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Search of human proteins with 221307578
BLASTP 2.2.11 [Jun-05-2005]
Reference: Altschul, Stephen F., Thomas L. Madden, Alejandro A. Schaffer,
Jinghui Zhang, Zheng Zhang, Webb Miller, and David J. Lipman (1997),
"Gapped BLAST and PSI-BLAST: a new generation of protein database search
programs", Nucleic Acids Res. 25:3389-3402.
Query= gi|221307578 RUN domain containing 3A isoform 1 [Homo sapiens]
(446 letters)
Database: hs.faa
37,866 sequences; 18,247,518 total letters
Searching..................................................done
Score E
Sequences producing significant alignments: (bits) Value
gi|221307578 RUN domain containing 3A isoform 1 [Homo sapiens] 887 0.0
gi|5730015 RUN domain containing 3A isoform 2 [Homo sapiens] 795 0.0
gi|221307580 RUN domain containing 3A isoform 3 [Homo sapiens] 778 0.0
gi|197304744 RUN domain containing 3B isoform b [Homo sapiens] 443 e-124
gi|19923090 RUN domain containing 3B isoform a [Homo sapiens] 440 e-123
gi|197304746 RUN domain containing 3B isoform c [Homo sapiens] 401 e-112
gi|195220720 RUN and FYVE domain containing 3 isoform 3 [Homo sa... 108 8e-24
gi|7662352 RUN and FYVE domain containing 3 isoform 2 [Homo sapi... 108 1e-23
gi|82697315 RUN and FYVE domain containing 3 isoform 1 [Homo sap... 108 1e-23
gi|94721336 RUN and FYVE domain-containing 1 isoform a [Homo sap... 103 3e-22
gi|94721330 RUN and FYVE domain-containing 1 isoform b [Homo sap... 101 2e-21
gi|94721332 RUN and FYVE domain-containing 1 isoform b [Homo sap... 101 2e-21
gi|109240556 RUN and FYVE domain-containing 2 isoform a [Homo sa... 97 2e-20
gi|109240552 RUN and FYVE domain-containing 2 isoform b [Homo sa... 67 3e-11
gi|116292170 RUN domain containing 2A [Homo sapiens] 50 3e-06
gi|221139728 pleckstrin homology domain containing, family M (wi... 45 1e-04
gi|122891862 DENN/MADD domain containing 5B [Homo sapiens] 43 7e-04
gi|44889475 RAB6 interacting protein 1 [Homo sapiens] 41 0.002
gi|38570149 WWC family member 3 [Homo sapiens] 40 0.004
gi|48762942 huntingtin interacting protein-1-related [Homo sapiens] 39 0.012
gi|239750456 PREDICTED: similar to KIAA0655 protein [Homo sapiens] 39 0.012
gi|41872583 Rho-associated, coiled-coil containing protein kinas... 38 0.016
gi|210032790 hypothetical protein LOC27146 [Homo sapiens] 37 0.047
gi|112421127 tripartite motif-containing 58 [Homo sapiens] 37 0.047
gi|32698688 citron [Homo sapiens] 36 0.062
gi|115496169 myosin, heavy chain 7, cardiac muscle, beta [Homo s... 36 0.081
gi|156766068 CDC42 binding protein kinase gamma (DMPK-like) [Hom... 36 0.081
gi|21735548 centrosomal protein 2 [Homo sapiens] 35 0.11
gi|24430183 outer dense fiber of sperm tails 2 isoform 2 [Homo s... 35 0.14
gi|24430181 outer dense fiber of sperm tails 2 isoform 1 [Homo s... 35 0.14
>gi|221307578 RUN domain containing 3A isoform 1 [Homo sapiens]
Length = 446
Score = 887 bits (2292), Expect = 0.0
Identities = 446/446 (100%), Positives = 446/446 (100%)
Query: 1 MEASFVQTTMALGLSSKKASSRNVAVERKNLITVCRFSVKTLLEKYTAEPIDDSSEEFVN 60
MEASFVQTTMALGLSSKKASSRNVAVERKNLITVCRFSVKTLLEKYTAEPIDDSSEEFVN
Sbjct: 1 MEASFVQTTMALGLSSKKASSRNVAVERKNLITVCRFSVKTLLEKYTAEPIDDSSEEFVN 60
Query: 61 FAAILEQILSHRFKACAPAGPVSWFSSDGQRGFWDYIRLACSKVPNNCVSSIENMENIST 120
FAAILEQILSHRFKACAPAGPVSWFSSDGQRGFWDYIRLACSKVPNNCVSSIENMENIST
Sbjct: 61 FAAILEQILSHRFKACAPAGPVSWFSSDGQRGFWDYIRLACSKVPNNCVSSIENMENIST 120
Query: 121 ARAKGRAWIRVALMEKRMSEYITTALRDTRTTRRFYDSGAIMLRDEATILTGMLIGLSAI 180
ARAKGRAWIRVALMEKRMSEYITTALRDTRTTRRFYDSGAIMLRDEATILTGMLIGLSAI
Sbjct: 121 ARAKGRAWIRVALMEKRMSEYITTALRDTRTTRRFYDSGAIMLRDEATILTGMLIGLSAI 180
Query: 181 DFSFCLKGEVLDGKTPVVIDYTPYLKFTQSYDYLTDEEERHSAESSTSEDNSPEHPYLPL 240
DFSFCLKGEVLDGKTPVVIDYTPYLKFTQSYDYLTDEEERHSAESSTSEDNSPEHPYLPL
Sbjct: 181 DFSFCLKGEVLDGKTPVVIDYTPYLKFTQSYDYLTDEEERHSAESSTSEDNSPEHPYLPL 240
Query: 241 VTDEDSWYSKWHKMEQKFRIVYAQKGYLEELVRLRESQLKDLEAENRRLQLQLEEAAAQN 300
VTDEDSWYSKWHKMEQKFRIVYAQKGYLEELVRLRESQLKDLEAENRRLQLQLEEAAAQN
Sbjct: 241 VTDEDSWYSKWHKMEQKFRIVYAQKGYLEELVRLRESQLKDLEAENRRLQLQLEEAAAQN 300
Query: 301 QREKRELEGVILELQEQLTGLIPSDHAPLAQGSKELTTPLVNQWPSLGTLNGAEGASNSK 360
QREKRELEGVILELQEQLTGLIPSDHAPLAQGSKELTTPLVNQWPSLGTLNGAEGASNSK
Sbjct: 301 QREKRELEGVILELQEQLTGLIPSDHAPLAQGSKELTTPLVNQWPSLGTLNGAEGASNSK 360
Query: 361 LYRRHSFMSTEPLSAEASLSSDSQRLGEGTRDEEPWGPIGKDPTPSMLGLCGSLASIPSC 420
LYRRHSFMSTEPLSAEASLSSDSQRLGEGTRDEEPWGPIGKDPTPSMLGLCGSLASIPSC
Sbjct: 361 LYRRHSFMSTEPLSAEASLSSDSQRLGEGTRDEEPWGPIGKDPTPSMLGLCGSLASIPSC 420
Query: 421 KSLASFKSNECLVSDSPEGSPALSPS 446
KSLASFKSNECLVSDSPEGSPALSPS
Sbjct: 421 KSLASFKSNECLVSDSPEGSPALSPS 446
>gi|5730015 RUN domain containing 3A isoform 2 [Homo sapiens]
Length = 405
Score = 795 bits (2054), Expect = 0.0
Identities = 400/400 (100%), Positives = 400/400 (100%)
Query: 1 MEASFVQTTMALGLSSKKASSRNVAVERKNLITVCRFSVKTLLEKYTAEPIDDSSEEFVN 60
MEASFVQTTMALGLSSKKASSRNVAVERKNLITVCRFSVKTLLEKYTAEPIDDSSEEFVN
Sbjct: 1 MEASFVQTTMALGLSSKKASSRNVAVERKNLITVCRFSVKTLLEKYTAEPIDDSSEEFVN 60
Query: 61 FAAILEQILSHRFKACAPAGPVSWFSSDGQRGFWDYIRLACSKVPNNCVSSIENMENIST 120
FAAILEQILSHRFKACAPAGPVSWFSSDGQRGFWDYIRLACSKVPNNCVSSIENMENIST
Sbjct: 61 FAAILEQILSHRFKACAPAGPVSWFSSDGQRGFWDYIRLACSKVPNNCVSSIENMENIST 120
Query: 121 ARAKGRAWIRVALMEKRMSEYITTALRDTRTTRRFYDSGAIMLRDEATILTGMLIGLSAI 180
ARAKGRAWIRVALMEKRMSEYITTALRDTRTTRRFYDSGAIMLRDEATILTGMLIGLSAI
Sbjct: 121 ARAKGRAWIRVALMEKRMSEYITTALRDTRTTRRFYDSGAIMLRDEATILTGMLIGLSAI 180
Query: 181 DFSFCLKGEVLDGKTPVVIDYTPYLKFTQSYDYLTDEEERHSAESSTSEDNSPEHPYLPL 240
DFSFCLKGEVLDGKTPVVIDYTPYLKFTQSYDYLTDEEERHSAESSTSEDNSPEHPYLPL
Sbjct: 181 DFSFCLKGEVLDGKTPVVIDYTPYLKFTQSYDYLTDEEERHSAESSTSEDNSPEHPYLPL 240
Query: 241 VTDEDSWYSKWHKMEQKFRIVYAQKGYLEELVRLRESQLKDLEAENRRLQLQLEEAAAQN 300
VTDEDSWYSKWHKMEQKFRIVYAQKGYLEELVRLRESQLKDLEAENRRLQLQLEEAAAQN
Sbjct: 241 VTDEDSWYSKWHKMEQKFRIVYAQKGYLEELVRLRESQLKDLEAENRRLQLQLEEAAAQN 300
Query: 301 QREKRELEGVILELQEQLTGLIPSDHAPLAQGSKELTTPLVNQWPSLGTLNGAEGASNSK 360
QREKRELEGVILELQEQLTGLIPSDHAPLAQGSKELTTPLVNQWPSLGTLNGAEGASNSK
Sbjct: 301 QREKRELEGVILELQEQLTGLIPSDHAPLAQGSKELTTPLVNQWPSLGTLNGAEGASNSK 360
Query: 361 LYRRHSFMSTEPLSAEASLSSDSQRLGEGTRDEEPWGPIG 400
LYRRHSFMSTEPLSAEASLSSDSQRLGEGTRDEEPWGPIG
Sbjct: 361 LYRRHSFMSTEPLSAEASLSSDSQRLGEGTRDEEPWGPIG 400
>gi|221307580 RUN domain containing 3A isoform 3 [Homo sapiens]
Length = 400
Score = 778 bits (2010), Expect = 0.0
Identities = 395/400 (98%), Positives = 395/400 (98%), Gaps = 5/400 (1%)
Query: 1 MEASFVQTTMALGLSSKKASSRNVAVERKNLITVCRFSVKTLLEKYTAEPIDDSSEEFVN 60
MEASFVQTTMALGLSSKKASSRNVAVERKNLITVCRFSVKTLLEKYTAEPIDDSSEEFVN
Sbjct: 1 MEASFVQTTMALGLSSKKASSRNVAVERKNLITVCRFSVKTLLEKYTAEPIDDSSEEFVN 60
Query: 61 FAAILEQILSHRFKACAPAGPVSWFSSDGQRGFWDYIRLACSKVPNNCVSSIENMENIST 120
FAAILEQILSHRFK GPVSWFSSDGQRGFWDYIRLACSKVPNNCVSSIENMENIST
Sbjct: 61 FAAILEQILSHRFK-----GPVSWFSSDGQRGFWDYIRLACSKVPNNCVSSIENMENIST 115
Query: 121 ARAKGRAWIRVALMEKRMSEYITTALRDTRTTRRFYDSGAIMLRDEATILTGMLIGLSAI 180
ARAKGRAWIRVALMEKRMSEYITTALRDTRTTRRFYDSGAIMLRDEATILTGMLIGLSAI
Sbjct: 116 ARAKGRAWIRVALMEKRMSEYITTALRDTRTTRRFYDSGAIMLRDEATILTGMLIGLSAI 175
Query: 181 DFSFCLKGEVLDGKTPVVIDYTPYLKFTQSYDYLTDEEERHSAESSTSEDNSPEHPYLPL 240
DFSFCLKGEVLDGKTPVVIDYTPYLKFTQSYDYLTDEEERHSAESSTSEDNSPEHPYLPL
Sbjct: 176 DFSFCLKGEVLDGKTPVVIDYTPYLKFTQSYDYLTDEEERHSAESSTSEDNSPEHPYLPL 235
Query: 241 VTDEDSWYSKWHKMEQKFRIVYAQKGYLEELVRLRESQLKDLEAENRRLQLQLEEAAAQN 300
VTDEDSWYSKWHKMEQKFRIVYAQKGYLEELVRLRESQLKDLEAENRRLQLQLEEAAAQN
Sbjct: 236 VTDEDSWYSKWHKMEQKFRIVYAQKGYLEELVRLRESQLKDLEAENRRLQLQLEEAAAQN 295
Query: 301 QREKRELEGVILELQEQLTGLIPSDHAPLAQGSKELTTPLVNQWPSLGTLNGAEGASNSK 360
QREKRELEGVILELQEQLTGLIPSDHAPLAQGSKELTTPLVNQWPSLGTLNGAEGASNSK
Sbjct: 296 QREKRELEGVILELQEQLTGLIPSDHAPLAQGSKELTTPLVNQWPSLGTLNGAEGASNSK 355
Query: 361 LYRRHSFMSTEPLSAEASLSSDSQRLGEGTRDEEPWGPIG 400
LYRRHSFMSTEPLSAEASLSSDSQRLGEGTRDEEPWGPIG
Sbjct: 356 LYRRHSFMSTEPLSAEASLSSDSQRLGEGTRDEEPWGPIG 395
>gi|197304744 RUN domain containing 3B isoform b [Homo sapiens]
Length = 456
Score = 443 bits (1140), Expect = e-124
Identities = 244/448 (54%), Positives = 316/448 (70%), Gaps = 23/448 (5%)
Query: 13 GLSSKKASSRNVAVERKNLITVCRFSVKTLLEKYTAEPIDDSSEEFVNFAAILEQILSHR 72
G K S+RN AVER+NLITVCRFSVKTL+++ E IDDSS EF NFAAILEQILSHR
Sbjct: 18 GGGKKSLSARNAAVERRNLITVCRFSVKTLIDRSCFETIDDSSPEFNNFAAILEQILSHR 77
Query: 73 FKACAPAGPVSWFSSDGQRGFWDYIRLACSKVPNNCVSSIENMENISTARAKGRAWIRVA 132
K G V+WF + R FWDYIR+AC KV NC+ SIENMEN+S++RAKGRAWIRVA
Sbjct: 78 LK-----GQVTWFGYESPRSFWDYIRVACRKVSQNCICSIENMENVSSSRAKGRAWIRVA 132
Query: 133 LMEKRMSEYITTALRDTRTTRRFYDSGAIMLRDEATILTGMLIGLSAIDFSFCLKGEVLD 192
LMEK +SEYI+TALRD +TTRRFY+ GAI+L +EA +L GML+GL+AIDFSFCLKGE LD
Sbjct: 133 LMEKHLSEYISTALRDFKTTRRFYEDGAIVLGEEANMLAGMLLGLNAIDFSFCLKGEGLD 192
Query: 193 GKTPVVIDYTPYLKFTQSYDYL-TDEEERHSAESSTSEDNSPEHPYLPLVTDEDSWYSKW 251
G P VIDYTPYLK+ QS D + +DEEE + SS SE ++PE+ P + DE+SW++K
Sbjct: 193 GSFPAVIDYTPYLKYIQSSDSISSDEEELRTLGSSGSESSTPENVGPPFLMDENSWFNKC 252
Query: 252 HKMEQKFRIVYAQKGYLEELVRLRESQLKDLEAENRRLQLQLEEAAAQNQREKRELEGVI 311
+++QK+++ QKGYLEEL+RLRE+QL + ++N+ L ++E++ ++ EK +LE +I
Sbjct: 253 KRVKQKYQLTLEQKGYLEELLRLRENQLSESVSQNKILLQRIEDSDLAHKLEKEQLEYII 312
Query: 312 LELQEQLTGLIPSDHAPLAQGSKELTTPLVNQWPSLGTLNGAEGASNSKLYRRH------ 365
+ELQ+QLT L +D + +ELT L NQWPS G L+ A ++ LYR+H
Sbjct: 313 VELQDQLTVLKNND----LRSRQELTAHLTNQWPSPGALDVNAVALDTLLYRKHNKQWYE 368
Query: 366 -SFMSTEPLSAEASLSSDS-----QRLGEGTRDEEPWGPIGKDPTPSMLGLCGSLASIPS 419
S+ S + LSAE SLS S + G+G +D GK+ TPS+LGLCGSL S+ S
Sbjct: 369 KSYQSLDQLSAEVSLSQTSLDPGQSQEGDGKQDTLNVMSEGKEDTPSLLGLCGSLTSVAS 428
Query: 420 CKSLASFKSNECLVSDSPE-GSPALSPS 446
KSL S KSN+ L S + E SP L+PS
Sbjct: 429 YKSLTSLKSNDYLASPTTEMTSPGLTPS 456
>gi|19923090 RUN domain containing 3B isoform a [Homo sapiens]
Length = 473
Score = 440 bits (1132), Expect = e-123
Identities = 244/460 (53%), Positives = 318/460 (69%), Gaps = 30/460 (6%)
Query: 13 GLSSKKASSRNVAVERKNLITVCRFSVKTLLEKYTAEPIDDSSEEFVNFAAILEQILSHR 72
G K S+RN AVER+NLITVCRFSVKTL+++ E IDDSS EF NFAAILEQILSHR
Sbjct: 18 GGGKKSLSARNAAVERRNLITVCRFSVKTLIDRSCFETIDDSSPEFNNFAAILEQILSHR 77
Query: 73 FKACAPA------------GPVSWFSSDGQRGFWDYIRLACSKVPNNCVSSIENMENIST 120
K + + G V+WF + R FWDYIR+AC KV NC+ SIENMEN+S+
Sbjct: 78 LKEISQSCRWLAHLQIPLQGQVTWFGYESPRSFWDYIRVACRKVSQNCICSIENMENVSS 137
Query: 121 ARAKGRAWIRVALMEKRMSEYITTALRDTRTTRRFYDSGAIMLRDEATILTGMLIGLSAI 180
+RAKGRAWIRVALMEK +SEYI+TALRD +TTRRFY+ GAI+L +EA +L GML+GL+AI
Sbjct: 138 SRAKGRAWIRVALMEKHLSEYISTALRDFKTTRRFYEDGAIVLGEEANMLAGMLLGLNAI 197
Query: 181 DFSFCLKGEVLDGKTPVVIDYTPYLKFTQSYDYL-TDEEERHSAESSTSEDNSPEHPYLP 239
DFSFCLKGE LDG P VIDYTPYLK+ QS D + +DEEE + SS SE ++PE+ P
Sbjct: 198 DFSFCLKGEGLDGSFPAVIDYTPYLKYIQSSDSISSDEEELRTLGSSGSESSTPENVGPP 257
Query: 240 LVTDEDSWYSKWHKMEQKFRIVYAQKGYLEELVRLRESQLKDLEAENRRLQLQLEEAAAQ 299
+ DE+SW++K +++QK+++ QKGYLEEL+RLRE+QL + ++N+ L ++E++
Sbjct: 258 FLMDENSWFNKCKRVKQKYQLTLEQKGYLEELLRLRENQLSESVSQNKILLQRIEDSDLA 317
Query: 300 NQREKRELEGVILELQEQLTGLIPSDHAPLAQGSKELTTPLVNQWPSLGTLNGAEGASNS 359
++ EK +LE +I+ELQ+QLT L +D + +ELT L NQWPS G L+ A ++
Sbjct: 318 HKLEKEQLEYIIVELQDQLTVLKNND----LRSRQELTAHLTNQWPSPGALDVNAVALDT 373
Query: 360 KLYRRH-------SFMSTEPLSAEASLSSDS-----QRLGEGTRDEEPWGPIGKDPTPSM 407
LYR+H S+ S + LSAE SLS S + G+G +D GK+ TPS+
Sbjct: 374 LLYRKHNKQWYEKSYQSLDQLSAEVSLSQTSLDPGQSQEGDGKQDTLNVMSEGKEDTPSL 433
Query: 408 LGLCGSLASIPSCKSLASFKSNECLVSDSPE-GSPALSPS 446
LGLCGSL S+ S KSL S KSN+ L S + E SP L+PS
Sbjct: 434 LGLCGSLTSVASYKSLTSLKSNDYLASPTTEMTSPGLTPS 473
>gi|197304746 RUN domain containing 3B isoform c [Homo sapiens]
Length = 407
Score = 401 bits (1031), Expect = e-112
Identities = 225/441 (51%), Positives = 290/441 (65%), Gaps = 58/441 (13%)
Query: 13 GLSSKKASSRNVAVERKNLITVCRFSVKTLLEKYTAEPIDDSSEEFVNFAAILEQILSHR 72
G K S+RN AVER+NLITVCRFSVKTL+++ E IDDSS EF NFAAILEQILSHR
Sbjct: 18 GGGKKSLSARNAAVERRNLITVCRFSVKTLIDRSCFETIDDSSPEFNNFAAILEQILSHR 77
Query: 73 FKACAPAGPVSWFSSDGQRGFWDYIRLACSKVPNNCVSSIENMENISTARAKGRAWIRVA 132
K G V+WF + R FWDYIR+AC KV NC+ SIENMEN+S++RAKGRAWIRVA
Sbjct: 78 LK-----GQVTWFGYESPRSFWDYIRVACRKVSQNCICSIENMENVSSSRAKGRAWIRVA 132
Query: 133 LMEKRMSEYITTALRDTRTTRRFYDSGAIMLRDEATILTGMLIGLSAIDFSFCLKGEVLD 192
LMEK +SEYI+TALRD +TTRRFY+ GAI+L +EA +L GML+GL+AIDFSFCLKGE LD
Sbjct: 133 LMEKHLSEYISTALRDFKTTRRFYEDGAIVLGEEANMLAGMLLGLNAIDFSFCLKGEGLD 192
Query: 193 GKTPVVIDYTPYLKFTQSYDYL-TDEEERHSAESSTSEDNSPEHPYLPLVTDEDSWYSKW 251
G P VIDYTPYLK+ QS D + +DEEE + SS SE ++PE+ P + DE+SW++K
Sbjct: 193 GSFPAVIDYTPYLKYIQSSDSISSDEEELRTLGSSGSESSTPENVGPPFLMDENSWFNKC 252
Query: 252 HKMEQKFRIVYAQKGYLEELVRLRESQLKDLEAENRRLQLQLEEAAAQNQREKRELEGVI 311
+++QK+++ QKGYLEEL+RLRE+QL + ++N+ L ++E++ ++ EK +LE +I
Sbjct: 253 KRVKQKYQLTLEQKGYLEELLRLRENQLSESVSQNKILLQRIEDSDLAHKLEKEQLEYII 312
Query: 312 LELQEQLTGLIPSDHAPLAQGSKELTTPLVNQWPSLGTLNGAEGASNSKLYRRHSFMSTE 371
+ELQ+QL S+ S +
Sbjct: 313 VELQDQL----------------------------------------------KSYQSLD 326
Query: 372 PLSAEASLSSDS-----QRLGEGTRDEEPWGPIGKDPTPSMLGLCGSLASIPSCKSLASF 426
LSAE SLS S + G+G +D GK+ TPS+LGLCGSL S+ S KSL S
Sbjct: 327 QLSAEVSLSQTSLDPGQSQEGDGKQDTLNVMSEGKEDTPSLLGLCGSLTSVASYKSLTSL 386
Query: 427 KSNECLVSDSPE-GSPALSPS 446
KSN+ L S + E SP L+PS
Sbjct: 387 KSNDYLASPTTEMTSPGLTPS 407
>gi|195220720 RUN and FYVE domain containing 3 isoform 3 [Homo
sapiens]
Length = 506
Score = 108 bits (271), Expect = 8e-24
Identities = 86/313 (27%), Positives = 140/313 (44%), Gaps = 64/313 (20%)
Query: 15 SSKKASSRNVAVERKNLITVCRFSVKTLLEKYT--AEPIDDSSEEFVNFAAILEQILSHR 72
S K + +A ER NL+ + + S+K L+E +D F ++E L H
Sbjct: 116 SGKHHPNYLMANERMNLMNMAKLSIKGLIESALNLGRTLDSDYAPLQQFFVVMEHCLKHG 175
Query: 73 FKACAPAGPVSWFSSDGQ-RGFWDYIRLACSKVPN--NCVSSIENMENISTARAKGRAWI 129
KA + GQ + FW + L VP +S++++ + T +GRAW+
Sbjct: 176 LKAKK--------TFLGQNKSFWGPLELVEKLVPEAAEITASVKDLPGLKTPVGRGRAWL 227
Query: 130 RVALMEKRMSEYITTALRDTRTTRRFYDSGAIMLRDEATILTGMLIGLSAIDFSFCLKGE 189
R+ALM+K++SEY+ + FY+ A+M+ +E I+ G+L+GL+ ID +FC+KGE
Sbjct: 228 RLALMQKKLSEYMKALINKKELLSEFYEPNALMMEEEGAIIAGLLVGLNVIDANFCMKGE 287
Query: 190 VLDGKTPVVIDYTPYLKFTQSYDYLTDEEERHSAESSTSEDNSPEHPYLPLVTDEDSWYS 249
LD + VID++ YLK D S
Sbjct: 288 DLDSQVG-VIDFSMYLK--------------------------------------DGNSS 308
Query: 250 KWHKMEQKFRIVYAQKGYLEELVRLRESQLKDLEAENRRLQLQ----LEEAAAQNQREKR 305
K + + + + QK Y+EEL R + + +L+A+ L+ EE A N R
Sbjct: 309 KGTEGDGQITAILDQKNYVEELNRHLNATVNNLQAKVDALEKSNTKLTEELAVANNR--- 365
Query: 306 ELEGVILELQEQL 318
I+ LQE++
Sbjct: 366 -----IITLQEEM 373
>gi|7662352 RUN and FYVE domain containing 3 isoform 2 [Homo
sapiens]
Length = 469
Score = 108 bits (270), Expect = 1e-23
Identities = 84/304 (27%), Positives = 137/304 (45%), Gaps = 64/304 (21%)
Query: 24 VAVERKNLITVCRFSVKTLLEKYT--AEPIDDSSEEFVNFAAILEQILSHRFKACAPAGP 81
+A ER NL+ + + S+K L+E +D F ++E L H KA
Sbjct: 65 MANERMNLMNMAKLSIKGLIESALNLGRTLDSDYAPLQQFFVVMEHCLKHGLKAKK---- 120
Query: 82 VSWFSSDGQ-RGFWDYIRLACSKVPN--NCVSSIENMENISTARAKGRAWIRVALMEKRM 138
+ GQ + FW + L VP +S++++ + T +GRAW+R+ALM+K++
Sbjct: 121 ----TFLGQNKSFWGPLELVEKLVPEAAEITASVKDLPGLKTPVGRGRAWLRLALMQKKL 176
Query: 139 SEYITTALRDTRTTRRFYDSGAIMLRDEATILTGMLIGLSAIDFSFCLKGEVLDGKTPVV 198
SEY+ + FY+ A+M+ +E I+ G+L+GL+ ID +FC+KGE LD + V
Sbjct: 177 SEYMKALINKKELLSEFYEPNALMMEEEGAIIAGLLVGLNVIDANFCMKGEDLDSQVG-V 235
Query: 199 IDYTPYLKFTQSYDYLTDEEERHSAESSTSEDNSPEHPYLPLVTDEDSWYSKWHKMEQKF 258
ID++ YLK D SK + + +
Sbjct: 236 IDFSMYLK--------------------------------------DGNSSKGTEGDGQI 257
Query: 259 RIVYAQKGYLEELVRLRESQLKDLEAENRRLQLQ----LEEAAAQNQREKRELEGVILEL 314
+ QK Y+EEL R + + +L+A+ L+ EE A N R I+ L
Sbjct: 258 TAILDQKNYVEELNRHLNATVNNLQAKVDALEKSNTKLTEELAVANNR--------IITL 309
Query: 315 QEQL 318
QE++
Sbjct: 310 QEEM 313
>gi|82697315 RUN and FYVE domain containing 3 isoform 1 [Homo
sapiens]
Length = 620
Score = 108 bits (270), Expect = 1e-23
Identities = 84/304 (27%), Positives = 137/304 (45%), Gaps = 64/304 (21%)
Query: 24 VAVERKNLITVCRFSVKTLLEKYT--AEPIDDSSEEFVNFAAILEQILSHRFKACAPAGP 81
+A ER NL+ + + S+K L+E +D F ++E L H KA
Sbjct: 65 MANERMNLMNMAKLSIKGLIESALNLGRTLDSDYAPLQQFFVVMEHCLKHGLKAKK---- 120
Query: 82 VSWFSSDGQ-RGFWDYIRLACSKVPN--NCVSSIENMENISTARAKGRAWIRVALMEKRM 138
+ GQ + FW + L VP +S++++ + T +GRAW+R+ALM+K++
Sbjct: 121 ----TFLGQNKSFWGPLELVEKLVPEAAEITASVKDLPGLKTPVGRGRAWLRLALMQKKL 176
Query: 139 SEYITTALRDTRTTRRFYDSGAIMLRDEATILTGMLIGLSAIDFSFCLKGEVLDGKTPVV 198
SEY+ + FY+ A+M+ +E I+ G+L+GL+ ID +FC+KGE LD + V
Sbjct: 177 SEYMKALINKKELLSEFYEPNALMMEEEGAIIAGLLVGLNVIDANFCMKGEDLDSQVG-V 235
Query: 199 IDYTPYLKFTQSYDYLTDEEERHSAESSTSEDNSPEHPYLPLVTDEDSWYSKWHKMEQKF 258
ID++ YLK D SK + + +
Sbjct: 236 IDFSMYLK--------------------------------------DGNSSKGTEGDGQI 257
Query: 259 RIVYAQKGYLEELVRLRESQLKDLEAENRRLQLQ----LEEAAAQNQREKRELEGVILEL 314
+ QK Y+EEL R + + +L+A+ L+ EE A N R I+ L
Sbjct: 258 TAILDQKNYVEELNRHLNATVNNLQAKVDALEKSNTKLTEELAVANNR--------IITL 309
Query: 315 QEQL 318
QE++
Sbjct: 310 QEEM 313
>gi|94721336 RUN and FYVE domain-containing 1 isoform a [Homo
sapiens]
Length = 708
Score = 103 bits (257), Expect = 3e-22
Identities = 85/329 (25%), Positives = 146/329 (44%), Gaps = 65/329 (19%)
Query: 15 SSKKASSRNVAVERKNLITVCRFSVKTLLEKYTA--EPIDDSSEEFVNFAAILEQILSHR 72
+++ AS + ER NL+ + + S+K LL+ + +D F ++E L H
Sbjct: 100 TARAASKCQMMEERANLMHMMKLSIKVLLQSALSLGRSLDADHAPLQQFFVVMEHCLKHG 159
Query: 73 FKACAPAGPVSWFSSDGQ-RGFWDYIRLACSKVP--NNCVSSIENMENISTARAKGRAWI 129
K S GQ + F+ + L P ++ +S+ N+ + TA +GRAW+
Sbjct: 160 LKVKK--------SFIGQNKSFFGPLELVEKLCPEASDIATSVRNLPELKTAVGRGRAWL 211
Query: 130 RVALMEKRMSEYITTALRDTRTTRRFYDSGAIMLRDEATILTGMLIGLSAIDFSFCLKGE 189
+ALM+K++++Y+ + + FY+ A+M+ +E ++ G+L+GL+ +D + CLKGE
Sbjct: 212 YLALMQKKLADYLKVLIDNKHLLSEFYEPEALMMEEEGMVIVGLLVGLNVLDANLCLKGE 271
Query: 190 VLDGKTPVVIDYTPYLKFTQSYDYLTDEEERHSAESSTSEDNSPEHPYLPLVTDEDSWYS 249
LD + VID++ YLK Q D EH + V D
Sbjct: 272 DLDSQVG-VIDFSLYLKDVQDL------------------DGGKEHERITDVLD------ 306
Query: 250 KWHKMEQKFRIVYAQKGYLEELVRL-------RESQLKDLEAENRRLQLQLEEAA----- 297
QK Y+EEL R ++++ LE N +LQ +L A
Sbjct: 307 --------------QKNYVEELNRHLSCTVGDLQTKIDGLEKTNSKLQEELSAATDRICS 352
Query: 298 -AQNQREKRELEGVILELQEQLTGLIPSD 325
+ Q++ RE +I E E+ + D
Sbjct: 353 LQEEQQQLREQNELIRERSEKSVEITKQD 381
>gi|94721330 RUN and FYVE domain-containing 1 isoform b [Homo
sapiens]
Length = 600
Score = 101 bits (251), Expect = 2e-21
Identities = 83/317 (26%), Positives = 140/317 (44%), Gaps = 65/317 (20%)
Query: 27 ERKNLITVCRFSVKTLLEKYTA--EPIDDSSEEFVNFAAILEQILSHRFKACAPAGPVSW 84
ER NL+ + + S+K LL+ + +D F ++E L H K
Sbjct: 4 ERANLMHMMKLSIKVLLQSALSLGRSLDADHAPLQQFFVVMEHCLKHGLKVKK------- 56
Query: 85 FSSDGQ-RGFWDYIRLACSKVP--NNCVSSIENMENISTARAKGRAWIRVALMEKRMSEY 141
S GQ + F+ + L P ++ +S+ N+ + TA +GRAW+ +ALM+K++++Y
Sbjct: 57 -SFIGQNKSFFGPLELVEKLCPEASDIATSVRNLPELKTAVGRGRAWLYLALMQKKLADY 115
Query: 142 ITTALRDTRTTRRFYDSGAIMLRDEATILTGMLIGLSAIDFSFCLKGEVLDGKTPVVIDY 201
+ + + FY+ A+M+ +E ++ G+L+GL+ +D + CLKGE LD + VID+
Sbjct: 116 LKVLIDNKHLLSEFYEPEALMMEEEGMVIVGLLVGLNVLDANLCLKGEDLDSQVG-VIDF 174
Query: 202 TPYLKFTQSYDYLTDEEERHSAESSTSEDNSPEHPYLPLVTDEDSWYSKWHKMEQKFRIV 261
+ YLK Q D EH + V D
Sbjct: 175 SLYLKDVQDL------------------DGGKEHERITDVLD------------------ 198
Query: 262 YAQKGYLEELVRL-------RESQLKDLEAENRRLQLQLEEAA------AQNQREKRELE 308
QK Y+EEL R ++++ LE N +LQ +L A + Q++ RE
Sbjct: 199 --QKNYVEELNRHLSCTVGDLQTKIDGLEKTNSKLQEELSAATDRICSLQEEQQQLREQN 256
Query: 309 GVILELQEQLTGLIPSD 325
+I E E+ + D
Sbjct: 257 ELIRERSEKSVEITKQD 273
>gi|94721332 RUN and FYVE domain-containing 1 isoform b [Homo
sapiens]
Length = 600
Score = 101 bits (251), Expect = 2e-21
Identities = 83/317 (26%), Positives = 140/317 (44%), Gaps = 65/317 (20%)
Query: 27 ERKNLITVCRFSVKTLLEKYTA--EPIDDSSEEFVNFAAILEQILSHRFKACAPAGPVSW 84
ER NL+ + + S+K LL+ + +D F ++E L H K
Sbjct: 4 ERANLMHMMKLSIKVLLQSALSLGRSLDADHAPLQQFFVVMEHCLKHGLKVKK------- 56
Query: 85 FSSDGQ-RGFWDYIRLACSKVP--NNCVSSIENMENISTARAKGRAWIRVALMEKRMSEY 141
S GQ + F+ + L P ++ +S+ N+ + TA +GRAW+ +ALM+K++++Y
Sbjct: 57 -SFIGQNKSFFGPLELVEKLCPEASDIATSVRNLPELKTAVGRGRAWLYLALMQKKLADY 115
Query: 142 ITTALRDTRTTRRFYDSGAIMLRDEATILTGMLIGLSAIDFSFCLKGEVLDGKTPVVIDY 201
+ + + FY+ A+M+ +E ++ G+L+GL+ +D + CLKGE LD + VID+
Sbjct: 116 LKVLIDNKHLLSEFYEPEALMMEEEGMVIVGLLVGLNVLDANLCLKGEDLDSQVG-VIDF 174
Query: 202 TPYLKFTQSYDYLTDEEERHSAESSTSEDNSPEHPYLPLVTDEDSWYSKWHKMEQKFRIV 261
+ YLK Q D EH + V D
Sbjct: 175 SLYLKDVQDL------------------DGGKEHERITDVLD------------------ 198
Query: 262 YAQKGYLEELVRL-------RESQLKDLEAENRRLQLQLEEAA------AQNQREKRELE 308
QK Y+EEL R ++++ LE N +LQ +L A + Q++ RE
Sbjct: 199 --QKNYVEELNRHLSCTVGDLQTKIDGLEKTNSKLQEELSAATDRICSLQEEQQQLREQN 256
Query: 309 GVILELQEQLTGLIPSD 325
+I E E+ + D
Sbjct: 257 ELIRERSEKSVEITKQD 273
>gi|109240556 RUN and FYVE domain-containing 2 isoform a [Homo
sapiens]
Length = 641
Score = 97.4 bits (241), Expect = 2e-20
Identities = 72/276 (26%), Positives = 134/276 (48%), Gaps = 22/276 (7%)
Query: 19 ASSRNVAVERKNLITVCRFSVKTLLEKYTA--EPIDDSSEEFVNFAAILEQILSHRFKAC 76
A+ AVER NL+ + + S+K L+E + +D F ++E L H K
Sbjct: 37 ATKDPTAVERANLLNMAKLSIKGLIESALSFGRTLDSDYPPLQQFFVVMEHCLKHGLKVR 96
Query: 77 APAGPVSWFSSDGQRGFWDYIRLACSKVPN--NCVSSIENMENISTARAKGRAWIRVALM 134
S+ S + + W + L P +S+ ++ + T + RAW+R+ALM
Sbjct: 97 K-----SFLSYN--KTIWGPLELVEKLYPEAEEIGASVRDLPGLKTPLGRARAWLRLALM 149
Query: 135 EKRMSEYITTALRDTRTTRRFYDSGAIMLRDEATILTGMLIGLSAIDFSFCLKGEVLDGK 194
+K+M++Y+ + FY+ A+M+ +E ++ G+L+GL+ ID + C+KGE LD +
Sbjct: 150 QKKMADYLRCLIIQRDLLSEFYEYHALMMEEEGAVIVGLLVGLNVIDANLCVKGEDLDSQ 209
Query: 195 TPVVIDYTPYLKFTQSYDYLTDEEERHSAESSTSEDNSPEHPYLPLVTDEDSWYSKWHKM 254
VID++ YLK + + + ++E + + N E L + S +S+ +
Sbjct: 210 VG-VIDFSMYLK---NEEDIGNKERNVQIAAILDQKNYVEELNRQLNSTVSSLHSRVDSL 265
Query: 255 EQKFRIVYAQKGYLEELVRLRESQLKDLEAENRRLQ 290
E+ + +EEL + + +K L+ EN +L+
Sbjct: 266 EK------SNTKLIEELAIAKNNIIK-LQEENHQLR 294
>gi|109240552 RUN and FYVE domain-containing 2 isoform b [Homo
sapiens]
Length = 403
Score = 67.0 bits (162), Expect = 3e-11
Identities = 65/276 (23%), Positives = 117/276 (42%), Gaps = 56/276 (20%)
Query: 19 ASSRNVAVERKNLITVCRFSVKTLLEKYTA--EPIDDSSEEFVNFAAILEQILSHRFKAC 76
A+ AVER NL+ + + S+K L+E + +D F ++E L H K
Sbjct: 2 ATKDPTAVERANLLNMAKLSIKGLIESALSFGRTLDSDYPPLQQFFVVMEHCLKHGLKV- 60
Query: 77 APAGPVSWFSSDGQRGFWDYIRLACSKVPNNCVSSIENMENISTARAKGRAWIRVALMEK 136
++ F Y + W + L+EK
Sbjct: 61 -------------RKSFLSYNKTI---------------------------WGPLELVEK 80
Query: 137 RM--SEYITTALRDTRTTRRFYDSGAIMLRDEATILTGMLIGLSAIDFSFCLKGEVLDGK 194
+E I ++RD FY+ A+M+ +E ++ G+L+GL+ ID + C+KGE LD +
Sbjct: 81 LYPEAEEIGASVRDLPGLNEFYEYHALMMEEEGAVIVGLLVGLNVIDANLCVKGEDLDSQ 140
Query: 195 TPVVIDYTPYLKFTQSYDYLTDEEERHSAESSTSEDNSPEHPYLPLVTDEDSWYSKWHKM 254
VID++ YLK + + + ++E + + N E L + S +S+ +
Sbjct: 141 VG-VIDFSMYLK---NEEDIGNKERNVQIAAILDQKNYVEELNRQLNSTVSSLHSRVDSL 196
Query: 255 EQKFRIVYAQKGYLEELVRLRESQLKDLEAENRRLQ 290
E+ + +EEL + + +K L+ EN +L+
Sbjct: 197 EK------SNTKLIEELAIAKNNIIK-LQEENHQLR 225
>gi|116292170 RUN domain containing 2A [Homo sapiens]
Length = 375
Score = 50.4 bits (119), Expect = 3e-06
Identities = 59/231 (25%), Positives = 99/231 (42%), Gaps = 26/231 (11%)
Query: 49 EPIDDSSEEFVNFAAILEQILSHRFK-------ACAPAGPVSWFSS--DGQRGFWDYIRL 99
E DS A E +L H K A + F+S + + FW Y++
Sbjct: 33 EIASDSDSRVTCLCAQFEAVLQHGLKRSRGLALTAAAIKQAAGFASKTETEPVFWYYVKE 92
Query: 100 ACSKVPNNCVSSIENMENISTARAKGRAWIRVALMEKRMSEYITTALRDTRTTRRFYDSG 159
+K + + ++ +I++ +GRAW+R AL E + Y+ L D FY+
Sbjct: 93 VLNK---HELQRFYSLRHIASDVGRGRAWLRCALNEHSLERYLHMLLADRCRLSTFYEDW 149
Query: 160 AIMLRDE-ATILTGMLIGLSAIDFSFCLKGEVLDGKT---PVVID--------YTPYLK- 206
+ ++ +E +++L M GL++I F+ + + L+G++ P V D T LK
Sbjct: 150 SFVMDEERSSMLPTMAAGLNSILFAINIDNKDLNGQSKFAPTVSDLLKESTQNVTSLLKE 209
Query: 207 FTQSYDYLTDEEERHSAESSTSEDNSPEHPYLPLVTDEDSWYSKWHKMEQK 257
TQ L E SA S + P LP+V+ S +K K +K
Sbjct: 210 STQGVSSLFREITASSAVSILIKPEQETDP-LPVVSRNVSADAKCKKERKK 259
>gi|221139728 pleckstrin homology domain containing, family M (with
RUN domain) member 2 [Homo sapiens]
Length = 1019
Score = 45.4 bits (106), Expect = 1e-04
Identities = 43/184 (23%), Positives = 74/184 (40%), Gaps = 20/184 (10%)
Query: 38 SVKTLLEKYTAEPIDDSSEEFVNFAAILEQILSHRFKACAPAGPVSWFSSDGQRGFWDYI 97
SVK L + A +D N +L+++ H A + + D G+W
Sbjct: 17 SVKKLQSYFAA--CEDEIPAIRNHDKVLQRLCEHLDHA------LLYGLQDLSSGYWV-- 66
Query: 98 RLACSKVPNNCVSSIENMENISTARAKGRAWIRVALMEKRMSEYITTALRDTRTTRRFYD 157
L + IE +++++T + RAW+ +AL E + Y+ + ++Y
Sbjct: 67 -LVVHFTRREAIKQIEVLQHVATNLGRSRAWLYLALNENSLESYLRLFQENLGLLHKYYV 125
Query: 158 SGAIML-RDEATILTGMLIGLSAIDFSFCLKGEVLDGKTPVVIDYTPYLKFTQSYDYLTD 216
A++ D T+ ++ GL I F LD P +D PY+ YL D
Sbjct: 126 KNALVCSHDHLTLFLTLVSGLEFIRFE-------LDLDAP-YLDLAPYMPDYYKPQYLLD 177
Query: 217 EEER 220
E+R
Sbjct: 178 FEDR 181
>gi|122891862 DENN/MADD domain containing 5B [Homo sapiens]
Length = 1274
Score = 42.7 bits (99), Expect = 7e-04
Identities = 24/75 (32%), Positives = 42/75 (56%), Gaps = 2/75 (2%)
Query: 112 IENMENISTARAKGRAWIRVALMEKRMSEYITTALRDTRTTRRFYDSGAIM-LRDEATIL 170
I+NM I T + RAWIR++L +K +S+++ L + T++ Y A + +E
Sbjct: 853 IQNMSEIKTDVGRARAWIRLSLEKKLLSQHLKQLLSNQPLTKKLYKRYAFLRCEEEREQF 912
Query: 171 TGMLIGLSAIDFSFC 185
L+ L+A+D+ FC
Sbjct: 913 LYHLLSLNAVDY-FC 926
>gi|44889475 RAB6 interacting protein 1 [Homo sapiens]
Length = 1287
Score = 41.2 bits (95), Expect = 0.002
Identities = 23/75 (30%), Positives = 40/75 (53%), Gaps = 2/75 (2%)
Query: 112 IENMENISTARAKGRAWIRVALMEKRMSEYITTALRDTRTTRRFYDSGAIM-LRDEATIL 170
I+N+ I T K RAW+R+++ +K +S ++ L D T++ Y A + DE
Sbjct: 871 IQNIGEIKTDVGKARAWVRLSMEKKLLSRHLKQLLSDHELTKKLYKRYAFLRCDDEKEQF 930
Query: 171 TGMLIGLSAIDFSFC 185
L+ +A+D+ FC
Sbjct: 931 LYHLLSFNAVDY-FC 944
>gi|38570149 WWC family member 3 [Homo sapiens]
Length = 1092
Score = 40.0 bits (92), Expect = 0.004
Identities = 56/225 (24%), Positives = 92/225 (40%), Gaps = 31/225 (13%)
Query: 243 DEDSWYSKWHKMEQKFRIVYAQKGYLEELV-----RLRESQLKDLEAENRRLQLQLEEAA 297
D +SW S + +++ ++ L+EL R + LE E RL+ +L A
Sbjct: 256 DNESWPSTAEADRDRLQLIKEKEALLQELQLIIAQRRSAGDVARLEEERERLEEELRRAR 315
Query: 298 AQNQREKRELEGVILELQEQLTGLIPSDHAPLAQGSKELTTPLVNQWPSL--GTLNGAEG 355
A + + E + LQE+ L+ + + LT+ L +Q SL TL + G
Sbjct: 316 ATSAQGATER----ILLQEKRNCLLMQ-----LEEATRLTSYLQSQLKSLCASTLTVSSG 366
Query: 356 ASNSKLYRRHSFMSTEPLSAEASLSSDSQRL-------GEGTR----DEEPWGPIGKDPT 404
+S L +++ S + +D L EG++ D P+ +G+D
Sbjct: 367 SSRGSLASSRGSLASSRGSLSSVSFTDIYGLPQYEKPDAEGSQLLRFDLIPFDSLGRDAP 426
Query: 405 ----PSMLGLCGSLASIPSCKSLASFKSNECLVSDSPEGSPALSP 445
P G S+ + +SLAS S L S SP SP +P
Sbjct: 427 FSEPPGPSGFHKQRRSLDTPQSLASLSSRSSLSSLSPPSSPLDTP 471
>gi|48762942 huntingtin interacting protein-1-related [Homo sapiens]
Length = 1068
Score = 38.5 bits (88), Expect = 0.012
Identities = 34/117 (29%), Positives = 52/117 (44%), Gaps = 9/117 (7%)
Query: 269 EELVRLRESQLKDLEAENRRLQLQLEEAAAQNQREKRELEGVILELQEQLTGLIPSDHAP 328
EE+ R++E +E R +L+LEE + Q ++ KRELE EL L ++
Sbjct: 483 EEVARVKEQLAFQVEQVKRESELKLEEKSDQLEKLKRELEAKAGELARAQEALSHTE--- 539
Query: 329 LAQGSKELTTPLVNQWPSLGTLNGAEGASNSKLYRRHSFMSTEPLSAEASLSSDSQR 385
Q EL++ L L+GA + L S + EA+LS + QR
Sbjct: 540 --QSKSELSSRLDTLSAEKDALSGAVRQREADLLAAQSLVR----ETEAALSREQQR 590
Score = 30.4 bits (67), Expect = 3.4
Identities = 18/69 (26%), Positives = 34/69 (49%)
Query: 253 KMEQKFRIVYAQKGYLEELVRLRESQLKDLEAENRRLQLQLEEAAAQNQREKRELEGVIL 312
++ + + A+K L VR RE+ L ++ R + L ++ +E+ EL+G +
Sbjct: 544 ELSSRLDTLSAEKDALSGAVRQREADLLAAQSLVRETEAALSREQQRSSQEQGELQGRLA 603
Query: 313 ELQEQLTGL 321
E + Q GL
Sbjct: 604 ERESQEQGL 612
>gi|239750456 PREDICTED: similar to KIAA0655 protein [Homo sapiens]
Length = 1048
Score = 38.5 bits (88), Expect = 0.012
Identities = 34/117 (29%), Positives = 52/117 (44%), Gaps = 9/117 (7%)
Query: 269 EELVRLRESQLKDLEAENRRLQLQLEEAAAQNQREKRELEGVILELQEQLTGLIPSDHAP 328
EE+ R++E +E R +L+LEE + Q ++ KRELE EL L ++
Sbjct: 463 EEVARVKEQLAFQVEQVKRESELKLEEKSDQLEKLKRELEAKAGELARAQEALSHTE--- 519
Query: 329 LAQGSKELTTPLVNQWPSLGTLNGAEGASNSKLYRRHSFMSTEPLSAEASLSSDSQR 385
Q EL++ L L+GA + L S + EA+LS + QR
Sbjct: 520 --QSKSELSSRLDTLSAEKDALSGAVRQREADLLAAQSLVR----ETEAALSREQQR 570
Score = 30.4 bits (67), Expect = 3.4
Identities = 18/69 (26%), Positives = 34/69 (49%)
Query: 253 KMEQKFRIVYAQKGYLEELVRLRESQLKDLEAENRRLQLQLEEAAAQNQREKRELEGVIL 312
++ + + A+K L VR RE+ L ++ R + L ++ +E+ EL+G +
Sbjct: 524 ELSSRLDTLSAEKDALSGAVRQREADLLAAQSLVRETEAALSREQQRSSQEQGELQGRLA 583
Query: 313 ELQEQLTGL 321
E + Q GL
Sbjct: 584 ERESQEQGL 592
>gi|41872583 Rho-associated, coiled-coil containing protein kinase 2
[Homo sapiens]
Length = 1388
Score = 38.1 bits (87), Expect = 0.016
Identities = 28/87 (32%), Positives = 43/87 (49%), Gaps = 2/87 (2%)
Query: 269 EELVR-LRESQLKDLEAENRRLQLQLEEAAAQNQREKRELEGVILELQEQLTGLIPSDHA 327
E+L R + E Q DLE E +L+++E A++++E E + I L E+ + SD A
Sbjct: 925 EQLARSIAEEQYSDLEKEKIMKELEIKEMMARHKQELTEKDATIASL-EETNRTLTSDVA 983
Query: 328 PLAQGSKELTTPLVNQWPSLGTLNGAE 354
LA +EL L + L L E
Sbjct: 984 NLANEKEELNNKLKDVQEQLSRLKDEE 1010
Score = 32.0 bits (71), Expect = 1.2
Identities = 14/47 (29%), Positives = 30/47 (63%)
Query: 272 VRLRESQLKDLEAENRRLQLQLEEAAAQNQREKRELEGVILELQEQL 318
+++ E QLK +++ LE+ A+ ++E+++ +G + ELQ+QL
Sbjct: 820 LKMSEKQLKQENNHLMEMKMNLEKQNAELRKERQDADGQMKELQDQL 866
>gi|210032790 hypothetical protein LOC27146 [Homo sapiens]
Length = 1060
Score = 36.6 bits (83), Expect = 0.047
Identities = 40/137 (29%), Positives = 61/137 (44%), Gaps = 24/137 (17%)
Query: 185 CLKGEVLDGKTPVVIDYTPYLKFTQSYDYLTDEEERHSAESSTSEDNSPEHPYLPLVTD- 243
CLK LD +P +Y L + +DEEER + E + P+ P L+ +
Sbjct: 535 CLK---LDETSPRGEEYQDKLAAEEGTS--SDEEER--TKVLLKEGSDPQPPLGSLLKEK 587
Query: 244 -------EDSWYSKWHKMEQKFR-----IVYAQKGYLEELVRLRESQLKDLEAENRRLQL 291
E+ W S+ K++ + + Y E+L L+ QL DLE E +LQ
Sbjct: 588 TSKIQRLEEDWQSQKAKLQAQVSQMQQALEQCTSNYREDLQALK--QLSDLERE--KLQR 643
Query: 292 QLEEAAAQNQREKRELE 308
+L+E QN K +LE
Sbjct: 644 ELQETTQQNHAMKAQLE 660
Score = 35.0 bits (79), Expect = 0.14
Identities = 50/208 (24%), Positives = 89/208 (42%), Gaps = 34/208 (16%)
Query: 224 ESSTSEDNSPEHPYLPLVTDEDSWYSKWHKMEQKFRIVYAQKGYLEELVRLRESQLKDL- 282
+ T ++ S E Y+ +ED K E+K + LE+LV+ ++K +
Sbjct: 388 DMQTKKEASAETEYMKQQYEEDLRKIKHQTEEEKKHLKDQLVKRLEDLVKKHTVEIKSVR 447
Query: 283 ---EAENRRLQ----LQLEEAAAQNQREKRELE----GVILELQEQLTGLIP-----SDH 326
EAE ++LQ QLEE ++++E ++LE + ++LQ L ++ +
Sbjct: 448 SSVEAERKKLQREVEAQLEEVRKKSEKEIKQLEEEKAALNVKLQNSLLEVLRLEEFIQQN 507
Query: 327 APLAQGSKELTTPLVNQWPSL-----GTLNGAEGASNSKLYRRHSFMSTEPLSAEASLSS 381
G++E L Q S+ L E + + Y+ + L+AE SS
Sbjct: 508 KTRPTGAEESPQELGRQHCSILETQDPCLKLDETSPRGEEYQ-------DKLAAEEGTSS 560
Query: 382 DSQR-----LGEGTRDEEPWGPIGKDPT 404
D + L EG+ + P G + K+ T
Sbjct: 561 DEEERTKVLLKEGSDPQPPLGSLLKEKT 588
>gi|112421127 tripartite motif-containing 58 [Homo sapiens]
Length = 486
Score = 36.6 bits (83), Expect = 0.047
Identities = 43/175 (24%), Positives = 75/175 (42%), Gaps = 18/175 (10%)
Query: 247 WYSKWHKMEQKFRIVYAQ-KGYLEELVRLRESQLKDLEAENRRLQLQLEEAAAQNQREKR 305
W K Q+FR+ + + +G+L + + QL+ LEAE R +L E+ ++ ++ +
Sbjct: 171 WKEKVEMQRQRFRLEFEKHRGFLAQE---EQRQLRRLEAEERATLQRLRESKSRLVQQSK 227
Query: 306 ELEGVILELQEQ----LTGLIPSDHAPLAQGSKELTTPLVNQWPSLGTLNGAEGASNSKL 361
L+ + ELQE+ GL+ L++ N L T G +L
Sbjct: 228 ALKELADELQERCQRPALGLLEGVRGVLSRSKAVTRLEAENIPMELKTACCIPG--RREL 285
Query: 362 YRRHSF-MSTEPLSAEASLSSDSQRLGEGTRDEEPWGPIGKDPT-----PSMLGL 410
R+ + +P +A SL + +D EPW + +P P +LGL
Sbjct: 286 LRKFQVDVKLDPATAHPSLLLTADL--RSVQDGEPWRDVPNNPERFDTWPCILGL 338
>gi|32698688 citron [Homo sapiens]
Length = 2027
Score = 36.2 bits (82), Expect = 0.062
Identities = 38/125 (30%), Positives = 59/125 (47%), Gaps = 12/125 (9%)
Query: 259 RIVYAQKGYLEELVRLR---ESQLKDLEAENRRLQLQLEEAAAQNQREKRELEGVILELQ 315
R + AQ+ + EL + + E+Q LEA+NR+L+ QLE+ + Q+ +K L LEL+
Sbjct: 800 RNMKAQEEMISELRQQKFYLETQAGKLEAQNRKLEEQLEKISHQDHSDKNRL----LELE 855
Query: 316 EQLTGLI---PSDHAPLAQGSKELTTPLVNQWPSLGTLNGAEGASNSKLYRRHSFMSTEP 372
+L + L + EL L + L L A A S+L R + E
Sbjct: 856 TRLREVSLEHEEQKLELKRQLTELQLSLQERESQLTALQAARAALESQL--RQAKTELEE 913
Query: 373 LSAEA 377
+AEA
Sbjct: 914 TTAEA 918
Score = 33.1 bits (74), Expect = 0.52
Identities = 25/111 (22%), Positives = 49/111 (44%)
Query: 207 FTQSYDYLTDEEERHSAESSTSEDNSPEHPYLPLVTDEDSWYSKWHKMEQKFRIVYAQKG 266
++++ L E S S ++ +S E L + K HKMEQ+ ++ +
Sbjct: 421 YSKALGILGRSESVVSGLDSPAKTSSMEKKLLIKSKELQDSQDKCHKMEQEMTRLHRRVS 480
Query: 267 YLEELVRLRESQLKDLEAENRRLQLQLEEAAAQNQREKRELEGVILELQEQ 317
+E ++ +E +LK E + L+ L + KR LE +E+ ++
Sbjct: 481 EVEAVLSQKEVELKASETQRSLLEQDLATYITECSSLKRSLEQARMEVSQE 531
Score = 29.6 bits (65), Expect = 5.8
Identities = 28/81 (34%), Positives = 41/81 (50%), Gaps = 15/81 (18%)
Query: 255 EQKFRIVYAQKGYLEELVRLRESQLK-----DLEAENRRLQLQ--LEEAAAQNQREKREL 307
+QKF + Q G LE R E QL+ D +NR L+L+ L E + +++ +K EL
Sbjct: 814 QQKFYLE-TQAGKLEAQNRKLEEQLEKISHQDHSDKNRLLELETRLREVSLEHEEQKLEL 872
Query: 308 EGVILELQ-------EQLTGL 321
+ + ELQ QLT L
Sbjct: 873 KRQLTELQLSLQERESQLTAL 893
>gi|115496169 myosin, heavy chain 7, cardiac muscle, beta [Homo
sapiens]
Length = 1935
Score = 35.8 bits (81), Expect = 0.081
Identities = 47/200 (23%), Positives = 80/200 (40%), Gaps = 9/200 (4%)
Query: 206 KFTQSYDYLTDEEERHSAESSTSEDNSPEHPYLPLVTDEDSWYSKWHKMEQKFRIVYAQK 265
K+ +S L E + A S ++E ++ Y + +++ + ++++ + Q
Sbjct: 1459 KYEESQSEL--ESSQKEARSLSTELFKLKNAYEESLEHLETFKRENKNLQEEISDLTEQL 1516
Query: 266 GYLEELVRLRESQLKDLEAENRRLQLQLEEAAAQNQREKRELEGVILELQEQLTGLIPSD 325
G + + E K LEAE LQ LEEA A + E EG IL Q + +
Sbjct: 1517 GSSGKTIHELEKVRKQLEAEKMELQSALEEAEASLEHE----EGKILRAQLEFNQIKAEI 1572
Query: 326 HAPLAQGSKELTTPLVNQW---PSLGTLNGAEGASNSKLYRRHSFMSTEPLSAEASLSSD 382
LA+ +E+ N SL T AE S ++ R M + E LS
Sbjct: 1573 ERKLAEKDEEMEQAKRNHLRVVDSLQTSLDAETRSRNEALRVKKKMEGDLNEMEIQLSHA 1632
Query: 383 SQRLGEGTRDEEPWGPIGKD 402
++ E + + + KD
Sbjct: 1633 NRMAAEAQKQVKSLQSLLKD 1652
>gi|156766068 CDC42 binding protein kinase gamma (DMPK-like) [Homo
sapiens]
Length = 1551
Score = 35.8 bits (81), Expect = 0.081
Identities = 39/142 (27%), Positives = 64/142 (45%), Gaps = 19/142 (13%)
Query: 265 KGYLEELV-RLRESQLKDLE--AENRRLQLQLEEAAAQNQREKRELEGVILELQEQLTGL 321
+G EEL+ RL+E+Q ++ ++ R L QLEEA A +RELE + L Q+T L
Sbjct: 516 QGQQEELLQRLQEAQEREAATASQTRALSSQLEEARAA----QRELEAQVSSLSRQVTQL 571
Query: 322 IPSDHAPLAQGSKELTTPLVNQWPSLGTLNGAE---------GASNSKLYRRHSFMSTEP 372
L + S+ T ++ +G G A +L + HS +
Sbjct: 572 QGQWEQRLEESSQAKTIHTASETNGMGPPEGGPQEAQLRKEVAALREQLEQAHSHRPSGK 631
Query: 373 LSAEASLSSDSQRLGEGTRDEE 394
A L +++RL +R++E
Sbjct: 632 EEALCQLQEENRRL---SREQE 650
>gi|21735548 centrosomal protein 2 [Homo sapiens]
Length = 2442
Score = 35.4 bits (80), Expect = 0.11
Identities = 26/88 (29%), Positives = 43/88 (48%), Gaps = 5/88 (5%)
Query: 239 PLVT--DEDSWYSKWHKMEQKFRIVYAQKGYLEELVRLRESQLKDLEAENRRLQLQLEE- 295
PL+T ++ S HK+ Q + L + V+ E +L D EAE ++ +L++
Sbjct: 1231 PLLTALSAEAVASALHKLHQDLWKTQQTRDVLRDQVQKLEERLTDTEAEKSQVHTELQDL 1290
Query: 296 --AAAQNQREKRELEGVILELQEQLTGL 321
+QNQ EK + EG L+ +L L
Sbjct: 1291 QRQLSQNQEEKSKWEGKQNSLESELMEL 1318
Score = 32.3 bits (72), Expect = 0.89
Identities = 21/72 (29%), Positives = 42/72 (58%), Gaps = 7/72 (9%)
Query: 253 KMEQKFRIVYAQKGYLEELVRLRESQLKDLEAENRRLQLQLEE-AAAQNQREKR------ 305
+++++ + V +Q+ +EEL R +E +DLE ++ L LQ E ++QR ++
Sbjct: 1624 ELQERDQEVKSQREQIEELQRQKEHLTQDLERRDQELMLQKERIQVLEDQRTRQTKILEE 1683
Query: 306 ELEGVILELQEQ 317
+LE + L L+E+
Sbjct: 1684 DLEQIKLSLRER 1695
Score = 31.6 bits (70), Expect = 1.5
Identities = 48/202 (23%), Positives = 80/202 (39%), Gaps = 29/202 (14%)
Query: 263 AQKGYLEELVRLRESQLKDLEAENRRLQLQLEEAAAQ------NQREKREL--------- 307
A LEE +R++E +++D + + QL++A AQ +Q+E+ +L
Sbjct: 2010 AHSRQLEEALRIQEGEIQDQDLRYQEDVQQLQQALAQRDEELRHQQEREQLLEKSLAQRV 2069
Query: 308 -EGVILELQEQLTGLIPSDHAPLAQGSKELTTPLVNQWPSLGTLNGAEGASNSKLY---R 363
E +I E Q + L Q +EL L + + L + +N +
Sbjct: 2070 QENMIQEKQNLGQEREEEEIRGLHQSVRELQLTLAQKEQEILELRETQQRNNLEALPHSH 2129
Query: 364 RHSFMSTEPL---SAEASLSSDSQRLGEGTRDEE----PWGPIGKDPTPSMLGLCGSLAS 416
+ S M + L S E L + +RL R E W +D L L + AS
Sbjct: 2130 KTSPMEEQSLKLDSLEPRLQRELERLQAALRQTEAREIEWREKAQD---LALSLAQTKAS 2186
Query: 417 IPSCKSLASFKSNECLVSDSPE 438
+ S + +A F L DS +
Sbjct: 2187 VSSLQEVAMFLQASVLERDSEQ 2208
Score = 29.6 bits (65), Expect = 5.8
Identities = 20/64 (31%), Positives = 31/64 (48%), Gaps = 1/64 (1%)
Query: 254 MEQKFRIVYAQKGYLEELVRLRESQLKDLEAENRRLQLQLEEAAAQNQREKRELEGVILE 313
+EQ + + G L++ ++L E RR+Q LEE + E RE E +L
Sbjct: 1847 LEQAHMTLKERHGELQDHKEQARRLEEELAVEGRRVQA-LEEVLGDLRAESREQEKALLA 1905
Query: 314 LQEQ 317
LQ+Q
Sbjct: 1906 LQQQ 1909
Score = 29.3 bits (64), Expect = 7.6
Identities = 28/129 (21%), Positives = 52/129 (40%), Gaps = 11/129 (8%)
Query: 206 KFTQSYDYLTDEEERHSAE-SSTSEDNSPEHPYLPLVT--------DEDSWYSKWHKMEQ 256
K Q+ D L D+ ++ + T + S H L + ++ W K + +E
Sbjct: 1254 KTQQTRDVLRDQVQKLEERLTDTEAEKSQVHTELQDLQRQLSQNQEEKSKWEGKQNSLES 1313
Query: 257 KFRIVYAQKGYLEELVRLRESQLKDLEAENRRLQLQLEEAAAQNQREKRELEGVILELQE 316
+ ++ L+ RLR ++L+ +EA+ R LQ + Q E + V Q
Sbjct: 1314 ELMELHETMASLQS--RLRRAELQRMEAQGERELLQAAKENLTAQVEHLQAAVVEARAQA 1371
Query: 317 QLTGLIPSD 325
G++ D
Sbjct: 1372 SAAGILEED 1380
>gi|24430183 outer dense fiber of sperm tails 2 isoform 2 [Homo
sapiens]
Length = 638
Score = 35.0 bits (79), Expect = 0.14
Identities = 28/106 (26%), Positives = 52/106 (49%), Gaps = 10/106 (9%)
Query: 218 EERHSAESSTSEDNSPEHPYLPLVTDEDSWYSKWHKMEQKFRIVYAQKGYLEELVRLRES 277
E++ + +E +S + L L+ D+D + ++ Q+ + AQ EL + ES
Sbjct: 269 EQQGALLKRLAEADSEKARLLLLLQDKDK---EVEELLQEIQCEKAQAKTASELSKSMES 325
Query: 278 -------QLKDLEAENRRLQLQLEEAAAQNQREKRELEGVILELQE 316
QL+ EAEN RL +Q++ + K E+E ++ +L+E
Sbjct: 326 MRGHLQAQLRSKEAENSRLCMQIKNLERSGNQHKAEVEAIMEQLKE 371
>gi|24430181 outer dense fiber of sperm tails 2 isoform 1 [Homo
sapiens]
Length = 805
Score = 35.0 bits (79), Expect = 0.14
Identities = 28/106 (26%), Positives = 52/106 (49%), Gaps = 10/106 (9%)
Query: 218 EERHSAESSTSEDNSPEHPYLPLVTDEDSWYSKWHKMEQKFRIVYAQKGYLEELVRLRES 277
E++ + +E +S + L L+ D+D + ++ Q+ + AQ EL + ES
Sbjct: 264 EQQGALLKRLAEADSEKARLLLLLQDKDK---EVEELLQEIQCEKAQAKTASELSKSMES 320
Query: 278 -------QLKDLEAENRRLQLQLEEAAAQNQREKRELEGVILELQE 316
QL+ EAEN RL +Q++ + K E+E ++ +L+E
Sbjct: 321 MRGHLQAQLRSKEAENSRLCMQIKNLERSGNQHKAEVEAIMEQLKE 366
Database: hs.faa
Posted date: Aug 4, 2009 4:42 PM
Number of letters in database: 18,247,518
Number of sequences in database: 37,866
Lambda K H
0.314 0.129 0.371
Gapped
Lambda K H
0.267 0.0410 0.140
Matrix: BLOSUM62
Gap Penalties: Existence: 11, Extension: 1
Number of Hits to DB: 16,451,292
Number of Sequences: 37866
Number of extensions: 748871
Number of successful extensions: 4115
Number of sequences better than 10.0: 30
Number of HSP's better than 10.0 without gapping: 81
Number of HSP's successfully gapped in prelim test: 167
Number of HSP's that attempted gapping in prelim test: 3353
Number of HSP's gapped (non-prelim): 898
length of query: 446
length of database: 18,247,518
effective HSP length: 105
effective length of query: 341
effective length of database: 14,271,588
effective search space: 4866611508
effective search space used: 4866611508
T: 11
A: 40
X1: 16 ( 7.2 bits)
X2: 38 (14.6 bits)
X3: 64 (24.7 bits)
S1: 42 (22.0 bits)
S2: 63 (28.9 bits)
Search results were obtained with NCBI BLAST and RefSeq entries.
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Guide to the Human Genome
Copyright © 2010 by Stewart Scherer. All rights reserved.