Search of human proteins with 222831573

Search of human proteins with 222831573

BLASTP 2.2.11 [Jun-05-2005]


Reference: Altschul, Stephen F., Thomas L. Madden, Alejandro A. Schaffer, 
Jinghui Zhang, Zheng Zhang, Webb Miller, and David J. Lipman (1997), 
"Gapped BLAST and PSI-BLAST: a new generation of protein database search
programs",  Nucleic Acids Res. 25:3389-3402.

Query= gi|222831573 solute carrier organic anion transporter family,
member 3A1 isoform 2 [Homo sapiens]
         (692 letters)

Database: hs.faa 
           37,866 sequences; 18,247,518 total letters

Searching..................................................done

                                                                 Score    E
Sequences producing significant alignments:                      (bits) Value

gi|222831573 solute carrier organic anion transporter family, me...  1408   0.0  
gi|222831575 solute carrier organic anion transporter family, me...  1354   0.0  
gi|8394291 solute carrier organic anion transporter family, memb...   414   e-115
gi|188528663 solute carrier organic anion transporter family, me...   412   e-115
gi|225543118 solute carrier organic anion transporter family, me...   403   e-112
gi|225637473 solute carrier organic anion transporter family, me...   397   e-110
gi|9790233 solute carrier organic anion transporter family, memb...   395   e-110
gi|10835099 organic anion transporting polypeptide A [Homo sapiens]   391   e-108
gi|19913403 organic anion transporting polypeptide A [Homo sapiens]   391   e-108
gi|225543525 solute carrier organic anion transporter family, me...   385   e-107
gi|223634012 solute carrier organic anion transporter family, me...   384   e-106
gi|6005820 solute carrier organic anion transporter family, memb...   384   e-106
gi|225543116 solute carrier organic anion transporter family, me...   373   e-103
gi|38679890 solute carrier organic anion transporter family, mem...   358   9e-99
gi|39777594 solute carrier organic anion transporter family memb...   351   1e-96
gi|116812593 liver-specific organic anion transporter 3TM12 [Hom...   342   7e-94
gi|225637475 solute carrier organic anion transporter family, me...   331   2e-90
gi|225543114 solute carrier organic anion transporter family, me...   324   1e-88
gi|225637477 solute carrier organic anion transporter family, me...   319   6e-87
gi|223634014 solute carrier organic anion transporter family, me...   293   3e-79
gi|93277099 solute carrier organic anion transporter family, mem...   228   1e-59
gi|11863156 RECK protein precursor [Homo sapiens]                      37   0.061
gi|238859649 keratin associated protein 10-8 [Homo sapiens]            36   0.10 
gi|118600977 C3 and PZP-like, alpha-2-macroglobulin domain conta...    35   0.18 
gi|54873613 agrin [Homo sapiens]                                       35   0.23 
gi|29568105 transmembrane protein with EGF-like and two follista...    33   0.68 
gi|169212028 PREDICTED: keratin-associated protein 9-2-like 2-li...    33   0.89 
gi|46250735 keratin associated protein 10-2 [Homo sapiens]             33   0.89 
gi|63053512 keratin associated protein 10-1 [Homo sapiens]             33   1.2  
gi|32140182 keratin associated protein 10-10 [Homo sapiens]            33   1.2  

>gi|222831573 solute carrier organic anion transporter family,
           member 3A1 isoform 2 [Homo sapiens]
          Length = 692

 Score = 1408 bits (3644), Expect = 0.0
 Identities = 692/692 (100%), Positives = 692/692 (100%)

Query: 1   MQGKKPGGSSGGGRSGELQGDEAQRNKKKKKKVSCFSNIKIFLVSECALMLAQGTVGAYL 60
           MQGKKPGGSSGGGRSGELQGDEAQRNKKKKKKVSCFSNIKIFLVSECALMLAQGTVGAYL
Sbjct: 1   MQGKKPGGSSGGGRSGELQGDEAQRNKKKKKKVSCFSNIKIFLVSECALMLAQGTVGAYL 60

Query: 61  VSVLTTLERRFNLQSADVGVIASSFEIGNLALILFVSYFGARGHRPRLIGCGGIVMALGA 120
           VSVLTTLERRFNLQSADVGVIASSFEIGNLALILFVSYFGARGHRPRLIGCGGIVMALGA
Sbjct: 61  VSVLTTLERRFNLQSADVGVIASSFEIGNLALILFVSYFGARGHRPRLIGCGGIVMALGA 120

Query: 121 LLSALPEFLTHQYKYEAGEIRWGAEGRDVCAANGSGGDEGPDPDLICRNRTATNMMYLLL 180
           LLSALPEFLTHQYKYEAGEIRWGAEGRDVCAANGSGGDEGPDPDLICRNRTATNMMYLLL
Sbjct: 121 LLSALPEFLTHQYKYEAGEIRWGAEGRDVCAANGSGGDEGPDPDLICRNRTATNMMYLLL 180

Query: 181 IGAQVLLGIGATPVQPLGVSYIDDHVRRKDSSLYIGILFTMLVFGPACGFILGSFCTKIY 240
           IGAQVLLGIGATPVQPLGVSYIDDHVRRKDSSLYIGILFTMLVFGPACGFILGSFCTKIY
Sbjct: 181 IGAQVLLGIGATPVQPLGVSYIDDHVRRKDSSLYIGILFTMLVFGPACGFILGSFCTKIY 240

Query: 241 VDAVFIDTSNLDITPDDPRWIGAWWGGFLLCGALLFFSSLLMFGFPQSLPPHSEPAMESE 300
           VDAVFIDTSNLDITPDDPRWIGAWWGGFLLCGALLFFSSLLMFGFPQSLPPHSEPAMESE
Sbjct: 241 VDAVFIDTSNLDITPDDPRWIGAWWGGFLLCGALLFFSSLLMFGFPQSLPPHSEPAMESE 300

Query: 301 QAMLSEREYERPKPSNGVLRHPLEPDSSASCFQQLRVIPKVTKHLLSNPVFTCIILAACM 360
           QAMLSEREYERPKPSNGVLRHPLEPDSSASCFQQLRVIPKVTKHLLSNPVFTCIILAACM
Sbjct: 301 QAMLSEREYERPKPSNGVLRHPLEPDSSASCFQQLRVIPKVTKHLLSNPVFTCIILAACM 360

Query: 361 EIAVVAGFAAFLGKYLEQQFNLTTSSANQLLGMTAIPCACLGIFLGGLLVKKLSLSALGA 420
           EIAVVAGFAAFLGKYLEQQFNLTTSSANQLLGMTAIPCACLGIFLGGLLVKKLSLSALGA
Sbjct: 361 EIAVVAGFAAFLGKYLEQQFNLTTSSANQLLGMTAIPCACLGIFLGGLLVKKLSLSALGA 420

Query: 421 IRMAMLVNLVSTACYVSFLFLGCDTGPVAGVTVPYGNSTAPGSALDPYSPCNNNCECQTD 480
           IRMAMLVNLVSTACYVSFLFLGCDTGPVAGVTVPYGNSTAPGSALDPYSPCNNNCECQTD
Sbjct: 421 IRMAMLVNLVSTACYVSFLFLGCDTGPVAGVTVPYGNSTAPGSALDPYSPCNNNCECQTD 480

Query: 481 SFTPVCGADGITYLSACFAGCNSTNLTGCACLTTVPAENATVVPGKCPSPGCQEAFLTFL 540
           SFTPVCGADGITYLSACFAGCNSTNLTGCACLTTVPAENATVVPGKCPSPGCQEAFLTFL
Sbjct: 481 SFTPVCGADGITYLSACFAGCNSTNLTGCACLTTVPAENATVVPGKCPSPGCQEAFLTFL 540

Query: 541 CVMCICSLIGAMAQTPSVIILIRTVSPELKSYALGVLFLLLRLLGFIPPPLIFGAGIDST 600
           CVMCICSLIGAMAQTPSVIILIRTVSPELKSYALGVLFLLLRLLGFIPPPLIFGAGIDST
Sbjct: 541 CVMCICSLIGAMAQTPSVIILIRTVSPELKSYALGVLFLLLRLLGFIPPPLIFGAGIDST 600

Query: 601 CLFWSTFCGEQGACVLYDNVVYRYLYVSIAIALKSFAFILYTTTWQCLRKNYKRYIKNHE 660
           CLFWSTFCGEQGACVLYDNVVYRYLYVSIAIALKSFAFILYTTTWQCLRKNYKRYIKNHE
Sbjct: 601 CLFWSTFCGEQGACVLYDNVVYRYLYVSIAIALKSFAFILYTTTWQCLRKNYKRYIKNHE 660

Query: 661 GGLSTSTEYQDIETEKTCPESHSPSEDSFVRS 692
           GGLSTSTEYQDIETEKTCPESHSPSEDSFVRS
Sbjct: 661 GGLSTSTEYQDIETEKTCPESHSPSEDSFVRS 692


>gi|222831575 solute carrier organic anion transporter family,
           member 3A1 isoform 1 [Homo sapiens]
          Length = 710

 Score = 1354 bits (3505), Expect = 0.0
 Identities = 666/666 (100%), Positives = 666/666 (100%)

Query: 1   MQGKKPGGSSGGGRSGELQGDEAQRNKKKKKKVSCFSNIKIFLVSECALMLAQGTVGAYL 60
           MQGKKPGGSSGGGRSGELQGDEAQRNKKKKKKVSCFSNIKIFLVSECALMLAQGTVGAYL
Sbjct: 1   MQGKKPGGSSGGGRSGELQGDEAQRNKKKKKKVSCFSNIKIFLVSECALMLAQGTVGAYL 60

Query: 61  VSVLTTLERRFNLQSADVGVIASSFEIGNLALILFVSYFGARGHRPRLIGCGGIVMALGA 120
           VSVLTTLERRFNLQSADVGVIASSFEIGNLALILFVSYFGARGHRPRLIGCGGIVMALGA
Sbjct: 61  VSVLTTLERRFNLQSADVGVIASSFEIGNLALILFVSYFGARGHRPRLIGCGGIVMALGA 120

Query: 121 LLSALPEFLTHQYKYEAGEIRWGAEGRDVCAANGSGGDEGPDPDLICRNRTATNMMYLLL 180
           LLSALPEFLTHQYKYEAGEIRWGAEGRDVCAANGSGGDEGPDPDLICRNRTATNMMYLLL
Sbjct: 121 LLSALPEFLTHQYKYEAGEIRWGAEGRDVCAANGSGGDEGPDPDLICRNRTATNMMYLLL 180

Query: 181 IGAQVLLGIGATPVQPLGVSYIDDHVRRKDSSLYIGILFTMLVFGPACGFILGSFCTKIY 240
           IGAQVLLGIGATPVQPLGVSYIDDHVRRKDSSLYIGILFTMLVFGPACGFILGSFCTKIY
Sbjct: 181 IGAQVLLGIGATPVQPLGVSYIDDHVRRKDSSLYIGILFTMLVFGPACGFILGSFCTKIY 240

Query: 241 VDAVFIDTSNLDITPDDPRWIGAWWGGFLLCGALLFFSSLLMFGFPQSLPPHSEPAMESE 300
           VDAVFIDTSNLDITPDDPRWIGAWWGGFLLCGALLFFSSLLMFGFPQSLPPHSEPAMESE
Sbjct: 241 VDAVFIDTSNLDITPDDPRWIGAWWGGFLLCGALLFFSSLLMFGFPQSLPPHSEPAMESE 300

Query: 301 QAMLSEREYERPKPSNGVLRHPLEPDSSASCFQQLRVIPKVTKHLLSNPVFTCIILAACM 360
           QAMLSEREYERPKPSNGVLRHPLEPDSSASCFQQLRVIPKVTKHLLSNPVFTCIILAACM
Sbjct: 301 QAMLSEREYERPKPSNGVLRHPLEPDSSASCFQQLRVIPKVTKHLLSNPVFTCIILAACM 360

Query: 361 EIAVVAGFAAFLGKYLEQQFNLTTSSANQLLGMTAIPCACLGIFLGGLLVKKLSLSALGA 420
           EIAVVAGFAAFLGKYLEQQFNLTTSSANQLLGMTAIPCACLGIFLGGLLVKKLSLSALGA
Sbjct: 361 EIAVVAGFAAFLGKYLEQQFNLTTSSANQLLGMTAIPCACLGIFLGGLLVKKLSLSALGA 420

Query: 421 IRMAMLVNLVSTACYVSFLFLGCDTGPVAGVTVPYGNSTAPGSALDPYSPCNNNCECQTD 480
           IRMAMLVNLVSTACYVSFLFLGCDTGPVAGVTVPYGNSTAPGSALDPYSPCNNNCECQTD
Sbjct: 421 IRMAMLVNLVSTACYVSFLFLGCDTGPVAGVTVPYGNSTAPGSALDPYSPCNNNCECQTD 480

Query: 481 SFTPVCGADGITYLSACFAGCNSTNLTGCACLTTVPAENATVVPGKCPSPGCQEAFLTFL 540
           SFTPVCGADGITYLSACFAGCNSTNLTGCACLTTVPAENATVVPGKCPSPGCQEAFLTFL
Sbjct: 481 SFTPVCGADGITYLSACFAGCNSTNLTGCACLTTVPAENATVVPGKCPSPGCQEAFLTFL 540

Query: 541 CVMCICSLIGAMAQTPSVIILIRTVSPELKSYALGVLFLLLRLLGFIPPPLIFGAGIDST 600
           CVMCICSLIGAMAQTPSVIILIRTVSPELKSYALGVLFLLLRLLGFIPPPLIFGAGIDST
Sbjct: 541 CVMCICSLIGAMAQTPSVIILIRTVSPELKSYALGVLFLLLRLLGFIPPPLIFGAGIDST 600

Query: 601 CLFWSTFCGEQGACVLYDNVVYRYLYVSIAIALKSFAFILYTTTWQCLRKNYKRYIKNHE 660
           CLFWSTFCGEQGACVLYDNVVYRYLYVSIAIALKSFAFILYTTTWQCLRKNYKRYIKNHE
Sbjct: 601 CLFWSTFCGEQGACVLYDNVVYRYLYVSIAIALKSFAFILYTTTWQCLRKNYKRYIKNHE 660

Query: 661 GGLSTS 666
           GGLSTS
Sbjct: 661 GGLSTS 666


>gi|8394291 solute carrier organic anion transporter family, member
           1C1 isoform 2 [Homo sapiens]
          Length = 712

 Score =  414 bits (1065), Expect = e-115
 Identities = 225/654 (34%), Positives = 366/654 (55%), Gaps = 49/654 (7%)

Query: 30  KKKVSCFSNIKIFLVSECALMLAQGTVGAYLVSVLTTLERRFNLQSADVGVIASSFEIGN 89
           ++K  C   +K+FL +   +  A+     YL S +T +ERRF++ S+ VGVI  SFEIGN
Sbjct: 33  EEKQPCCGELKVFLCALSFVYFAKALAEGYLKSTITQIERRFDIPSSLVGVIDGSFEIGN 92

Query: 90  LALILFVSYFGARGHRPRLIGCGGIVMALGALLSALPEFLTHQYKYEAGEIRWGAEGRDV 149
           L +I FVSYFGA+ HRP++IG G ++M +G LL A+P+F   QYKYE    R+       
Sbjct: 93  LLVITFVSYFGAKLHRPKIIGAGCVIMGVGTLLIAMPQFFMEQYKYE----RYSPSSNST 148

Query: 150 CAANGSGGDEGPDPDLI------------CRNRTATNMMYLLLIGAQVLLGIGATPVQPL 197
            + +    +      +             C   T+++M   + +G  +L GIG TP+QPL
Sbjct: 149 LSISPCLLESSSQLPVSVMEKSKSKISNECEVDTSSSMWIYVFLG-NLLRGIGETPIQPL 207

Query: 198 GVSYIDDHVRRKDSSLYIGILFTMLVFGPACGFILGSFCTKIYVDAVFIDTSNLDITPDD 257
           G++Y+DD     +++ YIG + T+ + GP  GF+LGS C K+YVD  F++  ++ ITP D
Sbjct: 208 GIAYLDDFASEDNAAFYIGCVQTVAIIGPIFGFLLGSLCAKLYVDIGFVNLDHITITPKD 267

Query: 258 PRWIGAWWGGFLLCGALLFFSSLLMFGFPQSLP-----PHSEPAMESEQAMLSER-EYER 311
           P+W+GAWW G+L+ G +   +++  +  P+SLP       S  + E  + ++ +  +Y+ 
Sbjct: 268 PQWVGAWWLGYLIAGIISLLAAVPFWYLPKSLPRSQSREDSNSSSEKSKFIIDDHTDYQT 327

Query: 312 PKPSNGVLRHPLEPDSSASCFQQLRVIPKVTKHLLSNPVFTCIILAACMEIAVVAGFAAF 371
           P+  N            A   +  R      K+L  NPV+   +  + ++   + G   +
Sbjct: 328 PQGEN------------AKIMEMARDFLPSLKNLFGNPVYFLYLCTSTVQFNSLFGMVTY 375

Query: 372 LGKYLEQQFNLTTSSANQLLGMTAIPCACLGIFLGGLLVKKLSLSALGAIRMAMLVNLVS 431
             KY+EQQ+  ++S AN ++G+  IP   LGIF GG+++KK  +S  GA ++ +  ++  
Sbjct: 376 KPKYIEQQYGQSSSRANFVIGLINIPAVALGIFSGGIVMKKFRISVCGAAKLYLGSSVFG 435

Query: 432 TACYVSFLFLGCDTGPVAGVTVPYGNSTAPGSALDP--YSPCNNNCECQTDSFTPVCGAD 489
              ++S   LGC+   VAG+TV Y   T P S  +   +S CN+ C+C    + P+CG +
Sbjct: 436 YLLFLSLFALGCENSDVAGLTVSY-QGTKPVSYHERALFSDCNSRCKCSETKWEPMCGEN 494

Query: 490 GITYLSACFAGCNSTNLTG-------CACLTTVPAE--NATVVPGKCPSP-GCQEAFLTF 539
           GITY+SAC AGC ++N +G       C C+    ++  N++ + G+C    GC + FL F
Sbjct: 495 GITYVSACLAGCQTSNRSGKNIIFYNCTCVGIAASKSGNSSGIVGRCQKDNGCPQMFLYF 554

Query: 540 LCVMCICSLIGAMAQTPSVIILIRTVSPELKSYALGVLFLLLRLLGFIPPPLIFGAGIDS 599
           L +  I S   ++   P  I+L+R + P+LKS+ALG+  L +R+L  IP P+ FG  ID+
Sbjct: 555 LVISVITSYTLSLGGIPGYILLLRCIKPQLKSFALGIYTLAIRVLAGIPAPVYFGVLIDT 614

Query: 600 TCLFWS-TFCGEQGACVLYDNVVYRYLYVSIAIALKSFAFILYTTTWQCLRKNY 652
           +CL W    CG +G+C LYD+ V+R++Y+ + + L + + +L       L+KNY
Sbjct: 615 SCLKWGFKRCGSRGSCRLYDSNVFRHIYLGLTVILGTVSILLSIAVLFILKKNY 668


>gi|188528663 solute carrier organic anion transporter family,
           member 2A1 [Homo sapiens]
          Length = 643

 Score =  412 bits (1060), Expect = e-115
 Identities = 240/665 (36%), Positives = 358/665 (53%), Gaps = 47/665 (7%)

Query: 16  GELQGDEAQRNKKKKKKVSCFSNIKIFLVSECALMLAQGTVGAYLVSVLTTLERRFNLQS 75
           G  QG +   ++  +   S F NIK+F++ +  L L Q    AY  S LTT+E+RF L S
Sbjct: 8   GASQGSDTSTSRAGRCARSVFGNIKVFVLCQGLLQLCQLLYSAYFKSSLTTIEKRFGLSS 67

Query: 76  ADVGVIASSFEIGNLALILFVSYFGARGHRPRLIGCGGIVMALGALLSALPEFLTHQYKY 135
           +  G+I+S  EI N  LI+FVSYFG+R HRPRLIG GG+ +A GA +  LP FL+  Y+Y
Sbjct: 68  SSSGLISSLNEISNAILIIFVSYFGSRVHRPRLIGIGGLFLAAGAFILTLPHFLSEPYQY 127

Query: 136 EAGEIRWGAEGR---DVCAANGSGGDEGPDPDLICRNRTATNMMYLLLIGAQVLLGIGAT 192
                  G   R   ++C  +                +  T+ M+ L++ AQ+L GIG  
Sbjct: 128 TLAST--GNNSRLQAELCQKHWQDLPPSKCHSTTQNPQKETSSMWGLMVVAQLLAGIGTV 185

Query: 193 PVQPLGVSYIDDHVRRKDSSLYIGILFTMLVFGPACGFILGSFCTKIYVDAVFIDTSNLD 252
           P+QP G+SY+DD     +S LYI ILF + VFGPA G++LGS   +I+VD   ++T+ ++
Sbjct: 186 PIQPFGISYVDDFSEPSNSPLYISILFAISVFGPAFGYLLGSVMLQIFVDYGRVNTAAVN 245

Query: 253 ITPDDPRWIGAWWGGFLLCGALLFFSSLLMFGFPQSLPPHSE--PAMESEQAMLSEREYE 310
           + P DPRWIGAWW G L+  ALL  +S   F FP+++P  ++  PA   E   L E +  
Sbjct: 246 LVPGDPRWIGAWWLGLLISSALLVLTSFPFFFFPRAMPIGAKRAPATADEARKLEEAK-- 303

Query: 311 RPKPSNGVLRHPLEPDSSASCFQQLRVIPKVTKHLLSNPVFTCIILAACMEIAVVAGFAA 370
                           S  S    ++  P +   LL N +F  ++LA C   +V+AG + 
Sbjct: 304 ----------------SRGSLVDFIKRFPCIFLRLLMNSLFVLVVLAQCTFSSVIAGLST 347

Query: 371 FLGKYLEQQFNLTTSSANQLLGMTAIPCACLGIFLGGLLVKKLSLSALGAIRMAMLVNLV 430
           FL K+LE+Q+  + + AN L+G   +P A LG+  GG+L+K+   S     R+A  +  +
Sbjct: 348 FLNKFLEKQYGTSAAYANFLIGAVNLPAAALGMLFGGILMKRFVFSLQAIPRIATTIITI 407

Query: 431 STACYVSFLFLGCDTGPVAGVTVPYGNSTAPGSALDPYSP-CNNNCECQTDSFTPVCGAD 489
           S    V   F+GC T  VA V  P     +  S++ P SP C  +C C    F PVCG +
Sbjct: 408 SMILCVPLFFMGCSTPTVAEVYPP-----STSSSIHPQSPACRRDCSCPDSIFHPVCGDN 462

Query: 490 GITYLSACFAGCNSTNLT----------GCACLTTVPAENATVVPGKCPSPGCQEAFLTF 539
           GI YLS C AGC++ N++           C+C+T     +A+   G CP P C    L  
Sbjct: 463 GIEYLSPCHAGCSNINMSSATSKQLIYLNCSCVT---GGSASAKTGSCPVP-CAHFLLPA 518

Query: 540 LCVMCICSLIGAMAQTPSVIILIRTVSPELKSYALGVLFLLLRLLGFIPPPLIFGAGIDS 599
           + ++   SLI  ++  P  ++++R V+ E KS+A+GV FLL+RLL ++P P ++G  ID 
Sbjct: 519 IFLISFVSLIACISHNPLYMMVLRVVNQEEKSFAIGVQFLLMRLLAWLPSPALYGLTIDH 578

Query: 600 TCLFWSTFC-GEQGACVLYDNVVYRYLYVSIAIALKSFAFILYTTTWQCLRKNYKRYIKN 658
           +C+ W++ C G +GAC  YDN   R  Y+ + +  K+   +L       ++KN K Y   
Sbjct: 579 SCIRWNSLCLGRRGACAYYDNDALRDRYLGLQMGYKALGMLLLCFISWRVKKN-KEYNVQ 637

Query: 659 HEGGL 663
              GL
Sbjct: 638 KAAGL 642


>gi|225543118 solute carrier organic anion transporter family,
           member 1C1 isoform 1 [Homo sapiens]
          Length = 730

 Score =  403 bits (1035), Expect = e-112
 Identities = 221/631 (35%), Positives = 353/631 (55%), Gaps = 49/631 (7%)

Query: 30  KKKVSCFSNIKIFLVSECALMLAQGTVGAYLVSVLTTLERRFNLQSADVGVIASSFEIGN 89
           ++K  C   +K+FL +   +  A+     YL S +T +ERRF++ S+ VGVI  SFEIGN
Sbjct: 33  EEKQPCCGELKVFLCALSFVYFAKALAEGYLKSTITQIERRFDIPSSLVGVIDGSFEIGN 92

Query: 90  LALILFVSYFGARGHRPRLIGCGGIVMALGALLSALPEFLTHQYKYEAGEIRWGAEGRDV 149
           L +I FVSYFGA+ HRP++IG G ++M +G LL A+P+F   QYKYE    R+       
Sbjct: 93  LLVITFVSYFGAKLHRPKIIGAGCVIMGVGTLLIAMPQFFMEQYKYE----RYSPSSNST 148

Query: 150 CAANGSGGDEGPDPDLI------------CRNRTATNMMYLLLIGAQVLLGIGATPVQPL 197
            + +    +      +             C   T+++M   + +G  +L GIG TP+QPL
Sbjct: 149 LSISPCLLESSSQLPVSVMEKSKSKISNECEVDTSSSMWIYVFLG-NLLRGIGETPIQPL 207

Query: 198 GVSYIDDHVRRKDSSLYIGILFTMLVFGPACGFILGSFCTKIYVDAVFIDTSNLDITPDD 257
           G++Y+DD     +++ YIG + T+ + GP  GF+LGS C K+YVD  F++  ++ ITP D
Sbjct: 208 GIAYLDDFASEDNAAFYIGCVQTVAIIGPIFGFLLGSLCAKLYVDIGFVNLDHITITPKD 267

Query: 258 PRWIGAWWGGFLLCGALLFFSSLLMFGFPQSLP-----PHSEPAMESEQAMLSER-EYER 311
           P+W+GAWW G+L+ G +   +++  +  P+SLP       S  + E  + ++ +  +Y+ 
Sbjct: 268 PQWVGAWWLGYLIAGIISLLAAVPFWYLPKSLPRSQSREDSNSSSEKSKFIIDDHTDYQT 327

Query: 312 PKPSNGVLRHPLEPDSSASCFQQLRVIPKVTKHLLSNPVFTCIILAACMEIAVVAGFAAF 371
           P+  N            A   +  R      K+L  NPV+   +  + ++   + G   +
Sbjct: 328 PQGEN------------AKIMEMARDFLPSLKNLFGNPVYFLYLCTSTVQFNSLFGMVTY 375

Query: 372 LGKYLEQQFNLTTSSANQLLGMTAIPCACLGIFLGGLLVKKLSLSALGAIRMAMLVNLVS 431
             KY+EQQ+  ++S AN ++G+  IP   LGIF GG+++KK  +S  GA ++ +  ++  
Sbjct: 376 KPKYIEQQYGQSSSRANFVIGLINIPAVALGIFSGGIVMKKFRISVCGAAKLYLGSSVFG 435

Query: 432 TACYVSFLFLGCDTGPVAGVTVPYGNSTAPGSALDP--YSPCNNNCECQTDSFTPVCGAD 489
              ++S   LGC+   VAG+TV Y   T P S  +   +S CN+ C+C    + P+CG +
Sbjct: 436 YLLFLSLFALGCENSDVAGLTVSY-QGTKPVSYHERALFSDCNSRCKCSETKWEPMCGEN 494

Query: 490 GITYLSACFAGCNSTNLTG-------CACLTTVPAE--NATVVPGKCPSP-GCQEAFLTF 539
           GITY+SAC AGC ++N +G       C C+    ++  N++ + G+C    GC + FL F
Sbjct: 495 GITYVSACLAGCQTSNRSGKNIIFYNCTCVGIAASKSGNSSGIVGRCQKDNGCPQMFLYF 554

Query: 540 LCVMCICSLIGAMAQTPSVIILIRTVSPELKSYALGVLFLLLRLLGFIPPPLIFGAGIDS 599
           L +  I S   ++   P  I+L+R + P+LKS+ALG+  L +R+L  IP P+ FG  ID+
Sbjct: 555 LVISVITSYTLSLGGIPGYILLLRCIKPQLKSFALGIYTLAIRVLAGIPAPVYFGVLIDT 614

Query: 600 TCLFWS-TFCGEQGACVLYDNVVYRYLYVSI 629
           +CL W    CG +G+C LYD+ V+RY   SI
Sbjct: 615 SCLKWGFKRCGSRGSCRLYDSNVFRYQIKSI 645


>gi|225637473 solute carrier organic anion transporter family,
           member 5A1 isoform 1 [Homo sapiens]
          Length = 848

 Score =  397 bits (1021), Expect = e-110
 Identities = 235/689 (34%), Positives = 369/689 (53%), Gaps = 55/689 (7%)

Query: 40  KIFLVSECALMLAQGT-VGAYLVSVLTTLERRFNLQSADVGVIASSFEIGNLALILFVSY 98
           + FLV  C L   Q   V  YL SV+TT+ERR++L+S++ G++ S F+IGNL +++FVSY
Sbjct: 128 RCFLVCMCFLTFIQALMVSGYLSSVITTIERRYSLKSSESGLLVSCFDIGNLVVVVFVSY 187

Query: 99  FGARGHRPRLIGCGGIVMALGALLSALPEFLTHQYKYEAGEIRWGAEGRDVCAANGSGGD 158
           FG RG RP  +  GG+++A GA L ALP F++  Y+ +  E+   A    +C    S   
Sbjct: 188 FGGRGRRPLWLAVGGLLIAFGAALFALPHFISPPYQIQ--ELNASAPNDGLCQGGNSTAT 245

Query: 159 EGPDPDLICRNRTATNMMYL---LLIGAQVLLGIGATPVQPLGVSYIDDHVRRKDSSLYI 215
             P     C   +  N  ++   L I AQ+L+G+G+TP+  LG +Y+DD+V++++SSLY+
Sbjct: 246 LEPPA---CPKDSGGNNHWVYVALFICAQILIGMGSTPIYTLGPTYLDDNVKKENSSLYL 302

Query: 216 GILFTMLVFGPACGFILGSFCTKIYVDAVFIDTSNLDITPDDPRWIGAWWGGFLLCGALL 275
            I++ M   GPA G++LG      YVD      + + +  +DPR+IG WW GFLLC   +
Sbjct: 303 AIMYVMGALGPAVGYLLGGLLIGFYVDP----RNPVHLDQNDPRFIGNWWSGFLLCAIAM 358

Query: 276 FFSSLLMFGFPQSLPPHSEPAMESEQAMLSEREYERPKPSNGVLRHPLEPDSSASCFQQL 335
           F     MF FP+ LPP  +   + + ++ +  + +  K  +       +  SS    + +
Sbjct: 359 FLVIFPMFTFPKKLPPRHKKKKKKKFSVDAVSDDDVLKEKSNNSEQADKKVSSMGFGKDV 418

Query: 336 RVIPKVTKHLLSNPVFTCIILAACMEIAVVAGFAAFLGKYLEQQFNLTTSSANQLLGMTA 395
           R +P+    +LSN  F  + L+   E A+V  F  F+ K++E QF +  S+A+   G+  
Sbjct: 419 RDLPRAAVRILSNMTFLFVSLSYTAESAIVTAFITFIPKFIESQFGIPASNASIYTGVII 478

Query: 396 IPCACLGIFLGGLLVKKLSLSALGAIRMAMLVNLVSTACYVSFLFLGCDTGPVAGVTVPY 455
           +P A +GI LGG ++KKL L A  + ++AM+ + VS  C+ +   +GC++  + G+ +PY
Sbjct: 479 VPSAGVGIVLGGYIIKKLKLGARESAKLAMICSGVSLLCFSTLFIVGCESINLGGINIPY 538

Query: 456 GNSTAPGSALDPYS---PCNNNCECQTDSFTPVCGADGITYLSACFAGC-NSTNL----- 506
             +T P   +   +    CN NC C+   + PVCG+DGITY + C AGC NS NL     
Sbjct: 539 --TTGPSLTMPHRNLTGSCNVNCGCKIHEYEPVCGSDGITYFNPCLAGCVNSGNLSTGIR 596

Query: 507 --TGCACLT----------------------TVPAENATVVPGKCPSPGCQEAFLTFLCV 542
             T C C+                       T   EN   V GKC    C    + FL  
Sbjct: 597 NYTECTCVQSRQVITPPTVGQRSQLRVVIVKTYLNENGYAVSGKCKRT-CN-TLIPFLVF 654

Query: 543 MCICSLIGAMAQTPSVIILIRTVSPELKSYALGVLFLLLRLLGFIPPPLIFGAGIDSTCL 602
           + I + I A AQ  ++I+ +R+V  E + +ALG+ F+LLR L +IP P+ FGA ID+TC+
Sbjct: 655 LFIVTFITACAQPSAIIVTLRSVEDEERPFALGMQFVLLRTLAYIPTPIYFGAVIDTTCM 714

Query: 603 FWSTFCGEQGACVLYDNVVYRYLYVSIAIALKSFAFILYTTTWQCL--RKNYKRYIKNHE 660
            W   CG QG+C  Y+   +R++Y  +A  LK   FI     W  +  +++  +  +  E
Sbjct: 715 LWQQECGVQGSCWEYNVTSFRFVYFGLAAGLKFVGFIFIFLAWYSIKYKEDGLQRRRQRE 774

Query: 661 GGLSTSTE---YQDIETEKTCPESHSPSE 686
             LST +E   + D    ++CP   +  E
Sbjct: 775 FPLSTVSERVGHPDNARTRSCPAFSTQGE 803


>gi|9790233 solute carrier organic anion transporter family, member
           1B3 [Homo sapiens]
          Length = 702

 Score =  395 bits (1016), Expect = e-110
 Identities = 226/651 (34%), Positives = 355/651 (54%), Gaps = 29/651 (4%)

Query: 23  AQRNKKKKKKVSCFSNIKIFLVSECALMLAQGTVGAYLVSVLTTLERRFNLQSADVGVIA 82
           A+    +KKK    +  K+FL +     +A+   G  +   +T +ERRF++ S+  G+I 
Sbjct: 11  AESASSEKKKTRRCNGFKMFLAALSFSYIAKALGGIIMKISITQIERRFDISSSLAGLID 70

Query: 83  SSFEIGNLALILFVSYFGARGHRPRLIGCGGIVMALGALLSALPEFLTHQYKYEA----G 138
            SFEIGNL +I+FVSYFG++ HRP+LIG G ++M  G++L++LP F    Y+Y       
Sbjct: 71  GSFEIGNLLVIVFVSYFGSKLHRPKLIGIGCLLMGTGSILTSLPHFFMGYYRYSKETHIN 130

Query: 139 EIRWGAEGRDVCAANGSGGDEGPDPDLI---CRNRTATNMMYLLLIGAQVLLGIGATPVQ 195
                      C  N +    G  P+++   C   + ++M   + +G  +L GIG TP+ 
Sbjct: 131 PSENSTSSLSTCLINQTLSFNGTSPEIVEKDCVKESGSHMWIYVFMG-NMLRGIGETPIV 189

Query: 196 PLGVSYIDDHVRRKDSSLYIGILFTMLVFGPACGFILGSFCTKIYVDAVFIDTSNLDITP 255
           PLG+SYIDD  +   SSLY+G L  + + GP  GF LGS   K+YVD  ++D S + ITP
Sbjct: 190 PLGISYIDDFAKEGHSSLYLGSLNAIGMIGPVIGFALGSLFAKMYVDIGYVDLSTIRITP 249

Query: 256 DDPRWIGAWWGGFLLCGALLFFSSLLMFGFPQS-LPPHSEPAMESEQAMLSEREYERPKP 314
            D RW+GAWW GFL+ G     SS+  F  P++   P  E  +     +L   + +R + 
Sbjct: 250 KDSRWVGAWWLGFLVSGLFSIISSIPFFFLPKNPNKPQKERKISLSLHVLKTND-DRNQT 308

Query: 315 SNGVLRHPLEPDSSASCFQQLRVIPKVTKHLLSNPVFTCIILAACMEIAVVAGFAAFLGK 374
           +N   +      +    FQ L       K +L+NP++   +L   ++++   G   ++ K
Sbjct: 309 ANLTNQGKNVTKNVTGFFQSL-------KSILTNPLYVIFLLLTLLQVSSFIGSFTYVFK 361

Query: 375 YLEQQFNLTTSSANQLLGMTAIPCACLGIFLGGLLVKKLSLSALGAIRMAMLVNLVSTAC 434
           Y+EQQ+  + S AN LLG+  IP    G+FLGG ++KK  LS +G  + + L +++S   
Sbjct: 362 YMEQQYGQSASHANFLLGIITIPTVATGMFLGGFIIKKFKLSLVGIAKFSFLTSMISFLF 421

Query: 435 YVSFLFLGCDTGPVAGVTVPYGNSTAPGSALD-PYSPCNNNCECQTDSFTPVCGADGITY 493
            + +  L C++  VAG+T+ Y  + +  S +D P S CN+ C C    + PVCG +GITY
Sbjct: 422 QLLYFPLICESKSVAGLTLTYDGNNSVASHVDVPLSYCNSECNCDESQWEPVCGNNGITY 481

Query: 494 LSACFAGCNS-------TNLTGCAC--LTTVPAENATVVPGKCPSPG-CQEAFLTFLCVM 543
           LS C AGC S       T    C+C  +T +   N +   G+CP    C   F  ++ + 
Sbjct: 482 LSPCLAGCKSSSGIKKHTVFYNCSCVEVTGLQNRNYSAHLGECPRDNTCTRKFFIYVAIQ 541

Query: 544 CICSLIGAMAQTPSVIILIRTVSPELKSYALGVLFLLLRLLGFIPPPLIFGAGIDSTCLF 603
            I SL  A   T  +++ ++ V PELK+ A+G   +++R LG I  P+ FGA ID TC+ 
Sbjct: 542 VINSLFSATGGTTFILLTVKIVQPELKALAMGFQSMVIRTLGGILAPIYFGALIDKTCMK 601

Query: 604 WST-FCGEQGACVLYDNVVYRYLYVSIAIALKSFAFILYTTTWQCLRKNYK 653
           WST  CG QGAC +Y++V +  +Y+ ++IAL+  A +LY      ++K ++
Sbjct: 602 WSTNSCGAQGACRIYNSVFFGRVYLGLSIALRFPALVLYIVFIFAMKKKFQ 652


>gi|10835099 organic anion transporting polypeptide A [Homo sapiens]
          Length = 670

 Score =  391 bits (1004), Expect = e-108
 Identities = 213/620 (34%), Positives = 343/620 (55%), Gaps = 29/620 (4%)

Query: 32  KVSCFSNIKIFLVSECALMLAQGTVGAYLVSVLTTLERRFNLQSADVGVIASSFEIGNLA 91
           ++ C S +K+FL++     +++   G+Y+ S+LT +ER+FN+ ++ VG I  SFEIGNL 
Sbjct: 12  RIRCLSKLKMFLLAITCAFVSKTLSGSYMNSMLTQIERQFNIPTSLVGFINGSFEIGNLL 71

Query: 92  LILFVSYFGARGHRPRLIGCGGIVMALGALLSALPEFLTHQYKYEAGEIRWG--AEGRDV 149
           LI+FVSYFG + HRP +IG G +VM LG  L +LP FL +QY+YE+     G  +    +
Sbjct: 72  LIIFVSYFGTKLHRPIMIGIGCVVMGLGCFLKSLPHFLMNQYEYESTVSVSGNLSSNSFL 131

Query: 150 CAANGSGGDEGPDPDLICRNRTATNMMYLLLIGAQVLLGIGATPVQPLGVSYIDDHVRRK 209
           C  NG+           C     + M   +L+G  ++ G+G TP+ PLG+SYI+D  + +
Sbjct: 132 CMENGTQILRPTQDPSECTKEVKSLMWVYVLVG-NIVRGMGETPILPLGISYIEDFAKFE 190

Query: 210 DSSLYIGILFTMLVFGPACGFILGSFCTKIYVDAVFIDTSNLDITPDDPRWIGAWWGGFL 269
           +S LYIG++ T  + GP  G +L SFC  +YVD  F++T +L ITP D RW+GAWW GFL
Sbjct: 191 NSPLYIGLVETGAIIGPLIGLLLASFCANVYVDTGFVNTDDLIITPTDTRWVGAWWFGFL 250

Query: 270 LCGALLFFSSLLMFGFPQSLPPHSEPAMESEQAMLSEREYERPKPSNGVLRHPLEPDSSA 329
           +C  +   +++  F  P +LP   +  +E+   ++     ++ K      ++ +  D   
Sbjct: 251 ICAGVNVLTAIPFFFLPNTLP---KEGLETNADIIKNENEDKQKEEVKKEKYGITKD--- 304

Query: 330 SCFQQLRVIPKVTKHLLSNPVFTCIILAACMEIAVVAGFAAFLGKYLEQQFNLTTSSANQ 389
                   +P   K L  NP++   IL + ++        +F+ KYLEQQ+ +++S A  
Sbjct: 305 -------FLP-FMKSLSCNPIYMLFILVSVIQFNAFVNMISFMPKYLEQQYGISSSDAIF 356

Query: 390 LLGMTAIPCACLGIFLGGLLVKKLSLSALGAIRMAMLVNLVSTACYVSFLFLGCDTGPVA 449
           L+G+  +P  C+G  +GGL++KK  ++   A  +   ++L+    Y     + C+   V 
Sbjct: 357 LMGIYNLPPICIGYIIGGLIMKKFKITVKQAAHIGCWLSLLEYLLYFLSFLMTCENSSVV 416

Query: 450 GVTVPY-GNSTAPGSALDPYSPCNNNCECQTDSFTPVCGADGITYLSACFAGCNSTNLTG 508
           G+   Y G         D ++ CN +C C +  + PVCG +G++YLSAC AGC ++  TG
Sbjct: 417 GINTSYEGIPQDLYVENDIFADCNVDCNCPSKIWDPVCGNNGLSYLSACLAGCETSIGTG 476

Query: 509 -------CACLTTVPAENATVVPGKC-PSPGCQEAFLTFLCVMCICSLIGAMAQTPSVII 560
                  C+C+ T  + N++ V G C   P C      FL +  + S I ++A  P  ++
Sbjct: 477 INMVFQNCSCIQT--SGNSSAVLGLCDKGPDCSLMLQYFLILSAMSSFIYSLAAIPGYMV 534

Query: 561 LIRTVSPELKSYALGVLFLLLRLLGFIPPPLIFGAGIDSTCLFWSTF-CGEQGACVLYDN 619
           L+R +  E KS  +G+     R+   IP P+ FGA +DSTCL W T  CGE GAC +YD+
Sbjct: 535 LLRCMKSEEKSLGVGLHTFCTRVFAGIPAPIYFGALMDSTCLHWGTLKCGESGACRIYDS 594

Query: 620 VVYRYLYVSIAIALKSFAFI 639
             +RY+Y+ +  AL+  +F+
Sbjct: 595 TTFRYIYLGLPAALRGSSFV 614


>gi|19913403 organic anion transporting polypeptide A [Homo sapiens]
          Length = 670

 Score =  391 bits (1004), Expect = e-108
 Identities = 213/620 (34%), Positives = 343/620 (55%), Gaps = 29/620 (4%)

Query: 32  KVSCFSNIKIFLVSECALMLAQGTVGAYLVSVLTTLERRFNLQSADVGVIASSFEIGNLA 91
           ++ C S +K+FL++     +++   G+Y+ S+LT +ER+FN+ ++ VG I  SFEIGNL 
Sbjct: 12  RIRCLSKLKMFLLAITCAFVSKTLSGSYMNSMLTQIERQFNIPTSLVGFINGSFEIGNLL 71

Query: 92  LILFVSYFGARGHRPRLIGCGGIVMALGALLSALPEFLTHQYKYEAGEIRWG--AEGRDV 149
           LI+FVSYFG + HRP +IG G +VM LG  L +LP FL +QY+YE+     G  +    +
Sbjct: 72  LIIFVSYFGTKLHRPIMIGIGCVVMGLGCFLKSLPHFLMNQYEYESTVSVSGNLSSNSFL 131

Query: 150 CAANGSGGDEGPDPDLICRNRTATNMMYLLLIGAQVLLGIGATPVQPLGVSYIDDHVRRK 209
           C  NG+           C     + M   +L+G  ++ G+G TP+ PLG+SYI+D  + +
Sbjct: 132 CMENGTQILRPTQDPSECTKEVKSLMWVYVLVG-NIVRGMGETPILPLGISYIEDFAKFE 190

Query: 210 DSSLYIGILFTMLVFGPACGFILGSFCTKIYVDAVFIDTSNLDITPDDPRWIGAWWGGFL 269
           +S LYIG++ T  + GP  G +L SFC  +YVD  F++T +L ITP D RW+GAWW GFL
Sbjct: 191 NSPLYIGLVETGAIIGPLIGLLLASFCANVYVDTGFVNTDDLIITPTDTRWVGAWWFGFL 250

Query: 270 LCGALLFFSSLLMFGFPQSLPPHSEPAMESEQAMLSEREYERPKPSNGVLRHPLEPDSSA 329
           +C  +   +++  F  P +LP   +  +E+   ++     ++ K      ++ +  D   
Sbjct: 251 ICAGVNVLTAIPFFFLPNTLP---KEGLETNADIIKNENEDKQKEEVKKEKYGITKD--- 304

Query: 330 SCFQQLRVIPKVTKHLLSNPVFTCIILAACMEIAVVAGFAAFLGKYLEQQFNLTTSSANQ 389
                   +P   K L  NP++   IL + ++        +F+ KYLEQQ+ +++S A  
Sbjct: 305 -------FLP-FMKSLSCNPIYMLFILVSVIQFNAFVNMISFMPKYLEQQYGISSSDAIF 356

Query: 390 LLGMTAIPCACLGIFLGGLLVKKLSLSALGAIRMAMLVNLVSTACYVSFLFLGCDTGPVA 449
           L+G+  +P  C+G  +GGL++KK  ++   A  +   ++L+    Y     + C+   V 
Sbjct: 357 LMGIYNLPPICIGYIIGGLIMKKFKITVKQAAHIGCWLSLLEYLLYFLSFLMTCENSSVV 416

Query: 450 GVTVPY-GNSTAPGSALDPYSPCNNNCECQTDSFTPVCGADGITYLSACFAGCNSTNLTG 508
           G+   Y G         D ++ CN +C C +  + PVCG +G++YLSAC AGC ++  TG
Sbjct: 417 GINTSYEGIPQDLYVENDIFADCNVDCNCPSKIWDPVCGNNGLSYLSACLAGCETSIGTG 476

Query: 509 -------CACLTTVPAENATVVPGKC-PSPGCQEAFLTFLCVMCICSLIGAMAQTPSVII 560
                  C+C+ T  + N++ V G C   P C      FL +  + S I ++A  P  ++
Sbjct: 477 INMVFQNCSCIQT--SGNSSAVLGLCDKGPDCSLMLQYFLILSAMSSFIYSLAAIPGYMV 534

Query: 561 LIRTVSPELKSYALGVLFLLLRLLGFIPPPLIFGAGIDSTCLFWSTF-CGEQGACVLYDN 619
           L+R +  E KS  +G+     R+   IP P+ FGA +DSTCL W T  CGE GAC +YD+
Sbjct: 535 LLRCMKSEEKSLGVGLHTFCTRVFAGIPAPIYFGALMDSTCLHWGTLKCGESGACRIYDS 594

Query: 620 VVYRYLYVSIAIALKSFAFI 639
             +RY+Y+ +  AL+  +F+
Sbjct: 595 TTFRYIYLGLPAALRGSSFV 614


>gi|225543525 solute carrier organic anion transporter family,
           member 1B1 [Homo sapiens]
          Length = 691

 Score =  385 bits (990), Expect = e-107
 Identities = 227/657 (34%), Positives = 360/657 (54%), Gaps = 41/657 (6%)

Query: 23  AQRNKKKKKKVSCFSNIKIFLVSECALMLAQGTVGAYLV-SVLTTLERRFNLQSADVGVI 81
           A+    + KK    + +K+FL +     +A+ T+GA ++ S +  +ERRF + S+ VG I
Sbjct: 11  AEAQPSENKKTRYCNGLKMFLAALSLSFIAK-TLGAIIMKSSIIHIERRFEISSSLVGFI 69

Query: 82  ASSFEIGNLALILFVSYFGARGHRPRLIGCGGIVMALGALLSALPEFLTHQYKYEAGEIR 141
             SFEIGNL +I+FVSYFG++ HRP+LIG G  +M +G +L+ALP F    Y+Y      
Sbjct: 70  DGSFEIGNLLVIVFVSYFGSKLHRPKLIGIGCFIMGIGGVLTALPHFFMGYYRYSKETNI 129

Query: 142 WGAEGR----DVCAANGSGGDEGPDPDLICRN--RTATNMMYLLLIGAQVLLGIGATPVQ 195
             +E        C  N         P+++ +   + + + M++ +    +L GIG TP+ 
Sbjct: 130 NSSENSTSTLSTCLINQILSLNRASPEIVGKGCLKESGSYMWIYVFMGNMLRGIGETPIV 189

Query: 196 PLGVSYIDDHVRRKDSSLYIGILFTMLVFGPACGFILGSFCTKIYVDAVFIDTSNLDITP 255
           PLG+SYIDD  +   SSLY+GIL  + + GP  GF LGS  +K+YVD  ++D S + ITP
Sbjct: 190 PLGLSYIDDFAKEGHSSLYLGILNAIAMIGPIIGFTLGSLFSKMYVDIGYVDLSTIRITP 249

Query: 256 DDPRWIGAWWGGFLLCGALLFFSSLLMFGFPQSLPPHSEPAMESEQAMLSEREYERPKPS 315
            D RW+GAWW  FL+ G     SS+  F  PQ+    ++P  E + ++           S
Sbjct: 250 TDSRWVGAWWLNFLVSGLFSIISSIPFFFLPQT---PNKPQKERKASL-----------S 295

Query: 316 NGVLRHPLEPDSSASCFQQLRVIPK-VT------KHLLSNPVFTCIILAACMEIAVVAGF 368
             VL    E D +A+   Q + I K VT      K +L+NP++   +L   ++++   G 
Sbjct: 296 LHVLETNDEKDQTANLTNQGKNITKNVTGFFQSFKSILTNPLYVMFVLLTLLQVSSYIGA 355

Query: 369 AAFLGKYLEQQFNLTTSSANQLLGMTAIPCACLGIFLGGLLVKKLSLSALGAIRMAMLVN 428
             ++ KY+EQQ+   +S AN LLG+  IP    G+FLGG ++KK  L+ +G  + +    
Sbjct: 356 FTYVFKYVEQQYGQPSSKANILLGVITIPIFASGMFLGGYIIKKFKLNTVGIAKFSCFTA 415

Query: 429 LVSTACYVSFLFLGCDTGPVAGVTVPY-GNSTAPGSALDPYSPCNNNCECQTDSFTPVCG 487
           ++S + Y+ + F+ C+   VAG+T+ Y GN+        P S CN++C C    + PVCG
Sbjct: 416 VMSLSFYLLYFFILCENKSVAGLTMTYDGNNPVTSHRDVPLSYCNSDCNCDESQWEPVCG 475

Query: 488 ADGITYLSACFAGCNSTN-------LTGCACL--TTVPAENATVVPGKCP-SPGCQEAFL 537
            +GITY+S C AGC S++          C+CL  T +   N +   G+CP    C   F 
Sbjct: 476 NNGITYISPCLAGCKSSSGNKKPIVFYNCSCLEVTGLQNRNYSAHLGECPRDDACTRKFY 535

Query: 538 TFLCVMCICSLIGAMAQTPSVIILIRTVSPELKSYALGVLFLLLRLLGFIPPPLIFGAGI 597
            F+ +  +     A+  T  V+++++ V PELKS ALG   +++R LG I  P+ FGA I
Sbjct: 536 FFVAIQVLNLFFSALGGTSHVMLIVKIVQPELKSLALGFHSMVIRALGGILAPIYFGALI 595

Query: 598 DSTCLFWST-FCGEQGACVLYDNVVYRYLYVSIAIALKSFAFILYTTTWQCLRKNYK 653
           D+TC+ WST  CG +G+C  Y++  +  +Y+ ++  L+  + +LY      ++K Y+
Sbjct: 596 DTTCIKWSTNNCGTRGSCRTYNSTSFSRVYLGLSSMLRVSSLVLYIILIYAMKKKYQ 652


>gi|223634012 solute carrier organic anion transporter family,
           member 2B1 isoform 2 [Homo sapiens]
          Length = 687

 Score =  384 bits (985), Expect = e-106
 Identities = 223/667 (33%), Positives = 353/667 (52%), Gaps = 45/667 (6%)

Query: 34  SCFSNIKIFLVSECALMLAQGTVGAYLVSVLTTLERRFNLQSADVGVIASSFEIGNLALI 93
           S F NIK+F++    L LAQ  +  YL S ++T+E+RF L S   G++AS  E+GN ALI
Sbjct: 21  SVFHNIKLFVLCHSLLQLAQLMISGYLKSSISTVEKRFGLSSQTSGLLASFNEVGNTALI 80

Query: 94  LFVSYFGARGHRPRLIGCGGIVMALGALLSALPEFLTHQYKYE--AGEIRWGAEGRDVCA 151
           +FVSYFG+R HRPR+IG G I++AL  LL  LP F++  Y+Y+  + E         +C 
Sbjct: 81  VFVSYFGSRVHRPRMIGYGAILVALAGLLMTLPHFISEPYRYDNTSPEDMPQDFKASLCL 140

Query: 152 ANGSGGDEGPDPDLICRNRTATNMMYL--LLIGAQVLLGIGATPVQPLGVSYIDDHVRRK 209
              S     P     C + T T  + +  ++  AQ LLG+G  P+QP G+SYIDD     
Sbjct: 141 PTTSAPASAPSNGN-CSSYTETQHLSVVGIMFVAQTLLGVGGVPIQPFGISYIDDFAHNS 199

Query: 210 DSSLYIGILFTMLVFGPACGFILGSFCTKIYVDAVFIDTSNLDITPDDPRWIGAWWGGFL 269
           +S LY+GILF + + GP   F LGS   ++YVD   +    + +T  DPRW+GAWW GFL
Sbjct: 200 NSPLYLGILFAVTMMGPGLAFGLGSLMLRLYVDINQMPEGGISLTIKDPRWVGAWWLGFL 259

Query: 270 LCGALLFFSSLLMFGFPQSLPPH--------------SEPAMESEQAMLSEREYERPKPS 315
           +    +  +++  F FP+ +P                  PA + + +   +   E  K  
Sbjct: 260 IAAGAVALAAIPYFFFPKEMPKEKRELQFRRKVLAVTDSPARKGKDSPSKQSPGESTKKQ 319

Query: 316 NGVLRHPLEPDSSASCFQQLRVIPKVTKHLLSNPVFTCIILAACMEIAVVAGFAAFLGKY 375
           +G+++  + P  + +  Q ++V P+V    L +P+F  ++L+     ++ AG A FL K+
Sbjct: 320 DGLVQ--IAP--NLTVIQFIKVFPRVLLQTLRHPIFLLVVLSQVCLSSMAAGMATFLPKF 375

Query: 376 LEQQFNLTTSSANQLLGMTAIPCACLGIFLGGLLVKKLSLSALGAIRMAMLVNLVSTACY 435
           LE+QF++T S AN L+G  + P   +GI +GG+LVK+L L  +G   + +L  L+     
Sbjct: 376 LERQFSITASYANLLIGCLSFPSVIVGIVVGGVLVKRLHLGPVGCGALCLLGMLLCLFFS 435

Query: 436 VSFLFLGCDTGPVAGVTVPYGNSTAPGSALDPYSPCNNNCECQTDSFTPVCG-ADGITYL 494
           +   F+GC +  +AG+T  +  S  PG  L P   C   C C  D F PVC  +  + Y+
Sbjct: 436 LPLFFIGCSSHQIAGIT--HQTSAHPGLELSP--SCMEACSCPLDGFNPVCDPSTRVEYI 491

Query: 495 SACFAGCNS-----------TNLTGCACLTTVPAENATVVPGKCPSPGCQEAFLTFLCVM 543
           + C AGC+S              T C+C+     E   V+ G C S  C    + FL ++
Sbjct: 492 TPCHAGCSSWVVQDALDNSQVFYTNCSCV----VEGNPVLAGSCDST-CSHLVVPFLLLV 546

Query: 544 CICSLIGAMAQTPSVIILIRTVSPELKSYALGVLFLLLRLLGFIPPPLIFGAGIDSTCLF 603
            + S +  +  TPS ++++R V  E K+ A+G+ F+ LR+L ++P P+I G+ ID+TC+ 
Sbjct: 547 SLGSALACLTHTPSFMLILRGVKKEDKTLAVGIQFMFLRILAWMPSPVIHGSAIDTTCVH 606

Query: 604 WSTFCGEQGACVLYDNVVYRYLYVSIAIALKSFAFILYTTTWQCLRKNYKRYIKNHEGGL 663
           W+  CG +  C  Y+N + R  ++ +    K+ + I +      LR+  K   +  E   
Sbjct: 607 WALSCGRRAVCRYYNNDLLRNRFIGLQFFFKTGSVICFALVLAVLRQQDKE-ARTKESRS 665

Query: 664 STSTEYQ 670
           S + E Q
Sbjct: 666 SPAVEQQ 672


>gi|6005820 solute carrier organic anion transporter family, member
           2B1 isoform 1 [Homo sapiens]
          Length = 709

 Score =  384 bits (985), Expect = e-106
 Identities = 223/667 (33%), Positives = 353/667 (52%), Gaps = 45/667 (6%)

Query: 34  SCFSNIKIFLVSECALMLAQGTVGAYLVSVLTTLERRFNLQSADVGVIASSFEIGNLALI 93
           S F NIK+F++    L LAQ  +  YL S ++T+E+RF L S   G++AS  E+GN ALI
Sbjct: 43  SVFHNIKLFVLCHSLLQLAQLMISGYLKSSISTVEKRFGLSSQTSGLLASFNEVGNTALI 102

Query: 94  LFVSYFGARGHRPRLIGCGGIVMALGALLSALPEFLTHQYKYE--AGEIRWGAEGRDVCA 151
           +FVSYFG+R HRPR+IG G I++AL  LL  LP F++  Y+Y+  + E         +C 
Sbjct: 103 VFVSYFGSRVHRPRMIGYGAILVALAGLLMTLPHFISEPYRYDNTSPEDMPQDFKASLCL 162

Query: 152 ANGSGGDEGPDPDLICRNRTATNMMYL--LLIGAQVLLGIGATPVQPLGVSYIDDHVRRK 209
              S     P     C + T T  + +  ++  AQ LLG+G  P+QP G+SYIDD     
Sbjct: 163 PTTSAPASAPSNGN-CSSYTETQHLSVVGIMFVAQTLLGVGGVPIQPFGISYIDDFAHNS 221

Query: 210 DSSLYIGILFTMLVFGPACGFILGSFCTKIYVDAVFIDTSNLDITPDDPRWIGAWWGGFL 269
           +S LY+GILF + + GP   F LGS   ++YVD   +    + +T  DPRW+GAWW GFL
Sbjct: 222 NSPLYLGILFAVTMMGPGLAFGLGSLMLRLYVDINQMPEGGISLTIKDPRWVGAWWLGFL 281

Query: 270 LCGALLFFSSLLMFGFPQSLPPH--------------SEPAMESEQAMLSEREYERPKPS 315
           +    +  +++  F FP+ +P                  PA + + +   +   E  K  
Sbjct: 282 IAAGAVALAAIPYFFFPKEMPKEKRELQFRRKVLAVTDSPARKGKDSPSKQSPGESTKKQ 341

Query: 316 NGVLRHPLEPDSSASCFQQLRVIPKVTKHLLSNPVFTCIILAACMEIAVVAGFAAFLGKY 375
           +G+++  + P  + +  Q ++V P+V    L +P+F  ++L+     ++ AG A FL K+
Sbjct: 342 DGLVQ--IAP--NLTVIQFIKVFPRVLLQTLRHPIFLLVVLSQVCLSSMAAGMATFLPKF 397

Query: 376 LEQQFNLTTSSANQLLGMTAIPCACLGIFLGGLLVKKLSLSALGAIRMAMLVNLVSTACY 435
           LE+QF++T S AN L+G  + P   +GI +GG+LVK+L L  +G   + +L  L+     
Sbjct: 398 LERQFSITASYANLLIGCLSFPSVIVGIVVGGVLVKRLHLGPVGCGALCLLGMLLCLFFS 457

Query: 436 VSFLFLGCDTGPVAGVTVPYGNSTAPGSALDPYSPCNNNCECQTDSFTPVCG-ADGITYL 494
           +   F+GC +  +AG+T  +  S  PG  L P   C   C C  D F PVC  +  + Y+
Sbjct: 458 LPLFFIGCSSHQIAGIT--HQTSAHPGLELSP--SCMEACSCPLDGFNPVCDPSTRVEYI 513

Query: 495 SACFAGCNS-----------TNLTGCACLTTVPAENATVVPGKCPSPGCQEAFLTFLCVM 543
           + C AGC+S              T C+C+     E   V+ G C S  C    + FL ++
Sbjct: 514 TPCHAGCSSWVVQDALDNSQVFYTNCSCV----VEGNPVLAGSCDST-CSHLVVPFLLLV 568

Query: 544 CICSLIGAMAQTPSVIILIRTVSPELKSYALGVLFLLLRLLGFIPPPLIFGAGIDSTCLF 603
            + S +  +  TPS ++++R V  E K+ A+G+ F+ LR+L ++P P+I G+ ID+TC+ 
Sbjct: 569 SLGSALACLTHTPSFMLILRGVKKEDKTLAVGIQFMFLRILAWMPSPVIHGSAIDTTCVH 628

Query: 604 WSTFCGEQGACVLYDNVVYRYLYVSIAIALKSFAFILYTTTWQCLRKNYKRYIKNHEGGL 663
           W+  CG +  C  Y+N + R  ++ +    K+ + I +      LR+  K   +  E   
Sbjct: 629 WALSCGRRAVCRYYNNDLLRNRFIGLQFFFKTGSVICFALVLAVLRQQDKE-ARTKESRS 687

Query: 664 STSTEYQ 670
           S + E Q
Sbjct: 688 SPAVEQQ 694


>gi|225543116 solute carrier organic anion transporter family,
           member 1C1 isoform 3 [Homo sapiens]
          Length = 663

 Score =  373 bits (957), Expect = e-103
 Identities = 212/642 (33%), Positives = 341/642 (53%), Gaps = 74/642 (11%)

Query: 30  KKKVSCFSNIKIFLVSECALMLAQGTVGAYLVSVLTTLERRFNLQSADVGVIASSFEIGN 89
           ++K  C   +K+FL +   +  A+     YL S +T +ERRF++ S+ VGVI  SFEIGN
Sbjct: 33  EEKQPCCGELKVFLCALSFVYFAKALAEGYLKSTITQIERRFDIPSSLVGVIDGSFEIGN 92

Query: 90  LALILFVSYFGARGHRPRLIGCGGIVMALGALLSALPEFLTHQYKYEAGEIRWGAEGRDV 149
           L +I FVSYFGA+ HRP++IG G ++M +G LL A+P+F   QYKYE             
Sbjct: 93  LLVITFVSYFGAKLHRPKIIGAGCVIMGVGTLLIAMPQFFMEQYKYE------------- 139

Query: 150 CAANGSGGDEGPDPDLICRNRTATNMMYLLLIGAQVLLGIGATPVQPLGVSYIDDHVRRK 209
                               R + +    L I   +L      PV  +          + 
Sbjct: 140 --------------------RYSPSSNSTLSISPCLLESSSQLPVSVM---------EKS 170

Query: 210 DSSLYIGILFTMLVFGPACGFILGSFCTKIYVDAVFIDTSNLDITPDDPRWIGAWWGGFL 269
            S +  G + T+ + GP  GF+LGS C K+YVD  F++  ++ ITP DP+W+GAWW G+L
Sbjct: 171 KSKISNGCVQTVAIIGPIFGFLLGSLCAKLYVDIGFVNLDHITITPKDPQWVGAWWLGYL 230

Query: 270 LCGALLFFSSLLMFGFPQSLP-----PHSEPAMESEQAMLSER-EYERPKPSNGVLRHPL 323
           + G +   +++  +  P+SLP       S  + E  + ++ +  +Y+ P+  N       
Sbjct: 231 IAGIISLLAAVPFWYLPKSLPRSQSREDSNSSSEKSKFIIDDHTDYQTPQGEN------- 283

Query: 324 EPDSSASCFQQLRVIPKVTKHLLSNPVFTCIILAACMEIAVVAGFAAFLGKYLEQQFNLT 383
                A   +  R      K+L  NPV+   +  + ++   + G   +  KY+EQQ+  +
Sbjct: 284 -----AKIMEMARDFLPSLKNLFGNPVYFLYLCTSTVQFNSLFGMVTYKPKYIEQQYGQS 338

Query: 384 TSSANQLLGMTAIPCACLGIFLGGLLVKKLSLSALGAIRMAMLVNLVSTACYVSFLFLGC 443
           +S AN ++G+  IP   LGIF GG+++KK  +S  GA ++ +  ++     ++S   LGC
Sbjct: 339 SSRANFVIGLINIPAVALGIFSGGIVMKKFRISVCGAAKLYLGSSVFGYLLFLSLFALGC 398

Query: 444 DTGPVAGVTVPYGNSTAPGSALDP--YSPCNNNCECQTDSFTPVCGADGITYLSACFAGC 501
           +   VAG+TV Y   T P S  +   +S CN+ C+C    + P+CG +GITY+SAC AGC
Sbjct: 399 ENSDVAGLTVSY-QGTKPVSYHERALFSDCNSRCKCSETKWEPMCGENGITYVSACLAGC 457

Query: 502 NSTNLTG-------CACLTTVPAE--NATVVPGKCPSP-GCQEAFLTFLCVMCICSLIGA 551
            ++N +G       C C+    ++  N++ + G+C    GC + FL FL +  I S   +
Sbjct: 458 QTSNRSGKNIIFYNCTCVGIAASKSGNSSGIVGRCQKDNGCPQMFLYFLVISVITSYTLS 517

Query: 552 MAQTPSVIILIRTVSPELKSYALGVLFLLLRLLGFIPPPLIFGAGIDSTCLFWS-TFCGE 610
           +   P  I+L+R + P+LKS+ALG+  L +R+L  IP P+ FG  ID++CL W    CG 
Sbjct: 518 LGGIPGYILLLRCIKPQLKSFALGIYTLAIRVLAGIPAPVYFGVLIDTSCLKWGFKRCGS 577

Query: 611 QGACVLYDNVVYRYLYVSIAIALKSFAFILYTTTWQCLRKNY 652
           +G+C LYD+ V+R++Y+ + + L + + +L       L+KNY
Sbjct: 578 RGSCRLYDSNVFRHIYLGLTVILGTVSILLSIAVLFILKKNY 619


>gi|38679890 solute carrier organic anion transporter family, member
           4C1 [Homo sapiens]
          Length = 724

 Score =  358 bits (919), Expect = 9e-99
 Identities = 217/626 (34%), Positives = 332/626 (53%), Gaps = 68/626 (10%)

Query: 42  FLVSECALMLAQGTVGAYLVSV-LTTLERRFNLQSADVGVIASSFEIGNLALILFVSYFG 100
           FL+  C L + QG V   LV++ ++T+E+R+ ++S+  G+I+SS++I    L LFVS+FG
Sbjct: 107 FLLHYCLLAVTQGIVVNGLVNISISTVEKRYEMKSSLTGLISSSYDISFCLLSLFVSFFG 166

Query: 101 ARGHRPRLIGCGGIVMALGALLSALPEFLTHQYKYEAGEIRWGAEGRDVCAANGSGGDEG 160
            RGH+PR +     ++ LGAL+ +LP+F + +YK        G+   D C    +     
Sbjct: 167 ERGHKPRWLAFAAFMIGLGALVFSLPQFFSGEYKL-------GSLFEDTCVTTRNSTS-- 217

Query: 161 PDPDLICRNRTAT--NMMYLLLIGAQVLLGIGATPVQPLGVSYIDDHVRRKDSSLYIGIL 218
                 C + T++  N +Y+ ++G Q+LLG G TP+  LG +++DD V    SSLYIG  
Sbjct: 218 ------CTSSTSSLSNYLYVFILG-QLLLGAGGTPLYTLGTAFLDDSVPTHKSSLYIGTG 270

Query: 219 FTMLVFGPACGFILGSFCTKIYVDAVFIDTSNLDITPDDPRWIGAWWGGFLLCGALLFFS 278
           + M + GPA G++LG     IY+D    +++  D+T DDPRW+GAWW GFLL     +  
Sbjct: 271 YAMSILGPAIGYVLGGQLLTIYIDVAMGEST--DVTEDDPRWLGAWWIGFLLSWIFAWSL 328

Query: 279 SLLMFGFPQSLPPHSE-PAMESEQAMLSEREYERPKPSNGVLRHPLEPDSSASCFQQLRV 337
            +    FP+ LP  +E  A ++ QA                  H    ++     + ++ 
Sbjct: 329 IIPFSCFPKHLPGTAEIQAGKTSQA------------------HQSNSNADVKFGKSIKD 370

Query: 338 IPKVTKHLLSNPVFTCIILAACMEIAVVAGFAAFLGKYLEQQFNLTTSSANQLLGMTAIP 397
            P   K+L+ N VF C++L+   E  +  GFA FL K++E QF LT+S A  L G   IP
Sbjct: 371 FPAALKNLMKNAVFMCLVLSTSSEALITTGFATFLPKFIENQFGLTSSFAATLGGAVLIP 430

Query: 398 CACLGIFLGGLLVKKLSLSALGAIRMAMLVNLVSTACYVSFLFLGCDTGPVAGVTVPYGN 457
            A LG  LGG LV K  ++    ++ A+  + V+      F++  C+  P AGV+  Y  
Sbjct: 431 GAALGQILGGFLVSKFRMTCKNTMKFALFTSGVALTLSFVFMYAKCENEPFAGVSESYNG 490

Query: 458 STAPGSALDPYSPCNNNCECQTDSFTPVCGADGITYLSACFAGCNS-------TNLTGCA 510
           +   G+ +   +PCN NC C    + PVCG DG+ Y S CFAGC++            C+
Sbjct: 491 TGELGNLI---APCNANCNCSRSYYYPVCG-DGVQYFSPCFAGCSNPVAHRKPKVYYNCS 546

Query: 511 CL-------TTVPAENATVVPGKCPSPGCQEAFLTFLCVMCICSLIGAMAQTPSVIILIR 563
           C+       +T          GKC +  C +  + FLC+  I  +   MA TP  + ++R
Sbjct: 547 CIERKTEITSTAETFGFEAKAGKCET-HCAKLPI-FLCIFFIVIIFTFMAGTPITVSILR 604

Query: 564 TVSPELKSYALGVLFLLLRLLGFIPPPLIFGAGIDSTCLFWS-TFCGEQGACVLYDNVVY 622
            V+   +S ALG+ F++LRLLG IP P+IFG  IDSTC+ W    CG +GAC +YDN+  
Sbjct: 605 CVNHRQRSLALGIQFMVLRLLGTIPGPIIFGFTIDSTCILWDINDCGIKGACWIYDNIKM 664

Query: 623 RYLYVSIAIALK-------SFAFILY 641
            ++ V+I++  K        FA  LY
Sbjct: 665 AHMLVAISVTCKVITMFFNGFAIFLY 690


>gi|39777594 solute carrier organic anion transporter family member
           4A1 [Homo sapiens]
          Length = 722

 Score =  351 bits (901), Expect = 1e-96
 Identities = 212/616 (34%), Positives = 320/616 (51%), Gaps = 57/616 (9%)

Query: 47  CALMLAQG-TVGAYLVSVLTTLERRFNLQSADVGVIASSFEIGNLALILFVSYFGARGHR 105
           CA    QG TV  ++ +V+T+LERR++L S   G+IASS++I     + FVSYFG  GH+
Sbjct: 110 CAAAFLQGMTVNGFINTVITSLERRYDLHSYQSGLIASSYDIAACLCLTFVSYFGGSGHK 169

Query: 106 PRLIGCGGIVMALGALLSALPEFLTHQYKYEAGEIRWGAEGRDVCAANGSGGDEGPDPDL 165
           PR +G G ++M  G+L+ ALP F   +Y+ E         G   C AN         P  
Sbjct: 170 PRWLGWGVLLMGTGSLVFALPHFTAGRYEVELD------AGVRTCPAN---------PGA 214

Query: 166 ICRNRTATNMMY-LLLIGAQVLLGIGATPVQPLGVSYIDDHVRRKDSSLYIGILFTMLVF 224
           +C + T+    Y L+ +  Q L G+GATP+  LGV+Y+D++V+   S +YI I +T  + 
Sbjct: 215 VCADSTSGLSRYQLVFMLGQFLHGVGATPLYTLGVTYLDENVKSSCSPVYIAIFYTAAIL 274

Query: 225 GPACGFILGSFCTKIYVDAVFIDTSNLDITPDDPRWIGAWWGGFLLCGALLFFSSLLMFG 284
           GPA G+++G     IY +         ++T + P W+GAWW GFL  GA  FF+++ + G
Sbjct: 275 GPAAGYLIGGALLNIYTEM----GRRTELTTESPLWVGAWWVGFLGSGAAAFFTAVPILG 330

Query: 285 FPQSLPPHSEPAMESEQAMLSEREYERPKPSNGVLRHPLEPDSSASCFQQLRVIPKVTKH 344
           +P+ LP     A+     M   ++  R + SN        PD      + +R +P     
Sbjct: 331 YPRQLPGSQRYAVMRAAEMHQLKDSSRGEASN--------PDFG----KTIRDLPLSIWL 378

Query: 345 LLSNPVFTCIILAACMEIAVVAGFAAFLGKYLEQQFNLTTSSANQLLGMTAIPCACLGIF 404
           LL NP F  + LA   E  ++ G + F  K+LE QF+L+ S A  L G   +P    G F
Sbjct: 379 LLKNPTFILLCLAGATEATLITGMSTFSPKFLESQFSLSASEAATLFGYLVVPAGGGGTF 438

Query: 405 LGGLLVKKLSLSALGAIRMAMLVNLVSTACYVSFLFLGCDTGPVAGVTVPYGNSTAPGSA 464
           LGG  V KL L     I+  +   +VS    + F  L C + P+AGVT  YG S  P   
Sbjct: 439 LGGFFVNKLRLRGSAVIKFCLFCTVVSLLGILVF-SLHCPSVPMAGVTASYGGSLLPEGH 497

Query: 465 LDPYSPCNNNCECQTDSFTPVCGADGITYLSACFAGC---NSTNLTG------CACL-TT 514
           L+  +PCN  C CQ + ++PVCG+DG+ Y S C AGC     TN+ G      C+C+   
Sbjct: 498 LNLTAPCNAACSCQPEHYSPVCGSDGLMYFSLCHAGCPAATETNVDGQKVYRDCSCIPQN 557

Query: 515 VPAENATVVPGKCPSPGCQE--AFLTFLCVMCICSLIGAMAQTPSVIILIRTVSPELKSY 572
           + +       GKC S  CQ     L F+ V+   + + ++   P++   +R V    +S+
Sbjct: 558 LSSGFGHATAGKCTST-CQRKPLLLVFIFVVIFFTFLSSI---PALTATLRCVRDPQRSF 613

Query: 573 ALGVLFLLLRLLGFIPPPLIFGAGIDSTCLFWSTFCGEQGACVLYDN-------VVYRYL 625
           ALG+ ++++R+LG IP P+ FG  ID  CL W   CG+QG+C++Y N       ++   L
Sbjct: 614 ALGIQWIVVRILGGIPGPIAFGWVIDKACLLWQDQCGQQGSCLVYQNSAMSRYILIMGLL 673

Query: 626 YVSIAIALKSFAFILY 641
           Y  + +   + A  LY
Sbjct: 674 YKVLGVLFFAIACFLY 689


>gi|116812593 liver-specific organic anion transporter 3TM12 [Homo
           sapiens]
          Length = 640

 Score =  342 bits (877), Expect = 7e-94
 Identities = 208/607 (34%), Positives = 321/607 (52%), Gaps = 31/607 (5%)

Query: 65  TTLERRFNLQSADVGVIASSFEIGNLALILFVSYFGARGHRPRLIGCGGIVMALGALLSA 124
           T +ERRF + S+ VG+I  SFEIGNL +I+FVSYFG++ HRP+LIG G  +M  G++L A
Sbjct: 6   TQIERRFEISSSLVGLIDGSFEIGNLFVIVFVSYFGSKLHRPKLIGIGCFLMGTGSILMA 65

Query: 125 LPEFLTHQYKYEAGEIRWGAEGRDV----CAANGSGGDEGPDPDLICRN--RTATNMMYL 178
           LP F    Y+Y        +E        C  N          ++I R   + + + M++
Sbjct: 66  LPHFFMGYYRYSKETNIDPSENSTSNLPNCLINQMLSLNRTPSEIIERGCVKESGSHMWI 125

Query: 179 LLIGAQVLLGIGATPVQPLGVSYIDDHVRRKDSSLYIGILFTMLVFGPACGFILGSFCTK 238
            +    +L GIG TP+ PLG+SYIDD  +   SSLY+G +  M + G    F+LGS   K
Sbjct: 126 YVFMGNMLRGIGETPIVPLGISYIDDFAKEGHSSLYLGTVNVMGMTGLVFAFMLGSLFAK 185

Query: 239 IYVDAVFIDTSNLDITPDDPRWIGAWWGGFLLCGALLFFSSLLMFGFPQSLPPHSEPAME 298
           +YVD  ++D S + ITP D RW+GAWW GFL+ G +   SS+  F  P  L P ++P  E
Sbjct: 186 MYVDIGYVDLSTIRITPKDSRWVGAWWLGFLVSGIVSIISSIPFFFLP--LNP-NKPQKE 242

Query: 299 SEQAM---LSEREYERPKPSNGVLRHPLEPDSSASCFQQLRVIPKVTKHLLSNPVFTCII 355
            + ++   + +   +R + +N   R      +    FQ L       K +L+NP++   +
Sbjct: 243 RKVSLFLHVLKTNDKRNQIANLTNRRKYITKNVTGFFQSL-------KSILTNPLYVIFV 295

Query: 356 LAACMEIAVVAGFAAFLGKYLEQQFNLTTSSANQLLGMTAIPCACLGIFLGGLLVKKLSL 415
           +   + ++       ++ K +EQQ+  + S  N LLG+ A+P   +G+F GG ++KK  L
Sbjct: 296 IFTLLHMSSYIASLTYIIKMVEQQYGWSASKTNFLLGVLALPAVAIGMFSGGYIIKKFKL 355

Query: 416 SALGAIRMAMLVNLVSTACYVSFLFLGCDTGPVAGVTVPY-GNSTAPGSALDPYSPCNNN 474
           S +G  ++A     V     V + FL C++  VAG+T+ Y GNS        P S CN+ 
Sbjct: 356 SLVGLAKLAFCSATVHLLSQVLYFFLICESKSVAGLTLTYDGNSPVRSHVDVPLSYCNSE 415

Query: 475 CECQTDSFTPVCGADGITYLSACFAGCNSTN-------LTGCACLTTVPAENATVVP--G 525
           C C    + PVCG +GITYLS C AGC S++          C+C+  +  +N       G
Sbjct: 416 CNCDESQWEPVCGNNGITYLSPCLAGCKSSSGNKEPIVFYNCSCVEVIGLQNKNYSAHLG 475

Query: 526 KCP-SPGCQEAFLTFLCVMCICSLIGAMAQTPSVIILIRTVSPELKSYALGVLFLLLRLL 584
           +CP    C      +  +  + + + A+  T   +++IR V PELK+ A+G   +++R L
Sbjct: 476 ECPRDDACTRKSYVYFVIQVLDAFLCAVGLTSYSVLVIRIVQPELKALAIGFHSMIMRSL 535

Query: 585 GFIPPPLIFGAGIDSTCLFWST-FCGEQGACVLYDNVVYRYLYVSIAIALKSFAFILYTT 643
           G I  P+ FGA ID+TC+ WST  CG +GAC +Y++      +  + +AL     +L T 
Sbjct: 536 GGILVPIYFGALIDTTCMKWSTNSCGARGACRIYNSTYLGRAFFGLKVALIFPVLVLLTV 595

Query: 644 TWQCLRK 650
               +RK
Sbjct: 596 FIFVVRK 602


>gi|225637475 solute carrier organic anion transporter family,
           member 5A1 isoform 3 [Homo sapiens]
          Length = 793

 Score =  331 bits (848), Expect = 2e-90
 Identities = 219/691 (31%), Positives = 340/691 (49%), Gaps = 114/691 (16%)

Query: 40  KIFLVSECALMLAQGT-VGAYLVSVLTTLERRFNLQSADVGVIASSFEIGNLALILFVSY 98
           + FLV  C L   Q   V  YL SV+TT+ERR++L+S++ G++ S F+IGNL +++FVSY
Sbjct: 128 RCFLVCMCFLTFIQALMVSGYLSSVITTIERRYSLKSSESGLLVSCFDIGNLVVVVFVSY 187

Query: 99  FGARGHRPRLIGCGGIVMALGALLSALPEFLTHQYKYEAGEIRWGAEGRDVCAANGSGGD 158
           FG RG RP  +  GG+++A GA L ALP F++  Y+ +  E+   A    +C    S   
Sbjct: 188 FGGRGRRPLWLAVGGLLIAFGAALFALPHFISPPYQIQ--ELNASAPNDGLCQGGNSTAT 245

Query: 159 EGPDPDLICRNRTATNMMYL---LLIGAQVLLGIGATPVQPLGVSYIDDHVRRKDSSLYI 215
             P     C   +  N  ++   L I AQ+L+G+G+TP+  LG +Y+DD+V++++SSLY+
Sbjct: 246 LEPP---ACPKDSGGNNHWVYVALFICAQILIGMGSTPIYTLGPTYLDDNVKKENSSLYL 302

Query: 216 GILFTMLVFGPACGFILGSFCTKIYVDAVFIDTSNLDITPDDPRWIGAWWGGFLLCGALL 275
            I++ M   GPA G++LG      YVD      + + +  +DPR+IG WW GFLLC   +
Sbjct: 303 AIMYVMGALGPAVGYLLGGLLIGFYVD----PRNPVHLDQNDPRFIGNWWSGFLLCAIAM 358

Query: 276 FFSSLLMFGFPQSLPPHSEPAMESEQAM--LSEREYERPKPSNGVLRHPLEPDSSASCFQ 333
           F     MF FP+ LPP  +   + + ++  +S+ +  + K +N                 
Sbjct: 359 FLVIFPMFTFPKKLPPRHKKKKKKKFSVDAVSDDDVLKEKSNNSE--------------- 403

Query: 334 QLRVIPKVTKHLLSNPVFTCIILAACMEIAVVAGFAAFLGKYLEQQFNLTTSSANQLLGM 393
             +   KV+       V   II+ +       AG    LG Y                  
Sbjct: 404 --QADKKVSSMGFGKDVRGVIIVPS-------AGVGIVLGGY------------------ 436

Query: 394 TAIPCACLGIFLGGLLVKKLSLSALGAIRMAMLVNLVSTACYVSFLFLGCDTGPVAGVTV 453
                          ++KKL L A  + ++AM+ + VS  C+ +   +GC++  + G+ +
Sbjct: 437 ---------------IIKKLKLGARESAKLAMICSGVSLLCFSTLFIVGCESINLGGINI 481

Query: 454 PYGNSTAPGSAL---DPYSPCNNNCECQTDSFTPVCGADGITYLSACFAGC-NSTNL--- 506
           PY  +T P   +   +    CN NC C+   + PVCG+DGITY + C AGC NS NL   
Sbjct: 482 PY--TTGPSLTMPHRNLTGSCNVNCGCKIHEYEPVCGSDGITYFNPCLAGCVNSGNLSTG 539

Query: 507 ----TGCAC----------------------LTTVPAENATVVPGKCPSPGCQEAFLTFL 540
               T C C                      + T   EN   V GKC    C    + FL
Sbjct: 540 IRNYTECTCVQSRQVITPPTVGQRSQLRVVIVKTYLNENGYAVSGKCKRT-C-NTLIPFL 597

Query: 541 CVMCICSLIGAMAQTPSVIILIRTVSPELKSYALGVLFLLLRLLGFIPPPLIFGAGIDST 600
             + I + I A AQ  ++I+ +R+V  E + +ALG+ F+LLR L +IP P+ FGA ID+T
Sbjct: 598 VFLFIVTFITACAQPSAIIVTLRSVEDEERPFALGMQFVLLRTLAYIPTPIYFGAVIDTT 657

Query: 601 CLFWSTFCGEQGACVLYDNVVYRYLYVSIAIALKSFAFILYTTTWQCL--RKNYKRYIKN 658
           C+ W   CG QG+C  Y+   +R++Y  +A  LK   FI     W  +  +++  +  + 
Sbjct: 658 CMLWQQECGVQGSCWEYNVTSFRFVYFGLAAGLKFVGFIFIFLAWYSIKYKEDGLQRRRQ 717

Query: 659 HEGGLSTSTE---YQDIETEKTCPESHSPSE 686
            E  LST +E   + D    ++CP   +  E
Sbjct: 718 REFPLSTVSERVGHPDNARTRSCPAFSTQGE 748


>gi|225543114 solute carrier organic anion transporter family,
           member 1C1 isoform 4 [Homo sapiens]
          Length = 612

 Score =  324 bits (831), Expect = 1e-88
 Identities = 181/545 (33%), Positives = 295/545 (54%), Gaps = 49/545 (8%)

Query: 116 MALGALLSALPEFLTHQYKYEAGEIRWGAEGRDVCAANGSGGDEGPDPDLI--------- 166
           M +G LL A+P+F   QYKYE    R+        + +    +      +          
Sbjct: 1   MGVGTLLIAMPQFFMEQYKYE----RYSPSSNSTLSISPCLLESSSQLPVSVMEKSKSKI 56

Query: 167 ---CRNRTATNMMYLLLIGAQVLLGIGATPVQPLGVSYIDDHVRRKDSSLYIGILFTMLV 223
              C   T+++M   + +G  +L GIG TP+QPLG++Y+DD     +++ YIG + T+ +
Sbjct: 57  SNECEVDTSSSMWIYVFLG-NLLRGIGETPIQPLGIAYLDDFASEDNAAFYIGCVQTVAI 115

Query: 224 FGPACGFILGSFCTKIYVDAVFIDTSNLDITPDDPRWIGAWWGGFLLCGALLFFSSLLMF 283
            GP  GF+LGS C K+YVD  F++  ++ ITP DP+W+GAWW G+L+ G +   +++  +
Sbjct: 116 IGPIFGFLLGSLCAKLYVDIGFVNLDHITITPKDPQWVGAWWLGYLIAGIISLLAAVPFW 175

Query: 284 GFPQSLP-----PHSEPAMESEQAMLSER-EYERPKPSNGVLRHPLEPDSSASCFQQLRV 337
             P+SLP       S  + E  + ++ +  +Y+ P+  N            A   +  R 
Sbjct: 176 YLPKSLPRSQSREDSNSSSEKSKFIIDDHTDYQTPQGEN------------AKIMEMARD 223

Query: 338 IPKVTKHLLSNPVFTCIILAACMEIAVVAGFAAFLGKYLEQQFNLTTSSANQLLGMTAIP 397
                K+L  NPV+   +  + ++   + G   +  KY+EQQ+  ++S AN ++G+  IP
Sbjct: 224 FLPSLKNLFGNPVYFLYLCTSTVQFNSLFGMVTYKPKYIEQQYGQSSSRANFVIGLINIP 283

Query: 398 CACLGIFLGGLLVKKLSLSALGAIRMAMLVNLVSTACYVSFLFLGCDTGPVAGVTVPYGN 457
              LGIF GG+++KK  +S  GA ++ +  ++     ++S   LGC+   VAG+TV Y  
Sbjct: 284 AVALGIFSGGIVMKKFRISVCGAAKLYLGSSVFGYLLFLSLFALGCENSDVAGLTVSY-Q 342

Query: 458 STAPGSALDP--YSPCNNNCECQTDSFTPVCGADGITYLSACFAGCNSTNLTG------- 508
            T P S  +   +S CN+ C+C    + P+CG +GITY+SAC AGC ++N +G       
Sbjct: 343 GTKPVSYHERALFSDCNSRCKCSETKWEPMCGENGITYVSACLAGCQTSNRSGKNIIFYN 402

Query: 509 CACLTTVPAE--NATVVPGKCPSP-GCQEAFLTFLCVMCICSLIGAMAQTPSVIILIRTV 565
           C C+    ++  N++ + G+C    GC + FL FL +  I S   ++   P  I+L+R +
Sbjct: 403 CTCVGIAASKSGNSSGIVGRCQKDNGCPQMFLYFLVISVITSYTLSLGGIPGYILLLRCI 462

Query: 566 SPELKSYALGVLFLLLRLLGFIPPPLIFGAGIDSTCLFWS-TFCGEQGACVLYDNVVYRY 624
            P+LKS+ALG+  L +R+L  IP P+ FG  ID++CL W    CG +G+C LYD+ V+RY
Sbjct: 463 KPQLKSFALGIYTLAIRVLAGIPAPVYFGVLIDTSCLKWGFKRCGSRGSCRLYDSNVFRY 522

Query: 625 LYVSI 629
              SI
Sbjct: 523 QIKSI 527


>gi|225637477 solute carrier organic anion transporter family,
           member 5A1 isoform 2 [Homo sapiens]
          Length = 687

 Score =  319 bits (817), Expect = 6e-87
 Identities = 190/560 (33%), Positives = 298/560 (53%), Gaps = 50/560 (8%)

Query: 40  KIFLVSECALMLAQGT-VGAYLVSVLTTLERRFNLQSADVGVIASSFEIGNLALILFVSY 98
           + FLV  C L   Q   V  YL SV+TT+ERR++L+S++ G++ S F+IGNL +++FVSY
Sbjct: 128 RCFLVCMCFLTFIQALMVSGYLSSVITTIERRYSLKSSESGLLVSCFDIGNLVVVVFVSY 187

Query: 99  FGARGHRPRLIGCGGIVMALGALLSALPEFLTHQYKYEAGEIRWGAEGRDVCAANGSGGD 158
           FG RG RP  +  GG+++A GA L ALP F++  Y+ +  E+   A    +C    S   
Sbjct: 188 FGGRGRRPLWLAVGGLLIAFGAALFALPHFISPPYQIQ--ELNASAPNDGLCQGGNSTAT 245

Query: 159 EGPDPDLICRNRTATNMMYL---LLIGAQVLLGIGATPVQPLGVSYIDDHVRRKDSSLYI 215
             P     C   +  N  ++   L I AQ+L+G+G+TP+  LG +Y+DD+V++++SSLY+
Sbjct: 246 LEPP---ACPKDSGGNNHWVYVALFICAQILIGMGSTPIYTLGPTYLDDNVKKENSSLYL 302

Query: 216 GILFTMLVFGPACGFILGSFCTKIYVDAVFIDTSNLDITPDDPRWIGAWWGGFLLCGALL 275
            I++ M   GPA G++LG      YVD      + + +  +DPR+IG WW GFLLC   +
Sbjct: 303 AIMYVMGALGPAVGYLLGGLLIGFYVD----PRNPVHLDQNDPRFIGNWWSGFLLCAIAM 358

Query: 276 FFSSLLMFGFPQSLPPHSEPAMESEQAMLSEREYERPKPSNGVLRHPLEPDSSASCFQQL 335
           F     MF FP+ LPP  +   + + ++ +  + +  K  +       +  SS    + +
Sbjct: 359 FLVIFPMFTFPKKLPPRHKKKKKKKFSVDAVSDDDVLKEKSNNSEQADKKVSSMGFGKDV 418

Query: 336 RVIPKVTKHLLSNPVFTCIILAACMEIAVVAGFAAFLGKYLEQQFNLTTSSANQLLGMTA 395
           R +P+    +LSN  F  + L+   E A+V  F  F+ K++E QF +  S+A+   G+  
Sbjct: 419 RDLPRAAVRILSNMTFLFVSLSYTAESAIVTAFITFIPKFIESQFGIPASNASIYTGVII 478

Query: 396 IPCACLGIFLGGLLVKKLSLSALGAIRMAMLVNLVSTACYVSFLFLGCDTGPVAGVTVPY 455
           +P A +GI LGG ++KKL L A  + ++AM+ + VS  C+ +   +GC++  + G+ +PY
Sbjct: 479 VPSAGVGIVLGGYIIKKLKLGARESAKLAMICSGVSLLCFSTLFIVGCESINLGGINIPY 538

Query: 456 GNSTAPGSAL---DPYSPCNNNCECQTDSFTPVCGADGITYLSACFAGC-NSTNL----- 506
             +T P   +   +    CN NC C+   + PVCG+DGITY + C AGC NS NL     
Sbjct: 539 --TTGPSLTMPHRNLTGSCNVNCGCKIHEYEPVCGSDGITYFNPCLAGCVNSGNLSTGIR 596

Query: 507 --TGCAC----------------------LTTVPAENATVVPGKCPSPGCQEAFLTFLCV 542
             T C C                      + T   EN   V GKC    C    + FL  
Sbjct: 597 NYTECTCVQSRQVITPPTVGQRSQLRVVIVKTYLNENGYAVSGKCKRT-C-NTLIPFLVF 654

Query: 543 MCICSLIGAMAQTPSVIILI 562
           + I + I A AQ  ++I+ +
Sbjct: 655 LFIVTFITACAQPSAIIVTL 674


>gi|223634014 solute carrier organic anion transporter family,
           member 2B1 isoform 3 [Homo sapiens]
          Length = 565

 Score =  293 bits (751), Expect = 3e-79
 Identities = 167/528 (31%), Positives = 273/528 (51%), Gaps = 44/528 (8%)

Query: 173 TNMMYLLLIG----AQVLLGIGATPVQPLGVSYIDDHVRRKDSSLYIGILFTMLVFGPAC 228
           T   +L ++G    AQ LLG+G  P+QP G+SYIDD     +S LY+GILF + + GP  
Sbjct: 37  TETQHLSVVGIMFVAQTLLGVGGVPIQPFGISYIDDFAHNSNSPLYLGILFAVTMMGPGL 96

Query: 229 GFILGSFCTKIYVDAVFIDTSNLDITPDDPRWIGAWWGGFLLCGALLFFSSLLMFGFPQS 288
            F LGS   ++YVD   +    + +T  DPRW+GAWW GFL+    +  +++  F FP+ 
Sbjct: 97  AFGLGSLMLRLYVDINQMPEGGISLTIKDPRWVGAWWLGFLIAAGAVALAAIPYFFFPKE 156

Query: 289 LPPH--------------SEPAMESEQAMLSEREYERPKPSNGVLRHPLEPDSSASCFQQ 334
           +P                  PA + + +   +   E  K  +G+++  + P  + +  Q 
Sbjct: 157 MPKEKRELQFRRKVLAVTDSPARKGKDSPSKQSPGESTKKQDGLVQ--IAP--NLTVIQF 212

Query: 335 LRVIPKVTKHLLSNPVFTCIILAACMEIAVVAGFAAFLGKYLEQQFNLTTSSANQLLGMT 394
           ++V P+V    L +P+F  ++L+     ++ AG A FL K+LE+QF++T S AN L+G  
Sbjct: 213 IKVFPRVLLQTLRHPIFLLVVLSQVCLSSMAAGMATFLPKFLERQFSITASYANLLIGCL 272

Query: 395 AIPCACLGIFLGGLLVKKLSLSALGAIRMAMLVNLVSTACYVSFLFLGCDTGPVAGVTVP 454
           + P   +GI +GG+LVK+L L  +G   + +L  L+     +   F+GC +  +AG+T  
Sbjct: 273 SFPSVIVGIVVGGVLVKRLHLGPVGCGALCLLGMLLCLFFSLPLFFIGCSSHQIAGIT-- 330

Query: 455 YGNSTAPGSALDPYSPCNNNCECQTDSFTPVCG-ADGITYLSACFAGCNS---------- 503
           +  S  PG  L P   C   C C  D F PVC  +  + Y++ C AGC+S          
Sbjct: 331 HQTSAHPGLELSP--SCMEACSCPLDGFNPVCDPSTRVEYITPCHAGCSSWVVQDALDNS 388

Query: 504 -TNLTGCACLTTVPAENATVVPGKCPSPGCQEAFLTFLCVMCICSLIGAMAQTPSVIILI 562
               T C+C+     E   V+ G C S  C    + FL ++ + S +  +  TPS ++++
Sbjct: 389 QVFYTNCSCV----VEGNPVLAGSCDST-CSHLVVPFLLLVSLGSALACLTHTPSFMLIL 443

Query: 563 RTVSPELKSYALGVLFLLLRLLGFIPPPLIFGAGIDSTCLFWSTFCGEQGACVLYDNVVY 622
           R V  E K+ A+G+ F+ LR+L ++P P+I G+ ID+TC+ W+  CG +  C  Y+N + 
Sbjct: 444 RGVKKEDKTLAVGIQFMFLRILAWMPSPVIHGSAIDTTCVHWALSCGRRAVCRYYNNDLL 503

Query: 623 RYLYVSIAIALKSFAFILYTTTWQCLRKNYKRYIKNHEGGLSTSTEYQ 670
           R  ++ +    K+ + I +      LR+  K   +  E   S + E Q
Sbjct: 504 RNRFIGLQFFFKTGSVICFALVLAVLRQQDKE-ARTKESRSSPAVEQQ 550


>gi|93277099 solute carrier organic anion transporter family, member
           6A1 [Homo sapiens]
          Length = 719

 Score =  228 bits (581), Expect = 1e-59
 Identities = 163/625 (26%), Positives = 281/625 (44%), Gaps = 56/625 (8%)

Query: 35  CFSNIKIFLVSECALMLAQGTVGAYLVSVLTTLERRFNLQSADVGVIASSFEIGNLALIL 94
           C +NI+ F++  C L++ QG V   +   +   ++ + L++ +   +  S++I +  + +
Sbjct: 101 CCNNIRCFMIFYCILLICQGVVFGLIDVSIGDFQKEYQLKTIEKLALEKSYDISSGLVAI 160

Query: 95  FVSYFGARGHRPRLIGCGGIVMALGALLSALPEFLTHQYKYEAGEIRWGAEGRDVCAANG 154
           F++++G R      +     ++ LG+LL A P       + + G      E + V     
Sbjct: 161 FIAFYGDRKKVIWFVA-SSFLIGLGSLLCAFPSINEENKQSKVGIEDICEEIKVVSGCQS 219

Query: 155 SGGDEGPDPDLICRNRTATNMMYL-LLIGAQVLLGIGATPVQPLGVSYIDDHVRRKDSSL 213
           SG               +    YL   I  Q + GI   P+  LG+++ID++V    + +
Sbjct: 220 SG--------------ISFQSKYLSFFILGQTVQGIAGMPLYILGITFIDENVATHSAGI 265

Query: 214 YIGILFTMLVFGPACGFILGSFCTKIYVDAVFIDTSNLDITPDDPRWIGAWWGGFLLCGA 273
           Y+GI     + G A G++LG+   K+  +      +N  +    P W+  WW  FL    
Sbjct: 266 YLGIAECTSMIGYALGYVLGAPLVKVPENTT--SATNTTVNNGSPEWLWTWWINFLFAAV 323

Query: 274 LLFFSSLLMFGFPQSLPPHSE-PAMESEQAMLSEREYERPKPSNGVLRHPLEPDSSASCF 332
           + + + + +  FP ++P  +   A + +Q    +   +  K    +       D  A+ +
Sbjct: 324 VAWCTLIPLSCFPNNMPGSTRIKARKRKQLHFFDSRLKDLKLGTNI------KDLCAALW 377

Query: 333 QQLRVIPKVTKHLLSNPVFTCIILAACMEIAVVAGFAAFLGKYLEQQFNLTTSSANQLLG 392
                       L+ NPV  C+ L+   E  V+ G + FL  YLE QF LT + A  L G
Sbjct: 378 I-----------LMKNPVLICLALSKATEYLVIIGASEFLPIYLENQFILTPTVATTLAG 426

Query: 393 MTAIPCACLGIFLGGLLVKKLSLSALGAIRMAMLVNLVSTACYVSFLFLGCDTGPVAGVT 452
           +  IP   LG  LGG++V  L +S    +R  M+ +++S    V  +F+ C+    AG+ 
Sbjct: 427 LVLIPGGALGQLLGGVIVSTLEMSCKALMRFIMVTSVISLILLVFIIFVRCNPVQFAGIN 486

Query: 453 VPYGNSTAPGSALDPYSPCNNNCECQTDSFTPVCGADGITYLSACFAGCNSTNLT----- 507
             Y  +   G+     +PCN  C C +  ++ +CG D I Y S CFAGC  +        
Sbjct: 487 EDYDGTGKLGNLT---APCNEKCRCSSSIYSSICGRDDIEYFSPCFAGCTYSKAQNQKKM 543

Query: 508 --GCAC----LTTVPAENATV--VPGKCPSPGCQEAFLTFLCVMCICSLIGAMAQTPSVI 559
              C+C    L T  AE   +   PGKC +  C +  L F+  +    +    +  P V+
Sbjct: 544 YYNCSCIKEGLITADAEGDFIDARPGKCDAK-CYKLPL-FIAFIFSTLIFSGFSGVPIVL 601

Query: 560 ILIRTVSPELKSYALGVLFLLLRLLGFIPPPLIFGAGIDSTCLFWS-TFCGEQGACVLYD 618
            + R V  +L+S ALGV +++LR+ G IP P IF    +++C+      CG  G C +Y+
Sbjct: 602 AMTRVVPDKLRSLALGVSYVILRIFGTIPGPSIFKMSGETSCILRDVNKCGHTGRCWIYN 661

Query: 619 NVVYRYLYVSIAIALKSFAFILYTT 643
                +L V I    K    I++TT
Sbjct: 662 KTKMAFLLVGICFLCK-LCTIIFTT 685


>gi|11863156 RECK protein precursor [Homo sapiens]
          Length = 971

 Score = 37.0 bits (84), Expect = 0.061
 Identities = 16/27 (59%), Positives = 17/27 (62%), Gaps = 1/27 (3%)

Query: 475 CECQTDSFTPVCGADGITYLSACFAGC 501
           C C  D F PVCG +G TY SAC A C
Sbjct: 633 CNC-ADQFVPVCGQNGRTYPSACIARC 658



 Score = 30.0 bits (66), Expect = 7.5
 Identities = 37/143 (25%), Positives = 57/143 (39%), Gaps = 18/143 (12%)

Query: 462 GSALDPYSPCNNNCECQTDSFTPVCGADGITYLSACFAGCN--STNLTGCACLTTVPAEN 519
           G +L    PC   C        PVCG +G TY S C A  +  + +  G      V +E+
Sbjct: 741 GKSLSYKGPCQPFCRATE----PVCGHNGETYSSVCAAYSDRVAVDYYGDCQAVGVLSEH 796

Query: 520 ATV---VPGKCPS---PGCQEAFLTFLCVMCICSLIGAMAQTPSVIILIRTVSPELKSYA 573
           ++V      KCPS    GC+       C    C L   M +       + T++       
Sbjct: 797 SSVAECASVKCPSLLAAGCKPIIPPGAC----CPLCAGMLRVLFDKEKLDTIAKVTNKKP 852

Query: 574 LGVLFLL--LRLLGFIPPPLIFG 594
           + VL +L  +R+   +P   +FG
Sbjct: 853 ITVLEILQKIRMHVSVPQCDVFG 875


>gi|238859649 keratin associated protein 10-8 [Homo sapiens]
          Length = 259

 Score = 36.2 bits (82), Expect = 0.10
 Identities = 35/126 (27%), Positives = 47/126 (37%), Gaps = 31/126 (24%)

Query: 444 DTGPVAGVTVPYGNSTAPGSALDPYSPCNNNC----ECQTDSFTPVCGADGITYL----- 494
           D G V+ V+ P   ST  GS+      C  +C     C +   TP C A           
Sbjct: 23  DVGHVSRVSSP---STCTGSSWQ-VDNCQESCCEPRSCASSCCTPSCCAPAPCLALVCAP 78

Query: 495 -----SACFAGCNSTNLTGC--------ACLTTVPAENATVVPGKCPSPGCQEAFLTFLC 541
                S C +GC  +    C        AC T+ P + A  VP  C S  C+      +C
Sbjct: 79  VSCEPSPCQSGCTDSCTPSCCQQSSCQPACCTSSPCQQACCVPVCCKSNCCKP-----VC 133

Query: 542 VMCICS 547
            + ICS
Sbjct: 134 CVSICS 139


>gi|118600977 C3 and PZP-like, alpha-2-macroglobulin domain containing
            8 [Homo sapiens]
          Length = 1932

 Score = 35.4 bits (80), Expect = 0.18
 Identities = 19/50 (38%), Positives = 25/50 (50%), Gaps = 10/50 (20%)

Query: 471  CNNNCECQTDSFTPVCGADGITYLSACFAGCNSTNLTGCACLTTVPAENA 520
            C+++C  Q +   PVCG+DG+ Y SAC        L   AC    P E A
Sbjct: 1759 CDHDCGAQGN---PVCGSDGVVYASAC-------RLREAACRQAAPLEPA 1798


>gi|54873613 agrin [Homo sapiens]
          Length = 2045

 Score = 35.0 bits (79), Expect = 0.23
 Identities = 13/28 (46%), Positives = 19/28 (67%)

Query: 470 PCNNNCECQTDSFTPVCGADGITYLSAC 497
           PC  +  CQ+   +PVCG+DG+TY + C
Sbjct: 702 PCVCDFSCQSVPGSPVCGSDGVTYSTEC 729



 Score = 34.7 bits (78), Expect = 0.30
 Identities = 22/58 (37%), Positives = 26/58 (44%), Gaps = 10/58 (17%)

Query: 477 CQTDSFTPVCGADGITYLSACFAGCNSTNLTGCACLTTVPAENATVVP---GKCPSPG 531
           C+     PVCG+DG+TY SAC        L   ACL     E A   P    +C S G
Sbjct: 623 CEHPPPGPVCGSDGVTYGSAC-------ELREAACLQQTQIEEARAGPCEQAECGSGG 673



 Score = 33.9 bits (76), Expect = 0.52
 Identities = 26/79 (32%), Positives = 33/79 (41%), Gaps = 18/79 (22%)

Query: 475 CECQ---TDSFTPVCGADGITYLSACFAGCNSTNLTGCACLTTVPAENATVVPGKCPSPG 531
           CEC    +  + PVCG+DG+TY SAC        L   AC  T+  E      G C    
Sbjct: 488 CECLQACSSLYDPVCGSDGVTYGSAC-------ELEATAC--TLGREIQVARKGPCDR-- 536

Query: 532 CQEAFLTFLCV----MCIC 546
           C +     LC      C+C
Sbjct: 537 CGQCRFGALCEAETGRCVC 555



 Score = 29.6 bits (65), Expect = 9.8
 Identities = 21/72 (29%), Positives = 29/72 (40%), Gaps = 13/72 (18%)

Query: 475 CECQTDSFT---PVCGADGITYLSACFAGCNS---------TNLTGC-ACLTTVPAENAT 521
           C C ++      PVCG+DG TY S C    ++          +   C  C   V A  A 
Sbjct: 553 CVCPSECVALAQPVCGSDGHTYPSECMLHVHACTHQISLHVASAGPCETCGDAVCAFGAV 612

Query: 522 VVPGKCPSPGCQ 533
              G+C  P C+
Sbjct: 613 CSAGQCVCPRCE 624


>gi|29568105 transmembrane protein with EGF-like and two
           follistatin-like domains 1 [Homo sapiens]
          Length = 380

 Score = 33.5 bits (75), Expect = 0.68
 Identities = 13/28 (46%), Positives = 17/28 (60%)

Query: 471 CNNNCECQTDSFTPVCGADGITYLSACF 498
           C  N +C   SF PVC +DG +Y + CF
Sbjct: 188 CVCNIDCSGYSFNPVCASDGSSYNNPCF 215



 Score = 29.6 bits (65), Expect = 9.8
 Identities = 13/27 (48%), Positives = 16/27 (59%), Gaps = 3/27 (11%)

Query: 475 CECQTDSFT---PVCGADGITYLSACF 498
           C CQ    T   PVCG++G TY + CF
Sbjct: 97  CACQFQCHTNYIPVCGSNGDTYQNECF 123


>gi|169212028 PREDICTED: keratin-associated protein 9-2-like 2-like
           [Homo sapiens]
          Length = 160

 Score = 33.1 bits (74), Expect = 0.89
 Identities = 21/83 (25%), Positives = 31/83 (37%), Gaps = 6/83 (7%)

Query: 469 SPCNNNCECQTDSFTPVCGADGITYLSACFAGC-NSTNLTGCACLTTVPAENATVVPG-- 525
           S C  +C C T  + P+C        ++C + C  S++     C  T        +PG  
Sbjct: 74  SCCQPSC-CSTPCYQPICCGSSCCGQTSCGSSCGQSSSCAPVYCRRTCYHPTTVCLPGCL 132

Query: 526 --KCPSPGCQEAFLTFLCVMCIC 546
              C S  CQ  +    CV   C
Sbjct: 133 NQSCGSSCCQPCYCPACCVSSCC 155


>gi|46250735 keratin associated protein 10-2 [Homo sapiens]
          Length = 255

 Score = 33.1 bits (74), Expect = 0.89
 Identities = 24/104 (23%), Positives = 38/104 (36%), Gaps = 6/104 (5%)

Query: 447 PVAGVTVPYGNSTAPGSALDPYSPCNNNCE---CQTDSFTPVCGADGITYLSACF-AGCN 502
           PV+ V+ P   +    SA    S C ++C    CQ  S  P C        + C    C 
Sbjct: 49  PVSCVSSPCCQAACEPSACQ--SGCTSSCTPSCCQQSSCQPACCTSSPCQQACCVPVCCK 106

Query: 503 STNLTGCACLTTVPAENATVVPGKCPSPGCQEAFLTFLCVMCIC 546
                   C  +   + ++  P  C S  CQ++    +C   +C
Sbjct: 107 PVCCVPVCCGASSCCQQSSCQPACCASSSCQQSCRVPVCCKAVC 150


>gi|63053512 keratin associated protein 10-1 [Homo sapiens]
          Length = 282

 Score = 32.7 bits (73), Expect = 1.2
 Identities = 27/104 (25%), Positives = 40/104 (38%), Gaps = 23/104 (22%)

Query: 461 PGSALDPYSPCNNNCECQTDSFTPVCGADGITYLSACFAGC---------NSTNLTGC-- 509
           P   L   S  +++C CQ  S  P C A   +  S C   C          S + + C  
Sbjct: 107 PVCCLPTCSKDSSSC-CQQSSCQPTCCASSSSQQSCCVPVCCKPVCYVPTCSEDSSSCCQ 165

Query: 510 ------ACLTTVPAENATVVPGKCPSPGCQEAFLTFLCVMCICS 547
                 AC T+ P + A  VP +C    C+      +C + +CS
Sbjct: 166 QSSCHPACCTSSPCQQACCVPVRCKPVCCKP-----ICCVPVCS 204



 Score = 30.8 bits (68), Expect = 4.4
 Identities = 24/90 (26%), Positives = 34/90 (37%), Gaps = 3/90 (3%)

Query: 461 PGSALDPYSPCNNNCECQTDSFTPVCGADGITYLSACFAGCN-STNLTGCACLTTVPA-E 518
           P S  +P+  C  +C       T VC          C A C  S   +GC    T    +
Sbjct: 23  PESCCEPHC-CALSCCAPAPCLTLVCTPVSRVSSPCCQAACEPSPCQSGCTSSCTPSCCQ 81

Query: 519 NATVVPGKCPSPGCQEAFLTFLCVMCICSL 548
            ++  P  C S  CQ+A    +C   +C L
Sbjct: 82  QSSCQPACCTSSPCQQACCVPVCCKPVCCL 111


>gi|32140182 keratin associated protein 10-10 [Homo sapiens]
          Length = 251

 Score = 32.7 bits (73), Expect = 1.2
 Identities = 29/117 (24%), Positives = 41/117 (35%), Gaps = 17/117 (14%)

Query: 432 TACYVSFLFLGCDTGPVAGVTVPYGNSTAPGSALDPYSPCNNNCECQTDSFTPVCGADGI 491
           TAC  S     C +G  +  T P    ++        SPC   C C      PVC     
Sbjct: 55  TACEPS----ACQSGYTSSCTTPCYQQSSCQPDCCTSSPCQQAC-CVPVCCVPVC----- 104

Query: 492 TYLSACFAGCNSTNLTGCACLTTVPA--ENATVVPGKCPSPGCQEAFLTFLCVMCIC 546
                C   CN        C  + P+  + ++  P  C S  CQ+A    +C   +C
Sbjct: 105 -----CVPVCNKPVCFVPTCSESSPSCCQQSSCQPTCCTSSPCQQACCVPVCSKSVC 156



 Score = 31.6 bits (70), Expect = 2.6
 Identities = 32/126 (25%), Positives = 48/126 (38%), Gaps = 10/126 (7%)

Query: 424 AMLVNLVSTACYVSFLFLGCDTGPVAGVTVPYGNSTAPGSAL--DPYSPCNNNCECQTDS 481
           A  +++ S+AC  S+  + C          P   + AP   L   P S  ++ C CQT  
Sbjct: 3   ASTMSICSSACTDSWRVVDCPES----CCEPCCCAPAPSLTLVCTPVSCVSSPC-CQTAC 57

Query: 482 FTPVCGADGITYLSACFAGCNSTNLTGCACLTTVPAENATVVPGKCPSPGCQEAFLTFLC 541
               C +    Y S+C   C   +     C T+ P + A  VP  C    C       +C
Sbjct: 58  EPSACQSG---YTSSCTTPCYQQSSCQPDCCTSSPCQQACCVPVCCVPVCCVPVCNKPVC 114

Query: 542 VMCICS 547
            +  CS
Sbjct: 115 FVPTCS 120


  Database: hs.faa
    Posted date:  Aug 4, 2009  4:42 PM
  Number of letters in database: 18,247,518
  Number of sequences in database:  37,866
  
Lambda     K      H
   0.323    0.139    0.434 

Gapped
Lambda     K      H
   0.267   0.0410    0.140 


Matrix: BLOSUM62
Gap Penalties: Existence: 11, Extension: 1
Number of Hits to DB: 27,824,956
Number of Sequences: 37866
Number of extensions: 1293832
Number of successful extensions: 4000
Number of sequences better than 10.0: 30
Number of HSP's better than 10.0 without gapping: 28
Number of HSP's successfully gapped in prelim test: 36
Number of HSP's that attempted gapping in prelim test: 3823
Number of HSP's gapped (non-prelim): 117
length of query: 692
length of database: 18,247,518
effective HSP length: 109
effective length of query: 583
effective length of database: 14,120,124
effective search space: 8232032292
effective search space used: 8232032292
T: 11
A: 40
X1: 16 ( 7.5 bits)
X2: 38 (14.6 bits)
X3: 64 (24.7 bits)
S1: 41 (22.0 bits)
S2: 65 (29.6 bits)
Search results were obtained with NCBI BLAST and RefSeq entries.