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Search of human proteins with 221136876
BLASTP 2.2.11 [Jun-05-2005]
Reference: Altschul, Stephen F., Thomas L. Madden, Alejandro A. Schaffer,
Jinghui Zhang, Zheng Zhang, Webb Miller, and David J. Lipman (1997),
"Gapped BLAST and PSI-BLAST: a new generation of protein database search
programs", Nucleic Acids Res. 25:3389-3402.
Query= gi|221136876 Ras association (RalGDS/AF-6) domain family
(N-terminal) member 7 isoform 3 [Homo sapiens]
(320 letters)
Database: hs.faa
37,866 sequences; 18,247,518 total letters
Searching..................................................done
Score E
Sequences producing significant alignments: (bits) Value
gi|221136876 Ras association (RalGDS/AF-6) domain family (N-term... 636 0.0
gi|4502483 Ras association (RalGDS/AF-6) domain family (N-termin... 629 e-180
gi|221136872 Ras association (RalGDS/AF-6) domain family (N-term... 627 e-180
gi|23503243 Ras association (RalGDS/AF-6) domain family (N-termi... 182 3e-46
gi|22208850 Golgi coiled-coil protein 1 [Homo sapiens] 47 2e-05
gi|4504063 golgin 97 [Homo sapiens] 47 3e-05
gi|21735548 centrosomal protein 2 [Homo sapiens] 44 2e-04
gi|195972857 Rho/Rac guanine nucleotide exchange factor 18 isofo... 43 4e-04
gi|41327769 Rho/Rac guanine nucleotide exchange factor 18 isofor... 43 4e-04
gi|41322923 plectin 1 isoform 11 [Homo sapiens] 43 4e-04
gi|41322914 plectin 1 isoform 10 [Homo sapiens] 43 4e-04
gi|41322919 plectin 1 isoform 8 [Homo sapiens] 43 4e-04
gi|41322910 plectin 1 isoform 7 [Homo sapiens] 43 4e-04
gi|41322916 plectin 1 isoform 6 [Homo sapiens] 43 4e-04
gi|41322908 plectin 1 isoform 3 [Homo sapiens] 43 4e-04
gi|41322912 plectin 1 isoform 2 [Homo sapiens] 43 4e-04
gi|47607492 plectin 1 isoform 1 [Homo sapiens] 43 4e-04
gi|88196790 coiled-coil domain containing 88 [Homo sapiens] 42 6e-04
gi|153791497 ciliary rootlet coiled-coil [Homo sapiens] 41 0.001
gi|13124879 smooth muscle myosin heavy chain 11 isoform SM1A [Ho... 41 0.001
gi|92091586 smooth muscle myosin heavy chain 11 isoform SM1B [Ho... 41 0.001
gi|92091583 smooth muscle myosin heavy chain 11 isoform SM2B [Ho... 41 0.001
gi|13124875 smooth muscle myosin heavy chain 11 isoform SM2A [Ho... 41 0.001
gi|112382239 desmuslin isoform B [Homo sapiens] 41 0.001
gi|112382237 desmuslin isoform A [Homo sapiens] 41 0.001
gi|10864047 epidermal growth factor receptor pathway substrate 1... 41 0.001
gi|78042577 MAP7 domain containing 1 [Homo sapiens] 41 0.001
gi|41406064 myosin, heavy polypeptide 10, non-muscle [Homo sapiens] 41 0.002
gi|114842389 myosin, heavy polypeptide 7B, cardiac muscle, beta ... 40 0.002
gi|14249342 internexin neuronal intermediate filament protein, a... 40 0.003
>gi|221136876 Ras association (RalGDS/AF-6) domain family
(N-terminal) member 7 isoform 3 [Homo sapiens]
Length = 320
Score = 636 bits (1641), Expect = 0.0
Identities = 320/320 (100%), Positives = 320/320 (100%)
Query: 1 MLLGLAAMELKVWVDGIQRVVCGVSEQTTCQEVVIALAQAIGQTGRFVLVQRLREKERQL 60
MLLGLAAMELKVWVDGIQRVVCGVSEQTTCQEVVIALAQAIGQTGRFVLVQRLREKERQL
Sbjct: 1 MLLGLAAMELKVWVDGIQRVVCGVSEQTTCQEVVIALAQAIGQTGRFVLVQRLREKERQL 60
Query: 61 LPQECPVGAQATCGQFASDVQFVLRRTGPSLAGRPSSDSCPPPERCLIRASLPVKPRAAL 120
LPQECPVGAQATCGQFASDVQFVLRRTGPSLAGRPSSDSCPPPERCLIRASLPVKPRAAL
Sbjct: 61 LPQECPVGAQATCGQFASDVQFVLRRTGPSLAGRPSSDSCPPPERCLIRASLPVKPRAAL 120
Query: 121 GCEPRKTLTPEPAPSLSRPGPAAPVTPTPGCCTDLRGLELRVQRNAEELGHEAFWEQELR 180
GCEPRKTLTPEPAPSLSRPGPAAPVTPTPGCCTDLRGLELRVQRNAEELGHEAFWEQELR
Sbjct: 121 GCEPRKTLTPEPAPSLSRPGPAAPVTPTPGCCTDLRGLELRVQRNAEELGHEAFWEQELR 180
Query: 181 REQAREREGQARLQALSAATAEHAARLQALDAQARALEAELQLAAEAPGPPSPMASATER 240
REQAREREGQARLQALSAATAEHAARLQALDAQARALEAELQLAAEAPGPPSPMASATER
Sbjct: 181 REQAREREGQARLQALSAATAEHAARLQALDAQARALEAELQLAAEAPGPPSPMASATER 240
Query: 241 LHQDLAVQERQSAEVQGSLALVSRALEAAERALQAQAQELEELNRELRQCNLQQFIQQTG 300
LHQDLAVQERQSAEVQGSLALVSRALEAAERALQAQAQELEELNRELRQCNLQQFIQQTG
Sbjct: 241 LHQDLAVQERQSAEVQGSLALVSRALEAAERALQAQAQELEELNRELRQCNLQQFIQQTG 300
Query: 301 AALPPPPRPDRGPPGTQWPP 320
AALPPPPRPDRGPPGTQWPP
Sbjct: 301 AALPPPPRPDRGPPGTQWPP 320
>gi|4502483 Ras association (RalGDS/AF-6) domain family (N-terminal)
member 7 isoform 1 [Homo sapiens]
Length = 373
Score = 629 bits (1621), Expect = e-180
Identities = 318/319 (99%), Positives = 318/319 (99%)
Query: 1 MLLGLAAMELKVWVDGIQRVVCGVSEQTTCQEVVIALAQAIGQTGRFVLVQRLREKERQL 60
MLLGLAAMELKVWVDGIQRVVCGVSEQTTCQEVVIALAQAIGQTGRFVLVQRLREKERQL
Sbjct: 1 MLLGLAAMELKVWVDGIQRVVCGVSEQTTCQEVVIALAQAIGQTGRFVLVQRLREKERQL 60
Query: 61 LPQECPVGAQATCGQFASDVQFVLRRTGPSLAGRPSSDSCPPPERCLIRASLPVKPRAAL 120
LPQECPVGAQATCGQFASDVQFVLRRTGPSLAGRPSSDSCPPPERCLIRASLPVKPRAAL
Sbjct: 61 LPQECPVGAQATCGQFASDVQFVLRRTGPSLAGRPSSDSCPPPERCLIRASLPVKPRAAL 120
Query: 121 GCEPRKTLTPEPAPSLSRPGPAAPVTPTPGCCTDLRGLELRVQRNAEELGHEAFWEQELR 180
GCEPRKTLTPEPAPSLSRPGPAAPVTPTPGCCTDLRGLELRVQRNAEELGHEAFWEQELR
Sbjct: 121 GCEPRKTLTPEPAPSLSRPGPAAPVTPTPGCCTDLRGLELRVQRNAEELGHEAFWEQELR 180
Query: 181 REQAREREGQARLQALSAATAEHAARLQALDAQARALEAELQLAAEAPGPPSPMASATER 240
REQAREREGQARLQALSAATAEHAARLQALDAQARALEAELQLAAEAPGPPSPMASATER
Sbjct: 181 REQAREREGQARLQALSAATAEHAARLQALDAQARALEAELQLAAEAPGPPSPMASATER 240
Query: 241 LHQDLAVQERQSAEVQGSLALVSRALEAAERALQAQAQELEELNRELRQCNLQQFIQQTG 300
LHQDLAVQERQSAEVQGSLALVSRALEAAERALQAQAQELEELNRELRQCNLQQFIQQTG
Sbjct: 241 LHQDLAVQERQSAEVQGSLALVSRALEAAERALQAQAQELEELNRELRQCNLQQFIQQTG 300
Query: 301 AALPPPPRPDRGPPGTQWP 319
AALPPPPRPDRGPPGTQ P
Sbjct: 301 AALPPPPRPDRGPPGTQGP 319
>gi|221136872 Ras association (RalGDS/AF-6) domain family
(N-terminal) member 7 isoform 2 [Homo sapiens]
Length = 337
Score = 627 bits (1616), Expect = e-180
Identities = 317/317 (100%), Positives = 317/317 (100%)
Query: 1 MLLGLAAMELKVWVDGIQRVVCGVSEQTTCQEVVIALAQAIGQTGRFVLVQRLREKERQL 60
MLLGLAAMELKVWVDGIQRVVCGVSEQTTCQEVVIALAQAIGQTGRFVLVQRLREKERQL
Sbjct: 1 MLLGLAAMELKVWVDGIQRVVCGVSEQTTCQEVVIALAQAIGQTGRFVLVQRLREKERQL 60
Query: 61 LPQECPVGAQATCGQFASDVQFVLRRTGPSLAGRPSSDSCPPPERCLIRASLPVKPRAAL 120
LPQECPVGAQATCGQFASDVQFVLRRTGPSLAGRPSSDSCPPPERCLIRASLPVKPRAAL
Sbjct: 61 LPQECPVGAQATCGQFASDVQFVLRRTGPSLAGRPSSDSCPPPERCLIRASLPVKPRAAL 120
Query: 121 GCEPRKTLTPEPAPSLSRPGPAAPVTPTPGCCTDLRGLELRVQRNAEELGHEAFWEQELR 180
GCEPRKTLTPEPAPSLSRPGPAAPVTPTPGCCTDLRGLELRVQRNAEELGHEAFWEQELR
Sbjct: 121 GCEPRKTLTPEPAPSLSRPGPAAPVTPTPGCCTDLRGLELRVQRNAEELGHEAFWEQELR 180
Query: 181 REQAREREGQARLQALSAATAEHAARLQALDAQARALEAELQLAAEAPGPPSPMASATER 240
REQAREREGQARLQALSAATAEHAARLQALDAQARALEAELQLAAEAPGPPSPMASATER
Sbjct: 181 REQAREREGQARLQALSAATAEHAARLQALDAQARALEAELQLAAEAPGPPSPMASATER 240
Query: 241 LHQDLAVQERQSAEVQGSLALVSRALEAAERALQAQAQELEELNRELRQCNLQQFIQQTG 300
LHQDLAVQERQSAEVQGSLALVSRALEAAERALQAQAQELEELNRELRQCNLQQFIQQTG
Sbjct: 241 LHQDLAVQERQSAEVQGSLALVSRALEAAERALQAQAQELEELNRELRQCNLQQFIQQTG 300
Query: 301 AALPPPPRPDRGPPGTQ 317
AALPPPPRPDRGPPGTQ
Sbjct: 301 AALPPPPRPDRGPPGTQ 317
>gi|23503243 Ras association (RalGDS/AF-6) domain family
(N-terminal) member 8 [Homo sapiens]
Length = 392
Score = 182 bits (462), Expect = 3e-46
Identities = 138/372 (37%), Positives = 190/372 (51%), Gaps = 77/372 (20%)
Query: 8 MELKVWVDGIQRVVCGVSEQTTCQEVVIALAQAIGQTGRFVLVQRLREKERQLLPQECPV 67
MELKVWVDG+QR+VCGV+E TTCQEVVIALAQAIG+TGR+ L+++ R+ ER L P E P+
Sbjct: 1 MELKVWVDGVQRIVCGVTEVTTCQEVVIALAQAIGRTGRYTLIEKWRDTERHLAPHENPI 60
Query: 68 GAQATCGQFASDVQFVLRRTGPSLAGRPSSDSCPP-PERCLIRASLPVKPRAALGCEPRK 126
+ GQ+ASDVQ +LRRTGPSL+ RP+SDS PER L R SLP P A L + K
Sbjct: 61 ISLNKWGQYASDVQLILRRTGPSLSERPTSDSVARIPERTLYRQSLP--PLAKLRPQIDK 118
Query: 127 TL-TPEP-APSLSRPGPAAPVTPTPG--------------CCT--------------DLR 156
++ EP SL+ G A + G C T L+
Sbjct: 119 SIKRREPKRKSLTFTGGAKGLMDIFGKGKETEFKQKVLNNCKTTADELKKLIRLQTEKLQ 178
Query: 157 GLELRVQRNAEELGHEAFWEQ--------------------------------ELRREQA 184
+E +++ N E+ FWEQ EL+ EQ
Sbjct: 179 SIEKQLESNEIEI---RFWEQKYNSNLEEEIVRLEQKIKRNDVEIEEEEFWENELQIEQE 235
Query: 185 REREGQARLQALSAATAEHAARLQALDAQARALEAELQL------AAEAPGPPSPMASAT 238
E++ + +LQ + E +L+ AQ R +E+ L+ EA +
Sbjct: 236 NEKQLKDQLQEIRQKITECENKLKDYLAQIRTMESGLEAEKLQREVQEAQVNEEEVKGKI 295
Query: 239 ERLHQDLAVQERQSAEVQGSLALVSRALEAAERALQAQAQELEELNRELRQCNLQQFIQQ 298
++ ++ +Q +QS ++ + V R+L A + LQ + QELE+L +ELRQ NLQQFIQQ
Sbjct: 296 GKVKGEIDIQGQQSLRLENGIKAVERSLGQATKRLQDKEQELEQLTKELRQVNLQQFIQQ 355
Query: 299 TG---AALPPPP 307
TG LP P
Sbjct: 356 TGTKVTVLPAEP 367
>gi|22208850 Golgi coiled-coil protein 1 [Homo sapiens]
Length = 775
Score = 47.0 bits (110), Expect = 2e-05
Identities = 38/148 (25%), Positives = 71/148 (47%), Gaps = 9/148 (6%)
Query: 153 TDLRGLELRVQRNAEELGHEAFWEQELR------REQARE-REGQARLQALSAATAEHAA 205
T + LELR++ E L A+ +++ ++ RE E ++ LQA+ +
Sbjct: 259 TQRQDLELRLEETREALAGRAYAAEQMEGFELQTKQLTREVEELKSELQAIRDEKNQPDP 318
Query: 206 RLQALDAQARALEAELQLAAEAPGPPSPMASATERLHQDLAVQERQSAEVQGSLALVSRA 265
RLQ L +A L++ Q A+ A A ++L Q V+E++ A ++ ++ VS
Sbjct: 319 RLQELQEEAARLKSHFQ--AQLQQEMRKTALAEDQLRQQSQVEEQRVAALENQISEVSEL 376
Query: 266 LEAAERALQAQAQELEELNRELRQCNLQ 293
L E+A Q +++L + Q +L+
Sbjct: 377 LGTYEKAKQKDQLAIQKLKERILQLDLE 404
>gi|4504063 golgin 97 [Homo sapiens]
Length = 767
Score = 46.6 bits (109), Expect = 3e-05
Identities = 43/142 (30%), Positives = 70/142 (49%), Gaps = 6/142 (4%)
Query: 158 LELRVQRNAEELGHEAFWEQELRREQAREREGQARLQALSAATAEHAARLQALDAQARAL 217
LE R+++N L E ++ L+ + E+ + Q L AA + A + L+ + R L
Sbjct: 303 LEKRLEQN---LSGEEHVQELLKEKTLAEQNLEDTRQQLLAARSSQAKAINTLETRVREL 359
Query: 218 EAELQLAAEAPGPPSPMASATERLHQDLAVQERQSAEVQG-SLALVSRALEAAERALQAQ 276
E LQ + E + +A E Q+LA ++S+ VQ +LAL + LE + AL+AQ
Sbjct: 360 EQTLQASEEQLQQSKGIVAAQETQIQELAAANQESSHVQQQALALEQQFLERTQ-ALEAQ 418
Query: 277 AQELEELNRELRQCNLQQFIQQ 298
LE R Q +Q ++Q
Sbjct: 419 IVALER-TRAADQTTAEQGMRQ 439
Score = 28.9 bits (63), Expect = 6.4
Identities = 29/130 (22%), Positives = 52/130 (40%), Gaps = 11/130 (8%)
Query: 158 LELRVQRNAEELGHEAFWEQELRREQAREREGQARLQALSAATAEHAARLQALDAQARAL 217
LE+ ++++ ++ F EQ + R + + AL+ E + ++ L+ + L
Sbjct: 91 LEIALEKH-QDSSMRKFQEQNETFQANRAKMAEGLALALARKDQEWSEKMDQLEKEKNIL 149
Query: 218 EAELQLAAEAPGPPSPMASATERLHQDLAVQERQSAEVQGSLALVSRALEAAERALQAQA 277
A+LQ M + + L Q + Q L+ + L E +L
Sbjct: 150 TAQLQ----------EMKNQSMNLFQRRDEMDELEGFQQQELSKIKHMLLKKEESLGKME 199
Query: 278 QELEELNREL 287
QELE REL
Sbjct: 200 QELEARTREL 209
>gi|21735548 centrosomal protein 2 [Homo sapiens]
Length = 2442
Score = 43.5 bits (101), Expect = 2e-04
Identities = 46/153 (30%), Positives = 69/153 (45%), Gaps = 25/153 (16%)
Query: 161 RVQRNAEELGHEAFWEQELRREQAREREGQARLQALSA---------------ATAEHAA 205
+++ + E G E +++L +E+A E +G ++ Q S EH
Sbjct: 1687 QIKLSLRERGRELTTQRQLMQERAEEGKGPSKAQRGSLEHMKLILRDKEKEVECQQEHIH 1746
Query: 206 RLQALDAQARALEAELQLAAEAPGPPSPMASATERLHQDLAV--QERQSAEVQGSLALVS 263
LQ L Q LE +LQ G S + S E Q++ V Q+ Q A QG L S
Sbjct: 1747 ELQELKDQ---LEQQLQGLHRKVGETSLLLSQRE---QEIVVLQQQLQEAREQGELKEQS 1800
Query: 264 --RALEAAERALQAQAQELEELNRELRQCNLQQ 294
L+ A+RAL + QELE L +E +Q Q+
Sbjct: 1801 LQSQLDEAQRALAQRDQELEALQQEQQQAQGQE 1833
Score = 38.9 bits (89), Expect = 0.006
Identities = 43/142 (30%), Positives = 58/142 (40%), Gaps = 7/142 (4%)
Query: 159 ELRVQRNAEELGHEAFWEQELRREQAREREGQARLQALSAATAEHAARLQALDAQARALE 218
E R Q +E ++ ++ R R++E +A Q A + + DA ALE
Sbjct: 1789 EAREQGELKEQSLQSQLDEAQRALAQRDQELEALQQEQQQAQGQEERVKEKADALQGALE 1848
Query: 219 AELQLAAEAPGPPSPMASATERLHQDLAVQERQ---SAEVQGSLALVSRALEAAERALQ- 274
E G RL ++LAV+ R+ EV G L SR E A ALQ
Sbjct: 1849 QAHMTLKERHGELQDHKEQARRLEEELAVEGRRVQALEEVLGDLRAESREQEKALLALQQ 1908
Query: 275 ---AQAQELEELNRELRQCNLQ 293
QAQE E R L+ LQ
Sbjct: 1909 QCAEQAQEHEVETRALQDSWLQ 1930
Score = 37.0 bits (84), Expect = 0.023
Identities = 43/148 (29%), Positives = 66/148 (44%), Gaps = 20/148 (13%)
Query: 160 LRVQRNAEELGHEAFWEQELRREQAREREGQARLQALSAATAEHAARLQALDAQARALEA 219
L+V E EA WE+ E A+LQ A AE A L+ + + ++
Sbjct: 643 LQVDLAEAEKRREALWEKNTHLE--------AQLQKAEEAGAELQADLRDIQEEKEEIQK 694
Query: 220 ELQLAAEAPGPPSPMASATERLHQDLAVQERQSAE-VQGSLALVSR------ALEAAERA 272
+L +E+ + E+LHQ+ QE A VQ ALV L+A ER
Sbjct: 695 KL---SESRHQQEAATTQLEQLHQEAKRQEEVLARAVQEKEALVREKAALEVRLQAVERD 751
Query: 273 LQAQAQELEELN--RELRQCNLQQFIQQ 298
Q A++L+ L+ +EL + +L + QQ
Sbjct: 752 RQDLAEQLQGLSSAKELLESSLFEAQQQ 779
Score = 35.8 bits (81), Expect = 0.052
Identities = 47/176 (26%), Positives = 76/176 (43%), Gaps = 36/176 (20%)
Query: 153 TDLRGLELRVQRNAEELG----------------HE--AFWEQELRREQAREREGQARLQ 194
T+L+ L+ ++ +N EE HE A + LRR + + E Q +
Sbjct: 1285 TELQDLQRQLSQNQEEKSKWEGKQNSLESELMELHETMASLQSRLRRAELQRMEAQGERE 1344
Query: 195 ALSAATAEHAARLQALDA---QARA-------LEAELQLAAEAPGPPSPMASATERLHQD 244
L AA A+++ L A +ARA LE +L+ A A + + Q
Sbjct: 1345 LLQAAKENLTAQVEHLQAAVVEARAQASAAGILEEDLRTARSALKLKNEEVESERERAQA 1404
Query: 245 LAVQER----QSAEVQGSLALVSRALEAAE---RALQAQAQELEELNRELRQCNLQ 293
L Q Q +Q +LAL+++ L E L+ Q QELE+ RE+++ L+
Sbjct: 1405 LQEQGELKVAQGKALQENLALLTQTLAEREEEVETLRGQIQELEK-QREMQKAALE 1459
Score = 34.3 bits (77), Expect = 0.15
Identities = 38/135 (28%), Positives = 60/135 (44%), Gaps = 12/135 (8%)
Query: 159 ELRVQRNAEELGHEAFWEQELRREQAREREGQARLQALSAATAEHAARLQALDAQARALE 218
+LR + +E A +Q EQA+E E + R AL + + A L+ D + AL
Sbjct: 1891 DLRAESREQEKALLALQQQ--CAEQAQEHEVETR--ALQDSWLQAQAVLKERDQELEALR 1946
Query: 219 AELQLAAEAPGPPSPMASATE----RLHQDLAVQERQSAEVQGSLALVSRALEAAERALQ 274
AE Q + A A + + H L +E+ E A +SR+LEA+ LQ
Sbjct: 1947 AESQSSRHQEEAARARAEALQEALGKAHAALQGKEQHLLEQ----AELSRSLEASTATLQ 2002
Query: 275 AQAQELEELNRELRQ 289
A + +R+L +
Sbjct: 2003 ASLDACQAHSRQLEE 2017
Score = 32.7 bits (73), Expect = 0.44
Identities = 27/110 (24%), Positives = 51/110 (46%), Gaps = 10/110 (9%)
Query: 176 EQELRREQAREREGQARLQALSAATAEHAARLQALDAQARALEAE------LQLAAEAPG 229
E+E + R +E Q ++A+ A E + ++ Q + LE E L+ +
Sbjct: 881 EREKMELEMRLKEQQTEMEAIQAQREEERTQAESALCQMQ-LETEKERVSLLETLLQTQK 939
Query: 230 PPSPMASATERLHQDLAVQERQSAEVQGSLALVSRALEAAERALQAQAQE 279
+ + ERL QD+ VQ+ + E G ++ L+ A+R L+ A++
Sbjct: 940 ELADASQQLERLRQDMKVQKLKEQETTG---ILQTQLQEAQRELKEAARQ 986
Score = 32.3 bits (72), Expect = 0.58
Identities = 30/139 (21%), Positives = 58/139 (41%), Gaps = 10/139 (7%)
Query: 155 LRGLELRVQRNAEELGHEAFWEQELRREQAREREGQARLQALSAATAEHAARLQALDAQA 214
+R LE + L H+ E E + + + GQ + T E A L+
Sbjct: 1510 IRELEKDRETQRNVLEHQLL-ELEKKDQMIESQRGQVQDLKKQLVTLECLAL--ELEENH 1566
Query: 215 RALEAELQLAAEAPGPPSPMASATERL-------HQDLAVQERQSAEVQGSLALVSRALE 267
+E + +L E G A L Q+L Q Q +++ +++R L+
Sbjct: 1567 HKMECQQKLIKELEGQRETQRVALTHLTLDLEERSQELQAQSSQIHDLESHSTVLARELQ 1626
Query: 268 AAERALQAQAQELEELNRE 286
++ +++Q +++EEL R+
Sbjct: 1627 ERDQEVKSQREQIEELQRQ 1645
Score = 31.2 bits (69), Expect = 1.3
Identities = 29/127 (22%), Positives = 55/127 (43%), Gaps = 22/127 (17%)
Query: 159 ELRVQRNAEELGHEAFWEQELRREQAREREGQARLQALSAATAEHAARLQALDAQARALE 218
+LR R+A +L +E E E R QA + +G+ ++ AQ +AL+
Sbjct: 1380 DLRTARSALKLKNEEV-ESERERAQALQEQGELKV------------------AQGKALQ 1420
Query: 219 AELQLAAEAPGPPSPMASATERLHQDLAVQERQSAEVQGSLALVSRALEAAERALQAQAQ 278
L L + + E L + E+Q + +L L+S L+ + + Q +
Sbjct: 1421 ENLALLTQTL---AEREEEVETLRGQIQELEKQREMQKAALELLSLDLKKRNQEVDLQQE 1477
Query: 279 ELEELNR 285
+++EL +
Sbjct: 1478 QIQELEK 1484
Score = 30.4 bits (67), Expect = 2.2
Identities = 30/104 (28%), Positives = 42/104 (40%), Gaps = 10/104 (9%)
Query: 176 EQELRREQAREREGQARLQALSAATAEHAARLQALDAQARALEAELQLAAEAPGPPSPMA 235
E+E + +R + AL AE R +AL + LEA+LQ A EA
Sbjct: 623 EEENQSVCSRMEAAEQARNALQVDLAEAEKRREALWEKNTHLEAQLQKAEEAGA------ 676
Query: 236 SATERLHQDLAVQERQSAEVQGSLALVSRALEAAERALQAQAQE 279
L DL + + E+Q L+ EAA L+ QE
Sbjct: 677 ----ELQADLRDIQEEKEEIQKKLSESRHQQEAATTQLEQLHQE 716
Score = 29.6 bits (65), Expect = 3.7
Identities = 36/162 (22%), Positives = 62/162 (38%), Gaps = 31/162 (19%)
Query: 153 TDLRGLELRVQRNAEELGHEAFWEQELRREQAREREGQARLQALSAATA----------- 201
T++ R +++ EL E L+ E A R +L AL+ A A
Sbjct: 564 TEVTAALARAEQSIAELSSS---ENTLKTEVADLRAAAVKLSALNEALALDKVGLNQQLL 620
Query: 202 -------EHAARLQALDAQARALEAELQLAAEAPGPPSPMASATERLHQDLAVQERQSAE 254
+R++A + AL+ +L AEA + L L E AE
Sbjct: 621 QLEEENQSVCSRMEAAEQARNALQVDL---AEAEKRREALWEKNTHLEAQLQKAEEAGAE 677
Query: 255 VQGSLALVSRALEAAERAL-------QAQAQELEELNRELRQ 289
+Q L + E ++ L +A +LE+L++E ++
Sbjct: 678 LQADLRDIQEEKEEIQKKLSESRHQQEAATTQLEQLHQEAKR 719
>gi|195972857 Rho/Rac guanine nucleotide exchange factor 18 isoform
b [Homo sapiens]
Length = 1173
Score = 42.7 bits (99), Expect = 4e-04
Identities = 51/162 (31%), Positives = 65/162 (40%), Gaps = 40/162 (24%)
Query: 158 LELRVQRNAEELGHEAF----WEQELRREQAR-EREGQARLQALSAATAEHAARLQALDA 212
LE QRN E+ E + +LR EQ R ERE Q + Q L A ARLQ +
Sbjct: 850 LEQERQRNFEKQREERAALEKLQSQLRHEQQRWERERQWQHQELERA----GARLQEREG 905
Query: 213 QARALEAELQLAAEAPGPPSPMASATERLHQDLAVQERQSAEVQGSLALVSRALEAAERA 272
+AR L ERL Q+ A ERQ Q L L A+RA
Sbjct: 906 EARQLR--------------------ERLEQERAELERQRQAYQHDL----ERLREAQRA 941
Query: 273 LQAQAQELEELNRELRQCNLQQFIQQTGAALPPPPRPDRGPP 314
++ + + LE L R +Q ALPP + PP
Sbjct: 942 VERERERLELLRRLKKQ-------NTAPGALPPDTLAEAQPP 976
>gi|41327769 Rho/Rac guanine nucleotide exchange factor 18 isoform a
[Homo sapiens]
Length = 1015
Score = 42.7 bits (99), Expect = 4e-04
Identities = 51/162 (31%), Positives = 65/162 (40%), Gaps = 40/162 (24%)
Query: 158 LELRVQRNAEELGHEAF----WEQELRREQAR-EREGQARLQALSAATAEHAARLQALDA 212
LE QRN E+ E + +LR EQ R ERE Q + Q L A ARLQ +
Sbjct: 692 LEQERQRNFEKQREERAALEKLQSQLRHEQQRWERERQWQHQELERA----GARLQEREG 747
Query: 213 QARALEAELQLAAEAPGPPSPMASATERLHQDLAVQERQSAEVQGSLALVSRALEAAERA 272
+AR L ERL Q+ A ERQ Q L L A+RA
Sbjct: 748 EARQLR--------------------ERLEQERAELERQRQAYQHDL----ERLREAQRA 783
Query: 273 LQAQAQELEELNRELRQCNLQQFIQQTGAALPPPPRPDRGPP 314
++ + + LE L R +Q ALPP + PP
Sbjct: 784 VERERERLELLRRLKKQ-------NTAPGALPPDTLAEAQPP 818
>gi|41322923 plectin 1 isoform 11 [Homo sapiens]
Length = 4547
Score = 42.7 bits (99), Expect = 4e-04
Identities = 78/296 (26%), Positives = 121/296 (40%), Gaps = 37/296 (12%)
Query: 31 QEVVIALAQAIGQTGRFVLVQRLREKERQLLPQECPVGAQATCGQFASDVQF-----VLR 85
+E +A Q + R V+ EK+RQL AQA + A ++Q V+R
Sbjct: 1346 EEERLAEQQRAEERERLAEVEAALEKQRQLAEAHAQAKAQAE--REAKELQQRMQEEVVR 1403
Query: 86 RTGPSLAGRPSSDSCPPPERCLIRAS---LPVKPRAALGCEPRKTLTPEPAPSLSRPGPA 142
R ++ + S + L ++S + K R A E R L E + R
Sbjct: 1404 REEAAVDAQQQKRSIQEELQQLRQSSEAEIQAKARQAEAAE-RSRLRIEEEIRVVRLQLE 1462
Query: 143 APVTPTPGCCTDLRGLELRVQRNAEELGHEAFWEQELRREQARE---REGQARLQALSAA 199
A G +L+ L R + AE +A E E R Q ++ R+ QA ++ S
Sbjct: 1463 ATERQRGGAEGELQALRARAEE-AEAQKRQAQEEAERLRRQVQDESQRKRQAEVELASRV 1521
Query: 200 TAEHAA--------------RLQALDAQARALEAELQLAAEAP-GPPSPMASATERLHQD 244
AE A RLQA +A+ R +AE++ A + + SA L
Sbjct: 1522 KAEAEAAREKQRALQALEELRLQAEEAERRLRQAEVERARQVQVALETAQRSAEAELQSK 1581
Query: 245 LAVQERQSAEVQGSL----ALVSRALEAAERALQAQAQ---ELEELNRELRQCNLQ 293
A ++A+++ SL V++ E AER Q QA+ EE REL + L+
Sbjct: 1582 RASFAEKTAQLERSLQEEHVAVAQLREEAERRAQQQAEAERAREEAERELERWQLK 1637
Score = 40.4 bits (93), Expect = 0.002
Identities = 40/137 (29%), Positives = 57/137 (41%), Gaps = 9/137 (6%)
Query: 159 ELRVQRNAEELGHEAFWEQELRREQAREREGQARLQALSAATAEHAARLQALDAQARALE 218
E RVQ E E+ R +Q+ E + QAR QA +AA R +A AR +
Sbjct: 2095 EARVQAEREAAQSRRQVEEAERLKQSAEEQAQARAQAQAAA---EKLRKEAEQEAARRAQ 2151
Query: 219 AELQLAAEAPGPPSPMASATERLHQDLAVQE-RQSAEVQGSLALVSRALEAAERALQAQA 277
AE +A A A H+ A Q RQ A+V+ L + LE +
Sbjct: 2152 AE-----QAALRQKQAADAEMEKHKKFAEQTLRQKAQVEQELTTLRLQLEETDHQKNLLD 2206
Query: 278 QELEELNRELRQCNLQQ 294
+EL+ L E + Q+
Sbjct: 2207 EELQRLKAEATEAARQR 2223
Score = 35.8 bits (81), Expect = 0.052
Identities = 34/127 (26%), Positives = 56/127 (44%), Gaps = 4/127 (3%)
Query: 160 LRVQRNAEELGHE---AFWEQELRREQAREREGQARLQALSAATAEHAARLQALDAQARA 216
LR++ AEE+ + A E E ++E+A ERE + R +A A + Q L+ Q +
Sbjct: 1642 LRLRLQAEEVAQQKSLAQAEAEKQKEEA-EREARRRGKAEEQAVRQRELAEQELEKQRQL 1700
Query: 217 LEAELQLAAEAPGPPSPMASATERLHQDLAVQERQSAEVQGSLALVSRALEAAERALQAQ 276
E Q A + + TE+ Q + E + A +Q A ++ + E L
Sbjct: 1701 AEGTAQQRLAAEQELIRLRAETEQGEQQRQLLEEELARLQREAAAATQKRQELEAELAKV 1760
Query: 277 AQELEEL 283
E+E L
Sbjct: 1761 RAEMEVL 1767
Score = 33.1 bits (74), Expect = 0.34
Identities = 32/126 (25%), Positives = 59/126 (46%), Gaps = 9/126 (7%)
Query: 177 QELRREQAREREGQARLQALSAATAEHAARLQALD----AQARAL-EAELQLAAEAPGPP 231
Q +E+A + + A A + A+ AARL+ L AQ RAL E L+ +A
Sbjct: 2263 QRFLQEEAEKMKQVAEEAARLSVAAQEAARLRQLAEEDLAQQRALAEKMLKEKMQAVQEA 2322
Query: 232 SPMASATERLHQDLAVQERQSAEVQGSLALVSRAL----EAAERALQAQAQELEELNREL 287
+ + + E L Q + + Q+ +Q +++ L + +R L+A+ Q E++ E
Sbjct: 2323 TRLKAEAELLQQQKELAQEQARRLQEDKEQMAQQLAEETQGFQRTLEAERQRQLEMSAEA 2382
Query: 288 RQCNLQ 293
+ L+
Sbjct: 2383 ERLKLR 2388
Score = 32.3 bits (72), Expect = 0.58
Identities = 20/65 (30%), Positives = 35/65 (53%), Gaps = 2/65 (3%)
Query: 234 MASATERLHQDLAVQERQSAEVQGSLALVSRALEAAERALQAQAQELEELNRELRQCNLQ 293
++ R+ ++ + E+Q AE + LA V ALE + +A AQ + RE ++ LQ
Sbjct: 1337 ISETLRRMEEEERLAEQQRAEERERLAEVEAALEKQRQLAEAHAQAKAQAEREAKE--LQ 1394
Query: 294 QFIQQ 298
Q +Q+
Sbjct: 1395 QRMQE 1399
Score = 29.3 bits (64), Expect = 4.9
Identities = 45/183 (24%), Positives = 74/183 (40%), Gaps = 25/183 (13%)
Query: 118 AALGCEPRKTLT-PEPAPSLSRPGPAAPVTPTPGCCTDLRGLELRVQRNAEEL-----GH 171
A L E K L PEP+P+ P + + T G +R L + + G
Sbjct: 1041 ARLSAEAEKVLALPEPSPAA--PTLRSELELTLGKLEQVRSLSAIYLEKLKTISLVIRGT 1098
Query: 172 EAFWEQELRREQAREREGQA------RLQALSAATAEHAARLQALDAQARALEAELQLAA 225
+ E+ LR + + +E QA L+A A+ + A+ +A AL EL+ A
Sbjct: 1099 QGA-EEVLRAHEEQLKEAQAVPATLPELEATKASLKKLRAQAEAQQPTFDALRDELRGAQ 1157
Query: 226 EAPGPPSPMASATERLHQDLAVQERQSAEVQGSLALVSRALEAAERALQAQAQELEELNR 285
E ERL Q ++ + + +A + +A + +ELE+L R
Sbjct: 1158 EVG----------ERLQQRHGERDVEVERWRERVAQLLERWQAVLAQTDVRQRELEQLGR 1207
Query: 286 ELR 288
+LR
Sbjct: 1208 QLR 1210
Score = 28.5 bits (62), Expect = 8.3
Identities = 34/129 (26%), Positives = 58/129 (44%), Gaps = 16/129 (12%)
Query: 176 EQELRREQA-REREGQARLQALSAATAEHAA------RLQALDAQARALEAEL-----QL 223
E++L +++A E+ + ++QA+ AT A + + QAR L+ + QL
Sbjct: 2298 EEDLAQQRALAEKMLKEKMQAVQEATRLKAEAELLQQQKELAQEQARRLQEDKEQMAQQL 2357
Query: 224 AAEAPGPPSPMASATERLHQDLAVQERQSAEVQGSLALVSRALEAAERALQAQAQELEEL 283
A E G + + +R + A ER V A +SRA AE Q ++ EE+
Sbjct: 2358 AEETQGFQRTLEAERQRQLEMSAEAERLKLRV----AEMSRAQARAEEDAQRFRKQAEEI 2413
Query: 284 NRELRQCNL 292
+L + L
Sbjct: 2414 GEKLHRTEL 2422
>gi|41322914 plectin 1 isoform 10 [Homo sapiens]
Length = 4551
Score = 42.7 bits (99), Expect = 4e-04
Identities = 78/296 (26%), Positives = 121/296 (40%), Gaps = 37/296 (12%)
Query: 31 QEVVIALAQAIGQTGRFVLVQRLREKERQLLPQECPVGAQATCGQFASDVQF-----VLR 85
+E +A Q + R V+ EK+RQL AQA + A ++Q V+R
Sbjct: 1350 EEERLAEQQRAEERERLAEVEAALEKQRQLAEAHAQAKAQAE--REAKELQQRMQEEVVR 1407
Query: 86 RTGPSLAGRPSSDSCPPPERCLIRAS---LPVKPRAALGCEPRKTLTPEPAPSLSRPGPA 142
R ++ + S + L ++S + K R A E R L E + R
Sbjct: 1408 REEAAVDAQQQKRSIQEELQQLRQSSEAEIQAKARQAEAAE-RSRLRIEEEIRVVRLQLE 1466
Query: 143 APVTPTPGCCTDLRGLELRVQRNAEELGHEAFWEQELRREQARE---REGQARLQALSAA 199
A G +L+ L R + AE +A E E R Q ++ R+ QA ++ S
Sbjct: 1467 ATERQRGGAEGELQALRARAEE-AEAQKRQAQEEAERLRRQVQDESQRKRQAEVELASRV 1525
Query: 200 TAEHAA--------------RLQALDAQARALEAELQLAAEAP-GPPSPMASATERLHQD 244
AE A RLQA +A+ R +AE++ A + + SA L
Sbjct: 1526 KAEAEAAREKQRALQALEELRLQAEEAERRLRQAEVERARQVQVALETAQRSAEAELQSK 1585
Query: 245 LAVQERQSAEVQGSL----ALVSRALEAAERALQAQAQ---ELEELNRELRQCNLQ 293
A ++A+++ SL V++ E AER Q QA+ EE REL + L+
Sbjct: 1586 RASFAEKTAQLERSLQEEHVAVAQLREEAERRAQQQAEAERAREEAERELERWQLK 1641
Score = 40.4 bits (93), Expect = 0.002
Identities = 40/137 (29%), Positives = 57/137 (41%), Gaps = 9/137 (6%)
Query: 159 ELRVQRNAEELGHEAFWEQELRREQAREREGQARLQALSAATAEHAARLQALDAQARALE 218
E RVQ E E+ R +Q+ E + QAR QA +AA R +A AR +
Sbjct: 2099 EARVQAEREAAQSRRQVEEAERLKQSAEEQAQARAQAQAAA---EKLRKEAEQEAARRAQ 2155
Query: 219 AELQLAAEAPGPPSPMASATERLHQDLAVQE-RQSAEVQGSLALVSRALEAAERALQAQA 277
AE +A A A H+ A Q RQ A+V+ L + LE +
Sbjct: 2156 AE-----QAALRQKQAADAEMEKHKKFAEQTLRQKAQVEQELTTLRLQLEETDHQKNLLD 2210
Query: 278 QELEELNRELRQCNLQQ 294
+EL+ L E + Q+
Sbjct: 2211 EELQRLKAEATEAARQR 2227
Score = 35.8 bits (81), Expect = 0.052
Identities = 34/127 (26%), Positives = 56/127 (44%), Gaps = 4/127 (3%)
Query: 160 LRVQRNAEELGHE---AFWEQELRREQAREREGQARLQALSAATAEHAARLQALDAQARA 216
LR++ AEE+ + A E E ++E+A ERE + R +A A + Q L+ Q +
Sbjct: 1646 LRLRLQAEEVAQQKSLAQAEAEKQKEEA-EREARRRGKAEEQAVRQRELAEQELEKQRQL 1704
Query: 217 LEAELQLAAEAPGPPSPMASATERLHQDLAVQERQSAEVQGSLALVSRALEAAERALQAQ 276
E Q A + + TE+ Q + E + A +Q A ++ + E L
Sbjct: 1705 AEGTAQQRLAAEQELIRLRAETEQGEQQRQLLEEELARLQREAAAATQKRQELEAELAKV 1764
Query: 277 AQELEEL 283
E+E L
Sbjct: 1765 RAEMEVL 1771
Score = 33.1 bits (74), Expect = 0.34
Identities = 32/126 (25%), Positives = 59/126 (46%), Gaps = 9/126 (7%)
Query: 177 QELRREQAREREGQARLQALSAATAEHAARLQALD----AQARAL-EAELQLAAEAPGPP 231
Q +E+A + + A A + A+ AARL+ L AQ RAL E L+ +A
Sbjct: 2267 QRFLQEEAEKMKQVAEEAARLSVAAQEAARLRQLAEEDLAQQRALAEKMLKEKMQAVQEA 2326
Query: 232 SPMASATERLHQDLAVQERQSAEVQGSLALVSRAL----EAAERALQAQAQELEELNREL 287
+ + + E L Q + + Q+ +Q +++ L + +R L+A+ Q E++ E
Sbjct: 2327 TRLKAEAELLQQQKELAQEQARRLQEDKEQMAQQLAEETQGFQRTLEAERQRQLEMSAEA 2386
Query: 288 RQCNLQ 293
+ L+
Sbjct: 2387 ERLKLR 2392
Score = 32.3 bits (72), Expect = 0.58
Identities = 20/65 (30%), Positives = 35/65 (53%), Gaps = 2/65 (3%)
Query: 234 MASATERLHQDLAVQERQSAEVQGSLALVSRALEAAERALQAQAQELEELNRELRQCNLQ 293
++ R+ ++ + E+Q AE + LA V ALE + +A AQ + RE ++ LQ
Sbjct: 1341 ISETLRRMEEEERLAEQQRAEERERLAEVEAALEKQRQLAEAHAQAKAQAEREAKE--LQ 1398
Query: 294 QFIQQ 298
Q +Q+
Sbjct: 1399 QRMQE 1403
Score = 29.3 bits (64), Expect = 4.9
Identities = 45/183 (24%), Positives = 74/183 (40%), Gaps = 25/183 (13%)
Query: 118 AALGCEPRKTLT-PEPAPSLSRPGPAAPVTPTPGCCTDLRGLELRVQRNAEEL-----GH 171
A L E K L PEP+P+ P + + T G +R L + + G
Sbjct: 1045 ARLSAEAEKVLALPEPSPAA--PTLRSELELTLGKLEQVRSLSAIYLEKLKTISLVIRGT 1102
Query: 172 EAFWEQELRREQAREREGQA------RLQALSAATAEHAARLQALDAQARALEAELQLAA 225
+ E+ LR + + +E QA L+A A+ + A+ +A AL EL+ A
Sbjct: 1103 QGA-EEVLRAHEEQLKEAQAVPATLPELEATKASLKKLRAQAEAQQPTFDALRDELRGAQ 1161
Query: 226 EAPGPPSPMASATERLHQDLAVQERQSAEVQGSLALVSRALEAAERALQAQAQELEELNR 285
E ERL Q ++ + + +A + +A + +ELE+L R
Sbjct: 1162 EVG----------ERLQQRHGERDVEVERWRERVAQLLERWQAVLAQTDVRQRELEQLGR 1211
Query: 286 ELR 288
+LR
Sbjct: 1212 QLR 1214
Score = 28.5 bits (62), Expect = 8.3
Identities = 34/129 (26%), Positives = 58/129 (44%), Gaps = 16/129 (12%)
Query: 176 EQELRREQA-REREGQARLQALSAATAEHAA------RLQALDAQARALEAEL-----QL 223
E++L +++A E+ + ++QA+ AT A + + QAR L+ + QL
Sbjct: 2302 EEDLAQQRALAEKMLKEKMQAVQEATRLKAEAELLQQQKELAQEQARRLQEDKEQMAQQL 2361
Query: 224 AAEAPGPPSPMASATERLHQDLAVQERQSAEVQGSLALVSRALEAAERALQAQAQELEEL 283
A E G + + +R + A ER V A +SRA AE Q ++ EE+
Sbjct: 2362 AEETQGFQRTLEAERQRQLEMSAEAERLKLRV----AEMSRAQARAEEDAQRFRKQAEEI 2417
Query: 284 NRELRQCNL 292
+L + L
Sbjct: 2418 GEKLHRTEL 2426
>gi|41322919 plectin 1 isoform 8 [Homo sapiens]
Length = 4547
Score = 42.7 bits (99), Expect = 4e-04
Identities = 78/296 (26%), Positives = 121/296 (40%), Gaps = 37/296 (12%)
Query: 31 QEVVIALAQAIGQTGRFVLVQRLREKERQLLPQECPVGAQATCGQFASDVQF-----VLR 85
+E +A Q + R V+ EK+RQL AQA + A ++Q V+R
Sbjct: 1346 EEERLAEQQRAEERERLAEVEAALEKQRQLAEAHAQAKAQAE--REAKELQQRMQEEVVR 1403
Query: 86 RTGPSLAGRPSSDSCPPPERCLIRAS---LPVKPRAALGCEPRKTLTPEPAPSLSRPGPA 142
R ++ + S + L ++S + K R A E R L E + R
Sbjct: 1404 REEAAVDAQQQKRSIQEELQQLRQSSEAEIQAKARQAEAAE-RSRLRIEEEIRVVRLQLE 1462
Query: 143 APVTPTPGCCTDLRGLELRVQRNAEELGHEAFWEQELRREQARE---REGQARLQALSAA 199
A G +L+ L R + AE +A E E R Q ++ R+ QA ++ S
Sbjct: 1463 ATERQRGGAEGELQALRARAEE-AEAQKRQAQEEAERLRRQVQDESQRKRQAEVELASRV 1521
Query: 200 TAEHAA--------------RLQALDAQARALEAELQLAAEAP-GPPSPMASATERLHQD 244
AE A RLQA +A+ R +AE++ A + + SA L
Sbjct: 1522 KAEAEAAREKQRALQALEELRLQAEEAERRLRQAEVERARQVQVALETAQRSAEAELQSK 1581
Query: 245 LAVQERQSAEVQGSL----ALVSRALEAAERALQAQAQ---ELEELNRELRQCNLQ 293
A ++A+++ SL V++ E AER Q QA+ EE REL + L+
Sbjct: 1582 RASFAEKTAQLERSLQEEHVAVAQLREEAERRAQQQAEAERAREEAERELERWQLK 1637
Score = 40.4 bits (93), Expect = 0.002
Identities = 40/137 (29%), Positives = 57/137 (41%), Gaps = 9/137 (6%)
Query: 159 ELRVQRNAEELGHEAFWEQELRREQAREREGQARLQALSAATAEHAARLQALDAQARALE 218
E RVQ E E+ R +Q+ E + QAR QA +AA R +A AR +
Sbjct: 2095 EARVQAEREAAQSRRQVEEAERLKQSAEEQAQARAQAQAAA---EKLRKEAEQEAARRAQ 2151
Query: 219 AELQLAAEAPGPPSPMASATERLHQDLAVQE-RQSAEVQGSLALVSRALEAAERALQAQA 277
AE +A A A H+ A Q RQ A+V+ L + LE +
Sbjct: 2152 AE-----QAALRQKQAADAEMEKHKKFAEQTLRQKAQVEQELTTLRLQLEETDHQKNLLD 2206
Query: 278 QELEELNRELRQCNLQQ 294
+EL+ L E + Q+
Sbjct: 2207 EELQRLKAEATEAARQR 2223
Score = 35.8 bits (81), Expect = 0.052
Identities = 34/127 (26%), Positives = 56/127 (44%), Gaps = 4/127 (3%)
Query: 160 LRVQRNAEELGHE---AFWEQELRREQAREREGQARLQALSAATAEHAARLQALDAQARA 216
LR++ AEE+ + A E E ++E+A ERE + R +A A + Q L+ Q +
Sbjct: 1642 LRLRLQAEEVAQQKSLAQAEAEKQKEEA-EREARRRGKAEEQAVRQRELAEQELEKQRQL 1700
Query: 217 LEAELQLAAEAPGPPSPMASATERLHQDLAVQERQSAEVQGSLALVSRALEAAERALQAQ 276
E Q A + + TE+ Q + E + A +Q A ++ + E L
Sbjct: 1701 AEGTAQQRLAAEQELIRLRAETEQGEQQRQLLEEELARLQREAAAATQKRQELEAELAKV 1760
Query: 277 AQELEEL 283
E+E L
Sbjct: 1761 RAEMEVL 1767
Score = 33.1 bits (74), Expect = 0.34
Identities = 32/126 (25%), Positives = 59/126 (46%), Gaps = 9/126 (7%)
Query: 177 QELRREQAREREGQARLQALSAATAEHAARLQALD----AQARAL-EAELQLAAEAPGPP 231
Q +E+A + + A A + A+ AARL+ L AQ RAL E L+ +A
Sbjct: 2263 QRFLQEEAEKMKQVAEEAARLSVAAQEAARLRQLAEEDLAQQRALAEKMLKEKMQAVQEA 2322
Query: 232 SPMASATERLHQDLAVQERQSAEVQGSLALVSRAL----EAAERALQAQAQELEELNREL 287
+ + + E L Q + + Q+ +Q +++ L + +R L+A+ Q E++ E
Sbjct: 2323 TRLKAEAELLQQQKELAQEQARRLQEDKEQMAQQLAEETQGFQRTLEAERQRQLEMSAEA 2382
Query: 288 RQCNLQ 293
+ L+
Sbjct: 2383 ERLKLR 2388
Score = 32.3 bits (72), Expect = 0.58
Identities = 20/65 (30%), Positives = 35/65 (53%), Gaps = 2/65 (3%)
Query: 234 MASATERLHQDLAVQERQSAEVQGSLALVSRALEAAERALQAQAQELEELNRELRQCNLQ 293
++ R+ ++ + E+Q AE + LA V ALE + +A AQ + RE ++ LQ
Sbjct: 1337 ISETLRRMEEEERLAEQQRAEERERLAEVEAALEKQRQLAEAHAQAKAQAEREAKE--LQ 1394
Query: 294 QFIQQ 298
Q +Q+
Sbjct: 1395 QRMQE 1399
Score = 29.3 bits (64), Expect = 4.9
Identities = 45/183 (24%), Positives = 74/183 (40%), Gaps = 25/183 (13%)
Query: 118 AALGCEPRKTLT-PEPAPSLSRPGPAAPVTPTPGCCTDLRGLELRVQRNAEEL-----GH 171
A L E K L PEP+P+ P + + T G +R L + + G
Sbjct: 1041 ARLSAEAEKVLALPEPSPAA--PTLRSELELTLGKLEQVRSLSAIYLEKLKTISLVIRGT 1098
Query: 172 EAFWEQELRREQAREREGQA------RLQALSAATAEHAARLQALDAQARALEAELQLAA 225
+ E+ LR + + +E QA L+A A+ + A+ +A AL EL+ A
Sbjct: 1099 QGA-EEVLRAHEEQLKEAQAVPATLPELEATKASLKKLRAQAEAQQPTFDALRDELRGAQ 1157
Query: 226 EAPGPPSPMASATERLHQDLAVQERQSAEVQGSLALVSRALEAAERALQAQAQELEELNR 285
E ERL Q ++ + + +A + +A + +ELE+L R
Sbjct: 1158 EVG----------ERLQQRHGERDVEVERWRERVAQLLERWQAVLAQTDVRQRELEQLGR 1207
Query: 286 ELR 288
+LR
Sbjct: 1208 QLR 1210
Score = 28.5 bits (62), Expect = 8.3
Identities = 34/129 (26%), Positives = 58/129 (44%), Gaps = 16/129 (12%)
Query: 176 EQELRREQA-REREGQARLQALSAATAEHAA------RLQALDAQARALEAEL-----QL 223
E++L +++A E+ + ++QA+ AT A + + QAR L+ + QL
Sbjct: 2298 EEDLAQQRALAEKMLKEKMQAVQEATRLKAEAELLQQQKELAQEQARRLQEDKEQMAQQL 2357
Query: 224 AAEAPGPPSPMASATERLHQDLAVQERQSAEVQGSLALVSRALEAAERALQAQAQELEEL 283
A E G + + +R + A ER V A +SRA AE Q ++ EE+
Sbjct: 2358 AEETQGFQRTLEAERQRQLEMSAEAERLKLRV----AEMSRAQARAEEDAQRFRKQAEEI 2413
Query: 284 NRELRQCNL 292
+L + L
Sbjct: 2414 GEKLHRTEL 2422
>gi|41322910 plectin 1 isoform 7 [Homo sapiens]
Length = 4515
Score = 42.7 bits (99), Expect = 4e-04
Identities = 78/296 (26%), Positives = 121/296 (40%), Gaps = 37/296 (12%)
Query: 31 QEVVIALAQAIGQTGRFVLVQRLREKERQLLPQECPVGAQATCGQFASDVQF-----VLR 85
+E +A Q + R V+ EK+RQL AQA + A ++Q V+R
Sbjct: 1314 EEERLAEQQRAEERERLAEVEAALEKQRQLAEAHAQAKAQAE--REAKELQQRMQEEVVR 1371
Query: 86 RTGPSLAGRPSSDSCPPPERCLIRAS---LPVKPRAALGCEPRKTLTPEPAPSLSRPGPA 142
R ++ + S + L ++S + K R A E R L E + R
Sbjct: 1372 REEAAVDAQQQKRSIQEELQQLRQSSEAEIQAKARQAEAAE-RSRLRIEEEIRVVRLQLE 1430
Query: 143 APVTPTPGCCTDLRGLELRVQRNAEELGHEAFWEQELRREQARE---REGQARLQALSAA 199
A G +L+ L R + AE +A E E R Q ++ R+ QA ++ S
Sbjct: 1431 ATERQRGGAEGELQALRARAEE-AEAQKRQAQEEAERLRRQVQDESQRKRQAEVELASRV 1489
Query: 200 TAEHAA--------------RLQALDAQARALEAELQLAAEAP-GPPSPMASATERLHQD 244
AE A RLQA +A+ R +AE++ A + + SA L
Sbjct: 1490 KAEAEAAREKQRALQALEELRLQAEEAERRLRQAEVERARQVQVALETAQRSAEAELQSK 1549
Query: 245 LAVQERQSAEVQGSL----ALVSRALEAAERALQAQAQ---ELEELNRELRQCNLQ 293
A ++A+++ SL V++ E AER Q QA+ EE REL + L+
Sbjct: 1550 RASFAEKTAQLERSLQEEHVAVAQLREEAERRAQQQAEAERAREEAERELERWQLK 1605
Score = 40.4 bits (93), Expect = 0.002
Identities = 40/137 (29%), Positives = 57/137 (41%), Gaps = 9/137 (6%)
Query: 159 ELRVQRNAEELGHEAFWEQELRREQAREREGQARLQALSAATAEHAARLQALDAQARALE 218
E RVQ E E+ R +Q+ E + QAR QA +AA R +A AR +
Sbjct: 2063 EARVQAEREAAQSRRQVEEAERLKQSAEEQAQARAQAQAAA---EKLRKEAEQEAARRAQ 2119
Query: 219 AELQLAAEAPGPPSPMASATERLHQDLAVQE-RQSAEVQGSLALVSRALEAAERALQAQA 277
AE +A A A H+ A Q RQ A+V+ L + LE +
Sbjct: 2120 AE-----QAALRQKQAADAEMEKHKKFAEQTLRQKAQVEQELTTLRLQLEETDHQKNLLD 2174
Query: 278 QELEELNRELRQCNLQQ 294
+EL+ L E + Q+
Sbjct: 2175 EELQRLKAEATEAARQR 2191
Score = 35.8 bits (81), Expect = 0.052
Identities = 34/127 (26%), Positives = 56/127 (44%), Gaps = 4/127 (3%)
Query: 160 LRVQRNAEELGHE---AFWEQELRREQAREREGQARLQALSAATAEHAARLQALDAQARA 216
LR++ AEE+ + A E E ++E+A ERE + R +A A + Q L+ Q +
Sbjct: 1610 LRLRLQAEEVAQQKSLAQAEAEKQKEEA-EREARRRGKAEEQAVRQRELAEQELEKQRQL 1668
Query: 217 LEAELQLAAEAPGPPSPMASATERLHQDLAVQERQSAEVQGSLALVSRALEAAERALQAQ 276
E Q A + + TE+ Q + E + A +Q A ++ + E L
Sbjct: 1669 AEGTAQQRLAAEQELIRLRAETEQGEQQRQLLEEELARLQREAAAATQKRQELEAELAKV 1728
Query: 277 AQELEEL 283
E+E L
Sbjct: 1729 RAEMEVL 1735
Score = 33.1 bits (74), Expect = 0.34
Identities = 32/126 (25%), Positives = 59/126 (46%), Gaps = 9/126 (7%)
Query: 177 QELRREQAREREGQARLQALSAATAEHAARLQALD----AQARAL-EAELQLAAEAPGPP 231
Q +E+A + + A A + A+ AARL+ L AQ RAL E L+ +A
Sbjct: 2231 QRFLQEEAEKMKQVAEEAARLSVAAQEAARLRQLAEEDLAQQRALAEKMLKEKMQAVQEA 2290
Query: 232 SPMASATERLHQDLAVQERQSAEVQGSLALVSRAL----EAAERALQAQAQELEELNREL 287
+ + + E L Q + + Q+ +Q +++ L + +R L+A+ Q E++ E
Sbjct: 2291 TRLKAEAELLQQQKELAQEQARRLQEDKEQMAQQLAEETQGFQRTLEAERQRQLEMSAEA 2350
Query: 288 RQCNLQ 293
+ L+
Sbjct: 2351 ERLKLR 2356
Score = 32.3 bits (72), Expect = 0.58
Identities = 20/65 (30%), Positives = 35/65 (53%), Gaps = 2/65 (3%)
Query: 234 MASATERLHQDLAVQERQSAEVQGSLALVSRALEAAERALQAQAQELEELNRELRQCNLQ 293
++ R+ ++ + E+Q AE + LA V ALE + +A AQ + RE ++ LQ
Sbjct: 1305 ISETLRRMEEEERLAEQQRAEERERLAEVEAALEKQRQLAEAHAQAKAQAEREAKE--LQ 1362
Query: 294 QFIQQ 298
Q +Q+
Sbjct: 1363 QRMQE 1367
Score = 29.3 bits (64), Expect = 4.9
Identities = 45/183 (24%), Positives = 74/183 (40%), Gaps = 25/183 (13%)
Query: 118 AALGCEPRKTLT-PEPAPSLSRPGPAAPVTPTPGCCTDLRGLELRVQRNAEEL-----GH 171
A L E K L PEP+P+ P + + T G +R L + + G
Sbjct: 1009 ARLSAEAEKVLALPEPSPAA--PTLRSELELTLGKLEQVRSLSAIYLEKLKTISLVIRGT 1066
Query: 172 EAFWEQELRREQAREREGQA------RLQALSAATAEHAARLQALDAQARALEAELQLAA 225
+ E+ LR + + +E QA L+A A+ + A+ +A AL EL+ A
Sbjct: 1067 QGA-EEVLRAHEEQLKEAQAVPATLPELEATKASLKKLRAQAEAQQPTFDALRDELRGAQ 1125
Query: 226 EAPGPPSPMASATERLHQDLAVQERQSAEVQGSLALVSRALEAAERALQAQAQELEELNR 285
E ERL Q ++ + + +A + +A + +ELE+L R
Sbjct: 1126 EVG----------ERLQQRHGERDVEVERWRERVAQLLERWQAVLAQTDVRQRELEQLGR 1175
Query: 286 ELR 288
+LR
Sbjct: 1176 QLR 1178
Score = 28.5 bits (62), Expect = 8.3
Identities = 34/129 (26%), Positives = 58/129 (44%), Gaps = 16/129 (12%)
Query: 176 EQELRREQA-REREGQARLQALSAATAEHAA------RLQALDAQARALEAEL-----QL 223
E++L +++A E+ + ++QA+ AT A + + QAR L+ + QL
Sbjct: 2266 EEDLAQQRALAEKMLKEKMQAVQEATRLKAEAELLQQQKELAQEQARRLQEDKEQMAQQL 2325
Query: 224 AAEAPGPPSPMASATERLHQDLAVQERQSAEVQGSLALVSRALEAAERALQAQAQELEEL 283
A E G + + +R + A ER V A +SRA AE Q ++ EE+
Sbjct: 2326 AEETQGFQRTLEAERQRQLEMSAEAERLKLRV----AEMSRAQARAEEDAQRFRKQAEEI 2381
Query: 284 NRELRQCNL 292
+L + L
Sbjct: 2382 GEKLHRTEL 2390
>gi|41322916 plectin 1 isoform 6 [Homo sapiens]
Length = 4684
Score = 42.7 bits (99), Expect = 4e-04
Identities = 78/296 (26%), Positives = 121/296 (40%), Gaps = 37/296 (12%)
Query: 31 QEVVIALAQAIGQTGRFVLVQRLREKERQLLPQECPVGAQATCGQFASDVQF-----VLR 85
+E +A Q + R V+ EK+RQL AQA + A ++Q V+R
Sbjct: 1483 EEERLAEQQRAEERERLAEVEAALEKQRQLAEAHAQAKAQAE--REAKELQQRMQEEVVR 1540
Query: 86 RTGPSLAGRPSSDSCPPPERCLIRAS---LPVKPRAALGCEPRKTLTPEPAPSLSRPGPA 142
R ++ + S + L ++S + K R A E R L E + R
Sbjct: 1541 REEAAVDAQQQKRSIQEELQQLRQSSEAEIQAKARQAEAAE-RSRLRIEEEIRVVRLQLE 1599
Query: 143 APVTPTPGCCTDLRGLELRVQRNAEELGHEAFWEQELRREQARE---REGQARLQALSAA 199
A G +L+ L R + AE +A E E R Q ++ R+ QA ++ S
Sbjct: 1600 ATERQRGGAEGELQALRARAEE-AEAQKRQAQEEAERLRRQVQDESQRKRQAEVELASRV 1658
Query: 200 TAEHAA--------------RLQALDAQARALEAELQLAAEAP-GPPSPMASATERLHQD 244
AE A RLQA +A+ R +AE++ A + + SA L
Sbjct: 1659 KAEAEAAREKQRALQALEELRLQAEEAERRLRQAEVERARQVQVALETAQRSAEAELQSK 1718
Query: 245 LAVQERQSAEVQGSL----ALVSRALEAAERALQAQAQ---ELEELNRELRQCNLQ 293
A ++A+++ SL V++ E AER Q QA+ EE REL + L+
Sbjct: 1719 RASFAEKTAQLERSLQEEHVAVAQLREEAERRAQQQAEAERAREEAERELERWQLK 1774
Score = 40.4 bits (93), Expect = 0.002
Identities = 40/137 (29%), Positives = 57/137 (41%), Gaps = 9/137 (6%)
Query: 159 ELRVQRNAEELGHEAFWEQELRREQAREREGQARLQALSAATAEHAARLQALDAQARALE 218
E RVQ E E+ R +Q+ E + QAR QA +AA R +A AR +
Sbjct: 2232 EARVQAEREAAQSRRQVEEAERLKQSAEEQAQARAQAQAAA---EKLRKEAEQEAARRAQ 2288
Query: 219 AELQLAAEAPGPPSPMASATERLHQDLAVQE-RQSAEVQGSLALVSRALEAAERALQAQA 277
AE +A A A H+ A Q RQ A+V+ L + LE +
Sbjct: 2289 AE-----QAALRQKQAADAEMEKHKKFAEQTLRQKAQVEQELTTLRLQLEETDHQKNLLD 2343
Query: 278 QELEELNRELRQCNLQQ 294
+EL+ L E + Q+
Sbjct: 2344 EELQRLKAEATEAARQR 2360
Score = 35.8 bits (81), Expect = 0.052
Identities = 34/127 (26%), Positives = 56/127 (44%), Gaps = 4/127 (3%)
Query: 160 LRVQRNAEELGHE---AFWEQELRREQAREREGQARLQALSAATAEHAARLQALDAQARA 216
LR++ AEE+ + A E E ++E+A ERE + R +A A + Q L+ Q +
Sbjct: 1779 LRLRLQAEEVAQQKSLAQAEAEKQKEEA-EREARRRGKAEEQAVRQRELAEQELEKQRQL 1837
Query: 217 LEAELQLAAEAPGPPSPMASATERLHQDLAVQERQSAEVQGSLALVSRALEAAERALQAQ 276
E Q A + + TE+ Q + E + A +Q A ++ + E L
Sbjct: 1838 AEGTAQQRLAAEQELIRLRAETEQGEQQRQLLEEELARLQREAAAATQKRQELEAELAKV 1897
Query: 277 AQELEEL 283
E+E L
Sbjct: 1898 RAEMEVL 1904
Score = 33.1 bits (74), Expect = 0.34
Identities = 32/126 (25%), Positives = 59/126 (46%), Gaps = 9/126 (7%)
Query: 177 QELRREQAREREGQARLQALSAATAEHAARLQALD----AQARAL-EAELQLAAEAPGPP 231
Q +E+A + + A A + A+ AARL+ L AQ RAL E L+ +A
Sbjct: 2400 QRFLQEEAEKMKQVAEEAARLSVAAQEAARLRQLAEEDLAQQRALAEKMLKEKMQAVQEA 2459
Query: 232 SPMASATERLHQDLAVQERQSAEVQGSLALVSRAL----EAAERALQAQAQELEELNREL 287
+ + + E L Q + + Q+ +Q +++ L + +R L+A+ Q E++ E
Sbjct: 2460 TRLKAEAELLQQQKELAQEQARRLQEDKEQMAQQLAEETQGFQRTLEAERQRQLEMSAEA 2519
Query: 288 RQCNLQ 293
+ L+
Sbjct: 2520 ERLKLR 2525
Score = 32.3 bits (72), Expect = 0.58
Identities = 20/65 (30%), Positives = 35/65 (53%), Gaps = 2/65 (3%)
Query: 234 MASATERLHQDLAVQERQSAEVQGSLALVSRALEAAERALQAQAQELEELNRELRQCNLQ 293
++ R+ ++ + E+Q AE + LA V ALE + +A AQ + RE ++ LQ
Sbjct: 1474 ISETLRRMEEEERLAEQQRAEERERLAEVEAALEKQRQLAEAHAQAKAQAEREAKE--LQ 1531
Query: 294 QFIQQ 298
Q +Q+
Sbjct: 1532 QRMQE 1536
Score = 29.3 bits (64), Expect = 4.9
Identities = 45/183 (24%), Positives = 74/183 (40%), Gaps = 25/183 (13%)
Query: 118 AALGCEPRKTLT-PEPAPSLSRPGPAAPVTPTPGCCTDLRGLELRVQRNAEEL-----GH 171
A L E K L PEP+P+ P + + T G +R L + + G
Sbjct: 1178 ARLSAEAEKVLALPEPSPAA--PTLRSELELTLGKLEQVRSLSAIYLEKLKTISLVIRGT 1235
Query: 172 EAFWEQELRREQAREREGQA------RLQALSAATAEHAARLQALDAQARALEAELQLAA 225
+ E+ LR + + +E QA L+A A+ + A+ +A AL EL+ A
Sbjct: 1236 QGA-EEVLRAHEEQLKEAQAVPATLPELEATKASLKKLRAQAEAQQPTFDALRDELRGAQ 1294
Query: 226 EAPGPPSPMASATERLHQDLAVQERQSAEVQGSLALVSRALEAAERALQAQAQELEELNR 285
E ERL Q ++ + + +A + +A + +ELE+L R
Sbjct: 1295 EVG----------ERLQQRHGERDVEVERWRERVAQLLERWQAVLAQTDVRQRELEQLGR 1344
Query: 286 ELR 288
+LR
Sbjct: 1345 QLR 1347
Score = 28.5 bits (62), Expect = 8.3
Identities = 34/129 (26%), Positives = 58/129 (44%), Gaps = 16/129 (12%)
Query: 176 EQELRREQA-REREGQARLQALSAATAEHAA------RLQALDAQARALEAEL-----QL 223
E++L +++A E+ + ++QA+ AT A + + QAR L+ + QL
Sbjct: 2435 EEDLAQQRALAEKMLKEKMQAVQEATRLKAEAELLQQQKELAQEQARRLQEDKEQMAQQL 2494
Query: 224 AAEAPGPPSPMASATERLHQDLAVQERQSAEVQGSLALVSRALEAAERALQAQAQELEEL 283
A E G + + +R + A ER V A +SRA AE Q ++ EE+
Sbjct: 2495 AEETQGFQRTLEAERQRQLEMSAEAERLKLRV----AEMSRAQARAEEDAQRFRKQAEEI 2550
Query: 284 NRELRQCNL 292
+L + L
Sbjct: 2551 GEKLHRTEL 2559
>gi|41322908 plectin 1 isoform 3 [Homo sapiens]
Length = 4525
Score = 42.7 bits (99), Expect = 4e-04
Identities = 78/296 (26%), Positives = 121/296 (40%), Gaps = 37/296 (12%)
Query: 31 QEVVIALAQAIGQTGRFVLVQRLREKERQLLPQECPVGAQATCGQFASDVQF-----VLR 85
+E +A Q + R V+ EK+RQL AQA + A ++Q V+R
Sbjct: 1324 EEERLAEQQRAEERERLAEVEAALEKQRQLAEAHAQAKAQAE--REAKELQQRMQEEVVR 1381
Query: 86 RTGPSLAGRPSSDSCPPPERCLIRAS---LPVKPRAALGCEPRKTLTPEPAPSLSRPGPA 142
R ++ + S + L ++S + K R A E R L E + R
Sbjct: 1382 REEAAVDAQQQKRSIQEELQQLRQSSEAEIQAKARQAEAAE-RSRLRIEEEIRVVRLQLE 1440
Query: 143 APVTPTPGCCTDLRGLELRVQRNAEELGHEAFWEQELRREQARE---REGQARLQALSAA 199
A G +L+ L R + AE +A E E R Q ++ R+ QA ++ S
Sbjct: 1441 ATERQRGGAEGELQALRARAEE-AEAQKRQAQEEAERLRRQVQDESQRKRQAEVELASRV 1499
Query: 200 TAEHAA--------------RLQALDAQARALEAELQLAAEAP-GPPSPMASATERLHQD 244
AE A RLQA +A+ R +AE++ A + + SA L
Sbjct: 1500 KAEAEAAREKQRALQALEELRLQAEEAERRLRQAEVERARQVQVALETAQRSAEAELQSK 1559
Query: 245 LAVQERQSAEVQGSL----ALVSRALEAAERALQAQAQ---ELEELNRELRQCNLQ 293
A ++A+++ SL V++ E AER Q QA+ EE REL + L+
Sbjct: 1560 RASFAEKTAQLERSLQEEHVAVAQLREEAERRAQQQAEAERAREEAERELERWQLK 1615
Score = 40.4 bits (93), Expect = 0.002
Identities = 40/137 (29%), Positives = 57/137 (41%), Gaps = 9/137 (6%)
Query: 159 ELRVQRNAEELGHEAFWEQELRREQAREREGQARLQALSAATAEHAARLQALDAQARALE 218
E RVQ E E+ R +Q+ E + QAR QA +AA R +A AR +
Sbjct: 2073 EARVQAEREAAQSRRQVEEAERLKQSAEEQAQARAQAQAAA---EKLRKEAEQEAARRAQ 2129
Query: 219 AELQLAAEAPGPPSPMASATERLHQDLAVQE-RQSAEVQGSLALVSRALEAAERALQAQA 277
AE +A A A H+ A Q RQ A+V+ L + LE +
Sbjct: 2130 AE-----QAALRQKQAADAEMEKHKKFAEQTLRQKAQVEQELTTLRLQLEETDHQKNLLD 2184
Query: 278 QELEELNRELRQCNLQQ 294
+EL+ L E + Q+
Sbjct: 2185 EELQRLKAEATEAARQR 2201
Score = 35.8 bits (81), Expect = 0.052
Identities = 34/127 (26%), Positives = 56/127 (44%), Gaps = 4/127 (3%)
Query: 160 LRVQRNAEELGHE---AFWEQELRREQAREREGQARLQALSAATAEHAARLQALDAQARA 216
LR++ AEE+ + A E E ++E+A ERE + R +A A + Q L+ Q +
Sbjct: 1620 LRLRLQAEEVAQQKSLAQAEAEKQKEEA-EREARRRGKAEEQAVRQRELAEQELEKQRQL 1678
Query: 217 LEAELQLAAEAPGPPSPMASATERLHQDLAVQERQSAEVQGSLALVSRALEAAERALQAQ 276
E Q A + + TE+ Q + E + A +Q A ++ + E L
Sbjct: 1679 AEGTAQQRLAAEQELIRLRAETEQGEQQRQLLEEELARLQREAAAATQKRQELEAELAKV 1738
Query: 277 AQELEEL 283
E+E L
Sbjct: 1739 RAEMEVL 1745
Score = 33.1 bits (74), Expect = 0.34
Identities = 32/126 (25%), Positives = 59/126 (46%), Gaps = 9/126 (7%)
Query: 177 QELRREQAREREGQARLQALSAATAEHAARLQALD----AQARAL-EAELQLAAEAPGPP 231
Q +E+A + + A A + A+ AARL+ L AQ RAL E L+ +A
Sbjct: 2241 QRFLQEEAEKMKQVAEEAARLSVAAQEAARLRQLAEEDLAQQRALAEKMLKEKMQAVQEA 2300
Query: 232 SPMASATERLHQDLAVQERQSAEVQGSLALVSRAL----EAAERALQAQAQELEELNREL 287
+ + + E L Q + + Q+ +Q +++ L + +R L+A+ Q E++ E
Sbjct: 2301 TRLKAEAELLQQQKELAQEQARRLQEDKEQMAQQLAEETQGFQRTLEAERQRQLEMSAEA 2360
Query: 288 RQCNLQ 293
+ L+
Sbjct: 2361 ERLKLR 2366
Score = 32.3 bits (72), Expect = 0.58
Identities = 20/65 (30%), Positives = 35/65 (53%), Gaps = 2/65 (3%)
Query: 234 MASATERLHQDLAVQERQSAEVQGSLALVSRALEAAERALQAQAQELEELNRELRQCNLQ 293
++ R+ ++ + E+Q AE + LA V ALE + +A AQ + RE ++ LQ
Sbjct: 1315 ISETLRRMEEEERLAEQQRAEERERLAEVEAALEKQRQLAEAHAQAKAQAEREAKE--LQ 1372
Query: 294 QFIQQ 298
Q +Q+
Sbjct: 1373 QRMQE 1377
Score = 29.3 bits (64), Expect = 4.9
Identities = 45/183 (24%), Positives = 74/183 (40%), Gaps = 25/183 (13%)
Query: 118 AALGCEPRKTLT-PEPAPSLSRPGPAAPVTPTPGCCTDLRGLELRVQRNAEEL-----GH 171
A L E K L PEP+P+ P + + T G +R L + + G
Sbjct: 1019 ARLSAEAEKVLALPEPSPAA--PTLRSELELTLGKLEQVRSLSAIYLEKLKTISLVIRGT 1076
Query: 172 EAFWEQELRREQAREREGQA------RLQALSAATAEHAARLQALDAQARALEAELQLAA 225
+ E+ LR + + +E QA L+A A+ + A+ +A AL EL+ A
Sbjct: 1077 QGA-EEVLRAHEEQLKEAQAVPATLPELEATKASLKKLRAQAEAQQPTFDALRDELRGAQ 1135
Query: 226 EAPGPPSPMASATERLHQDLAVQERQSAEVQGSLALVSRALEAAERALQAQAQELEELNR 285
E ERL Q ++ + + +A + +A + +ELE+L R
Sbjct: 1136 EVG----------ERLQQRHGERDVEVERWRERVAQLLERWQAVLAQTDVRQRELEQLGR 1185
Query: 286 ELR 288
+LR
Sbjct: 1186 QLR 1188
Score = 28.5 bits (62), Expect = 8.3
Identities = 34/129 (26%), Positives = 58/129 (44%), Gaps = 16/129 (12%)
Query: 176 EQELRREQA-REREGQARLQALSAATAEHAA------RLQALDAQARALEAEL-----QL 223
E++L +++A E+ + ++QA+ AT A + + QAR L+ + QL
Sbjct: 2276 EEDLAQQRALAEKMLKEKMQAVQEATRLKAEAELLQQQKELAQEQARRLQEDKEQMAQQL 2335
Query: 224 AAEAPGPPSPMASATERLHQDLAVQERQSAEVQGSLALVSRALEAAERALQAQAQELEEL 283
A E G + + +R + A ER V A +SRA AE Q ++ EE+
Sbjct: 2336 AEETQGFQRTLEAERQRQLEMSAEAERLKLRV----AEMSRAQARAEEDAQRFRKQAEEI 2391
Query: 284 NRELRQCNL 292
+L + L
Sbjct: 2392 GEKLHRTEL 2400
>gi|41322912 plectin 1 isoform 2 [Homo sapiens]
Length = 4533
Score = 42.7 bits (99), Expect = 4e-04
Identities = 78/296 (26%), Positives = 121/296 (40%), Gaps = 37/296 (12%)
Query: 31 QEVVIALAQAIGQTGRFVLVQRLREKERQLLPQECPVGAQATCGQFASDVQF-----VLR 85
+E +A Q + R V+ EK+RQL AQA + A ++Q V+R
Sbjct: 1332 EEERLAEQQRAEERERLAEVEAALEKQRQLAEAHAQAKAQAE--REAKELQQRMQEEVVR 1389
Query: 86 RTGPSLAGRPSSDSCPPPERCLIRAS---LPVKPRAALGCEPRKTLTPEPAPSLSRPGPA 142
R ++ + S + L ++S + K R A E R L E + R
Sbjct: 1390 REEAAVDAQQQKRSIQEELQQLRQSSEAEIQAKARQAEAAE-RSRLRIEEEIRVVRLQLE 1448
Query: 143 APVTPTPGCCTDLRGLELRVQRNAEELGHEAFWEQELRREQARE---REGQARLQALSAA 199
A G +L+ L R + AE +A E E R Q ++ R+ QA ++ S
Sbjct: 1449 ATERQRGGAEGELQALRARAEE-AEAQKRQAQEEAERLRRQVQDESQRKRQAEVELASRV 1507
Query: 200 TAEHAA--------------RLQALDAQARALEAELQLAAEAP-GPPSPMASATERLHQD 244
AE A RLQA +A+ R +AE++ A + + SA L
Sbjct: 1508 KAEAEAAREKQRALQALEELRLQAEEAERRLRQAEVERARQVQVALETAQRSAEAELQSK 1567
Query: 245 LAVQERQSAEVQGSL----ALVSRALEAAERALQAQAQ---ELEELNRELRQCNLQ 293
A ++A+++ SL V++ E AER Q QA+ EE REL + L+
Sbjct: 1568 RASFAEKTAQLERSLQEEHVAVAQLREEAERRAQQQAEAERAREEAERELERWQLK 1623
Score = 40.4 bits (93), Expect = 0.002
Identities = 40/137 (29%), Positives = 57/137 (41%), Gaps = 9/137 (6%)
Query: 159 ELRVQRNAEELGHEAFWEQELRREQAREREGQARLQALSAATAEHAARLQALDAQARALE 218
E RVQ E E+ R +Q+ E + QAR QA +AA R +A AR +
Sbjct: 2081 EARVQAEREAAQSRRQVEEAERLKQSAEEQAQARAQAQAAA---EKLRKEAEQEAARRAQ 2137
Query: 219 AELQLAAEAPGPPSPMASATERLHQDLAVQE-RQSAEVQGSLALVSRALEAAERALQAQA 277
AE +A A A H+ A Q RQ A+V+ L + LE +
Sbjct: 2138 AE-----QAALRQKQAADAEMEKHKKFAEQTLRQKAQVEQELTTLRLQLEETDHQKNLLD 2192
Query: 278 QELEELNRELRQCNLQQ 294
+EL+ L E + Q+
Sbjct: 2193 EELQRLKAEATEAARQR 2209
Score = 35.8 bits (81), Expect = 0.052
Identities = 34/127 (26%), Positives = 56/127 (44%), Gaps = 4/127 (3%)
Query: 160 LRVQRNAEELGHE---AFWEQELRREQAREREGQARLQALSAATAEHAARLQALDAQARA 216
LR++ AEE+ + A E E ++E+A ERE + R +A A + Q L+ Q +
Sbjct: 1628 LRLRLQAEEVAQQKSLAQAEAEKQKEEA-EREARRRGKAEEQAVRQRELAEQELEKQRQL 1686
Query: 217 LEAELQLAAEAPGPPSPMASATERLHQDLAVQERQSAEVQGSLALVSRALEAAERALQAQ 276
E Q A + + TE+ Q + E + A +Q A ++ + E L
Sbjct: 1687 AEGTAQQRLAAEQELIRLRAETEQGEQQRQLLEEELARLQREAAAATQKRQELEAELAKV 1746
Query: 277 AQELEEL 283
E+E L
Sbjct: 1747 RAEMEVL 1753
Score = 33.1 bits (74), Expect = 0.34
Identities = 32/126 (25%), Positives = 59/126 (46%), Gaps = 9/126 (7%)
Query: 177 QELRREQAREREGQARLQALSAATAEHAARLQALD----AQARAL-EAELQLAAEAPGPP 231
Q +E+A + + A A + A+ AARL+ L AQ RAL E L+ +A
Sbjct: 2249 QRFLQEEAEKMKQVAEEAARLSVAAQEAARLRQLAEEDLAQQRALAEKMLKEKMQAVQEA 2308
Query: 232 SPMASATERLHQDLAVQERQSAEVQGSLALVSRAL----EAAERALQAQAQELEELNREL 287
+ + + E L Q + + Q+ +Q +++ L + +R L+A+ Q E++ E
Sbjct: 2309 TRLKAEAELLQQQKELAQEQARRLQEDKEQMAQQLAEETQGFQRTLEAERQRQLEMSAEA 2368
Query: 288 RQCNLQ 293
+ L+
Sbjct: 2369 ERLKLR 2374
Score = 32.3 bits (72), Expect = 0.58
Identities = 20/65 (30%), Positives = 35/65 (53%), Gaps = 2/65 (3%)
Query: 234 MASATERLHQDLAVQERQSAEVQGSLALVSRALEAAERALQAQAQELEELNRELRQCNLQ 293
++ R+ ++ + E+Q AE + LA V ALE + +A AQ + RE ++ LQ
Sbjct: 1323 ISETLRRMEEEERLAEQQRAEERERLAEVEAALEKQRQLAEAHAQAKAQAEREAKE--LQ 1380
Query: 294 QFIQQ 298
Q +Q+
Sbjct: 1381 QRMQE 1385
Score = 29.3 bits (64), Expect = 4.9
Identities = 45/183 (24%), Positives = 74/183 (40%), Gaps = 25/183 (13%)
Query: 118 AALGCEPRKTLT-PEPAPSLSRPGPAAPVTPTPGCCTDLRGLELRVQRNAEEL-----GH 171
A L E K L PEP+P+ P + + T G +R L + + G
Sbjct: 1027 ARLSAEAEKVLALPEPSPAA--PTLRSELELTLGKLEQVRSLSAIYLEKLKTISLVIRGT 1084
Query: 172 EAFWEQELRREQAREREGQA------RLQALSAATAEHAARLQALDAQARALEAELQLAA 225
+ E+ LR + + +E QA L+A A+ + A+ +A AL EL+ A
Sbjct: 1085 QGA-EEVLRAHEEQLKEAQAVPATLPELEATKASLKKLRAQAEAQQPTFDALRDELRGAQ 1143
Query: 226 EAPGPPSPMASATERLHQDLAVQERQSAEVQGSLALVSRALEAAERALQAQAQELEELNR 285
E ERL Q ++ + + +A + +A + +ELE+L R
Sbjct: 1144 EVG----------ERLQQRHGERDVEVERWRERVAQLLERWQAVLAQTDVRQRELEQLGR 1193
Query: 286 ELR 288
+LR
Sbjct: 1194 QLR 1196
Score = 28.5 bits (62), Expect = 8.3
Identities = 34/129 (26%), Positives = 58/129 (44%), Gaps = 16/129 (12%)
Query: 176 EQELRREQA-REREGQARLQALSAATAEHAA------RLQALDAQARALEAEL-----QL 223
E++L +++A E+ + ++QA+ AT A + + QAR L+ + QL
Sbjct: 2284 EEDLAQQRALAEKMLKEKMQAVQEATRLKAEAELLQQQKELAQEQARRLQEDKEQMAQQL 2343
Query: 224 AAEAPGPPSPMASATERLHQDLAVQERQSAEVQGSLALVSRALEAAERALQAQAQELEEL 283
A E G + + +R + A ER V A +SRA AE Q ++ EE+
Sbjct: 2344 AEETQGFQRTLEAERQRQLEMSAEAERLKLRV----AEMSRAQARAEEDAQRFRKQAEEI 2399
Query: 284 NRELRQCNL 292
+L + L
Sbjct: 2400 GEKLHRTEL 2408
>gi|47607492 plectin 1 isoform 1 [Homo sapiens]
Length = 4574
Score = 42.7 bits (99), Expect = 4e-04
Identities = 78/296 (26%), Positives = 121/296 (40%), Gaps = 37/296 (12%)
Query: 31 QEVVIALAQAIGQTGRFVLVQRLREKERQLLPQECPVGAQATCGQFASDVQF-----VLR 85
+E +A Q + R V+ EK+RQL AQA + A ++Q V+R
Sbjct: 1373 EEERLAEQQRAEERERLAEVEAALEKQRQLAEAHAQAKAQAE--REAKELQQRMQEEVVR 1430
Query: 86 RTGPSLAGRPSSDSCPPPERCLIRAS---LPVKPRAALGCEPRKTLTPEPAPSLSRPGPA 142
R ++ + S + L ++S + K R A E R L E + R
Sbjct: 1431 REEAAVDAQQQKRSIQEELQQLRQSSEAEIQAKARQAEAAE-RSRLRIEEEIRVVRLQLE 1489
Query: 143 APVTPTPGCCTDLRGLELRVQRNAEELGHEAFWEQELRREQARE---REGQARLQALSAA 199
A G +L+ L R + AE +A E E R Q ++ R+ QA ++ S
Sbjct: 1490 ATERQRGGAEGELQALRARAEE-AEAQKRQAQEEAERLRRQVQDESQRKRQAEVELASRV 1548
Query: 200 TAEHAA--------------RLQALDAQARALEAELQLAAEAP-GPPSPMASATERLHQD 244
AE A RLQA +A+ R +AE++ A + + SA L
Sbjct: 1549 KAEAEAAREKQRALQALEELRLQAEEAERRLRQAEVERARQVQVALETAQRSAEAELQSK 1608
Query: 245 LAVQERQSAEVQGSL----ALVSRALEAAERALQAQAQ---ELEELNRELRQCNLQ 293
A ++A+++ SL V++ E AER Q QA+ EE REL + L+
Sbjct: 1609 RASFAEKTAQLERSLQEEHVAVAQLREEAERRAQQQAEAERAREEAERELERWQLK 1664
Score = 40.4 bits (93), Expect = 0.002
Identities = 40/137 (29%), Positives = 57/137 (41%), Gaps = 9/137 (6%)
Query: 159 ELRVQRNAEELGHEAFWEQELRREQAREREGQARLQALSAATAEHAARLQALDAQARALE 218
E RVQ E E+ R +Q+ E + QAR QA +AA R +A AR +
Sbjct: 2122 EARVQAEREAAQSRRQVEEAERLKQSAEEQAQARAQAQAAA---EKLRKEAEQEAARRAQ 2178
Query: 219 AELQLAAEAPGPPSPMASATERLHQDLAVQE-RQSAEVQGSLALVSRALEAAERALQAQA 277
AE +A A A H+ A Q RQ A+V+ L + LE +
Sbjct: 2179 AE-----QAALRQKQAADAEMEKHKKFAEQTLRQKAQVEQELTTLRLQLEETDHQKNLLD 2233
Query: 278 QELEELNRELRQCNLQQ 294
+EL+ L E + Q+
Sbjct: 2234 EELQRLKAEATEAARQR 2250
Score = 35.8 bits (81), Expect = 0.052
Identities = 34/127 (26%), Positives = 56/127 (44%), Gaps = 4/127 (3%)
Query: 160 LRVQRNAEELGHE---AFWEQELRREQAREREGQARLQALSAATAEHAARLQALDAQARA 216
LR++ AEE+ + A E E ++E+A ERE + R +A A + Q L+ Q +
Sbjct: 1669 LRLRLQAEEVAQQKSLAQAEAEKQKEEA-EREARRRGKAEEQAVRQRELAEQELEKQRQL 1727
Query: 217 LEAELQLAAEAPGPPSPMASATERLHQDLAVQERQSAEVQGSLALVSRALEAAERALQAQ 276
E Q A + + TE+ Q + E + A +Q A ++ + E L
Sbjct: 1728 AEGTAQQRLAAEQELIRLRAETEQGEQQRQLLEEELARLQREAAAATQKRQELEAELAKV 1787
Query: 277 AQELEEL 283
E+E L
Sbjct: 1788 RAEMEVL 1794
Score = 33.1 bits (74), Expect = 0.34
Identities = 32/126 (25%), Positives = 59/126 (46%), Gaps = 9/126 (7%)
Query: 177 QELRREQAREREGQARLQALSAATAEHAARLQALD----AQARAL-EAELQLAAEAPGPP 231
Q +E+A + + A A + A+ AARL+ L AQ RAL E L+ +A
Sbjct: 2290 QRFLQEEAEKMKQVAEEAARLSVAAQEAARLRQLAEEDLAQQRALAEKMLKEKMQAVQEA 2349
Query: 232 SPMASATERLHQDLAVQERQSAEVQGSLALVSRAL----EAAERALQAQAQELEELNREL 287
+ + + E L Q + + Q+ +Q +++ L + +R L+A+ Q E++ E
Sbjct: 2350 TRLKAEAELLQQQKELAQEQARRLQEDKEQMAQQLAEETQGFQRTLEAERQRQLEMSAEA 2409
Query: 288 RQCNLQ 293
+ L+
Sbjct: 2410 ERLKLR 2415
Score = 32.3 bits (72), Expect = 0.58
Identities = 20/65 (30%), Positives = 35/65 (53%), Gaps = 2/65 (3%)
Query: 234 MASATERLHQDLAVQERQSAEVQGSLALVSRALEAAERALQAQAQELEELNRELRQCNLQ 293
++ R+ ++ + E+Q AE + LA V ALE + +A AQ + RE ++ LQ
Sbjct: 1364 ISETLRRMEEEERLAEQQRAEERERLAEVEAALEKQRQLAEAHAQAKAQAEREAKE--LQ 1421
Query: 294 QFIQQ 298
Q +Q+
Sbjct: 1422 QRMQE 1426
Score = 29.3 bits (64), Expect = 4.9
Identities = 45/183 (24%), Positives = 74/183 (40%), Gaps = 25/183 (13%)
Query: 118 AALGCEPRKTLT-PEPAPSLSRPGPAAPVTPTPGCCTDLRGLELRVQRNAEEL-----GH 171
A L E K L PEP+P+ P + + T G +R L + + G
Sbjct: 1068 ARLSAEAEKVLALPEPSPAA--PTLRSELELTLGKLEQVRSLSAIYLEKLKTISLVIRGT 1125
Query: 172 EAFWEQELRREQAREREGQA------RLQALSAATAEHAARLQALDAQARALEAELQLAA 225
+ E+ LR + + +E QA L+A A+ + A+ +A AL EL+ A
Sbjct: 1126 QGA-EEVLRAHEEQLKEAQAVPATLPELEATKASLKKLRAQAEAQQPTFDALRDELRGAQ 1184
Query: 226 EAPGPPSPMASATERLHQDLAVQERQSAEVQGSLALVSRALEAAERALQAQAQELEELNR 285
E ERL Q ++ + + +A + +A + +ELE+L R
Sbjct: 1185 EVG----------ERLQQRHGERDVEVERWRERVAQLLERWQAVLAQTDVRQRELEQLGR 1234
Query: 286 ELR 288
+LR
Sbjct: 1235 QLR 1237
Score = 28.5 bits (62), Expect = 8.3
Identities = 34/129 (26%), Positives = 58/129 (44%), Gaps = 16/129 (12%)
Query: 176 EQELRREQA-REREGQARLQALSAATAEHAA------RLQALDAQARALEAEL-----QL 223
E++L +++A E+ + ++QA+ AT A + + QAR L+ + QL
Sbjct: 2325 EEDLAQQRALAEKMLKEKMQAVQEATRLKAEAELLQQQKELAQEQARRLQEDKEQMAQQL 2384
Query: 224 AAEAPGPPSPMASATERLHQDLAVQERQSAEVQGSLALVSRALEAAERALQAQAQELEEL 283
A E G + + +R + A ER V A +SRA AE Q ++ EE+
Sbjct: 2385 AEETQGFQRTLEAERQRQLEMSAEAERLKLRV----AEMSRAQARAEEDAQRFRKQAEEI 2440
Query: 284 NRELRQCNL 292
+L + L
Sbjct: 2441 GEKLHRTEL 2449
>gi|88196790 coiled-coil domain containing 88 [Homo sapiens]
Length = 1476
Score = 42.4 bits (98), Expect = 6e-04
Identities = 40/132 (30%), Positives = 65/132 (49%), Gaps = 5/132 (3%)
Query: 158 LELRVQRNAEELGHEAFWEQELRREQAREREGQARLQALSAATAEHAARLQALDAQARAL 217
L+ ++Q +LG QEL + R +E +RLQA + Q L + L
Sbjct: 997 LQGQLQHLEGQLGSLQGRAQELLLQSQRAQEHSSRLQAEKSVLEIQG---QELHRKLEVL 1053
Query: 218 EAELQLAAEAPGPPSPMASATERLHQDLA-VQERQSAEVQGSLALVSRALEAAERALQAQ 276
E E++ A ++ A R H+ LA +Q RQ AE++G L + R L+A RAL+
Sbjct: 1054 EEEVRAARQSQEETRGQQQALLRDHKALAQLQRRQEAELEG-LLVRHRDLKANMRALELA 1112
Query: 277 AQELEELNRELR 288
+EL+ + +L+
Sbjct: 1113 HRELQGRHEQLQ 1124
Score = 38.9 bits (89), Expect = 0.006
Identities = 34/131 (25%), Positives = 56/131 (42%), Gaps = 6/131 (4%)
Query: 163 QRNAEELGHEAFWEQELRREQAREREGQARLQALSAATAEHAARLQAL----DAQARALE 218
Q+ +E WE + E G A +AL A+ + +AL +AQAR LE
Sbjct: 699 QQKSEGALEVQVWEGPIPGESLAS--GVAEQEALREEVAQLRRKAEALGDELEAQARKLE 756
Query: 219 AELQLAAEAPGPPSPMASATERLHQDLAVQERQSAEVQGSLALVSRALEAAERALQAQAQ 278
A+ AA + A H++ Q + A ++ ++ + LE+A + +A +
Sbjct: 757 AQNTEAARLSKELAQARRAEAEAHREAEAQAWEQARLREAVEAAGQELESASQEREALVE 816
Query: 279 ELEELNRELRQ 289
L RE RQ
Sbjct: 817 ALAAAGRERRQ 827
Score = 38.1 bits (87), Expect = 0.010
Identities = 44/168 (26%), Positives = 74/168 (44%), Gaps = 17/168 (10%)
Query: 156 RGLELRVQRNAEELGHEAFWEQELRREQAREREGQARLQALSAATAEHAARLQALDAQAR 215
RGLE ++R E EL RE+ + + L+ A A+L+ Q R
Sbjct: 1152 RGLEEELRRLQSEHDRAQMLLAELSRERGELQGERGELRGRLARLELERAQLEMQSQQLR 1211
Query: 216 ALEAELQLAAEAPGPPSPMASATERLHQDLAVQERQS----AEVQG----SLALVSRALE 267
+L L+A + + E L Q + QE ++ AEVQ + L+ R+LE
Sbjct: 1212 ESNQQLDLSA------CRLTTQCELLTQLRSAQEEENRQLLAEVQALSRENRELLERSLE 1265
Query: 268 AAERALQAQAQELEELN--RELRQCNLQQFIQQTGAALPPP-PRPDRG 312
+ + + Q + L++LN R +Q +++ + Q P P PR +G
Sbjct: 1266 SRDHLHREQREYLDQLNALRREKQKLVEKIMDQYRVLEPVPLPRTKKG 1313
Score = 36.2 bits (82), Expect = 0.040
Identities = 34/123 (27%), Positives = 52/123 (42%), Gaps = 7/123 (5%)
Query: 175 WEQELRREQAREREGQARLQALSAATAEHAARLQALDAQARALEAELQLAAEAPGPPSPM 234
WE+E R +A+ + R+Q L + +H + + AL+AEL+ A +
Sbjct: 828 WEREGSRLRAQSEAAEERMQVLESEGRQHLEEAERERREKEALQAELEKAVVR---GKEL 884
Query: 235 ASATERLHQDL--AVQERQS--AEVQGSLALVSRALEAAERALQAQAQELEELNRELRQC 290
+ E L ++L A ERQ E + + E LQA A EE EL+
Sbjct: 885 GARLEHLQRELEQAALERQEFLREKESQHQRYQGLEQRLEAELQAAATSKEEALMELKTR 944
Query: 291 NLQ 293
LQ
Sbjct: 945 ALQ 947
Score = 33.1 bits (74), Expect = 0.34
Identities = 30/126 (23%), Positives = 49/126 (38%), Gaps = 4/126 (3%)
Query: 177 QELRREQAREREGQARLQALSAATAEHAARLQALDAQARALE---AELQLAAEAPGPPSP 233
QEL + + QA +Q L A QAL QA+ E E + E G
Sbjct: 272 QELEEKAELLLDSQAEVQGLEAEIRRLRQEAQALSGQAKRAELYREEAEALRERAGRLPR 331
Query: 234 MASATERLHQDLAVQERQSAEVQGSLALVSRALEAAERALQAQAQELEELNRELRQCNLQ 293
+ R + L E ++++ L S LEA++ L+ Q + E L + +
Sbjct: 332 LQEELRRCRERLQAAEAYKSQLEEERVL-SGVLEASKALLEEQLEAARERCARLHETQRE 390
Query: 294 QFIQQT 299
+ +T
Sbjct: 391 NLLLRT 396
>gi|153791497 ciliary rootlet coiled-coil [Homo sapiens]
Length = 2017
Score = 41.2 bits (95), Expect = 0.001
Identities = 33/117 (28%), Positives = 55/117 (47%), Gaps = 1/117 (0%)
Query: 178 ELRREQAREREGQARLQALSAATAEHAARLQALDAQARALEAELQ-LAAEAPGPPSPMAS 236
+LR E+A ++ ++L AL+ + A+ L L AQ ++ LQ +A +
Sbjct: 726 KLRAEEASLQDSLSKLSALNESLAQDKLDLNRLVAQLEEEKSALQGRQRQAEQEATVARE 785
Query: 237 ATERLHQDLAVQERQSAEVQGSLALVSRALEAAERALQAQAQELEELNRELRQCNLQ 293
ERL + QE ++GSL + +A EA E+ L E +L +L Q + Q
Sbjct: 786 EQERLEELRLEQEVARQGLEGSLRVAEQAQEALEQQLPTLRHERSQLQEQLAQLSRQ 842
Score = 40.4 bits (93), Expect = 0.002
Identities = 37/134 (27%), Positives = 60/134 (44%), Gaps = 5/134 (3%)
Query: 178 ELRREQAREREGQARLQALSAATAEH--AARLQALDAQARALEAELQLAAEAPGPPSPMA 235
++ RE+ R E RL A A L+ +AQ + + E Q+ SP
Sbjct: 1884 KVEREKLRSHEDTVRLSAEKGRLDRTLTGAELELAEAQRQIQQLEAQVVVLEQSH-SPAQ 1942
Query: 236 SATERLHQDLAVQERQSAEVQGSLALVSRALEAAERALQAQAQELEELNRELRQCNLQQF 295
+ Q L +Q+ + ++ + A R LEA ERA + + + LEE L+ LQQ
Sbjct: 1943 LEVDAQQQQLELQQ-EVERLRSAQAQTERTLEARERAHRQRVRGLEEQVSTLKG-QLQQE 2000
Query: 296 IQQTGAALPPPPRP 309
++++ A PP P
Sbjct: 2001 LRRSSAPFSPPSGP 2014
Score = 34.3 bits (77), Expect = 0.15
Identities = 38/136 (27%), Positives = 56/136 (41%), Gaps = 3/136 (2%)
Query: 156 RGLELRVQRNAEELGHEAFWEQELRREQAREREGQARLQALSAATAEHAARLQALDAQAR 215
R L +Q+ H+ QE R + AR+ +AR Q+ S R + D + +
Sbjct: 1746 RDKNLHLQKALTACEHDRQVLQE-RLDAARQALSEARKQSSSLGEQVQTLRGEVADLELQ 1804
Query: 216 ALEAE--LQLAAEAPGPPSPMASATERLHQDLAVQERQSAEVQGSLALVSRALEAAERAL 273
+EAE LQ E +A Q L + R E GSL LEA +R +
Sbjct: 1805 RVEAEGQLQQLREVLRQRQEGEAAALNTVQKLQDERRLLQERLGSLQRALAQLEAEKREV 1864
Query: 274 QAQAQELEELNRELRQ 289
+ A LE+ LR+
Sbjct: 1865 ERSALRLEKDRVALRR 1880
Score = 32.0 bits (71), Expect = 0.75
Identities = 44/169 (26%), Positives = 65/169 (38%), Gaps = 32/169 (18%)
Query: 121 GCEPRKTLTPEPAPSLSRPGPA-APVTPTPGCCTDLRGLELRVQRNAEELGHEAFWEQEL 179
G TL P PGPA +P +P DL +R G + QEL
Sbjct: 1473 GLNSPSTLECSPGSQPPSPGPATSPASP------DLDPEAVR--------GALREFLQEL 1518
Query: 180 RREQAREREGQARLQALSAATAEHAARLQALDAQARALEAELQLAAEAPGPPSPMASATE 239
R Q E + + AL+ AE A + ++AR L+ + + EA S
Sbjct: 1519 RSAQRERDELRTQTSALNRQLAEMEAERDSATSRARQLQKAVAESEEA------RRSVDG 1572
Query: 240 RLHQDLAVQERQSAEVQGSLALVSRALEAAERALQAQAQELEELNRELR 288
RL + VQ LAL ++ +ER +A ++ L R L+
Sbjct: 1573 RL-----------SGVQAELALQEESVRRSERERRATLDQVATLERSLQ 1610
Score = 30.8 bits (68), Expect = 1.7
Identities = 39/167 (23%), Positives = 64/167 (38%), Gaps = 26/167 (15%)
Query: 129 TPEPAPSLSRPGPAAPVTPTPG-CCTDLRGLELRVQRNAEELGHEAFWEQELRREQARER 187
TP P P S PG P C+D L L H A +++L+ + R
Sbjct: 492 TPSP-PRRSSPGRGRSPRRGPSPACSDSSTLALI---------HSALHKRQLQVQDMR-- 539
Query: 188 EGQARLQALSAATAEHAARLQALDAQARALEAELQLAAEAPGPPSPMASATERLHQDLAV 247
R +A +L +++ RALE +LQ + + H+D
Sbjct: 540 ---GRYEASQDLLGTLRKQLSDSESERRALEEQLQRLRD-------KTDGAMQAHED--- 586
Query: 248 QERQSAEVQGSLALVSRALEAAERALQAQAQELEELNRELRQCNLQQ 294
+R+ ++ + L+SR +LQ Q+ EEL +E + Q
Sbjct: 587 AQREVQRLRSANELLSREKSNLAHSLQVAQQQAEELRQEREKLQAAQ 633
Score = 30.0 bits (66), Expect = 2.9
Identities = 42/152 (27%), Positives = 65/152 (42%), Gaps = 20/152 (13%)
Query: 154 DLRGLELRVQRNAEELGHEAFWEQELRREQA--REREGQARLQALSAATAEHAARLQ-AL 210
+L GL ++ E+ A ++EL ++ ERE QA L+ AA E RLQ
Sbjct: 947 ELAGLRQQIIATQEK----ASLDKELMAQKLVQAEREAQASLREQRAAHEEDLQRLQREK 1002
Query: 211 DAQARALEAE-----LQLAAEAPGPPSPMASATERLHQDLAV--QERQ------SAEVQG 257
+A R LEAE QL E + + + E L +++A QER +E Q
Sbjct: 1003 EAAWRELEAERAQLQSQLQREQEELLARLEAEKEELSEEIAALQQERDEGLLLAESEKQQ 1062
Query: 258 SLALVSRALEAAERALQAQAQELEELNRELRQ 289
+L+L A L L ++ E+ +
Sbjct: 1063 ALSLKESEKTALSEKLMGTRHSLATISLEMER 1094
Score = 29.6 bits (65), Expect = 3.7
Identities = 26/113 (23%), Positives = 45/113 (39%), Gaps = 8/113 (7%)
Query: 176 EQELRREQAREREGQARLQALSAATAEHAARLQALDAQARALEAELQLAAEAPGPPSPMA 235
E + RE R+ G+ R A A R + ++ +AE + + +
Sbjct: 1186 ESQEGREVQRQEAGELRRSLGEGAKEREALRRSNEELRSAVKKAESERIS--------LK 1237
Query: 236 SATERLHQDLAVQERQSAEVQGSLALVSRALEAAERALQAQAQELEELNRELR 288
A E Q LA+ E V + L+ ER+ +EL+EL R+++
Sbjct: 1238 LANEDKEQKLALLEEARTAVGKEAGELRTGLQEVERSRLEARRELQELRRQMK 1290
>gi|13124879 smooth muscle myosin heavy chain 11 isoform SM1A [Homo
sapiens]
Length = 1972
Score = 41.2 bits (95), Expect = 0.001
Identities = 38/129 (29%), Positives = 65/129 (50%), Gaps = 10/129 (7%)
Query: 154 DLRGLELRVQRNAEELGHEAFWEQELRREQAREREGQARLQALSAATAEHAARLQALDAQ 213
DL+ LEL Q ++ G E +Q LR+ QA+ ++ Q L+ A+ E A + + +
Sbjct: 1625 DLKDLEL--QADSAIKGREEAIKQ-LRKLQAQMKDFQRELEDARASRDEIFATAKENEKK 1681
Query: 214 ARALEAELQLAAEAPGPPSPMASATERLHQDLAVQERQSAEVQGSLALVSRALEAAERAL 273
A++LEA+L E +A ER + +++ + AE S AL+ +R L
Sbjct: 1682 AKSLEADLMQLQED-------LAAAERARKQADLEKEELAEELASSLSGRNALQDEKRRL 1734
Query: 274 QAQAQELEE 282
+A+ +LEE
Sbjct: 1735 EARIAQLEE 1743
Score = 32.3 bits (72), Expect = 0.58
Identities = 32/116 (27%), Positives = 52/116 (44%), Gaps = 6/116 (5%)
Query: 176 EQELRREQAREREGQARLQALSAATAEHAARLQAL---DAQA-RALEAELQLAAEAPGPP 231
+QELR + RE+E +AL T H A++Q + AQA L +L+ A
Sbjct: 1165 QQELRAK--REQEVTVLKKALDEETRSHEAQVQEMRQKHAQAVEELTEQLEQFKRAKANL 1222
Query: 232 SPMASATERLHQDLAVQERQSAEVQGSLALVSRALEAAERALQAQAQELEELNREL 287
E+ + DLA + R + + + + LEA + LQ++ + E EL
Sbjct: 1223 DKNKQTLEKENADLAGELRVLGQAKQEVEHKKKKLEAQVQELQSKCSDGERARAEL 1278
Score = 30.8 bits (68), Expect = 1.7
Identities = 31/142 (21%), Positives = 57/142 (40%), Gaps = 21/142 (14%)
Query: 166 AEELGHEAFWEQELRREQAREREGQARLQALSAATAEHAARLQALDAQARALEAELQLAA 225
AEE + + E R +A RE + + +L+ A E + L+ + L+AE++
Sbjct: 1458 AEEKNISSKYADERDRAEAEAREKETKALSLARALEEALEAKEELERTNKMLKAEME--- 1514
Query: 226 EAPGPPSPMASATERLHQDLAVQERQSAEVQGSLALVSRALEAAE--------------- 270
+ + L + E Q E++ L + L+A E
Sbjct: 1515 DLVSSKDDVGKNVHELEKSKRALETQMEEMKTQLEELEDELQATEDAKLRLEVNMQALKG 1574
Query: 271 ---RALQAQAQELEELNRELRQ 289
R LQA+ ++ EE R+L++
Sbjct: 1575 QFERDLQARDEQNEEKRRQLQR 1596
Score = 30.8 bits (68), Expect = 1.7
Identities = 40/150 (26%), Positives = 64/150 (42%), Gaps = 28/150 (18%)
Query: 156 RGLELRVQRNAEELG------HEAFWEQELRREQA-------REREGQAR---LQALSAA 199
R L+ R ++N E+ HE E E R+Q ++ EG + LQA SA
Sbjct: 1578 RDLQARDEQNEEKRRQLQRQLHEYETELEDERKQRALAAAAKKKLEGDLKDLELQADSAI 1637
Query: 200 TAEHAA--RLQALDAQARALEAELQLAAEAPGPPSPMASATERLHQDLAVQERQSAEVQG 257
A +L+ L AQ + + EL+ A ++ + + E+++ ++
Sbjct: 1638 KGREEAIKQLRKLQAQMKDFQRELEDAR----------ASRDEIFATAKENEKKAKSLEA 1687
Query: 258 SLALVSRALEAAERALQAQAQELEELNREL 287
L + L AAERA + E EEL EL
Sbjct: 1688 DLMQLQEDLAAAERARKQADLEKEELAEEL 1717
>gi|92091586 smooth muscle myosin heavy chain 11 isoform SM1B [Homo
sapiens]
Length = 1979
Score = 41.2 bits (95), Expect = 0.001
Identities = 38/129 (29%), Positives = 65/129 (50%), Gaps = 10/129 (7%)
Query: 154 DLRGLELRVQRNAEELGHEAFWEQELRREQAREREGQARLQALSAATAEHAARLQALDAQ 213
DL+ LEL Q ++ G E +Q LR+ QA+ ++ Q L+ A+ E A + + +
Sbjct: 1632 DLKDLEL--QADSAIKGREEAIKQ-LRKLQAQMKDFQRELEDARASRDEIFATAKENEKK 1688
Query: 214 ARALEAELQLAAEAPGPPSPMASATERLHQDLAVQERQSAEVQGSLALVSRALEAAERAL 273
A++LEA+L E +A ER + +++ + AE S AL+ +R L
Sbjct: 1689 AKSLEADLMQLQED-------LAAAERARKQADLEKEELAEELASSLSGRNALQDEKRRL 1741
Query: 274 QAQAQELEE 282
+A+ +LEE
Sbjct: 1742 EARIAQLEE 1750
Score = 32.3 bits (72), Expect = 0.58
Identities = 32/116 (27%), Positives = 52/116 (44%), Gaps = 6/116 (5%)
Query: 176 EQELRREQAREREGQARLQALSAATAEHAARLQAL---DAQA-RALEAELQLAAEAPGPP 231
+QELR + RE+E +AL T H A++Q + AQA L +L+ A
Sbjct: 1172 QQELRAK--REQEVTVLKKALDEETRSHEAQVQEMRQKHAQAVEELTEQLEQFKRAKANL 1229
Query: 232 SPMASATERLHQDLAVQERQSAEVQGSLALVSRALEAAERALQAQAQELEELNREL 287
E+ + DLA + R + + + + LEA + LQ++ + E EL
Sbjct: 1230 DKNKQTLEKENADLAGELRVLGQAKQEVEHKKKKLEAQVQELQSKCSDGERARAEL 1285
Score = 30.8 bits (68), Expect = 1.7
Identities = 31/142 (21%), Positives = 57/142 (40%), Gaps = 21/142 (14%)
Query: 166 AEELGHEAFWEQELRREQAREREGQARLQALSAATAEHAARLQALDAQARALEAELQLAA 225
AEE + + E R +A RE + + +L+ A E + L+ + L+AE++
Sbjct: 1465 AEEKNISSKYADERDRAEAEAREKETKALSLARALEEALEAKEELERTNKMLKAEME--- 1521
Query: 226 EAPGPPSPMASATERLHQDLAVQERQSAEVQGSLALVSRALEAAE--------------- 270
+ + L + E Q E++ L + L+A E
Sbjct: 1522 DLVSSKDDVGKNVHELEKSKRALETQMEEMKTQLEELEDELQATEDAKLRLEVNMQALKG 1581
Query: 271 ---RALQAQAQELEELNRELRQ 289
R LQA+ ++ EE R+L++
Sbjct: 1582 QFERDLQARDEQNEEKRRQLQR 1603
Score = 30.8 bits (68), Expect = 1.7
Identities = 40/150 (26%), Positives = 64/150 (42%), Gaps = 28/150 (18%)
Query: 156 RGLELRVQRNAEELG------HEAFWEQELRREQA-------REREGQAR---LQALSAA 199
R L+ R ++N E+ HE E E R+Q ++ EG + LQA SA
Sbjct: 1585 RDLQARDEQNEEKRRQLQRQLHEYETELEDERKQRALAAAAKKKLEGDLKDLELQADSAI 1644
Query: 200 TAEHAA--RLQALDAQARALEAELQLAAEAPGPPSPMASATERLHQDLAVQERQSAEVQG 257
A +L+ L AQ + + EL+ A ++ + + E+++ ++
Sbjct: 1645 KGREEAIKQLRKLQAQMKDFQRELEDAR----------ASRDEIFATAKENEKKAKSLEA 1694
Query: 258 SLALVSRALEAAERALQAQAQELEELNREL 287
L + L AAERA + E EEL EL
Sbjct: 1695 DLMQLQEDLAAAERARKQADLEKEELAEEL 1724
>gi|92091583 smooth muscle myosin heavy chain 11 isoform SM2B [Homo
sapiens]
Length = 1945
Score = 41.2 bits (95), Expect = 0.001
Identities = 38/129 (29%), Positives = 65/129 (50%), Gaps = 10/129 (7%)
Query: 154 DLRGLELRVQRNAEELGHEAFWEQELRREQAREREGQARLQALSAATAEHAARLQALDAQ 213
DL+ LEL Q ++ G E +Q LR+ QA+ ++ Q L+ A+ E A + + +
Sbjct: 1632 DLKDLEL--QADSAIKGREEAIKQ-LRKLQAQMKDFQRELEDARASRDEIFATAKENEKK 1688
Query: 214 ARALEAELQLAAEAPGPPSPMASATERLHQDLAVQERQSAEVQGSLALVSRALEAAERAL 273
A++LEA+L E +A ER + +++ + AE S AL+ +R L
Sbjct: 1689 AKSLEADLMQLQED-------LAAAERARKQADLEKEELAEELASSLSGRNALQDEKRRL 1741
Query: 274 QAQAQELEE 282
+A+ +LEE
Sbjct: 1742 EARIAQLEE 1750
Score = 32.3 bits (72), Expect = 0.58
Identities = 32/116 (27%), Positives = 52/116 (44%), Gaps = 6/116 (5%)
Query: 176 EQELRREQAREREGQARLQALSAATAEHAARLQAL---DAQA-RALEAELQLAAEAPGPP 231
+QELR + RE+E +AL T H A++Q + AQA L +L+ A
Sbjct: 1172 QQELRAK--REQEVTVLKKALDEETRSHEAQVQEMRQKHAQAVEELTEQLEQFKRAKANL 1229
Query: 232 SPMASATERLHQDLAVQERQSAEVQGSLALVSRALEAAERALQAQAQELEELNREL 287
E+ + DLA + R + + + + LEA + LQ++ + E EL
Sbjct: 1230 DKNKQTLEKENADLAGELRVLGQAKQEVEHKKKKLEAQVQELQSKCSDGERARAEL 1285
Score = 30.8 bits (68), Expect = 1.7
Identities = 31/142 (21%), Positives = 57/142 (40%), Gaps = 21/142 (14%)
Query: 166 AEELGHEAFWEQELRREQAREREGQARLQALSAATAEHAARLQALDAQARALEAELQLAA 225
AEE + + E R +A RE + + +L+ A E + L+ + L+AE++
Sbjct: 1465 AEEKNISSKYADERDRAEAEAREKETKALSLARALEEALEAKEELERTNKMLKAEME--- 1521
Query: 226 EAPGPPSPMASATERLHQDLAVQERQSAEVQGSLALVSRALEAAE--------------- 270
+ + L + E Q E++ L + L+A E
Sbjct: 1522 DLVSSKDDVGKNVHELEKSKRALETQMEEMKTQLEELEDELQATEDAKLRLEVNMQALKG 1581
Query: 271 ---RALQAQAQELEELNRELRQ 289
R LQA+ ++ EE R+L++
Sbjct: 1582 QFERDLQARDEQNEEKRRQLQR 1603
Score = 30.8 bits (68), Expect = 1.7
Identities = 40/150 (26%), Positives = 64/150 (42%), Gaps = 28/150 (18%)
Query: 156 RGLELRVQRNAEELG------HEAFWEQELRREQA-------REREGQAR---LQALSAA 199
R L+ R ++N E+ HE E E R+Q ++ EG + LQA SA
Sbjct: 1585 RDLQARDEQNEEKRRQLQRQLHEYETELEDERKQRALAAAAKKKLEGDLKDLELQADSAI 1644
Query: 200 TAEHAA--RLQALDAQARALEAELQLAAEAPGPPSPMASATERLHQDLAVQERQSAEVQG 257
A +L+ L AQ + + EL+ A ++ + + E+++ ++
Sbjct: 1645 KGREEAIKQLRKLQAQMKDFQRELEDAR----------ASRDEIFATAKENEKKAKSLEA 1694
Query: 258 SLALVSRALEAAERALQAQAQELEELNREL 287
L + L AAERA + E EEL EL
Sbjct: 1695 DLMQLQEDLAAAERARKQADLEKEELAEEL 1724
>gi|13124875 smooth muscle myosin heavy chain 11 isoform SM2A [Homo
sapiens]
Length = 1938
Score = 41.2 bits (95), Expect = 0.001
Identities = 38/129 (29%), Positives = 65/129 (50%), Gaps = 10/129 (7%)
Query: 154 DLRGLELRVQRNAEELGHEAFWEQELRREQAREREGQARLQALSAATAEHAARLQALDAQ 213
DL+ LEL Q ++ G E +Q LR+ QA+ ++ Q L+ A+ E A + + +
Sbjct: 1625 DLKDLEL--QADSAIKGREEAIKQ-LRKLQAQMKDFQRELEDARASRDEIFATAKENEKK 1681
Query: 214 ARALEAELQLAAEAPGPPSPMASATERLHQDLAVQERQSAEVQGSLALVSRALEAAERAL 273
A++LEA+L E +A ER + +++ + AE S AL+ +R L
Sbjct: 1682 AKSLEADLMQLQED-------LAAAERARKQADLEKEELAEELASSLSGRNALQDEKRRL 1734
Query: 274 QAQAQELEE 282
+A+ +LEE
Sbjct: 1735 EARIAQLEE 1743
Score = 32.3 bits (72), Expect = 0.58
Identities = 32/116 (27%), Positives = 52/116 (44%), Gaps = 6/116 (5%)
Query: 176 EQELRREQAREREGQARLQALSAATAEHAARLQAL---DAQA-RALEAELQLAAEAPGPP 231
+QELR + RE+E +AL T H A++Q + AQA L +L+ A
Sbjct: 1165 QQELRAK--REQEVTVLKKALDEETRSHEAQVQEMRQKHAQAVEELTEQLEQFKRAKANL 1222
Query: 232 SPMASATERLHQDLAVQERQSAEVQGSLALVSRALEAAERALQAQAQELEELNREL 287
E+ + DLA + R + + + + LEA + LQ++ + E EL
Sbjct: 1223 DKNKQTLEKENADLAGELRVLGQAKQEVEHKKKKLEAQVQELQSKCSDGERARAEL 1278
Score = 30.8 bits (68), Expect = 1.7
Identities = 31/142 (21%), Positives = 57/142 (40%), Gaps = 21/142 (14%)
Query: 166 AEELGHEAFWEQELRREQAREREGQARLQALSAATAEHAARLQALDAQARALEAELQLAA 225
AEE + + E R +A RE + + +L+ A E + L+ + L+AE++
Sbjct: 1458 AEEKNISSKYADERDRAEAEAREKETKALSLARALEEALEAKEELERTNKMLKAEME--- 1514
Query: 226 EAPGPPSPMASATERLHQDLAVQERQSAEVQGSLALVSRALEAAE--------------- 270
+ + L + E Q E++ L + L+A E
Sbjct: 1515 DLVSSKDDVGKNVHELEKSKRALETQMEEMKTQLEELEDELQATEDAKLRLEVNMQALKG 1574
Query: 271 ---RALQAQAQELEELNRELRQ 289
R LQA+ ++ EE R+L++
Sbjct: 1575 QFERDLQARDEQNEEKRRQLQR 1596
Score = 30.8 bits (68), Expect = 1.7
Identities = 40/150 (26%), Positives = 64/150 (42%), Gaps = 28/150 (18%)
Query: 156 RGLELRVQRNAEELG------HEAFWEQELRREQA-------REREGQAR---LQALSAA 199
R L+ R ++N E+ HE E E R+Q ++ EG + LQA SA
Sbjct: 1578 RDLQARDEQNEEKRRQLQRQLHEYETELEDERKQRALAAAAKKKLEGDLKDLELQADSAI 1637
Query: 200 TAEHAA--RLQALDAQARALEAELQLAAEAPGPPSPMASATERLHQDLAVQERQSAEVQG 257
A +L+ L AQ + + EL+ A ++ + + E+++ ++
Sbjct: 1638 KGREEAIKQLRKLQAQMKDFQRELEDAR----------ASRDEIFATAKENEKKAKSLEA 1687
Query: 258 SLALVSRALEAAERALQAQAQELEELNREL 287
L + L AAERA + E EEL EL
Sbjct: 1688 DLMQLQEDLAAAERARKQADLEKEELAEEL 1717
>gi|112382239 desmuslin isoform B [Homo sapiens]
Length = 1253
Score = 41.2 bits (95), Expect = 0.001
Identities = 44/152 (28%), Positives = 63/152 (41%), Gaps = 19/152 (12%)
Query: 159 ELRVQRNAEELGHEAFWEQELRREQAREREGQARLQALSAATAEHAARLQALDAQARALE 218
ELR +R G E W + R R + +L LS ATA AL + R L+
Sbjct: 42 ELRGRR-----GREGLWAEGQARCAEEARSLRQQLDELSWATALAEGERDALRRELRELQ 96
Query: 219 AELQLAAEAPGPPSPMASATERLHQDLAVQERQSAEVQGSLALVSR---ALEAAERALQ- 274
+L AE +A RL +L Q+R+ E G+ A + L+A R L
Sbjct: 97 ---RLDAEE-------RAARGRLDAELGAQQRELQEALGARAALEALLGRLQAERRGLDA 146
Query: 275 AQAQELEELNRELRQCNLQQFIQQTGAALPPP 306
A +++ EL + + TG A PPP
Sbjct: 147 AHERDVRELRARAASLTMHFRARATGPAAPPP 178
>gi|112382237 desmuslin isoform A [Homo sapiens]
Length = 1565
Score = 41.2 bits (95), Expect = 0.001
Identities = 44/152 (28%), Positives = 63/152 (41%), Gaps = 19/152 (12%)
Query: 159 ELRVQRNAEELGHEAFWEQELRREQAREREGQARLQALSAATAEHAARLQALDAQARALE 218
ELR +R G E W + R R + +L LS ATA AL + R L+
Sbjct: 42 ELRGRR-----GREGLWAEGQARCAEEARSLRQQLDELSWATALAEGERDALRRELRELQ 96
Query: 219 AELQLAAEAPGPPSPMASATERLHQDLAVQERQSAEVQGSLALVSR---ALEAAERALQ- 274
+L AE +A RL +L Q+R+ E G+ A + L+A R L
Sbjct: 97 ---RLDAEE-------RAARGRLDAELGAQQRELQEALGARAALEALLGRLQAERRGLDA 146
Query: 275 AQAQELEELNRELRQCNLQQFIQQTGAALPPP 306
A +++ EL + + TG A PPP
Sbjct: 147 AHERDVRELRARAASLTMHFRARATGPAAPPP 178
>gi|10864047 epidermal growth factor receptor pathway substrate
15-like 1 [Homo sapiens]
Length = 864
Score = 41.2 bits (95), Expect = 0.001
Identities = 41/186 (22%), Positives = 80/186 (43%), Gaps = 7/186 (3%)
Query: 114 VKPRAALGCEPRKTLTPEPAPSLSR--PGPAAPVTPTPGCCTDLRGLELRVQRNAEELGH 171
++ + + G +P + L+P+ P R PGP + + G T ++ L+ Q A+
Sbjct: 340 IQQKVSKGIDPPQVLSPDMVPPSERGTPGPDSSGSLGSGEFTGVKELDDISQEIAQLQRE 399
Query: 172 EAFWEQELRREQAREREGQARLQALSAATAEHAARLQALDAQARALEAELQLAAEAPGPP 231
+ EQ++R ++ R+ + +Q L + LQ L+AQ + + L +
Sbjct: 400 KYSLEQDIREKEEAIRQKTSEVQELQNDLDRETSSLQELEAQKQDAQDRLDEMDQQKAKL 459
Query: 232 SPMASATERLHQDLAVQERQSAEVQGSLALVSRALEAAERALQAQAQELEELNRELRQCN 291
M S + QD + + + ++ + L++ E L EL L +E +
Sbjct: 460 RDMLSDVRQKCQD---ETQMISSLKTQIQSQESDLKSQEDDLNRAKSELNRLQQE--ETQ 514
Query: 292 LQQFIQ 297
L+Q IQ
Sbjct: 515 LEQSIQ 520
>gi|78042577 MAP7 domain containing 1 [Homo sapiens]
Length = 841
Score = 41.2 bits (95), Expect = 0.001
Identities = 60/209 (28%), Positives = 81/209 (38%), Gaps = 40/209 (19%)
Query: 109 RASLPVKPRAALGCEPRKTLTPE--------------PAPSLSRPGPAAPVTPTP----G 150
R SLP PRA L L+P+ PA PGP + P P G
Sbjct: 440 RQSLPASPRARLSASTASELSPKSKARPSSPSTSWHRPASPCPSPGPGHTLPPKPPSPRG 499
Query: 151 CCTDLRGLELRVQRNAEELGHEAFWE--QELRREQAREREGQARLQ-ALSAATAEHAARL 207
+G +R + A+E A E + +R + E+E A A S A + A
Sbjct: 500 TTASPKG-RVRRKEEAKESPSAAGPEDKSQSKRRASNEKESAAPASPAPSPAPSPTPAPP 558
Query: 208 QALDAQARA-LEAELQLAAEAPGPP----SPMASATERLHQD--LAVQERQSAEVQGSLA 260
Q A +A + + AP PP PMA T+R LA + RQ+ E
Sbjct: 559 QKEQPPAETPTDAAVLTSPPAPAPPVTPSKPMAGTTDREEATRLLAEKRRQARE------ 612
Query: 261 LVSRALEAAERALQAQAQEL---EELNRE 286
R E ER LQA+ + E+L RE
Sbjct: 613 --QREREEQERRLQAERDKRMREEQLARE 639
Score = 38.9 bits (89), Expect = 0.006
Identities = 63/248 (25%), Positives = 90/248 (36%), Gaps = 34/248 (13%)
Query: 86 RTGPSLAGRPSSDSCPPPERCLIRASLPVKPRAALGCEPRKTLTP-EPAPSLSRPGPAAP 144
R G SLA P D P A++PV PR+A LTP S+ R PA
Sbjct: 338 RAGASLARGPQPDRTHPS------AAVPVCPRSASA----SPLTPCSVTRSVHRCAPAGE 387
Query: 145 V----TPTPGCCTDLRGLELRVQRNAEELGHEAFWEQELRREQAREREGQARLQALS--- 197
P G G V+R E + +++ RE +E+ AR ++L
Sbjct: 388 RGERRKPNAG------GSPAPVRRRPEASPVQKKEKKDKERENEKEKSALARERSLKKRQ 441
Query: 198 AATAEHAARLQA-----LDAQARALEAELQLAAEAPGPPSPMASATERLHQDLAVQERQS 252
+ A ARL A L +++A + + P P P L +
Sbjct: 442 SLPASPRARLSASTASELSPKSKARPSSPSTSWHRPASPCPSPGPGHTLPPKPPSPRGTT 501
Query: 253 AEVQGSLALVSRALEAAERALQAQAQELEELNRELRQCNLQQFIQQTGAALPPPPRPDRG 312
A +G V R EA E A ++ + R R N ++ A P P P
Sbjct: 502 ASPKGR---VRRKEEAKESPSAAGPEDKSQSKR--RASNEKESAAPASPAPSPAPSPTPA 556
Query: 313 PPGTQWPP 320
PP + PP
Sbjct: 557 PPQKEQPP 564
Score = 36.2 bits (82), Expect = 0.040
Identities = 45/176 (25%), Positives = 66/176 (37%), Gaps = 29/176 (16%)
Query: 124 PRKTLTPEPAPS-----LSRPGPAAPVTPTPGCCTDLRGLELRVQRNAEELGHEAFWEQE 178
P+K P P+ S P PA PVTP+ + + EE ++
Sbjct: 558 PQKEQPPAETPTDAAVLTSPPAPAPPVTPSK---------PMAGTTDREEATRLLAEKRR 608
Query: 179 LRREQAREREGQARLQALSAATAEHAARLQALDAQARALEAELQLAAEAPGPPSPMASAT 238
REQ E + RLQA R + + + A EAE + EA A
Sbjct: 609 QAREQREREEQERRLQA---------ERDKRMREEQLAREAEARAEREAEARRREEQEAR 659
Query: 239 ERLHQDLAVQER-----QSAEVQGSLALVSRALEAAERALQAQAQELEELNRELRQ 289
E+ + QER + AE + + LE E+ Q Q QE +E + L +
Sbjct: 660 EKAQAEQEEQERLQKQKEEAEARSREEAERQRLE-REKHFQQQEQERQERRKRLEE 714
Score = 30.4 bits (67), Expect = 2.2
Identities = 50/225 (22%), Positives = 83/225 (36%), Gaps = 19/225 (8%)
Query: 83 VLRRTGPSLAGRPSSDSCPPPE--RCLIRASLPVKPRAALGCEPRKTLTPEPAPSLSR-- 138
V+ RT P P D PPP L+ + P P A K L EP +
Sbjct: 17 VVARTPPEPRPSPEGDPSPPPPPMSALVPDTPPDTPPAMKNATSSKQLPLEPESPSGQVG 76
Query: 139 PGPAAPVTPTPGCCTDLRGLELRVQRNAEELGHEAFWEQELRREQAREREGQARLQALSA 198
P PA P +P RG +G R + R Q A+ A
Sbjct: 77 PRPAPPQEESPSSEAKSRG------PTPPAMGP--------RDARPPRRSSQPSPTAVPA 122
Query: 199 ATAEHAARLQALDAQARALEAELQLAAEAPGPPSPMASATERLHQDLAVQERQSAEVQGS 258
+ + + + A R A+ + A + A E+ + A++E+Q E +
Sbjct: 123 SDSP-PTKQEVKKAGERHKLAKERREERAKYLAAKKAVWLEKEEKAKALREKQLQERRRR 181
Query: 259 LALVSRALEAAERALQAQAQELEELNRELRQCNLQQFIQQTGAAL 303
L E AL+ + ++ E N+E + +Q+ +++T A +
Sbjct: 182 LEEQRLKAEQRRAALEERQRQKLEKNKERYEAAIQRSVKKTWAEI 226
>gi|41406064 myosin, heavy polypeptide 10, non-muscle [Homo sapiens]
Length = 1976
Score = 40.8 bits (94), Expect = 0.002
Identities = 38/144 (26%), Positives = 67/144 (46%), Gaps = 7/144 (4%)
Query: 154 DLRGLELRVQRNAEELGHEAFWEQELRREQAREREGQARLQALSAATAEHAARLQALDAQ 213
DL+ LE +++ A + E ++LR+ QA+ ++ Q L+ A+ E A+ + + +
Sbjct: 1625 DLKDLEAQIEA-ANKARDEVI--KQLRKLQAQMKDYQRELEEARASRDEIFAQSKESEKK 1681
Query: 214 ARALEAELQLAAEAPGPPSPMASATERLHQDLAVQERQSAEVQGSLALVSRALEA----A 269
++LEAE+ E E+ +LA + SA + +L R LEA
Sbjct: 1682 LKSLEAEILQLQEELASSERARRHAEQERDELADEITNSASGKSALLDEKRRLEARIAQL 1741
Query: 270 ERALQAQAQELEELNRELRQCNLQ 293
E L+ + +E LN R+ LQ
Sbjct: 1742 EEELEEEQSNMELLNDRFRKTTLQ 1765
Score = 35.4 bits (80), Expect = 0.068
Identities = 31/123 (25%), Positives = 62/123 (50%), Gaps = 10/123 (8%)
Query: 160 LRVQRNAEELGHEAFWEQELRREQAREREGQARLQALSAATAEHAARLQALDAQARALEA 219
L+V R EEL + ++EL + + ++ + + L+ + +H L+ + A L+A
Sbjct: 845 LQVTRQEEELQAK---DEELLKVKEKQTKVEGELEEMER---KHQQLLEEKNILAEQLQA 898
Query: 220 ELQLAAEAPGPPSPMASATERLHQDLAVQERQSAEVQGSLALVSRALEAAERALQAQAQE 279
E +L AEA + +A+ + L + L E + E + ++ L+ ++ +QA Q+
Sbjct: 899 ETELFAEAEEMRARLAAKKQELEEILHDLESRVEEEEER----NQILQNEKKKMQAHIQD 954
Query: 280 LEE 282
LEE
Sbjct: 955 LEE 957
Score = 33.1 bits (74), Expect = 0.34
Identities = 31/118 (26%), Positives = 55/118 (46%), Gaps = 8/118 (6%)
Query: 176 EQELRREQAREREGQARLQALSAATAEHAARLQALDAQARALEAELQLAAEAPGPPSPMA 235
E+ L++E+ +E + + L T + ++ L AQ E +LQLA + +A
Sbjct: 1040 EERLKKEEKTRQELEKAKRKLDGETTDLQDQIAELQAQID--ELKLQLAKKEEELQGALA 1097
Query: 236 SAT-ERLHQDLAVQ-----ERQSAEVQGSLALVSRALEAAERALQAQAQELEELNREL 287
E LH++ A++ + Q AE+Q + AE+ + ++ELE L EL
Sbjct: 1098 RGDDETLHKNNALKVVRELQAQIAELQEDFESEKASRNKAEKQKRDLSEELEALKTEL 1155
>gi|114842389 myosin, heavy polypeptide 7B, cardiac muscle, beta [Homo
sapiens]
Length = 1983
Score = 40.4 bits (93), Expect = 0.002
Identities = 58/217 (26%), Positives = 86/217 (39%), Gaps = 8/217 (3%)
Query: 78 SDVQFVLRRTGPSLAGRPSSDSCPPPERCLIRASLPVKPRAALGCEPRKTLTPEPAPSLS 137
SD+ + +G S+ + E+ I+A+L + AL E KTL + S
Sbjct: 1559 SDLTDQVSLSGKSIQELEKTKKALEGEKSEIQAALE-EAEGALELEETKTLRIQLELSQV 1617
Query: 138 RPGPAAPVTPTPGCCTDLRGLELRVQRNAEELGHEAFWEQELRREQAR-EREGQARLQAL 196
+ + C +LR QR E L E R E R +++ + L L
Sbjct: 1618 KAEVDRKLAEKDEECANLRRNH---QRAVESLQASLDAETRARNEALRLKKKMEGDLNDL 1674
Query: 197 SAATAEHAARLQALDAQARALEAELQLAAEAPGPPSPMASATERLHQDLAVQERQSAEVQ 256
HA R QA +AQA + QL E G A E LH+ ER+++ +
Sbjct: 1675 ELQLG-HATR-QATEAQAATRLMQAQLKEEQAGRDEEQRLAAE-LHEQAQALERRASLLA 1731
Query: 257 GSLALVSRALEAAERALQAQAQELEELNRELRQCNLQ 293
L + ALE ER+ + QEL E L + Q
Sbjct: 1732 AELEELRAALEQGERSRRLAEQELLEATERLNLLHSQ 1768
Score = 34.7 bits (78), Expect = 0.12
Identities = 34/125 (27%), Positives = 51/125 (40%), Gaps = 16/125 (12%)
Query: 179 LRREQAREREGQARLQAL-SAATAEHAA-----------RLQALDAQARALEAELQLAAE 226
LR + E E QA LQ L S A AE A R + L+ + L LQ A E
Sbjct: 1392 LREQHEEEAEAQAELQRLLSKANAEVAQWRSKYEADAIQRTEELEEAKKKLALRLQEAEE 1451
Query: 227 APGPPSPMASATERLHQDLAVQER----QSAEVQGSLALVSRALEAAERALQAQAQELEE 282
+ S+ E+ L + + + A + + ERAL+ + ++ EE
Sbjct: 1452 GVEAANAKCSSLEKAKLRLQTESEDVTLELERATSAAAALDKKQRHLERALEERRRQEEE 1511
Query: 283 LNREL 287
+ REL
Sbjct: 1512 MQREL 1516
Score = 32.7 bits (73), Expect = 0.44
Identities = 43/155 (27%), Positives = 65/155 (41%), Gaps = 25/155 (16%)
Query: 154 DLRGLELRVQRNAEELGHEAFWEQELRREQAREREGQARLQALSAATAEHAARLQALDAQ 213
DL LEL++ + + ++ + E+ G+ Q L+A E A QAL+ +
Sbjct: 1670 DLNDLELQLGHATRQATEAQAATRLMQAQLKEEQAGRDEEQRLAAELHEQA---QALERR 1726
Query: 214 ARALEAELQ--LAAEAPGPPS------PMASATERL---HQDLAVQERQSAEVQGSLALV 262
A L AEL+ AA G S + ATERL H Q +++ LA +
Sbjct: 1727 ASLLAAELEELRAALEQGERSRRLAEQELLEATERLNLLHSQNTGLLNQKKKLEADLAQL 1786
Query: 263 S-----------RALEAAERALQAQAQELEELNRE 286
S A E A++A+ A EEL +E
Sbjct: 1787 SGEVEEAAQERREAEEKAKKAITDAAMMAEELKKE 1821
Score = 30.4 bits (67), Expect = 2.2
Identities = 36/139 (25%), Positives = 53/139 (38%), Gaps = 16/139 (11%)
Query: 158 LELRVQRNAEELGHEAFWEQELRREQAREREGQARLQALSAATAEHAARLQALDAQARAL 217
L + A ELG + Q +R++ +E+ L + AA ++ L RA
Sbjct: 1241 LRRKQAEGAAELGEQVDSLQRVRQKLEKEKS------ELRMEVDDLAANVETL---TRAK 1291
Query: 218 EAELQLAAEAPGPPSPMASATERLHQDLAVQERQSAEVQGSLALVSRALEAAE------- 270
+ +L S E L + LA Q +Q +SR LE E
Sbjct: 1292 ASAEKLCRTYEDQLSEAKIKVEELQRQLADASTQRGRLQTESGELSRLLEEKECLISQLS 1351
Query: 271 RALQAQAQELEELNRELRQ 289
R AQ LEEL R+L +
Sbjct: 1352 RGKALAAQSLEELRRQLEE 1370
Score = 30.0 bits (66), Expect = 2.9
Identities = 26/113 (23%), Positives = 48/113 (42%), Gaps = 1/113 (0%)
Query: 176 EQELRRE-QAREREGQARLQALSAATAEHAARLQALDAQARALEAELQLAAEAPGPPSPM 234
E+E++RE +A +RE + L H L+AL+ R + + ++ S
Sbjct: 1509 EEEMQRELEAAQRESRGLGTELFRLRHGHEEALEALETLKRENKNLQEEISDLTDQVSLS 1568
Query: 235 ASATERLHQDLAVQERQSAEVQGSLALVSRALEAAERALQAQAQELEELNREL 287
+ + L + E + +E+Q +L ALE E EL ++ E+
Sbjct: 1569 GKSIQELEKTKKALEGEKSEIQAALEEAEGALELEETKTLRIQLELSQVKAEV 1621
>gi|14249342 internexin neuronal intermediate filament protein,
alpha [Homo sapiens]
Length = 499
Score = 40.0 bits (92), Expect = 0.003
Identities = 35/132 (26%), Positives = 57/132 (43%), Gaps = 21/132 (15%)
Query: 168 ELGHEAFWEQELRREQAREREGQARLQALSAATAEHAARLQALDAQARALEAELQLAAEA 227
+L A E + + E+E +LQ L+ A ++ L+ Q RALEAEL +
Sbjct: 76 DLSQAAARTNEYKIIRTNEKE---QLQGLNDRFAVFIEKVHQLETQNRALEAELAALRQR 132
Query: 228 PGPPSPMASATERLHQDLAVQERQSAEVQGSLAL------------------VSRALEAA 269
PS + +R +DL Q +++ + L SR E A
Sbjct: 133 HAEPSRVGELFQRELRDLRAQLEEASSARSQALLERDGLAEEVQRLRARCEEESRGREGA 192
Query: 270 ERALQAQAQELE 281
ERAL+AQ ++++
Sbjct: 193 ERALKAQQRDVD 204
Database: hs.faa
Posted date: Aug 4, 2009 4:42 PM
Number of letters in database: 18,247,518
Number of sequences in database: 37,866
Lambda K H
0.316 0.130 0.386
Gapped
Lambda K H
0.267 0.0410 0.140
Matrix: BLOSUM62
Gap Penalties: Existence: 11, Extension: 1
Number of Hits to DB: 14,724,344
Number of Sequences: 37866
Number of extensions: 812817
Number of successful extensions: 10436
Number of sequences better than 10.0: 30
Number of HSP's better than 10.0 without gapping: 141
Number of HSP's successfully gapped in prelim test: 542
Number of HSP's that attempted gapping in prelim test: 8609
Number of HSP's gapped (non-prelim): 2201
length of query: 320
length of database: 18,247,518
effective HSP length: 102
effective length of query: 218
effective length of database: 14,385,186
effective search space: 3135970548
effective search space used: 3135970548
T: 11
A: 40
X1: 16 ( 7.3 bits)
X2: 38 (14.6 bits)
X3: 64 (24.7 bits)
S1: 41 (21.6 bits)
S2: 62 (28.5 bits)
Search results were obtained with NCBI BLAST and RefSeq entries.
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Guide to the Human Genome
Copyright © 2010 by Stewart Scherer. All rights reserved.