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Search of human proteins with 21955172
BLASTP 2.2.11 [Jun-05-2005]
Reference: Altschul, Stephen F., Thomas L. Madden, Alejandro A. Schaffer,
Jinghui Zhang, Zheng Zhang, Webb Miller, and David J. Lipman (1997),
"Gapped BLAST and PSI-BLAST: a new generation of protein database search
programs", Nucleic Acids Res. 25:3389-3402.
Query= gi|21955172 pleckstrin homology-like domain, family B, member 2
isoform c [Homo sapiens]
(1210 letters)
Database: hs.faa
37,866 sequences; 18,247,518 total letters
Searching..................................................done
Score E
Sequences producing significant alignments: (bits) Value
gi|197313728 pleckstrin homology-like domain, family B, member 2... 2385 0.0
gi|21955172 pleckstrin homology-like domain, family B, member 2 ... 2385 0.0
gi|197313732 pleckstrin homology-like domain, family B, member 2... 2364 0.0
gi|197313730 pleckstrin homology-like domain, family B, member 2... 2364 0.0
gi|221219026 pleckstrin homology-like domain, family B, member 1... 657 0.0
gi|221219024 pleckstrin homology-like domain, family B, member 1... 652 0.0
gi|38424073 pleckstrin homology-like domain, family B, member 1 ... 652 0.0
gi|157266264 pleckstrin homology-like domain, family B, member 3... 201 5e-51
gi|55770888 early endosome antigen 1, 162kD [Homo sapiens] 67 8e-11
gi|41406064 myosin, heavy polypeptide 10, non-muscle [Homo sapiens] 65 5e-10
gi|6715600 golgi autoantigen, golgin subfamily a, 4 [Homo sapiens] 62 3e-09
gi|41281453 serine/threonine kinase 2 [Homo sapiens] 60 1e-08
gi|29788755 SET binding factor 2 [Homo sapiens] 59 2e-08
gi|239735519 SET binding factor 1 [Homo sapiens] 58 6e-08
gi|22538387 A-kinase anchor protein 9 isoform 2 [Homo sapiens] 57 8e-08
gi|4885583 Rho-associated, coiled-coil containing protein kinase... 57 1e-07
gi|38044112 restin isoform b [Homo sapiens] 56 2e-07
gi|4506751 restin isoform a [Homo sapiens] 56 2e-07
gi|21735548 centrosomal protein 2 [Homo sapiens] 56 2e-07
gi|114155142 nuclear pore complex-associated protein TPR [Homo s... 56 2e-07
gi|110624781 myosin, heavy polypeptide 13, skeletal muscle [Homo... 55 3e-07
gi|118498356 kinectin 1 isoform a [Homo sapiens] 55 4e-07
gi|33620775 kinectin 1 isoform a [Homo sapiens] 55 4e-07
gi|41322923 plectin 1 isoform 11 [Homo sapiens] 54 7e-07
gi|41322914 plectin 1 isoform 10 [Homo sapiens] 54 7e-07
gi|41322919 plectin 1 isoform 8 [Homo sapiens] 54 7e-07
gi|41322910 plectin 1 isoform 7 [Homo sapiens] 54 7e-07
gi|41322916 plectin 1 isoform 6 [Homo sapiens] 54 7e-07
gi|41322908 plectin 1 isoform 3 [Homo sapiens] 54 7e-07
gi|41322912 plectin 1 isoform 2 [Homo sapiens] 54 7e-07
>gi|197313728 pleckstrin homology-like domain, family B, member 2
isoform b [Homo sapiens]
Length = 1237
Score = 2385 bits (6180), Expect = 0.0
Identities = 1210/1210 (100%), Positives = 1210/1210 (100%)
Query: 1 MEEHSYIQKELDLQNGSLEEDSVVHSVENDSQNMMESLSPKKYSSSLRFKANGDYSGSYL 60
MEEHSYIQKELDLQNGSLEEDSVVHSVENDSQNMMESLSPKKYSSSLRFKANGDYSGSYL
Sbjct: 28 MEEHSYIQKELDLQNGSLEEDSVVHSVENDSQNMMESLSPKKYSSSLRFKANGDYSGSYL 87
Query: 61 TLSQPVPAKRSPSPLGTSVRSSPSLAKIQGSKQFSYDGTDKNIPMKPPTPLLNTTSSLSG 120
TLSQPVPAKRSPSPLGTSVRSSPSLAKIQGSKQFSYDGTDKNIPMKPPTPLLNTTSSLSG
Sbjct: 88 TLSQPVPAKRSPSPLGTSVRSSPSLAKIQGSKQFSYDGTDKNIPMKPPTPLLNTTSSLSG 147
Query: 121 YPLGRADFDHYTGRDSERALRLSEKPPYSKYSSRHKSHDNVYSLGGLEGRKASGSLLAMW 180
YPLGRADFDHYTGRDSERALRLSEKPPYSKYSSRHKSHDNVYSLGGLEGRKASGSLLAMW
Sbjct: 148 YPLGRADFDHYTGRDSERALRLSEKPPYSKYSSRHKSHDNVYSLGGLEGRKASGSLLAMW 207
Query: 181 NGSSLSDAGPPPISRSGAASMPSSPKQARKMSIQDSLALQPKLTRHKELASENINLRTRK 240
NGSSLSDAGPPPISRSGAASMPSSPKQARKMSIQDSLALQPKLTRHKELASENINLRTRK
Sbjct: 208 NGSSLSDAGPPPISRSGAASMPSSPKQARKMSIQDSLALQPKLTRHKELASENINLRTRK 267
Query: 241 YSSSSLSHMGAYSRSLPRLYRATENQLTPLSLPPRNSLGNSKRTKLGEKDLPHSVIDNDN 300
YSSSSLSHMGAYSRSLPRLYRATENQLTPLSLPPRNSLGNSKRTKLGEKDLPHSVIDNDN
Sbjct: 268 YSSSSLSHMGAYSRSLPRLYRATENQLTPLSLPPRNSLGNSKRTKLGEKDLPHSVIDNDN 327
Query: 301 YLNFSSLSSGALPYKTSASEGNPYVSSTLSVPASPRVARKMLLASTSSCASDDFDQASYV 360
YLNFSSLSSGALPYKTSASEGNPYVSSTLSVPASPRVARKMLLASTSSCASDDFDQASYV
Sbjct: 328 YLNFSSLSSGALPYKTSASEGNPYVSSTLSVPASPRVARKMLLASTSSCASDDFDQASYV 387
Query: 361 GTNPSHSLLAGESDRVFATRRNFSCGSVEFDEADLESLRQASGTPQPALRERKSSISSIS 420
GTNPSHSLLAGESDRVFATRRNFSCGSVEFDEADLESLRQASGTPQPALRERKSSISSIS
Sbjct: 388 GTNPSHSLLAGESDRVFATRRNFSCGSVEFDEADLESLRQASGTPQPALRERKSSISSIS 447
Query: 421 GRDDLMDYHRRQREERLREQEMERLERQRLETILSLCAEYTKPDSRLSTGTTVEDVQKIN 480
GRDDLMDYHRRQREERLREQEMERLERQRLETILSLCAEYTKPDSRLSTGTTVEDVQKIN
Sbjct: 448 GRDDLMDYHRRQREERLREQEMERLERQRLETILSLCAEYTKPDSRLSTGTTVEDVQKIN 507
Query: 481 KELEKLQLSDEESVFEEALMSPDTRYRCHRKDSLPDADLASCGSLSQSSASFFTPRSTRN 540
KELEKLQLSDEESVFEEALMSPDTRYRCHRKDSLPDADLASCGSLSQSSASFFTPRSTRN
Sbjct: 508 KELEKLQLSDEESVFEEALMSPDTRYRCHRKDSLPDADLASCGSLSQSSASFFTPRSTRN 567
Query: 541 DELLSDLTRTPPPPSSTFPKASSESSYLSILPKTPEGISEEQRSQELAAMEETRIVILNN 600
DELLSDLTRTPPPPSSTFPKASSESSYLSILPKTPEGISEEQRSQELAAMEETRIVILNN
Sbjct: 568 DELLSDLTRTPPPPSSTFPKASSESSYLSILPKTPEGISEEQRSQELAAMEETRIVILNN 627
Query: 601 LEELKQKIKDINDQMDESFRELDMECALLDGEQKSETTELMKEKEILDHLNRKIAELEKN 660
LEELKQKIKDINDQMDESFRELDMECALLDGEQKSETTELMKEKEILDHLNRKIAELEKN
Sbjct: 628 LEELKQKIKDINDQMDESFRELDMECALLDGEQKSETTELMKEKEILDHLNRKIAELEKN 687
Query: 661 IVGEKTKDADLLDVESKHFEDLEFQQLEHESRLDEEKENLTQQLLREVAEYQRNIVSRKE 720
IVGEKTKDADLLDVESKHFEDLEFQQLEHESRLDEEKENLTQQLLREVAEYQRNIVSRKE
Sbjct: 688 IVGEKTKDADLLDVESKHFEDLEFQQLEHESRLDEEKENLTQQLLREVAEYQRNIVSRKE 747
Query: 721 KISALKKQANHIVQQAQREQDHFVKEKNNLIMMLQREKENLCNLEKKYSSLSGGKGFPVN 780
KISALKKQANHIVQQAQREQDHFVKEKNNLIMMLQREKENLCNLEKKYSSLSGGKGFPVN
Sbjct: 748 KISALKKQANHIVQQAQREQDHFVKEKNNLIMMLQREKENLCNLEKKYSSLSGGKGFPVN 807
Query: 781 PNTLKEGYISVNEINEPCGNSTNLSPSTQFPADADAVATEPATAVLASQPQSKEHFRSLE 840
PNTLKEGYISVNEINEPCGNSTNLSPSTQFPADADAVATEPATAVLASQPQSKEHFRSLE
Sbjct: 808 PNTLKEGYISVNEINEPCGNSTNLSPSTQFPADADAVATEPATAVLASQPQSKEHFRSLE 867
Query: 841 ERKKQHKEGLYLSDTLPRKKTTSSISPHFSSATMGRSITPKAHLPLGQSNSCGSVLPPSL 900
ERKKQHKEGLYLSDTLPRKKTTSSISPHFSSATMGRSITPKAHLPLGQSNSCGSVLPPSL
Sbjct: 868 ERKKQHKEGLYLSDTLPRKKTTSSISPHFSSATMGRSITPKAHLPLGQSNSCGSVLPPSL 927
Query: 901 AAMAKDSESRRMLRGYNHQQMSEGHRQKSEFYNRTASESNVYLNSFHYPDHSYKDQAFDT 960
AAMAKDSESRRMLRGYNHQQMSEGHRQKSEFYNRTASESNVYLNSFHYPDHSYKDQAFDT
Sbjct: 928 AAMAKDSESRRMLRGYNHQQMSEGHRQKSEFYNRTASESNVYLNSFHYPDHSYKDQAFDT 987
Query: 961 LSLDSSDSMETSISACSPDNISSASTSNIARIEEMERLLKQAHAEKTRLLESREREMEAK 1020
LSLDSSDSMETSISACSPDNISSASTSNIARIEEMERLLKQAHAEKTRLLESREREMEAK
Sbjct: 988 LSLDSSDSMETSISACSPDNISSASTSNIARIEEMERLLKQAHAEKTRLLESREREMEAK 1047
Query: 1021 KRALEEEKRRREILEKRLQEETSQRQKLIEKEVKIRERQRAQARPLTRYLPVRKEDFDLR 1080
KRALEEEKRRREILEKRLQEETSQRQKLIEKEVKIRERQRAQARPLTRYLPVRKEDFDLR
Sbjct: 1048 KRALEEEKRRREILEKRLQEETSQRQKLIEKEVKIRERQRAQARPLTRYLPVRKEDFDLR 1107
Query: 1081 SHVETAGHNIDTCYHVSITEKTCRGFLIKMGGKIKTWKKRWFVFDRNKRTFSYYADKHET 1140
SHVETAGHNIDTCYHVSITEKTCRGFLIKMGGKIKTWKKRWFVFDRNKRTFSYYADKHET
Sbjct: 1108 SHVETAGHNIDTCYHVSITEKTCRGFLIKMGGKIKTWKKRWFVFDRNKRTFSYYADKHET 1167
Query: 1141 KLKGVIYFQAIEEVYYDHLKNANKSPNPLLTFSVKTHDRIYYMVAPSPEAMRIWMDVIVT 1200
KLKGVIYFQAIEEVYYDHLKNANKSPNPLLTFSVKTHDRIYYMVAPSPEAMRIWMDVIVT
Sbjct: 1168 KLKGVIYFQAIEEVYYDHLKNANKSPNPLLTFSVKTHDRIYYMVAPSPEAMRIWMDVIVT 1227
Query: 1201 GAEGYTHFLL 1210
GAEGYTHFLL
Sbjct: 1228 GAEGYTHFLL 1237
>gi|21955172 pleckstrin homology-like domain, family B, member 2
isoform c [Homo sapiens]
Length = 1210
Score = 2385 bits (6180), Expect = 0.0
Identities = 1210/1210 (100%), Positives = 1210/1210 (100%)
Query: 1 MEEHSYIQKELDLQNGSLEEDSVVHSVENDSQNMMESLSPKKYSSSLRFKANGDYSGSYL 60
MEEHSYIQKELDLQNGSLEEDSVVHSVENDSQNMMESLSPKKYSSSLRFKANGDYSGSYL
Sbjct: 1 MEEHSYIQKELDLQNGSLEEDSVVHSVENDSQNMMESLSPKKYSSSLRFKANGDYSGSYL 60
Query: 61 TLSQPVPAKRSPSPLGTSVRSSPSLAKIQGSKQFSYDGTDKNIPMKPPTPLLNTTSSLSG 120
TLSQPVPAKRSPSPLGTSVRSSPSLAKIQGSKQFSYDGTDKNIPMKPPTPLLNTTSSLSG
Sbjct: 61 TLSQPVPAKRSPSPLGTSVRSSPSLAKIQGSKQFSYDGTDKNIPMKPPTPLLNTTSSLSG 120
Query: 121 YPLGRADFDHYTGRDSERALRLSEKPPYSKYSSRHKSHDNVYSLGGLEGRKASGSLLAMW 180
YPLGRADFDHYTGRDSERALRLSEKPPYSKYSSRHKSHDNVYSLGGLEGRKASGSLLAMW
Sbjct: 121 YPLGRADFDHYTGRDSERALRLSEKPPYSKYSSRHKSHDNVYSLGGLEGRKASGSLLAMW 180
Query: 181 NGSSLSDAGPPPISRSGAASMPSSPKQARKMSIQDSLALQPKLTRHKELASENINLRTRK 240
NGSSLSDAGPPPISRSGAASMPSSPKQARKMSIQDSLALQPKLTRHKELASENINLRTRK
Sbjct: 181 NGSSLSDAGPPPISRSGAASMPSSPKQARKMSIQDSLALQPKLTRHKELASENINLRTRK 240
Query: 241 YSSSSLSHMGAYSRSLPRLYRATENQLTPLSLPPRNSLGNSKRTKLGEKDLPHSVIDNDN 300
YSSSSLSHMGAYSRSLPRLYRATENQLTPLSLPPRNSLGNSKRTKLGEKDLPHSVIDNDN
Sbjct: 241 YSSSSLSHMGAYSRSLPRLYRATENQLTPLSLPPRNSLGNSKRTKLGEKDLPHSVIDNDN 300
Query: 301 YLNFSSLSSGALPYKTSASEGNPYVSSTLSVPASPRVARKMLLASTSSCASDDFDQASYV 360
YLNFSSLSSGALPYKTSASEGNPYVSSTLSVPASPRVARKMLLASTSSCASDDFDQASYV
Sbjct: 301 YLNFSSLSSGALPYKTSASEGNPYVSSTLSVPASPRVARKMLLASTSSCASDDFDQASYV 360
Query: 361 GTNPSHSLLAGESDRVFATRRNFSCGSVEFDEADLESLRQASGTPQPALRERKSSISSIS 420
GTNPSHSLLAGESDRVFATRRNFSCGSVEFDEADLESLRQASGTPQPALRERKSSISSIS
Sbjct: 361 GTNPSHSLLAGESDRVFATRRNFSCGSVEFDEADLESLRQASGTPQPALRERKSSISSIS 420
Query: 421 GRDDLMDYHRRQREERLREQEMERLERQRLETILSLCAEYTKPDSRLSTGTTVEDVQKIN 480
GRDDLMDYHRRQREERLREQEMERLERQRLETILSLCAEYTKPDSRLSTGTTVEDVQKIN
Sbjct: 421 GRDDLMDYHRRQREERLREQEMERLERQRLETILSLCAEYTKPDSRLSTGTTVEDVQKIN 480
Query: 481 KELEKLQLSDEESVFEEALMSPDTRYRCHRKDSLPDADLASCGSLSQSSASFFTPRSTRN 540
KELEKLQLSDEESVFEEALMSPDTRYRCHRKDSLPDADLASCGSLSQSSASFFTPRSTRN
Sbjct: 481 KELEKLQLSDEESVFEEALMSPDTRYRCHRKDSLPDADLASCGSLSQSSASFFTPRSTRN 540
Query: 541 DELLSDLTRTPPPPSSTFPKASSESSYLSILPKTPEGISEEQRSQELAAMEETRIVILNN 600
DELLSDLTRTPPPPSSTFPKASSESSYLSILPKTPEGISEEQRSQELAAMEETRIVILNN
Sbjct: 541 DELLSDLTRTPPPPSSTFPKASSESSYLSILPKTPEGISEEQRSQELAAMEETRIVILNN 600
Query: 601 LEELKQKIKDINDQMDESFRELDMECALLDGEQKSETTELMKEKEILDHLNRKIAELEKN 660
LEELKQKIKDINDQMDESFRELDMECALLDGEQKSETTELMKEKEILDHLNRKIAELEKN
Sbjct: 601 LEELKQKIKDINDQMDESFRELDMECALLDGEQKSETTELMKEKEILDHLNRKIAELEKN 660
Query: 661 IVGEKTKDADLLDVESKHFEDLEFQQLEHESRLDEEKENLTQQLLREVAEYQRNIVSRKE 720
IVGEKTKDADLLDVESKHFEDLEFQQLEHESRLDEEKENLTQQLLREVAEYQRNIVSRKE
Sbjct: 661 IVGEKTKDADLLDVESKHFEDLEFQQLEHESRLDEEKENLTQQLLREVAEYQRNIVSRKE 720
Query: 721 KISALKKQANHIVQQAQREQDHFVKEKNNLIMMLQREKENLCNLEKKYSSLSGGKGFPVN 780
KISALKKQANHIVQQAQREQDHFVKEKNNLIMMLQREKENLCNLEKKYSSLSGGKGFPVN
Sbjct: 721 KISALKKQANHIVQQAQREQDHFVKEKNNLIMMLQREKENLCNLEKKYSSLSGGKGFPVN 780
Query: 781 PNTLKEGYISVNEINEPCGNSTNLSPSTQFPADADAVATEPATAVLASQPQSKEHFRSLE 840
PNTLKEGYISVNEINEPCGNSTNLSPSTQFPADADAVATEPATAVLASQPQSKEHFRSLE
Sbjct: 781 PNTLKEGYISVNEINEPCGNSTNLSPSTQFPADADAVATEPATAVLASQPQSKEHFRSLE 840
Query: 841 ERKKQHKEGLYLSDTLPRKKTTSSISPHFSSATMGRSITPKAHLPLGQSNSCGSVLPPSL 900
ERKKQHKEGLYLSDTLPRKKTTSSISPHFSSATMGRSITPKAHLPLGQSNSCGSVLPPSL
Sbjct: 841 ERKKQHKEGLYLSDTLPRKKTTSSISPHFSSATMGRSITPKAHLPLGQSNSCGSVLPPSL 900
Query: 901 AAMAKDSESRRMLRGYNHQQMSEGHRQKSEFYNRTASESNVYLNSFHYPDHSYKDQAFDT 960
AAMAKDSESRRMLRGYNHQQMSEGHRQKSEFYNRTASESNVYLNSFHYPDHSYKDQAFDT
Sbjct: 901 AAMAKDSESRRMLRGYNHQQMSEGHRQKSEFYNRTASESNVYLNSFHYPDHSYKDQAFDT 960
Query: 961 LSLDSSDSMETSISACSPDNISSASTSNIARIEEMERLLKQAHAEKTRLLESREREMEAK 1020
LSLDSSDSMETSISACSPDNISSASTSNIARIEEMERLLKQAHAEKTRLLESREREMEAK
Sbjct: 961 LSLDSSDSMETSISACSPDNISSASTSNIARIEEMERLLKQAHAEKTRLLESREREMEAK 1020
Query: 1021 KRALEEEKRRREILEKRLQEETSQRQKLIEKEVKIRERQRAQARPLTRYLPVRKEDFDLR 1080
KRALEEEKRRREILEKRLQEETSQRQKLIEKEVKIRERQRAQARPLTRYLPVRKEDFDLR
Sbjct: 1021 KRALEEEKRRREILEKRLQEETSQRQKLIEKEVKIRERQRAQARPLTRYLPVRKEDFDLR 1080
Query: 1081 SHVETAGHNIDTCYHVSITEKTCRGFLIKMGGKIKTWKKRWFVFDRNKRTFSYYADKHET 1140
SHVETAGHNIDTCYHVSITEKTCRGFLIKMGGKIKTWKKRWFVFDRNKRTFSYYADKHET
Sbjct: 1081 SHVETAGHNIDTCYHVSITEKTCRGFLIKMGGKIKTWKKRWFVFDRNKRTFSYYADKHET 1140
Query: 1141 KLKGVIYFQAIEEVYYDHLKNANKSPNPLLTFSVKTHDRIYYMVAPSPEAMRIWMDVIVT 1200
KLKGVIYFQAIEEVYYDHLKNANKSPNPLLTFSVKTHDRIYYMVAPSPEAMRIWMDVIVT
Sbjct: 1141 KLKGVIYFQAIEEVYYDHLKNANKSPNPLLTFSVKTHDRIYYMVAPSPEAMRIWMDVIVT 1200
Query: 1201 GAEGYTHFLL 1210
GAEGYTHFLL
Sbjct: 1201 GAEGYTHFLL 1210
>gi|197313732 pleckstrin homology-like domain, family B, member 2
isoform a [Homo sapiens]
Length = 1253
Score = 2364 bits (6126), Expect = 0.0
Identities = 1210/1253 (96%), Positives = 1210/1253 (96%), Gaps = 43/1253 (3%)
Query: 1 MEEHSYIQKELDLQNGSLEEDSVVHSVENDSQNMMESLSPKKYSSSLRFKANGDYSGSYL 60
MEEHSYIQKELDLQNGSLEEDSVVHSVENDSQNMMESLSPKKYSSSLRFKANGDYSGSYL
Sbjct: 1 MEEHSYIQKELDLQNGSLEEDSVVHSVENDSQNMMESLSPKKYSSSLRFKANGDYSGSYL 60
Query: 61 TLSQPVPAKRSPSPLGTSVRSSPSLAKIQGSKQFSYDGTDKNIPMKPPTPLLNTTSSLSG 120
TLSQPVPAKRSPSPLGTSVRSSPSLAKIQGSKQFSYDGTDKNIPMKPPTPLLNTTSSLSG
Sbjct: 61 TLSQPVPAKRSPSPLGTSVRSSPSLAKIQGSKQFSYDGTDKNIPMKPPTPLLNTTSSLSG 120
Query: 121 YPLGRADFDHYTGRDSERALRLSEKPPYSKYSSRHKSHDNVYSLGGLEGRKASGSLLAMW 180
YPLGRADFDHYTGRDSERALRLSEKPPYSKYSSRHKSHDNVYSLGGLEGRKASGSLLAMW
Sbjct: 121 YPLGRADFDHYTGRDSERALRLSEKPPYSKYSSRHKSHDNVYSLGGLEGRKASGSLLAMW 180
Query: 181 NGSSLSDAGPPPISRSGAASMPSSPKQARKMSIQDSLALQPKLTRHKELASENINLRTRK 240
NGSSLSDAGPPPISRSGAASMPSSPKQARKMSIQDSLALQPKLTRHKELASENINLRTRK
Sbjct: 181 NGSSLSDAGPPPISRSGAASMPSSPKQARKMSIQDSLALQPKLTRHKELASENINLRTRK 240
Query: 241 YSSSSLSHMGAYSRSLPRLYRATENQLTPLSLPPRNSLGNSKRTKLGEKDLPHSVIDNDN 300
YSSSSLSHMGAYSRSLPRLYRATENQLTPLSLPPRNSLGNSKRTKLGEKDLPHSVIDNDN
Sbjct: 241 YSSSSLSHMGAYSRSLPRLYRATENQLTPLSLPPRNSLGNSKRTKLGEKDLPHSVIDNDN 300
Query: 301 YLNFSSLSSGALPYKTSASEGNPYVSSTLSVPASPRVARKMLLASTSSCASDDFDQASYV 360
YLNFSSLSSGALPYKTSASEGNPYVSSTLSVPASPRVARKMLLASTSSCASDDFDQASYV
Sbjct: 301 YLNFSSLSSGALPYKTSASEGNPYVSSTLSVPASPRVARKMLLASTSSCASDDFDQASYV 360
Query: 361 GTNPSHSLLAGESDRVFATRRNFSCGSVEFDEADLESLRQASGTPQPALRERKSSISSIS 420
GTNPSHSLLAGESDRVFATRRNFSCGSVEFDEADLESLRQASGTPQPALRERKSSISSIS
Sbjct: 361 GTNPSHSLLAGESDRVFATRRNFSCGSVEFDEADLESLRQASGTPQPALRERKSSISSIS 420
Query: 421 GRDDLMDYHRRQREERLREQEMERLERQRLETILSLCAEYTKPDSRLSTGTTVEDVQKIN 480
GRDDLMDYHRRQREERLREQEMERLERQRLETILSLCAEYTKPDSRLSTGTTVEDVQKIN
Sbjct: 421 GRDDLMDYHRRQREERLREQEMERLERQRLETILSLCAEYTKPDSRLSTGTTVEDVQKIN 480
Query: 481 KELEKLQLSDEESVFEEALMSPDTRYRCHRKDSLPDADLASCGSLSQSSASFFTPRSTRN 540
KELEKLQLSDEESVFEEALMSPDTRYRCHRKDSLPDADLASCGSLSQSSASFFTPRSTRN
Sbjct: 481 KELEKLQLSDEESVFEEALMSPDTRYRCHRKDSLPDADLASCGSLSQSSASFFTPRSTRN 540
Query: 541 DELLSDLTRTPPPPSSTFPKASSESSYLSILPKTPEGISEEQRSQELAAMEETRIVILNN 600
DELLSDLTRTPPPPSSTFPKASSESSYLSILPKTPEGISEEQRSQELAAMEETRIVILNN
Sbjct: 541 DELLSDLTRTPPPPSSTFPKASSESSYLSILPKTPEGISEEQRSQELAAMEETRIVILNN 600
Query: 601 LEELKQKIKDINDQMDESFRELDMECALLDGEQKSETTELMKEKEILDHLNRKIAELEKN 660
LEELKQKIKDINDQMDESFRELDMECALLDGEQKSETTELMKEKEILDHLNRKIAELEKN
Sbjct: 601 LEELKQKIKDINDQMDESFRELDMECALLDGEQKSETTELMKEKEILDHLNRKIAELEKN 660
Query: 661 IVGEKTK-------------------------------------------DADLLDVESK 677
IVGEKTK DADLLDVESK
Sbjct: 661 IVGEKTKEKVKLDAEREKLERLQELYSEQKTQLDNCPESMREQLQQQLKRDADLLDVESK 720
Query: 678 HFEDLEFQQLEHESRLDEEKENLTQQLLREVAEYQRNIVSRKEKISALKKQANHIVQQAQ 737
HFEDLEFQQLEHESRLDEEKENLTQQLLREVAEYQRNIVSRKEKISALKKQANHIVQQAQ
Sbjct: 721 HFEDLEFQQLEHESRLDEEKENLTQQLLREVAEYQRNIVSRKEKISALKKQANHIVQQAQ 780
Query: 738 REQDHFVKEKNNLIMMLQREKENLCNLEKKYSSLSGGKGFPVNPNTLKEGYISVNEINEP 797
REQDHFVKEKNNLIMMLQREKENLCNLEKKYSSLSGGKGFPVNPNTLKEGYISVNEINEP
Sbjct: 781 REQDHFVKEKNNLIMMLQREKENLCNLEKKYSSLSGGKGFPVNPNTLKEGYISVNEINEP 840
Query: 798 CGNSTNLSPSTQFPADADAVATEPATAVLASQPQSKEHFRSLEERKKQHKEGLYLSDTLP 857
CGNSTNLSPSTQFPADADAVATEPATAVLASQPQSKEHFRSLEERKKQHKEGLYLSDTLP
Sbjct: 841 CGNSTNLSPSTQFPADADAVATEPATAVLASQPQSKEHFRSLEERKKQHKEGLYLSDTLP 900
Query: 858 RKKTTSSISPHFSSATMGRSITPKAHLPLGQSNSCGSVLPPSLAAMAKDSESRRMLRGYN 917
RKKTTSSISPHFSSATMGRSITPKAHLPLGQSNSCGSVLPPSLAAMAKDSESRRMLRGYN
Sbjct: 901 RKKTTSSISPHFSSATMGRSITPKAHLPLGQSNSCGSVLPPSLAAMAKDSESRRMLRGYN 960
Query: 918 HQQMSEGHRQKSEFYNRTASESNVYLNSFHYPDHSYKDQAFDTLSLDSSDSMETSISACS 977
HQQMSEGHRQKSEFYNRTASESNVYLNSFHYPDHSYKDQAFDTLSLDSSDSMETSISACS
Sbjct: 961 HQQMSEGHRQKSEFYNRTASESNVYLNSFHYPDHSYKDQAFDTLSLDSSDSMETSISACS 1020
Query: 978 PDNISSASTSNIARIEEMERLLKQAHAEKTRLLESREREMEAKKRALEEEKRRREILEKR 1037
PDNISSASTSNIARIEEMERLLKQAHAEKTRLLESREREMEAKKRALEEEKRRREILEKR
Sbjct: 1021 PDNISSASTSNIARIEEMERLLKQAHAEKTRLLESREREMEAKKRALEEEKRRREILEKR 1080
Query: 1038 LQEETSQRQKLIEKEVKIRERQRAQARPLTRYLPVRKEDFDLRSHVETAGHNIDTCYHVS 1097
LQEETSQRQKLIEKEVKIRERQRAQARPLTRYLPVRKEDFDLRSHVETAGHNIDTCYHVS
Sbjct: 1081 LQEETSQRQKLIEKEVKIRERQRAQARPLTRYLPVRKEDFDLRSHVETAGHNIDTCYHVS 1140
Query: 1098 ITEKTCRGFLIKMGGKIKTWKKRWFVFDRNKRTFSYYADKHETKLKGVIYFQAIEEVYYD 1157
ITEKTCRGFLIKMGGKIKTWKKRWFVFDRNKRTFSYYADKHETKLKGVIYFQAIEEVYYD
Sbjct: 1141 ITEKTCRGFLIKMGGKIKTWKKRWFVFDRNKRTFSYYADKHETKLKGVIYFQAIEEVYYD 1200
Query: 1158 HLKNANKSPNPLLTFSVKTHDRIYYMVAPSPEAMRIWMDVIVTGAEGYTHFLL 1210
HLKNANKSPNPLLTFSVKTHDRIYYMVAPSPEAMRIWMDVIVTGAEGYTHFLL
Sbjct: 1201 HLKNANKSPNPLLTFSVKTHDRIYYMVAPSPEAMRIWMDVIVTGAEGYTHFLL 1253
>gi|197313730 pleckstrin homology-like domain, family B, member 2
isoform a [Homo sapiens]
Length = 1253
Score = 2364 bits (6126), Expect = 0.0
Identities = 1210/1253 (96%), Positives = 1210/1253 (96%), Gaps = 43/1253 (3%)
Query: 1 MEEHSYIQKELDLQNGSLEEDSVVHSVENDSQNMMESLSPKKYSSSLRFKANGDYSGSYL 60
MEEHSYIQKELDLQNGSLEEDSVVHSVENDSQNMMESLSPKKYSSSLRFKANGDYSGSYL
Sbjct: 1 MEEHSYIQKELDLQNGSLEEDSVVHSVENDSQNMMESLSPKKYSSSLRFKANGDYSGSYL 60
Query: 61 TLSQPVPAKRSPSPLGTSVRSSPSLAKIQGSKQFSYDGTDKNIPMKPPTPLLNTTSSLSG 120
TLSQPVPAKRSPSPLGTSVRSSPSLAKIQGSKQFSYDGTDKNIPMKPPTPLLNTTSSLSG
Sbjct: 61 TLSQPVPAKRSPSPLGTSVRSSPSLAKIQGSKQFSYDGTDKNIPMKPPTPLLNTTSSLSG 120
Query: 121 YPLGRADFDHYTGRDSERALRLSEKPPYSKYSSRHKSHDNVYSLGGLEGRKASGSLLAMW 180
YPLGRADFDHYTGRDSERALRLSEKPPYSKYSSRHKSHDNVYSLGGLEGRKASGSLLAMW
Sbjct: 121 YPLGRADFDHYTGRDSERALRLSEKPPYSKYSSRHKSHDNVYSLGGLEGRKASGSLLAMW 180
Query: 181 NGSSLSDAGPPPISRSGAASMPSSPKQARKMSIQDSLALQPKLTRHKELASENINLRTRK 240
NGSSLSDAGPPPISRSGAASMPSSPKQARKMSIQDSLALQPKLTRHKELASENINLRTRK
Sbjct: 181 NGSSLSDAGPPPISRSGAASMPSSPKQARKMSIQDSLALQPKLTRHKELASENINLRTRK 240
Query: 241 YSSSSLSHMGAYSRSLPRLYRATENQLTPLSLPPRNSLGNSKRTKLGEKDLPHSVIDNDN 300
YSSSSLSHMGAYSRSLPRLYRATENQLTPLSLPPRNSLGNSKRTKLGEKDLPHSVIDNDN
Sbjct: 241 YSSSSLSHMGAYSRSLPRLYRATENQLTPLSLPPRNSLGNSKRTKLGEKDLPHSVIDNDN 300
Query: 301 YLNFSSLSSGALPYKTSASEGNPYVSSTLSVPASPRVARKMLLASTSSCASDDFDQASYV 360
YLNFSSLSSGALPYKTSASEGNPYVSSTLSVPASPRVARKMLLASTSSCASDDFDQASYV
Sbjct: 301 YLNFSSLSSGALPYKTSASEGNPYVSSTLSVPASPRVARKMLLASTSSCASDDFDQASYV 360
Query: 361 GTNPSHSLLAGESDRVFATRRNFSCGSVEFDEADLESLRQASGTPQPALRERKSSISSIS 420
GTNPSHSLLAGESDRVFATRRNFSCGSVEFDEADLESLRQASGTPQPALRERKSSISSIS
Sbjct: 361 GTNPSHSLLAGESDRVFATRRNFSCGSVEFDEADLESLRQASGTPQPALRERKSSISSIS 420
Query: 421 GRDDLMDYHRRQREERLREQEMERLERQRLETILSLCAEYTKPDSRLSTGTTVEDVQKIN 480
GRDDLMDYHRRQREERLREQEMERLERQRLETILSLCAEYTKPDSRLSTGTTVEDVQKIN
Sbjct: 421 GRDDLMDYHRRQREERLREQEMERLERQRLETILSLCAEYTKPDSRLSTGTTVEDVQKIN 480
Query: 481 KELEKLQLSDEESVFEEALMSPDTRYRCHRKDSLPDADLASCGSLSQSSASFFTPRSTRN 540
KELEKLQLSDEESVFEEALMSPDTRYRCHRKDSLPDADLASCGSLSQSSASFFTPRSTRN
Sbjct: 481 KELEKLQLSDEESVFEEALMSPDTRYRCHRKDSLPDADLASCGSLSQSSASFFTPRSTRN 540
Query: 541 DELLSDLTRTPPPPSSTFPKASSESSYLSILPKTPEGISEEQRSQELAAMEETRIVILNN 600
DELLSDLTRTPPPPSSTFPKASSESSYLSILPKTPEGISEEQRSQELAAMEETRIVILNN
Sbjct: 541 DELLSDLTRTPPPPSSTFPKASSESSYLSILPKTPEGISEEQRSQELAAMEETRIVILNN 600
Query: 601 LEELKQKIKDINDQMDESFRELDMECALLDGEQKSETTELMKEKEILDHLNRKIAELEKN 660
LEELKQKIKDINDQMDESFRELDMECALLDGEQKSETTELMKEKEILDHLNRKIAELEKN
Sbjct: 601 LEELKQKIKDINDQMDESFRELDMECALLDGEQKSETTELMKEKEILDHLNRKIAELEKN 660
Query: 661 IVGEKTK-------------------------------------------DADLLDVESK 677
IVGEKTK DADLLDVESK
Sbjct: 661 IVGEKTKEKVKLDAEREKLERLQELYSEQKTQLDNCPESMREQLQQQLKRDADLLDVESK 720
Query: 678 HFEDLEFQQLEHESRLDEEKENLTQQLLREVAEYQRNIVSRKEKISALKKQANHIVQQAQ 737
HFEDLEFQQLEHESRLDEEKENLTQQLLREVAEYQRNIVSRKEKISALKKQANHIVQQAQ
Sbjct: 721 HFEDLEFQQLEHESRLDEEKENLTQQLLREVAEYQRNIVSRKEKISALKKQANHIVQQAQ 780
Query: 738 REQDHFVKEKNNLIMMLQREKENLCNLEKKYSSLSGGKGFPVNPNTLKEGYISVNEINEP 797
REQDHFVKEKNNLIMMLQREKENLCNLEKKYSSLSGGKGFPVNPNTLKEGYISVNEINEP
Sbjct: 781 REQDHFVKEKNNLIMMLQREKENLCNLEKKYSSLSGGKGFPVNPNTLKEGYISVNEINEP 840
Query: 798 CGNSTNLSPSTQFPADADAVATEPATAVLASQPQSKEHFRSLEERKKQHKEGLYLSDTLP 857
CGNSTNLSPSTQFPADADAVATEPATAVLASQPQSKEHFRSLEERKKQHKEGLYLSDTLP
Sbjct: 841 CGNSTNLSPSTQFPADADAVATEPATAVLASQPQSKEHFRSLEERKKQHKEGLYLSDTLP 900
Query: 858 RKKTTSSISPHFSSATMGRSITPKAHLPLGQSNSCGSVLPPSLAAMAKDSESRRMLRGYN 917
RKKTTSSISPHFSSATMGRSITPKAHLPLGQSNSCGSVLPPSLAAMAKDSESRRMLRGYN
Sbjct: 901 RKKTTSSISPHFSSATMGRSITPKAHLPLGQSNSCGSVLPPSLAAMAKDSESRRMLRGYN 960
Query: 918 HQQMSEGHRQKSEFYNRTASESNVYLNSFHYPDHSYKDQAFDTLSLDSSDSMETSISACS 977
HQQMSEGHRQKSEFYNRTASESNVYLNSFHYPDHSYKDQAFDTLSLDSSDSMETSISACS
Sbjct: 961 HQQMSEGHRQKSEFYNRTASESNVYLNSFHYPDHSYKDQAFDTLSLDSSDSMETSISACS 1020
Query: 978 PDNISSASTSNIARIEEMERLLKQAHAEKTRLLESREREMEAKKRALEEEKRRREILEKR 1037
PDNISSASTSNIARIEEMERLLKQAHAEKTRLLESREREMEAKKRALEEEKRRREILEKR
Sbjct: 1021 PDNISSASTSNIARIEEMERLLKQAHAEKTRLLESREREMEAKKRALEEEKRRREILEKR 1080
Query: 1038 LQEETSQRQKLIEKEVKIRERQRAQARPLTRYLPVRKEDFDLRSHVETAGHNIDTCYHVS 1097
LQEETSQRQKLIEKEVKIRERQRAQARPLTRYLPVRKEDFDLRSHVETAGHNIDTCYHVS
Sbjct: 1081 LQEETSQRQKLIEKEVKIRERQRAQARPLTRYLPVRKEDFDLRSHVETAGHNIDTCYHVS 1140
Query: 1098 ITEKTCRGFLIKMGGKIKTWKKRWFVFDRNKRTFSYYADKHETKLKGVIYFQAIEEVYYD 1157
ITEKTCRGFLIKMGGKIKTWKKRWFVFDRNKRTFSYYADKHETKLKGVIYFQAIEEVYYD
Sbjct: 1141 ITEKTCRGFLIKMGGKIKTWKKRWFVFDRNKRTFSYYADKHETKLKGVIYFQAIEEVYYD 1200
Query: 1158 HLKNANKSPNPLLTFSVKTHDRIYYMVAPSPEAMRIWMDVIVTGAEGYTHFLL 1210
HLKNANKSPNPLLTFSVKTHDRIYYMVAPSPEAMRIWMDVIVTGAEGYTHFLL
Sbjct: 1201 HLKNANKSPNPLLTFSVKTHDRIYYMVAPSPEAMRIWMDVIVTGAEGYTHFLL 1253
>gi|221219026 pleckstrin homology-like domain, family B, member 1
isoform b [Homo sapiens]
Length = 1319
Score = 657 bits (1695), Expect = 0.0
Identities = 390/838 (46%), Positives = 513/838 (61%), Gaps = 124/838 (14%)
Query: 407 PALRERKSSISSIS-GRDDLMDYHRRQREERLREQEMERLERQRLETILSLCAEYTKPDS 465
P RERK+SI+ IS DDL++YHRRQR+ERLREQEMERLERQRLETIL+LCAEY++ D
Sbjct: 570 PVTRERKNSITEISDNEDDLLEYHRRQRQERLREQEMERLERQRLETILNLCAEYSRADG 629
Query: 466 RLSTGTTVEDVQKINKELEKLQLSDEESVFEEALMSPDTRYRCHRKDSLPDADLASCGSL 525
G ++ I + L L+ P LA
Sbjct: 630 ----GPEAGELPSIGEATAALALAGRR----------------------PSRGLAGASGR 663
Query: 526 SQSSASFFTPRSTRNDELLSDLTRTPPPPSSTFPKASSESSYLSILPKTPEGISEEQRSQ 585
S T R + E SD SST S++ + E +
Sbjct: 664 SSEEPGVATQRLWESMER-SDEENLKEECSST---ESTQQEH--------EDAPSTKLQG 711
Query: 586 ELAAMEETRIVILNNLEELKQKIKDINDQMDESFRELDMECALLDGEQKSETTELMKEKE 645
E+ A+EE R +L ++E+LK ++K++ Q+ ES RE +ME ALL GE+++E L KE++
Sbjct: 712 EVLALEEERAQVLGHVEQLKVRVKELEQQLQESAREAEMERALLQGEREAERALLQKEQK 771
Query: 646 ILDHLNRKIAELEKNIVGEKTKDADLLDVESKHFEDLEFQQLEHESRLDEEKENLTQQLL 705
+D L K+ LE I E+ K+A+ L+ E+K FEDLEFQQLE ESR++EE+E Q LL
Sbjct: 772 AVDQLQEKLVALETGIQKERDKEAEALETETKLFEDLEFQQLERESRVEEERELAGQGLL 831
Query: 706 REVAEYQRNIVSRKEKISALKKQANHIVQQAQREQDHFVKEKNNLIMMLQREKENLCNLE 765
R AE R+I RKE+++ L QA I QA +E + ++KN + +LQ+EKE L LE
Sbjct: 832 RSKAELLRSIAKRKERLAILDSQAGQIRAQAVQESERLARDKNASLQLLQKEKEKLTVLE 891
Query: 766 KKYSSLSGGKGFPVNPNTLKEGYISVNEINEPCGNSTNLSPSTQFPADADAVATEPATAV 825
++Y SL+GG+ FP +TLKE Y S + G +T+ P T+
Sbjct: 892 RRYHSLTGGRPFPKTTSTLKEVYRSKMD-----GEATSPLPRTR---------------- 930
Query: 826 LASQPQSKEHFRSLEERKKQHKEGLYLSDTLPRKKTTSSISPHFSSATMGRSITPKAHLP 885
S LP +SS S S AT+GRS +PK+ L
Sbjct: 931 ---------------------------SGPLPSSSGSSSSSSQLSVATLGRSPSPKSALL 963
Query: 886 LGQSNSCGSVLPPSLAAMAKDSESRRML--RGYNHQQMSEGHRQKSEFYNRTASESNVYL 943
N GS LP +LAA +D E++R L + Q + E R+ +E + A+E+
Sbjct: 964 T--QNGTGS-LPRNLAATLQDIETKRQLALQQKGQQVIEEQRRRLAELKQKAAAEAQCQW 1020
Query: 944 NSFH-----------YPD---HSYK-------------DQAFDTLSLDSSDSMETSIS-- 974
++ H +P HS + A+DTLSL+SSDSMETSIS
Sbjct: 1021 DALHGAAPFPAGPSGFPPLMHHSILHHLPAGRERGEEGEHAYDTLSLESSDSMETSISTG 1080
Query: 975 ---ACSPDNISSASTSNIARIEEMERLLKQAHAEKTRLLESREREMEAKKRALEEEKRRR 1031
ACSPDN+SSAS ++ +IEEME++LK+AHAEK RL+ESREREME +++ALEEE+RRR
Sbjct: 1081 GNSACSPDNMSSASGLDMGKIEEMEKMLKEAHAEKNRLMESREREMELRRQALEEERRRR 1140
Query: 1032 EILEKRLQEETSQRQKLIEKEVKIRERQRAQARPLTRYLPVRKEDFDLRSHVETAGHNID 1091
E +E+RLQ E+++RQ+L+EKEVK+RE+Q +QARPLTRYLP+RKEDFDL++H+E++GH +D
Sbjct: 1141 EQVERRLQSESARRQQLVEKEVKMREKQFSQARPLTRYLPIRKEDFDLKTHIESSGHGVD 1200
Query: 1092 TCYHVSITEKTCRGFLIKMGGKIKTWKKRWFVFDRNKRTFSYYADKHETKLKGVIYFQAI 1151
TC HV ++ K CRG+L+KMGGKIK+WKKRWFVFDR KRT SYY DKHETKLKGVIYFQAI
Sbjct: 1201 TCLHVVLSSKVCRGYLVKMGGKIKSWKKRWFVFDRLKRTLSYYVDKHETKLKGVIYFQAI 1260
Query: 1152 EEVYYDHLKNANKSPNPLLTFSVKTHDRIYYMVAPSPEAMRIWMDVIVTGAEGYTHFL 1209
EEVYYDHL++A KSPNP LTF VKTHDR+YYMVAPS EAMRIWMDVIVTGAEGYT F+
Sbjct: 1261 EEVYYDHLRSAAKSPNPALTFCVKTHDRLYYMVAPSAEAMRIWMDVIVTGAEGYTQFM 1318
>gi|221219024 pleckstrin homology-like domain, family B, member 1
isoform a [Homo sapiens]
Length = 1377
Score = 652 bits (1683), Expect = 0.0
Identities = 392/850 (46%), Positives = 524/850 (61%), Gaps = 90/850 (10%)
Query: 407 PALRERKSSISSIS-GRDDLMDYHRRQREERLREQEMERLERQRLETILSLCAEYTKPDS 465
P RERK+SI+ IS DDL++YHRRQR+ERLREQEMERLERQRLETIL+LCAEY++ D
Sbjct: 570 PVTRERKNSITEISDNEDDLLEYHRRQRQERLREQEMERLERQRLETILNLCAEYSRADG 629
Query: 466 RLSTGTTVEDVQKINKELEKLQLSDEESVFEEALMSPDTRYRCHRKDSLPDADLASCGSL 525
G ++ I + L L+ P LA
Sbjct: 630 ----GPEAGELPSIGEATAALALAGRR----------------------PSRGLAGASGR 663
Query: 526 SQSSASFFTPRSTRNDELLSDLTRTPPPPSSTFPKASSESSYLSILPKTPEGISEEQRSQ 585
S T R + E SD SST S++ + E +
Sbjct: 664 SSEEPGVATQRLWESMER-SDEENLKEECSST---ESTQQEH--------EDAPSTKLQG 711
Query: 586 ELAAMEETRIVILNNLEELKQKIKDINDQMDESFRELDMECALLDGEQKSETTELMKEKE 645
E+ A+EE R +L ++E+LK ++K++ Q+ ES RE +ME ALL GE+++E L KE++
Sbjct: 712 EVLALEEERAQVLGHVEQLKVRVKELEQQLQESAREAEMERALLQGEREAERALLQKEQK 771
Query: 646 ILDHLNRKIAELEKNIVGEKTKDADLLDVESKHFEDLEFQQLEHESRLDEEKENLTQQLL 705
+D L K+ LE I E+ K+A+ L+ E+K FEDLEFQQLE ESR++EE+E Q LL
Sbjct: 772 AVDQLQEKLVALETGIQKERDKEAEALETETKLFEDLEFQQLERESRVEEERELAGQGLL 831
Query: 706 REVAEYQRNIVSRKEKISALKKQANHIVQQAQREQDHFVKEKNNLIMMLQREKENLCNLE 765
R AE R+I RKE+++ L QA I QA +E + ++KN + +LQ+EKE L LE
Sbjct: 832 RSKAELLRSIAKRKERLAILDSQAGQIRAQAVQESERLARDKNASLQLLQKEKEKLTVLE 891
Query: 766 KKYSSLSGGKGFPVNPNTLKE-GYISVNEINEPCGNSTNLSPSTQFPADADAVATEPATA 824
++Y SL+GG+ FP +TLKE + + ++ ++ PA A ++ P
Sbjct: 892 RRYHSLTGGRPFPKTTSTLKEMEKLLLPAVDLEQWYQELMAGLGTGPAAASPHSSPPPLP 951
Query: 825 VLASQPQSKEHFRSLEERKKQHKEGLYLSDTLPRKKTTSSISPHFSSATMGRSITPKAHL 884
AS+ + +RS + + S LP +SS S S AT+GRS +PK+ L
Sbjct: 952 AKASR--QLQVYRSKMDGEATSPLPRTRSGPLPSSSGSSSSSSQLSVATLGRSPSPKSAL 1009
Query: 885 PLGQSNSCGSVLPPSLAAMAKDSESRRML--RGYNHQQMSEGHRQKSEFYNRTASESNVY 942
N GS LP +LAA +D E++R L + Q + E R+ +E + A+E+
Sbjct: 1010 LT--QNGTGS-LPRNLAATLQDIETKRQLALQQKGQQVIEEQRRRLAELKQKAAAEAQCQ 1066
Query: 943 LNSFH-----------YPD---HSYK-------------DQAFDTLSLDSSDSMETSIS- 974
++ H +P HS + A+DTLSL+SSDSMETSIS
Sbjct: 1067 WDALHGAAPFPAGPSGFPPLMHHSILHHLPAGRERGEEGEHAYDTLSLESSDSMETSIST 1126
Query: 975 ----ACSPDNISSASTSNIARIEEMERLLKQAHAEKTRLLESREREMEAKKRALEEEKRR 1030
ACSPDN+SSAS ++ +IEEME++LK+AHAEK RL+ESREREME +++ALEEE+RR
Sbjct: 1127 GGNSACSPDNMSSASGLDMGKIEEMEKMLKEAHAEKNRLMESREREMELRRQALEEERRR 1186
Query: 1031 REILEKRLQEETSQRQKLIEKEVKIRERQRAQARPLTRYLPVRKEDFDLRSHVETAGHNI 1090
RE +E+RLQ E+++RQ+L+EKEVK+RE+Q +QARPLTRYLP+RKEDFDL++H+E++GH +
Sbjct: 1187 REQVERRLQSESARRQQLVEKEVKMREKQFSQARPLTRYLPIRKEDFDLKTHIESSGHGV 1246
Query: 1091 DTCYHVSITEKTCRGFLIKMGGKIKTWKKRWFVFDRNKRTFSYYADKHETKLKGVIYFQA 1150
DTC HV ++ K CRG+L+KMGGKIK+WKKRWFVFDR KRT SYY DKHETKLKGVIYFQA
Sbjct: 1247 DTCLHVVLSSKVCRGYLVKMGGKIKSWKKRWFVFDRLKRTLSYYVDKHETKLKGVIYFQA 1306
Query: 1151 IEEVYYDHLKNANK-----------SPNPLLTFSVKTHDRIYYMVAPSPEAMRIWMDVIV 1199
IEEVYYDHL++A K SPNP LTF VKTHDR+YYMVAPS EAMRIWMDVIV
Sbjct: 1307 IEEVYYDHLRSAAKKRFFRFTMVTESPNPALTFCVKTHDRLYYMVAPSAEAMRIWMDVIV 1366
Query: 1200 TGAEGYTHFL 1209
TGAEGYT F+
Sbjct: 1367 TGAEGYTQFM 1376
>gi|38424073 pleckstrin homology-like domain, family B, member 1
isoform a [Homo sapiens]
Length = 1377
Score = 652 bits (1683), Expect = 0.0
Identities = 392/850 (46%), Positives = 524/850 (61%), Gaps = 90/850 (10%)
Query: 407 PALRERKSSISSIS-GRDDLMDYHRRQREERLREQEMERLERQRLETILSLCAEYTKPDS 465
P RERK+SI+ IS DDL++YHRRQR+ERLREQEMERLERQRLETIL+LCAEY++ D
Sbjct: 570 PVTRERKNSITEISDNEDDLLEYHRRQRQERLREQEMERLERQRLETILNLCAEYSRADG 629
Query: 466 RLSTGTTVEDVQKINKELEKLQLSDEESVFEEALMSPDTRYRCHRKDSLPDADLASCGSL 525
G ++ I + L L+ P LA
Sbjct: 630 ----GPEAGELPSIGEATAALALAGRR----------------------PSRGLAGASGR 663
Query: 526 SQSSASFFTPRSTRNDELLSDLTRTPPPPSSTFPKASSESSYLSILPKTPEGISEEQRSQ 585
S T R + E SD SST S++ + E +
Sbjct: 664 SSEEPGVATQRLWESMER-SDEENLKEECSST---ESTQQEH--------EDAPSTKLQG 711
Query: 586 ELAAMEETRIVILNNLEELKQKIKDINDQMDESFRELDMECALLDGEQKSETTELMKEKE 645
E+ A+EE R +L ++E+LK ++K++ Q+ ES RE +ME ALL GE+++E L KE++
Sbjct: 712 EVLALEEERAQVLGHVEQLKVRVKELEQQLQESAREAEMERALLQGEREAERALLQKEQK 771
Query: 646 ILDHLNRKIAELEKNIVGEKTKDADLLDVESKHFEDLEFQQLEHESRLDEEKENLTQQLL 705
+D L K+ LE I E+ K+A+ L+ E+K FEDLEFQQLE ESR++EE+E Q LL
Sbjct: 772 AVDQLQEKLVALETGIQKERDKEAEALETETKLFEDLEFQQLERESRVEEERELAGQGLL 831
Query: 706 REVAEYQRNIVSRKEKISALKKQANHIVQQAQREQDHFVKEKNNLIMMLQREKENLCNLE 765
R AE R+I RKE+++ L QA I QA +E + ++KN + +LQ+EKE L LE
Sbjct: 832 RSKAELLRSIAKRKERLAILDSQAGQIRAQAVQESERLARDKNASLQLLQKEKEKLTVLE 891
Query: 766 KKYSSLSGGKGFPVNPNTLKE-GYISVNEINEPCGNSTNLSPSTQFPADADAVATEPATA 824
++Y SL+GG+ FP +TLKE + + ++ ++ PA A ++ P
Sbjct: 892 RRYHSLTGGRPFPKTTSTLKEMEKLLLPAVDLEQWYQELMAGLGTGPAAASPHSSPPPLP 951
Query: 825 VLASQPQSKEHFRSLEERKKQHKEGLYLSDTLPRKKTTSSISPHFSSATMGRSITPKAHL 884
AS+ + +RS + + S LP +SS S S AT+GRS +PK+ L
Sbjct: 952 AKASR--QLQVYRSKMDGEATSPLPRTRSGPLPSSSGSSSSSSQLSVATLGRSPSPKSAL 1009
Query: 885 PLGQSNSCGSVLPPSLAAMAKDSESRRML--RGYNHQQMSEGHRQKSEFYNRTASESNVY 942
N GS LP +LAA +D E++R L + Q + E R+ +E + A+E+
Sbjct: 1010 LT--QNGTGS-LPRNLAATLQDIETKRQLALQQKGQQVIEEQRRRLAELKQKAAAEAQCQ 1066
Query: 943 LNSFH-----------YPD---HSYK-------------DQAFDTLSLDSSDSMETSIS- 974
++ H +P HS + A+DTLSL+SSDSMETSIS
Sbjct: 1067 WDALHGAAPFPAGPSGFPPLMHHSILHHLPAGRERGEEGEHAYDTLSLESSDSMETSIST 1126
Query: 975 ----ACSPDNISSASTSNIARIEEMERLLKQAHAEKTRLLESREREMEAKKRALEEEKRR 1030
ACSPDN+SSAS ++ +IEEME++LK+AHAEK RL+ESREREME +++ALEEE+RR
Sbjct: 1127 GGNSACSPDNMSSASGLDMGKIEEMEKMLKEAHAEKNRLMESREREMELRRQALEEERRR 1186
Query: 1031 REILEKRLQEETSQRQKLIEKEVKIRERQRAQARPLTRYLPVRKEDFDLRSHVETAGHNI 1090
RE +E+RLQ E+++RQ+L+EKEVK+RE+Q +QARPLTRYLP+RKEDFDL++H+E++GH +
Sbjct: 1187 REQVERRLQSESARRQQLVEKEVKMREKQFSQARPLTRYLPIRKEDFDLKTHIESSGHGV 1246
Query: 1091 DTCYHVSITEKTCRGFLIKMGGKIKTWKKRWFVFDRNKRTFSYYADKHETKLKGVIYFQA 1150
DTC HV ++ K CRG+L+KMGGKIK+WKKRWFVFDR KRT SYY DKHETKLKGVIYFQA
Sbjct: 1247 DTCLHVVLSSKVCRGYLVKMGGKIKSWKKRWFVFDRLKRTLSYYVDKHETKLKGVIYFQA 1306
Query: 1151 IEEVYYDHLKNANK-----------SPNPLLTFSVKTHDRIYYMVAPSPEAMRIWMDVIV 1199
IEEVYYDHL++A K SPNP LTF VKTHDR+YYMVAPS EAMRIWMDVIV
Sbjct: 1307 IEEVYYDHLRSAAKKRFFRFTMVTESPNPALTFCVKTHDRLYYMVAPSAEAMRIWMDVIV 1366
Query: 1200 TGAEGYTHFL 1209
TGAEGYT F+
Sbjct: 1367 TGAEGYTQFM 1376
>gi|157266264 pleckstrin homology-like domain, family B, member 3
[Homo sapiens]
Length = 640
Score = 201 bits (510), Expect = 5e-51
Identities = 111/212 (52%), Positives = 130/212 (61%), Gaps = 31/212 (14%)
Query: 992 IEEMERLLKQAHAEKTRLLESREREMEAKKRALEEEKRRREILEKRLQEETSQRQKLIEK 1051
I MERLL+QA AE+ RLL++R E +R E
Sbjct: 455 IAHMERLLQQAMAERERLLKAR----EGTRRGTEGSSG---------------------- 488
Query: 1052 EVKIRERQRAQARPLTRYLPVRKEDFDLRSHVETAGHNIDTCYHVSITEKTCRGFLIKMG 1111
A P T P DLR H+E GHN + C HV ++ CRG L+KMG
Sbjct: 489 -----PAVPAITAPPTPPHPPGPRILDLRQHLEGWGHNPENCPHVQVSGCCCRGPLVKMG 543
Query: 1112 GKIKTWKKRWFVFDRNKRTFSYYADKHETKLKGVIYFQAIEEVYYDHLKNANKSPNPLLT 1171
G+IKTW+KRWF FDR R +YYADK ETKLKGVIYFQAIEEVYYDHL+ A KSPNP LT
Sbjct: 544 GRIKTWRKRWFCFDRQARRLAYYADKEETKLKGVIYFQAIEEVYYDHLRCAFKSPNPRLT 603
Query: 1172 FSVKTHDRIYYMVAPSPEAMRIWMDVIVTGAE 1203
F VKT++R++YMVAPSPEAMRIWMDVIVT A+
Sbjct: 604 FCVKTYERLFYMVAPSPEAMRIWMDVIVTAAD 635
Score = 67.4 bits (163), Expect = 8e-11
Identities = 95/418 (22%), Positives = 165/418 (39%), Gaps = 109/418 (26%)
Query: 550 TPPPPSSTFPKASSESSYLSILPKTPEGISEEQRSQELAAMEETRIVILNNLEELKQKIK 609
TPP + P AS+ S + G + + Q+L A+ TR+ ++ +Q++K
Sbjct: 75 TPPIAMAATPPASTSSR------EGVRGAARRLQGQQLEAL--TRVALM------EQRVK 120
Query: 610 DINDQMDESFRELDMECALLDGEQKSETTELMKEKEILDHL------------------N 651
++ Q E E+++E ALL GE E +E+E L L
Sbjct: 121 ELQRQRKELRIEMEVEVALLRGELAGERVAARREEEQLRELLEQQAASEQRGRQQREQEQ 180
Query: 652 RKIAELEKNIVG--EKTKDA-----------------------DLLDVESKHFEDLEFQQ 686
R++++ + G ++ + A + LDV + +EDLEFQQ
Sbjct: 181 RRLSQERDRLEGLRQRLRKAQGQLDSQPEDQRERLLQGVQEMREQLDVAQRAYEDLEFQQ 240
Query: 687 LEHESRLDEEKEN---------LTQQLLREVAEYQRNIVSRKEKISALKKQANHIVQQAQ 737
LE ESR +EE + Q+L +A+++R + + +I L++Q + +Q
Sbjct: 241 LERESRQEEEDRDSPGPQVPDPKVQELQASMAQHRRGAL--QHRIRVLEEQLKSLGEQMA 298
Query: 738 REQDHFVKEKNNLIMMLQREKENLCNLEKKYSSLSGGKGFPVNPNTLKEGYISVNEINEP 797
E ++K + L +E+ L L + L G G + +EP
Sbjct: 299 AESRGLSRKKEEALQALSQERSRLLEL----NCLQGTPG---------------GDFSEP 339
Query: 798 CGNSTNLSPSTQFPADADAVATEPATAVLASQPQSKEHFRSLEERKKQHKEGLYLSDTLP 857
T L + + D + + A A A+ P S F Q GL + +LP
Sbjct: 340 NPALTKLLFTQK--TDRQLLVLQDAVAHSAATPTSSCLFS--VHSSLQGSIGLQRTGSLP 395
Query: 858 RKK--------TTSSISPHFSSATMGRSITP----KAHLPL------GQSNSCGSVLP 897
RK+ + +S H + + ++ P PL G+ NSCG++ P
Sbjct: 396 RKRGERGSQRGSPRPLSFHCTESLEASALPPAVGDSGRYPLYQLLNCGRGNSCGAIHP 453
>gi|55770888 early endosome antigen 1, 162kD [Homo sapiens]
Length = 1411
Score = 67.4 bits (163), Expect = 8e-11
Identities = 139/673 (20%), Positives = 269/673 (39%), Gaps = 94/673 (13%)
Query: 431 RQREERLREQEMERLERQRLETILSLCAEYTKPDSRLSTGTTVEDVQ-KINKELEKL-QL 488
+Q +E L +Q E+ R D LS T+V ++ ++N+ EK+ QL
Sbjct: 592 KQAQENLHDQVQEQKAHLR-----------AAQDRVLSLETSVNELNSQLNESKEKVSQL 640
Query: 489 SDEESVFEEALMSPDTRYRCHRKDSLPDADLASCGSLSQSSASFFTPRSTRNDELLSDLT 548
+ E L+S + R D D A + Q +T+ D++ + L
Sbjct: 641 DIQIKAKTELLLSAEAAKTAQRADLQNHLDTAQ--NALQDKQQELNKITTQLDQVTAKLQ 698
Query: 549 RTPPPPSSTFPKASS-ESSYLSILPKTPEGISE----EQRSQELAAMEETRIVILNNLEE 603
S + YLS+ KT E + E S E+ A +E L +L++
Sbjct: 699 DKQEHCSQLESHLKEYKEKYLSLEQKTEELEGQIKKLEADSLEVKASKEQA---LQDLQQ 755
Query: 604 LKQKIKDINDQMDESFRELDMECAL-----LDGEQKSETTELMKEKEILDHLNRKIAELE 658
+Q D+ + E ++L+ME + LD ++KSE E +K+K ++I + +
Sbjct: 756 QRQLNTDLELRATELSKQLEMEKEIVSSTRLDLQKKSEALESIKQKLTKQEEEKQILKQD 815
Query: 659 KNIVGEKTK--DADLLDVESKHFEDLEFQQLEHESRLDE------EKENLTQQLLREVAE 710
+ ++TK +L + +L+ ++E E+ + E + ++ L +E
Sbjct: 816 FETLSQETKIQHEELNNRIQTTVTELQKVKMEKEALMTELSTVKDKLSKVSDSLKNSKSE 875
Query: 711 YQRNIVSRKEKISALKKQANHIVQQAQREQDHFVKEKNNLIMMLQREKENLCNLEKKYSS 770
+++ K I L+K + Q Q + ++ +KE+ L L++EKE L+ + +S
Sbjct: 876 FEKENQKGKAAILDLEKTCKELKHQLQVQMENTLKEQKELKKSLEKEKEASHQLKLELNS 935
Query: 771 LSGGKGFPVNPNTLKEGYISVNEINEPCGNSTNLSPST-QFPADADAVATEPATAVL--- 826
+ + NTLK+ + E + GN L S+ Q +A+ E AVL
Sbjct: 936 MQ--EQLIQAQNTLKQ---NEKEEQQLQGNINELKQSSEQKKKQIEALQGELKIAVLQKT 990
Query: 827 ------------ASQPQSKE---------HFRSLEERKKQHKEGLY--LSDTLPRKKTTS 863
A+Q + E ++ +E KQ + Y S+ L ++
Sbjct: 991 ELENKLQQQLTQAAQELAAEKEKISVLQNNYEKSQETFKQLQSDFYGRESELLATRQDLK 1050
Query: 864 SISPHFSSATMGRSITPKAHLPLGQSNSCGSVLPPSLAAMAKDSESRRMLRGYNHQQMSE 923
S+ S + + +G N L + A + +DS + QQ+ E
Sbjct: 1051 SVEEKLS---LAQEDLISNRNQIGNQNKLIQELKTAKATLEQDSAKK-------EQQLQE 1100
Query: 924 GHRQKSEFYNRTASESNVYLNSFHYPDHSYKDQAFDTLSLDSSDSMETSISACSPDNISS 983
+ + + + +N K + + + E + +
Sbjct: 1101 RCKALQDIQKEKSLKEKELVNE--------KSKLAEIEEIKCRQEKEITKLNEELKSHKL 1152
Query: 984 ASTSNIARIEEMERLLKQAHAEKTRLLESREREMEAKKRALEEEKRRREILEKRL-QEET 1042
S I +++ ++LL Q E + + ++ K A+E+EKR ++IL+ ++ +EE
Sbjct: 1153 ESIKEITNLKDAKQLLIQQKLE-------LQGKADSLKAAVEQEKRNQQILKDQVKKEEE 1205
Query: 1043 SQRQKLIEKEVKI 1055
+++ IEKE K+
Sbjct: 1206 ELKKEFIEKEAKL 1218
Score = 61.2 bits (147), Expect = 6e-09
Identities = 144/732 (19%), Positives = 285/732 (38%), Gaps = 87/732 (11%)
Query: 386 GSVEFDEADLESLRQASGTPQPA---LRERKSSISSISGR--DDLMDYHRRQREERLREQ 440
G V A+L+SL Q Q +++ K + + ++ D + EER +
Sbjct: 128 GLVTDSSAELQSLEQQLEEAQTENFNIKQMKDLFEQKAAQLATEIADIKSKYDEERSLRE 187
Query: 441 EMERLERQRLETILSLCAEYTKPDSRLSTGTTVEDVQKINKELEKLQLSDEESVFEEALM 500
E+ + E + + L +EDV + KEL ++Q + E
Sbjct: 188 AAEQKVTRLTEELNKEATVIQDLKTELLQRPGIEDVAVLKKELVQVQTLMDNMTLERERE 247
Query: 501 SPDTRYRCHRKDSLPDADLASCGSLSQSSA-----------------SFFTPRSTRNDEL 543
S + C + S + A+ L A S + +N L
Sbjct: 248 SEKLKDECKKLQSQYASSEATISQLRSELAKGPQEVAVYVQELQKLKSSVNELTQKNQTL 307
Query: 544 LSDLTRTPPPPSSTFPKASSESSYLSILPKT--PEGISEEQRSQELAAMEET--RI-VIL 598
+L + + K + ES + T + + +Q L+A E + RI V L
Sbjct: 308 TENLLKKEQDYTKLEEKHNEESVSKKNIQATLHQKDLDCQQLQSRLSASETSLHRIHVEL 367
Query: 599 NNLEELKQKIKDINDQMDESFRELDMECALLDGEQKSETTELMKEKEILDHLNRKIAELE 658
+ E QK+K+ +++ ++ L E L +++ + ++ + ++ L+ K+ E E
Sbjct: 368 SEKGEATQKLKEELSEVETKYQHLKAEFKQLQQQREEKEQHGLQLQSEINQLHSKLLETE 427
Query: 659 KNIVGEKTKDADLLDVESKHFEDLEFQQLEHE---SRLDEE-KENLT-----QQLLREVA 709
+ + + + + S+ D E Q + + SRL+E+ KE +T Q L +
Sbjct: 428 RQLGEAHGRLKEQRQLSSEKLMDKEQQVADLQLKLSRLEEQLKEKVTNSTELQHQLDKTK 487
Query: 710 EYQRNIVSRKEKISALKKQANHIVQQAQREQDHFVKEKNNLIMMLQREKENLCNLEKK-- 767
+ + + ++ +A ++A + ++Q R+ ++ NL +LQ+ KEN+ LEK+
Sbjct: 488 QQHQEQQALQQSTTAKLREAQNDLEQVLRQIGDKDQKIQNLEALLQKSKENISLLEKERE 547
Query: 768 --YSSLSGGKGFPVNPNTLKEGYISVNEINEPCGNSTNLSPSTQFPADADAVATEPATAV 825
Y+ + G+G N L+E ++ E T L+ + +++ A E
Sbjct: 548 DLYAKIQAGEGETAVLNQLQEKNHTLQE------QVTQLTEKLKNQSESHKQAQENLHDQ 601
Query: 826 LASQPQSKEHFRSLEER--------------KKQHKEGLYLSDTLPRKKTTSSISPHFSS 871
+ Q K H R+ ++R + KE + D + KT +S +
Sbjct: 602 VQEQ---KAHLRAAQDRVLSLETSVNELNSQLNESKEKVSQLDIQIKAKTELLLSA--EA 656
Query: 872 ATMGRSITPKAHLPLGQSNSCGSVLPPSLAAMAKDSESRRMLRGYNHQQMSEGHRQKSEF 931
A + + HL Q+ A K E ++ + Q++ + K E
Sbjct: 657 AKTAQRADLQNHLDTAQN-----------ALQDKQQELNKITTQLD--QVTAKLQDKQEH 703
Query: 932 YNRTASESNVYLNSFHYPDHSYKDQAFDTLSLDSSDSMETSIS-ACSPDNISSASTSNIA 990
++ S Y + + ++ L+ +DS+E S + ++ N
Sbjct: 704 CSQLESHLKEYKEKYLSLEQKTEELEGQIKKLE-ADSLEVKASKEQALQDLQQQRQLNTD 762
Query: 991 RIEEMERLLKQAHAEK-----TRL-LESREREMEAKKRALEEEKRRREILEKRLQEETSQ 1044
L KQ EK TRL L+ + +E+ K+ L +++ ++IL++ E SQ
Sbjct: 763 LELRATELSKQLEMEKEIVSSTRLDLQKKSEALESIKQKLTKQEEEKQILKQDF-ETLSQ 821
Query: 1045 RQKLIEKEVKIR 1056
K+ +E+ R
Sbjct: 822 ETKIQHEELNNR 833
Score = 48.5 bits (114), Expect = 4e-05
Identities = 78/395 (19%), Positives = 162/395 (41%), Gaps = 52/395 (13%)
Query: 393 ADLESLRQASGTPQPALRERKSSISSISGRDDLMDYHRRQREERLREQEMERLERQRLET 452
A L+ T Q AL++++ ++ I+ + D + + ++E + E E +
Sbjct: 660 AQRADLQNHLDTAQNALQDKQQELNKITTQLDQVTAKLQDKQEHCSQLESHLKEYK---- 715
Query: 453 ILSLCAEYTKPDSRLSTGTTVEDVQKINKELEKLQLSDEESVFEEALMSPDTRYRCHRKD 512
+ LS E+++ K+LE L + S E+AL + + +
Sbjct: 716 -----------EKYLSLEQKTEELEGQIKKLEADSLEVKASK-EQALQDLQQQRQLNTDL 763
Query: 513 SLPDADLASCGSLSQSSASFFTPRSTRNDELLSDLTRTPPPPSSTFPKASSESSYLSILP 572
L +L+ + + S STR DL + S K + + IL
Sbjct: 764 ELRATELSKQLEMEKEIVS-----STR-----LDLQKKSEALESIKQKLTKQEEEKQILK 813
Query: 573 KTPEGISEEQRSQ-------------ELAAMEETRIVILNNLEELKQKIKDINDQMDESF 619
+ E +S+E + Q EL ++ + ++ L +K K+ ++D + S
Sbjct: 814 QDFETLSQETKIQHEELNNRIQTTVTELQKVKMEKEALMTELSTVKDKLSKVSDSLKNSK 873
Query: 620 RELDME-----CALLDGEQKSETTELMKEKEI-LDHLNRKIAELEKNIVGEKTKDADLLD 673
E + E A+LD E+ + EL + ++ +++ ++ EL+K++ EK L
Sbjct: 874 SEFEKENQKGKAAILDLEKTCK--ELKHQLQVQMENTLKEQKELKKSLEKEKEASHQL-- 929
Query: 674 VESKHFEDLEFQQLEHESRLDEEKENLTQQLLREVAEYQRNIVSRKEKISALKKQANHIV 733
++ Q ++ ++ L ++ E QQL + E +++ +K++I AL+ + V
Sbjct: 930 --KLELNSMQEQLIQAQNTL-KQNEKEEQQLQGNINELKQSSEQKKKQIEALQGELKIAV 986
Query: 734 QQAQREQDHFVKEKNNLIMMLQREKENLCNLEKKY 768
Q ++ ++ L EKE + L+ Y
Sbjct: 987 LQKTELENKLQQQLTQAAQELAAEKEKISVLQNNY 1021
>gi|41406064 myosin, heavy polypeptide 10, non-muscle [Homo sapiens]
Length = 1976
Score = 64.7 bits (156), Expect = 5e-10
Identities = 102/496 (20%), Positives = 201/496 (40%), Gaps = 79/496 (15%)
Query: 591 EETRIVILNNLEELKQKIKDINDQMDE---SFRELDMECALLDGEQKSETTELM------ 641
EE ++ N ++++ I+D+ +Q+DE + ++L +E + + K E++
Sbjct: 935 EERNQILQNEKKKMQAHIQDLEEQLDEEEGARQKLQLEKVTAEAKIKKMEEEILLLEDQN 994
Query: 642 ----KEKEILDHLNRKIAELEKNIVGEKTKDADLLDVESKH---FEDLEFQQLEHESRLD 694
KEK++++ +IAE + E+ K +L + +K DLE ++L+ E +
Sbjct: 995 SKFIKEKKLMED---RIAECSSQLAEEEEKAKNLAKIRNKQEVMISDLE-ERLKKEEKTR 1050
Query: 695 EEKENLTQQLLREVAEYQRNIVSRKEKISALKKQA---NHIVQQAQREQDHFVKEKNNLI 751
+E E ++L E + Q I + +I LK Q +Q A D KNN +
Sbjct: 1051 QELEKAKRKLDGETTDLQDQIAELQAQIDELKLQLAKKEEELQGALARGDDETLHKNNAL 1110
Query: 752 MMLQREKENLCNLEKKYSSLSGGKGFPVNPNTLKEGYISVNEINEPCGNSTNLSPSTQFP 811
+++ + + L++ + S + N ++ ++E E T+
Sbjct: 1111 KVVRELQAQIAELQEDFESEKASR------NKAEKQKRDLSEELEAL--------KTELE 1156
Query: 812 ADADAVATEPATAVLASQPQSKEHFRSLEERKKQHKEGLYLSDTLPRKKTT-SSISPHFS 870
D A + Q + E ++LEE K H+ + D R T +S
Sbjct: 1157 DTLDTTAAQQELRTKREQ-EVAELKKALEEETKNHEA--QIQDMRQRHATALEELSEQLE 1213
Query: 871 SATMGRSITPKAHLPLGQSNSCGSVLPPSLAAMAKDSESRRMLRGYN----HQQMSEGHR 926
A ++ K L N + L + +SE +R H ++SEG R
Sbjct: 1214 QAKRFKANLEKNKQGLETDNKELACEVKVLQQVKAESEHKRKKLDAQVQELHAKVSEGDR 1273
Query: 927 QKSEFYNRTASESNVYLNSFHYPDHSYKDQAFDTLSLDSSDSMETSISACSPDNISSA-- 984
+ E + + N D++ T + I A
Sbjct: 1274 LRVELAEKASKLQN------------------------ELDNVSTLLEEAEKKGIKFAKD 1309
Query: 985 STSNIARIEEMERLLKQAHAEKTRLLESREREMEAKKRAL----EEEKRRREILEKR--- 1037
+ S +++++ + LL++ +K L SR R++E +K +L EEE+ R+ LEK+
Sbjct: 1310 AASLESQLQDTQELLQEETRQKLNL-SSRIRQLEEEKNSLQEQQEEEEEARKNLEKQVLA 1368
Query: 1038 LQEETSQRQKLIEKEV 1053
LQ + + +K ++ ++
Sbjct: 1369 LQSQLADTKKKVDDDL 1384
Score = 48.5 bits (114), Expect = 4e-05
Identities = 140/707 (19%), Positives = 270/707 (38%), Gaps = 94/707 (13%)
Query: 367 SLLAGESDRVFATRRNFSCGSVEF--DEADLESLRQASGTPQPALRERKSSISSISGRDD 424
S L E D V ++F D A LES Q + Q L+E ++S R
Sbjct: 1283 SKLQNELDNVSTLLEEAEKKGIKFAKDAASLESQLQDT---QELLQEETRQKLNLSSRIR 1339
Query: 425 LMDYHRRQREERLREQEMER--LERQRLETILSLCAEYTKPDSRLSTGTTVEDVQK-INK 481
++ + +E+ E+E R LE+Q L L K D L T ++E+ +K + K
Sbjct: 1340 QLEEEKNSLQEQQEEEEEARKNLEKQVLALQSQLADTKKKVDDDLGTIESLEEAKKKLLK 1399
Query: 482 ELEKL-QLSDEESVFEEALMSPDTRYRCHRKDSLPDADLASCGSLSQSSASFFTPRSTRN 540
+ E L Q +E+++ + L R + D D D + AS + +
Sbjct: 1400 DAEALSQRLEEKALAYDKLEKTKNRLQQELDDLTVDLDH------QRQVASNLEKKQKKF 1453
Query: 541 DELLSDLTRTPPPPSSTFPKASSESSYLSILPKTPEGISEEQRSQE-LAAMEETRIVILN 599
D+LL++ + +A +E+ K + +S + +E L A EE
Sbjct: 1454 DQLLAEEKSISARYAEERDRAEAEAR-----EKETKALSLARALEEALEAKEEFE----R 1504
Query: 600 NLEELKQKIKDI---NDQMDESFRELDMECALLDGEQKSETTELMKEKEILDHLNRKIAE 656
++L+ ++D+ D + ++ EL+ L+ + + T+L + ++ L
Sbjct: 1505 QNKQLRADMEDLMSSKDDVGKNVHELEKSKRALEQQVEEMRTQLEELEDELQATEDAKLR 1564
Query: 657 LEKNIVGEKT---KDADLLDVESKHFEDLEFQQL-EHESRLDEEKENLTQQLLREVAEYQ 712
LE N+ K +D D +++ + L +Q+ E E+ L++E++ R +A
Sbjct: 1565 LEVNMQAMKAQFERDLQTRDEQNEEKKRLLIKQVRELEAELEDERKQ------RALA--- 1615
Query: 713 RNIVSRKEKISALKKQANHIVQQAQREQDHFVKEKNNLIMML---QREKENLCNLEKKYS 769
V+ K+K+ K ++ A + +D +K+ L + QRE E +
Sbjct: 1616 ---VASKKKMEIDLKDLEAQIEAANKARDEVIKQLRKLQAQMKDYQRELEEARASRDEIF 1672
Query: 770 SLSGGKGFPVNPNTLKEGYISVNEINEPCGNSTNLSPSTQFPAD--ADAVATEPA--TAV 825
+ S + LK + ++ E +S + D AD + + +A+
Sbjct: 1673 AQS-----KESEKKLKSLEAEILQLQEELASSERARRHAEQERDELADEITNSASGKSAL 1727
Query: 826 LASQPQSKEHFRSLEERKKQHKEGLYLSDTLPRKKTTSSISPHFSSATMGRSITPKAHLP 885
L + + + LEE ++ + + L + RK T
Sbjct: 1728 LDEKRRLEARIAQLEEELEEEQSNMELLNDRFRKTTL----------------------- 1764
Query: 886 LGQSNSCGSVLPPSLAAMAKDSESRRMLRGYNHQ---QMSEGHRQKSEFYNRTASESNVY 942
Q ++ + L +A K +R+ L N + ++ E + T S
Sbjct: 1765 --QVDTLNAELAAERSAAQKSDNARQQLERQNKELKAKLQELEGAVKSKFKATISALEAK 1822
Query: 943 LNSFHYP-DHSYKDQAFDTLSLDSSDS------METSISACSPDNISSASTSNIARIEEM 995
+ + K++A + ++ M+ D AR++++
Sbjct: 1823 IGQLEEQLEQEAKERAAANKLVRRTEKKLKEIFMQVEDERRHADQYKEQMEKANARMKQL 1882
Query: 996 ERLLKQAHAEKTRLLESR---EREMEAKKRALEEEKRRREILEKRLQ 1039
+R L++A E TR SR +RE++ A E R L+ RL+
Sbjct: 1883 KRQLEEAEEEATRANASRRKLQRELDDATEANEGLSREVSTLKNRLR 1929
Score = 48.1 bits (113), Expect = 5e-05
Identities = 112/586 (19%), Positives = 229/586 (39%), Gaps = 108/586 (18%)
Query: 580 EEQRSQELAAMEETRIVILNNLEELKQKIKDINDQMDESFRELDMECALLD---GEQKSE 636
EE++++ LA + + V++++LEE +K + +++++ R+LD E L E +++
Sbjct: 1018 EEEKAKNLAKIRNKQEVMISDLEERLKKEEKTRQELEKAKRKLDGETTDLQDQIAELQAQ 1077
Query: 637 TTEL-----MKEKE--------------------ILDHLNRKIAELEKNIVGEK------ 665
EL KE+E ++ L +IAEL+++ EK
Sbjct: 1078 IDELKLQLAKKEEELQGALARGDDETLHKNNALKVVRELQAQIAELQEDFESEKASRNKA 1137
Query: 666 -------TKDADLLDVESKHFEDLEFQQLEHESRLDEEKENLTQQLLREVAEYQRNIVSR 718
+++ + L E + D Q E ++ ++E L + L E ++ I
Sbjct: 1138 EKQKRDLSEELEALKTELEDTLDTTAAQQELRTKREQEVAELKKALEEETKNHEAQIQDM 1197
Query: 719 KEKISALKKQANHIVQQAQREQDHFVKEKNNL----------IMMLQREKENLCNLEKK- 767
+++ + ++ + ++QA+R + + K K L + +LQ+ K + KK
Sbjct: 1198 RQRHATALEELSEQLEQAKRFKANLEKNKQGLETDNKELACEVKVLQQVKAESEHKRKKL 1257
Query: 768 -------YSSLSGGKGFPV----NPNTLKEGYISVNEINEP--------CGNSTNLSPST 808
++ +S G V + L+ +V+ + E ++ +L
Sbjct: 1258 DAQVQELHAKVSEGDRLRVELAEKASKLQNELDNVSTLLEEAEKKGIKFAKDAASLESQL 1317
Query: 809 QFPADADAVATEPATAVLASQPQSKEHFRSLEE--------RKKQHKEGLYLSDTL--PR 858
Q + T + + Q +E SL+E RK K+ L L L +
Sbjct: 1318 QDTQELLQEETRQKLNLSSRIRQLEEEKNSLQEQQEEEEEARKNLEKQVLALQSQLADTK 1377
Query: 859 KKTTSSISPHFSSATMGRSITPKAHL---PLGQSNSCGSVLPPSLAAMAKDSESRRMLRG 915
KK + S + + A L + L + + ++ + +
Sbjct: 1378 KKVDDDLGTIESLEEAKKKLLKDAEALSQRLEEKALAYDKLEKTKNRLQQELDDLTVDLD 1437
Query: 916 YNHQQMSEGHRQKSEFYNRTASESNVYLNSFHYPDHSYKDQAFDTLSLDSSDSMETSISA 975
+ Q S +++ +F A E ++ S Y + +D+A +++ E A
Sbjct: 1438 HQRQVASNLEKKQKKFDQLLAEEKSI---SARYAEE--RDRA-------EAEAREKETKA 1485
Query: 976 CSPDNISSASTSNIARIEEMERLLKQAHAEKTRLLESRE------REMEAKKRALEEEKR 1029
S ++ A + EE ER KQ A+ L+ S++ E+E KRALE++
Sbjct: 1486 LS---LARALEEALEAKEEFERQNKQLRADMEDLMSSKDDVGKNVHELEKSKRALEQQV- 1541
Query: 1030 RREILEKRLQEETSQRQKLIEKEVKIRERQRAQARPLTRYLPVRKE 1075
E + +L+E + Q + ++++ +A R L R E
Sbjct: 1542 --EEMRTQLEELEDELQATEDAKLRLEVNMQAMKAQFERDLQTRDE 1585
Score = 47.4 bits (111), Expect = 8e-05
Identities = 73/375 (19%), Positives = 158/375 (42%), Gaps = 39/375 (10%)
Query: 411 ERKSSISSISGRDDLM--DYHRRQREERLREQEMERLERQRLETILSLCAEYTKPDSRLS 468
E+ +++ I + ++M D R ++E QE+E+ +R+ L E T +++
Sbjct: 1020 EKAKNLAKIRNKQEVMISDLEERLKKEEKTRQELEKAKRK-------LDGETTDLQDQIA 1072
Query: 469 TGTTVEDVQKINKELEKLQLSDEESVFEEALMSPDTRYRCHRKDSLPDADLASCGSLSQS 528
++Q EL KLQL+ +E + AL D H+ ++L +++
Sbjct: 1073 ------ELQAQIDEL-KLQLAKKEEELQGALARGDDE-TLHKNNALKVVRELQA-QIAEL 1123
Query: 529 SASFFTPRSTRN----------DELLSDLTRTPPPPSSTFPKASSESSYLSILPKTPEGI 578
F + +++RN +EL + T +T + + + + + +
Sbjct: 1124 QEDFESEKASRNKAEKQKRDLSEELEALKTELEDTLDTTAAQQELRTKREQEVAELKKAL 1183
Query: 579 SEEQRSQE--LAAMEETRIVILNNLEELKQKIKDINDQMDESFRELDMECALLDGEQKSE 636
EE ++ E + M + L L E ++ K ++++ + L+ + + E E
Sbjct: 1184 EEETKNHEAQIQDMRQRHATALEELSEQLEQAKRFKANLEKNKQGLETD----NKELACE 1239
Query: 637 TTELMKEKEILDHLNRKIAELEKNIVGEKTKDADLLDVESKHFEDLEFQQLEHESRLDEE 696
L + K +H +K+ + + + K + D L VE +L++ S L EE
Sbjct: 1240 VKVLQQVKAESEHKRKKL-DAQVQELHAKVSEGDRLRVELAEKASKLQNELDNVSTLLEE 1298
Query: 697 KENLTQQLLREVAEYQRNIVSRKEKISALKKQANHIVQQAQREQDHFVKEKNNLIMMLQR 756
E + ++ A + + +E + +Q ++ + ++ ++ EKN+L +
Sbjct: 1299 AEKKGIKFAKDAASLESQLQDTQELLQEETRQKLNLSSRIRQLEE----EKNSLQEQQEE 1354
Query: 757 EKENLCNLEKKYSSL 771
E+E NLEK+ +L
Sbjct: 1355 EEEARKNLEKQVLAL 1369
Score = 44.7 bits (104), Expect = 5e-04
Identities = 42/190 (22%), Positives = 91/190 (47%), Gaps = 16/190 (8%)
Query: 581 EQRSQELAAMEETRIVILNNLEELKQKIKDINDQMDESFRELDMECALLDGEQKSETTEL 640
+ + +EL ++E + + LEE+++K + + ++ + +L E L E + L
Sbjct: 855 QAKDEELLKVKEKQTKVEGELEEMERKHQQLLEEKNILAEQLQAETELF-AEAEEMRARL 913
Query: 641 MKEKEILDHLNRKIAELEKNIVGEKTKDADLLDVESK---HFEDLEFQQLEHESRLDEEK 697
+K+ L+ + + +LE + E+ ++ L + + K H +DLE Q LDEE
Sbjct: 914 AAKKQELEEI---LHDLESRVEEEEERNQILQNEKKKMQAHIQDLEEQ-------LDEE- 962
Query: 698 ENLTQQLLREVAEYQRNIVSRKEKISALKKQANHIVQQAQREQDHFVKEKNNLIMMLQRE 757
E Q+L E + I +E+I L+ Q + +++ + +D + E ++ + + +
Sbjct: 963 EGARQKLQLEKVTAEAKIKKMEEEILLLEDQNSKFIKEKKLMEDR-IAECSSQLAEEEEK 1021
Query: 758 KENLCNLEKK 767
+NL + K
Sbjct: 1022 AKNLAKIRNK 1031
Score = 38.9 bits (89), Expect = 0.030
Identities = 31/87 (35%), Positives = 43/87 (49%), Gaps = 11/87 (12%)
Query: 984 ASTSNIARIEEMERLL---KQAHAEKTRLLESREREMEAKKRALEEEKRRREI----LEK 1036
A T A EEM L KQ E LESR E E + + L+ EK++ + LE+
Sbjct: 898 AETELFAEAEEMRARLAAKKQELEEILHDLESRVEEEEERNQILQNEKKKMQAHIQDLEE 957
Query: 1037 RLQEETSQRQKL----IEKEVKIRERQ 1059
+L EE RQKL + E KI++ +
Sbjct: 958 QLDEEEGARQKLQLEKVTAEAKIKKME 984
Score = 38.5 bits (88), Expect = 0.039
Identities = 140/771 (18%), Positives = 302/771 (39%), Gaps = 103/771 (13%)
Query: 391 DEADLESLRQASGTP-QPALRERKSSISSISGRDDLMDYHRRQREERLREQEMERLER-Q 448
D D + +Q T + + E K ++ + + RQR E+ E+LE+ +
Sbjct: 1157 DTLDTTAAQQELRTKREQEVAELKKALEEETKNHEAQIQDMRQRHATALEELSEQLEQAK 1216
Query: 449 RLETILSLCAEYTKPDSRLSTGTTVEDVQKINKELEKLQLSDEESVFE-EALMSPDTRYR 507
R + L + + D++ V+ +Q++ E E + + V E A +S R R
Sbjct: 1217 RFKANLEKNKQGLETDNK-ELACEVKVLQQVKAESEHKRKKLDAQVQELHAKVSEGDRLR 1275
Query: 508 CH--RKDSLPDADLASCGSLSQSS----------ASFFTPRSTRNDELLSDLTRTPPPPS 555
K S +L + +L + + A+ + ELL + TR S
Sbjct: 1276 VELAEKASKLQNELDNVSTLLEEAEKKGIKFAKDAASLESQLQDTQELLQEETRQKLNLS 1335
Query: 556 STFPKASSESSYLSILPKTPEGISEEQRSQELAAMEETR---------IVILNNLEELKQ 606
S + E + L + E + Q LA + + + +LEE K+
Sbjct: 1336 SRIRQLEEEKNSLQEQQEEEEEARKNLEKQVLALQSQLADTKKKVDDDLGTIESLEEAKK 1395
Query: 607 K-IKD---INDQMDE---SFRELDMECALLDGEQKSETTELMKEKEILDHLNRK------ 653
K +KD ++ +++E ++ +L+ L E T +L ++++ +L +K
Sbjct: 1396 KLLKDAEALSQRLEEKALAYDKLEKTKNRLQQELDDLTVDLDHQRQVASNLEKKQKKFDQ 1455
Query: 654 -IAELEKNIVGEKTKDADLLDVESKHFEDL----------------EFQQLEHESRLD-- 694
+AE EK+I ++ D + E++ E EF++ + R D
Sbjct: 1456 LLAE-EKSISARYAEERDRAEAEAREKETKALSLARALEEALEAKEEFERQNKQLRADME 1514
Query: 695 -------------EEKENLTQQLLREVAEYQRNIVSRKEKISA-----LKKQANHIVQQA 736
E E + L ++V E + + ++++ A L+ + N +A
Sbjct: 1515 DLMSSKDDVGKNVHELEKSKRALEQQVEEMRTQLEELEDELQATEDAKLRLEVNMQAMKA 1574
Query: 737 QREQDHFVK-----EKNNLIMMLQREKENLCNLEKKYSSL--SGGKGFPVNPNTLKEGYI 789
Q E+D + EK L++ RE E E+K +L + K ++ L+
Sbjct: 1575 QFERDLQTRDEQNEEKKRLLIKQVRELEAELEDERKQRALAVASKKKMEIDLKDLEAQIE 1634
Query: 790 SVNEI-NEPCGNSTNLSPSTQFPADADAVATEPATAVLASQPQSKEHFRSLEERKKQHKE 848
+ N+ +E L + A + A +S++ +SLE Q +E
Sbjct: 1635 AANKARDEVIKQLRKLQAQMKDYQRELEEARASRDEIFAQSKESEKKLKSLEAEILQLQE 1694
Query: 849 GLYLSDTLPR--KKTTSSISPHFSSATMGRSITPKAHLPLGQSNSCGSVLPPSLAAMAKD 906
L S+ R ++ ++ +++ G+S L + L +A + ++
Sbjct: 1695 ELASSERARRHAEQERDELADEITNSASGKSAL------LDEKRR----LEARIAQLEEE 1744
Query: 907 SESRRMLRGYNHQQMSEGHRQKSEFYNRTASESNVYLNSFHYPDHSYKDQAFDTLSLDSS 966
E + N + +++ R+ + + +E ++ D++ + L +
Sbjct: 1745 LEEEQS----NMELLNDRFRKTTLQVDTLNAELAAERSAAQKSDNARQQLERQNKELKAK 1800
Query: 967 -DSMETSISACSPDNISSASTSNIARIEEMERLLKQAHAEKTRLLESREREMEAKKRALE 1025
+E ++ + I SA + I ++EE + A +L+ E++++ +E
Sbjct: 1801 LQELEGAVKSKFKATI-SALEAKIGQLEEQLEQEAKERAAANKLVRRTEKKLKEIFMQVE 1859
Query: 1026 EEKRRREILEKRLQEETSQRQKLIEKEVKIRERQRAQARPLTRYLPVRKED 1076
+E+R + ++++ E+ + R K ++++++ E + +A R L +D
Sbjct: 1860 DERRHADQYKEQM-EKANARMKQLKRQLEEAEEEATRANASRRKLQRELDD 1909
Score = 30.8 bits (68), Expect = 8.2
Identities = 22/83 (26%), Positives = 43/83 (51%), Gaps = 11/83 (13%)
Query: 1013 REREMEAKKRALEEEKRRREILEKRLQEETSQRQKLIEKEVKIRERQR------AQARPL 1066
+E E++AK L + K ++ +E L+E + Q+L+E++ + E+ + A+A +
Sbjct: 850 QEEELQAKDEELLKVKEKQTKVEGELEEMERKHQQLLEEKNILAEQLQAETELFAEAEEM 909
Query: 1067 TRYLPVRKEDF-----DLRSHVE 1084
L +K++ DL S VE
Sbjct: 910 RARLAAKKQELEEILHDLESRVE 932
>gi|6715600 golgi autoantigen, golgin subfamily a, 4 [Homo sapiens]
Length = 2230
Score = 62.0 bits (149), Expect = 3e-09
Identities = 150/717 (20%), Positives = 285/717 (39%), Gaps = 89/717 (12%)
Query: 395 LESLRQASGTPQPALRERKSSISSISGRDDLMDYHRRQREERLREQEMERLERQRLETIL 454
LE+L+Q + L+ K +I S + L+ +E L+EQ ERL Q LE I
Sbjct: 281 LETLQQRVKRQENLLKRCKETIQSHKEQCTLLT----SEKEALQEQLDERL--QELEKIK 334
Query: 455 SL-CAEYTKPDSRLSTGTTVEDVQKINKELEKLQLSDEESVFEEALMSPDTRYRCHRKDS 513
L AE TK ++L D + + ++LE+ ++ ++ +T+ + H
Sbjct: 335 DLHMAEKTKLITQL------RDAKNLIEQLEQ----------DKGMVIAETKRQMHETLE 378
Query: 514 LPDADLASCGSLSQSSASFFTPRSTRNDELLSDLTRTPPPPSSTFPKASSESSYLSILPK 573
+ + ++A S + +T+ +EL ++ KA S + +
Sbjct: 379 MKEEEIAQLRSRIKQM-------TTQGEELREQKEKSERAAFEELEKALSTAQKTEEARR 431
Query: 574 TPEGISEEQRSQELAAMEETRIVILNNLEELKQKIKDINDQMDESFRELDMECALLDGEQ 633
+ +EQ EE RI + L +KQ++ D+ + E + A L Q
Sbjct: 432 KLKAEMDEQIKTIEKTSEEERISLQQELSRVKQEVVDVMKKSSEE------QIAKL---Q 482
Query: 634 KSETTEL-MKEKEILDHLNRKIAELEK--NIVGEKTKDADL-LDVESKHFEDLEFQQLEH 689
K EL KE+E+ L + E ++ + EK++ L + E + E L ++LE
Sbjct: 483 KLHEKELARKEQELTKKLQTREREFQEQMKVALEKSQSEYLKISQEKEQQESLALEELEL 542
Query: 690 ESR-LDEEKENLTQQLLREVAEYQRNIVSRKEKISALKKQANHIVQQAQREQDHFVKEKN 748
+ + + E EN + L +E Y+ I+ E S+L+K Q++ H EKN
Sbjct: 543 QKKAILTESENKLRDLQQEAETYRTRIL---ELESSLEKSLQENKNQSKDLAVHLEAEKN 599
Query: 749 ----NLIMMLQREKENLCNLEKKYSSLSGGKGFPVNPNTLKEGY-ISVNEINEPCGNSTN 803
+ +M+++ K L +L+ + +L + LK+ Y + ++ E C
Sbjct: 600 KHNKEITVMVEKHKTELESLKHQQDAL-----WTEKLQVLKQQYQTEMEKLREKCEQEKE 654
Query: 804 L---SPSTQFPADADAVATEPATAVLASQPQ----SKEHFRSLEERKKQHKEGLYLSDTL 856
F A + + + + Q + S E L+ R K +E L D
Sbjct: 655 TLLKDKEIIFQAHIEEMNEKTLEKLDVKQTELESLSSELSEVLKARHKLEEELSVLKDQT 714
Query: 857 PRKKTTSSISPHFSS---ATMGRSITPKAHLPLGQSNSCGSVLPPSLAAMAKDSESRRML 913
+ K SI + + + ++ L + K+ + + +
Sbjct: 715 DKMKQELEAKMDEQKNHHQQQVDSIIKEHEVSIQRTEKALKDQINQLELLLKERD-KHLK 773
Query: 914 RGYNHQQMSEGHRQKSEFYNRTASES----NVYLNSFHYPDHSYKDQAFD----TLSLDS 965
H + E ++SE + AS Y ++ H +Y++Q L L++
Sbjct: 774 EHQAHVENLEADIKRSEGELQQASAKLDVFQSYQSATHEQTKAYEEQLAQLQQKLLDLET 833
Query: 966 SDSMETSISACSPDNISSASTSNIARIEEMERLLKQAHAEKTRLLESREREMEAKKRALE 1025
+ T A T A +++ L++Q LE + EME K ++L
Sbjct: 834 ERILLTKQVAEVEAQKKDVCTELDAHKIQVQDLMQQ--------LEKQNSEMEQKVKSLT 885
Query: 1026 EEKRRREILEKRLQEETSQRQKLIEKE---VKIRERQRAQARPLTRYLPVRKEDFDL 1079
+ + LE +E+ +Q L+EKE +++RE Q+ + LT+ L +++ +
Sbjct: 886 QVYESK--LEDGNKEQEQTKQILVEKENMILQMREGQKKEIEILTQKLSAKEDSIHI 940
Score = 58.2 bits (139), Expect = 5e-08
Identities = 73/372 (19%), Positives = 161/372 (43%), Gaps = 37/372 (9%)
Query: 409 LRERKSSISSISGRDDLMDYHRRQREERLREQE--MERLERQRLETI--LSLCAEYTKPD 464
++ K+ I S+ + + +++ E+E + +L+++ E I ++L E K +
Sbjct: 1306 IKSMKADIESLVTEKEALQKEGGNQQQAASEKESCITQLKKELSENINAVTLMKEELK-E 1364
Query: 465 SRLSTGTTVEDVQKINKELEK-LQLSDEESVFEEALMSPDTRYRCHRKDSLPDADLASCG 523
++ + + + +N +L+ + LS++E+ D +C D + D
Sbjct: 1365 KKVEISSLSKQLTDLNVQLQNSISLSEKEAAISSLRKQYDEE-KCELLDQVQDLSF-KVD 1422
Query: 524 SLSQSSASFFTPRSTRNDELLSDLTRTPPPPSSTFPKASSESSYLSILPKTPEGISEEQR 583
+LS+ S + D+ + + S F + + L I E +
Sbjct: 1423 TLSKEKISALE----QVDDWSNKFSEWKKKAQSRFTQHQNTVKELQI--------QLELK 1470
Query: 584 SQELAAMEETRIVILNNLEELKQKIKDINDQMDESFRELDMECALLDGEQKSETTELMKE 643
S+E +E ++ L++ ++ + +M++ +++ + + L+ E KS+T +M
Sbjct: 1471 SKEAYEKDEQINLLKEELDQQNKRFDCLKGEMEDDKSKMEKKESNLETELKSQTARIM-- 1528
Query: 644 KEILDHLNRKIAELEKNIVGEKTKDADLL-DVESKHFEDLEFQQLEHESRLDEEKENLTQ 702
E+ DH+ +K E+E + E K+ + D+E K Q+L+H L EEK+N +
Sbjct: 1529 -ELEDHITQKTIEIES--LNEVLKNYNQQKDIEHKEL----VQKLQHFQELGEEKDNRVK 1581
Query: 703 QLLREVAEYQRNIVSRKEKISALKKQANHI---VQQAQRE----QDHFVKEKNNLIMMLQ 755
+ ++ + + S K ++ KK+ H+ V+ + E +D E + L+
Sbjct: 1582 EAEEKILTLENQVYSMKAELETKKKELEHVNLSVKSKEEELKALEDRLESESAAKLAELK 1641
Query: 756 REKENLCNLEKK 767
R+ E KK
Sbjct: 1642 RKAEQKIAAIKK 1653
Score = 49.7 bits (117), Expect = 2e-05
Identities = 107/561 (19%), Positives = 218/561 (38%), Gaps = 76/561 (13%)
Query: 573 KTPEGISEEQRSQELAAMEETRIVILNNLEELKQKIKDINDQMDESFRELDMECALLDGE 632
KT E + +Q EL ++ +L +L++++ + DQ D+ +EL+ +
Sbjct: 674 KTLEKLDVKQT--ELESLSSELSEVLKARHKLEEELSVLKDQTDKMKQELEAKMDEQKNH 731
Query: 633 QKSETTELMKEKEILDHLNRKIAELEKNIVGEKTKDADL-LDVESKHFEDLEFQQLEHES 691
+ + ++KE E+ K + + N + K+ D L H E+LE E
Sbjct: 732 HQQQVDSIIKEHEVSIQRTEKALKDQINQLELLLKERDKHLKEHQAHVENLEADIKRSEG 791
Query: 692 RLDEEKENL-------------TQQLLREVAEYQRNIVSRKEKISALKKQANHIVQQAQR 738
L + L T+ ++A+ Q+ ++ + + L KQ + Q +
Sbjct: 792 ELQQASAKLDVFQSYQSATHEQTKAYEEQLAQLQQKLLDLETERILLTKQVAEVEAQKKD 851
Query: 739 EQDHFVKEKNNLIMMLQREKENLCNLEKKYSSLS---------GGKGFPVNPNTLKEGYI 789
K + ++Q+ ++ +E+K SL+ G K L E
Sbjct: 852 VCTELDAHKIQVQDLMQQLEKQNSEMEQKVKSLTQVYESKLEDGNKEQEQTKQILVEKEN 911
Query: 790 SVNEINEPCGNSTNLSPSTQFPADADAVATEPATAVLASQPQS--KEHFRSLEERKKQHK 847
+ ++ E G + TQ A E + +L + ++ K + +E+ K++ K
Sbjct: 912 MILQMRE--GQKKEIEILTQ-----KLSAKEDSIHILNEEYETKFKNQEKKMEKVKQKAK 964
Query: 848 EGLYLSDTLPRK--KTTSSISPHFSSATMGRSITPKAH----LPLGQSNSCGSVLPPSLA 901
E + +TL +K + + + + S K L + Q+NS G S A
Sbjct: 965 E---MQETLKKKLLDQEAKLKKELENTALELSQKEKQFNAKMLEMAQANSAGI----SDA 1017
Query: 902 AMAKDSESRRMLRGYNHQQMSEGHRQK----SEFYNRTASESNVYLNSFHYPDHSYKDQA 957
++ + + + ++E HR++ + + ++ L H K+Q
Sbjct: 1018 VSRLETNQKEQI-----ESLTEVHRRELNDVISIWEKKLNQQAEELQEIHEIQLQEKEQE 1072
Query: 958 FDTLSLD------SSDSMETSISACSPDNISSASTSNIARIEEMERLLKQAHAEKTRLLE 1011
L + M I+ + + +T N E++ LKQ A L +
Sbjct: 1073 VAELKQKILLFGCEKEEMNKEITWLKEEGVKQDTTLN-----ELQEQLKQKSAHVNSLAQ 1127
Query: 1012 SREREMEAKKRALEEEKRRREILEKRLQEETSQRQKLIEKEVKIRERQRAQARPLTRYLP 1071
E +++A LE + L K L+E T +++L+E ++ + E + + LT L
Sbjct: 1128 D-ETKLKAHLEKLEVD------LNKSLKENTFLQEQLVELKM-LAEEDKRKVSELTSKLK 1179
Query: 1072 VRKEDF-DLRSHVETAGHNID 1091
E+F L+S E + +++
Sbjct: 1180 TTDEEFQSLKSSHEKSNKSLE 1200
Score = 49.7 bits (117), Expect = 2e-05
Identities = 142/670 (21%), Positives = 257/670 (38%), Gaps = 100/670 (14%)
Query: 432 QREERLREQEMERLERQRLETILSLCAEYTKPDSRLSTGTTVEDVQKINKELEKLQLSDE 491
++EE +E + E + +T L+ E K S + +D K+ LEKL++
Sbjct: 1086 EKEEMNKEITWLKEEGVKQDTTLNELQEQLKQKSA-HVNSLAQDETKLKAHLEKLEVDLN 1144
Query: 492 ESVFEEALMSPDTRYRCHRKDSLPDADLASCGSLSQSSASFFTPRSTRNDELLSDL---- 547
+S+ E + +L + S T + DE L
Sbjct: 1145 KSLKENTFLQEQL------------VELKMLAEEDKRKVSELTSKLKTTDEEFQSLKSSH 1192
Query: 548 ---TRTPPPPSSTFPKASSESSY-LSILPKTPEGISEEQRSQELAAMEETRIVILNNLEE 603
++ S F K S E + L I K E + E + ++ + IL+ +
Sbjct: 1193 EKSNKSLEDKSLEFKKLSEELAIQLDICCKKTEALLEAKTNELINISSSKTNAILSRISH 1252
Query: 604 LKQKIKDINDQMDESFRELDMECALLDGEQKSETTELMKEKEILD----HLNRKIAELEK 659
+ + + + + L C + E +++ +L +E+ L+ ++ E E
Sbjct: 1253 CQHRTTKVKEAL------LIKTCTV--SELEAQLRQLTEEQNTLNISFQQATHQLEEKEN 1304
Query: 660 NIVGEKTKDADLLDVESKHFEDLEFQQLE-HESRLDEEKENLTQQLLREVAE-------Y 711
I K D+ES E Q+ ++ + EKE+ QL +E++E
Sbjct: 1305 QIKSMKA------DIESLVTEKEALQKEGGNQQQAASEKESCITQLKKELSENINAVTLM 1358
Query: 712 QRNIVSRKEKISALKKQANHIVQQAQREQDHFVKEKNNLIMMLQRE-KENLCNLEKKYSS 770
+ + +K +IS+L KQ + Q Q + EK I L+++ E C L +
Sbjct: 1359 KEELKEKKVEISSLSKQLTDLNVQLQNSIS--LSEKEAAISSLRKQYDEEKCELLDQVQD 1416
Query: 771 LSGGKGFPVNPNTLKEGYISVNEINEPCGNSTNLSPSTQFPADADAVATEPATAVLASQP 830
LS F V+ TL + IS E + N + ++ A + T+ V Q
Sbjct: 1417 LS----FKVD--TLSKEKISALEQVDDWSNKFS-----EWKKKAQSRFTQHQNTVKELQI 1465
Query: 831 Q----SKEHFRS-------LEERKKQHK-----EGLYLSDTLPRKKTTSSISPHFSSATM 874
Q SKE + EE +Q+K +G D +K S++ S T
Sbjct: 1466 QLELKSKEAYEKDEQINLLKEELDQQNKRFDCLKGEMEDDKSKMEKKESNLETELKSQT- 1524
Query: 875 GRSITPKAHLPLG--QSNSCGSVLPPSLAAMAKDSESRRMLRGYNH-QQMSE--GHRQKS 929
R + + H+ + S VL KD E + +++ H Q++ E +R K
Sbjct: 1525 ARIMELEDHITQKTIEIESLNEVLKNY--NQQKDIEHKELVQKLQHFQELGEEKDNRVKE 1582
Query: 930 EFYNRTASESNVYLNSFHYPDHSYKDQAFDTLSLDSSDSMETSISACSPDNISSASTSNI 989
E+ VY + K + + ++L S S E + A D + S S + +
Sbjct: 1583 AEEKILTLENQVYSMK---AELETKKKELEHVNL-SVKSKEEELKALE-DRLESESAAKL 1637
Query: 990 ARIEEM---------ERLLKQAHAEKTRLLESREREMEAKKRALEEEKRRREILEKRLQE 1040
A ++ ++LL Q ++ + + E + L+E +R ILE++L+
Sbjct: 1638 AELKRKAEQKIAAIKKQLLSQMEEKEEQYKKGTESHLSELNTKLQEREREVHILEEKLKS 1697
Query: 1041 -ETSQRQKLI 1049
E+SQ + LI
Sbjct: 1698 VESSQSETLI 1707
Score = 45.8 bits (107), Expect = 2e-04
Identities = 111/550 (20%), Positives = 209/550 (38%), Gaps = 61/550 (11%)
Query: 578 ISEEQRSQELAAME-----ETRIVILNNLEELKQKIKDINDQMDESFRELDMECALLDGE 632
+S + + +EL A+E E+ + + +QKI I Q+ E + +
Sbjct: 1613 LSVKSKEEELKALEDRLESESAAKLAELKRKAEQKIAAIKKQLLSQMEEKEEQYKKGTES 1672
Query: 633 QKSETTELMKEKEILDH-LNRKIAELEKN-----IVGEKTKDADLLDVESKHFEDLEFQQ 686
SE ++E+E H L K+ +E + IV K+ E + + Q
Sbjct: 1673 HLSELNTKLQEREREVHILEEKLKSVESSQSETLIVPRSAKNVAAY-TEQEEADSQGCVQ 1731
Query: 687 LEHESRLDEEKENLTQQ--LLREVAEYQRNIVSRKEKISALKKQANHIVQQAQREQDHFV 744
+E ++ + NLT++ LL+ V + + VS ++ ++ ++ A+ +Q
Sbjct: 1732 KTYEEKISVLQRNLTEKEKLLQRVGQEKEETVSSHFEMRCQYQERLIKLEHAEAKQH--- 1788
Query: 745 KEKNNLIMMLQREKENLCNLEKKYSSL-------SGGKGFPVNPNTLKEGYISVNEINEP 797
E ++I LQ E E KKYS + GGK L+ + V + +
Sbjct: 1789 -EDQSMIGHLQEELEEK---NKKYSLIVAQHVEKEGGKNNIQAKQNLENVFDDVQKTLQE 1844
Query: 798 CGNSTNLSPSTQFPADADAVATEPATAVLASQPQSK-EHFRSLEERKKQHKEGLYLSDTL 856
+ + D+ V + V + SK E ++L++ ++K L +
Sbjct: 1845 KELTCQILEQKIKELDSCLVRQKEVHRVEMEELTSKYEKLQALQQMDGRNKPTELLEENT 1904
Query: 857 PRKKTTSSISPHFSSATMGRSITPKAHLPLGQSNSCGSVLPPSLAAMAKDSESRRMLRGY 916
K + + P S + + L + L + + KD RMLR
Sbjct: 1905 EEKSKSHLVQPKLLSNMEAQHNDLEFKLAGAEREK--QKLGKEIVRLQKDL---RMLRKE 1959
Query: 917 NHQQMSEGHRQKSEFYNRTASESNVYLNSFHYPDHSYKDQAFDTLSLDSSDSMETSISAC 976
+ Q++ ++ + + L H + F+T +E +I
Sbjct: 1960 HQQELEILKKEYDQEREEKIKQEQEDLELKHNSTLKQLMREFNTQLAQKEQELEMTIK-- 2017
Query: 977 SPDNISSASTSNIARIE----EMERLLKQAHAEK-----------TRLLESREREMEAKK 1021
+ I+ A +E E +LLK+ AEK +L++RE EM AK
Sbjct: 2018 --ETINKAQEVEAELLESHQEETNQLLKKI-AEKDDDLKRTAKRYEEILDAREEEMTAKV 2074
Query: 1022 RALEEEKRRREILEKRLQEETSQRQKLIEKEVKIRERQRAQARPLTRYLPVRKEDFDLRS 1081
R L+ + E L+K+ Q++ Q + V I E Q A+ T + ++ + R
Sbjct: 2075 RDLQTQ---LEELQKKYQQKLEQEENPGNDNVTIMELQTQLAQKTTLISDSKLKEQEFRE 2131
Query: 1082 HVETAGHNID 1091
+ HN++
Sbjct: 2132 QI----HNLE 2137
Score = 44.7 bits (104), Expect = 5e-04
Identities = 44/193 (22%), Positives = 87/193 (45%), Gaps = 19/193 (9%)
Query: 568 LSILPKTPEGISEEQRSQELAAMEETRIVILNNLEELKQKIKDINDQMDESFRELDMEC- 626
L IL K + EE+ QE +E L + LKQ +++ N Q+ + +EL+M
Sbjct: 1964 LEILKKEYDQEREEKIKQEQEDLE------LKHNSTLKQLMREFNTQLAQKEQELEMTIK 2017
Query: 627 ALLDGEQKSETTELMKEKEILDHLNRKIAELEKNIVGEKTKDADLLDVESKHFEDLEFQQ 686
++ Q+ E L +E + L +KIAE + ++ + ++LD E++ +
Sbjct: 2018 ETINKAQEVEAELLESHQEETNQLLKKIAEKDDDLKRTAKRYEEILDARE---EEMTAKV 2074
Query: 687 LEHESRLDEEKENLTQQLLRE---------VAEYQRNIVSRKEKISALKKQANHIVQQAQ 737
+ +++L+E ++ Q+L +E + E Q + + IS K + +Q
Sbjct: 2075 RDLQTQLEELQKKYQQKLEQEENPGNDNVTIMELQTQLAQKTTLISDSKLKEQEFREQIH 2134
Query: 738 REQDHFVKEKNNL 750
+D K + N+
Sbjct: 2135 NLEDRLKKYEKNV 2147
>gi|41281453 serine/threonine kinase 2 [Homo sapiens]
Length = 1235
Score = 60.1 bits (144), Expect = 1e-08
Identities = 78/399 (19%), Positives = 179/399 (44%), Gaps = 57/399 (14%)
Query: 409 LRERKSSISSISGRDDLMDYHRR----QREERLREQEMERLERQRLETILSLCAEYTKPD 464
+ E K+ +I+ +++MD + + EE E +E + S+ A+
Sbjct: 611 IEEGKNKEQAINSSENIMDINEEPGTTEGEEITESSSTEEME------VRSVVAD----T 660
Query: 465 SRLSTGTTVEDVQKINKELEKLQLSDEESVFEEALMSPDTRYRCHRKDSLPDADLAS--- 521
+ + G+ V+D K+ +++K + S+ +E ++ ++ + +P ++ S
Sbjct: 661 DQKALGSEVQDASKVTTQIDKEKKEIPVSIKKEPEVTVVSQPTEPQPVLIPSININSDSG 720
Query: 522 -----CGSLSQSSASFFTPRSTRNDELLSDLTRTPPPPSSTFPKASSESSYLSILPKTPE 576
GSLS++ + P S E +D +S+ S SS+LS K
Sbjct: 721 ENKEEIGSLSKTE-TILPPESENPKENDNDSGTGSTADTSSIDLNLSISSFLS-KTKDSG 778
Query: 577 GISEEQRSQELAAMEETRIVILNNLEELKQKIKDINDQMDESFRELDMECALLDGEQKSE 636
IS ++ ++ +++TR I++ +E K + D D EL L ++ E
Sbjct: 779 SISLQETRRQKKTLKKTRKFIVDGVEVSVTTSKIVTDS-DSKTEEL----RFLRRQELRE 833
Query: 637 TTELMKEKE-ILDHLNRKIAE--------LEKNIVGEKTK-DADLLDVESKHFEDLEFQQ 686
L KE++ LN K+ + E+ ++ +K + D ++ ++E + + +E +
Sbjct: 834 LRFLQKEEQRAQQQLNSKLQQQREQIFRRFEQEMMSKKRQYDQEIENLEKQQKQTIERLE 893
Query: 687 LEHESRLDEEKENLTQQLLREVAEYQRNIVSRKEKI-------------SALKKQANHIV 733
EH +RL +E + + + +E++++Q + +RK+++ +K++ +
Sbjct: 894 QEHTNRLRDEAKRIKGEQEKELSKFQNMLKNRKKEVINEVEKAPKELRKELMKRRKEELA 953
Query: 734 QQAQREQDHFVKEK-----NNLIMMLQREKENLCNLEKK 767
Q ++ FV+++ +L ++Q++K L N+E++
Sbjct: 954 QSQHAQEQEFVQKQQQELDGSLKKIIQQQKAELANIERE 992
Score = 53.1 bits (126), Expect = 2e-06
Identities = 125/620 (20%), Positives = 247/620 (39%), Gaps = 77/620 (12%)
Query: 478 KINKELEKLQLSDEESVFEEALMSPDTRYRCHRKDSLPDADLASC--GSLSQS-----SA 530
++ +E+E + DEE E +L P + K + D +AS LSQ+ S
Sbjct: 310 EVTEEVEDGKEEDEEEETENSLPIPAS------KRASSDLSIASSEEDKLSQNACILESV 363
Query: 531 SFFTPRSTRNDELLSDLTRTPPPPSSTFPKASSESSYLSILPKTPEGISEEQRSQELAAM 590
S T RS D+L S + P K E I+E +L AM
Sbjct: 364 SEKTERSNSEDKLNSKILNEKPTTDEP--------------EKAVEDINEHITDAQLEAM 409
Query: 591 EETR---IVILNNLEELKQKIKDINDQMDESFRELDMECALLDGEQKSETTEL------- 640
E VI N E + K++++ D D+ +++ ++ +G++ + L
Sbjct: 410 TELHDRTAVIKENEREKRPKLENLPDTEDQETVDIN---SVSEGKENNIMITLETNIEHN 466
Query: 641 MKEKEILDHLNRKIAELEKNIVGEKTKDADL--LDVESKHFEDLEFQQLEHESRLDEEKE 698
+K +E D +++ E K I E+ KD L +D+ S+ + E +S + KE
Sbjct: 467 LKSEEEKDQEKQQMFE-NKLIKSEEIKDTILQTVDLVSQETGEKEANIQAVDSEVGLTKE 525
Query: 699 NLTQQLLREVAEYQRNIVSRKEKISALKKQANHIVQQAQREQDHFVKEKNNLIMMLQREK 758
+ TQ+ L E + Q++++S + + A+ + Q+ ++D ++N +
Sbjct: 526 D-TQEKLGEDDKTQKDVISNTSDVIGTCEAAD-VAQKV--DEDSAEDTQSNDGKEVVEVG 581
Query: 759 ENLCNLEKKYSSLSGGKGFPVNPNTLKEGYISVNEINEPCGNSTNLSPSTQFPADADAVA 818
+ L N G K P+ + +NEI E ++ S +
Sbjct: 582 QKLINKPMVGPEAGGTKEVPIKE------IVEMNEIEEGKNKEQAINSSENIMDINEEPG 635
Query: 819 TEPATAVLASQPQSKEHFRSLEERKKQHKEGLYLSDTLPRKKTTSSISPHFSSATMGRSI 878
T + S + RS+ Q G + D K T+ I +
Sbjct: 636 TTEGEEITESSSTEEMEVRSVVADTDQKALGSEVQDA---SKVTTQIDKEKKEIPVSIKK 692
Query: 879 TPKAHLPLGQSNSCGSVLPPSLAAMAKDSESRRMLRGYNHQQM-----SEGHRQKSEFYN 933
P+ + + Q VL PS+ + E++ + + + SE ++
Sbjct: 693 EPEVTV-VSQPTEPQPVLIPSININSDSGENKEEIGSLSKTETILPPESENPKENDNDSG 751
Query: 934 R--TASESNVYLNSFHYPDHSYKDQAFDTLSLDSSDSMETSISACSP---DNIS-SASTS 987
TA S++ LN K + ++SL + + ++ D + S +TS
Sbjct: 752 TGSTADTSSIDLN-LSISSFLSKTKDSGSISLQETRRQKKTLKKTRKFIVDGVEVSVTTS 810
Query: 988 NI-----ARIEEMERLLKQAHAEKTRLLESREREMEAKKRALEEEKRRREILEKRLQEET 1042
I ++ EE+ R L++ + R L+ E+ A+++ + +++RE + +R ++E
Sbjct: 811 KIVTDSDSKTEEL-RFLRRQELRELRFLQKEEQR--AQQQLNSKLQQQREQIFRRFEQEM 867
Query: 1043 SQRQKLIEKEVKIRERQRAQ 1062
+++ ++E++ E+Q+ Q
Sbjct: 868 MSKKRQYDQEIENLEKQQKQ 887
>gi|29788755 SET binding factor 2 [Homo sapiens]
Length = 1849
Score = 59.3 bits (142), Expect = 2e-08
Identities = 56/228 (24%), Positives = 89/228 (39%), Gaps = 18/228 (7%)
Query: 973 ISACSPDNISSASTSNIARIEEMERLLKQAHAEKTRLLESREREMEAKKRALEEEKRRRE 1032
+S PD A TS + IE++E L QA + +L E +++ + R
Sbjct: 1631 VSCTQPD----ALTSLFSEIEKLEHKLNQAPEKWQQLWERVTVDLKEEPRT--------- 1677
Query: 1033 ILEKRLQEETSQRQKLIEKEVKIRERQRAQARPLTRYLPVRKEDFDLRSHVETAGHNIDT 1092
R Q S+ ++ + +++ P + + + VE + +
Sbjct: 1678 ---DRSQRHLSRSPGIVSTNLPSYQKRSLLHLPDSSMGEEQNSSISPSNGVERRAATLYS 1734
Query: 1093 CYHVSITE-KTCRGFLIKMGGKIKTWKKRWFVFDRNKRTFSYYADKHETKLKGVIYFQAI 1151
Y E ++ G L K G +K WK RWFV D K YY +T KG I +
Sbjct: 1735 QYTSKNDENRSFEGTLYKRGALLKGWKPRWFVLDVTKHQLRYYDSGEDTSCKGHIDLAEV 1794
Query: 1152 EEVY-YDHLKNANKSPNPLLTFSVKTHDRIYYMVAPSPEAMRIWMDVI 1198
E V A K + F +KT R+Y A ++ + WMD I
Sbjct: 1795 EMVIPAGPSMGAPKHTSDKAFFDLKTSKRVYNFCAQDGQSAQQWMDKI 1842
>gi|239735519 SET binding factor 1 [Homo sapiens]
Length = 1893
Score = 57.8 bits (138), Expect = 6e-08
Identities = 34/99 (34%), Positives = 48/99 (48%), Gaps = 1/99 (1%)
Query: 1101 KTCRGFLIKMGGKIKTWKKRWFVFDRNKRTFSYYADKHETKLKGVIYFQAIEEVY-YDHL 1159
++ G L K G +K WK RWFV D+ K YY + +T+ KGVI +E V
Sbjct: 1788 RSYEGTLYKKGAFMKPWKARWFVLDKTKHQLRYYDHRVDTECKGVIDLAEVEAVAPGTPT 1847
Query: 1160 KNANKSPNPLLTFSVKTHDRIYYMVAPSPEAMRIWMDVI 1198
A K+ + F VKT R+Y A + + W+D I
Sbjct: 1848 MGAPKTVDEKAFFDVKTTRRVYNFCAQDVPSAQQWVDRI 1886
>gi|22538387 A-kinase anchor protein 9 isoform 2 [Homo sapiens]
Length = 3907
Score = 57.4 bits (137), Expect = 8e-08
Identities = 134/685 (19%), Positives = 267/685 (38%), Gaps = 99/685 (14%)
Query: 422 RDDLMDYHRRQREERLREQEMER-------LERQRLETILSLCAEYTKPDSRLSTGTTVE 474
RDDL Q++ + E ++E LE+++ ++ L + + +L
Sbjct: 2016 RDDL------QKQVKALEIDVEEQVSRFIELEQEKNTELMDLRQQNQALEKQLEKMRKFL 2069
Query: 475 DVQKINKELEKLQLSDEESVFEEAL-----MSPDTRYRCHRKDSLPD---ADLASCGSLS 526
D Q I++E E+ E E+ L P + ++ + L + C L
Sbjct: 2070 DEQAIDREHERDVFQQEIQKLEQQLKVVPRFQPISEHQTREVEQLANHLKEKTDKCSELL 2129
Query: 527 QSSASFFTPRSTRNDEL------LSDLTRTPPPPSSTFPKASSESSYLSILPKTPEGISE 580
S RN+E+ + +L + + TF K + ++ K PE E
Sbjct: 2130 LSKEQLQRDIQERNEEIEKLEFRVRELEQALLVSADTFQKVEDRKHFGAVEAK-PELSLE 2188
Query: 581 EQRSQELAAMEETRIVILNNLEELKQKIKDINDQMDESFRELDMECALLDGEQKSETTEL 640
Q E A++ I NLEE ++ ++ + +E ++L M+ + QK E+T
Sbjct: 2189 VQLQAERDAIDRKEKEI-TNLEEQLEQFREELENKNEEVQQLHMQLEI----QKKESTTR 2243
Query: 641 MKEKEILDHLNRKIAELEKNIVGEKTKDADLLDVESKHFEDLEFQQLEHES-----RLDE 695
++E E + L + ++EK +G K++D + + +H +F Q+ E +L+E
Sbjct: 2244 LQELEQENKLFKD--DMEK--LGLAIKESDAMSTQDQHVLFGKFAQIIQEKEVEIDQLNE 2299
Query: 696 EKENLTQQLLREVAEYQRNIVSRKEKISALKKQANHIVQQAQ---REQDHFVKEKNNLIM 752
+ L QQL ++ + I + E I L+ Q ++ + R ++ +++ N +I
Sbjct: 2300 QVTKLQQQL--KITTDNKVIEEKNELIRDLETQIECLMSDQECVKRNREEEIEQLNEVIE 2357
Query: 753 MLQREKENLCNLEKKYSSLSGGKGFPVNPNTLKEGYISV-NEINEPCGNSTNLSPSTQFP 811
LQ+E N+ G+ +N ++L E S+ ++++ L +
Sbjct: 2358 KLQQELANI------------GQKTSMNAHSLSEEADSLKHQLDVVIAEKLALEQQVETA 2405
Query: 812 ADADAVATEPATAVLASQPQSKEHFRSLEERKKQHKEGLYLSDTLPRKKTTSSISPHFS- 870
+ Q + SL K+ +E + ++P +I H S
Sbjct: 2406 NEEMTFMKNVLKETNFKMNQLTQELFSL----KRERESVEKIQSIPENSVNVAID-HLSK 2460
Query: 871 ---------SATMGRSITPKAHLPLGQSNSCGSV-------LPPSLAAMAKDSESR---R 911
+ +S+ + + + N GS+ L AKD E +
Sbjct: 2461 DKPELEVVLTEDALKSLENQTYFKSFEENGKGSIINLETRLLQLESTVSAKDLELTQCYK 2520
Query: 912 MLRGYNHQQMSEGHRQKSEFYN---------RTASESNVYLNSFHYPDHSYKDQAFDTLS 962
++ Q E + + N A S + L + +++ Q T+S
Sbjct: 2521 QIKDMQEQGQFETEMLQKKIVNLQKIVEEKVAAALVSQIQLEAVQ--EYAKFCQDNQTIS 2578
Query: 963 LDSSDSMETSISACSPDNISSASTSNIARIEEMERLLKQAHAEKTRLLESREREMEAKKR 1022
+ + +++ D + S ++ RI E+E + + H T L+ +E+ A+K
Sbjct: 2579 SEPERTNIQNLNQLREDELGSDISALTLRISELESQVVEMH---TSLILEKEQVEIAEKN 2635
Query: 1023 ALEEEKRRREILEKRLQEETSQRQK 1047
LE+EK+ E+ + E QR+K
Sbjct: 2636 VLEKEKKLLELQKLLEGNEKKQREK 2660
Score = 52.0 bits (123), Expect = 3e-06
Identities = 40/200 (20%), Positives = 97/200 (48%), Gaps = 24/200 (12%)
Query: 580 EEQRSQELAAMEETRIVILNNLEEL--------------KQKIKDINDQMDESFREL--- 622
+E+ +EL + E + + LE+L +Q I + +++E+ + L
Sbjct: 509 KEKLKEELGLILEEKCALQRQLEDLVEELSFSREQIQRARQTIAEQESKLNEAHKSLSTV 568
Query: 623 -DMECALLDGEQKSETTELMKEKEILDH-LNRKIAELEKNIVGEKTKDADLLDVESKHFE 680
D++ ++ + + EL E E+ ++ + ++ E EKN V ++ ++ ++E +
Sbjct: 569 EDLKAEIVSASESRKELELKHEAEVTNYKIKLEMLEKEKNAVLDRMAESQEAELERLRTQ 628
Query: 681 DLEFQQLEHESRLDEEKENLTQQLLREVAEYQRNI-VSRKEKISALKKQANHIVQQAQRE 739
L HE L + KE+L + + + + N+ + K++I L+ + + ++ Q E
Sbjct: 629 LL----FSHEEELSKLKEDLEIEHRINIEKLKDNLGIHYKQQIDGLQNEMSQKIETMQFE 684
Query: 740 QDHFVKEKNNLIMMLQREKE 759
+D+ + ++N LI+ + + K+
Sbjct: 685 KDNLITKQNQLILEISKLKD 704
Score = 50.1 bits (118), Expect = 1e-05
Identities = 124/684 (18%), Positives = 270/684 (39%), Gaps = 134/684 (19%)
Query: 475 DVQKINKELEKLQLS------DEESVFEEALMSPDTRYRCHRKDSLPDADLASCGSLSQS 528
+++++N+ELE+++++ + FE A+ D G ++Q
Sbjct: 170 EIEELNRELEEMRVTYGTEGLQQLQEFEAAIKQRD-------------------GIITQL 210
Query: 529 SASFFTPRSTRNDELLSDLTRTPPPP-----------SSTFPKASSESSYLSILPKTPEG 577
+A+ R +++ + L T S T ++ S+ +L +
Sbjct: 211 TANLQQARREKDETMREFLELTEQSQKLQIQFQQLQASETLRNSTHSSTAADLLQAKQQI 270
Query: 578 ISEEQRSQELAAMEETRIVILNNLEELKQKIKDINDQMDESFRELDMECALLDGEQKSET 637
++ +Q+ +E + LE+ ++K +D Q+ SF + ++ ++ ++K E
Sbjct: 271 LTHQQQLEEQDHL----------LEDYQKKKEDFTMQI--SFLQEKIKVYEMEQDKKVEN 318
Query: 638 T---ELMKEKEILDHLNRKIAELEKNIVGEKTKDADLLDVESKHFEDLEFQQLEHESRLD 694
+ E+ +++ I++ LN KI E EK + K K L K +L+ Q ++ +
Sbjct: 319 SNKEEIQEKETIIEELNTKIIEEEKKTLELKDK----LTTADKLLGELQEQIVQKNQEIK 374
Query: 695 EEKENLT-------------QQLLREVAEYQR----------NIVSRKE-----KISALK 726
K LT +QL+ V E Q+ +IV R E K+ L+
Sbjct: 375 NMKLELTNSKQKERQSSEEIKQLMGTVEELQKRNHKDSQFETDIVQRMEQETQRKLEQLR 434
Query: 727 KQANHIVQQ--AQREQDHFVKEKNNLIMMLQREKENLCNLEKKYSSLSGGKGFPVNPNTL 784
+ + + Q Q +Q+ + + M R K + N + YS+++ VN + +
Sbjct: 435 AELDEMYGQQIVQMKQELIRQHMAQMEEMKTRHKGEMENALRSYSNIT------VNEDQI 488
Query: 785 KEGYISVNEINEPCGNSTNLSPSTQFPADADAVATEPATAVLASQPQSKEHFRSLEE--- 841
K +++NE+N ++ S + + + E + +E S E+
Sbjct: 489 KLMNVAINELNIKLQDTN--SQKEKLKEELGLILEEKCALQRQLEDLVEELSFSREQIQR 546
Query: 842 -RKKQHKEGLYLSDTLPRKKTTSSISPHFSSATMGRSITPKAH----------LPLGQSN 890
R+ ++ L++ T + SA+ R H L + +
Sbjct: 547 ARQTIAEQESKLNEAHKSLSTVEDLKAEIVSASESRKELELKHEAEVTNYKIKLEMLEKE 606
Query: 891 SCGSVLPPSLAAMAKDSESRRMLRGYNHQQMSEGHRQKSEFYNRTASESNVYLNSFHYPD 950
+VL + + E R ++H++ ++ E +R E HY
Sbjct: 607 K-NAVLDRMAESQEAELERLRTQLLFSHEEELSKLKEDLEIEHRINIEKLKDNLGIHYK- 664
Query: 951 HSYKDQAFDTLSLDSSDSMETSISACSPDNISSASTS---NIARIEEMERLLKQAHAEKT 1007
Q D L + S +ET DN+ + I++++++++ L + +E+
Sbjct: 665 -----QQIDGLQNEMSQKIETM--QFEKDNLITKQNQLILEISKLKDLQQSLVNSKSEEM 717
Query: 1008 RL-----------LESREREMEAKKRALEEEKRRREILEKRLQE-ETSQRQKLIEKEVK- 1054
L L E+E ++ ++E + + E+LEK+++E E ++K + E +
Sbjct: 718 TLQINELQKEIEILRQEEKEKGTLEQEVQELQLKTELLEKQMKEKENDLQEKFAQLEAEN 777
Query: 1055 --IRERQRAQARPLTRYLPVRKED 1076
+++ ++ L + PV +E+
Sbjct: 778 SILKDEKKTLEDMLKIHTPVSQEE 801
Score = 45.4 bits (106), Expect = 3e-04
Identities = 98/456 (21%), Positives = 184/456 (40%), Gaps = 86/456 (18%)
Query: 390 FDEADLESLRQASGTPQPALRERKSSISSISGRDDLMDYHRRQREERLRE--QEMERLER 447
+ + + S++Q S +P L ERK+ I++IS DL+ + QRE + + Q E
Sbjct: 2965 YSDGEDHSIQQVS---EPWLEERKAYINTISSLKDLITKMQLQREAEVYDSSQSHESFSD 3021
Query: 448 QRLETILSLCAEYTKPDSRL---------STGTT-------------VEDVQKINKELEK 485
R E +L+L + + S L + GTT E + +E
Sbjct: 3022 WRGELLLALQQVFLEERSVLLAAFRTELTALGTTDAVGLLNCLEQRIQEQGVEYQAAMEC 3081
Query: 486 LQLSDEESVFEE------ALMSPDTRYRCHRKDSLPDADLASCGSLSQSS--------AS 531
LQ +D S+ E + + ++ P +L + S S
Sbjct: 3082 LQKADRRSLLSEIQALHAQMNGRKITLKREQESEKPSQELLEYNIQQKQSQMLEMQVELS 3141
Query: 532 FFTPRSTRND-----------ELLSDLTRTPPPPSSTFPKASS-----ESSYLSILPKTP 575
R+T EL S+L +T +T E+ L + KT
Sbjct: 3142 SMKDRATELQEQLSSEKMVVAELKSELAQTKLELETTLKAQHKHLKELEAFRLEVKDKTD 3201
Query: 576 EG-------ISEEQRSQELA-AMEETRIVILNNLEELKQKIKDINDQMDESFRELDMECA 627
E SE+++S+EL A+E+ + + + E K++++D+ + ES ++ +++
Sbjct: 3202 EVHLLNDTLASEQKKSRELQWALEKEKAKLGRSEERDKEELEDLKFSL-ESQKQRNLQLN 3260
Query: 628 LL---------DGEQKSETTELMKEKEILDHLNRKIAELEKNIVGEKTKDADL---LDVE 675
LL + +QK E+ ++ + ++ + R + EL+ + EK + ++ LD E
Sbjct: 3261 LLLEQQKQLLNESQQKIESQRMLYDAQLSEEQGRNL-ELQVLLESEKVRIREMSSTLDRE 3319
Query: 676 SKHFEDLEFQQLEHESRLDEEKENLTQQLLREVAEYQRNIVSRKEKISALKKQANHIVQQ 735
+ L+ +SR E+L ++L +++ E IV + K + + + +
Sbjct: 3320 RELHAQLQSSDGTGQSRPPLPSEDLLKELQKQLEEKHSRIVELLNETE--KYKLDSLQTR 3377
Query: 736 AQREQDHFVKEKNNLIMMLQREKENLCNLEKKYSSL 771
Q E+D V K LQ E+E +KK L
Sbjct: 3378 QQMEKDRQVHRKT-----LQTEQEANTEGQKKMHEL 3408
Score = 45.1 bits (105), Expect = 4e-04
Identities = 82/387 (21%), Positives = 165/387 (42%), Gaps = 45/387 (11%)
Query: 394 DLESLRQAS--GTPQPALRERKSSISSISGRDDLMDYHRRQREERLREQEMERLERQRLE 451
+LE+L+Q S G + R SS + +G ++ + E+ +E+E++R
Sbjct: 1659 ELEALKQLSLAGREKLCCELRNSSTQTQNGNENQGEVE----EQTFKEKELDRKPEDVPP 1714
Query: 452 TILSLCAEYTKPDSRLSTGTTVEDVQKINKELEKLQLSDEESVFEEALMSPDTRYRCHRK 511
ILS + R + + KI E+ K + EE++ L D +
Sbjct: 1715 EILS--------NERYALQKANNRLLKILLEVVKTTAAVEETIGRHVLGILDRSSKSQSS 1766
Query: 512 DSL-----PDADLASCGSLSQSSASFFTPRSTRNDELLSDLTRTPPPPS--STFPKASSE 564
SL +A + SC + + DE + + + P + + + K + E
Sbjct: 1767 ASLIWRSEAEASVKSCVHEEHTRVT---------DESIPSYSGSDMPRNDINMWSKVTEE 1817
Query: 565 SSYLS--ILPKTPEGISEEQRSQELAAMEETRIVILNNLEELKQKIKDINDQMDESFREL 622
+ LS ++ G + ++EL +R+ +E+L + I + + Q++ + +
Sbjct: 1818 GTELSQRLVRSGFAGTEIDPENEELMLNISSRLQAA--VEKLLEAISETSSQLEHA-KVT 1874
Query: 623 DMECALLDGEQKSETTELMKEKEILDHLNRKIAELEKNIVGEKTKDADLLDV---ESKHF 679
E QK E TE +K +E L + + + + E +K ++D E F
Sbjct: 1875 QTELMRESFRQKQEATESLKCQEELRERLHEESRAREQLAVELSKAEGVIDGYADEKTLF 1934
Query: 680 EDLEFQQLEHESRLDEE---KENLTQQLLREVAEYQ--RNIVSRKEKISALKKQANHIVQ 734
E ++ + RL++E N Q+L E + Q R ++SR+++ A+K +A + Q
Sbjct: 1935 ERQIQEKTDIIDRLEQELLCASNRLQELEAEQQQIQEERELLSRQKE--AMKAEAGPVEQ 1992
Query: 735 QAQREQDHFVKEKNNLIMMLQREKENL 761
Q +E + +KEK + ++ +++L
Sbjct: 1993 QLLQETEKLMKEKLEVQCQAEKVRDDL 2019
Score = 44.7 bits (104), Expect = 5e-04
Identities = 83/414 (20%), Positives = 176/414 (42%), Gaps = 55/414 (13%)
Query: 388 VEFDEADLESLRQASGTPQPALRERKSSISSISG-RDDLMDYHRRQREERLREQ------ 440
+ F ++ RQ + L E S+S++ + +++ ++E L+ +
Sbjct: 537 LSFSREQIQRARQTIAEQESKLNEAHKSLSTVEDLKAEIVSASESRKELELKHEAEVTNY 596
Query: 441 --EMERLERQRLETILSLCAEYTKPD-SRLSTGTTVEDVQKINKELEKLQLSDEESVFEE 497
++E LE+++ +L AE + + RL T ++++K E L++ ++ E+
Sbjct: 597 KIKLEMLEKEK-NAVLDRMAESQEAELERLRTQLLFSHEEELSKLKEDLEIEHRINI-EK 654
Query: 498 ALMSPDTRYRCHRKDSLPDADLASCGSLSQSSASFFTPRSTRNDELLSDLTRTPPPPSST 557
+ Y+ + D L + ++ + T + ++L+ ++++ S
Sbjct: 655 LKDNLGIHYK-QQIDGLQNEMSQKIETMQFEKDNLIT----KQNQLILEISKLKDLQQSL 709
Query: 558 FPKASSESSY-LSILPKTPEGISEEQRSQELAAMEETRIVILNNLEELKQKIKDINDQMD 616
S E + ++ L K E + +E++ + E + + L L++++K+ + +
Sbjct: 710 VNSKSEEMTLQINELQKEIEILRQEEKEKGTLEQEVQELQLKTEL--LEKQMKEKENDLQ 767
Query: 617 ESFRELDMECALLDGEQKSETTELMKEKEILDHLNRKIAELEKNIVGEKTKDADLLDVES 676
E F +L+ E ++L E+K+ +++K ++ +++ E+ I + K V
Sbjct: 768 EKFAQLEAENSILKDEKKT-LEDMLK-------IHTPVSQEERLIFLDSIKSKSKDSVWE 819
Query: 677 KHFEDLEFQQLEHESRLDEEKENLTQQL--LREVAEYQRNIVSRKEKISALKKQANHIVQ 734
K E L EE E+L QQ L E E QRN S EK + N+ Q
Sbjct: 820 KEIE-----------ILIEENEDLKQQCIQLNEEIEKQRNTFSFAEK----NFEVNY--Q 862
Query: 735 QAQREQDHFVKEKNNLIMMLQREKENLCNLEKKYSSLSGGKGF---PVNPNTLK 785
+ Q E +K K++L + +N LE K + + +NP T+K
Sbjct: 863 ELQEEYACLLKVKDDL-----EDSKNKQELEYKSKLKALNEELHLQRINPTTVK 911
Score = 42.7 bits (99), Expect = 0.002
Identities = 59/241 (24%), Positives = 106/241 (43%), Gaps = 46/241 (19%)
Query: 570 ILPKTPEGISEEQRSQELAAMEETRIVILNNLEELKQKIKDINDQMDESFRELDMECALL 629
+L + E + E E ++ET ++ LE Q K + D + + + L+++
Sbjct: 1975 LLSRQKEAMKAEAGPVEQQLLQETEKLMKEKLEVQCQAEK-VRDDLQKQVKALEIDVE-- 2031
Query: 630 DGEQKSETTELMKEK--EILDHLNRKIAELEKNIVGEKTKDADLLDVESKHFEDL---EF 684
EQ S EL +EK E++D L ++ LEK + + K D ++ +H D+ E
Sbjct: 2032 --EQVSRFIELEQEKNTELMD-LRQQNQALEKQLE-KMRKFLDEQAIDREHERDVFQQEI 2087
Query: 685 QQLE--------------HESRLDE-------EKENLTQQLLREVAEYQRNIVSRKEKIS 723
Q+LE H++R E EK + +LL + QR+I R E+I
Sbjct: 2088 QKLEQQLKVVPRFQPISEHQTREVEQLANHLKEKTDKCSELLLSKEQLQRDIQERNEEIE 2147
Query: 724 ALKKQANHIVQ---------QAQREQDHF----VKEKNNLIMMLQREKENLCNLEKKYSS 770
L+ + + Q Q ++ HF K + +L + LQ E++ + EK+ ++
Sbjct: 2148 KLEFRVRELEQALLVSADTFQKVEDRKHFGAVEAKPELSLEVQLQAERDAIDRKEKEITN 2207
Query: 771 L 771
L
Sbjct: 2208 L 2208
Score = 34.7 bits (78), Expect = 0.56
Identities = 71/346 (20%), Positives = 128/346 (36%), Gaps = 77/346 (22%)
Query: 431 RQREERLREQEMERLERQRLETILSLCAEYTKPDSRLSTGTTVEDVQKINKELEKL--QL 488
+Q E LR+ M ++ERQR ED +++ +E+++L QL
Sbjct: 1602 QQATELLRQAHMRQMERQR------------------------EDQEQLQEEIKRLNRQL 1637
Query: 489 SDEESVFEEALMSPDTRYRCHRKDSLPDADLAS----CGSLSQSSASFFTPRSTRNDELL 544
+ S+ E L+S R ++L LA C L SS T N +
Sbjct: 1638 AQRSSIDNENLVSERERVLLEELEALKQLSLAGREKLCCELRNSSTQ--TQNGNENQGEV 1695
Query: 545 SDLTRTPPPPSSTFPKASSESSYLSILPKTPEGISEEQRSQELAAMEETRIVILNNLEEL 604
+ TF + L + PE + E S E A+++ +L L E+
Sbjct: 1696 EE---------QTFKEKE--------LDRKPEDVPPEILSNERYALQKANNRLLKILLEV 1738
Query: 605 KQKIKDINDQMDESFRELDMECALLDGEQKSETTELMKEKEILDHLNRKIAELE-KNIVG 663
+ + + + +LD KS+++ + + R AE K+ V
Sbjct: 1739 VKTTAAVEETIGRHV------LGILDRSSKSQSSASL--------IWRSEAEASVKSCVH 1784
Query: 664 EKTKDADLLDVESKHFEDLEFQQLEHESRLDEEKENLTQQLLR----------EVAEYQR 713
E+ + S D+ + S++ EE L+Q+L+R E E
Sbjct: 1785 EEHTRVTDESIPSYSGSDMPRNDINMWSKVTEEGTELSQRLVRSGFAGTEIDPENEELML 1844
Query: 714 NIVSRKEKISALKKQANHIVQQAQREQDHFVKEKNNLIMMLQREKE 759
NI SR + A ++ + + + +H + L+ R+K+
Sbjct: 1845 NISSR---LQAAVEKLLEAISETSSQLEHAKVTQTELMRESFRQKQ 1887
Score = 34.7 bits (78), Expect = 0.56
Identities = 44/193 (22%), Positives = 73/193 (37%), Gaps = 27/193 (13%)
Query: 591 EETRIVILNNLEELKQKIKDINDQMDESFRELDMECALLDGEQKSETTELMKEKEILDHL 650
E T I LN L E D++ L + + L+ + T L+ EKE ++
Sbjct: 2582 ERTNIQNLNQLRE---------DELGSDISALTLRISELESQVVEMHTSLILEKEQVEIA 2632
Query: 651 NRKIAELEKNIVG-------------EKTKDADLLDVESKHFEDLEFQQLEHESRLDEEK 697
+ + E EK ++ EK K DVE F E ES E
Sbjct: 2633 EKNVLEKEKKLLELQKLLEGNEKKQREKEKKRSPQDVEVLKTTTELFHSNE-ESGFFNEL 2691
Query: 698 ENLTQQLLR---EVAEYQRNIVSRKEKISALKKQANHIVQQAQREQDHFVKEKNNLIMML 754
E L + + E+A Y+ +E++ + + + + +DH + K L +L
Sbjct: 2692 EALRAESVATKAELASYKEKAEKLQEELLVKETNMTSLQKDLSQVRDHLAEAKEKL-SIL 2750
Query: 755 QREKENLCNLEKK 767
++E E KK
Sbjct: 2751 EKEDETEVQESKK 2763
Score = 33.1 bits (74), Expect = 1.6
Identities = 101/519 (19%), Positives = 202/519 (38%), Gaps = 63/519 (12%)
Query: 584 SQELAAMEETRIVILNN-----LEELKQKIKDINDQMDESFRELDMECALLDGEQKSE-- 636
S+EL E + ++L+N + E K + I+++M + + ++ D S
Sbjct: 1518 SKELG--EHGKEILLSNSDPHDIPESKDCVLTISEEMFSKDKTFIVRQSIHDEISVSSMD 1575
Query: 637 -TTELMKEKEILDHLNRKIAELEKNIVGEKTKDADLLDVESKHFEDLEFQQLEHESRLDE 695
+ +LM +E L+ + +++ + E + +LL H +E +Q E + +L E
Sbjct: 1576 ASRQLMLNEEQLEDMRQELVRQYQ----EHQQATELL--RQAHMRQME-RQREDQEQLQE 1628
Query: 696 EKENLTQQLLREVAEYQRNIVSRKEKISALKKQANHIVQQAQREQDHFVKEKNNLIMMLQ 755
E + L +QL + + N+VS +E++ + +A + A RE+ E N Q
Sbjct: 1629 EIKRLNRQLAQRSSIDNENLVSERERVLLEELEALKQLSLAGREK--LCCELRNSSTQTQ 1686
Query: 756 REKENLCNLEK---KYSSLSGGKGFPVNPNTLKEGYISVNEINE------------PCGN 800
EN +E+ K L K V P L ++ + N
Sbjct: 1687 NGNENQGEVEEQTFKEKELD-RKPEDVPPEILSNERYALQKANNRLLKILLEVVKTTAAV 1745
Query: 801 STNLSPSTQFPADADAVATEPATAVLASQPQSKEHFRSLEERKKQHKEGL--YLSDTLPR 858
+ D + + A+ + S+ ++ EE + E + Y +PR
Sbjct: 1746 EETIGRHVLGILDRSSKSQSSASLIWRSEAEASVKSCVHEEHTRVTDESIPSYSGSDMPR 1805
Query: 859 ----------KKTTSSISPHFSSATMGRSITPK-AHLPLGQSNSCGSVLPPSLAAMAKDS 907
++ T S G I P+ L L S+ + + L A+++ S
Sbjct: 1806 NDINMWSKVTEEGTELSQRLVRSGFAGTEIDPENEELMLNISSRLQAAVEKLLEAISETS 1865
Query: 908 ESRRMLRGYNHQQMSEGHRQKSEFYNRTASESNVYLNSFHYPDHSYKDQAFDTLSLDSSD 967
+ + M E RQK E A+ES H + +A + L+++ S
Sbjct: 1866 SQLEHAKVTQTELMRESFRQKQE-----ATESLKCQEELRERLHE-ESRAREQLAVELSK 1919
Query: 968 SMETSISACSPDNISSASTSNIARIEEMERLLKQAHAEKTRLLESREREMEAKKRALEEE 1027
+ D + T +I+E ++ + E +R +E+EA+++ ++EE
Sbjct: 1920 AEGVI------DGYADEKTLFERQIQEKTDIIDRLEQE-LLCASNRLQELEAEQQQIQEE 1972
Query: 1028 KRRREILEKRLQEETS--QRQKLIEKEVKIRERQRAQAR 1064
+ ++ ++ E ++Q L E E ++E+ Q +
Sbjct: 1973 RELLSRQKEAMKAEAGPVEQQLLQETEKLMKEKLEVQCQ 2011
Score = 30.8 bits (68), Expect = 8.2
Identities = 55/260 (21%), Positives = 95/260 (36%), Gaps = 39/260 (15%)
Query: 434 EERLREQEMERLERQRLETILSLCAEYTKPDSRLSTGTTVEDVQKINKELEKLQLSDEES 493
E+ + E+E + LE Q+L K + +DV+ + E ++E
Sbjct: 2633 EKNVLEKEKKLLELQKL------LEGNEKKQREKEKKRSPQDVEVLKTTTELFHSNEESG 2686
Query: 494 VFEEALMSPDTRYRCHRKDSLPD-ADLASCGSLSQSSASFFTPRSTRNDELLSDLTRTPP 552
F E R +S+ A+LAS ++ + T L DL++
Sbjct: 2687 FFNEL--------EALRAESVATKAELASYKEKAEKLQEELLVKETNMTSLQKDLSQVRD 2738
Query: 553 PPSSTFPKASSESSYLSILPKTPEGISEEQRSQELAAMEETRIVILNNLEELKQ---KIK 609
+ K LSIL K E +E Q S++ E I + ++ KI
Sbjct: 2739 HLAEAKEK-------LSILEKEDE--TEVQESKKACMFEPLPIKLSKSIASQTDGTLKIS 2789
Query: 610 DINDQMDESFRELDMECALLDGEQKSETTELMKEKEILDHLNRKIAELEKNIVGEKTKDA 669
N + ++ L E TE I+ KI ++++ A
Sbjct: 2790 SSNQTPQILVKNAGIQINLQSECSSEEVTE------IISQFTEKIEKMQE------LHAA 2837
Query: 670 DLLDVESKHFEDLEFQQLEH 689
++LD+ES+H + E + EH
Sbjct: 2838 EILDMESRHISETETLKREH 2857
>gi|4885583 Rho-associated, coiled-coil containing protein kinase 1
[Homo sapiens]
Length = 1354
Score = 57.0 bits (136), Expect = 1e-07
Identities = 156/771 (20%), Positives = 309/771 (40%), Gaps = 129/771 (16%)
Query: 410 RERKSSISSISGRDDLMDYHRRQREERLREQEMERLERQRLETILSLCAEYTKPDSRLST 469
R ++ +S++ +D L D + + +L +++ +L++Q LE L T+ D+ +
Sbjct: 510 RNVENEVSTL--KDQLEDLKKVSQNSQLANEKLSQLQKQ-LEEANDLLR--TESDTAVRL 564
Query: 470 GTTVEDVQKINKELEKL--QLSDEESVFEEALMSPDTRYRCHRKDSLPDADLASCGSLSQ 527
+ ++ K +LE L +L + + E + D Y ++ ++ +A+ G
Sbjct: 565 RKSHTEMSKSISQLESLNRELQERNRILENSKSQTDKDY--YQLQAILEAERRDRG---- 618
Query: 528 SSASFFTPRSTRNDELLSDLTRTPPPPSSTFPKASSESSYLSILPKTPEGISEEQRSQEL 587
+ E++ DL + E +L + EG E + +Q++
Sbjct: 619 -----------HDSEMIGDL-------QARITSLQEEVKHLKHNLEKVEG--ERKEAQDM 658
Query: 588 AAMEETRIVILNNLE-ELKQKIKDINDQMDESFRELDMECA-LLDGEQKSETTELMKEKE 645
E NNLE +L K+K + ++++ E + A L D Q E + + E
Sbjct: 659 LNHSEKE---KNNLEIDLNYKLKSLQQRLEQEVNEHKVTKARLTDKHQSIEEAKSVAMCE 715
Query: 646 ILDHLN--RKIAELEKNIVGEKTKDADLLDVESKHFEDLEFQQLEH----ESRLDEEKEN 699
+ L R+ E +N V + K +LDV+ K + Q+LEH + R+++E +N
Sbjct: 716 MEKKLKEEREAREKAENRVVQIEKQCSMLDVDLKQSQ----QKLEHLTGNKERMEDEVKN 771
Query: 700 LTQQLLREVAEYQRNIVSRKEKISALKKQANHIVQQAQREQDHFVKEKNNLIMMLQREKE 759
LT QL +E +R ++ + K A + +++ +++ + + E L+ +
Sbjct: 772 LTLQLEQE--SNKRLLLQNELKTQAFEADNLKGLEKQMKQEINTLLEAKRLL------EF 823
Query: 760 NLCNLEKKYSSLSGGKGFPVNPNTLKEGYIS------VNEINEPC--GNSTNLSPSTQFP 811
L L K+Y + G+ + E Y S V E+ E N NL +
Sbjct: 824 ELAQLTKQYRG-NEGQMRELQDQLEAEQYFSTLYKTQVKELKEEIEEKNRENLKKIQELQ 882
Query: 812 ADADAVATEPATAVLASQPQSKEHFRSLEERKKQHKEGLYLSDTLPRKKTTSSISPHFSS 871
+ + +AT+ A ++ +S++ R L E + Y T KK S
Sbjct: 883 NEKETLATQLDLA--ETKAESEQLARGLLEEQ-------YFELTQESKKAAS-------- 925
Query: 872 ATMGRSITPKAHLPLGQSNSCGSVLPPSLAAMAKDSESRRMLRGYNHQQMSEGHRQKSEF 931
+ IT K H S L + + + KD E R +++++E ++ E
Sbjct: 926 -RNRQEITDKDHTV--------SRLEEANSMLTKDIEILRR----ENEELTEKMKKAEEE 972
Query: 932 YNRTASESNVYLNSFHYPDHSYKDQAFDTLSLDSSDSMETSISACSPDNISSASTSNIAR 991
Y E L + AF+ ++++ +++T + + +A
Sbjct: 973 YKLEKEEEISNLKA-----------AFEK-NINTERTLKTQ------------AVNKLAE 1008
Query: 992 IEEMERLLKQAHAEKTRLLESREREMEAKKRALE---EEKRRREILEKRLQEETSQRQKL 1048
I M R + +K + R++E E +K LE E ++ +++ K +E + +L
Sbjct: 1009 I--MNRKDFKIDRKKANTQDLRKKEKENRKLQLELNQEREKFNQMVVKHQKELNDMQAQL 1066
Query: 1049 IEKEVKIRERQRAQARPLTRYLPVRKEDFDLRSHVETAGHNIDTCYHVSITEKTCRGFL- 1107
+E+ E Q A + +R + DL A ++ E G+L
Sbjct: 1067 VEECAHRNELQMQLASKESDIEQLRAKLLDLSDSTSVASFPSADETDGNLPESRIEGWLS 1126
Query: 1108 IKMGGKIKT--WKKRWFVFDRNKRTFSYYADKHETKLKGVIYFQAIEEVYY 1156
+ G IK WKK++ V K F Y D+ + + I+++++
Sbjct: 1127 VPNRGNIKRYGWKKQYVVVSSKKILF--YNDEQDKEQSNPSMVLDIDKLFH 1175
Score = 43.9 bits (102), Expect = 0.001
Identities = 120/630 (19%), Positives = 247/630 (39%), Gaps = 114/630 (18%)
Query: 580 EEQRSQELAAMEETRIVILNNLEELKQKIKDINDQMDESFRELDMECALLDGEQK----S 635
+E + + +EE + +E++QK + N ++D+ +ELD E G Q+ S
Sbjct: 425 QESLQKTIYKLEEQLHNEMQLKDEMEQKCRTSNIKLDKIMKELDEE-----GNQRRNLES 479
Query: 636 ETTELMKEKEILDHLNRKIAELEKNIVGEKTKDADLLDVESKHFEDLE-FQQLEHESRLD 694
+++ KEK +L H +I E ++ E K ++ + S + LE +++ S+L
Sbjct: 480 TVSQIEKEKMLLQH---RINEYQRKAEQENEKRRNVENEVSTLKDQLEDLKKVSQNSQLA 536
Query: 695 EEKENLTQQLLREVAEYQR-----------------NIVSRKEKISALKKQANHIVQ--Q 735
EK + Q+ L E + R +S+ E ++ ++ N I++ +
Sbjct: 537 NEKLSQLQKQLEEANDLLRTESDTAVRLRKSHTEMSKSISQLESLNRELQERNRILENSK 596
Query: 736 AQREQDHF-------------------VKEKNNLIMMLQREKENL-CNLEKKYSSLSGGK 775
+Q ++D++ + + I LQ E ++L NLEK +
Sbjct: 597 SQTDKDYYQLQAILEAERRDRGHDSEMIGDLQARITSLQEEVKHLKHNLEKVEGERKEAQ 656
Query: 776 GFPVNPNTLKEGYISVN--------------EINEPCGNSTNLSPSTQFPADADAVATEP 821
+N + ++ + ++ E+NE L+ Q +A +VA
Sbjct: 657 DM-LNHSEKEKNNLEIDLNYKLKSLQQRLEQEVNEHKVTKARLTDKHQSIEEAKSVAMCE 715
Query: 822 ATAVLASQPQSKEHFRSLEERKKQHKEGLYLSDTLPRKKTTSSISPHFSSATMGRSITPK 881
L + +++E E R Q ++ + D + K++ + +
Sbjct: 716 MEKKLKEEREARE---KAENRVVQIEKQCSMLD-VDLKQSQQKLEHLTGNKERMEDEVKN 771
Query: 882 AHLPLGQSNSCGSVLPPSLAAMAKDSESRRMLRGYNHQQMSEGHRQKSEFYNRTASESNV 941
L L Q ++ +L L A ++++ + L Q+++ K A +
Sbjct: 772 LTLQLEQESNKRLLLQNELKTQAFEADNLKGLEKQMKQEINTLLEAKRLLEFELAQLTKQ 831
Query: 942 YLNS----FHYPDHSYKDQAFDTLSLDSSDSMETSISACSPDNISSASTSNIARIEEMER 997
Y + D +Q F TL ++ + I + N+ +I+E++
Sbjct: 832 YRGNEGQMRELQDQLEAEQYFSTLYKTQVKELK--------EEIEEKNRENLKKIQELQN 883
Query: 998 LLKQAHAEKTRLLESREREMEAKKRALEEE-------------KRRREILEK-----RLQ 1039
K+ A + L E++ + + LEE+ + R+EI +K RL+
Sbjct: 884 -EKETLATQLDLAETKAESEQLARGLLEEQYFELTQESKKAASRNRQEITDKDHTVSRLE 942
Query: 1040 EETSQRQKLIEKEVKIRERQRAQARPLTRYLPVRKEDFDLRSHVETAGHNIDTCYHVSI- 1098
E S ++ K+++I R+ + LT + +E++ L E + N+ + +I
Sbjct: 943 EANS----MLTKDIEILRRENEE---LTEKMKKAEEEYKLEKEEEIS--NLKAAFEKNIN 993
Query: 1099 TEKTCRGFLIKMGGKIKTWKKRWFVFDRNK 1128
TE+T + + +I K F DR K
Sbjct: 994 TERTLKTQAVNKLAEIMNRKD--FKIDRKK 1021
>gi|38044112 restin isoform b [Homo sapiens]
Length = 1392
Score = 56.2 bits (134), Expect = 2e-07
Identities = 113/552 (20%), Positives = 211/552 (38%), Gaps = 75/552 (13%)
Query: 261 RATENQLTPL-SLPPRNSLGNSKRTKL------GEKDLPHSVIDNDNYLNFSSLSSGALP 313
+ATE +L L +L +S G S+ KL EK + H I+ N S + ++
Sbjct: 721 KATEEKLLDLDALRKASSEGKSEMKKLRQQLEAAEKQIKHLEIEK----NAESSKASSI- 775
Query: 314 YKTSASEGNPYVSSTLSVPASPRVARKMLLASTSSCASDDFDQASYVGTNPSHSLLAGES 373
T +G + L S K L + F +AS + S+
Sbjct: 776 --TRELQGRELKLTNLQENLSEVSQVKETLEKELQILKEKFAEASEEAVSVQRSMQE-TV 832
Query: 374 DRVFATRRNFSCGSVEFDEADLESLRQASGTPQPALRERK-----------------SSI 416
+++ F+ S +DLE LR+ + RE+ + I
Sbjct: 833 NKLHQKEEQFNMLS-----SDLEKLRENLADMEAKFREKDEREEQLIKAKEKLENDIAEI 887
Query: 417 SSISGRDDLMDYHRRQREERLREQEMERLERQRLETILSLCAEYTKPDSRLSTGTTVEDV 476
+SG D+ + E RL+E+++E L+ + TK + E+
Sbjct: 888 MKMSG-DNSSQLTKMNDELRLKERDVEELQ-----------LKLTKAN---------ENA 926
Query: 477 QKINKELEKLQLSDEESVFEEALMSPDTRYRCHRKDSLPDADLAS----CGSLSQSSASF 532
+ K +E + + E+S E A + + RK S + + + C L
Sbjct: 927 SFLQKSIEDMTVKAEQSQQEAAKKHEEEKKELERKLSDLEKKMETSHNQCQELKARYERA 986
Query: 533 FTPRSTRNDELLSDLTRTPPPPSSTFPKASSESSYLSILPKTPEGISEEQRSQELAAMEE 592
+ T+++E+L +L +T A E+S +L + E + +++ E+
Sbjct: 987 TSETKTKHEEILQNLQKTLLDTEDKLKGAREENS--GLLQELEELRKQADKAKAAQTAED 1044
Query: 593 TRIVILNNLEELKQKIKDINDQMDESFRELDMECALLDGEQKSETTELMKEKEILDHLNR 652
++ +E + + + D + + L E L EL K KE+L N+
Sbjct: 1045 AMQIMEQMTKEKTETLASLEDTKQTNAK-LQNELDTLKENNLKNVEELNKSKELLTVENQ 1103
Query: 653 KIAELEKNI------VGEKTKDADLLDVES-KHFEDL--EFQQLEHESRLDEEKENLTQQ 703
K+ E K I +K++ L E+ K E+L ++ +L+EE+ L Q
Sbjct: 1104 KMEEFRKEIETLKQAAAQKSQQLSALQEENVKLAEELGRSRDEVTSHQKLEEERSVLNNQ 1163
Query: 704 LLREVAEYQRNIVSRKEKISALKKQANHIVQQAQREQDHFVKEKNNLIMMLQREKENLCN 763
LL + I E+ ++L+K + I E+D +++ N + +L+ E + +
Sbjct: 1164 LLEMKKRESKFIKDADEEKASLQKSIS-ITSALLTEKDAELEKLRNEVTVLRGENASAKS 1222
Query: 764 LEKKYSSLSGGK 775
L +L K
Sbjct: 1223 LHSVVQTLESDK 1234
Score = 50.4 bits (119), Expect = 1e-05
Identities = 202/1068 (18%), Positives = 377/1068 (35%), Gaps = 183/1068 (17%)
Query: 64 QPVPAKRSPSPLGTSVRSSPSLAKIQGSKQFSYDGTDKNIPMKPPTPLLNTTSSLSGYPL 123
Q PA R+ SPL TS S S S T NIP KP P P
Sbjct: 138 QTTPASRATSPLCTSTASMVS----------SSPSTPSNIPQKPSQPAAKE-------PS 180
Query: 124 GRADFDHYTGRDSERALRLSEKPPYSKYSSRHKSHDNVYSLGGLEG----RKASGSLLAM 179
+ T SE LSE K K D V G G +
Sbjct: 181 ATPPISNLTKTASESISNLSEAGSIKKGERELKIGDRVLVGGTKAGVVRFLGETDFAKGE 240
Query: 180 WNGSSLSDA-GPPPISRSGAASMPSSPK--------QARKMSIQDSLALQPKLTRHKELA 230
W G L + G + +G PK + K+ + + K + +
Sbjct: 241 WCGVELDEPLGKNDGAVAGTRYFQCQPKYGLFAPVHKVTKIGFPSTTPAKAKANAVRRVM 300
Query: 231 SENINLRTRKYSSSSLSHMGAYSRSLPRLYRATENQLTPLSLPPRNSLGNSKRTKLGEKD 290
+ R S+SSLS M + + S+ S P R L ++ K
Sbjct: 301 ATTSASLKRSPSASSLSSMSSVASSVS-------------SRPSRTGLLTETSSRYARK- 346
Query: 291 LPHSVIDNDNYLNFSSLSSGALPYKTSASEGNPYVSSTLSVPASPRVARKMLLASTSSCA 350
SG + + E ++ L A + R + +TS
Sbjct: 347 -----------------ISGTTALQEALKEKQQHIEQLL---AERDLERAEVAKATSHVG 386
Query: 351 SDDFDQASYVGTNPSHSL-LAGESDRVFATRRNFSCGSVEFDEADLESLRQASG----TP 405
+ + A + H L L + D++ VE E R+
Sbjct: 387 EIEQELALARDGHDQHVLELEAKMDQLRTMVEAADREKVELLNQLEEEKRKVEDLQFRVE 446
Query: 406 QPALRERKSSISSISGRDDLMDYHRRQREERLREQEMERLERQRLETILSLCAEYTKPDS 465
+ ++ + ++++S + +M+ +++ LR QE+ L R+RLE+ KP
Sbjct: 447 EESITKGDLEVATVSEKSRIMEL---EKDLALRVQEVAEL-RRRLES--------NKPAG 494
Query: 466 RLSTGTTVEDVQKINKELEKLQLSDEESVFEEALMSPD--TRYRCHRKDSLPDADLASCG 523
+ ++ +Q+I+ EKL+++ + E + R H+K+
Sbjct: 495 DVDMSLSL--LQEISSLQEKLEVTRTDHQREITSLKEHFGAREETHQKEI---------- 542
Query: 524 SLSQSSASFFTPRSTRNDELLSDLTRTPPPPSSTFPKASSESSYLSILPKTPEGISEEQR 583
+ T + ++ +E L S A+ E+S + L K+ +
Sbjct: 543 ----KALYTATEKLSKENESLK----------SKLEHANKENSDVIALWKSKLETAIASH 588
Query: 584 SQELAAMEETRIVILNNLEELKQKIKDINDQMDESFRELDMECALLDGEQKSETTELMKE 643
Q AMEE ++ L + ++ Q+++ + E L +Q SE KE
Sbjct: 589 QQ---AMEELKVSFSKGLGTETAEFAELKTQIEKMRLDYQHEIENLQNQQDSERAAHAKE 645
Query: 644 KEILDHLNRKIAELEKNIVG------EKTKDADLLDVES------------KHFEDLEFQ 685
E L K+ + ++N + +K +D L+++E K E L+ +
Sbjct: 646 MEALRAKLMKVIKEKENSLEAIRSKLDKAEDQHLVEMEDTLNKLQEAEIKVKELEVLQAK 705
Query: 686 QLEHESRLDEEKENL--TQQLLREVAEYQRNIVSRKEKISALKKQANHIVQQAQREQDHF 743
E +D L T++ L ++ ++ K ++ L++Q ++ A+++ H
Sbjct: 706 CNEQTKVIDNFTSQLKATEEKLLDLDALRKASSEGKSEMKKLRQQ----LEAAEKQIKHL 761
Query: 744 VKEKN-------NLIMMLQREKENLCNLEKKYSSLSGGKGFPVNPNTLKEGYISVNEINE 796
EKN ++ LQ + L NL++ S +S V KE I + E
Sbjct: 762 EIEKNAESSKASSITRELQGRELKLTNLQENLSEVS-----QVKETLEKELQILKEKFAE 816
Query: 797 PCGNSTNLSPSTQFPADADAVATEPATAVLASQPQSKEH-------FRSLEERKKQ---H 846
+ ++ S Q + E + + + +E+ FR +ER++Q
Sbjct: 817 ASEEAVSVQRSMQETVNKLHQKEEQFNMLSSDLEKLRENLADMEAKFREKDEREEQLIKA 876
Query: 847 KEGLY--LSDTLPRKKTTSS-ISPHFSSATMGRSITPKAHLPLGQSNSCGSVLPPSLAAM 903
KE L +++ + SS ++ + + L L ++N S L S+ M
Sbjct: 877 KEKLENDIAEIMKMSGDNSSQLTKMNDELRLKERDVEELQLKLTKANENASFLQKSIEDM 936
Query: 904 AKDSESRRMLRGYNHQQMSEGHRQKSEFYNRTASESNVYLNSFHYPDHSYKDQAFDTLSL 963
+E + Q+ ++ H ++ + R S+ + + H K + ++ +
Sbjct: 937 TVKAEQ-------SQQEAAKKHEEEKKELERKLSDLEKKMETSHNQCQELKAR-YERATS 988
Query: 964 DSSDSMETSISAC------SPDNISSASTSNIARIEEMERLLKQAHAEKT--------RL 1009
++ E + + D + A N ++E+E L KQA K ++
Sbjct: 989 ETKTKHEEILQNLQKTLLDTEDKLKGAREENSGLLQELEELRKQADKAKAAQTAEDAMQI 1048
Query: 1010 LESREREMEAKKRALEEEKRRREILEKRLQEETSQRQKLIEKEVKIRE 1057
+E +E +LE+ K+ L+ L K +E+ K +E
Sbjct: 1049 MEQMTKEKTETLASLEDTKQTNAKLQNELDTLKENNLKNVEELNKSKE 1096
Score = 39.3 bits (90), Expect = 0.023
Identities = 112/563 (19%), Positives = 224/563 (39%), Gaps = 99/563 (17%)
Query: 578 ISEEQRSQELAAMEETRIVILNNLEELKQKIKDINDQMDESFRELDMECALLDG----EQ 633
+SE+ R EL E+ + + + EL+++++ ++ ++DM +LL ++
Sbjct: 460 VSEKSRIMEL---EKDLALRVQEVAELRRRLES-----NKPAGDVDMSLSLLQEISSLQE 511
Query: 634 KSETTELMKEKEIL---DHLNRKIAELEKNIVGEKTKDADL----------LDVESKHFE 680
K E T ++EI +H + +K I T L L+ +K
Sbjct: 512 KLEVTRTDHQREITSLKEHFGAREETHQKEIKALYTATEKLSKENESLKSKLEHANKENS 571
Query: 681 D--------LEFQQLEHESRLDEEKENLTQQLLREVAEYQRNIVSRKEKISALKKQANHI 732
D LE H+ ++E K + ++ L E AE+ K +I ++ H
Sbjct: 572 DVIALWKSKLETAIASHQQAMEELKVSFSKGLGTETAEF----AELKTQIEKMRLDYQHE 627
Query: 733 VQQAQREQDH----FVKEKNNL---IMMLQREKENLCNLEKKYSSLSGGKGFPV-----N 780
++ Q +QD KE L +M + +EKEN +LE S L + +
Sbjct: 628 IENLQNQQDSERAAHAKEMEALRAKLMKVIKEKEN--SLEAIRSKLDKAEDQHLVEMEDT 685
Query: 781 PNTLKEGYISVNEIN---EPCGNSTNLSPS--TQFPADADAVATEPATAVLASQPQS--K 833
N L+E I V E+ C T + + +Q A + + A +S+ +S K
Sbjct: 686 LNKLQEAEIKVKELEVLQAKCNEQTKVIDNFTSQLKATEEKLLDLDALRKASSEGKSEMK 745
Query: 834 EHFRSLEERKKQHKEGLYLSDTLPRKKTTSSISPHFSSATMGRSIT-PKAHLPLGQSNSC 892
+ + LE +KQ K K SS + + GR + L + +
Sbjct: 746 KLRQQLEAAEKQIKH------LEIEKNAESSKASSITRELQGRELKLTNLQENLSEVSQV 799
Query: 893 GSVLPPSLAAM----AKDSESRRMLRGYNHQQMSEGHRQKSEFYNRTASESNVYLNSFHY 948
L L + A+ SE ++ + +++ H QK E +N +S+ +
Sbjct: 800 KETLEKELQILKEKFAEASEEAVSVQRSMQETVNKLH-QKEEQFNMLSSDLEKLRENLAD 858
Query: 949 PDHSY--KDQAFDTLSLDSSDSMETSISACSPDNISSASTSNIARIEEMERLLKQAHAEK 1006
+ + KD+ + L + + + +E I+ +S ++S + ++ + RL
Sbjct: 859 MEAKFREKDEREEQL-IKAKEKLENDIAEIM--KMSGDNSSQLTKMNDELRL-------- 907
Query: 1007 TRLLESREREMEAKKRALEEEKRRREILEKRLQEETSQRQKLIEKEVKIRERQRAQARPL 1066
+ER++E + L + L+K +++ T + ++ ++ K E ++ +
Sbjct: 908 ------KERDVEELQLKLTKANENASFLQKSIEDMTVKAEQSQQEAAKKHEEEKKE---- 957
Query: 1067 TRYLPVRKEDFDLRSHVETAGHN 1089
+ ++ DL +ET+ HN
Sbjct: 958 -----LERKLSDLEKKMETS-HN 974
Score = 34.3 bits (77), Expect = 0.74
Identities = 27/104 (25%), Positives = 52/104 (50%), Gaps = 24/104 (23%)
Query: 985 STSNIARIEEMERLLKQAHAEKTRLLESR-----------EREMEAKKRALEEEKRRREI 1033
+TS++ IE+ L + H + LE++ +RE LEEEKR+ E
Sbjct: 381 ATSHVGEIEQELALARDGHDQHVLELEAKMDQLRTMVEAADREKVELLNQLEEEKRKVED 440
Query: 1034 LEKRLQEET-----------SQRQKL--IEKEVKIRERQRAQAR 1064
L+ R++EE+ S++ ++ +EK++ +R ++ A+ R
Sbjct: 441 LQFRVEEESITKGDLEVATVSEKSRIMELEKDLALRVQEVAELR 484
>gi|4506751 restin isoform a [Homo sapiens]
Length = 1427
Score = 56.2 bits (134), Expect = 2e-07
Identities = 113/552 (20%), Positives = 211/552 (38%), Gaps = 75/552 (13%)
Query: 261 RATENQLTPL-SLPPRNSLGNSKRTKL------GEKDLPHSVIDNDNYLNFSSLSSGALP 313
+ATE +L L +L +S G S+ KL EK + H I+ N S + ++
Sbjct: 756 KATEEKLLDLDALRKASSEGKSEMKKLRQQLEAAEKQIKHLEIEK----NAESSKASSI- 810
Query: 314 YKTSASEGNPYVSSTLSVPASPRVARKMLLASTSSCASDDFDQASYVGTNPSHSLLAGES 373
T +G + L S K L + F +AS + S+
Sbjct: 811 --TRELQGRELKLTNLQENLSEVSQVKETLEKELQILKEKFAEASEEAVSVQRSMQE-TV 867
Query: 374 DRVFATRRNFSCGSVEFDEADLESLRQASGTPQPALRERK-----------------SSI 416
+++ F+ S +DLE LR+ + RE+ + I
Sbjct: 868 NKLHQKEEQFNMLS-----SDLEKLRENLADMEAKFREKDEREEQLIKAKEKLENDIAEI 922
Query: 417 SSISGRDDLMDYHRRQREERLREQEMERLERQRLETILSLCAEYTKPDSRLSTGTTVEDV 476
+SG D+ + E RL+E+++E L+ + TK + E+
Sbjct: 923 MKMSG-DNSSQLTKMNDELRLKERDVEELQ-----------LKLTKAN---------ENA 961
Query: 477 QKINKELEKLQLSDEESVFEEALMSPDTRYRCHRKDSLPDADLAS----CGSLSQSSASF 532
+ K +E + + E+S E A + + RK S + + + C L
Sbjct: 962 SFLQKSIEDMTVKAEQSQQEAAKKHEEEKKELERKLSDLEKKMETSHNQCQELKARYERA 1021
Query: 533 FTPRSTRNDELLSDLTRTPPPPSSTFPKASSESSYLSILPKTPEGISEEQRSQELAAMEE 592
+ T+++E+L +L +T A E+S +L + E + +++ E+
Sbjct: 1022 TSETKTKHEEILQNLQKTLLDTEDKLKGAREENS--GLLQELEELRKQADKAKAAQTAED 1079
Query: 593 TRIVILNNLEELKQKIKDINDQMDESFRELDMECALLDGEQKSETTELMKEKEILDHLNR 652
++ +E + + + D + + L E L EL K KE+L N+
Sbjct: 1080 AMQIMEQMTKEKTETLASLEDTKQTNAK-LQNELDTLKENNLKNVEELNKSKELLTVENQ 1138
Query: 653 KIAELEKNI------VGEKTKDADLLDVES-KHFEDL--EFQQLEHESRLDEEKENLTQQ 703
K+ E K I +K++ L E+ K E+L ++ +L+EE+ L Q
Sbjct: 1139 KMEEFRKEIETLKQAAAQKSQQLSALQEENVKLAEELGRSRDEVTSHQKLEEERSVLNNQ 1198
Query: 704 LLREVAEYQRNIVSRKEKISALKKQANHIVQQAQREQDHFVKEKNNLIMMLQREKENLCN 763
LL + I E+ ++L+K + I E+D +++ N + +L+ E + +
Sbjct: 1199 LLEMKKRESKFIKDADEEKASLQKSIS-ITSALLTEKDAELEKLRNEVTVLRGENASAKS 1257
Query: 764 LEKKYSSLSGGK 775
L +L K
Sbjct: 1258 LHSVVQTLESDK 1269
Score = 53.5 bits (127), Expect = 1e-06
Identities = 207/1090 (18%), Positives = 379/1090 (34%), Gaps = 192/1090 (17%)
Query: 64 QPVPAKRSPSPLGTSVRSSPSLAKIQGSKQFSYDGTDKNIPMKPPTPLLNTTSSLSGYPL 123
Q PA R+ SPL TS S S S T NIP KP P P
Sbjct: 138 QTTPASRATSPLCTSTASMVS----------SSPSTPSNIPQKPSQPAAKE-------PS 180
Query: 124 GRADFDHYTGRDSERALRLSEKPPYSKYSSRHKSHDNVYSLGGLEG----RKASGSLLAM 179
+ T SE LSE K K D V G G +
Sbjct: 181 ATPPISNLTKTASESISNLSEAGSIKKGERELKIGDRVLVGGTKAGVVRFLGETDFAKGE 240
Query: 180 WNGSSLSDA-GPPPISRSGAASMPSSPK--------QARKMSIQDSLALQPKLTRHKELA 230
W G L + G + +G PK + K+ + + K + +
Sbjct: 241 WCGVELDEPLGKNDGAVAGTRYFQCQPKYGLFAPVHKVTKIGFPSTTPAKAKANAVRRVM 300
Query: 231 SENINLRTRKYSSSSLSHMGAYSRSLPRLYRATENQLTPLSLPPRNSLGNSKRTKLGEKD 290
+ R S+SSLS M + + S+ S P R L ++ K
Sbjct: 301 ATTSASLKRSPSASSLSSMSSVASSVS-------------SRPSRTGLLTETSSRYARK- 346
Query: 291 LPHSVIDNDNYLNFSSLSSGALPYKTSASEGNPYVSSTLSVPASPRVARKMLLASTSSCA 350
SG + + E ++ L A
Sbjct: 347 -----------------ISGTTALQEALKEKQQHIEQLL--------------------A 369
Query: 351 SDDFDQASYVGTNPSHSLLAGESDRVFATRRNFSCGSVEFDEADLESLRQASGTPQPALR 410
D ++A V SH GE ++ A R+ V EA ++ LR + A R
Sbjct: 370 ERDLERAE-VAKATSH---VGEIEQELALARDGHDQHVLELEAKMDQLRTMV---EAADR 422
Query: 411 ERKSSISSISG-RDDLMDYHRRQREERLREQEME---RLERQRLETI-LSLCAEYTKPDS 465
E+ ++ + + + D R EE + + ++E +LE R++ + SL E TK D
Sbjct: 423 EKVELLNQLEEEKRKVEDLQFRVEEESITKGDLETQTKLEHARIKELEQSLLFEKTKAD- 481
Query: 466 RLSTGTTVEDVQKINKELEKLQLSDEESVFEEALMSPDTRYRCHRKDSLPDADLASCGSL 525
+L V ++++ ++L + ++ + + R ++ D L+ +
Sbjct: 482 KLQRELEDTRVATVSEKSRIMELEKDLALRVQEVAELRRRLESNKPAGDVDMSLSLLQEI 541
Query: 526 SQSSASFFTPRSTRNDELLS------------------------DLTRTPPPPSSTFPKA 561
S R+ E+ S L++ S A
Sbjct: 542 SSLQEKLEVTRTDHQREITSLKEHFGAREETHQKEIKALYTATEKLSKENESLKSKLEHA 601
Query: 562 SSESSYLSILPKTPEGISEEQRSQELAAMEETRIVILNNLEELKQKIKDINDQMDESFRE 621
+ E+S + L K+ + Q AMEE ++ L + ++ Q+++ +
Sbjct: 602 NKENSDVIALWKSKLETAIASHQQ---AMEELKVSFSKGLGTETAEFAELKTQIEKMRLD 658
Query: 622 LDMECALLDGEQKSETTELMKEKEILDHLNRKIAELEKNIVG------EKTKDADLLDVE 675
E L +Q SE KE E L K+ + ++N + +K +D L+++E
Sbjct: 659 YQHEIENLQNQQDSERAAHAKEMEALRAKLMKVIKEKENSLEAIRSKLDKAEDQHLVEME 718
Query: 676 S------------KHFEDLEFQQLEHESRLDEEKENL--TQQLLREVAEYQRNIVSRKEK 721
K E L+ + E +D L T++ L ++ ++ K +
Sbjct: 719 DTLNKLQEAEIKVKELEVLQAKCNEQTKVIDNFTSQLKATEEKLLDLDALRKASSEGKSE 778
Query: 722 ISALKKQANHIVQQAQREQDHFVKEKN-------NLIMMLQREKENLCNLEKKYSSLSGG 774
+ L++Q ++ A+++ H EKN ++ LQ + L NL++ S +S
Sbjct: 779 MKKLRQQ----LEAAEKQIKHLEIEKNAESSKASSITRELQGRELKLTNLQENLSEVS-- 832
Query: 775 KGFPVNPNTLKEGYISVNEINEPCGNSTNLSPSTQFPADADAVATEPATAVLASQPQSKE 834
V KE I + E + ++ S Q + E + + + +E
Sbjct: 833 ---QVKETLEKELQILKEKFAEASEEAVSVQRSMQETVNKLHQKEEQFNMLSSDLEKLRE 889
Query: 835 H-------FRSLEERKKQ---HKEGLY--LSDTLPRKKTTSS-ISPHFSSATMGRSITPK 881
+ FR +ER++Q KE L +++ + SS ++ + +
Sbjct: 890 NLADMEAKFREKDEREEQLIKAKEKLENDIAEIMKMSGDNSSQLTKMNDELRLKERDVEE 949
Query: 882 AHLPLGQSNSCGSVLPPSLAAMAKDSESRRMLRGYNHQQMSEGHRQKSEFYNRTASESNV 941
L L ++N S L S+ M +E + Q+ ++ H ++ + R S+
Sbjct: 950 LQLKLTKANENASFLQKSIEDMTVKAEQ-------SQQEAAKKHEEEKKELERKLSDLEK 1002
Query: 942 YLNSFHYPDHSYKDQAFDTLSLDSSDSMETSISAC------SPDNISSASTSNIARIEEM 995
+ + H K + ++ + ++ E + + D + A N ++E+
Sbjct: 1003 KMETSHNQCQELKAR-YERATSETKTKHEEILQNLQKTLLDTEDKLKGAREENSGLLQEL 1061
Query: 996 ERLLKQAHAEKT--------RLLESREREMEAKKRALEEEKRRREILEKRLQEETSQRQK 1047
E L KQA K +++E +E +LE+ K+ L+ L K
Sbjct: 1062 EELRKQADKAKAAQTAEDAMQIMEQMTKEKTETLASLEDTKQTNAKLQNELDTLKENNLK 1121
Query: 1048 LIEKEVKIRE 1057
+E+ K +E
Sbjct: 1122 NVEELNKSKE 1131
Score = 42.4 bits (98), Expect = 0.003
Identities = 141/725 (19%), Positives = 275/725 (37%), Gaps = 94/725 (12%)
Query: 399 RQASGTP--QPALRERKSSISSISGRDDLMDYHRRQREERLRE--QEMERLERQRLETIL 454
R+ SGT Q AL+E++ I + DL + + E QE+ + +L
Sbjct: 345 RKISGTTALQEALKEKQQHIEQLLAERDLERAEVAKATSHVGEIEQELALARDGHDQHVL 404
Query: 455 SLCAEYTKPDSRLSTGTTVEDVQKINKELEKLQLSDEESVFEEALMSPDTRYRCHRKDSL 514
L A+ +L T D +K+ EL QL +E+ E D ++R ++S+
Sbjct: 405 ELEAKM----DQLRTMVEAADREKV--ELLN-QLEEEKRKVE------DLQFRVE-EESI 450
Query: 515 PDADLASCGSLSQSSASFFTP----RSTRNDELLSDLTRTPPPPSSTFPKASSESSYLSI 570
DL + L + T+ D+L +L T S + L++
Sbjct: 451 TKGDLETQTKLEHARIKELEQSLLFEKTKADKLQRELEDTRVATVSEKSRIMELEKDLAL 510
Query: 571 LPKTPEGISEEQRSQELAAMEETRIVILNNLEELKQKIKDINDQMDESFRELDMECALLD 630
+ + S + A + + +L + L++K++ L +
Sbjct: 511 RVQEVAELRRRLESNKPAGDVDMSLSLLQEISSLQEKLEVTRTDHQREITSLKEHFGARE 570
Query: 631 GEQKSETTELMKEKEILDHLNRKIAELEKNIVGEKTKDADLLDVESKHFEDLEFQQLEHE 690
+ E L E L N + ++ E + DV + LE H+
Sbjct: 571 ETHQKEIKALYTATEKLSKENESLKSKLEHANKENS------DVIALWKSKLETAIASHQ 624
Query: 691 SRLDEEKENLTQQLLREVAEYQRNIVSRKEKISALKKQANHIVQQAQREQDH----FVKE 746
++E K + ++ L E AE+ K +I ++ H ++ Q +QD KE
Sbjct: 625 QAMEELKVSFSKGLGTETAEF----AELKTQIEKMRLDYQHEIENLQNQQDSERAAHAKE 680
Query: 747 KNNL---IMMLQREKENLCNLEKKYSSLSGGKGFPV-----NPNTLKEGYISVNEIN--- 795
L +M + +EKEN +LE S L + + N L+E I V E+
Sbjct: 681 MEALRAKLMKVIKEKEN--SLEAIRSKLDKAEDQHLVEMEDTLNKLQEAEIKVKELEVLQ 738
Query: 796 EPCGNSTNLSPS--TQFPADADAVATEPATAVLASQPQS--KEHFRSLEERKKQHKEGLY 851
C T + + +Q A + + A +S+ +S K+ + LE +KQ K
Sbjct: 739 AKCNEQTKVIDNFTSQLKATEEKLLDLDALRKASSEGKSEMKKLRQQLEAAEKQIKH--- 795
Query: 852 LSDTLPRKKTTSSISPHFSSATMGRSIT-PKAHLPLGQSNSCGSVLPPSLAAM----AKD 906
K SS + + GR + L + + L L + A+
Sbjct: 796 ---LEIEKNAESSKASSITRELQGRELKLTNLQENLSEVSQVKETLEKELQILKEKFAEA 852
Query: 907 SESRRMLRGYNHQQMSEGHRQKSEFYNRTASESNVYLNSFHYPDHSY--KDQAFDTLSLD 964
SE ++ + +++ H QK E +N +S+ + + + KD+ + L +
Sbjct: 853 SEEAVSVQRSMQETVNKLH-QKEEQFNMLSSDLEKLRENLADMEAKFREKDEREEQL-IK 910
Query: 965 SSDSMETSISACSPDNISSASTSNIARIEEMERLLKQAHAEKTRLLESREREMEAKKRAL 1024
+ + +E I+ +S ++S + ++ + RL +ER++E + L
Sbjct: 911 AKEKLENDIAEIM--KMSGDNSSQLTKMNDELRL--------------KERDVEELQLKL 954
Query: 1025 EEEKRRREILEKRLQEETSQRQKLIEKEVKIRERQRAQARPLTRYLPVRKEDFDLRSHVE 1084
+ L+K +++ T + ++ ++ K E ++ + + ++ DL +E
Sbjct: 955 TKANENASFLQKSIEDMTVKAEQSQQEAAKKHEEEKKE---------LERKLSDLEKKME 1005
Query: 1085 TAGHN 1089
T+ HN
Sbjct: 1006 TS-HN 1009
>gi|21735548 centrosomal protein 2 [Homo sapiens]
Length = 2442
Score = 55.8 bits (133), Expect = 2e-07
Identities = 133/695 (19%), Positives = 280/695 (40%), Gaps = 112/695 (16%)
Query: 424 DLMDYHRRQR--EERLREQEMERLERQRLETILS------------LCAEYTKPDSRLST 469
+LM+ H + RLR E++R+E Q +L L A + ++ S
Sbjct: 1314 ELMELHETMASLQSRLRRAELQRMEAQGERELLQAAKENLTAQVEHLQAAVVEARAQASA 1373
Query: 470 GTTVEDVQKINKELEKLQLSDEESVFEEALMSPDTRYRCHRKDSLPDADLASCGSLSQSS 529
+E+ + + KL+ + ES R R + +A +L ++
Sbjct: 1374 AGILEEDLRTARSALKLKNEEVES----------ERERAQALQEQGELKVAQGKALQENL 1423
Query: 530 ASFFTPRSTRNDEL------LSDLTRTPPPPSSTFPKASSESSYLSILPKTPEGISEEQR 583
A + R +E+ + +L + KA+ E L + + E ++++
Sbjct: 1424 ALLTQTLAEREEEVETLRGQIQELEK-----QREMQKAALELLSLDLKKRNQEVDLQQEQ 1478
Query: 584 SQELAAMEETRIVILNNLEELKQKIKDINDQMD---ESFRELDMECALLDGEQKSETTEL 640
QEL E+ R V LE L +++ ++ E REL+ + + + EL
Sbjct: 1479 IQEL---EKCRSV----LEHLPMAVQEREQKLTVQREQIRELEKDRETQRNVLEHQLLEL 1531
Query: 641 MKEKEILDHLNRKIAELEKNIVGEKTKDADLLDVESKHFEDLEFQQL---EHESRLDEEK 697
K+ ++++ ++ +L+K +V T + L++E H + +E QQ E E + + ++
Sbjct: 1532 EKKDQMIESQRGQVQDLKKQLV---TLECLALELEENHHK-MECQQKLIKELEGQRETQR 1587
Query: 698 ENLTQQLLREVAEYQRNIVSRKEKISALKKQANHIVQQAQREQDHFVKEKNNLIMMLQRE 757
LT L ++ E + + ++ +I L+ + + ++ Q E+D VK + I LQR+
Sbjct: 1588 VALTHLTL-DLEERSQELQAQSSQIHDLESHSTVLARELQ-ERDQEVKSQREQIEELQRQ 1645
Query: 758 KENLC-NLEKKYSSL------------SGGKGFPVNPNTLKEGYISVNEINEPCGNSTNL 804
KE+L +LE++ L + + L++ +S+ E L
Sbjct: 1646 KEHLTQDLERRDQELMLQKERIQVLEDQRTRQTKILEEDLEQIKLSLRERGRELTTQRQL 1705
Query: 805 ----SPSTQFPADADAVATEPATAVLASQPQ----SKEHFRSLEERKKQHKEGLYLSDTL 856
+ + P+ A + E +L + + +EH L+E K Q ++ L L
Sbjct: 1706 MQERAEEGKGPSKAQRGSLEHMKLILRDKEKEVECQQEHIHELQELKDQLEQQL---QGL 1762
Query: 857 PRKKTTSSI---SPHFSSATMGRSITPKAHLPLGQSNSCGSVLPPSLAAMAKDSESRRML 913
RK +S+ + + + + S S L + A+A+ + L
Sbjct: 1763 HRKVGETSLLLSQREQEIVVLQQQLQEAREQGELKEQSLQSQLDEAQRALAQRDQELEAL 1822
Query: 914 RGYNHQQMSEGH----RQKSEFYNRTASESNVYLNSFHYPDHSYKDQAFDTLSLDSSDSM 969
+ QQ ++G ++K++ ++++ L H +K+QA L+ ++
Sbjct: 1823 Q--QEQQQAQGQEERVKEKADALQGALEQAHMTLKERHGELQDHKEQA---RRLEEELAV 1877
Query: 970 ETSISACSPDNISSASTSNIARIEEMERLLKQAHAEKTRLLESREREMEAKKRALEEEKR 1029
E R++ +E +L AE +E+ + A ++ E+ +
Sbjct: 1878 EG------------------RRVQALEEVLGDLRAES----REQEKALLALQQQCAEQAQ 1915
Query: 1030 RREILEKRLQEETSQRQKLIEKEVKIRERQRAQAR 1064
E+ + LQ+ Q Q ++++ + E RA+++
Sbjct: 1916 EHEVETRALQDSWLQAQAVLKERDQELEALRAESQ 1950
Score = 47.4 bits (111), Expect = 8e-05
Identities = 160/762 (20%), Positives = 295/762 (38%), Gaps = 129/762 (16%)
Query: 380 RRNFSCGSVEFDEADLESLRQASGTPQPALRERKSSIS-------SISGRDDLMDYHRRQ 432
+R ++E DL+ Q Q ++E + S ++ R+ + R Q
Sbjct: 1450 QREMQKAALELLSLDLKKRNQEVDLQQEQIQELEKCRSVLEHLPMAVQEREQKLTVQREQ 1509
Query: 433 REERLREQEMER--LERQRLETILSLCAEYTKPDSRL-STGTTVEDVQKINKELEKLQLS 489
E +++E +R LE Q LE K D + S V+D++K LE L L
Sbjct: 1510 IRELEKDRETQRNVLEHQLLEL--------EKKDQMIESQRGQVQDLKKQLVTLECLALE 1561
Query: 490 DEESVF----EEALMSPDTRYRCHRKDSLPDADLASCGSLSQSSASFFTPRSTRNDELLS 545
EE+ ++ L+ R ++ +L L L + S +S++ +L S
Sbjct: 1562 LEENHHKMECQQKLIKELEGQRETQRVALTHLTL----DLEERSQEL-QAQSSQIHDLES 1616
Query: 546 DLTRTPPPPSSTFPKASSESSYLSILPKTPEGISE--EQRSQELAAMEETRIVILNNLEE 603
T + S+ + L + E +++ E+R QEL +E RI +L +
Sbjct: 1617 HSTVLARELQERDQEVKSQREQIEELQRQKEHLTQDLERRDQELMLQKE-RIQVLEDQRT 1675
Query: 604 LKQKIKDIN-DQMDESFRELDMECALLDGEQKSETTELMKEKEILDHLNRKIAELEKNIV 662
+ KI + + +Q+ S RE E Q+ E +E + R E K I+
Sbjct: 1676 RQTKILEEDLEQIKLSLRERGRELTT----QRQLMQERAEEGKGPSKAQRGSLEHMKLIL 1731
Query: 663 GEKTKDADLLDVESKHFEDLEFQQLEHESRLDEEKENLTQQLL---REVAEYQRNIVSRK 719
+K K+ + Q EH L E K+ L QQL R+V E + R+
Sbjct: 1732 RDKEKEVEC--------------QQEHIHELQELKDQLEQQLQGLHRKVGETSLLLSQRE 1777
Query: 720 EKISALKKQANHIVQQAQREQDHFVKEKNNLIMMLQREKENLCNLEKKYSSLSGGKGFPV 779
++I L++Q +Q + ++ + + L + + L L+++ G +
Sbjct: 1778 QEIVVLQQQLQEAREQGELKEQSLQSQLDEAQRALAQRDQELEALQQEQQQAQGQE---- 1833
Query: 780 NPNTLKEGYISVNEINEPCGNSTNLSPSTQFPADADAVATEPATAVLASQ----PQSKEH 835
+KE ADA A E A L + KE
Sbjct: 1834 --ERVKE------------------------KADALQGALEQAHMTLKERHGELQDHKEQ 1867
Query: 836 FRSLEE------RKKQHKE---GLYLSDTLPRKKTTSSISPHFSSATMGRSITPKAHLPL 886
R LEE R+ Q E G +++ ++K ++ + + +A
Sbjct: 1868 ARRLEEELAVEGRRVQALEEVLGDLRAESREQEKALLALQQQCAEQAQEHEVETRALQDS 1927
Query: 887 G-QSNSCGSVLPPSLAAMAKDSESRRMLRGYNHQQMSEGHRQKSEFYNRTASESNVYLNS 945
Q+ + L A+ +S+S R HQ+ E R ++E +++ L
Sbjct: 1928 WLQAQAVLKERDQELEALRAESQSSR------HQE--EAARARAEALQEALGKAHAALQG 1979
Query: 946 FHYPDHSYKDQAFDTLSLDSSDS-METSISACSPDNISSASTSNIA---------RIEEM 995
+ +QA + SL++S + ++ S+ AC + I R +E
Sbjct: 1980 ---KEQHLLEQAELSRSLEASTATLQASLDACQAHSRQLEEALRIQEGEIQDQDLRYQED 2036
Query: 996 ERLLKQAHAEKTRLLESREREMEAKKRALEEEKRRREILEKRLQEETSQRQKLIEKEVK- 1054
+ L+QA A++ L R + +++ LE+ +R + E +QE+ + Q+ E+E++
Sbjct: 2037 VQQLQQALAQRDEEL----RHQQEREQLLEKSLAQR-VQENMIQEKQNLGQEREEEEIRG 2091
Query: 1055 ----IRERQRAQARPLTRYLPVRKEDFDLRSHVETAGHNIDT 1092
+RE Q A+ L +R + R+++E H+ T
Sbjct: 2092 LHQSVRELQLTLAQKEQEILELR--ETQQRNNLEALPHSHKT 2131
Score = 46.2 bits (108), Expect = 2e-04
Identities = 147/723 (20%), Positives = 277/723 (38%), Gaps = 126/723 (17%)
Query: 395 LESLRQASGTPQPALRERKSSISSISGRDDLMDYHRRQREERLREQEMERLERQR---LE 451
LESL + + L+E+++ + +I + + R Q E L + ++E E++R LE
Sbjct: 877 LESLEREKMELEMRLKEQQTEMEAIQAQ---REEERTQAESALCQMQLET-EKERVSLLE 932
Query: 452 TILSLCAEYTKPDSRLSTGTTVEDVQKINKE----LEKLQLSDEESVFEEALMSPDTRYR 507
T+L E +L VQK+ ++ + + QL + + +EA R
Sbjct: 933 TLLQTQKELADASQQLERLRQDMKVQKLKEQETTGILQTQLQEAQRELKEAA-------R 985
Query: 508 CHRKDSLPDADLASCGSLSQSSASFFTPR---STRNDELLSDLTRTPPPPSSTFPKASSE 564
HR D +L + S+S + + ++L S L + +
Sbjct: 986 QHRDD---------LAALQEESSSLLQDKMDLQKQVEDLKSQLVAQDDSQRLVEQEVQEK 1036
Query: 565 SSYLSILPKTPEGISEEQRSQELAAME-ETRIVILNNLEELKQK-IKDINDQMDESFREL 622
+ + + E+ S L+ ME E R+++L + ++Q+ + + M E+
Sbjct: 1037 LRETQEYNRIQKELEREKASLTLSLMEKEQRLLVLQEADSIRQQELSALRQDMQEA---- 1092
Query: 623 DMECALLDGEQKSETTELMKEKEILDHLNRKIAELEKNIVGEKTKDADLLDVESKHFEDL 682
GEQK EL + E+L K K+AD L E++ E+L
Sbjct: 1093 -------QGEQK----ELSAQMELLRQ-------------EVKEKEADFLAQEAQLLEEL 1128
Query: 683 EFQQLEHE---SRLDEEKENLTQQLLREVAEYQRNIVSRKEKISALKKQANHIVQQAQRE 739
E + + + L ++ Q LR R+ S+ E ++A ++ N QAQ
Sbjct: 1129 EASHITEQQLRASLWAQEAKAAQLQLR-----LRSTESQLEALAAEQQPGNQAQAQAQLA 1183
Query: 740 QDHFVKEKNNLIMMLQREKENLCNLEKKYSSLSGGKGFPVNPNTLKEGYISVNEINEPCG 799
+L LQ+ ++C + S GG P SV +
Sbjct: 1184 ---------SLYSALQQALGSVCESRPELS--GGGDSAP-----------SVWGLEPDQN 1221
Query: 800 NSTNLSPS----TQFPADADAVATEPATAVLASQPQSKEHFRSLEERKKQHKEGLYLSDT 855
+ +L T A+A A A L Q+++ R ++ ++ L+DT
Sbjct: 1222 GARSLFKRGPLLTALSAEAVASALHKLHQDLWKTQQTRDVLRDQVQKLEER-----LTDT 1276
Query: 856 LPRKKTTSSISPHFSSATMGRSITPKAHLPL---GQSNSCGSVLPPSLAAMAKDSESRRM 912
K H + R ++ G+ NS S L MA S R+
Sbjct: 1277 EAEKSQV-----HTELQDLQRQLSQNQEEKSKWEGKQNSLESELMELHETMA--SLQSRL 1329
Query: 913 LRGYNHQQMSEGHRQKSEFYNRTASESNVYLNSFHYPDHSYKDQAFDTLSLDSSDSMETS 972
R + ++G R+ + A++ N+ H + +A + + + + T+
Sbjct: 1330 RRAELQRMEAQGERELLQ-----AAKENLTAQVEHLQAAVVEARAQASAAGILEEDLRTA 1384
Query: 973 ISACSPDNISSASTSNIARIEEMERLLKQAHAEK--------TRLLESREREMEAKKRAL 1024
SA N S A+ + + LK A + T+ L RE E+E + +
Sbjct: 1385 RSALKLKNEEVESERERAQALQEQGELKVAQGKALQENLALLTQTLAEREEEVETLRGQI 1444
Query: 1025 EEEKRRREILEKRLQEETSQRQKLIEKEVKIRERQ---RAQARPLTRYLPVRKEDFDLRS 1081
+E +++RE ++K E S K +EV +++ Q + R + +LP+ ++ + +
Sbjct: 1445 QELEKQRE-MQKAALELLSLDLKKRNQEVDLQQEQIQELEKCRSVLEHLPMAVQEREQKL 1503
Query: 1082 HVE 1084
V+
Sbjct: 1504 TVQ 1506
Score = 45.4 bits (106), Expect = 3e-04
Identities = 90/529 (17%), Positives = 214/529 (40%), Gaps = 57/529 (10%)
Query: 580 EEQRSQELAAMEETRIVILNNLEELKQKIKDINDQMDESFRELDMECALLDGEQKSETTE 639
+++ ++ L ++E ++ + L+E + +++ I Q +E + + + E + E
Sbjct: 870 QQELAKALESLEREKMELEMRLKEQQTEMEAIQAQREEERTQAESALCQMQLETEKERVS 929
Query: 640 LMK-----EKEILDHLNRKIAELEKNIVGEKTKDADLLDVESKHFEDLEFQQLEHESRLD 694
L++ +KE+ D ++++ L +++ +K K+ + + ++ + + E +
Sbjct: 930 LLETLLQTQKELAD-ASQQLERLRQDMKVQKLKEQETTGILQTQLQEAQRELKEAARQHR 988
Query: 695 EEKENLTQQ---LLREVAEYQRNIVSRKEKISALKKQANHIVQQAQREQDHFVKEKNNLI 751
++ L ++ LL++ + Q+ + K ++ A + + +V+Q +E+ +E N +
Sbjct: 989 DDLAALQEESSSLLQDKMDLQKQVEDLKSQLVA-QDDSQRLVEQEVQEKLRETQEYNRIQ 1047
Query: 752 MMLQREKEN--LCNLEKKYSSLSGGKGFPVNPNTLKEGYISVNEINEPCGNSTNLSPSTQ 809
L+REK + L +EK+ L + + L ++ E G LS +
Sbjct: 1048 KELEREKASLTLSLMEKEQRLLVLQEADSIRQQELS---ALRQDMQEAQGEQKELSAQME 1104
Query: 810 FPADADAVATEPATAVLASQPQSKEHFRSLEERKKQHKEGLYLSDT------LPRKKTTS 863
E LA + Q E + ++Q + L+ + L + T S
Sbjct: 1105 LLRQE---VKEKEADFLAQEAQLLEELEASHITEQQLRASLWAQEAKAAQLQLRLRSTES 1161
Query: 864 SISPHFSSATMGRSITPKAHLPLGQSNSCGSVLPPSLAAMAKDSESRRMLRGYNHQQMSE 923
+ + G +A L S S L +L ++ ESR L G S
Sbjct: 1162 QLEALAAEQQPGNQAQAQAQLA-----SLYSALQQALGSVC---ESRPELSGGGDSAPSV 1213
Query: 924 GHRQKSEFYNRTASESNVYLNSFHYPDHSYKDQAFDTLSLDSSDSMETSISACSPDNISS 983
+ + R+ + L + S++++ +++ D +
Sbjct: 1214 WGLEPDQNGARSLFKRGPLLTAL------------------SAEAVASALHKLHQDLWKT 1255
Query: 984 ASTSNIAR--IEEMERLLKQAHAEKTRL---LESREREMEAKKRALEEEKRRREILEKRL 1038
T ++ R ++++E L AEK+++ L+ +R++ + + + ++ LE L
Sbjct: 1256 QQTRDVLRDQVQKLEERLTDTEAEKSQVHTELQDLQRQLSQNQEEKSKWEGKQNSLESEL 1315
Query: 1039 QEETSQRQKLIEKEVKIRERQRAQARPLTRYLPVRKEDFDLR-SHVETA 1086
E + ++ ++ E QR +A+ L KE+ + H++ A
Sbjct: 1316 M-ELHETMASLQSRLRRAELQRMEAQGERELLQAAKENLTAQVEHLQAA 1363
Score = 43.1 bits (100), Expect = 0.002
Identities = 127/703 (18%), Positives = 262/703 (37%), Gaps = 74/703 (10%)
Query: 417 SSISGRDDLMDYHRRQREERLRE-QEMERLERQRLETILSLCAEYTKPDSRLSTGTTVED 475
S + +DD ++ +E+LRE QE R++++ SL + + RL +
Sbjct: 1017 SQLVAQDDSQRLVEQEVQEKLRETQEYNRIQKELEREKASLTLSLMEKEQRLLVLQEADS 1076
Query: 476 VQKINKELEKLQLSDEESVFEEALMSPDTRY-RCHRKDSLPDADLASCGSLSQSSASFFT 534
+++ +EL L+ +E+ E+ +S R K+ D L + AS T
Sbjct: 1077 IRQ--QELSALRQDMQEAQGEQKELSAQMELLRQEVKEKEADFLAQEAQLLEELEASHIT 1134
Query: 535 PRSTRNDELLSDLTRTPPPPSSTFPKASSESSYLSILPKTPEGISEEQRSQELAAMEETR 594
+ R + L + + S S L L + ++ Q +LA++
Sbjct: 1135 EQQLR-----ASLWAQEAKAAQLQLRLRSTESQLEALAAEQQPGNQAQAQAQLASLYSAL 1189
Query: 595 IVILNNLEELKQKIKDINDQMDESF---------RELDMECALLDGEQKSETT------- 638
L ++ E + ++ D + R L LL
Sbjct: 1190 QQALGSVCESRPELSGGGDSAPSVWGLEPDQNGARSLFKRGPLLTALSAEAVASALHKLH 1249
Query: 639 -ELMKEKEILDHLNRKIAELEKNIVGEKTKDADLLDVESKHFEDLEFQ--QLEHESRLDE 695
+L K ++ D L ++ +LE+ + + + + + +DL+ Q Q + E E
Sbjct: 1250 QDLWKTQQTRDVLRDQVQKLEERLTDTEAEKSQV----HTELQDLQRQLSQNQEEKSKWE 1305
Query: 696 EKENLTQQLLREVAEYQRNIVSRKEKISALKKQANHIVQQAQREQDHFVKEKNNLIMMLQ 755
K+N + L E+ E ++ SR + + +A Q +RE KE + Q
Sbjct: 1306 GKQNSLESELMELHETMASLQSRLRRAELQRMEA-----QGERELLQAAKEN----LTAQ 1356
Query: 756 REKENLCNLEKKYSSLSGGKGFPVNPNTLKEGYISVNEINEPCGNSTNLSPSTQFPAD-- 813
E +E + + + G + L+ ++ NE + + + Q +
Sbjct: 1357 VEHLQAAVVEARAQASAAG----ILEEDLRTARSALKLKNEEVESERERAQALQEQGELK 1412
Query: 814 -ADAVATEPATAVLASQPQSKEH--------FRSLEERKKQHKEGLYLS--DTLPRKKTT 862
A A + A+L +E + LE++++ K L L D R +
Sbjct: 1413 VAQGKALQENLALLTQTLAEREEEVETLRGQIQELEKQREMQKAALELLSLDLKKRNQEV 1472
Query: 863 SSISPHFSSATMGRSITPKAHLPLGQSNSCGSVLPPSLAAMAKDSESRR------MLRGY 916
RS+ + + + +V + + KD E++R +L
Sbjct: 1473 DLQQEQIQELEKCRSVLEHLPMAVQEREQKLTVQREQIRELEKDRETQRNVLEHQLLELE 1532
Query: 917 NHQQMSEGHRQKSEFYNRTASESNVYLNSFHYPDHSYKDQAFDTLSLDSSDSMETSISAC 976
QM E Q+ + + + + ++ +K + L + ET A
Sbjct: 1533 KKDQMIES--QRGQVQDLKKQLVTLECLALELEENHHKMECQQKLIKELEGQRETQRVAL 1590
Query: 977 SPDNISSASTSNIARIEEMERLLKQAHAEK-TRLLESREREMEAKKRALEEEKRRREILE 1035
+ + S + + + ++H+ R L+ R++E+++++ +EE +R++E L
Sbjct: 1591 THLTLDLEERSQELQAQSSQIHDLESHSTVLARELQERDQEVKSQREQIEELQRQKEHLT 1650
Query: 1036 KRLQEETSQRQKLIEKEVKIRERQRAQARPLTRYLPVRKEDFD 1078
+ L E Q L ++ +++ E QR TR + +ED +
Sbjct: 1651 QDL-ERRDQELMLQKERIQVLEDQR------TRQTKILEEDLE 1686
Score = 37.4 bits (85), Expect = 0.087
Identities = 126/662 (19%), Positives = 257/662 (38%), Gaps = 90/662 (13%)
Query: 413 KSSISSISGRDDLMDYHRRQREERLR--EQEMERLERQRLETILSL-CAEYTKPDSRLST 469
+ + S+S +L+ R + ++L EQE RL R +E L A+ K + +
Sbjct: 455 QGEVDSLSKERELLQKAREELRQQLEVLEQEAWRLRRVNVELQLQGDSAQGQKEEQQEEL 514
Query: 470 GTTVEDVQKINKELEKLQLSDEESVFEEALMSPDTRYRCHRKDSLPDADLASCGSLSQSS 529
V + +++ + L L+ ES+ E + +++L + L G L +
Sbjct: 515 HLAVRERERLQEMLMGLEAKQSESLSELITL----------REALESSHLE--GELLRQE 562
Query: 530 ASFFTPRSTRNDELLSDLTRTPPPPSSTFPKASSESSYLSILPKTPEGISEEQRSQELAA 589
+ T R ++ +++L+ + + + + LS L + + + +Q+L
Sbjct: 563 QTEVTAALARAEQSIAELSSSENTLKTEVADLRAAAVKLSALNEAL-ALDKVGLNQQLLQ 621
Query: 590 MEETRIVILNNLEELKQKIKDINDQMDESFRELDMECALLDGEQKSETTELMKEKEILDH 649
+EE + + +E +Q + + E+ + + AL + E +L K +E
Sbjct: 622 LEEENQSVCSRMEAAEQARNALQVDLAEAEKRRE---ALWEKNTHLEA-QLQKAEEAGAE 677
Query: 650 LNRKIAELEKNIVGEKTKDADLLDVESKHFEDLEFQQLEHESRLDEEKENLTQQLLREVA 709
L + ++++ EK + L ES+H ++ QLE +L +E + + L R V
Sbjct: 678 LQADLRDIQE----EKEEIQKKLS-ESRHQQEAATTQLE---QLHQEAKRQEEVLARAVQ 729
Query: 710 EYQRNIVSRKEKISALKKQANHIVQQAQREQDHFVKEKNNLIMMLQREKENLCNLEKKYS 769
E KE + K +Q +R++ ++ L + + +L +++ S
Sbjct: 730 E--------KEALVREKAALEVRLQAVERDRQDLAEQLQGLSSAKELLESSLFEAQQQNS 781
Query: 770 SLSGGKG-FPVNPNTLKEGYISVNEINEPCGNSTNLSPSTQFPADADAVATEPATAVLAS 828
+ KG V T+ + V + C + +Q + DA A + A A
Sbjct: 782 VIEVTKGQLEVQIQTVTQAK-EVIQGEVRCLKLELDTERSQAEQERDAAARQLAQA---- 836
Query: 829 QPQSKEHFRSLEERKKQHKEGLYLSDTLPRKKTTSSISPHFSSATMGRSITPKAHLPLGQ 888
+E +LE++K H++ + R+K S H
Sbjct: 837 ---EQEGKTALEQQKAAHEKEV----NQLREKWEKERSWHQQE----------------- 872
Query: 889 SNSCGSVLPPSLAAMAKDSESRRMLRGYNHQQMSEGHRQKSEFYNRTASESNVYLNSFHY 948
L +L ++ ++ M +M Q+ E RT +ES L
Sbjct: 873 -------LAKALESLEREKMELEMRLKEQQTEMEAIQAQREE--ERTQAES--ALCQMQL 921
Query: 949 PDHSYKDQAFDTL------SLDSSDSMETSISACSPDNISSASTSNI--ARIEEMERLLK 1000
+ +TL D+S +E + T+ I +++E +R LK
Sbjct: 922 ETEKERVSLLETLLQTQKELADASQQLERLRQDMKVQKLKEQETTGILQTQLQEAQRELK 981
Query: 1001 Q-AHAEKTRLLESREREMEAKKRALEEEKRRREILEKRLQEETSQRQKLIEKEV--KIRE 1057
+ A + L +E + ++ +K+ ++ + + ++ SQR L+E+EV K+RE
Sbjct: 982 EAARQHRDDLAALQEESSSLLQDKMDLQKQVEDLKSQLVAQDDSQR--LVEQEVQEKLRE 1039
Query: 1058 RQ 1059
Q
Sbjct: 1040 TQ 1041
Score = 35.4 bits (80), Expect = 0.33
Identities = 92/496 (18%), Positives = 190/496 (38%), Gaps = 70/496 (14%)
Query: 582 QRSQELAAMEETRIVILNNLEELKQKIKDINDQMDESFREL---DMECALLDGEQKSETT 638
QR QE+ +++ + E+ + K + + Q+DE+ R L D E L EQ+
Sbjct: 1775 QREQEIVVLQQQ---LQEAREQGELKEQSLQSQLDEAQRALAQRDQELEALQQEQQQAQG 1831
Query: 639 ELMKEKEILDHLNRKIAELEKNIVGEKTKDADLLDVESKHFEDLEFQQLEHESRLDEEKE 698
+ + KE D L LE+ + K + +L D H E + ++LE E ++ +
Sbjct: 1832 QEERVKEKADALQ---GALEQAHMTLKERHGELQD----HKE--QARRLEEELAVEGRRV 1882
Query: 699 NLTQQLLREVAEYQRNIVSRKEKISALKKQANHIVQQAQRE----QDHFVKEKNNLIMML 754
+++L ++ R +++ + AL++Q Q+ + E QD +++ + ++
Sbjct: 1883 QALEEVLGDLRAESR---EQEKALLALQQQCAEQAQEHEVETRALQDSWLQAQ---AVLK 1936
Query: 755 QREKENLCNLEKKYSSLSGGKGFPVNPNTLKEGYISVNEINEPCGNSTNLSPSTQFPADA 814
+R++E + SS + L+E + + G +L +
Sbjct: 1937 ERDQELEALRAESQSSRHQEEAARARAEALQEALGKAHAALQ--GKEQHLLEQAELSRSL 1994
Query: 815 DAVATEPATAVLASQPQSK--EHFRSLEERKKQHKEGLYLSDTLPRKKTTSSISPHFSSA 872
+A ++ A Q S+ E ++E + Q ++ Y D ++ +
Sbjct: 1995 EASTATLQASLDACQAHSRQLEEALRIQEGEIQDQDLRYQEDVQQLQQALAQRDEELRHQ 2054
Query: 873 TMGRSITPKAHLPLGQSNSCGSVLPPSLAAMAKDSESRRMLRGYNHQQMSEGHRQKSEFY 932
+ K+ Q N +L ++ E R + + Q++ +++
Sbjct: 2055 QEREQLLEKSLAQRVQENMIQE--KQNLGQEREEEEIRGLHQSVRELQLTLAQKEQEILE 2112
Query: 933 NRTASESNVYLNSFHYPDHSYKDQAFDTLSLDSSDSMETSISACSPDNISSASTSNIARI 992
R + N+ HS+K + SL DS+E +
Sbjct: 2113 LRETQQR----NNLEALPHSHKTSPMEEQSL-KLDSLEPRLQ------------------ 2149
Query: 993 EEMERLLKQAHAEKTRLLESREREME-----AKKRA-----------LEEEKRRREILEK 1036
E+ERL + R +E RE+ + A+ +A L+ R+ ++
Sbjct: 2150 RELERLQAALRQTEAREIEWREKAQDLALSLAQTKASVSSLQEVAMFLQASVLERDSEQQ 2209
Query: 1037 RLQEETSQRQKLIEKE 1052
RLQ+E ++ +EKE
Sbjct: 2210 RLQDELELTRRALEKE 2225
>gi|114155142 nuclear pore complex-associated protein TPR [Homo
sapiens]
Length = 2363
Score = 55.8 bits (133), Expect = 2e-07
Identities = 129/696 (18%), Positives = 264/696 (37%), Gaps = 102/696 (14%)
Query: 406 QPALRERKSSISSISGRDDLMDYHRRQREERLREQEMERLERQRLETILSLCAEY----T 461
Q + R K S+ DDL+ RQ EE++ + ++RL+T S +Y T
Sbjct: 918 QSSQRTGKGQPSNKEDVDDLVS-QLRQTEEQVNDL------KERLKTSTSNVEQYQAMVT 970
Query: 462 KPDSRLSTGTTVEDVQKINKELEKLQLSDEESVFEEALMSPDTRYRCHRKDSLPDADLAS 521
+ L+ V + + N E+ + ++ ++ E+ LM + K L D +
Sbjct: 971 SLEESLNKEKQVTEEVRKNIEVRLKESAEFQTQLEKKLMEVEKE-----KQELQDDKRRA 1025
Query: 522 CGSLSQSSASFFTPRSTRNDELLSDLTRTPPPPSSTFPKASSESSYLSILPKTPEGISEE 581
S+ Q + S+ +E+ L R S+ + + + + +
Sbjct: 1026 IESMEQQLSELKKTLSSVQNEVQEALQRASTALSN------EQQARRDCQEQAKIAVEAQ 1079
Query: 582 QRSQELAAMEETRIVILNNLEELKQKIKDINDQMDESFRELD---MECALLDGEQ----K 634
+ + + + L +E K+ + ++E+ ++ + +EC E+ K
Sbjct: 1080 NKYERELMLHAADVEALQAAKEQVSKMASVRQHLEETTQKAESQLLECKASWEERERMLK 1139
Query: 635 SETTELMKEKEILDHLNRK------------IAELEKNIVG--------EKTKDADLLDV 674
E ++ + E L+ NR +A +++ + G E +L++
Sbjct: 1140 DEVSKCVCRCEDLEKQNRLLHDQIEKLSDKVVASVKEGVQGPLNVSLSEEGKSQEQILEI 1199
Query: 675 -----ESKHFEDLEFQQLEHESRLDEEKENLTQQLLREVAEYQRNIVSRKEKISALKK-Q 728
K + F+ + ES ++ L + RE+ E Q ++ + +EK+ K
Sbjct: 1200 LRFIRREKEIAETRFEVAQVESLRYRQRVELLE---RELQELQDSLNAEREKVQVTAKTM 1256
Query: 729 ANHIVQQAQREQDHFVKEKNNLIMMLQREKENLCNLEKKYSSLSGGKGFPVNPNTLKEGY 788
A H + E + V E N ML+ EKE L E+ + L+
Sbjct: 1257 AQHEELMKKTETMNVVMETNK---MLREEKERL---EQDLQQMQA------KVRKLELDI 1304
Query: 789 ISVNEINEPCGNSTNLSPSTQFPADADAVATEPATAVLASQ---PQSKEHFRSLEERKKQ 845
+ + E N + + + + + D + L SQ P ++E+ + L E++
Sbjct: 1305 LPLQEANAELSEKSGMLQAEKKLLEEDVKRWKARNQHLVSQQKDPDTEEYRKLLSEKEVH 1364
Query: 846 HKEGLYLSDTLPRKKTTSSISPHFSSATMGRSITPKAHLPLGQSNSCGSVLPPSLAAMAK 905
K L++ + R K + I+ +S T +++ L + + + L A
Sbjct: 1365 TKRIQQLTEEIGRLK--AEIARSNASLTNNQNLIQSLKEDLNKVRTEKETIQKDLDAKII 1422
Query: 906 DSESRRMLRGYNHQQMSEGHRQKSEFYNRTASESNVYLNSFHYPDHSYKDQAFDTLSLDS 965
D + + Q G R K+++ A + D+ +T + S
Sbjct: 1423 DIQEKVKTIT---QVKKIGRRYKTQYEELKAQQ----------------DKVMETSAQSS 1463
Query: 966 SDSMETSISACS----PDNISSASTSNIARIEEMERLLKQAHAEKTRLLESREREMEAKK 1021
D E +S + ++ A T + + ++E L K ++T +E+ ++ +
Sbjct: 1464 GDHQEQHVSVQEMQELKETLNQAETKSKSLESQVENLQKTLSEKETEARNLQEQTVQLQS 1523
Query: 1022 RALEEEKRRREILEKRLQEETSQRQKLIEKEVKIRE 1057
E R R+ L+ R +E RQ++ EKE K R+
Sbjct: 1524 ----ELSRLRQDLQDRTTQEEQLRQQITEKEEKTRK 1555
Score = 50.8 bits (120), Expect = 8e-06
Identities = 54/238 (22%), Positives = 104/238 (43%), Gaps = 38/238 (15%)
Query: 560 KASSESSYLSI---LPKTPEGISEEQRSQELAAMEETRIVILNNLEELKQKIKDINDQMD 616
K SE Y I L + E + E R + +E ++ N L+ L +K K++ D
Sbjct: 47 KVESEQQYFEIEKRLSHSQERLVNETRECQSLRLELEKLN--NQLKALTEKNKELEIAQD 104
Query: 617 ESFRELDMECALLDGEQKSETTELMKEKEIL----DHLNRKIAELEKNIVGEKTKDADL- 671
+ + + E ++E +L++ E L ++L + L + + T +L
Sbjct: 105 RNIA-IQSQFTRTKEELEAEKRDLIRTNERLSQELEYLTEDVKRLNEKLKESNTTKGELQ 163
Query: 672 LDVESKHFEDLEFQQLEHESRLDEEKENL--------------TQQLL-------REVAE 710
L ++ D+ + E RL++EKE L T +LL E+ E
Sbjct: 164 LKLDELQASDVSVKY--REKRLEQEKELLHSQNTWLNTELKTKTDELLALGREKGNEILE 221
Query: 711 YQRNIVSRKEKISALKKQANHIVQQAQREQDHFVKEKNNLIMMLQREKENLCNLEKKY 768
+ N+ ++KE++S L++Q N + + +H K +L+ L+ KE ++E+K+
Sbjct: 222 LKCNLENKKEEVSRLEEQMNGL----KTSNEHLQKHVEDLLTKLKEAKEQQASMEEKF 275
Score = 48.1 bits (113), Expect = 5e-05
Identities = 67/380 (17%), Positives = 166/380 (43%), Gaps = 22/380 (5%)
Query: 397 SLRQASGTPQPA-LRERKSSISSISGRDDLMDYHRRQREERLREQEMERLERQRL-ETIL 454
S Q TP P + E +I + + L + ++E+ ++++ + ++L E +
Sbjct: 646 STSQTVSTPAPVPVIESTEAIEAKAALKQLQEIFENYKKEKAENEKIQNEQLEKLQEQVT 705
Query: 455 SLCAEYTKPDSRLSTGTTVEDVQKINKELEKLQLSDEESVFEEALMSPDTRYRCHRKDSL 514
L ++ TK ++L + ++ + N E + +++ S+ E T + + +
Sbjct: 706 DLRSQNTKISTQLDFASKRYEMLQDNVEGYRREIT---SLHERNQKLTATTQKQEQIINT 762
Query: 515 PDADLASCGSLSQSSASFFTPRSTRNDELLSDLT--RTPPPPSSTFPKASSESSYLSILP 572
DL G+ + + + + + ++ + L+ R S + ++ L+ L
Sbjct: 763 MTQDLR--GANEKLAVAEVRAENLKKEKEMLKLSEVRLSQQRESLLAEQRGQNLLLTNL- 819
Query: 573 KTPEGISEEQRSQELAAMEETRIVILNNLEELKQKIKDINDQMDESFRELDMECALLDGE 632
+T +GI E ++ + + + + LK+K+++ +Q R LD++ +
Sbjct: 820 QTIQGILERSETETKQRLSSQIEKLEHEISHLKKKLENEVEQRHTLTRNLDVQLLDTKRQ 879
Query: 633 QKSETTELMKEKEILDHLNRKIAELEKNIVGEKTKDADLLDVES--------KHFEDLEF 684
+ET + KE+L + ++IA L++++ + + A + + +DL
Sbjct: 880 LDTETNLHLNTKELLKNAQKEIATLKQHLSNMEVQVASQSSQRTGKGQPSNKEDVDDLVS 939
Query: 685 QQLEHESRLDEEKENLTQQLLREVAEYQRNIVSRKEKISALKKQANHI---VQQAQREQD 741
Q + E ++++ KE L + V +YQ + S +E ++ K+ + ++ +E
Sbjct: 940 QLRQTEEQVNDLKERL-KTSTSNVEQYQAMVTSLEESLNKEKQVTEEVRKNIEVRLKESA 998
Query: 742 HFVKEKNNLIMMLQREKENL 761
F + +M +++EK+ L
Sbjct: 999 EFQTQLEKKLMEVEKEKQEL 1018
Score = 38.5 bits (88), Expect = 0.039
Identities = 92/448 (20%), Positives = 174/448 (38%), Gaps = 54/448 (12%)
Query: 636 ETTELMKEKEILDHLNRKIAELEKNIVGEKTKDADLLDVESKHFEDLEFQQLEHESRLDE 695
E+TE ++ K L L +K + + L+ + DL Q + ++LD
Sbjct: 661 ESTEAIEAKAALKQLQEIFENYKKEKAENEKIQNEQLEKLQEQVTDLRSQNTKISTQLDF 720
Query: 696 EKENLTQQLLREVAEYQRNIVS---RKEKISALKKQANHIVQQAQREQDHFVKEKNNLIM 752
+ + L V Y+R I S R +K++A ++ I+ ++ ++ N +
Sbjct: 721 ASKRY-EMLQDNVEGYRREITSLHERNQKLTATTQKQEQIINTMTQD----LRGANEKLA 775
Query: 753 MLQREKENLCNLEKKYSSLSGGKGFPVNPNTLKEGYISVNEINEPCGNSTNLSPSTQFPA 812
+ + ENL EK+ LS V + +E ++ E G + L+
Sbjct: 776 VAEVRAENL-KKEKEMLKLS-----EVRLSQQRESLLA-----EQRGQNLLLTNLQTIQG 824
Query: 813 DADAVATEPATAVLASQPQSKEHFRSLEERKKQHKE----------GLYLSDTLPRKKTT 862
+ TE L+SQ + EH S ++K +++ + L DT + T
Sbjct: 825 ILERSETETKQR-LSSQIEKLEHEISHLKKKLENEVEQRHTLTRNLDVQLLDTKRQLDTE 883
Query: 863 SSISPHFSSATMGRSI-----TPKAHLPLGQSNSCGSVLPPSLAAMAKDSESRRMLRGYN 917
+++ H ++ + ++ T K HL SN V S K S +
Sbjct: 884 TNL--HLNTKELLKNAQKEIATLKQHL----SNMEVQVASQSSQRTGKGQPSNKEDVDDL 937
Query: 918 HQQMSEGHRQKSEFYNRT-ASESNVYLNSFHYPDHSYKDQAFDTLSLDSSDSMETSISAC 976
Q+ + Q ++ R S SNV + QA T SL+ S + E ++
Sbjct: 938 VSQLRQTEEQVNDLKERLKTSTSNVE-----------QYQAMVT-SLEESLNKEKQVTEE 985
Query: 977 SPDNISSASTSNIARIEEMERLLKQAHAEKTRLLESREREMEAKKRALEEEKRRREILEK 1036
NI + ++E+ L + EK L + + R +E+ ++ L E K+ ++
Sbjct: 986 VRKNIEVRLKESAEFQTQLEKKLMEVEKEKQELQDDKRRAIESMEQQLSELKKTLSSVQN 1045
Query: 1037 RLQEETSQRQKLIEKEVKIRERQRAQAR 1064
+QE + + E + R + QA+
Sbjct: 1046 EVQEALQRASTALSNEQQARRDCQEQAK 1073
Score = 37.7 bits (86), Expect = 0.067
Identities = 85/404 (21%), Positives = 157/404 (38%), Gaps = 78/404 (19%)
Query: 408 ALRERKSSISSISGRDDLMDYHRRQREERLREQEMERLERQRLETILSLCAEYTKPDSRL 467
AL E+ + R+ + + +E L E E+ + R LS EY
Sbjct: 91 ALTEKNKELEIAQDRNIAIQSQFTRTKEEL---EAEKRDLIRTNERLSQELEYL------ 141
Query: 468 STGTTVEDVQKINKELEKLQLSDEESVFE-EALMSPDTRYRCHRKDSLPDADLASCGSLS 526
EDV+++N++L++ + E + + L + D + K + +L L
Sbjct: 142 -----TEDVKRLNEKLKESNTTKGELQLKLDELQASDVSVKYREKRLEQEKEL-----LH 191
Query: 527 QSSASFFTPRSTRNDELLSDLTRTPPPPSSTFPKASSESSYLSILPKTPEGISEEQRSQE 586
+ T T+ DELL+ L R K + L E +S + ++
Sbjct: 192 SQNTWLNTELKTKTDELLA-LGRE---------KGNEILELKCNLENKKEEVSRLE--EQ 239
Query: 587 LAAMEETRIVILNNLEELKQKIKDINDQ---MDESFR-ELDMECALLDGEQKSETTELMK 642
+ ++ + + ++E+L K+K+ +Q M+E F EL+ L + + + K
Sbjct: 240 MNGLKTSNEHLQKHVEDLLTKLKEAKEQQASMEEKFHNELNAHIKLSNLYKSAADDSEAK 299
Query: 643 EKEILDHLNRKIAELEKNI--VGEKTKDAD--LLDVESKHFEDLEFQQLEHESRLDEEKE 698
E L R + EL K + GE K LL+VE + +E + LE RL++E E
Sbjct: 300 SNE----LTRAVEELHKLLKEAGEANKAIQDHLLEVEQSK-DQMEKEMLEKIGRLEKELE 354
Query: 699 NLTQQLLREVAEYQRNIVSRKEKISALKKQANHIVQ------------------------ 734
N L A ++ + +E+++A+ A + +
Sbjct: 355 NANDLLS---ATKRKGAILSEEELAAMSPTAAAVAKIVKPGMKLTELYNAYVETQDQLLL 411
Query: 735 ------QAQREQDHFVKEKNNLIMMLQREKENLCNLEKKYSSLS 772
+ + D VKE +L+R++E +K +SLS
Sbjct: 412 EKLENKRINKYLDEIVKEVEAKAPILKRQREEYERAQKAVASLS 455
Score = 31.2 bits (69), Expect = 6.2
Identities = 27/107 (25%), Positives = 48/107 (44%), Gaps = 7/107 (6%)
Query: 967 DSMETSISACSPDN--ISSASTSNIARIEEMERLLKQAHAEKTRLLESREREMEAKKRAL 1024
+ + + A + N + A NIA + R ++ AEK L+ + ER + +
Sbjct: 83 EKLNNQLKALTEKNKELEIAQDRNIAIQSQFTRTKEELEAEKRDLIRTNERLSQELEYLT 142
Query: 1025 EEEKRRREILEKRLQEETSQRQKLIEKE-----VKIRERQRAQARPL 1066
E+ KR E L++ + + KL E + VK RE++ Q + L
Sbjct: 143 EDVKRLNEKLKESNTTKGELQLKLDELQASDVSVKYREKRLEQEKEL 189
>gi|110624781 myosin, heavy polypeptide 13, skeletal muscle [Homo
sapiens]
Length = 1938
Score = 55.5 bits (132), Expect = 3e-07
Identities = 79/392 (20%), Positives = 170/392 (43%), Gaps = 43/392 (10%)
Query: 386 GSVEFDEADLESLRQASGTPQPALRERKSSISSISGRDDLMDYHRRQREERLREQE--ME 443
G ++ + + L + L++++ +S + + D H Q +++++E + +E
Sbjct: 1061 GDLKMSQESIMDLENDKQQIEEKLKKKEFELSQLQAKIDDEQVHSLQFQKKIKELQARIE 1120
Query: 444 RLERQRLETILSLCAEYTKPDSRLSTGTTVEDVQKINKELEKLQLSDEESVFEEALMSPD 503
LE + +E +L A+ K S L+ ++++I++ LE + S S E +
Sbjct: 1121 ELEEE-IEAEHTLRAKIEKQRSDLA-----RELEEISERLE--EASGATSAQIEMNKKRE 1172
Query: 504 TRYRCHRKDSLPDADL---ASCGSLSQSSASFFTPRSTRNDELLSDLTRTPPPPSSTFPK 560
++ R+D L +A L A+ +L + A + D L + S +
Sbjct: 1173 AEFQKMRRD-LEEATLQHEATAATLRKKQADSVAELGEQIDNLQRVKQKLEKEKSELKME 1231
Query: 561 ASSESSYLSILPKTPEGISE-----EQRSQELAAMEETRIVILNNLEELKQKIKDINDQM 615
+S + L K+ I E + E+ A +E + ++++L K +++ N ++
Sbjct: 1232 IDDMASNIEALSKSKSNIERTCRTVEDQFSEIKAKDEQQTQLIHDLNMQKARLQTQNGEL 1291
Query: 616 DESFRELDMECALLDGEQKSETTELMKEKEILDHLNRKIAELEKNIVGE-KTKDADLLDV 674
E ++S ++L K K+ L +++ EL++ + E K K+A +
Sbjct: 1292 SHRVEE-----------KESLISQLTKSKQAL---TQQLEELKRQMEEETKAKNAMAHAL 1337
Query: 675 ES-KHFEDLEFQQLEHESRLDEEKENLTQQLLREVAE----YQRNIVSRKEKISALKKQA 729
+S +H DL +Q E E E + + EVA+ Y+ + + R E++ KK+
Sbjct: 1338 QSSRHDCDLLREQYEEEQEAKAELQRALSKANSEVAQWRTKYETDAIQRTEELEEAKKKL 1397
Query: 730 NHIVQQAQREQDHFVKEKNNLIMMLQREKENL 761
+Q+A+ + N+ L++ K+ L
Sbjct: 1398 AQRLQEAEEN----TETANSKCASLEKTKQRL 1425
Score = 46.6 bits (109), Expect = 1e-04
Identities = 76/372 (20%), Positives = 151/372 (40%), Gaps = 35/372 (9%)
Query: 388 VEFDE--ADLESLRQASGTPQPALRERKSSISSISGRDDLMDYHRRQREERLREQEMERL 445
+E D+ +++E+L ++ + R + S I +D+ Q+ + + + M++
Sbjct: 1230 MEIDDMASNIEALSKSKSNIERTCRTVEDQFSEIKAKDE-------QQTQLIHDLNMQKA 1282
Query: 446 ERQRLETILSLCAEYTKPDSRLSTGTTVEDVQKINKELEKLQLSDEESVFEEALMSPDTR 505
Q LS E + +S +S T + Q + ++LE+L+ EE + M+ +
Sbjct: 1283 RLQTQNGELSHRVE--EKESLISQLT--KSKQALTQQLEELKRQMEEETKAKNAMAHALQ 1338
Query: 506 YRCHRKDSLPDADLASCGSLSQSSASFFTPRSTRNDELLSDLTRTPPPPSSTFPKASSES 565
H D L + ++ A S N E+ T+ +
Sbjct: 1339 SSRHDCDLLRE----QYEEEQEAKAELQRALSKANSEVAQWRTKYETDAIQRTEELEEAK 1394
Query: 566 SYLSILPKTPEGISEEQRSQELAAMEETRIVILNNLEELKQKIKDINDQMDESFRELDME 625
L+ QR QE ET +LE+ KQ+++ + +
Sbjct: 1395 KKLA------------QRLQEAEENTETANSKCASLEKTKQRLQGEVEDLMRDLERSHTA 1442
Query: 626 CALLDGEQKSETTELMKEKEILDHLNRKIAELEKNIVGEKTKDADLLDVESKHFEDLEFQ 685
CA LD +Q++ L + K+ LD ++ +K T+ + + + + LE
Sbjct: 1443 CATLDKKQRNFDKVLAEWKQKLDESQAELEAAQKESRSLSTELFKMRNAYEEVVDQLETL 1502
Query: 686 QLEHESRLDEEKENLTQQLLREVAEYQRNIVSRKEKISALKKQANHIVQQAQREQDHFVK 745
+ E+++ L EE +LT+Q +AE +N+ EK L +Q +Q A E + ++
Sbjct: 1503 RRENKN-LQEEISDLTEQ----IAETGKNL-QEAEKTKKLVEQEKSDLQVALEEVEGSLE 1556
Query: 746 EKNNLIMMLQRE 757
+ + I+ +Q E
Sbjct: 1557 HEESKILRVQLE 1568
Score = 45.1 bits (105), Expect = 4e-04
Identities = 41/209 (19%), Positives = 88/209 (42%), Gaps = 16/209 (7%)
Query: 579 SEEQRSQELAAMEETRIVILNNLEELKQKIKDIND---QMDESFRELDMECALLDGEQKS 635
S EQ + A +E + + +L+ ++ I D+ + Q++E ++ + E + L +
Sbjct: 1041 SLEQEKKLRADLERAKRKLEGDLKMSQESIMDLENDKQQIEEKLKKKEFELSQLQAKIDD 1100
Query: 636 ETTELMKEKEILDHLNRKIAELEKNIVGEKTKDADLLDVESKHFEDLE------------ 683
E ++ ++ + L +I ELE+ I E T A + S +LE
Sbjct: 1101 EQVHSLQFQKKIKELQARIEELEEEIEAEHTLRAKIEKQRSDLARELEEISERLEEASGA 1160
Query: 684 -FQQLEHESRLDEEKENLTQQLLREVAEYQRNIVSRKEKISALKKQANHIVQQAQREQDH 742
Q+E + + E + + + L +++ + ++K + + + QR +
Sbjct: 1161 TSAQIEMNKKREAEFQKMRRDLEEATLQHEATAATLRKKQADSVAELGEQIDNLQRVKQK 1220
Query: 743 FVKEKNNLIMMLQREKENLCNLEKKYSSL 771
KEK+ L M + N+ L K S++
Sbjct: 1221 LEKEKSELKMEIDDMASNIEALSKSKSNI 1249
Score = 38.9 bits (89), Expect = 0.030
Identities = 78/387 (20%), Positives = 166/387 (42%), Gaps = 53/387 (13%)
Query: 412 RKSSISSISGRDDLMDYHRRQREERLREQEMERLERQRLETILSLCAEYTKPDSRLS-TG 470
RK S++ + +D +R +++ +E+ ++E ++ + S +K S + T
Sbjct: 1197 RKKQADSVAELGEQIDNLQRVKQKLEKEKSELKME---IDDMASNIEALSKSKSNIERTC 1253
Query: 471 TTVED---------------VQKINKELEKLQLSDEESVF----EEALMSPDTRYRCHRK 511
TVED + +N + +LQ + E +E+L+S T+ +
Sbjct: 1254 RTVEDQFSEIKAKDEQQTQLIHDLNMQKARLQTQNGELSHRVEEKESLISQLTKSKQALT 1313
Query: 512 DSLPDADLASCGSLSQSSASFFTPRSTRNDELLSDLTRTPPPPSSTFPKASSESSYLSIL 571
L + +A +S+R+D DL R + +++ L
Sbjct: 1314 QQLEELKRQMEEETKAKNAMAHALQSSRHD---CDLLR-----EQYEEEQEAKAELQRAL 1365
Query: 572 PKTPEGISEEQRSQELAAMEETRIVILNNLEELKQKIKDINDQMDESFRELDMECALLDG 631
K +++ + E A++ T LEE K+K+ + +E+ + +CA L+
Sbjct: 1366 SKANSEVAQWRTKYETDAIQRTE-----ELEEAKKKLAQRLQEAEENTETANSKCASLEK 1420
Query: 632 EQ---KSETTELMKEKEILDHLNRKIAELEKNIVGEKTKDADLLDVESKHFE---DLEFQ 685
+ + E +LM++ L+ + A L+K ++ D L + + K E +LE
Sbjct: 1421 TKQRLQGEVEDLMRD---LERSHTACATLDKK---QRNFDKVLAEWKQKLDESQAELEAA 1474
Query: 686 QLEHESRLDE--EKENLTQQLLREVAEYQRNIVSRKEKISALKKQ---ANHIVQQAQREQ 740
Q E S E + N ++++ ++ +R + +E+IS L +Q +Q+A++ +
Sbjct: 1475 QKESRSLSTELFKMRNAYEEVVDQLETLRRENKNLQEEISDLTEQIAETGKNLQEAEKTK 1534
Query: 741 DHFVKEKNNLIMMLQREKENLCNLEKK 767
+EK++L + L+ + +L + E K
Sbjct: 1535 KLVEQEKSDLQVALEEVEGSLEHEESK 1561
Score = 38.1 bits (87), Expect = 0.051
Identities = 72/360 (20%), Positives = 151/360 (41%), Gaps = 43/360 (11%)
Query: 388 VEFDEADLESLRQASGTPQPALRERKSSISSISGRDDLMDYHRRQREERLREQEME--RL 445
+E DE ++E L++ S AL+ + I R+D + +++ E L E E++
Sbjct: 1581 IEKDE-EIEQLKRNSQRAAEALQSVLDA--EIRSRNDALRL-KKKMEGDLNEMEIQLGHS 1636
Query: 446 ERQRLETILSL-CAEYTKPDSRLSTGTTVEDVQKINKEL-EKLQLSDEES--VFEEALMS 501
RQ ET L + DS+L ++D + N++L E+L + + + + EE
Sbjct: 1637 NRQMAETQKHLRTVQGQLKDSQLH----LDDALRSNEDLKEQLAIVERRNGLLLEELEEM 1692
Query: 502 PDTRYRCHRKDSLPDADLASCGSLSQSSASFFTPRSTRNDELLSDLTRTPPPPSSTFPKA 561
+ R L + +L Q S T +L +D+ + ++ ++
Sbjct: 1693 KVALEQTERTRRLSEQELLDASDRVQLLHSQNTSLINTKKKLEADIAQCQAEVENSIQES 1752
Query: 562 SSESSYLSILPKTPEGISEE-QRSQELAAMEETRIVILNNLEELKQKIKDINDQMDESFR 620
+ K + I++ ++EL ++T + + L+Q +KD+ ++DE
Sbjct: 1753 RNAEE------KAKKAITDAAMMAEELKKEQDTSAHLERMKKNLEQTVKDLQHRLDE--- 1803
Query: 621 ELDMECALLDGEQKSETTELMKEKEILDHLNRKIAELEKNIVGEKTKDADLLDVESKHFE 680
+E L K+ + L ++ ELE + E+ + A+ L + H
Sbjct: 1804 --------------AEQLALKGGKKQIQKLENRVRELENELDVEQKRGAEAL--KGAHKY 1847
Query: 681 DLEFQQLEHESRLDEEKENLTQQLLREVAEYQRNIVSRKEKISALKKQANHIVQQAQREQ 740
+ + +++ +++ D + Q L V + Q + S K + ++QAN + + +R Q
Sbjct: 1848 ERKVKEMTYQAEEDHKNILRLQDL---VDKLQAKVKSYKRQAEEAEEQANTQLSRCRRVQ 1904
Score = 35.8 bits (81), Expect = 0.25
Identities = 37/145 (25%), Positives = 60/145 (41%), Gaps = 37/145 (25%)
Query: 990 ARIEEMERLLKQAHAEKTRLLESRE---REMEA-------------------KKRALEEE 1027
ARIEE+E ++ H + ++ + R RE+E KKR E +
Sbjct: 1117 ARIEELEEEIEAEHTLRAKIEKQRSDLARELEEISERLEEASGATSAQIEMNKKREAEFQ 1176
Query: 1028 KRRREILEKRLQEETS-------QRQKLIEKEVKIRERQRAQARPLTRYLPVRKEDFDLR 1080
K RR++ E LQ E + Q + E +I QR + + + KE +L+
Sbjct: 1177 KMRRDLEEATLQHEATAATLRKKQADSVAELGEQIDNLQRVKQK-------LEKEKSELK 1229
Query: 1081 SHVETAGHNIDT-CYHVSITEKTCR 1104
++ NI+ S E+TCR
Sbjct: 1230 MEIDDMASNIEALSKSKSNIERTCR 1254
>gi|118498356 kinectin 1 isoform a [Homo sapiens]
Length = 1357
Score = 55.1 bits (131), Expect = 4e-07
Identities = 145/741 (19%), Positives = 292/741 (39%), Gaps = 88/741 (11%)
Query: 398 LRQASGTPQPALRERKSSISSISGRDDLMDYHRRQREERLREQEMERLERQRLETILSLC 457
+R+ + + A ++ +S ++ +++ H + + + +Q++E+ Q +E+
Sbjct: 504 IRKRTAEHEAAQQDLQSKF--VAKENEVQSLHSKLTDTLVSKQQLEQRLMQLMES----- 556
Query: 458 AEYTKPDSRLSTGTTVEDVQKINKELEKLQLSDEESVFEEALMSPDTRYRCHRKDSLPDA 517
E + + S V+D+ + N+ L K Q+ S + H+ + D
Sbjct: 557 -EQKRVNKEESLQMQVQDILEQNEAL-KAQIQQFHSQIAAQTSASVLAEELHKVIAEKDK 614
Query: 518 DLASCGSLSQSSASFFTPRSTRNDELLSDLTRTPPPPSSTFPK----ASSESSYLSILPK 573
+ ++ S + R T +E L D+ + K A+ +++ L K
Sbjct: 615 QIKQ----TEDSLASERDRLTSKEEELKDIQNMNFLLKAEVQKLQALANEQAAAAHELEK 670
Query: 574 TPEGIS---------EEQRSQELA-AMEETRIVILNN--LEELKQKI---------KDIN 612
+ + EEQ E++ MEE +I+ N L+ QK+ KD+
Sbjct: 671 MQQSVYVKDDKIRLLEEQLQHEISNKMEEFKILNDQNKALKSEVQKLQTLVSEQPNKDVV 730
Query: 613 DQMDESFRELDMECALLDGEQKSETTELMKEKEILDHLNRKIAELEKNIVGEKTKDADLL 672
+QM++ +E D + ++ ++ ++ ++E L+ + + + L K + K K D +
Sbjct: 731 EQMEKCIQEKDEKLKTVEELLETGLIQVATKEEELNAIRTENSSLTKEVQDLKAKQNDQV 790
Query: 673 DVESKHFEDLEFQQLEHESRLDEEKENLTQQLLREVAEYQRNIVSRKEKISALKKQANHI 732
S E+L+ E + ++ +E L +LL+ VA ++ + K++I ALK++ ++
Sbjct: 791 SFASL-VEELKKVIHEKDGKIKSVEELLEAELLK-VANKEKTVQDLKQEIKALKEEIGNV 848
Query: 733 VQQAQREQDHFVKEKNNLIMMLQREKENLCN-----LEKKYSSLSG-GKGFPVNPNTLKE 786
Q ++ Q + K + L + KE N LE+K L+ GK +
Sbjct: 849 --QLEKAQQLSITSKVQELQNLLKGKEEQMNTMKAVLEEKEKDLANTGKWLQDLQEENES 906
Query: 787 GYISVNEINEPCGNSTNLSPSTQFPADADAVATEPATAVLASQPQSKEHFRSLEERKK-- 844
V E+ + N S ++QF + + V E + + KE L + +
Sbjct: 907 LKAHVQEVAQ--HNLKEASSASQF-EELEIVLKEKENELKRLEAMLKERESDLSSKTQLL 963
Query: 845 ---QHKEGLYLSDTLPRK----KTTSSISPHFSSATMGRSITPKAHLPLGQSNSCGSVLP 897
Q + L+ S K + SS PH + + I+ + G N S L
Sbjct: 964 QDVQDENKLFKSQIEQLKQQNYQQASSFPPH---EELLKVISEREKEISGLWNELDS-LK 1019
Query: 898 PSLAAMAKDSESRRMLRGYNHQQMSEGHRQKSEFYNRTASESNVYLNSFHYPDHSYKDQA 957
++ K + R + ++ + + N+T+ E + + +
Sbjct: 1020 DAVEHQRKKNNDLREKNWEAMEALASTEKMLQDKVNKTSKERQQQVEAVELEAKEVLKKL 1079
Query: 958 FDTLSLDSSDS-------METSISACSPDNISSASTSNIARIEEMERLLKQAHAEKTRLL 1010
F +S+ S+ S E C A TS ++ +E LK+A T L
Sbjct: 1080 FPKVSVPSNLSYGEWLHGFEKKAKEC------MAGTSGSEEVKVLEHKLKEADEMHTLL- 1132
Query: 1011 ESREREMEAKKRALEEEKRRREILEKRL-QEETSQRQKLIEKEVKIRERQRAQARPLTRY 1069
+ E E K L E + + L++ + QEE + K+ E I++ Q +
Sbjct: 1133 ---QLECEKYKSVLAETEGILQKLQRSVEQEENKWKVKVDESHKTIKQMQSSFTSSEQEL 1189
Query: 1070 LPVRKEDFDL------RSHVE 1084
+R E+ D+ R H+E
Sbjct: 1190 ERLRSENKDIENLRREREHLE 1210
Score = 46.2 bits (108), Expect = 2e-04
Identities = 67/328 (20%), Positives = 126/328 (38%), Gaps = 29/328 (8%)
Query: 409 LRERKSSISSISGRDDLMDYHRRQREERLREQEMERLERQRLETILSLCAEYTKPDSRLS 468
LRE+ + M + + + R+Q++E +E + E + L + + P S LS
Sbjct: 1032 LREKNWEAMEALASTEKMLQDKVNKTSKERQQQVEAVELEAKEVLKKLFPKVSVP-SNLS 1090
Query: 469 TGTTVEDVQKINKE-LEKLQLSDEESVFEEALMSPDTRY-----RCHRKDSLPDADLASC 522
G + +K KE + S+E V E L D + C + S+ LA
Sbjct: 1091 YGEWLHGFEKKAKECMAGTSGSEEVKVLEHKLKEADEMHTLLQLECEKYKSV----LAET 1146
Query: 523 GSLSQSSASFFTPRSTRNDELLSDLTRTPPPPSSTFPKASSESSYLSILPKTPEGISEEQ 582
+ Q + + + +T S+F + E L K E + E+
Sbjct: 1147 EGILQKLQRSVEQEENKWKVKVDESHKTIKQMQSSFTSSEQELERLRSENKDIENLRRER 1206
Query: 583 R--SQELAAMEETRIVILNNLEELKQKIKDINDQMDESFREL---DMECALLDGEQKSET 637
EL E R + + ELK + ++ ++D+S+ E + E LL +
Sbjct: 1207 EHLEMELEKAEMERSTYVTEVRELKDLLTELQKKLDDSYSEAVRQNEELNLLKAQLNETL 1266
Query: 638 TELMKEKEILD------HLNRKIAELEKNIVGEKTKDADLL-------DVESKHFEDLEF 684
T+L E+ H ++ EL ++ + + D ++ + ES E +
Sbjct: 1267 TKLRTEQNERQKVAGDLHKAQQSLELIQSKIVKAAGDTTVIENSDVSPETESSEKETMSV 1326
Query: 685 QQLEHESRLDEEKENLTQQLLREVAEYQ 712
+ ++L + + + QQL +E YQ
Sbjct: 1327 SLNQTVTQLQQLLQAVNQQLTKEKEHYQ 1354
>gi|33620775 kinectin 1 isoform a [Homo sapiens]
Length = 1357
Score = 55.1 bits (131), Expect = 4e-07
Identities = 145/741 (19%), Positives = 292/741 (39%), Gaps = 88/741 (11%)
Query: 398 LRQASGTPQPALRERKSSISSISGRDDLMDYHRRQREERLREQEMERLERQRLETILSLC 457
+R+ + + A ++ +S ++ +++ H + + + +Q++E+ Q +E+
Sbjct: 504 IRKRTAEHEAAQQDLQSKF--VAKENEVQSLHSKLTDTLVSKQQLEQRLMQLMES----- 556
Query: 458 AEYTKPDSRLSTGTTVEDVQKINKELEKLQLSDEESVFEEALMSPDTRYRCHRKDSLPDA 517
E + + S V+D+ + N+ L K Q+ S + H+ + D
Sbjct: 557 -EQKRVNKEESLQMQVQDILEQNEAL-KAQIQQFHSQIAAQTSASVLAEELHKVIAEKDK 614
Query: 518 DLASCGSLSQSSASFFTPRSTRNDELLSDLTRTPPPPSSTFPK----ASSESSYLSILPK 573
+ ++ S + R T +E L D+ + K A+ +++ L K
Sbjct: 615 QIKQ----TEDSLASERDRLTSKEEELKDIQNMNFLLKAEVQKLQALANEQAAAAHELEK 670
Query: 574 TPEGIS---------EEQRSQELA-AMEETRIVILNN--LEELKQKI---------KDIN 612
+ + EEQ E++ MEE +I+ N L+ QK+ KD+
Sbjct: 671 MQQSVYVKDDKIRLLEEQLQHEISNKMEEFKILNDQNKALKSEVQKLQTLVSEQPNKDVV 730
Query: 613 DQMDESFRELDMECALLDGEQKSETTELMKEKEILDHLNRKIAELEKNIVGEKTKDADLL 672
+QM++ +E D + ++ ++ ++ ++E L+ + + + L K + K K D +
Sbjct: 731 EQMEKCIQEKDEKLKTVEELLETGLIQVATKEEELNAIRTENSSLTKEVQDLKAKQNDQV 790
Query: 673 DVESKHFEDLEFQQLEHESRLDEEKENLTQQLLREVAEYQRNIVSRKEKISALKKQANHI 732
S E+L+ E + ++ +E L +LL+ VA ++ + K++I ALK++ ++
Sbjct: 791 SFASL-VEELKKVIHEKDGKIKSVEELLEAELLK-VANKEKTVQDLKQEIKALKEEIGNV 848
Query: 733 VQQAQREQDHFVKEKNNLIMMLQREKENLCN-----LEKKYSSLSG-GKGFPVNPNTLKE 786
Q ++ Q + K + L + KE N LE+K L+ GK +
Sbjct: 849 --QLEKAQQLSITSKVQELQNLLKGKEEQMNTMKAVLEEKEKDLANTGKWLQDLQEENES 906
Query: 787 GYISVNEINEPCGNSTNLSPSTQFPADADAVATEPATAVLASQPQSKEHFRSLEERKK-- 844
V E+ + N S ++QF + + V E + + KE L + +
Sbjct: 907 LKAHVQEVAQ--HNLKEASSASQF-EELEIVLKEKENELKRLEAMLKERESDLSSKTQLL 963
Query: 845 ---QHKEGLYLSDTLPRK----KTTSSISPHFSSATMGRSITPKAHLPLGQSNSCGSVLP 897
Q + L+ S K + SS PH + + I+ + G N S L
Sbjct: 964 QDVQDENKLFKSQIEQLKQQNYQQASSFPPH---EELLKVISEREKEISGLWNELDS-LK 1019
Query: 898 PSLAAMAKDSESRRMLRGYNHQQMSEGHRQKSEFYNRTASESNVYLNSFHYPDHSYKDQA 957
++ K + R + ++ + + N+T+ E + + +
Sbjct: 1020 DAVEHQRKKNNDLREKNWEAMEALASTEKMLQDKVNKTSKERQQQVEAVELEAKEVLKKL 1079
Query: 958 FDTLSLDSSDS-------METSISACSPDNISSASTSNIARIEEMERLLKQAHAEKTRLL 1010
F +S+ S+ S E C A TS ++ +E LK+A T L
Sbjct: 1080 FPKVSVPSNLSYGEWLHGFEKKAKEC------MAGTSGSEEVKVLEHKLKEADEMHTLL- 1132
Query: 1011 ESREREMEAKKRALEEEKRRREILEKRL-QEETSQRQKLIEKEVKIRERQRAQARPLTRY 1069
+ E E K L E + + L++ + QEE + K+ E I++ Q +
Sbjct: 1133 ---QLECEKYKSVLAETEGILQKLQRSVEQEENKWKVKVDESHKTIKQMQSSFTSSEQEL 1189
Query: 1070 LPVRKEDFDL------RSHVE 1084
+R E+ D+ R H+E
Sbjct: 1190 ERLRSENKDIENLRREREHLE 1210
Score = 46.2 bits (108), Expect = 2e-04
Identities = 67/328 (20%), Positives = 126/328 (38%), Gaps = 29/328 (8%)
Query: 409 LRERKSSISSISGRDDLMDYHRRQREERLREQEMERLERQRLETILSLCAEYTKPDSRLS 468
LRE+ + M + + + R+Q++E +E + E + L + + P S LS
Sbjct: 1032 LREKNWEAMEALASTEKMLQDKVNKTSKERQQQVEAVELEAKEVLKKLFPKVSVP-SNLS 1090
Query: 469 TGTTVEDVQKINKE-LEKLQLSDEESVFEEALMSPDTRY-----RCHRKDSLPDADLASC 522
G + +K KE + S+E V E L D + C + S+ LA
Sbjct: 1091 YGEWLHGFEKKAKECMAGTSGSEEVKVLEHKLKEADEMHTLLQLECEKYKSV----LAET 1146
Query: 523 GSLSQSSASFFTPRSTRNDELLSDLTRTPPPPSSTFPKASSESSYLSILPKTPEGISEEQ 582
+ Q + + + +T S+F + E L K E + E+
Sbjct: 1147 EGILQKLQRSVEQEENKWKVKVDESHKTIKQMQSSFTSSEQELERLRSENKDIENLRRER 1206
Query: 583 R--SQELAAMEETRIVILNNLEELKQKIKDINDQMDESFREL---DMECALLDGEQKSET 637
EL E R + + ELK + ++ ++D+S+ E + E LL +
Sbjct: 1207 EHLEMELEKAEMERSTYVTEVRELKDLLTELQKKLDDSYSEAVRQNEELNLLKAQLNETL 1266
Query: 638 TELMKEKEILD------HLNRKIAELEKNIVGEKTKDADLL-------DVESKHFEDLEF 684
T+L E+ H ++ EL ++ + + D ++ + ES E +
Sbjct: 1267 TKLRTEQNERQKVAGDLHKAQQSLELIQSKIVKAAGDTTVIENSDVSPETESSEKETMSV 1326
Query: 685 QQLEHESRLDEEKENLTQQLLREVAEYQ 712
+ ++L + + + QQL +E YQ
Sbjct: 1327 SLNQTVTQLQQLLQAVNQQLTKEKEHYQ 1354
>gi|41322923 plectin 1 isoform 11 [Homo sapiens]
Length = 4547
Score = 54.3 bits (129), Expect = 7e-07
Identities = 145/734 (19%), Positives = 282/734 (38%), Gaps = 81/734 (11%)
Query: 389 EFDEADLESLRQ-ASGTPQPALRERKSSISSISGRDDLMDYHRRQREERLREQEMERLER 447
E E +LE RQ A GT Q L + I + + + +++ +L E+E+ RL+R
Sbjct: 1688 ELAEQELEKQRQLAEGTAQQRLAAEQELIRLRA------ETEQGEQQRQLLEEELARLQR 1741
Query: 448 Q-------RLETILSLCAEYTKPDSRLSTGTTVEDVQKINKELEKLQLSDEESVFEEALM 500
+ R E L + + L++ E+ + E K +L E F E L
Sbjct: 1742 EAAAATQKRQELEAELAKVRAEMEVLLASKARAEEESRSTSEKSKQRLEAEAGRFRE-LA 1800
Query: 501 SPDTRYRCHRKDSLPDADLASCGSLSQSSASFFTPRSTRNDEL--LSDLTRTPPPPSSTF 558
R R +++ LA + Q + + ++L + + TR
Sbjct: 1801 EEAARLRALAEEAKRQRQLAEEDAARQRAEA----ERVLAEKLAAIGEATRLKTEAEIAL 1856
Query: 559 PKASSESSYLSILPKTPEGISEEQRSQELAAMEETRIVILNNLEELKQKIKDINDQMDES 618
+ +E+ L L + + + +R +E AA + ++EE +++ +D E
Sbjct: 1857 KEKEAENERLRRLAE--DEAFQRRRLEEQAAQHKA------DIEERLAQLRKASDSELER 1908
Query: 619 FRELDMECALLDGEQKSETTELMKEKEILDHLNRKIAELEKNIVGEKTKDADLL-DVESK 677
+ L +E L Q E E++ K + AELE + ++ D L E
Sbjct: 1909 QKGL-VEDTLRQRRQVEE--EILALKASFEKAAAGKAELELELGRIRSNAEDTLRSKEQA 1965
Query: 678 HFEDLEFQQL--EHESRLDEEKENLTQQLL--REVAEYQRNIVSRKEKISALKKQANHIV 733
E +QL E E R E +E + + L E A ++ + E++ A ++A +
Sbjct: 1966 ELEAARQRQLAAEEERRRREAEERVQKSLAAEEEAARQRKAALEEVERLKAKVEEARRLR 2025
Query: 734 QQAQREQDHFVK-------------EKNNLIMMLQREKENLCNLEKKYSSLSGGKGFPVN 780
++A++E ++ EK + + Q+E+E L+++ S L +G
Sbjct: 2026 ERAEQESARQLQLAQEAAQKRLQAEEKAHAFAVQQKEQELQQTLQQEQSVLDQLRGEAEA 2085
Query: 781 PNTLKEGY--ISVNEINEPCGNSTNLSPSTQFPADADAVATEPATAVLASQPQSKEHFRS 838
E V E + + + + A+ A A A A++ KE +
Sbjct: 2086 ARRAAEEAEEARVQAEREAAQSRRQVEEAERLKQSAEEQAQARAQAQAAAEKLRKEAEQE 2145
Query: 839 LEERKKQHKEGL---YLSDTLPRKKTTSSISPHFSSATMGRSITPKAHLPLGQSNSCGSV 895
R + + L +D K + A + + +T L L +++ ++
Sbjct: 2146 AARRAQAEQAALRQKQAADAEMEKHKKFAEQTLRQKAQVEQELTT-LRLQLEETDHQKNL 2204
Query: 896 LPPSLAAMAKDSESRRMLRGYNHQQMSEGHRQKSEFYN---RTASESNVYLNSFHYPDHS 952
L L + ++ R +++ Q E R +E+ +
Sbjct: 2205 LDEELQRLKAEATEAARQRSQVEEELFSVRVQMEELSKLKARIEAENRALILRDKDNTQR 2264
Query: 953 YKDQAFDTLSLDSSDSMETSISACSPDNISSASTSNIARIEEM-ERLLK---QAHAEKTR 1008
+ + + + + ++ S++A + + ++A+ + E++LK QA E TR
Sbjct: 2265 FLQEEAEKMKQVAEEAARLSVAAQEAARLRQLAEEDLAQQRALAEKMLKEKMQAVQEATR 2324
Query: 1009 LLESREREMEAKKRALEEEKRRREILEK---RLQEETSQRQKLIEKE------------- 1052
L E + K+ A E+ +R +E E+ +L EET Q+ +E E
Sbjct: 2325 LKAEAELLQQQKELAQEQARRLQEDKEQMAQQLAEETQGFQRTLEAERQRQLEMSAEAER 2384
Query: 1053 --VKIRERQRAQAR 1064
+++ E RAQAR
Sbjct: 2385 LKLRVAEMSRAQAR 2398
Score = 48.5 bits (114), Expect = 4e-05
Identities = 50/211 (23%), Positives = 100/211 (47%), Gaps = 28/211 (13%)
Query: 573 KTPEGISEEQRSQELAAMEETRIVILNNLEELKQKIKDINDQMDESFRELDMECALLDGE 632
K E I E+ ELA E ++ ++ LE +Q+ +++ E+ EL+ E L E
Sbjct: 2408 KQAEEIGEKLHRTELATQE--KVTLVQTLEIQRQQSDHDAERLREAIAELEREKEKLQQE 2465
Query: 633 QK-----SETTELMKEKEILDH--------LNRK--IAELEKNIVGEKTKDADLLDVESK 677
K SE + ++++++L L+ K + + E+ I EK K L E
Sbjct: 2466 AKLLQLKSEEMQTVQQEQLLQETQALQQSFLSEKDSLLQRERFIEQEKAKLEQLFQDEVA 2525
Query: 678 HFEDLEFQQLEHESRLDEEKENLTQQLLREVAEYQRNIVSRKEKISALKKQANHIVQQAQ 737
+ L +Q + ++++E+ Q+L+ + E +R +E + +++ + QQ +
Sbjct: 2526 KAQQLREEQQRQQQQMEQER----QRLVASMEEARRRQHEAEEGVRRKQEELQQLEQQ-R 2580
Query: 738 REQDHFVKEKNNLIMMLQREKENLCNLEKKY 768
R+Q+ + E+N QR +E L LE+++
Sbjct: 2581 RQQEELLAEEN------QRLREQLQLLEEQH 2605
Score = 45.1 bits (105), Expect = 4e-04
Identities = 176/972 (18%), Positives = 367/972 (37%), Gaps = 169/972 (17%)
Query: 200 SMPSSPKQARKMSIQDSLALQPKLTRHKELASENINLRTRKYSSSSLSHMGAYSRSLPRL 259
+MP + QA + ++ AL ++ RH E E ++++ ++ + Y L
Sbjct: 1235 AMPLADSQAVREQLRQEQALLEEIERHGEKVEE-----CQRFAKQYINAIKDYELQLV-T 1288
Query: 260 YRATENQLTPLSLPPRNSLGNSKRTKLGEKDLPHSVID-NDNYLNFSSLSSGALPY---- 314
Y+A QL P++ P + + + G + + +D +Y ++L+S + +
Sbjct: 1289 YKA---QLEPVASPAK-----KPKVQSGSESVIQEYVDLRTHYSELTTLTSQYIKFISET 1340
Query: 315 -------KTSASEGNPYVSSTLSVPASPRVARKMLLASTSSCASDDFDQASYVGTNPSHS 367
+ A + L+ + ++ L + + + +A +
Sbjct: 1341 LRRMEEEERLAEQQRAEERERLAEVEAALEKQRQLAEAHAQAKAQAEREAKELQQRMQEE 1400
Query: 368 LLAGESDRVFATRRNFSCGSV-----EFDEADLES-LRQASGTPQPALR----------E 411
++ E V A ++ S + EA++++ RQA + LR +
Sbjct: 1401 VVRREEAAVDAQQQKRSIQEELQQLRQSSEAEIQAKARQAEAAERSRLRIEEEIRVVRLQ 1460
Query: 412 RKSSISSISGRDDLMDYHRRQREE-----RLREQEMERLERQ-RLETILSLCAEYTKPDS 465
+++ G + + R + EE R ++E ERL RQ + E+ AE
Sbjct: 1461 LEATERQRGGAEGELQALRARAEEAEAQKRQAQEEAERLRRQVQDESQRKRQAEVELASR 1520
Query: 466 RLSTGTTVEDVQKINKELEKLQLSDEESVFEEALMSPDTRYRCHRKDSLPDADLASCGSL 525
+ + Q+ + LE+L+L EE+ E L + + +L A ++ L
Sbjct: 1521 VKAEAEAAREKQRALQALEELRLQAEEA--ERRLRQAEVERARQVQVALETAQRSAEAEL 1578
Query: 526 SQSSASFFTPRSTRNDELLSDLTRTPPPPSSTFPKASSESSYLSILPKTPEGISEEQRSQ 585
ASF E + L R S + ++++ E E+R+Q
Sbjct: 1579 QSKRASF--------AEKTAQLER------------SLQEEHVAVAQLREEA---ERRAQ 1615
Query: 586 ELAAMEETRIVILNNLEELKQKIKDINDQMDESFRELDMECALLDGEQKSETTELMKEKE 645
+ A E R EE +++++ + +E+ R L ++ + ++ E K+KE
Sbjct: 1616 QQAEAERAR-------EEAERELERWQLKANEALR-LRLQAEEVAQQKSLAQAEAEKQKE 1667
Query: 646 ILDHLNRKIAELEKNIVGEKTKDADLLDVESKHFEDLEFQQLEHESRLDEEKENLTQQLL 705
+ R+ + E+ V ++ L+ + + E + RL E+E + +
Sbjct: 1668 EAEREARRRGKAEEQAVRQRELAEQELEKQRQLAEGTA------QQRLAAEQELIRLRAE 1721
Query: 706 REVAEYQRNIVSRKEKISALKKQANHIVQQAQREQDHFVKEKNNLIMML----QREKENL 761
E E QR ++ +E+++ L+++A Q+ Q + K + + ++L + E+E+
Sbjct: 1722 TEQGEQQRQLL--EEELARLQREAAAATQKRQELEAELAKVRAEMEVLLASKARAEEESR 1779
Query: 762 CNLEKKYSSLSGGKGFPVNPNTLKEGYISVNEINEPCGNSTNLS--PSTQFPADADAVAT 819
EK L G L E + + E L+ + + A+A+ V
Sbjct: 1780 STSEKSKQRLEAEAG---RFRELAEEAARLRALAEEAKRQRQLAEEDAARQRAEAERVLA 1836
Query: 820 EPATAV-----------LASQPQSKEH-------------FRSLEERKKQHKEGL----- 850
E A+ +A + + E+ R LEE+ QHK +
Sbjct: 1837 EKLAAIGEATRLKTEAEIALKEKEAENERLRRLAEDEAFQRRRLEEQAAQHKADIEERLA 1896
Query: 851 ---------------YLSDTLPRKKTTS----SISPHFSSATMGRSITPKAHLPLGQSNS 891
+ DTL +++ ++ F A G++ + L LG+ S
Sbjct: 1897 QLRKASDSELERQKGLVEDTLRQRRQVEEEILALKASFEKAAAGKA---ELELELGRIRS 1953
Query: 892 CG---------SVLPPSLAAMAKDSESRRMLRGYNHQQMSEGHRQKSEFYNRTASESNVY 942
+ L + E RR Q S +++ + A E
Sbjct: 1954 NAEDTLRSKEQAELEAARQRQLAAEEERRRREAEERVQKSLAAEEEAARQRKAALEEVER 2013
Query: 943 LNSFHYPDHSYKDQAFDTLSLDSSDSMETSISACSPDNISSASTSNIARIEEMERLLKQA 1002
L + +++A +S+ ++ + A + + + ++ +++ E+ L+Q
Sbjct: 2014 LKAKVEEARRLRERA----EQESARQLQLAQEA-AQKRLQAEEKAHAFAVQQKEQELQQT 2068
Query: 1003 HAEKTRLLESREREMEAKKRALEEEKR-----RREILEKRLQEETSQRQK-LIEKEVKIR 1056
++ +L+ E EA +RA EE + RE + R Q E ++R K E++ + R
Sbjct: 2069 LQQEQSVLDQLRGEAEAARRAAEEAEEARVQAEREAAQSRRQVEEAERLKQSAEEQAQAR 2128
Query: 1057 ERQRAQARPLTR 1068
+ +A A L +
Sbjct: 2129 AQAQAAAEKLRK 2140
Score = 45.1 bits (105), Expect = 4e-04
Identities = 121/724 (16%), Positives = 272/724 (37%), Gaps = 90/724 (12%)
Query: 374 DRVFATRRNFSCGSVEFDEADLESLRQASGTPQPALRERKSSISSISGRDDLMDYHRRQR 433
+ + A + +F + E +LE R S + ++ + + R + RR+R
Sbjct: 1925 EEILALKASFEKAAAGKAELELELGRIRSNAEDTLRSKEQAELEAARQRQLAAEEERRRR 1984
Query: 434 EERLREQEMERLERQRLETILSLCAEYTKPDSRLSTGTTVEDVQKINKELEKLQLSDEES 493
E R Q+ SL AE R + +E+V+++ ++E+ + E +
Sbjct: 1985 EAEERVQK-------------SLAAEEEAARQRKA---ALEEVERLKAKVEEARRLRERA 2028
Query: 494 VFEEALMSPDTRYRCHRKDSLPDADLASCGSLSQSSASFFTPRSTRNDELLSDLTRTPPP 553
E A + ++ L + A ++ Q ++ + ++ + D R
Sbjct: 2029 EQESARQLQLAQEAAQKR--LQAEEKAHAFAVQQKEQEL--QQTLQQEQSVLDQLR---G 2081
Query: 554 PSSTFPKASSESSYLSILPKTPEGISEEQ--RSQELAAMEETRIVILNNLEELKQKIKDI 611
+ +A+ E+ + + S Q ++ L E + + +K++
Sbjct: 2082 EAEAARRAAEEAEEARVQAEREAAQSRRQVEEAERLKQSAEEQAQARAQAQAAAEKLRKE 2141
Query: 612 NDQMDESFRELDMECALLDGEQKSETTELMKEKEILDHLNRKIAELEKNIVGEKTKDADL 671
+Q E+ R E A L +Q ++ E+ K K+ + R+ A++E+ + +
Sbjct: 2142 AEQ--EAARRAQAEQAALRQKQAAD-AEMEKHKKFAEQTLRQKAQVEQELTTLR------ 2192
Query: 672 LDVESKHFEDLEFQQLEHESRLDEEKENLTQQLLREVAEYQRNIVSRKEKISALKKQANH 731
L+ ++ +H+ L +E+ Q+L E E R +E++ +++ Q
Sbjct: 2193 ----------LQLEETDHQKNLLDEE---LQRLKAEATEAARQRSQVEEELFSVRVQMEE 2239
Query: 732 IVQ-QAQREQDH---FVKEKNNLIMMLQREKENLCNLEKKYSSLSGGKGFPVNPNTLKEG 787
+ + +A+ E ++ +++K+N LQ E E + + ++ + LS L E
Sbjct: 2240 LSKLKARIEAENRALILRDKDNTQRFLQEEAEKMKQVAEEAARLSVAAQEAARLRQLAEE 2299
Query: 788 YIS---------VNEINEPCGNSTNLSPSTQFPADADAVATEPATAVLASQPQSKEHF-- 836
++ + E + +T L + +A E A + + Q +
Sbjct: 2300 DLAQQRALAEKMLKEKMQAVQEATRLKAEAELLQQQKELAQEQARRLQEDKEQMAQQLAE 2359
Query: 837 ------RSLEERKKQHKEGLYLSDTLPRKKTTSSISPHFSSATMGRSITPKAHLPLGQSN 890
R+LE +++ E ++ L K + +S + A K +G+
Sbjct: 2360 ETQGFQRTLEAERQRQLEMSAEAERL--KLRVAEMSRAQARAEEDAQRFRKQAEEIGEKL 2417
Query: 891 SCGSVLPPSLAAMAKDSESRRMLRGYNHQQMSEGHRQKSEFYNRTASESNVY------LN 944
+ + + E +R ++ +++ E + + E+ + +
Sbjct: 2418 HRTELATQEKVTLVQTLEIQRQQSDHDAERLREAIAELEREKEKLQQEAKLLQLKSEEMQ 2477
Query: 945 SFHYPDHSYKDQAFDTLSLDSSDSM----------ETSISACSPDNISSASTSNIARIEE 994
+ + QA L DS+ + + D ++ A EE
Sbjct: 2478 TVQQEQLLQETQALQQSFLSEKDSLLQRERFIEQEKAKLEQLFQDEVAKAQQLR----EE 2533
Query: 995 MERLLKQAHAEKTRLLESREREMEAKKRALEEEKRRREILEKRLQEETSQRQKLIEKEVK 1054
+R +Q E+ RL+ S E + A E +R++E L++ Q+ Q + L E+ +
Sbjct: 2534 QQRQQQQMEQERQRLVASMEEARRRQHEAEEGVRRKQEELQQLEQQRRQQEELLAEENQR 2593
Query: 1055 IRER 1058
+RE+
Sbjct: 2594 LREQ 2597
Score = 41.6 bits (96), Expect = 0.005
Identities = 130/723 (17%), Positives = 291/723 (40%), Gaps = 89/723 (12%)
Query: 392 EADLESLRQASGTPQPALRERKSSISSISGRDDLMDYHRRQRE----ERLREQEMERLER 447
EA+L+S R AS + A ER ++ + RR ++ ER RE+ LER
Sbjct: 1575 EAELQSKR-ASFAEKTAQLERSLQEEHVAVAQLREEAERRAQQQAEAERAREEAERELER 1633
Query: 448 QRLETI----LSLCAEYTKPDSRLSTGTTVEDVQKINKELEKLQLSDEESVFEEALMSPD 503
+L+ L L AE L+ + ++ +E + ++E++V + L +
Sbjct: 1634 WQLKANEALRLRLQAEEVAQQKSLAQAEAEKQKEEAEREARRRGKAEEQAVRQRELAEQE 1693
Query: 504 TRYRCHRKDSLPDADLASCGSLSQSSASFFTPRSTRNDELLSD-LTRTPPPPSSTFPKAS 562
+ + LA+ L + A T + + +LL + L R ++ K
Sbjct: 1694 LEKQRQLAEGTAQQRLAAEQELIRLRAE--TEQGEQQRQLLEEELARLQREAAAATQKRQ 1751
Query: 563 SESSYLSILPKTPEGISEEQRSQELAAMEETRIVILNNLEELKQKIKDINDQMDESFREL 622
+ L+ + E + + E EE+R + E+ KQ+++ + FREL
Sbjct: 1752 ELEAELAKVRAEMEVLLASKARAE----EESR----STSEKSKQRLEAEAGR----FREL 1799
Query: 623 DMECALLDGEQKSETTELMKEKEILDH-LNRKIAELEKNIVGEKTKDADLLDVESKHFED 681
E A L ++ E +++++ + R+ AE E+ + + + ++++
Sbjct: 1800 AEEAARL----RALAEEAKRQRQLAEEDAARQRAEAERVLAEKLAAIGEATRLKTEAEIA 1855
Query: 682 LEFQQLEHES--RLDEEKENLTQQLLREVAEYQRNIVSRKEKISALKKQANHIVQQAQRE 739
L+ ++ E+E RL E++ ++L + A+++ +I +E+++ L+K ++ +++ +
Sbjct: 1856 LKEKEAENERLRRLAEDEAFQRRRLEEQAAQHKADI---EERLAQLRKASDSELERQKGL 1912
Query: 740 QDHFVKEKNNLIMMLQREKENLCNLEKKYSSLSGGKGFPVNPNTLKEGYISVNEINEPCG 799
+ ++++ + +E + L+ + + GK E + + I
Sbjct: 1913 VEDTLRQRRQV-------EEEILALKASFEKAAAGKA---------ELELELGRIRSNAE 1956
Query: 800 NSTNLSPSTQFPADADA-VATEPATAVLASQPQSKEHFRSLEERKKQHKEGLYLSDTLPR 858
++ + A +A E ++ + ++ + EE +Q K L + L
Sbjct: 1957 DTLRSKEQAELEAARQRQLAAEEERRRREAEERVQKSLAAEEEAARQRKAALEEVERLKA 2016
Query: 859 KKTTSSISPHFSSATMGRSITPKAHLPLGQSNSCGSVLPPSLAAMAKDSESRRMLRGYNH 918
K + + R + + Q + A K+ E ++ L+
Sbjct: 2017 KVEEARRLRERAEQESARQL--QLAQEAAQKRLQAEEKAHAFAVQQKEQELQQTLQ--QE 2072
Query: 919 QQMSEGHRQKSEFYNRTASESNVYLNSFHYPDHSYKDQAFDTLSLDSSDSMETSISACSP 978
Q + + R ++E R A E+ + ++ A ++ ++ ++ S +
Sbjct: 2073 QSVLDQLRGEAEAARRAAEEAE------EARVQAEREAAQSRRQVEEAERLKQSAEEQAQ 2126
Query: 979 DNISSASTSNIARIEEMERLLKQAHAEKTRLLESR----------EREMEAKKRALEEEK 1028
+ + + E+L K+A E R ++ + EME K+ E+
Sbjct: 2127 ARAQAQAAA--------EKLRKEAEQEAARRAQAEQAALRQKQAADAEMEKHKKFAEQTL 2178
Query: 1029 RRREILEKRLQ------EETSQRQKLIEKEVKIRERQRAQARPLTRY-LPVRKEDFDLRS 1081
R++ +E+ L EET ++ L+++E+ +R +A+A R V +E F +R
Sbjct: 2179 RQKAQVEQELTTLRLQLEETDHQKNLLDEEL---QRLKAEATEAARQRSQVEEELFSVRV 2235
Query: 1082 HVE 1084
+E
Sbjct: 2236 QME 2238
Score = 34.3 bits (77), Expect = 0.74
Identities = 33/108 (30%), Positives = 51/108 (47%), Gaps = 17/108 (15%)
Query: 993 EEMERLLKQAHAEKTRLLESREREMEAKKRALEEEKRR--------REILE-----KRLQ 1039
+E+E L + AE LL S+ R E + E+ K+R RE+ E + L
Sbjct: 1751 QELEAELAKVRAEMEVLLASKARAEEESRSTSEKSKQRLEAEAGRFRELAEEAARLRALA 1810
Query: 1040 EETSQRQKLIEKEVKIRERQRAQA-RPLTRYLPVRKEDFDLRSHVETA 1086
EE ++++L E++ RQRA+A R L L E L++ E A
Sbjct: 1811 EEAKRQRQLAEEDA---ARQRAEAERVLAEKLAAIGEATRLKTEAEIA 1855
>gi|41322914 plectin 1 isoform 10 [Homo sapiens]
Length = 4551
Score = 54.3 bits (129), Expect = 7e-07
Identities = 145/734 (19%), Positives = 282/734 (38%), Gaps = 81/734 (11%)
Query: 389 EFDEADLESLRQ-ASGTPQPALRERKSSISSISGRDDLMDYHRRQREERLREQEMERLER 447
E E +LE RQ A GT Q L + I + + + +++ +L E+E+ RL+R
Sbjct: 1692 ELAEQELEKQRQLAEGTAQQRLAAEQELIRLRA------ETEQGEQQRQLLEEELARLQR 1745
Query: 448 Q-------RLETILSLCAEYTKPDSRLSTGTTVEDVQKINKELEKLQLSDEESVFEEALM 500
+ R E L + + L++ E+ + E K +L E F E L
Sbjct: 1746 EAAAATQKRQELEAELAKVRAEMEVLLASKARAEEESRSTSEKSKQRLEAEAGRFRE-LA 1804
Query: 501 SPDTRYRCHRKDSLPDADLASCGSLSQSSASFFTPRSTRNDEL--LSDLTRTPPPPSSTF 558
R R +++ LA + Q + + ++L + + TR
Sbjct: 1805 EEAARLRALAEEAKRQRQLAEEDAARQRAEA----ERVLAEKLAAIGEATRLKTEAEIAL 1860
Query: 559 PKASSESSYLSILPKTPEGISEEQRSQELAAMEETRIVILNNLEELKQKIKDINDQMDES 618
+ +E+ L L + + + +R +E AA + ++EE +++ +D E
Sbjct: 1861 KEKEAENERLRRLAE--DEAFQRRRLEEQAAQHKA------DIEERLAQLRKASDSELER 1912
Query: 619 FRELDMECALLDGEQKSETTELMKEKEILDHLNRKIAELEKNIVGEKTKDADLL-DVESK 677
+ L +E L Q E E++ K + AELE + ++ D L E
Sbjct: 1913 QKGL-VEDTLRQRRQVEE--EILALKASFEKAAAGKAELELELGRIRSNAEDTLRSKEQA 1969
Query: 678 HFEDLEFQQL--EHESRLDEEKENLTQQLL--REVAEYQRNIVSRKEKISALKKQANHIV 733
E +QL E E R E +E + + L E A ++ + E++ A ++A +
Sbjct: 1970 ELEAARQRQLAAEEERRRREAEERVQKSLAAEEEAARQRKAALEEVERLKAKVEEARRLR 2029
Query: 734 QQAQREQDHFVK-------------EKNNLIMMLQREKENLCNLEKKYSSLSGGKGFPVN 780
++A++E ++ EK + + Q+E+E L+++ S L +G
Sbjct: 2030 ERAEQESARQLQLAQEAAQKRLQAEEKAHAFAVQQKEQELQQTLQQEQSVLDQLRGEAEA 2089
Query: 781 PNTLKEGY--ISVNEINEPCGNSTNLSPSTQFPADADAVATEPATAVLASQPQSKEHFRS 838
E V E + + + + A+ A A A A++ KE +
Sbjct: 2090 ARRAAEEAEEARVQAEREAAQSRRQVEEAERLKQSAEEQAQARAQAQAAAEKLRKEAEQE 2149
Query: 839 LEERKKQHKEGL---YLSDTLPRKKTTSSISPHFSSATMGRSITPKAHLPLGQSNSCGSV 895
R + + L +D K + A + + +T L L +++ ++
Sbjct: 2150 AARRAQAEQAALRQKQAADAEMEKHKKFAEQTLRQKAQVEQELTT-LRLQLEETDHQKNL 2208
Query: 896 LPPSLAAMAKDSESRRMLRGYNHQQMSEGHRQKSEFYN---RTASESNVYLNSFHYPDHS 952
L L + ++ R +++ Q E R +E+ +
Sbjct: 2209 LDEELQRLKAEATEAARQRSQVEEELFSVRVQMEELSKLKARIEAENRALILRDKDNTQR 2268
Query: 953 YKDQAFDTLSLDSSDSMETSISACSPDNISSASTSNIARIEEM-ERLLK---QAHAEKTR 1008
+ + + + + ++ S++A + + ++A+ + E++LK QA E TR
Sbjct: 2269 FLQEEAEKMKQVAEEAARLSVAAQEAARLRQLAEEDLAQQRALAEKMLKEKMQAVQEATR 2328
Query: 1009 LLESREREMEAKKRALEEEKRRREILEK---RLQEETSQRQKLIEKE------------- 1052
L E + K+ A E+ +R +E E+ +L EET Q+ +E E
Sbjct: 2329 LKAEAELLQQQKELAQEQARRLQEDKEQMAQQLAEETQGFQRTLEAERQRQLEMSAEAER 2388
Query: 1053 --VKIRERQRAQAR 1064
+++ E RAQAR
Sbjct: 2389 LKLRVAEMSRAQAR 2402
Score = 48.5 bits (114), Expect = 4e-05
Identities = 50/211 (23%), Positives = 100/211 (47%), Gaps = 28/211 (13%)
Query: 573 KTPEGISEEQRSQELAAMEETRIVILNNLEELKQKIKDINDQMDESFRELDMECALLDGE 632
K E I E+ ELA E ++ ++ LE +Q+ +++ E+ EL+ E L E
Sbjct: 2412 KQAEEIGEKLHRTELATQE--KVTLVQTLEIQRQQSDHDAERLREAIAELEREKEKLQQE 2469
Query: 633 QK-----SETTELMKEKEILDH--------LNRK--IAELEKNIVGEKTKDADLLDVESK 677
K SE + ++++++L L+ K + + E+ I EK K L E
Sbjct: 2470 AKLLQLKSEEMQTVQQEQLLQETQALQQSFLSEKDSLLQRERFIEQEKAKLEQLFQDEVA 2529
Query: 678 HFEDLEFQQLEHESRLDEEKENLTQQLLREVAEYQRNIVSRKEKISALKKQANHIVQQAQ 737
+ L +Q + ++++E+ Q+L+ + E +R +E + +++ + QQ +
Sbjct: 2530 KAQQLREEQQRQQQQMEQER----QRLVASMEEARRRQHEAEEGVRRKQEELQQLEQQ-R 2584
Query: 738 REQDHFVKEKNNLIMMLQREKENLCNLEKKY 768
R+Q+ + E+N QR +E L LE+++
Sbjct: 2585 RQQEELLAEEN------QRLREQLQLLEEQH 2609
Score = 45.1 bits (105), Expect = 4e-04
Identities = 176/972 (18%), Positives = 367/972 (37%), Gaps = 169/972 (17%)
Query: 200 SMPSSPKQARKMSIQDSLALQPKLTRHKELASENINLRTRKYSSSSLSHMGAYSRSLPRL 259
+MP + QA + ++ AL ++ RH E E ++++ ++ + Y L
Sbjct: 1239 AMPLADSQAVREQLRQEQALLEEIERHGEKVEE-----CQRFAKQYINAIKDYELQLV-T 1292
Query: 260 YRATENQLTPLSLPPRNSLGNSKRTKLGEKDLPHSVID-NDNYLNFSSLSSGALPY---- 314
Y+A QL P++ P + + + G + + +D +Y ++L+S + +
Sbjct: 1293 YKA---QLEPVASPAK-----KPKVQSGSESVIQEYVDLRTHYSELTTLTSQYIKFISET 1344
Query: 315 -------KTSASEGNPYVSSTLSVPASPRVARKMLLASTSSCASDDFDQASYVGTNPSHS 367
+ A + L+ + ++ L + + + +A +
Sbjct: 1345 LRRMEEEERLAEQQRAEERERLAEVEAALEKQRQLAEAHAQAKAQAEREAKELQQRMQEE 1404
Query: 368 LLAGESDRVFATRRNFSCGSV-----EFDEADLES-LRQASGTPQPALR----------E 411
++ E V A ++ S + EA++++ RQA + LR +
Sbjct: 1405 VVRREEAAVDAQQQKRSIQEELQQLRQSSEAEIQAKARQAEAAERSRLRIEEEIRVVRLQ 1464
Query: 412 RKSSISSISGRDDLMDYHRRQREE-----RLREQEMERLERQ-RLETILSLCAEYTKPDS 465
+++ G + + R + EE R ++E ERL RQ + E+ AE
Sbjct: 1465 LEATERQRGGAEGELQALRARAEEAEAQKRQAQEEAERLRRQVQDESQRKRQAEVELASR 1524
Query: 466 RLSTGTTVEDVQKINKELEKLQLSDEESVFEEALMSPDTRYRCHRKDSLPDADLASCGSL 525
+ + Q+ + LE+L+L EE+ E L + + +L A ++ L
Sbjct: 1525 VKAEAEAAREKQRALQALEELRLQAEEA--ERRLRQAEVERARQVQVALETAQRSAEAEL 1582
Query: 526 SQSSASFFTPRSTRNDELLSDLTRTPPPPSSTFPKASSESSYLSILPKTPEGISEEQRSQ 585
ASF E + L R S + ++++ E E+R+Q
Sbjct: 1583 QSKRASF--------AEKTAQLER------------SLQEEHVAVAQLREEA---ERRAQ 1619
Query: 586 ELAAMEETRIVILNNLEELKQKIKDINDQMDESFRELDMECALLDGEQKSETTELMKEKE 645
+ A E R EE +++++ + +E+ R L ++ + ++ E K+KE
Sbjct: 1620 QQAEAERAR-------EEAERELERWQLKANEALR-LRLQAEEVAQQKSLAQAEAEKQKE 1671
Query: 646 ILDHLNRKIAELEKNIVGEKTKDADLLDVESKHFEDLEFQQLEHESRLDEEKENLTQQLL 705
+ R+ + E+ V ++ L+ + + E + RL E+E + +
Sbjct: 1672 EAEREARRRGKAEEQAVRQRELAEQELEKQRQLAEGTA------QQRLAAEQELIRLRAE 1725
Query: 706 REVAEYQRNIVSRKEKISALKKQANHIVQQAQREQDHFVKEKNNLIMML----QREKENL 761
E E QR ++ +E+++ L+++A Q+ Q + K + + ++L + E+E+
Sbjct: 1726 TEQGEQQRQLL--EEELARLQREAAAATQKRQELEAELAKVRAEMEVLLASKARAEEESR 1783
Query: 762 CNLEKKYSSLSGGKGFPVNPNTLKEGYISVNEINEPCGNSTNLS--PSTQFPADADAVAT 819
EK L G L E + + E L+ + + A+A+ V
Sbjct: 1784 STSEKSKQRLEAEAG---RFRELAEEAARLRALAEEAKRQRQLAEEDAARQRAEAERVLA 1840
Query: 820 EPATAV-----------LASQPQSKEH-------------FRSLEERKKQHKEGL----- 850
E A+ +A + + E+ R LEE+ QHK +
Sbjct: 1841 EKLAAIGEATRLKTEAEIALKEKEAENERLRRLAEDEAFQRRRLEEQAAQHKADIEERLA 1900
Query: 851 ---------------YLSDTLPRKKTTS----SISPHFSSATMGRSITPKAHLPLGQSNS 891
+ DTL +++ ++ F A G++ + L LG+ S
Sbjct: 1901 QLRKASDSELERQKGLVEDTLRQRRQVEEEILALKASFEKAAAGKA---ELELELGRIRS 1957
Query: 892 CG---------SVLPPSLAAMAKDSESRRMLRGYNHQQMSEGHRQKSEFYNRTASESNVY 942
+ L + E RR Q S +++ + A E
Sbjct: 1958 NAEDTLRSKEQAELEAARQRQLAAEEERRRREAEERVQKSLAAEEEAARQRKAALEEVER 2017
Query: 943 LNSFHYPDHSYKDQAFDTLSLDSSDSMETSISACSPDNISSASTSNIARIEEMERLLKQA 1002
L + +++A +S+ ++ + A + + + ++ +++ E+ L+Q
Sbjct: 2018 LKAKVEEARRLRERA----EQESARQLQLAQEA-AQKRLQAEEKAHAFAVQQKEQELQQT 2072
Query: 1003 HAEKTRLLESREREMEAKKRALEEEKR-----RREILEKRLQEETSQRQK-LIEKEVKIR 1056
++ +L+ E EA +RA EE + RE + R Q E ++R K E++ + R
Sbjct: 2073 LQQEQSVLDQLRGEAEAARRAAEEAEEARVQAEREAAQSRRQVEEAERLKQSAEEQAQAR 2132
Query: 1057 ERQRAQARPLTR 1068
+ +A A L +
Sbjct: 2133 AQAQAAAEKLRK 2144
Score = 45.1 bits (105), Expect = 4e-04
Identities = 121/724 (16%), Positives = 272/724 (37%), Gaps = 90/724 (12%)
Query: 374 DRVFATRRNFSCGSVEFDEADLESLRQASGTPQPALRERKSSISSISGRDDLMDYHRRQR 433
+ + A + +F + E +LE R S + ++ + + R + RR+R
Sbjct: 1929 EEILALKASFEKAAAGKAELELELGRIRSNAEDTLRSKEQAELEAARQRQLAAEEERRRR 1988
Query: 434 EERLREQEMERLERQRLETILSLCAEYTKPDSRLSTGTTVEDVQKINKELEKLQLSDEES 493
E R Q+ SL AE R + +E+V+++ ++E+ + E +
Sbjct: 1989 EAEERVQK-------------SLAAEEEAARQRKA---ALEEVERLKAKVEEARRLRERA 2032
Query: 494 VFEEALMSPDTRYRCHRKDSLPDADLASCGSLSQSSASFFTPRSTRNDELLSDLTRTPPP 553
E A + ++ L + A ++ Q ++ + ++ + D R
Sbjct: 2033 EQESARQLQLAQEAAQKR--LQAEEKAHAFAVQQKEQEL--QQTLQQEQSVLDQLR---G 2085
Query: 554 PSSTFPKASSESSYLSILPKTPEGISEEQ--RSQELAAMEETRIVILNNLEELKQKIKDI 611
+ +A+ E+ + + S Q ++ L E + + +K++
Sbjct: 2086 EAEAARRAAEEAEEARVQAEREAAQSRRQVEEAERLKQSAEEQAQARAQAQAAAEKLRKE 2145
Query: 612 NDQMDESFRELDMECALLDGEQKSETTELMKEKEILDHLNRKIAELEKNIVGEKTKDADL 671
+Q E+ R E A L +Q ++ E+ K K+ + R+ A++E+ + +
Sbjct: 2146 AEQ--EAARRAQAEQAALRQKQAAD-AEMEKHKKFAEQTLRQKAQVEQELTTLR------ 2196
Query: 672 LDVESKHFEDLEFQQLEHESRLDEEKENLTQQLLREVAEYQRNIVSRKEKISALKKQANH 731
L+ ++ +H+ L +E+ Q+L E E R +E++ +++ Q
Sbjct: 2197 ----------LQLEETDHQKNLLDEE---LQRLKAEATEAARQRSQVEEELFSVRVQMEE 2243
Query: 732 IVQ-QAQREQDH---FVKEKNNLIMMLQREKENLCNLEKKYSSLSGGKGFPVNPNTLKEG 787
+ + +A+ E ++ +++K+N LQ E E + + ++ + LS L E
Sbjct: 2244 LSKLKARIEAENRALILRDKDNTQRFLQEEAEKMKQVAEEAARLSVAAQEAARLRQLAEE 2303
Query: 788 YIS---------VNEINEPCGNSTNLSPSTQFPADADAVATEPATAVLASQPQSKEHF-- 836
++ + E + +T L + +A E A + + Q +
Sbjct: 2304 DLAQQRALAEKMLKEKMQAVQEATRLKAEAELLQQQKELAQEQARRLQEDKEQMAQQLAE 2363
Query: 837 ------RSLEERKKQHKEGLYLSDTLPRKKTTSSISPHFSSATMGRSITPKAHLPLGQSN 890
R+LE +++ E ++ L K + +S + A K +G+
Sbjct: 2364 ETQGFQRTLEAERQRQLEMSAEAERL--KLRVAEMSRAQARAEEDAQRFRKQAEEIGEKL 2421
Query: 891 SCGSVLPPSLAAMAKDSESRRMLRGYNHQQMSEGHRQKSEFYNRTASESNVY------LN 944
+ + + E +R ++ +++ E + + E+ + +
Sbjct: 2422 HRTELATQEKVTLVQTLEIQRQQSDHDAERLREAIAELEREKEKLQQEAKLLQLKSEEMQ 2481
Query: 945 SFHYPDHSYKDQAFDTLSLDSSDSM----------ETSISACSPDNISSASTSNIARIEE 994
+ + QA L DS+ + + D ++ A EE
Sbjct: 2482 TVQQEQLLQETQALQQSFLSEKDSLLQRERFIEQEKAKLEQLFQDEVAKAQQLR----EE 2537
Query: 995 MERLLKQAHAEKTRLLESREREMEAKKRALEEEKRRREILEKRLQEETSQRQKLIEKEVK 1054
+R +Q E+ RL+ S E + A E +R++E L++ Q+ Q + L E+ +
Sbjct: 2538 QQRQQQQMEQERQRLVASMEEARRRQHEAEEGVRRKQEELQQLEQQRRQQEELLAEENQR 2597
Query: 1055 IRER 1058
+RE+
Sbjct: 2598 LREQ 2601
Score = 41.6 bits (96), Expect = 0.005
Identities = 130/723 (17%), Positives = 291/723 (40%), Gaps = 89/723 (12%)
Query: 392 EADLESLRQASGTPQPALRERKSSISSISGRDDLMDYHRRQRE----ERLREQEMERLER 447
EA+L+S R AS + A ER ++ + RR ++ ER RE+ LER
Sbjct: 1579 EAELQSKR-ASFAEKTAQLERSLQEEHVAVAQLREEAERRAQQQAEAERAREEAERELER 1637
Query: 448 QRLETI----LSLCAEYTKPDSRLSTGTTVEDVQKINKELEKLQLSDEESVFEEALMSPD 503
+L+ L L AE L+ + ++ +E + ++E++V + L +
Sbjct: 1638 WQLKANEALRLRLQAEEVAQQKSLAQAEAEKQKEEAEREARRRGKAEEQAVRQRELAEQE 1697
Query: 504 TRYRCHRKDSLPDADLASCGSLSQSSASFFTPRSTRNDELLSD-LTRTPPPPSSTFPKAS 562
+ + LA+ L + A T + + +LL + L R ++ K
Sbjct: 1698 LEKQRQLAEGTAQQRLAAEQELIRLRAE--TEQGEQQRQLLEEELARLQREAAAATQKRQ 1755
Query: 563 SESSYLSILPKTPEGISEEQRSQELAAMEETRIVILNNLEELKQKIKDINDQMDESFREL 622
+ L+ + E + + E EE+R + E+ KQ+++ + FREL
Sbjct: 1756 ELEAELAKVRAEMEVLLASKARAE----EESR----STSEKSKQRLEAEAGR----FREL 1803
Query: 623 DMECALLDGEQKSETTELMKEKEILDH-LNRKIAELEKNIVGEKTKDADLLDVESKHFED 681
E A L ++ E +++++ + R+ AE E+ + + + ++++
Sbjct: 1804 AEEAARL----RALAEEAKRQRQLAEEDAARQRAEAERVLAEKLAAIGEATRLKTEAEIA 1859
Query: 682 LEFQQLEHES--RLDEEKENLTQQLLREVAEYQRNIVSRKEKISALKKQANHIVQQAQRE 739
L+ ++ E+E RL E++ ++L + A+++ +I +E+++ L+K ++ +++ +
Sbjct: 1860 LKEKEAENERLRRLAEDEAFQRRRLEEQAAQHKADI---EERLAQLRKASDSELERQKGL 1916
Query: 740 QDHFVKEKNNLIMMLQREKENLCNLEKKYSSLSGGKGFPVNPNTLKEGYISVNEINEPCG 799
+ ++++ + +E + L+ + + GK E + + I
Sbjct: 1917 VEDTLRQRRQV-------EEEILALKASFEKAAAGKA---------ELELELGRIRSNAE 1960
Query: 800 NSTNLSPSTQFPADADA-VATEPATAVLASQPQSKEHFRSLEERKKQHKEGLYLSDTLPR 858
++ + A +A E ++ + ++ + EE +Q K L + L
Sbjct: 1961 DTLRSKEQAELEAARQRQLAAEEERRRREAEERVQKSLAAEEEAARQRKAALEEVERLKA 2020
Query: 859 KKTTSSISPHFSSATMGRSITPKAHLPLGQSNSCGSVLPPSLAAMAKDSESRRMLRGYNH 918
K + + R + + Q + A K+ E ++ L+
Sbjct: 2021 KVEEARRLRERAEQESARQL--QLAQEAAQKRLQAEEKAHAFAVQQKEQELQQTLQ--QE 2076
Query: 919 QQMSEGHRQKSEFYNRTASESNVYLNSFHYPDHSYKDQAFDTLSLDSSDSMETSISACSP 978
Q + + R ++E R A E+ + ++ A ++ ++ ++ S +
Sbjct: 2077 QSVLDQLRGEAEAARRAAEEAE------EARVQAEREAAQSRRQVEEAERLKQSAEEQAQ 2130
Query: 979 DNISSASTSNIARIEEMERLLKQAHAEKTRLLESR----------EREMEAKKRALEEEK 1028
+ + + E+L K+A E R ++ + EME K+ E+
Sbjct: 2131 ARAQAQAAA--------EKLRKEAEQEAARRAQAEQAALRQKQAADAEMEKHKKFAEQTL 2182
Query: 1029 RRREILEKRLQ------EETSQRQKLIEKEVKIRERQRAQARPLTRY-LPVRKEDFDLRS 1081
R++ +E+ L EET ++ L+++E+ +R +A+A R V +E F +R
Sbjct: 2183 RQKAQVEQELTTLRLQLEETDHQKNLLDEEL---QRLKAEATEAARQRSQVEEELFSVRV 2239
Query: 1082 HVE 1084
+E
Sbjct: 2240 QME 2242
Score = 34.3 bits (77), Expect = 0.74
Identities = 33/108 (30%), Positives = 51/108 (47%), Gaps = 17/108 (15%)
Query: 993 EEMERLLKQAHAEKTRLLESREREMEAKKRALEEEKRR--------REILE-----KRLQ 1039
+E+E L + AE LL S+ R E + E+ K+R RE+ E + L
Sbjct: 1755 QELEAELAKVRAEMEVLLASKARAEEESRSTSEKSKQRLEAEAGRFRELAEEAARLRALA 1814
Query: 1040 EETSQRQKLIEKEVKIRERQRAQA-RPLTRYLPVRKEDFDLRSHVETA 1086
EE ++++L E++ RQRA+A R L L E L++ E A
Sbjct: 1815 EEAKRQRQLAEEDA---ARQRAEAERVLAEKLAAIGEATRLKTEAEIA 1859
>gi|41322919 plectin 1 isoform 8 [Homo sapiens]
Length = 4547
Score = 54.3 bits (129), Expect = 7e-07
Identities = 145/734 (19%), Positives = 282/734 (38%), Gaps = 81/734 (11%)
Query: 389 EFDEADLESLRQ-ASGTPQPALRERKSSISSISGRDDLMDYHRRQREERLREQEMERLER 447
E E +LE RQ A GT Q L + I + + + +++ +L E+E+ RL+R
Sbjct: 1688 ELAEQELEKQRQLAEGTAQQRLAAEQELIRLRA------ETEQGEQQRQLLEEELARLQR 1741
Query: 448 Q-------RLETILSLCAEYTKPDSRLSTGTTVEDVQKINKELEKLQLSDEESVFEEALM 500
+ R E L + + L++ E+ + E K +L E F E L
Sbjct: 1742 EAAAATQKRQELEAELAKVRAEMEVLLASKARAEEESRSTSEKSKQRLEAEAGRFRE-LA 1800
Query: 501 SPDTRYRCHRKDSLPDADLASCGSLSQSSASFFTPRSTRNDEL--LSDLTRTPPPPSSTF 558
R R +++ LA + Q + + ++L + + TR
Sbjct: 1801 EEAARLRALAEEAKRQRQLAEEDAARQRAEA----ERVLAEKLAAIGEATRLKTEAEIAL 1856
Query: 559 PKASSESSYLSILPKTPEGISEEQRSQELAAMEETRIVILNNLEELKQKIKDINDQMDES 618
+ +E+ L L + + + +R +E AA + ++EE +++ +D E
Sbjct: 1857 KEKEAENERLRRLAE--DEAFQRRRLEEQAAQHKA------DIEERLAQLRKASDSELER 1908
Query: 619 FRELDMECALLDGEQKSETTELMKEKEILDHLNRKIAELEKNIVGEKTKDADLL-DVESK 677
+ L +E L Q E E++ K + AELE + ++ D L E
Sbjct: 1909 QKGL-VEDTLRQRRQVEE--EILALKASFEKAAAGKAELELELGRIRSNAEDTLRSKEQA 1965
Query: 678 HFEDLEFQQL--EHESRLDEEKENLTQQLL--REVAEYQRNIVSRKEKISALKKQANHIV 733
E +QL E E R E +E + + L E A ++ + E++ A ++A +
Sbjct: 1966 ELEAARQRQLAAEEERRRREAEERVQKSLAAEEEAARQRKAALEEVERLKAKVEEARRLR 2025
Query: 734 QQAQREQDHFVK-------------EKNNLIMMLQREKENLCNLEKKYSSLSGGKGFPVN 780
++A++E ++ EK + + Q+E+E L+++ S L +G
Sbjct: 2026 ERAEQESARQLQLAQEAAQKRLQAEEKAHAFAVQQKEQELQQTLQQEQSVLDQLRGEAEA 2085
Query: 781 PNTLKEGY--ISVNEINEPCGNSTNLSPSTQFPADADAVATEPATAVLASQPQSKEHFRS 838
E V E + + + + A+ A A A A++ KE +
Sbjct: 2086 ARRAAEEAEEARVQAEREAAQSRRQVEEAERLKQSAEEQAQARAQAQAAAEKLRKEAEQE 2145
Query: 839 LEERKKQHKEGL---YLSDTLPRKKTTSSISPHFSSATMGRSITPKAHLPLGQSNSCGSV 895
R + + L +D K + A + + +T L L +++ ++
Sbjct: 2146 AARRAQAEQAALRQKQAADAEMEKHKKFAEQTLRQKAQVEQELTT-LRLQLEETDHQKNL 2204
Query: 896 LPPSLAAMAKDSESRRMLRGYNHQQMSEGHRQKSEFYN---RTASESNVYLNSFHYPDHS 952
L L + ++ R +++ Q E R +E+ +
Sbjct: 2205 LDEELQRLKAEATEAARQRSQVEEELFSVRVQMEELSKLKARIEAENRALILRDKDNTQR 2264
Query: 953 YKDQAFDTLSLDSSDSMETSISACSPDNISSASTSNIARIEEM-ERLLK---QAHAEKTR 1008
+ + + + + ++ S++A + + ++A+ + E++LK QA E TR
Sbjct: 2265 FLQEEAEKMKQVAEEAARLSVAAQEAARLRQLAEEDLAQQRALAEKMLKEKMQAVQEATR 2324
Query: 1009 LLESREREMEAKKRALEEEKRRREILEK---RLQEETSQRQKLIEKE------------- 1052
L E + K+ A E+ +R +E E+ +L EET Q+ +E E
Sbjct: 2325 LKAEAELLQQQKELAQEQARRLQEDKEQMAQQLAEETQGFQRTLEAERQRQLEMSAEAER 2384
Query: 1053 --VKIRERQRAQAR 1064
+++ E RAQAR
Sbjct: 2385 LKLRVAEMSRAQAR 2398
Score = 48.5 bits (114), Expect = 4e-05
Identities = 50/211 (23%), Positives = 100/211 (47%), Gaps = 28/211 (13%)
Query: 573 KTPEGISEEQRSQELAAMEETRIVILNNLEELKQKIKDINDQMDESFRELDMECALLDGE 632
K E I E+ ELA E ++ ++ LE +Q+ +++ E+ EL+ E L E
Sbjct: 2408 KQAEEIGEKLHRTELATQE--KVTLVQTLEIQRQQSDHDAERLREAIAELEREKEKLQQE 2465
Query: 633 QK-----SETTELMKEKEILDH--------LNRK--IAELEKNIVGEKTKDADLLDVESK 677
K SE + ++++++L L+ K + + E+ I EK K L E
Sbjct: 2466 AKLLQLKSEEMQTVQQEQLLQETQALQQSFLSEKDSLLQRERFIEQEKAKLEQLFQDEVA 2525
Query: 678 HFEDLEFQQLEHESRLDEEKENLTQQLLREVAEYQRNIVSRKEKISALKKQANHIVQQAQ 737
+ L +Q + ++++E+ Q+L+ + E +R +E + +++ + QQ +
Sbjct: 2526 KAQQLREEQQRQQQQMEQER----QRLVASMEEARRRQHEAEEGVRRKQEELQQLEQQ-R 2580
Query: 738 REQDHFVKEKNNLIMMLQREKENLCNLEKKY 768
R+Q+ + E+N QR +E L LE+++
Sbjct: 2581 RQQEELLAEEN------QRLREQLQLLEEQH 2605
Score = 45.1 bits (105), Expect = 4e-04
Identities = 176/972 (18%), Positives = 367/972 (37%), Gaps = 169/972 (17%)
Query: 200 SMPSSPKQARKMSIQDSLALQPKLTRHKELASENINLRTRKYSSSSLSHMGAYSRSLPRL 259
+MP + QA + ++ AL ++ RH E E ++++ ++ + Y L
Sbjct: 1235 AMPLADSQAVREQLRQEQALLEEIERHGEKVEE-----CQRFAKQYINAIKDYELQLV-T 1288
Query: 260 YRATENQLTPLSLPPRNSLGNSKRTKLGEKDLPHSVID-NDNYLNFSSLSSGALPY---- 314
Y+A QL P++ P + + + G + + +D +Y ++L+S + +
Sbjct: 1289 YKA---QLEPVASPAK-----KPKVQSGSESVIQEYVDLRTHYSELTTLTSQYIKFISET 1340
Query: 315 -------KTSASEGNPYVSSTLSVPASPRVARKMLLASTSSCASDDFDQASYVGTNPSHS 367
+ A + L+ + ++ L + + + +A +
Sbjct: 1341 LRRMEEEERLAEQQRAEERERLAEVEAALEKQRQLAEAHAQAKAQAEREAKELQQRMQEE 1400
Query: 368 LLAGESDRVFATRRNFSCGSV-----EFDEADLES-LRQASGTPQPALR----------E 411
++ E V A ++ S + EA++++ RQA + LR +
Sbjct: 1401 VVRREEAAVDAQQQKRSIQEELQQLRQSSEAEIQAKARQAEAAERSRLRIEEEIRVVRLQ 1460
Query: 412 RKSSISSISGRDDLMDYHRRQREE-----RLREQEMERLERQ-RLETILSLCAEYTKPDS 465
+++ G + + R + EE R ++E ERL RQ + E+ AE
Sbjct: 1461 LEATERQRGGAEGELQALRARAEEAEAQKRQAQEEAERLRRQVQDESQRKRQAEVELASR 1520
Query: 466 RLSTGTTVEDVQKINKELEKLQLSDEESVFEEALMSPDTRYRCHRKDSLPDADLASCGSL 525
+ + Q+ + LE+L+L EE+ E L + + +L A ++ L
Sbjct: 1521 VKAEAEAAREKQRALQALEELRLQAEEA--ERRLRQAEVERARQVQVALETAQRSAEAEL 1578
Query: 526 SQSSASFFTPRSTRNDELLSDLTRTPPPPSSTFPKASSESSYLSILPKTPEGISEEQRSQ 585
ASF E + L R S + ++++ E E+R+Q
Sbjct: 1579 QSKRASF--------AEKTAQLER------------SLQEEHVAVAQLREEA---ERRAQ 1615
Query: 586 ELAAMEETRIVILNNLEELKQKIKDINDQMDESFRELDMECALLDGEQKSETTELMKEKE 645
+ A E R EE +++++ + +E+ R L ++ + ++ E K+KE
Sbjct: 1616 QQAEAERAR-------EEAERELERWQLKANEALR-LRLQAEEVAQQKSLAQAEAEKQKE 1667
Query: 646 ILDHLNRKIAELEKNIVGEKTKDADLLDVESKHFEDLEFQQLEHESRLDEEKENLTQQLL 705
+ R+ + E+ V ++ L+ + + E + RL E+E + +
Sbjct: 1668 EAEREARRRGKAEEQAVRQRELAEQELEKQRQLAEGTA------QQRLAAEQELIRLRAE 1721
Query: 706 REVAEYQRNIVSRKEKISALKKQANHIVQQAQREQDHFVKEKNNLIMML----QREKENL 761
E E QR ++ +E+++ L+++A Q+ Q + K + + ++L + E+E+
Sbjct: 1722 TEQGEQQRQLL--EEELARLQREAAAATQKRQELEAELAKVRAEMEVLLASKARAEEESR 1779
Query: 762 CNLEKKYSSLSGGKGFPVNPNTLKEGYISVNEINEPCGNSTNLS--PSTQFPADADAVAT 819
EK L G L E + + E L+ + + A+A+ V
Sbjct: 1780 STSEKSKQRLEAEAG---RFRELAEEAARLRALAEEAKRQRQLAEEDAARQRAEAERVLA 1836
Query: 820 EPATAV-----------LASQPQSKEH-------------FRSLEERKKQHKEGL----- 850
E A+ +A + + E+ R LEE+ QHK +
Sbjct: 1837 EKLAAIGEATRLKTEAEIALKEKEAENERLRRLAEDEAFQRRRLEEQAAQHKADIEERLA 1896
Query: 851 ---------------YLSDTLPRKKTTS----SISPHFSSATMGRSITPKAHLPLGQSNS 891
+ DTL +++ ++ F A G++ + L LG+ S
Sbjct: 1897 QLRKASDSELERQKGLVEDTLRQRRQVEEEILALKASFEKAAAGKA---ELELELGRIRS 1953
Query: 892 CG---------SVLPPSLAAMAKDSESRRMLRGYNHQQMSEGHRQKSEFYNRTASESNVY 942
+ L + E RR Q S +++ + A E
Sbjct: 1954 NAEDTLRSKEQAELEAARQRQLAAEEERRRREAEERVQKSLAAEEEAARQRKAALEEVER 2013
Query: 943 LNSFHYPDHSYKDQAFDTLSLDSSDSMETSISACSPDNISSASTSNIARIEEMERLLKQA 1002
L + +++A +S+ ++ + A + + + ++ +++ E+ L+Q
Sbjct: 2014 LKAKVEEARRLRERA----EQESARQLQLAQEA-AQKRLQAEEKAHAFAVQQKEQELQQT 2068
Query: 1003 HAEKTRLLESREREMEAKKRALEEEKR-----RREILEKRLQEETSQRQK-LIEKEVKIR 1056
++ +L+ E EA +RA EE + RE + R Q E ++R K E++ + R
Sbjct: 2069 LQQEQSVLDQLRGEAEAARRAAEEAEEARVQAEREAAQSRRQVEEAERLKQSAEEQAQAR 2128
Query: 1057 ERQRAQARPLTR 1068
+ +A A L +
Sbjct: 2129 AQAQAAAEKLRK 2140
Score = 45.1 bits (105), Expect = 4e-04
Identities = 121/724 (16%), Positives = 272/724 (37%), Gaps = 90/724 (12%)
Query: 374 DRVFATRRNFSCGSVEFDEADLESLRQASGTPQPALRERKSSISSISGRDDLMDYHRRQR 433
+ + A + +F + E +LE R S + ++ + + R + RR+R
Sbjct: 1925 EEILALKASFEKAAAGKAELELELGRIRSNAEDTLRSKEQAELEAARQRQLAAEEERRRR 1984
Query: 434 EERLREQEMERLERQRLETILSLCAEYTKPDSRLSTGTTVEDVQKINKELEKLQLSDEES 493
E R Q+ SL AE R + +E+V+++ ++E+ + E +
Sbjct: 1985 EAEERVQK-------------SLAAEEEAARQRKA---ALEEVERLKAKVEEARRLRERA 2028
Query: 494 VFEEALMSPDTRYRCHRKDSLPDADLASCGSLSQSSASFFTPRSTRNDELLSDLTRTPPP 553
E A + ++ L + A ++ Q ++ + ++ + D R
Sbjct: 2029 EQESARQLQLAQEAAQKR--LQAEEKAHAFAVQQKEQEL--QQTLQQEQSVLDQLR---G 2081
Query: 554 PSSTFPKASSESSYLSILPKTPEGISEEQ--RSQELAAMEETRIVILNNLEELKQKIKDI 611
+ +A+ E+ + + S Q ++ L E + + +K++
Sbjct: 2082 EAEAARRAAEEAEEARVQAEREAAQSRRQVEEAERLKQSAEEQAQARAQAQAAAEKLRKE 2141
Query: 612 NDQMDESFRELDMECALLDGEQKSETTELMKEKEILDHLNRKIAELEKNIVGEKTKDADL 671
+Q E+ R E A L +Q ++ E+ K K+ + R+ A++E+ + +
Sbjct: 2142 AEQ--EAARRAQAEQAALRQKQAAD-AEMEKHKKFAEQTLRQKAQVEQELTTLR------ 2192
Query: 672 LDVESKHFEDLEFQQLEHESRLDEEKENLTQQLLREVAEYQRNIVSRKEKISALKKQANH 731
L+ ++ +H+ L +E+ Q+L E E R +E++ +++ Q
Sbjct: 2193 ----------LQLEETDHQKNLLDEE---LQRLKAEATEAARQRSQVEEELFSVRVQMEE 2239
Query: 732 IVQ-QAQREQDH---FVKEKNNLIMMLQREKENLCNLEKKYSSLSGGKGFPVNPNTLKEG 787
+ + +A+ E ++ +++K+N LQ E E + + ++ + LS L E
Sbjct: 2240 LSKLKARIEAENRALILRDKDNTQRFLQEEAEKMKQVAEEAARLSVAAQEAARLRQLAEE 2299
Query: 788 YIS---------VNEINEPCGNSTNLSPSTQFPADADAVATEPATAVLASQPQSKEHF-- 836
++ + E + +T L + +A E A + + Q +
Sbjct: 2300 DLAQQRALAEKMLKEKMQAVQEATRLKAEAELLQQQKELAQEQARRLQEDKEQMAQQLAE 2359
Query: 837 ------RSLEERKKQHKEGLYLSDTLPRKKTTSSISPHFSSATMGRSITPKAHLPLGQSN 890
R+LE +++ E ++ L K + +S + A K +G+
Sbjct: 2360 ETQGFQRTLEAERQRQLEMSAEAERL--KLRVAEMSRAQARAEEDAQRFRKQAEEIGEKL 2417
Query: 891 SCGSVLPPSLAAMAKDSESRRMLRGYNHQQMSEGHRQKSEFYNRTASESNVY------LN 944
+ + + E +R ++ +++ E + + E+ + +
Sbjct: 2418 HRTELATQEKVTLVQTLEIQRQQSDHDAERLREAIAELEREKEKLQQEAKLLQLKSEEMQ 2477
Query: 945 SFHYPDHSYKDQAFDTLSLDSSDSM----------ETSISACSPDNISSASTSNIARIEE 994
+ + QA L DS+ + + D ++ A EE
Sbjct: 2478 TVQQEQLLQETQALQQSFLSEKDSLLQRERFIEQEKAKLEQLFQDEVAKAQQLR----EE 2533
Query: 995 MERLLKQAHAEKTRLLESREREMEAKKRALEEEKRRREILEKRLQEETSQRQKLIEKEVK 1054
+R +Q E+ RL+ S E + A E +R++E L++ Q+ Q + L E+ +
Sbjct: 2534 QQRQQQQMEQERQRLVASMEEARRRQHEAEEGVRRKQEELQQLEQQRRQQEELLAEENQR 2593
Query: 1055 IRER 1058
+RE+
Sbjct: 2594 LREQ 2597
Score = 41.6 bits (96), Expect = 0.005
Identities = 130/723 (17%), Positives = 291/723 (40%), Gaps = 89/723 (12%)
Query: 392 EADLESLRQASGTPQPALRERKSSISSISGRDDLMDYHRRQRE----ERLREQEMERLER 447
EA+L+S R AS + A ER ++ + RR ++ ER RE+ LER
Sbjct: 1575 EAELQSKR-ASFAEKTAQLERSLQEEHVAVAQLREEAERRAQQQAEAERAREEAERELER 1633
Query: 448 QRLETI----LSLCAEYTKPDSRLSTGTTVEDVQKINKELEKLQLSDEESVFEEALMSPD 503
+L+ L L AE L+ + ++ +E + ++E++V + L +
Sbjct: 1634 WQLKANEALRLRLQAEEVAQQKSLAQAEAEKQKEEAEREARRRGKAEEQAVRQRELAEQE 1693
Query: 504 TRYRCHRKDSLPDADLASCGSLSQSSASFFTPRSTRNDELLSD-LTRTPPPPSSTFPKAS 562
+ + LA+ L + A T + + +LL + L R ++ K
Sbjct: 1694 LEKQRQLAEGTAQQRLAAEQELIRLRAE--TEQGEQQRQLLEEELARLQREAAAATQKRQ 1751
Query: 563 SESSYLSILPKTPEGISEEQRSQELAAMEETRIVILNNLEELKQKIKDINDQMDESFREL 622
+ L+ + E + + E EE+R + E+ KQ+++ + FREL
Sbjct: 1752 ELEAELAKVRAEMEVLLASKARAE----EESR----STSEKSKQRLEAEAGR----FREL 1799
Query: 623 DMECALLDGEQKSETTELMKEKEILDH-LNRKIAELEKNIVGEKTKDADLLDVESKHFED 681
E A L ++ E +++++ + R+ AE E+ + + + ++++
Sbjct: 1800 AEEAARL----RALAEEAKRQRQLAEEDAARQRAEAERVLAEKLAAIGEATRLKTEAEIA 1855
Query: 682 LEFQQLEHES--RLDEEKENLTQQLLREVAEYQRNIVSRKEKISALKKQANHIVQQAQRE 739
L+ ++ E+E RL E++ ++L + A+++ +I +E+++ L+K ++ +++ +
Sbjct: 1856 LKEKEAENERLRRLAEDEAFQRRRLEEQAAQHKADI---EERLAQLRKASDSELERQKGL 1912
Query: 740 QDHFVKEKNNLIMMLQREKENLCNLEKKYSSLSGGKGFPVNPNTLKEGYISVNEINEPCG 799
+ ++++ + +E + L+ + + GK E + + I
Sbjct: 1913 VEDTLRQRRQV-------EEEILALKASFEKAAAGKA---------ELELELGRIRSNAE 1956
Query: 800 NSTNLSPSTQFPADADA-VATEPATAVLASQPQSKEHFRSLEERKKQHKEGLYLSDTLPR 858
++ + A +A E ++ + ++ + EE +Q K L + L
Sbjct: 1957 DTLRSKEQAELEAARQRQLAAEEERRRREAEERVQKSLAAEEEAARQRKAALEEVERLKA 2016
Query: 859 KKTTSSISPHFSSATMGRSITPKAHLPLGQSNSCGSVLPPSLAAMAKDSESRRMLRGYNH 918
K + + R + + Q + A K+ E ++ L+
Sbjct: 2017 KVEEARRLRERAEQESARQL--QLAQEAAQKRLQAEEKAHAFAVQQKEQELQQTLQ--QE 2072
Query: 919 QQMSEGHRQKSEFYNRTASESNVYLNSFHYPDHSYKDQAFDTLSLDSSDSMETSISACSP 978
Q + + R ++E R A E+ + ++ A ++ ++ ++ S +
Sbjct: 2073 QSVLDQLRGEAEAARRAAEEAE------EARVQAEREAAQSRRQVEEAERLKQSAEEQAQ 2126
Query: 979 DNISSASTSNIARIEEMERLLKQAHAEKTRLLESR----------EREMEAKKRALEEEK 1028
+ + + E+L K+A E R ++ + EME K+ E+
Sbjct: 2127 ARAQAQAAA--------EKLRKEAEQEAARRAQAEQAALRQKQAADAEMEKHKKFAEQTL 2178
Query: 1029 RRREILEKRLQ------EETSQRQKLIEKEVKIRERQRAQARPLTRY-LPVRKEDFDLRS 1081
R++ +E+ L EET ++ L+++E+ +R +A+A R V +E F +R
Sbjct: 2179 RQKAQVEQELTTLRLQLEETDHQKNLLDEEL---QRLKAEATEAARQRSQVEEELFSVRV 2235
Query: 1082 HVE 1084
+E
Sbjct: 2236 QME 2238
Score = 34.3 bits (77), Expect = 0.74
Identities = 33/108 (30%), Positives = 51/108 (47%), Gaps = 17/108 (15%)
Query: 993 EEMERLLKQAHAEKTRLLESREREMEAKKRALEEEKRR--------REILE-----KRLQ 1039
+E+E L + AE LL S+ R E + E+ K+R RE+ E + L
Sbjct: 1751 QELEAELAKVRAEMEVLLASKARAEEESRSTSEKSKQRLEAEAGRFRELAEEAARLRALA 1810
Query: 1040 EETSQRQKLIEKEVKIRERQRAQA-RPLTRYLPVRKEDFDLRSHVETA 1086
EE ++++L E++ RQRA+A R L L E L++ E A
Sbjct: 1811 EEAKRQRQLAEEDA---ARQRAEAERVLAEKLAAIGEATRLKTEAEIA 1855
>gi|41322910 plectin 1 isoform 7 [Homo sapiens]
Length = 4515
Score = 54.3 bits (129), Expect = 7e-07
Identities = 145/734 (19%), Positives = 282/734 (38%), Gaps = 81/734 (11%)
Query: 389 EFDEADLESLRQ-ASGTPQPALRERKSSISSISGRDDLMDYHRRQREERLREQEMERLER 447
E E +LE RQ A GT Q L + I + + + +++ +L E+E+ RL+R
Sbjct: 1656 ELAEQELEKQRQLAEGTAQQRLAAEQELIRLRA------ETEQGEQQRQLLEEELARLQR 1709
Query: 448 Q-------RLETILSLCAEYTKPDSRLSTGTTVEDVQKINKELEKLQLSDEESVFEEALM 500
+ R E L + + L++ E+ + E K +L E F E L
Sbjct: 1710 EAAAATQKRQELEAELAKVRAEMEVLLASKARAEEESRSTSEKSKQRLEAEAGRFRE-LA 1768
Query: 501 SPDTRYRCHRKDSLPDADLASCGSLSQSSASFFTPRSTRNDEL--LSDLTRTPPPPSSTF 558
R R +++ LA + Q + + ++L + + TR
Sbjct: 1769 EEAARLRALAEEAKRQRQLAEEDAARQRAEA----ERVLAEKLAAIGEATRLKTEAEIAL 1824
Query: 559 PKASSESSYLSILPKTPEGISEEQRSQELAAMEETRIVILNNLEELKQKIKDINDQMDES 618
+ +E+ L L + + + +R +E AA + ++EE +++ +D E
Sbjct: 1825 KEKEAENERLRRLAE--DEAFQRRRLEEQAAQHKA------DIEERLAQLRKASDSELER 1876
Query: 619 FRELDMECALLDGEQKSETTELMKEKEILDHLNRKIAELEKNIVGEKTKDADLL-DVESK 677
+ L +E L Q E E++ K + AELE + ++ D L E
Sbjct: 1877 QKGL-VEDTLRQRRQVEE--EILALKASFEKAAAGKAELELELGRIRSNAEDTLRSKEQA 1933
Query: 678 HFEDLEFQQL--EHESRLDEEKENLTQQLL--REVAEYQRNIVSRKEKISALKKQANHIV 733
E +QL E E R E +E + + L E A ++ + E++ A ++A +
Sbjct: 1934 ELEAARQRQLAAEEERRRREAEERVQKSLAAEEEAARQRKAALEEVERLKAKVEEARRLR 1993
Query: 734 QQAQREQDHFVK-------------EKNNLIMMLQREKENLCNLEKKYSSLSGGKGFPVN 780
++A++E ++ EK + + Q+E+E L+++ S L +G
Sbjct: 1994 ERAEQESARQLQLAQEAAQKRLQAEEKAHAFAVQQKEQELQQTLQQEQSVLDQLRGEAEA 2053
Query: 781 PNTLKEGY--ISVNEINEPCGNSTNLSPSTQFPADADAVATEPATAVLASQPQSKEHFRS 838
E V E + + + + A+ A A A A++ KE +
Sbjct: 2054 ARRAAEEAEEARVQAEREAAQSRRQVEEAERLKQSAEEQAQARAQAQAAAEKLRKEAEQE 2113
Query: 839 LEERKKQHKEGL---YLSDTLPRKKTTSSISPHFSSATMGRSITPKAHLPLGQSNSCGSV 895
R + + L +D K + A + + +T L L +++ ++
Sbjct: 2114 AARRAQAEQAALRQKQAADAEMEKHKKFAEQTLRQKAQVEQELTT-LRLQLEETDHQKNL 2172
Query: 896 LPPSLAAMAKDSESRRMLRGYNHQQMSEGHRQKSEFYN---RTASESNVYLNSFHYPDHS 952
L L + ++ R +++ Q E R +E+ +
Sbjct: 2173 LDEELQRLKAEATEAARQRSQVEEELFSVRVQMEELSKLKARIEAENRALILRDKDNTQR 2232
Query: 953 YKDQAFDTLSLDSSDSMETSISACSPDNISSASTSNIARIEEM-ERLLK---QAHAEKTR 1008
+ + + + + ++ S++A + + ++A+ + E++LK QA E TR
Sbjct: 2233 FLQEEAEKMKQVAEEAARLSVAAQEAARLRQLAEEDLAQQRALAEKMLKEKMQAVQEATR 2292
Query: 1009 LLESREREMEAKKRALEEEKRRREILEK---RLQEETSQRQKLIEKE------------- 1052
L E + K+ A E+ +R +E E+ +L EET Q+ +E E
Sbjct: 2293 LKAEAELLQQQKELAQEQARRLQEDKEQMAQQLAEETQGFQRTLEAERQRQLEMSAEAER 2352
Query: 1053 --VKIRERQRAQAR 1064
+++ E RAQAR
Sbjct: 2353 LKLRVAEMSRAQAR 2366
Score = 48.5 bits (114), Expect = 4e-05
Identities = 50/211 (23%), Positives = 100/211 (47%), Gaps = 28/211 (13%)
Query: 573 KTPEGISEEQRSQELAAMEETRIVILNNLEELKQKIKDINDQMDESFRELDMECALLDGE 632
K E I E+ ELA E ++ ++ LE +Q+ +++ E+ EL+ E L E
Sbjct: 2376 KQAEEIGEKLHRTELATQE--KVTLVQTLEIQRQQSDHDAERLREAIAELEREKEKLQQE 2433
Query: 633 QK-----SETTELMKEKEILDH--------LNRK--IAELEKNIVGEKTKDADLLDVESK 677
K SE + ++++++L L+ K + + E+ I EK K L E
Sbjct: 2434 AKLLQLKSEEMQTVQQEQLLQETQALQQSFLSEKDSLLQRERFIEQEKAKLEQLFQDEVA 2493
Query: 678 HFEDLEFQQLEHESRLDEEKENLTQQLLREVAEYQRNIVSRKEKISALKKQANHIVQQAQ 737
+ L +Q + ++++E+ Q+L+ + E +R +E + +++ + QQ +
Sbjct: 2494 KAQQLREEQQRQQQQMEQER----QRLVASMEEARRRQHEAEEGVRRKQEELQQLEQQ-R 2548
Query: 738 REQDHFVKEKNNLIMMLQREKENLCNLEKKY 768
R+Q+ + E+N QR +E L LE+++
Sbjct: 2549 RQQEELLAEEN------QRLREQLQLLEEQH 2573
Score = 45.1 bits (105), Expect = 4e-04
Identities = 176/972 (18%), Positives = 367/972 (37%), Gaps = 169/972 (17%)
Query: 200 SMPSSPKQARKMSIQDSLALQPKLTRHKELASENINLRTRKYSSSSLSHMGAYSRSLPRL 259
+MP + QA + ++ AL ++ RH E E ++++ ++ + Y L
Sbjct: 1203 AMPLADSQAVREQLRQEQALLEEIERHGEKVEE-----CQRFAKQYINAIKDYELQLV-T 1256
Query: 260 YRATENQLTPLSLPPRNSLGNSKRTKLGEKDLPHSVID-NDNYLNFSSLSSGALPY---- 314
Y+A QL P++ P + + + G + + +D +Y ++L+S + +
Sbjct: 1257 YKA---QLEPVASPAK-----KPKVQSGSESVIQEYVDLRTHYSELTTLTSQYIKFISET 1308
Query: 315 -------KTSASEGNPYVSSTLSVPASPRVARKMLLASTSSCASDDFDQASYVGTNPSHS 367
+ A + L+ + ++ L + + + +A +
Sbjct: 1309 LRRMEEEERLAEQQRAEERERLAEVEAALEKQRQLAEAHAQAKAQAEREAKELQQRMQEE 1368
Query: 368 LLAGESDRVFATRRNFSCGSV-----EFDEADLES-LRQASGTPQPALR----------E 411
++ E V A ++ S + EA++++ RQA + LR +
Sbjct: 1369 VVRREEAAVDAQQQKRSIQEELQQLRQSSEAEIQAKARQAEAAERSRLRIEEEIRVVRLQ 1428
Query: 412 RKSSISSISGRDDLMDYHRRQREE-----RLREQEMERLERQ-RLETILSLCAEYTKPDS 465
+++ G + + R + EE R ++E ERL RQ + E+ AE
Sbjct: 1429 LEATERQRGGAEGELQALRARAEEAEAQKRQAQEEAERLRRQVQDESQRKRQAEVELASR 1488
Query: 466 RLSTGTTVEDVQKINKELEKLQLSDEESVFEEALMSPDTRYRCHRKDSLPDADLASCGSL 525
+ + Q+ + LE+L+L EE+ E L + + +L A ++ L
Sbjct: 1489 VKAEAEAAREKQRALQALEELRLQAEEA--ERRLRQAEVERARQVQVALETAQRSAEAEL 1546
Query: 526 SQSSASFFTPRSTRNDELLSDLTRTPPPPSSTFPKASSESSYLSILPKTPEGISEEQRSQ 585
ASF E + L R S + ++++ E E+R+Q
Sbjct: 1547 QSKRASF--------AEKTAQLER------------SLQEEHVAVAQLREEA---ERRAQ 1583
Query: 586 ELAAMEETRIVILNNLEELKQKIKDINDQMDESFRELDMECALLDGEQKSETTELMKEKE 645
+ A E R EE +++++ + +E+ R L ++ + ++ E K+KE
Sbjct: 1584 QQAEAERAR-------EEAERELERWQLKANEALR-LRLQAEEVAQQKSLAQAEAEKQKE 1635
Query: 646 ILDHLNRKIAELEKNIVGEKTKDADLLDVESKHFEDLEFQQLEHESRLDEEKENLTQQLL 705
+ R+ + E+ V ++ L+ + + E + RL E+E + +
Sbjct: 1636 EAEREARRRGKAEEQAVRQRELAEQELEKQRQLAEGTA------QQRLAAEQELIRLRAE 1689
Query: 706 REVAEYQRNIVSRKEKISALKKQANHIVQQAQREQDHFVKEKNNLIMML----QREKENL 761
E E QR ++ +E+++ L+++A Q+ Q + K + + ++L + E+E+
Sbjct: 1690 TEQGEQQRQLL--EEELARLQREAAAATQKRQELEAELAKVRAEMEVLLASKARAEEESR 1747
Query: 762 CNLEKKYSSLSGGKGFPVNPNTLKEGYISVNEINEPCGNSTNLS--PSTQFPADADAVAT 819
EK L G L E + + E L+ + + A+A+ V
Sbjct: 1748 STSEKSKQRLEAEAG---RFRELAEEAARLRALAEEAKRQRQLAEEDAARQRAEAERVLA 1804
Query: 820 EPATAV-----------LASQPQSKEH-------------FRSLEERKKQHKEGL----- 850
E A+ +A + + E+ R LEE+ QHK +
Sbjct: 1805 EKLAAIGEATRLKTEAEIALKEKEAENERLRRLAEDEAFQRRRLEEQAAQHKADIEERLA 1864
Query: 851 ---------------YLSDTLPRKKTTS----SISPHFSSATMGRSITPKAHLPLGQSNS 891
+ DTL +++ ++ F A G++ + L LG+ S
Sbjct: 1865 QLRKASDSELERQKGLVEDTLRQRRQVEEEILALKASFEKAAAGKA---ELELELGRIRS 1921
Query: 892 CG---------SVLPPSLAAMAKDSESRRMLRGYNHQQMSEGHRQKSEFYNRTASESNVY 942
+ L + E RR Q S +++ + A E
Sbjct: 1922 NAEDTLRSKEQAELEAARQRQLAAEEERRRREAEERVQKSLAAEEEAARQRKAALEEVER 1981
Query: 943 LNSFHYPDHSYKDQAFDTLSLDSSDSMETSISACSPDNISSASTSNIARIEEMERLLKQA 1002
L + +++A +S+ ++ + A + + + ++ +++ E+ L+Q
Sbjct: 1982 LKAKVEEARRLRERA----EQESARQLQLAQEA-AQKRLQAEEKAHAFAVQQKEQELQQT 2036
Query: 1003 HAEKTRLLESREREMEAKKRALEEEKR-----RREILEKRLQEETSQRQK-LIEKEVKIR 1056
++ +L+ E EA +RA EE + RE + R Q E ++R K E++ + R
Sbjct: 2037 LQQEQSVLDQLRGEAEAARRAAEEAEEARVQAEREAAQSRRQVEEAERLKQSAEEQAQAR 2096
Query: 1057 ERQRAQARPLTR 1068
+ +A A L +
Sbjct: 2097 AQAQAAAEKLRK 2108
Score = 45.1 bits (105), Expect = 4e-04
Identities = 121/724 (16%), Positives = 272/724 (37%), Gaps = 90/724 (12%)
Query: 374 DRVFATRRNFSCGSVEFDEADLESLRQASGTPQPALRERKSSISSISGRDDLMDYHRRQR 433
+ + A + +F + E +LE R S + ++ + + R + RR+R
Sbjct: 1893 EEILALKASFEKAAAGKAELELELGRIRSNAEDTLRSKEQAELEAARQRQLAAEEERRRR 1952
Query: 434 EERLREQEMERLERQRLETILSLCAEYTKPDSRLSTGTTVEDVQKINKELEKLQLSDEES 493
E R Q+ SL AE R + +E+V+++ ++E+ + E +
Sbjct: 1953 EAEERVQK-------------SLAAEEEAARQRKA---ALEEVERLKAKVEEARRLRERA 1996
Query: 494 VFEEALMSPDTRYRCHRKDSLPDADLASCGSLSQSSASFFTPRSTRNDELLSDLTRTPPP 553
E A + ++ L + A ++ Q ++ + ++ + D R
Sbjct: 1997 EQESARQLQLAQEAAQKR--LQAEEKAHAFAVQQKEQEL--QQTLQQEQSVLDQLR---G 2049
Query: 554 PSSTFPKASSESSYLSILPKTPEGISEEQ--RSQELAAMEETRIVILNNLEELKQKIKDI 611
+ +A+ E+ + + S Q ++ L E + + +K++
Sbjct: 2050 EAEAARRAAEEAEEARVQAEREAAQSRRQVEEAERLKQSAEEQAQARAQAQAAAEKLRKE 2109
Query: 612 NDQMDESFRELDMECALLDGEQKSETTELMKEKEILDHLNRKIAELEKNIVGEKTKDADL 671
+Q E+ R E A L +Q ++ E+ K K+ + R+ A++E+ + +
Sbjct: 2110 AEQ--EAARRAQAEQAALRQKQAAD-AEMEKHKKFAEQTLRQKAQVEQELTTLR------ 2160
Query: 672 LDVESKHFEDLEFQQLEHESRLDEEKENLTQQLLREVAEYQRNIVSRKEKISALKKQANH 731
L+ ++ +H+ L +E+ Q+L E E R +E++ +++ Q
Sbjct: 2161 ----------LQLEETDHQKNLLDEE---LQRLKAEATEAARQRSQVEEELFSVRVQMEE 2207
Query: 732 IVQ-QAQREQDH---FVKEKNNLIMMLQREKENLCNLEKKYSSLSGGKGFPVNPNTLKEG 787
+ + +A+ E ++ +++K+N LQ E E + + ++ + LS L E
Sbjct: 2208 LSKLKARIEAENRALILRDKDNTQRFLQEEAEKMKQVAEEAARLSVAAQEAARLRQLAEE 2267
Query: 788 YIS---------VNEINEPCGNSTNLSPSTQFPADADAVATEPATAVLASQPQSKEHF-- 836
++ + E + +T L + +A E A + + Q +
Sbjct: 2268 DLAQQRALAEKMLKEKMQAVQEATRLKAEAELLQQQKELAQEQARRLQEDKEQMAQQLAE 2327
Query: 837 ------RSLEERKKQHKEGLYLSDTLPRKKTTSSISPHFSSATMGRSITPKAHLPLGQSN 890
R+LE +++ E ++ L K + +S + A K +G+
Sbjct: 2328 ETQGFQRTLEAERQRQLEMSAEAERL--KLRVAEMSRAQARAEEDAQRFRKQAEEIGEKL 2385
Query: 891 SCGSVLPPSLAAMAKDSESRRMLRGYNHQQMSEGHRQKSEFYNRTASESNVY------LN 944
+ + + E +R ++ +++ E + + E+ + +
Sbjct: 2386 HRTELATQEKVTLVQTLEIQRQQSDHDAERLREAIAELEREKEKLQQEAKLLQLKSEEMQ 2445
Query: 945 SFHYPDHSYKDQAFDTLSLDSSDSM----------ETSISACSPDNISSASTSNIARIEE 994
+ + QA L DS+ + + D ++ A EE
Sbjct: 2446 TVQQEQLLQETQALQQSFLSEKDSLLQRERFIEQEKAKLEQLFQDEVAKAQQLR----EE 2501
Query: 995 MERLLKQAHAEKTRLLESREREMEAKKRALEEEKRRREILEKRLQEETSQRQKLIEKEVK 1054
+R +Q E+ RL+ S E + A E +R++E L++ Q+ Q + L E+ +
Sbjct: 2502 QQRQQQQMEQERQRLVASMEEARRRQHEAEEGVRRKQEELQQLEQQRRQQEELLAEENQR 2561
Query: 1055 IRER 1058
+RE+
Sbjct: 2562 LREQ 2565
Score = 41.6 bits (96), Expect = 0.005
Identities = 130/723 (17%), Positives = 291/723 (40%), Gaps = 89/723 (12%)
Query: 392 EADLESLRQASGTPQPALRERKSSISSISGRDDLMDYHRRQRE----ERLREQEMERLER 447
EA+L+S R AS + A ER ++ + RR ++ ER RE+ LER
Sbjct: 1543 EAELQSKR-ASFAEKTAQLERSLQEEHVAVAQLREEAERRAQQQAEAERAREEAERELER 1601
Query: 448 QRLETI----LSLCAEYTKPDSRLSTGTTVEDVQKINKELEKLQLSDEESVFEEALMSPD 503
+L+ L L AE L+ + ++ +E + ++E++V + L +
Sbjct: 1602 WQLKANEALRLRLQAEEVAQQKSLAQAEAEKQKEEAEREARRRGKAEEQAVRQRELAEQE 1661
Query: 504 TRYRCHRKDSLPDADLASCGSLSQSSASFFTPRSTRNDELLSD-LTRTPPPPSSTFPKAS 562
+ + LA+ L + A T + + +LL + L R ++ K
Sbjct: 1662 LEKQRQLAEGTAQQRLAAEQELIRLRAE--TEQGEQQRQLLEEELARLQREAAAATQKRQ 1719
Query: 563 SESSYLSILPKTPEGISEEQRSQELAAMEETRIVILNNLEELKQKIKDINDQMDESFREL 622
+ L+ + E + + E EE+R + E+ KQ+++ + FREL
Sbjct: 1720 ELEAELAKVRAEMEVLLASKARAE----EESR----STSEKSKQRLEAEAGR----FREL 1767
Query: 623 DMECALLDGEQKSETTELMKEKEILDH-LNRKIAELEKNIVGEKTKDADLLDVESKHFED 681
E A L ++ E +++++ + R+ AE E+ + + + ++++
Sbjct: 1768 AEEAARL----RALAEEAKRQRQLAEEDAARQRAEAERVLAEKLAAIGEATRLKTEAEIA 1823
Query: 682 LEFQQLEHES--RLDEEKENLTQQLLREVAEYQRNIVSRKEKISALKKQANHIVQQAQRE 739
L+ ++ E+E RL E++ ++L + A+++ +I +E+++ L+K ++ +++ +
Sbjct: 1824 LKEKEAENERLRRLAEDEAFQRRRLEEQAAQHKADI---EERLAQLRKASDSELERQKGL 1880
Query: 740 QDHFVKEKNNLIMMLQREKENLCNLEKKYSSLSGGKGFPVNPNTLKEGYISVNEINEPCG 799
+ ++++ + +E + L+ + + GK E + + I
Sbjct: 1881 VEDTLRQRRQV-------EEEILALKASFEKAAAGKA---------ELELELGRIRSNAE 1924
Query: 800 NSTNLSPSTQFPADADA-VATEPATAVLASQPQSKEHFRSLEERKKQHKEGLYLSDTLPR 858
++ + A +A E ++ + ++ + EE +Q K L + L
Sbjct: 1925 DTLRSKEQAELEAARQRQLAAEEERRRREAEERVQKSLAAEEEAARQRKAALEEVERLKA 1984
Query: 859 KKTTSSISPHFSSATMGRSITPKAHLPLGQSNSCGSVLPPSLAAMAKDSESRRMLRGYNH 918
K + + R + + Q + A K+ E ++ L+
Sbjct: 1985 KVEEARRLRERAEQESARQL--QLAQEAAQKRLQAEEKAHAFAVQQKEQELQQTLQ--QE 2040
Query: 919 QQMSEGHRQKSEFYNRTASESNVYLNSFHYPDHSYKDQAFDTLSLDSSDSMETSISACSP 978
Q + + R ++E R A E+ + ++ A ++ ++ ++ S +
Sbjct: 2041 QSVLDQLRGEAEAARRAAEEAE------EARVQAEREAAQSRRQVEEAERLKQSAEEQAQ 2094
Query: 979 DNISSASTSNIARIEEMERLLKQAHAEKTRLLESR----------EREMEAKKRALEEEK 1028
+ + + E+L K+A E R ++ + EME K+ E+
Sbjct: 2095 ARAQAQAAA--------EKLRKEAEQEAARRAQAEQAALRQKQAADAEMEKHKKFAEQTL 2146
Query: 1029 RRREILEKRLQ------EETSQRQKLIEKEVKIRERQRAQARPLTRY-LPVRKEDFDLRS 1081
R++ +E+ L EET ++ L+++E+ +R +A+A R V +E F +R
Sbjct: 2147 RQKAQVEQELTTLRLQLEETDHQKNLLDEEL---QRLKAEATEAARQRSQVEEELFSVRV 2203
Query: 1082 HVE 1084
+E
Sbjct: 2204 QME 2206
Score = 34.3 bits (77), Expect = 0.74
Identities = 33/108 (30%), Positives = 51/108 (47%), Gaps = 17/108 (15%)
Query: 993 EEMERLLKQAHAEKTRLLESREREMEAKKRALEEEKRR--------REILE-----KRLQ 1039
+E+E L + AE LL S+ R E + E+ K+R RE+ E + L
Sbjct: 1719 QELEAELAKVRAEMEVLLASKARAEEESRSTSEKSKQRLEAEAGRFRELAEEAARLRALA 1778
Query: 1040 EETSQRQKLIEKEVKIRERQRAQA-RPLTRYLPVRKEDFDLRSHVETA 1086
EE ++++L E++ RQRA+A R L L E L++ E A
Sbjct: 1779 EEAKRQRQLAEEDA---ARQRAEAERVLAEKLAAIGEATRLKTEAEIA 1823
>gi|41322916 plectin 1 isoform 6 [Homo sapiens]
Length = 4684
Score = 54.3 bits (129), Expect = 7e-07
Identities = 145/734 (19%), Positives = 282/734 (38%), Gaps = 81/734 (11%)
Query: 389 EFDEADLESLRQ-ASGTPQPALRERKSSISSISGRDDLMDYHRRQREERLREQEMERLER 447
E E +LE RQ A GT Q L + I + + + +++ +L E+E+ RL+R
Sbjct: 1825 ELAEQELEKQRQLAEGTAQQRLAAEQELIRLRA------ETEQGEQQRQLLEEELARLQR 1878
Query: 448 Q-------RLETILSLCAEYTKPDSRLSTGTTVEDVQKINKELEKLQLSDEESVFEEALM 500
+ R E L + + L++ E+ + E K +L E F E L
Sbjct: 1879 EAAAATQKRQELEAELAKVRAEMEVLLASKARAEEESRSTSEKSKQRLEAEAGRFRE-LA 1937
Query: 501 SPDTRYRCHRKDSLPDADLASCGSLSQSSASFFTPRSTRNDEL--LSDLTRTPPPPSSTF 558
R R +++ LA + Q + + ++L + + TR
Sbjct: 1938 EEAARLRALAEEAKRQRQLAEEDAARQRAEA----ERVLAEKLAAIGEATRLKTEAEIAL 1993
Query: 559 PKASSESSYLSILPKTPEGISEEQRSQELAAMEETRIVILNNLEELKQKIKDINDQMDES 618
+ +E+ L L + + + +R +E AA + ++EE +++ +D E
Sbjct: 1994 KEKEAENERLRRLAE--DEAFQRRRLEEQAAQHKA------DIEERLAQLRKASDSELER 2045
Query: 619 FRELDMECALLDGEQKSETTELMKEKEILDHLNRKIAELEKNIVGEKTKDADLL-DVESK 677
+ L +E L Q E E++ K + AELE + ++ D L E
Sbjct: 2046 QKGL-VEDTLRQRRQVEE--EILALKASFEKAAAGKAELELELGRIRSNAEDTLRSKEQA 2102
Query: 678 HFEDLEFQQL--EHESRLDEEKENLTQQLL--REVAEYQRNIVSRKEKISALKKQANHIV 733
E +QL E E R E +E + + L E A ++ + E++ A ++A +
Sbjct: 2103 ELEAARQRQLAAEEERRRREAEERVQKSLAAEEEAARQRKAALEEVERLKAKVEEARRLR 2162
Query: 734 QQAQREQDHFVK-------------EKNNLIMMLQREKENLCNLEKKYSSLSGGKGFPVN 780
++A++E ++ EK + + Q+E+E L+++ S L +G
Sbjct: 2163 ERAEQESARQLQLAQEAAQKRLQAEEKAHAFAVQQKEQELQQTLQQEQSVLDQLRGEAEA 2222
Query: 781 PNTLKEGY--ISVNEINEPCGNSTNLSPSTQFPADADAVATEPATAVLASQPQSKEHFRS 838
E V E + + + + A+ A A A A++ KE +
Sbjct: 2223 ARRAAEEAEEARVQAEREAAQSRRQVEEAERLKQSAEEQAQARAQAQAAAEKLRKEAEQE 2282
Query: 839 LEERKKQHKEGL---YLSDTLPRKKTTSSISPHFSSATMGRSITPKAHLPLGQSNSCGSV 895
R + + L +D K + A + + +T L L +++ ++
Sbjct: 2283 AARRAQAEQAALRQKQAADAEMEKHKKFAEQTLRQKAQVEQELTT-LRLQLEETDHQKNL 2341
Query: 896 LPPSLAAMAKDSESRRMLRGYNHQQMSEGHRQKSEFYN---RTASESNVYLNSFHYPDHS 952
L L + ++ R +++ Q E R +E+ +
Sbjct: 2342 LDEELQRLKAEATEAARQRSQVEEELFSVRVQMEELSKLKARIEAENRALILRDKDNTQR 2401
Query: 953 YKDQAFDTLSLDSSDSMETSISACSPDNISSASTSNIARIEEM-ERLLK---QAHAEKTR 1008
+ + + + + ++ S++A + + ++A+ + E++LK QA E TR
Sbjct: 2402 FLQEEAEKMKQVAEEAARLSVAAQEAARLRQLAEEDLAQQRALAEKMLKEKMQAVQEATR 2461
Query: 1009 LLESREREMEAKKRALEEEKRRREILEK---RLQEETSQRQKLIEKE------------- 1052
L E + K+ A E+ +R +E E+ +L EET Q+ +E E
Sbjct: 2462 LKAEAELLQQQKELAQEQARRLQEDKEQMAQQLAEETQGFQRTLEAERQRQLEMSAEAER 2521
Query: 1053 --VKIRERQRAQAR 1064
+++ E RAQAR
Sbjct: 2522 LKLRVAEMSRAQAR 2535
Score = 48.5 bits (114), Expect = 4e-05
Identities = 50/211 (23%), Positives = 100/211 (47%), Gaps = 28/211 (13%)
Query: 573 KTPEGISEEQRSQELAAMEETRIVILNNLEELKQKIKDINDQMDESFRELDMECALLDGE 632
K E I E+ ELA E ++ ++ LE +Q+ +++ E+ EL+ E L E
Sbjct: 2545 KQAEEIGEKLHRTELATQE--KVTLVQTLEIQRQQSDHDAERLREAIAELEREKEKLQQE 2602
Query: 633 QK-----SETTELMKEKEILDH--------LNRK--IAELEKNIVGEKTKDADLLDVESK 677
K SE + ++++++L L+ K + + E+ I EK K L E
Sbjct: 2603 AKLLQLKSEEMQTVQQEQLLQETQALQQSFLSEKDSLLQRERFIEQEKAKLEQLFQDEVA 2662
Query: 678 HFEDLEFQQLEHESRLDEEKENLTQQLLREVAEYQRNIVSRKEKISALKKQANHIVQQAQ 737
+ L +Q + ++++E+ Q+L+ + E +R +E + +++ + QQ +
Sbjct: 2663 KAQQLREEQQRQQQQMEQER----QRLVASMEEARRRQHEAEEGVRRKQEELQQLEQQ-R 2717
Query: 738 REQDHFVKEKNNLIMMLQREKENLCNLEKKY 768
R+Q+ + E+N QR +E L LE+++
Sbjct: 2718 RQQEELLAEEN------QRLREQLQLLEEQH 2742
Score = 45.1 bits (105), Expect = 4e-04
Identities = 176/972 (18%), Positives = 367/972 (37%), Gaps = 169/972 (17%)
Query: 200 SMPSSPKQARKMSIQDSLALQPKLTRHKELASENINLRTRKYSSSSLSHMGAYSRSLPRL 259
+MP + QA + ++ AL ++ RH E E ++++ ++ + Y L
Sbjct: 1372 AMPLADSQAVREQLRQEQALLEEIERHGEKVEE-----CQRFAKQYINAIKDYELQLV-T 1425
Query: 260 YRATENQLTPLSLPPRNSLGNSKRTKLGEKDLPHSVID-NDNYLNFSSLSSGALPY---- 314
Y+A QL P++ P + + + G + + +D +Y ++L+S + +
Sbjct: 1426 YKA---QLEPVASPAK-----KPKVQSGSESVIQEYVDLRTHYSELTTLTSQYIKFISET 1477
Query: 315 -------KTSASEGNPYVSSTLSVPASPRVARKMLLASTSSCASDDFDQASYVGTNPSHS 367
+ A + L+ + ++ L + + + +A +
Sbjct: 1478 LRRMEEEERLAEQQRAEERERLAEVEAALEKQRQLAEAHAQAKAQAEREAKELQQRMQEE 1537
Query: 368 LLAGESDRVFATRRNFSCGSV-----EFDEADLES-LRQASGTPQPALR----------E 411
++ E V A ++ S + EA++++ RQA + LR +
Sbjct: 1538 VVRREEAAVDAQQQKRSIQEELQQLRQSSEAEIQAKARQAEAAERSRLRIEEEIRVVRLQ 1597
Query: 412 RKSSISSISGRDDLMDYHRRQREE-----RLREQEMERLERQ-RLETILSLCAEYTKPDS 465
+++ G + + R + EE R ++E ERL RQ + E+ AE
Sbjct: 1598 LEATERQRGGAEGELQALRARAEEAEAQKRQAQEEAERLRRQVQDESQRKRQAEVELASR 1657
Query: 466 RLSTGTTVEDVQKINKELEKLQLSDEESVFEEALMSPDTRYRCHRKDSLPDADLASCGSL 525
+ + Q+ + LE+L+L EE+ E L + + +L A ++ L
Sbjct: 1658 VKAEAEAAREKQRALQALEELRLQAEEA--ERRLRQAEVERARQVQVALETAQRSAEAEL 1715
Query: 526 SQSSASFFTPRSTRNDELLSDLTRTPPPPSSTFPKASSESSYLSILPKTPEGISEEQRSQ 585
ASF E + L R S + ++++ E E+R+Q
Sbjct: 1716 QSKRASF--------AEKTAQLER------------SLQEEHVAVAQLREEA---ERRAQ 1752
Query: 586 ELAAMEETRIVILNNLEELKQKIKDINDQMDESFRELDMECALLDGEQKSETTELMKEKE 645
+ A E R EE +++++ + +E+ R L ++ + ++ E K+KE
Sbjct: 1753 QQAEAERAR-------EEAERELERWQLKANEALR-LRLQAEEVAQQKSLAQAEAEKQKE 1804
Query: 646 ILDHLNRKIAELEKNIVGEKTKDADLLDVESKHFEDLEFQQLEHESRLDEEKENLTQQLL 705
+ R+ + E+ V ++ L+ + + E + RL E+E + +
Sbjct: 1805 EAEREARRRGKAEEQAVRQRELAEQELEKQRQLAEGTA------QQRLAAEQELIRLRAE 1858
Query: 706 REVAEYQRNIVSRKEKISALKKQANHIVQQAQREQDHFVKEKNNLIMML----QREKENL 761
E E QR ++ +E+++ L+++A Q+ Q + K + + ++L + E+E+
Sbjct: 1859 TEQGEQQRQLL--EEELARLQREAAAATQKRQELEAELAKVRAEMEVLLASKARAEEESR 1916
Query: 762 CNLEKKYSSLSGGKGFPVNPNTLKEGYISVNEINEPCGNSTNLS--PSTQFPADADAVAT 819
EK L G L E + + E L+ + + A+A+ V
Sbjct: 1917 STSEKSKQRLEAEAG---RFRELAEEAARLRALAEEAKRQRQLAEEDAARQRAEAERVLA 1973
Query: 820 EPATAV-----------LASQPQSKEH-------------FRSLEERKKQHKEGL----- 850
E A+ +A + + E+ R LEE+ QHK +
Sbjct: 1974 EKLAAIGEATRLKTEAEIALKEKEAENERLRRLAEDEAFQRRRLEEQAAQHKADIEERLA 2033
Query: 851 ---------------YLSDTLPRKKTTS----SISPHFSSATMGRSITPKAHLPLGQSNS 891
+ DTL +++ ++ F A G++ + L LG+ S
Sbjct: 2034 QLRKASDSELERQKGLVEDTLRQRRQVEEEILALKASFEKAAAGKA---ELELELGRIRS 2090
Query: 892 CG---------SVLPPSLAAMAKDSESRRMLRGYNHQQMSEGHRQKSEFYNRTASESNVY 942
+ L + E RR Q S +++ + A E
Sbjct: 2091 NAEDTLRSKEQAELEAARQRQLAAEEERRRREAEERVQKSLAAEEEAARQRKAALEEVER 2150
Query: 943 LNSFHYPDHSYKDQAFDTLSLDSSDSMETSISACSPDNISSASTSNIARIEEMERLLKQA 1002
L + +++A +S+ ++ + A + + + ++ +++ E+ L+Q
Sbjct: 2151 LKAKVEEARRLRERA----EQESARQLQLAQEA-AQKRLQAEEKAHAFAVQQKEQELQQT 2205
Query: 1003 HAEKTRLLESREREMEAKKRALEEEKR-----RREILEKRLQEETSQRQK-LIEKEVKIR 1056
++ +L+ E EA +RA EE + RE + R Q E ++R K E++ + R
Sbjct: 2206 LQQEQSVLDQLRGEAEAARRAAEEAEEARVQAEREAAQSRRQVEEAERLKQSAEEQAQAR 2265
Query: 1057 ERQRAQARPLTR 1068
+ +A A L +
Sbjct: 2266 AQAQAAAEKLRK 2277
Score = 45.1 bits (105), Expect = 4e-04
Identities = 121/724 (16%), Positives = 272/724 (37%), Gaps = 90/724 (12%)
Query: 374 DRVFATRRNFSCGSVEFDEADLESLRQASGTPQPALRERKSSISSISGRDDLMDYHRRQR 433
+ + A + +F + E +LE R S + ++ + + R + RR+R
Sbjct: 2062 EEILALKASFEKAAAGKAELELELGRIRSNAEDTLRSKEQAELEAARQRQLAAEEERRRR 2121
Query: 434 EERLREQEMERLERQRLETILSLCAEYTKPDSRLSTGTTVEDVQKINKELEKLQLSDEES 493
E R Q+ SL AE R + +E+V+++ ++E+ + E +
Sbjct: 2122 EAEERVQK-------------SLAAEEEAARQRKA---ALEEVERLKAKVEEARRLRERA 2165
Query: 494 VFEEALMSPDTRYRCHRKDSLPDADLASCGSLSQSSASFFTPRSTRNDELLSDLTRTPPP 553
E A + ++ L + A ++ Q ++ + ++ + D R
Sbjct: 2166 EQESARQLQLAQEAAQKR--LQAEEKAHAFAVQQKEQEL--QQTLQQEQSVLDQLR---G 2218
Query: 554 PSSTFPKASSESSYLSILPKTPEGISEEQ--RSQELAAMEETRIVILNNLEELKQKIKDI 611
+ +A+ E+ + + S Q ++ L E + + +K++
Sbjct: 2219 EAEAARRAAEEAEEARVQAEREAAQSRRQVEEAERLKQSAEEQAQARAQAQAAAEKLRKE 2278
Query: 612 NDQMDESFRELDMECALLDGEQKSETTELMKEKEILDHLNRKIAELEKNIVGEKTKDADL 671
+Q E+ R E A L +Q ++ E+ K K+ + R+ A++E+ + +
Sbjct: 2279 AEQ--EAARRAQAEQAALRQKQAAD-AEMEKHKKFAEQTLRQKAQVEQELTTLR------ 2329
Query: 672 LDVESKHFEDLEFQQLEHESRLDEEKENLTQQLLREVAEYQRNIVSRKEKISALKKQANH 731
L+ ++ +H+ L +E+ Q+L E E R +E++ +++ Q
Sbjct: 2330 ----------LQLEETDHQKNLLDEE---LQRLKAEATEAARQRSQVEEELFSVRVQMEE 2376
Query: 732 IVQ-QAQREQDH---FVKEKNNLIMMLQREKENLCNLEKKYSSLSGGKGFPVNPNTLKEG 787
+ + +A+ E ++ +++K+N LQ E E + + ++ + LS L E
Sbjct: 2377 LSKLKARIEAENRALILRDKDNTQRFLQEEAEKMKQVAEEAARLSVAAQEAARLRQLAEE 2436
Query: 788 YIS---------VNEINEPCGNSTNLSPSTQFPADADAVATEPATAVLASQPQSKEHF-- 836
++ + E + +T L + +A E A + + Q +
Sbjct: 2437 DLAQQRALAEKMLKEKMQAVQEATRLKAEAELLQQQKELAQEQARRLQEDKEQMAQQLAE 2496
Query: 837 ------RSLEERKKQHKEGLYLSDTLPRKKTTSSISPHFSSATMGRSITPKAHLPLGQSN 890
R+LE +++ E ++ L K + +S + A K +G+
Sbjct: 2497 ETQGFQRTLEAERQRQLEMSAEAERL--KLRVAEMSRAQARAEEDAQRFRKQAEEIGEKL 2554
Query: 891 SCGSVLPPSLAAMAKDSESRRMLRGYNHQQMSEGHRQKSEFYNRTASESNVY------LN 944
+ + + E +R ++ +++ E + + E+ + +
Sbjct: 2555 HRTELATQEKVTLVQTLEIQRQQSDHDAERLREAIAELEREKEKLQQEAKLLQLKSEEMQ 2614
Query: 945 SFHYPDHSYKDQAFDTLSLDSSDSM----------ETSISACSPDNISSASTSNIARIEE 994
+ + QA L DS+ + + D ++ A EE
Sbjct: 2615 TVQQEQLLQETQALQQSFLSEKDSLLQRERFIEQEKAKLEQLFQDEVAKAQQLR----EE 2670
Query: 995 MERLLKQAHAEKTRLLESREREMEAKKRALEEEKRRREILEKRLQEETSQRQKLIEKEVK 1054
+R +Q E+ RL+ S E + A E +R++E L++ Q+ Q + L E+ +
Sbjct: 2671 QQRQQQQMEQERQRLVASMEEARRRQHEAEEGVRRKQEELQQLEQQRRQQEELLAEENQR 2730
Query: 1055 IRER 1058
+RE+
Sbjct: 2731 LREQ 2734
Score = 41.6 bits (96), Expect = 0.005
Identities = 130/723 (17%), Positives = 291/723 (40%), Gaps = 89/723 (12%)
Query: 392 EADLESLRQASGTPQPALRERKSSISSISGRDDLMDYHRRQRE----ERLREQEMERLER 447
EA+L+S R AS + A ER ++ + RR ++ ER RE+ LER
Sbjct: 1712 EAELQSKR-ASFAEKTAQLERSLQEEHVAVAQLREEAERRAQQQAEAERAREEAERELER 1770
Query: 448 QRLETI----LSLCAEYTKPDSRLSTGTTVEDVQKINKELEKLQLSDEESVFEEALMSPD 503
+L+ L L AE L+ + ++ +E + ++E++V + L +
Sbjct: 1771 WQLKANEALRLRLQAEEVAQQKSLAQAEAEKQKEEAEREARRRGKAEEQAVRQRELAEQE 1830
Query: 504 TRYRCHRKDSLPDADLASCGSLSQSSASFFTPRSTRNDELLSD-LTRTPPPPSSTFPKAS 562
+ + LA+ L + A T + + +LL + L R ++ K
Sbjct: 1831 LEKQRQLAEGTAQQRLAAEQELIRLRAE--TEQGEQQRQLLEEELARLQREAAAATQKRQ 1888
Query: 563 SESSYLSILPKTPEGISEEQRSQELAAMEETRIVILNNLEELKQKIKDINDQMDESFREL 622
+ L+ + E + + E EE+R + E+ KQ+++ + FREL
Sbjct: 1889 ELEAELAKVRAEMEVLLASKARAE----EESR----STSEKSKQRLEAEAGR----FREL 1936
Query: 623 DMECALLDGEQKSETTELMKEKEILDH-LNRKIAELEKNIVGEKTKDADLLDVESKHFED 681
E A L ++ E +++++ + R+ AE E+ + + + ++++
Sbjct: 1937 AEEAARL----RALAEEAKRQRQLAEEDAARQRAEAERVLAEKLAAIGEATRLKTEAEIA 1992
Query: 682 LEFQQLEHES--RLDEEKENLTQQLLREVAEYQRNIVSRKEKISALKKQANHIVQQAQRE 739
L+ ++ E+E RL E++ ++L + A+++ +I +E+++ L+K ++ +++ +
Sbjct: 1993 LKEKEAENERLRRLAEDEAFQRRRLEEQAAQHKADI---EERLAQLRKASDSELERQKGL 2049
Query: 740 QDHFVKEKNNLIMMLQREKENLCNLEKKYSSLSGGKGFPVNPNTLKEGYISVNEINEPCG 799
+ ++++ + +E + L+ + + GK E + + I
Sbjct: 2050 VEDTLRQRRQV-------EEEILALKASFEKAAAGKA---------ELELELGRIRSNAE 2093
Query: 800 NSTNLSPSTQFPADADA-VATEPATAVLASQPQSKEHFRSLEERKKQHKEGLYLSDTLPR 858
++ + A +A E ++ + ++ + EE +Q K L + L
Sbjct: 2094 DTLRSKEQAELEAARQRQLAAEEERRRREAEERVQKSLAAEEEAARQRKAALEEVERLKA 2153
Query: 859 KKTTSSISPHFSSATMGRSITPKAHLPLGQSNSCGSVLPPSLAAMAKDSESRRMLRGYNH 918
K + + R + + Q + A K+ E ++ L+
Sbjct: 2154 KVEEARRLRERAEQESARQL--QLAQEAAQKRLQAEEKAHAFAVQQKEQELQQTLQ--QE 2209
Query: 919 QQMSEGHRQKSEFYNRTASESNVYLNSFHYPDHSYKDQAFDTLSLDSSDSMETSISACSP 978
Q + + R ++E R A E+ + ++ A ++ ++ ++ S +
Sbjct: 2210 QSVLDQLRGEAEAARRAAEEAE------EARVQAEREAAQSRRQVEEAERLKQSAEEQAQ 2263
Query: 979 DNISSASTSNIARIEEMERLLKQAHAEKTRLLESR----------EREMEAKKRALEEEK 1028
+ + + E+L K+A E R ++ + EME K+ E+
Sbjct: 2264 ARAQAQAAA--------EKLRKEAEQEAARRAQAEQAALRQKQAADAEMEKHKKFAEQTL 2315
Query: 1029 RRREILEKRLQ------EETSQRQKLIEKEVKIRERQRAQARPLTRY-LPVRKEDFDLRS 1081
R++ +E+ L EET ++ L+++E+ +R +A+A R V +E F +R
Sbjct: 2316 RQKAQVEQELTTLRLQLEETDHQKNLLDEEL---QRLKAEATEAARQRSQVEEELFSVRV 2372
Query: 1082 HVE 1084
+E
Sbjct: 2373 QME 2375
Score = 34.3 bits (77), Expect = 0.74
Identities = 33/108 (30%), Positives = 51/108 (47%), Gaps = 17/108 (15%)
Query: 993 EEMERLLKQAHAEKTRLLESREREMEAKKRALEEEKRR--------REILE-----KRLQ 1039
+E+E L + AE LL S+ R E + E+ K+R RE+ E + L
Sbjct: 1888 QELEAELAKVRAEMEVLLASKARAEEESRSTSEKSKQRLEAEAGRFRELAEEAARLRALA 1947
Query: 1040 EETSQRQKLIEKEVKIRERQRAQA-RPLTRYLPVRKEDFDLRSHVETA 1086
EE ++++L E++ RQRA+A R L L E L++ E A
Sbjct: 1948 EEAKRQRQLAEEDA---ARQRAEAERVLAEKLAAIGEATRLKTEAEIA 1992
>gi|41322908 plectin 1 isoform 3 [Homo sapiens]
Length = 4525
Score = 54.3 bits (129), Expect = 7e-07
Identities = 145/734 (19%), Positives = 282/734 (38%), Gaps = 81/734 (11%)
Query: 389 EFDEADLESLRQ-ASGTPQPALRERKSSISSISGRDDLMDYHRRQREERLREQEMERLER 447
E E +LE RQ A GT Q L + I + + + +++ +L E+E+ RL+R
Sbjct: 1666 ELAEQELEKQRQLAEGTAQQRLAAEQELIRLRA------ETEQGEQQRQLLEEELARLQR 1719
Query: 448 Q-------RLETILSLCAEYTKPDSRLSTGTTVEDVQKINKELEKLQLSDEESVFEEALM 500
+ R E L + + L++ E+ + E K +L E F E L
Sbjct: 1720 EAAAATQKRQELEAELAKVRAEMEVLLASKARAEEESRSTSEKSKQRLEAEAGRFRE-LA 1778
Query: 501 SPDTRYRCHRKDSLPDADLASCGSLSQSSASFFTPRSTRNDEL--LSDLTRTPPPPSSTF 558
R R +++ LA + Q + + ++L + + TR
Sbjct: 1779 EEAARLRALAEEAKRQRQLAEEDAARQRAEA----ERVLAEKLAAIGEATRLKTEAEIAL 1834
Query: 559 PKASSESSYLSILPKTPEGISEEQRSQELAAMEETRIVILNNLEELKQKIKDINDQMDES 618
+ +E+ L L + + + +R +E AA + ++EE +++ +D E
Sbjct: 1835 KEKEAENERLRRLAE--DEAFQRRRLEEQAAQHKA------DIEERLAQLRKASDSELER 1886
Query: 619 FRELDMECALLDGEQKSETTELMKEKEILDHLNRKIAELEKNIVGEKTKDADLL-DVESK 677
+ L +E L Q E E++ K + AELE + ++ D L E
Sbjct: 1887 QKGL-VEDTLRQRRQVEE--EILALKASFEKAAAGKAELELELGRIRSNAEDTLRSKEQA 1943
Query: 678 HFEDLEFQQL--EHESRLDEEKENLTQQLL--REVAEYQRNIVSRKEKISALKKQANHIV 733
E +QL E E R E +E + + L E A ++ + E++ A ++A +
Sbjct: 1944 ELEAARQRQLAAEEERRRREAEERVQKSLAAEEEAARQRKAALEEVERLKAKVEEARRLR 2003
Query: 734 QQAQREQDHFVK-------------EKNNLIMMLQREKENLCNLEKKYSSLSGGKGFPVN 780
++A++E ++ EK + + Q+E+E L+++ S L +G
Sbjct: 2004 ERAEQESARQLQLAQEAAQKRLQAEEKAHAFAVQQKEQELQQTLQQEQSVLDQLRGEAEA 2063
Query: 781 PNTLKEGY--ISVNEINEPCGNSTNLSPSTQFPADADAVATEPATAVLASQPQSKEHFRS 838
E V E + + + + A+ A A A A++ KE +
Sbjct: 2064 ARRAAEEAEEARVQAEREAAQSRRQVEEAERLKQSAEEQAQARAQAQAAAEKLRKEAEQE 2123
Query: 839 LEERKKQHKEGL---YLSDTLPRKKTTSSISPHFSSATMGRSITPKAHLPLGQSNSCGSV 895
R + + L +D K + A + + +T L L +++ ++
Sbjct: 2124 AARRAQAEQAALRQKQAADAEMEKHKKFAEQTLRQKAQVEQELTT-LRLQLEETDHQKNL 2182
Query: 896 LPPSLAAMAKDSESRRMLRGYNHQQMSEGHRQKSEFYN---RTASESNVYLNSFHYPDHS 952
L L + ++ R +++ Q E R +E+ +
Sbjct: 2183 LDEELQRLKAEATEAARQRSQVEEELFSVRVQMEELSKLKARIEAENRALILRDKDNTQR 2242
Query: 953 YKDQAFDTLSLDSSDSMETSISACSPDNISSASTSNIARIEEM-ERLLK---QAHAEKTR 1008
+ + + + + ++ S++A + + ++A+ + E++LK QA E TR
Sbjct: 2243 FLQEEAEKMKQVAEEAARLSVAAQEAARLRQLAEEDLAQQRALAEKMLKEKMQAVQEATR 2302
Query: 1009 LLESREREMEAKKRALEEEKRRREILEK---RLQEETSQRQKLIEKE------------- 1052
L E + K+ A E+ +R +E E+ +L EET Q+ +E E
Sbjct: 2303 LKAEAELLQQQKELAQEQARRLQEDKEQMAQQLAEETQGFQRTLEAERQRQLEMSAEAER 2362
Query: 1053 --VKIRERQRAQAR 1064
+++ E RAQAR
Sbjct: 2363 LKLRVAEMSRAQAR 2376
Score = 48.5 bits (114), Expect = 4e-05
Identities = 50/211 (23%), Positives = 100/211 (47%), Gaps = 28/211 (13%)
Query: 573 KTPEGISEEQRSQELAAMEETRIVILNNLEELKQKIKDINDQMDESFRELDMECALLDGE 632
K E I E+ ELA E ++ ++ LE +Q+ +++ E+ EL+ E L E
Sbjct: 2386 KQAEEIGEKLHRTELATQE--KVTLVQTLEIQRQQSDHDAERLREAIAELEREKEKLQQE 2443
Query: 633 QK-----SETTELMKEKEILDH--------LNRK--IAELEKNIVGEKTKDADLLDVESK 677
K SE + ++++++L L+ K + + E+ I EK K L E
Sbjct: 2444 AKLLQLKSEEMQTVQQEQLLQETQALQQSFLSEKDSLLQRERFIEQEKAKLEQLFQDEVA 2503
Query: 678 HFEDLEFQQLEHESRLDEEKENLTQQLLREVAEYQRNIVSRKEKISALKKQANHIVQQAQ 737
+ L +Q + ++++E+ Q+L+ + E +R +E + +++ + QQ +
Sbjct: 2504 KAQQLREEQQRQQQQMEQER----QRLVASMEEARRRQHEAEEGVRRKQEELQQLEQQ-R 2558
Query: 738 REQDHFVKEKNNLIMMLQREKENLCNLEKKY 768
R+Q+ + E+N QR +E L LE+++
Sbjct: 2559 RQQEELLAEEN------QRLREQLQLLEEQH 2583
Score = 45.1 bits (105), Expect = 4e-04
Identities = 176/972 (18%), Positives = 367/972 (37%), Gaps = 169/972 (17%)
Query: 200 SMPSSPKQARKMSIQDSLALQPKLTRHKELASENINLRTRKYSSSSLSHMGAYSRSLPRL 259
+MP + QA + ++ AL ++ RH E E ++++ ++ + Y L
Sbjct: 1213 AMPLADSQAVREQLRQEQALLEEIERHGEKVEE-----CQRFAKQYINAIKDYELQLV-T 1266
Query: 260 YRATENQLTPLSLPPRNSLGNSKRTKLGEKDLPHSVID-NDNYLNFSSLSSGALPY---- 314
Y+A QL P++ P + + + G + + +D +Y ++L+S + +
Sbjct: 1267 YKA---QLEPVASPAK-----KPKVQSGSESVIQEYVDLRTHYSELTTLTSQYIKFISET 1318
Query: 315 -------KTSASEGNPYVSSTLSVPASPRVARKMLLASTSSCASDDFDQASYVGTNPSHS 367
+ A + L+ + ++ L + + + +A +
Sbjct: 1319 LRRMEEEERLAEQQRAEERERLAEVEAALEKQRQLAEAHAQAKAQAEREAKELQQRMQEE 1378
Query: 368 LLAGESDRVFATRRNFSCGSV-----EFDEADLES-LRQASGTPQPALR----------E 411
++ E V A ++ S + EA++++ RQA + LR +
Sbjct: 1379 VVRREEAAVDAQQQKRSIQEELQQLRQSSEAEIQAKARQAEAAERSRLRIEEEIRVVRLQ 1438
Query: 412 RKSSISSISGRDDLMDYHRRQREE-----RLREQEMERLERQ-RLETILSLCAEYTKPDS 465
+++ G + + R + EE R ++E ERL RQ + E+ AE
Sbjct: 1439 LEATERQRGGAEGELQALRARAEEAEAQKRQAQEEAERLRRQVQDESQRKRQAEVELASR 1498
Query: 466 RLSTGTTVEDVQKINKELEKLQLSDEESVFEEALMSPDTRYRCHRKDSLPDADLASCGSL 525
+ + Q+ + LE+L+L EE+ E L + + +L A ++ L
Sbjct: 1499 VKAEAEAAREKQRALQALEELRLQAEEA--ERRLRQAEVERARQVQVALETAQRSAEAEL 1556
Query: 526 SQSSASFFTPRSTRNDELLSDLTRTPPPPSSTFPKASSESSYLSILPKTPEGISEEQRSQ 585
ASF E + L R S + ++++ E E+R+Q
Sbjct: 1557 QSKRASF--------AEKTAQLER------------SLQEEHVAVAQLREEA---ERRAQ 1593
Query: 586 ELAAMEETRIVILNNLEELKQKIKDINDQMDESFRELDMECALLDGEQKSETTELMKEKE 645
+ A E R EE +++++ + +E+ R L ++ + ++ E K+KE
Sbjct: 1594 QQAEAERAR-------EEAERELERWQLKANEALR-LRLQAEEVAQQKSLAQAEAEKQKE 1645
Query: 646 ILDHLNRKIAELEKNIVGEKTKDADLLDVESKHFEDLEFQQLEHESRLDEEKENLTQQLL 705
+ R+ + E+ V ++ L+ + + E + RL E+E + +
Sbjct: 1646 EAEREARRRGKAEEQAVRQRELAEQELEKQRQLAEGTA------QQRLAAEQELIRLRAE 1699
Query: 706 REVAEYQRNIVSRKEKISALKKQANHIVQQAQREQDHFVKEKNNLIMML----QREKENL 761
E E QR ++ +E+++ L+++A Q+ Q + K + + ++L + E+E+
Sbjct: 1700 TEQGEQQRQLL--EEELARLQREAAAATQKRQELEAELAKVRAEMEVLLASKARAEEESR 1757
Query: 762 CNLEKKYSSLSGGKGFPVNPNTLKEGYISVNEINEPCGNSTNLS--PSTQFPADADAVAT 819
EK L G L E + + E L+ + + A+A+ V
Sbjct: 1758 STSEKSKQRLEAEAG---RFRELAEEAARLRALAEEAKRQRQLAEEDAARQRAEAERVLA 1814
Query: 820 EPATAV-----------LASQPQSKEH-------------FRSLEERKKQHKEGL----- 850
E A+ +A + + E+ R LEE+ QHK +
Sbjct: 1815 EKLAAIGEATRLKTEAEIALKEKEAENERLRRLAEDEAFQRRRLEEQAAQHKADIEERLA 1874
Query: 851 ---------------YLSDTLPRKKTTS----SISPHFSSATMGRSITPKAHLPLGQSNS 891
+ DTL +++ ++ F A G++ + L LG+ S
Sbjct: 1875 QLRKASDSELERQKGLVEDTLRQRRQVEEEILALKASFEKAAAGKA---ELELELGRIRS 1931
Query: 892 CG---------SVLPPSLAAMAKDSESRRMLRGYNHQQMSEGHRQKSEFYNRTASESNVY 942
+ L + E RR Q S +++ + A E
Sbjct: 1932 NAEDTLRSKEQAELEAARQRQLAAEEERRRREAEERVQKSLAAEEEAARQRKAALEEVER 1991
Query: 943 LNSFHYPDHSYKDQAFDTLSLDSSDSMETSISACSPDNISSASTSNIARIEEMERLLKQA 1002
L + +++A +S+ ++ + A + + + ++ +++ E+ L+Q
Sbjct: 1992 LKAKVEEARRLRERA----EQESARQLQLAQEA-AQKRLQAEEKAHAFAVQQKEQELQQT 2046
Query: 1003 HAEKTRLLESREREMEAKKRALEEEKR-----RREILEKRLQEETSQRQK-LIEKEVKIR 1056
++ +L+ E EA +RA EE + RE + R Q E ++R K E++ + R
Sbjct: 2047 LQQEQSVLDQLRGEAEAARRAAEEAEEARVQAEREAAQSRRQVEEAERLKQSAEEQAQAR 2106
Query: 1057 ERQRAQARPLTR 1068
+ +A A L +
Sbjct: 2107 AQAQAAAEKLRK 2118
Score = 45.1 bits (105), Expect = 4e-04
Identities = 121/724 (16%), Positives = 272/724 (37%), Gaps = 90/724 (12%)
Query: 374 DRVFATRRNFSCGSVEFDEADLESLRQASGTPQPALRERKSSISSISGRDDLMDYHRRQR 433
+ + A + +F + E +LE R S + ++ + + R + RR+R
Sbjct: 1903 EEILALKASFEKAAAGKAELELELGRIRSNAEDTLRSKEQAELEAARQRQLAAEEERRRR 1962
Query: 434 EERLREQEMERLERQRLETILSLCAEYTKPDSRLSTGTTVEDVQKINKELEKLQLSDEES 493
E R Q+ SL AE R + +E+V+++ ++E+ + E +
Sbjct: 1963 EAEERVQK-------------SLAAEEEAARQRKA---ALEEVERLKAKVEEARRLRERA 2006
Query: 494 VFEEALMSPDTRYRCHRKDSLPDADLASCGSLSQSSASFFTPRSTRNDELLSDLTRTPPP 553
E A + ++ L + A ++ Q ++ + ++ + D R
Sbjct: 2007 EQESARQLQLAQEAAQKR--LQAEEKAHAFAVQQKEQEL--QQTLQQEQSVLDQLR---G 2059
Query: 554 PSSTFPKASSESSYLSILPKTPEGISEEQ--RSQELAAMEETRIVILNNLEELKQKIKDI 611
+ +A+ E+ + + S Q ++ L E + + +K++
Sbjct: 2060 EAEAARRAAEEAEEARVQAEREAAQSRRQVEEAERLKQSAEEQAQARAQAQAAAEKLRKE 2119
Query: 612 NDQMDESFRELDMECALLDGEQKSETTELMKEKEILDHLNRKIAELEKNIVGEKTKDADL 671
+Q E+ R E A L +Q ++ E+ K K+ + R+ A++E+ + +
Sbjct: 2120 AEQ--EAARRAQAEQAALRQKQAAD-AEMEKHKKFAEQTLRQKAQVEQELTTLR------ 2170
Query: 672 LDVESKHFEDLEFQQLEHESRLDEEKENLTQQLLREVAEYQRNIVSRKEKISALKKQANH 731
L+ ++ +H+ L +E+ Q+L E E R +E++ +++ Q
Sbjct: 2171 ----------LQLEETDHQKNLLDEE---LQRLKAEATEAARQRSQVEEELFSVRVQMEE 2217
Query: 732 IVQ-QAQREQDH---FVKEKNNLIMMLQREKENLCNLEKKYSSLSGGKGFPVNPNTLKEG 787
+ + +A+ E ++ +++K+N LQ E E + + ++ + LS L E
Sbjct: 2218 LSKLKARIEAENRALILRDKDNTQRFLQEEAEKMKQVAEEAARLSVAAQEAARLRQLAEE 2277
Query: 788 YIS---------VNEINEPCGNSTNLSPSTQFPADADAVATEPATAVLASQPQSKEHF-- 836
++ + E + +T L + +A E A + + Q +
Sbjct: 2278 DLAQQRALAEKMLKEKMQAVQEATRLKAEAELLQQQKELAQEQARRLQEDKEQMAQQLAE 2337
Query: 837 ------RSLEERKKQHKEGLYLSDTLPRKKTTSSISPHFSSATMGRSITPKAHLPLGQSN 890
R+LE +++ E ++ L K + +S + A K +G+
Sbjct: 2338 ETQGFQRTLEAERQRQLEMSAEAERL--KLRVAEMSRAQARAEEDAQRFRKQAEEIGEKL 2395
Query: 891 SCGSVLPPSLAAMAKDSESRRMLRGYNHQQMSEGHRQKSEFYNRTASESNVY------LN 944
+ + + E +R ++ +++ E + + E+ + +
Sbjct: 2396 HRTELATQEKVTLVQTLEIQRQQSDHDAERLREAIAELEREKEKLQQEAKLLQLKSEEMQ 2455
Query: 945 SFHYPDHSYKDQAFDTLSLDSSDSM----------ETSISACSPDNISSASTSNIARIEE 994
+ + QA L DS+ + + D ++ A EE
Sbjct: 2456 TVQQEQLLQETQALQQSFLSEKDSLLQRERFIEQEKAKLEQLFQDEVAKAQQLR----EE 2511
Query: 995 MERLLKQAHAEKTRLLESREREMEAKKRALEEEKRRREILEKRLQEETSQRQKLIEKEVK 1054
+R +Q E+ RL+ S E + A E +R++E L++ Q+ Q + L E+ +
Sbjct: 2512 QQRQQQQMEQERQRLVASMEEARRRQHEAEEGVRRKQEELQQLEQQRRQQEELLAEENQR 2571
Query: 1055 IRER 1058
+RE+
Sbjct: 2572 LREQ 2575
Score = 41.6 bits (96), Expect = 0.005
Identities = 130/723 (17%), Positives = 291/723 (40%), Gaps = 89/723 (12%)
Query: 392 EADLESLRQASGTPQPALRERKSSISSISGRDDLMDYHRRQRE----ERLREQEMERLER 447
EA+L+S R AS + A ER ++ + RR ++ ER RE+ LER
Sbjct: 1553 EAELQSKR-ASFAEKTAQLERSLQEEHVAVAQLREEAERRAQQQAEAERAREEAERELER 1611
Query: 448 QRLETI----LSLCAEYTKPDSRLSTGTTVEDVQKINKELEKLQLSDEESVFEEALMSPD 503
+L+ L L AE L+ + ++ +E + ++E++V + L +
Sbjct: 1612 WQLKANEALRLRLQAEEVAQQKSLAQAEAEKQKEEAEREARRRGKAEEQAVRQRELAEQE 1671
Query: 504 TRYRCHRKDSLPDADLASCGSLSQSSASFFTPRSTRNDELLSD-LTRTPPPPSSTFPKAS 562
+ + LA+ L + A T + + +LL + L R ++ K
Sbjct: 1672 LEKQRQLAEGTAQQRLAAEQELIRLRAE--TEQGEQQRQLLEEELARLQREAAAATQKRQ 1729
Query: 563 SESSYLSILPKTPEGISEEQRSQELAAMEETRIVILNNLEELKQKIKDINDQMDESFREL 622
+ L+ + E + + E EE+R + E+ KQ+++ + FREL
Sbjct: 1730 ELEAELAKVRAEMEVLLASKARAE----EESR----STSEKSKQRLEAEAGR----FREL 1777
Query: 623 DMECALLDGEQKSETTELMKEKEILDH-LNRKIAELEKNIVGEKTKDADLLDVESKHFED 681
E A L ++ E +++++ + R+ AE E+ + + + ++++
Sbjct: 1778 AEEAARL----RALAEEAKRQRQLAEEDAARQRAEAERVLAEKLAAIGEATRLKTEAEIA 1833
Query: 682 LEFQQLEHES--RLDEEKENLTQQLLREVAEYQRNIVSRKEKISALKKQANHIVQQAQRE 739
L+ ++ E+E RL E++ ++L + A+++ +I +E+++ L+K ++ +++ +
Sbjct: 1834 LKEKEAENERLRRLAEDEAFQRRRLEEQAAQHKADI---EERLAQLRKASDSELERQKGL 1890
Query: 740 QDHFVKEKNNLIMMLQREKENLCNLEKKYSSLSGGKGFPVNPNTLKEGYISVNEINEPCG 799
+ ++++ + +E + L+ + + GK E + + I
Sbjct: 1891 VEDTLRQRRQV-------EEEILALKASFEKAAAGKA---------ELELELGRIRSNAE 1934
Query: 800 NSTNLSPSTQFPADADA-VATEPATAVLASQPQSKEHFRSLEERKKQHKEGLYLSDTLPR 858
++ + A +A E ++ + ++ + EE +Q K L + L
Sbjct: 1935 DTLRSKEQAELEAARQRQLAAEEERRRREAEERVQKSLAAEEEAARQRKAALEEVERLKA 1994
Query: 859 KKTTSSISPHFSSATMGRSITPKAHLPLGQSNSCGSVLPPSLAAMAKDSESRRMLRGYNH 918
K + + R + + Q + A K+ E ++ L+
Sbjct: 1995 KVEEARRLRERAEQESARQL--QLAQEAAQKRLQAEEKAHAFAVQQKEQELQQTLQ--QE 2050
Query: 919 QQMSEGHRQKSEFYNRTASESNVYLNSFHYPDHSYKDQAFDTLSLDSSDSMETSISACSP 978
Q + + R ++E R A E+ + ++ A ++ ++ ++ S +
Sbjct: 2051 QSVLDQLRGEAEAARRAAEEAE------EARVQAEREAAQSRRQVEEAERLKQSAEEQAQ 2104
Query: 979 DNISSASTSNIARIEEMERLLKQAHAEKTRLLESR----------EREMEAKKRALEEEK 1028
+ + + E+L K+A E R ++ + EME K+ E+
Sbjct: 2105 ARAQAQAAA--------EKLRKEAEQEAARRAQAEQAALRQKQAADAEMEKHKKFAEQTL 2156
Query: 1029 RRREILEKRLQ------EETSQRQKLIEKEVKIRERQRAQARPLTRY-LPVRKEDFDLRS 1081
R++ +E+ L EET ++ L+++E+ +R +A+A R V +E F +R
Sbjct: 2157 RQKAQVEQELTTLRLQLEETDHQKNLLDEEL---QRLKAEATEAARQRSQVEEELFSVRV 2213
Query: 1082 HVE 1084
+E
Sbjct: 2214 QME 2216
Score = 34.3 bits (77), Expect = 0.74
Identities = 33/108 (30%), Positives = 51/108 (47%), Gaps = 17/108 (15%)
Query: 993 EEMERLLKQAHAEKTRLLESREREMEAKKRALEEEKRR--------REILE-----KRLQ 1039
+E+E L + AE LL S+ R E + E+ K+R RE+ E + L
Sbjct: 1729 QELEAELAKVRAEMEVLLASKARAEEESRSTSEKSKQRLEAEAGRFRELAEEAARLRALA 1788
Query: 1040 EETSQRQKLIEKEVKIRERQRAQA-RPLTRYLPVRKEDFDLRSHVETA 1086
EE ++++L E++ RQRA+A R L L E L++ E A
Sbjct: 1789 EEAKRQRQLAEEDA---ARQRAEAERVLAEKLAAIGEATRLKTEAEIA 1833
>gi|41322912 plectin 1 isoform 2 [Homo sapiens]
Length = 4533
Score = 54.3 bits (129), Expect = 7e-07
Identities = 145/734 (19%), Positives = 282/734 (38%), Gaps = 81/734 (11%)
Query: 389 EFDEADLESLRQ-ASGTPQPALRERKSSISSISGRDDLMDYHRRQREERLREQEMERLER 447
E E +LE RQ A GT Q L + I + + + +++ +L E+E+ RL+R
Sbjct: 1674 ELAEQELEKQRQLAEGTAQQRLAAEQELIRLRA------ETEQGEQQRQLLEEELARLQR 1727
Query: 448 Q-------RLETILSLCAEYTKPDSRLSTGTTVEDVQKINKELEKLQLSDEESVFEEALM 500
+ R E L + + L++ E+ + E K +L E F E L
Sbjct: 1728 EAAAATQKRQELEAELAKVRAEMEVLLASKARAEEESRSTSEKSKQRLEAEAGRFRE-LA 1786
Query: 501 SPDTRYRCHRKDSLPDADLASCGSLSQSSASFFTPRSTRNDEL--LSDLTRTPPPPSSTF 558
R R +++ LA + Q + + ++L + + TR
Sbjct: 1787 EEAARLRALAEEAKRQRQLAEEDAARQRAEA----ERVLAEKLAAIGEATRLKTEAEIAL 1842
Query: 559 PKASSESSYLSILPKTPEGISEEQRSQELAAMEETRIVILNNLEELKQKIKDINDQMDES 618
+ +E+ L L + + + +R +E AA + ++EE +++ +D E
Sbjct: 1843 KEKEAENERLRRLAE--DEAFQRRRLEEQAAQHKA------DIEERLAQLRKASDSELER 1894
Query: 619 FRELDMECALLDGEQKSETTELMKEKEILDHLNRKIAELEKNIVGEKTKDADLL-DVESK 677
+ L +E L Q E E++ K + AELE + ++ D L E
Sbjct: 1895 QKGL-VEDTLRQRRQVEE--EILALKASFEKAAAGKAELELELGRIRSNAEDTLRSKEQA 1951
Query: 678 HFEDLEFQQL--EHESRLDEEKENLTQQLL--REVAEYQRNIVSRKEKISALKKQANHIV 733
E +QL E E R E +E + + L E A ++ + E++ A ++A +
Sbjct: 1952 ELEAARQRQLAAEEERRRREAEERVQKSLAAEEEAARQRKAALEEVERLKAKVEEARRLR 2011
Query: 734 QQAQREQDHFVK-------------EKNNLIMMLQREKENLCNLEKKYSSLSGGKGFPVN 780
++A++E ++ EK + + Q+E+E L+++ S L +G
Sbjct: 2012 ERAEQESARQLQLAQEAAQKRLQAEEKAHAFAVQQKEQELQQTLQQEQSVLDQLRGEAEA 2071
Query: 781 PNTLKEGY--ISVNEINEPCGNSTNLSPSTQFPADADAVATEPATAVLASQPQSKEHFRS 838
E V E + + + + A+ A A A A++ KE +
Sbjct: 2072 ARRAAEEAEEARVQAEREAAQSRRQVEEAERLKQSAEEQAQARAQAQAAAEKLRKEAEQE 2131
Query: 839 LEERKKQHKEGL---YLSDTLPRKKTTSSISPHFSSATMGRSITPKAHLPLGQSNSCGSV 895
R + + L +D K + A + + +T L L +++ ++
Sbjct: 2132 AARRAQAEQAALRQKQAADAEMEKHKKFAEQTLRQKAQVEQELTT-LRLQLEETDHQKNL 2190
Query: 896 LPPSLAAMAKDSESRRMLRGYNHQQMSEGHRQKSEFYN---RTASESNVYLNSFHYPDHS 952
L L + ++ R +++ Q E R +E+ +
Sbjct: 2191 LDEELQRLKAEATEAARQRSQVEEELFSVRVQMEELSKLKARIEAENRALILRDKDNTQR 2250
Query: 953 YKDQAFDTLSLDSSDSMETSISACSPDNISSASTSNIARIEEM-ERLLK---QAHAEKTR 1008
+ + + + + ++ S++A + + ++A+ + E++LK QA E TR
Sbjct: 2251 FLQEEAEKMKQVAEEAARLSVAAQEAARLRQLAEEDLAQQRALAEKMLKEKMQAVQEATR 2310
Query: 1009 LLESREREMEAKKRALEEEKRRREILEK---RLQEETSQRQKLIEKE------------- 1052
L E + K+ A E+ +R +E E+ +L EET Q+ +E E
Sbjct: 2311 LKAEAELLQQQKELAQEQARRLQEDKEQMAQQLAEETQGFQRTLEAERQRQLEMSAEAER 2370
Query: 1053 --VKIRERQRAQAR 1064
+++ E RAQAR
Sbjct: 2371 LKLRVAEMSRAQAR 2384
Score = 48.5 bits (114), Expect = 4e-05
Identities = 50/211 (23%), Positives = 100/211 (47%), Gaps = 28/211 (13%)
Query: 573 KTPEGISEEQRSQELAAMEETRIVILNNLEELKQKIKDINDQMDESFRELDMECALLDGE 632
K E I E+ ELA E ++ ++ LE +Q+ +++ E+ EL+ E L E
Sbjct: 2394 KQAEEIGEKLHRTELATQE--KVTLVQTLEIQRQQSDHDAERLREAIAELEREKEKLQQE 2451
Query: 633 QK-----SETTELMKEKEILDH--------LNRK--IAELEKNIVGEKTKDADLLDVESK 677
K SE + ++++++L L+ K + + E+ I EK K L E
Sbjct: 2452 AKLLQLKSEEMQTVQQEQLLQETQALQQSFLSEKDSLLQRERFIEQEKAKLEQLFQDEVA 2511
Query: 678 HFEDLEFQQLEHESRLDEEKENLTQQLLREVAEYQRNIVSRKEKISALKKQANHIVQQAQ 737
+ L +Q + ++++E+ Q+L+ + E +R +E + +++ + QQ +
Sbjct: 2512 KAQQLREEQQRQQQQMEQER----QRLVASMEEARRRQHEAEEGVRRKQEELQQLEQQ-R 2566
Query: 738 REQDHFVKEKNNLIMMLQREKENLCNLEKKY 768
R+Q+ + E+N QR +E L LE+++
Sbjct: 2567 RQQEELLAEEN------QRLREQLQLLEEQH 2591
Score = 45.1 bits (105), Expect = 4e-04
Identities = 176/972 (18%), Positives = 367/972 (37%), Gaps = 169/972 (17%)
Query: 200 SMPSSPKQARKMSIQDSLALQPKLTRHKELASENINLRTRKYSSSSLSHMGAYSRSLPRL 259
+MP + QA + ++ AL ++ RH E E ++++ ++ + Y L
Sbjct: 1221 AMPLADSQAVREQLRQEQALLEEIERHGEKVEE-----CQRFAKQYINAIKDYELQLV-T 1274
Query: 260 YRATENQLTPLSLPPRNSLGNSKRTKLGEKDLPHSVID-NDNYLNFSSLSSGALPY---- 314
Y+A QL P++ P + + + G + + +D +Y ++L+S + +
Sbjct: 1275 YKA---QLEPVASPAK-----KPKVQSGSESVIQEYVDLRTHYSELTTLTSQYIKFISET 1326
Query: 315 -------KTSASEGNPYVSSTLSVPASPRVARKMLLASTSSCASDDFDQASYVGTNPSHS 367
+ A + L+ + ++ L + + + +A +
Sbjct: 1327 LRRMEEEERLAEQQRAEERERLAEVEAALEKQRQLAEAHAQAKAQAEREAKELQQRMQEE 1386
Query: 368 LLAGESDRVFATRRNFSCGSV-----EFDEADLES-LRQASGTPQPALR----------E 411
++ E V A ++ S + EA++++ RQA + LR +
Sbjct: 1387 VVRREEAAVDAQQQKRSIQEELQQLRQSSEAEIQAKARQAEAAERSRLRIEEEIRVVRLQ 1446
Query: 412 RKSSISSISGRDDLMDYHRRQREE-----RLREQEMERLERQ-RLETILSLCAEYTKPDS 465
+++ G + + R + EE R ++E ERL RQ + E+ AE
Sbjct: 1447 LEATERQRGGAEGELQALRARAEEAEAQKRQAQEEAERLRRQVQDESQRKRQAEVELASR 1506
Query: 466 RLSTGTTVEDVQKINKELEKLQLSDEESVFEEALMSPDTRYRCHRKDSLPDADLASCGSL 525
+ + Q+ + LE+L+L EE+ E L + + +L A ++ L
Sbjct: 1507 VKAEAEAAREKQRALQALEELRLQAEEA--ERRLRQAEVERARQVQVALETAQRSAEAEL 1564
Query: 526 SQSSASFFTPRSTRNDELLSDLTRTPPPPSSTFPKASSESSYLSILPKTPEGISEEQRSQ 585
ASF E + L R S + ++++ E E+R+Q
Sbjct: 1565 QSKRASF--------AEKTAQLER------------SLQEEHVAVAQLREEA---ERRAQ 1601
Query: 586 ELAAMEETRIVILNNLEELKQKIKDINDQMDESFRELDMECALLDGEQKSETTELMKEKE 645
+ A E R EE +++++ + +E+ R L ++ + ++ E K+KE
Sbjct: 1602 QQAEAERAR-------EEAERELERWQLKANEALR-LRLQAEEVAQQKSLAQAEAEKQKE 1653
Query: 646 ILDHLNRKIAELEKNIVGEKTKDADLLDVESKHFEDLEFQQLEHESRLDEEKENLTQQLL 705
+ R+ + E+ V ++ L+ + + E + RL E+E + +
Sbjct: 1654 EAEREARRRGKAEEQAVRQRELAEQELEKQRQLAEGTA------QQRLAAEQELIRLRAE 1707
Query: 706 REVAEYQRNIVSRKEKISALKKQANHIVQQAQREQDHFVKEKNNLIMML----QREKENL 761
E E QR ++ +E+++ L+++A Q+ Q + K + + ++L + E+E+
Sbjct: 1708 TEQGEQQRQLL--EEELARLQREAAAATQKRQELEAELAKVRAEMEVLLASKARAEEESR 1765
Query: 762 CNLEKKYSSLSGGKGFPVNPNTLKEGYISVNEINEPCGNSTNLS--PSTQFPADADAVAT 819
EK L G L E + + E L+ + + A+A+ V
Sbjct: 1766 STSEKSKQRLEAEAG---RFRELAEEAARLRALAEEAKRQRQLAEEDAARQRAEAERVLA 1822
Query: 820 EPATAV-----------LASQPQSKEH-------------FRSLEERKKQHKEGL----- 850
E A+ +A + + E+ R LEE+ QHK +
Sbjct: 1823 EKLAAIGEATRLKTEAEIALKEKEAENERLRRLAEDEAFQRRRLEEQAAQHKADIEERLA 1882
Query: 851 ---------------YLSDTLPRKKTTS----SISPHFSSATMGRSITPKAHLPLGQSNS 891
+ DTL +++ ++ F A G++ + L LG+ S
Sbjct: 1883 QLRKASDSELERQKGLVEDTLRQRRQVEEEILALKASFEKAAAGKA---ELELELGRIRS 1939
Query: 892 CG---------SVLPPSLAAMAKDSESRRMLRGYNHQQMSEGHRQKSEFYNRTASESNVY 942
+ L + E RR Q S +++ + A E
Sbjct: 1940 NAEDTLRSKEQAELEAARQRQLAAEEERRRREAEERVQKSLAAEEEAARQRKAALEEVER 1999
Query: 943 LNSFHYPDHSYKDQAFDTLSLDSSDSMETSISACSPDNISSASTSNIARIEEMERLLKQA 1002
L + +++A +S+ ++ + A + + + ++ +++ E+ L+Q
Sbjct: 2000 LKAKVEEARRLRERA----EQESARQLQLAQEA-AQKRLQAEEKAHAFAVQQKEQELQQT 2054
Query: 1003 HAEKTRLLESREREMEAKKRALEEEKR-----RREILEKRLQEETSQRQK-LIEKEVKIR 1056
++ +L+ E EA +RA EE + RE + R Q E ++R K E++ + R
Sbjct: 2055 LQQEQSVLDQLRGEAEAARRAAEEAEEARVQAEREAAQSRRQVEEAERLKQSAEEQAQAR 2114
Query: 1057 ERQRAQARPLTR 1068
+ +A A L +
Sbjct: 2115 AQAQAAAEKLRK 2126
Score = 45.1 bits (105), Expect = 4e-04
Identities = 121/724 (16%), Positives = 272/724 (37%), Gaps = 90/724 (12%)
Query: 374 DRVFATRRNFSCGSVEFDEADLESLRQASGTPQPALRERKSSISSISGRDDLMDYHRRQR 433
+ + A + +F + E +LE R S + ++ + + R + RR+R
Sbjct: 1911 EEILALKASFEKAAAGKAELELELGRIRSNAEDTLRSKEQAELEAARQRQLAAEEERRRR 1970
Query: 434 EERLREQEMERLERQRLETILSLCAEYTKPDSRLSTGTTVEDVQKINKELEKLQLSDEES 493
E R Q+ SL AE R + +E+V+++ ++E+ + E +
Sbjct: 1971 EAEERVQK-------------SLAAEEEAARQRKA---ALEEVERLKAKVEEARRLRERA 2014
Query: 494 VFEEALMSPDTRYRCHRKDSLPDADLASCGSLSQSSASFFTPRSTRNDELLSDLTRTPPP 553
E A + ++ L + A ++ Q ++ + ++ + D R
Sbjct: 2015 EQESARQLQLAQEAAQKR--LQAEEKAHAFAVQQKEQEL--QQTLQQEQSVLDQLR---G 2067
Query: 554 PSSTFPKASSESSYLSILPKTPEGISEEQ--RSQELAAMEETRIVILNNLEELKQKIKDI 611
+ +A+ E+ + + S Q ++ L E + + +K++
Sbjct: 2068 EAEAARRAAEEAEEARVQAEREAAQSRRQVEEAERLKQSAEEQAQARAQAQAAAEKLRKE 2127
Query: 612 NDQMDESFRELDMECALLDGEQKSETTELMKEKEILDHLNRKIAELEKNIVGEKTKDADL 671
+Q E+ R E A L +Q ++ E+ K K+ + R+ A++E+ + +
Sbjct: 2128 AEQ--EAARRAQAEQAALRQKQAAD-AEMEKHKKFAEQTLRQKAQVEQELTTLR------ 2178
Query: 672 LDVESKHFEDLEFQQLEHESRLDEEKENLTQQLLREVAEYQRNIVSRKEKISALKKQANH 731
L+ ++ +H+ L +E+ Q+L E E R +E++ +++ Q
Sbjct: 2179 ----------LQLEETDHQKNLLDEE---LQRLKAEATEAARQRSQVEEELFSVRVQMEE 2225
Query: 732 IVQ-QAQREQDH---FVKEKNNLIMMLQREKENLCNLEKKYSSLSGGKGFPVNPNTLKEG 787
+ + +A+ E ++ +++K+N LQ E E + + ++ + LS L E
Sbjct: 2226 LSKLKARIEAENRALILRDKDNTQRFLQEEAEKMKQVAEEAARLSVAAQEAARLRQLAEE 2285
Query: 788 YIS---------VNEINEPCGNSTNLSPSTQFPADADAVATEPATAVLASQPQSKEHF-- 836
++ + E + +T L + +A E A + + Q +
Sbjct: 2286 DLAQQRALAEKMLKEKMQAVQEATRLKAEAELLQQQKELAQEQARRLQEDKEQMAQQLAE 2345
Query: 837 ------RSLEERKKQHKEGLYLSDTLPRKKTTSSISPHFSSATMGRSITPKAHLPLGQSN 890
R+LE +++ E ++ L K + +S + A K +G+
Sbjct: 2346 ETQGFQRTLEAERQRQLEMSAEAERL--KLRVAEMSRAQARAEEDAQRFRKQAEEIGEKL 2403
Query: 891 SCGSVLPPSLAAMAKDSESRRMLRGYNHQQMSEGHRQKSEFYNRTASESNVY------LN 944
+ + + E +R ++ +++ E + + E+ + +
Sbjct: 2404 HRTELATQEKVTLVQTLEIQRQQSDHDAERLREAIAELEREKEKLQQEAKLLQLKSEEMQ 2463
Query: 945 SFHYPDHSYKDQAFDTLSLDSSDSM----------ETSISACSPDNISSASTSNIARIEE 994
+ + QA L DS+ + + D ++ A EE
Sbjct: 2464 TVQQEQLLQETQALQQSFLSEKDSLLQRERFIEQEKAKLEQLFQDEVAKAQQLR----EE 2519
Query: 995 MERLLKQAHAEKTRLLESREREMEAKKRALEEEKRRREILEKRLQEETSQRQKLIEKEVK 1054
+R +Q E+ RL+ S E + A E +R++E L++ Q+ Q + L E+ +
Sbjct: 2520 QQRQQQQMEQERQRLVASMEEARRRQHEAEEGVRRKQEELQQLEQQRRQQEELLAEENQR 2579
Query: 1055 IRER 1058
+RE+
Sbjct: 2580 LREQ 2583
Score = 41.6 bits (96), Expect = 0.005
Identities = 130/723 (17%), Positives = 291/723 (40%), Gaps = 89/723 (12%)
Query: 392 EADLESLRQASGTPQPALRERKSSISSISGRDDLMDYHRRQRE----ERLREQEMERLER 447
EA+L+S R AS + A ER ++ + RR ++ ER RE+ LER
Sbjct: 1561 EAELQSKR-ASFAEKTAQLERSLQEEHVAVAQLREEAERRAQQQAEAERAREEAERELER 1619
Query: 448 QRLETI----LSLCAEYTKPDSRLSTGTTVEDVQKINKELEKLQLSDEESVFEEALMSPD 503
+L+ L L AE L+ + ++ +E + ++E++V + L +
Sbjct: 1620 WQLKANEALRLRLQAEEVAQQKSLAQAEAEKQKEEAEREARRRGKAEEQAVRQRELAEQE 1679
Query: 504 TRYRCHRKDSLPDADLASCGSLSQSSASFFTPRSTRNDELLSD-LTRTPPPPSSTFPKAS 562
+ + LA+ L + A T + + +LL + L R ++ K
Sbjct: 1680 LEKQRQLAEGTAQQRLAAEQELIRLRAE--TEQGEQQRQLLEEELARLQREAAAATQKRQ 1737
Query: 563 SESSYLSILPKTPEGISEEQRSQELAAMEETRIVILNNLEELKQKIKDINDQMDESFREL 622
+ L+ + E + + E EE+R + E+ KQ+++ + FREL
Sbjct: 1738 ELEAELAKVRAEMEVLLASKARAE----EESR----STSEKSKQRLEAEAGR----FREL 1785
Query: 623 DMECALLDGEQKSETTELMKEKEILDH-LNRKIAELEKNIVGEKTKDADLLDVESKHFED 681
E A L ++ E +++++ + R+ AE E+ + + + ++++
Sbjct: 1786 AEEAARL----RALAEEAKRQRQLAEEDAARQRAEAERVLAEKLAAIGEATRLKTEAEIA 1841
Query: 682 LEFQQLEHES--RLDEEKENLTQQLLREVAEYQRNIVSRKEKISALKKQANHIVQQAQRE 739
L+ ++ E+E RL E++ ++L + A+++ +I +E+++ L+K ++ +++ +
Sbjct: 1842 LKEKEAENERLRRLAEDEAFQRRRLEEQAAQHKADI---EERLAQLRKASDSELERQKGL 1898
Query: 740 QDHFVKEKNNLIMMLQREKENLCNLEKKYSSLSGGKGFPVNPNTLKEGYISVNEINEPCG 799
+ ++++ + +E + L+ + + GK E + + I
Sbjct: 1899 VEDTLRQRRQV-------EEEILALKASFEKAAAGKA---------ELELELGRIRSNAE 1942
Query: 800 NSTNLSPSTQFPADADA-VATEPATAVLASQPQSKEHFRSLEERKKQHKEGLYLSDTLPR 858
++ + A +A E ++ + ++ + EE +Q K L + L
Sbjct: 1943 DTLRSKEQAELEAARQRQLAAEEERRRREAEERVQKSLAAEEEAARQRKAALEEVERLKA 2002
Query: 859 KKTTSSISPHFSSATMGRSITPKAHLPLGQSNSCGSVLPPSLAAMAKDSESRRMLRGYNH 918
K + + R + + Q + A K+ E ++ L+
Sbjct: 2003 KVEEARRLRERAEQESARQL--QLAQEAAQKRLQAEEKAHAFAVQQKEQELQQTLQ--QE 2058
Query: 919 QQMSEGHRQKSEFYNRTASESNVYLNSFHYPDHSYKDQAFDTLSLDSSDSMETSISACSP 978
Q + + R ++E R A E+ + ++ A ++ ++ ++ S +
Sbjct: 2059 QSVLDQLRGEAEAARRAAEEAE------EARVQAEREAAQSRRQVEEAERLKQSAEEQAQ 2112
Query: 979 DNISSASTSNIARIEEMERLLKQAHAEKTRLLESR----------EREMEAKKRALEEEK 1028
+ + + E+L K+A E R ++ + EME K+ E+
Sbjct: 2113 ARAQAQAAA--------EKLRKEAEQEAARRAQAEQAALRQKQAADAEMEKHKKFAEQTL 2164
Query: 1029 RRREILEKRLQ------EETSQRQKLIEKEVKIRERQRAQARPLTRY-LPVRKEDFDLRS 1081
R++ +E+ L EET ++ L+++E+ +R +A+A R V +E F +R
Sbjct: 2165 RQKAQVEQELTTLRLQLEETDHQKNLLDEEL---QRLKAEATEAARQRSQVEEELFSVRV 2221
Query: 1082 HVE 1084
+E
Sbjct: 2222 QME 2224
Score = 34.3 bits (77), Expect = 0.74
Identities = 33/108 (30%), Positives = 51/108 (47%), Gaps = 17/108 (15%)
Query: 993 EEMERLLKQAHAEKTRLLESREREMEAKKRALEEEKRR--------REILE-----KRLQ 1039
+E+E L + AE LL S+ R E + E+ K+R RE+ E + L
Sbjct: 1737 QELEAELAKVRAEMEVLLASKARAEEESRSTSEKSKQRLEAEAGRFRELAEEAARLRALA 1796
Query: 1040 EETSQRQKLIEKEVKIRERQRAQA-RPLTRYLPVRKEDFDLRSHVETA 1086
EE ++++L E++ RQRA+A R L L E L++ E A
Sbjct: 1797 EEAKRQRQLAEEDA---ARQRAEAERVLAEKLAAIGEATRLKTEAEIA 1841
Database: hs.faa
Posted date: Aug 4, 2009 4:42 PM
Number of letters in database: 18,247,518
Number of sequences in database: 37,866
Lambda K H
0.310 0.126 0.348
Gapped
Lambda K H
0.267 0.0410 0.140
Matrix: BLOSUM62
Gap Penalties: Existence: 11, Extension: 1
Number of Hits to DB: 47,009,999
Number of Sequences: 37866
Number of extensions: 2286949
Number of successful extensions: 21611
Number of sequences better than 10.0: 30
Number of HSP's better than 10.0 without gapping: 310
Number of HSP's successfully gapped in prelim test: 891
Number of HSP's that attempted gapping in prelim test: 11869
Number of HSP's gapped (non-prelim): 8000
length of query: 1210
length of database: 18,247,518
effective HSP length: 114
effective length of query: 1096
effective length of database: 13,930,794
effective search space: 15268150224
effective search space used: 15268150224
T: 11
A: 40
X1: 16 ( 7.2 bits)
X2: 38 (14.6 bits)
X3: 64 (24.7 bits)
S1: 42 (21.8 bits)
S2: 68 (30.8 bits)
Search results were obtained with NCBI BLAST and RefSeq entries.
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Guide to the Human Genome
Copyright © 2010 by Stewart Scherer. All rights reserved.