLHRQERDRKFLEEEPQLRRQEREQQLRHDRDRK 1668
Query: 644 EADRQELQDELRQEREARQKLEMMIKELKLQILKSSKTAK 683
+ ++L E +++ RQ+ + +E + Q+ + + K
Sbjct: 1669 FREEEQLLQEGEEQQLRRQERDRKFREEEQQLRRQERERK 1708
Score = 38.5 bits (88), Expect = 0.021
Identities = 34/140 (24%), Positives = 69/140 (49%), Gaps = 29/140 (20%)
Query: 540 KQQEKLNLILQKKQQLQMEVKMLSSSKSMKELTEEQQNLQKELESLQNE-----HAQRME 594
+++E+L Q+++QL E + + ++ E++ +Q+E E L E Q +E
Sbjct: 1111 REEEELQ---QEEEQLLREEREKRRRQELERQYREEEEVQQEEEQLLREEPEKRRRQELE 1167
Query: 595 EFYVEQKDLEKKLEQIMKQKCTCDSNLEKDKEAEYAGQLAELRQRLDHAEADRQELQDEL 654
Y E+++L+++ EQ++++ E++K RQ + + +ELQ
Sbjct: 1168 RQYREEEELQQEEEQLLRE--------EQEKR----------RQERERQYREEEELQ--- 1206
Query: 655 RQEREARQKLEMMIKELKLQ 674
RQ+R+ R + E +LK Q
Sbjct: 1207 RQKRKQRYRDEDQRSDLKWQ 1226
Score = 38.1 bits (87), Expect = 0.027
Identities = 36/154 (23%), Positives = 70/154 (45%), Gaps = 16/154 (10%)
Query: 540 KQQEKLNLILQKKQQLQMEVKMLSSSKSMKELTEEQQNLQKELESLQNEHAQRMEE---F 596
+QQ + L+++QQL+ E ++ + +E EE+ + E E + + EE +
Sbjct: 398 EQQLRREQQLRREQQLRREQQLRREQQLRREQEEERHEQKHEQERREQRLKREQEERRDW 457
Query: 597 YVEQKDLEKKLEQIMKQKCTCDSNLE------KDKEAEYAGQLAELRQRLDHAEADR--- 647
+++ E+ ++ KQ+ D E K +E E Q Q+L + +R
Sbjct: 458 LKREEETERHEQERRKQQLKRDQEEERRERWLKLEEEERREQQERREQQLRREQEERREQ 517
Query: 648 ----QELQDELRQEREARQKLEMMIKELKLQILK 677
QE ++ L+Q + Q+L +E + Q+LK
Sbjct: 518 RLKRQEEEERLQQRLRSEQQLRREQEERREQLLK 551
Score = 38.1 bits (87), Expect = 0.027
Identities = 34/129 (26%), Positives = 66/129 (51%), Gaps = 3/129 (2%)
Query: 539 LKQQEKLNLILQKKQQLQ-MEVKMLSSSKSMKELTEEQQNLQKELESLQNEHAQRMEEFY 597
L++QE+ +++Q Q E + L S +S ++ EE+Q L++E E Q QR ++
Sbjct: 1764 LRRQERDRKFREEEQLRQEREEQQLRSQESDRKFREEEQ-LRQEREEQQLRPQQRDGKYR 1822
Query: 598 VEQKDLE-KKLEQIMKQKCTCDSNLEKDKEAEYAGQLAELRQRLDHAEADRQELQDELRQ 656
E++ L+ ++ EQ ++Q+ E+ + + E + + RQE + +LR+
Sbjct: 1823 WEEEQLQLEEQEQRLRQERDRQYRAEEQFATQEKSRREEQELWQEEEQKRRQERERKLRE 1882
Query: 657 EREARQKLE 665
E RQ+ E
Sbjct: 1883 EHIRRQQKE 1891
Score = 37.7 bits (86), Expect = 0.035
Identities = 31/126 (24%), Positives = 69/126 (54%), Gaps = 17/126 (13%)
Query: 550 QKKQQLQMEVKMLSSSKS--MKELTEEQQNLQKEL--------ESLQNEHAQRMEEFYVE 599
Q++++ + E + L S K +E +E+Q ++EL E Q + +R + + E
Sbjct: 181 QEREERRAEEEQLQSCKGHETEEFPDEEQLRRRELLELRRKGREEKQQQRRERQDRVFQE 240
Query: 600 QKDLE-KKLEQIMKQKCTCDSNLEKDKEAEYAGQLAELRQRLDHAEADRQELQDELRQER 658
+++ E +K E +++++ + L+++ E + +L E ++L E RQEL+ E ++E
Sbjct: 241 EEEKEWRKRETVLRKE---EEKLQEE-EPQRQRELQEEEEQLRKLE--RQELRRERQEEE 294
Query: 659 EARQKL 664
+ +Q+L
Sbjct: 295 QQQQRL 300
Score = 37.7 bits (86), Expect = 0.035
Identities = 39/147 (26%), Positives = 77/147 (52%), Gaps = 9/147 (6%)
Query: 540 KQQEKLNLILQKKQQLQMEVKMLSSSKSMKE--LTEEQQNLQKELESLQNEHAQRMEEFY 597
+QQ + L+++QQL+ E ++ + +E L EQQ +++ + + + EE
Sbjct: 374 EQQLRREQQLRREQQLRREQQLRREQQLRREQQLRREQQLRREQQLRREQQLRREQEEER 433
Query: 598 VEQKDLEKKLEQIMKQKCTCDSN-LEKDKEAEYAGQLAELRQRLDHAEADRQE----LQD 652
EQK +++ EQ +K++ + L++++E E Q +Q E +R+E L++
Sbjct: 434 HEQKHEQERREQRLKREQEERRDWLKREEETERHEQERRKQQLKRDQEEERRERWLKLEE 493
Query: 653 ELRQEREAR--QKLEMMIKELKLQILK 677
E R+E++ R Q+L +E + Q LK
Sbjct: 494 EERREQQERREQQLRREQEERREQRLK 520
Score = 37.4 bits (85), Expect = 0.046
Identities = 30/133 (22%), Positives = 66/133 (49%), Gaps = 11/133 (8%)
Query: 550 QKKQQLQMEVKMLSSSKSMKELTEE---------QQNLQKELESLQNEHAQRMEEFYVEQ 600
+++QQL+ E + + ++ EE +Q L++E + L+ E R E+ +
Sbjct: 346 RREQQLRREQEEERREQQLRREQEEERREQQLRREQQLRRE-QQLRREQQLRREQQLRRE 404
Query: 601 KDLEKKLEQIMKQKCTCDSNLEKDKEAEYAGQLAELRQRLDHAEADRQELQDELRQEREA 660
+ L ++ + +Q+ + L +++E E Q E +R + +++E +D L++E E
Sbjct: 405 QQLRREQQLRREQQLRREQQLRREQEEERHEQKHEQERREQRLKREQEERRDWLKREEET 464
Query: 661 -RQKLEMMIKELK 672
R + E ++LK
Sbjct: 465 ERHEQERRKQQLK 477
Score = 37.4 bits (85), Expect = 0.046
Identities = 30/159 (18%), Positives = 78/159 (49%), Gaps = 8/159 (5%)
Query: 523 CEDDKGKIMEEVMRTYLKQQEKLNLILQKKQQLQMEVKMLSSSKSMKELTEEQQ------ 576
C++ + ++ ++ R + +++++L+ + ++ + E ++ + K L EEQQ
Sbjct: 1401 CQEREQQLRQDRDRKFREEEQQLSRQERDRKFREEEQQVRRQERERKFLEEEQQLRQERH 1460
Query: 577 -NLQKELESLQNEHAQRMEEFYVEQKDLEKKLEQIMKQKCTCDSNLEKDKEAEYAGQLAE 635
++E + LQ Q++ ++K LE++ +Q+ +Q+ ++ + E + E
Sbjct: 1461 RKFREEEQLLQEREEQQLHRQERDRKFLEEE-QQLRRQERDRKFREQELRSQEPERKFLE 1519
Query: 636 LRQRLDHAEADRQELQDELRQEREARQKLEMMIKELKLQ 674
Q+L + R+ LQ+E + R+ R + ++ K +
Sbjct: 1520 EEQQLHRQQRQRKFLQEEQQLRRQERGQQRRQDRDRKFR 1558
Score = 36.6 bits (83), Expect = 0.079
Identities = 35/131 (26%), Positives = 67/131 (51%), Gaps = 14/131 (10%)
Query: 550 QKKQQLQMEVKMLSSSKSMKELTEEQQNLQKELESLQNEHAQRMEEFYVEQKDLEKKLEQ 609
QK+Q+ + E+ +E +E+Q+ L++ ++E R + + E++ E++ E+
Sbjct: 139 QKRQEQERELA------EGEEQSEKQERLEQRDRQRRDEELWRQRQEWQERE--ERRAEE 190
Query: 610 IMKQKCTCDSNLE-KDKEAEYAGQLAELRQR-LDHAEADRQELQDELRQEREARQ--KLE 665
Q C E D+E +L ELR++ + + R+E QD + QE E ++ K E
Sbjct: 191 EQLQSCKGHETEEFPDEEQLRRRELLELRRKGREEKQQQRRERQDRVFQEEEEKEWRKRE 250
Query: 666 MMIK--ELKLQ 674
+++ E KLQ
Sbjct: 251 TVLRKEEEKLQ 261
Score = 36.6 bits (83), Expect = 0.079
Identities = 34/142 (23%), Positives = 68/142 (47%), Gaps = 9/142 (6%)
Query: 524 EDDKGKIMEEVMRTYLKQQEKLNLILQKKQQLQMEVKMLSSSKSMKELTEEQQNLQKELE 583
E+++ + +E+ + Q+ L +L ++Q+ E + + + EE+Q LE
Sbjct: 1246 ENEQFRQLEDSQLRDRQSQQDLQHLLGEQQERDREQERRRWQQRDRHFPEEEQ-----LE 1300
Query: 584 SLQNEHAQRMEEFYVEQKDLEKKLEQIMKQKCTCDSNLEKDKEAEYAGQLAELRQRLDHA 643
+ + A+R + E+K L ++ + +++ D K +E E Q E Q L
Sbjct: 1301 REEQKEAKRRDRKSQEEKQLLREEREEKRRRQETD---RKFREEEQLLQERE-EQPLRRQ 1356
Query: 644 EADRQELQDELRQEREARQKLE 665
E DR+ ++ELR + + R+ LE
Sbjct: 1357 ERDRKFREEELRHQEQGRKFLE 1378
Score = 36.2 bits (82), Expect = 0.10
Identities = 33/147 (22%), Positives = 72/147 (48%), Gaps = 12/147 (8%)
Query: 532 EEVMRTYLKQQEKLNLILQKKQQLQMEVKMLSSSKSMKELTEEQQNLQKELESLQNEHAQ 591
EE +QE+ L+++Q+ + + E +Q L+++ E + E
Sbjct: 430 EEERHEQKHEQERREQRLKREQEERRDWLKREEETERHEQERRKQQLKRDQEEERRERWL 489
Query: 592 RMEEFYVEQKDLEKKLEQIMK--QKCTCDSNLEKDKEAEYAGQLAELRQRLDHAEADRQE 649
++EE E+++ +++ EQ ++ Q+ + L++ +E E L+QRL + R+E
Sbjct: 490 KLEE--EERREQQERREQQLRREQEERREQRLKRQEEEE------RLQQRLRSEQQLRRE 541
Query: 650 LQDELRQ--EREARQKLEMMIKELKLQ 674
++ Q +RE ++LE +E +L+
Sbjct: 542 QEERREQLLKREEEKRLEQERREQRLK 568
Score = 35.8 bits (81), Expect = 0.13
Identities = 33/114 (28%), Positives = 59/114 (51%), Gaps = 10/114 (8%)
Query: 571 LTEEQQNLQKELESLQNEHAQRMEEFYVEQKD--LEKKLEQIMKQKCTCDSNLEKDKEAE 628
L EE++ ESL + Q ++ E +D LE++ Q +QK E+++E
Sbjct: 95 LDEEKRARCDGKESLLQDRRQEEDQRRFEPRDRQLEEEPGQRRRQK-----RQEQERELA 149
Query: 629 YAGQLAELRQRLDHAEADRQELQDEL-RQEREARQKLEMMIKELKLQILKSSKT 681
+ +E ++RL+ + DRQ +EL RQ +E +++ E +E +LQ K +T
Sbjct: 150 EGEEQSEKQERLE--QRDRQRRDEELWRQRQEWQEREERRAEEEQLQSCKGHET 201
Score = 35.0 bits (79), Expect = 0.23
Identities = 26/126 (20%), Positives = 65/126 (51%), Gaps = 3/126 (2%)
Query: 540 KQQEKLNLILQKKQQLQMEVKMLSSSKSMKELTEEQQNLQKELESLQNEHAQRMEEFYVE 599
++QE+ Q++++ Q E + + ++L EQ+ +++ + E +R ++ E
Sbjct: 308 RKQEEERREQQEERREQQERREQQEERREQQLRREQEERREQQLRREQEEERREQQLRRE 367
Query: 600 QKDLEKKLEQIMKQKCTCDSNLEKDKEAEYAGQLAELRQRLDHAEADRQELQDELRQERE 659
Q++ ++ + +Q+ + L ++++ QL Q+L + R+E Q LR+E++
Sbjct: 368 QEEERREQQLRREQQLRREQQLRREQQLRREQQLRR-EQQLRREQQLRREQQ--LRREQQ 424
Query: 660 ARQKLE 665
R++ E
Sbjct: 425 LRREQE 430
Score = 35.0 bits (79), Expect = 0.23
Identities = 34/171 (19%), Positives = 83/171 (48%), Gaps = 12/171 (7%)
Query: 522 ICEDDKGKIMEEVMRTYLKQQEKLNLILQKKQ-QLQMEVKMLSSSKSMKELTEEQQNLQK 580
+ E+++ + E + K Q +L +Q ++ + + +E E+++ +
Sbjct: 685 LAEEEQEQARERIKSRIPKWQWQLESEADARQSKVYSRPRKQEGQRRRQEQEEKRRRRES 744
Query: 581 ELESLQNEHAQRMEEFYVEQKDL------EKKLEQIMKQKCTCDSNLEKDKEAEYAGQLA 634
EL+ + E A R ++ +++D E+K E+ +Q+ + L + +E + A
Sbjct: 745 ELQWQEEERAHRQQQEEEQRRDFTWQWQAEEKSER-GRQRLSARPPLREQRERQLR---A 800
Query: 635 ELRQRLDHAEADRQELQDELRQEREARQK-LEMMIKELKLQILKSSKTAKE 684
E RQ+ + +E +++ R++R R+K L+ + +E +LQ + ++ +E
Sbjct: 801 EERQQREQRFLPEEEEKEQRRRQRREREKELQFLEEEEQLQRRERAQQLQE 851
Score = 35.0 bits (79), Expect = 0.23
Identities = 27/130 (20%), Positives = 65/130 (50%), Gaps = 3/130 (2%)
Query: 539 LKQQEKLNLILQKKQQLQMEV--KMLSSSKSMKELTEEQQNLQ-KELESLQNEHAQRMEE 595
+++QE+ L+++QQL+ E K + ++E E+Q + Q ++ + L+ E R +E
Sbjct: 1439 VRRQERERKFLEEEQQLRQERHRKFREEEQLLQEREEQQLHRQERDRKFLEEEQQLRRQE 1498
Query: 596 FYVEQKDLEKKLEQIMKQKCTCDSNLEKDKEAEYAGQLAELRQRLDHAEADRQELQDELR 655
+ ++ E + ++ ++ + L + + Q + +R + + RQ+ + R
Sbjct: 1499 RDRKFREQELRSQEPERKFLEEEQQLHRQQRQRKFLQEEQQLRRQERGQQRRQDRDRKFR 1558
Query: 656 QEREARQKLE 665
+E + RQ+ E
Sbjct: 1559 EEEQLRQERE 1568
Score = 34.7 bits (78), Expect = 0.30
Identities = 40/171 (23%), Positives = 83/171 (48%), Gaps = 28/171 (16%)
Query: 532 EEVMRTYLKQQEKLNLILQKKQQLQMEVKMLSSSKSMKELTEEQQNLQKELE-------- 583
+++ R +++ + L L+++++ + + + + +E EQ+ ++E E
Sbjct: 474 QQLKRDQEEERRERWLKLEEEERREQQERREQQLRREQEERREQRLKRQEEEERLQQRLR 533
Query: 584 ---SLQNEHAQRMEEFYVEQKDLEKKLEQIMK-------QKCTCDSNLEKDKEAEY---- 629
L+ E +R E+ +++ EK+LEQ + Q+ D L++++E
Sbjct: 534 SEQQLRREQEERREQLL--KREEEKRLEQERREQRLKREQEERRDQLLKREEERRQQRLK 591
Query: 630 AGQLAELRQRLDHAEADRQELQDELRQEREARQKLEMMIKELKLQILKSSK 680
Q L QRL E +R E Q+E R++R R++ E +E + Q+LKS +
Sbjct: 592 REQEERLEQRLKREEVERLE-QEERREQRLKREEPE---EERRQQLLKSEE 638
Score = 34.3 bits (77), Expect = 0.39
Identities = 31/143 (21%), Positives = 67/143 (46%), Gaps = 3/143 (2%)
Query: 541 QQEKLNLILQKKQQLQMEVKMLSSSKSMKELTEEQQNLQKELESLQNEHAQRMEEFYVEQ 600
++E+L Q ++ L+ E ++ + K L EEQQ +E E Q R +F E+
Sbjct: 1363 REEELRHQEQGRKFLEEEQRLRRQERERKFLKEEQQLRCQERE--QQLRQDRDRKFREEE 1420
Query: 601 KDLEKKLEQIMKQKCTCDSNLEKDKEAEYAGQLAELRQRLDHAEADRQELQDELRQEREA 660
+ L ++ E+ K + +++E ++ + +LRQ + ++L E +++
Sbjct: 1421 QQLSRQ-ERDRKFREEEQQVRRQERERKFLEEEQQLRQERHRKFREEEQLLQEREEQQLH 1479
Query: 661 RQKLEMMIKELKLQILKSSKTAK 683
RQ+ + E + Q+ + + K
Sbjct: 1480 RQERDRKFLEEEQQLRRQERDRK 1502
Score = 33.9 bits (76), Expect = 0.51
Identities = 27/154 (17%), Positives = 77/154 (50%), Gaps = 11/154 (7%)
Query: 519 KDVICEDDKGKIMEEVMRTYLKQQEKLNLILQKKQQLQMEVKMLSSSKSMKELTEEQQNL 578
++ + +++ K +E R Y +++E L QK++Q + S K E +E
Sbjct: 1180 EEQLLREEQEKRRQERERQYREEEE---LQRQKRKQRYRDEDQRSDLKWQWEPEKENAVR 1236
Query: 579 QKEL--ESLQNEHAQRMEEFYVEQKDLEKKLEQIMKQKCTCDSNLEKDKEAEYAGQLAEL 636
++ + +NE +++E+ + + ++ L+ ++ ++ E+D+E E
Sbjct: 1237 DNKVYCKGRENEQFRQLEDSQLRDRQSQQDLQHLLGEQ------QERDREQERRRWQQRD 1290
Query: 637 RQRLDHAEADRQELQDELRQEREARQKLEMMIKE 670
R + + +R+E ++ R++R+++++ +++ +E
Sbjct: 1291 RHFPEEEQLEREEQKEAKRRDRKSQEEKQLLREE 1324
Score = 33.9 bits (76), Expect = 0.51
Identities = 32/158 (20%), Positives = 80/158 (50%), Gaps = 5/158 (3%)
Query: 532 EEVMRTYLKQQEKLNLILQKKQQLQMEVKMLSSSKSMKELTEEQQNLQKELESLQNEHAQ 591
+E R +L+++ +L +++Q + + + + EEQQ ++E + E Q
Sbjct: 1639 QERDRKFLEEEPQLRRQEREQQLRHDRDRKFREEEQLLQEGEEQQLRRQERDRKFREEEQ 1698
Query: 592 RMEEFYVEQKDLEKKLE---QIMKQKCTCDSNLEKDKEAEYAGQLAELRQRLDHAEADRQ 648
++ E+K L+++ + Q +++K + L ++ E E + R+ L+ + +
Sbjct: 1699 QLRRQERERKFLQEEQQLRRQELERKFREEEQLRQETEQEQLRRQERYRKILEEEQLRPE 1758
Query: 649 ELQDEL-RQEREAR-QKLEMMIKELKLQILKSSKTAKE 684
+ +L RQER+ + ++ E + +E + Q L+S ++ ++
Sbjct: 1759 REEQQLRRQERDRKFREEEQLRQEREEQQLRSQESDRK 1796
Score = 32.7 bits (73), Expect = 1.1
Identities = 34/152 (22%), Positives = 72/152 (47%), Gaps = 17/152 (11%)
Query: 540 KQQEKLNLILQKKQQLQMEV--KMLSSSKSMKELTEEQQNLQK----ELESLQNEHAQRM 593
+Q EK + Q+ +Q + E + + +E E++ LQ E E +E R
Sbjct: 153 EQSEKQERLEQRDRQRRDEELWRQRQEWQEREERRAEEEQLQSCKGHETEEFPDEEQLRR 212
Query: 594 EEFY-VEQKDLEKKLEQIMKQKCTCDSNLEKDKEAEYAGQLAELRQRLDHAEADRQELQD 652
E + +K E+K +Q +++ D ++++E E+ + LR+ + ++LQ+
Sbjct: 213 RELLELRRKGREEKQQQRRERQ---DRVFQEEEEKEWRKRETVLRK-------EEEKLQE 262
Query: 653 ELRQEREARQKLEMMIKELKLQILKSSKTAKE 684
E Q + Q+ E +++L+ Q L+ + +E
Sbjct: 263 EEPQRQRELQEEEEQLRKLERQELRRERQEEE 294
Score = 32.7 bits (73), Expect = 1.1
Identities = 37/177 (20%), Positives = 93/177 (52%), Gaps = 18/177 (10%)
Query: 519 KDVICEDDKGKIMEEVMRTYLK--QQEKLNLILQKKQQL-QMEVKMLSSSKSMKELT-EE 574
+ ++ +++ ++ +E LK Q+E+ + +L+++++ Q +K + + L EE
Sbjct: 547 EQLLKREEEKRLEQERREQRLKREQEERRDQLLKREEERRQQRLKREQEERLEQRLKREE 606
Query: 575 QQNLQKE------LESLQNEHAQRMEEFYVEQKDLEKKLEQIMKQKCTCDSNLEKDKEAE 628
+ L++E L+ + E +R + E+++ ++ + +Q+ + L++++E E
Sbjct: 607 VERLEQEERREQRLKREEPEEERRQQLLKSEEQEERRQQQLRREQQERREQRLKREEEEE 666
Query: 629 YAGQLAELRQRLDHAEADR-QELQDELRQEREARQKLEMMIKELKLQILKSSKTAKE 684
E R + +H E R QEL +E ++ +AR++++ I + + Q L+S A++
Sbjct: 667 ----RLEQRLKREHEEERREQELAEE--EQEQARERIKSRIPKWQWQ-LESEADARQ 716
Score = 32.7 bits (73), Expect = 1.1
Identities = 34/143 (23%), Positives = 74/143 (51%), Gaps = 14/143 (9%)
Query: 539 LKQQEKLNLILQKKQQLQMEVKMLSSSKSMKELTEEQ--QNLQKELESLQNEHAQRMEEF 596
L+++E+ L Q++ + E ++ + K L EEQ + ++E + L+ E R +E
Sbjct: 1345 LQEREEQPLRRQERDRKFREEELRHQEQGRKFLEEEQRLRRQERERKFLKEEQQLRCQE- 1403
Query: 597 YVEQKDLEKKLEQIMKQKCTCDSNLEKDKEAEYAGQLAELRQRLDHAEADRQELQDE--L 654
++ L + ++ +++ S E+D+ + E Q++ E +R+ L++E L
Sbjct: 1404 --REQQLRQDRDRKFREEEQQLSRQERDR------KFREEEQQVRRQERERKFLEEEQQL 1455
Query: 655 RQEREAR-QKLEMMIKELKLQIL 676
RQER + ++ E +++E + Q L
Sbjct: 1456 RQERHRKFREEEQLLQEREEQQL 1478
>gi|31982906 cingulin-like 1 [Homo sapiens]
Length = 1302
Score = 53.9 bits (128), Expect = 5e-07
Identities = 66/280 (23%), Positives = 133/280 (47%), Gaps = 44/280 (15%)
Query: 416 TSAVSQSKELTKTEASKSISRQSEKAHSSGKLQKTVSYPDVSLEEQEKMDLKTSRELCSR 475
T+ + T T + S K S T + PD+ L+ Q+++ +T+ E +
Sbjct: 501 TATLMLQNRATATSPDSGAKKISVKTFPSAS--NTQATPDL-LKGQQELTQQTNEETAKQ 557
Query: 476 L------DASISNNSTSKRKSESATCNLVRDINKVGIGLVAAASSPLLVKDVICEDDKGK 529
+ + S N+ +KRK NLV + + L + A+ + C
Sbjct: 558 ILYNYLKEGSTDNDDATKRK-----VNLVFEKIQT---LKSRAAGSAQGNNQACNSTSE- 608
Query: 530 IMEEVMRTYLKQQEKLNL-ILQKKQQLQMEVKMLSSSKSMKELTEEQQNLQKELESLQNE 588
++ L+Q+ KL + + + ++QLQ+EVK + + + EE++ ++ LE L+++
Sbjct: 609 -----VKDLLEQKSKLTIEVAELQRQLQLEVK------NQQNIKEERERMRANLEELRSQ 657
Query: 589 HAQRMEEFYVEQKDLE-------KKLEQIMKQKCTCDSNLEKDKEAEYAGQLAELRQRLD 641
H +++EE Q+ LE K LE++ + K + + + ++ + QL+E+ LD
Sbjct: 658 HNEKVEENSTLQQRLEESEGELRKNLEELFQVKMEREQHQTEIRDLQ--DQLSEMHDELD 715
Query: 642 HAE--ADRQE--LQDELRQEREARQKLEMMIKELKLQILK 677
A+ DR++ L +EL Q ++ Q L ++ KE + +L+
Sbjct: 716 SAKRSEDREKGALIEELLQAKQDLQDL-LIAKEEQEDLLR 754
Score = 47.8 bits (112), Expect = 3e-05
Identities = 69/262 (26%), Positives = 114/262 (43%), Gaps = 30/262 (11%)
Query: 436 RQSEKAHSSGKLQKTVSYPDVS---LEEQEKMDLKTSRELCSRLD------ASISNNSTS 486
R+ E G L++ VS D L+EQ +L+ RE AS SN S
Sbjct: 756 RERELTALKGALKEEVSSHDQEMDKLKEQYDAELQALRESVEEATKNVEVLASRSNTSEQ 815
Query: 487 KRKSESATCNLVRDINKVGIGLVAAASSPLLVKDVICEDDKGKIMEEVMRTYLKQQEKLN 546
+ L+++ N+ G + ED KG E + LK+ E
Sbjct: 816 DQAGTEMRVKLLQEENEKLQGRSEELERRVAQLQRQIEDLKGD--EAKAKETLKKYEG-- 871
Query: 547 LILQKKQQLQMEVKMLSSSKSMKELTEEQQNLQKELESLQNEHAQRMEEFYVEQKDLEKK 606
+ Q+E ++ + K KE ++ L+ ELE+ Q +Q + EQK L +K
Sbjct: 872 ------EIRQLEEALVHARKEEKEAVSARRALENELEAAQGNLSQTTQ----EQKQLSEK 921
Query: 607 LEQIMKQKCTCDS-NLEKDKEAEYAGQLAELRQR--LDHAEADRQ---ELQDELRQEREA 660
L++ +QK E + E + G+ E Q+ D EA R ELQ++L + +E
Sbjct: 922 LKEESEQKEQLRRLKNEMENERWHLGKTIEKLQKEMADIVEASRTSTLELQNQLDEYKEK 981
Query: 661 -RQKLEMMIKELKLQILKSSKT 681
R++L M ++LK + L++ K+
Sbjct: 982 NRRELAEMQRQLKEKTLEAEKS 1003
Score = 47.4 bits (111), Expect = 4e-05
Identities = 78/391 (19%), Positives = 165/391 (42%), Gaps = 77/391 (19%)
Query: 341 EKKLKIILEEMKEKFSMRSGKRN------QSKTDAPSGMELQSWYPVIKQEGDHVSQTHS 394
E ++K++ EE EK RS + Q + + G E ++ + K EG+ +
Sbjct: 821 EMRVKLLQEE-NEKLQGRSEELERRVAQLQRQIEDLKGDEAKAKETLKKYEGEIRQLEEA 879
Query: 395 FLHP--------SYYLYMCDKVVAPNVSLTSAVSQSKELTK-----TEASKSISR-QSEK 440
+H S + +++ A +L+ + K+L++ +E + + R ++E
Sbjct: 880 LVHARKEEKEAVSARRALENELEAAQGNLSQTTQEQKQLSEKLKEESEQKEQLRRLKNEM 939
Query: 441 AHSSGKLQKTVSYPDVSLEEQEKMDLKTSRELCSRLDASISNNSTSKRKSESATCNLVRD 500
+ L KT+ + + + ++ EL ++LD K K+ + R
Sbjct: 940 ENERWHLGKTIEKLQKEMADIVEASRTSTLELQNQLDEY-------KEKNRRELAEMQRQ 992
Query: 501 INKVGIGLVAAASSPLLVKDVICEDDKGKIMEEVMRTYLKQQE----KLNLILQKKQQLQ 556
+ + + + + + ++D + ++MEE +R Y + Q+ K L+ Q + L+
Sbjct: 993 LKEKTLEAEKSRLTAMKMQDEM------RLMEEELRDYQRAQDEALTKRQLLEQTLKDLE 1046
Query: 557 MEVKMLSS-----SKSMKELTEEQQNLQKELESLQNEH---AQRMEEFYVEQKDLEKKL- 607
E++ S S+ +K++ ++ L+ ELE +N ++R+ + + L +L
Sbjct: 1047 YELEAKSHLKDDRSRLVKQMEDKVSQLEMELEEERNNSDLLSERISRSREQMEQLRNELL 1106
Query: 608 -EQIMKQKCTCDS-NLEKDKE---------------------AEYAGQLAELRQRLDHAE 644
E+ +Q CD +LE+ + + ++AEL RL+ E
Sbjct: 1107 QERAARQDLECDKISLERQNKDLKSRIIHLEGSYRSSKEGLVVQMEARIAELEDRLESEE 1166
Query: 645 ADRQELQDELRQEREARQKLEMMIKELKLQI 675
DR LQ + ++LE +KEL +Q+
Sbjct: 1167 RDRANLQ-------LSNRRLERKVKELVMQV 1190
Score = 42.4 bits (98), Expect = 0.001
Identities = 51/193 (26%), Positives = 92/193 (47%), Gaps = 33/193 (17%)
Query: 524 EDDKGKIMEEVMRTYLKQQEKLNLILQKKQ------QLQMEVKMLSSSKSM---KELTEE 574
+ + I+E + L+ Q +L+ +K + Q Q++ K L + KS ++ +E
Sbjct: 954 QKEMADIVEASRTSTLELQNQLDEYKEKNRRELAEMQRQLKEKTLEAEKSRLTAMKMQDE 1013
Query: 575 QQNLQKELESLQNEHAQRM-EEFYVEQ--KDLEKKLE----------QIMKQKCTCDSNL 621
+ +++EL Q + + + +EQ KDLE +LE +++KQ S L
Sbjct: 1014 MRLMEEELRDYQRAQDEALTKRQLLEQTLKDLEYELEAKSHLKDDRSRLVKQMEDKVSQL 1073
Query: 622 EKDKEAEYAGQLAELRQRLDHAEADRQELQDELRQEREARQ-------KLEMMIKELKLQ 674
E + E E L +R+ + ++L++EL QER ARQ LE K+LK +
Sbjct: 1074 EMELEEE-RNNSDLLSERISRSREQMEQLRNELLQERAARQDLECDKISLERQNKDLKSR 1132
Query: 675 ILK---SSKTAKE 684
I+ S +++KE
Sbjct: 1133 IIHLEGSYRSSKE 1145
Score = 42.0 bits (97), Expect = 0.002
Identities = 77/374 (20%), Positives = 146/374 (39%), Gaps = 54/374 (14%)
Query: 338 TPEEKKLKIILEEMKEKFSMRSGKRNQSKTDAPSGMELQSWYPVIKQEGDHVSQTHSFLH 397
T E+K+L L+E E+ +N+ ME + W H+ +T L
Sbjct: 912 TQEQKQLSEKLKEESEQKEQLRRLKNE--------MENERW---------HLGKTIEKLQ 954
Query: 398 PSYYLYMCDKVVAPNVS---LTSAVSQSKELTKTEASKSISRQSEKAHSSGKLQKTVS-- 452
M D V A S L + + + KE + E ++ + EK + K + T
Sbjct: 955 KE----MADIVEASRTSTLELQNQLDEYKEKNRRELAEMQRQLKEKTLEAEKSRLTAMKM 1010
Query: 453 YPDVSLEEQEKMDLK-------TSRELCSRLDASISNNSTSKRKSESATCNLVRDINKVG 505
++ L E+E D + T R+L + + +K + LV+ +
Sbjct: 1011 QDEMRLMEEELRDYQRAQDEALTKRQLLEQTLKDLEYELEAKSHLKDDRSRLVKQMEDKV 1070
Query: 506 IGLVAAASSPLLVKDVICED-DKGKIMEEVMRTYLKQQ---------EKLNLILQKKQQL 555
L D++ E + + E +R L Q+ +K++L Q K
Sbjct: 1071 SQLEMELEEERNNSDLLSERISRSREQMEQLRNELLQERAARQDLECDKISLERQNKDLK 1130
Query: 556 QMEVKMLSSSKSMKE-LTEEQQNLQKELESLQNEHAQRMEEFYVEQKDLEKKLEQIMKQK 614
+ + S +S KE L + + ELE + + + LE+K+++++ Q
Sbjct: 1131 SRIIHLEGSYRSSKEGLVVQMEARIAELEDRLESEERDRANLQLSNRRLERKVKELVMQV 1190
Query: 615 CTCDSNLEKDKEA------EYAGQLAELRQRLDHAEADRQELQDELRQEREARQKLE--- 665
+L K+ Q+ E + +D E+ +++LQ EL ++ + + L+
Sbjct: 1191 DDEHLSLTDQKDQLSLRLKAMKRQVEEAEEEIDRLESSKKKLQRELEEQMDMNEHLQGQL 1250
Query: 666 -MMIKELKLQILKS 678
M K+L+L+ L S
Sbjct: 1251 NSMKKDLRLKKLPS 1264
>gi|148596984 golgi autoantigen, golgin subfamily b, macrogolgin (with
transmembrane signal), 1 [Homo sapiens]
Length = 3259
Score = 53.9 bits (128), Expect = 5e-07
Identities = 42/173 (24%), Positives = 89/173 (51%), Gaps = 24/173 (13%)
Query: 536 RTYLKQQEKLNLILQKKQQLQMEVKMLSSSKSMK----ELTEEQQNLQKELESLQNEHAQ 591
R L Q+E+ LI + + L + SS +S+K LTE+++ L KE+ESL++
Sbjct: 1540 RLALLQEERDKLITEMDRSLLENQSLSSSCESLKLALEGLTEDKEKLVKEIESLKSSKIA 1599
Query: 592 RMEEFYVEQKDLEKKLEQIMKQKCTCDSNLE---------KDKEAEYAGQL-------AE 635
E+ + K+L+K+ E +++ + E + ++ E G+L E
Sbjct: 1600 ESTEWQEKHKELQKEYEILLQSYENVSNEAERIQHVVEAVRQEKQELYGKLRSTEANKKE 1659
Query: 636 LRQRLDHAEADRQELQDELRQEREARQKLEMMIKE----LKLQILKSSKTAKE 684
++L AE + +E+++++R+ +++Q+ + ++E L+ ++ + TAKE
Sbjct: 1660 TEKQLQEAEQEMEEMKEKMRKFAKSKQQKILELEEENDRLRAEVHPAGDTAKE 1712
Score = 46.6 bits (109), Expect = 8e-05
Identities = 70/342 (20%), Positives = 137/342 (40%), Gaps = 78/342 (22%)
Query: 404 MCDKVVAPNVSLTSAVSQSK--------ELTKTEAS--------KSISRQSEKA-HSSGK 446
+CD + N L S + +++ EL K E+ +S EK G
Sbjct: 2278 VCDTLQGENKELLSQLEETRHLYHSSQNELAKLESELKSLKDQLTDLSNSLEKCKEQKGN 2337
Query: 447 LQKTVSYPDVSLE------EQEKMDLKTSRELCSRLDASISNNS-------TSKRKSESA 493
L+ + + ++ EQ + DL+ SREL SRL I+ + K ++
Sbjct: 2338 LEGIIRQQEADIQNSKFSYEQLETDLQASRELTSRLHEEINMKEQKIISLLSGKEEAIQV 2397
Query: 494 TCNLVRDINKVGIGLVAAASSPLLVKDVICEDDKGKIMEEVMRTYLKQQEKLNLILQKKQ 553
+R + I + S ++++ E++ K +++ + E L I KK+
Sbjct: 2398 AIAELRQQHDKEIKELENLLSQEEEENIVLEEENKKAVDKTNQL----METLKTI--KKE 2451
Query: 554 QLQMEVKMLSSSKSM---------------------------------------KELTEE 574
+Q + ++ S KSM +L EE
Sbjct: 2452 NIQQKAQLDSFVKSMSSLQNDRDRIVGDYQQLEERHLSIILEKDQLIQEAAAENNKLKEE 2511
Query: 575 QQNLQKELESLQNEHAQRMEEFYVEQKDLEKKLE-QIMKQKCTCDSNLEKDKEAEYAGQL 633
+ L+ ++ L +E+A+ E ++DL + + + +QK + L+++KE E +
Sbjct: 2512 IRGLRSHMDDLNSENAKLDAELIQYREDLNQVITIKDSQQKQLLEVQLQQNKELE--NKY 2569
Query: 634 AELRQRLDHAEADRQELQDELRQEREARQKLEMMIKELKLQI 675
A+L ++L +E ++L+ +E +Q L I+ LK+ I
Sbjct: 2570 AKLEEKLKESEEANEDLRRSFNALQEEKQDLSKEIESLKVSI 2611
Score = 45.8 bits (107), Expect = 1e-04
Identities = 65/314 (20%), Positives = 132/314 (42%), Gaps = 55/314 (17%)
Query: 407 KVVAPNVSLTSAVSQSKELTKTEASKS---ISRQSEKAHSSGKLQKTVSYPDVSLEEQEK 463
+V+A N+ L + +KE K++ + + R+ E+A +K QEK
Sbjct: 2093 RVLADNLKLKKELQSNKESVKSQMKQKDEDLERRLEQAEEKHLKEKK--------NMQEK 2144
Query: 464 MDLKTSRELCSRLDASISNNSTSKRKSESATCNLVRDINKVGIGLVAAASSPLLVKDVIC 523
+D ++ L+ +I + K + L +++ L A S +
Sbjct: 2145 LDALRREKV--HLEETIGEIQVTLNKKDKEVQQLQENLDSTVTQLAAFTKSMSSL----- 2197
Query: 524 EDDKGKIMEEVMRTYLKQQEKL------------NLILQKKQQLQMEVKM------LSSS 565
+DD+ ++++E + K + + N + K Q QM + M +S
Sbjct: 2198 QDDRDRVIDEAKKWERKFSDAIQSKEEEIRLKEDNCSVLKDQLRQMSIHMEELKINISRL 2257
Query: 566 KSMKELTE-----EQQNLQKELESLQNEHAQRMEE-------FYVEQKDL---EKKLEQI 610
+ K++ E E Q QK ++LQ E+ + + + ++ Q +L E +L+ +
Sbjct: 2258 EHDKQIWESKAQTEVQLQQKVCDTLQGENKELLSQLEETRHLYHSSQNELAKLESELKSL 2317
Query: 611 MKQKCTCDSNLEKDKE--AEYAGQLAELRQRLDHAEADRQELQDELRQEREARQKL--EM 666
Q ++LEK KE G + + + +++ ++L+ +L+ RE +L E+
Sbjct: 2318 KDQLTDLSNSLEKCKEQKGNLEGIIRQQEADIQNSKFSYEQLETDLQASRELTSRLHEEI 2377
Query: 667 MIKELKLQILKSSK 680
+KE K+ L S K
Sbjct: 2378 NMKEQKIISLLSGK 2391
Score = 43.1 bits (100), Expect = 8e-04
Identities = 77/377 (20%), Positives = 157/377 (41%), Gaps = 53/377 (14%)
Query: 341 EKKLKIILEEMKEKFSMRSGKRNQSKTDAPSGMELQSWYPVIKQEGDHVSQTHSFLHPSY 400
E+ + I E +E+ S+ R PS +S P + ++ + ++
Sbjct: 1787 EEGTQSIPGETEEQDSLSMSTRPTCSESVPSA---KSANPAVSKDFSSHDEINN------ 1837
Query: 401 YLYMCDKVVAPNVSLTSAVSQSKELTKTEASKSISRQSEKAHSSGKLQKTVSYPDVSLEE 460
YL D++ L ++KE ++T ++ + S+ + G+L+ + EE
Sbjct: 1838 YLQQIDQLKERIAGLEEEKQKNKEFSQTLENEKNTLLSQISTKDGELK-------MLQEE 1890
Query: 461 QEKMDLKTSR--ELCSRLDASISNNSTSKRKSESATCNLVRDINKVGIGLVAAASSPLLV 518
KM+L + E SR+ K E N + ++N IG + +
Sbjct: 1891 VTKMNLLNQQIQEELSRVTKLKETAEEEKDDLEERLMNQLAELNG-SIGNYCQDVTDAQI 1949
Query: 519 KDVICEDDKGKI------MEEVMRTYLKQQEKLNL-----ILQKKQQLQMEVKMLSSSKS 567
K+ + E + + +EE + +K++ K+ L+K Q Q E S +K
Sbjct: 1950 KNELLESEMKNLKKCVSELEEEKQQLVKEKTKVESEIRKEYLEKIQGAQKEPGNKSHAKE 2009
Query: 568 MKELTEEQQNLQKELE----------SLQNEHAQRMEEFYVE-QKDLE---KKLEQIMKQ 613
++EL +E+Q K+L+ S + +E E QKDLE + L Q ++
Sbjct: 2010 LQELLKEKQQEVKQLQKDCIRYQEKISALERTVKALEFVQTESQKDLEITKENLAQAVEH 2069
Query: 614 KCTCDSNLEK------DKEAEYAGQLAELRQRLDHAEADRQELQDELRQEREARQKLEMM 667
+ + L D ++E A LA+ + +++++ ++ +++Q+ E LE
Sbjct: 2070 RKKAQAELASFKVLLDDTQSEAARVLADNLKLKKELQSNKESVKSQMKQKDE---DLERR 2126
Query: 668 IKELKLQILKSSKTAKE 684
+++ + + LK K +E
Sbjct: 2127 LEQAEEKHLKEKKNMQE 2143
Score = 41.2 bits (95), Expect = 0.003
Identities = 57/264 (21%), Positives = 116/264 (43%), Gaps = 37/264 (14%)
Query: 415 LTSAVSQSKELTKTEASKSISRQSEKAHSSGKLQKTVSYPD-----VSLEEQEKMDLKTS 469
L+ A+SQ KEL T+ + + EK LQ+T+ D +S EKM
Sbjct: 864 LSQALSQ-KELEITKMDQLLL---EKKRDVETLQQTIEEKDQQVTEISFSMTEKMVQLNE 919
Query: 470 RELCSRLDA-SISNNSTSKRKSESATCNLVRDINKVGIGLVAAASSPLLVKDVICEDDKG 528
+ ++ ++ ++E A V + N+V GL G
Sbjct: 920 EKFSLGVEIKTLKEQLNLLSRAEEAKKEQVEEDNEVSSGLKQNYDEM---------SPAG 970
Query: 529 KIMEEVMRTYLKQQEKLNLILQKKQQLQMEVKMLSSSKSMKELTEEQQNLQKELESLQNE 588
+I +E + Q + +L+ KK+ Q + K+ ++ + KEL + L++EL +L++E
Sbjct: 971 QISKEEL------QHEFDLL--KKENEQRKRKLQAALINRKELLQRVSRLEEELANLKDE 1022
Query: 589 HAQRMEEFYVEQKDLEK-KLEQIMKQKCTCDSNLEKDKEAEYAGQLAELRQRLDHAEADR 647
+ + E+ ++E+ K + +KC K +E E L+Q + E +
Sbjct: 1023 SKKEIPLSETERGEVEEDKENKEYSEKCV----TSKCQEIE-----IYLKQTISEKEVEL 1073
Query: 648 QELQDELRQEREARQKLEMMIKEL 671
Q ++ +L ++ A ++ + ++K++
Sbjct: 1074 QHIRKDLEEKLAAEEQFQALVKQM 1097
Score = 40.4 bits (93), Expect = 0.005
Identities = 53/240 (22%), Positives = 106/240 (44%), Gaps = 33/240 (13%)
Query: 461 QEKMDLKTSRELCSRLDASISNNSTSKRKSESATCNLVRDINKVGIGLVAAASSPLLVKD 520
Q K LK L+ +S+ ++ K L INK G+ + + + +
Sbjct: 1306 QIKAQLKEIEAEKVELELKVSSTTSELTKKSEEVFQLQEQINKQGLE-IESLKTVSHEAE 1364
Query: 521 VICEDDKGKIME--------EVMRTYLKQQEKLNLILQKKQQLQMEVKMLSSSKSMKE-- 570
V E + K+ E +R + ++L ++ KK++ +V LS S KE
Sbjct: 1365 VHAESLQQKLESSQLQIAGLEHLRELQPKLDELQKLISKKEE---DVSYLSGQLSEKEAA 1421
Query: 571 LTE------EQQNLQK----ELESLQNEHAQRMEEFYVEQKDLEKKLEQIMKQKCTCDSN 620
LT+ EQ++L K +LE EH +R+++ VE ++++K E+I + +S
Sbjct: 1422 LTKIQTEIIEQEDLIKALHTQLEMQAKEHDERIKQLQVELCEMKQKPEEIGE-----ESR 1476
Query: 621 LEKDKEAEYAGQLAELRQRLDHAEADRQELQDELRQEREARQKLEMMIKELKLQILKSSK 680
++ + + L ++ L + + LQ+EL R ++L + +++ Q+ +K
Sbjct: 1477 AKQQIQRKLQAALISRKEAL----KENKSLQEELSLARGTIERLTKSLADVESQVSAQNK 1532
Score = 38.5 bits (88), Expect = 0.021
Identities = 79/361 (21%), Positives = 156/361 (43%), Gaps = 45/361 (12%)
Query: 340 EEKKLKIILEEMKEKFSMRSGKRNQSKTDAPSGMELQSWYPVIKQEGDHVSQTHSFLHPS 399
+++ L+ LE+ +EK ++ K Q K DA +++E H+ +T + +
Sbjct: 2119 KDEDLERRLEQAEEKH-LKEKKNMQEKLDA------------LRREKVHLEETIGEIQVT 2165
Query: 400 YYLYMCDKVVAP-NVSLTSAVSQSKELTKTEASKSISRQSEKAHSSGKLQKTVSYPDVSL 458
L DK V +L S V+Q TK+ +S R + +K + D
Sbjct: 2166 --LNKKDKEVQQLQENLDSTVTQLAAFTKSMSSLQDDRDRVIDEAKKWERK---FSDAIQ 2220
Query: 459 EEQEKMDLKTSRELCSRLDASISNNSTSKRKSESATCNLVRDINKVGIGLVAAASSPLLV 518
++E++ LK CS L + S + + L D + A + + +
Sbjct: 2221 SKEEEIRLKEDN--CSVLKDQLRQMSIHMEELKINISRLEHDKQI----WESKAQTEVQL 2274
Query: 519 KDVICEDDKGKI------MEEVMRTYLKQQEKLNLILQKKQQLQMEVKMLSSSKSMKELT 572
+ +C+ +G+ +EE Y Q +L + + + L+ ++ LS+S +++
Sbjct: 2275 QQKVCDTLQGENKELLSQLEETRHLYHSSQNELAKLESELKSLKDQLTDLSNS--LEKCK 2332
Query: 573 EEQQNLQ----KELESLQNEHA--QRMEEFYVEQKDLEKKLEQIMKQKCTCDSNLEKDKE 626
E++ NL+ ++ +QN +++E ++L +L + + K +L KE
Sbjct: 2333 EQKGNLEGIIRQQEADIQNSKFSYEQLETDLQASRELTSRLHEEINMKEQKIISLLSGKE 2392
Query: 627 AEYAGQLAELRQRLDHAEADRQELQDELRQEREARQKLEMMIK---ELKLQILKSSKTAK 683
+AELRQ+ D + +EL++ L QE E LE K + Q++++ KT K
Sbjct: 2393 EAIQVAIAELRQQHD---KEIKELENLLSQEEEENIVLEEENKKAVDKTNQLMETLKTIK 2449
Query: 684 E 684
+
Sbjct: 2450 K 2450
Score = 37.7 bits (86), Expect = 0.035
Identities = 59/290 (20%), Positives = 121/290 (41%), Gaps = 44/290 (15%)
Query: 419 VSQSKELTKTEASKSISRQSEK-AHSSGKLQKTVSYPDVSLEEQEKMDLKTSRELCSRLD 477
+ + +EL T ++ Q+E+ A SS ++++ V K L+ E S L
Sbjct: 153 LQEKEELISTLQAQLTQAQAEQPAQSSTEMEEFVMM---------KQQLQEKEEFISTLQ 203
Query: 478 ASISNNSTSKRKSESATCNLVRDINKVGIGLVAAASSPLLVKDVICEDDKGKIMEEVMRT 537
A +S ++E A +VR+ + V LL ++ + D M++ +R
Sbjct: 204 AQLSQT-----QAEQAAQQVVREKDARFETQVRLHEDELL--QLVTQADVETEMQQKLRV 256
Query: 538 YLKQ------------------QEKLNLILQKKQQLQMEVKMLSSSKSMKELTEEQQNLQ 579
++ Q++L Q+ Q L +++ + + + T E + +
Sbjct: 257 LQRKLEEHEESLVGRAQVVDLLQQELTAAEQRNQILSQQLQQMEAEHNTLRNTVETEREE 316
Query: 580 KE--LESLQNEHAQRMEEFYVEQKDLEKKLEQIMKQKCTCDSNLEKDKEAEYAGQLAELR 637
+ LE ++ E A+R F+ Q+++ LEQ +Q + LE A AE+
Sbjct: 317 SKILLEKMELEVAERKLSFHNLQEEMHHLLEQ-FEQAGQAQAELESRYSALEQKHKAEME 375
Query: 638 QRLDH---AEADRQELQDELRQEREARQKLEMMIKELKLQILKSSKTAKE 684
++ H + QELQ ++ KL +++ Q ++S++T ++
Sbjct: 376 EKTSHILSLQKTGQELQSACDALKDQNSKL---LQDKNEQAVQSAQTIQQ 422
Score = 36.2 bits (82), Expect = 0.10
Identities = 33/175 (18%), Positives = 80/175 (45%), Gaps = 31/175 (17%)
Query: 526 DKGKIMEEVMRTYLKQQEKLNLI---------LQKKQQLQMEVKMLSSSKSMKELTEEQQ 576
+K + ++++ + ++ QEK++ + +Q + Q +E+ + +++ + E ++
Sbjct: 2016 EKQQEVKQLQKDCIRYQEKISALERTVKALEFVQTESQKDLEI----TKENLAQAVEHRK 2071
Query: 577 NLQKELESL-------QNEHAQRMEEFYVEQKDLEKKLEQIMKQKCTCDSNLEKDKEAEY 629
Q EL S Q+E A+ + + +K+L+ E + Q D +LE+
Sbjct: 2072 KAQAELASFKVLLDDTQSEAARVLADNLKLKKELQSNKESVKSQMKQKDEDLER------ 2125
Query: 630 AGQLAELRQRLDHAEADRQELQDELRQEREARQKLEMMIKELKLQILKSSKTAKE 684
L Q + +++ +Q++L R + LE I E+++ + K K ++
Sbjct: 2126 -----RLEQAEEKHLKEKKNMQEKLDALRREKVHLEETIGEIQVTLNKKDKEVQQ 2175
Score = 35.8 bits (81), Expect = 0.13
Identities = 56/256 (21%), Positives = 103/256 (40%), Gaps = 40/256 (15%)
Query: 435 SRQSEKAHSSGKLQKTVSYPDVSLEEQEKMDLKTSRELCSRLDASISNNSTSKRKSESAT 494
S Q+ + H++ +L + D SL+E + LK L DA +S + S +E +
Sbjct: 2742 SLQNSRDHANEELDELKRKYDASLKELAQ--LKEQGLLNRERDALLSETAFSMNSTEENS 2799
Query: 495 CNLVRDINKVGIGLVAAASSPLLVKDVICEDDKGKIME--EVMRTYLKQQEKLNLILQK- 551
+ + +N+ + + LL ED ++ + M + +++ L L+K
Sbjct: 2800 LSHLEKLNQQ----LLSKDEQLLHLSSQLEDSYNQVQSFSKAMASLQNERDHLWNELEKF 2855
Query: 552 -----------KQQLQMEVKMLSSSKSMKELTEEQQNLQKELESLQNEHAQRMEEFYVEQ 600
Q ++ S K+M L ++ L KEL++LQ ++ Q +E E
Sbjct: 2856 RKSEEGKQRSAAQPSTSPAEVQSLKKAMSSLQNDRDRLLKELKNLQQQYLQINQEI-TEL 2914
Query: 601 KDLEKKLEQIMKQKCTCDSNLEKDKEAEYAGQLAELRQRLDHAEADRQELQDELRQEREA 660
L+ +L++ +DK + ELRQ + Q EL Q R
Sbjct: 2915 HPLKAQLQEY------------QDKTKAFQIMQEELRQ-------ENLSWQHELHQLRME 2955
Query: 661 RQKLEMMIKELKLQIL 676
+ E+ + +K Q L
Sbjct: 2956 KSSWEIHERRMKEQYL 2971
Score = 35.4 bits (80), Expect = 0.18
Identities = 30/114 (26%), Positives = 51/114 (44%), Gaps = 4/114 (3%)
Query: 555 LQMEVKMLSSSKSMKELTEEQQNLQKELESLQNEHAQRMEEFYVEQKDLEKKLEQIMKQK 614
++ME K+L +K K LT + Q+ + + SLQN EE ++ + L+++ + K
Sbjct: 2713 VEMEQKLLMVTKENKGLTAQIQSFGRSMSSLQNSRDHANEELDELKRKYDASLKELAQLK 2772
Query: 615 CTCDSNLEKD---KEAEYAGQLAELRQRLDHAEADRQELQDELRQEREARQKLE 665
N E+D E ++ E L H E Q+L + Q +LE
Sbjct: 2773 EQGLLNRERDALLSETAFSMNSTE-ENSLSHLEKLNQQLLSKDEQLLHLSSQLE 2825
Score = 34.7 bits (78), Expect = 0.30
Identities = 53/241 (21%), Positives = 107/241 (44%), Gaps = 34/241 (14%)
Query: 406 DKVVAPNVSLTSAVSQSKELTK--TEASKSISRQSEKAHSSGKLQKTVSYPDVSLEEQEK 463
D+ + N SL+S+ K + TE + + ++ E SS K+ ++ + + E Q++
Sbjct: 1556 DRSLLENQSLSSSCESLKLALEGLTEDKEKLVKEIESLKSS-KIAESTEWQEKHKELQKE 1614
Query: 464 MD-LKTSRELCSRLDASISNNSTSKRKSESATCNLVRDINKVGIGLVAAASSPLLVKDVI 522
+ L S E S I + + R+ + +R A+ K +
Sbjct: 1615 YEILLQSYENVSNEAERIQHVVEAVRQEKQELYGKLRSTE---------ANKKETEKQLQ 1665
Query: 523 CEDDKGKIMEEVMRTYLK-QQEKLNLILQKKQQLQMEVK------------MLSSSKSMK 569
+ + + M+E MR + K +Q+K+ + ++ +L+ EV +LSS+ SMK
Sbjct: 1666 EAEQEMEEMKEKMRKFAKSKQQKILELEEENDRLRAEVHPAGDTAKECMETLLSSNASMK 1725
Query: 570 ELTE----EQQNLQKELESLQNEHAQRMEEFYVEQKDLEKKLEQIMKQKCTCDSNLEKDK 625
E E E + L K+ +SL +E EE +DL+ ++E + ++ ++ + D
Sbjct: 1726 EELERVKMEYETLSKKFQSLMSEKDSLSEEV----QDLKHQIEGNVSKQANLEATEKHDN 1781
Query: 626 E 626
+
Sbjct: 1782 Q 1782
Score = 34.3 bits (77), Expect = 0.39
Identities = 60/341 (17%), Positives = 142/341 (41%), Gaps = 55/341 (16%)
Query: 349 EEMKEKFSMRSGKRNQSKTDAPSGM----ELQSWYPVIKQEGDHVSQT--HSFLHPSYYL 402
E+++E + SG + +P+G ELQ + ++K+E + + + ++ L
Sbjct: 947 EQVEEDNEVSSGLKQNYDEMSPAGQISKEELQHEFDLLKKENEQRKRKLQAALINRKELL 1006
Query: 403 YMCDKVVAPNVSLTSAVSQSKELTKTEASKSISRQSEKAHS----SGKLQKTVSYPDVSL 458
++ +L + L++TE + + K +S + K Q+ Y ++
Sbjct: 1007 QRVSRLEEELANLKDESKKEIPLSETERGEVEEDKENKEYSEKCVTSKCQEIEIYLKQTI 1066
Query: 459 EEQEKMDLKTSRELCSRLDASISNNSTSKRKSESATCNLVRDINKVGIGLVAAASSPLLV 518
E+E ++L +L A + K+ +++ L N++ + + + ++
Sbjct: 1067 SEKEVELQHIRKDLEEKLAAEEQFQALVKQMNQT----LQDKTNQIDLLQAEISENQAII 1122
Query: 519 KDVICEDDKGKIMEEVMRTYLKQQEKLNLILQKKQQLQMEVKMLSSSKSMK-ELTEEQQN 577
+ +I + T + + L+ K+ + + SS+ K EL E+
Sbjct: 1123 QKLITSN-----------TDASDGDSVALV---KETVVISPPCTGSSEHWKPELEEKILA 1168
Query: 578 LQKELESLQNEHAQRMEEFYVEQKDLEKKLEQIMKQKCTCDSNLEKDKEAEYAGQLAELR 637
L+KE E LQ ++++E +K + KK + EK++ LR
Sbjct: 1169 LEKEKEQLQ----KKLQEALTSRKAILKKAQ-------------EKERH---------LR 1202
Query: 638 QRLDHAEADRQELQDELRQEREARQKLEMMIKELKLQILKS 678
+ L + D LQ++ ++ + + + +++L++Q+ +S
Sbjct: 1203 EELKQQKDDYNRLQEQFDEQSKENENIGDQLRQLQIQVRES 1243
Score = 31.6 bits (70), Expect = 2.5
Identities = 35/147 (23%), Positives = 65/147 (44%), Gaps = 15/147 (10%)
Query: 537 TYLKQQEKLNLILQKKQQLQMEVKMLSSSKSMKELTEEQQNLQKELESLQNEHAQRMEEF 596
T Q+K L +Q +Q ++E K + +KE E ++L++ +LQ E ++
Sbjct: 2545 TIKDSQQKQLLEVQLQQNKELENKYAKLEEKLKESEEANEDLRRSFNALQEE----KQDL 2600
Query: 597 YVEQKDLEKKLEQIMKQKCTCDSNLEKDKEAEYAGQL---AELRQRLDHAEADRQELQDE 653
E + L+ + Q+ +Q E+ Y QL E RL + Q+ E
Sbjct: 2601 SKEIESLKVSISQLTRQVTALQ---EEGTLGLYHAQLKVKEEEVHRLSALFSSSQKRIAE 2657
Query: 654 LRQE-----REARQKLEMMIKELKLQI 675
L +E +EA +K+ + +LK ++
Sbjct: 2658 LEEELVCVQKEAAKKVGEIEDKLKKEL 2684
Score = 30.4 bits (67), Expect = 5.7
Identities = 34/132 (25%), Positives = 59/132 (44%), Gaps = 12/132 (9%)
Query: 555 LQMEVKMLSSSKSMKELTEEQQNLQKELESLQNEHAQRMEEFYVEQKDLEKKLEQIMKQK 614
LQ + +KE+ E+ L+ ++ S +E ++ EE + Q EQI KQ
Sbjct: 1298 LQGGTSVAQIKAQLKEIEAEKVELELKVSSTTSELTKKSEEVFQLQ-------EQINKQG 1350
Query: 615 CTCDSNLEKDKEAEYAGQLAELRQRLDHAEADRQELQD--ELRQEREARQKLEMMIKELK 672
+S EAE + L+Q+L+ ++ L+ EL+ + + QKL + KE
Sbjct: 1351 LEIESLKTVSHEAEVHAE--SLQQKLESSQLQIAGLEHLRELQPKLDELQKL-ISKKEED 1407
Query: 673 LQILKSSKTAKE 684
+ L + KE
Sbjct: 1408 VSYLSGQLSEKE 1419
Score = 30.4 bits (67), Expect = 5.7
Identities = 25/142 (17%), Positives = 64/142 (45%), Gaps = 8/142 (5%)
Query: 533 EVMRTYLKQQEKLNLILQKKQQLQMEVKMLSSSKSMKELTEEQQNLQKELESLQNEHAQR 592
E+ R ++ ++KL ++ ++ + L +++ S +SM L + + +EL+ L+ ++
Sbjct: 2707 ELARDLVEMEQKLLMVTKENKGLTAQIQ--SFGRSMSSLQNSRDHANEELDELKRKYDAS 2764
Query: 593 MEEF--YVEQKDLEKKLEQIMKQKCTCDSNLEKDKEAEYAGQLAELRQRLDHAEADRQEL 650
++E EQ L ++ + ++ + ++ E++ L +L Q+L + L
Sbjct: 2765 LKELAQLKEQGLLNRERDALLSETAFSMNSTEENS----LSHLEKLNQQLLSKDEQLLHL 2820
Query: 651 QDELRQEREARQKLEMMIKELK 672
+L Q + L+
Sbjct: 2821 SSQLEDSYNQVQSFSKAMASLQ 2842
Score = 29.6 bits (65), Expect = 9.7
Identities = 78/372 (20%), Positives = 145/372 (38%), Gaps = 35/372 (9%)
Query: 332 NQKYLGTPEEKKLKII-LEEMKEKF-----SMRSGKRNQSKTDAPSGMELQSWYPVIKQE 385
NQ + E KL + L E KEK S++S K +S ELQ Y ++ Q
Sbjct: 1562 NQSLSSSCESLKLALEGLTEDKEKLVKEIESLKSSKIAESTEWQEKHKELQKEYEILLQS 1621
Query: 386 GDHVS-QTHSFLHPSYYLYMCDKVVAPNVSLTSAVSQSKELTKTEASKSISRQSEKAHSS 444
++VS + H + + + + T A + E EA + + EK
Sbjct: 1622 YENVSNEAERIQHVVEAVRQEKQELYGKLRSTEANKKETEKQLQEAEQEMEEMKEKMR-- 1679
Query: 445 GKLQKTVSYPDVSLEEQE---KMDLKTSRELCSR-LDASISNNSTSKRKSESATCNLVRD 500
K K+ + LEE+ + ++ + + ++ +S+N++ K + E
Sbjct: 1680 -KFAKSKQQKILELEEENDRLRAEVHPAGDTAKECMETLLSSNASMKEELERVKME-YET 1737
Query: 501 INKVGIGLVAAASSPLLVKDVICEDDKGKIMEEVMRTYLKQQEKLNLILQKKQQLQMEVK 560
++K L++ S L ++V +D K +I V ++ NL +K Q V
Sbjct: 1738 LSKKFQSLMSEKDS--LSEEV--QDLKHQIEGNV-------SKQANLEATEKHDNQTNVT 1786
Query: 561 MLSSSKSMKELTEEQQNLQKELESLQNEHA-------QRMEEFYVEQKDLEKKLEQIMKQ 613
++S+ TEEQ +L +E + + + ++ L+QI +
Sbjct: 1787 E-EGTQSIPGETEEQDSLSMSTRPTCSESVPSAKSANPAVSKDFSSHDEINNYLQQIDQL 1845
Query: 614 K-CTCDSNLEKDKEAEYAGQLAELRQRLDHAEADRQELQDELRQEREARQKLEMMIKELK 672
K EK K E++ L + L + + L++E L I+E
Sbjct: 1846 KERIAGLEEEKQKNKEFSQTLENEKNTLLSQISTKDGELKMLQEEVTKMNLLNQQIQEEL 1905
Query: 673 LQILKSSKTAKE 684
++ K +TA+E
Sbjct: 1906 SRVTKLKETAEE 1917
>gi|239745095 PREDICTED: hypothetical protein LOC645202 [Homo
sapiens]
Length = 570
Score = 53.5 bits (127), Expect = 6e-07
Identities = 56/221 (25%), Positives = 97/221 (43%), Gaps = 20/221 (9%)
Query: 466 LKTSRELCSRLDASISNNSTSKRKSESATCNLVRDINKVGIGLVAAASSPLLVKDVICED 525
L S + L+ ++S +T K+K++ L ++ + + + L ++ I +
Sbjct: 155 LHDSWKFAGELEQALSAVATQKKKADRYIEELTKERDALSLELY---------RNTITD- 204
Query: 526 DKGKIMEEVMRTYLKQQEKLNLILQKKQQLQMEVKMLSSSKSMKELTEEQQNLQKELESL 585
EE+ K QEKL L+ +K ++Q+ VK L +L QQ LQ E + L
Sbjct: 205 ------EELKEKNAKLQEKLQLVESEKSEIQLNVKELKRKLERAKLLLPQQQLQAEADHL 258
Query: 586 QNE--HAQRMEEFYVEQKDLEKKLEQIMKQKCTCDSNLEKDKEAEYAGQLAELRQRLDHA 643
E + VE+ +L +L Q ++K EK +E E Q E + R
Sbjct: 259 GKELQSVSAKLQAQVEENELWNRLNQQQEEKMWRQE--EKIQEREEKIQEQEEKIREQEE 316
Query: 644 EADRQELQDELRQEREARQKLEMMIKELKLQILKSSKTAKE 684
+ RQE ++E+ RQ+ M KE K++ L+ +E
Sbjct: 317 KMRRQEEMMWEKEEKMRRQEEMMWEKEEKIRELEEKMHEQE 357
Score = 47.4 bits (111), Expect = 4e-05
Identities = 34/168 (20%), Positives = 88/168 (52%), Gaps = 5/168 (2%)
Query: 519 KDVICEDDKGKIMEEVMRTYLKQQEKLNLILQKKQQLQMEVKMLSSSKSMKELTEEQQNL 578
++ I E ++ + EE +R K+QE+ + +++++++ + + + + M + EE+
Sbjct: 356 QEKIREQEEKRQEEEKIREQEKRQEQEAKMWRQEEKIREQEEKIREQEEMMQEQEEKMGE 415
Query: 579 QKELESLQNEHAQRMEEFYVEQKDLEKKLEQIMKQKCTCDSNLEKDKE--AEYAGQLAEL 636
Q+E Q E Q EE Q++ ++ E+ ++++ + + + +E E ++ E
Sbjct: 416 QEEKMWEQEEEMQEQEEKMRRQEEKIREQEKKIREQ---EEKIREQEEMMQEQEEKMGEQ 472
Query: 637 RQRLDHAEADRQELQDELRQEREARQKLEMMIKELKLQILKSSKTAKE 684
++ EA QE ++++R++ E ++ E I+E + +I + + +E
Sbjct: 473 EGKMCEQEAKMQEQEEKMRRQEEKIREQEKKIREQEEKIREQEEMMQE 520
Score = 41.6 bits (96), Expect = 0.002
Identities = 44/257 (17%), Positives = 123/257 (47%), Gaps = 15/257 (5%)
Query: 419 VSQSKELTKTEASKSISRQSEKAHSSGKLQKTVSYPDVSLEEQEKMDLKTS-RELCSRLD 477
+++ ++ E ++ E + KLQ+ + L E EK +++ + +EL +L+
Sbjct: 186 LTKERDALSLELYRNTITDEELKEKNAKLQEKLQ-----LVESEKSEIQLNVKELKRKLE 240
Query: 478 ASISNNSTSKRKSESATCNLVRDINKVGIGLVAAASSPLLVKDVICEDDKGKIMEEVMRT 537
+ +++ ++ +L +++ V L A L + + + E++ R
Sbjct: 241 RA--KLLLPQQQLQAEADHLGKELQSVSAKLQAQVEENELWNRLNQQQE-----EKMWRQ 293
Query: 538 YLKQQEKLNLILQKKQQLQMEVKMLSSSKSMKELTEEQQNLQKELESLQNEHAQRMEEFY 597
K QE+ I +++++++ + + + + M EE+ Q+E+ + E + +EE
Sbjct: 294 EEKIQEREEKIQEQEEKIREQEEKMRRQEEMMWEKEEKMRRQEEMMWEKEEKIRELEEKM 353
Query: 598 VEQKDLEKKLEQIMKQKCTCDSNLEKDKEAEYAGQLAELRQRLDHAEADRQELQDELRQE 657
EQ+ + ++ E+ +++ + +++EA+ Q ++R++ + + +Q++ +E
Sbjct: 354 HEQEKIREQEEKRQEEEKIREQEKRQEQEAKMWRQEEKIREQEEKIREQEEMMQEQ--EE 411
Query: 658 REARQKLEMMIKELKLQ 674
+ Q+ +M +E ++Q
Sbjct: 412 KMGEQEEKMWEQEEEMQ 428
Score = 41.2 bits (95), Expect = 0.003
Identities = 34/152 (22%), Positives = 79/152 (51%), Gaps = 17/152 (11%)
Query: 524 EDDKGKIMEEVMRTYLKQQEKLNLILQKKQQLQMEVKMLSSSKSMKELTEEQQNLQKELE 583
++++ + EE MR +Q+EK+ Q+K+ + E K+ + +E+ +EQ+ E E
Sbjct: 423 QEEEMQEQEEKMR---RQEEKIRE--QEKKIREQEEKI----REQEEMMQEQEEKMGEQE 473
Query: 584 SLQNEHAQRMEEFYVEQKDLEKKLEQIMKQKCTCDSNLEKDKEAEYAGQ-----LAELRQ 638
E +M+E +++ + ++ E+I +Q+ EK +E E Q + E +
Sbjct: 474 GKMCEQEAKMQE---QEEKMRRQEEKIREQEKKIREQEEKIREQEEMMQEQEEKMWEQEE 530
Query: 639 RLDHAEADRQELQDELRQEREARQKLEMMIKE 670
++ E QE ++++R++ E ++ E+ +++
Sbjct: 531 KMCEQEEKMQEQEEKMRRQEEKMREQEVRLRQ 562
Score = 39.3 bits (90), Expect = 0.012
Identities = 31/149 (20%), Positives = 77/149 (51%), Gaps = 14/149 (9%)
Query: 524 EDDKGKIMEEVMRTYLKQQEKLNLILQKKQQLQMEVKMLSSSKSMKELTEEQQNLQKELE 583
+++K + EE+M +++EK+ L++K Q +++ + +E EQ+ Q++
Sbjct: 328 KEEKMRRQEEMM---WEKEEKIRE-LEEKMHEQEKIREQEEKRQEEEKIREQEKRQEQEA 383
Query: 584 SL--QNEHAQRMEEFYVEQKDLEKKLEQIMKQKCTCDSNLEKDKEAEYAGQLAELRQRLD 641
+ Q E + EE EQ+++ ++ E+ M + +++K E ++ E +++
Sbjct: 384 KMWRQEEKIREQEEKIREQEEMMQEQEEKMGE--------QEEKMWEQEEEMQEQEEKMR 435
Query: 642 HAEADRQELQDELRQEREARQKLEMMIKE 670
E +E + ++R++ E ++ E M++E
Sbjct: 436 RQEEKIREQEKKIREQEEKIREQEEMMQE 464
Score = 38.9 bits (89), Expect = 0.016
Identities = 41/164 (25%), Positives = 79/164 (48%), Gaps = 7/164 (4%)
Query: 525 DDKGKIMEEVMRTYLKQQEKLNLILQKKQQLQMEVKMLSSSKSMKELTEEQQNLQKELES 584
D GK ++ V Q E+ L + QQ E KM + ++E E+ Q ++++
Sbjct: 256 DHLGKELQSVSAKLQAQVEENELWNRLNQQ--QEEKMWRQEEKIQEREEKIQEQEEKIRE 313
Query: 585 LQNEHAQRMEEFYVEQKDLEKKLEQIMKQKCTCDSNLE-KDKEAEYAGQLAELRQRLD-- 641
Q E +R EE E+++ ++ E++M +K LE K E E + E RQ +
Sbjct: 314 -QEEKMRRQEEMMWEKEEKMRRQEEMMWEKEEKIRELEEKMHEQEKIREQEEKRQEEEKI 372
Query: 642 HAEADRQELQDEL-RQEREARQKLEMMIKELKLQILKSSKTAKE 684
+ RQE + ++ RQE + R++ E + ++ ++ + K ++
Sbjct: 373 REQEKRQEQEAKMWRQEEKIREQEEKIREQEEMMQEQEEKMGEQ 416
Score = 38.9 bits (89), Expect = 0.016
Identities = 34/163 (20%), Positives = 81/163 (49%), Gaps = 9/163 (5%)
Query: 525 DDKGKIMEEVMRTYLKQQEKLNLILQKKQQLQMEVKMLSSSKSMKELTEEQQNLQKELES 584
++K + EE +R +Q+EK+ Q++ + E KM + M E E+ + L++++
Sbjct: 301 EEKIQEQEEKIR---EQEEKMRR--QEEMMWEKEEKMRRQEEMMWEKEEKIRELEEKMHE 355
Query: 585 LQNEHAQRMEEFYVEQKDLEKKLEQIMKQKCTCDSNLEKDKEAEYAGQ---LAELRQRLD 641
Q + ++ E+ E+K E++ Q + K +++E + Q + E +++
Sbjct: 356 -QEKIREQEEKRQEEEKIREQEKRQEQEAKMWRQEEKIREQEEKIREQEEMMQEQEEKMG 414
Query: 642 HAEADRQELQDELRQEREARQKLEMMIKELKLQILKSSKTAKE 684
E E ++E++++ E ++ E I+E + +I + + +E
Sbjct: 415 EQEEKMWEQEEEMQEQEEKMRRQEEKIREQEKKIREQEEKIRE 457
Score = 35.0 bits (79), Expect = 0.23
Identities = 31/160 (19%), Positives = 75/160 (46%), Gaps = 30/160 (18%)
Query: 532 EEVMRTYLKQQ-EKLNLILQKKQQLQMEVKMLSSSKSMKELTEEQQNLQKELESLQNEHA 590
+E +R L+ Q + + ++ +K +LQM + Q+ K+LE +
Sbjct: 106 QEALRRELEAQVQTIRILTCQKTELQMALYY-------------SQHAVKQLEGEARDLI 152
Query: 591 QRMEEFYVEQKDLEKKLEQIMKQKCTCDSNLE---KDKEA-------------EYAGQLA 634
R+ + + +LE+ L + QK D +E K+++A E + A
Sbjct: 153 SRLHDSWKFAGELEQALSAVATQKKKADRYIEELTKERDALSLELYRNTITDEELKEKNA 212
Query: 635 ELRQRLDHAEADRQELQDELRQEREARQKLEMMIKELKLQ 674
+L+++L E+++ E+Q +++ + ++ ++++ + +LQ
Sbjct: 213 KLQEKLQLVESEKSEIQLNVKELKRKLERAKLLLPQQQLQ 252
Score = 30.0 bits (66), Expect = 7.4
Identities = 28/94 (29%), Positives = 49/94 (52%), Gaps = 7/94 (7%)
Query: 522 ICEDD-KGKIMEEVMRTYLKQQEKLNLILQKKQQLQMEVKMLSSSKSMKELTEEQQNLQK 580
+CE + K + EE MR +Q+EK+ Q+K+ + E K+ + M+E EE+ Q+
Sbjct: 476 MCEQEAKMQEQEEKMR---RQEEKIRE--QEKKIREQEEKIREQEEMMQE-QEEKMWEQE 529
Query: 581 ELESLQNEHAQRMEEFYVEQKDLEKKLEQIMKQK 614
E Q E Q EE Q++ ++ E ++Q+
Sbjct: 530 EKMCEQEEKMQEQEEKMRRQEEKMREQEVRLRQQ 563
>gi|71361682 nuclear mitotic apparatus protein 1 [Homo sapiens]
Length = 2115
Score = 53.5 bits (127), Expect = 6e-07
Identities = 62/261 (23%), Positives = 113/261 (43%), Gaps = 31/261 (11%)
Query: 424 ELTKTEASKSISR--QSEKAHSSGKLQKTVSYPDVSLEEQEKMDLKTSRELCSRLDASIS 481
EL K +S S + A G + +T + L++Q L R L+ ++
Sbjct: 183 ELQKVASSSSGNNFLSGSPASPMGDILQTPQFQMRRLKKQ----LADERSNRDELELELA 238
Query: 482 NNSTSKRKSESATCNLVRDINKVGIGLVAAASSPLLVKDVICEDDKGKIMEEVMRTYLKQ 541
N + ++ + + I+++ + A+SPL K++ DK + + + LKQ
Sbjct: 239 ENRKLLTEKDAQIAMMQQRIDRLALLNEKQAASPLEPKELEELRDKNESLTMRLHETLKQ 298
Query: 542 QEKLNLILQKKQQLQMEVKMLSS-----SKSMKELTEEQQNLQKELESLQNEHAQRMEEF 596
+ L +K Q+ ++ LS S ++E Q LQ L L EH++ +E+
Sbjct: 299 CQDLKT---EKSQMDRKINQLSEENGDLSFKLREFASHLQQLQDALNELTEEHSKATQEW 355
Query: 597 YVEQKDLEKKLEQIMKQKCTCDSNLEKDKEAEYAGQLAELRQRLDHAEADRQELQDELRQ 656
+Q LEK+L ++ D ++K G+L++L + L +LQD Q
Sbjct: 356 LEKQAQLEKELSAALQ-----DKKCLEEKNEILQGKLSQLEEHL-------SQLQDNPPQ 403
Query: 657 EREARQKLEMMIKELKLQILK 677
E K E++ L+L+ LK
Sbjct: 404 E-----KGEVLGDVLQLETLK 419
Score = 52.8 bits (125), Expect = 1e-06
Identities = 58/241 (24%), Positives = 113/241 (46%), Gaps = 25/241 (10%)
Query: 460 EQEKMDLKTSRELCSRLDASISNNSTSKRKSESATCNLVRDINKVGIGLVAAASSPLLVK 519
E+EK L + L + L +SISN S +K + E A+ + VA+ +S L
Sbjct: 458 EEEKQQLSS---LITDLQSSISNLSQAKEELEQASQAHGARLT----AQVASLTSELTTL 510
Query: 520 DVICEDDKGKIMEEVMRTYLKQQEKLNLILQKKQQ---LQMEVKMLSSSKSMKELTEEQQ 576
+ + ++ + KQ + + Q++Q L+ +V+ LSSS KE ++ +
Sbjct: 511 NATIQQQDQELAGLKQQAKEKQAQLAQTLQQQEQASQGLRHQVEQLSSSLKQKE--QQLK 568
Query: 577 NLQKELESLQNEHAQRM------EEFYVEQKDLE-KKLEQIMKQKCT----CDSNLEKDK 625
+ ++ E+ + +HAQ++ E + ++D K+LE + K+K L+
Sbjct: 569 EVAEKQEATRQDHAQQLATAAEEREASLRERDAALKQLEALEKEKAAKLEILQQQLQVAN 628
Query: 626 EAEYAGQLAELRQRLDHAEADR--QELQDELRQEREARQKLEMMIKELKLQILKSSKTAK 683
EA + Q + + + + AE R +ELQ + R+ + + + + EL+LQ+ + A
Sbjct: 629 EARDSAQTSVTQAQREKAELSRKVEELQACVETARQEQHEAQAQVAELELQLRSEQQKAT 688
Query: 684 E 684
E
Sbjct: 689 E 689
Score = 40.0 bits (92), Expect = 0.007
Identities = 49/258 (18%), Positives = 114/258 (44%), Gaps = 22/258 (8%)
Query: 419 VSQSKELTKTEASKSISRQSEKAHSSGKLQKTVSYPDVSLEEQEKMDLKTSRELCSRLDA 478
V++ +E T+ + ++ ++ +E+ +S + + +LE+++ L+ ++ +
Sbjct: 570 VAEKQEATRQDHAQQLATAAEEREASLRERDAALKQLEALEKEKAAKLEILQQQLQVANE 629
Query: 479 SISNNSTSKRKSESATCNLVRDINKVGIGLVAAASSPLLVKDVICEDDKGKIMEEVMRTY 538
+ + TS +++ L R + ++ + A + + E +E +R+
Sbjct: 630 ARDSAQTSVTQAQREKAELSRKVEELQACVETARQEQHEAQAQVAE------LELQLRSE 683
Query: 539 LKQQEKLNLILQKKQQLQMEVKMLSSSKSMKE--LTEEQQNLQKELESLQNEHAQRMEEF 596
++ + + Q+K QLQ +++ L S + + L EE++ LE Q ++ E
Sbjct: 684 QQKATEKERVAQEKDQLQEQLQALKESLKVTKGSLEEEKRRAADALEEQQRCISELKAET 743
Query: 597 --YVEQKDLEKK-LEQIMKQKCTCDSNLEKDKEAEYAGQLAELRQRLDHAEADRQELQDE 653
VEQ E+K LE+ + ++ L++ EA A E R+EL +
Sbjct: 744 RSLVEQHKRERKELEEERAGRKGLEARLQQLGEAHQA-----------ETEVLRRELAEA 792
Query: 654 LRQEREARQKLEMMIKEL 671
+ + A + E ++KE+
Sbjct: 793 MAAQHTAESECEQLVKEV 810
Score = 39.7 bits (91), Expect = 0.009
Identities = 43/175 (24%), Positives = 78/175 (44%), Gaps = 37/175 (21%)
Query: 524 EDDKGKIMEEVMRTYLKQQEKLNLILQKKQQLQMEVKMLSSSKSMKELTEE--------- 574
E K K++EE R Q+E+ L Q +Q +EV +K ++EL+++
Sbjct: 1513 EGAKVKVLEERQRF---QEERQKLTAQVEQ---LEVFQREQTKQVEELSKKLADSDQASK 1566
Query: 575 -QQNLQKELESLQNEHAQRMEEFYVEQKDLEKKLEQIMKQKCTCDSNLEKDKEAE-YAGQ 632
QQ K +++ E Q + + +L+ +L Q K++ AE Y Q
Sbjct: 1567 VQQQKLKAVQAQGGESQQEAQRLQAQLNELQAQLSQ-------------KEQAAEHYKLQ 1613
Query: 633 LAELRQRLDHAEADRQELQDELR-------QEREARQKLEMMIKELKLQILKSSK 680
+ + + D + QELQ++LR + +E R + E + EL+ LK+ +
Sbjct: 1614 MEKAKTHYDAKKQQNQELQEQLRSLEQLQKENKELRAEAERLGHELQQAGLKTKE 1668
Score = 38.1 bits (87), Expect = 0.027
Identities = 46/177 (25%), Positives = 70/177 (39%), Gaps = 39/177 (22%)
Query: 542 QEKLNLILQKKQQLQMEVKML-----SSSKSMKELTEEQQNLQKELESLQNEHAQ----- 591
QE L L +K+ E+ L + K ++EL + + L+++L + EHA
Sbjct: 1049 QEALAHALTEKEGKDQELAKLRGLEAAQIKELEELRQTVKQLKEQLAKKEKEHASGSGAQ 1108
Query: 592 ------------RMEEFYVEQKDLEKKLEQIMKQKCTCDSNLEKDKEAEYA--------- 630
++E E LE +Q KQ+ DS LE+ EAE A
Sbjct: 1109 SEAAGRTEPTGPKLEALRAEVSKLE---QQCQKQQEQADS-LERSLEAERASRAERDSAL 1164
Query: 631 ----GQLAELRQRLDHAEADRQELQDELRQEREARQKLEMMIKELKLQILKSSKTAK 683
GQL E Q L H+++ Q EL R Q E K Q+ + + A+
Sbjct: 1165 ETLQGQLEEKAQELGHSQSALASAQRELAAFRTKVQDHSKAEDEWKAQVARGRQEAE 1221
Score = 36.2 bits (82), Expect = 0.10
Identities = 54/307 (17%), Positives = 132/307 (42%), Gaps = 32/307 (10%)
Query: 383 KQEGDHVSQTHSFLHPSYYLYMCDKVVAPNVSLT------SAVSQSKELTKTEASKSISR 436
K+E + SQ H + + ++ N ++ + + Q + + + ++++ +
Sbjct: 482 KEELEQASQAHGARLTAQVASLTSELTTLNATIQQQDQELAGLKQQAKEKQAQLAQTLQQ 541
Query: 437 QSEKA----HSSGKLQKTVSYPDVSLEEQEKMDLKTSRELCSRLDASISNNSTSKRKSES 492
Q + + H +L ++ + L+E + T ++ +L + S R+ ++
Sbjct: 542 QEQASQGLRHQVEQLSSSLKQKEQQLKEVAEKQEATRQDHAQQLATAAEEREASLRERDA 601
Query: 493 ATCNLVRDINKVGIGLVAAASSPLLVKDV-ICEDDKGKIMEEVMRTYLKQQEKLNLILQK 551
A L + AA +L + + + + + V + Q+EK L +K
Sbjct: 602 ALKQLE------ALEKEKAAKLEILQQQLQVANEARDSAQTSVTQA---QREKAELS-RK 651
Query: 552 KQQLQMEVKMLSSSKSMKELTEEQQNLQKELESLQNEHAQRMEEFYVEQKDLEKKLEQIM 611
++LQ V+ ++ + E + L+ +L S Q + ++ E E+ L+++L+ +
Sbjct: 652 VEELQACVE--TARQEQHEAQAQVAELELQLRSEQQKATEK-ERVAQEKDQLQEQLQALK 708
Query: 612 KQKCTCDSNLEKDKEAEYAGQLAELRQRLDHAEADRQELQDE-------LRQEREARQKL 664
+ +LE++K A L E ++ + +A+ + L ++ L +ER R+ L
Sbjct: 709 ESLKVTKGSLEEEKRRA-ADALEEQQRCISELKAETRSLVEQHKRERKELEEERAGRKGL 767
Query: 665 EMMIKEL 671
E +++L
Sbjct: 768 EARLQQL 774
Score = 34.3 bits (77), Expect = 0.39
Identities = 48/270 (17%), Positives = 116/270 (42%), Gaps = 19/270 (7%)
Query: 415 LTSAVSQSKEL-TKTEASKSISRQSEKAHSSGKLQKTVSYPDVSLEEQEKMDLKTSRELC 473
LTS +++EL + +A + Q E+A S+ +L+ T + VS +L ++ LC
Sbjct: 1315 LTSQAERAEELGQELKAWQEKFFQKEQALSTLQLEHTSTQALVS-------ELLPAKHLC 1367
Query: 474 SRLDASISNNSTSKRKSESATCNLVRDINKVGIGLVAAASSPLLVKDVICEDDKGKIMEE 533
+L A + R+ + + + + ++ + E ++ ++
Sbjct: 1368 QQLQAEQAAAEKRHREELEQSKQAAGGLRAELLRAQRELGELIPLRQKVAEQER--TAQQ 1425
Query: 534 VMRTYLKQQEKLNLILQKKQQLQMEVKMLSSSKSMKELTEEQQNLQKELESLQNEHAQRM 593
+ E+L+++ + L E + L ++ +Q L+ EL+ + ++ Q
Sbjct: 1426 LRAEKASYAEQLSMLKKAHGLLAEENRGLGERANLG-----RQFLEVELDQAREKYVQ-- 1478
Query: 594 EEFYVEQKDLEKKLEQIMKQKCTCDSNLEKDKEAEYAGQLAELRQRLDHAEADRQELQDE 653
E + D E +L ++ ++ + LE A+Y G ++ + + +RQ+L +
Sbjct: 1479 -ELAAVRADAETRLAEVQREAQSTARELEV-MTAKYEGAKVKVLEERQRFQEERQKLTAQ 1536
Query: 654 LRQEREARQKLEMMIKELKLQILKSSKTAK 683
+ Q +++ ++EL ++ S + +K
Sbjct: 1537 VEQLEVFQREQTKQVEELSKKLADSDQASK 1566
Score = 31.2 bits (69), Expect = 3.3
Identities = 30/139 (21%), Positives = 57/139 (41%), Gaps = 7/139 (5%)
Query: 521 VICEDDKGKIMEEVMRTYLKQQEKLNLILQKKQQLQMEVKMLSSSKSMKELTEEQQNLQK 580
V+ E +K + +EE +R L Q E + + + + +S++E E+Q+ +
Sbjct: 1255 VMAESEKSQKLEERLR--LLQAETAS---NSARAAERSSALREEVQSLREEAEKQRVASE 1309
Query: 581 ELESLQNEHAQRMEEFYVEQKDLEKKLEQIMKQKCTCDSNLEKDKEAEYAGQLAELRQRL 640
L A+R EE E K ++K Q K++ LE +L +
Sbjct: 1310 NLRQELTSQAERAEELGQELKAWQEKFFQ--KEQALSTLQLEHTSTQALVSELLPAKHLC 1367
Query: 641 DHAEADRQELQDELRQERE 659
+A++ + R+E E
Sbjct: 1368 QQLQAEQAAAEKRHREELE 1386
>gi|222418637 golgi autoantigen, golgin subfamily a-like [Homo
sapiens]
Length = 750
Score = 53.1 bits (126), Expect = 8e-07
Identities = 49/222 (22%), Positives = 102/222 (45%), Gaps = 23/222 (10%)
Query: 466 LKTSRELCSRLDASISNNSTSKRKSESATCNLVRDINKVGIGLVAAASSPLLVKDVICED 525
L S + L+ ++S +T K+K++ L ++ + + + L ++ I +
Sbjct: 167 LHDSWKFAGELEQALSAVATQKKKADRYIEELTKERDALSLELY---------RNTITD- 216
Query: 526 DKGKIMEEVMRTYLKQQEKLNLILQKKQQLQMEVKMLSSSKSMKELTEEQQNLQKELESL 585
EE+ K QEKL L+ +K ++Q+ VK L +L QQ LQ E + L
Sbjct: 217 ------EELKEKNAKLQEKLQLVESEKSEIQLNVKELKRKLERAKLLLPQQQLQAEADHL 270
Query: 586 QNE--HAQRMEEFYVEQKDLEKKLEQIMKQKCTCDSNLEKDKEAEYAGQLAELRQRLDHA 643
E + VE+ +L +L Q ++K +++K E+ ++ E +++
Sbjct: 271 GKELQSVSAKLQAQVEENELWNRLNQQQEEKMW----RQEEKIQEWEEKIQEQEEKIREQ 326
Query: 644 EADRQELQDELRQEREAR-QKLEMMIKELKLQILKSSKTAKE 684
E +E ++++R++ E +K E M ++ ++ K K ++
Sbjct: 327 EEKIREQEEKMRRQEEMMWEKEEKMRRQEEMMWEKEEKMRRQ 368
Score = 42.4 bits (98), Expect = 0.001
Identities = 51/267 (19%), Positives = 128/267 (47%), Gaps = 18/267 (6%)
Query: 419 VSQSKELTKTEASKSISRQSEKAHSSGKLQKTVSYPDVSLEEQEKMDLKTS-RELCSRLD 477
+++ ++ E ++ E + KLQ+ + L E EK +++ + +EL +L+
Sbjct: 198 LTKERDALSLELYRNTITDEELKEKNAKLQEKLQ-----LVESEKSEIQLNVKELKRKLE 252
Query: 478 ASISNNSTSKRKSESATCNLVRDINKVGIGLVAAASSPLLVKDVICEDDKG--KIMEEVM 535
+ +++ ++ +L +++ V L A L + + ++ + E++
Sbjct: 253 RA--KLLLPQQQLQAEADHLGKELQSVSAKLQAQVEENELWNRLNQQQEEKMWRQEEKIQ 310
Query: 536 RTYLKQQEKLNLILQKKQQLQMEVKMLSSSKSMKELTEEQQNLQKELESLQNEHAQRMEE 595
K QE+ I +++++++ + + + + M EE+ Q+E+ + E +R EE
Sbjct: 311 EWEEKIQEQEEKIREQEEKIREQEEKMRRQEEMMWEKEEKMRRQEEMMWEKEEKMRRQEE 370
Query: 596 FYVEQKDLEKKLEQIMKQKCTCDSNLEKDKE-AEYAGQLAELRQRLDHAEADRQELQDEL 654
E+++ ++ E++M +K EK +E E + ++R++ + + + + + E
Sbjct: 371 MMWEKEEKMRRQEEMMWEK------EEKIRELEEKMHEQEKIREQEEKRQEEEKIREQEK 424
Query: 655 RQEREARQ-KLEMMIKELKLQILKSSK 680
RQE+EA+ + E I+E + +I + K
Sbjct: 425 RQEQEAKMWRQEEKIREQEEKIREQEK 451
Score = 42.0 bits (97), Expect = 0.002
Identities = 36/162 (22%), Positives = 82/162 (50%), Gaps = 5/162 (3%)
Query: 524 EDDKGKIMEEVMRTYLKQQEKLNLILQKKQQLQMEVKMLSSSKSMKELTEEQQNLQKELE 583
+++K + EE+ R K E+ + ++K+Q Q E KM + ++E E+ ++++
Sbjct: 536 QEEKIREQEEMWREEEKMHEQEKIWEEEKRQEQ-EDKMWRQEEKIREQEEKVWRQEEKIR 594
Query: 584 SLQNEHAQRMEEFYVEQKDLEKKLEQIMKQKCTCDSNLEKDKEAEYAGQLAELRQRLDHA 643
+ + ++ E+ + +++ + ++ E+I +Q+ EK +E E Q E +++
Sbjct: 595 EQEEKRQEQEEKMWKQEEKIREQEEKIQEQEEKIREQEEKIREQEEMTQ--EQEEKMGEQ 652
Query: 644 EADRQELQDELRQEREARQ-KLEMMIKELKLQILKSSKTAKE 684
E E Q+E QE+E + E I+E + +I + + +E
Sbjct: 653 EEKMCE-QEEKMQEQEETMWRQEEKIREQEKKIREQEEKIRE 693
Score = 41.6 bits (96), Expect = 0.002
Identities = 51/261 (19%), Positives = 116/261 (44%), Gaps = 32/261 (12%)
Query: 429 EASKSISRQSEKAHSSGKL--QKTVSYPDVSLEEQEKMDLKTSRELCSRLDASISNNSTS 486
E + I EK H K+ Q+ + + EQEK + ++ R + I
Sbjct: 388 EKEEKIRELEEKMHEQEKIREQEEKRQEEEKIREQEKRQEQEAKMW--RQEEKIREQEEK 445
Query: 487 KRKSESATCNLVRDINKVGIGLVAAASSPLLVKDVICEDDKGKIMEEVMRTYLKQQEKLN 546
R+ E I++ ++ I E++K + EE+ R K E+
Sbjct: 446 IREQEKKMWRQEEKIHE---------------QEKIREEEKRQEQEEMWRQEEKIHEQEE 490
Query: 547 LILQKKQQLQMEVKMLSSSKSM----KELTEEQQNLQKELESL--QNEHAQRMEEFYVEQ 600
+ QK++ + E K+ + + +++ E+++ ++++ E + Q E + EE + E+
Sbjct: 491 IWRQKEKMHEQEEKIRKQEEKVWRQEEKIREQEEKIREQEEKMWRQEEKIREQEEMWREE 550
Query: 601 KDL---EKKLEQIMKQKCTCDSNLEKDKEAEYAGQLAELRQRLDHAEADRQELQDEL-RQ 656
+ + EK E+ +Q+ +++K E ++ +++ E RQE ++++ +Q
Sbjct: 551 EKMHEQEKIWEEEKRQEQEDKMWRQEEKIREQEEKVWRQEEKIREQEEKRQEQEEKMWKQ 610
Query: 657 E---REARQKLEMMIKELKLQ 674
E RE +K++ ++++ Q
Sbjct: 611 EEKIREQEEKIQEQEEKIREQ 631
Score = 40.8 bits (94), Expect = 0.004
Identities = 41/150 (27%), Positives = 77/150 (51%), Gaps = 8/150 (5%)
Query: 524 EDDKGKIMEEVMRTYLKQQEKLNLILQKKQQLQMEVKMLSSSKSMKELTEEQQNLQKELE 583
+++K + EE +R +Q+EK+ Q++ + E KM + M E EE+ Q+E+
Sbjct: 319 QEEKIREQEEKIR---EQEEKMRR--QEEMMWEKEEKMRRQEEMMWE-KEEKMRRQEEMM 372
Query: 584 SLQNEHAQRMEEFYVEQKDLEKKLEQIMKQKCTCDSNLEKDKEAEYAGQLAELRQRLDHA 643
+ E +R EE E+++ ++LE+ M ++ EK +E E + E RQ A
Sbjct: 373 WEKEEKMRRQEEMMWEKEEKIRELEEKMHEQEKIREQEEKRQEEEKIRE-QEKRQE-QEA 430
Query: 644 EADRQELQDELRQEREARQKLEMMIKELKL 673
+ RQE + ++E+ Q+ +M +E K+
Sbjct: 431 KMWRQEEKIREQEEKIREQEKKMWRQEEKI 460
Score = 39.7 bits (91), Expect = 0.009
Identities = 30/153 (19%), Positives = 79/153 (51%), Gaps = 12/153 (7%)
Query: 524 EDDKGKIMEEVMRTYLKQQEKLN----LILQKKQQLQMEVKMLSSSKSMKELTEEQQNLQ 579
+++K + EE M KQ+EK+ I +++++++ + + + + M + EE+ Q
Sbjct: 596 QEEKRQEQEEKM---WKQEEKIREQEEKIQEQEEKIREQEEKIREQEEMTQEQEEKMGEQ 652
Query: 580 KELESLQNEHAQRMEEFYVEQKDLEKKLEQIMKQKCTCDSNLEKDKE--AEYAGQLAELR 637
+E Q E Q EE Q++ ++ E+ ++++ + + + +E E ++ E
Sbjct: 653 EEKMCEQEEKMQEQEETMWRQEEKIREQEKKIREQ---EEKIREQEEMMQEQEEKMWEQE 709
Query: 638 QRLDHAEADRQELQDELRQEREARQKLEMMIKE 670
+++ E QE ++++R++ E + E+ +++
Sbjct: 710 EKMCEQEEKMQEQEEKMRRQEEKMWEQEVRLRQ 742
Score = 36.2 bits (82), Expect = 0.10
Identities = 34/161 (21%), Positives = 78/161 (48%), Gaps = 20/161 (12%)
Query: 524 EDDKGKIMEEVMRTYLKQQEKLNLILQKKQQLQMEVKMLSSSKSMKELTEEQQNLQKELE 583
+++K + EE+M +++EK+ Q++ + E KM + M E EE+ Q+E+
Sbjct: 333 QEEKMRRQEEMM---WEKEEKMRR--QEEMMWEKEEKMRRQEEMMWE-KEEKMRRQEEMM 386
Query: 584 SLQNEHAQRMEEFYVEQKDLEKKLEQIMKQKCTCDSNLEKDKEAEYAGQLAELRQRLDHA 643
+ E + +EE EQ+ + ++ E+ +++ + +++EA+ Q ++R++ +
Sbjct: 387 WEKEEKIRELEEKMHEQEKIREQEEKRQEEEKIREQEKRQEQEAKMWRQEEKIREQEEKI 446
Query: 644 EADRQEL--------------QDELRQEREARQKLEMMIKE 670
+++ ++E RQE+E + E I E
Sbjct: 447 REQEKKMWRQEEKIHEQEKIREEEKRQEQEEMWRQEEKIHE 487
Score = 35.8 bits (81), Expect = 0.13
Identities = 27/145 (18%), Positives = 72/145 (49%), Gaps = 10/145 (6%)
Query: 532 EEVMRTYLKQQEKLNLILQKKQQLQMEVKMLSSSKSMKELTEEQQNLQKELESLQNEHAQ 591
E++ K+QE+ + +++++++ + + + + EE+ Q+E+ Q E
Sbjct: 591 EKIREQEEKRQEQEEKMWKQEEKIREQEEKIQEQEEKIREQEEKIREQEEMTQEQEEKMG 650
Query: 592 RMEEFYVEQKDLEKKLEQIMKQKCTCDSNLEKDKEAEYAGQLAELRQRLDHAEADRQELQ 651
EE EQ++ ++ E+ M + +++K E ++ E +++ E QE +
Sbjct: 651 EQEEKMCEQEEKMQEQEETMWR--------QEEKIREQEKKIREQEEKIREQEEMMQEQE 702
Query: 652 DEL--RQEREARQKLEMMIKELKLQ 674
+++ ++E+ Q+ +M +E K++
Sbjct: 703 EKMWEQEEKMCEQEEKMQEQEEKMR 727
Score = 34.3 bits (77), Expect = 0.39
Identities = 31/160 (19%), Positives = 74/160 (46%), Gaps = 30/160 (18%)
Query: 532 EEVMRTYLKQQ-EKLNLILQKKQQLQMEVKMLSSSKSMKELTEEQQNLQKELESLQNEHA 590
+E +R L+ Q + ++ +K +LQM + Q+ K+LE +
Sbjct: 118 QEALRRELEAQVHTIRILTCQKTELQMALYY-------------SQHAVKQLEGEARDLI 164
Query: 591 QRMEEFYVEQKDLEKKLEQIMKQKCTCDSNLE---KDKEA-------------EYAGQLA 634
R+ + + +LE+ L + QK D +E K+++A E + A
Sbjct: 165 SRLHDSWKFAGELEQALSAVATQKKKADRYIEELTKERDALSLELYRNTITDEELKEKNA 224
Query: 635 ELRQRLDHAEADRQELQDELRQEREARQKLEMMIKELKLQ 674
+L+++L E+++ E+Q +++ + ++ ++++ + +LQ
Sbjct: 225 KLQEKLQLVESEKSEIQLNVKELKRKLERAKLLLPQQQLQ 264
Score = 31.6 bits (70), Expect = 2.5
Identities = 23/99 (23%), Positives = 52/99 (52%), Gaps = 6/99 (6%)
Query: 519 KDVICEDDKGKIMEEVMRTYLKQQEKLN----LILQKKQQLQMEVKMLSSSKSMKELTEE 574
++ +CE ++ M+E T +Q+EK+ I +++++++ + +M+ + EE
Sbjct: 653 EEKMCEQEEK--MQEQEETMWRQEEKIREQEKKIREQEEKIREQEEMMQEQEEKMWEQEE 710
Query: 575 QQNLQKELESLQNEHAQRMEEFYVEQKDLEKKLEQIMKQ 613
+ Q+E Q E +R EE EQ+ ++ E+ M++
Sbjct: 711 KMCEQEEKMQEQEEKMRRQEEKMWEQEVRLRQQEEKMQE 749
>gi|22538387 A-kinase anchor protein 9 isoform 2 [Homo sapiens]
Length = 3907
Score = 53.1 bits (126), Expect = 8e-07
Identities = 67/324 (20%), Positives = 142/324 (43%), Gaps = 43/324 (13%)
Query: 396 LHPSYYLYMCDKVVAPNVSLTSAVSQSKELTKTEASKSISRQSEKAHSSGKLQK------ 449
L Y + ++V VS++ A +Q EL++ K + S++AH+ + ++
Sbjct: 1432 LEKQYQEQLEEEVAKVIVSMSIAFAQQTELSRISGGKENTASSKQAHAVCQQEQHYFNEM 1491
Query: 450 TVSYPDVSLEEQEKMDLK-------TSRELCSRLDASISNNSTSKRKSESATCNLVRDIN 502
+S + + E +D+K S+EL + +NS ES C L
Sbjct: 1492 KLSQDQIGFQTFETVDVKFKEEFKPLSKELGEHGKEILLSNSDPHDIPESKDCVLTISEE 1551
Query: 503 KVGIGLVAAASSPLLVKDVICEDDKGKIMEEVMRTYLKQQEKLNL---ILQKKQQLQMEV 559
+ + +V+ I ++ M+ + L +++ ++ ++++ Q+ Q
Sbjct: 1552 ------MFSKDKTFIVRQSIHDEISVSSMDASRQLMLNEEQLEDMRQELVRQYQEHQQAT 1605
Query: 560 KMLSSS--KSMKELTEEQQNLQKELESLQNEHAQR-----------MEEFYVEQKDLEKK 606
++L + + M+ E+Q+ LQ+E++ L + AQR E +E+ + K+
Sbjct: 1606 ELLRQAHMRQMERQREDQEQLQEEIKRLNRQLAQRSSIDNENLVSERERVLLEELEALKQ 1665
Query: 607 LEQIMKQKCTCD---SNLEKDKEAEYAGQLAELRQRLDHAEADR--QELQDE-LRQEREA 660
L ++K C+ S+ + E G++ E Q E DR +++ E L ER A
Sbjct: 1666 LSLAGREKLCCELRNSSTQTQNGNENQGEVEE--QTFKEKELDRKPEDVPPEILSNERYA 1723
Query: 661 RQKLEMMIKELKLQILKSSKTAKE 684
QK + ++ L+++K++ +E
Sbjct: 1724 LQKANNRLLKILLEVVKTTAAVEE 1747
Score = 47.8 bits (112), Expect = 3e-05
Identities = 38/147 (25%), Positives = 75/147 (51%), Gaps = 7/147 (4%)
Query: 532 EEVMRTYLKQQEKLNLILQKKQQL--QMEVKMLSSSKSMKELTEEQQNLQKELESL-QNE 588
E V+ Y ++ +Q+K + ++E ++L +S ++EL EQQ +Q+E E L + +
Sbjct: 1921 EGVIDGYADEKTLFERQIQEKTDIIDRLEQELLCASNRLQELEAEQQQIQEERELLSRQK 1980
Query: 589 HAQRMEEFYVEQKDLEKKLEQIMKQKCTCDSNLEK---DKEAEYAGQLAELRQRLDHAEA 645
A + E VEQ+ L ++ E++MK+K EK D + + ++ +++
Sbjct: 1981 EAMKAEAGPVEQQ-LLQETEKLMKEKLEVQCQAEKVRDDLQKQVKALEIDVEEQVSRFIE 2039
Query: 646 DRQELQDELRQEREARQKLEMMIKELK 672
QE EL R+ Q LE +++++
Sbjct: 2040 LEQEKNTELMDLRQQNQALEKQLEKMR 2066
Score = 46.6 bits (109), Expect = 8e-05
Identities = 64/310 (20%), Positives = 139/310 (44%), Gaps = 45/310 (14%)
Query: 413 VSLTSAVSQSKELTKTEASKSISRQSEKAHSSGKLQKTVS---YPDVSLEEQEKMDLKTS 469
+S TS+ + ++T+TE + RQ ++A S K Q+ + + + EQ ++L +
Sbjct: 1861 ISETSSQLEHAKVTQTELMRESFRQKQEATESLKCQEELRERLHEESRAREQLAVELSKA 1920
Query: 470 R---------------------ELCSRLDASI--SNNSTSKRKSESATCNLVRDINKVGI 506
++ RL+ + ++N + ++E R++
Sbjct: 1921 EGVIDGYADEKTLFERQIQEKTDIIDRLEQELLCASNRLQELEAEQQQIQEERELLSRQK 1980
Query: 507 GLVAAASSPLLVKDVICEDDKGKIMEEVMRTYLKQQEKLNLILQKK-QQLQMEVKMLSS- 564
+ A + P V+ + ++ + K+M+E + Q EK+ LQK+ + L+++V+ S
Sbjct: 1981 EAMKAEAGP--VEQQLLQETE-KLMKEKLEVQC-QAEKVRDDLQKQVKALEIDVEEQVSR 2036
Query: 565 --------SKSMKELTEEQQNLQKELES----LQNEHAQRMEEFYVEQKDLEKKLEQIMK 612
+ + +L ++ Q L+K+LE L + R E V Q++++K +Q+
Sbjct: 2037 FIELEQEKNTELMDLRQQNQALEKQLEKMRKFLDEQAIDREHERDVFQQEIQKLEQQLKV 2096
Query: 613 QKCTCDSNLEKDKEAEY-AGQLAELRQRLDHAEADRQELQDELRQEREARQKLEMMIKEL 671
+ + +E E A L E + +++LQ ++++ E +KLE ++EL
Sbjct: 2097 VPRFQPISEHQTREVEQLANHLKEKTDKCSELLLSKEQLQRDIQERNEEIEKLEFRVREL 2156
Query: 672 KLQILKSSKT 681
+ +L S+ T
Sbjct: 2157 EQALLVSADT 2166
Score = 43.1 bits (100), Expect = 8e-04
Identities = 74/392 (18%), Positives = 164/392 (41%), Gaps = 61/392 (15%)
Query: 338 TPEEKKLKIILEEMKEKFSMRSGKRNQSKTDAPSGMELQSWYPVIKQEGDHVSQTH---- 393
T + +KL+I ++++ ++R+ + + D + + +E DH+ + +
Sbjct: 232 TEQSQKLQIQFQQLQASETLRNSTHSSTAADLLQAKQQILTHQQQLEEQDHLLEDYQKKK 291
Query: 394 -------SFLHPSYYLYMCDKVVAPNVSLTSAVSQSKELTKTEASKSISRQSEKAHSSGK 446
SFL +Y ++ S + Q KE E + I + +K +
Sbjct: 292 EDFTMQISFLQEKIKVYEMEQDKKVENSNKEEI-QEKETIIEELNTKIIEEEKKTL---E 347
Query: 447 LQKTVSYPDVSLEEQEKMDLKTSRELCSRLDASISNNSTSKRKSESATCNLVRDINKVGI 506
L+ ++ D L E ++ ++ ++E+ + ++N+ +R+S L+ + ++
Sbjct: 348 LKDKLTTADKLLGELQEQIVQKNQEI-KNMKLELTNSKQKERQSSEEIKQLMGTVEEL-- 404
Query: 507 GLVAAASSPLLVKDVICEDDKGKIMEEVMRTYLKQ-QEKLN-----LILQKKQQL----- 555
KD E D + ME+ + L+Q + +L+ I+Q KQ+L
Sbjct: 405 -------QKRNHKDSQFETDIVQRMEQETQRKLEQLRAELDEMYGQQIVQMKQELIRQHM 457
Query: 556 -QMEVKMLSSSKSMKELTEEQQNLQKELESLQ------NEHAQRMEEFYVEQKDLEKKLE 608
QME M+ N+ + ++ NE ++++ +++ L+++L
Sbjct: 458 AQMEEMKTRHKGEMENALRSYSNITVNEDQIKLMNVAINELNIKLQDTNSQKEKLKEELG 517
Query: 609 QIMKQKCTCDSNLE--------KDKEAEYAGQ-LAELRQRLDHAEADRQELQD------- 652
I+++KC LE ++ + A Q +AE +L+ A ++D
Sbjct: 518 LILEEKCALQRQLEDLVEELSFSREQIQRARQTIAEQESKLNEAHKSLSTVEDLKAEIVS 577
Query: 653 --ELRQEREARQKLEMMIKELKLQILKSSKTA 682
E R+E E + + E+ ++KL++L+ K A
Sbjct: 578 ASESRKELELKHEAEVTNYKIKLEMLEKEKNA 609
Score = 39.3 bits (90), Expect = 0.012
Identities = 43/153 (28%), Positives = 74/153 (48%), Gaps = 22/153 (14%)
Query: 541 QQEKLNLILQKKQQLQMEVKMLS-------SSKSMKELTEEQQNLQKELESLQNEHAQR- 592
Q EK NLI K+ QL +E+ L +SKS +E+T + LQKE+E L+ E ++
Sbjct: 682 QFEKDNLIT-KQNQLILEISKLKDLQQSLVNSKS-EEMTLQINELQKEIEILRQEEKEKG 739
Query: 593 -MEEFYVEQKDLEKKLEQIMKQKCTCDSNLEKDKEAEYAGQLAELRQRLDHAEADRQELQ 651
+E+ E ++L+ K E + KQ K+KE + + A+L + +++ L+
Sbjct: 740 TLEQ---EVQELQLKTELLEKQM--------KEKENDLQEKFAQLEAENSILKDEKKTLE 788
Query: 652 DELRQEREARQKLEMMIKELKLQILKSSKTAKE 684
D L+ Q+ ++ + K S KE
Sbjct: 789 DMLKIHTPVSQEERLIFLDSIKSKSKDSVWEKE 821
Score = 39.3 bits (90), Expect = 0.012
Identities = 68/329 (20%), Positives = 140/329 (42%), Gaps = 38/329 (11%)
Query: 340 EEKKLKIILEEMKEKFSMRSGKRNQSKTD-APSGMELQSWYPVIKQEGDHVSQTHSFLHP 398
E +K E++E+ S + K++ A + +EL++ +K + H+ + +F
Sbjct: 3139 ELSSMKDRATELQEQLSSEKMVVAELKSELAQTKLELET---TLKAQHKHLKELEAFR-- 3193
Query: 399 SYYLYMCDKVVAPNVSLTSAVSQSKELTKTEASKSISRQSEKAHSSGKLQKT-VSYPDVS 457
L + DK V L + S++ E ++ ++ K S + K + S
Sbjct: 3194 ---LEVKDKT--DEVHLLNDTLASEQKKSRELQWALEKEKAKLGRSEERDKEELEDLKFS 3248
Query: 458 LEEQEKMDLKTSRELCSRLDASISNNSTSKRKSESATCNLVRDINKVGIGLVAAASSPLL 517
LE Q++ +L+ + L + N S K +S+ ++ D ++ L
Sbjct: 3249 LESQKQRNLQLN--LLLEQQKQLLNESQQKIESQ----RMLYDAQ------LSEEQGRNL 3296
Query: 518 VKDVICEDDKGKIMEEVMRTYLKQQEKLNLILQKKQQLQMEVKMLSSSKSMKELTEEQQN 577
V+ E +K +I E M + L ++ +L+ LQ L S +KEL
Sbjct: 3297 ELQVLLESEKVRIRE--MSSTLDRERELHAQLQSSDGTGQSRPPLPSEDLLKEL------ 3348
Query: 578 LQKELESLQNEHAQRMEEFYVEQKDLEKKLEQIMKQKCTCDSNLEKDKEAEYAGQLAELR 637
QK+LE + + + E + D + +Q+ K + L+ ++EA GQ
Sbjct: 3349 -QKQLEEKHSRIVELLNETEKYKLDSLQTRQQMEKDRQVHRKTLQTEQEANTEGQ----- 3402
Query: 638 QRLDHAEADRQELQDELRQEREARQKLEM 666
+++ ++ ++LQ +L ++R+ KL++
Sbjct: 3403 KKMHELQSKVEDLQRQLEEKRQQVYKLDL 3431
Score = 38.5 bits (88), Expect = 0.021
Identities = 42/169 (24%), Positives = 84/169 (49%), Gaps = 18/169 (10%)
Query: 524 EDDKGKIMEEVMRTYLK-------QQEKLNLILQKKQQLQMEVKML-SSSKSMKELTEEQ 575
E +KG + +EV LK +EK N + +K QL+ E +L K+++++ +
Sbjct: 735 EKEKGTLEQEVQELQLKTELLEKQMKEKENDLQEKFAQLEAENSILKDEKKTLEDMLKIH 794
Query: 576 QNLQKELESLQNEHAQRMEEFYVEQKDLEKKLE--QIMKQKC-TCDSNLEKDKEA-EYAG 631
+ +E + + + + V +K++E +E + +KQ+C + +EK + +A
Sbjct: 795 TPVSQEERLIFLDSIKSKSKDSVWEKEIEILIEENEDLKQQCIQLNEEIEKQRNTFSFAE 854
Query: 632 QLAELR-QRLDHAEADRQELQDEL-----RQEREARQKLEMMIKELKLQ 674
+ E+ Q L A +++D+L +QE E + KL+ + +EL LQ
Sbjct: 855 KNFEVNYQELQEEYACLLKVKDDLEDSKNKQELEYKSKLKALNEELHLQ 903
Score = 38.1 bits (87), Expect = 0.027
Identities = 36/175 (20%), Positives = 82/175 (46%), Gaps = 22/175 (12%)
Query: 532 EEVMRTYLK---QQEKLNLILQKKQQ----------------LQMEVKMLSSSKSMKELT 572
+E MR +L+ Q +KL + Q+ Q LQ + ++L+ + ++E
Sbjct: 222 DETMREFLELTEQSQKLQIQFQQLQASETLRNSTHSSTAADLLQAKQQILTHQQQLEEQD 281
Query: 573 EEQQNLQKELESLQNEHAQRMEEFYVEQKDLEKKLEQIMKQKCTCDSNLEKD---KEAEY 629
++ QK+ E + + E+ V + + +KK+E K++ + ++ K E
Sbjct: 282 HLLEDYQKKKEDFTMQISFLQEKIKVYEMEQDKKVENSNKEEIQEKETIIEELNTKIIEE 341
Query: 630 AGQLAELRQRLDHAEADRQELQDELRQEREARQKLEMMIKELKLQILKSSKTAKE 684
+ EL+ +L A+ ELQ+++ Q+ + + +++ + K + +SS+ K+
Sbjct: 342 EKKTLELKDKLTTADKLLGELQEQIVQKNQEIKNMKLELTNSKQKERQSSEEIKQ 396
Score = 36.2 bits (82), Expect = 0.10
Identities = 39/173 (22%), Positives = 79/173 (45%), Gaps = 36/173 (20%)
Query: 524 EDDKGKIMEEVMRTYLKQQEKLNLILQ------KKQQLQMEVKMLSSSKSMKELTEEQQN 577
E + K +E++ ++Q++ L +Q K + +++ ++ S + EL E
Sbjct: 3111 EQESEKPSQELLEYNIQQKQSQMLEMQVELSSMKDRATELQEQLSSEKMVVAELKSELAQ 3170
Query: 578 LQKELESL---QNEHAQRMEEFYVEQKDL--------------EKKLEQIM----KQKCT 616
+ ELE+ Q++H + +E F +E KD +KK ++ K+K
Sbjct: 3171 TKLELETTLKAQHKHLKELEAFRLEVKDKTDEVHLLNDTLASEQKKSRELQWALEKEKAK 3230
Query: 617 CDSNLEKDKEAEYAGQLAELRQRLDHAEADRQELQDELRQER----EARQKLE 665
+ E+DKE +L +L+ L+ + +L L Q++ E++QK+E
Sbjct: 3231 LGRSEERDKE-----ELEDLKFSLESQKQRNLQLNLLLEQQKQLLNESQQKIE 3278
Score = 35.4 bits (80), Expect = 0.18
Identities = 57/284 (20%), Positives = 131/284 (46%), Gaps = 30/284 (10%)
Query: 413 VSLTSAVSQSKELTKTEASKSI---SRQSEKAHSSGKLQKTVSYPDVSLEEQE--KMDLK 467
V L+S ++ EL + +S+ + +SE A + +L+ T+ L+E E ++++K
Sbjct: 3138 VELSSMKDRATELQEQLSSEKMVVAELKSELAQTKLELETTLKAQHKHLKELEAFRLEVK 3197
Query: 468 TSRELCSRLDASISNNSTSKRKSESATCNLVRDINKVGIG-------------LVAAASS 514
+ L+ ++++ R+ + A L ++ K+G + +
Sbjct: 3198 DKTDEVHLLNDTLASEQKKSRELQWA---LEKEKAKLGRSEERDKEELEDLKFSLESQKQ 3254
Query: 515 PLLVKDVICEDDKGKIMEEVMRTYLKQQEKLNLILQKKQQLQMEVKMLSSSKSMKELTEE 574
L +++ E K +++ E + Q+ + L ++Q +E+++L S+ ++ + E
Sbjct: 3255 RNLQLNLLLEQQK-QLLNESQQKIESQRMLYDAQLSEEQGRNLELQVLLESEKVR-IREM 3312
Query: 575 QQNLQKELE---SLQNEHAQRMEEFYVEQKDLEKKLEQIMKQKCTCDSNLEKDKEAEYAG 631
L +E E LQ+ + +DL K+L++ +++K + L + E +Y
Sbjct: 3313 SSTLDRERELHAQLQSSDGTGQSRPPLPSEDLLKELQKQLEEKHSRIVELLNETE-KYKL 3371
Query: 632 QLAELRQRLDHAEADRQELQDELRQEREARQKLEMMIKELKLQI 675
+ RQ++ E DRQ + L+ E+EA + + + EL+ ++
Sbjct: 3372 DSLQTRQQM---EKDRQVHRKTLQTEQEANTEGQKKMHELQSKV 3412
Score = 34.3 bits (77), Expect = 0.39
Identities = 32/152 (21%), Positives = 69/152 (45%), Gaps = 11/152 (7%)
Query: 542 QEKLNLILQKKQQLQ----MEVKMLSSSKSMKELTEEQQNLQKELESLQNEHAQRMEEFY 597
++ L I + QL+ + +++ S K+ E Q+EL +E ++ E+
Sbjct: 1855 EKLLEAISETSSQLEHAKVTQTELMRESFRQKQEATESLKCQEELRERLHEESRAREQLA 1914
Query: 598 VEQKDLEKKLEQIMKQKCTCDSNLEKDKEA--EYAGQLAELRQRLDHAEADRQELQDE-- 653
VE E ++ +K + +++ + +L RL EA++Q++Q+E
Sbjct: 1915 VELSKAEGVIDGYADEKTLFERQIQEKTDIIDRLEQELLCASNRLQELEAEQQQIQEERE 1974
Query: 654 -LRQEREARQKLEMMIKELKLQILKSSKTAKE 684
L +++EA + +++ LQ ++ K KE
Sbjct: 1975 LLSRQKEAMKAEAGPVEQQLLQ--ETEKLMKE 2004
Score = 33.5 bits (75), Expect = 0.67
Identities = 34/151 (22%), Positives = 72/151 (47%), Gaps = 11/151 (7%)
Query: 537 TYLKQQEKLNL-ILQKKQQLQMEVKMLSSSKSMKELTEEQQNLQKELESLQNEHAQRMEE 595
T+ K +++ + ++ K +L +EV++ + ++ +E NL+++LE + E + EE
Sbjct: 2166 TFQKVEDRKHFGAVEAKPELSLEVQLQAERDAIDRKEKEITNLEEQLEQFREELENKNEE 2225
Query: 596 FYVEQKDLEKKLEQIMKQKCTCDSNLEKDKEAEYAGQLAELRQRLDHAEADRQELQDE-- 653
+ L +LE K+ T LE++ + + + +L L E+D QD+
Sbjct: 2226 V----QQLHMQLEIQKKESTTRLQELEQENKL-FKDDMEKL--GLAIKESDAMSTQDQHV 2278
Query: 654 -LRQEREARQKLEMMIKELKLQILKSSKTAK 683
+ + Q+ E+ I +L Q+ K + K
Sbjct: 2279 LFGKFAQIIQEKEVEIDQLNEQVTKLQQQLK 2309
Score = 29.6 bits (65), Expect = 9.7
Identities = 37/141 (26%), Positives = 65/141 (46%), Gaps = 27/141 (19%)
Query: 540 KQQEKLNLILQKKQQLQMEVKMLSS--SKSMKELTEEQQNLQKELESLQNEHAQ--RMEE 595
K +E+L LIL++K LQ +++ L S S +++ +Q + ++ L H +E+
Sbjct: 511 KLKEELGLILEEKCALQRQLEDLVEELSFSREQIQRARQTIAEQESKLNEAHKSLSTVED 570
Query: 596 FYVE-------QKDLEKK-----------LEQIMKQKCTCDSNLEKDKEAEYAGQLAELR 637
E +K+LE K LE + K+K + + +EAE L LR
Sbjct: 571 LKAEIVSASESRKELELKHEAEVTNYKIKLEMLEKEKNAVLDRMAESQEAE----LERLR 626
Query: 638 -QRLDHAEADRQELQDELRQE 657
Q L E + +L+++L E
Sbjct: 627 TQLLFSHEEELSKLKEDLEIE 647
Score = 29.6 bits (65), Expect = 9.7
Identities = 19/74 (25%), Positives = 36/74 (48%)
Query: 540 KQQEKLNLILQKKQQLQMEVKMLSSSKSMKELTEEQQNLQKELESLQNEHAQRMEEFYVE 599
+Q + + L ++ + E + LS M L + N + +L SLQ+ ++EE E
Sbjct: 1283 QQTDGMKLEFGEENLPKEETEFLSIHSQMTNLEDIDVNHKSKLSSLQDLEKTKLEEQVQE 1342
Query: 600 QKDLEKKLEQIMKQ 613
+ L L+Q +K+
Sbjct: 1343 LESLISSLQQQLKE 1356
>gi|22538393 A-kinase anchor protein 9 isoform 3 [Homo sapiens]
Length = 3899
Score = 53.1 bits (126), Expect = 8e-07
Identities = 67/324 (20%), Positives = 142/324 (43%), Gaps = 43/324 (13%)
Query: 396 LHPSYYLYMCDKVVAPNVSLTSAVSQSKELTKTEASKSISRQSEKAHSSGKLQK------ 449
L Y + ++V VS++ A +Q EL++ K + S++AH+ + ++
Sbjct: 1432 LEKQYQEQLEEEVAKVIVSMSIAFAQQTELSRISGGKENTASSKQAHAVCQQEQHYFNEM 1491
Query: 450 TVSYPDVSLEEQEKMDLK-------TSRELCSRLDASISNNSTSKRKSESATCNLVRDIN 502
+S + + E +D+K S+EL + +NS ES C L
Sbjct: 1492 KLSQDQIGFQTFETVDVKFKEEFKPLSKELGEHGKEILLSNSDPHDIPESKDCVLTISEE 1551
Query: 503 KVGIGLVAAASSPLLVKDVICEDDKGKIMEEVMRTYLKQQEKLNL---ILQKKQQLQMEV 559
+ + +V+ I ++ M+ + L +++ ++ ++++ Q+ Q
Sbjct: 1552 ------MFSKDKTFIVRQSIHDEISVSSMDASRQLMLNEEQLEDMRQELVRQYQEHQQAT 1605
Query: 560 KMLSSS--KSMKELTEEQQNLQKELESLQNEHAQR-----------MEEFYVEQKDLEKK 606
++L + + M+ E+Q+ LQ+E++ L + AQR E +E+ + K+
Sbjct: 1606 ELLRQAHMRQMERQREDQEQLQEEIKRLNRQLAQRSSIDNENLVSERERVLLEELEALKQ 1665
Query: 607 LEQIMKQKCTCD---SNLEKDKEAEYAGQLAELRQRLDHAEADR--QELQDE-LRQEREA 660
L ++K C+ S+ + E G++ E Q E DR +++ E L ER A
Sbjct: 1666 LSLAGREKLCCELRNSSTQTQNGNENQGEVEE--QTFKEKELDRKPEDVPPEILSNERYA 1723
Query: 661 RQKLEMMIKELKLQILKSSKTAKE 684
QK + ++ L+++K++ +E
Sbjct: 1724 LQKANNRLLKILLEVVKTTAAVEE 1747
Score = 47.8 bits (112), Expect = 3e-05
Identities = 38/147 (25%), Positives = 75/147 (51%), Gaps = 7/147 (4%)
Query: 532 EEVMRTYLKQQEKLNLILQKKQQL--QMEVKMLSSSKSMKELTEEQQNLQKELESL-QNE 588
E V+ Y ++ +Q+K + ++E ++L +S ++EL EQQ +Q+E E L + +
Sbjct: 1921 EGVIDGYADEKTLFERQIQEKTDIIDRLEQELLCASNRLQELEAEQQQIQEERELLSRQK 1980
Query: 589 HAQRMEEFYVEQKDLEKKLEQIMKQKCTCDSNLEK---DKEAEYAGQLAELRQRLDHAEA 645
A + E VEQ+ L ++ E++MK+K EK D + + ++ +++
Sbjct: 1981 EAMKAEAGPVEQQ-LLQETEKLMKEKLEVQCQAEKVRDDLQKQVKALEIDVEEQVSRFIE 2039
Query: 646 DRQELQDELRQEREARQKLEMMIKELK 672
QE EL R+ Q LE +++++
Sbjct: 2040 LEQEKNTELMDLRQQNQALEKQLEKMR 2066
Score = 43.9 bits (102), Expect = 5e-04
Identities = 62/305 (20%), Positives = 136/305 (44%), Gaps = 45/305 (14%)
Query: 413 VSLTSAVSQSKELTKTEASKSISRQSEKAHSSGKLQKTVS---YPDVSLEEQEKMDLKTS 469
+S TS+ + ++T+TE + RQ ++A S K Q+ + + + EQ ++L +
Sbjct: 1861 ISETSSQLEHAKVTQTELMRESFRQKQEATESLKCQEELRERLHEESRAREQLAVELSKA 1920
Query: 470 R---------------------ELCSRLDASI--SNNSTSKRKSESATCNLVRDINKVGI 506
++ RL+ + ++N + ++E R++
Sbjct: 1921 EGVIDGYADEKTLFERQIQEKTDIIDRLEQELLCASNRLQELEAEQQQIQEERELLSRQK 1980
Query: 507 GLVAAASSPLLVKDVICEDDKGKIMEEVMRTYLKQQEKLNLILQKK-QQLQMEVKMLSS- 564
+ A + P V+ + ++ + K+M+E + Q EK+ LQK+ + L+++V+ S
Sbjct: 1981 EAMKAEAGP--VEQQLLQETE-KLMKEKLEVQC-QAEKVRDDLQKQVKALEIDVEEQVSR 2036
Query: 565 --------SKSMKELTEEQQNLQKELES----LQNEHAQRMEEFYVEQKDLEKKLEQIMK 612
+ + +L ++ Q L+K+LE L + R E V Q++++K +Q+
Sbjct: 2037 FIELEQEKNTELMDLRQQNQALEKQLEKMRKFLDEQAIDREHERDVFQQEIQKLEQQLKV 2096
Query: 613 QKCTCDSNLEKDKEAEY-AGQLAELRQRLDHAEADRQELQDELRQEREARQKLEMMIKEL 671
+ + +E E A L E + +++LQ ++++ E +KLE ++EL
Sbjct: 2097 VPRFQPISEHQTREVEQLANHLKEKTDKCSELLLSKEQLQRDIQERNEEIEKLEFRVREL 2156
Query: 672 KLQIL 676
+ +L
Sbjct: 2157 EQALL 2161
Score = 43.1 bits (100), Expect = 8e-04
Identities = 74/392 (18%), Positives = 164/392 (41%), Gaps = 61/392 (15%)
Query: 338 TPEEKKLKIILEEMKEKFSMRSGKRNQSKTDAPSGMELQSWYPVIKQEGDHVSQTH---- 393
T + +KL+I ++++ ++R+ + + D + + +E DH+ + +
Sbjct: 232 TEQSQKLQIQFQQLQASETLRNSTHSSTAADLLQAKQQILTHQQQLEEQDHLLEDYQKKK 291
Query: 394 -------SFLHPSYYLYMCDKVVAPNVSLTSAVSQSKELTKTEASKSISRQSEKAHSSGK 446
SFL +Y ++ S + Q KE E + I + +K +
Sbjct: 292 EDFTMQISFLQEKIKVYEMEQDKKVENSNKEEI-QEKETIIEELNTKIIEEEKKTL---E 347
Query: 447 LQKTVSYPDVSLEEQEKMDLKTSRELCSRLDASISNNSTSKRKSESATCNLVRDINKVGI 506
L+ ++ D L E ++ ++ ++E+ + ++N+ +R+S L+ + ++
Sbjct: 348 LKDKLTTADKLLGELQEQIVQKNQEI-KNMKLELTNSKQKERQSSEEIKQLMGTVEEL-- 404
Query: 507 GLVAAASSPLLVKDVICEDDKGKIMEEVMRTYLKQ-QEKLN-----LILQKKQQL----- 555
KD E D + ME+ + L+Q + +L+ I+Q KQ+L
Sbjct: 405 -------QKRNHKDSQFETDIVQRMEQETQRKLEQLRAELDEMYGQQIVQMKQELIRQHM 457
Query: 556 -QMEVKMLSSSKSMKELTEEQQNLQKELESLQ------NEHAQRMEEFYVEQKDLEKKLE 608
QME M+ N+ + ++ NE ++++ +++ L+++L
Sbjct: 458 AQMEEMKTRHKGEMENALRSYSNITVNEDQIKLMNVAINELNIKLQDTNSQKEKLKEELG 517
Query: 609 QIMKQKCTCDSNLE--------KDKEAEYAGQ-LAELRQRLDHAEADRQELQD------- 652
I+++KC LE ++ + A Q +AE +L+ A ++D
Sbjct: 518 LILEEKCALQRQLEDLVEELSFSREQIQRARQTIAEQESKLNEAHKSLSTVEDLKAEIVS 577
Query: 653 --ELRQEREARQKLEMMIKELKLQILKSSKTA 682
E R+E E + + E+ ++KL++L+ K A
Sbjct: 578 ASESRKELELKHEAEVTNYKIKLEMLEKEKNA 609
Score = 39.3 bits (90), Expect = 0.012
Identities = 43/153 (28%), Positives = 74/153 (48%), Gaps = 22/153 (14%)
Query: 541 QQEKLNLILQKKQQLQMEVKMLS-------SSKSMKELTEEQQNLQKELESLQNEHAQR- 592
Q EK NLI K+ QL +E+ L +SKS +E+T + LQKE+E L+ E ++
Sbjct: 682 QFEKDNLIT-KQNQLILEISKLKDLQQSLVNSKS-EEMTLQINELQKEIEILRQEEKEKG 739
Query: 593 -MEEFYVEQKDLEKKLEQIMKQKCTCDSNLEKDKEAEYAGQLAELRQRLDHAEADRQELQ 651
+E+ E ++L+ K E + KQ K+KE + + A+L + +++ L+
Sbjct: 740 TLEQ---EVQELQLKTELLEKQM--------KEKENDLQEKFAQLEAENSILKDEKKTLE 788
Query: 652 DELRQEREARQKLEMMIKELKLQILKSSKTAKE 684
D L+ Q+ ++ + K S KE
Sbjct: 789 DMLKIHTPVSQEERLIFLDSIKSKSKDSVWEKE 821
Score = 39.3 bits (90), Expect = 0.012
Identities = 68/329 (20%), Positives = 140/329 (42%), Gaps = 38/329 (11%)
Query: 340 EEKKLKIILEEMKEKFSMRSGKRNQSKTD-APSGMELQSWYPVIKQEGDHVSQTHSFLHP 398
E +K E++E+ S + K++ A + +EL++ +K + H+ + +F
Sbjct: 3131 ELSSMKDRATELQEQLSSEKMVVAELKSELAQTKLELET---TLKAQHKHLKELEAFR-- 3185
Query: 399 SYYLYMCDKVVAPNVSLTSAVSQSKELTKTEASKSISRQSEKAHSSGKLQKT-VSYPDVS 457
L + DK V L + S++ E ++ ++ K S + K + S
Sbjct: 3186 ---LEVKDKT--DEVHLLNDTLASEQKKSRELQWALEKEKAKLGRSEERDKEELEDLKFS 3240
Query: 458 LEEQEKMDLKTSRELCSRLDASISNNSTSKRKSESATCNLVRDINKVGIGLVAAASSPLL 517
LE Q++ +L+ + L + N S K +S+ ++ D ++ L
Sbjct: 3241 LESQKQRNLQLN--LLLEQQKQLLNESQQKIESQ----RMLYDAQ------LSEEQGRNL 3288
Query: 518 VKDVICEDDKGKIMEEVMRTYLKQQEKLNLILQKKQQLQMEVKMLSSSKSMKELTEEQQN 577
V+ E +K +I E M + L ++ +L+ LQ L S +KEL
Sbjct: 3289 ELQVLLESEKVRIRE--MSSTLDRERELHAQLQSSDGTGQSRPPLPSEDLLKEL------ 3340
Query: 578 LQKELESLQNEHAQRMEEFYVEQKDLEKKLEQIMKQKCTCDSNLEKDKEAEYAGQLAELR 637
QK+LE + + + E + D + +Q+ K + L+ ++EA GQ
Sbjct: 3341 -QKQLEEKHSRIVELLNETEKYKLDSLQTRQQMEKDRQVHRKTLQTEQEANTEGQ----- 3394
Query: 638 QRLDHAEADRQELQDELRQEREARQKLEM 666
+++ ++ ++LQ +L ++R+ KL++
Sbjct: 3395 KKMHELQSKVEDLQRQLEEKRQQVYKLDL 3423
Score = 38.5 bits (88), Expect = 0.021
Identities = 42/169 (24%), Positives = 84/169 (49%), Gaps = 18/169 (10%)
Query: 524 EDDKGKIMEEVMRTYLK-------QQEKLNLILQKKQQLQMEVKML-SSSKSMKELTEEQ 575
E +KG + +EV LK +EK N + +K QL+ E +L K+++++ +
Sbjct: 735 EKEKGTLEQEVQELQLKTELLEKQMKEKENDLQEKFAQLEAENSILKDEKKTLEDMLKIH 794
Query: 576 QNLQKELESLQNEHAQRMEEFYVEQKDLEKKLE--QIMKQKC-TCDSNLEKDKEA-EYAG 631
+ +E + + + + V +K++E +E + +KQ+C + +EK + +A
Sbjct: 795 TPVSQEERLIFLDSIKSKSKDSVWEKEIEILIEENEDLKQQCIQLNEEIEKQRNTFSFAE 854
Query: 632 QLAELR-QRLDHAEADRQELQDEL-----RQEREARQKLEMMIKELKLQ 674
+ E+ Q L A +++D+L +QE E + KL+ + +EL LQ
Sbjct: 855 KNFEVNYQELQEEYACLLKVKDDLEDSKNKQELEYKSKLKALNEELHLQ 903
Score = 38.1 bits (87), Expect = 0.027
Identities = 36/175 (20%), Positives = 82/175 (46%), Gaps = 22/175 (12%)
Query: 532 EEVMRTYLK---QQEKLNLILQKKQQ----------------LQMEVKMLSSSKSMKELT 572
+E MR +L+ Q +KL + Q+ Q LQ + ++L+ + ++E
Sbjct: 222 DETMREFLELTEQSQKLQIQFQQLQASETLRNSTHSSTAADLLQAKQQILTHQQQLEEQD 281
Query: 573 EEQQNLQKELESLQNEHAQRMEEFYVEQKDLEKKLEQIMKQKCTCDSNLEKD---KEAEY 629
++ QK+ E + + E+ V + + +KK+E K++ + ++ K E
Sbjct: 282 HLLEDYQKKKEDFTMQISFLQEKIKVYEMEQDKKVENSNKEEIQEKETIIEELNTKIIEE 341
Query: 630 AGQLAELRQRLDHAEADRQELQDELRQEREARQKLEMMIKELKLQILKSSKTAKE 684
+ EL+ +L A+ ELQ+++ Q+ + + +++ + K + +SS+ K+
Sbjct: 342 EKKTLELKDKLTTADKLLGELQEQIVQKNQEIKNMKLELTNSKQKERQSSEEIKQ 396
Score = 36.2 bits (82), Expect = 0.10
Identities = 39/173 (22%), Positives = 79/173 (45%), Gaps = 36/173 (20%)
Query: 524 EDDKGKIMEEVMRTYLKQQEKLNLILQ------KKQQLQMEVKMLSSSKSMKELTEEQQN 577
E + K +E++ ++Q++ L +Q K + +++ ++ S + EL E
Sbjct: 3103 EQESEKPSQELLEYNIQQKQSQMLEMQVELSSMKDRATELQEQLSSEKMVVAELKSELAQ 3162
Query: 578 LQKELESL---QNEHAQRMEEFYVEQKDL--------------EKKLEQIM----KQKCT 616
+ ELE+ Q++H + +E F +E KD +KK ++ K+K
Sbjct: 3163 TKLELETTLKAQHKHLKELEAFRLEVKDKTDEVHLLNDTLASEQKKSRELQWALEKEKAK 3222
Query: 617 CDSNLEKDKEAEYAGQLAELRQRLDHAEADRQELQDELRQER----EARQKLE 665
+ E+DKE +L +L+ L+ + +L L Q++ E++QK+E
Sbjct: 3223 LGRSEERDKE-----ELEDLKFSLESQKQRNLQLNLLLEQQKQLLNESQQKIE 3270
Score = 35.4 bits (80), Expect = 0.18
Identities = 57/284 (20%), Positives = 131/284 (46%), Gaps = 30/284 (10%)
Query: 413 VSLTSAVSQSKELTKTEASKSI---SRQSEKAHSSGKLQKTVSYPDVSLEEQE--KMDLK 467
V L+S ++ EL + +S+ + +SE A + +L+ T+ L+E E ++++K
Sbjct: 3130 VELSSMKDRATELQEQLSSEKMVVAELKSELAQTKLELETTLKAQHKHLKELEAFRLEVK 3189
Query: 468 TSRELCSRLDASISNNSTSKRKSESATCNLVRDINKVGIG-------------LVAAASS 514
+ L+ ++++ R+ + A L ++ K+G + +
Sbjct: 3190 DKTDEVHLLNDTLASEQKKSRELQWA---LEKEKAKLGRSEERDKEELEDLKFSLESQKQ 3246
Query: 515 PLLVKDVICEDDKGKIMEEVMRTYLKQQEKLNLILQKKQQLQMEVKMLSSSKSMKELTEE 574
L +++ E K +++ E + Q+ + L ++Q +E+++L S+ ++ + E
Sbjct: 3247 RNLQLNLLLEQQK-QLLNESQQKIESQRMLYDAQLSEEQGRNLELQVLLESEKVR-IREM 3304
Query: 575 QQNLQKELE---SLQNEHAQRMEEFYVEQKDLEKKLEQIMKQKCTCDSNLEKDKEAEYAG 631
L +E E LQ+ + +DL K+L++ +++K + L + E +Y
Sbjct: 3305 SSTLDRERELHAQLQSSDGTGQSRPPLPSEDLLKELQKQLEEKHSRIVELLNETE-KYKL 3363
Query: 632 QLAELRQRLDHAEADRQELQDELRQEREARQKLEMMIKELKLQI 675
+ RQ++ E DRQ + L+ E+EA + + + EL+ ++
Sbjct: 3364 DSLQTRQQM---EKDRQVHRKTLQTEQEANTEGQKKMHELQSKV 3404
Score = 34.3 bits (77), Expect = 0.39
Identities = 32/152 (21%), Positives = 69/152 (45%), Gaps = 11/152 (7%)
Query: 542 QEKLNLILQKKQQLQ----MEVKMLSSSKSMKELTEEQQNLQKELESLQNEHAQRMEEFY 597
++ L I + QL+ + +++ S K+ E Q+EL +E ++ E+
Sbjct: 1855 EKLLEAISETSSQLEHAKVTQTELMRESFRQKQEATESLKCQEELRERLHEESRAREQLA 1914
Query: 598 VEQKDLEKKLEQIMKQKCTCDSNLEKDKEA--EYAGQLAELRQRLDHAEADRQELQDE-- 653
VE E ++ +K + +++ + +L RL EA++Q++Q+E
Sbjct: 1915 VELSKAEGVIDGYADEKTLFERQIQEKTDIIDRLEQELLCASNRLQELEAEQQQIQEERE 1974
Query: 654 -LRQEREARQKLEMMIKELKLQILKSSKTAKE 684
L +++EA + +++ LQ ++ K KE
Sbjct: 1975 LLSRQKEAMKAEAGPVEQQLLQ--ETEKLMKE 2004
Score = 34.3 bits (77), Expect = 0.39
Identities = 35/156 (22%), Positives = 72/156 (46%), Gaps = 10/156 (6%)
Query: 531 MEEVMRTYLKQQEKLNLILQKKQQLQMEVKMLSSSKSMKELTEEQQNLQKELESLQNEHA 590
+ E+ + L + K ++ K +L +EV++ + ++ +E NL+++LE + E
Sbjct: 2153 VRELEQALLVEDRKHFGAVEAKPELSLEVQLQAERDAIDRKEKEITNLEEQLEQFREELE 2212
Query: 591 QRMEEFYVEQKDLEKKLEQIMKQKCTCDSNLEKDKEAEYAGQLAELRQRLDHAEADRQEL 650
+ EE + L +LE K+ T LE++ + + + +L L E+D
Sbjct: 2213 NKNEEV----QQLHMQLEIQKKESTTRLQELEQENKL-FKDDMEKL--GLAIKESDAMST 2265
Query: 651 QDE---LRQEREARQKLEMMIKELKLQILKSSKTAK 683
QD+ + + Q+ E+ I +L Q+ K + K
Sbjct: 2266 QDQHVLFGKFAQIIQEKEVEIDQLNEQVTKLQQQLK 2301
Score = 29.6 bits (65), Expect = 9.7
Identities = 37/141 (26%), Positives = 65/141 (46%), Gaps = 27/141 (19%)
Query: 540 KQQEKLNLILQKKQQLQMEVKMLSS--SKSMKELTEEQQNLQKELESLQNEHAQ--RMEE 595
K +E+L LIL++K LQ +++ L S S +++ +Q + ++ L H +E+
Sbjct: 511 KLKEELGLILEEKCALQRQLEDLVEELSFSREQIQRARQTIAEQESKLNEAHKSLSTVED 570
Query: 596 FYVE-------QKDLEKK-----------LEQIMKQKCTCDSNLEKDKEAEYAGQLAELR 637
E +K+LE K LE + K+K + + +EAE L LR
Sbjct: 571 LKAEIVSASESRKELELKHEAEVTNYKIKLEMLEKEKNAVLDRMAESQEAE----LERLR 626
Query: 638 -QRLDHAEADRQELQDELRQE 657
Q L E + +L+++L E
Sbjct: 627 TQLLFSHEEELSKLKEDLEIE 647
Score = 29.6 bits (65), Expect = 9.7
Identities = 19/74 (25%), Positives = 36/74 (48%)
Query: 540 KQQEKLNLILQKKQQLQMEVKMLSSSKSMKELTEEQQNLQKELESLQNEHAQRMEEFYVE 599
+Q + + L ++ + E + LS M L + N + +L SLQ+ ++EE E
Sbjct: 1283 QQTDGMKLEFGEENLPKEETEFLSIHSQMTNLEDIDVNHKSKLSSLQDLEKTKLEEQVQE 1342
Query: 600 QKDLEKKLEQIMKQ 613
+ L L+Q +K+
Sbjct: 1343 LESLISSLQQQLKE 1356
Database: hs.faa
Posted date: Aug 4, 2009 4:42 PM
Number of letters in database: 18,247,518
Number of sequences in database: 37,866
Lambda K H
0.313 0.128 0.364
Gapped
Lambda K H
0.267 0.0410 0.140
Matrix: BLOSUM62
Gap Penalties: Existence: 11, Extension: 1
Number of Hits to DB: 25,997,556
Number of Sequences: 37866
Number of extensions: 1288629
Number of successful extensions: 11704
Number of sequences better than 10.0: 30
Number of HSP's better than 10.0 without gapping: 280
Number of HSP's successfully gapped in prelim test: 988
Number of HSP's that attempted gapping in prelim test: 5915
Number of HSP's gapped (non-prelim): 4395
length of query: 684
length of database: 18,247,518
effective HSP length: 109
effective length of query: 575
effective length of database: 14,120,124
effective search space: 8119071300
effective search space used: 8119071300
T: 11
A: 40
X1: 16 ( 7.2 bits)
X2: 38 (14.6 bits)
X3: 64 (24.7 bits)
S1: 42 (22.0 bits)
S2: 65 (29.6 bits)
Search results were obtained with NCBI BLAST and RefSeq entries.
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Guide to the Human Genome
Copyright © 2010 by Stewart Scherer. All rights reserved.