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Search of human proteins with 222352168
BLASTP 2.2.11 [Jun-05-2005]
Reference: Altschul, Stephen F., Thomas L. Madden, Alejandro A. Schaffer,
Jinghui Zhang, Zheng Zhang, Webb Miller, and David J. Lipman (1997),
"Gapped BLAST and PSI-BLAST: a new generation of protein database search
programs", Nucleic Acids Res. 25:3389-3402.
Query= gi|222352168 hypothetical protein LOC389161 [Homo sapiens]
(544 letters)
Database: hs.faa
37,866 sequences; 18,247,518 total letters
Searching..................................................done
Score E
Sequences producing significant alignments: (bits) Value
gi|222352168 hypothetical protein LOC389161 [Homo sapiens] 1100 0.0
gi|239746532 PREDICTED: ankyrin repeat domain 60 [Homo sapiens] 46 1e-04
gi|239757533 PREDICTED: ankyrin repeat domain 60 [Homo sapiens] 44 4e-04
gi|239752049 PREDICTED: ankyrin repeat domain 60 [Homo sapiens] 44 4e-04
gi|68131557 ankyrin repeat domain 28 [Homo sapiens] 42 0.001
gi|41327752 diabetes related ankyrin repeat protein [Homo sapiens] 41 0.002
gi|116875852 HECT domain and ankyrin repeat containing, E3 ubiqu... 40 0.007
gi|67191208 ubiquitin C [Homo sapiens] 40 0.007
gi|24233530 ankyrin repeat domain 44 [Homo sapiens] 39 0.009
gi|11024714 ubiquitin B precursor [Homo sapiens] 39 0.009
gi|241896857 hypothetical protein LOC100287718 [Homo sapiens] 38 0.027
gi|239754321 PREDICTED: similar to ankyrin repeat domain 2 [Homo... 38 0.027
gi|224465233 euchromatic histone-lysine N-methyltransferase 1 is... 37 0.035
gi|148596917 fibronectin type III and ankyrin repeat domains 1 [... 37 0.046
gi|157743284 ankyrin repeat domain 52 [Homo sapiens] 37 0.046
gi|156142199 euchromatic histone-lysine N-methyltransferase 2 is... 36 0.10
gi|156142197 euchromatic histone-lysine N-methyltransferase 2 is... 36 0.10
gi|19718741 oxysterol-binding protein-like 1A isoform B [Homo sa... 35 0.13
gi|110431370 espin [Homo sapiens] 35 0.13
gi|188595682 ankyrin 2 isoform 3 [Homo sapiens] 35 0.18
gi|52426737 ankyrin 2 isoform 2 [Homo sapiens] 35 0.18
gi|52426735 ankyrin 2 isoform 1 [Homo sapiens] 35 0.18
gi|215598574 ankyrin 1 isoform 9 [Homo sapiens] 35 0.18
gi|70780359 ankyrin 1 isoform 1 [Homo sapiens] 35 0.18
gi|70780357 ankyrin 1 isoform 3 [Homo sapiens] 35 0.18
gi|70780355 ankyrin 1 isoform 2 [Homo sapiens] 35 0.18
gi|70780353 ankyrin 1 isoform 4 [Homo sapiens] 35 0.18
gi|116063534 ankyrin repeat domain 27 (VPS9 domain) [Homo sapiens] 35 0.23
gi|30425444 ankyrin repeat and kinase domain containing 1 [Homo ... 34 0.39
gi|38683807 ankyrin repeat domain protein 17 isoform a [Homo sap... 33 0.51
>gi|222352168 hypothetical protein LOC389161 [Homo sapiens]
Length = 544
Score = 1100 bits (2845), Expect = 0.0
Identities = 544/544 (100%), Positives = 544/544 (100%)
Query: 1 MRIFIAFEGSFEPFDVSADETVEVVKLMIKDYFHIPLSEDKQGRRYLELMYAGAALKDSW 60
MRIFIAFEGSFEPFDVSADETVEVVKLMIKDYFHIPLSEDKQGRRYLELMYAGAALKDSW
Sbjct: 1 MRIFIAFEGSFEPFDVSADETVEVVKLMIKDYFHIPLSEDKQGRRYLELMYAGAALKDSW 60
Query: 61 SLADVGISFCSTLKCFVKEEDKPTLYVFNAVTQDTMPVMESISLLDKTVSDLRTLVTLRC 120
SLADVGISFCSTLKCFVKEEDKPTLYVFNAVTQDTMPVMESISLLDKTVSDLRTLVTLRC
Sbjct: 61 SLADVGISFCSTLKCFVKEEDKPTLYVFNAVTQDTMPVMESISLLDKTVSDLRTLVTLRC 120
Query: 121 GLPVSVYCLRTPRGLEMYDCNTLKDYQTDIGTTLRLDVWDGWKEFLMGCLLGQKLKVQRY 180
GLPVSVYCLRTPRGLEMYDCNTLKDYQTDIGTTLRLDVWDGWKEFLMGCLLGQKLKVQRY
Sbjct: 121 GLPVSVYCLRTPRGLEMYDCNTLKDYQTDIGTTLRLDVWDGWKEFLMGCLLGQKLKVQRY 180
Query: 181 LSKEGPVLKYQKRVALYIAAFCGYIELTEWALKQGARPHEAVGVHPYRAWCHEALHADVS 240
LSKEGPVLKYQKRVALYIAAFCGYIELTEWALKQGARPHEAVGVHPYRAWCHEALHADVS
Sbjct: 181 LSKEGPVLKYQKRVALYIAAFCGYIELTEWALKQGARPHEAVGVHPYRAWCHEALHADVS 240
Query: 241 KCPIHAAAEAGQLLILKAFVNYSVLCLECKNAAGQTPLTIVFKHKHKDCVLYLLSKMWST 300
KCPIHAAAEAGQLLILKAFVNYSVLCLECKNAAGQTPLTIVFKHKHKDCVLYLLSKMWST
Sbjct: 241 KCPIHAAAEAGQLLILKAFVNYSVLCLECKNAAGQTPLTIVFKHKHKDCVLYLLSKMWST 300
Query: 301 VSFPKISVPMRIYIKIKQWILRAQSHSLHKSQFCGARVFGAKVGDTVMVDGFTKPKMTSK 360
VSFPKISVPMRIYIKIKQWILRAQSHSLHKSQFCGARVFGAKVGDTVMVDGFTKPKMTSK
Sbjct: 301 VSFPKISVPMRIYIKIKQWILRAQSHSLHKSQFCGARVFGAKVGDTVMVDGFTKPKMTSK 360
Query: 361 SWHKAGNSDSQSIVLKLPSLSKQTASSKPVNPLAISQPDTRKQALKFHPLVNASSFSELQ 420
SWHKAGNSDSQSIVLKLPSLSKQTASSKPVNPLAISQPDTRKQALKFHPLVNASSFSELQ
Sbjct: 361 SWHKAGNSDSQSIVLKLPSLSKQTASSKPVNPLAISQPDTRKQALKFHPLVNASSFSELQ 420
Query: 421 KHQQQNQKKITATARKKEKLIKNTYLPQVPLPPVSRVGYSHPSFFYATPSADFLLKSSFS 480
KHQQQNQKKITATARKKEKLIKNTYLPQVPLPPVSRVGYSHPSFFYATPSADFLLKSSFS
Sbjct: 421 KHQQQNQKKITATARKKEKLIKNTYLPQVPLPPVSRVGYSHPSFFYATPSADFLLKSSFS 480
Query: 481 SFLEHSGKTPWENAIYCLAVASAFKEKRWLQQLEIARVLAKKSISNLTTRGGLTACENSL 540
SFLEHSGKTPWENAIYCLAVASAFKEKRWLQQLEIARVLAKKSISNLTTRGGLTACENSL
Sbjct: 481 SFLEHSGKTPWENAIYCLAVASAFKEKRWLQQLEIARVLAKKSISNLTTRGGLTACENSL 540
Query: 541 ETVL 544
ETVL
Sbjct: 541 ETVL 544
>gi|239746532 PREDICTED: ankyrin repeat domain 60 [Homo sapiens]
Length = 345
Score = 45.8 bits (107), Expect = 1e-04
Identities = 46/200 (23%), Positives = 86/200 (43%), Gaps = 35/200 (17%)
Query: 106 DKTVSDLRTLVTLRCGLPVSVYCLRTPRGLEMYDCNTLKDYQTDIGTTLRLDVW--DGWK 163
D TV +L+ + L G+P ++ L+ + D TLK + G + L +W DGW
Sbjct: 115 DMTVRELKEELDLMVGIPFNLQRLQYLDEGVLMDDTTLKFHDVVPGGIISLCIWHHDGWT 174
Query: 164 EFLMGCLLGQKLKVQ----------RYLSK---EGPVLKY----QKRVALYIAAFCGYIE 206
E ++ + G K+ R + EG K+ + VALY+A+ G+ +
Sbjct: 175 ELVLAAVEGDPSKLSCLGLTEDSFYRTANSEHFEGEKWKHWTSQRAFVALYVASHRGHFD 234
Query: 207 LTEWALKQGARPHEAVGVHPYRAWCHEALHADVSKCPIHAAAEAGQLLILKAFVNYSVLC 266
++ L+ GA C + + + P+H AA G+ + + +
Sbjct: 235 AVQYLLEHGAS-------------C--LSRSPLGRTPLHVAAAMGRSDCIILLLQHGA-S 278
Query: 267 LECKNAAGQTPLTIVFKHKH 286
+ ++A G+TP++I + H
Sbjct: 279 IHDRDAKGETPISIAHRLNH 298
>gi|239757533 PREDICTED: ankyrin repeat domain 60 [Homo sapiens]
Length = 337
Score = 43.9 bits (102), Expect = 4e-04
Identities = 46/200 (23%), Positives = 85/200 (42%), Gaps = 35/200 (17%)
Query: 106 DKTVSDLRTLVTLRCGLPVSVYCLRTPRGLEMYDCNTLKDYQTDIGTTLRLDVW--DGWK 163
D TV +L+ + L G+P ++ L+ + D TLK + G + L +W DGW
Sbjct: 107 DMTVRELKEELDLMVGIPFNLQRLQYLDEGVLMDDTTLKFHDVVPGGIISLCIWHHDGWT 166
Query: 164 EFLMGCLLGQKLKVQ----------RYLSK---EGPVLKY----QKRVALYIAAFCGYIE 206
E ++ + G K+ R + EG K+ + VALY+A+ G+ +
Sbjct: 167 ELVLAAVEGDPSKLSCLGLTEDSFYRTANSEHFEGEKWKHWTSQRAFVALYVASHRGHFD 226
Query: 207 LTEWALKQGARPHEAVGVHPYRAWCHEALHADVSKCPIHAAAEAGQLLILKAFVNYSVLC 266
++ L+ GA C + + + P+H AA G+ + + +
Sbjct: 227 AVQYLLEHGAS-------------C--LSRSPLGRTPLHVAAAMGRSDCIILLLQHGA-S 270
Query: 267 LECKNAAGQTPLTIVFKHKH 286
+ ++A G+TP++I H
Sbjct: 271 IHDRDAKGETPISIAHCLNH 290
>gi|239752049 PREDICTED: ankyrin repeat domain 60 [Homo sapiens]
Length = 337
Score = 43.9 bits (102), Expect = 4e-04
Identities = 46/200 (23%), Positives = 85/200 (42%), Gaps = 35/200 (17%)
Query: 106 DKTVSDLRTLVTLRCGLPVSVYCLRTPRGLEMYDCNTLKDYQTDIGTTLRLDVW--DGWK 163
D TV +L+ + L G+P ++ L+ + D TLK + G + L +W DGW
Sbjct: 107 DMTVRELKEELDLMVGIPFNLQRLQYLDEGVLMDDTTLKFHDVVPGGIISLCIWHHDGWT 166
Query: 164 EFLMGCLLGQKLKVQ----------RYLSK---EGPVLKY----QKRVALYIAAFCGYIE 206
E ++ + G K+ R + EG K+ + VALY+A+ G+ +
Sbjct: 167 ELVLAAVEGDPSKLSCLGLTEDSFYRTANSEHFEGEKWKHWTSQRAFVALYVASHRGHFD 226
Query: 207 LTEWALKQGARPHEAVGVHPYRAWCHEALHADVSKCPIHAAAEAGQLLILKAFVNYSVLC 266
++ L+ GA C + + + P+H AA G+ + + +
Sbjct: 227 AVQYLLEHGAS-------------C--LSRSPLGRTPLHVAAAMGRSDCIILLLQHGA-S 270
Query: 267 LECKNAAGQTPLTIVFKHKH 286
+ ++A G+TP++I H
Sbjct: 271 IHDRDAKGETPISIAHCLNH 290
>gi|68131557 ankyrin repeat domain 28 [Homo sapiens]
Length = 1053
Score = 42.4 bits (98), Expect = 0.001
Identities = 32/106 (30%), Positives = 51/106 (48%), Gaps = 16/106 (15%)
Query: 193 RVALYIAAFCGYIELTEWALKQGARPHEAVGVHPYRAWCHEALHADVSKCPIHAAAEAGQ 252
R L +AAF G++E + + QGA ++ V Y + + PIHAAA G
Sbjct: 584 RTPLDLAAFKGHVECVDVLINQGA----SILVKDYI----------LKRTPIHAAATNGH 629
Query: 253 LLILKAFVNYSVL--CLECKNAAGQTPLTIVFKHKHKDCVLYLLSK 296
L+ + + ++ ++ GQTPL + + H DCV LL+K
Sbjct: 630 SECLRLLIGNAEPQNAVDIQDGNGQTPLMLSVLNGHTDCVYSLLNK 675
Score = 35.0 bits (79), Expect = 0.18
Identities = 33/107 (30%), Positives = 48/107 (44%), Gaps = 21/107 (19%)
Query: 193 RVALYIAAFCGYIELTEWALKQGARPHEAVGVHPYRA--WCHEALHADVSK--------- 241
R AL+ AAF G+ E+ + L +GA + A RA W H +V K
Sbjct: 141 RTALHHAAFSGHGEMVKLLLSRGANIN-AFDKKDRRAIHWAAYMGHIEVVKLLVSHGAEV 199
Query: 242 --------CPIHAAAEAGQLLILKAFVNYSVLCLECKNAAGQTPLTI 280
P+HAAA +G + ++K ++ V E NA G TPL +
Sbjct: 200 TCKDKKSYTPLHAAASSGMISVVKYLLDLGVDMNE-PNAYGNTPLHV 245
Score = 34.7 bits (78), Expect = 0.23
Identities = 19/54 (35%), Positives = 32/54 (59%), Gaps = 1/54 (1%)
Query: 243 PIHAAAEAGQLLILKAFVNYSVLCLECKNAAGQTPLTIVFKHKHKDCVLYLLSK 296
P+H AA G L+ V S+L L+ +N++G+TPL + H +CV L+++
Sbjct: 553 PLHLAAYHGHHQALEVLVQ-SLLDLDVRNSSGRTPLDLAAFKGHVECVDVLINQ 605
>gi|41327752 diabetes related ankyrin repeat protein [Homo sapiens]
Length = 305
Score = 41.2 bits (95), Expect = 0.002
Identities = 34/136 (25%), Positives = 57/136 (41%), Gaps = 18/136 (13%)
Query: 161 GWKEFLMGCLLGQKLKVQRYLSKEGPVLKYQK--RVALYIAAFCGYIELTEWALKQGARP 218
G + FL Q+ + +YL+ G + K R AL+ A G+ +L L GA
Sbjct: 111 GLEMFLKAAAENQEYLIDKYLTDGGDPNAHDKLHRTALHWACLKGHSQLVNKLLVAGA-- 168
Query: 219 HEAVGVHPYRAWCHEALHADVSKCPIHAAAEAGQLLILKAFVNYSVLCLECKNAAGQTPL 278
V + + P+ A G L+ILK +N + ++ G TPL
Sbjct: 169 --TVDARDL-----------LDRTPVFWACRGGHLVILKQLLNQGAR-VNARDKIGSTPL 214
Query: 279 TIVFKHKHKDCVLYLL 294
+ + +H DC+ +L+
Sbjct: 215 HVAVRTRHPDCLEHLI 230
>gi|116875852 HECT domain and ankyrin repeat containing, E3
ubiquitin protein ligase 1 [Homo sapiens]
Length = 909
Score = 39.7 bits (91), Expect = 0.007
Identities = 27/81 (33%), Positives = 36/81 (44%), Gaps = 17/81 (20%)
Query: 192 KRVALYIAAFCGYIELTEWALKQGARPHEAVGVHPYRAWCHEALHADVSKC-PIHAAAEA 250
KR L+IAA CG +E LK+GA P+ + D+S C P+H AA
Sbjct: 65 KRSLLHIAANCGSVECLVLLLKKGANPN----------------YQDISGCTPLHLAARN 108
Query: 251 GQLLILKAFVNYSVLCLECKN 271
GQ + + YS C N
Sbjct: 109 GQKKCMSKLLEYSADVNICNN 129
>gi|67191208 ubiquitin C [Homo sapiens]
Length = 685
Score = 39.7 bits (91), Expect = 0.007
Identities = 41/157 (26%), Positives = 71/157 (45%), Gaps = 13/157 (8%)
Query: 1 MRIFI-AFEGSFEPFDVSADETVEVVKLMIKDYFHIPLSEDKQGRRYLELMYAGAALKDS 59
M+IF+ G +V +T+E VK I+D IP + + L++AG L+D
Sbjct: 153 MQIFVKTLTGKTITLEVEPSDTIENVKAKIQDKEGIPSDQQR-------LIFAGKQLEDG 205
Query: 60 WSLADVGISFCSTLKCFVKEEDKPTLYVFNAVTQDTMPVMESISLLDKTVSDLRTLVTLR 119
+L+D I STL ++ ++V +T T+ + S T+ +++ + +
Sbjct: 206 RTLSDYNIQKESTLHLVLRLRGGMQIFV-KTLTGKTITLEVEPS---DTIENVKAKIQDK 261
Query: 120 CGLPVSVYCLRTPRGLEMYDCNTLKDYQTDIGTTLRL 156
G+P L G ++ D TL DY +TL L
Sbjct: 262 EGIPPDQQRL-IFAGKQLEDGRTLSDYNIQKESTLHL 297
Score = 39.3 bits (90), Expect = 0.009
Identities = 41/157 (26%), Positives = 71/157 (45%), Gaps = 13/157 (8%)
Query: 1 MRIFI-AFEGSFEPFDVSADETVEVVKLMIKDYFHIPLSEDKQGRRYLELMYAGAALKDS 59
M+IF+ G +V +T+E VK I+D IP + + L++AG L+D
Sbjct: 1 MQIFVKTLTGKTITLEVEPSDTIENVKAKIQDKEGIPPDQQR-------LIFAGKQLEDG 53
Query: 60 WSLADVGISFCSTLKCFVKEEDKPTLYVFNAVTQDTMPVMESISLLDKTVSDLRTLVTLR 119
+L+D I STL ++ ++V +T T+ + S T+ +++ + +
Sbjct: 54 RTLSDYNIQKESTLHLVLRLRGGMQIFV-KTLTGKTITLEVEPS---DTIENVKAKIQDK 109
Query: 120 CGLPVSVYCLRTPRGLEMYDCNTLKDYQTDIGTTLRL 156
G+P L G ++ D TL DY +TL L
Sbjct: 110 EGIPPDQQRL-IFAGKQLEDGRTLSDYNIQKESTLHL 145
Score = 39.3 bits (90), Expect = 0.009
Identities = 41/157 (26%), Positives = 71/157 (45%), Gaps = 13/157 (8%)
Query: 1 MRIFI-AFEGSFEPFDVSADETVEVVKLMIKDYFHIPLSEDKQGRRYLELMYAGAALKDS 59
M+IF+ G +V +T+E VK I+D IP + + L++AG L+D
Sbjct: 305 MQIFVKTLTGKTITLEVEPSDTIENVKAKIQDKEGIPPDQQR-------LIFAGKQLEDG 357
Query: 60 WSLADVGISFCSTLKCFVKEEDKPTLYVFNAVTQDTMPVMESISLLDKTVSDLRTLVTLR 119
+L+D I STL ++ ++V +T T+ + S T+ +++ + +
Sbjct: 358 RTLSDYNIQKESTLHLVLRLRGGMQIFV-KTLTGKTITLEVEPS---DTIENVKAKIQDK 413
Query: 120 CGLPVSVYCLRTPRGLEMYDCNTLKDYQTDIGTTLRL 156
G+P L G ++ D TL DY +TL L
Sbjct: 414 EGIPPDQQRL-IFAGKQLEDGRTLSDYNIQKESTLHL 449
Score = 39.3 bits (90), Expect = 0.009
Identities = 41/157 (26%), Positives = 71/157 (45%), Gaps = 13/157 (8%)
Query: 1 MRIFI-AFEGSFEPFDVSADETVEVVKLMIKDYFHIPLSEDKQGRRYLELMYAGAALKDS 59
M+IF+ G +V +T+E VK I+D IP + + L++AG L+D
Sbjct: 457 MQIFVKTLTGKTITLEVEPSDTIENVKAKIQDKEGIPPDQQR-------LIFAGKQLEDG 509
Query: 60 WSLADVGISFCSTLKCFVKEEDKPTLYVFNAVTQDTMPVMESISLLDKTVSDLRTLVTLR 119
+L+D I STL ++ ++V +T T+ + S T+ +++ + +
Sbjct: 510 RTLSDYNIQKESTLHLVLRLRGGMQIFV-KTLTGKTITLEVEPS---DTIENVKAKIQDK 565
Query: 120 CGLPVSVYCLRTPRGLEMYDCNTLKDYQTDIGTTLRL 156
G+P L G ++ D TL DY +TL L
Sbjct: 566 EGIPPDQQRL-IFAGKQLEDGRTLSDYNIQKESTLHL 601
Score = 32.7 bits (73), Expect = 0.87
Identities = 24/74 (32%), Positives = 37/74 (50%), Gaps = 8/74 (10%)
Query: 1 MRIFI-AFEGSFEPFDVSADETVEVVKLMIKDYFHIPLSEDKQGRRYLELMYAGAALKDS 59
M+IF+ G +V +T+E VK I+D IP + + L++AG L+D
Sbjct: 609 MQIFVKTLTGKTITLEVEPSDTIENVKAKIQDKEGIPPDQQR-------LIFAGKQLEDG 661
Query: 60 WSLADVGISFCSTL 73
+L+D I STL
Sbjct: 662 RTLSDYNIQKESTL 675
>gi|24233530 ankyrin repeat domain 44 [Homo sapiens]
Length = 919
Score = 39.3 bits (90), Expect = 0.009
Identities = 31/106 (29%), Positives = 45/106 (42%), Gaps = 16/106 (15%)
Query: 193 RVALYIAAFCGYIELTEWALKQGARPHEAVGVHPYRAWCHEALHADVSKCPIHAAAEAGQ 252
R AL +AAF G+ E E + GA V + P+HA+ G
Sbjct: 576 RTALDLAAFKGHTECVEALINPGASIFVKDNV--------------TKRTPLHASVINGH 621
Query: 253 LLILKAFVNYS--VLCLECKNAAGQTPLTIVFKHKHKDCVLYLLSK 296
L L+ + + ++ K+A GQTPL + + H D V LL K
Sbjct: 622 TLCLRLLLEIADNPEAVDVKDAKGQTPLMLAVAYGHIDAVSLLLEK 667
Score = 32.3 bits (72), Expect = 1.1
Identities = 29/105 (27%), Positives = 42/105 (40%), Gaps = 15/105 (14%)
Query: 193 RVALYIAAFCGYIELTEWALKQGARPHEAVGVHPYRAWCHEALHADVSKCPIHAAAEAGQ 252
R L AAF ++E + L+ A P AV + K + AAE GQ
Sbjct: 815 RTPLRAAAFADHVECLQLLLRHSA-PVNAVD--------------NSGKTALMMAAENGQ 859
Query: 253 LLILKAFVNYSVLCLECKNAAGQTPLTIVFKHKHKDCVLYLLSKM 297
+ VN + L K+ TPL + H+ C L +L K+
Sbjct: 860 AGAVDILVNSAQADLTVKDKDLNTPLHLACSKGHEKCALLILDKI 904
Score = 32.0 bits (71), Expect = 1.5
Identities = 38/131 (29%), Positives = 54/131 (41%), Gaps = 22/131 (16%)
Query: 193 RVALYIAAFCGYIELTEWALKQGARPHEAVGVHPYRA--WCHEALHADV----------- 239
R AL+ AA G++E+ L +GA + A RA W H DV
Sbjct: 116 RTALHHAALNGHVEMVNLLLAKGANIN-AFDKKDRRALHWAAYMGHLDVVALLINHGAEV 174
Query: 240 ------SKCPIHAAAEAGQLLILKAFVNYSVLCLECKNAAGQTPLTIVFKHKHKDCVLYL 293
P+HAAA GQ+ ++K +N V E N G T L I + +D V+
Sbjct: 175 TCKDKKGYTPLHAAASNGQINVVKHLLNLGVEIDEI-NVYGNTALHIAC-YNGQDAVVNE 232
Query: 294 LSKMWSTVSFP 304
L + V+ P
Sbjct: 233 LIDYGANVNQP 243
>gi|11024714 ubiquitin B precursor [Homo sapiens]
Length = 229
Score = 39.3 bits (90), Expect = 0.009
Identities = 41/157 (26%), Positives = 71/157 (45%), Gaps = 13/157 (8%)
Query: 1 MRIFI-AFEGSFEPFDVSADETVEVVKLMIKDYFHIPLSEDKQGRRYLELMYAGAALKDS 59
M+IF+ G +V +T+E VK I+D IP + + L++AG L+D
Sbjct: 1 MQIFVKTLTGKTITLEVEPSDTIENVKAKIQDKEGIPPDQQR-------LIFAGKQLEDG 53
Query: 60 WSLADVGISFCSTLKCFVKEEDKPTLYVFNAVTQDTMPVMESISLLDKTVSDLRTLVTLR 119
+L+D I STL ++ ++V +T T+ + S T+ +++ + +
Sbjct: 54 RTLSDYNIQKESTLHLVLRLRGGMQIFV-KTLTGKTITLEVEPS---DTIENVKAKIQDK 109
Query: 120 CGLPVSVYCLRTPRGLEMYDCNTLKDYQTDIGTTLRL 156
G+P L G ++ D TL DY +TL L
Sbjct: 110 EGIPPDQQRL-IFAGKQLEDGRTLSDYNIQKESTLHL 145
Score = 32.7 bits (73), Expect = 0.87
Identities = 24/74 (32%), Positives = 37/74 (50%), Gaps = 8/74 (10%)
Query: 1 MRIFI-AFEGSFEPFDVSADETVEVVKLMIKDYFHIPLSEDKQGRRYLELMYAGAALKDS 59
M+IF+ G +V +T+E VK I+D IP + + L++AG L+D
Sbjct: 153 MQIFVKTLTGKTITLEVEPSDTIENVKAKIQDKEGIPPDQQR-------LIFAGKQLEDG 205
Query: 60 WSLADVGISFCSTL 73
+L+D I STL
Sbjct: 206 RTLSDYNIQKESTL 219
>gi|241896857 hypothetical protein LOC100287718 [Homo sapiens]
Length = 222
Score = 37.7 bits (86), Expect = 0.027
Identities = 31/104 (29%), Positives = 44/104 (42%), Gaps = 16/104 (15%)
Query: 190 YQKRVALYIAAFCGYIELTEWALKQGARPHEAVGVHPYRAWCHEALHADVSKCPIHAAAE 249
+ R L+ AA G +E+ ++ GARP L V P H AAE
Sbjct: 68 WNDRTPLHWAAIKGQMEVIRLLIEYGARP---------------CLVTSVGWTPAHFAAE 112
Query: 250 AGQLLILKAFVNYSVLCLECKNAAGQTPLTIVFKHKHKDCVLYL 293
AG L ILK ++ ++ + G TP I + K CV +L
Sbjct: 113 AGHLNILKT-LHALHAAIDAPDFFGDTPKRIAQIYGQKACVAFL 155
>gi|239754321 PREDICTED: similar to ankyrin repeat domain 2 [Homo
sapiens]
Length = 245
Score = 37.7 bits (86), Expect = 0.027
Identities = 31/104 (29%), Positives = 44/104 (42%), Gaps = 16/104 (15%)
Query: 190 YQKRVALYIAAFCGYIELTEWALKQGARPHEAVGVHPYRAWCHEALHADVSKCPIHAAAE 249
+ R L+ AA G +E+ ++ GARP L V P H AAE
Sbjct: 91 WNDRTPLHWAAIKGQMEVIRLLIEYGARP---------------CLVTSVGWTPAHFAAE 135
Query: 250 AGQLLILKAFVNYSVLCLECKNAAGQTPLTIVFKHKHKDCVLYL 293
AG L ILK ++ ++ + G TP I + K CV +L
Sbjct: 136 AGHLNILKT-LHALHAAIDAPDFFGDTPKRIAQIYGQKACVAFL 178
>gi|224465233 euchromatic histone-lysine N-methyltransferase 1
isoform 1 [Homo sapiens]
Length = 1298
Score = 37.4 bits (85), Expect = 0.035
Identities = 29/107 (27%), Positives = 50/107 (46%), Gaps = 19/107 (17%)
Query: 192 KRVALYIAAFCGYIELTEWALKQGAR--PHEAVGVHPYRAWCHEALHADVSKCPIHAAAE 249
+R L AA ++E ++ +K GA P +A G S C +H AA+
Sbjct: 806 QRTPLMEAAENNHLEAVKYLIKAGALVDPKDAEG----------------STC-LHLAAK 848
Query: 250 AGQLLILKAFVNYSVLCLECKNAAGQTPLTIVFKHKHKDCVLYLLSK 296
G +++ ++ + + C++ G TP+ ++KH D V LLSK
Sbjct: 849 KGHYEVVQYLLSNGQMDVNCQDDGGWTPMIWATEYKHVDLVKLLLSK 895
Score = 30.4 bits (67), Expect = 4.3
Identities = 37/154 (24%), Positives = 59/154 (38%), Gaps = 25/154 (16%)
Query: 166 LMGCLLGQKLKVQRYLSKEGPVLK---YQKRVALYIAAFCGYIELTEWALKQGARPHEAV 222
LM L+ +YL K G ++ + L++AA G+ E+ ++ L G
Sbjct: 810 LMEAAENNHLEAVKYLIKAGALVDPKDAEGSTCLHLAAKKGHYEVVQYLLSNGQMDVNCQ 869
Query: 223 --GVHPYRAWCHEALHADVSKCPI-----------------HAAAEAGQLLILKAFVNYS 263
G W E H D+ K + H AA +G + I + + +
Sbjct: 870 DDGGWTPMIWATEYKHVDLVKLLLSKGSDINIRDNEENICLHWAAFSGCVDIAEILL--A 927
Query: 264 VLC-LECKNAAGQTPLTIVFKHKHKDCVLYLLSK 296
C L N G +PL I + DCV+ LS+
Sbjct: 928 AKCDLHAVNIHGDSPLHIAARENRYDCVVLFLSR 961
Score = 30.0 bits (66), Expect = 5.7
Identities = 18/54 (33%), Positives = 26/54 (48%), Gaps = 1/54 (1%)
Query: 241 KCPIHAAAEAGQLLILKAFVNYSVLCLECKNAAGQTPLTIVFKHKHKDCVLYLL 294
+ P+HAAAEAG + I V C +TPL ++ H + V YL+
Sbjct: 774 RSPLHAAAEAGHVDICHMLVQAGANIDTCSEDQ-RTPLMEAAENNHLEAVKYLI 826
>gi|148596917 fibronectin type III and ankyrin repeat domains 1
[Homo sapiens]
Length = 345
Score = 37.0 bits (84), Expect = 0.046
Identities = 39/151 (25%), Positives = 62/151 (41%), Gaps = 22/151 (14%)
Query: 151 GTTLRLDVWDGWKEFLMGCLLGQKLKVQRYLSKEGPVLKYQKR-----VALYIAAFCGYI 205
GT + L G ++ C G L V +YL + G +Q R AL+ AA G+
Sbjct: 167 GTDVNLKNGSGKDSLMLACYAGH-LDVVKYLRRHGA--SWQARDLGGCTALHWAADGGHC 223
Query: 206 ELTEWALKQGARPHEAVGVHPYRAWCHEALHADVSKCPIHAAAEAGQLLILKAFVNYSVL 265
+ EW +K G E V W + + + + L++ A N +V
Sbjct: 224 SVIEWMIKDGC---EVDVVDTGSGW------TPLMRVSAVSGNQRVASLLIDAGANVNV- 273
Query: 266 CLECKNAAGQTPLTIVFKHKHKDCVLYLLSK 296
K+ G+TPL + + H++ V LL K
Sbjct: 274 ----KDRNGKTPLMVAVLNNHEELVQLLLDK 300
>gi|157743284 ankyrin repeat domain 52 [Homo sapiens]
Length = 1076
Score = 37.0 bits (84), Expect = 0.046
Identities = 33/112 (29%), Positives = 46/112 (41%), Gaps = 16/112 (14%)
Query: 187 VLKYQKRVALYIAAFCGYIELTEWALKQGARPHEAVGVHPYRAWCHEALHADVSKCPIHA 246
V ++ R AL++A G E E GA A+ R W P+HA
Sbjct: 613 VRDHKGRTALFLATERGSTECVEVLTAHGA---SALIKERKRKWT-----------PLHA 658
Query: 247 AAEAGQLLILKAFVNYSVLC--LECKNAAGQTPLTIVFKHKHKDCVLYLLSK 296
AA +G L ++ + +A GQTPL + + H DCV LL K
Sbjct: 659 AAASGHTDSLHLLIDSGERADITDVMDAYGQTPLMLAIMNGHVDCVHLLLEK 710
>gi|156142199 euchromatic histone-lysine N-methyltransferase 2
isoform b [Homo sapiens]
Length = 1176
Score = 35.8 bits (81), Expect = 0.10
Identities = 41/156 (26%), Positives = 61/156 (39%), Gaps = 29/156 (18%)
Query: 166 LMGCLLGQKLKVQRYLSKEGPVLKYQKR----VALYIAAFCGYIELTEWALKQG---ARP 218
LM ++ L+V RY+ + G + Y K L+ AA G +E+ L G
Sbjct: 688 LMEAVVNNHLEVARYMVQRGGCV-YSKEEDGSTCLHHAAKIGNLEMVSLLLSTGQVDVNA 746
Query: 219 HEAVGVHPYRAWCHEALHADVSKCPI-----------------HAAAEAGQLLILKAFVN 261
++ G P W E H +V + + H A+ G I + +N
Sbjct: 747 QDSGGWTPI-IWAAEHKHIEVIRMLLTRGADVTLTDNEENICLHWASFTGSAAIAEVLLN 805
Query: 262 YSVLC-LECKNAAGQTPLTIVFKHKHKDCVLYLLSK 296
C L N G TPL I + + DCVL LS+
Sbjct: 806 --ARCDLHAVNYHGDTPLHIAARESYHDCVLLFLSR 839
Score = 35.0 bits (79), Expect = 0.18
Identities = 29/124 (23%), Positives = 52/124 (41%), Gaps = 20/124 (16%)
Query: 192 KRVALYIAAFCGYIELTEWALKQGARPH-------------------EAVGVHPYRAWCH 232
KR L+ AA G +E+ L+ GA + E R C
Sbjct: 651 KRTPLHAAAQKGSVEICHVLLQAGANINAVDKQQRTPLMEAVVNNHLEVARYMVQRGGCV 710
Query: 233 EALHADVSKCPIHAAAEAGQLLILKAFVNYSVLCLECKNAAGQTPLTIVFKHKHKDCVLY 292
+ D S C +H AA+ G L ++ ++ + + +++ G TP+ +HKH + +
Sbjct: 711 YSKEEDGSTC-LHHAAKIGNLEMVSLLLSTGQVDVNAQDSGGWTPIIWAAEHKHIEVIRM 769
Query: 293 LLSK 296
LL++
Sbjct: 770 LLTR 773
>gi|156142197 euchromatic histone-lysine N-methyltransferase 2
isoform a [Homo sapiens]
Length = 1210
Score = 35.8 bits (81), Expect = 0.10
Identities = 41/156 (26%), Positives = 61/156 (39%), Gaps = 29/156 (18%)
Query: 166 LMGCLLGQKLKVQRYLSKEGPVLKYQKR----VALYIAAFCGYIELTEWALKQG---ARP 218
LM ++ L+V RY+ + G + Y K L+ AA G +E+ L G
Sbjct: 722 LMEAVVNNHLEVARYMVQRGGCV-YSKEEDGSTCLHHAAKIGNLEMVSLLLSTGQVDVNA 780
Query: 219 HEAVGVHPYRAWCHEALHADVSKCPI-----------------HAAAEAGQLLILKAFVN 261
++ G P W E H +V + + H A+ G I + +N
Sbjct: 781 QDSGGWTPI-IWAAEHKHIEVIRMLLTRGADVTLTDNEENICLHWASFTGSAAIAEVLLN 839
Query: 262 YSVLC-LECKNAAGQTPLTIVFKHKHKDCVLYLLSK 296
C L N G TPL I + + DCVL LS+
Sbjct: 840 --ARCDLHAVNYHGDTPLHIAARESYHDCVLLFLSR 873
Score = 35.0 bits (79), Expect = 0.18
Identities = 29/124 (23%), Positives = 52/124 (41%), Gaps = 20/124 (16%)
Query: 192 KRVALYIAAFCGYIELTEWALKQGARPH-------------------EAVGVHPYRAWCH 232
KR L+ AA G +E+ L+ GA + E R C
Sbjct: 685 KRTPLHAAAQKGSVEICHVLLQAGANINAVDKQQRTPLMEAVVNNHLEVARYMVQRGGCV 744
Query: 233 EALHADVSKCPIHAAAEAGQLLILKAFVNYSVLCLECKNAAGQTPLTIVFKHKHKDCVLY 292
+ D S C +H AA+ G L ++ ++ + + +++ G TP+ +HKH + +
Sbjct: 745 YSKEEDGSTC-LHHAAKIGNLEMVSLLLSTGQVDVNAQDSGGWTPIIWAAEHKHIEVIRM 803
Query: 293 LLSK 296
LL++
Sbjct: 804 LLTR 807
>gi|19718741 oxysterol-binding protein-like 1A isoform B [Homo
sapiens]
Length = 950
Score = 35.4 bits (80), Expect = 0.13
Identities = 41/152 (26%), Positives = 55/152 (36%), Gaps = 21/152 (13%)
Query: 161 GWKEFLMGCLLGQKLKVQRYLSK--EGPVLKYQKRVALYIAAFCGYIELTEWALKQGARP 218
GW + C G + VQ L E VL L+ AAF G EL L+ A
Sbjct: 48 GWTPLHLACYFGHRQVVQDLLKAGAEVNVLNDMGDTPLHRAAFTGRKELVMLLLEYNA-- 105
Query: 219 HEAVGVHPYRAWCHEALHADVSKCPIHA---------------AAEAGQLLILKAFVNY- 262
+ V+ E HA+ + + A AA G+ L A +N
Sbjct: 106 -DTTIVNGSGQTAKEVTHAEEIRSMLEAVERTQQRKLEELLLAAAREGKTTELTALLNRP 164
Query: 263 SVLCLECKNAAGQTPLTIVFKHKHKDCVLYLL 294
+ + C + G TPL HK C L LL
Sbjct: 165 NPPDVNCSDQLGNTPLHCAAYRAHKQCALKLL 196
>gi|110431370 espin [Homo sapiens]
Length = 854
Score = 35.4 bits (80), Expect = 0.13
Identities = 27/101 (26%), Positives = 41/101 (40%), Gaps = 14/101 (13%)
Query: 196 LYIAAFCGYIELTEWALKQGARPHEAVGVHPYRAWCHEALHADVSKCPIHAAAEAGQLLI 255
L++AA G+ E+ W L G G P A D+ PIH AA G
Sbjct: 108 LHLAARFGHPEVVNWLLHHG-------GGDPTAA-------TDMGALPIHYAAAKGDFPS 153
Query: 256 LKAFVNYSVLCLECKNAAGQTPLTIVFKHKHKDCVLYLLSK 296
L+ V + + + G TPL + + H + YL+ +
Sbjct: 154 LRLLVEHYPEGVNAQTKNGATPLYLACQEGHLEVTQYLVQE 194
Score = 33.1 bits (74), Expect = 0.67
Identities = 25/100 (25%), Positives = 48/100 (48%), Gaps = 16/100 (16%)
Query: 196 LYIAAFCGYIELTEWALKQ-GARPHEAVGVHPYRAWCHEALHADVSKCPIHAAAEAGQLL 254
LY+A G++E+T++ +++ GA PH A H+ + P+HAAA+ G
Sbjct: 176 LYLACQEGHLEVTQYLVQECGADPH---------ARAHDGM------TPLHAAAQMGHSP 220
Query: 255 ILKAFVNYSVLCLECKNAAGQTPLTIVFKHKHKDCVLYLL 294
++ V+ + + L ++ G T + H + +LL
Sbjct: 221 VIVWLVSCTDVSLSEQDKDGATAMHFAASRGHTKVLSWLL 260
Score = 31.6 bits (70), Expect = 1.9
Identities = 19/63 (30%), Positives = 29/63 (46%)
Query: 234 ALHADVSKCPIHAAAEAGQLLILKAFVNYSVLCLECKNAAGQTPLTIVFKHKHKDCVLYL 293
+L + P+H AA AG+L L+ V + L + G TP H C+ +L
Sbjct: 30 SLRDPLDALPVHHAARAGKLHCLRFLVEEAALPAAARARNGATPAHDASATGHLACLQWL 89
Query: 294 LSK 296
LS+
Sbjct: 90 LSQ 92
>gi|188595682 ankyrin 2 isoform 3 [Homo sapiens]
Length = 1863
Score = 35.0 bits (79), Expect = 0.18
Identities = 29/120 (24%), Positives = 53/120 (44%), Gaps = 18/120 (15%)
Query: 177 VQRYLSKEGPV--LKYQKRVALYIAAFCGYIELTEWALKQGARPHEAVGVHPYRAWCHEA 234
V+ L + PV + AL++AA CG+ +T+ L + A P+ A
Sbjct: 327 VKHLLQHKAPVDDVTLDYLTALHVAAHCGHYRVTKLLLDKRANPNA------------RA 374
Query: 235 LHADVSKCPIHAAAEAGQLLILKAFVNYSVLCLECKNAAGQTPLTIVFKHKHKDCVLYLL 294
L+ P+H A + ++ +++ V Y ++ +G TP+ + H + VL LL
Sbjct: 375 LNGFT---PLHIACKKNRIKVMELLVKYGA-SIQAITESGLTPIHVAAFMGHLNIVLLLL 430
Score = 32.7 bits (73), Expect = 0.87
Identities = 30/127 (23%), Positives = 54/127 (42%), Gaps = 19/127 (14%)
Query: 174 KLKVQRYLSKEGPVLKYQKRVAL---YIAAFCGYIELTEWALKQGARPHEAVGVHPYRAW 230
++KV L K G ++ L ++AAF G++ + L+ GA P + +
Sbjct: 389 RIKVMELLVKYGASIQAITESGLTPIHVAAFMGHLNIVLLLLQNGASP-DVTNIR----- 442
Query: 231 CHEALHADVSKCPIHAAAEAGQLLILKAFVNYSVLCLECKNAAGQTPLTIVFKHKHKDCV 290
+ +H AA AGQ+ +++ + L ++ + QTPL I + + V
Sbjct: 443 ---------GETALHMAARAGQVEVVRCLLRNGAL-VDARAREEQTPLHIASRLGKTEIV 492
Query: 291 LYLLSKM 297
LL M
Sbjct: 493 QLLLQHM 499
Score = 32.7 bits (73), Expect = 0.87
Identities = 27/101 (26%), Positives = 39/101 (38%), Gaps = 16/101 (15%)
Query: 196 LYIAAFCGYIELTEWALKQGARPHEAVGVHPYRAWCHEALHADVSKCPIHAAAEAGQLLI 255
L++AA ++ L++GA PH A P+H AA+ Q+ I
Sbjct: 579 LHVAAHYDNQKVALLLLEKGASPHAT---------------AKNGYTPLHIAAKKNQMQI 623
Query: 256 LKAFVNYSVLCLECKNAAGQTPLTIVFKHKHKDCVLYLLSK 296
+NY G TPL + + H D V LL K
Sbjct: 624 ASTLLNYGAE-TNIVTKQGVTPLHLASQEGHTDMVTLLLDK 663
Score = 30.0 bits (66), Expect = 5.7
Identities = 26/100 (26%), Positives = 42/100 (42%), Gaps = 16/100 (16%)
Query: 195 ALYIAAFCGYIELTEWALKQGARPHEAVGVHPYRAWCHEALHADVSKCPIHAAAEAGQLL 254
AL++AA G++ L + L +G+ A +H A+ AGQ
Sbjct: 46 ALHLAAKEGHVGLVQELLGRGSSVDSAT---------------KKGNTALHIASLAGQAE 90
Query: 255 ILKAFVNYSVLCLECKNAAGQTPLTIVFKHKHKDCVLYLL 294
++K V + ++ G TPL + + H D V YLL
Sbjct: 91 VVKVLVKEGAN-INAQSQNGFTPLYMAAQENHIDVVKYLL 129
>gi|52426737 ankyrin 2 isoform 2 [Homo sapiens]
Length = 1872
Score = 35.0 bits (79), Expect = 0.18
Identities = 29/120 (24%), Positives = 53/120 (44%), Gaps = 18/120 (15%)
Query: 177 VQRYLSKEGPV--LKYQKRVALYIAAFCGYIELTEWALKQGARPHEAVGVHPYRAWCHEA 234
V+ L + PV + AL++AA CG+ +T+ L + A P+ A
Sbjct: 348 VKHLLQHKAPVDDVTLDYLTALHVAAHCGHYRVTKLLLDKRANPNA------------RA 395
Query: 235 LHADVSKCPIHAAAEAGQLLILKAFVNYSVLCLECKNAAGQTPLTIVFKHKHKDCVLYLL 294
L+ P+H A + ++ +++ V Y ++ +G TP+ + H + VL LL
Sbjct: 396 LNGFT---PLHIACKKNRIKVMELLVKYGA-SIQAITESGLTPIHVAAFMGHLNIVLLLL 451
Score = 32.7 bits (73), Expect = 0.87
Identities = 30/127 (23%), Positives = 54/127 (42%), Gaps = 19/127 (14%)
Query: 174 KLKVQRYLSKEGPVLKYQKRVAL---YIAAFCGYIELTEWALKQGARPHEAVGVHPYRAW 230
++KV L K G ++ L ++AAF G++ + L+ GA P + +
Sbjct: 410 RIKVMELLVKYGASIQAITESGLTPIHVAAFMGHLNIVLLLLQNGASP-DVTNIR----- 463
Query: 231 CHEALHADVSKCPIHAAAEAGQLLILKAFVNYSVLCLECKNAAGQTPLTIVFKHKHKDCV 290
+ +H AA AGQ+ +++ + L ++ + QTPL I + + V
Sbjct: 464 ---------GETALHMAARAGQVEVVRCLLRNGAL-VDARAREEQTPLHIASRLGKTEIV 513
Query: 291 LYLLSKM 297
LL M
Sbjct: 514 QLLLQHM 520
Score = 32.7 bits (73), Expect = 0.87
Identities = 27/101 (26%), Positives = 39/101 (38%), Gaps = 16/101 (15%)
Query: 196 LYIAAFCGYIELTEWALKQGARPHEAVGVHPYRAWCHEALHADVSKCPIHAAAEAGQLLI 255
L++AA ++ L++GA PH A P+H AA+ Q+ I
Sbjct: 600 LHVAAHYDNQKVALLLLEKGASPHAT---------------AKNGYTPLHIAAKKNQMQI 644
Query: 256 LKAFVNYSVLCLECKNAAGQTPLTIVFKHKHKDCVLYLLSK 296
+NY G TPL + + H D V LL K
Sbjct: 645 ASTLLNYGAE-TNIVTKQGVTPLHLASQEGHTDMVTLLLDK 684
Score = 30.0 bits (66), Expect = 5.7
Identities = 26/100 (26%), Positives = 42/100 (42%), Gaps = 16/100 (16%)
Query: 195 ALYIAAFCGYIELTEWALKQGARPHEAVGVHPYRAWCHEALHADVSKCPIHAAAEAGQLL 254
AL++AA G++ L + L +G+ A +H A+ AGQ
Sbjct: 67 ALHLAAKEGHVGLVQELLGRGSSVDSAT---------------KKGNTALHIASLAGQAE 111
Query: 255 ILKAFVNYSVLCLECKNAAGQTPLTIVFKHKHKDCVLYLL 294
++K V + ++ G TPL + + H D V YLL
Sbjct: 112 VVKVLVKEGAN-INAQSQNGFTPLYMAAQENHIDVVKYLL 150
>gi|52426735 ankyrin 2 isoform 1 [Homo sapiens]
Length = 3957
Score = 35.0 bits (79), Expect = 0.18
Identities = 29/120 (24%), Positives = 53/120 (44%), Gaps = 18/120 (15%)
Query: 177 VQRYLSKEGPV--LKYQKRVALYIAAFCGYIELTEWALKQGARPHEAVGVHPYRAWCHEA 234
V+ L + PV + AL++AA CG+ +T+ L + A P+ A
Sbjct: 348 VKHLLQHKAPVDDVTLDYLTALHVAAHCGHYRVTKLLLDKRANPNA------------RA 395
Query: 235 LHADVSKCPIHAAAEAGQLLILKAFVNYSVLCLECKNAAGQTPLTIVFKHKHKDCVLYLL 294
L+ P+H A + ++ +++ V Y ++ +G TP+ + H + VL LL
Sbjct: 396 LNGFT---PLHIACKKNRIKVMELLVKYGA-SIQAITESGLTPIHVAAFMGHLNIVLLLL 451
Score = 32.7 bits (73), Expect = 0.87
Identities = 30/127 (23%), Positives = 54/127 (42%), Gaps = 19/127 (14%)
Query: 174 KLKVQRYLSKEGPVLKYQKRVAL---YIAAFCGYIELTEWALKQGARPHEAVGVHPYRAW 230
++KV L K G ++ L ++AAF G++ + L+ GA P + +
Sbjct: 410 RIKVMELLVKYGASIQAITESGLTPIHVAAFMGHLNIVLLLLQNGASP-DVTNIR----- 463
Query: 231 CHEALHADVSKCPIHAAAEAGQLLILKAFVNYSVLCLECKNAAGQTPLTIVFKHKHKDCV 290
+ +H AA AGQ+ +++ + L ++ + QTPL I + + V
Sbjct: 464 ---------GETALHMAARAGQVEVVRCLLRNGAL-VDARAREEQTPLHIASRLGKTEIV 513
Query: 291 LYLLSKM 297
LL M
Sbjct: 514 QLLLQHM 520
Score = 32.7 bits (73), Expect = 0.87
Identities = 27/101 (26%), Positives = 39/101 (38%), Gaps = 16/101 (15%)
Query: 196 LYIAAFCGYIELTEWALKQGARPHEAVGVHPYRAWCHEALHADVSKCPIHAAAEAGQLLI 255
L++AA ++ L++GA PH A P+H AA+ Q+ I
Sbjct: 600 LHVAAHYDNQKVALLLLEKGASPHAT---------------AKNGYTPLHIAAKKNQMQI 644
Query: 256 LKAFVNYSVLCLECKNAAGQTPLTIVFKHKHKDCVLYLLSK 296
+NY G TPL + + H D V LL K
Sbjct: 645 ASTLLNYGAE-TNIVTKQGVTPLHLASQEGHTDMVTLLLDK 684
Score = 30.0 bits (66), Expect = 5.7
Identities = 26/100 (26%), Positives = 42/100 (42%), Gaps = 16/100 (16%)
Query: 195 ALYIAAFCGYIELTEWALKQGARPHEAVGVHPYRAWCHEALHADVSKCPIHAAAEAGQLL 254
AL++AA G++ L + L +G+ A +H A+ AGQ
Sbjct: 67 ALHLAAKEGHVGLVQELLGRGSSVDSAT---------------KKGNTALHIASLAGQAE 111
Query: 255 ILKAFVNYSVLCLECKNAAGQTPLTIVFKHKHKDCVLYLL 294
++K V + ++ G TPL + + H D V YLL
Sbjct: 112 VVKVLVKEGAN-INAQSQNGFTPLYMAAQENHIDVVKYLL 150
>gi|215598574 ankyrin 1 isoform 9 [Homo sapiens]
Length = 1897
Score = 35.0 bits (79), Expect = 0.18
Identities = 39/164 (23%), Positives = 69/164 (42%), Gaps = 30/164 (18%)
Query: 152 TTLRLDVWDGWKEFLMGCLLGQKLKVQRYLSKEGPVLKYQKRVALYIAAFCGYIELTEWA 211
T L + +G E ++ L +K Q ++K+G L++AA G + + E
Sbjct: 538 TPLHIAAREGHVETVLALL--EKEASQACMTKKG-------FTPLHVAAKYGKVRVAELL 588
Query: 212 LKQGARPHEAV--GVHPYRAWCHEALHADVSKC-----------------PIHAAAEAGQ 252
L++ A P+ A G+ P H + D+ K P+H AA+ Q
Sbjct: 589 LERDAHPNAAGKNGLTPLHVAVHHN-NLDIVKLLLPRGGSPHSPAWNGYTPLHIAAKQNQ 647
Query: 253 LLILKAFVNYSVLCLECKNAAGQTPLTIVFKHKHKDCVLYLLSK 296
+ + ++ + Y ++ G TPL + + H + V LLSK
Sbjct: 648 VEVARSLLQYGGSA-NAESVQGVTPLHLAAQEGHAEMVALLLSK 690
Score = 31.6 bits (70), Expect = 1.9
Identities = 29/118 (24%), Positives = 47/118 (39%), Gaps = 21/118 (17%)
Query: 196 LYIAAFCGYIELTEWALKQGARPHEAV--GVHPYRAWCHEALHADVSK------------ 241
L++AA CG+ + + L +GA+P+ G P C + H V +
Sbjct: 375 LHVAAHCGHHRVAKVLLDKGAKPNSRALNGFTPLHIACKKN-HVRVMELLLKTGASIDAV 433
Query: 242 -----CPIHAAAEAGQLLILKAFVNYSVLCLECKNAAGQTPLTIVFKHKHKDCVLYLL 294
P+H A+ G L I+K + N +TPL + + H + YLL
Sbjct: 434 TESGLTPLHVASFMGHLPIVKNLLQRGA-SPNVSNVKVETPLHMAARAGHTEVAKYLL 490
Score = 30.4 bits (67), Expect = 4.3
Identities = 17/51 (33%), Positives = 28/51 (54%), Gaps = 1/51 (1%)
Query: 244 IHAAAEAGQLLILKAFVNYSVLCLECKNAAGQTPLTIVFKHKHKDCVLYLL 294
+H AA AGQ +++ VNY + ++ G TPL + + H + V +LL
Sbjct: 115 LHIAALAGQDEVVRELVNYGA-NVNAQSQKGFTPLYMAAQENHLEVVKFLL 164
Score = 29.3 bits (64), Expect = 9.6
Identities = 15/52 (28%), Positives = 27/52 (51%), Gaps = 1/52 (1%)
Query: 243 PIHAAAEAGQLLILKAFVNYSVLCLECKNAAGQTPLTIVFKHKHKDCVLYLL 294
P+H AA G + I + +++ ++ K G +P+ + + H DCV LL
Sbjct: 308 PLHCAARNGHVRISEILLDHGAP-IQAKTKNGLSPIHMAAQGDHLDCVRLLL 358
>gi|70780359 ankyrin 1 isoform 1 [Homo sapiens]
Length = 1881
Score = 35.0 bits (79), Expect = 0.18
Identities = 39/164 (23%), Positives = 69/164 (42%), Gaps = 30/164 (18%)
Query: 152 TTLRLDVWDGWKEFLMGCLLGQKLKVQRYLSKEGPVLKYQKRVALYIAAFCGYIELTEWA 211
T L + +G E ++ L +K Q ++K+G L++AA G + + E
Sbjct: 505 TPLHIAAREGHVETVLALL--EKEASQACMTKKG-------FTPLHVAAKYGKVRVAELL 555
Query: 212 LKQGARPHEAV--GVHPYRAWCHEALHADVSKC-----------------PIHAAAEAGQ 252
L++ A P+ A G+ P H + D+ K P+H AA+ Q
Sbjct: 556 LERDAHPNAAGKNGLTPLHVAVHHN-NLDIVKLLLPRGGSPHSPAWNGYTPLHIAAKQNQ 614
Query: 253 LLILKAFVNYSVLCLECKNAAGQTPLTIVFKHKHKDCVLYLLSK 296
+ + ++ + Y ++ G TPL + + H + V LLSK
Sbjct: 615 VEVARSLLQYGGSA-NAESVQGVTPLHLAAQEGHAEMVALLLSK 657
Score = 31.6 bits (70), Expect = 1.9
Identities = 29/118 (24%), Positives = 47/118 (39%), Gaps = 21/118 (17%)
Query: 196 LYIAAFCGYIELTEWALKQGARPHEAV--GVHPYRAWCHEALHADVSK------------ 241
L++AA CG+ + + L +GA+P+ G P C + H V +
Sbjct: 342 LHVAAHCGHHRVAKVLLDKGAKPNSRALNGFTPLHIACKKN-HVRVMELLLKTGASIDAV 400
Query: 242 -----CPIHAAAEAGQLLILKAFVNYSVLCLECKNAAGQTPLTIVFKHKHKDCVLYLL 294
P+H A+ G L I+K + N +TPL + + H + YLL
Sbjct: 401 TESGLTPLHVASFMGHLPIVKNLLQRGA-SPNVSNVKVETPLHMAARAGHTEVAKYLL 457
Score = 30.4 bits (67), Expect = 4.3
Identities = 17/51 (33%), Positives = 28/51 (54%), Gaps = 1/51 (1%)
Query: 244 IHAAAEAGQLLILKAFVNYSVLCLECKNAAGQTPLTIVFKHKHKDCVLYLL 294
+H AA AGQ +++ VNY + ++ G TPL + + H + V +LL
Sbjct: 82 LHIAALAGQDEVVRELVNYGA-NVNAQSQKGFTPLYMAAQENHLEVVKFLL 131
Score = 29.3 bits (64), Expect = 9.6
Identities = 15/52 (28%), Positives = 27/52 (51%), Gaps = 1/52 (1%)
Query: 243 PIHAAAEAGQLLILKAFVNYSVLCLECKNAAGQTPLTIVFKHKHKDCVLYLL 294
P+H AA G + I + +++ ++ K G +P+ + + H DCV LL
Sbjct: 275 PLHCAARNGHVRISEILLDHGAP-IQAKTKNGLSPIHMAAQGDHLDCVRLLL 325
>gi|70780357 ankyrin 1 isoform 3 [Homo sapiens]
Length = 1880
Score = 35.0 bits (79), Expect = 0.18
Identities = 39/164 (23%), Positives = 69/164 (42%), Gaps = 30/164 (18%)
Query: 152 TTLRLDVWDGWKEFLMGCLLGQKLKVQRYLSKEGPVLKYQKRVALYIAAFCGYIELTEWA 211
T L + +G E ++ L +K Q ++K+G L++AA G + + E
Sbjct: 505 TPLHIAAREGHVETVLALL--EKEASQACMTKKG-------FTPLHVAAKYGKVRVAELL 555
Query: 212 LKQGARPHEAV--GVHPYRAWCHEALHADVSKC-----------------PIHAAAEAGQ 252
L++ A P+ A G+ P H + D+ K P+H AA+ Q
Sbjct: 556 LERDAHPNAAGKNGLTPLHVAVHHN-NLDIVKLLLPRGGSPHSPAWNGYTPLHIAAKQNQ 614
Query: 253 LLILKAFVNYSVLCLECKNAAGQTPLTIVFKHKHKDCVLYLLSK 296
+ + ++ + Y ++ G TPL + + H + V LLSK
Sbjct: 615 VEVARSLLQYGGSA-NAESVQGVTPLHLAAQEGHAEMVALLLSK 657
Score = 31.6 bits (70), Expect = 1.9
Identities = 29/118 (24%), Positives = 47/118 (39%), Gaps = 21/118 (17%)
Query: 196 LYIAAFCGYIELTEWALKQGARPHEAV--GVHPYRAWCHEALHADVSK------------ 241
L++AA CG+ + + L +GA+P+ G P C + H V +
Sbjct: 342 LHVAAHCGHHRVAKVLLDKGAKPNSRALNGFTPLHIACKKN-HVRVMELLLKTGASIDAV 400
Query: 242 -----CPIHAAAEAGQLLILKAFVNYSVLCLECKNAAGQTPLTIVFKHKHKDCVLYLL 294
P+H A+ G L I+K + N +TPL + + H + YLL
Sbjct: 401 TESGLTPLHVASFMGHLPIVKNLLQRGA-SPNVSNVKVETPLHMAARAGHTEVAKYLL 457
Score = 30.4 bits (67), Expect = 4.3
Identities = 17/51 (33%), Positives = 28/51 (54%), Gaps = 1/51 (1%)
Query: 244 IHAAAEAGQLLILKAFVNYSVLCLECKNAAGQTPLTIVFKHKHKDCVLYLL 294
+H AA AGQ +++ VNY + ++ G TPL + + H + V +LL
Sbjct: 82 LHIAALAGQDEVVRELVNYGA-NVNAQSQKGFTPLYMAAQENHLEVVKFLL 131
Score = 29.3 bits (64), Expect = 9.6
Identities = 15/52 (28%), Positives = 27/52 (51%), Gaps = 1/52 (1%)
Query: 243 PIHAAAEAGQLLILKAFVNYSVLCLECKNAAGQTPLTIVFKHKHKDCVLYLL 294
P+H AA G + I + +++ ++ K G +P+ + + H DCV LL
Sbjct: 275 PLHCAARNGHVRISEILLDHGAP-IQAKTKNGLSPIHMAAQGDHLDCVRLLL 325
>gi|70780355 ankyrin 1 isoform 2 [Homo sapiens]
Length = 1719
Score = 35.0 bits (79), Expect = 0.18
Identities = 39/164 (23%), Positives = 69/164 (42%), Gaps = 30/164 (18%)
Query: 152 TTLRLDVWDGWKEFLMGCLLGQKLKVQRYLSKEGPVLKYQKRVALYIAAFCGYIELTEWA 211
T L + +G E ++ L +K Q ++K+G L++AA G + + E
Sbjct: 505 TPLHIAAREGHVETVLALL--EKEASQACMTKKG-------FTPLHVAAKYGKVRVAELL 555
Query: 212 LKQGARPHEAV--GVHPYRAWCHEALHADVSKC-----------------PIHAAAEAGQ 252
L++ A P+ A G+ P H + D+ K P+H AA+ Q
Sbjct: 556 LERDAHPNAAGKNGLTPLHVAVHHN-NLDIVKLLLPRGGSPHSPAWNGYTPLHIAAKQNQ 614
Query: 253 LLILKAFVNYSVLCLECKNAAGQTPLTIVFKHKHKDCVLYLLSK 296
+ + ++ + Y ++ G TPL + + H + V LLSK
Sbjct: 615 VEVARSLLQYGGSA-NAESVQGVTPLHLAAQEGHAEMVALLLSK 657
Score = 31.6 bits (70), Expect = 1.9
Identities = 29/118 (24%), Positives = 47/118 (39%), Gaps = 21/118 (17%)
Query: 196 LYIAAFCGYIELTEWALKQGARPHEAV--GVHPYRAWCHEALHADVSK------------ 241
L++AA CG+ + + L +GA+P+ G P C + H V +
Sbjct: 342 LHVAAHCGHHRVAKVLLDKGAKPNSRALNGFTPLHIACKKN-HVRVMELLLKTGASIDAV 400
Query: 242 -----CPIHAAAEAGQLLILKAFVNYSVLCLECKNAAGQTPLTIVFKHKHKDCVLYLL 294
P+H A+ G L I+K + N +TPL + + H + YLL
Sbjct: 401 TESGLTPLHVASFMGHLPIVKNLLQRGA-SPNVSNVKVETPLHMAARAGHTEVAKYLL 457
Score = 30.4 bits (67), Expect = 4.3
Identities = 17/51 (33%), Positives = 28/51 (54%), Gaps = 1/51 (1%)
Query: 244 IHAAAEAGQLLILKAFVNYSVLCLECKNAAGQTPLTIVFKHKHKDCVLYLL 294
+H AA AGQ +++ VNY + ++ G TPL + + H + V +LL
Sbjct: 82 LHIAALAGQDEVVRELVNYGA-NVNAQSQKGFTPLYMAAQENHLEVVKFLL 131
Score = 29.3 bits (64), Expect = 9.6
Identities = 15/52 (28%), Positives = 27/52 (51%), Gaps = 1/52 (1%)
Query: 243 PIHAAAEAGQLLILKAFVNYSVLCLECKNAAGQTPLTIVFKHKHKDCVLYLL 294
P+H AA G + I + +++ ++ K G +P+ + + H DCV LL
Sbjct: 275 PLHCAARNGHVRISEILLDHGAP-IQAKTKNGLSPIHMAAQGDHLDCVRLLL 325
>gi|70780353 ankyrin 1 isoform 4 [Homo sapiens]
Length = 1856
Score = 35.0 bits (79), Expect = 0.18
Identities = 39/164 (23%), Positives = 69/164 (42%), Gaps = 30/164 (18%)
Query: 152 TTLRLDVWDGWKEFLMGCLLGQKLKVQRYLSKEGPVLKYQKRVALYIAAFCGYIELTEWA 211
T L + +G E ++ L +K Q ++K+G L++AA G + + E
Sbjct: 505 TPLHIAAREGHVETVLALL--EKEASQACMTKKG-------FTPLHVAAKYGKVRVAELL 555
Query: 212 LKQGARPHEAV--GVHPYRAWCHEALHADVSKC-----------------PIHAAAEAGQ 252
L++ A P+ A G+ P H + D+ K P+H AA+ Q
Sbjct: 556 LERDAHPNAAGKNGLTPLHVAVHHN-NLDIVKLLLPRGGSPHSPAWNGYTPLHIAAKQNQ 614
Query: 253 LLILKAFVNYSVLCLECKNAAGQTPLTIVFKHKHKDCVLYLLSK 296
+ + ++ + Y ++ G TPL + + H + V LLSK
Sbjct: 615 VEVARSLLQYGGSA-NAESVQGVTPLHLAAQEGHAEMVALLLSK 657
Score = 31.6 bits (70), Expect = 1.9
Identities = 29/118 (24%), Positives = 47/118 (39%), Gaps = 21/118 (17%)
Query: 196 LYIAAFCGYIELTEWALKQGARPHEAV--GVHPYRAWCHEALHADVSK------------ 241
L++AA CG+ + + L +GA+P+ G P C + H V +
Sbjct: 342 LHVAAHCGHHRVAKVLLDKGAKPNSRALNGFTPLHIACKKN-HVRVMELLLKTGASIDAV 400
Query: 242 -----CPIHAAAEAGQLLILKAFVNYSVLCLECKNAAGQTPLTIVFKHKHKDCVLYLL 294
P+H A+ G L I+K + N +TPL + + H + YLL
Sbjct: 401 TESGLTPLHVASFMGHLPIVKNLLQRGA-SPNVSNVKVETPLHMAARAGHTEVAKYLL 457
Score = 30.4 bits (67), Expect = 4.3
Identities = 17/51 (33%), Positives = 28/51 (54%), Gaps = 1/51 (1%)
Query: 244 IHAAAEAGQLLILKAFVNYSVLCLECKNAAGQTPLTIVFKHKHKDCVLYLL 294
+H AA AGQ +++ VNY + ++ G TPL + + H + V +LL
Sbjct: 82 LHIAALAGQDEVVRELVNYGA-NVNAQSQKGFTPLYMAAQENHLEVVKFLL 131
Score = 29.3 bits (64), Expect = 9.6
Identities = 15/52 (28%), Positives = 27/52 (51%), Gaps = 1/52 (1%)
Query: 243 PIHAAAEAGQLLILKAFVNYSVLCLECKNAAGQTPLTIVFKHKHKDCVLYLL 294
P+H AA G + I + +++ ++ K G +P+ + + H DCV LL
Sbjct: 275 PLHCAARNGHVRISEILLDHGAP-IQAKTKNGLSPIHMAAQGDHLDCVRLLL 325
>gi|116063534 ankyrin repeat domain 27 (VPS9 domain) [Homo sapiens]
Length = 1050
Score = 34.7 bits (78), Expect = 0.23
Identities = 25/99 (25%), Positives = 42/99 (42%), Gaps = 16/99 (16%)
Query: 196 LYIAAFCGYIELTEWALKQGARPHEAVGVHPYRAWCHEALHADVSKCPIHAAAEAGQLLI 255
L++AA CG L + + +GA + A H P+H A + G +
Sbjct: 467 LHVAAVCGQASLIDLLVSKGAMVN-ATDYH--------------GATPLHLACQKGYQSV 511
Query: 256 LKAFVNYSVLCLECKNAAGQTPLTIVFKHKHKDCVLYLL 294
++Y E ++ G TPL + + H+DCV L+
Sbjct: 512 TLLLLHYKASA-EVQDNNGNTPLHLACTYGHEDCVKALV 549
>gi|30425444 ankyrin repeat and kinase domain containing 1 [Homo
sapiens]
Length = 765
Score = 33.9 bits (76), Expect = 0.39
Identities = 33/122 (27%), Positives = 50/122 (40%), Gaps = 20/122 (16%)
Query: 193 RVALYIAAFCGYIELTEWALKQGAR-----------PHEAVGVHPYRAWCHEALHADVSK 241
+ L++AA+ G++ L + QGA H AV RA H V
Sbjct: 495 KTPLHVAAYFGHVSLVKLLTSQGAELDAQQRNLRTPLHLAVERGKVRAIQHLLKSGAVPD 554
Query: 242 C-------PIHAAAEAGQLLILKAFVNYSVLCLECKNAAGQTPLTIVFKHKHKDCVLYLL 294
P+H AA G+ LI K + Y LE G TPL + H + +++LL
Sbjct: 555 ALDQSGYGPLHTAAARGKYLICKMLLRYGA-SLELPTHQGWTPLHLAAYKGHLE-IIHLL 612
Query: 295 SK 296
++
Sbjct: 613 AE 614
>gi|38683807 ankyrin repeat domain protein 17 isoform a [Homo
sapiens]
Length = 2603
Score = 33.5 bits (75), Expect = 0.51
Identities = 35/127 (27%), Positives = 52/127 (40%), Gaps = 20/127 (15%)
Query: 172 GQKLKVQRYLSKEGPVLKYQKRVALYIAAFCGYIELTEWALKQGARPHE--AVGVHPYRA 229
G L+V +L K G ++ L AA G++EL ++ L GA H A G
Sbjct: 544 GGFLEVADFLIKAGADIELGCSTPLMEAAQEGHLELVKYLLAAGANVHATTATGDTALTY 603
Query: 230 WCHEALHADVSKCPIHAAAEAGQLLILKAFVNYSVLCLECKNAAGQTPLTIVFKHKHKDC 289
C H DV+ + A A+ LE ++ G+TPL + H
Sbjct: 604 ACENG-HTDVADVLLQAGAD-----------------LEHESEGGRTPLMKAARAGHVCT 645
Query: 290 VLYLLSK 296
V +L+SK
Sbjct: 646 VQFLISK 652
Database: hs.faa
Posted date: Aug 4, 2009 4:42 PM
Number of letters in database: 18,247,518
Number of sequences in database: 37,866
Lambda K H
0.321 0.133 0.405
Gapped
Lambda K H
0.267 0.0410 0.140
Matrix: BLOSUM62
Gap Penalties: Existence: 11, Extension: 1
Number of Hits to DB: 19,987,573
Number of Sequences: 37866
Number of extensions: 848150
Number of successful extensions: 2509
Number of sequences better than 10.0: 30
Number of HSP's better than 10.0 without gapping: 15
Number of HSP's successfully gapped in prelim test: 66
Number of HSP's that attempted gapping in prelim test: 2369
Number of HSP's gapped (non-prelim): 183
length of query: 544
length of database: 18,247,518
effective HSP length: 107
effective length of query: 437
effective length of database: 14,195,856
effective search space: 6203589072
effective search space used: 6203589072
T: 11
A: 40
X1: 16 ( 7.4 bits)
X2: 38 (14.6 bits)
X3: 64 (24.7 bits)
S1: 41 (21.9 bits)
S2: 64 (29.3 bits)
Search results were obtained with NCBI BLAST and RefSeq entries.
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Guide to the Human Genome
Copyright © 2010 by Stewart Scherer. All rights reserved.