Guide to the Human Genome
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Search of human proteins with 219842233

BLASTP 2.2.11 [Jun-05-2005]


Reference: Altschul, Stephen F., Thomas L. Madden, Alejandro A. Schaffer, 
Jinghui Zhang, Zheng Zhang, Webb Miller, and David J. Lipman (1997), 
"Gapped BLAST and PSI-BLAST: a new generation of protein database search
programs",  Nucleic Acids Res. 25:3389-3402.

Query= gi|219842233 feline sarcoma oncogene isoform 3 [Homo sapiens]
         (752 letters)

Database: hs.faa 
           37,866 sequences; 18,247,518 total letters

Searching..................................................done

                                                                 Score    E
Sequences producing significant alignments:                      (bits) Value

gi|219842233 feline sarcoma oncogene isoform 3 [Homo sapiens]        1498   0.0  
gi|4503687 feline sarcoma oncogene isoform 1 [Homo sapiens]          1349   0.0  
gi|219842236 feline sarcoma oncogene isoform 4 [Homo sapiens]        1246   0.0  
gi|219842230 feline sarcoma oncogene isoform 2 [Homo sapiens]        1097   0.0  
gi|119964721 fer (fps/fes related) tyrosine kinase [Homo sapiens]     580   e-165
gi|62362414 c-abl oncogene 1, receptor tyrosine kinase isoform a...   238   2e-62
gi|62362412 c-abl oncogene 1, receptor tyrosine kinase isoform b...   238   2e-62
gi|153266778 arg tyrosine kinase isoform c [Homo sapiens]             232   1e-60
gi|6382062 arg tyrosine kinase isoform b [Homo sapiens]               232   1e-60
gi|209862778 arg tyrosine kinase isoform e [Homo sapiens]             232   1e-60
gi|209862772 arg tyrosine kinase isoform d [Homo sapiens]             232   1e-60
gi|153266757 arg tyrosine kinase isoform a [Homo sapiens]             232   1e-60
gi|21450844 megakaryocyte-associated tyrosine kinase isoform c [...   226   5e-59
gi|21450842 megakaryocyte-associated tyrosine kinase isoform b [...   226   5e-59
gi|21450846 megakaryocyte-associated tyrosine kinase isoform a [...   226   5e-59
gi|130977759 tec protein tyrosine kinase [Homo sapiens]               226   8e-59
gi|15718680 IL2-inducible T-cell kinase [Homo sapiens]                225   1e-58
gi|4502435 BMX non-receptor tyrosine kinase [Homo sapiens]            223   4e-58
gi|42544182 BMX non-receptor tyrosine kinase [Homo sapiens]           223   4e-58
gi|29029632 anaplastic lymphoma kinase [Homo sapiens]                 220   3e-57
gi|148596974 TXK tyrosine kinase [Homo sapiens]                       220   3e-57
gi|19924165 proto-oncogene c-ros-1 protein precursor [Homo sapiens]   220   4e-57
gi|4557665 insulin-like growth factor 1 receptor precursor [Homo...   218   1e-56
gi|18250298 src-related kinase lacking C-terminal regulatory tyr...   217   3e-56
gi|221316650 ephrin receptor EphA1 [Homo sapiens]                     215   1e-55
gi|4557377 Bruton agammaglobulinemia tyrosine kinase [Homo sapiens]   214   2e-55
gi|4503823 protein-tyrosine kinase fyn isoform a [Homo sapiens]       213   4e-55
gi|38202217 proto-oncogene tyrosine-protein kinase SRC [Homo sap...   211   3e-54
gi|4885609 proto-oncogene tyrosine-protein kinase SRC [Homo sapi...   211   3e-54
gi|42544153 leukocyte receptor tyrosine kinase isoform 1 precurs...   211   3e-54

>gi|219842233 feline sarcoma oncogene isoform 3 [Homo sapiens]
          Length = 752

 Score = 1498 bits (3879), Expect = 0.0
 Identities = 752/752 (100%), Positives = 752/752 (100%)

Query: 1   MGFSSELCSPQGHGVLQQMQEAELRLLEGMRKWMAQRVKSDREYAGLLHHMSLQDSGGQS 60
           MGFSSELCSPQGHGVLQQMQEAELRLLEGMRKWMAQRVKSDREYAGLLHHMSLQDSGGQS
Sbjct: 1   MGFSSELCSPQGHGVLQQMQEAELRLLEGMRKWMAQRVKSDREYAGLLHHMSLQDSGGQS 60

Query: 61  RAISPDSPISQSWAEITSQTEGLSRLLRQHAEDLNSGPLSKLSLLIRERQQLRKTYSEQW 120
           RAISPDSPISQSWAEITSQTEGLSRLLRQHAEDLNSGPLSKLSLLIRERQQLRKTYSEQW
Sbjct: 61  RAISPDSPISQSWAEITSQTEGLSRLLRQHAEDLNSGPLSKLSLLIRERQQLRKTYSEQW 120

Query: 121 QQLQQELTKTHSQDIEKLKSQYRALARDSAQAKRKYQEASKDKDRDKAKDKYVRSLWKLF 180
           QQLQQELTKTHSQDIEKLKSQYRALARDSAQAKRKYQEASKDKDRDKAKDKYVRSLWKLF
Sbjct: 121 QQLQQELTKTHSQDIEKLKSQYRALARDSAQAKRKYQEASKDKDRDKAKDKYVRSLWKLF 180

Query: 181 AHHNRYVLGVRAAQLHHQHHHQLLLPGLLRSLQDLHEEMACILKEILQEYLEISSLVQDE 240
           AHHNRYVLGVRAAQLHHQHHHQLLLPGLLRSLQDLHEEMACILKEILQEYLEISSLVQDE
Sbjct: 181 AHHNRYVLGVRAAQLHHQHHHQLLLPGLLRSLQDLHEEMACILKEILQEYLEISSLVQDE 240

Query: 241 VVAIHREMAAAAARIQPEAEYQGFLRQYGSAPDVPPCVTFDESLLEEGEPLEPGELQLNE 300
           VVAIHREMAAAAARIQPEAEYQGFLRQYGSAPDVPPCVTFDESLLEEGEPLEPGELQLNE
Sbjct: 241 VVAIHREMAAAAARIQPEAEYQGFLRQYGSAPDVPPCVTFDESLLEEGEPLEPGELQLNE 300

Query: 301 LTVESVQHTLTSVTDELAVATEMVFRRQEMVTQLQQELRNEEENTHPRERVQLLGKRQVL 360
           LTVESVQHTLTSVTDELAVATEMVFRRQEMVTQLQQELRNEEENTHPRERVQLLGKRQVL
Sbjct: 301 LTVESVQHTLTSVTDELAVATEMVFRRQEMVTQLQQELRNEEENTHPRERVQLLGKRQVL 360

Query: 361 QEALQGLQVALCSQAKLQAQQELLQTKLEHLGPGEPPPVLLLQDDRHSTSSSEQEREGGR 420
           QEALQGLQVALCSQAKLQAQQELLQTKLEHLGPGEPPPVLLLQDDRHSTSSSEQEREGGR
Sbjct: 361 QEALQGLQVALCSQAKLQAQQELLQTKLEHLGPGEPPPVLLLQDDRHSTSSSEQEREGGR 420

Query: 421 TPTLEILKSHISGIFRPKFSNLYRLEGEGFPSIPLLIDHLLSTQQPLTKKSGVVLHRAVP 480
           TPTLEILKSHISGIFRPKFSNLYRLEGEGFPSIPLLIDHLLSTQQPLTKKSGVVLHRAVP
Sbjct: 421 TPTLEILKSHISGIFRPKFSNLYRLEGEGFPSIPLLIDHLLSTQQPLTKKSGVVLHRAVP 480

Query: 481 KDKWVLNHEDLVLGEQIGRGNFGEVFSGRLRADNTLVAVKSCRETLPPDLKAKFLQEARI 540
           KDKWVLNHEDLVLGEQIGRGNFGEVFSGRLRADNTLVAVKSCRETLPPDLKAKFLQEARI
Sbjct: 481 KDKWVLNHEDLVLGEQIGRGNFGEVFSGRLRADNTLVAVKSCRETLPPDLKAKFLQEARI 540

Query: 541 LKQYSHPNIVRLIGVCTQKQPIYIVMELVQGGDFLTFLRTEGARLRVKTLLQMVGDAAAG 600
           LKQYSHPNIVRLIGVCTQKQPIYIVMELVQGGDFLTFLRTEGARLRVKTLLQMVGDAAAG
Sbjct: 541 LKQYSHPNIVRLIGVCTQKQPIYIVMELVQGGDFLTFLRTEGARLRVKTLLQMVGDAAAG 600

Query: 601 MEYLESKCCIHRDLAARNCLVTEKNVLKISDFGMSREEADGVYAASGGLRQVPVKWTAPE 660
           MEYLESKCCIHRDLAARNCLVTEKNVLKISDFGMSREEADGVYAASGGLRQVPVKWTAPE
Sbjct: 601 MEYLESKCCIHRDLAARNCLVTEKNVLKISDFGMSREEADGVYAASGGLRQVPVKWTAPE 660

Query: 661 ALNYGRYSSESDVWSFGILLWETFSLGASPYPNLSNQQTREFVEKGGRLPCPELCPDAVF 720
           ALNYGRYSSESDVWSFGILLWETFSLGASPYPNLSNQQTREFVEKGGRLPCPELCPDAVF
Sbjct: 661 ALNYGRYSSESDVWSFGILLWETFSLGASPYPNLSNQQTREFVEKGGRLPCPELCPDAVF 720

Query: 721 RLMEQCWAYEPGQRPSFSTIYQELQSIRKRHR 752
           RLMEQCWAYEPGQRPSFSTIYQELQSIRKRHR
Sbjct: 721 RLMEQCWAYEPGQRPSFSTIYQELQSIRKRHR 752


>gi|4503687 feline sarcoma oncogene isoform 1 [Homo sapiens]
          Length = 822

 Score = 1349 bits (3491), Expect = 0.0
 Identities = 706/822 (85%), Positives = 716/822 (87%), Gaps = 70/822 (8%)

Query: 1   MGFSSELCSPQGHGVLQQMQEAELRLLEGMRKWMAQRVKSDREYAGLLHHMSLQDSGGQS 60
           MGFSSELCSPQGHGVLQQMQEAELRLLEGMRKWMAQRVKSDREYAGLLHHMSLQDSGGQS
Sbjct: 1   MGFSSELCSPQGHGVLQQMQEAELRLLEGMRKWMAQRVKSDREYAGLLHHMSLQDSGGQS 60

Query: 61  RAISPDSPISQSWAEITSQTEGLSRLLRQHAEDLNSGPLSKLSLLIRERQQLRKTYSEQW 120
           RAISPDSPISQSWAEITSQTEGLSRLLRQHAEDLNSGPLSKLSLLIRERQQLRKTYSEQW
Sbjct: 61  RAISPDSPISQSWAEITSQTEGLSRLLRQHAEDLNSGPLSKLSLLIRERQQLRKTYSEQW 120

Query: 121 QQLQQELTKTHSQDIEKLKSQYRALARDSAQAKRKYQEASKDKDRDKAKDKYVRSLWKLF 180
           QQLQQELTKTHSQDIEKLKSQYRALARDSAQAKRKYQEASKDKDRDKAKDKYVRSLWKLF
Sbjct: 121 QQLQQELTKTHSQDIEKLKSQYRALARDSAQAKRKYQEASKDKDRDKAKDKYVRSLWKLF 180

Query: 181 AHHNRYVLGVRAAQLHHQHHHQLLLPGLLRSLQDLHEEMACILKEILQEYLEISSLVQDE 240
           AHHNRYVLGVRAAQLHHQHHHQLLLPGLLRSLQDLHEEMACILKEILQEYLEISSLVQDE
Sbjct: 181 AHHNRYVLGVRAAQLHHQHHHQLLLPGLLRSLQDLHEEMACILKEILQEYLEISSLVQDE 240

Query: 241 VVAIHREMAAAAARIQPEAEYQGFLRQYGSAPDVPPCVTFDESLLEEGEPLEPGELQLNE 300
           VVAIHREMAAAAARIQPEAEYQGFLRQYGSAPDVPPCVTFDESLLEEGEPLEPGELQLNE
Sbjct: 241 VVAIHREMAAAAARIQPEAEYQGFLRQYGSAPDVPPCVTFDESLLEEGEPLEPGELQLNE 300

Query: 301 LTVESVQHTLTSVTDELAVATEMVFRRQEMVTQLQQELRNEEENTHPRERVQLLGKRQVL 360
           LTVESVQHTLTSVTDELAVATEMVFRRQEMVTQLQQELRNEEENTHPRERVQLLGKRQVL
Sbjct: 301 LTVESVQHTLTSVTDELAVATEMVFRRQEMVTQLQQELRNEEENTHPRERVQLLGKRQVL 360

Query: 361 QEALQGLQVALCSQAK-------LQAQQE-----------LLQTKLEHLGPGE------- 395
           QEALQGLQVALCSQAK       LQ + E           LLQ         E       
Sbjct: 361 QEALQGLQVALCSQAKLQAQQELLQTKLEHLGPGEPPPVLLLQDDRHSTSSSEQEREGGR 420

Query: 396 ---------------------PPPVLLLQDDR-----------------------HSTSS 411
                                PPP+ L+ + +                       HS   
Sbjct: 421 TPTLEILKSHISGIFRPKFSLPPPLQLIPEVQKPLHEQLWYHGAIPRAEVAELLVHSGDF 480

Query: 412 SEQEREGGRTPTLEILKSHISGIFR-PKFSNLYRLEGEGFPSIPLLIDHLLSTQQPLTKK 470
             +E +G +   L +L   +   F      NLYRLEGEGFPSIPLLIDHLLSTQQPLTKK
Sbjct: 481 LVRESQGKQEYVLSVLWDGLPRHFIIQSLDNLYRLEGEGFPSIPLLIDHLLSTQQPLTKK 540

Query: 471 SGVVLHRAVPKDKWVLNHEDLVLGEQIGRGNFGEVFSGRLRADNTLVAVKSCRETLPPDL 530
           SGVVLHRAVPKDKWVLNHEDLVLGEQIGRGNFGEVFSGRLRADNTLVAVKSCRETLPPDL
Sbjct: 541 SGVVLHRAVPKDKWVLNHEDLVLGEQIGRGNFGEVFSGRLRADNTLVAVKSCRETLPPDL 600

Query: 531 KAKFLQEARILKQYSHPNIVRLIGVCTQKQPIYIVMELVQGGDFLTFLRTEGARLRVKTL 590
           KAKFLQEARILKQYSHPNIVRLIGVCTQKQPIYIVMELVQGGDFLTFLRTEGARLRVKTL
Sbjct: 601 KAKFLQEARILKQYSHPNIVRLIGVCTQKQPIYIVMELVQGGDFLTFLRTEGARLRVKTL 660

Query: 591 LQMVGDAAAGMEYLESKCCIHRDLAARNCLVTEKNVLKISDFGMSREEADGVYAASGGLR 650
           LQMVGDAAAGMEYLESKCCIHRDLAARNCLVTEKNVLKISDFGMSREEADGVYAASGGLR
Sbjct: 661 LQMVGDAAAGMEYLESKCCIHRDLAARNCLVTEKNVLKISDFGMSREEADGVYAASGGLR 720

Query: 651 QVPVKWTAPEALNYGRYSSESDVWSFGILLWETFSLGASPYPNLSNQQTREFVEKGGRLP 710
           QVPVKWTAPEALNYGRYSSESDVWSFGILLWETFSLGASPYPNLSNQQTREFVEKGGRLP
Sbjct: 721 QVPVKWTAPEALNYGRYSSESDVWSFGILLWETFSLGASPYPNLSNQQTREFVEKGGRLP 780

Query: 711 CPELCPDAVFRLMEQCWAYEPGQRPSFSTIYQELQSIRKRHR 752
           CPELCPDAVFRLMEQCWAYEPGQRPSFSTIYQELQSIRKRHR
Sbjct: 781 CPELCPDAVFRLMEQCWAYEPGQRPSFSTIYQELQSIRKRHR 822


>gi|219842236 feline sarcoma oncogene isoform 4 [Homo sapiens]
          Length = 694

 Score = 1246 bits (3225), Expect = 0.0
 Identities = 623/626 (99%), Positives = 626/626 (100%)

Query: 127 LTKTHSQDIEKLKSQYRALARDSAQAKRKYQEASKDKDRDKAKDKYVRSLWKLFAHHNRY 186
           +++THSQDIEKLKSQYRALARDSAQAKRKYQEASKDKDRDKAKDKYVRSLWKLFAHHNRY
Sbjct: 69  ISQTHSQDIEKLKSQYRALARDSAQAKRKYQEASKDKDRDKAKDKYVRSLWKLFAHHNRY 128

Query: 187 VLGVRAAQLHHQHHHQLLLPGLLRSLQDLHEEMACILKEILQEYLEISSLVQDEVVAIHR 246
           VLGVRAAQLHHQHHHQLLLPGLLRSLQDLHEEMACILKEILQEYLEISSLVQDEVVAIHR
Sbjct: 129 VLGVRAAQLHHQHHHQLLLPGLLRSLQDLHEEMACILKEILQEYLEISSLVQDEVVAIHR 188

Query: 247 EMAAAAARIQPEAEYQGFLRQYGSAPDVPPCVTFDESLLEEGEPLEPGELQLNELTVESV 306
           EMAAAAARIQPEAEYQGFLRQYGSAPDVPPCVTFDESLLEEGEPLEPGELQLNELTVESV
Sbjct: 189 EMAAAAARIQPEAEYQGFLRQYGSAPDVPPCVTFDESLLEEGEPLEPGELQLNELTVESV 248

Query: 307 QHTLTSVTDELAVATEMVFRRQEMVTQLQQELRNEEENTHPRERVQLLGKRQVLQEALQG 366
           QHTLTSVTDELAVATEMVFRRQEMVTQLQQELRNEEENTHPRERVQLLGKRQVLQEALQG
Sbjct: 249 QHTLTSVTDELAVATEMVFRRQEMVTQLQQELRNEEENTHPRERVQLLGKRQVLQEALQG 308

Query: 367 LQVALCSQAKLQAQQELLQTKLEHLGPGEPPPVLLLQDDRHSTSSSEQEREGGRTPTLEI 426
           LQVALCSQAKLQAQQELLQTKLEHLGPGEPPPVLLLQDDRHSTSSSEQEREGGRTPTLEI
Sbjct: 309 LQVALCSQAKLQAQQELLQTKLEHLGPGEPPPVLLLQDDRHSTSSSEQEREGGRTPTLEI 368

Query: 427 LKSHISGIFRPKFSNLYRLEGEGFPSIPLLIDHLLSTQQPLTKKSGVVLHRAVPKDKWVL 486
           LKSHISGIFRPKFSNLYRLEGEGFPSIPLLIDHLLSTQQPLTKKSGVVLHRAVPKDKWVL
Sbjct: 369 LKSHISGIFRPKFSNLYRLEGEGFPSIPLLIDHLLSTQQPLTKKSGVVLHRAVPKDKWVL 428

Query: 487 NHEDLVLGEQIGRGNFGEVFSGRLRADNTLVAVKSCRETLPPDLKAKFLQEARILKQYSH 546
           NHEDLVLGEQIGRGNFGEVFSGRLRADNTLVAVKSCRETLPPDLKAKFLQEARILKQYSH
Sbjct: 429 NHEDLVLGEQIGRGNFGEVFSGRLRADNTLVAVKSCRETLPPDLKAKFLQEARILKQYSH 488

Query: 547 PNIVRLIGVCTQKQPIYIVMELVQGGDFLTFLRTEGARLRVKTLLQMVGDAAAGMEYLES 606
           PNIVRLIGVCTQKQPIYIVMELVQGGDFLTFLRTEGARLRVKTLLQMVGDAAAGMEYLES
Sbjct: 489 PNIVRLIGVCTQKQPIYIVMELVQGGDFLTFLRTEGARLRVKTLLQMVGDAAAGMEYLES 548

Query: 607 KCCIHRDLAARNCLVTEKNVLKISDFGMSREEADGVYAASGGLRQVPVKWTAPEALNYGR 666
           KCCIHRDLAARNCLVTEKNVLKISDFGMSREEADGVYAASGGLRQVPVKWTAPEALNYGR
Sbjct: 549 KCCIHRDLAARNCLVTEKNVLKISDFGMSREEADGVYAASGGLRQVPVKWTAPEALNYGR 608

Query: 667 YSSESDVWSFGILLWETFSLGASPYPNLSNQQTREFVEKGGRLPCPELCPDAVFRLMEQC 726
           YSSESDVWSFGILLWETFSLGASPYPNLSNQQTREFVEKGGRLPCPELCPDAVFRLMEQC
Sbjct: 609 YSSESDVWSFGILLWETFSLGASPYPNLSNQQTREFVEKGGRLPCPELCPDAVFRLMEQC 668

Query: 727 WAYEPGQRPSFSTIYQELQSIRKRHR 752
           WAYEPGQRPSFSTIYQELQSIRKRHR
Sbjct: 669 WAYEPGQRPSFSTIYQELQSIRKRHR 694


>gi|219842230 feline sarcoma oncogene isoform 2 [Homo sapiens]
          Length = 764

 Score = 1097 bits (2837), Expect = 0.0
 Identities = 577/696 (82%), Positives = 590/696 (84%), Gaps = 70/696 (10%)

Query: 127 LTKTHSQDIEKLKSQYRALARDSAQAKRKYQEASKDKDRDKAKDKYVRSLWKLFAHHNRY 186
           +++THSQDIEKLKSQYRALARDSAQAKRKYQEASKDKDRDKAKDKYVRSLWKLFAHHNRY
Sbjct: 69  ISQTHSQDIEKLKSQYRALARDSAQAKRKYQEASKDKDRDKAKDKYVRSLWKLFAHHNRY 128

Query: 187 VLGVRAAQLHHQHHHQLLLPGLLRSLQDLHEEMACILKEILQEYLEISSLVQDEVVAIHR 246
           VLGVRAAQLHHQHHHQLLLPGLLRSLQDLHEEMACILKEILQEYLEISSLVQDEVVAIHR
Sbjct: 129 VLGVRAAQLHHQHHHQLLLPGLLRSLQDLHEEMACILKEILQEYLEISSLVQDEVVAIHR 188

Query: 247 EMAAAAARIQPEAEYQGFLRQYGSAPDVPPCVTFDESLLEEGEPLEPGELQLNELTVESV 306
           EMAAAAARIQPEAEYQGFLRQYGSAPDVPPCVTFDESLLEEGEPLEPGELQLNELTVESV
Sbjct: 189 EMAAAAARIQPEAEYQGFLRQYGSAPDVPPCVTFDESLLEEGEPLEPGELQLNELTVESV 248

Query: 307 QHTLTSVTDELAVATEMVFRRQEMVTQLQQELRNEEENTHPRERVQLLGKRQVLQEALQG 366
           QHTLTSVTDELAVATEMVFRRQEMVTQLQQELRNEEENTHPRERVQLLGKRQVLQEALQG
Sbjct: 249 QHTLTSVTDELAVATEMVFRRQEMVTQLQQELRNEEENTHPRERVQLLGKRQVLQEALQG 308

Query: 367 LQVALCSQAK-------LQAQQE-----------LLQTKLEHLGPGE------------- 395
           LQVALCSQAK       LQ + E           LLQ         E             
Sbjct: 309 LQVALCSQAKLQAQQELLQTKLEHLGPGEPPPVLLLQDDRHSTSSSEQEREGGRTPTLEI 368

Query: 396 ---------------PPPVLLLQDDR-----------------------HSTSSSEQERE 417
                          PPP+ L+ + +                       HS     +E +
Sbjct: 369 LKSHISGIFRPKFSLPPPLQLIPEVQKPLHEQLWYHGAIPRAEVAELLVHSGDFLVRESQ 428

Query: 418 GGRTPTLEILKSHISGIFR-PKFSNLYRLEGEGFPSIPLLIDHLLSTQQPLTKKSGVVLH 476
           G +   L +L   +   F      NLYRLEGEGFPSIPLLIDHLLSTQQPLTKKSGVVLH
Sbjct: 429 GKQEYVLSVLWDGLPRHFIIQSLDNLYRLEGEGFPSIPLLIDHLLSTQQPLTKKSGVVLH 488

Query: 477 RAVPKDKWVLNHEDLVLGEQIGRGNFGEVFSGRLRADNTLVAVKSCRETLPPDLKAKFLQ 536
           RAVPKDKWVLNHEDLVLGEQIGRGNFGEVFSGRLRADNTLVAVKSCRETLPPDLKAKFLQ
Sbjct: 489 RAVPKDKWVLNHEDLVLGEQIGRGNFGEVFSGRLRADNTLVAVKSCRETLPPDLKAKFLQ 548

Query: 537 EARILKQYSHPNIVRLIGVCTQKQPIYIVMELVQGGDFLTFLRTEGARLRVKTLLQMVGD 596
           EARILKQYSHPNIVRLIGVCTQKQPIYIVMELVQGGDFLTFLRTEGARLRVKTLLQMVGD
Sbjct: 549 EARILKQYSHPNIVRLIGVCTQKQPIYIVMELVQGGDFLTFLRTEGARLRVKTLLQMVGD 608

Query: 597 AAAGMEYLESKCCIHRDLAARNCLVTEKNVLKISDFGMSREEADGVYAASGGLRQVPVKW 656
           AAAGMEYLESKCCIHRDLAARNCLVTEKNVLKISDFGMSREEADGVYAASGGLRQVPVKW
Sbjct: 609 AAAGMEYLESKCCIHRDLAARNCLVTEKNVLKISDFGMSREEADGVYAASGGLRQVPVKW 668

Query: 657 TAPEALNYGRYSSESDVWSFGILLWETFSLGASPYPNLSNQQTREFVEKGGRLPCPELCP 716
           TAPEALNYGRYSSESDVWSFGILLWETFSLGASPYPNLSNQQTREFVEKGGRLPCPELCP
Sbjct: 669 TAPEALNYGRYSSESDVWSFGILLWETFSLGASPYPNLSNQQTREFVEKGGRLPCPELCP 728

Query: 717 DAVFRLMEQCWAYEPGQRPSFSTIYQELQSIRKRHR 752
           DAVFRLMEQCWAYEPGQRPSFSTIYQELQSIRKRHR
Sbjct: 729 DAVFRLMEQCWAYEPGQRPSFSTIYQELQSIRKRHR 764


>gi|119964721 fer (fps/fes related) tyrosine kinase [Homo sapiens]
          Length = 822

 Score =  580 bits (1494), Expect = e-165
 Identities = 348/829 (41%), Positives = 495/829 (59%), Gaps = 88/829 (10%)

Query: 1   MGFSSELCSPQGHGVLQQMQEAELRLLEGMRKWMAQRVKSDREYAGLLHHMSLQDSGGQS 60
           MGF S+L     H  + ++Q+ ELRLLE ++K+MA R+KSD+EYA  L ++  Q     +
Sbjct: 1   MGFGSDL--KNSHEAVLKLQDWELRLLETVKKFMALRIKSDKEYASTLQNLCNQVDKEST 58

Query: 61  RAISPDSPISQSWAEITSQTEGLSRLLRQHAEDLNSGPLSKLSLLIRERQQLRKTYSEQW 120
             ++  S +S+SW  +  QTE LSR+++ HAEDLNSGPL +L+++I+++QQ++K+Y    
Sbjct: 59  VQMNYVSNVSKSWLLMIQQTEQLSRIMKTHAEDLNSGPLHRLTMMIKDKQQVKKSYIGVH 118

Query: 121 QQLQQELTKTHSQDIEKLKSQYRALARDSAQAKRKYQEA-SKDKDRDKAKDKYVRSLWKL 179
           QQ++ E+ K    ++EKLK  YR L ++   AK KY+EA +K K+ +KAK++Y ++  KL
Sbjct: 119 QQIEAEMIKVTKTELEKLKCSYRQLIKEMNSAKEKYKEALAKGKETEKAKERYDKATMKL 178

Query: 180 FAHHNRYVLGVRAAQLHHQHHHQLLLPGLLRSLQDLHEEM---------------ACILK 224
              HN+YVL ++ AQLH   ++ + LP LL SLQ + EEM               + + +
Sbjct: 179 HMLHNQYVLALKGAQLHQNQYYDITLPLLLDSLQKMQEEMIKALKGIFDEYSQITSLVTE 238

Query: 225 EILQEYLEISSLVQ--------DEVVAIHREMAAAAARIQPEAEYQGFLRQYGSAPDVPP 276
           EI+  + EI   V+        +  + +HR  AA     + E E+   L +         
Sbjct: 239 EIVNVHKEIQMSVEQIDPSTEYNNFIDVHRTTAAK----EQEIEFDTSLLEENENLQANE 294

Query: 277 CV--------------TFDESLLEEGEPL---EPGELQLNELTVESVQHTLTSVTDELAV 319
            +              T  E L++  + L   E   L+L E  +E    T    +D + +
Sbjct: 295 IMWNNLTAESLQVMLKTLAEELMQTQQMLLNKEEAVLEL-EKRIEESSETCEKKSDIVLL 353

Query: 320 ------------------ATEMVFRRQ-EMVTQLQQE--------LRNEEENTHP---RE 349
                              TE  F  Q E++ Q  QE        + N EE+       E
Sbjct: 354 LSQKQALEELKQSVQQLRCTEAKFSAQKELLEQKVQENDGKEPPPVVNYEEDARSVTSME 413

Query: 350 RVQLLGKRQVLQEALQGLQVALCSQAKLQAQQELLQTKLEHLGPGEPPPVLLLQDDRHST 409
           R + L K + ++ ++ G+  +  S     A  +++    + L   +     + + +    
Sbjct: 414 RKERLSKFESIRHSIAGIIRSPKSALGSSALSDMISISEKPLAEQDWYHGAIPRIEAQEL 473

Query: 410 SSSEQE---REGGRTPTLEILKSHISGIFR----PKFSNLYRLEGEGFPSIPLLIDHLLS 462
              + +   RE    P   +L  +  G  R        N+YR EG GF +IP LIDH  +
Sbjct: 474 LKKQGDFLVRESHGKPGEYVLSVYSDGQRRHFIIQYVDNMYRFEGTGFSNIPQLIDHHYT 533

Query: 463 TQQPLTKKSGVVLHRAVPKDK-WVLNHEDLVLGEQIGRGNFGEVFSGRLRADNTLVAVKS 521
           T+Q +TKKSGVVL   +PKDK W+L+HED++LGE +G+GNFGEV+ G L+ D T VAVK+
Sbjct: 534 TKQVITKKSGVVLLNPIPKDKKWILSHEDVILGELLGKGNFGEVYKGTLK-DKTSVAVKT 592

Query: 522 CRETLPPDLKAKFLQEARILKQYSHPNIVRLIGVCTQKQPIYIVMELVQGGDFLTFLRTE 581
           C+E LP +LK KFLQEA+ILKQY HPNIV+LIGVCTQ+QP+YI+MELV GGDFLTFLR +
Sbjct: 593 CKEDLPQELKIKFLQEAKILKQYDHPNIVKLIGVCTQRQPVYIIMELVSGGDFLTFLRRK 652

Query: 582 GARLRVKTLLQMVGDAAAGMEYLESKCCIHRDLAARNCLVTEKNVLKISDFGMSREEADG 641
              L++K L++   DAAAGM YLESK CIHRDLAARNCLV E NVLKISDFGMSR+E  G
Sbjct: 653 KDELKLKQLVKFSLDAAAGMLYLESKNCIHRDLAARNCLVGENNVLKISDFGMSRQEDGG 712

Query: 642 VYAASGGLRQVPVKWTAPEALNYGRYSSESDVWSFGILLWETFSLGASPYPNLSNQQTRE 701
           VY++S GL+Q+P+KWTAPEALNYGRYSSESDVWSFGILLWETFSLG  PYP ++NQQ RE
Sbjct: 713 VYSSS-GLKQIPIKWTAPEALNYGRYSSESDVWSFGILLWETFSLGVCPYPGMTNQQARE 771

Query: 702 FVEKGGRLPCPELCPDAVFRLMEQCWAYEPGQRPSFSTIYQELQSIRKR 750
            VE+G R+  P+ CP+ + ++M +CW Y+P  RP FS + +EL  I+++
Sbjct: 772 QVERGYRMSAPQHCPEDISKIMMKCWDYKPENRPKFSELQKELTIIKRK 820


>gi|62362414 c-abl oncogene 1, receptor tyrosine kinase isoform a
           [Homo sapiens]
          Length = 1130

 Score =  238 bits (607), Expect = 2e-62
 Identities = 121/294 (41%), Positives = 183/294 (62%), Gaps = 8/294 (2%)

Query: 458 DHLLST-QQPLTKKSGVVLHRAVPK-DKWVLNHEDLVLGEQIGRGNFGEVFSGRLRADNT 515
           D L++T   P  K++   ++   P  DKW +   D+ +  ++G G +GEV+ G  +  + 
Sbjct: 207 DGLITTLHYPAPKRNKPTVYGVSPNYDKWEMERTDITMKHKLGGGQYGEVYEGVWKKYSL 266

Query: 516 LVAVKSCRE-TLPPDLKAKFLQEARILKQYSHPNIVRLIGVCTQKQPIYIVMELVQGGDF 574
            VAVK+ +E T+  +   +FL+EA ++K+  HPN+V+L+GVCT++ P YI+ E +  G+ 
Sbjct: 267 TVAVKTLKEDTMEVE---EFLKEAAVMKEIKHPNLVQLLGVCTREPPFYIITEFMTYGNL 323

Query: 575 LTFLRT-EGARLRVKTLLQMVGDAAAGMEYLESKCCIHRDLAARNCLVTEKNVLKISDFG 633
           L +LR      +    LL M    ++ MEYLE K  IHRDLAARNCLV E +++K++DFG
Sbjct: 324 LDYLRECNRQEVNAVVLLYMATQISSAMEYLEKKNFIHRDLAARNCLVGENHLVKVADFG 383

Query: 634 MSREEADGVYAASGGLRQVPVKWTAPEALNYGRYSSESDVWSFGILLWETFSLGASPYPN 693
           +SR      Y A  G +  P+KWTAPE+L Y ++S +SDVW+FG+LLWE  + G SPYP 
Sbjct: 384 LSRLMTGDTYTAHAGAK-FPIKWTAPESLAYNKFSIKSDVWAFGVLLWEIATYGMSPYPG 442

Query: 694 LSNQQTREFVEKGGRLPCPELCPDAVFRLMEQCWAYEPGQRPSFSTIYQELQSI 747
           +   Q  E +EK  R+  PE CP+ V+ LM  CW + P  RPSF+ I+Q  +++
Sbjct: 443 IDLSQVYELLEKDYRMERPEGCPEKVYELMRACWQWNPSDRPSFAEIHQAFETM 496


>gi|62362412 c-abl oncogene 1, receptor tyrosine kinase isoform b
           [Homo sapiens]
          Length = 1149

 Score =  238 bits (607), Expect = 2e-62
 Identities = 121/294 (41%), Positives = 183/294 (62%), Gaps = 8/294 (2%)

Query: 458 DHLLST-QQPLTKKSGVVLHRAVPK-DKWVLNHEDLVLGEQIGRGNFGEVFSGRLRADNT 515
           D L++T   P  K++   ++   P  DKW +   D+ +  ++G G +GEV+ G  +  + 
Sbjct: 226 DGLITTLHYPAPKRNKPTVYGVSPNYDKWEMERTDITMKHKLGGGQYGEVYEGVWKKYSL 285

Query: 516 LVAVKSCRE-TLPPDLKAKFLQEARILKQYSHPNIVRLIGVCTQKQPIYIVMELVQGGDF 574
            VAVK+ +E T+  +   +FL+EA ++K+  HPN+V+L+GVCT++ P YI+ E +  G+ 
Sbjct: 286 TVAVKTLKEDTMEVE---EFLKEAAVMKEIKHPNLVQLLGVCTREPPFYIITEFMTYGNL 342

Query: 575 LTFLRT-EGARLRVKTLLQMVGDAAAGMEYLESKCCIHRDLAARNCLVTEKNVLKISDFG 633
           L +LR      +    LL M    ++ MEYLE K  IHRDLAARNCLV E +++K++DFG
Sbjct: 343 LDYLRECNRQEVNAVVLLYMATQISSAMEYLEKKNFIHRDLAARNCLVGENHLVKVADFG 402

Query: 634 MSREEADGVYAASGGLRQVPVKWTAPEALNYGRYSSESDVWSFGILLWETFSLGASPYPN 693
           +SR      Y A  G +  P+KWTAPE+L Y ++S +SDVW+FG+LLWE  + G SPYP 
Sbjct: 403 LSRLMTGDTYTAHAGAK-FPIKWTAPESLAYNKFSIKSDVWAFGVLLWEIATYGMSPYPG 461

Query: 694 LSNQQTREFVEKGGRLPCPELCPDAVFRLMEQCWAYEPGQRPSFSTIYQELQSI 747
           +   Q  E +EK  R+  PE CP+ V+ LM  CW + P  RPSF+ I+Q  +++
Sbjct: 462 IDLSQVYELLEKDYRMERPEGCPEKVYELMRACWQWNPSDRPSFAEIHQAFETM 515


>gi|153266778 arg tyrosine kinase isoform c [Homo sapiens]
          Length = 1167

 Score =  232 bits (591), Expect = 1e-60
 Identities = 116/268 (43%), Positives = 168/268 (62%), Gaps = 6/268 (2%)

Query: 482 DKWVLNHEDLVLGEQIGRGNFGEVFSGRLRADNTLVAVKSCRE-TLPPDLKAKFLQEARI 540
           DKW +   D+ +  ++G G +GEV+ G  +  +  VAVK+ +E T+  +   +FL+EA +
Sbjct: 264 DKWEMERTDITMKHKLGGGQYGEVYVGVWKKYSLTVAVKTLKEDTMEVE---EFLKEAAV 320

Query: 541 LKQYSHPNIVRLIGVCTQKQPIYIVMELVQGGDFLTFLRT-EGARLRVKTLLQMVGDAAA 599
           +K+  HPN+V+L+GVCT + P YIV E +  G+ L +LR      +    LL M    ++
Sbjct: 321 MKEIKHPNLVQLLGVCTLEPPFYIVTEYMPYGNLLDYLRECNREEVTAVVLLYMATQISS 380

Query: 600 GMEYLESKCCIHRDLAARNCLVTEKNVLKISDFGMSREEADGVYAASGGLRQVPVKWTAP 659
            MEYLE K  IHRDLAARNCLV E +V+K++DFG+SR      Y A  G +  P+KWTAP
Sbjct: 381 AMEYLEKKNFIHRDLAARNCLVGENHVVKVADFGLSRLMTGDTYTAHAGAK-FPIKWTAP 439

Query: 660 EALNYGRYSSESDVWSFGILLWETFSLGASPYPNLSNQQTREFVEKGGRLPCPELCPDAV 719
           E+L Y  +S +SDVW+FG+LLWE  + G SPYP +   Q  + +EKG R+  PE CP  V
Sbjct: 440 ESLAYNTFSIKSDVWAFGVLLWEIATYGMSPYPGIDLSQVYDLLEKGYRMEQPEGCPPKV 499

Query: 720 FRLMEQCWAYEPGQRPSFSTIYQELQSI 747
           + LM  CW + P  RPSF+  +Q  +++
Sbjct: 500 YELMRACWKWSPADRPSFAETHQAFETM 527


>gi|6382062 arg tyrosine kinase isoform b [Homo sapiens]
          Length = 1182

 Score =  232 bits (591), Expect = 1e-60
 Identities = 116/268 (43%), Positives = 168/268 (62%), Gaps = 6/268 (2%)

Query: 482 DKWVLNHEDLVLGEQIGRGNFGEVFSGRLRADNTLVAVKSCRE-TLPPDLKAKFLQEARI 540
           DKW +   D+ +  ++G G +GEV+ G  +  +  VAVK+ +E T+  +   +FL+EA +
Sbjct: 279 DKWEMERTDITMKHKLGGGQYGEVYVGVWKKYSLTVAVKTLKEDTMEVE---EFLKEAAV 335

Query: 541 LKQYSHPNIVRLIGVCTQKQPIYIVMELVQGGDFLTFLRT-EGARLRVKTLLQMVGDAAA 599
           +K+  HPN+V+L+GVCT + P YIV E +  G+ L +LR      +    LL M    ++
Sbjct: 336 MKEIKHPNLVQLLGVCTLEPPFYIVTEYMPYGNLLDYLRECNREEVTAVVLLYMATQISS 395

Query: 600 GMEYLESKCCIHRDLAARNCLVTEKNVLKISDFGMSREEADGVYAASGGLRQVPVKWTAP 659
            MEYLE K  IHRDLAARNCLV E +V+K++DFG+SR      Y A  G +  P+KWTAP
Sbjct: 396 AMEYLEKKNFIHRDLAARNCLVGENHVVKVADFGLSRLMTGDTYTAHAGAK-FPIKWTAP 454

Query: 660 EALNYGRYSSESDVWSFGILLWETFSLGASPYPNLSNQQTREFVEKGGRLPCPELCPDAV 719
           E+L Y  +S +SDVW+FG+LLWE  + G SPYP +   Q  + +EKG R+  PE CP  V
Sbjct: 455 ESLAYNTFSIKSDVWAFGVLLWEIATYGMSPYPGIDLSQVYDLLEKGYRMEQPEGCPPKV 514

Query: 720 FRLMEQCWAYEPGQRPSFSTIYQELQSI 747
           + LM  CW + P  RPSF+  +Q  +++
Sbjct: 515 YELMRACWKWSPADRPSFAETHQAFETM 542


>gi|209862778 arg tyrosine kinase isoform e [Homo sapiens]
          Length = 542

 Score =  232 bits (591), Expect = 1e-60
 Identities = 116/268 (43%), Positives = 168/268 (62%), Gaps = 6/268 (2%)

Query: 482 DKWVLNHEDLVLGEQIGRGNFGEVFSGRLRADNTLVAVKSCRE-TLPPDLKAKFLQEARI 540
           DKW +   D+ +  ++G G +GEV+ G  +  +  VAVK+ +E T+  +   +FL+EA +
Sbjct: 258 DKWEMERTDITMKHKLGGGQYGEVYVGVWKKYSLTVAVKTLKEDTMEVE---EFLKEAAV 314

Query: 541 LKQYSHPNIVRLIGVCTQKQPIYIVMELVQGGDFLTFLRT-EGARLRVKTLLQMVGDAAA 599
           +K+  HPN+V+L+GVCT + P YIV E +  G+ L +LR      +    LL M    ++
Sbjct: 315 MKEIKHPNLVQLLGVCTLEPPFYIVTEYMPYGNLLDYLRECNREEVTAVVLLYMATQISS 374

Query: 600 GMEYLESKCCIHRDLAARNCLVTEKNVLKISDFGMSREEADGVYAASGGLRQVPVKWTAP 659
            MEYLE K  IHRDLAARNCLV E +V+K++DFG+SR      Y A  G +  P+KWTAP
Sbjct: 375 AMEYLEKKNFIHRDLAARNCLVGENHVVKVADFGLSRLMTGDTYTAHAGAK-FPIKWTAP 433

Query: 660 EALNYGRYSSESDVWSFGILLWETFSLGASPYPNLSNQQTREFVEKGGRLPCPELCPDAV 719
           E+L Y  +S +SDVW+FG+LLWE  + G SPYP +   Q  + +EKG R+  PE CP  V
Sbjct: 434 ESLAYNTFSIKSDVWAFGVLLWEIATYGMSPYPGIDLSQVYDLLEKGYRMEQPEGCPPKV 493

Query: 720 FRLMEQCWAYEPGQRPSFSTIYQELQSI 747
           + LM  CW + P  RPSF+  +Q  +++
Sbjct: 494 YELMRACWKWSPADRPSFAETHQAFETM 521


>gi|209862772 arg tyrosine kinase isoform d [Homo sapiens]
          Length = 1064

 Score =  232 bits (591), Expect = 1e-60
 Identities = 116/268 (43%), Positives = 168/268 (62%), Gaps = 6/268 (2%)

Query: 482 DKWVLNHEDLVLGEQIGRGNFGEVFSGRLRADNTLVAVKSCRE-TLPPDLKAKFLQEARI 540
           DKW +   D+ +  ++G G +GEV+ G  +  +  VAVK+ +E T+  +   +FL+EA +
Sbjct: 264 DKWEMERTDITMKHKLGGGQYGEVYVGVWKKYSLTVAVKTLKEDTMEVE---EFLKEAAV 320

Query: 541 LKQYSHPNIVRLIGVCTQKQPIYIVMELVQGGDFLTFLRT-EGARLRVKTLLQMVGDAAA 599
           +K+  HPN+V+L+GVCT + P YIV E +  G+ L +LR      +    LL M    ++
Sbjct: 321 MKEIKHPNLVQLLGVCTLEPPFYIVTEYMPYGNLLDYLRECNREEVTAVVLLYMATQISS 380

Query: 600 GMEYLESKCCIHRDLAARNCLVTEKNVLKISDFGMSREEADGVYAASGGLRQVPVKWTAP 659
            MEYLE K  IHRDLAARNCLV E +V+K++DFG+SR      Y A  G +  P+KWTAP
Sbjct: 381 AMEYLEKKNFIHRDLAARNCLVGENHVVKVADFGLSRLMTGDTYTAHAGAK-FPIKWTAP 439

Query: 660 EALNYGRYSSESDVWSFGILLWETFSLGASPYPNLSNQQTREFVEKGGRLPCPELCPDAV 719
           E+L Y  +S +SDVW+FG+LLWE  + G SPYP +   Q  + +EKG R+  PE CP  V
Sbjct: 440 ESLAYNTFSIKSDVWAFGVLLWEIATYGMSPYPGIDLSQVYDLLEKGYRMEQPEGCPPKV 499

Query: 720 FRLMEQCWAYEPGQRPSFSTIYQELQSI 747
           + LM  CW + P  RPSF+  +Q  +++
Sbjct: 500 YELMRACWKWSPADRPSFAETHQAFETM 527


>gi|153266757 arg tyrosine kinase isoform a [Homo sapiens]
          Length = 1146

 Score =  232 bits (591), Expect = 1e-60
 Identities = 116/268 (43%), Positives = 168/268 (62%), Gaps = 6/268 (2%)

Query: 482 DKWVLNHEDLVLGEQIGRGNFGEVFSGRLRADNTLVAVKSCRE-TLPPDLKAKFLQEARI 540
           DKW +   D+ +  ++G G +GEV+ G  +  +  VAVK+ +E T+  +   +FL+EA +
Sbjct: 243 DKWEMERTDITMKHKLGGGQYGEVYVGVWKKYSLTVAVKTLKEDTMEVE---EFLKEAAV 299

Query: 541 LKQYSHPNIVRLIGVCTQKQPIYIVMELVQGGDFLTFLRT-EGARLRVKTLLQMVGDAAA 599
           +K+  HPN+V+L+GVCT + P YIV E +  G+ L +LR      +    LL M    ++
Sbjct: 300 MKEIKHPNLVQLLGVCTLEPPFYIVTEYMPYGNLLDYLRECNREEVTAVVLLYMATQISS 359

Query: 600 GMEYLESKCCIHRDLAARNCLVTEKNVLKISDFGMSREEADGVYAASGGLRQVPVKWTAP 659
            MEYLE K  IHRDLAARNCLV E +V+K++DFG+SR      Y A  G +  P+KWTAP
Sbjct: 360 AMEYLEKKNFIHRDLAARNCLVGENHVVKVADFGLSRLMTGDTYTAHAGAK-FPIKWTAP 418

Query: 660 EALNYGRYSSESDVWSFGILLWETFSLGASPYPNLSNQQTREFVEKGGRLPCPELCPDAV 719
           E+L Y  +S +SDVW+FG+LLWE  + G SPYP +   Q  + +EKG R+  PE CP  V
Sbjct: 419 ESLAYNTFSIKSDVWAFGVLLWEIATYGMSPYPGIDLSQVYDLLEKGYRMEQPEGCPPKV 478

Query: 720 FRLMEQCWAYEPGQRPSFSTIYQELQSI 747
           + LM  CW + P  RPSF+  +Q  +++
Sbjct: 479 YELMRACWKWSPADRPSFAETHQAFETM 506


>gi|21450844 megakaryocyte-associated tyrosine kinase isoform c
           [Homo sapiens]
          Length = 466

 Score =  226 bits (577), Expect = 5e-59
 Identities = 123/262 (46%), Positives = 160/262 (61%), Gaps = 12/262 (4%)

Query: 484 WVLNHEDLVLGEQIGRGNFGEVFSGRLRADNTLVAVKSCRETLPPDLKAKFLQEARILKQ 543
           W+LN + L LG QIG G FG V  G        V    C  T        FL E  ++ +
Sbjct: 187 WLLNLQHLTLGAQIGEGEFGAVLQGEYLGQKVAVKNIKCDVTAQA-----FLDETAVMTK 241

Query: 544 YSHPNIVRLIGVCTQKQPIYIVMELVQGGDFLTFLRTEG-ARLRVKTLLQMVGDAAAGME 602
             H N+VRL+GV    Q +YIVME V  G+ + FLRT G A +    LLQ     A GME
Sbjct: 242 MQHENLVRLLGVILH-QGLYIVMEHVSKGNLVNFLRTRGRALVNTAQLLQFSLHVAEGME 300

Query: 603 YLESKCCIHRDLAARNCLVTEKNVLKISDFGMSREEADGVYAASGGLRQVPVKWTAPEAL 662
           YLESK  +HRDLAARN LV+E  V K+SDFG+++ E  G+ ++     ++PVKWTAPEAL
Sbjct: 301 YLESKKLVHRDLAARNILVSEDLVAKVSDFGLAKAERKGLDSS-----RLPVKWTAPEAL 355

Query: 663 NYGRYSSESDVWSFGILLWETFSLGASPYPNLSNQQTREFVEKGGRLPCPELCPDAVFRL 722
            +G+++S+SDVWSFG+LLWE FS G +PYP +S ++  E VEKG R+  PE CP  V  L
Sbjct: 356 KHGKFTSKSDVWSFGVLLWEVFSYGRAPYPKMSLKEVSEAVEKGYRMEPPEGCPGPVHVL 415

Query: 723 MEQCWAYEPGQRPSFSTIYQEL 744
           M  CW  EP +RP F  + ++L
Sbjct: 416 MSSCWEAEPARRPPFRKLAEKL 437


>gi|21450842 megakaryocyte-associated tyrosine kinase isoform b
           [Homo sapiens]
          Length = 508

 Score =  226 bits (577), Expect = 5e-59
 Identities = 123/262 (46%), Positives = 160/262 (61%), Gaps = 12/262 (4%)

Query: 484 WVLNHEDLVLGEQIGRGNFGEVFSGRLRADNTLVAVKSCRETLPPDLKAKFLQEARILKQ 543
           W+LN + L LG QIG G FG V  G        V    C  T        FL E  ++ +
Sbjct: 229 WLLNLQHLTLGAQIGEGEFGAVLQGEYLGQKVAVKNIKCDVTAQA-----FLDETAVMTK 283

Query: 544 YSHPNIVRLIGVCTQKQPIYIVMELVQGGDFLTFLRTEG-ARLRVKTLLQMVGDAAAGME 602
             H N+VRL+GV    Q +YIVME V  G+ + FLRT G A +    LLQ     A GME
Sbjct: 284 MQHENLVRLLGVILH-QGLYIVMEHVSKGNLVNFLRTRGRALVNTAQLLQFSLHVAEGME 342

Query: 603 YLESKCCIHRDLAARNCLVTEKNVLKISDFGMSREEADGVYAASGGLRQVPVKWTAPEAL 662
           YLESK  +HRDLAARN LV+E  V K+SDFG+++ E  G+ ++     ++PVKWTAPEAL
Sbjct: 343 YLESKKLVHRDLAARNILVSEDLVAKVSDFGLAKAERKGLDSS-----RLPVKWTAPEAL 397

Query: 663 NYGRYSSESDVWSFGILLWETFSLGASPYPNLSNQQTREFVEKGGRLPCPELCPDAVFRL 722
            +G+++S+SDVWSFG+LLWE FS G +PYP +S ++  E VEKG R+  PE CP  V  L
Sbjct: 398 KHGKFTSKSDVWSFGVLLWEVFSYGRAPYPKMSLKEVSEAVEKGYRMEPPEGCPGPVHVL 457

Query: 723 MEQCWAYEPGQRPSFSTIYQEL 744
           M  CW  EP +RP F  + ++L
Sbjct: 458 MSSCWEAEPARRPPFRKLAEKL 479


>gi|21450846 megakaryocyte-associated tyrosine kinase isoform a
           [Homo sapiens]
          Length = 507

 Score =  226 bits (577), Expect = 5e-59
 Identities = 123/262 (46%), Positives = 160/262 (61%), Gaps = 12/262 (4%)

Query: 484 WVLNHEDLVLGEQIGRGNFGEVFSGRLRADNTLVAVKSCRETLPPDLKAKFLQEARILKQ 543
           W+LN + L LG QIG G FG V  G        V    C  T        FL E  ++ +
Sbjct: 228 WLLNLQHLTLGAQIGEGEFGAVLQGEYLGQKVAVKNIKCDVTAQA-----FLDETAVMTK 282

Query: 544 YSHPNIVRLIGVCTQKQPIYIVMELVQGGDFLTFLRTEG-ARLRVKTLLQMVGDAAAGME 602
             H N+VRL+GV    Q +YIVME V  G+ + FLRT G A +    LLQ     A GME
Sbjct: 283 MQHENLVRLLGVILH-QGLYIVMEHVSKGNLVNFLRTRGRALVNTAQLLQFSLHVAEGME 341

Query: 603 YLESKCCIHRDLAARNCLVTEKNVLKISDFGMSREEADGVYAASGGLRQVPVKWTAPEAL 662
           YLESK  +HRDLAARN LV+E  V K+SDFG+++ E  G+ ++     ++PVKWTAPEAL
Sbjct: 342 YLESKKLVHRDLAARNILVSEDLVAKVSDFGLAKAERKGLDSS-----RLPVKWTAPEAL 396

Query: 663 NYGRYSSESDVWSFGILLWETFSLGASPYPNLSNQQTREFVEKGGRLPCPELCPDAVFRL 722
            +G+++S+SDVWSFG+LLWE FS G +PYP +S ++  E VEKG R+  PE CP  V  L
Sbjct: 397 KHGKFTSKSDVWSFGVLLWEVFSYGRAPYPKMSLKEVSEAVEKGYRMEPPEGCPGPVHVL 456

Query: 723 MEQCWAYEPGQRPSFSTIYQEL 744
           M  CW  EP +RP F  + ++L
Sbjct: 457 MSSCWEAEPARRPPFRKLAEKL 478


>gi|130977759 tec protein tyrosine kinase [Homo sapiens]
          Length = 631

 Score =  226 bits (575), Expect = 8e-59
 Identities = 124/314 (39%), Positives = 178/314 (56%), Gaps = 13/314 (4%)

Query: 443 YRLEGEGFPSIPLLIDH--------LLSTQQPLTKKS-GVVLHRAVPKDKWVLNHEDLVL 493
           Y  E   F SIP +I++        +   + P++ K            +KW +N  +L  
Sbjct: 313 YLAEKHAFGSIPEIIEYHKHNAAGLVTRLRYPVSVKGKNAPTTAGFSYEKWEINPSELTF 372

Query: 494 GEQIGRGNFGEVFSGRLRADNTLVAVKSCRETLPPDLKAKFLQEARILKQYSHPNIVRLI 553
             ++G G FG V  G+ RA    VA+K+ RE      +  F++EA+++ + +HP +V+L 
Sbjct: 373 MRELGSGLFGVVRLGKWRAQYK-VAIKAIREGAM--CEEDFIEEAKVMMKLTHPKLVQLY 429

Query: 554 GVCTQKQPIYIVMELVQGGDFLTFLRTEGARLRVKTLLQMVGDAAAGMEYLESKCCIHRD 613
           GVCTQ++PIYIV E ++ G  L FLR          LL M  D   GMEYLE    IHRD
Sbjct: 430 GVCTQQKPIYIVTEFMERGCLLNFLRQRQGHFSRDVLLSMCQDVCEGMEYLERNSFIHRD 489

Query: 614 LAARNCLVTEKNVLKISDFGMSREEADGVYAASGGLRQVPVKWTAPEALNYGRYSSESDV 673
           LAARNCLV+E  V+K+SDFGM+R   D  Y +S G +  PVKW  PE  NY R+SS+SDV
Sbjct: 490 LAARNCLVSEAGVVKVSDFGMARYVLDDQYTSSSGAK-FPVKWCPPEVFNYSRFSSKSDV 548

Query: 674 WSFGILLWETFSLGASPYPNLSNQQTREFVEKGGRLPCPELCPDAVFRLMEQCWAYEPGQ 733
           WSFG+L+WE F+ G  P+   +N +    V +G RL  P+L  + V+ +M +CW  +P  
Sbjct: 549 WSFGVLMWEVFTEGRMPFEKYTNYEVVTMVTRGHRLYQPKLASNYVYEVMLRCWQEKPEG 608

Query: 734 RPSFSTIYQELQSI 747
           RPSF  + + +  +
Sbjct: 609 RPSFEDLLRTIDEL 622


>gi|15718680 IL2-inducible T-cell kinase [Homo sapiens]
          Length = 620

 Score =  225 bits (573), Expect = 1e-58
 Identities = 118/266 (44%), Positives = 161/266 (60%), Gaps = 6/266 (2%)

Query: 483 KWVLNHEDLVLGEQIGRGNFGEVFSGR-LRADNTLVAVKSCRETLPPDLKAKFLQEARIL 541
           KWV++  +L   ++IG G FG V  G  L  D   VA+K+ RE    +    F++EA ++
Sbjct: 355 KWVIDPSELTFVQEIGSGQFGLVHLGYWLNKDK--VAIKTIREGAMSE--EDFIEEAEVM 410

Query: 542 KQYSHPNIVRLIGVCTQKQPIYIVMELVQGGDFLTFLRTEGARLRVKTLLQMVGDAAAGM 601
            + SHP +V+L GVC ++ PI +V E ++ G    +LRT+      +TLL M  D   GM
Sbjct: 411 MKLSHPKLVQLYGVCLEQAPICLVFEFMEHGCLSDYLRTQRGLFAAETLLGMCLDVCEGM 470

Query: 602 EYLESKCCIHRDLAARNCLVTEKNVLKISDFGMSREEADGVYAASGGLRQVPVKWTAPEA 661
            YLE  C IHRDLAARNCLV E  V+K+SDFGM+R   D  Y +S G +  PVKW +PE 
Sbjct: 471 AYLEEACVIHRDLAARNCLVGENQVIKVSDFGMTRFVLDDQYTSSTGTK-FPVKWASPEV 529

Query: 662 LNYGRYSSESDVWSFGILLWETFSLGASPYPNLSNQQTREFVEKGGRLPCPELCPDAVFR 721
            ++ RYSS+SDVWSFG+L+WE FS G  PY N SN +  E +  G RL  P L    V++
Sbjct: 530 FSFSRYSSKSDVWSFGVLMWEVFSEGKIPYENRSNSEVVEDISTGFRLYKPRLASTHVYQ 589

Query: 722 LMEQCWAYEPGQRPSFSTIYQELQSI 747
           +M  CW   P  RP+FS + ++L  I
Sbjct: 590 IMNHCWKERPEDRPAFSRLLRQLAEI 615


>gi|4502435 BMX non-receptor tyrosine kinase [Homo sapiens]
          Length = 675

 Score =  223 bits (569), Expect = 4e-58
 Identities = 127/323 (39%), Positives = 185/323 (57%), Gaps = 15/323 (4%)

Query: 440 SNLYRLEGEGFPSIPLLIDH--------LLSTQQPLTKKSGVVLHR-AVPKDKWVLNHED 490
           + LY  E   F SIP LI +        +   + P++ K+  V    ++    W L  E+
Sbjct: 357 NKLYLAENYCFDSIPKLIHYHQHNSAGMITRLRHPVSTKANKVPDSVSLGNGIWELKREE 416

Query: 491 LVLGEQIGRGNFGEVFSGRLRADNTLVAVKSCRE-TLPPDLKAKFLQEARILKQYSHPNI 549
           + L +++G G FG V  G+ +     VAVK  +E ++  D   +F QEA+ + + SHP +
Sbjct: 417 ITLLKELGSGQFGVVQLGKWKGQYD-VAVKMIKEGSMSED---EFFQEAQTMMKLSHPKL 472

Query: 550 VRLIGVCTQKQPIYIVMELVQGGDFLTFLRTEGARLRVKTLLQMVGDAAAGMEYLESKCC 609
           V+  GVC+++ PIYIV E +  G  L +LR+ G  L    LL+M  D   GM +LES   
Sbjct: 473 VKFYGVCSKEYPIYIVTEYISNGCLLNYLRSHGKGLEPSQLLEMCYDVCEGMAFLESHQF 532

Query: 610 IHRDLAARNCLVTEKNVLKISDFGMSREEADGVYAASGGLRQVPVKWTAPEALNYGRYSS 669
           IHRDLAARNCLV     +K+SDFGM+R   D  Y +S G +  PVKW+APE  +Y +YSS
Sbjct: 533 IHRDLAARNCLVDRDLCVKVSDFGMTRYVLDDQYVSSVGTK-FPVKWSAPEVFHYFKYSS 591

Query: 670 ESDVWSFGILLWETFSLGASPYPNLSNQQTREFVEKGGRLPCPELCPDAVFRLMEQCWAY 729
           +SDVW+FGIL+WE FSLG  PY    N Q    V +G RL  P L  D ++++M  CW  
Sbjct: 592 KSDVWAFGILMWEVFSLGKQPYDLYDNSQVVLKVSQGHRLYRPHLASDTIYQIMYSCWHE 651

Query: 730 EPGQRPSFSTIYQELQSIRKRHR 752
            P +RP+F  +   ++ +R++ +
Sbjct: 652 LPEKRPTFQQLLSSIEPLREKDK 674


>gi|42544182 BMX non-receptor tyrosine kinase [Homo sapiens]
          Length = 675

 Score =  223 bits (569), Expect = 4e-58
 Identities = 127/323 (39%), Positives = 185/323 (57%), Gaps = 15/323 (4%)

Query: 440 SNLYRLEGEGFPSIPLLIDH--------LLSTQQPLTKKSGVVLHR-AVPKDKWVLNHED 490
           + LY  E   F SIP LI +        +   + P++ K+  V    ++    W L  E+
Sbjct: 357 NKLYLAENYCFDSIPKLIHYHQHNSAGMITRLRHPVSTKANKVPDSVSLGNGIWELKREE 416

Query: 491 LVLGEQIGRGNFGEVFSGRLRADNTLVAVKSCRE-TLPPDLKAKFLQEARILKQYSHPNI 549
           + L +++G G FG V  G+ +     VAVK  +E ++  D   +F QEA+ + + SHP +
Sbjct: 417 ITLLKELGSGQFGVVQLGKWKGQYD-VAVKMIKEGSMSED---EFFQEAQTMMKLSHPKL 472

Query: 550 VRLIGVCTQKQPIYIVMELVQGGDFLTFLRTEGARLRVKTLLQMVGDAAAGMEYLESKCC 609
           V+  GVC+++ PIYIV E +  G  L +LR+ G  L    LL+M  D   GM +LES   
Sbjct: 473 VKFYGVCSKEYPIYIVTEYISNGCLLNYLRSHGKGLEPSQLLEMCYDVCEGMAFLESHQF 532

Query: 610 IHRDLAARNCLVTEKNVLKISDFGMSREEADGVYAASGGLRQVPVKWTAPEALNYGRYSS 669
           IHRDLAARNCLV     +K+SDFGM+R   D  Y +S G +  PVKW+APE  +Y +YSS
Sbjct: 533 IHRDLAARNCLVDRDLCVKVSDFGMTRYVLDDQYVSSVGTK-FPVKWSAPEVFHYFKYSS 591

Query: 670 ESDVWSFGILLWETFSLGASPYPNLSNQQTREFVEKGGRLPCPELCPDAVFRLMEQCWAY 729
           +SDVW+FGIL+WE FSLG  PY    N Q    V +G RL  P L  D ++++M  CW  
Sbjct: 592 KSDVWAFGILMWEVFSLGKQPYDLYDNSQVVLKVSQGHRLYRPHLASDTIYQIMYSCWHE 651

Query: 730 EPGQRPSFSTIYQELQSIRKRHR 752
            P +RP+F  +   ++ +R++ +
Sbjct: 652 LPEKRPTFQQLLSSIEPLREKDK 674


>gi|29029632 anaplastic lymphoma kinase [Homo sapiens]
          Length = 1620

 Score =  220 bits (561), Expect = 3e-57
 Identities = 116/271 (42%), Positives = 163/271 (60%), Gaps = 14/271 (5%)

Query: 489  EDLVLGEQIGRGNFGEVFSGRLRA-----DNTLVAVKSCRETLPPDLKAKFLQEARILKQ 543
            +++ L   +G G FGEV+ G++           VAVK+  E      +  FL EA I+ +
Sbjct: 1114 KNITLIRGLGHGAFGEVYEGQVSGMPNDPSPLQVAVKTLPEVCSEQDELDFLMEALIISK 1173

Query: 544  YSHPNIVRLIGVCTQKQPIYIVMELVQGGDFLTFLR------TEGARLRVKTLLQMVGDA 597
            ++H NIVR IGV  Q  P +I++EL+ GGD  +FLR      ++ + L +  LL +  D 
Sbjct: 1174 FNHQNIVRCIGVSLQSLPRFILLELMAGGDLKSFLRETRPRPSQPSSLAMLDLLHVARDI 1233

Query: 598  AAGMEYLESKCCIHRDLAARNCLVT---EKNVLKISDFGMSREEADGVYAASGGLRQVPV 654
            A G +YLE    IHRD+AARNCL+T      V KI DFGM+R+     Y   GG   +PV
Sbjct: 1234 ACGCQYLEENHFIHRDIAARNCLLTCPGPGRVAKIGDFGMARDIYRASYYRKGGCAMLPV 1293

Query: 655  KWTAPEALNYGRYSSESDVWSFGILLWETFSLGASPYPNLSNQQTREFVEKGGRLPCPEL 714
            KW  PEA   G ++S++D WSFG+LLWE FSLG  PYP+ SNQ+  EFV  GGR+  P+ 
Sbjct: 1294 KWMPPEAFMEGIFTSKTDTWSFGVLLWEIFSLGYMPYPSKSNQEVLEFVTSGGRMDPPKN 1353

Query: 715  CPDAVFRLMEQCWAYEPGQRPSFSTIYQELQ 745
            CP  V+R+M QCW ++P  RP+F+ I + ++
Sbjct: 1354 CPGPVYRIMTQCWQHQPEDRPNFAIILERIE 1384


>gi|148596974 TXK tyrosine kinase [Homo sapiens]
          Length = 527

 Score =  220 bits (561), Expect = 3e-57
 Identities = 133/377 (35%), Positives = 204/377 (54%), Gaps = 16/377 (4%)

Query: 381 QELLQTKLEHLGPGEPPP-VLLLQDDRHSTSSSEQEREGGRTPTLEILKSHISGIFRPKF 439
           + + + + EHL   E      +++D RH  S +     G R  T   +K +   I +   
Sbjct: 153 RNITRNQAEHLLRQESKEGAFIVRDSRHLGSYTISVFMGARRSTEAAIKHY--QIKKNDS 210

Query: 440 SNLYRLEGEGFPSIPLLI---DHLLSTQQPLTKKSGVVLHRAVPK------DKWVLNHED 490
              Y  E   F SIP LI    H  +      +    ++   +P       +KW ++  +
Sbjct: 211 GQWYVAERHAFQSIPELIWYHQHNAAGLMTRLRYPVGLMGSCLPATAGFSYEKWEIDPSE 270

Query: 491 LVLGEQIGRGNFGEVFSGRLRADNTLVAVKSCRETLPPDLKAKFLQEARILKQYSHPNIV 550
           L   ++IG G FG V  G  R+ +  VA+K+  E    +    F++EA+++ + SH  +V
Sbjct: 271 LAFIKEIGSGQFGVVHLGEWRS-HIQVAIKAINEGSMSE--EDFIEEAKVMMKLSHSKLV 327

Query: 551 RLIGVCTQKQPIYIVMELVQGGDFLTFLRTEGARLRVKTLLQMVGDAAAGMEYLESKCCI 610
           +L GVC Q++P+YIV E ++ G  L +LR    +LR + LL +  D   GMEYLE    I
Sbjct: 328 QLYGVCIQRKPLYIVTEFMENGCLLNYLRENKGKLRKEMLLSVCQDICEGMEYLERNGYI 387

Query: 611 HRDLAARNCLVTEKNVLKISDFGMSREEADGVYAASGGLRQVPVKWTAPEALNYGRYSSE 670
           HRDLAARNCLV+   ++KISDFGM+R   D  Y +S G +  P+KW+ PE   + +YSS+
Sbjct: 388 HRDLAARNCLVSSTCIVKISDFGMTRYVLDDEYVSSFGAK-FPIKWSPPEVFLFNKYSSK 446

Query: 671 SDVWSFGILLWETFSLGASPYPNLSNQQTREFVEKGGRLPCPELCPDAVFRLMEQCWAYE 730
           SDVWSFG+L+WE F+ G  P+ N SN Q  E + +G RL  P L P +++ +M  CW  +
Sbjct: 447 SDVWSFGVLMWEVFTEGKMPFENKSNLQVVEAISEGFRLYRPHLAPMSIYEVMYSCWHEK 506

Query: 731 PGQRPSFSTIYQELQSI 747
           P  RP+F+ + + +  I
Sbjct: 507 PEGRPTFAELLRAVTEI 523


>gi|19924165 proto-oncogene c-ros-1 protein precursor [Homo sapiens]
          Length = 2347

 Score =  220 bits (560), Expect = 4e-57
 Identities = 118/277 (42%), Positives = 167/277 (60%), Gaps = 17/277 (6%)

Query: 489  EDLVLGEQIGRGNFGEVFSGR------LRADNTLVAVKSCRETLPPDLKAKFLQEARILK 542
            E L L   +G G FGEV+ G       + +    VAVK+ ++      K +FL+EA ++ 
Sbjct: 1943 EKLTLRLLLGSGAFGEVYEGTAVDILGVGSGEIKVAVKTLKKGSTDQEKIEFLKEAHLMS 2002

Query: 543  QYSHPNIVRLIGVCTQKQPIYIVMELVQGGDFLTFLRTE------GARLRVKTLLQMVGD 596
            +++HPNI++ +GVC   +P YI++EL++GGD LT+LR        G  L +  L+ +  D
Sbjct: 2003 KFNHPNILKQLGVCLLNEPQYIILELMEGGDLLTYLRKARMATFYGPLLTLVDLVDLCVD 2062

Query: 597  AAAGMEYLESKCCIHRDLAARNCLVTEKN-----VLKISDFGMSREEADGVYAASGGLRQ 651
             + G  YLE    IHRDLAARNCLV+ K+     ++KI DFG++R+     Y    G   
Sbjct: 2063 ISKGCVYLERMHFIHRDLAARNCLVSVKDYTSPRIVKIGDFGLARDIYKNDYYRKRGEGL 2122

Query: 652  VPVKWTAPEALNYGRYSSESDVWSFGILLWETFSLGASPYPNLSNQQTREFVEKGGRLPC 711
            +PV+W APE+L  G ++++SDVWSFGIL+WE  +LG  PYP  SN     +V+ GGRL  
Sbjct: 2123 LPVRWMAPESLMDGIFTTQSDVWSFGILIWEILTLGHQPYPAHSNLDVLNYVQTGGRLEP 2182

Query: 712  PELCPDAVFRLMEQCWAYEPGQRPSFSTIYQELQSIR 748
            P  CPD ++ LM QCWA EP QRP+F  I  +LQ  R
Sbjct: 2183 PRNCPDDLWNLMTQCWAQEPDQRPTFHRIQDQLQLFR 2219


>gi|4557665 insulin-like growth factor 1 receptor precursor [Homo
            sapiens]
          Length = 1367

 Score =  218 bits (556), Expect = 1e-56
 Identities = 108/278 (38%), Positives = 165/278 (59%), Gaps = 14/278 (5%)

Query: 482  DKWVLNHEDLVLGEQIGRGNFGEVFSGRLRA-----DNTLVAVKSCRETLPPDLKAKFLQ 536
            D+W +  E + +  ++G+G+FG V+ G  +        T VA+K+  E      + +FL 
Sbjct: 990  DEWEVAREKITMSRELGQGSFGMVYEGVAKGVVKDEPETRVAIKTVNEAASMRERIEFLN 1049

Query: 537  EARILKQYSHPNIVRLIGVCTQKQPIYIVMELVQGGDFLTFLRTEGARLR---------V 587
            EA ++K+++  ++VRL+GV +Q QP  ++MEL+  GD  ++LR+    +          +
Sbjct: 1050 EASVMKEFNCHHVVRLLGVVSQGQPTLVIMELMTRGDLKSYLRSLRPEMENNPVLAPPSL 1109

Query: 588  KTLLQMVGDAAAGMEYLESKCCIHRDLAARNCLVTEKNVLKISDFGMSREEADGVYAASG 647
              ++QM G+ A GM YL +   +HRDLAARNC+V E   +KI DFGM+R+  +  Y   G
Sbjct: 1110 SKMIQMAGEIADGMAYLNANKFVHRDLAARNCMVAEDFTVKIGDFGMTRDIYETDYYRKG 1169

Query: 648  GLRQVPVKWTAPEALNYGRYSSESDVWSFGILLWETFSLGASPYPNLSNQQTREFVEKGG 707
            G   +PV+W +PE+L  G +++ SDVWSFG++LWE  +L   PY  LSN+Q   FV +GG
Sbjct: 1170 GKGLLPVRWMSPESLKDGVFTTYSDVWSFGVVLWEIATLAEQPYQGLSNEQVLRFVMEGG 1229

Query: 708  RLPCPELCPDAVFRLMEQCWAYEPGQRPSFSTIYQELQ 745
             L  P+ CPD +F LM  CW Y P  RPSF  I   ++
Sbjct: 1230 LLDKPDNCPDMLFELMRMCWQYNPKMRPSFLEIISSIK 1267


>gi|18250298 src-related kinase lacking C-terminal regulatory
           tyrosine and N-terminal myristylation sites [Homo
           sapiens]
          Length = 488

 Score =  217 bits (553), Expect = 3e-56
 Identities = 125/317 (39%), Positives = 185/317 (58%), Gaps = 13/317 (4%)

Query: 441 NLYRLEGEGFPSIPLLIDHLLST----QQPLTKKSGVVLHRAVPKDKWVLNHEDLVLGEQ 496
           +LY  +G  FP +  L+ +  +     Q PL +    +  +A  +D W   H +  LG +
Sbjct: 178 SLYLQKGRLFPGLEELLTYYKANWKLIQNPLLQPC--MPQKAPRQDVWERPHSEFALGRK 235

Query: 497 IGRGNFGEVFSGRLRADNTLVAVKSCRETLPPDLKAKFL-QEARILKQYSHPNIVRLIGV 555
           +G G FGEV+ G L   +  VA+K  +     ++K   L +E + LK   H  ++RL  V
Sbjct: 236 LGEGYFGEVWEG-LWLGSLPVAIKVIKSA---NMKLTDLAKEIQTLKGLRHERLIRLHAV 291

Query: 556 CTQKQPIYIVMELVQGGDFLTFLRT-EGARLRVKTLLQMVGDAAAGMEYLESKCCIHRDL 614
           C+  +P+YIV EL++ G+   FL T EG  LR+  LL      A GM YLE +  +HRDL
Sbjct: 292 CSGGEPVYIVTELMRKGNLQAFLGTPEGRALRLPPLLGFACQVAEGMSYLEEQRVVHRDL 351

Query: 615 AARNCLVTEKNVLKISDFGMSREEADGVYAASGGLRQVPVKWTAPEALNYGRYSSESDVW 674
           AARN LV +    K++DFG++R   D +Y+ S   + +PVKWTAPEA NY  +S +SDVW
Sbjct: 352 AARNVLVDDGLACKVADFGLARLLKDDIYSPSSSSK-IPVKWTAPEAANYRVFSQKSDVW 410

Query: 675 SFGILLWETFSLGASPYPNLSNQQTREFVEKGGRLPCPELCPDAVFRLMEQCWAYEPGQR 734
           SFG+LL E F+ G  PY  ++N +T + + +G RLP P  CP  V+ LM +CW   P +R
Sbjct: 411 SFGVLLHEVFTYGQCPYEGMTNHETLQQIMRGYRLPRPAACPAEVYVLMLECWRSSPEER 470

Query: 735 PSFSTIYQELQSIRKRH 751
           PSF+T+ ++L +I + H
Sbjct: 471 PSFATLREKLHAIHRCH 487


>gi|221316650 ephrin receptor EphA1 [Homo sapiens]
          Length = 976

 Score =  215 bits (548), Expect = 1e-55
 Identities = 110/262 (41%), Positives = 163/262 (62%), Gaps = 7/262 (2%)

Query: 491 LVLGEQIGRGNFGEVFSGRLRA---DNTLVAVKSCRETLPPDLKAKFLQEARILKQYSHP 547
           L++   IG G FGEV+ G LR    D   VA+K+ ++T P      FL+EA I+ Q+SHP
Sbjct: 624 LMVDTVIGEGEFGEVYRGTLRLPSQDCKTVAIKTLKDTSPGGQWWNFLREATIMGQFSHP 683

Query: 548 NIVRLIGVCTQKQPIYIVMELVQGGDFLTFLRTEGARLRVKTLLQMVGDAAAGMEYLESK 607
           +I+ L GV T+++PI I+ E ++ G    FLR    +L    L+ M+   A+GM YL + 
Sbjct: 684 HILHLEGVVTKRKPIMIITEFMENGALDAFLREREDQLVPGQLVAMLQGIASGMNYLSNH 743

Query: 608 CCIHRDLAARNCLVTEKNVLKISDFGMSR--EEADGVYAASGGLRQVPVKWTAPEALNYG 665
             +HRDLAARN LV +    K+SDFG++R  ++ DG Y   GG  ++P++WTAPEA+ + 
Sbjct: 744 NYVHRDLAARNILVNQNLCCKVSDFGLTRLLDDFDGTYETQGG--KIPIRWTAPEAIAHR 801

Query: 666 RYSSESDVWSFGILLWETFSLGASPYPNLSNQQTREFVEKGGRLPCPELCPDAVFRLMEQ 725
            +++ SDVWSFGI++WE  S G  PY  +SNQ+  + +E G RLP P  CP  ++ LM+ 
Sbjct: 802 IFTTASDVWSFGIVMWEVLSFGDKPYGEMSNQEVMKSIEDGYRLPPPVDCPAPLYELMKN 861

Query: 726 CWAYEPGQRPSFSTIYQELQSI 747
           CWAY+  +RP F  +   L+ +
Sbjct: 862 CWAYDRARRPHFQKLQAHLEQL 883


>gi|4557377 Bruton agammaglobulinemia tyrosine kinase [Homo sapiens]
          Length = 659

 Score =  214 bits (546), Expect = 2e-55
 Identities = 106/265 (40%), Positives = 166/265 (62%), Gaps = 6/265 (2%)

Query: 484 WVLNHEDLVLGEQIGRGNFGEVFSGRLRADNTLVAVKSCRE-TLPPDLKAKFLQEARILK 542
           W ++ +DL   +++G G FG V  G+ R     VA+K  +E ++  D   +F++EA+++ 
Sbjct: 395 WEIDPKDLTFLKELGTGQFGVVKYGKWRGQYD-VAIKMIKEGSMSED---EFIEEAKVMM 450

Query: 543 QYSHPNIVRLIGVCTQKQPIYIVMELVQGGDFLTFLRTEGARLRVKTLLQMVGDAAAGME 602
             SH  +V+L GVCT+++PI+I+ E +  G  L +LR    R + + LL+M  D    ME
Sbjct: 451 NLSHEKLVQLYGVCTKQRPIFIITEYMANGCLLNYLREMRHRFQTQQLLEMCKDVCEAME 510

Query: 603 YLESKCCIHRDLAARNCLVTEKNVLKISDFGMSREEADGVYAASGGLRQVPVKWTAPEAL 662
           YLESK  +HRDLAARNCLV ++ V+K+SDFG+SR   D  Y +S G  + PV+W+ PE L
Sbjct: 511 YLESKQFLHRDLAARNCLVNDQGVVKVSDFGLSRYVLDDEYTSSVG-SKFPVRWSPPEVL 569

Query: 663 NYGRYSSESDVWSFGILLWETFSLGASPYPNLSNQQTREFVEKGGRLPCPELCPDAVFRL 722
            Y ++SS+SD+W+FG+L+WE +SLG  PY   +N +T E + +G RL  P L  + V+ +
Sbjct: 570 MYSKFSSKSDIWAFGVLMWEIYSLGKMPYERFTNSETAEHIAQGLRLYRPHLASEKVYTI 629

Query: 723 MEQCWAYEPGQRPSFSTIYQELQSI 747
           M  CW  +  +RP+F  +   +  +
Sbjct: 630 MYSCWHEKADERPTFKILLSNILDV 654


>gi|4503823 protein-tyrosine kinase fyn isoform a [Homo sapiens]
          Length = 537

 Score =  213 bits (543), Expect = 4e-55
 Identities = 122/307 (39%), Positives = 178/307 (57%), Gaps = 17/307 (5%)

Query: 450 FPSIPLLIDHLLSTQQPLTKKSGVVLHRAVP---------KDKWVLNHEDLVLGEQIGRG 500
           F ++  L+ H       L  +  V  H+ +P         KD W +  E L L +++G G
Sbjct: 221 FETLQQLVQHYSERAAGLCCRLVVPCHKGMPRLTDLSVKTKDVWEIPRESLQLIKRLGNG 280

Query: 501 NFGEVFSGRLRADNTLVAVKSCRE-TLPPDLKAKFLQEARILKQYSHPNIVRLIGVCTQK 559
            FGEV+ G     NT VA+K+ +  T+ P+    FL+EA+I+K+  H  +V+L  V ++ 
Sbjct: 281 QFGEVWMGTWNG-NTKVAIKTLKPGTMSPE---SFLEEAQIMKKLKHDKLVQLYAVVSE- 335

Query: 560 QPIYIVMELVQGGDFLTFLRT-EGARLRVKTLLQMVGDAAAGMEYLESKCCIHRDLAARN 618
           +PIYIV E +  G  L FL+  EG  L++  L+ M    AAGM Y+E    IHRDL + N
Sbjct: 336 EPIYIVTEYMNKGSLLDFLKDGEGRALKLPNLVDMAAQVAAGMAYIERMNYIHRDLRSAN 395

Query: 619 CLVTEKNVLKISDFGMSREEADGVYAASGGLRQVPVKWTAPEALNYGRYSSESDVWSFGI 678
            LV    + KI+DFG++R   D  Y A  G +  P+KWTAPEA  YGR++ +SDVWSFGI
Sbjct: 396 ILVGNGLICKIADFGLARLIEDNEYTARQGAK-FPIKWTAPEAALYGRFTIKSDVWSFGI 454

Query: 679 LLWETFSLGASPYPNLSNQQTREFVEKGGRLPCPELCPDAVFRLMEQCWAYEPGQRPSFS 738
           LL E  + G  PYP ++N++  E VE+G R+PCP+ CP ++  LM  CW  +P +RP+F 
Sbjct: 455 LLTELVTKGRVPYPGMNNREVLEQVERGYRMPCPQDCPISLHELMIHCWKKDPEERPTFE 514

Query: 739 TIYQELQ 745
            +   L+
Sbjct: 515 YLQSFLE 521


>gi|38202217 proto-oncogene tyrosine-protein kinase SRC [Homo
           sapiens]
          Length = 536

 Score =  211 bits (536), Expect = 3e-54
 Identities = 121/289 (41%), Positives = 174/289 (60%), Gaps = 12/289 (4%)

Query: 459 HLLSTQQPLTKKSGVVLHRAVPKDKWVLNHEDLVLGEQIGRGNFGEVFSGRLRADNTLVA 518
           H L+T  P +K       + + KD W +  E L L  ++G+G FGEV+ G      T VA
Sbjct: 242 HRLTTVCPTSKPQT----QGLAKDAWEIPRESLRLEVKLGQGCFGEVWMGTWNG-TTRVA 296

Query: 519 VKSCRE-TLPPDLKAKFLQEARILKQYSHPNIVRLIGVCTQKQPIYIVMELVQGGDFLTF 577
           +K+ +  T+ P+    FLQEA+++K+  H  +V+L  V ++ +PIYIV E +  G  L F
Sbjct: 297 IKTLKPGTMSPEA---FLQEAQVMKKLRHEKLVQLYAVVSE-EPIYIVTEYMSKGSLLDF 352

Query: 578 LRTE-GARLRVKTLLQMVGDAAAGMEYLESKCCIHRDLAARNCLVTEKNVLKISDFGMSR 636
           L+ E G  LR+  L+ M    A+GM Y+E    +HRDL A N LV E  V K++DFG++R
Sbjct: 353 LKGETGKYLRLPQLVDMAAQIASGMAYVERMNYVHRDLRAANILVGENLVCKVADFGLAR 412

Query: 637 EEADGVYAASGGLRQVPVKWTAPEALNYGRYSSESDVWSFGILLWETFSLGASPYPNLSN 696
              D  Y A  G +  P+KWTAPEA  YGR++ +SDVWSFGILL E  + G  PYP + N
Sbjct: 413 LIEDNEYTARQGAK-FPIKWTAPEAALYGRFTIKSDVWSFGILLTELTTKGRVPYPGMVN 471

Query: 697 QQTREFVEKGGRLPCPELCPDAVFRLMEQCWAYEPGQRPSFSTIYQELQ 745
           ++  + VE+G R+PCP  CP+++  LM QCW  EP +RP+F  +   L+
Sbjct: 472 REVLDQVERGYRMPCPPECPESLHDLMCQCWRKEPEERPTFEYLQAFLE 520


>gi|4885609 proto-oncogene tyrosine-protein kinase SRC [Homo
           sapiens]
          Length = 536

 Score =  211 bits (536), Expect = 3e-54
 Identities = 121/289 (41%), Positives = 174/289 (60%), Gaps = 12/289 (4%)

Query: 459 HLLSTQQPLTKKSGVVLHRAVPKDKWVLNHEDLVLGEQIGRGNFGEVFSGRLRADNTLVA 518
           H L+T  P +K       + + KD W +  E L L  ++G+G FGEV+ G      T VA
Sbjct: 242 HRLTTVCPTSKPQT----QGLAKDAWEIPRESLRLEVKLGQGCFGEVWMGTWNG-TTRVA 296

Query: 519 VKSCRE-TLPPDLKAKFLQEARILKQYSHPNIVRLIGVCTQKQPIYIVMELVQGGDFLTF 577
           +K+ +  T+ P+    FLQEA+++K+  H  +V+L  V ++ +PIYIV E +  G  L F
Sbjct: 297 IKTLKPGTMSPEA---FLQEAQVMKKLRHEKLVQLYAVVSE-EPIYIVTEYMSKGSLLDF 352

Query: 578 LRTE-GARLRVKTLLQMVGDAAAGMEYLESKCCIHRDLAARNCLVTEKNVLKISDFGMSR 636
           L+ E G  LR+  L+ M    A+GM Y+E    +HRDL A N LV E  V K++DFG++R
Sbjct: 353 LKGETGKYLRLPQLVDMAAQIASGMAYVERMNYVHRDLRAANILVGENLVCKVADFGLAR 412

Query: 637 EEADGVYAASGGLRQVPVKWTAPEALNYGRYSSESDVWSFGILLWETFSLGASPYPNLSN 696
              D  Y A  G +  P+KWTAPEA  YGR++ +SDVWSFGILL E  + G  PYP + N
Sbjct: 413 LIEDNEYTARQGAK-FPIKWTAPEAALYGRFTIKSDVWSFGILLTELTTKGRVPYPGMVN 471

Query: 697 QQTREFVEKGGRLPCPELCPDAVFRLMEQCWAYEPGQRPSFSTIYQELQ 745
           ++  + VE+G R+PCP  CP+++  LM QCW  EP +RP+F  +   L+
Sbjct: 472 REVLDQVERGYRMPCPPECPESLHDLMCQCWRKEPEERPTFEYLQAFLE 520


>gi|42544153 leukocyte receptor tyrosine kinase isoform 1 precursor
           [Homo sapiens]
          Length = 864

 Score =  211 bits (536), Expect = 3e-54
 Identities = 116/270 (42%), Positives = 161/270 (59%), Gaps = 14/270 (5%)

Query: 490 DLVLGEQIGRGNFGEVFSGR---LRADNT--LVAVKSCRETLPPDLKAKFLQEARILKQY 544
           ++ L   +G G FGEV+ G    L  D++   VA+K+  E   P  +  FL EA I+ ++
Sbjct: 509 NVTLLRALGHGAFGEVYEGLVIGLPGDSSPLQVAIKTLPELCSPQDELDFLMEALIISKF 568

Query: 545 SHPNIVRLIGVCTQKQPIYIVMELVQGGDFLTFLRT------EGARLRVKTLLQMVGDAA 598
            H NIVR +G+  +  P  I++EL+ GGD  +FLR       + + L ++ LLQ+  D A
Sbjct: 569 RHQNIVRCVGLSLRATPRLILLELMSGGDMKSFLRHSRPHLGQPSPLVMRDLLQLAQDIA 628

Query: 599 AGMEYLESKCCIHRDLAARNCLVT---EKNVLKISDFGMSREEADGVYAASGGLRQVPVK 655
            G  YLE    IHRD+AARNCL++      V KI DFGM+R+     Y   G    +PVK
Sbjct: 629 QGCHYLEENHFIHRDIAARNCLLSCAGPSRVAKIGDFGMARDIYRASYYRRGDRALLPVK 688

Query: 656 WTAPEALNYGRYSSESDVWSFGILLWETFSLGASPYPNLSNQQTREFVEKGGRLPCPELC 715
           W  PEA   G ++S++D WSFG+LLWE FSLG  PYP  +NQ+  +FV  GGR+  P  C
Sbjct: 689 WMPPEAFLEGIFTSKTDSWSFGVLLWEIFSLGYMPYPGRTNQEVLDFVVGGGRMDPPRGC 748

Query: 716 PDAVFRLMEQCWAYEPGQRPSFSTIYQELQ 745
           P  V+R+M QCW +EP  RPSF++I + LQ
Sbjct: 749 PGPVYRIMTQCWQHEPELRPSFASILERLQ 778


  Database: hs.faa
    Posted date:  Aug 4, 2009  4:42 PM
  Number of letters in database: 18,247,518
  Number of sequences in database:  37,866
  
Lambda     K      H
   0.317    0.133    0.385 

Gapped
Lambda     K      H
   0.267   0.0410    0.140 


Matrix: BLOSUM62
Gap Penalties: Existence: 11, Extension: 1
Number of Hits to DB: 29,425,416
Number of Sequences: 37866
Number of extensions: 1349265
Number of successful extensions: 9140
Number of sequences better than 10.0: 30
Number of HSP's better than 10.0 without gapping: 606
Number of HSP's successfully gapped in prelim test: 486
Number of HSP's that attempted gapping in prelim test: 5913
Number of HSP's gapped (non-prelim): 2059
length of query: 752
length of database: 18,247,518
effective HSP length: 110
effective length of query: 642
effective length of database: 14,082,258
effective search space: 9040809636
effective search space used: 9040809636
T: 11
A: 40
X1: 16 ( 7.3 bits)
X2: 38 (14.6 bits)
X3: 64 (24.7 bits)
S1: 41 (21.7 bits)
S2: 66 (30.0 bits)

Search results were obtained with NCBI BLAST and RefSeq entries.


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Guide to the Human Genome
Copyright © 2010 by Stewart Scherer. All rights reserved.

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