Home |
Table of Contents |
Search text |
Search genes |
Search sequences |
Purchase |
FAQ |
Blog |
Help
Search of human proteins with 114842410
BLASTP 2.2.11 [Jun-05-2005]
Reference: Altschul, Stephen F., Thomas L. Madden, Alejandro A. Schaffer,
Jinghui Zhang, Zheng Zhang, Webb Miller, and David J. Lipman (1997),
"Gapped BLAST and PSI-BLAST: a new generation of protein database search
programs", Nucleic Acids Res. 25:3389-3402.
Query= gi|114842410 zinc finger CCCH-type containing 11A [Homo
sapiens]
(810 letters)
Database: hs.faa
37,866 sequences; 18,247,518 total letters
Searching..................................................done
Score E
Sequences producing significant alignments: (bits) Value
gi|114842410 zinc finger CCCH-type containing 11A [Homo sapiens] 1592 0.0
gi|22749213 hypothetical protein LOC160419 [Homo sapiens] 70 1e-11
gi|104526627 triadin [Homo sapiens] 62 3e-09
gi|32483416 neurofilament, heavy polypeptide 200kDa [Homo sapiens] 61 5e-09
gi|52426735 ankyrin 2 isoform 1 [Homo sapiens] 54 8e-07
gi|41281453 serine/threonine kinase 2 [Homo sapiens] 50 8e-06
gi|71361682 nuclear mitotic apparatus protein 1 [Homo sapiens] 49 2e-05
gi|84043963 eukaryotic translation initiation factor 5B [Homo sa... 49 2e-05
gi|38045898 RAB6-interacting protein 2 isoform epsilon [Homo sap... 49 2e-05
gi|38045896 RAB6-interacting protein 2 isoform delta [Homo sapiens] 49 2e-05
gi|41322923 plectin 1 isoform 11 [Homo sapiens] 48 3e-05
gi|41322914 plectin 1 isoform 10 [Homo sapiens] 48 3e-05
gi|41322919 plectin 1 isoform 8 [Homo sapiens] 48 3e-05
gi|41322910 plectin 1 isoform 7 [Homo sapiens] 48 3e-05
gi|41322916 plectin 1 isoform 6 [Homo sapiens] 48 3e-05
gi|41322908 plectin 1 isoform 3 [Homo sapiens] 48 3e-05
gi|41322912 plectin 1 isoform 2 [Homo sapiens] 48 3e-05
gi|47607492 plectin 1 isoform 1 [Homo sapiens] 48 3e-05
gi|153945790 myosin, heavy chain 8, skeletal muscle, perinatal [... 48 4e-05
gi|44680105 caldesmon 1 isoform 1 [Homo sapiens] 47 5e-05
gi|89276756 serine/threonine-protein kinase PRP4K [Homo sapiens] 47 5e-05
gi|5174573 myeloid/lymphoid or mixed-lineage leukemia trithorax ... 47 7e-05
gi|87299628 biorientation of chromosomes in cell division 1-like... 47 7e-05
gi|125987603 cleavage and polyadenylation specific factor 4, 30k... 47 7e-05
gi|5729939 cleavage and polyadenylation specific factor 4, 30kDa... 47 7e-05
gi|14790190 spen homolog, transcriptional regulator [Homo sapiens] 47 9e-05
gi|207113162 Treacher Collins-Franceschetti syndrome 1 isoform e... 47 9e-05
gi|207113160 Treacher Collins-Franceschetti syndrome 1 isoform d... 47 9e-05
gi|57164977 Treacher Collins-Franceschetti syndrome 1 isoform a ... 47 9e-05
gi|57164979 Treacher Collins-Franceschetti syndrome 1 isoform c ... 47 9e-05
>gi|114842410 zinc finger CCCH-type containing 11A [Homo sapiens]
Length = 810
Score = 1592 bits (4121), Expect = 0.0
Identities = 810/810 (100%), Positives = 810/810 (100%)
Query: 1 MPNQGEDCYFFFYSTCTKGDSCPFRHCEAAIGNETVCTLWQEGRCFRQVCRFRHMEIDKK 60
MPNQGEDCYFFFYSTCTKGDSCPFRHCEAAIGNETVCTLWQEGRCFRQVCRFRHMEIDKK
Sbjct: 1 MPNQGEDCYFFFYSTCTKGDSCPFRHCEAAIGNETVCTLWQEGRCFRQVCRFRHMEIDKK 60
Query: 61 RSEIPCYWENQPTGCQKLNCAFHHNRGRYVDGLFLPPSKTVLPTVPESPEEEVKASQLSV 120
RSEIPCYWENQPTGCQKLNCAFHHNRGRYVDGLFLPPSKTVLPTVPESPEEEVKASQLSV
Sbjct: 61 RSEIPCYWENQPTGCQKLNCAFHHNRGRYVDGLFLPPSKTVLPTVPESPEEEVKASQLSV 120
Query: 121 QQNKLSVQSNPSPQLRSVMKVESSENVPSPTHPPVVINAADDDEDDDDQFSEEGDETKTP 180
QQNKLSVQSNPSPQLRSVMKVESSENVPSPTHPPVVINAADDDEDDDDQFSEEGDETKTP
Sbjct: 121 QQNKLSVQSNPSPQLRSVMKVESSENVPSPTHPPVVINAADDDEDDDDQFSEEGDETKTP 180
Query: 181 TLQPTPEVHNGLRVTSVRKPAVNIKQGECLNFGIKTLEEIKSKKMKEKSKKQGEGSSGVS 240
TLQPTPEVHNGLRVTSVRKPAVNIKQGECLNFGIKTLEEIKSKKMKEKSKKQGEGSSGVS
Sbjct: 181 TLQPTPEVHNGLRVTSVRKPAVNIKQGECLNFGIKTLEEIKSKKMKEKSKKQGEGSSGVS 240
Query: 241 SLLLHPEPVPGPEKENVRTVVRTVTLSTKQGEEPLVRLSLTERLGKRKFSAGGDSDPPLK 300
SLLLHPEPVPGPEKENVRTVVRTVTLSTKQGEEPLVRLSLTERLGKRKFSAGGDSDPPLK
Sbjct: 241 SLLLHPEPVPGPEKENVRTVVRTVTLSTKQGEEPLVRLSLTERLGKRKFSAGGDSDPPLK 300
Query: 301 RSLAQRLGKKVEAPETNIDKTPKKAQVSKSLKERLGMSADPDNEDATDKVNKVGEIHVKT 360
RSLAQRLGKKVEAPETNIDKTPKKAQVSKSLKERLGMSADPDNEDATDKVNKVGEIHVKT
Sbjct: 301 RSLAQRLGKKVEAPETNIDKTPKKAQVSKSLKERLGMSADPDNEDATDKVNKVGEIHVKT 360
Query: 361 LEEILLERASQKRGELQTKLKTEGPSKTDDSTSGARSSSTIRIKTFSEVLAEKKHRQQEA 420
LEEILLERASQKRGELQTKLKTEGPSKTDDSTSGARSSSTIRIKTFSEVLAEKKHRQQEA
Sbjct: 361 LEEILLERASQKRGELQTKLKTEGPSKTDDSTSGARSSSTIRIKTFSEVLAEKKHRQQEA 420
Query: 421 ERQKSKKDTTCIKLKIDSEIKKTVVLPPIVASRGQSEEPAGKTKSMQEVHIKTLEEIKLE 480
ERQKSKKDTTCIKLKIDSEIKKTVVLPPIVASRGQSEEPAGKTKSMQEVHIKTLEEIKLE
Sbjct: 421 ERQKSKKDTTCIKLKIDSEIKKTVVLPPIVASRGQSEEPAGKTKSMQEVHIKTLEEIKLE 480
Query: 481 KALRVQQSSESSTSSPSQHEATPGARRLLRITKRTGMKEEKNLQEGNEVDSQSSIRTEAK 540
KALRVQQSSESSTSSPSQHEATPGARRLLRITKRTGMKEEKNLQEGNEVDSQSSIRTEAK
Sbjct: 481 KALRVQQSSESSTSSPSQHEATPGARRLLRITKRTGMKEEKNLQEGNEVDSQSSIRTEAK 540
Query: 541 EASGETTGVDITKIQVKRCETMREKHMQKQQEREKSVLTPLRGDVASCNTQVAEKPVLTA 600
EASGETTGVDITKIQVKRCETMREKHMQKQQEREKSVLTPLRGDVASCNTQVAEKPVLTA
Sbjct: 541 EASGETTGVDITKIQVKRCETMREKHMQKQQEREKSVLTPLRGDVASCNTQVAEKPVLTA 600
Query: 601 VPGITRHLTKRLPTKSSQKVEVETSGIGDSLLNVKCAAQTLEKRGKAKPKVNVKPSVVKV 660
VPGITRHLTKRLPTKSSQKVEVETSGIGDSLLNVKCAAQTLEKRGKAKPKVNVKPSVVKV
Sbjct: 601 VPGITRHLTKRLPTKSSQKVEVETSGIGDSLLNVKCAAQTLEKRGKAKPKVNVKPSVVKV 660
Query: 661 VSSPKLAPKRKAVEMHAAVIAAVKPLSSSSVLQEPPAKKAAVAVVPLVSEDKSVTVPEAE 720
VSSPKLAPKRKAVEMHAAVIAAVKPLSSSSVLQEPPAKKAAVAVVPLVSEDKSVTVPEAE
Sbjct: 661 VSSPKLAPKRKAVEMHAAVIAAVKPLSSSSVLQEPPAKKAAVAVVPLVSEDKSVTVPEAE 720
Query: 721 NPRDSLVLPPTQSSSDSSPPEVSGPSSSQMSMKTRRLSSASTGKPPLSVEDDFEKLIWEI 780
NPRDSLVLPPTQSSSDSSPPEVSGPSSSQMSMKTRRLSSASTGKPPLSVEDDFEKLIWEI
Sbjct: 721 NPRDSLVLPPTQSSSDSSPPEVSGPSSSQMSMKTRRLSSASTGKPPLSVEDDFEKLIWEI 780
Query: 781 SGGKLEAEIDLDPGKDEDDLLLELSEMIDS 810
SGGKLEAEIDLDPGKDEDDLLLELSEMIDS
Sbjct: 781 SGGKLEAEIDLDPGKDEDDLLLELSEMIDS 810
>gi|22749213 hypothetical protein LOC160419 [Homo sapiens]
Length = 414
Score = 69.7 bits (169), Expect = 1e-11
Identities = 38/123 (30%), Positives = 64/123 (52%), Gaps = 21/123 (17%)
Query: 59 KKRSEIPCYWENQPTGCQKLNCAFHHNRGRYVDGLFLPPSKTVLPTVPESPEEEVKASQL 118
++ I C+WE QP GC K++C F+H++ R ++GLFLPPS S +
Sbjct: 4 QQNCSISCFWETQPLGCVKISCIFYHSKPRNINGLFLPPS-----------------SNI 46
Query: 119 SVQQNKLSVQSNPSPQLRSVMKVESSENVPSPTHPPVVINA-ADDDEDDDDQFSEEGDET 177
++Q+ +Q Q +S ++ EN+ P H P+V+ +++E+ D+Q T
Sbjct: 47 TLQK---EIQEGIPLQSQSQEPLKPQENISRPIHHPLVLKTNFEEEEEVDEQNDASSLWT 103
Query: 178 KTP 180
KTP
Sbjct: 104 KTP 106
>gi|104526627 triadin [Homo sapiens]
Length = 729
Score = 61.6 bits (148), Expect = 3e-09
Identities = 129/606 (21%), Positives = 232/606 (38%), Gaps = 108/606 (17%)
Query: 156 VINAADDDEDDDDQFSEEGDETKTPTLQPTPEVHNGLRVTSVRKPAVNIKQGECLNFGIK 215
+I++ D+++DD D+ +++G+ + P + E+H + KP +
Sbjct: 113 IISSEDEEDDDGDEDTDKGEIDEPPLRKK--EIHKD-KTEKQEKPE-------------R 156
Query: 216 TLEEIKSKKMKEKSKKQGEGSSGVSSLLLHPEPVPGPEKENVRTVVRTVTLSTKQGEEPL 275
++ + K KEK K++ H E + EK +T+ + K E+
Sbjct: 157 KIQTKVTHKEKEKGKEKVREKEKPEKKATHKEKIEKKEKPETKTLAKEQK-KAKTAEK-- 213
Query: 276 VRLSLTERLGKRKFSAGGDSDPPLKRSLAQRLGKKVEAPETNIDKTPKKAQVSKSLKERL 335
+E K++ G Q K+ A + KTP K + K KE+
Sbjct: 214 -----SEEKTKKEVKGG-----------KQEKVKQTAAKVKEVQKTPSKPK-EKEDKEKA 256
Query: 336 GMSADPDNEDATDKVNKVGEIHVKTLEEILLERASQKRGE---LQTKLKTEGPSKTDDST 392
+S + +D + +I V K G+ + L TE S+ ++
Sbjct: 257 AVSKH-EQKDQYAFCRYMIDIFV---------HGDLKPGQSPAIPPPLPTEQASRPTPAS 306
Query: 393 SGARSSSTIRIKTFSEVLAEKKHRQQEAERQKSKKDTTCIKLKID----SEIKKTVV--L 446
+ K +V +E K +++E ++KS+K+T K + SE K+ V
Sbjct: 307 PALEEKEGEKKKAEKKVTSETKKKEKEDIKKKSEKETAIDVEKKEPGKASETKQGTVKIA 366
Query: 447 PPIVASRGQSEEPAGKTKSMQEVHI-KTLEEIKLEKALRVQQSSESSTSSPSQHEATPGA 505
A + + +E + KTK EV K ++ K EK + +S + S PS +
Sbjct: 367 AQAAAKKDEKKEDSKKTKKPAEVEQPKGKKQEKKEKHVEPAKSPKKEHSVPSDKQVKAKT 426
Query: 506 RRL------LRITKRT-GMKEEKNLQ------EGNEVDSQSSIRTEAKEASGETTGVDIT 552
R + I K G KEEK + + SSI + + G+ V +
Sbjct: 427 ERAKEEIGAVSIKKAVPGKKEEKTTKTVEQEIRKEKSGKTSSILKDKEPIKGKEEKVPAS 486
Query: 553 KIQVKRCETMREKHMQKQQEREKSVLTPLRG---------------------------DV 585
++ K ET +++ M K + K L+G D+
Sbjct: 487 -LKEKEPETKKDEKMSKAGKEVKPKPPQLQGKKEEKPEPQIKKEAKPAISEKVQIHKQDI 545
Query: 586 ASCNTQVA----EKPVLTAVPGITRHLT-KRLPTKSSQKVEVETSGIG-DSLLNVKCAAQ 639
V+ E+ VL V +T T K PTK ++ E E I D
Sbjct: 546 VKPEKTVSHGKPEEKVLKQVKAVTIEKTAKPKPTKKAEHREREPPSIKTDKPKPTPKGTS 605
Query: 640 TLEKRGKAKPKVNVKPSVVKV----VSSPKLAPKRKAVEMHAAVIAAVKPLSSSSVLQEP 695
+ + GK K +++ K S K + K++ +++++++H V A KP S +++
Sbjct: 606 EVTESGKKKTEISEKESKEKADMKHLREEKVSTRKESLQLH-NVTKAEKPARVSKDVEDV 664
Query: 696 PAKKAA 701
PA K A
Sbjct: 665 PASKKA 670
>gi|32483416 neurofilament, heavy polypeptide 200kDa [Homo sapiens]
Length = 1020
Score = 60.8 bits (146), Expect = 5e-09
Identities = 104/488 (21%), Positives = 187/488 (38%), Gaps = 54/488 (11%)
Query: 108 SPEEEVKASQLSVQQNKLSVQSNPSPQLRSVMKVESSENVPSPTHPPVVINAADDDEDDD 167
SPE+E K+ ++ +S + +S +V+S E SP A ++ +
Sbjct: 511 SPEKEAKSPVKEEAKSPAEAKSPEKEEAKSPAEVKSPEKAKSP--------AKEEAKSPP 562
Query: 168 DQFSEEGDETKTPTLQPTPEVHNGLRVTSVRKPAVNIKQGECLNFGIKTLEEIKSKKMKE 227
+ S E +E K+P +PE + PA K+ E+ KS +KE
Sbjct: 563 EAKSPEKEEAKSPAEVKSPEKAKSPAKEEAKSPA-----------EAKSPEKAKS-PVKE 610
Query: 228 KSKKQGEGSSGVSSLLLHPEPVPGPEK------------ENVRTVVRTVTLSTKQGEEPL 275
++K E S V P V PEK E ++ + S ++ + P+
Sbjct: 611 EAKSPAEAKSPVKEEAKSPAEVKSPEKAKSPTKEEAKSPEKAKSPEKEEAKSPEKAKSPV 670
Query: 276 VRLSLTERLGKRKFSAGGDSDPPLKRSLAQ--RLGKKVEAPETNIDKTPKKAQVSKSLKE 333
+ + K A S K + + + +K ++P K+P+KA+ +
Sbjct: 671 KAEAKSPEKAKSPVKAEAKSPEKAKSPVKEEAKSPEKAKSPVKEEAKSPEKAKSPVKEEA 730
Query: 334 RLGMSA-DPDNEDATDKVNKVGEIHVKTLEEILLERASQKRGELQTKLKTEGPSKTDDST 392
+ A P E+A KTL+ K E +T K E S D
Sbjct: 731 KTPEKAKSPVKEEAKSPEKAKSPEKAKTLD--------VKSPEAKTPAKEEARSPADKFP 782
Query: 393 SGARSSSTIRIKTFSEVLAEKKHRQQEAERQKSKKDTTCIKLKIDSEIKKTVVLPPIVAS 452
A+S +K+ + + K + E++ KK+ +K + + ++ V P
Sbjct: 783 EKAKSPVKEEVKSPEKAKSPLKEDAKAPEKEIPKKEEVKSPVKEEEKPQEVKVKEP---P 839
Query: 453 RGQSEEPAGKTKSMQEVHIKTLEEIKLEKA--LRVQQSSESSTSSPSQHEATPGARRLLR 510
+ EE A T +E EE ++A +V++ E + P E+ A++
Sbjct: 840 KKAEEEKAPATPKTEEKKDSKKEEAPKKEAPKPKVEEKKEPAVEKPK--ESKVEAKKEEA 897
Query: 511 ITKRTGMKEEKNLQEGNEV--DSQSSIRTE-AKEASGETTGVDITKIQVKRCETMREKHM 567
K+ EK EV D++ +TE AK+ + + +K K+ E EK
Sbjct: 898 EDKKKVPTPEKEAPAKVEVKEDAKPKEKTEVAKKEPDDAKAKEPSKPAEKK-EAAPEKKD 956
Query: 568 QKQQEREK 575
K+++ +K
Sbjct: 957 TKEEKAKK 964
Score = 59.7 bits (143), Expect = 1e-08
Identities = 118/565 (20%), Positives = 202/565 (35%), Gaps = 59/565 (10%)
Query: 218 EEIKSKKMKEKSKKQGEGSSGVSSLLLHPEPVPGPEKENVRTVVRTVTLSTKQGEEPLVR 277
EE KS +E + + E S V P PEKE + S + + P
Sbjct: 499 EETKSPPAEEAASPEKEAKSPVKEEAKSPAEAKSPEKEEAK--------SPAEVKSPEKA 550
Query: 278 LSLTERLGKRKFSAGGDSDPPLKRSLAQRLGKKVEAPETNIDKTPKKAQVSKSLKERLGM 337
S + K A K + +K ++P K+P +A+ + K +
Sbjct: 551 KSPAKEEAKSPPEAKSPEKEEAKSPAEVKSPEKAKSPAKEEAKSPAEAKSPEKAKSPVKE 610
Query: 338 SA-DPDNEDATDKVNKVGEIHVKTLEEILLERASQKRGELQTKLKTEGPSKTDDSTSGAR 396
A P + K VK+ E+ S + E ++ K + P K +++ S +
Sbjct: 611 EAKSPAEAKSPVKEEAKSPAEVKSPEKA----KSPTKEEAKSPEKAKSPEK-EEAKSPEK 665
Query: 397 SSSTIRIKTFSEVLAEKKHRQQEAERQKSK---KDTTCIKLKIDSEIKKTVVLPPIVASR 453
+ S ++ + S A+ + + +K+K K+ K S +K+ P S
Sbjct: 666 AKSPVKAEAKSPEKAKSPVKAEAKSPEKAKSPVKEEAKSPEKAKSPVKEEAKSPEKAKSP 725
Query: 454 GQSE-EPAGKTKSMQEVHIKTLEEIKLEKALRVQQSSESSTSSPSQHEATPGARRLLRIT 512
+ E + K KS + K+ E+ K + + +P++ EA A +
Sbjct: 726 VKEEAKTPEKAKSPVKEEAKSPEKAKSPEKAKTLDVKSPEAKTPAKEEARSPADKFPEKA 785
Query: 513 KRTGMKEEKNLQEGNEVDSQSSIRTEAKEASGETTGVDITKIQVKRCETMRE---KHMQK 569
K +E K+ ++ ++S ++ +AK E + K VK E +E K K
Sbjct: 786 KSPVKEEVKSPEK-----AKSPLKEDAKAPEKEIPKKEEVKSPVKEEEKPQEVKVKEPPK 840
Query: 570 QQEREKSVLTPLRGDVASCNTQVAEKPVLTAVPGITRHLTKRLPTKSSQKVEVETSGIGD 629
+ E EK+ TP + + A K P + + KVE + D
Sbjct: 841 KAEEEKAPATPKTEEKKDSKKEEAPKKEAPK-PKVEEKKEPAVEKPKESKVEAKKEEAED 899
Query: 630 SLLNVKCAAQTLEKRGKAKPKVNVKPSVVKVVSSPKLAPKRKAVEMHAAVIAAVKPLSSS 689
K T EK AK V+V K PK K +A +P +
Sbjct: 900 -----KKKVPTPEKEAPAK---------VEVKEDAK--PKEK------TEVAKKEPDDAK 937
Query: 690 SVLQEPPAKKAAVAVVPLVSEDKSVTVPEAENPRDSLVLPPTQSSSDSSPPEVSGPSSSQ 749
+ PA+K A E K +A+ P + P T++ + +S S
Sbjct: 938 AKEPSKPAEKKEAA-----PEKKDTKEEKAKKPEEK---PKTEAKAKEDDKTLSKEPSKP 989
Query: 750 MSMKTRRLSSA--STGKPPLSVEDD 772
+ K + SS KPP +D
Sbjct: 990 KAEKAEKSSSTDQKDSKPPEKATED 1014
Score = 52.0 bits (123), Expect = 2e-06
Identities = 107/550 (19%), Positives = 194/550 (35%), Gaps = 53/550 (9%)
Query: 218 EEIKSKKMKEKSKKQGEGSSGVSSLLLHPEPVPGPEKENVRTVVRTVTLSTKQGEEPLVR 277
EE+ ++ KE +++G+ G E G E+E K+ + P+
Sbjct: 468 EEVTEEEEKEAKEEEGKEEEGGEE-----EEAEGGEEETKSPPAEEAASPEKEAKSPVKE 522
Query: 278 LSLTERLGKRKFSAGGDSDPPLKRSLAQRLGKKVEAPETNIDKTPKKAQVSKSLKERLGM 337
+ + K S +K + K EA K+P+K + + +
Sbjct: 523 EAKSPAEAKSPEKEEAKSPAEVKSPEKAKSPAKEEAKSPPEAKSPEKEEAKSPAEVK--- 579
Query: 338 SADPDNEDATDKVNKVGEIHVKTLEEILLERASQKRGELQTKLKTEGPSKTDDSTSGARS 397
S + A ++ E + ++ ++ E ++ +K E S + +S
Sbjct: 580 SPEKAKSPAKEEAKSPAEAKSPEKAKSPVKEEAKSPAEAKSPVKEEAKSPAE-----VKS 634
Query: 398 SSTIRIKTFSEVLAEKKHRQQEAERQKSKKDTTCIKLKIDSEIKKTVVLPPIVASRGQSE 457
+ T E + +K + E E KS + K + +E K V + +S
Sbjct: 635 PEKAKSPTKEEAKSPEKAKSPEKEEAKSPEKA---KSPVKAEAKSPEKAKSPVKAEAKSP 691
Query: 458 EPAGKTKSMQEVHIKTLEEIKLEKALRVQQSSESSTSSPSQHEA-TPGARRLLRITKRTG 516
E K KS + K+ E+ K ++ + S SP + EA TP + +
Sbjct: 692 E---KAKSPVKEEAKSPEKAK--SPVKEEAKSPEKAKSPVKEEAKTPEKAKSPVKEEAKS 746
Query: 517 MKEEKNLQEGNEVDSQSSIRTEAKEASGETTGVDITKIQVKRCETMREKHMQKQQEREKS 576
++ K+ ++ +D +S EAK + E K K ++E+ K E+ KS
Sbjct: 747 PEKAKSPEKAKTLDVKSP---EAKTPAKEEARSPADKFPEKAKSPVKEE--VKSPEKAKS 801
Query: 577 VLTPLRGDVASCNTQVAEKPVLTAVPGITRHLTKRLPTKSSQKVEVETSGIGDSLLNVKC 636
PL+ D A+ P K +P K K V+ + +
Sbjct: 802 ---PLKED--------AKAP------------EKEIPKKEEVKSPVKEEEKPQEVKVKEP 838
Query: 637 AAQTLEKRGKAKPKVNVKPSVVKVVSSPKLAPKRKAVEMHAAVIAAVKPLSSSSVLQEPP 696
+ E++ A PK K K + K APK K E A KP S ++
Sbjct: 839 PKKAEEEKAPATPKTEEKKDSKKEEAPKKEAPKPKVEEKKEP--AVEKPKESKVEAKKEE 896
Query: 697 AKKAAVAVVPLVSEDKSVTVPEAENPRDSLVLPPTQSSSDSSPPEVSGPSSSQMSMKTRR 756
A+ P V V E P++ + + D+ E S P+ + + ++
Sbjct: 897 AEDKKKVPTPEKEAPAKVEVKEDAKPKEKTEV-AKKEPDDAKAKEPSKPAEKKEAAPEKK 955
Query: 757 LSSASTGKPP 766
+ K P
Sbjct: 956 DTKEEKAKKP 965
Score = 47.8 bits (112), Expect = 4e-05
Identities = 86/390 (22%), Positives = 147/390 (37%), Gaps = 45/390 (11%)
Query: 106 PESPEEEVKASQLSVQQNKLSVQSNPSPQLRSVMKVESSENVPSPTHPPVVINAADDDED 165
PE + VKA S ++ K V++ ++ V+ P PV ++ +
Sbjct: 663 PEKAKSPVKAEAKSPEKAKSPVKAEAKSPEKAKSPVKEEAKSPEKAKSPV----KEEAKS 718
Query: 166 DDDQFSEEGDETKTPTLQPTPEVHNGLRVTSVRKP----AVNIKQGECLNFGIKTLEEIK 221
+ S +E KTP +P + P +++K E EE +
Sbjct: 719 PEKAKSPVKEEAKTPEKAKSPVKEEAKSPEKAKSPEKAKTLDVKSPEAKT---PAKEEAR 775
Query: 222 S--KKMKEKSKKQGEGSSGVSSLLLHPEPVPGPEKENVRTVVRTV-----TLSTKQGEEP 274
S K EK+K S V + PE P KE+ + + + S + EE
Sbjct: 776 SPADKFPEKAK------SPVKEEVKSPEKAKSPLKEDAKAPEKEIPKKEEVKSPVKEEEK 829
Query: 275 LVRLSLTERLGKRKFSAGGDSDPPLKRSLAQRLGKKVEAPETNIDKTPKKAQVSKSLKER 334
+ + E K A + P ++ ++ KK EAP+ K + + ++++
Sbjct: 830 PQEVKVKEPPKK----AEEEKAPATPKTEEKKDSKKEEAPKKEAPKPKVEEKKEPAVEKP 885
Query: 335 LGMSADPDNEDATDKVNKVGEIHVKTLEEILLERASQKRGELQTKLKTEGPSKTDDSTSG 394
+ E+A DK V T E+ + K + + K KTE K D
Sbjct: 886 KESKVEAKKEEAEDKKK------VPTPEKEAPAKVEVKE-DAKPKEKTEVAKKEPDDAKA 938
Query: 395 ARSSSTIRIKTFSEVLAEKKHRQQEAERQKSKKDTTCIKLKIDSEIKKTVVLPPIVASRG 454
S K E EKK ++E ++ +K T K K D KT+ P S+
Sbjct: 939 KEPSKPAEKK---EAAPEKKDTKEEKAKKPEEKPKTEAKAKEDD---KTLSKEP---SKP 989
Query: 455 QSEEPAGKTKSMQEVHIKTLEEIKLEKALR 484
++E+ A K+ S + K E+ +KA +
Sbjct: 990 KAEK-AEKSSSTDQKDSKPPEKATEDKAAK 1018
Score = 36.2 bits (82), Expect = 0.13
Identities = 93/439 (21%), Positives = 164/439 (37%), Gaps = 37/439 (8%)
Query: 348 DKVNKVGEIHVKTLEEILLERASQKRGELQTKL-KTEGPSKTDDSTSGARSSSTIR---- 402
D++++ +++ + E ++ R +LQ + + E T DS RS R
Sbjct: 298 DRLSEAAKVNTDAMRSAQ-EEITEYRRQLQARTTELEALKSTKDSLERQRSELEDRHQAD 356
Query: 403 IKTFSEVL----AEKKHRQQEAERQ-KSKKDTTCIKLKIDSEIKKTVVLPPIVASR-GQS 456
I ++ E + AE ++ + E Q + +D +K+ +D EI L R G
Sbjct: 357 IASYQEAIQQLDAELRNTKWEMAAQLREYQDLLNVKMALDIEIAAYRKLLEGEECRIGFG 416
Query: 457 EEPAGKTKSMQEV-HIKTLEEIKLEKALRVQQSSESSTSS-PSQHEATPGARRLLRITKR 514
P + + ++ + T ++K E+ ++V + SE T Q E T + ++
Sbjct: 417 PIPFSLPEGLPKIPSVSTHIKVKSEEKIKVVEKSEKETVIVEEQTEETQVTEEVTEEEEK 476
Query: 515 TGMKEEKNLQEGNEVDSQSSIRTEAKEASGETTGVDITKIQVKRCETMREKHMQKQQERE 574
+EE +EG E + E K E + + E + K E+E
Sbjct: 477 EAKEEEGKEEEGGEEEEAEGGEEETKSPPAEEAASPEKEAKSPVKEEAKSPAEAKSPEKE 536
Query: 575 KSVLTPLRGDVASCNTQVAEKPVLTAVPGITRHLTKRLP-TKSSQKVEVETSGIGDSLLN 633
++ + + + A+ P + K P KS +K E ++ S
Sbjct: 537 EA-----KSPAEVKSPEKAKSP--------AKEEAKSPPEAKSPEKEEAKSPAEVKSPEK 583
Query: 634 VKCAAQTLEKR-GKAKPKVNVKPSVVKVVSSPKLAPKRKAVEMHAAVIAAVKPLSSSSVL 692
K A+ K +AK K V + SP A + V+ A A VK +
Sbjct: 584 AKSPAKEEAKSPAEAKSPEKAKSPVKEEAKSP--AEAKSPVKEEAKSPAEVKSPEKAKSP 641
Query: 693 QEPPAKKAAVAVVPLVSEDKSVTVPE-AENPRDSLVLPPTQSSSDSSPPEVSGPSSSQMS 751
+ AK A P E KS PE A++P + P ++ S E P ++
Sbjct: 642 TKEEAKSPEKAKSPEKEEAKS---PEKAKSPVKAEAKSPEKAKSPVK-AEAKSPEKAKSP 697
Query: 752 MKTRRLSSASTGKPPLSVE 770
+K S K P+ E
Sbjct: 698 VK-EEAKSPEKAKSPVKEE 715
>gi|52426735 ankyrin 2 isoform 1 [Homo sapiens]
Length = 3957
Score = 53.5 bits (127), Expect = 8e-07
Identities = 138/674 (20%), Positives = 234/674 (34%), Gaps = 132/674 (19%)
Query: 171 SEEGDETKTPTLQPTPEVHNGLRVTSVRKPAVNIKQGECLNFGIKTLEEIKSKKMKEKSK 230
S G K P + PT + SVR+ + G+ + L E KS K K+ +
Sbjct: 1964 SPSGKTEKQPPVSPTSKTERIEETMSVRELMKAFQSGQDPSKHKTGLFEHKSAKQKQPQE 2023
Query: 231 KQGEGSSGVSSLLLHPEPVPGPEKENVRTVVR---TVTLSTKQGEEPLVRLSLTERLGKR 287
K +L E + ++ R T T +K+G VR+S +G +
Sbjct: 2024 KGKVRVEKEKGPILTQREAQKTENQTIKRGQRLPVTGTAESKRG----VRVS---SIGVK 2076
Query: 288 KFSAGGDSDPPLKRSLAQRLGKKVEAPETNIDKTPKKAQVSKSLKERLGMSADPDNEDAT 347
K A G + L + + + E + PK+ + + + + PD + +T
Sbjct: 2077 KEDAAGGKEKVLSHKIPEPVQSVPEEESHRESEVPKEKMADE--QGDMDLQISPDRKTST 2134
Query: 348 D---------------------KVNKVGEIHVKT--------------LEEILLERASQK 372
D + + ++H+ +++ L S +
Sbjct: 2135 DFSEVIKQELEDNDKYQQFRLSEETEKAQLHLDQVLTSPFNTTFPLDYMKDEFLPALSLQ 2194
Query: 373 RGELQ---TKLKTEGPSKTD-----DSTSGARSSSTIRIKTFSEV---------LAEKKH 415
G L LK EG + + + T S + + + +E + KK
Sbjct: 2195 SGALDGSSESLKNEGVAGSPCGSLMEGTPQISSEESYKHEGLAETPETSPESLSFSPKKS 2254
Query: 416 RQQEAERQKSKKDTTCIKLKIDSEIKKTVVLPPIVASRGQSEEPAGKTKSMQEVHIKTLE 475
+Q E ++S K T +++ + E T + G SEE E + E
Sbjct: 2255 EEQTGETKESTKTETTTEIRSEKEHPTTKDIT------GGSEERGATVTEDSET---STE 2305
Query: 476 EIKLEKALRVQQSSESSTSSPSQHEATPGARRLLRITKRTGMKEEKNLQEGNEVDSQSSI 535
+ E L S TS Q + T L TG+ EE EG S+
Sbjct: 2306 SFQKEATL----GSPKDTSPKRQDDCTGSCSVALAKETPTGLTEEAACDEGQRTFGSSAH 2361
Query: 536 RTEAKEASGETTGVDITKIQVKRCETMREKHMQKQQEREKSVLTPLRGDVASCNTQVAEK 595
+T+ E+T + K++ P T+ +
Sbjct: 2362 KTQTDSEVQESTAT---------------------SDETKALPLPEASVKTDTGTESKPQ 2400
Query: 596 PVLTAVPGITRHLTKRLPTKSSQKVEVETSGIGDSLLNVKC-----AAQTLEKRGKAKPK 650
V+ + G L LP++ S+ + S + D L V A+ LE K
Sbjct: 2401 GVIRSPQG----LELALPSRDSEVL----SAVADDSLAVSHKDSLEASPVLEDNSSHKTP 2452
Query: 651 VNVKPSVVKVVSSPKLAPKRKAVEMHAAVIAAVKPLSSSSVLQEPPAKKAAVAVVPLVSE 710
+++PS +K +P R ++E + V+P + + AAVA L++E
Sbjct: 2453 DSLEPSPLKE------SPCRDSLES-----SPVEPKMKAGIFPSHFPLPAAVAKTELLTE 2501
Query: 711 DKSVTV-----PEAENPRDSLVLPPTQSSSDSSPPEVSGPSSSQMSMK-TRRLSSASTGK 764
SV P+ DSL SS SP PSS ++S + T + + ST K
Sbjct: 2502 VASVRSRLLRDPDGSAEDDSLEQTSLMESSGKSPLSPDTPSSEEVSYEVTPKTTDVSTPK 2561
Query: 765 PPL----SVEDDFE 774
P + + EDD E
Sbjct: 2562 PAVIHECAEEDDSE 2575
Score = 49.7 bits (117), Expect = 1e-05
Identities = 104/482 (21%), Positives = 177/482 (36%), Gaps = 77/482 (15%)
Query: 347 TDKVNKVGEIHVKTLEEILLERASQKRGELQTKLKTEGPSKTDDSTSGA--RSSSTIRIK 404
TD +K G I VK L + E + E+ ++K + + SG R S+++
Sbjct: 1523 TDVSDKAGSIKVKELVKAAEEEPGEPF-EIVERVKEDLEKVNEILRSGTCTRDESSVQSS 1581
Query: 405 TFSEVLAEKK-----HRQQEAERQKSKKDTT---CIKLKIDSEIKKTVVLPPIVASRGQS 456
L E++ + E RQK+ + T C++++ID EIK G+
Sbjct: 1582 RSERGLVEEEWVIVSDEEIEEARQKAPLEITEYPCVEVRIDKEIK------------GKV 1629
Query: 457 EEPAGKTKSMQEVHIKTLEEIKLEKALRVQQSSESSTSSPSQHEATPGARRLLRITKRTG 516
E+ + + + T + E+ VQ + G + R+
Sbjct: 1630 EKDSTGLVNYLTDDLNTCVPLPKEQLQTVQDKA--------------GKKCEALAVGRSS 1675
Query: 517 MKEEKNLQEGNEVDSQSSIRTEAKEASGETTGVDITKIQVKRCETMREKHMQKQQEREKS 576
KE K++ D S + + K + G K V+R ++EK QK++ + S
Sbjct: 1676 EKEGKDIPP----DETQSTQKQHKPSLG-------IKKPVRR--KLKEKQKQKEEGLQAS 1722
Query: 577 VLTPLRGDVASCNTQVAEKPVLTAVPGITRHLTKRLPTKSSQKVEVETSGIGDSLLNVKC 636
S + E P L P LPT + +E + IG VK
Sbjct: 1723 A-EKAELKKGSSEESLGEDPGLAPEP---------LPTVKATSPLIEETPIGSIKDKVKA 1772
Query: 637 AAQTLEKRGKAKPKVNVKPSVVKVVSSPKLAPKRKAVEMHAAVIAAVKPLSSSSVLQEPP 696
+ +E K + K+ ++ V + PK+ H A ++K + P
Sbjct: 1773 LQKRVEDEQKGRSKLPIR------VKGKEDVPKKTTHRPHPAASPSLKSERHAPGSPSPK 1826
Query: 697 AKKAAVAVVPLVSEDKSVTVPEAENPRDSLVLPPTQS-----SSDSSPPEVSGPSSSQMS 751
++ + +E P ++ + S V P ++ +S SS E P S S
Sbjct: 1827 TERHSTLSSSAKTERHPPVSPSSKTEKHSPVSPSAKTERHSPASSSSKTEKHSPVSP--S 1884
Query: 752 MKTRRLSSASTGK----PPLSVEDDFEKLIWEISGGKLEAEIDLDPGKDEDDLLLELSEM 807
KT R S S+ K PP+S +K G+ E + PG+ E L + S
Sbjct: 1885 TKTERHSPVSSTKTERHPPVSPSGKTDKRPPVSPSGRTEKHPPVSPGRTEKRLPVSPSGR 1944
Query: 808 ID 809
D
Sbjct: 1945 TD 1946
>gi|41281453 serine/threonine kinase 2 [Homo sapiens]
Length = 1235
Score = 50.1 bits (118), Expect = 8e-06
Identities = 118/554 (21%), Positives = 221/554 (39%), Gaps = 58/554 (10%)
Query: 225 MKEKSKKQGEGSSGVSSLLLHP-------EPVPGPEKENVRTVVRTVTLSTKQGEEPLVR 277
+K+ +K + S LL HP +P+ E V V ++ EE
Sbjct: 269 LKKCLEKNVDARWTTSQLLQHPFVTVDSNKPIRELIAEAKAEVTEEVEDGKEEDEEEETE 328
Query: 278 LSLTERLGKRKFS----AGGDSDPPLKRS-LAQRLGKKVEAPETNIDKTPKKAQVSKSLK 332
SL KR S A + D + + + + + +K E + DK K K
Sbjct: 329 NSLPIPASKRASSDLSIASSEEDKLSQNACILESVSEKTERSNSE-DKLNSKILNEKPTT 387
Query: 333 ERLGMSADPDNEDATD-KVNKVGEIHVKTLEEILLERASQKRGELQTKLKTEGPSKTDDS 391
+ + + NE TD ++ + E+H +T ++ E +KR +L+ TE D +
Sbjct: 388 DEPEKAVEDINEHITDAQLEAMTELHDRTA--VIKENEREKRPKLENLPDTEDQETVDIN 445
Query: 392 TSGARSSSTIRIKTFSEVLAEKKHRQQEAERQKSKKDTTCIKLKIDSEIKKTVVLPPIVA 451
+ + I I + + + + + E E+ + K+ KL EIK T++ +
Sbjct: 446 SVSEGKENNIMITLETNI---EHNLKSEEEKDQEKQQMFENKLIKSEEIKDTILQTVDLV 502
Query: 452 SRGQSEEPAGKTKSMQEVHI-KTLEEIKLEKALRVQQSSESSTSSP-SQHEATPGARRLL 509
S+ E+ A EV + K + KL + + Q+ S+TS EA A+++
Sbjct: 503 SQETGEKEANIQAVDSEVGLTKEDTQEKLGEDDKTQKDVISNTSDVIGTCEAADVAQKVD 562
Query: 510 RITKR-TGMKEEKNLQE-GNEVDSQSSIRTEAKEASGETTGVDITKIQVKRCETMREKHM 567
+ T + K + E G ++ ++ + EA G T V I +I V+ E K+
Sbjct: 563 EDSAEDTQSNDGKEVVEVGQKLINKPMVGPEA----GGTKEVPIKEI-VEMNEIEEGKNK 617
Query: 568 QKQQEREKSVLTPLRGDVASCNTQVAEKPVLTAVPGITRHLTKRLPTKSSQKVEVETSGI 627
++ ++++ + E+P T IT + S + + +
Sbjct: 618 EQAINSSENIM------------DINEEPGTTEGEEITESSSTEEMEVRSVVADTDQKAL 665
Query: 628 GDSLLNVKCAAQTLEKRGKAKPKVNVKPSVVKVVSSPKLAPKRKAVEMHAAVIAAVKPLS 687
G + + ++K K P K V VVS P E +I ++ S
Sbjct: 666 GSEVQDASKVTTQIDKEKKEIPVSIKKEPEVTVVSQP--------TEPQPVLIPSININS 717
Query: 688 SSSVLQEPPAKKAAVAVVPLVSEDKSVTVPEAENPRDSLVLPPTQSSSDSSPPEVSGPSS 747
S +E + +S+ +++ PE+ENP+++ T S++D+S +++ S
Sbjct: 718 DSGENKEE---------IGSLSKTETILPPESENPKENDNDSGTGSTADTSSIDLNLSIS 768
Query: 748 SQMSMKTRRLSSAS 761
S +S KT+ S S
Sbjct: 769 SFLS-KTKDSGSIS 781
Score = 33.9 bits (76), Expect = 0.62
Identities = 91/409 (22%), Positives = 158/409 (38%), Gaps = 74/409 (18%)
Query: 156 VINAADDDEDDDDQFSEEGDETKTPTLQPTPEVHNGLRVTSVRKPAVNIKQGECLNFGIK 215
V D+D +D Q S +G E V G ++ + KP V + G IK
Sbjct: 557 VAQKVDEDSAEDTQ-SNDGKEV----------VEVGQKL--INKPMVGPEAGGTKEVPIK 603
Query: 216 TLEEIKSKKMKEKSKKQGEGSSGVSSLLLHPEPVPGPEKENVRTVVRTVTLSTKQGEEPL 275
+ E+ +++E K+ +S + + ++ EP T +GEE +
Sbjct: 604 EIVEMN--EIEEGKNKEQAINSSENIMDINEEP------------------GTTEGEE-I 642
Query: 276 VRLSLTERLGKRKFSAGGDSDPPLKRSLAQRLGKKVEAPETNIDKTPKKAQVSKSLKERL 335
S TE + R A D+D S Q K T IDK K+ VS + +
Sbjct: 643 TESSSTEEMEVRSVVA--DTDQKALGSEVQDASKVT----TQIDKEKKEIPVSIKKEPEV 696
Query: 336 GMSADPDNEDAT--DKVNKVGEIHVKTLEEILLERASQKRGELQTKLKTEGPSKTDDSTS 393
+ + P +N + + EEI S + E ++E P + D+ +
Sbjct: 697 TVVSQPTEPQPVLIPSIN-INSDSGENKEEI----GSLSKTETILPPESENPKENDNDSG 751
Query: 394 GARSSSTIRIK---TFSEVLAEKKHRQ----QEAERQKSKKDTTCIKLKIDSEIKKTVVL 446
++ T I + S L++ K QE RQK T K +D ++ +V
Sbjct: 752 TGSTADTSSIDLNLSISSFLSKTKDSGSISLQETRRQKKTLKKTR-KFIVDG-VEVSVTT 809
Query: 447 PPIVASRGQSEEPAGKTKSMQEVHIKTLEEIKLEKALRVQQSSESSTSSPSQHEATPGAR 506
IV + KT+ ++ + + L E++ + + +Q ++ +S Q + R
Sbjct: 810 SKIVT------DSDSKTEELRFLRRQELRELRFLQ--KEEQRAQQQLNSKLQQQREQIFR 861
Query: 507 RL---LRITKRTGMKEEKNLQ-------EGNEVDSQSSIRTEAKEASGE 545
R + KR +E +NL+ E E + + +R EAK GE
Sbjct: 862 RFEQEMMSKKRQYDQEIENLEKQQKQTIERLEQEHTNRLRDEAKRIKGE 910
>gi|71361682 nuclear mitotic apparatus protein 1 [Homo sapiens]
Length = 2115
Score = 48.9 bits (115), Expect = 2e-05
Identities = 89/386 (23%), Positives = 162/386 (41%), Gaps = 55/386 (14%)
Query: 258 RTVVRTVTLSTKQGEEPLVRLSLTERLGKRKFSAGGDSDPPLKRSLAQRLGKKVEAPETN 317
+ V R TL K GE+ + + + L K AG D P L ++ G++ + +
Sbjct: 914 KEVARLETLVRKAGEQ---QETASRELVKEPARAG-DRQPEW---LEEQQGRQFCSTQAA 966
Query: 318 IDKTPKKAQVSKSLKERLGMSADPDNEDATDKVNKVGEIHVKTLEEILLERASQKRGELQ 377
+ ++A+ + ERL + E + + G+ +E + R +Q+RG Q
Sbjct: 967 LQAMEREAEQMGNELERLRAAL---MESQGQQQEERGQ------QEREVARLTQERGRAQ 1017
Query: 378 TKLKTEGPSKTDDST--SGARSSSTIRIKTFSEVLAEKKHRQQEAERQKSK-KDTTCIKL 434
L E ++ + A + + T E LA ++ +++ +K + ++
Sbjct: 1018 ADLALEKAARAELEMRLQNALNEQRVEFATLQEALAHALTEKEGKDQELAKLRGLEAAQI 1077
Query: 435 KIDSEIKKTVV-LPPIVASR--------GQSEEPAGKTKSM-QEVHIKTLEEIKLEKALR 484
K E+++TV L +A + G E AG+T+ ++ E KLE+ +
Sbjct: 1078 KELEELRQTVKQLKEQLAKKEKEHASGSGAQSEAAGRTEPTGPKLEALRAEVSKLEQQCQ 1137
Query: 485 VQQSSESSTSSPSQHEATPGARRLLRITKRTGMKEEKNLQEGNEVDSQSSIRTEAKEASG 544
QQ S + E A R + G EEK + G+ SQS++ + +E +
Sbjct: 1138 KQQEQADSLERSLEAERASRAERDSALETLQGQLEEKAQELGH---SQSALASAQRELAA 1194
Query: 545 ETTGV-------DITKIQVKRCETMREKHMQKQQEREKSVLTPLRGDVASCNTQVAEKPV 597
T V D K QV R +++ ER+ S+++ L +V+ N QV EK
Sbjct: 1195 FRTKVQDHSKAEDEWKAQVAR--------GRQEAERKNSLISSLEEEVSILNRQVLEK-- 1244
Query: 598 LTAVPGITRHLTKRLPTKS--SQKVE 621
G ++ L + + +S SQK+E
Sbjct: 1245 ----EGESKELKRLVMAESEKSQKLE 1266
Score = 36.2 bits (82), Expect = 0.13
Identities = 93/420 (22%), Positives = 163/420 (38%), Gaps = 61/420 (14%)
Query: 201 AVNIKQGECLNFGIKTLEEIKSKKMKEKSKKQGEGSSGVSSLLLHPEPVPGPEKENVRTV 260
A IK+ E L +K L+E +KK KE GS S EP GP+ E +R
Sbjct: 1074 AAQIKELEELRQTVKQLKEQLAKKEKE----HASGSGAQSEAAGRTEPT-GPKLEALRAE 1128
Query: 261 VRTVTLSTKQGEE---PLVRLSLTERLGKRKFSAGGDSDPPLKRSLAQRLG--------- 308
V + ++ +E L R ER + + + ++ AQ LG
Sbjct: 1129 VSKLEQQCQKQQEQADSLERSLEAERASRAERDSALETLQGQLEEKAQELGHSQSALASA 1188
Query: 309 -KKVEAPETNIDKTPKKAQVSKSLKERLGMSADPDNEDATDKVNKVGEIHVKTLE----- 362
+++ A T + K K+ R A+ N + +V ++ + LE
Sbjct: 1189 QRELAAFRTKVQDHSKAEDEWKAQVARGRQEAERKNSLISSLEEEVSILNRQVLEKEGES 1248
Query: 363 ---EILLERASQKRGELQTKLKTEGPSKTDDSTSGARSSSTIRIKTFSEVLAEKKHRQQE 419
+ L+ S+K +L+ +L+ +S A SS +R E + ++E
Sbjct: 1249 KELKRLVMAESEKSQKLEERLRLLQAETASNSARAAERSSALR--------EEVQSLREE 1300
Query: 420 AERQKSKKDTTCIKLKIDSEIKKTVVLPPIVASRGQSEEPAGKTKSMQEVHIKTLEEIKL 479
AE+Q+ + +L +E ++EE + K+ QE + +
Sbjct: 1301 AEKQRVASENLRQELTSQAE---------------RAEELGQELKAWQE------KFFQK 1339
Query: 480 EKALRVQQSSESSTSSPSQHEATPGARRLLRITKRTGMKEEKNLQEGNEVDSQSS--IRT 537
E+AL Q +ST + E P A+ L + + EK +E E Q++ +R
Sbjct: 1340 EQALSTLQLEHTSTQA-LVSELLP-AKHLCQQLQAEQAAAEKRHREELEQSKQAAGGLRA 1397
Query: 538 EAKEASGETTGVDITKIQVKRCE-TMREKHMQKQQEREK-SVLTPLRGDVASCNTQVAEK 595
E A E + + +V E T ++ +K E+ S+L G +A N + E+
Sbjct: 1398 ELLRAQRELGELIPLRQKVAEQERTAQQLRAEKASYAEQLSMLKKAHGLLAEENRGLGER 1457
Score = 30.0 bits (66), Expect = 9.0
Identities = 48/291 (16%), Positives = 108/291 (37%), Gaps = 36/291 (12%)
Query: 301 RSLAQRLGKKVEAPETNIDKTPKKAQVSKS-LKERLGMSADPDNEDATDKVNKVGEIHVK 359
R ++L ++ E + + +K + ++ ++L +A+ ++ + +K
Sbjct: 550 RHQVEQLSSSLKQKEQQLKEVAEKQEATRQDHAQQLATAAEEREASLRER-----DAALK 604
Query: 360 TLEEILLERASQKRGELQTKLKTEGPSKTDDSTSGAR--------SSSTIRIKTFSEVLA 411
LE + E+A+ K LQ +L+ ++ TS + S ++ E
Sbjct: 605 QLEALEKEKAA-KLEILQQQLQVANEARDSAQTSVTQAQREKAELSRKVEELQACVETAR 663
Query: 412 EKKHRQQ----------EAERQKSKKDTTCIKLKIDSEIKKTVVLPPIVASRGQSEEPAG 461
+++H Q +E+QK+ + + K + + + + ++G EE
Sbjct: 664 QEQHEAQAQVAELELQLRSEQQKATEKERVAQEKDQLQEQLQALKESLKVTKGSLEEEKR 723
Query: 462 KTKSMQEVHIKTLEEIKLEKALRVQQSSESSTSSPSQHEATPGARRLLRITKRTGMKEEK 521
+ E + + E+K E V+Q + G L +
Sbjct: 724 RAADALEEQQRCISELKAETRSLVEQHKRERKELEEERAGRKGLEARL-----------Q 772
Query: 522 NLQEGNEVDSQSSIRTEAKEASGETTGVDITKIQVKRCETMREKHMQKQQE 572
L E ++ +++ R A+ + + T + VK RE++ QQE
Sbjct: 773 QLGEAHQAETEVLRRELAEAMAAQHTAESECEQLVKEVAAWRERYEDSQQE 823
>gi|84043963 eukaryotic translation initiation factor 5B [Homo
sapiens]
Length = 1220
Score = 48.9 bits (115), Expect = 2e-05
Identities = 90/448 (20%), Positives = 166/448 (37%), Gaps = 50/448 (11%)
Query: 164 EDDDDQFSEEGDETKTPTLQPTPEVHNGLR----VTSVRKPAVNIKQGECLNFGIKTLEE 219
+D+D + E+ D T +P E+++G + K A Q + +E
Sbjct: 109 DDNDSEELEDKDSKSKKTAKPKVEMYSGSDDDDDFNKLPKKAKGKAQKSNKKWDGSEEDE 168
Query: 220 IKSKKMKEKSKKQGEGSSGVSS---------LLLHPEPVPGP------EKENVRTVVRTV 264
SKK+KE+S+ G SG S + + PGP E ++ ++TV
Sbjct: 169 DNSKKIKERSRINSSGESGDESDEFLQSRKGQKKNQKNKPGPNIESGNEDDDASFKIKTV 228
Query: 265 TLSTKQGEEPLVRLSLTERLGKRKFSAGGDSDPPLKRSLAQRLGKKVEAPETNIDKTPKK 324
+ +E + E+ RK + + K Q+ ++ ET K
Sbjct: 229 AQKKAEKKERERKKRDEEKAKLRKLKEKEELETGKKDQSKQKESQRKFEEETVKSKVTVD 288
Query: 325 AQVSKSLKER--LGMSADPDNE---DATDKVNKVGEIHVKTLEEILLERASQKRGELQTK 379
V + +E+ +A+ DNE DK K GE K E +K+G +
Sbjct: 289 TGVIPASEEKAETPTAAEDDNEGDKKKKDKKKKKGEKEEKEKE--------KKKGPSKAT 340
Query: 380 LKT--EGPSKTDDSTSGARSSSTIRIKTFSEVLAEKKH----RQQEAERQKSKKDTTCIK 433
+K E +K + + RIK E+ A++K Q++ ER+K K+ +
Sbjct: 341 VKAMQEALAKLKEEEERQKREEEERIKRLEELEAKRKEEERLEQEKRERKKQKEKERKER 400
Query: 434 LKIDSEIKKTVVLPPIVASRGQSEEPAGKTKSMQEVHIKTLEEIKLEKAL-------RVQ 486
LK K+ +L E K Q V + + + + ++ + ++
Sbjct: 401 LK-----KEGKLLTKSQREARARAEATLKLLQAQGVEVPSKDSLPKKRPIYEDKKRKKIP 455
Query: 487 QSSESSTSSPSQHEATPGARRLLRITKRTGMKEEKNLQEGNEVDSQSSIRTEAKEASGET 546
Q ES S S + ++ +E + + EA + ET
Sbjct: 456 QQLESKEVSESMELCAAVEVMEQGVPEKEETPPPVEPEEEEDTEDAGLDDWEAMASDEET 515
Query: 547 TGVDITKIQVKRCETMREKHMQKQQERE 574
V+ K+ ++ E E+ ++++E E
Sbjct: 516 EKVEGNKVHIEVKENPEEEEEEEEEEEE 543
Score = 34.3 bits (77), Expect = 0.48
Identities = 89/512 (17%), Positives = 191/512 (37%), Gaps = 64/512 (12%)
Query: 304 AQRLGKKVEAPETNIDKTPKKAQVSKSLKERLGMSADPDNEDATDKVNKVGEIHVKTLE- 362
A R V+ E N ++ K + K K + D D+E+ DK +K + +E
Sbjct: 74 ADRETVAVKPTENNEEEFTSKDKKKKGQKGKKQSFDDNDSEELEDKDSKSKKTAKPKVEM 133
Query: 363 -------EILLERASQKRGELQ-TKLKTEGPSKTDDSTSGARSSSTIRIKTFSEVLAEK- 413
+ + + +G+ Q + K +G + +D++ + S I S +++
Sbjct: 134 YSGSDDDDDFNKLPKKAKGKAQKSNKKWDGSEEDEDNSKKIKERSRINSSGESGDESDEF 193
Query: 414 -KHRQQEAERQKSKKDTTCIKLKIDSEIKKTVVLPPIVASRGQSEEPAGKTKSMQEVHIK 472
+ R+ + + QK+K D + + + + + + +E K + ++ ++
Sbjct: 194 LQSRKGQKKNQKNKPGPNIESGNEDDD--ASFKIKTVAQKKAEKKERERKKRDEEKAKLR 251
Query: 473 TLEEIKLEKALRVQQSSESSTSSPSQHEATPGARRLLRITKRTGMKEEKNLQEGNEVDSQ 532
L+E + + + QS + + + E ++T TG+
Sbjct: 252 KLKEKEELETGKKDQSKQKESQRKFEEETVKS-----KVTVDTGV--------------- 291
Query: 533 SSIRTEAKEASGETTGVDITKIQVKRCETMREKHMQKQQEREKSVLTPLRGDVASCNTQV 592
I ++A T D + K+ + ++K ++++E+EK
Sbjct: 292 --IPASEEKAETPTAAEDDNEGDKKKKDKKKKKGEKEEKEKEKK---------------- 333
Query: 593 AEKPVLTAVPGITRHLTKRLPTKSSQKVEVETSGIGDSLLNVK-CAAQTLEKRGKAKPKV 651
+ P V + L K + QK E E L K + LE+ + + K
Sbjct: 334 -KGPSKATVKAMQEALAKLKEEEERQKREEEERIKRLEELEAKRKEEERLEQEKRERKKQ 392
Query: 652 NVKPSVVKVVSSPKLAPKRKAVEMHAAVIAAVKPLSSSSVLQEPPAKKAAVAVVPLVSED 711
K ++ KL K + E A A +K L + V E P+K + P+ +
Sbjct: 393 KEKERKERLKKEGKLLTKSQR-EARARAEATLKLLQAQGV--EVPSKDSLPKKRPIYEDK 449
Query: 712 KSVTVP---EAENPRDSLVLPPTQSSSDSSPPE-VSGPSSSQMSMKTRRLSSASTGKPPL 767
K +P E++ +S+ L + PE P + + + +
Sbjct: 450 KRKKIPQQLESKEVSESMELCAAVEVMEQGVPEKEETPPPVEPEEEEDTEDAGLDDWEAM 509
Query: 768 SVEDDFEKLIWEISGGKLEAEIDLDPGKDEDD 799
+ +++ EK + G K+ E+ +P ++E++
Sbjct: 510 ASDEETEK----VEGNKVHIEVKENPEEEEEE 537
>gi|38045898 RAB6-interacting protein 2 isoform epsilon [Homo
sapiens]
Length = 1116
Score = 48.5 bits (114), Expect = 2e-05
Identities = 82/362 (22%), Positives = 153/362 (42%), Gaps = 44/362 (12%)
Query: 302 SLAQRLGKKVEAPETNIDK---TPKKAQVSKSLK-ERLGMSADPDNEDATDKVNKVGEIH 357
SL +R+ K ++A TN D T ++A K ERL D D + ++++ +
Sbjct: 596 SLKERV-KSLQADTTNTDTALTTLEEALAEKERTIERLKEQRDRDEREKQEEIDN----Y 650
Query: 358 VKTLEEILLERASQKRGELQTK------LKTEGPSKTDDSTSGARSSSTIRIKTFSEVLA 411
K L++ L E+ S +G+L K LK S ++SG + S R+KT L
Sbjct: 651 KKDLKD-LKEKVSLLQGDLSEKEASLLDLKEHASSL---ASSGLKKDS--RLKTLEIALE 704
Query: 412 EKKHRQQEAERQKSKKDTTCIKLKIDSEIKKTVVLPPIVASRGQSEEPAGKTKSMQEVHI 471
+KK + E Q K ++ + E+ + +R + E + K ++ + +
Sbjct: 705 QKKEECLKMESQLKKAHEAALEARASPEMSDRIQHLEREITRYKDE--SSKAQAEVDRLL 762
Query: 472 KTLEEIKLEKALRVQQSSESSTSSPSQHEATPGARRLLRITKRTG--MKEEKNLQEGNEV 529
+ L+E++ EK + ++ +E Q++ + ++ K+ M EE +E N
Sbjct: 763 EILKEVENEKNDKDKKIAELERQVKDQNKKVANLKHKEQVEKKKSAQMLEEARRREDNLN 822
Query: 530 DS----QSSIR------TEAKEASGETTGV----DITKIQVKRCETMREKHMQK---QQE 572
DS Q S+R E +EA E+ + ++ Q + T EK +++ E
Sbjct: 823 DSSQQLQDSLRKKDDRIEELEEALRESVQITAEREMVLAQEESARTNAEKQVEELLMAME 882
Query: 573 REKSVLTPLRGDVASCNTQVAEKPVLTAVPGITRHLTKRLPTKSSQKVEVETSGIGDSLL 632
+ K L ++ ++S +AEK T + + K L K E + I +
Sbjct: 883 KVKQELESMKAKLSSTQQSLAEKE--THLTNLRAERRKHLEEVLEMKQEALLAAISEKDA 940
Query: 633 NV 634
N+
Sbjct: 941 NI 942
>gi|38045896 RAB6-interacting protein 2 isoform delta [Homo sapiens]
Length = 1088
Score = 48.5 bits (114), Expect = 2e-05
Identities = 82/362 (22%), Positives = 153/362 (42%), Gaps = 44/362 (12%)
Query: 302 SLAQRLGKKVEAPETNIDK---TPKKAQVSKSLK-ERLGMSADPDNEDATDKVNKVGEIH 357
SL +R+ K ++A TN D T ++A K ERL D D + ++++ +
Sbjct: 568 SLKERV-KSLQADTTNTDTALTTLEEALAEKERTIERLKEQRDRDEREKQEEIDN----Y 622
Query: 358 VKTLEEILLERASQKRGELQTK------LKTEGPSKTDDSTSGARSSSTIRIKTFSEVLA 411
K L++ L E+ S +G+L K LK S ++SG + S R+KT L
Sbjct: 623 KKDLKD-LKEKVSLLQGDLSEKEASLLDLKEHASSL---ASSGLKKDS--RLKTLEIALE 676
Query: 412 EKKHRQQEAERQKSKKDTTCIKLKIDSEIKKTVVLPPIVASRGQSEEPAGKTKSMQEVHI 471
+KK + E Q K ++ + E+ + +R + E + K ++ + +
Sbjct: 677 QKKEECLKMESQLKKAHEAALEARASPEMSDRIQHLEREITRYKDE--SSKAQAEVDRLL 734
Query: 472 KTLEEIKLEKALRVQQSSESSTSSPSQHEATPGARRLLRITKRTG--MKEEKNLQEGNEV 529
+ L+E++ EK + ++ +E Q++ + ++ K+ M EE +E N
Sbjct: 735 EILKEVENEKNDKDKKIAELERQVKDQNKKVANLKHKEQVEKKKSAQMLEEARRREDNLN 794
Query: 530 DS----QSSIR------TEAKEASGETTGV----DITKIQVKRCETMREKHMQK---QQE 572
DS Q S+R E +EA E+ + ++ Q + T EK +++ E
Sbjct: 795 DSSQQLQDSLRKKDDRIEELEEALRESVQITAEREMVLAQEESARTNAEKQVEELLMAME 854
Query: 573 REKSVLTPLRGDVASCNTQVAEKPVLTAVPGITRHLTKRLPTKSSQKVEVETSGIGDSLL 632
+ K L ++ ++S +AEK T + + K L K E + I +
Sbjct: 855 KVKQELESMKAKLSSTQQSLAEKE--THLTNLRAERRKHLEEVLEMKQEALLAAISEKDA 912
Query: 633 NV 634
N+
Sbjct: 913 NI 914
>gi|41322923 plectin 1 isoform 11 [Homo sapiens]
Length = 4547
Score = 48.1 bits (113), Expect = 3e-05
Identities = 79/375 (21%), Positives = 151/375 (40%), Gaps = 39/375 (10%)
Query: 301 RSLAQRLGKKVEAPETNIDKTPKKAQVSKSLKERLGMSADPDNEDAT-----------DK 349
RS +++ +++EA + ++A ++L E EDA +K
Sbjct: 1779 RSTSEKSKQRLEAEAGRFRELAEEAARLRALAEEAKRQRQLAEEDAARQRAEAERVLAEK 1838
Query: 350 VNKVGEI-HVKTLEEILLERASQKRGELQTKLKTEGPSKTDDSTSGARSSSTIRIKTFSE 408
+ +GE +KT EI L+ + L+ + E + A+ + I E
Sbjct: 1839 LAAIGEATRLKTEAEIALKEKEAENERLRRLAEDEAFQRRRLEEQAAQHKADIE-----E 1893
Query: 409 VLAE-KKHRQQEAERQKSK-KDTTCIKLKIDSEIKKTVV-LPPIVASRGQSEEPAGKTKS 465
LA+ +K E ERQK +DT + +++ EI A + + E G+ +S
Sbjct: 1894 RLAQLRKASDSELERQKGLVEDTLRQRRQVEEEILALKASFEKAAAGKAELELELGRIRS 1953
Query: 466 MQEVHIKTLEEIKLEKALRVQQSSESSTSSPSQHEATPGARRLLRITKRTGMKEEKNLQE 525
E +++ E+ +LE A + Q ++E + EA ++ L + + + L+E
Sbjct: 1954 NAEDTLRSKEQAELEAARQRQLAAEEERR---RREAEERVQKSLAAEEEAARQRKAALEE 2010
Query: 526 GN----EVDSQSSIRTEAKEASGETTGVDITKIQVKRCETMREKH----MQKQQE----- 572
+V+ +R A++ S + Q KR + + H QK+QE
Sbjct: 2011 VERLKAKVEEARRLRERAEQESARQLQLAQEAAQ-KRLQAEEKAHAFAVQQKEQELQQTL 2069
Query: 573 -REKSVLTPLRGDVASCNTQVAEKPVLTAVPGITRHLTKRLPTKSSQKVEVETSGIGDSL 631
+E+SVL LRG+ A + AE+ V R + +++++ +
Sbjct: 2070 QQEQSVLDQLRGE-AEAARRAAEEAEEARVQAEREAAQSRRQVEEAERLKQSAEEQAQAR 2128
Query: 632 LNVKCAAQTLEKRGK 646
+ AA+ L K +
Sbjct: 2129 AQAQAAAEKLRKEAE 2143
Score = 38.5 bits (88), Expect = 0.025
Identities = 66/335 (19%), Positives = 136/335 (40%), Gaps = 53/335 (15%)
Query: 304 AQRLGKKVEAPETNIDKTPKKAQVSKSLKERLGMSADPDNE-----DATDKVNKVGEIHV 358
A+RL ++V+ D++ +K Q L R+ A+ E A +++ E
Sbjct: 1496 AERLRRQVQ------DESQRKRQAEVELASRVKAEAEAAREKQRALQALEELRLQAEEAE 1549
Query: 359 KTLEEILLERASQKRGELQTKLKTEGPSKTDDSTSGARSSSTIRIKTFSEVLAEKKHRQQ 418
+ L + +ERA Q + L+T A+ S+ +++ AEK
Sbjct: 1550 RRLRQAEVERARQVQVALET----------------AQRSAEAELQSKRASFAEKT---A 1590
Query: 419 EAERQKSKKDTTCIKLKIDSEIKKTVVLPPIVASRGQSEEPAGKTKSMQEVHIKTLEEIK 478
+ ER ++ +L+ ++E R Q + A + + E ++ + +K
Sbjct: 1591 QLERSLQEEHVAVAQLREEAE------------RRAQQQAEAERAREEAERELERWQ-LK 1637
Query: 479 LEKALRVQQSSE--SSTSSPSQHEATPGARRLLRITKRTGMKEEKNLQEGNEVDSQSSIR 536
+ALR++ +E + S +Q EA R +R G EE+ +++ + + +
Sbjct: 1638 ANEALRLRLQAEEVAQQKSLAQAEAEKQKEEAEREARRRGKAEEQAVRQRELAEQELEKQ 1697
Query: 537 TEAKEASGETTGVDITKIQVKRCETMREKHMQK-------QQEREKSVLTPLRGDVASCN 589
+ E + + ++ R ET + + ++ + +RE + T R ++ +
Sbjct: 1698 RQLAEGTAQQRLAAEQELIRLRAETEQGEQQRQLLEEELARLQREAAAATQKRQELEAEL 1757
Query: 590 TQV-AEKPVLTAVPGITRHLTKRLPTKSSQKVEVE 623
+V AE VL A ++ KS Q++E E
Sbjct: 1758 AKVRAEMEVLLASKARAEEESRSTSEKSKQRLEAE 1792
>gi|41322914 plectin 1 isoform 10 [Homo sapiens]
Length = 4551
Score = 48.1 bits (113), Expect = 3e-05
Identities = 79/375 (21%), Positives = 151/375 (40%), Gaps = 39/375 (10%)
Query: 301 RSLAQRLGKKVEAPETNIDKTPKKAQVSKSLKERLGMSADPDNEDAT-----------DK 349
RS +++ +++EA + ++A ++L E EDA +K
Sbjct: 1783 RSTSEKSKQRLEAEAGRFRELAEEAARLRALAEEAKRQRQLAEEDAARQRAEAERVLAEK 1842
Query: 350 VNKVGEI-HVKTLEEILLERASQKRGELQTKLKTEGPSKTDDSTSGARSSSTIRIKTFSE 408
+ +GE +KT EI L+ + L+ + E + A+ + I E
Sbjct: 1843 LAAIGEATRLKTEAEIALKEKEAENERLRRLAEDEAFQRRRLEEQAAQHKADIE-----E 1897
Query: 409 VLAE-KKHRQQEAERQKSK-KDTTCIKLKIDSEIKKTVV-LPPIVASRGQSEEPAGKTKS 465
LA+ +K E ERQK +DT + +++ EI A + + E G+ +S
Sbjct: 1898 RLAQLRKASDSELERQKGLVEDTLRQRRQVEEEILALKASFEKAAAGKAELELELGRIRS 1957
Query: 466 MQEVHIKTLEEIKLEKALRVQQSSESSTSSPSQHEATPGARRLLRITKRTGMKEEKNLQE 525
E +++ E+ +LE A + Q ++E + EA ++ L + + + L+E
Sbjct: 1958 NAEDTLRSKEQAELEAARQRQLAAEEERR---RREAEERVQKSLAAEEEAARQRKAALEE 2014
Query: 526 GN----EVDSQSSIRTEAKEASGETTGVDITKIQVKRCETMREKH----MQKQQE----- 572
+V+ +R A++ S + Q KR + + H QK+QE
Sbjct: 2015 VERLKAKVEEARRLRERAEQESARQLQLAQEAAQ-KRLQAEEKAHAFAVQQKEQELQQTL 2073
Query: 573 -REKSVLTPLRGDVASCNTQVAEKPVLTAVPGITRHLTKRLPTKSSQKVEVETSGIGDSL 631
+E+SVL LRG+ A + AE+ V R + +++++ +
Sbjct: 2074 QQEQSVLDQLRGE-AEAARRAAEEAEEARVQAEREAAQSRRQVEEAERLKQSAEEQAQAR 2132
Query: 632 LNVKCAAQTLEKRGK 646
+ AA+ L K +
Sbjct: 2133 AQAQAAAEKLRKEAE 2147
Score = 38.5 bits (88), Expect = 0.025
Identities = 66/335 (19%), Positives = 136/335 (40%), Gaps = 53/335 (15%)
Query: 304 AQRLGKKVEAPETNIDKTPKKAQVSKSLKERLGMSADPDNE-----DATDKVNKVGEIHV 358
A+RL ++V+ D++ +K Q L R+ A+ E A +++ E
Sbjct: 1500 AERLRRQVQ------DESQRKRQAEVELASRVKAEAEAAREKQRALQALEELRLQAEEAE 1553
Query: 359 KTLEEILLERASQKRGELQTKLKTEGPSKTDDSTSGARSSSTIRIKTFSEVLAEKKHRQQ 418
+ L + +ERA Q + L+T A+ S+ +++ AEK
Sbjct: 1554 RRLRQAEVERARQVQVALET----------------AQRSAEAELQSKRASFAEKT---A 1594
Query: 419 EAERQKSKKDTTCIKLKIDSEIKKTVVLPPIVASRGQSEEPAGKTKSMQEVHIKTLEEIK 478
+ ER ++ +L+ ++E R Q + A + + E ++ + +K
Sbjct: 1595 QLERSLQEEHVAVAQLREEAE------------RRAQQQAEAERAREEAERELERWQ-LK 1641
Query: 479 LEKALRVQQSSE--SSTSSPSQHEATPGARRLLRITKRTGMKEEKNLQEGNEVDSQSSIR 536
+ALR++ +E + S +Q EA R +R G EE+ +++ + + +
Sbjct: 1642 ANEALRLRLQAEEVAQQKSLAQAEAEKQKEEAEREARRRGKAEEQAVRQRELAEQELEKQ 1701
Query: 537 TEAKEASGETTGVDITKIQVKRCETMREKHMQK-------QQEREKSVLTPLRGDVASCN 589
+ E + + ++ R ET + + ++ + +RE + T R ++ +
Sbjct: 1702 RQLAEGTAQQRLAAEQELIRLRAETEQGEQQRQLLEEELARLQREAAAATQKRQELEAEL 1761
Query: 590 TQV-AEKPVLTAVPGITRHLTKRLPTKSSQKVEVE 623
+V AE VL A ++ KS Q++E E
Sbjct: 1762 AKVRAEMEVLLASKARAEEESRSTSEKSKQRLEAE 1796
>gi|41322919 plectin 1 isoform 8 [Homo sapiens]
Length = 4547
Score = 48.1 bits (113), Expect = 3e-05
Identities = 79/375 (21%), Positives = 151/375 (40%), Gaps = 39/375 (10%)
Query: 301 RSLAQRLGKKVEAPETNIDKTPKKAQVSKSLKERLGMSADPDNEDAT-----------DK 349
RS +++ +++EA + ++A ++L E EDA +K
Sbjct: 1779 RSTSEKSKQRLEAEAGRFRELAEEAARLRALAEEAKRQRQLAEEDAARQRAEAERVLAEK 1838
Query: 350 VNKVGEI-HVKTLEEILLERASQKRGELQTKLKTEGPSKTDDSTSGARSSSTIRIKTFSE 408
+ +GE +KT EI L+ + L+ + E + A+ + I E
Sbjct: 1839 LAAIGEATRLKTEAEIALKEKEAENERLRRLAEDEAFQRRRLEEQAAQHKADIE-----E 1893
Query: 409 VLAE-KKHRQQEAERQKSK-KDTTCIKLKIDSEIKKTVV-LPPIVASRGQSEEPAGKTKS 465
LA+ +K E ERQK +DT + +++ EI A + + E G+ +S
Sbjct: 1894 RLAQLRKASDSELERQKGLVEDTLRQRRQVEEEILALKASFEKAAAGKAELELELGRIRS 1953
Query: 466 MQEVHIKTLEEIKLEKALRVQQSSESSTSSPSQHEATPGARRLLRITKRTGMKEEKNLQE 525
E +++ E+ +LE A + Q ++E + EA ++ L + + + L+E
Sbjct: 1954 NAEDTLRSKEQAELEAARQRQLAAEEERR---RREAEERVQKSLAAEEEAARQRKAALEE 2010
Query: 526 GN----EVDSQSSIRTEAKEASGETTGVDITKIQVKRCETMREKH----MQKQQE----- 572
+V+ +R A++ S + Q KR + + H QK+QE
Sbjct: 2011 VERLKAKVEEARRLRERAEQESARQLQLAQEAAQ-KRLQAEEKAHAFAVQQKEQELQQTL 2069
Query: 573 -REKSVLTPLRGDVASCNTQVAEKPVLTAVPGITRHLTKRLPTKSSQKVEVETSGIGDSL 631
+E+SVL LRG+ A + AE+ V R + +++++ +
Sbjct: 2070 QQEQSVLDQLRGE-AEAARRAAEEAEEARVQAEREAAQSRRQVEEAERLKQSAEEQAQAR 2128
Query: 632 LNVKCAAQTLEKRGK 646
+ AA+ L K +
Sbjct: 2129 AQAQAAAEKLRKEAE 2143
Score = 38.5 bits (88), Expect = 0.025
Identities = 66/335 (19%), Positives = 136/335 (40%), Gaps = 53/335 (15%)
Query: 304 AQRLGKKVEAPETNIDKTPKKAQVSKSLKERLGMSADPDNE-----DATDKVNKVGEIHV 358
A+RL ++V+ D++ +K Q L R+ A+ E A +++ E
Sbjct: 1496 AERLRRQVQ------DESQRKRQAEVELASRVKAEAEAAREKQRALQALEELRLQAEEAE 1549
Query: 359 KTLEEILLERASQKRGELQTKLKTEGPSKTDDSTSGARSSSTIRIKTFSEVLAEKKHRQQ 418
+ L + +ERA Q + L+T A+ S+ +++ AEK
Sbjct: 1550 RRLRQAEVERARQVQVALET----------------AQRSAEAELQSKRASFAEKT---A 1590
Query: 419 EAERQKSKKDTTCIKLKIDSEIKKTVVLPPIVASRGQSEEPAGKTKSMQEVHIKTLEEIK 478
+ ER ++ +L+ ++E R Q + A + + E ++ + +K
Sbjct: 1591 QLERSLQEEHVAVAQLREEAE------------RRAQQQAEAERAREEAERELERWQ-LK 1637
Query: 479 LEKALRVQQSSE--SSTSSPSQHEATPGARRLLRITKRTGMKEEKNLQEGNEVDSQSSIR 536
+ALR++ +E + S +Q EA R +R G EE+ +++ + + +
Sbjct: 1638 ANEALRLRLQAEEVAQQKSLAQAEAEKQKEEAEREARRRGKAEEQAVRQRELAEQELEKQ 1697
Query: 537 TEAKEASGETTGVDITKIQVKRCETMREKHMQK-------QQEREKSVLTPLRGDVASCN 589
+ E + + ++ R ET + + ++ + +RE + T R ++ +
Sbjct: 1698 RQLAEGTAQQRLAAEQELIRLRAETEQGEQQRQLLEEELARLQREAAAATQKRQELEAEL 1757
Query: 590 TQV-AEKPVLTAVPGITRHLTKRLPTKSSQKVEVE 623
+V AE VL A ++ KS Q++E E
Sbjct: 1758 AKVRAEMEVLLASKARAEEESRSTSEKSKQRLEAE 1792
>gi|41322910 plectin 1 isoform 7 [Homo sapiens]
Length = 4515
Score = 48.1 bits (113), Expect = 3e-05
Identities = 79/375 (21%), Positives = 151/375 (40%), Gaps = 39/375 (10%)
Query: 301 RSLAQRLGKKVEAPETNIDKTPKKAQVSKSLKERLGMSADPDNEDAT-----------DK 349
RS +++ +++EA + ++A ++L E EDA +K
Sbjct: 1747 RSTSEKSKQRLEAEAGRFRELAEEAARLRALAEEAKRQRQLAEEDAARQRAEAERVLAEK 1806
Query: 350 VNKVGEI-HVKTLEEILLERASQKRGELQTKLKTEGPSKTDDSTSGARSSSTIRIKTFSE 408
+ +GE +KT EI L+ + L+ + E + A+ + I E
Sbjct: 1807 LAAIGEATRLKTEAEIALKEKEAENERLRRLAEDEAFQRRRLEEQAAQHKADIE-----E 1861
Query: 409 VLAE-KKHRQQEAERQKSK-KDTTCIKLKIDSEIKKTVV-LPPIVASRGQSEEPAGKTKS 465
LA+ +K E ERQK +DT + +++ EI A + + E G+ +S
Sbjct: 1862 RLAQLRKASDSELERQKGLVEDTLRQRRQVEEEILALKASFEKAAAGKAELELELGRIRS 1921
Query: 466 MQEVHIKTLEEIKLEKALRVQQSSESSTSSPSQHEATPGARRLLRITKRTGMKEEKNLQE 525
E +++ E+ +LE A + Q ++E + EA ++ L + + + L+E
Sbjct: 1922 NAEDTLRSKEQAELEAARQRQLAAEEERR---RREAEERVQKSLAAEEEAARQRKAALEE 1978
Query: 526 GN----EVDSQSSIRTEAKEASGETTGVDITKIQVKRCETMREKH----MQKQQE----- 572
+V+ +R A++ S + Q KR + + H QK+QE
Sbjct: 1979 VERLKAKVEEARRLRERAEQESARQLQLAQEAAQ-KRLQAEEKAHAFAVQQKEQELQQTL 2037
Query: 573 -REKSVLTPLRGDVASCNTQVAEKPVLTAVPGITRHLTKRLPTKSSQKVEVETSGIGDSL 631
+E+SVL LRG+ A + AE+ V R + +++++ +
Sbjct: 2038 QQEQSVLDQLRGE-AEAARRAAEEAEEARVQAEREAAQSRRQVEEAERLKQSAEEQAQAR 2096
Query: 632 LNVKCAAQTLEKRGK 646
+ AA+ L K +
Sbjct: 2097 AQAQAAAEKLRKEAE 2111
Score = 38.5 bits (88), Expect = 0.025
Identities = 66/335 (19%), Positives = 136/335 (40%), Gaps = 53/335 (15%)
Query: 304 AQRLGKKVEAPETNIDKTPKKAQVSKSLKERLGMSADPDNE-----DATDKVNKVGEIHV 358
A+RL ++V+ D++ +K Q L R+ A+ E A +++ E
Sbjct: 1464 AERLRRQVQ------DESQRKRQAEVELASRVKAEAEAAREKQRALQALEELRLQAEEAE 1517
Query: 359 KTLEEILLERASQKRGELQTKLKTEGPSKTDDSTSGARSSSTIRIKTFSEVLAEKKHRQQ 418
+ L + +ERA Q + L+T A+ S+ +++ AEK
Sbjct: 1518 RRLRQAEVERARQVQVALET----------------AQRSAEAELQSKRASFAEKT---A 1558
Query: 419 EAERQKSKKDTTCIKLKIDSEIKKTVVLPPIVASRGQSEEPAGKTKSMQEVHIKTLEEIK 478
+ ER ++ +L+ ++E R Q + A + + E ++ + +K
Sbjct: 1559 QLERSLQEEHVAVAQLREEAE------------RRAQQQAEAERAREEAERELERWQ-LK 1605
Query: 479 LEKALRVQQSSE--SSTSSPSQHEATPGARRLLRITKRTGMKEEKNLQEGNEVDSQSSIR 536
+ALR++ +E + S +Q EA R +R G EE+ +++ + + +
Sbjct: 1606 ANEALRLRLQAEEVAQQKSLAQAEAEKQKEEAEREARRRGKAEEQAVRQRELAEQELEKQ 1665
Query: 537 TEAKEASGETTGVDITKIQVKRCETMREKHMQK-------QQEREKSVLTPLRGDVASCN 589
+ E + + ++ R ET + + ++ + +RE + T R ++ +
Sbjct: 1666 RQLAEGTAQQRLAAEQELIRLRAETEQGEQQRQLLEEELARLQREAAAATQKRQELEAEL 1725
Query: 590 TQV-AEKPVLTAVPGITRHLTKRLPTKSSQKVEVE 623
+V AE VL A ++ KS Q++E E
Sbjct: 1726 AKVRAEMEVLLASKARAEEESRSTSEKSKQRLEAE 1760
>gi|41322916 plectin 1 isoform 6 [Homo sapiens]
Length = 4684
Score = 48.1 bits (113), Expect = 3e-05
Identities = 79/375 (21%), Positives = 151/375 (40%), Gaps = 39/375 (10%)
Query: 301 RSLAQRLGKKVEAPETNIDKTPKKAQVSKSLKERLGMSADPDNEDAT-----------DK 349
RS +++ +++EA + ++A ++L E EDA +K
Sbjct: 1916 RSTSEKSKQRLEAEAGRFRELAEEAARLRALAEEAKRQRQLAEEDAARQRAEAERVLAEK 1975
Query: 350 VNKVGEI-HVKTLEEILLERASQKRGELQTKLKTEGPSKTDDSTSGARSSSTIRIKTFSE 408
+ +GE +KT EI L+ + L+ + E + A+ + I E
Sbjct: 1976 LAAIGEATRLKTEAEIALKEKEAENERLRRLAEDEAFQRRRLEEQAAQHKADIE-----E 2030
Query: 409 VLAE-KKHRQQEAERQKSK-KDTTCIKLKIDSEIKKTVV-LPPIVASRGQSEEPAGKTKS 465
LA+ +K E ERQK +DT + +++ EI A + + E G+ +S
Sbjct: 2031 RLAQLRKASDSELERQKGLVEDTLRQRRQVEEEILALKASFEKAAAGKAELELELGRIRS 2090
Query: 466 MQEVHIKTLEEIKLEKALRVQQSSESSTSSPSQHEATPGARRLLRITKRTGMKEEKNLQE 525
E +++ E+ +LE A + Q ++E + EA ++ L + + + L+E
Sbjct: 2091 NAEDTLRSKEQAELEAARQRQLAAEEERR---RREAEERVQKSLAAEEEAARQRKAALEE 2147
Query: 526 GN----EVDSQSSIRTEAKEASGETTGVDITKIQVKRCETMREKH----MQKQQE----- 572
+V+ +R A++ S + Q KR + + H QK+QE
Sbjct: 2148 VERLKAKVEEARRLRERAEQESARQLQLAQEAAQ-KRLQAEEKAHAFAVQQKEQELQQTL 2206
Query: 573 -REKSVLTPLRGDVASCNTQVAEKPVLTAVPGITRHLTKRLPTKSSQKVEVETSGIGDSL 631
+E+SVL LRG+ A + AE+ V R + +++++ +
Sbjct: 2207 QQEQSVLDQLRGE-AEAARRAAEEAEEARVQAEREAAQSRRQVEEAERLKQSAEEQAQAR 2265
Query: 632 LNVKCAAQTLEKRGK 646
+ AA+ L K +
Sbjct: 2266 AQAQAAAEKLRKEAE 2280
Score = 38.5 bits (88), Expect = 0.025
Identities = 66/335 (19%), Positives = 136/335 (40%), Gaps = 53/335 (15%)
Query: 304 AQRLGKKVEAPETNIDKTPKKAQVSKSLKERLGMSADPDNE-----DATDKVNKVGEIHV 358
A+RL ++V+ D++ +K Q L R+ A+ E A +++ E
Sbjct: 1633 AERLRRQVQ------DESQRKRQAEVELASRVKAEAEAAREKQRALQALEELRLQAEEAE 1686
Query: 359 KTLEEILLERASQKRGELQTKLKTEGPSKTDDSTSGARSSSTIRIKTFSEVLAEKKHRQQ 418
+ L + +ERA Q + L+T A+ S+ +++ AEK
Sbjct: 1687 RRLRQAEVERARQVQVALET----------------AQRSAEAELQSKRASFAEKT---A 1727
Query: 419 EAERQKSKKDTTCIKLKIDSEIKKTVVLPPIVASRGQSEEPAGKTKSMQEVHIKTLEEIK 478
+ ER ++ +L+ ++E R Q + A + + E ++ + +K
Sbjct: 1728 QLERSLQEEHVAVAQLREEAE------------RRAQQQAEAERAREEAERELERWQ-LK 1774
Query: 479 LEKALRVQQSSE--SSTSSPSQHEATPGARRLLRITKRTGMKEEKNLQEGNEVDSQSSIR 536
+ALR++ +E + S +Q EA R +R G EE+ +++ + + +
Sbjct: 1775 ANEALRLRLQAEEVAQQKSLAQAEAEKQKEEAEREARRRGKAEEQAVRQRELAEQELEKQ 1834
Query: 537 TEAKEASGETTGVDITKIQVKRCETMREKHMQK-------QQEREKSVLTPLRGDVASCN 589
+ E + + ++ R ET + + ++ + +RE + T R ++ +
Sbjct: 1835 RQLAEGTAQQRLAAEQELIRLRAETEQGEQQRQLLEEELARLQREAAAATQKRQELEAEL 1894
Query: 590 TQV-AEKPVLTAVPGITRHLTKRLPTKSSQKVEVE 623
+V AE VL A ++ KS Q++E E
Sbjct: 1895 AKVRAEMEVLLASKARAEEESRSTSEKSKQRLEAE 1929
>gi|41322908 plectin 1 isoform 3 [Homo sapiens]
Length = 4525
Score = 48.1 bits (113), Expect = 3e-05
Identities = 79/375 (21%), Positives = 151/375 (40%), Gaps = 39/375 (10%)
Query: 301 RSLAQRLGKKVEAPETNIDKTPKKAQVSKSLKERLGMSADPDNEDAT-----------DK 349
RS +++ +++EA + ++A ++L E EDA +K
Sbjct: 1757 RSTSEKSKQRLEAEAGRFRELAEEAARLRALAEEAKRQRQLAEEDAARQRAEAERVLAEK 1816
Query: 350 VNKVGEI-HVKTLEEILLERASQKRGELQTKLKTEGPSKTDDSTSGARSSSTIRIKTFSE 408
+ +GE +KT EI L+ + L+ + E + A+ + I E
Sbjct: 1817 LAAIGEATRLKTEAEIALKEKEAENERLRRLAEDEAFQRRRLEEQAAQHKADIE-----E 1871
Query: 409 VLAE-KKHRQQEAERQKSK-KDTTCIKLKIDSEIKKTVV-LPPIVASRGQSEEPAGKTKS 465
LA+ +K E ERQK +DT + +++ EI A + + E G+ +S
Sbjct: 1872 RLAQLRKASDSELERQKGLVEDTLRQRRQVEEEILALKASFEKAAAGKAELELELGRIRS 1931
Query: 466 MQEVHIKTLEEIKLEKALRVQQSSESSTSSPSQHEATPGARRLLRITKRTGMKEEKNLQE 525
E +++ E+ +LE A + Q ++E + EA ++ L + + + L+E
Sbjct: 1932 NAEDTLRSKEQAELEAARQRQLAAEEERR---RREAEERVQKSLAAEEEAARQRKAALEE 1988
Query: 526 GN----EVDSQSSIRTEAKEASGETTGVDITKIQVKRCETMREKH----MQKQQE----- 572
+V+ +R A++ S + Q KR + + H QK+QE
Sbjct: 1989 VERLKAKVEEARRLRERAEQESARQLQLAQEAAQ-KRLQAEEKAHAFAVQQKEQELQQTL 2047
Query: 573 -REKSVLTPLRGDVASCNTQVAEKPVLTAVPGITRHLTKRLPTKSSQKVEVETSGIGDSL 631
+E+SVL LRG+ A + AE+ V R + +++++ +
Sbjct: 2048 QQEQSVLDQLRGE-AEAARRAAEEAEEARVQAEREAAQSRRQVEEAERLKQSAEEQAQAR 2106
Query: 632 LNVKCAAQTLEKRGK 646
+ AA+ L K +
Sbjct: 2107 AQAQAAAEKLRKEAE 2121
Score = 38.5 bits (88), Expect = 0.025
Identities = 66/335 (19%), Positives = 136/335 (40%), Gaps = 53/335 (15%)
Query: 304 AQRLGKKVEAPETNIDKTPKKAQVSKSLKERLGMSADPDNE-----DATDKVNKVGEIHV 358
A+RL ++V+ D++ +K Q L R+ A+ E A +++ E
Sbjct: 1474 AERLRRQVQ------DESQRKRQAEVELASRVKAEAEAAREKQRALQALEELRLQAEEAE 1527
Query: 359 KTLEEILLERASQKRGELQTKLKTEGPSKTDDSTSGARSSSTIRIKTFSEVLAEKKHRQQ 418
+ L + +ERA Q + L+T A+ S+ +++ AEK
Sbjct: 1528 RRLRQAEVERARQVQVALET----------------AQRSAEAELQSKRASFAEKT---A 1568
Query: 419 EAERQKSKKDTTCIKLKIDSEIKKTVVLPPIVASRGQSEEPAGKTKSMQEVHIKTLEEIK 478
+ ER ++ +L+ ++E R Q + A + + E ++ + +K
Sbjct: 1569 QLERSLQEEHVAVAQLREEAE------------RRAQQQAEAERAREEAERELERWQ-LK 1615
Query: 479 LEKALRVQQSSE--SSTSSPSQHEATPGARRLLRITKRTGMKEEKNLQEGNEVDSQSSIR 536
+ALR++ +E + S +Q EA R +R G EE+ +++ + + +
Sbjct: 1616 ANEALRLRLQAEEVAQQKSLAQAEAEKQKEEAEREARRRGKAEEQAVRQRELAEQELEKQ 1675
Query: 537 TEAKEASGETTGVDITKIQVKRCETMREKHMQK-------QQEREKSVLTPLRGDVASCN 589
+ E + + ++ R ET + + ++ + +RE + T R ++ +
Sbjct: 1676 RQLAEGTAQQRLAAEQELIRLRAETEQGEQQRQLLEEELARLQREAAAATQKRQELEAEL 1735
Query: 590 TQV-AEKPVLTAVPGITRHLTKRLPTKSSQKVEVE 623
+V AE VL A ++ KS Q++E E
Sbjct: 1736 AKVRAEMEVLLASKARAEEESRSTSEKSKQRLEAE 1770
>gi|41322912 plectin 1 isoform 2 [Homo sapiens]
Length = 4533
Score = 48.1 bits (113), Expect = 3e-05
Identities = 79/375 (21%), Positives = 151/375 (40%), Gaps = 39/375 (10%)
Query: 301 RSLAQRLGKKVEAPETNIDKTPKKAQVSKSLKERLGMSADPDNEDAT-----------DK 349
RS +++ +++EA + ++A ++L E EDA +K
Sbjct: 1765 RSTSEKSKQRLEAEAGRFRELAEEAARLRALAEEAKRQRQLAEEDAARQRAEAERVLAEK 1824
Query: 350 VNKVGEI-HVKTLEEILLERASQKRGELQTKLKTEGPSKTDDSTSGARSSSTIRIKTFSE 408
+ +GE +KT EI L+ + L+ + E + A+ + I E
Sbjct: 1825 LAAIGEATRLKTEAEIALKEKEAENERLRRLAEDEAFQRRRLEEQAAQHKADIE-----E 1879
Query: 409 VLAE-KKHRQQEAERQKSK-KDTTCIKLKIDSEIKKTVV-LPPIVASRGQSEEPAGKTKS 465
LA+ +K E ERQK +DT + +++ EI A + + E G+ +S
Sbjct: 1880 RLAQLRKASDSELERQKGLVEDTLRQRRQVEEEILALKASFEKAAAGKAELELELGRIRS 1939
Query: 466 MQEVHIKTLEEIKLEKALRVQQSSESSTSSPSQHEATPGARRLLRITKRTGMKEEKNLQE 525
E +++ E+ +LE A + Q ++E + EA ++ L + + + L+E
Sbjct: 1940 NAEDTLRSKEQAELEAARQRQLAAEEERR---RREAEERVQKSLAAEEEAARQRKAALEE 1996
Query: 526 GN----EVDSQSSIRTEAKEASGETTGVDITKIQVKRCETMREKH----MQKQQE----- 572
+V+ +R A++ S + Q KR + + H QK+QE
Sbjct: 1997 VERLKAKVEEARRLRERAEQESARQLQLAQEAAQ-KRLQAEEKAHAFAVQQKEQELQQTL 2055
Query: 573 -REKSVLTPLRGDVASCNTQVAEKPVLTAVPGITRHLTKRLPTKSSQKVEVETSGIGDSL 631
+E+SVL LRG+ A + AE+ V R + +++++ +
Sbjct: 2056 QQEQSVLDQLRGE-AEAARRAAEEAEEARVQAEREAAQSRRQVEEAERLKQSAEEQAQAR 2114
Query: 632 LNVKCAAQTLEKRGK 646
+ AA+ L K +
Sbjct: 2115 AQAQAAAEKLRKEAE 2129
Score = 38.5 bits (88), Expect = 0.025
Identities = 66/335 (19%), Positives = 136/335 (40%), Gaps = 53/335 (15%)
Query: 304 AQRLGKKVEAPETNIDKTPKKAQVSKSLKERLGMSADPDNE-----DATDKVNKVGEIHV 358
A+RL ++V+ D++ +K Q L R+ A+ E A +++ E
Sbjct: 1482 AERLRRQVQ------DESQRKRQAEVELASRVKAEAEAAREKQRALQALEELRLQAEEAE 1535
Query: 359 KTLEEILLERASQKRGELQTKLKTEGPSKTDDSTSGARSSSTIRIKTFSEVLAEKKHRQQ 418
+ L + +ERA Q + L+T A+ S+ +++ AEK
Sbjct: 1536 RRLRQAEVERARQVQVALET----------------AQRSAEAELQSKRASFAEKT---A 1576
Query: 419 EAERQKSKKDTTCIKLKIDSEIKKTVVLPPIVASRGQSEEPAGKTKSMQEVHIKTLEEIK 478
+ ER ++ +L+ ++E R Q + A + + E ++ + +K
Sbjct: 1577 QLERSLQEEHVAVAQLREEAE------------RRAQQQAEAERAREEAERELERWQ-LK 1623
Query: 479 LEKALRVQQSSE--SSTSSPSQHEATPGARRLLRITKRTGMKEEKNLQEGNEVDSQSSIR 536
+ALR++ +E + S +Q EA R +R G EE+ +++ + + +
Sbjct: 1624 ANEALRLRLQAEEVAQQKSLAQAEAEKQKEEAEREARRRGKAEEQAVRQRELAEQELEKQ 1683
Query: 537 TEAKEASGETTGVDITKIQVKRCETMREKHMQK-------QQEREKSVLTPLRGDVASCN 589
+ E + + ++ R ET + + ++ + +RE + T R ++ +
Sbjct: 1684 RQLAEGTAQQRLAAEQELIRLRAETEQGEQQRQLLEEELARLQREAAAATQKRQELEAEL 1743
Query: 590 TQV-AEKPVLTAVPGITRHLTKRLPTKSSQKVEVE 623
+V AE VL A ++ KS Q++E E
Sbjct: 1744 AKVRAEMEVLLASKARAEEESRSTSEKSKQRLEAE 1778
>gi|47607492 plectin 1 isoform 1 [Homo sapiens]
Length = 4574
Score = 48.1 bits (113), Expect = 3e-05
Identities = 79/375 (21%), Positives = 151/375 (40%), Gaps = 39/375 (10%)
Query: 301 RSLAQRLGKKVEAPETNIDKTPKKAQVSKSLKERLGMSADPDNEDAT-----------DK 349
RS +++ +++EA + ++A ++L E EDA +K
Sbjct: 1806 RSTSEKSKQRLEAEAGRFRELAEEAARLRALAEEAKRQRQLAEEDAARQRAEAERVLAEK 1865
Query: 350 VNKVGEI-HVKTLEEILLERASQKRGELQTKLKTEGPSKTDDSTSGARSSSTIRIKTFSE 408
+ +GE +KT EI L+ + L+ + E + A+ + I E
Sbjct: 1866 LAAIGEATRLKTEAEIALKEKEAENERLRRLAEDEAFQRRRLEEQAAQHKADIE-----E 1920
Query: 409 VLAE-KKHRQQEAERQKSK-KDTTCIKLKIDSEIKKTVV-LPPIVASRGQSEEPAGKTKS 465
LA+ +K E ERQK +DT + +++ EI A + + E G+ +S
Sbjct: 1921 RLAQLRKASDSELERQKGLVEDTLRQRRQVEEEILALKASFEKAAAGKAELELELGRIRS 1980
Query: 466 MQEVHIKTLEEIKLEKALRVQQSSESSTSSPSQHEATPGARRLLRITKRTGMKEEKNLQE 525
E +++ E+ +LE A + Q ++E + EA ++ L + + + L+E
Sbjct: 1981 NAEDTLRSKEQAELEAARQRQLAAEEERR---RREAEERVQKSLAAEEEAARQRKAALEE 2037
Query: 526 GN----EVDSQSSIRTEAKEASGETTGVDITKIQVKRCETMREKH----MQKQQE----- 572
+V+ +R A++ S + Q KR + + H QK+QE
Sbjct: 2038 VERLKAKVEEARRLRERAEQESARQLQLAQEAAQ-KRLQAEEKAHAFAVQQKEQELQQTL 2096
Query: 573 -REKSVLTPLRGDVASCNTQVAEKPVLTAVPGITRHLTKRLPTKSSQKVEVETSGIGDSL 631
+E+SVL LRG+ A + AE+ V R + +++++ +
Sbjct: 2097 QQEQSVLDQLRGE-AEAARRAAEEAEEARVQAEREAAQSRRQVEEAERLKQSAEEQAQAR 2155
Query: 632 LNVKCAAQTLEKRGK 646
+ AA+ L K +
Sbjct: 2156 AQAQAAAEKLRKEAE 2170
Score = 38.5 bits (88), Expect = 0.025
Identities = 66/335 (19%), Positives = 136/335 (40%), Gaps = 53/335 (15%)
Query: 304 AQRLGKKVEAPETNIDKTPKKAQVSKSLKERLGMSADPDNE-----DATDKVNKVGEIHV 358
A+RL ++V+ D++ +K Q L R+ A+ E A +++ E
Sbjct: 1523 AERLRRQVQ------DESQRKRQAEVELASRVKAEAEAAREKQRALQALEELRLQAEEAE 1576
Query: 359 KTLEEILLERASQKRGELQTKLKTEGPSKTDDSTSGARSSSTIRIKTFSEVLAEKKHRQQ 418
+ L + +ERA Q + L+T A+ S+ +++ AEK
Sbjct: 1577 RRLRQAEVERARQVQVALET----------------AQRSAEAELQSKRASFAEKT---A 1617
Query: 419 EAERQKSKKDTTCIKLKIDSEIKKTVVLPPIVASRGQSEEPAGKTKSMQEVHIKTLEEIK 478
+ ER ++ +L+ ++E R Q + A + + E ++ + +K
Sbjct: 1618 QLERSLQEEHVAVAQLREEAE------------RRAQQQAEAERAREEAERELERWQ-LK 1664
Query: 479 LEKALRVQQSSE--SSTSSPSQHEATPGARRLLRITKRTGMKEEKNLQEGNEVDSQSSIR 536
+ALR++ +E + S +Q EA R +R G EE+ +++ + + +
Sbjct: 1665 ANEALRLRLQAEEVAQQKSLAQAEAEKQKEEAEREARRRGKAEEQAVRQRELAEQELEKQ 1724
Query: 537 TEAKEASGETTGVDITKIQVKRCETMREKHMQK-------QQEREKSVLTPLRGDVASCN 589
+ E + + ++ R ET + + ++ + +RE + T R ++ +
Sbjct: 1725 RQLAEGTAQQRLAAEQELIRLRAETEQGEQQRQLLEEELARLQREAAAATQKRQELEAEL 1784
Query: 590 TQV-AEKPVLTAVPGITRHLTKRLPTKSSQKVEVE 623
+V AE VL A ++ KS Q++E E
Sbjct: 1785 AKVRAEMEVLLASKARAEEESRSTSEKSKQRLEAE 1819
>gi|153945790 myosin, heavy chain 8, skeletal muscle, perinatal [Homo
sapiens]
Length = 1937
Score = 47.8 bits (112), Expect = 4e-05
Identities = 100/483 (20%), Positives = 192/483 (39%), Gaps = 60/483 (12%)
Query: 215 KTLEEIKSKKMKEKSKKQGEGSSGVSSLLLHPEPVPGPEKENVRTVVRTVTLSTKQGEEP 274
K LEE +KEK+ Q + S SL E K ++ + ++ + EE
Sbjct: 874 KELEEKMVTLLKEKNDLQLQVQSEADSLADAEERCEQLIKNKIQLEAKIKEVTERAEEEE 933
Query: 275 LVRLSLTERLGKRKFSAGGDSDPPLKRSLAQRLGKKVEAPETNIDKTPKKAQVS----KS 330
+ LT + KRK L K ++ E + K K+ + K+
Sbjct: 934 EINAELTAK--KRKL-----------EDECSELKKDIDDLELTLAKVEKEKHATENKVKN 980
Query: 331 LKERLGMSADPDNEDATDKVNKVGEIHVKTLEEILLERASQKRGELQTKLKTEGPSKTDD 390
L E + D + + + E H +TL+++ +A + + + TK KT+ + DD
Sbjct: 981 LTEEMA-GLDETIAKLSKEKKALQETHQQTLDDL---QAEEDKVNILTKAKTKLEQQVDD 1036
Query: 391 STSGARSSSTIRIKTFSEVLAEKKHRQQEAE---RQKSKKDTTCIKLKIDSEIKKTVVLP 447
+R+ E+ R+ E + Q+S D K ++D +++K
Sbjct: 1037 LEGSLEQEKKLRMD------LERAKRKLEGDLKLAQESTMDMENDKQQLDEKLEKKEFEI 1090
Query: 448 PIVASRGQSEEPA-----GKTKSMQEVHIKTLEEIKLEKALRVQQSSESSTSSPSQHEAT 502
+ S+ + E+ K K +Q + EEI+ E+A R + + S S E
Sbjct: 1091 SNLISKIEDEQAVEIQLQKKIKELQARIEELGEEIEAERASRAKAEKQRSDLSRELEEI- 1149
Query: 503 PGARRLLRITKRTGMKEEKNLQEGNEVDSQSSIRTEAKEASGETTGVDITKIQVKRCETM 562
+ RL T + E N + E +R + +EA+ + + + ++ K ++M
Sbjct: 1150 --SERLEEAGGATSAQVELNKKREAEF---QKLRRDLEEATLQHEAM-VAALRKKHADSM 1203
Query: 563 RE--------KHMQKQQEREKSVLTPLRGDVASCNTQVAEKPVLTAVPGITRHLTKRLPT 614
E + ++++ E+EKS L + D S N + K G + + L
Sbjct: 1204 AELGEQIDNLQRVKQKLEKEKSEL-KMETDDLSSNAEAISK-----AKGNLEKMCRSLED 1257
Query: 615 KSSQ--KVEVETSGIGDSLLNVKCAAQTLEKRGKAKPKVNVKPSVVKVVSSPKLAPKRKA 672
+ S+ E E + + L + QT + G+ +++ K ++V +S K A ++
Sbjct: 1258 QVSELKTKEEEQQRLINDLTAQRARLQT--EAGEYSRQLDEKDALVSQLSRSKQASTQQI 1315
Query: 673 VEM 675
E+
Sbjct: 1316 EEL 1318
Score = 33.1 bits (74), Expect = 1.1
Identities = 56/231 (24%), Positives = 100/231 (43%), Gaps = 48/231 (20%)
Query: 338 SADPDNEDATDKVNKVGEIHVKTLEEILLERASQKRGELQTKLKTEGPSKTD-------- 389
SA+ + E AT K E KT +E L ++ KR EL+ K+ T K D
Sbjct: 845 SAETEKEMATMK-----EEFQKTKDE--LAKSEAKRKELEEKMVTLLKEKNDLQLQVQSE 897
Query: 390 -DSTSGARSSSTIRIKTFSEVLAEKKHRQQEAERQKS-KKDTTCIKLKID---SEIKKTV 444
DS + A IK ++ A+ K + AE ++ + T K K++ SE+KK +
Sbjct: 898 ADSLADAEERCEQLIKNKIQLEAKIKEVTERAEEEEEINAELTAKKRKLEDECSELKKDI 957
Query: 445 VLPPIVASRGQ-------------SEEPAG----------KTKSMQEVHIKTLEEIKLEK 481
+ ++ + +EE AG + K++QE H +TL++++ E+
Sbjct: 958 DDLELTLAKVEKEKHATENKVKNLTEEMAGLDETIAKLSKEKKALQETHQQTLDDLQAEE 1017
Query: 482 ALRVQQSSESSTSSPSQHEATPGA----RRLLRITKRTGMKEEKNLQEGNE 528
+V +++ T Q + G+ ++L +R K E +L+ E
Sbjct: 1018 D-KVNILTKAKTKLEQQVDDLEGSLEQEKKLRMDLERAKRKLEGDLKLAQE 1067
>gi|44680105 caldesmon 1 isoform 1 [Homo sapiens]
Length = 793
Score = 47.4 bits (111), Expect = 5e-05
Identities = 52/271 (19%), Positives = 121/271 (44%), Gaps = 30/271 (11%)
Query: 309 KKVEAPETNIDKTPKKAQVSKSLKERLGMSADPDNEDATDKVNKVGEIHVKTLEEILLER 368
K E+ E + + K Q+S ++ + + E +D+++ H + +EE ER
Sbjct: 215 KTTESQEETVVMSLKNGQISSEEPKQ-----EEEREQGSDEIS-----HHEKMEEEDKER 264
Query: 369 ASQKRGELQTKLKTEGPSKTDDSTSGARSSSTIRIKTFSEVLAEKKHRQQEAERQKSKKD 428
A +R L+ + + ++ D + R+ RI+ + A+++ R++ ER++ +++
Sbjct: 265 AEAERARLEAEERERIKAEQDKKIADERA----RIEAEEKAAAQERERREAEERERMREE 320
Query: 429 TTCI---KLKIDSEIKKTVVLPPIVASRGQSEEPAGKTKSMQEVHIKTLEEIKLEKALRV 485
+ +I E K+ + + + + A + + ++E + EE + R
Sbjct: 321 EKRAAEERQRIKEEEKRAAEERQRI--KEEEKRAAEERQRIKEEEKRAAEE---RQRARA 375
Query: 486 QQSSESSTSSPSQHEATPGARRLLRITKRTGMKEEKNLQEGNEVD----SQSSIRTEAKE 541
++ ++ +++ + ++ TK G K E+ + EG V+ + ++T +
Sbjct: 376 EEEEKAKVEEQKRNKQLEEKKHAMQETKIKGEKVEQKI-EGKWVNEKKAQEDKLQTAVLK 434
Query: 542 ASGETTGVDITKIQVKRCETMREKHMQKQQE 572
GE G TK+Q KR + +K K++E
Sbjct: 435 KQGEEKG---TKVQAKREKLQEDKPTFKKEE 462
Score = 30.8 bits (68), Expect = 5.3
Identities = 61/307 (19%), Positives = 116/307 (37%), Gaps = 50/307 (16%)
Query: 300 KRSLAQRLGKKVEAPETNIDKTPKKAQVSKSLKERLGMSADPDNEDATDKVNKV--GEIH 357
+R+ +RL +K E E ++ + + +V+ ++ PD E T N G+
Sbjct: 43 RRARQERLRQKQE--EESLGQVTDQVEVN-------AQNSVPDEEAKTTTTNTQVEGDDE 93
Query: 358 VKTLEEILL--ERASQKRGELQTKLKTEGPSKTDDSTSGARSSSTIRIKTFSEVLAEKKH 415
LE + ER ++ E + K P+ TD S S S ++ T EK+
Sbjct: 94 AAFLERLARREERRQKRLQEALERQKEFDPTITDASLS--LPSRRMQNDTAENETTEKEE 151
Query: 416 RQQEAERQKSKKDTTCI--------------KLKIDSEIKKTVVLPPIVASRGQSEEPA- 460
+ + + + ++T + K D E ++ P S G+++
Sbjct: 152 KSESRQERYEIEETETVTKSYQKNDWRDAEENKKEDKEKEEEEEEKPKRGSIGENQVEVM 211
Query: 461 ---GKTKSMQEVHIKTLEEIKLEKALRVQQSSESSTSSPSQH---------EATPGARRL 508
T+S +E + +L+ ++ Q+ S H E R
Sbjct: 212 VEEKTTESQEETVVMSLKNGQISSEEPKQEEEREQGSDEISHHEKMEEEDKERAEAERAR 271
Query: 509 LRITKRTGMKEEKNLQEGNEVDSQSSIRTEAKEASGETTGVDITKIQVKRCETMREKHMQ 568
L +R +K E Q+ D ++ I E K A+ E + + + E MRE+ +
Sbjct: 272 LEAEERERIKAE---QDKKIADERARIEAEEKAAAQERE-----RREAEERERMREEEKR 323
Query: 569 KQQEREK 575
+ER++
Sbjct: 324 AAEERQR 330
>gi|89276756 serine/threonine-protein kinase PRP4K [Homo sapiens]
Length = 1007
Score = 47.4 bits (111), Expect = 5e-05
Identities = 70/288 (24%), Positives = 119/288 (41%), Gaps = 39/288 (13%)
Query: 286 KRKFSAGGDSDPPLKRSLAQRLGKKVEAPETNIDK---TPKKAQVSKSL-------KERL 335
K K S+ D D K + K+ E + + DK +P K L K+R
Sbjct: 56 KHKHSSEEDKDKKHKHKHKHKKHKRKEIIDAS-DKEGMSPAKRTKLDDLALLEDLEKQRA 114
Query: 336 GMSADPDNEDATDKVN---------------KVGEIHVKTLE-EILLERASQKRGELQ-- 377
+ A+ DNE KV + GEIH K R+S +G+L+
Sbjct: 115 LIKAELDNELMEGKVQSGMGLILQGYESGSEEEGEIHEKARNGNRSSTRSSSTKGKLELV 174
Query: 378 -TKLKTEGPSKTDDSTSGARSSSTIRIKTFSEVLAEKKHRQQEAERQKSKKDTTCIKLKI 436
K+ T+ SK+ S + K E++ EK R + ER+KSK + K +
Sbjct: 175 DNKITTKKRSKSRSKERTRHRSDKKKSKGGIEIVKEKTTRSKSKERKKSKSPSKRSKSQD 234
Query: 437 DSEIKKTVVLPPIVASRGQSEEPAGKTKSMQEVHIKTLEEIKLEKALRVQQSSESSTSSP 496
+ K+ L R +S+E GK +S + +K ++ K + + +ES +
Sbjct: 235 QARKSKSPTL------RRRSQEKIGKARSPTDDKVKIEDKSKSKDRKKSPIINESRSRDR 288
Query: 497 SQHEATPGARRLLRITKRTGMKEEKNLQEGNEVDSQSS-IRTEAKEAS 543
+ +P R +R+ KE K+ + +E D + I++ +K+AS
Sbjct: 289 GKKSRSPVDLRGKSKDRRSRSKERKS--KRSETDKEKKPIKSPSKDAS 334
Score = 35.0 bits (79), Expect = 0.28
Identities = 78/390 (20%), Positives = 142/390 (36%), Gaps = 51/390 (13%)
Query: 377 QTKLKTEGPSKTDDSTSGARSSSTIRIKTFSEVLAEKKHRQQEAERQKSKKDTTCIKLKI 436
Q +++ K+ + +G S + K + KHR + + + S ++ K K
Sbjct: 12 QPEMEDANSEKSINEENGEVSEDQSQNKHSRHKKKKHKHRSKHKKHKHSSEEDKDKKHKH 71
Query: 437 DSEIKKTVVLPPIVASRGQSEEPAGKTKSMQEVHIKTLEEIKLEKALRVQQSSESSTSSP 496
+ KK I AS + PA +TK + LE+++ ++AL ++ +
Sbjct: 72 KHKHKKHKRKEIIDASDKEGMSPAKRTKLDD---LALLEDLEKQRAL-----IKAELDNE 123
Query: 497 SQHEATPGARRLLRITKRTGMKEEKNLQEGNEVDSQSSIRTEAKEASGETTGVDITKIQV 556
L+ +G +EE + E ++SS T + G+ VD KI
Sbjct: 124 LMEGKVQSGMGLILQGYESGSEEEGEIHEKARNGNRSS--TRSSSTKGKLELVD-NKITT 180
Query: 557 KRCETMREKHMQKQQEREKSVLTPLRGDVASCNTQVAEKPVLTAVPGITRHLTKRLPTKS 616
K+ R K K++ R +S +G + V EK TR +K
Sbjct: 181 KK----RSKSRSKERTRHRSDKKKSKGGIEI----VKEK--------TTRSKSKERKKSK 224
Query: 617 SQKVEVETSGIGDSLLNVKCAAQTLEKRGKAKPKVNVKPSVVKVVSSPKLAPKRKAVEMH 676
S ++ + ++ EK GKA+ + K VK+ K ++K+
Sbjct: 225 SPSKRSKSQDQARKSKSPTLRRRSQEKIGKARSPTDDK---VKIEDKSKSKDRKKS---- 277
Query: 677 AAVIAAVKPLSSSSVLQEPPAKKAAVAVVPLVSEDKSVTVPEAENPRDSLVLPPTQSSSD 736
P+ + S ++ K + + S+D+ E ++ R S +D
Sbjct: 278 --------PIINESRSRDRGKKSRSPVDLRGKSKDRRSRSKERKSKR---------SETD 320
Query: 737 SSPPEVSGPSSSQMSMKTRRLSSASTGKPP 766
+ PS S K R S G+ P
Sbjct: 321 KEKKPIKSPSKDASSGKENRSPSRRPGRSP 350
>gi|5174573 myeloid/lymphoid or mixed-lineage leukemia trithorax
homolog 2 [Homo sapiens]
Length = 1210
Score = 47.0 bits (110), Expect = 7e-05
Identities = 122/628 (19%), Positives = 226/628 (35%), Gaps = 107/628 (17%)
Query: 96 PPSKTVLPTVPESPEEEVKASQLSVQQNKLSVQSNPSPQLRSVMKVESSENVPSPTHPPV 155
PPS + P+ P+S E V ++ S +++ + S+ S
Sbjct: 444 PPSSSAPPSAPQSLPEPVASAHSSSAESESTSDSDSS----------------------- 480
Query: 156 VINAADDDEDDDDQFSEEGDETKTPTLQPTPEVHNGLR----VTSVRKPAV---NIKQGE 208
+D + + SEE + +TP +P P N + +T V +PA + E
Sbjct: 481 ----SDSESESSSSDSEENEPLETPAPEPEPPTTNKWQLDNWLTKVSQPAAPPEGPRSTE 536
Query: 209 CLNFGIKTLEEIKSKKMKEKSKKQGEGSSGVSSLLLHPEPVPGPEKENV------RTVVR 262
++ S +E S+ + S P P P K + + +
Sbjct: 537 PPRRHPESKGSSDSATSQEHSESKDPPPKSSSKAPRAPPEAPHPGKRSCQKSPAQQEPPQ 596
Query: 263 TVTLSTKQGEEPLVRLSLTERLGKRKFSAGGDSDPPL----KRSLAQRLGKKVEA---PE 315
T+ TKQ ++P + + R G R S G+ +P L R + KV+ P
Sbjct: 597 RQTVGTKQPKKP---VKASARAGSRT-SLQGEREPGLLPYGSRDQTSKDKPKVKTKGRPR 652
Query: 316 TNIDKTPKKAQVSKSLKERLGMSADPDNEDATDKVNKVGEIHVKTLEEILLERASQKRGE 375
PK A S K++ S ++ + + +T E L ++ +G
Sbjct: 653 AAASNEPKPAVPPSSEKKKHKSSLPAPSKALSGPEPAKDNVEDRTPEHFALVPLTESQGP 712
Query: 376 LQTKLKTEGPSKTDDSTSGARSSSTIRIKTFSEVLAEKKHRQQEAERQKSKKDTTCIKLK 435
S + TSG R + ++ + + L + + + +K
Sbjct: 713 PH--------SGSGSRTSGCRQAVVVQEDSRKDRLPLPLRDTKLLSPLRDTPPPQSLMVK 764
Query: 436 IDSEIKKTVVLPPIVASRGQSEE----PAGKTKSMQEVHIKTL----------------- 474
I ++ + PP SR + E PAGK S ++ +
Sbjct: 765 ITLDLLSRIPQPPGKGSRQRKAEDKQPPAGKKHSSEKRSSDSSSKLAKKRKGEAERDCDN 824
Query: 475 EEIKLEKALRVQQSSESSTSSPSQHEATPGARRLLRITKRTGMKEEKNLQEGNEVDSQSS 534
++I+LEK ++ Q S SS+SS + T +R + +K+ M + ++ ++ +
Sbjct: 825 KKIRLEKEIKSQ--SSSSSSSHKESSKTKPSRPSSQSSKKE-MLPPPPVSSSSQKPAKPA 881
Query: 535 IRTEAKEASGETTGVD------ITKIQVKRCETMREKHMQKQQEREKSVLTPLRGDVASC 588
++ +EA +T G D TK K +++ ++ + R S GD A+
Sbjct: 882 LKRSRREA--DTCGQDPPKSASSTKSNHKDSSIPKQRRVEGKGSRSSSEHKGSSGDTAN- 938
Query: 589 NTQVAEKPVLTAVPGITR--------HLTKRLPTKSSQKVEVETSGIGDS-------LLN 633
V P + PG + L R K QK E+ T +G + L
Sbjct: 939 PFPVPSLPNGNSKPGKPQVKFDKQQADLHMREAKKMKQKAELMTDRVGKAFKYLEAVLSF 998
Query: 634 VKCAAQTLEKRGKAKPKVNVKPSVVKVV 661
++C T + +K +V V ++
Sbjct: 999 IECGIATESESQSSKSAYSVYSETVDLI 1026
>gi|87299628 biorientation of chromosomes in cell division 1-like
[Homo sapiens]
Length = 3051
Score = 47.0 bits (110), Expect = 7e-05
Identities = 116/608 (19%), Positives = 219/608 (36%), Gaps = 114/608 (18%)
Query: 230 KKQGEGSSGV------SSLLLHPEPVPGPEKENVRTVVRTVTLSTKQGEEPLVRLSLTER 283
K++G G++ +SL+ P PGP + + T +E + TE
Sbjct: 165 KEEGSGNTAPDDEKPDTSLITQGVPTPGPSANVANDAMSILETITSLNQEASAARASTET 224
Query: 284 LGKRKFSAGGDSDPPLKRSLAQRLGKKVEAPETNIDKTPKKAQVSKSLKERLGMSAD--- 340
+ ++R KK+ + T D + K + S+ + ++ +AD
Sbjct: 225 SNAKT---------------SERASKKLPSQPTT-DTSTDKERTSEDMADKEKSTADSGG 268
Query: 341 ------PDNEDATDKVNKVGEIHVKTLEE---ILLER-ASQKRGELQTKLKTEGPSKTDD 390
P +E+ +D V EI T E ILL + Q+ E + K +G K D
Sbjct: 269 EGLETAPKSEEFSDLPCPVEEIKNYTKEHNNLILLNKDVQQESSEQKNKSTDKGEKKPDS 328
Query: 391 STSGARSSS-----------TIRIKTFSEVLAEKKHRQQEAERQKSKKDTTCIKLK---- 435
+ G R + + + +V EK+ +++E E K + K K
Sbjct: 329 NEKGERKKEKKEKTEKKFDHSKKSEDTQKVKDEKQAKEKEVESLKLPSEKNSNKAKTVEG 388
Query: 436 -------IDSEIK-------KTVVLPPIVASRGQSEEPAGKTKSMQEVHIKTLEEIKLEK 481
IDS++ +V + + +EE + SM+E I + +E K ++
Sbjct: 389 TKEDFSLIDSDVDGLTDITVSSVHTSDLSSFEEDTEEEVVTSDSMEEGEITSDDEEKNKQ 448
Query: 482 ALRVQQSSESSTS--------------------SPSQHEATPGARR--LLRITKRTGMKE 519
Q+S+SS S S E T RR + + + ++
Sbjct: 449 NKTKTQTSDSSEGKTKSVRHAYVHKPYLYSKYYSDSDDELTVEQRRQSIAKEKEERLLRR 508
Query: 520 EKNLQEGNEVDSQSSIRTEAKEASGE-TTGVDITKIQVKRCETMREKHMQKQQER---EK 575
+ N ++ E Q + +T++ + G+ + VD+ + K E + + +ER EK
Sbjct: 509 QINREKLEEKRKQKAEKTKSSKTKGQGRSSVDLEESSTKSLEPKAARIKEVLKERKVLEK 568
Query: 576 SVLTPLRGDVASCNTQVAEKPVLTAVPGITRHLTKRLPTKSSQKVEVETSGIGDSLLNVK 635
V + S N + K L K+S+ E E L +V
Sbjct: 569 KVALSKKRKKDSRNVEENSKKKQQYEEDSKETL------KTSEHCEKEKISSSKELKHVH 622
Query: 636 CAAQTLEKRGKAKPKVNVKPSVVKVVSSPKLAPKRKAVEMHAAVIAAV----------KP 685
++ + + ++V V + + KL + K ++ V +
Sbjct: 623 AKSEPSKPARRLSESLHV---VDENKNESKLEREHKRRTSTPVIMEGVQEETDTRDVKRQ 679
Query: 686 LSSSSVLQEPPAKKAAVAVVPLVSEDKSVTVPEAENPRDSLVLPPTQSSSDSSPPEVSGP 745
+ S + E P K+ + + +K + ++E P +L SS P P
Sbjct: 680 VERSEICTEEPQKQKST-----LKNEKHLKKDDSETPHLKSLLKKEVKSSKEKPEREKTP 734
Query: 746 SSSQMSMK 753
S ++S+K
Sbjct: 735 SEDKLSVK 742
Score = 44.3 bits (103), Expect = 5e-04
Identities = 118/553 (21%), Positives = 202/553 (36%), Gaps = 118/553 (21%)
Query: 267 STKQGEEPLVRLSLTERLGKRKFSAGGDSDPPLK-RSLAQRLGKKVEAPETNIDKTPKKA 325
S ++GE + TE+ KF S+ K + Q K+VE+ + +K KA
Sbjct: 328 SNEKGERKKEKKEKTEK----KFDHSKKSEDTQKVKDEKQAKEKEVESLKLPSEKNSNKA 383
Query: 326 QVSKSLKERLGMSADPDNEDATDKVNKVGEIHVKTL-------EEILLERASQKRGEL-- 376
+ + KE + D D + TD V +H L EE ++ S + GE+
Sbjct: 384 KTVEGTKEDFSL-IDSDVDGLTDIT--VSSVHTSDLSSFEEDTEEEVVTSDSMEEGEITS 440
Query: 377 -------QTKLKTEGPSKTDDSTSGAR----------------SSSTIRIKTFSEVLAEK 413
Q K KT+ ++ T R S + ++ + +A++
Sbjct: 441 DDEEKNKQNKTKTQTSDSSEGKTKSVRHAYVHKPYLYSKYYSDSDDELTVEQRRQSIAKE 500
Query: 414 KH----------------RQQEAERQKSKKDTTCIKLKIDSEIKKTVVLPP-------IV 450
K R+Q+AE+ KS K + +D E T L P ++
Sbjct: 501 KEERLLRRQINREKLEEKRKQKAEKTKSSKTKGQGRSSVDLEESSTKSLEPKAARIKEVL 560
Query: 451 ASRGQSEEPAGKTKSMQEVHIKTLEEIKLEKALRVQQSSES-STSSPSQHEATPGARRLL 509
R E+ +K ++ + +EE +K + S E+ TS + E ++ L
Sbjct: 561 KERKVLEKKVALSKKRKK-DSRNVEENSKKKQQYEEDSKETLKTSEHCEKEKISSSKELK 619
Query: 510 RI-TKRTGMKEEKNLQEG----NEVDSQSSIRTEAK---------EASGETTGVDITKIQ 555
+ K K + L E +E ++S + E K E E T K Q
Sbjct: 620 HVHAKSEPSKPARRLSESLHVVDENKNESKLEREHKRRTSTPVIMEGVQEETDTRDVKRQ 679
Query: 556 VKRCE------------TMREKHMQKQQEREKSVLTPLRGDVASCNTQVAEKPVLTAVPG 603
V+R E EKH++K + + L+ +V S EKP
Sbjct: 680 VERSEICTEEPQKQKSTLKNEKHLKKDDSETPHLKSLLKKEVKSSK----EKP------- 728
Query: 604 ITRHLTKRLPTKSSQKVEVETSGIGDSLLNV--KCAAQTLEKRGKAKPKVNVKPSVVKVV 661
+R T S K+ V+ GD + + + EK K + + + K+
Sbjct: 729 ------EREKTPSEDKLSVKHKYKGDCMHKTGDETELHSSEKGLKVEENIQKQSQQTKLS 782
Query: 662 SSPKLAPKRK-AVEMHAAVIAA-VKPLS------SSSVLQEPPAKKAAVAVVPLVSEDKS 713
S K K K E +V+ KP+S +V +E K+ ++ +E KS
Sbjct: 783 SDDKTERKSKHRNERKLSVLGKDGKPVSEYIIKTDENVRKENNKKERRLSAEKTKAEHKS 842
Query: 714 VTVPEAENPRDSL 726
+++ +DSL
Sbjct: 843 RRSSDSKIQKDSL 855
Score = 30.8 bits (68), Expect = 5.3
Identities = 41/163 (25%), Positives = 66/163 (40%), Gaps = 8/163 (4%)
Query: 590 TQVAEKPVLTAVPGITRHLTKRLPTKSSQKVEVETSGIGDSLLNVKCAAQTLEKRGKAKP 649
T+ E P+ +AV G LT + + + TS IG+ +A T++ +P
Sbjct: 2112 TEEFEAPMPSAVSGDDSQLTASRSEEKDECAMISTS-IGEEFELPISSATTIKCAESLQP 2170
Query: 650 KVNVKPSVVKVVSSPKLAPKRKAV-EMHAAVIAAVKPLSSSSVLQEPPAKKAAVAVVPLV 708
V +V + + P L M +A A PL+S+S ++ + ++
Sbjct: 2171 ---VAAAVEERATGPVLISTADFEGPMPSAPPEAESPLASTSKEEKDECALISTSIAEEC 2227
Query: 709 SEDKSVTVPEAENPRDSLVLPPTQSS---SDSSPPEVSGPSSS 748
S V E+EN R V+ S S SS + GP SS
Sbjct: 2228 EASVSGVVVESENERAGTVMEEKDGSGIISTSSVEDCEGPVSS 2270
>gi|125987603 cleavage and polyadenylation specific factor 4, 30kDa
isoform 2 [Homo sapiens]
Length = 244
Score = 47.0 bits (110), Expect = 7e-05
Identities = 29/79 (36%), Positives = 35/79 (44%), Gaps = 7/79 (8%)
Query: 8 CYFFFYSTCTKGDSCPFRHCEAAIGNET-VCTLWQEGRCFR-QVCRFRHMEIDKKRSEIP 65
C FF + C KG CPFRH G +T VC W G C + C F H K E
Sbjct: 41 CEFFLKAACGKGGMCPFRHIS---GEKTVVCKHWLRGLCKKGDQCEFLHEYDMTKMPE-- 95
Query: 66 CYWENQPTGCQKLNCAFHH 84
CY+ ++ C C F H
Sbjct: 96 CYFYSKFGECSNKECPFLH 114
>gi|5729939 cleavage and polyadenylation specific factor 4, 30kDa
isoform 1 [Homo sapiens]
Length = 269
Score = 47.0 bits (110), Expect = 7e-05
Identities = 29/79 (36%), Positives = 35/79 (44%), Gaps = 7/79 (8%)
Query: 8 CYFFFYSTCTKGDSCPFRHCEAAIGNET-VCTLWQEGRCFR-QVCRFRHMEIDKKRSEIP 65
C FF + C KG CPFRH G +T VC W G C + C F H K E
Sbjct: 41 CEFFLKAACGKGGMCPFRHIS---GEKTVVCKHWLRGLCKKGDQCEFLHEYDMTKMPE-- 95
Query: 66 CYWENQPTGCQKLNCAFHH 84
CY+ ++ C C F H
Sbjct: 96 CYFYSKFGECSNKECPFLH 114
>gi|14790190 spen homolog, transcriptional regulator [Homo sapiens]
Length = 3664
Score = 46.6 bits (109), Expect = 9e-05
Identities = 137/735 (18%), Positives = 265/735 (36%), Gaps = 120/735 (16%)
Query: 103 PTVPESPEEEVKASQLSVQQNKLSVQSNPSPQLRSVMKVESSENVPSPTHPPVVINAADD 162
P PES E + ++L + P +V+ +ES+ + T + A
Sbjct: 1617 PKTPESAPEN--------KDSELKTPPSVGPPSVTVVTLESAPSALEKTTGDKTVEAPLV 1668
Query: 163 DEDDDDQFSEEGDETKTPTLQPTPEVHNGLRVTSVRKPAVNIKQGECLNFGIKTLEEIKS 222
E+ + + +E K P +P P L + A K+ + G++
Sbjct: 1669 TEEKTVEPATVSEEAK-PASEPAPAPVEQLEQVDLPPGADPDKEAAMMPAGVE------- 1720
Query: 223 KKMKEKSKKQGEGSSGVSSLLLHPEP-VPG-----------PEKENVRTVVRTVTLSTKQ 270
EGSSG L +P PG PE ++ + + + S +
Sbjct: 1721 -----------EGSSGDQPPYLDAKPPTPGASFSQAESNVDPEPDSTQPLSKPAQKSEEA 1769
Query: 271 GEEPLVRLSLT---ERLGKRKFSAGGDSDPPLKRSLAQRLGKKVEAPETNIDKTPKKAQV 327
E + T E +K A +S PP L +V+ P DK P K++
Sbjct: 1770 NEPKAEKPDATADAEPDANQKAEAAPESQPPASEDL------EVDPPVAAKDKKPNKSKR 1823
Query: 328 SKSLKERLGMSADPDNEDATDKVNKVGEIHVKTLEEILLERASQKRGE----LQTKLKTE 383
SK+ P A V K + ++ L+R++ RGE L+ K++ E
Sbjct: 1824 SKT----------PVQAAAVSIVEKPVTRKSERIDREKLKRSNSPRGEAQKLLELKMEAE 1873
Query: 384 GPSKTDDSTSGARSS--------STIRIKTFSEVLAEKKHRQQEAERQKSKKDTTCIKLK 435
++T S A S R + V A + + ++ + + +
Sbjct: 1874 KITRTASKNSAADLEHPEPSLPLSRTRRRNVRSVYATMGDHENRSPVKEPVEQPRVTRKR 1933
Query: 436 IDSEIKKTVVLPPIVASRGQSEEPAGKTKSMQEVHIKT-LEEIKLEKALRVQQSSESSTS 494
++ E+++ +P RG+ + + +E K E +K + R +S +++
Sbjct: 1934 LERELQEAAAVPT-TPRRGRPPKTRRRADEEEENEAKEPAETLKPPEGWRSPRSQKTAAG 1992
Query: 495 SPSQ-----HEATPGARRLLRITK---RTGMKEEKNLQEGNEVDSQSSIRTEAKEASGET 546
Q +E A R T+ + G+KE + E ++ S + + K+A +
Sbjct: 1993 GGPQGKKGKNEPKVDATRPEATTEVGPQIGVKESSMEPKAAEEEAGSEQKRDRKDAGTDK 2052
Query: 547 TGVDITKIQVKRCETMREKHMQKQQEREK----------------SVLTPLRGDVASCNT 590
+ ++V + EK+ + ++ R + + ++P RG A
Sbjct: 2053 NPPETAPVEVVEKKPAPEKNSKSKRGRSRNSRLAVDKSASLKNVDAAVSP-RGAAAQAGE 2111
Query: 591 Q----VAEKPVLTAVPGITRHLTKRL------PTKSSQKVEVETSGIGDSL------LNV 634
+ VA P + P L+ +L P K +K +V SG + +
Sbjct: 2112 RESGVVAVSPEKSESPQKEDGLSSQLKSDPVDPDKEPEKEDVSASGPSPEATQLAKQMEL 2171
Query: 635 KCAAQTLEKRGKAKPKVNVK---PSVVKVVSSPKLAPKRKAVEMHAAVIAAVKPLSS--S 689
+ A + + K +A K P + K A + E+ AA+ + + +S
Sbjct: 2172 EQAVEHIAKLAEASASAAYKADAPEGLAPEDRDKPAHQASETELAAAIGSIINDISGEPE 2231
Query: 690 SVLQEPPAKKAAVAVVPLVSEDKSVTVPEAENPRDSLV--LPPTQSSSDSSPPEVSGPSS 747
+ PP + + + +++ E D V + T+++++SS P V+ P
Sbjct: 2232 NFPAPPPYPGESQTDLQPPAGAQALQPSEEGMETDEAVSGILETEAATESSRPPVNAPDP 2291
Query: 748 SQMSMKTRRLSSAST 762
S T+ S+
Sbjct: 2292 SAGPTDTKEARGNSS 2306
Score = 42.0 bits (97), Expect = 0.002
Identities = 91/446 (20%), Positives = 171/446 (38%), Gaps = 79/446 (17%)
Query: 179 TPTLQPTPEVHNGLRVTSVRKPAVNIKQGECLNFGIKTLEEIKSKKMKEKSKK------Q 232
TP + ++ N +S + + Q E + LE ++ K KEK +
Sbjct: 894 TPVEKLKAKLDNDTVKSSALDQKLQVSQTEPAKSDLSKLESVRMKVPKEKGLSSHVEVVE 953
Query: 233 GEGSSGVSSLLLHPEPVPGP---EKENVRTVVRTVTLSTKQGEE--PLVRLSLTERLGKR 287
EG L +P G + E + R S + E+ P V+ S E R
Sbjct: 954 KEGRLKARKHLKPEQPADGVSAVDLEKLEARKRRFADSNLKAEKQKPEVKKSSPEMEDAR 1013
Query: 288 KFSA---------------GGDSDPPLKRSLAQRLGKKVEAPETNIDKTPKKAQVSKSLK 332
S G P+++ + +R KK++ N +PK Q
Sbjct: 1014 VLSKKQPDVSSREVILLREGEAERKPVRKEILKRESKKIKLDRLNTVASPKDCQ------ 1067
Query: 333 ERLGMSADPDNEDATDKVNKVGEIHVKTLE--EILLERASQKRGELQ--TKLKTEGPSKT 388
E +S + ++D ++GE+ +++E E+ ++ + +L+ L +GP +
Sbjct: 1068 ELASISVGSGSRPSSDLQARLGELAGESVENQEVQSKKPIPSKPQLKQLQVLDDQGPERE 1127
Query: 389 D-------------DSTSGARSSSTI-----------RIKTFSEVLAEKKHRQQ-EAERQ 423
D + SG S ++ +++ + + + + +QQ E E
Sbjct: 1128 DVRKNYCSLRDETPERKSGQEKSHSVNTEEKIGIDIDHTQSYRKQMEQSRRKQQMEMEIA 1187
Query: 424 KSKKDTTCIKLKIDSEIKKTVV----LPPIVASRGQSEEPAGKTKSMQEV--HIKTLEEI 477
KS+K + K +D ++++V PP + + P K K M V I T E
Sbjct: 1188 KSEKFGS-PKKDVDEYERRSLVHEVGKPPQDVT---DDSPPSKKKRMDHVDFDICTKRER 1243
Query: 478 KLEKALRVQQSSESSTSSPS-------QHEATPGARRLLRITKRTGMKEEKNLQEGNEVD 530
+ ++ + SE + SPS + E G+ RLL + K + +EK L N
Sbjct: 1244 NYRSSRQISEDSERTGGSPSVRHGSFHEDEDPIGSPRLLSV-KGSPKVDEKVLPYSNITV 1302
Query: 531 SQSSIRTEAKEASGETTGVDITKIQV 556
+ S++ ++S D+ KI++
Sbjct: 1303 REESLKFNPYDSSRREQMADMAKIKL 1328
Score = 36.6 bits (83), Expect = 0.096
Identities = 102/512 (19%), Positives = 197/512 (38%), Gaps = 81/512 (15%)
Query: 320 KTPKKAQVSKSLKERLGMSAD----PDNEDATDKVNKVGEIHVKTLEEILLERASQKRGE 375
+ P+ S S ERL ++ + D + + + + L++ LER + + E
Sbjct: 732 RRPQSPGASPSQAERLPSDSERRLYSRSSDRSGSCSSLSPPRYEKLDKSRLERYT--KNE 789
Query: 376 LQTKLKTEGPSKTDDSTSGARSSSTIRIKTFSEVLAEKKHR--------QQEAERQKS-K 426
K +T P + + R + KT + K H QE ER++S +
Sbjct: 790 KTDKERTFDPERVERERRLIRKEKVEKDKTDKQKRKGKVHSPSSQSSETDQENEREQSPE 849
Query: 427 KDTTCIKLKIDSEIKKTV------VLPPIVASRGQSEE-------PAGKTKSMQEVHIKT 473
K +C KL + K+ + ++P +V +R + +E P K K+ ++ T
Sbjct: 850 KPRSCNKLSREKADKEGIAKNRLELMPCVVLTRVKEKEGKVIDHTPVEKLKA--KLDNDT 907
Query: 474 LEEIKLEKALRVQQSSESSTSSPSQHEAT-------PGARRLLRITKRTG-MKEEKNLQE 525
++ L++ L+V Q+ E + S S+ E+ G + + ++ G +K K+L+
Sbjct: 908 VKSSALDQKLQVSQT-EPAKSDLSKLESVRMKVPKEKGLSSHVEVVEKEGRLKARKHLKP 966
Query: 526 GNEVDSQSSIRTEAKEASGETTGVDITKIQVKRCETMREKHMQKQQEREKSVLTPLRGDV 585
D S++ E EA K + ++ E + + + VL+ + DV
Sbjct: 967 EQPADGVSAVDLEKLEARKRRFADSNLKAEKQKPEVKKSS----PEMEDARVLSKKQPDV 1022
Query: 586 ASCNT------QVAEKPVLTAVPGITRHLTK----RLPTKSSQK-------VEVETSGIG 628
+S + KPV + + R K RL T +S K + V +
Sbjct: 1023 SSREVILLREGEAERKPVRKEI--LKRESKKIKLDRLNTVASPKDCQELASISVGSGSRP 1080
Query: 629 DSLLNVKC---AAQTLEKRG-KAKPKVNVKPSVVKVVSSPKLAPKRKAVEMHAAVIAAVK 684
S L + A +++E + ++K + KP + ++ P+R+ V +
Sbjct: 1081 SSDLQARLGELAGESVENQEVQSKKPIPSKPQLKQLQVLDDQGPEREDVRKNYC------ 1134
Query: 685 PLSSSSVLQEPPAKKAAVAVVPLVSEDKSV--TVPEAENPRDSLVLP--PTQSSSDSSPP 740
S+ E P +K+ V+ ++ + + ++ R + Q + +
Sbjct: 1135 -----SLRDETPERKSGQEKSHSVNTEEKIGIDIDHTQSYRKQMEQSRRKQQMEMEIAKS 1189
Query: 741 EVSGPSSSQMSMKTRRLSSASTGKPPLSVEDD 772
E G + RR GKPP V DD
Sbjct: 1190 EKFGSPKKDVDEYERRSLVHEVGKPPQDVTDD 1221
>gi|207113162 Treacher Collins-Franceschetti syndrome 1 isoform e
[Homo sapiens]
Length = 1451
Score = 46.6 bits (109), Expect = 9e-05
Identities = 132/626 (21%), Positives = 212/626 (33%), Gaps = 100/626 (15%)
Query: 163 DEDDDDQFSEEGDETKTPTLQPTPEVHNGLRVTSVRKPAVNIKQGECLNFGIKTLEEIKS 222
D + SEE +E + T + TP + + N + + S
Sbjct: 80 DPISTSESSEEEEEAEAETAKATPRLAS-------------------TNSSVLGADLPSS 120
Query: 223 KKMKEKSKKQGEGSSGVSSLLLHPEPVPGPEKENVRTVVRTVTLSTKQGEEPLVRLSL-T 281
K K K++ + G +G S P P G N+ + S ++ EP +L +
Sbjct: 121 MKEKAKAETEKAGKTGNSM----PHPATGKTVANLLS-----GKSPRKSAEPSANTTLVS 171
Query: 282 ERLGKRKFSAGGDSDPPLKRSLAQRLGKKVE----APETNIDKTP--KKAQV---SKSLK 332
E + A G + P S Q + + ET+++ P K AQV S S K
Sbjct: 172 ETEEEGSVPAFGAAAKPGMVSAGQADSSSEDTSSSSDETDVEGKPSVKPAQVKASSVSTK 231
Query: 333 ERLGMSADPDNEDATDKVNKVGEIHVKTLEEILLERASQKRGELQTKLKTEGPSKTDDST 392
E A P KVG++ + L K+ E +++ EG +++
Sbjct: 232 ESPARKAAP-------APGKVGDVTPQVKGGALPPAKRAKKPEEESESSEEGSESEEEAP 284
Query: 393 SGARSSSTIRIKTFSEVLAEKKHRQQEAERQKSKKDTTCIKLKIDSEIKKTVVLPPIVAS 452
+G RS +V A +K Q A +K + K PP A
Sbjct: 285 AGTRS----------QVKASEKILQVRAASAPAK----------GTPGKGATPAPPGKAG 324
Query: 453 RGQSEEPAGKTKSMQEVHIKTLEEIKLEKALRVQQSSESSTSSPSQHEATPGARRLLRIT 512
S+ AGK + + S SS S E TP A+ LL+
Sbjct: 325 AVASQTKAGKPE---------------------EDSESSSEESSDSEEETPAAKALLQ-A 362
Query: 513 KRTGMKEEKNLQEGN-EVDSQSSIRTEAKEASGETTGVDITKIQV-KRCETMREKHMQKQ 570
K +G K Q G ++ S R A A TG + K Q KR E + +
Sbjct: 363 KASG----KTSQVGAASAPAKESPRKGAAPAPPGKTGPAVAKAQAGKREEDSQSSSEESD 418
Query: 571 QEREKSVLTPLRG---DVASCNTQVAEKPVLTAVPGITRHLTKRLPTKSSQKVEVETSGI 627
E E G V + + E P A P R K P + +V +
Sbjct: 419 SEEEAPAQAKPSGKAPQVRAASAPAKESPRKGAAPAPPR---KTGPAAAQVQVGKQEEDS 475
Query: 628 GDSLLNVKCAAQTLEKRGKAKPKVNVKPSVVKVVSSPKLAPKRK-AVEMHAAVIAAVKPL 686
S + L A+ K K VK S+ + P K A + + P
Sbjct: 476 RSSSEESDSDREALAAMNAAQVKPLGKSPQVKPASTMGMGPLGKGAGPVPPGKVGPATPS 535
Query: 687 SSSSVLQEPPAKKAAVAVVPLVSEDKSVTVPEAENPRDSLVLPPTQSSSDSSPPEVSGPS 746
+ +E + + E + P E +++ SS PP+ +GP
Sbjct: 536 AQVGKWEEDSESSSEESSDSSDGEVPTAVAPAQEKSLGNILQAKPTSSPAKGPPQKAGPV 595
Query: 747 SSQMSMKTRRLSSASTGKPPLSVEDD 772
+ Q+ + +S S+ + S + +
Sbjct: 596 AVQVKAEKPMDNSESSEESSDSADSE 621
Score = 34.7 bits (78), Expect = 0.36
Identities = 74/395 (18%), Positives = 143/395 (36%), Gaps = 55/395 (13%)
Query: 410 LAEKKHRQQEAERQKSKKDTTCIKLKIDSEIKKTVVLPPIVASRGQSEEPAGKTKSMQEV 469
+ + K A+ K +++K + + + S E PA T + +
Sbjct: 575 ILQAKPTSSPAKGPPQKAGPVAVQVKAEKPMDNSESSEESSDSADSEEAPAAMTAAQAKP 634
Query: 470 HIKTLEEIKLEKALRVQQSSESSTSSPSQHEATPGARRLLRITKRTGMKEEKNLQEGNEV 529
+K I KA + ++ +S T R+ T G + G +
Sbjct: 635 ALK----IPQTKACPKKTNTTASAKVAPVRVGTQAPRKAGTATSPAGSSPA--VAGGTQR 688
Query: 530 DSQSSIRTEAKEASGETTGVDITKIQVKRCETMREKHMQKQQEREKSVLTPLRGDVASCN 589
++ S +E ++ E TG+ +T Q K K +Q K+ P++G +
Sbjct: 689 PAEDSSSSEESDSEEEKTGLAVTVGQAKSVG----KGLQV-----KAASVPVKGSLGQ-- 737
Query: 590 TQVAEKPVLTAVPGITRHLTKRLPTKSSQKVEVETSGIGDSLLNVKCAAQTLEKRGKAKP 649
PVL G T K + S+ E E+ + + + + KA P
Sbjct: 738 ---GTAPVLPGKTGPTVTQVKAEKQEDSESSEEESDSEEAAASPAQVKTSVKKTQAKANP 794
Query: 650 KVNVKPSVVKVVSSP----------------KLAPKRKAVEMH-------AAVIAAVKPL 686
PS +S+P K+ P + + A+V + K +
Sbjct: 795 AAARAPSAKGTISAPGKVVTAAAQAKQRSPSKVKPPVRNPQNSTVLARGPASVPSVGKAV 854
Query: 687 SSSSVLQEPPAKKAAVAVVPLVSEDKSVTV----PEAENPRDSLVLPPTQSS----SDSS 738
++++ Q P + + + SE+++ T+ P + + L P + S + +
Sbjct: 855 ATAAQAQTGPEEDSGSSEEESDSEEEAETLAQVKPSGKTHQIRAALAPAKESPRKGAAPT 914
Query: 739 PPEVSGPSSSQMSMKTRRLSSA----STGKPPLSV 769
PP +GPS++Q + SS+ S G+ P +V
Sbjct: 915 PPGKTGPSAAQAGKQDDSGSSSEESDSDGEAPAAV 949
Score = 32.0 bits (71), Expect = 2.4
Identities = 76/405 (18%), Positives = 147/405 (36%), Gaps = 50/405 (12%)
Query: 150 PTHPPVVINAADDDEDDDDQFSEEGDETKTPTLQPTPEVHNGLRVTSVRKPAVNIKQGEC 209
P P + ++D + + S + + + PT P L KP + +G
Sbjct: 531 PATPSAQVGKWEEDSESSSEESSDSSDGEVPTAV-APAQEKSLGNILQAKPTSSPAKGPP 589
Query: 210 LNFGIKTLEEIKSKKMKEKSKKQGEGSSGVSSLLLHPEPVPGPEKENVRTVVRTVTLSTK 269
G ++ +K++K + S+ E S S E P T
Sbjct: 590 QKAGPVAVQ-VKAEKPMDNSESSEESSDSADS-----EEAPAA--------------MTA 629
Query: 270 QGEEPLVRLSLTERLGKRKFSAGGDSDPPLKRSLAQRLGKKVEAPETNIDKTPKKAQVSK 329
+P +++ T+ K+ + P++ + + +K + +P A ++
Sbjct: 630 AQAKPALKIPQTKACPKKTNTTASAKVAPVR--VGTQAPRKAGTATSPAGSSPAVAGGTQ 687
Query: 330 SLKERLGMSADPDNEDA-TDKVNKVGEIHVKTLEEILLERASQK--RGELQTKLKTEGPS 386
E S + D+E+ T VG+ K++ + L +A+ +G L P
Sbjct: 688 RPAEDSSSSEESDSEEEKTGLAVTVGQ--AKSVGKGLQVKAASVPVKGSLGQGTAPVLPG 745
Query: 387 KTDDSTSGARSSSTIRIKTFSEVLAEKKHRQQEAERQKSKKDTTCIKLKIDSEIKKTVVL 446
KT T ++V AEK+ + +E + ++ ++ + +KKT
Sbjct: 746 KTGP--------------TVTQVKAEKQEDSESSEEESDSEEAAASPAQVKTSVKKTQAK 791
Query: 447 PPIVASRGQSEE----PAGKTKSMQEVHIKTLEEIKLEKALRVQQSSESSTSSPSQHEAT 502
A+R S + GK + K K++ +R Q+S P+ +
Sbjct: 792 ANPAAARAPSAKGTISAPGKVVT-AAAQAKQRSPSKVKPPVRNPQNSTVLARGPASVPSV 850
Query: 503 PGARRLLRITKRTGMKEEKNLQEGNEVDSQSSIRTEAK-EASGET 546
G +TG +E+ E E DS+ T A+ + SG+T
Sbjct: 851 -GKAVATAAQAQTGPEEDSGSSE-EESDSEEEAETLAQVKPSGKT 893
>gi|207113160 Treacher Collins-Franceschetti syndrome 1 isoform d
[Homo sapiens]
Length = 1488
Score = 46.6 bits (109), Expect = 9e-05
Identities = 132/626 (21%), Positives = 212/626 (33%), Gaps = 100/626 (15%)
Query: 163 DEDDDDQFSEEGDETKTPTLQPTPEVHNGLRVTSVRKPAVNIKQGECLNFGIKTLEEIKS 222
D + SEE +E + T + TP + + N + + S
Sbjct: 80 DPISTSESSEEEEEAEAETAKATPRLAS-------------------TNSSVLGADLPSS 120
Query: 223 KKMKEKSKKQGEGSSGVSSLLLHPEPVPGPEKENVRTVVRTVTLSTKQGEEPLVRLSL-T 281
K K K++ + G +G S P P G N+ + S ++ EP +L +
Sbjct: 121 MKEKAKAETEKAGKTGNSM----PHPATGKTVANLLS-----GKSPRKSAEPSANTTLVS 171
Query: 282 ERLGKRKFSAGGDSDPPLKRSLAQRLGKKVE----APETNIDKTP--KKAQV---SKSLK 332
E + A G + P S Q + + ET+++ P K AQV S S K
Sbjct: 172 ETEEEGSVPAFGAAAKPGMVSAGQADSSSEDTSSSSDETDVEGKPSVKPAQVKASSVSTK 231
Query: 333 ERLGMSADPDNEDATDKVNKVGEIHVKTLEEILLERASQKRGELQTKLKTEGPSKTDDST 392
E A P KVG++ + L K+ E +++ EG +++
Sbjct: 232 ESPARKAAP-------APGKVGDVTPQVKGGALPPAKRAKKPEEESESSEEGSESEEEAP 284
Query: 393 SGARSSSTIRIKTFSEVLAEKKHRQQEAERQKSKKDTTCIKLKIDSEIKKTVVLPPIVAS 452
+G RS +V A +K Q A +K + K PP A
Sbjct: 285 AGTRS----------QVKASEKILQVRAASAPAK----------GTPGKGATPAPPGKAG 324
Query: 453 RGQSEEPAGKTKSMQEVHIKTLEEIKLEKALRVQQSSESSTSSPSQHEATPGARRLLRIT 512
S+ AGK + + S SS S E TP A+ LL+
Sbjct: 325 AVASQTKAGKPE---------------------EDSESSSEESSDSEEETPAAKALLQ-A 362
Query: 513 KRTGMKEEKNLQEGN-EVDSQSSIRTEAKEASGETTGVDITKIQV-KRCETMREKHMQKQ 570
K +G K Q G ++ S R A A TG + K Q KR E + +
Sbjct: 363 KASG----KTSQVGAASAPAKESPRKGAAPAPPGKTGPAVAKAQAGKREEDSQSSSEESD 418
Query: 571 QEREKSVLTPLRG---DVASCNTQVAEKPVLTAVPGITRHLTKRLPTKSSQKVEVETSGI 627
E E G V + + E P A P R K P + +V +
Sbjct: 419 SEEEAPAQAKPSGKAPQVRAASAPAKESPRKGAAPAPPR---KTGPAAAQVQVGKQEEDS 475
Query: 628 GDSLLNVKCAAQTLEKRGKAKPKVNVKPSVVKVVSSPKLAPKRK-AVEMHAAVIAAVKPL 686
S + L A+ K K VK S+ + P K A + + P
Sbjct: 476 RSSSEESDSDREALAAMNAAQVKPLGKSPQVKPASTMGMGPLGKGAGPVPPGKVGPATPS 535
Query: 687 SSSSVLQEPPAKKAAVAVVPLVSEDKSVTVPEAENPRDSLVLPPTQSSSDSSPPEVSGPS 746
+ +E + + E + P E +++ SS PP+ +GP
Sbjct: 536 AQVGKWEEDSESSSEESSDSSDGEVPTAVAPAQEKSLGNILQAKPTSSPAKGPPQKAGPV 595
Query: 747 SSQMSMKTRRLSSASTGKPPLSVEDD 772
+ Q+ + +S S+ + S + +
Sbjct: 596 AVQVKAEKPMDNSESSEESSDSADSE 621
Score = 37.0 bits (84), Expect = 0.073
Identities = 80/407 (19%), Positives = 149/407 (36%), Gaps = 32/407 (7%)
Query: 101 VLPTVPESPEEEVKASQLSVQQNKLSVQSNPSPQLRSVMKVESSENVPSPTHPPVVINAA 160
V T P S + + + SVQ+ + +LR E + +P ++
Sbjct: 1091 VARTQPSSGVDSAVGTLPATSPQSTSVQAKGTNKLRKPKLPEVQQATKAP-------ESS 1143
Query: 161 DDDEDDDDQFSEEGDETKTP-------TLQPTPEVHNGLRVTSVRKPAVN--IKQGECLN 211
DD ED D S ++ + P TL PTP L + + + + + + L
Sbjct: 1144 DDSEDSSDSSSGSEEDGEGPQGAKSAHTLGPTPSRTETLVEETAAESSEDDVVAPSQSLL 1203
Query: 212 FGIKTLEEIKSKKMKEKSKKQGEGSSGVSSLLLHPEPVPGPEKENVRTVVRTVTLSTKQG 271
G T + K+ + + S VSS L + G K+ + LS K G
Sbjct: 1204 SGYMTPGLTPANSQASKATPKLDSSPSVSSTLAAKDDPDG--KQEAKPQQAAGMLSPKTG 1261
Query: 272 EEPLVRLSLTERLGKRKFSAGGDSDPPLKRSLAQRLGKKVEAPETNIDKTPKKAQVSKSL 331
+ + ++ K K AG L +L + + + +++ +A V K L
Sbjct: 1262 GKEAASGTTPQKSRKPKKGAGNPQASTL--ALQSNITQCLLGQPWPLNEAQVQASVVKVL 1319
Query: 332 KERLGMSADPDNEDATDKVNKVGEIHVKTLEEILLERASQKRGELQTKLKTEGPSKTDDS 391
E L + + K E + L ++ + + + K K + S
Sbjct: 1320 TELLEQERKKVVDTTKESSRKGWESRKRKLSG---DQPAARTPRSKKKKKLGAGEGGEAS 1376
Query: 392 TSGARSSSTIRIKTFSEVLAEKKHRQQEAERQKSKKDTTCIKLKIDSEIKKTVVLPPIVA 451
S ++S+T + + +K + ++ K + K + + E++K + V
Sbjct: 1377 VSPEKTSTTSK----GKAKRDKASGDVKEKKGKGSLGSQGAKDEPEEELQKGM---GTVE 1429
Query: 452 SRGQSEEPAGKTKSMQEVHIKTLEEIKLEKALRVQQSSESSTSSPSQ 498
QS + K K + K E K EK + +++S + SPSQ
Sbjct: 1430 GGDQSNPKSKKEKKKSDKRKKDKE--KKEKKKKAKKASTKDSESPSQ 1474
Score = 34.7 bits (78), Expect = 0.36
Identities = 74/395 (18%), Positives = 143/395 (36%), Gaps = 55/395 (13%)
Query: 410 LAEKKHRQQEAERQKSKKDTTCIKLKIDSEIKKTVVLPPIVASRGQSEEPAGKTKSMQEV 469
+ + K A+ K +++K + + + S E PA T + +
Sbjct: 575 ILQAKPTSSPAKGPPQKAGPVAVQVKAEKPMDNSESSEESSDSADSEEAPAAMTAAQAKP 634
Query: 470 HIKTLEEIKLEKALRVQQSSESSTSSPSQHEATPGARRLLRITKRTGMKEEKNLQEGNEV 529
+K I KA + ++ +S T R+ T G + G +
Sbjct: 635 ALK----IPQTKACPKKTNTTASAKVAPVRVGTQAPRKAGTATSPAGSSPA--VAGGTQR 688
Query: 530 DSQSSIRTEAKEASGETTGVDITKIQVKRCETMREKHMQKQQEREKSVLTPLRGDVASCN 589
++ S +E ++ E TG+ +T Q K K +Q K+ P++G +
Sbjct: 689 PAEDSSSSEESDSEEEKTGLAVTVGQAKSVG----KGLQV-----KAASVPVKGSLGQ-- 737
Query: 590 TQVAEKPVLTAVPGITRHLTKRLPTKSSQKVEVETSGIGDSLLNVKCAAQTLEKRGKAKP 649
PVL G T K + S+ E E+ + + + + KA P
Sbjct: 738 ---GTAPVLPGKTGPTVTQVKAEKQEDSESSEEESDSEEAAASPAQVKTSVKKTQAKANP 794
Query: 650 KVNVKPSVVKVVSSP----------------KLAPKRKAVEMH-------AAVIAAVKPL 686
PS +S+P K+ P + + A+V + K +
Sbjct: 795 AAARAPSAKGTISAPGKVVTAAAQAKQRSPSKVKPPVRNPQNSTVLARGPASVPSVGKAV 854
Query: 687 SSSSVLQEPPAKKAAVAVVPLVSEDKSVTV----PEAENPRDSLVLPPTQSS----SDSS 738
++++ Q P + + + SE+++ T+ P + + L P + S + +
Sbjct: 855 ATAAQAQTGPEEDSGSSEEESDSEEEAETLAQVKPSGKTHQIRAALAPAKESPRKGAAPT 914
Query: 739 PPEVSGPSSSQMSMKTRRLSSA----STGKPPLSV 769
PP +GPS++Q + SS+ S G+ P +V
Sbjct: 915 PPGKTGPSAAQAGKQDDSGSSSEESDSDGEAPAAV 949
Score = 32.0 bits (71), Expect = 2.4
Identities = 76/405 (18%), Positives = 147/405 (36%), Gaps = 50/405 (12%)
Query: 150 PTHPPVVINAADDDEDDDDQFSEEGDETKTPTLQPTPEVHNGLRVTSVRKPAVNIKQGEC 209
P P + ++D + + S + + + PT P L KP + +G
Sbjct: 531 PATPSAQVGKWEEDSESSSEESSDSSDGEVPTAV-APAQEKSLGNILQAKPTSSPAKGPP 589
Query: 210 LNFGIKTLEEIKSKKMKEKSKKQGEGSSGVSSLLLHPEPVPGPEKENVRTVVRTVTLSTK 269
G ++ +K++K + S+ E S S E P T
Sbjct: 590 QKAGPVAVQ-VKAEKPMDNSESSEESSDSADS-----EEAPAA--------------MTA 629
Query: 270 QGEEPLVRLSLTERLGKRKFSAGGDSDPPLKRSLAQRLGKKVEAPETNIDKTPKKAQVSK 329
+P +++ T+ K+ + P++ + + +K + +P A ++
Sbjct: 630 AQAKPALKIPQTKACPKKTNTTASAKVAPVR--VGTQAPRKAGTATSPAGSSPAVAGGTQ 687
Query: 330 SLKERLGMSADPDNEDA-TDKVNKVGEIHVKTLEEILLERASQK--RGELQTKLKTEGPS 386
E S + D+E+ T VG+ K++ + L +A+ +G L P
Sbjct: 688 RPAEDSSSSEESDSEEEKTGLAVTVGQ--AKSVGKGLQVKAASVPVKGSLGQGTAPVLPG 745
Query: 387 KTDDSTSGARSSSTIRIKTFSEVLAEKKHRQQEAERQKSKKDTTCIKLKIDSEIKKTVVL 446
KT T ++V AEK+ + +E + ++ ++ + +KKT
Sbjct: 746 KTGP--------------TVTQVKAEKQEDSESSEEESDSEEAAASPAQVKTSVKKTQAK 791
Query: 447 PPIVASRGQSEE----PAGKTKSMQEVHIKTLEEIKLEKALRVQQSSESSTSSPSQHEAT 502
A+R S + GK + K K++ +R Q+S P+ +
Sbjct: 792 ANPAAARAPSAKGTISAPGKVVT-AAAQAKQRSPSKVKPPVRNPQNSTVLARGPASVPSV 850
Query: 503 PGARRLLRITKRTGMKEEKNLQEGNEVDSQSSIRTEAK-EASGET 546
G +TG +E+ E E DS+ T A+ + SG+T
Sbjct: 851 -GKAVATAAQAQTGPEEDSGSSE-EESDSEEEAETLAQVKPSGKT 893
>gi|57164977 Treacher Collins-Franceschetti syndrome 1 isoform a
[Homo sapiens]
Length = 1450
Score = 46.6 bits (109), Expect = 9e-05
Identities = 132/626 (21%), Positives = 212/626 (33%), Gaps = 100/626 (15%)
Query: 163 DEDDDDQFSEEGDETKTPTLQPTPEVHNGLRVTSVRKPAVNIKQGECLNFGIKTLEEIKS 222
D + SEE +E + T + TP + + N + + S
Sbjct: 80 DPISTSESSEEEEEAEAETAKATPRLAS-------------------TNSSVLGADLPSS 120
Query: 223 KKMKEKSKKQGEGSSGVSSLLLHPEPVPGPEKENVRTVVRTVTLSTKQGEEPLVRLSL-T 281
K K K++ + G +G S P P G N+ + S ++ EP +L +
Sbjct: 121 MKEKAKAETEKAGKTGNSM----PHPATGKTVANLLS-----GKSPRKSAEPSANTTLVS 171
Query: 282 ERLGKRKFSAGGDSDPPLKRSLAQRLGKKVE----APETNIDKTP--KKAQV---SKSLK 332
E + A G + P S Q + + ET+++ P K AQV S S K
Sbjct: 172 ETEEEGSVPAFGAAAKPGMVSAGQADSSSEDTSSSSDETDVEGKPSVKPAQVKASSVSTK 231
Query: 333 ERLGMSADPDNEDATDKVNKVGEIHVKTLEEILLERASQKRGELQTKLKTEGPSKTDDST 392
E A P KVG++ + L K+ E +++ EG +++
Sbjct: 232 ESPARKAAP-------APGKVGDVTPQVKGGALPPAKRAKKPEEESESSEEGSESEEEAP 284
Query: 393 SGARSSSTIRIKTFSEVLAEKKHRQQEAERQKSKKDTTCIKLKIDSEIKKTVVLPPIVAS 452
+G RS +V A +K Q A +K + K PP A
Sbjct: 285 AGTRS----------QVKASEKILQVRAASAPAK----------GTPGKGATPAPPGKAG 324
Query: 453 RGQSEEPAGKTKSMQEVHIKTLEEIKLEKALRVQQSSESSTSSPSQHEATPGARRLLRIT 512
S+ AGK + + S SS S E TP A+ LL+
Sbjct: 325 AVASQTKAGKPE---------------------EDSESSSEESSDSEEETPAAKALLQ-A 362
Query: 513 KRTGMKEEKNLQEGN-EVDSQSSIRTEAKEASGETTGVDITKIQV-KRCETMREKHMQKQ 570
K +G K Q G ++ S R A A TG + K Q KR E + +
Sbjct: 363 KASG----KTSQVGAASAPAKESPRKGAAPAPPGKTGPAVAKAQAGKREEDSQSSSEESD 418
Query: 571 QEREKSVLTPLRG---DVASCNTQVAEKPVLTAVPGITRHLTKRLPTKSSQKVEVETSGI 627
E E G V + + E P A P R K P + +V +
Sbjct: 419 SEEEAPAQAKPSGKAPQVRAASAPAKESPRKGAAPAPPR---KTGPAAAQVQVGKQEEDS 475
Query: 628 GDSLLNVKCAAQTLEKRGKAKPKVNVKPSVVKVVSSPKLAPKRK-AVEMHAAVIAAVKPL 686
S + L A+ K K VK S+ + P K A + + P
Sbjct: 476 RSSSEESDSDREALAAMNAAQVKPLGKSPQVKPASTMGMGPLGKGAGPVPPGKVGPATPS 535
Query: 687 SSSSVLQEPPAKKAAVAVVPLVSEDKSVTVPEAENPRDSLVLPPTQSSSDSSPPEVSGPS 746
+ +E + + E + P E +++ SS PP+ +GP
Sbjct: 536 AQVGKWEEDSESSSEESSDSSDGEVPTAVAPAQEKSLGNILQAKPTSSPAKGPPQKAGPV 595
Query: 747 SSQMSMKTRRLSSASTGKPPLSVEDD 772
+ Q+ + +S S+ + S + +
Sbjct: 596 AVQVKAEKPMDNSESSEESSDSADSE 621
Score = 34.7 bits (78), Expect = 0.36
Identities = 74/395 (18%), Positives = 143/395 (36%), Gaps = 55/395 (13%)
Query: 410 LAEKKHRQQEAERQKSKKDTTCIKLKIDSEIKKTVVLPPIVASRGQSEEPAGKTKSMQEV 469
+ + K A+ K +++K + + + S E PA T + +
Sbjct: 575 ILQAKPTSSPAKGPPQKAGPVAVQVKAEKPMDNSESSEESSDSADSEEAPAAMTAAQAKP 634
Query: 470 HIKTLEEIKLEKALRVQQSSESSTSSPSQHEATPGARRLLRITKRTGMKEEKNLQEGNEV 529
+K I KA + ++ +S T R+ T G + G +
Sbjct: 635 ALK----IPQTKACPKKTNTTASAKVAPVRVGTQAPRKAGTATSPAGSSPA--VAGGTQR 688
Query: 530 DSQSSIRTEAKEASGETTGVDITKIQVKRCETMREKHMQKQQEREKSVLTPLRGDVASCN 589
++ S +E ++ E TG+ +T Q K K +Q K+ P++G +
Sbjct: 689 PAEDSSSSEESDSEEEKTGLAVTVGQAKSVG----KGLQV-----KAASVPVKGSLGQ-- 737
Query: 590 TQVAEKPVLTAVPGITRHLTKRLPTKSSQKVEVETSGIGDSLLNVKCAAQTLEKRGKAKP 649
PVL G T K + S+ E E+ + + + + KA P
Sbjct: 738 ---GTAPVLPGKTGPTVTQVKAEKQEDSESSEEESDSEEAAASPAQVKTSVKKTQAKANP 794
Query: 650 KVNVKPSVVKVVSSP----------------KLAPKRKAVEMH-------AAVIAAVKPL 686
PS +S+P K+ P + + A+V + K +
Sbjct: 795 AAARAPSAKGTISAPGKVVTAAAQAKQRSPSKVKPPVRNPQNSTVLARGPASVPSVGKAV 854
Query: 687 SSSSVLQEPPAKKAAVAVVPLVSEDKSVTV----PEAENPRDSLVLPPTQSS----SDSS 738
++++ Q P + + + SE+++ T+ P + + L P + S + +
Sbjct: 855 ATAAQAQTGPEEDSGSSEEESDSEEEAETLAQVKPSGKTHQIRAALAPAKESPRKGAAPT 914
Query: 739 PPEVSGPSSSQMSMKTRRLSSA----STGKPPLSV 769
PP +GPS++Q + SS+ S G+ P +V
Sbjct: 915 PPGKTGPSAAQAGKQDDSGSSSEESDSDGEAPAAV 949
Score = 32.0 bits (71), Expect = 2.4
Identities = 76/405 (18%), Positives = 147/405 (36%), Gaps = 50/405 (12%)
Query: 150 PTHPPVVINAADDDEDDDDQFSEEGDETKTPTLQPTPEVHNGLRVTSVRKPAVNIKQGEC 209
P P + ++D + + S + + + PT P L KP + +G
Sbjct: 531 PATPSAQVGKWEEDSESSSEESSDSSDGEVPTAV-APAQEKSLGNILQAKPTSSPAKGPP 589
Query: 210 LNFGIKTLEEIKSKKMKEKSKKQGEGSSGVSSLLLHPEPVPGPEKENVRTVVRTVTLSTK 269
G ++ +K++K + S+ E S S E P T
Sbjct: 590 QKAGPVAVQ-VKAEKPMDNSESSEESSDSADS-----EEAPAA--------------MTA 629
Query: 270 QGEEPLVRLSLTERLGKRKFSAGGDSDPPLKRSLAQRLGKKVEAPETNIDKTPKKAQVSK 329
+P +++ T+ K+ + P++ + + +K + +P A ++
Sbjct: 630 AQAKPALKIPQTKACPKKTNTTASAKVAPVR--VGTQAPRKAGTATSPAGSSPAVAGGTQ 687
Query: 330 SLKERLGMSADPDNEDA-TDKVNKVGEIHVKTLEEILLERASQK--RGELQTKLKTEGPS 386
E S + D+E+ T VG+ K++ + L +A+ +G L P
Sbjct: 688 RPAEDSSSSEESDSEEEKTGLAVTVGQ--AKSVGKGLQVKAASVPVKGSLGQGTAPVLPG 745
Query: 387 KTDDSTSGARSSSTIRIKTFSEVLAEKKHRQQEAERQKSKKDTTCIKLKIDSEIKKTVVL 446
KT T ++V AEK+ + +E + ++ ++ + +KKT
Sbjct: 746 KTGP--------------TVTQVKAEKQEDSESSEEESDSEEAAASPAQVKTSVKKTQAK 791
Query: 447 PPIVASRGQSEE----PAGKTKSMQEVHIKTLEEIKLEKALRVQQSSESSTSSPSQHEAT 502
A+R S + GK + K K++ +R Q+S P+ +
Sbjct: 792 ANPAAARAPSAKGTISAPGKVVT-AAAQAKQRSPSKVKPPVRNPQNSTVLARGPASVPSV 850
Query: 503 PGARRLLRITKRTGMKEEKNLQEGNEVDSQSSIRTEAK-EASGET 546
G +TG +E+ E E DS+ T A+ + SG+T
Sbjct: 851 -GKAVATAAQAQTGPEEDSGSSE-EESDSEEEAETLAQVKPSGKT 893
>gi|57164979 Treacher Collins-Franceschetti syndrome 1 isoform c
[Homo sapiens]
Length = 958
Score = 46.6 bits (109), Expect = 9e-05
Identities = 132/626 (21%), Positives = 212/626 (33%), Gaps = 100/626 (15%)
Query: 163 DEDDDDQFSEEGDETKTPTLQPTPEVHNGLRVTSVRKPAVNIKQGECLNFGIKTLEEIKS 222
D + SEE +E + T + TP + + N + + S
Sbjct: 80 DPISTSESSEEEEEAEAETAKATPRLAS-------------------TNSSVLGADLPSS 120
Query: 223 KKMKEKSKKQGEGSSGVSSLLLHPEPVPGPEKENVRTVVRTVTLSTKQGEEPLVRLSL-T 281
K K K++ + G +G S P P G N+ + S ++ EP +L +
Sbjct: 121 MKEKAKAETEKAGKTGNSM----PHPATGKTVANLLS-----GKSPRKSAEPSANTTLVS 171
Query: 282 ERLGKRKFSAGGDSDPPLKRSLAQRLGKKVE----APETNIDKTP--KKAQV---SKSLK 332
E + A G + P S Q + + ET+++ P K AQV S S K
Sbjct: 172 ETEEEGSVPAFGAAAKPGMVSAGQADSSSEDTSSSSDETDVEGKPSVKPAQVKASSVSTK 231
Query: 333 ERLGMSADPDNEDATDKVNKVGEIHVKTLEEILLERASQKRGELQTKLKTEGPSKTDDST 392
E A P KVG++ + L K+ E +++ EG +++
Sbjct: 232 ESPARKAAP-------APGKVGDVTPQVKGGALPPAKRAKKPEEESESSEEGSESEEEAP 284
Query: 393 SGARSSSTIRIKTFSEVLAEKKHRQQEAERQKSKKDTTCIKLKIDSEIKKTVVLPPIVAS 452
+G RS +V A +K Q A +K + K PP A
Sbjct: 285 AGTRS----------QVKASEKILQVRAASAPAK----------GTPGKGATPAPPGKAG 324
Query: 453 RGQSEEPAGKTKSMQEVHIKTLEEIKLEKALRVQQSSESSTSSPSQHEATPGARRLLRIT 512
S+ AGK + + S SS S E TP A+ LL+
Sbjct: 325 AVASQTKAGKPE---------------------EDSESSSEESSDSEEETPAAKALLQ-A 362
Query: 513 KRTGMKEEKNLQEGN-EVDSQSSIRTEAKEASGETTGVDITKIQV-KRCETMREKHMQKQ 570
K +G K Q G ++ S R A A TG + K Q KR E + +
Sbjct: 363 KASG----KTSQVGAASAPAKESPRKGAAPAPPGKTGPAVAKAQAGKREEDSQSSSEESD 418
Query: 571 QEREKSVLTPLRG---DVASCNTQVAEKPVLTAVPGITRHLTKRLPTKSSQKVEVETSGI 627
E E G V + + E P A P R K P + +V +
Sbjct: 419 SEEEAPAQAKPSGKAPQVRAASAPAKESPRKGAAPAPPR---KTGPAAAQVQVGKQEEDS 475
Query: 628 GDSLLNVKCAAQTLEKRGKAKPKVNVKPSVVKVVSSPKLAPKRK-AVEMHAAVIAAVKPL 686
S + L A+ K K VK S+ + P K A + + P
Sbjct: 476 RSSSEESDSDREALAAMNAAQVKPLGKSPQVKPASTMGMGPLGKGAGPVPPGKVGPATPS 535
Query: 687 SSSSVLQEPPAKKAAVAVVPLVSEDKSVTVPEAENPRDSLVLPPTQSSSDSSPPEVSGPS 746
+ +E + + E + P E +++ SS PP+ +GP
Sbjct: 536 AQVGKWEEDSESSSEESSDSSDGEVPTAVAPAQEKSLGNILQAKPTSSPAKGPPQKAGPV 595
Query: 747 SSQMSMKTRRLSSASTGKPPLSVEDD 772
+ Q+ + +S S+ + S + +
Sbjct: 596 AVQVKAEKPMDNSESSEESSDSADSE 621
Score = 34.7 bits (78), Expect = 0.36
Identities = 74/395 (18%), Positives = 143/395 (36%), Gaps = 55/395 (13%)
Query: 410 LAEKKHRQQEAERQKSKKDTTCIKLKIDSEIKKTVVLPPIVASRGQSEEPAGKTKSMQEV 469
+ + K A+ K +++K + + + S E PA T + +
Sbjct: 575 ILQAKPTSSPAKGPPQKAGPVAVQVKAEKPMDNSESSEESSDSADSEEAPAAMTAAQAKP 634
Query: 470 HIKTLEEIKLEKALRVQQSSESSTSSPSQHEATPGARRLLRITKRTGMKEEKNLQEGNEV 529
+K I KA + ++ +S T R+ T G + G +
Sbjct: 635 ALK----IPQTKACPKKTNTTASAKVAPVRVGTQAPRKAGTATSPAGSSPA--VAGGTQR 688
Query: 530 DSQSSIRTEAKEASGETTGVDITKIQVKRCETMREKHMQKQQEREKSVLTPLRGDVASCN 589
++ S +E ++ E TG+ +T Q K K +Q K+ P++G +
Sbjct: 689 PAEDSSSSEESDSEEEKTGLAVTVGQAKSVG----KGLQV-----KAASVPVKGSLGQ-- 737
Query: 590 TQVAEKPVLTAVPGITRHLTKRLPTKSSQKVEVETSGIGDSLLNVKCAAQTLEKRGKAKP 649
PVL G T K + S+ E E+ + + + + KA P
Sbjct: 738 ---GTAPVLPGKTGPTVTQVKAEKQEDSESSEEESDSEEAAASPAQVKTSVKKTQAKANP 794
Query: 650 KVNVKPSVVKVVSSP----------------KLAPKRKAVEMH-------AAVIAAVKPL 686
PS +S+P K+ P + + A+V + K +
Sbjct: 795 AAARAPSAKGTISAPGKVVTAAAQAKQRSPSKVKPPVRNPQNSTVLARGPASVPSVGKAV 854
Query: 687 SSSSVLQEPPAKKAAVAVVPLVSEDKSVTV----PEAENPRDSLVLPPTQSS----SDSS 738
++++ Q P + + + SE+++ T+ P + + L P + S + +
Sbjct: 855 ATAAQAQTGPEEDSGSSEEESDSEEEAETLAQVKPSGKTHQIRAALAPAKESPRKGAAPT 914
Query: 739 PPEVSGPSSSQMSMKTRRLSSA----STGKPPLSV 769
PP +GPS++Q + SS+ S G+ P +V
Sbjct: 915 PPGKTGPSAAQAGKQDDSGSSSEESDSDGEAPAAV 949
Score = 32.0 bits (71), Expect = 2.4
Identities = 76/405 (18%), Positives = 147/405 (36%), Gaps = 50/405 (12%)
Query: 150 PTHPPVVINAADDDEDDDDQFSEEGDETKTPTLQPTPEVHNGLRVTSVRKPAVNIKQGEC 209
P P + ++D + + S + + + PT P L KP + +G
Sbjct: 531 PATPSAQVGKWEEDSESSSEESSDSSDGEVPTAV-APAQEKSLGNILQAKPTSSPAKGPP 589
Query: 210 LNFGIKTLEEIKSKKMKEKSKKQGEGSSGVSSLLLHPEPVPGPEKENVRTVVRTVTLSTK 269
G ++ +K++K + S+ E S S E P T
Sbjct: 590 QKAGPVAVQ-VKAEKPMDNSESSEESSDSADS-----EEAPAA--------------MTA 629
Query: 270 QGEEPLVRLSLTERLGKRKFSAGGDSDPPLKRSLAQRLGKKVEAPETNIDKTPKKAQVSK 329
+P +++ T+ K+ + P++ + + +K + +P A ++
Sbjct: 630 AQAKPALKIPQTKACPKKTNTTASAKVAPVR--VGTQAPRKAGTATSPAGSSPAVAGGTQ 687
Query: 330 SLKERLGMSADPDNEDA-TDKVNKVGEIHVKTLEEILLERASQK--RGELQTKLKTEGPS 386
E S + D+E+ T VG+ K++ + L +A+ +G L P
Sbjct: 688 RPAEDSSSSEESDSEEEKTGLAVTVGQ--AKSVGKGLQVKAASVPVKGSLGQGTAPVLPG 745
Query: 387 KTDDSTSGARSSSTIRIKTFSEVLAEKKHRQQEAERQKSKKDTTCIKLKIDSEIKKTVVL 446
KT T ++V AEK+ + +E + ++ ++ + +KKT
Sbjct: 746 KTGP--------------TVTQVKAEKQEDSESSEEESDSEEAAASPAQVKTSVKKTQAK 791
Query: 447 PPIVASRGQSEE----PAGKTKSMQEVHIKTLEEIKLEKALRVQQSSESSTSSPSQHEAT 502
A+R S + GK + K K++ +R Q+S P+ +
Sbjct: 792 ANPAAARAPSAKGTISAPGKVVT-AAAQAKQRSPSKVKPPVRNPQNSTVLARGPASVPSV 850
Query: 503 PGARRLLRITKRTGMKEEKNLQEGNEVDSQSSIRTEAK-EASGET 546
G +TG +E+ E E DS+ T A+ + SG+T
Sbjct: 851 -GKAVATAAQAQTGPEEDSGSSE-EESDSEEEAETLAQVKPSGKT 893
Database: hs.faa
Posted date: Aug 4, 2009 4:42 PM
Number of letters in database: 18,247,518
Number of sequences in database: 37,866
Lambda K H
0.308 0.125 0.345
Gapped
Lambda K H
0.267 0.0410 0.140
Matrix: BLOSUM62
Gap Penalties: Existence: 11, Extension: 1
Number of Hits to DB: 32,767,235
Number of Sequences: 37866
Number of extensions: 1591881
Number of successful extensions: 9603
Number of sequences better than 10.0: 30
Number of HSP's better than 10.0 without gapping: 57
Number of HSP's successfully gapped in prelim test: 568
Number of HSP's that attempted gapping in prelim test: 8228
Number of HSP's gapped (non-prelim): 1792
length of query: 810
length of database: 18,247,518
effective HSP length: 110
effective length of query: 700
effective length of database: 14,082,258
effective search space: 9857580600
effective search space used: 9857580600
T: 11
A: 40
X1: 16 ( 7.1 bits)
X2: 38 (14.6 bits)
X3: 64 (24.7 bits)
S1: 42 (21.6 bits)
S2: 66 (30.0 bits)
Search results were obtained with NCBI BLAST and RefSeq entries.
Home |
Table of Contents |
Search text |
Search genes |
Search sequences |
Purchase |
FAQ |
Blog |
Help
Guide to the Human Genome
Copyright © 2010 by Stewart Scherer. All rights reserved.