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Search of human proteins with 21956639
BLASTP 2.2.11 [Jun-05-2005]
Reference: Altschul, Stephen F., Thomas L. Madden, Alejandro A. Schaffer,
Jinghui Zhang, Zheng Zhang, Webb Miller, and David J. Lipman (1997),
"Gapped BLAST and PSI-BLAST: a new generation of protein database search
programs", Nucleic Acids Res. 25:3389-3402.
Query= gi|21956639 ankyrin repeat and BTB (POZ) domain containing 2
[Homo sapiens]
(839 letters)
Database: hs.faa
37,866 sequences; 18,247,518 total letters
Searching..................................................done
Score E
Sequences producing significant alignments: (bits) Value
gi|21956639 ankyrin repeat and BTB (POZ) domain containing 2 [Ho... 1679 0.0
gi|65786661 BTB (POZ) domain containing 11 isoform a [Homo sapiens] 974 0.0
gi|62953116 BTB (POZ) domain containing 11 isoform b [Homo sapiens] 770 0.0
gi|57242759 regulator of chromosome condensation (RCC1) and BTB ... 76 1e-13
gi|4557445 regulator of chromosome condensation and BTB domain c... 76 1e-13
gi|38683807 ankyrin repeat domain protein 17 isoform a [Homo sap... 72 2e-12
gi|38683816 ankyrin repeat domain protein 17 isoform b [Homo sap... 72 2e-12
gi|11056006 kelch-like 12 [Homo sapiens] 70 1e-11
gi|67906195 ankyrin repeat and sterile alpha motif domain contai... 69 2e-11
gi|56117834 speckle-type POZ protein [Homo sapiens] 67 7e-11
gi|56117832 speckle-type POZ protein [Homo sapiens] 67 7e-11
gi|56117830 speckle-type POZ protein [Homo sapiens] 67 7e-11
gi|56117828 speckle-type POZ protein [Homo sapiens] 67 7e-11
gi|4507183 speckle-type POZ protein [Homo sapiens] 67 7e-11
gi|56117836 speckle-type POZ protein [Homo sapiens] 67 7e-11
gi|46519147 ankyrin repeat and KH domain containing 1 isoform 1 ... 66 2e-10
gi|37620163 ANKHD1-EIF4EBP3 protein [Homo sapiens] 66 2e-10
gi|48717263 speckle-type POZ protein-like [Homo sapiens] 65 3e-10
gi|46519154 ankyrin repeat and KH domain containing 1 isoform 3 ... 64 6e-10
gi|46519151 ankyrin repeat and KH domain containing 1 isoform 2 ... 64 6e-10
gi|62988328 ankyrin repeat domain 50 [Homo sapiens] 63 1e-09
gi|157739945 tetratricopeptide repeat, ankyrin repeat and coiled... 63 1e-09
gi|209571547 kelch repeat and BTB (POZ) domain containing 4 isof... 62 2e-09
gi|209693446 kelch repeat and BTB (POZ) domain containing 4 isof... 62 2e-09
gi|151108413 BTB (POZ) domain containing 9 isoform a [Homo sapiens] 62 2e-09
gi|151108411 BTB (POZ) domain containing 9 isoform a [Homo sapiens] 62 2e-09
gi|40018614 DRE1 protein [Homo sapiens] 62 2e-09
gi|170784844 kelch-like 7 isoform 2 [Homo sapiens] 61 4e-09
gi|40255071 kelch-like 23 [Homo sapiens] 61 4e-09
gi|170784846 kelch-like 7 isoform 1 [Homo sapiens] 60 1e-08
>gi|21956639 ankyrin repeat and BTB (POZ) domain containing 2 [Homo
sapiens]
Length = 839
Score = 1679 bits (4347), Expect = 0.0
Identities = 839/839 (100%), Positives = 839/839 (100%)
Query: 1 MSAGDGLRRGKSARCGLTFSVGRFFRWMVDTRISVRIHEYAAISLTACMENLVEEIRARV 60
MSAGDGLRRGKSARCGLTFSVGRFFRWMVDTRISVRIHEYAAISLTACMENLVEEIRARV
Sbjct: 1 MSAGDGLRRGKSARCGLTFSVGRFFRWMVDTRISVRIHEYAAISLTACMENLVEEIRARV 60
Query: 61 MASHSPDGGGAGGGEVSAEALEMVINNDAELWGVLQPYEHLICGKNANGVLSLPAYFSPY 120
MASHSPDGGGAGGGEVSAEALEMVINNDAELWGVLQPYEHLICGKNANGVLSLPAYFSPY
Sbjct: 61 MASHSPDGGGAGGGEVSAEALEMVINNDAELWGVLQPYEHLICGKNANGVLSLPAYFSPY 120
Query: 121 NGGSLGHDERADAYAQLELRTLEQSLLATCVGSISELSDLVSRAMHHMQGRHPLCPGASP 180
NGGSLGHDERADAYAQLELRTLEQSLLATCVGSISELSDLVSRAMHHMQGRHPLCPGASP
Sbjct: 121 NGGSLGHDERADAYAQLELRTLEQSLLATCVGSISELSDLVSRAMHHMQGRHPLCPGASP 180
Query: 181 ARQARQPPQPITWSPDALHTLYYFLRCPQMESMENPNLDPPRMTLNNERPFMLLPPLMEW 240
ARQARQPPQPITWSPDALHTLYYFLRCPQMESMENPNLDPPRMTLNNERPFMLLPPLMEW
Sbjct: 181 ARQARQPPQPITWSPDALHTLYYFLRCPQMESMENPNLDPPRMTLNNERPFMLLPPLMEW 240
Query: 241 MRVAITYAEHRRSLTVDSGDIRQAARLLLPGLDCEPRQLKPEHCFSSFRRLDARAATEKF 300
MRVAITYAEHRRSLTVDSGDIRQAARLLLPGLDCEPRQLKPEHCFSSFRRLDARAATEKF
Sbjct: 241 MRVAITYAEHRRSLTVDSGDIRQAARLLLPGLDCEPRQLKPEHCFSSFRRLDARAATEKF 300
Query: 301 NQDLGFRMLNCGRTDLINQAIEALGPDGVNTMDDQGMTPLMYACAAGDEAMVQMLIDAGA 360
NQDLGFRMLNCGRTDLINQAIEALGPDGVNTMDDQGMTPLMYACAAGDEAMVQMLIDAGA
Sbjct: 301 NQDLGFRMLNCGRTDLINQAIEALGPDGVNTMDDQGMTPLMYACAAGDEAMVQMLIDAGA 360
Query: 361 NLDIQVPSNSPRHPSIHPDSRHWTSLTFAVLHGHISVVQLLLDAGAHVEGSAVNGGEDSY 420
NLDIQVPSNSPRHPSIHPDSRHWTSLTFAVLHGHISVVQLLLDAGAHVEGSAVNGGEDSY
Sbjct: 361 NLDIQVPSNSPRHPSIHPDSRHWTSLTFAVLHGHISVVQLLLDAGAHVEGSAVNGGEDSY 420
Query: 421 AETPLQLASAAGNYELVSLLLSRGADPLLSMLEAHGMGSSLHEDMNCFSHSAAHGHRNVL 480
AETPLQLASAAGNYELVSLLLSRGADPLLSMLEAHGMGSSLHEDMNCFSHSAAHGHRNVL
Sbjct: 421 AETPLQLASAAGNYELVSLLLSRGADPLLSMLEAHGMGSSLHEDMNCFSHSAAHGHRNVL 480
Query: 481 RKLLTQPQQAKADVLSLEEILAEGVEESDASSQGSGSEGPVRLSRTRTKALQEAMYYSAE 540
RKLLTQPQQAKADVLSLEEILAEGVEESDASSQGSGSEGPVRLSRTRTKALQEAMYYSAE
Sbjct: 481 RKLLTQPQQAKADVLSLEEILAEGVEESDASSQGSGSEGPVRLSRTRTKALQEAMYYSAE 540
Query: 541 HGYVDITMELRALGVPWKLHIWIESLRTSFSQSRYSVVQSLLRDFSSIREEEYNEELVTE 600
HGYVDITMELRALGVPWKLHIWIESLRTSFSQSRYSVVQSLLRDFSSIREEEYNEELVTE
Sbjct: 541 HGYVDITMELRALGVPWKLHIWIESLRTSFSQSRYSVVQSLLRDFSSIREEEYNEELVTE 600
Query: 601 GLQLMFDILKTSKNDSVIQQLATIFTHCYGSSPIPSIPEIRKTLPARLDPHFLNNKEMSD 660
GLQLMFDILKTSKNDSVIQQLATIFTHCYGSSPIPSIPEIRKTLPARLDPHFLNNKEMSD
Sbjct: 601 GLQLMFDILKTSKNDSVIQQLATIFTHCYGSSPIPSIPEIRKTLPARLDPHFLNNKEMSD 660
Query: 661 VTFLVEGKLFYAHKVLLVTASNRFKTLMTNKSEQDGDSSKTIEISDMKYHIFQMMMQYLY 720
VTFLVEGKLFYAHKVLLVTASNRFKTLMTNKSEQDGDSSKTIEISDMKYHIFQMMMQYLY
Sbjct: 661 VTFLVEGKLFYAHKVLLVTASNRFKTLMTNKSEQDGDSSKTIEISDMKYHIFQMMMQYLY 720
Query: 721 YGGTESMEIPTTDILELLSAASLFQLDALQRHCEILCSQTLSMESAVNTYKYAKIHNAPE 780
YGGTESMEIPTTDILELLSAASLFQLDALQRHCEILCSQTLSMESAVNTYKYAKIHNAPE
Sbjct: 721 YGGTESMEIPTTDILELLSAASLFQLDALQRHCEILCSQTLSMESAVNTYKYAKIHNAPE 780
Query: 781 LALFCEGFFLKHMKALLEQDAFRQLIYGRSSKVQGLDPLQDLQNTLAERVHSVYITSRV 839
LALFCEGFFLKHMKALLEQDAFRQLIYGRSSKVQGLDPLQDLQNTLAERVHSVYITSRV
Sbjct: 781 LALFCEGFFLKHMKALLEQDAFRQLIYGRSSKVQGLDPLQDLQNTLAERVHSVYITSRV 839
>gi|65786661 BTB (POZ) domain containing 11 isoform a [Homo sapiens]
Length = 1104
Score = 974 bits (2518), Expect = 0.0
Identities = 499/915 (54%), Positives = 648/915 (70%), Gaps = 89/915 (9%)
Query: 2 SAGDGLRRGKSARCGLTFSVGRFFRWMVDTRISVRIHEYAAISLTACMENLVEEIRARVM 61
+ GD L RGKSARCGLTFSVGR +RWMVD+R+++RIHE+AAI LTACME+L +I +RV+
Sbjct: 194 AGGDRLGRGKSARCGLTFSVGRVYRWMVDSRVALRIHEHAAIYLTACMESLFRDIYSRVV 253
Query: 62 AS---------------------------------HSPDGGGAGGGEVSA---------- 78
AS +P GG A GG SA
Sbjct: 254 ASGVPRSCSGPGSGSGSGPGPSSGPGAAPAADKEREAPGGGAASGGACSAASSASGGSSC 313
Query: 79 -----------------------------------EALEMVINNDAELWGVLQPYEHLIC 103
E LE +NND+E+WG+LQPY+HLIC
Sbjct: 314 CAPPAAAAAAVPPAAAANHHHHHHHALHEAPKFTVETLEHTVNNDSEIWGLLQPYQHLIC 373
Query: 104 GKNANGVLSLPAYFSPYNGGSLGHDE-RADAYAQLELRTLEQSLLATCVGSISELSDLVS 162
GKNA+GVL LP + + + ++Q ELRT+EQSLLAT VGSI+ELSDLVS
Sbjct: 374 GKNASGVLCLPDSLNLHRDPQRSNKPGELPMFSQSELRTIEQSLLATRVGSIAELSDLVS 433
Query: 163 RAMHHMQGRHPLCPGASPARQARQPPQPITWSPDALHTLYYFLRCPQMESMENPNLDPPR 222
RAMHH+Q + G +Q + W P+AL+TL YF+ CPQME ENPN++P +
Sbjct: 434 RAMHHLQPLNAKHHGNGTPLHHKQGA--LYWEPEALYTLCYFMHCPQME-WENPNVEPSK 490
Query: 223 MTLNNERPFMLLPPLMEWMRVAITYAEHRRSLTVDSGDIRQAARLLLPGLDCEPRQLKPE 282
+ L ERPF++LPPLMEW+RVA+ +A HRRS ++DS D+RQAARLLLPG+DCEPRQL+ +
Sbjct: 491 VNLQVERPFLVLPPLMEWIRVAVAHAGHRRSFSMDSDDVRQAARLLLPGVDCEPRQLRAD 550
Query: 283 HCFSSFRRLDARAATEKFNQDLGFRMLNCGRTDLINQAIEALGPDGVNTMDDQGMTPLMY 342
CF + R+LDA A KF QDLGFRMLNCGRTDL+ QA+ LGPDG+NTM +QGMTPLMY
Sbjct: 551 DCFCASRKLDAVAIEAKFKQDLGFRMLNCGRTDLVKQAVSLLGPDGINTMSEQGMTPLMY 610
Query: 343 ACAAGDEAMVQMLIDAGANLDIQVPSNSPRHPSIHPDSRHWTSLTFAVLHGHISVVQLLL 402
AC GDEAMVQML+DAGA+L+++V S ++PS+HP++RHWT+LTFAVLHGHI VVQLLL
Sbjct: 611 ACVRGDEAMVQMLLDAGADLNVEVVSTPHKYPSVHPETRHWTALTFAVLHGHIPVVQLLL 670
Query: 403 DAGAHVEGSAVNGGEDSYAETPLQLASAAGNYELVSLLLSRGADPLLSMLEAHGMGSSLH 462
DAGA VEGS V GE++Y+ETPLQLA+A GN+ELVSLLL RGADPL+ + +G+ ++
Sbjct: 671 DAGAKVEGS-VEHGEENYSETPLQLAAAVGNFELVSLLLERGADPLIGTMYRNGISTTPQ 729
Query: 463 EDMNCFSHSAAHGHRNVLRKLLTQPQQAKADVLSLEEILAEGVEESDASSQGSGSEGPVR 522
DMN FS +AAHGHRNV RKLL QP++ K+D+LSLEEILAEG + ++ + + R
Sbjct: 730 GDMNSFSQAAAHGHRNVFRKLLAQPEKEKSDILSLEEILAEGTDLAETAPPPLCAS---R 786
Query: 523 LSRTRTKALQEAMYYSAEHGYVDITMELRALGVPWKLHIWIESLRTSFSQSRYSVVQSLL 582
S+ + +AL+EAMY+SAEHGYVD+T+++R++GVPW LH W+ESLR +F Q R ++Q LL
Sbjct: 787 NSKAKLRALREAMYHSAEHGYVDVTIDIRSIGVPWTLHTWLESLRIAFQQHRRPLIQCLL 846
Query: 583 RDFSSIREEEYNEELVTEGLQLMFDILKTSKNDSVIQQLATIFTHCYGSSPIPSIPEIRK 642
++F +I+EEEY EELVT+GL LMF+ILK SKN+ + QQL IFTHCYG PIP + EI++
Sbjct: 847 KEFKTIQEEEYTEELVTQGLPLMFEILKASKNEVISQQLCVIFTHCYGPYPIPKLTEIKR 906
Query: 643 TLPARLDPHFLNNKEMSDVTFLVEGKLFYAHKVLLVTASNRFKTLMTNKSEQDGDSSKTI 702
+RLDPHFLNNKEMSDVTFLVEG+ FYAHKVLL TAS RFK L+++K DG I
Sbjct: 907 KQTSRLDPHFLNNKEMSDVTFLVEGRPFYAHKVLLFTASPRFKALLSSKPTNDG---TCI 963
Query: 703 EISDMKYHIFQMMMQYLYYGGTESMEIPTTDILELLSAASLFQLDALQRHCEILCSQTLS 762
EI +KY IFQ++MQYLYYGG ES+ I +I+ELLSAA FQL+ALQRHCEI+C+++++
Sbjct: 964 EIGYVKYSIFQLVMQYLYYGGPESLLIKNNEIMELLSAAKFFQLEALQRHCEIICAKSIN 1023
Query: 763 MESAVNTYKYAKIHNAPELALFCEGFFLKHMKALLEQDAFRQLIYGRSSKVQGLDPLQDL 822
++ V+ Y +AK EL+ +CEG+FLK+M L+E +AF+QL+Y ++ + G D LQDL
Sbjct: 1024 TDNCVDIYNHAKFLGVTELSAYCEGYFLKNMMVLIENEAFKQLLYDKNGEGTGQDVLQDL 1083
Query: 823 QNTLAERVHSVYITS 837
Q TLA R+ S++++S
Sbjct: 1084 QRTLAIRIQSIHLSS 1098
>gi|62953116 BTB (POZ) domain containing 11 isoform b [Homo sapiens]
Length = 641
Score = 770 bits (1988), Expect = 0.0
Identities = 371/610 (60%), Positives = 485/610 (79%), Gaps = 7/610 (1%)
Query: 228 ERPFMLLPPLMEWMRVAITYAEHRRSLTVDSGDIRQAARLLLPGLDCEPRQLKPEHCFSS 287
+RPF++LPPLMEW+RVA+ +A HRRS ++DS D+RQAARLLLPG+DCEPRQL+ + CF +
Sbjct: 33 QRPFLVLPPLMEWIRVAVAHAGHRRSFSMDSDDVRQAARLLLPGVDCEPRQLRADDCFCA 92
Query: 288 FRRLDARAATEKFNQDLGFRMLNCGRTDLINQAIEALGPDGVNTMDDQGMTPLMYACAAG 347
R+LDA A KF QDLGFRMLNCGRTDL+ QA+ LGPDG+NTM +QGMTPLMYAC G
Sbjct: 93 SRKLDAVAIEAKFKQDLGFRMLNCGRTDLVKQAVSLLGPDGINTMSEQGMTPLMYACVRG 152
Query: 348 DEAMVQMLIDAGANLDIQVPSNSPRHPSIHPDSRHWTSLTFAVLHGHISVVQLLLDAGAH 407
DEAMVQML+DAGA+L+++V S ++PS+HP++RHWT+LTFAVLHGHI VVQLLLDAGA
Sbjct: 153 DEAMVQMLLDAGADLNVEVVSTPHKYPSVHPETRHWTALTFAVLHGHIPVVQLLLDAGAK 212
Query: 408 VEGSAVNGGEDSYAETPLQLASAAGNYELVSLLLSRGADPLLSMLEAHGMGSSLHEDMNC 467
VEGS V GE++Y+ETPLQLA+A GN+ELVSLLL RGADPL+ + +G+ ++ DMN
Sbjct: 213 VEGS-VEHGEENYSETPLQLAAAVGNFELVSLLLERGADPLIGTMYRNGISTTPQGDMNS 271
Query: 468 FSHSAAHGHRNVLRKLLTQPQQAKADVLSLEEILAEGVEESDASSQGSGSEGPVRLSRTR 527
FS +AAHGHRNV RKLL QP++ K+D+LSLEEILAEG + ++ + + R S+ +
Sbjct: 272 FSQAAAHGHRNVFRKLLAQPEKEKSDILSLEEILAEGTDLAETAPPPLCAS---RNSKAK 328
Query: 528 TKALQEAMYYSAEHGYVDITMELRALGVPWKLHIWIESLRTSFSQSRYSVVQSLLRDFSS 587
+AL+EAMY+SAEHGYVD+T+++R++GVPW LH W+ESLR +F Q R ++Q LL++F +
Sbjct: 329 LRALREAMYHSAEHGYVDVTIDIRSIGVPWTLHTWLESLRIAFQQHRRPLIQCLLKEFKT 388
Query: 588 IREEEYNEELVTEGLQLMFDILKTSKNDSVIQQLATIFTHCYGSSPIPSIPEIRKTLPAR 647
I+EEEY EELVT+GL LMF+ILK SKN+ + QQL IFTHCYG PIP + EI++ +R
Sbjct: 389 IQEEEYTEELVTQGLPLMFEILKASKNEVISQQLCVIFTHCYGPYPIPKLTEIKRKQTSR 448
Query: 648 LDPHFLNNKEMSDVTFLVEGKLFYAHKVLLVTASNRFKTLMTNKSEQDGDSSKTIEISDM 707
LDPHFLNNKEMSDVTFLVEG+ FYAHKVLL TAS RFK L+++K DG IEI +
Sbjct: 449 LDPHFLNNKEMSDVTFLVEGRPFYAHKVLLFTASPRFKALLSSKPTNDG---TCIEIGYV 505
Query: 708 KYHIFQMMMQYLYYGGTESMEIPTTDILELLSAASLFQLDALQRHCEILCSQTLSMESAV 767
KY IFQ++MQYLYYGG ES+ I +I+ELLSAA FQL+ALQRHCEI+C+++++ ++ V
Sbjct: 506 KYSIFQLVMQYLYYGGPESLLIKNNEIMELLSAAKFFQLEALQRHCEIICAKSINTDNCV 565
Query: 768 NTYKYAKIHNAPELALFCEGFFLKHMKALLEQDAFRQLIYGRSSKVQGLDPLQDLQNTLA 827
+ Y +AK EL+ +CEG+FLK+M L+E +AF+QL+Y ++ + G D LQDLQ TLA
Sbjct: 566 DIYNHAKFLGVTELSAYCEGYFLKNMMVLIENEAFKQLLYDKNGEGTGQDVLQDLQRTLA 625
Query: 828 ERVHSVYITS 837
R+ S++++S
Sbjct: 626 IRIQSIHLSS 635
>gi|57242759 regulator of chromosome condensation (RCC1) and BTB
(POZ) domain containing protein 1 [Homo sapiens]
Length = 531
Score = 75.9 bits (185), Expect = 1e-13
Identities = 39/152 (25%), Positives = 85/152 (55%), Gaps = 5/152 (3%)
Query: 654 NNKEMSDVTFLVEGKLFYAHKVLLVTASNRFKTLMTNKSEQDGDSSKTIEISDMKYHIFQ 713
++ E +D+ F ++GK + HK +L F+++ +S + D + IEI Y +++
Sbjct: 365 DSPETADLKFRIDGKYIHVHKAVLKIRCEHFRSMF--QSYWNEDMKEVIEIDQFSYPVYR 422
Query: 714 MMMQYLYYGGTESMEIPTTDILELLSAASLFQLDALQRHCEILCSQTLSMESAVNTYKYA 773
+QYLY T+++++P D + LL A+ + + L++ C+ + + +++E+A + + A
Sbjct: 423 AFLQYLY---TDTVDLPPEDAIGLLDLATSYCENRLKKLCQHIIKRGITVENAFSLFSAA 479
Query: 774 KIHNAPELALFCEGFFLKHMKALLEQDAFRQL 805
++A +L FC F + H+ + + AF Q+
Sbjct: 480 VRYDAEDLEEFCFKFCINHLTEVTQTAAFWQM 511
>gi|4557445 regulator of chromosome condensation and BTB domain
containing protein 2 [Homo sapiens]
Length = 551
Score = 75.9 bits (185), Expect = 1e-13
Identities = 44/168 (26%), Positives = 86/168 (51%), Gaps = 10/168 (5%)
Query: 638 PEIRKTLPARLDPHFLNNKEMSDVTFLVEGKLFYAHKVLLVTASNRFKTLMTNKSEQDGD 697
P+ T+ L F +N + +D+ FLV+GK YAHKVLL F +S + +
Sbjct: 374 PDDHLTVAESLKREF-DNPDTADLKFLVDGKYIYAHKVLLKIRCEHF------RSSLEDN 426
Query: 698 SSKTIEISDMKYHIFQMMMQYLYYGGTESMEIPTTDILELLSAASLFQLDALQRHCEILC 757
+E+S+ Y +++ ++YLY T+S+ + + + LL A+ ++ + L++ C+
Sbjct: 427 EDDIVEMSEFSYPVYRAFLEYLY---TDSISLSPEEAVGLLDLATFYRENRLKKLCQQTI 483
Query: 758 SQTLSMESAVNTYKYAKIHNAPELALFCEGFFLKHMKALLEQDAFRQL 805
Q + E+A+ A ++A +L FC F + H+ + + F ++
Sbjct: 484 KQGICEENAIALLSAAVKYDAQDLEEFCFRFCINHLTVVTQTSGFAEM 531
>gi|38683807 ankyrin repeat domain protein 17 isoform a [Homo sapiens]
Length = 2603
Score = 72.0 bits (175), Expect = 2e-12
Identities = 50/147 (34%), Positives = 76/147 (51%), Gaps = 28/147 (19%)
Query: 338 TPLMYACAAGDEAMVQMLIDAGANLDIQVPSNSPRHPSIHPDSRHWTSLTFAVLHGHISV 397
T L ACA G E +VQ L++ GA+++ H D + +T L A GH+ V
Sbjct: 1085 TALTLACAGGHEELVQTLLERGASIE-------------HRDKKGFTPLILAATAGHVGV 1131
Query: 398 VQLLLDAGAHVEGSAVNGGEDSYAETPLQLASAAGNYELVSLLLSRGADPLLSMLEAHGM 457
V++LLD GA +E + + +TPL LA + G E+V LLL+RGA+ + H
Sbjct: 1132 VEILLDNGADIEAQS-----ERTKDTPLSLACSGGRQEVVELLLARGAN------KEHRN 1180
Query: 458 GSSLHEDMNCFSHSAAHGHRNVLRKLL 484
S D S +A+ G+ N+++ LL
Sbjct: 1181 VS----DYTPLSLAASGGYVNIIKILL 1203
Score = 61.6 bits (148), Expect = 3e-09
Identities = 60/220 (27%), Positives = 92/220 (41%), Gaps = 60/220 (27%)
Query: 329 VNTMDDQGMTPLMYACAAGDEAMVQMLIDAGANLDIQ--------VPSNSPRHPSI---- 376
VN G T L YACA G +V++L+++GA+++ + + S H +
Sbjct: 327 VNAQSSTGNTALTYACAGGYVDVVKVLLESGASIEDHNENGHTPLMEAGSAGHVEVARLL 386
Query: 377 ---------HPDSRHWTSLTFAVLHGHISVVQLLLDAGA--------------------H 407
H + ++LT A GH+ +V+ LL+AGA H
Sbjct: 387 LENGAGINTHSNEFKESALTLACYKGHLEMVRFLLEAGADQEHKTDEMHTALMEACMDGH 446
Query: 408 VE--------GSAVNGGEDSYAETPLQLASAAGNYELVSLLLSRGADPLLSMLEAHGMGS 459
VE G+ VN DS+ E+PL LA+ G+ EL +LL+ RGA S+ E +
Sbjct: 447 VEVARLLLDSGAQVNMPADSF-ESPLTLAACGGHVELAALLIERGA----SLEEVN---- 497
Query: 460 SLHEDMNCFSHSAAHGHRNVLRKLLTQPQQAKADVLSLEE 499
E +A GH ++ LL Q A +E
Sbjct: 498 --DEGYTPLMEAAREGHEEMVALLLGQGANINAQTEETQE 535
Score = 59.7 bits (143), Expect = 1e-08
Identities = 50/182 (27%), Positives = 85/182 (46%), Gaps = 29/182 (15%)
Query: 312 GRTDLINQAIEALGPDGVNTMDDQGMTPLMYACAAGDEAMVQMLIDAGANLDIQVPSNSP 371
GRT++++ ++ V G+TPLM A + G + ++L+D GA++ N+P
Sbjct: 1263 GRTEVVSLLLDRKA--NVEHRAKTGLTPLMEAASGGYAEVGRVLLDKGADV------NAP 1314
Query: 372 RHPSIHPDSRHWTSLTFAVLHGHISVVQLLLDAGAHVEGSAVNGGEDSYAETPLQLASAA 431
PS T+LT A GH +LL+ GAH++ G TPL LA+
Sbjct: 1315 PVPSSRD-----TALTIAADKGHYKFCELLIGRGAHIDVRNKKGN------TPLWLAANG 1363
Query: 432 GNYELVSLLLSRGADPLLSMLEAHGMGSSLHEDMNCFSHSAAHGHRNVLRKLLTQPQQAK 491
G+ ++V LL+ GAD + ++ + + + GH V+R L+ + Q
Sbjct: 1364 GHLDVVQLLVQAGAD----------VDAADNRKITPLMAAFRKGHVKVVRYLVKEVNQFP 1413
Query: 492 AD 493
+D
Sbjct: 1414 SD 1415
Score = 58.9 bits (141), Expect = 2e-08
Identities = 61/232 (26%), Positives = 97/232 (41%), Gaps = 35/232 (15%)
Query: 279 LKPEHCFSSFRRLDARAATEKFNQDLGFRMLNCGRTDLINQAIEALGPDGVNTMDDQGMT 338
+ P + +D A TE N D + G + + Q + G + D +G T
Sbjct: 1061 ISPSAMLPIYPAIDIDAQTES-NHDTALTLACAGGHEELVQTLLERGAS-IEHRDKKGFT 1118
Query: 339 PLMYACAAGDEAMVQMLIDAGANLDIQVPSNSPRHPSIHPDSRHWTSLTFAVLHGHISVV 398
PL+ A AG +V++L+D GA+++ Q T L+ A G VV
Sbjct: 1119 PLILAATAGHVGVVEILLDNGADIEAQSERTKD------------TPLSLACSGGRQEVV 1166
Query: 399 QLLLDAGAHVEGSAVNGGEDSYAETPLQLASAAGNYELVSLLLSRGAD------------ 446
+LLL GA+ E V+ TPL LA++ G ++ +LL+ GA+
Sbjct: 1167 ELLLARGANKEHRNVSD------YTPLSLAASGGYVNIIKILLNAGAEINSRTGSKLGIS 1220
Query: 447 PL-LSMLEAHGMGSSLHEDMNCFSHSAAHGHRNVLRKLLTQPQQAKADVLSL 497
PL L+ + H L DM ++ +RN L Q + +V+SL
Sbjct: 1221 PLMLAAMNGHTAAVKLLLDMGSDINAQIETNRNTALTLAC--FQGRTEVVSL 1270
Score = 58.5 bits (140), Expect = 2e-08
Identities = 47/152 (30%), Positives = 63/152 (41%), Gaps = 28/152 (18%)
Query: 336 GMTPLMYACAAGDEAMVQMLIDAGANLDIQVPSNSPRHPSIHPDSRHWTSLTFAVLHGHI 395
G T L YAC G + +L+ AGA+L+ H T L A GH+
Sbjct: 597 GDTALTYACENGHTDVADVLLQAGADLE-------------HESEGGRTPLMKAARAGHV 643
Query: 396 SVVQLLLDAGAHVEGSAVNGGEDSYAETPLQLASAAGNYELVSLLLSRGADPLLSMLEAH 455
VQ L+ GA+V + N T L LA A G+ +V LLL+ GADP
Sbjct: 644 CTVQFLISKGANVNRTTANNDH-----TVLSLACAGGHLAVVELLLAHGADPT------- 691
Query: 456 GMGSSLHEDMNCFSHSAAHGHRNVLRKLLTQP 487
L + +A GH +V+ LL P
Sbjct: 692 ---HRLKDGSTMLIEAAKGGHTSVVCYLLDYP 720
Score = 57.8 bits (138), Expect = 4e-08
Identities = 39/115 (33%), Positives = 55/115 (47%), Gaps = 21/115 (18%)
Query: 332 MDDQGMTPLMYACAAGDEAMVQMLIDAGANLDIQVPSNSPRHPSIHPDSRHWTSLTFAVL 391
++D+G TPLM A G E MV +L+ GAN++ Q + T+LT A
Sbjct: 496 VNDEGYTPLMEAAREGHEEMVALLLGQGANINAQT------------EETQETALTLACC 543
Query: 392 HGHISVVQLLLDAGAHVEGSAVNGGEDSYAETPLQLASAAGNYELVSLLLSRGAD 446
G + V L+ AGA +E TPL A+ G+ ELV LL+ GA+
Sbjct: 544 GGFLEVADFLIKAGADIELG---------CSTPLMEAAQEGHLELVKYLLAAGAN 589
Score = 50.8 bits (120), Expect = 5e-06
Identities = 41/138 (29%), Positives = 66/138 (47%), Gaps = 27/138 (19%)
Query: 329 VNTMDDQGMTPLMYACAAGDEAMVQMLIDAGANLDIQ---------VPSNSPRHPSI--- 376
VN ++G + L AC+AG + Q+L+ AN++ + + + + H I
Sbjct: 260 VNEHTEEGESLLCLACSAGYYELAQVLLAMHANVEDRGIKGDITPLMAAANGGHVKIVKL 319
Query: 377 ---------HPDSRHWTSLTFAVLHGHISVVQLLLDAGAHVEGSAVNGGEDSYAETPLQL 427
S T+LT+A G++ VV++LL++GA +E NG TPL
Sbjct: 320 LLAHKADVNAQSSTGNTALTYACAGGYVDVVKVLLESGASIEDHNENG------HTPLME 373
Query: 428 ASAAGNYELVSLLLSRGA 445
A +AG+ E+ LLL GA
Sbjct: 374 AGSAGHVEVARLLLENGA 391
Score = 45.1 bits (105), Expect = 3e-04
Identities = 42/130 (32%), Positives = 59/130 (45%), Gaps = 20/130 (15%)
Query: 312 GRTDLINQAIEALGPDGVNTMDDQGMTPLMYACAAGDEAMVQMLIDAGANLDIQVPSNSP 371
G TD+ + ++A G D + + G TPLM A AG VQ LI GAN++ +N
Sbjct: 608 GHTDVADVLLQA-GAD-LEHESEGGRTPLMKAARAGHVCTVQFLISKGANVNRTTANND- 664
Query: 372 RHPSIHPDSRHWTSLTFAVLHGHISVVQLLLDAGAHVEGSAVNGGEDSYAETPLQLASAA 431
T L+ A GH++VV+LLL GA +G T L A+
Sbjct: 665 -----------HTVLSLACAGGHLAVVELLLAHGADPTHRLKDG------STMLIEAAKG 707
Query: 432 GNYELVSLLL 441
G+ +V LL
Sbjct: 708 GHTSVVCYLL 717
Score = 34.7 bits (78), Expect = 0.38
Identities = 29/107 (27%), Positives = 46/107 (42%), Gaps = 18/107 (16%)
Query: 340 LMYACAAGDEAMVQMLIDAGANLDIQVPSNSPRHPSIHPDSRHWTSLTFAVLHGHISVVQ 399
L AC+ GD V+ L+ G +++ + L A G+ + Q
Sbjct: 238 LAEACSEGDVNAVRKLLIEGRSVNEHTEEGE-------------SLLCLACSAGYYELAQ 284
Query: 400 LLLDAGAHVEGSAVNGGEDSYAETPLQLASAAGNYELVSLLLSRGAD 446
+LL A+VE + G TPL A+ G+ ++V LLL+ AD
Sbjct: 285 VLLAMHANVEDRGIKGDI-----TPLMAAANGGHVKIVKLLLAHKAD 326
>gi|38683816 ankyrin repeat domain protein 17 isoform b [Homo
sapiens]
Length = 2352
Score = 72.0 bits (175), Expect = 2e-12
Identities = 50/147 (34%), Positives = 76/147 (51%), Gaps = 28/147 (19%)
Query: 338 TPLMYACAAGDEAMVQMLIDAGANLDIQVPSNSPRHPSIHPDSRHWTSLTFAVLHGHISV 397
T L ACA G E +VQ L++ GA+++ H D + +T L A GH+ V
Sbjct: 834 TALTLACAGGHEELVQTLLERGASIE-------------HRDKKGFTPLILAATAGHVGV 880
Query: 398 VQLLLDAGAHVEGSAVNGGEDSYAETPLQLASAAGNYELVSLLLSRGADPLLSMLEAHGM 457
V++LLD GA +E + + +TPL LA + G E+V LLL+RGA+ + H
Sbjct: 881 VEILLDNGADIEAQS-----ERTKDTPLSLACSGGRQEVVELLLARGAN------KEHRN 929
Query: 458 GSSLHEDMNCFSHSAAHGHRNVLRKLL 484
S D S +A+ G+ N+++ LL
Sbjct: 930 VS----DYTPLSLAASGGYVNIIKILL 952
Score = 61.6 bits (148), Expect = 3e-09
Identities = 60/220 (27%), Positives = 92/220 (41%), Gaps = 60/220 (27%)
Query: 329 VNTMDDQGMTPLMYACAAGDEAMVQMLIDAGANLDIQ--------VPSNSPRHPSI---- 376
VN G T L YACA G +V++L+++GA+++ + + S H +
Sbjct: 327 VNAQSSTGNTALTYACAGGYVDVVKVLLESGASIEDHNENGHTPLMEAGSAGHVEVARLL 386
Query: 377 ---------HPDSRHWTSLTFAVLHGHISVVQLLLDAGA--------------------H 407
H + ++LT A GH+ +V+ LL+AGA H
Sbjct: 387 LENGAGINTHSNEFKESALTLACYKGHLEMVRFLLEAGADQEHKTDEMHTALMEACMDGH 446
Query: 408 VE--------GSAVNGGEDSYAETPLQLASAAGNYELVSLLLSRGADPLLSMLEAHGMGS 459
VE G+ VN DS+ E+PL LA+ G+ EL +LL+ RGA S+ E +
Sbjct: 447 VEVARLLLDSGAQVNMPADSF-ESPLTLAACGGHVELAALLIERGA----SLEEVN---- 497
Query: 460 SLHEDMNCFSHSAAHGHRNVLRKLLTQPQQAKADVLSLEE 499
E +A GH ++ LL Q A +E
Sbjct: 498 --DEGYTPLMEAAREGHEEMVALLLGQGANINAQTEETQE 535
Score = 59.7 bits (143), Expect = 1e-08
Identities = 50/182 (27%), Positives = 85/182 (46%), Gaps = 29/182 (15%)
Query: 312 GRTDLINQAIEALGPDGVNTMDDQGMTPLMYACAAGDEAMVQMLIDAGANLDIQVPSNSP 371
GRT++++ ++ V G+TPLM A + G + ++L+D GA++ N+P
Sbjct: 1012 GRTEVVSLLLDRKA--NVEHRAKTGLTPLMEAASGGYAEVGRVLLDKGADV------NAP 1063
Query: 372 RHPSIHPDSRHWTSLTFAVLHGHISVVQLLLDAGAHVEGSAVNGGEDSYAETPLQLASAA 431
PS T+LT A GH +LL+ GAH++ G TPL LA+
Sbjct: 1064 PVPSSRD-----TALTIAADKGHYKFCELLIGRGAHIDVRNKKGN------TPLWLAANG 1112
Query: 432 GNYELVSLLLSRGADPLLSMLEAHGMGSSLHEDMNCFSHSAAHGHRNVLRKLLTQPQQAK 491
G+ ++V LL+ GAD + ++ + + + GH V+R L+ + Q
Sbjct: 1113 GHLDVVQLLVQAGAD----------VDAADNRKITPLMAAFRKGHVKVVRYLVKEVNQFP 1162
Query: 492 AD 493
+D
Sbjct: 1163 SD 1164
Score = 58.9 bits (141), Expect = 2e-08
Identities = 61/232 (26%), Positives = 97/232 (41%), Gaps = 35/232 (15%)
Query: 279 LKPEHCFSSFRRLDARAATEKFNQDLGFRMLNCGRTDLINQAIEALGPDGVNTMDDQGMT 338
+ P + +D A TE N D + G + + Q + G + D +G T
Sbjct: 810 ISPSAMLPIYPAIDIDAQTES-NHDTALTLACAGGHEELVQTLLERGAS-IEHRDKKGFT 867
Query: 339 PLMYACAAGDEAMVQMLIDAGANLDIQVPSNSPRHPSIHPDSRHWTSLTFAVLHGHISVV 398
PL+ A AG +V++L+D GA+++ Q T L+ A G VV
Sbjct: 868 PLILAATAGHVGVVEILLDNGADIEAQSERTKD------------TPLSLACSGGRQEVV 915
Query: 399 QLLLDAGAHVEGSAVNGGEDSYAETPLQLASAAGNYELVSLLLSRGAD------------ 446
+LLL GA+ E V+ TPL LA++ G ++ +LL+ GA+
Sbjct: 916 ELLLARGANKEHRNVSD------YTPLSLAASGGYVNIIKILLNAGAEINSRTGSKLGIS 969
Query: 447 PL-LSMLEAHGMGSSLHEDMNCFSHSAAHGHRNVLRKLLTQPQQAKADVLSL 497
PL L+ + H L DM ++ +RN L Q + +V+SL
Sbjct: 970 PLMLAAMNGHTAAVKLLLDMGSDINAQIETNRNTALTLAC--FQGRTEVVSL 1019
Score = 58.5 bits (140), Expect = 2e-08
Identities = 47/152 (30%), Positives = 63/152 (41%), Gaps = 28/152 (18%)
Query: 336 GMTPLMYACAAGDEAMVQMLIDAGANLDIQVPSNSPRHPSIHPDSRHWTSLTFAVLHGHI 395
G T L YAC G + +L+ AGA+L+ H T L A GH+
Sbjct: 597 GDTALTYACENGHTDVADVLLQAGADLE-------------HESEGGRTPLMKAARAGHV 643
Query: 396 SVVQLLLDAGAHVEGSAVNGGEDSYAETPLQLASAAGNYELVSLLLSRGADPLLSMLEAH 455
VQ L+ GA+V + N T L LA A G+ +V LLL+ GADP
Sbjct: 644 CTVQFLISKGANVNRTTANNDH-----TVLSLACAGGHLAVVELLLAHGADPT------- 691
Query: 456 GMGSSLHEDMNCFSHSAAHGHRNVLRKLLTQP 487
L + +A GH +V+ LL P
Sbjct: 692 ---HRLKDGSTMLIEAAKGGHTSVVCYLLDYP 720
Score = 57.8 bits (138), Expect = 4e-08
Identities = 39/115 (33%), Positives = 55/115 (47%), Gaps = 21/115 (18%)
Query: 332 MDDQGMTPLMYACAAGDEAMVQMLIDAGANLDIQVPSNSPRHPSIHPDSRHWTSLTFAVL 391
++D+G TPLM A G E MV +L+ GAN++ Q + T+LT A
Sbjct: 496 VNDEGYTPLMEAAREGHEEMVALLLGQGANINAQT------------EETQETALTLACC 543
Query: 392 HGHISVVQLLLDAGAHVEGSAVNGGEDSYAETPLQLASAAGNYELVSLLLSRGAD 446
G + V L+ AGA +E TPL A+ G+ ELV LL+ GA+
Sbjct: 544 GGFLEVADFLIKAGADIELG---------CSTPLMEAAQEGHLELVKYLLAAGAN 589
Score = 50.8 bits (120), Expect = 5e-06
Identities = 41/138 (29%), Positives = 66/138 (47%), Gaps = 27/138 (19%)
Query: 329 VNTMDDQGMTPLMYACAAGDEAMVQMLIDAGANLDIQ---------VPSNSPRHPSI--- 376
VN ++G + L AC+AG + Q+L+ AN++ + + + + H I
Sbjct: 260 VNEHTEEGESLLCLACSAGYYELAQVLLAMHANVEDRGIKGDITPLMAAANGGHVKIVKL 319
Query: 377 ---------HPDSRHWTSLTFAVLHGHISVVQLLLDAGAHVEGSAVNGGEDSYAETPLQL 427
S T+LT+A G++ VV++LL++GA +E NG TPL
Sbjct: 320 LLAHKADVNAQSSTGNTALTYACAGGYVDVVKVLLESGASIEDHNENG------HTPLME 373
Query: 428 ASAAGNYELVSLLLSRGA 445
A +AG+ E+ LLL GA
Sbjct: 374 AGSAGHVEVARLLLENGA 391
Score = 45.1 bits (105), Expect = 3e-04
Identities = 42/130 (32%), Positives = 59/130 (45%), Gaps = 20/130 (15%)
Query: 312 GRTDLINQAIEALGPDGVNTMDDQGMTPLMYACAAGDEAMVQMLIDAGANLDIQVPSNSP 371
G TD+ + ++A G D + + G TPLM A AG VQ LI GAN++ +N
Sbjct: 608 GHTDVADVLLQA-GAD-LEHESEGGRTPLMKAARAGHVCTVQFLISKGANVNRTTANND- 664
Query: 372 RHPSIHPDSRHWTSLTFAVLHGHISVVQLLLDAGAHVEGSAVNGGEDSYAETPLQLASAA 431
T L+ A GH++VV+LLL GA +G T L A+
Sbjct: 665 -----------HTVLSLACAGGHLAVVELLLAHGADPTHRLKDG------STMLIEAAKG 707
Query: 432 GNYELVSLLL 441
G+ +V LL
Sbjct: 708 GHTSVVCYLL 717
Score = 34.7 bits (78), Expect = 0.38
Identities = 29/107 (27%), Positives = 46/107 (42%), Gaps = 18/107 (16%)
Query: 340 LMYACAAGDEAMVQMLIDAGANLDIQVPSNSPRHPSIHPDSRHWTSLTFAVLHGHISVVQ 399
L AC+ GD V+ L+ G +++ + L A G+ + Q
Sbjct: 238 LAEACSEGDVNAVRKLLIEGRSVNEHTEEGE-------------SLLCLACSAGYYELAQ 284
Query: 400 LLLDAGAHVEGSAVNGGEDSYAETPLQLASAAGNYELVSLLLSRGAD 446
+LL A+VE + G TPL A+ G+ ++V LLL+ AD
Sbjct: 285 VLLAMHANVEDRGIKGDI-----TPLMAAANGGHVKIVKLLLAHKAD 326
>gi|11056006 kelch-like 12 [Homo sapiens]
Length = 568
Score = 69.7 bits (169), Expect = 1e-11
Identities = 48/197 (24%), Positives = 91/197 (46%), Gaps = 17/197 (8%)
Query: 624 IFTHCYGSSPIPSIPEIRKTLPARLDPHFLNNKEMSDVTFLVEGKLFYAHKVLLVTASNR 683
I T+ + S + S+ +RK+ + DVT VE K F AH+++L S+
Sbjct: 10 IMTNTHAKSILNSMNSLRKS------------NTLCDVTLRVEQKDFPAHRIVLAACSDY 57
Query: 684 FKTLMTNKSEQDGDSSKTIEISDMKYHIFQMMMQYLYYGGTESMEIPTTDILELLSAASL 743
F + T++ + G ++I + ++++ ++Y TE++ + ++ ELL AA L
Sbjct: 58 FCAMFTSELSEKG--KPYVDIQGLTASTMEILLDFVY---TETVHVTVENVQELLPAACL 112
Query: 744 FQLDALQRHCEILCSQTLSMESAVNTYKYAKIHNAPELALFCEGFFLKHMKALLEQDAFR 803
QL +++ C L + + +A+ HN +L E F KH +++ + F
Sbjct: 113 LQLKGVKQACCEFLESQLDPSNCLGIRDFAETHNCVDLMQAAEVFSQKHFPEVVQHEEFI 172
Query: 804 QLIYGRSSKVQGLDPLQ 820
L G K+ D +Q
Sbjct: 173 LLSQGEVEKLIKCDEIQ 189
>gi|67906195 ankyrin repeat and sterile alpha motif domain
containing 6 [Homo sapiens]
Length = 871
Score = 68.6 bits (166), Expect = 2e-11
Identities = 74/233 (31%), Positives = 101/233 (43%), Gaps = 44/233 (18%)
Query: 257 DSGDIRQAARLLLPGLDCEPRQLKPEHCFSSFRRLDARAATEKFNQDLGFRMLNCGRTDL 316
D GD A RLL PG EP + R + A E G + G
Sbjct: 18 DQGDTETARRLLEPGA-AEPAE----------RGAEPEAGAEP----AGAEVAGPGAA-- 60
Query: 317 INQAIEALG-PDGVNTMDDQGMTPLMYACAAGDEAMVQMLIDAGANLDIQVPSNSPRHPS 375
A A+G P V+ D+ G T L +A A G E +V+ L+ GA++ NS H
Sbjct: 61 ---AAGAVGAPVPVDCSDEAGNTALQFAAAGGHEPLVRFLLRRGASV------NSRNHYG 111
Query: 376 IHPDSRHWTSLTFAVLHGHISVVQLLLDAGAHVEGSAVNGGEDSYAETPLQLASAAGNYE 435
W++L A GH+SV LLLD GA V ++ + L +AS G+
Sbjct: 112 -------WSALMQAARFGHVSVAHLLLDHGADV------NAQNRLGASVLTVASRGGHLG 158
Query: 436 LVSLLLSRGA--DPLLSMLEAHGMGSSLHEDMNCFSHSAA--HGHRNVLRKLL 484
+V LLL GA D E G+G S E ++ + AA HGH V+R L+
Sbjct: 159 VVKLLLEAGAFVDHHHPSGEQLGLGGSRDEPLDITALMAAIQHGHEAVVRLLM 211
Score = 61.6 bits (148), Expect = 3e-09
Identities = 55/172 (31%), Positives = 77/172 (44%), Gaps = 22/172 (12%)
Query: 272 LDCEPRQLKPEHCFSSFRRLDARAATEKFNQDLGFRMLNCGRTDLINQAIEALGPDGVNT 331
LDC+ R L + + EK D+ F L G L+ + + P VN
Sbjct: 266 LDCKHRDLVDY--LDPLTTVRPKTDEEKRRPDI-FHALKMGNFQLVKEIADE-DPSHVNL 321
Query: 332 MDDQGMTPLMYACAAGDEAMVQMLIDAGANLDIQVPSNSPRHPSIHPDSRH-WTSLTFAV 390
++ G TPLM A G A+VQ+L++ A++D Q DS H WT+L A
Sbjct: 322 VNGDGATPLMLAAVTGQLALVQLLVERHADVDKQ-------------DSVHGWTALMQAT 368
Query: 391 LHGHISVVQLLLDAGAHVEGSAVNGGEDSYAETPLQLASAAGNYELVSLLLS 442
HG+ +V+ LL+ GA V A NG Y L + + ELV LL S
Sbjct: 369 YHGNKEIVKYLLNQGADVTLRAKNG----YTAFDLVMLLNDPDTELVRLLAS 416
Score = 37.4 bits (85), Expect = 0.058
Identities = 35/141 (24%), Positives = 65/141 (46%), Gaps = 18/141 (12%)
Query: 309 LNCGRTDLINQAIEALGPDGVNTMDDQGMTPLMYACAAGDEAMVQMLIDAGANLDIQVPS 368
L+C DL++ ++ L T +++ + +A G+ +V+ + D
Sbjct: 266 LDCKHRDLVDY-LDPLTTVRPKTDEEKRRPDIFHALKMGNFQLVKEIAD----------- 313
Query: 369 NSPRHPSIHPDSRHWTSLTFAVLHGHISVVQLLLDAGAHVEGSAVNGGEDSYAETPLQLA 428
P H ++ + T L A + G +++VQLL++ A V+ + + T L A
Sbjct: 314 EDPSHVNL-VNGDGATPLMLAAVTGQLALVQLLVERHADVDKQ-----DSVHGWTALMQA 367
Query: 429 SAAGNYELVSLLLSRGADPLL 449
+ GN E+V LL++GAD L
Sbjct: 368 TYHGNKEIVKYLLNQGADVTL 388
Score = 35.0 bits (79), Expect = 0.29
Identities = 32/115 (27%), Positives = 56/115 (48%), Gaps = 23/115 (20%)
Query: 337 MTPLMYACAAGDEAMVQMLIDAGANLDIQVPSNSPRHPSIHPDSRHWTSLTFAVLHGHIS 396
+T LM A G EA+V++L++ GA+ P+++ R W+ L A L G +
Sbjct: 192 ITALMAAIQHGHEAVVRLLMEWGAD-----PNHAARTVG-------WSPLMLAALTGRLG 239
Query: 397 VVQLLLDAGAHVEGSAVNGGEDSYAETPLQLASAAGNYELVSLLLSRGADPLLSM 451
V Q L++ GA+ + +V +T ++A + +LV L DPL ++
Sbjct: 240 VAQQLVEKGANPDHLSV------LEKTAFEVALDCKHRDLVDYL-----DPLTTV 283
>gi|56117834 speckle-type POZ protein [Homo sapiens]
Length = 374
Score = 67.0 bits (162), Expect = 7e-11
Identities = 41/152 (26%), Positives = 73/152 (48%), Gaps = 5/152 (3%)
Query: 655 NKEMSDVTFLVEGKLFYAHKVLLVTASNRFKTLMTNKSEQDGDSSKTIEISDMKYHIFQM 714
N +D V G+ F AHK +L S F + ++ E+ +EI+D++ +F+
Sbjct: 196 NSRFTDCCLCVAGQEFQAHKAILAARSPVFSAMFEHEMEES--KKNRVEINDVEPEVFKE 253
Query: 715 MMQYLYYGGTESMEIPTTDILELLSAASLFQLDALQRHCEILCSQTLSMESAVNTYKYAK 774
MM ++Y G +++ D LL+AA + L+ L+ CE LS+E+A A
Sbjct: 254 MMCFIYTGKAPNLDKMADD---LLAAADKYALERLKVMCEDALCSNLSVENAAEILILAD 310
Query: 775 IHNAPELALFCEGFFLKHMKALLEQDAFRQLI 806
+H+A +L F H +LE ++ ++
Sbjct: 311 LHSADQLKTQAVDFINYHASDVLETSGWKSMV 342
>gi|56117832 speckle-type POZ protein [Homo sapiens]
Length = 374
Score = 67.0 bits (162), Expect = 7e-11
Identities = 41/152 (26%), Positives = 73/152 (48%), Gaps = 5/152 (3%)
Query: 655 NKEMSDVTFLVEGKLFYAHKVLLVTASNRFKTLMTNKSEQDGDSSKTIEISDMKYHIFQM 714
N +D V G+ F AHK +L S F + ++ E+ +EI+D++ +F+
Sbjct: 196 NSRFTDCCLCVAGQEFQAHKAILAARSPVFSAMFEHEMEES--KKNRVEINDVEPEVFKE 253
Query: 715 MMQYLYYGGTESMEIPTTDILELLSAASLFQLDALQRHCEILCSQTLSMESAVNTYKYAK 774
MM ++Y G +++ D LL+AA + L+ L+ CE LS+E+A A
Sbjct: 254 MMCFIYTGKAPNLDKMADD---LLAAADKYALERLKVMCEDALCSNLSVENAAEILILAD 310
Query: 775 IHNAPELALFCEGFFLKHMKALLEQDAFRQLI 806
+H+A +L F H +LE ++ ++
Sbjct: 311 LHSADQLKTQAVDFINYHASDVLETSGWKSMV 342
>gi|56117830 speckle-type POZ protein [Homo sapiens]
Length = 374
Score = 67.0 bits (162), Expect = 7e-11
Identities = 41/152 (26%), Positives = 73/152 (48%), Gaps = 5/152 (3%)
Query: 655 NKEMSDVTFLVEGKLFYAHKVLLVTASNRFKTLMTNKSEQDGDSSKTIEISDMKYHIFQM 714
N +D V G+ F AHK +L S F + ++ E+ +EI+D++ +F+
Sbjct: 196 NSRFTDCCLCVAGQEFQAHKAILAARSPVFSAMFEHEMEES--KKNRVEINDVEPEVFKE 253
Query: 715 MMQYLYYGGTESMEIPTTDILELLSAASLFQLDALQRHCEILCSQTLSMESAVNTYKYAK 774
MM ++Y G +++ D LL+AA + L+ L+ CE LS+E+A A
Sbjct: 254 MMCFIYTGKAPNLDKMADD---LLAAADKYALERLKVMCEDALCSNLSVENAAEILILAD 310
Query: 775 IHNAPELALFCEGFFLKHMKALLEQDAFRQLI 806
+H+A +L F H +LE ++ ++
Sbjct: 311 LHSADQLKTQAVDFINYHASDVLETSGWKSMV 342
>gi|56117828 speckle-type POZ protein [Homo sapiens]
Length = 374
Score = 67.0 bits (162), Expect = 7e-11
Identities = 41/152 (26%), Positives = 73/152 (48%), Gaps = 5/152 (3%)
Query: 655 NKEMSDVTFLVEGKLFYAHKVLLVTASNRFKTLMTNKSEQDGDSSKTIEISDMKYHIFQM 714
N +D V G+ F AHK +L S F + ++ E+ +EI+D++ +F+
Sbjct: 196 NSRFTDCCLCVAGQEFQAHKAILAARSPVFSAMFEHEMEES--KKNRVEINDVEPEVFKE 253
Query: 715 MMQYLYYGGTESMEIPTTDILELLSAASLFQLDALQRHCEILCSQTLSMESAVNTYKYAK 774
MM ++Y G +++ D LL+AA + L+ L+ CE LS+E+A A
Sbjct: 254 MMCFIYTGKAPNLDKMADD---LLAAADKYALERLKVMCEDALCSNLSVENAAEILILAD 310
Query: 775 IHNAPELALFCEGFFLKHMKALLEQDAFRQLI 806
+H+A +L F H +LE ++ ++
Sbjct: 311 LHSADQLKTQAVDFINYHASDVLETSGWKSMV 342
>gi|4507183 speckle-type POZ protein [Homo sapiens]
Length = 374
Score = 67.0 bits (162), Expect = 7e-11
Identities = 41/152 (26%), Positives = 73/152 (48%), Gaps = 5/152 (3%)
Query: 655 NKEMSDVTFLVEGKLFYAHKVLLVTASNRFKTLMTNKSEQDGDSSKTIEISDMKYHIFQM 714
N +D V G+ F AHK +L S F + ++ E+ +EI+D++ +F+
Sbjct: 196 NSRFTDCCLCVAGQEFQAHKAILAARSPVFSAMFEHEMEES--KKNRVEINDVEPEVFKE 253
Query: 715 MMQYLYYGGTESMEIPTTDILELLSAASLFQLDALQRHCEILCSQTLSMESAVNTYKYAK 774
MM ++Y G +++ D LL+AA + L+ L+ CE LS+E+A A
Sbjct: 254 MMCFIYTGKAPNLDKMADD---LLAAADKYALERLKVMCEDALCSNLSVENAAEILILAD 310
Query: 775 IHNAPELALFCEGFFLKHMKALLEQDAFRQLI 806
+H+A +L F H +LE ++ ++
Sbjct: 311 LHSADQLKTQAVDFINYHASDVLETSGWKSMV 342
>gi|56117836 speckle-type POZ protein [Homo sapiens]
Length = 374
Score = 67.0 bits (162), Expect = 7e-11
Identities = 41/152 (26%), Positives = 73/152 (48%), Gaps = 5/152 (3%)
Query: 655 NKEMSDVTFLVEGKLFYAHKVLLVTASNRFKTLMTNKSEQDGDSSKTIEISDMKYHIFQM 714
N +D V G+ F AHK +L S F + ++ E+ +EI+D++ +F+
Sbjct: 196 NSRFTDCCLCVAGQEFQAHKAILAARSPVFSAMFEHEMEES--KKNRVEINDVEPEVFKE 253
Query: 715 MMQYLYYGGTESMEIPTTDILELLSAASLFQLDALQRHCEILCSQTLSMESAVNTYKYAK 774
MM ++Y G +++ D LL+AA + L+ L+ CE LS+E+A A
Sbjct: 254 MMCFIYTGKAPNLDKMADD---LLAAADKYALERLKVMCEDALCSNLSVENAAEILILAD 310
Query: 775 IHNAPELALFCEGFFLKHMKALLEQDAFRQLI 806
+H+A +L F H +LE ++ ++
Sbjct: 311 LHSADQLKTQAVDFINYHASDVLETSGWKSMV 342
>gi|46519147 ankyrin repeat and KH domain containing 1 isoform 1 [Homo
sapiens]
Length = 2542
Score = 65.9 bits (159), Expect = 2e-10
Identities = 48/147 (32%), Positives = 72/147 (48%), Gaps = 28/147 (19%)
Query: 338 TPLMYACAAGDEAMVQMLIDAGANLDIQVPSNSPRHPSIHPDSRHWTSLTFAVLHGHISV 397
T L ACA G E +V +LI A ++ H D + +T L A GH+ V
Sbjct: 1057 TALTLACAGGHEELVSVLIARDAKIE-------------HRDKKGFTPLILAATAGHVGV 1103
Query: 398 VQLLLDAGAHVEGSAVNGGEDSYAETPLQLASAAGNYELVSLLLSRGADPLLSMLEAHGM 457
V++LLD G +E + + +TPL LA + G E+V LLL+RGA+ + H
Sbjct: 1104 VEILLDKGGDIEAQS-----ERTKDTPLSLACSGGRQEVVDLLLARGAN------KEHRN 1152
Query: 458 GSSLHEDMNCFSHSAAHGHRNVLRKLL 484
S D S +A+ G+ N+++ LL
Sbjct: 1153 VS----DYTPLSLAASGGYVNIIKILL 1175
Score = 63.9 bits (154), Expect = 6e-10
Identities = 57/204 (27%), Positives = 88/204 (43%), Gaps = 43/204 (21%)
Query: 321 IEALGPDGVNTMD--DQGMTPLMYACAAGDEAMVQMLIDAGANLDIQVPSNSPRHPSI-- 376
++ L +G N D + G TPLM A +AG + ++L+D GA ++ SN + ++
Sbjct: 321 VKVLLNEGANIEDHNENGHTPLMEAASAGHVEVARVLLDHGAGINTH--SNEFKESALTL 378
Query: 377 ---------------------HPDSRHWTSLTFAVLHGHISVVQLLLDAGAHVEGSAVNG 415
H T+L A + GH+ V +LLLD+GA V A
Sbjct: 379 ACYKGHLDMVRFLLEAGADQEHKTDEMHTALMEACMDGHVEVARLLLDSGAQVNMPA--- 435
Query: 416 GEDSYAETPLQLASAAGNYELVSLLLSRGADPLLSMLEAHGMGSSLHEDMNCFSHSAAHG 475
DS+ E+PL LA+ G+ EL +LL+ RGA+ + E +A G
Sbjct: 436 --DSF-ESPLTLAACGGHVELAALLIERGAN----------LEEVNDEGYTPLMEAAREG 482
Query: 476 HRNVLRKLLTQPQQAKADVLSLEE 499
H ++ LL Q A +E
Sbjct: 483 HEEMVALLLAQGANINAQTEETQE 506
Score = 61.6 bits (148), Expect = 3e-09
Identities = 52/173 (30%), Positives = 73/173 (42%), Gaps = 28/173 (16%)
Query: 329 VNTMDDQGMTPLMYACAAGDEAMVQMLIDAGANLDIQVPSNSPRHPSIHPDSRHWTSLTF 388
VN+ G T L YACA G +V++L++ GAN++ H ++ H T L
Sbjct: 298 VNSQSATGNTALTYACAGGFVDIVKVLLNEGANIE------------DHNENGH-TPLME 344
Query: 389 AVLHGHISVVQLLLDAGAHVEGSAVNGGEDSYAETPLQLASAAGNYELVSLLLSRGADPL 448
A GH+ V ++LLD GA +N + + E+ L LA G+ ++V LL GAD
Sbjct: 345 AASAGHVEVARVLLDHGA-----GINTHSNEFKESALTLACYKGHLDMVRFLLEAGADQE 399
Query: 449 LSMLEAHGMGSSLHEDMNCFSHSAAHGHRNVLRKLLTQPQQAKADVLSLEEIL 501
E H + GH V R LL Q S E L
Sbjct: 400 HKTDEMH----------TALMEACMDGHVEVARLLLDSGAQVNMPADSFESPL 442
Score = 60.5 bits (145), Expect = 6e-09
Identities = 46/159 (28%), Positives = 77/159 (48%), Gaps = 27/159 (16%)
Query: 336 GMTPLMYACAAGDEAMVQMLIDAGANLDIQVPSNSPRHPSIHPDSRHWTSLTFAVLHGHI 395
G+TPLM A + G + ++L+D GA++ N+P PS T+LT A GH
Sbjct: 1257 GLTPLMEAASGGYAEVGRVLLDKGADV------NAPPVPSSRD-----TALTIAADKGHY 1305
Query: 396 SVVQLLLDAGAHVEGSAVNGGEDSYAETPLQLASAAGNYELVSLLLSRGADPLLSMLEAH 455
+LL+ GAH++ G TPL LAS G++++V LL+ GAD
Sbjct: 1306 KFCELLIHRGAHIDVRNKKGN------TPLWLASNGGHFDVVQLLVQAGAD--------- 1350
Query: 456 GMGSSLHEDMNCFSHSAAHGHRNVLRKLLTQPQQAKADV 494
+ ++ + + + GH V++ L+ + Q +D+
Sbjct: 1351 -VDAADNRKITPLMSAFRKGHVKVVQYLVKEVNQFPSDI 1388
Score = 59.7 bits (143), Expect = 1e-08
Identities = 47/152 (30%), Positives = 63/152 (41%), Gaps = 28/152 (18%)
Query: 336 GMTPLMYACAAGDEAMVQMLIDAGANLDIQVPSNSPRHPSIHPDSRHWTSLTFAVLHGHI 395
G T L YAC G + +L+ AGA+L+ H T L A GH+
Sbjct: 568 GDTALTYACENGHTDVADVLLQAGADLE-------------HESEGGRTPLMKAARAGHL 614
Query: 396 SVVQLLLDAGAHVEGSAVNGGEDSYAETPLQLASAAGNYELVSLLLSRGADPLLSMLEAH 455
VQ L+ GA+V + N T + LA A G+ +V LLL+ GADP
Sbjct: 615 CTVQFLISKGANVNRATANNDH-----TVVSLACAGGHLAVVELLLAHGADPT------- 662
Query: 456 GMGSSLHEDMNCFSHSAAHGHRNVLRKLLTQP 487
L + +A GH NV+ LL P
Sbjct: 663 ---HRLKDGSTMLIEAAKGGHTNVVSYLLDYP 691
Score = 57.8 bits (138), Expect = 4e-08
Identities = 43/135 (31%), Positives = 64/135 (47%), Gaps = 18/135 (13%)
Query: 312 GRTDLINQAIEALGPDGVNTMDDQGMTPLMYACAAGDEAMVQMLIDAGANLDIQVPSNSP 371
G ++I + A T G++PLM A G V++L+D G++++ Q+ +N
Sbjct: 1166 GYVNIIKILLNAGAEINSRTGSKLGISPLMLAAMNGHVPAVKLLLDMGSDINAQIETNRN 1225
Query: 372 RHPSIHPDSRHWTSLTFAVLHGHISVVQLLLDAGAHVEGSAVNGGEDSYAETPLQLASAA 431
T+LT A G VV LLLD A+VE A G TPL A++
Sbjct: 1226 ------------TALTLACFQGRAEVVSLLLDRKANVEHRAKTG------LTPLMEAASG 1267
Query: 432 GNYELVSLLLSRGAD 446
G E+ +LL +GAD
Sbjct: 1268 GYAEVGRVLLDKGAD 1282
Score = 57.0 bits (136), Expect = 7e-08
Identities = 40/115 (34%), Positives = 54/115 (46%), Gaps = 21/115 (18%)
Query: 332 MDDQGMTPLMYACAAGDEAMVQMLIDAGANLDIQVPSNSPRHPSIHPDSRHWTSLTFAVL 391
++D+G TPLM A G E MV +L+ GAN++ Q + T+LT A
Sbjct: 467 VNDEGYTPLMEAAREGHEEMVALLLAQGANINAQT------------EETQETALTLACC 514
Query: 392 HGHISVVQLLLDAGAHVEGSAVNGGEDSYAETPLQLASAAGNYELVSLLLSRGAD 446
G V L+ AGA +E TPL AS G+ ELV LL+ GA+
Sbjct: 515 GGFSEVADFLIKAGADIELG---------CSTPLMEASQEGHLELVKYLLASGAN 560
Score = 53.5 bits (127), Expect = 8e-07
Identities = 51/178 (28%), Positives = 78/178 (43%), Gaps = 33/178 (18%)
Query: 333 DDQGMTPLMYACAAGDEAMVQMLIDAGANLDIQVPSNSPRHPSIHPDSRHWTSLTFAVLH 392
D +G TPL+ A AG +V++L+D G +++ Q T L+ A
Sbjct: 1085 DKKGFTPLILAATAGHVGVVEILLDKGGDIEAQSERTKD------------TPLSLACSG 1132
Query: 393 GHISVVQLLLDAGAHVEGSAVNGGEDSYAETPLQLASAAGNYELVSLLLSRGAD------ 446
G VV LLL GA+ E V+ TPL LA++ G ++ +LL+ GA+
Sbjct: 1133 GRQEVVDLLLARGANKEHRNVSD------YTPLSLAASGGYVNIIKILLNAGAEINSRTG 1186
Query: 447 ------PL-LSMLEAHGMGSSLHEDMNCFSHSAAHGHRNVLRKLLTQPQQAKADVLSL 497
PL L+ + H L DM ++ +RN L Q +A+V+SL
Sbjct: 1187 SKLGISPLMLAAMNGHVPAVKLLLDMGSDINAQIETNRNTALTLAC--FQGRAEVVSL 1242
Score = 48.1 bits (113), Expect = 3e-05
Identities = 58/220 (26%), Positives = 97/220 (44%), Gaps = 50/220 (22%)
Query: 329 VNTMDDQGMTPLMYACAAGDEAMVQMLIDAGANLDIQ---------VPSNSPRHPSI--- 376
VN ++G + L AC+AG + Q+L+ AN++ + + ++S + I
Sbjct: 231 VNEHTEEGESLLCLACSAGYYELAQVLLAMHANVEDRGNKGDITPLMAASSGGYLDIVKL 290
Query: 377 ---------HPDSRHWTSLTFAVLHGHISVVQLLLDAGAHVEGSAVNGGEDSYAETPLQL 427
+ T+LT+A G + +V++LL+ GA++E NG TPL
Sbjct: 291 LLLHDADVNSQSATGNTALTYACAGGFVDIVKVLLNEGANIEDHNENG------HTPLME 344
Query: 428 ASAAGNYELVSLLLSRGADPLLSMLEAHGMGSSLHEDMNCFSHSAA-----HGHRNVLRK 482
A++AG+ E+ +LL HG G + H N F SA GH +++R
Sbjct: 345 AASAGHVEVARVLLD------------HGAGINTHS--NEFKESALTLACYKGHLDMVRF 390
Query: 483 LLT--QPQQAKADVL--SLEEILAEGVEESDASSQGSGSE 518
LL Q+ K D + +L E +G E SG++
Sbjct: 391 LLEAGADQEHKTDEMHTALMEACMDGHVEVARLLLDSGAQ 430
Score = 46.6 bits (109), Expect = 1e-04
Identities = 30/83 (36%), Positives = 43/83 (51%), Gaps = 10/83 (12%)
Query: 368 SNSPRHPSI----HPDSRHWTSLTFAVLHGHISVVQLLLDAGAHVEGSAVNGGEDSYAET 423
S P +PS+ H +S H T+LT A GH +V +L+ A +E D T
Sbjct: 1037 SMPPVYPSVDIDAHTESNHDTALTLACAGGHEELVSVLIARDAKIE------HRDKKGFT 1090
Query: 424 PLQLASAAGNYELVSLLLSRGAD 446
PL LA+ AG+ +V +LL +G D
Sbjct: 1091 PLILAATAGHVGVVEILLDKGGD 1113
Score = 45.4 bits (106), Expect = 2e-04
Identities = 42/130 (32%), Positives = 60/130 (46%), Gaps = 20/130 (15%)
Query: 312 GRTDLINQAIEALGPDGVNTMDDQGMTPLMYACAAGDEAMVQMLIDAGANLDIQVPSNSP 371
G TD+ + ++A G D + + G TPLM A AG VQ LI GAN++ +N
Sbjct: 579 GHTDVADVLLQA-GAD-LEHESEGGRTPLMKAARAGHLCTVQFLISKGANVNRATANND- 635
Query: 372 RHPSIHPDSRHWTSLTFAVLHGHISVVQLLLDAGAHVEGSAVNGGEDSYAETPLQLASAA 431
T ++ A GH++VV+LLL GA +G T L A+
Sbjct: 636 -----------HTVVSLACAGGHLAVVELLLAHGADPTHRLKDG------STMLIEAAKG 678
Query: 432 GNYELVSLLL 441
G+ +VS LL
Sbjct: 679 GHTNVVSYLL 688
Score = 37.4 bits (85), Expect = 0.058
Identities = 24/74 (32%), Positives = 36/74 (48%), Gaps = 13/74 (17%)
Query: 329 VNTMDDQGMTPLMYACAAGDEAMVQMLIDAGANLDIQVPSNSPRHPSIHPDSRHWTSLTF 388
++ + +G TPL A G +VQ+L+ AGA++D D+R T L
Sbjct: 1318 IDVRNKKGNTPLWLASNGGHFDVVQLLVQAGADVDA-------------ADNRKITPLMS 1364
Query: 389 AVLHGHISVVQLLL 402
A GH+ VVQ L+
Sbjct: 1365 AFRKGHVKVVQYLV 1378
Score = 36.2 bits (82), Expect = 0.13
Identities = 31/107 (28%), Positives = 45/107 (42%), Gaps = 18/107 (16%)
Query: 340 LMYACAAGDEAMVQMLIDAGANLDIQVPSNSPRHPSIHPDSRHWTSLTFAVLHGHISVVQ 399
L AC+ GD V+ L+D G +++ + L A G+ + Q
Sbjct: 209 LAEACSDGDVNAVRKLLDEGRSVNEHTEEGE-------------SLLCLACSAGYYELAQ 255
Query: 400 LLLDAGAHVEGSAVNGGEDSYAETPLQLASAAGNYELVSLLLSRGAD 446
+LL A+VE G TPL AS+ G ++V LLL AD
Sbjct: 256 VLLAMHANVEDRGNKGD-----ITPLMAASSGGYLDIVKLLLLHDAD 297
>gi|37620163 ANKHD1-EIF4EBP3 protein [Homo sapiens]
Length = 2617
Score = 65.9 bits (159), Expect = 2e-10
Identities = 48/147 (32%), Positives = 72/147 (48%), Gaps = 28/147 (19%)
Query: 338 TPLMYACAAGDEAMVQMLIDAGANLDIQVPSNSPRHPSIHPDSRHWTSLTFAVLHGHISV 397
T L ACA G E +V +LI A ++ H D + +T L A GH+ V
Sbjct: 1057 TALTLACAGGHEELVSVLIARDAKIE-------------HRDKKGFTPLILAATAGHVGV 1103
Query: 398 VQLLLDAGAHVEGSAVNGGEDSYAETPLQLASAAGNYELVSLLLSRGADPLLSMLEAHGM 457
V++LLD G +E + + +TPL LA + G E+V LLL+RGA+ + H
Sbjct: 1104 VEILLDKGGDIEAQS-----ERTKDTPLSLACSGGRQEVVDLLLARGAN------KEHRN 1152
Query: 458 GSSLHEDMNCFSHSAAHGHRNVLRKLL 484
S D S +A+ G+ N+++ LL
Sbjct: 1153 VS----DYTPLSLAASGGYVNIIKILL 1175
Score = 63.9 bits (154), Expect = 6e-10
Identities = 57/204 (27%), Positives = 88/204 (43%), Gaps = 43/204 (21%)
Query: 321 IEALGPDGVNTMD--DQGMTPLMYACAAGDEAMVQMLIDAGANLDIQVPSNSPRHPSI-- 376
++ L +G N D + G TPLM A +AG + ++L+D GA ++ SN + ++
Sbjct: 321 VKVLLNEGANIEDHNENGHTPLMEAASAGHVEVARVLLDHGAGINTH--SNEFKESALTL 378
Query: 377 ---------------------HPDSRHWTSLTFAVLHGHISVVQLLLDAGAHVEGSAVNG 415
H T+L A + GH+ V +LLLD+GA V A
Sbjct: 379 ACYKGHLDMVRFLLEAGADQEHKTDEMHTALMEACMDGHVEVARLLLDSGAQVNMPA--- 435
Query: 416 GEDSYAETPLQLASAAGNYELVSLLLSRGADPLLSMLEAHGMGSSLHEDMNCFSHSAAHG 475
DS+ E+PL LA+ G+ EL +LL+ RGA+ + E +A G
Sbjct: 436 --DSF-ESPLTLAACGGHVELAALLIERGAN----------LEEVNDEGYTPLMEAAREG 482
Query: 476 HRNVLRKLLTQPQQAKADVLSLEE 499
H ++ LL Q A +E
Sbjct: 483 HEEMVALLLAQGANINAQTEETQE 506
Score = 61.6 bits (148), Expect = 3e-09
Identities = 52/173 (30%), Positives = 73/173 (42%), Gaps = 28/173 (16%)
Query: 329 VNTMDDQGMTPLMYACAAGDEAMVQMLIDAGANLDIQVPSNSPRHPSIHPDSRHWTSLTF 388
VN+ G T L YACA G +V++L++ GAN++ H ++ H T L
Sbjct: 298 VNSQSATGNTALTYACAGGFVDIVKVLLNEGANIE------------DHNENGH-TPLME 344
Query: 389 AVLHGHISVVQLLLDAGAHVEGSAVNGGEDSYAETPLQLASAAGNYELVSLLLSRGADPL 448
A GH+ V ++LLD GA +N + + E+ L LA G+ ++V LL GAD
Sbjct: 345 AASAGHVEVARVLLDHGA-----GINTHSNEFKESALTLACYKGHLDMVRFLLEAGADQE 399
Query: 449 LSMLEAHGMGSSLHEDMNCFSHSAAHGHRNVLRKLLTQPQQAKADVLSLEEIL 501
E H + GH V R LL Q S E L
Sbjct: 400 HKTDEMH----------TALMEACMDGHVEVARLLLDSGAQVNMPADSFESPL 442
Score = 60.5 bits (145), Expect = 6e-09
Identities = 46/159 (28%), Positives = 77/159 (48%), Gaps = 27/159 (16%)
Query: 336 GMTPLMYACAAGDEAMVQMLIDAGANLDIQVPSNSPRHPSIHPDSRHWTSLTFAVLHGHI 395
G+TPLM A + G + ++L+D GA++ N+P PS T+LT A GH
Sbjct: 1257 GLTPLMEAASGGYAEVGRVLLDKGADV------NAPPVPSSRD-----TALTIAADKGHY 1305
Query: 396 SVVQLLLDAGAHVEGSAVNGGEDSYAETPLQLASAAGNYELVSLLLSRGADPLLSMLEAH 455
+LL+ GAH++ G TPL LAS G++++V LL+ GAD
Sbjct: 1306 KFCELLIHRGAHIDVRNKKGN------TPLWLASNGGHFDVVQLLVQAGAD--------- 1350
Query: 456 GMGSSLHEDMNCFSHSAAHGHRNVLRKLLTQPQQAKADV 494
+ ++ + + + GH V++ L+ + Q +D+
Sbjct: 1351 -VDAADNRKITPLMSAFRKGHVKVVQYLVKEVNQFPSDI 1388
Score = 59.7 bits (143), Expect = 1e-08
Identities = 47/152 (30%), Positives = 63/152 (41%), Gaps = 28/152 (18%)
Query: 336 GMTPLMYACAAGDEAMVQMLIDAGANLDIQVPSNSPRHPSIHPDSRHWTSLTFAVLHGHI 395
G T L YAC G + +L+ AGA+L+ H T L A GH+
Sbjct: 568 GDTALTYACENGHTDVADVLLQAGADLE-------------HESEGGRTPLMKAARAGHL 614
Query: 396 SVVQLLLDAGAHVEGSAVNGGEDSYAETPLQLASAAGNYELVSLLLSRGADPLLSMLEAH 455
VQ L+ GA+V + N T + LA A G+ +V LLL+ GADP
Sbjct: 615 CTVQFLISKGANVNRATANNDH-----TVVSLACAGGHLAVVELLLAHGADPT------- 662
Query: 456 GMGSSLHEDMNCFSHSAAHGHRNVLRKLLTQP 487
L + +A GH NV+ LL P
Sbjct: 663 ---HRLKDGSTMLIEAAKGGHTNVVSYLLDYP 691
Score = 57.8 bits (138), Expect = 4e-08
Identities = 43/135 (31%), Positives = 64/135 (47%), Gaps = 18/135 (13%)
Query: 312 GRTDLINQAIEALGPDGVNTMDDQGMTPLMYACAAGDEAMVQMLIDAGANLDIQVPSNSP 371
G ++I + A T G++PLM A G V++L+D G++++ Q+ +N
Sbjct: 1166 GYVNIIKILLNAGAEINSRTGSKLGISPLMLAAMNGHVPAVKLLLDMGSDINAQIETNRN 1225
Query: 372 RHPSIHPDSRHWTSLTFAVLHGHISVVQLLLDAGAHVEGSAVNGGEDSYAETPLQLASAA 431
T+LT A G VV LLLD A+VE A G TPL A++
Sbjct: 1226 ------------TALTLACFQGRAEVVSLLLDRKANVEHRAKTG------LTPLMEAASG 1267
Query: 432 GNYELVSLLLSRGAD 446
G E+ +LL +GAD
Sbjct: 1268 GYAEVGRVLLDKGAD 1282
Score = 57.0 bits (136), Expect = 7e-08
Identities = 40/115 (34%), Positives = 54/115 (46%), Gaps = 21/115 (18%)
Query: 332 MDDQGMTPLMYACAAGDEAMVQMLIDAGANLDIQVPSNSPRHPSIHPDSRHWTSLTFAVL 391
++D+G TPLM A G E MV +L+ GAN++ Q + T+LT A
Sbjct: 467 VNDEGYTPLMEAAREGHEEMVALLLAQGANINAQT------------EETQETALTLACC 514
Query: 392 HGHISVVQLLLDAGAHVEGSAVNGGEDSYAETPLQLASAAGNYELVSLLLSRGAD 446
G V L+ AGA +E TPL AS G+ ELV LL+ GA+
Sbjct: 515 GGFSEVADFLIKAGADIELG---------CSTPLMEASQEGHLELVKYLLASGAN 560
Score = 53.5 bits (127), Expect = 8e-07
Identities = 51/178 (28%), Positives = 78/178 (43%), Gaps = 33/178 (18%)
Query: 333 DDQGMTPLMYACAAGDEAMVQMLIDAGANLDIQVPSNSPRHPSIHPDSRHWTSLTFAVLH 392
D +G TPL+ A AG +V++L+D G +++ Q T L+ A
Sbjct: 1085 DKKGFTPLILAATAGHVGVVEILLDKGGDIEAQSERTKD------------TPLSLACSG 1132
Query: 393 GHISVVQLLLDAGAHVEGSAVNGGEDSYAETPLQLASAAGNYELVSLLLSRGAD------ 446
G VV LLL GA+ E V+ TPL LA++ G ++ +LL+ GA+
Sbjct: 1133 GRQEVVDLLLARGANKEHRNVSD------YTPLSLAASGGYVNIIKILLNAGAEINSRTG 1186
Query: 447 ------PL-LSMLEAHGMGSSLHEDMNCFSHSAAHGHRNVLRKLLTQPQQAKADVLSL 497
PL L+ + H L DM ++ +RN L Q +A+V+SL
Sbjct: 1187 SKLGISPLMLAAMNGHVPAVKLLLDMGSDINAQIETNRNTALTLAC--FQGRAEVVSL 1242
Score = 48.1 bits (113), Expect = 3e-05
Identities = 58/220 (26%), Positives = 97/220 (44%), Gaps = 50/220 (22%)
Query: 329 VNTMDDQGMTPLMYACAAGDEAMVQMLIDAGANLDIQ---------VPSNSPRHPSI--- 376
VN ++G + L AC+AG + Q+L+ AN++ + + ++S + I
Sbjct: 231 VNEHTEEGESLLCLACSAGYYELAQVLLAMHANVEDRGNKGDITPLMAASSGGYLDIVKL 290
Query: 377 ---------HPDSRHWTSLTFAVLHGHISVVQLLLDAGAHVEGSAVNGGEDSYAETPLQL 427
+ T+LT+A G + +V++LL+ GA++E NG TPL
Sbjct: 291 LLLHDADVNSQSATGNTALTYACAGGFVDIVKVLLNEGANIEDHNENG------HTPLME 344
Query: 428 ASAAGNYELVSLLLSRGADPLLSMLEAHGMGSSLHEDMNCFSHSAA-----HGHRNVLRK 482
A++AG+ E+ +LL HG G + H N F SA GH +++R
Sbjct: 345 AASAGHVEVARVLLD------------HGAGINTHS--NEFKESALTLACYKGHLDMVRF 390
Query: 483 LLT--QPQQAKADVL--SLEEILAEGVEESDASSQGSGSE 518
LL Q+ K D + +L E +G E SG++
Sbjct: 391 LLEAGADQEHKTDEMHTALMEACMDGHVEVARLLLDSGAQ 430
Score = 46.6 bits (109), Expect = 1e-04
Identities = 30/83 (36%), Positives = 43/83 (51%), Gaps = 10/83 (12%)
Query: 368 SNSPRHPSI----HPDSRHWTSLTFAVLHGHISVVQLLLDAGAHVEGSAVNGGEDSYAET 423
S P +PS+ H +S H T+LT A GH +V +L+ A +E D T
Sbjct: 1037 SMPPVYPSVDIDAHTESNHDTALTLACAGGHEELVSVLIARDAKIE------HRDKKGFT 1090
Query: 424 PLQLASAAGNYELVSLLLSRGAD 446
PL LA+ AG+ +V +LL +G D
Sbjct: 1091 PLILAATAGHVGVVEILLDKGGD 1113
Score = 45.4 bits (106), Expect = 2e-04
Identities = 42/130 (32%), Positives = 60/130 (46%), Gaps = 20/130 (15%)
Query: 312 GRTDLINQAIEALGPDGVNTMDDQGMTPLMYACAAGDEAMVQMLIDAGANLDIQVPSNSP 371
G TD+ + ++A G D + + G TPLM A AG VQ LI GAN++ +N
Sbjct: 579 GHTDVADVLLQA-GAD-LEHESEGGRTPLMKAARAGHLCTVQFLISKGANVNRATANND- 635
Query: 372 RHPSIHPDSRHWTSLTFAVLHGHISVVQLLLDAGAHVEGSAVNGGEDSYAETPLQLASAA 431
T ++ A GH++VV+LLL GA +G T L A+
Sbjct: 636 -----------HTVVSLACAGGHLAVVELLLAHGADPTHRLKDG------STMLIEAAKG 678
Query: 432 GNYELVSLLL 441
G+ +VS LL
Sbjct: 679 GHTNVVSYLL 688
Score = 37.4 bits (85), Expect = 0.058
Identities = 24/74 (32%), Positives = 36/74 (48%), Gaps = 13/74 (17%)
Query: 329 VNTMDDQGMTPLMYACAAGDEAMVQMLIDAGANLDIQVPSNSPRHPSIHPDSRHWTSLTF 388
++ + +G TPL A G +VQ+L+ AGA++D D+R T L
Sbjct: 1318 IDVRNKKGNTPLWLASNGGHFDVVQLLVQAGADVDA-------------ADNRKITPLMS 1364
Query: 389 AVLHGHISVVQLLL 402
A GH+ VVQ L+
Sbjct: 1365 AFRKGHVKVVQYLV 1378
Score = 36.2 bits (82), Expect = 0.13
Identities = 31/107 (28%), Positives = 45/107 (42%), Gaps = 18/107 (16%)
Query: 340 LMYACAAGDEAMVQMLIDAGANLDIQVPSNSPRHPSIHPDSRHWTSLTFAVLHGHISVVQ 399
L AC+ GD V+ L+D G +++ + L A G+ + Q
Sbjct: 209 LAEACSDGDVNAVRKLLDEGRSVNEHTEEGE-------------SLLCLACSAGYYELAQ 255
Query: 400 LLLDAGAHVEGSAVNGGEDSYAETPLQLASAAGNYELVSLLLSRGAD 446
+LL A+VE G TPL AS+ G ++V LLL AD
Sbjct: 256 VLLAMHANVEDRGNKGD-----ITPLMAASSGGYLDIVKLLLLHDAD 297
>gi|48717263 speckle-type POZ protein-like [Homo sapiens]
Length = 392
Score = 64.7 bits (156), Expect = 3e-10
Identities = 60/226 (26%), Positives = 101/226 (44%), Gaps = 28/226 (12%)
Query: 564 ESLRTSFSQSRYSVVQS--------LLRDFSSIREEEYNEELVTEGLQLMFDILKTSKND 615
E + SQ Y VQ + RDF +E N L + L L ++
Sbjct: 112 EETKAMESQRAYRFVQGKDWGFKKFIRRDFLL---DEANGLLPDDKLTLFCEV------- 161
Query: 616 SVIQQLATIFTHCYGSSPIPSIPEIRKTLPARLDPHFLNNKEMSDVTFLVEGKLFYAHKV 675
SV+Q I H ++ +PE R A + N +D +F V G+ F AHK
Sbjct: 162 SVVQDSVNISGHT--NTNTLKVPECRL---AEDLGNLWENTRFTDCSFFVRGQEFKAHKS 216
Query: 676 LLVTASNRFKTLMTNKSEQDGDSSKTIEISDMKYHIFQMMMQYLYYGGTESMEIPTTDIL 735
+L S F + ++ E+ +EI+D+ +F+ MM+++Y G +++ +
Sbjct: 217 VLAARSPVFNAMFEHEMEES--KKNRVEINDLDPEVFKEMMRFIYTGRAPNLDKMADN-- 272
Query: 736 ELLSAASLFQLDALQRHCEILCSQTLSMESAVNTYKYAKIHNAPEL 781
LL+AA + L+ L+ CE LS+E+ +T A +H+A +L
Sbjct: 273 -LLAAADKYALERLKVMCEEALCSNLSVENVADTLVLADLHSAEQL 317
>gi|46519154 ankyrin repeat and KH domain containing 1 isoform 3
[Homo sapiens]
Length = 627
Score = 63.9 bits (154), Expect = 6e-10
Identities = 57/204 (27%), Positives = 88/204 (43%), Gaps = 43/204 (21%)
Query: 321 IEALGPDGVNTMD--DQGMTPLMYACAAGDEAMVQMLIDAGANLDIQVPSNSPRHPSI-- 376
++ L +G N D + G TPLM A +AG + ++L+D GA ++ SN + ++
Sbjct: 321 VKVLLNEGANIEDHNENGHTPLMEAASAGHVEVARVLLDHGAGINTH--SNEFKESALTL 378
Query: 377 ---------------------HPDSRHWTSLTFAVLHGHISVVQLLLDAGAHVEGSAVNG 415
H T+L A + GH+ V +LLLD+GA V A
Sbjct: 379 ACYKGHLDMVRFLLEAGADQEHKTDEMHTALMEACMDGHVEVARLLLDSGAQVNMPA--- 435
Query: 416 GEDSYAETPLQLASAAGNYELVSLLLSRGADPLLSMLEAHGMGSSLHEDMNCFSHSAAHG 475
DS+ E+PL LA+ G+ EL +LL+ RGA+ + E +A G
Sbjct: 436 --DSF-ESPLTLAACGGHVELAALLIERGAN----------LEEVNDEGYTPLMEAAREG 482
Query: 476 HRNVLRKLLTQPQQAKADVLSLEE 499
H ++ LL Q A +E
Sbjct: 483 HEEMVALLLAQGANINAQTEETQE 506
Score = 61.6 bits (148), Expect = 3e-09
Identities = 52/173 (30%), Positives = 73/173 (42%), Gaps = 28/173 (16%)
Query: 329 VNTMDDQGMTPLMYACAAGDEAMVQMLIDAGANLDIQVPSNSPRHPSIHPDSRHWTSLTF 388
VN+ G T L YACA G +V++L++ GAN++ H ++ H T L
Sbjct: 298 VNSQSATGNTALTYACAGGFVDIVKVLLNEGANIE------------DHNENGH-TPLME 344
Query: 389 AVLHGHISVVQLLLDAGAHVEGSAVNGGEDSYAETPLQLASAAGNYELVSLLLSRGADPL 448
A GH+ V ++LLD GA +N + + E+ L LA G+ ++V LL GAD
Sbjct: 345 AASAGHVEVARVLLDHGA-----GINTHSNEFKESALTLACYKGHLDMVRFLLEAGADQE 399
Query: 449 LSMLEAHGMGSSLHEDMNCFSHSAAHGHRNVLRKLLTQPQQAKADVLSLEEIL 501
E H + GH V R LL Q S E L
Sbjct: 400 HKTDEMH----------TALMEACMDGHVEVARLLLDSGAQVNMPADSFESPL 442
Score = 59.3 bits (142), Expect = 1e-08
Identities = 52/177 (29%), Positives = 80/177 (45%), Gaps = 37/177 (20%)
Query: 332 MDDQGMTPLMYACAAGDEAMVQMLIDAGANLDIQVPSNSPRHPSIHPDSRHWTSLTFAVL 391
++D+G TPLM A G E MV +L+ GAN++ Q + T+LT A
Sbjct: 467 VNDEGYTPLMEAAREGHEEMVALLLAQGANINAQT------------EETQETALTLACC 514
Query: 392 HGHISVVQLLLDAGAHVEGSAVNGGEDSYAETPLQLASAAGNYELVSLLLSRGADPLLSM 451
G V L+ AGA +E TPL AS G+ ELV LL+ GA+
Sbjct: 515 GGFSEVADFLIKAGADIELG---------CSTPLMEASQEGHLELVKYLLASGAN----- 560
Query: 452 LEAHGMGSSLHEDMNCFSHSAAHGHRNVLRKLLTQPQQAKADVLSLEEI--LAEGVE 506
+ ++ +++ +GH +V LL QA AD+ E++ + EG++
Sbjct: 561 -----VHATTATGDTALTYACENGHTDVADVLL----QAGADLDKQEDMKTILEGID 608
Score = 48.1 bits (113), Expect = 3e-05
Identities = 58/220 (26%), Positives = 97/220 (44%), Gaps = 50/220 (22%)
Query: 329 VNTMDDQGMTPLMYACAAGDEAMVQMLIDAGANLDIQ---------VPSNSPRHPSI--- 376
VN ++G + L AC+AG + Q+L+ AN++ + + ++S + I
Sbjct: 231 VNEHTEEGESLLCLACSAGYYELAQVLLAMHANVEDRGNKGDITPLMAASSGGYLDIVKL 290
Query: 377 ---------HPDSRHWTSLTFAVLHGHISVVQLLLDAGAHVEGSAVNGGEDSYAETPLQL 427
+ T+LT+A G + +V++LL+ GA++E NG TPL
Sbjct: 291 LLLHDADVNSQSATGNTALTYACAGGFVDIVKVLLNEGANIEDHNENG------HTPLME 344
Query: 428 ASAAGNYELVSLLLSRGADPLLSMLEAHGMGSSLHEDMNCFSHSAA-----HGHRNVLRK 482
A++AG+ E+ +LL HG G + H N F SA GH +++R
Sbjct: 345 AASAGHVEVARVLLD------------HGAGINTHS--NEFKESALTLACYKGHLDMVRF 390
Query: 483 LLT--QPQQAKADVL--SLEEILAEGVEESDASSQGSGSE 518
LL Q+ K D + +L E +G E SG++
Sbjct: 391 LLEAGADQEHKTDEMHTALMEACMDGHVEVARLLLDSGAQ 430
Score = 36.2 bits (82), Expect = 0.13
Identities = 31/107 (28%), Positives = 45/107 (42%), Gaps = 18/107 (16%)
Query: 340 LMYACAAGDEAMVQMLIDAGANLDIQVPSNSPRHPSIHPDSRHWTSLTFAVLHGHISVVQ 399
L AC+ GD V+ L+D G +++ + L A G+ + Q
Sbjct: 209 LAEACSDGDVNAVRKLLDEGRSVNEHTEEGE-------------SLLCLACSAGYYELAQ 255
Query: 400 LLLDAGAHVEGSAVNGGEDSYAETPLQLASAAGNYELVSLLLSRGAD 446
+LL A+VE G TPL AS+ G ++V LLL AD
Sbjct: 256 VLLAMHANVEDRGNKGD-----ITPLMAASSGGYLDIVKLLLLHDAD 297
>gi|46519151 ankyrin repeat and KH domain containing 1 isoform 2
[Homo sapiens]
Length = 616
Score = 63.9 bits (154), Expect = 6e-10
Identities = 57/204 (27%), Positives = 88/204 (43%), Gaps = 43/204 (21%)
Query: 321 IEALGPDGVNTMD--DQGMTPLMYACAAGDEAMVQMLIDAGANLDIQVPSNSPRHPSI-- 376
++ L +G N D + G TPLM A +AG + ++L+D GA ++ SN + ++
Sbjct: 310 VKVLLNEGANIEDHNENGHTPLMEAASAGHVEVARVLLDHGAGINTH--SNEFKESALTL 367
Query: 377 ---------------------HPDSRHWTSLTFAVLHGHISVVQLLLDAGAHVEGSAVNG 415
H T+L A + GH+ V +LLLD+GA V A
Sbjct: 368 ACYKGHLDMVRFLLEAGADQEHKTDEMHTALMEACMDGHVEVARLLLDSGAQVNMPA--- 424
Query: 416 GEDSYAETPLQLASAAGNYELVSLLLSRGADPLLSMLEAHGMGSSLHEDMNCFSHSAAHG 475
DS+ E+PL LA+ G+ EL +LL+ RGA+ + E +A G
Sbjct: 425 --DSF-ESPLTLAACGGHVELAALLIERGAN----------LEEVNDEGYTPLMEAAREG 471
Query: 476 HRNVLRKLLTQPQQAKADVLSLEE 499
H ++ LL Q A +E
Sbjct: 472 HEEMVALLLAQGANINAQTEETQE 495
Score = 61.6 bits (148), Expect = 3e-09
Identities = 52/173 (30%), Positives = 73/173 (42%), Gaps = 28/173 (16%)
Query: 329 VNTMDDQGMTPLMYACAAGDEAMVQMLIDAGANLDIQVPSNSPRHPSIHPDSRHWTSLTF 388
VN+ G T L YACA G +V++L++ GAN++ H ++ H T L
Sbjct: 287 VNSQSATGNTALTYACAGGFVDIVKVLLNEGANIE------------DHNENGH-TPLME 333
Query: 389 AVLHGHISVVQLLLDAGAHVEGSAVNGGEDSYAETPLQLASAAGNYELVSLLLSRGADPL 448
A GH+ V ++LLD GA +N + + E+ L LA G+ ++V LL GAD
Sbjct: 334 AASAGHVEVARVLLDHGA-----GINTHSNEFKESALTLACYKGHLDMVRFLLEAGADQE 388
Query: 449 LSMLEAHGMGSSLHEDMNCFSHSAAHGHRNVLRKLLTQPQQAKADVLSLEEIL 501
E H + GH V R LL Q S E L
Sbjct: 389 HKTDEMH----------TALMEACMDGHVEVARLLLDSGAQVNMPADSFESPL 431
Score = 59.3 bits (142), Expect = 1e-08
Identities = 52/177 (29%), Positives = 80/177 (45%), Gaps = 37/177 (20%)
Query: 332 MDDQGMTPLMYACAAGDEAMVQMLIDAGANLDIQVPSNSPRHPSIHPDSRHWTSLTFAVL 391
++D+G TPLM A G E MV +L+ GAN++ Q + T+LT A
Sbjct: 456 VNDEGYTPLMEAAREGHEEMVALLLAQGANINAQT------------EETQETALTLACC 503
Query: 392 HGHISVVQLLLDAGAHVEGSAVNGGEDSYAETPLQLASAAGNYELVSLLLSRGADPLLSM 451
G V L+ AGA +E TPL AS G+ ELV LL+ GA+
Sbjct: 504 GGFSEVADFLIKAGADIELG---------CSTPLMEASQEGHLELVKYLLASGAN----- 549
Query: 452 LEAHGMGSSLHEDMNCFSHSAAHGHRNVLRKLLTQPQQAKADVLSLEEI--LAEGVE 506
+ ++ +++ +GH +V LL QA AD+ E++ + EG++
Sbjct: 550 -----VHATTATGDTALTYACENGHTDVADVLL----QAGADLDKQEDMKTILEGID 597
Score = 48.1 bits (113), Expect = 3e-05
Identities = 58/220 (26%), Positives = 97/220 (44%), Gaps = 50/220 (22%)
Query: 329 VNTMDDQGMTPLMYACAAGDEAMVQMLIDAGANLDIQ---------VPSNSPRHPSI--- 376
VN ++G + L AC+AG + Q+L+ AN++ + + ++S + I
Sbjct: 220 VNEHTEEGESLLCLACSAGYYELAQVLLAMHANVEDRGNKGDITPLMAASSGGYLDIVKL 279
Query: 377 ---------HPDSRHWTSLTFAVLHGHISVVQLLLDAGAHVEGSAVNGGEDSYAETPLQL 427
+ T+LT+A G + +V++LL+ GA++E NG TPL
Sbjct: 280 LLLHDADVNSQSATGNTALTYACAGGFVDIVKVLLNEGANIEDHNENG------HTPLME 333
Query: 428 ASAAGNYELVSLLLSRGADPLLSMLEAHGMGSSLHEDMNCFSHSAA-----HGHRNVLRK 482
A++AG+ E+ +LL HG G + H N F SA GH +++R
Sbjct: 334 AASAGHVEVARVLLD------------HGAGINTHS--NEFKESALTLACYKGHLDMVRF 379
Query: 483 LLT--QPQQAKADVL--SLEEILAEGVEESDASSQGSGSE 518
LL Q+ K D + +L E +G E SG++
Sbjct: 380 LLEAGADQEHKTDEMHTALMEACMDGHVEVARLLLDSGAQ 419
Score = 37.0 bits (84), Expect = 0.076
Identities = 41/160 (25%), Positives = 61/160 (38%), Gaps = 21/160 (13%)
Query: 290 RLDARAATEKFNQDLGFRMLNCGRTDLINQAIEALGPDGVNTMDDQGMTP---LMYACAA 346
RL+A F R L + +++A AL + G L AC+
Sbjct: 145 RLEALLEAAAFADPEVLRRLTSSVSCALDEAAAALTRMKAENSHNAGQVDTRSLAEACSD 204
Query: 347 GDEAMVQMLIDAGANLDIQVPSNSPRHPSIHPDSRHWTSLTFAVLHGHISVVQLLLDAGA 406
GD V+ L+D G +++ + L A G+ + Q+LL A
Sbjct: 205 GDVNAVRKLLDEGRSVNEHTEEGE-------------SLLCLACSAGYYELAQVLLAMHA 251
Query: 407 HVEGSAVNGGEDSYAETPLQLASAAGNYELVSLLLSRGAD 446
+VE G TPL AS+ G ++V LLL AD
Sbjct: 252 NVEDRGNKGD-----ITPLMAASSGGYLDIVKLLLLHDAD 286
>gi|62988328 ankyrin repeat domain 50 [Homo sapiens]
Length = 1429
Score = 63.2 bits (152), Expect = 1e-09
Identities = 45/118 (38%), Positives = 57/118 (48%), Gaps = 19/118 (16%)
Query: 329 VNTMDDQGMTPLMYACAAGDEAMVQMLIDAGANLDIQVPSNSPRHPSIHPDSRHWTSLTF 388
V+ D GMTPL+ A G +V +L++ GA++D H D+ T L
Sbjct: 741 VDHCDKDGMTPLLVAAYEGHVDVVDLLLEGGADVD-------------HTDNNGRTPLLA 787
Query: 389 AVLHGHISVVQLLLDAGAHVEGSAVNGGEDSYAETPLQLASAAGNYELVSLLLSRGAD 446
A GH SVV LL GA V+ DS T L +ASA GN E+V LL RG D
Sbjct: 788 AASMGHASVVNTLLFWGAAVDSI------DSEGRTVLSIASAQGNVEVVRTLLDRGLD 839
Score = 59.3 bits (142), Expect = 1e-08
Identities = 59/253 (23%), Positives = 101/253 (39%), Gaps = 44/253 (17%)
Query: 329 VNTMDDQGMTPLMYACAAGDEAMVQMLIDAGANLDIQVPSNSPRHPSIHPDSRHWTSLTF 388
V+++D +G T L A A G+ +V+ L+D G + + H D WT L
Sbjct: 807 VDSIDSEGRTVLSIASAQGNVEVVRTLLDRGLDEN-------------HRDDAGWTPLHM 853
Query: 389 AVLHGHISVVQLLLDAGAHVEGSAVNGGEDSYAETPLQLASAAGNYELVSLLLSRGADPL 448
A GH + + L++ GA D+ P LAS G+Y+ V +LL
Sbjct: 854 AAFEGHRLICEALIEQGARTNEI------DNDGRIPFILASQEGHYDCVQILLEN----- 902
Query: 449 LSMLEAHGMGSSLHEDMNCFSHSAAHGHRNVLRKLLTQPQQAKAD---------VLSLEE 499
S ++ G ++ N +A GHR+++ L + +L+LE
Sbjct: 903 KSNIDQRG-----YDGRNALRVAALEGHRDIVELLFSHGADVNCKDADGRPTLYILALEN 957
Query: 500 --ILAEGVEESDASSQGSGSEGPVRLS----RTRTKALQEAMYYSAEHGYVDITMELRAL 553
+AE E+ A+ + S +EG L + + +Q + Y A+ D
Sbjct: 958 QLTMAEYFLENGANVEASDAEGRTALHVSCWQGHMEMVQVLIAYHADVNAADNEKRSALQ 1017
Query: 554 GVPWKLHIWIESL 566
W+ H+ + L
Sbjct: 1018 SAAWQGHVKVVQL 1030
Score = 57.0 bits (136), Expect = 7e-08
Identities = 50/173 (28%), Positives = 74/173 (42%), Gaps = 31/173 (17%)
Query: 312 GRTDLINQAIEALGPDGVNTMDDQGMTPLMYACAAGDEAMVQMLIDAGANLDIQVPSNSP 371
G D++N + G D + D G TPL A G +V LI GAN++
Sbjct: 556 GSLDVVNLLVSR-GAD-LEIEDAHGHTPLTLAARQGHTKVVNCLIGCGANIN-------- 605
Query: 372 RHPSIHPDSRHWTSLTFAVLHGHISVVQLLLDAGAHVEGSAVNGGEDSYAETPLQLASAA 431
H D WT+L A GH VV LL AG V+ + D+ + T L+ A+
Sbjct: 606 -----HTDQDGWTALRSAAWGGHTEVVSALLYAGVKVDCA------DADSRTALRAAAWG 654
Query: 432 GNYELVSLLLSRGADPLLSMLEAHGMGSSLHEDMNCFSHSAAHGHRNVLRKLL 484
G+ ++V LL GA+ + + +E +A GHR ++ LL
Sbjct: 655 GHEDIVLNLLQHGAE----------VNKADNEGRTALIAAAYMGHREIVEHLL 697
Score = 54.3 bits (129), Expect = 5e-07
Identities = 40/119 (33%), Positives = 57/119 (47%), Gaps = 19/119 (15%)
Query: 329 VNTMDDQGMTPLMYACAAGDEAMVQMLIDAGANLDIQVPSNSPRHPSIHPDSRHWTSLTF 388
V D +G T L +C G MVQ+LI A D+ N R ++L
Sbjct: 972 VEASDAEGRTALHVSCWQGHMEMVQVLIAYHA--DVNAADNEKR-----------SALQS 1018
Query: 389 AVLHGHISVVQLLLDAGAHVEGSAVNGGEDSYAETPLQLASAAGNYELVSLLLSRGADP 447
A GH+ VVQLL++ GA V+ + G T L +A+ G+ ++V +LL GADP
Sbjct: 1019 AAWQGHVKVVQLLIEHGAVVDHTCNQGA------TALCIAAQEGHIDVVQVLLEHGADP 1071
Score = 35.8 bits (81), Expect = 0.17
Identities = 36/114 (31%), Positives = 53/114 (46%), Gaps = 37/114 (32%)
Query: 397 VVQLLLDAGAHV--------------------------EGSAVNGGEDSYAETPLQLASA 430
V+QLL+ AGAHV G++VN DS T L A+
Sbjct: 496 VLQLLVKAGAHVNSEDDRTSCIVRQALEREDSIRTLLDNGASVNQC-DSNGRTLLANAAY 554
Query: 431 AGNYELVSLLLSRGADPLLSMLEAHGMGSSLHEDMNCFSHSAAHGHRNVLRKLL 484
+G+ ++V+LL+SRGAD L + +AHG H + +A GH V+ L+
Sbjct: 555 SGSLDVVNLLVSRGAD--LEIEDAHG-----HTPLTL---AARQGHTKVVNCLI 598
Score = 33.1 bits (74), Expect = 1.1
Identities = 30/101 (29%), Positives = 46/101 (45%), Gaps = 21/101 (20%)
Query: 334 DQGMTPLMYACAAGDEAMVQMLIDAGANLDIQVPSNSPRHPSIHPDSRHWTSLTFAVLHG 393
+QG T L A G +VQ+L++ GA+ + H D T++ A +G
Sbjct: 1043 NQGATALCIAAQEGHIDVVQVLLEHGADPN-------------HADQFGRTAMRVAAKNG 1089
Query: 394 HISVVQLLLDAGAHVEGSAVNGGEDSYAET----PLQLASA 430
H +++LL GA S++NG S T PLQ S+
Sbjct: 1090 HSQIIKLLEKYGA----SSLNGCSPSPVHTMEQKPLQSLSS 1126
>gi|157739945 tetratricopeptide repeat, ankyrin repeat and coiled-coil
containing 2 [Homo sapiens]
Length = 1990
Score = 62.8 bits (151), Expect = 1e-09
Identities = 42/117 (35%), Positives = 59/117 (50%), Gaps = 19/117 (16%)
Query: 329 VNTMDDQGMTPLMYACAAGDEAMVQMLIDAGANLDIQVPSNSPRHPSIHPDSRHWTSLTF 388
VN D QG TPLM A + G V L+ GA++ + D T+L++
Sbjct: 1093 VNMADKQGRTPLMMAASEGHLGTVDFLLAQGASIALM-------------DKEGLTALSW 1139
Query: 389 AVLHGHISVVQLLLDAGAHVEGSAVNGGEDSYAETPLQLASAAGNYELVSLLLSRGA 445
A L GH+SVV+ L+D GA + + NG TPL LA+ G+ E+V L+ GA
Sbjct: 1140 ACLKGHLSVVRSLVDNGAATDHADKNG------RTPLDLAAFYGDAEVVQFLVDHGA 1190
Score = 53.1 bits (126), Expect = 1e-06
Identities = 38/114 (33%), Positives = 51/114 (44%), Gaps = 19/114 (16%)
Query: 332 MDDQGMTPLMYACAAGDEAMVQMLIDAGANLDIQVPSNSPRHPSIHPDSRHWTSLTFAVL 391
MD +G+T L +AC G ++V+ L+D GA D H D T L A
Sbjct: 1129 MDKEGLTALSWACLKGHLSVVRSLVDNGAATD-------------HADKNGRTPLDLAAF 1175
Query: 392 HGHISVVQLLLDAGAHVEGSAVNGGEDSYAETPLQLASAAGNYELVSLLLSRGA 445
+G VVQ L+D GA +E +G PL A N +V LL +GA
Sbjct: 1176 YGDAEVVQFLVDHGAMIEHVDYSG------MRPLDRAVGCRNTSVVVTLLKKGA 1223
Score = 45.4 bits (106), Expect = 2e-04
Identities = 35/114 (30%), Positives = 53/114 (46%), Gaps = 14/114 (12%)
Query: 329 VNTMDDQGMTPLMYACAAGDEAMVQMLIDAGANLDIQVPSNSPRHPSIHPDSRHWTSLTF 388
V+ + G+TPL YA AAG ++V +L A +D H D +L
Sbjct: 911 VDASSESGLTPLGYAAAAGYLSIVVLLCKKRAKVD-------------HLDKNGQCALVH 957
Query: 389 AVLHGHISVVQLLLDAGAHVEGSAVNGGEDSYAETPLQLASAAGNY-ELVSLLL 441
A L GH+ VV+ L+ + G + S+A +A+A+ Y E+VS LL
Sbjct: 958 AALRGHLEVVKFLIQCDWTMAGQQQGVFKKSHAIQQALIAAASMGYTEIVSYLL 1011
Score = 45.4 bits (106), Expect = 2e-04
Identities = 41/157 (26%), Positives = 68/157 (43%), Gaps = 30/157 (19%)
Query: 329 VNTMDDQ-GMTPLMYACAAGDEAMVQMLIDAGANLDIQVPSNSPRHPSIHPDSRHWTSLT 387
+N+ D G T L A G + ++L++ GA + P+ R L
Sbjct: 1026 INSFDSLWGETALTAAAGRGKLEVCRLLLEQGAAV-------------AQPNRRGAVPLF 1072
Query: 388 FAVLHGHISVVQLLLDAGAHVEGSAVNGGEDSYAETPLQLASAAGNYELVSLLLSRGADP 447
V GH +V LLL GA V + D TPL +A++ G+ V LL++GA
Sbjct: 1073 STVRQGHWQIVDLLLTHGADVNMA------DKQGRTPLMMAASEGHLGTVDFLLAQGAS- 1125
Query: 448 LLSMLEAHGMGSSLHEDMNCFSHSAAHGHRNVLRKLL 484
+++++ G + S + GH +V+R L+
Sbjct: 1126 -IALMDKEG--------LTALSWACLKGHLSVVRSLV 1153
Score = 36.6 bits (83), Expect = 0.100
Identities = 29/92 (31%), Positives = 48/92 (52%), Gaps = 16/92 (17%)
Query: 393 GHISVVQLLLDAGAHVEGSAVNGGEDSYAETPLQLASAAGNYELVSLLLSRGADPLLSML 452
G+ +V LLL+ GA+V+ S+ +G TPL A+AAG +V LL + A + L
Sbjct: 896 GYTEMVALLLEFGANVDASSESG------LTPLGYAAAAGYLSIVVLLCKKRAK--VDHL 947
Query: 453 EAHGMGSSLHEDMNCFSHSAAHGHRNVLRKLL 484
+ +G + + H+A GH V++ L+
Sbjct: 948 DKNGQCALV--------HAALRGHLEVVKFLI 971
Score = 32.0 bits (71), Expect = 2.5
Identities = 26/76 (34%), Positives = 32/76 (42%), Gaps = 13/76 (17%)
Query: 333 DDQGMTPLMYACAAGDEAMVQMLIDAGANLDIQVPSNSPRHPSIHPDSRHWTSLTFAVLH 392
D G TPL A GD +VQ L+D GA ++ H D L AV
Sbjct: 1163 DKNGRTPLDLAAFYGDAEVVQFLVDHGAMIE-------------HVDYSGMRPLDRAVGC 1209
Query: 393 GHISVVQLLLDAGAHV 408
+ SVV LL GA +
Sbjct: 1210 RNTSVVVTLLKKGAKI 1225
>gi|209571547 kelch repeat and BTB (POZ) domain containing 4 isoform
a [Homo sapiens]
Length = 534
Score = 62.4 bits (150), Expect = 2e-09
Identities = 35/153 (22%), Positives = 78/153 (50%), Gaps = 5/153 (3%)
Query: 653 LNNKEMSDVTFLVEGKLFYAHKVLLVTASNRFKTLMTNKSEQDGDSSKTIEISDMKYHIF 712
L + +DVT VEG+ F H+++L S F+++ T+ ++ ++ I + D+ +F
Sbjct: 55 LEEELFADVTISVEGREFQLHRLVLSAQSCFFRSMFTSNLKE--AHNRVIVLQDVSESVF 112
Query: 713 QMMMQYLYYGGTESMEIPTTDILELLSAASLFQLDALQRHCEILCSQTLSMESAVNTYKY 772
Q+++ Y+Y+G ++++ ++ E+ + ++QL +L C ++T+ + + +
Sbjct: 113 QLLVDYIYHG---TVKLRAEELQEIYEVSDMYQLTSLFEECSRFLARTVQVGNCLQVMWL 169
Query: 773 AKIHNAPELALFCEGFFLKHMKALLEQDAFRQL 805
A H+ PEL + H+ L + F L
Sbjct: 170 ADRHSDPELYTAAKHCAKTHLAQLQNTEEFLHL 202
>gi|209693446 kelch repeat and BTB (POZ) domain containing 4 isoform
b [Homo sapiens]
Length = 518
Score = 62.4 bits (150), Expect = 2e-09
Identities = 35/153 (22%), Positives = 78/153 (50%), Gaps = 5/153 (3%)
Query: 653 LNNKEMSDVTFLVEGKLFYAHKVLLVTASNRFKTLMTNKSEQDGDSSKTIEISDMKYHIF 712
L + +DVT VEG+ F H+++L S F+++ T+ ++ ++ I + D+ +F
Sbjct: 39 LEEELFADVTISVEGREFQLHRLVLSAQSCFFRSMFTSNLKE--AHNRVIVLQDVSESVF 96
Query: 713 QMMMQYLYYGGTESMEIPTTDILELLSAASLFQLDALQRHCEILCSQTLSMESAVNTYKY 772
Q+++ Y+Y+G ++++ ++ E+ + ++QL +L C ++T+ + + +
Sbjct: 97 QLLVDYIYHG---TVKLRAEELQEIYEVSDMYQLTSLFEECSRFLARTVQVGNCLQVMWL 153
Query: 773 AKIHNAPELALFCEGFFLKHMKALLEQDAFRQL 805
A H+ PEL + H+ L + F L
Sbjct: 154 ADRHSDPELYTAAKHCAKTHLAQLQNTEEFLHL 186
>gi|151108413 BTB (POZ) domain containing 9 isoform a [Homo sapiens]
Length = 612
Score = 62.0 bits (149), Expect = 2e-09
Identities = 41/154 (26%), Positives = 74/154 (48%), Gaps = 3/154 (1%)
Query: 653 LNNKEMSDVTFLVEGKLFYAHKVLLVTASNRFKTLMTNKSEQDGDSSKTIEISDMKYHIF 712
L +E DVTF+VE K F AH+V+L F+ L+ ++ I + D F
Sbjct: 30 LIGEEYGDVTFVVEKKRFPAHRVILAARCQYFRALLYG-GMRESQPEAEIPLQDTTAEAF 88
Query: 713 QMMMQYLYYGGTESMEIPTTDILELLSAASLFQLDALQ-RHCEILCSQTLSMESAVNTYK 771
M+++Y+Y G + +L+ LS A + L+ E LC+ L++++ T+
Sbjct: 89 TMLLKYIYTGRATLTDEKEEVLLDFLSLAHKYGFPELEDSTSEYLCT-ILNIQNVCMTFD 147
Query: 772 YAKIHNAPELALFCEGFFLKHMKALLEQDAFRQL 805
A +++ P+L C F ++ + +L + F L
Sbjct: 148 VASLYSLPKLTCMCCMFMDRNAQEVLSSEGFLSL 181
>gi|151108411 BTB (POZ) domain containing 9 isoform a [Homo sapiens]
Length = 612
Score = 62.0 bits (149), Expect = 2e-09
Identities = 41/154 (26%), Positives = 74/154 (48%), Gaps = 3/154 (1%)
Query: 653 LNNKEMSDVTFLVEGKLFYAHKVLLVTASNRFKTLMTNKSEQDGDSSKTIEISDMKYHIF 712
L +E DVTF+VE K F AH+V+L F+ L+ ++ I + D F
Sbjct: 30 LIGEEYGDVTFVVEKKRFPAHRVILAARCQYFRALLYG-GMRESQPEAEIPLQDTTAEAF 88
Query: 713 QMMMQYLYYGGTESMEIPTTDILELLSAASLFQLDALQ-RHCEILCSQTLSMESAVNTYK 771
M+++Y+Y G + +L+ LS A + L+ E LC+ L++++ T+
Sbjct: 89 TMLLKYIYTGRATLTDEKEEVLLDFLSLAHKYGFPELEDSTSEYLCT-ILNIQNVCMTFD 147
Query: 772 YAKIHNAPELALFCEGFFLKHMKALLEQDAFRQL 805
A +++ P+L C F ++ + +L + F L
Sbjct: 148 VASLYSLPKLTCMCCMFMDRNAQEVLSSEGFLSL 181
>gi|40018614 DRE1 protein [Homo sapiens]
Length = 600
Score = 62.0 bits (149), Expect = 2e-09
Identities = 37/154 (24%), Positives = 74/154 (48%), Gaps = 5/154 (3%)
Query: 652 FLNNKEMSDVTFLVEGKLFYAHKVLLVTASNRFKTLMTNKSEQDGDSSKTIEISDMKYHI 711
F +++ +DV VEGK F H+ +L S+ F+ + N + + +EI+ +
Sbjct: 59 FRDSRLFTDVIICVEGKEFPCHRAVLSACSSYFRAMFCNDHRESRE--MLVEINGILAEA 116
Query: 712 FQMMMQYLYYGGTESMEIPTTDILELLSAASLFQLDALQRHCEILCSQTLSMESAVNTYK 771
+ +QY+Y G ++I T ++ L +SLFQ+ L+ C + L + + +
Sbjct: 117 MECFLQYVYTG---KVKITTENVQYLFETSSLFQISVLRDACAKFLEEQLDPCNCLGIQR 173
Query: 772 YAKIHNAPELALFCEGFFLKHMKALLEQDAFRQL 805
+A H+ L C+ F L+ + + + + F +L
Sbjct: 174 FADTHSLKTLFTKCKNFALQTFEDVSQHEEFLEL 207
>gi|170784844 kelch-like 7 isoform 2 [Homo sapiens]
Length = 564
Score = 61.2 bits (147), Expect = 4e-09
Identities = 39/172 (22%), Positives = 80/172 (46%), Gaps = 5/172 (2%)
Query: 648 LDPHFLNNKEMSDVTFLVEGKLFYAHKVLLVTASNRFKTLMTNKSEQDGDSSKTIEISDM 707
L H K + DV +V+ + AH+V+L AS+ F + T + S +E+ D
Sbjct: 11 LTSHINLKKTLCDVILMVQERKIPAHRVVLAAASHFFNLMFTTNMLES--KSFEVELKDA 68
Query: 708 KYHIFQMMMQYLYYGGTESMEIPTTDILELLSAASLFQLDALQRHCEILCSQTLSMESAV 767
+ I + ++++ Y T + + + ++ LL AA+ +Q++ +++ C + + + +
Sbjct: 69 EPDIIEQLVEFAY---TARISVNSNNVQSLLDAANQYQIEPVKKMCVDFLKEQVDASNCL 125
Query: 768 NTYKYAKIHNAPELALFCEGFFLKHMKALLEQDAFRQLIYGRSSKVQGLDPL 819
A+ + PEL + F +H + + D F QL R + + D L
Sbjct: 126 GISVLAECLDCPELKATADDFIHQHFTEVYKTDEFLQLDVKRVTHLLNQDTL 177
>gi|40255071 kelch-like 23 [Homo sapiens]
Length = 558
Score = 61.2 bits (147), Expect = 4e-09
Identities = 34/139 (24%), Positives = 68/139 (48%), Gaps = 5/139 (3%)
Query: 667 GKLFYAHKVLLVTASNRFKTLMTNKSEQDGDSSKTIEISDMKYHIFQMMMQYLYYGGTES 726
G +F+ H+ +L SN FK + T ++ I++S + + I + ++ Y Y T
Sbjct: 45 GIIFHCHRAVLAACSNYFKAMFT--ADMKEKFKNKIKLSGIHHDILEGLVNYAY---TSQ 99
Query: 727 MEIPTTDILELLSAASLFQLDALQRHCEILCSQTLSMESAVNTYKYAKIHNAPELALFCE 786
+EI ++ LL AA L Q ++++ CE + L +++ + + +A+ H PEL
Sbjct: 100 IEITKRNVQSLLEAADLLQFLSVKKACERFLVRHLDIDNCIGMHSFAEFHVCPELEKESR 159
Query: 787 GFFLKHMKALLEQDAFRQL 805
K + +Q+ F ++
Sbjct: 160 RILCSKFKEVWQQEEFLEI 178
>gi|170784846 kelch-like 7 isoform 1 [Homo sapiens]
Length = 586
Score = 59.7 bits (143), Expect = 1e-08
Identities = 37/164 (22%), Positives = 78/164 (47%), Gaps = 5/164 (3%)
Query: 656 KEMSDVTFLVEGKLFYAHKVLLVTASNRFKTLMTNKSEQDGDSSKTIEISDMKYHIFQMM 715
K + DV +V+ + AH+V+L AS+ F + T + S +E+ D + I + +
Sbjct: 41 KTLCDVILMVQERKIPAHRVVLAAASHFFNLMFTTNMLES--KSFEVELKDAEPDIIEQL 98
Query: 716 MQYLYYGGTESMEIPTTDILELLSAASLFQLDALQRHCEILCSQTLSMESAVNTYKYAKI 775
+++ Y T + + + ++ LL AA+ +Q++ +++ C + + + + A+
Sbjct: 99 VEFAY---TARISVNSNNVQSLLDAANQYQIEPVKKMCVDFLKEQVDASNCLGISVLAEC 155
Query: 776 HNAPELALFCEGFFLKHMKALLEQDAFRQLIYGRSSKVQGLDPL 819
+ PEL + F +H + + D F QL R + + D L
Sbjct: 156 LDCPELKATADDFIHQHFTEVYKTDEFLQLDVKRVTHLLNQDTL 199
Database: hs.faa
Posted date: Aug 4, 2009 4:42 PM
Number of letters in database: 18,247,518
Number of sequences in database: 37,866
Lambda K H
0.319 0.133 0.391
Gapped
Lambda K H
0.267 0.0410 0.140
Matrix: BLOSUM62
Gap Penalties: Existence: 11, Extension: 1
Number of Hits to DB: 31,178,723
Number of Sequences: 37866
Number of extensions: 1390905
Number of successful extensions: 6664
Number of sequences better than 10.0: 30
Number of HSP's better than 10.0 without gapping: 192
Number of HSP's successfully gapped in prelim test: 252
Number of HSP's that attempted gapping in prelim test: 4600
Number of HSP's gapped (non-prelim): 1240
length of query: 839
length of database: 18,247,518
effective HSP length: 111
effective length of query: 728
effective length of database: 14,044,392
effective search space: 10224317376
effective search space used: 10224317376
T: 11
A: 40
X1: 16 ( 7.4 bits)
X2: 38 (14.6 bits)
X3: 64 (24.7 bits)
S1: 41 (21.8 bits)
S2: 66 (30.0 bits)
Search results were obtained with NCBI BLAST and RefSeq entries.
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Guide to the Human Genome
Copyright © 2010 by Stewart Scherer. All rights reserved.