Search of human proteins with 218156328

Search of human proteins with 218156328

BLASTP 2.2.11 [Jun-05-2005]


Reference: Altschul, Stephen F., Thomas L. Madden, Alejandro A. Schaffer, 
Jinghui Zhang, Zheng Zhang, Webb Miller, and David J. Lipman (1997), 
"Gapped BLAST and PSI-BLAST: a new generation of protein database search
programs",  Nucleic Acids Res. 25:3389-3402.

Query= gi|218156328 glycine receptor, alpha 4 precursor [Homo sapiens]
         (417 letters)

Database: hs.faa 
           37,866 sequences; 18,247,518 total letters

Searching..................................................done

                                                                 Score    E
Sequences producing significant alignments:                      (bits) Value

gi|218156328 glycine receptor, alpha 4 precursor [Homo sapiens]       847   0.0  
gi|169646723 glycine receptor, alpha 2 isoform A [Homo sapiens]       658   0.0  
gi|4504021 glycine receptor, alpha 2 isoform A [Homo sapiens]         658   0.0  
gi|169646728 glycine receptor, alpha 2 isoform B [Homo sapiens]       657   0.0  
gi|110347433 glycine receptor, alpha 3 isoform b [Homo sapiens]       630   0.0  
gi|110347441 glycine receptor, alpha 3 isoform a [Homo sapiens]       625   e-179
gi|119372310 glycine receptor, alpha 1 isoform 2 precursor [Homo...   616   e-176
gi|225903367 glycine receptor, alpha 1 isoform 1 precursor [Homo...   615   e-176
gi|4504023 glycine receptor, beta [Homo sapiens]                      335   5e-92
gi|12548788 gamma-aminobutyric acid (GABA) A receptor, beta 3 is...   282   5e-76
gi|4503865 gamma-aminobutyric acid (GABA) A receptor, beta 2 iso...   280   2e-75
gi|12548785 gamma-aminobutyric acid (GABA) A receptor, beta 2 is...   280   2e-75
gi|194097327 gamma-aminobutyric acid (GABA) A receptor, beta 1 p...   276   2e-74
gi|4503867 gamma-aminobutyric acid (GABA) A receptor, beta 3 iso...   275   6e-74
gi|34734071 gamma-aminobutyric acid (GABA) A receptor, delta pre...   271   8e-73
gi|7657106 gamma-aminobutyric acid (GABA) A receptor, pi [Homo s...   260   1e-69
gi|153266866 gamma-aminobutyric acid (GABA) receptor, rho 2 prec...   258   5e-69
gi|8924258 gamma-aminobutyric acid (GABA) receptor, theta precur...   255   6e-68
gi|194097386 gamma-aminobutyric acid (GABA) receptor, rho 1 [Hom...   253   2e-67
gi|157389018 gamma-aminobutyric acid A receptor, alpha 6 precurs...   251   9e-67
gi|38788135 gamma-aminobutyric acid A receptor, gamma 2 isoform ...   248   7e-66
gi|38788155 gamma-aminobutyric acid A receptor, gamma 2 isoform ...   248   7e-66
gi|34452723 gamma-aminobutyric acid A receptor, alpha 4 precurso...   248   7e-66
gi|167000817 gamma-aminobutyric acid A receptor, alpha 2 [Homo s...   246   4e-65
gi|167000751 gamma-aminobutyric acid A receptor, alpha 2 precurs...   246   4e-65
gi|110347416 gamma-aminobutyric acid (GABA) A receptor, gamma 3 ...   246   4e-65
gi|31742490 gamma-aminobutyric acid A receptor, gamma 1 precurso...   245   5e-65
gi|157743288 gamma-aminobutyric acid (GABA) receptor, rho 3 [Hom...   245   6e-65
gi|189083734 gamma-aminobutyric acid (GABA) A receptor, alpha 1 ...   244   1e-64
gi|189083732 gamma-aminobutyric acid (GABA) A receptor, alpha 1 ...   244   1e-64

>gi|218156328 glycine receptor, alpha 4 precursor [Homo sapiens]
          Length = 417

 Score =  847 bits (2187), Expect = 0.0
 Identities = 417/417 (100%), Positives = 417/417 (100%)

Query: 1   MTTLVPATLSFLLLWTLPGQVLLRVALAKEEVKSGTKGSQPMSPSDFLDKLMGRTSGYDA 60
           MTTLVPATLSFLLLWTLPGQVLLRVALAKEEVKSGTKGSQPMSPSDFLDKLMGRTSGYDA
Sbjct: 1   MTTLVPATLSFLLLWTLPGQVLLRVALAKEEVKSGTKGSQPMSPSDFLDKLMGRTSGYDA 60

Query: 61  RIRPNFKGPPVNVTCNIFINSFSSITKTTMDYRVNVFLRQQWNDPRLSYREYPDDSLDLD 120
           RIRPNFKGPPVNVTCNIFINSFSSITKTTMDYRVNVFLRQQWNDPRLSYREYPDDSLDLD
Sbjct: 61  RIRPNFKGPPVNVTCNIFINSFSSITKTTMDYRVNVFLRQQWNDPRLSYREYPDDSLDLD 120

Query: 121 PSMLDSIWKPDLFFANEKGANFHEVTTDNKLLRIFKNGNVLYSIRLTLILSCLMDLKNFP 180
           PSMLDSIWKPDLFFANEKGANFHEVTTDNKLLRIFKNGNVLYSIRLTLILSCLMDLKNFP
Sbjct: 121 PSMLDSIWKPDLFFANEKGANFHEVTTDNKLLRIFKNGNVLYSIRLTLILSCLMDLKNFP 180

Query: 181 MDIQTCTMQLESFGYTMKDLVFEWLEDAPAVQVAEGLTLPQFILRDEKDLGCCTKHYNTG 240
           MDIQTCTMQLESFGYTMKDLVFEWLEDAPAVQVAEGLTLPQFILRDEKDLGCCTKHYNTG
Sbjct: 181 MDIQTCTMQLESFGYTMKDLVFEWLEDAPAVQVAEGLTLPQFILRDEKDLGCCTKHYNTG 240

Query: 241 KFTCIEVKFHLERQMGYYLIQMYIPSLLIVILSWVSFWINMDAAPARVGLGITTVLTMTT 300
           KFTCIEVKFHLERQMGYYLIQMYIPSLLIVILSWVSFWINMDAAPARVGLGITTVLTMTT
Sbjct: 241 KFTCIEVKFHLERQMGYYLIQMYIPSLLIVILSWVSFWINMDAAPARVGLGITTVLTMTT 300

Query: 301 QSSGSRASLPKVSYVKAIDIWMAVCLLFVFAALLEYAAINFVSRQHKEFIRLRRRQRRQR 360
           QSSGSRASLPKVSYVKAIDIWMAVCLLFVFAALLEYAAINFVSRQHKEFIRLRRRQRRQR
Sbjct: 301 QSSGSRASLPKVSYVKAIDIWMAVCLLFVFAALLEYAAINFVSRQHKEFIRLRRRQRRQR 360

Query: 361 LEEDIIQESRFYFRGYGLGHCLQARDGGPMEGSGIYSPQPPAPLLREGETTRKLYVD 417
           LEEDIIQESRFYFRGYGLGHCLQARDGGPMEGSGIYSPQPPAPLLREGETTRKLYVD
Sbjct: 361 LEEDIIQESRFYFRGYGLGHCLQARDGGPMEGSGIYSPQPPAPLLREGETTRKLYVD 417


>gi|169646723 glycine receptor, alpha 2 isoform A [Homo sapiens]
          Length = 452

 Score =  658 bits (1698), Expect = 0.0
 Identities = 324/396 (81%), Positives = 354/396 (89%), Gaps = 7/396 (1%)

Query: 24  RVALAKE-EVKSGTKGSQPMSPSDFLDKLMGRTSGYDARIRPNFKGPPVNVTCNIFINSF 82
           R A  K+ + +SG + SQ +SPSDFLDKLMGRTSGYDARIRPNFKGPPVNVTCNIFINSF
Sbjct: 23  RTAFCKDHDSRSGKQPSQTLSPSDFLDKLMGRTSGYDARIRPNFKGPPVNVTCNIFINSF 82

Query: 83  SSITKTTMDYRVNVFLRQQWNDPRLSYREYPDDSLDLDPSMLDSIWKPDLFFANEKGANF 142
            S+T+TTMDYRVN+FLRQQWND RL+Y EYPDDSLDLDPSMLDSIWKPDLFFANEKGANF
Sbjct: 83  GSVTETTMDYRVNIFLRQQWNDSRLAYSEYPDDSLDLDPSMLDSIWKPDLFFANEKGANF 142

Query: 143 HEVTTDNKLLRIFKNGNVLYSIRLTLILSCLMDLKNFPMDIQTCTMQLESFGYTMKDLVF 202
           H+VTTDNKLLRI KNG VLYSIRLTL LSC MDLKNFPMD+QTCTMQLESFGYTM DL+F
Sbjct: 143 HDVTTDNKLLRISKNGKVLYSIRLTLTLSCPMDLKNFPMDVQTCTMQLESFGYTMNDLIF 202

Query: 203 EWLEDAPAVQVAEGLTLPQFILRDEKDLGCCTKHYNTGKFTCIEVKFHLERQMGYYLIQM 262
           EWL D P VQVAEGLTLPQFIL++EK+LG CTKHYNTGKFTCIEVKFHLERQMGYYLIQM
Sbjct: 203 EWLSDGP-VQVAEGLTLPQFILKEEKELGYCTKHYNTGKFTCIEVKFHLERQMGYYLIQM 261

Query: 263 YIPSLLIVILSWVSFWINMDAAPARVGLGITTVLTMTTQSSGSRASLPKVSYVKAIDIWM 322
           YIPSLLIVILSWVSFWINMDAAPARV LGITTVLTMTTQSSGSRASLPKVSYVKAIDIWM
Sbjct: 262 YIPSLLIVILSWVSFWINMDAAPARVALGITTVLTMTTQSSGSRASLPKVSYVKAIDIWM 321

Query: 323 AVCLLFVFAALLEYAAINFVSRQHKEFIRLRRRQRRQRLEEDIIQESRFYFRGYGLGHCL 382
           AVCLLFVFAALLEYAA+NFVSRQHKEF+RLRRRQ+RQ  EED+ +ESRF F GYG+GHCL
Sbjct: 322 AVCLLFVFAALLEYAAVNFVSRQHKEFLRLRRRQKRQNKEEDVTRESRFNFSGYGMGHCL 381

Query: 383 QARDGGPMEGSGIYS-PQPPAPLLREGETTRKLYVD 417
           Q +DG  ++ +     PQPP    ++G+  +K +VD
Sbjct: 382 QVKDGTAVKATPANPLPQPP----KDGDAIKKKFVD 413


>gi|4504021 glycine receptor, alpha 2 isoform A [Homo sapiens]
          Length = 452

 Score =  658 bits (1698), Expect = 0.0
 Identities = 324/396 (81%), Positives = 354/396 (89%), Gaps = 7/396 (1%)

Query: 24  RVALAKE-EVKSGTKGSQPMSPSDFLDKLMGRTSGYDARIRPNFKGPPVNVTCNIFINSF 82
           R A  K+ + +SG + SQ +SPSDFLDKLMGRTSGYDARIRPNFKGPPVNVTCNIFINSF
Sbjct: 23  RTAFCKDHDSRSGKQPSQTLSPSDFLDKLMGRTSGYDARIRPNFKGPPVNVTCNIFINSF 82

Query: 83  SSITKTTMDYRVNVFLRQQWNDPRLSYREYPDDSLDLDPSMLDSIWKPDLFFANEKGANF 142
            S+T+TTMDYRVN+FLRQQWND RL+Y EYPDDSLDLDPSMLDSIWKPDLFFANEKGANF
Sbjct: 83  GSVTETTMDYRVNIFLRQQWNDSRLAYSEYPDDSLDLDPSMLDSIWKPDLFFANEKGANF 142

Query: 143 HEVTTDNKLLRIFKNGNVLYSIRLTLILSCLMDLKNFPMDIQTCTMQLESFGYTMKDLVF 202
           H+VTTDNKLLRI KNG VLYSIRLTL LSC MDLKNFPMD+QTCTMQLESFGYTM DL+F
Sbjct: 143 HDVTTDNKLLRISKNGKVLYSIRLTLTLSCPMDLKNFPMDVQTCTMQLESFGYTMNDLIF 202

Query: 203 EWLEDAPAVQVAEGLTLPQFILRDEKDLGCCTKHYNTGKFTCIEVKFHLERQMGYYLIQM 262
           EWL D P VQVAEGLTLPQFIL++EK+LG CTKHYNTGKFTCIEVKFHLERQMGYYLIQM
Sbjct: 203 EWLSDGP-VQVAEGLTLPQFILKEEKELGYCTKHYNTGKFTCIEVKFHLERQMGYYLIQM 261

Query: 263 YIPSLLIVILSWVSFWINMDAAPARVGLGITTVLTMTTQSSGSRASLPKVSYVKAIDIWM 322
           YIPSLLIVILSWVSFWINMDAAPARV LGITTVLTMTTQSSGSRASLPKVSYVKAIDIWM
Sbjct: 262 YIPSLLIVILSWVSFWINMDAAPARVALGITTVLTMTTQSSGSRASLPKVSYVKAIDIWM 321

Query: 323 AVCLLFVFAALLEYAAINFVSRQHKEFIRLRRRQRRQRLEEDIIQESRFYFRGYGLGHCL 382
           AVCLLFVFAALLEYAA+NFVSRQHKEF+RLRRRQ+RQ  EED+ +ESRF F GYG+GHCL
Sbjct: 322 AVCLLFVFAALLEYAAVNFVSRQHKEFLRLRRRQKRQNKEEDVTRESRFNFSGYGMGHCL 381

Query: 383 QARDGGPMEGSGIYS-PQPPAPLLREGETTRKLYVD 417
           Q +DG  ++ +     PQPP    ++G+  +K +VD
Sbjct: 382 QVKDGTAVKATPANPLPQPP----KDGDAIKKKFVD 413


>gi|169646728 glycine receptor, alpha 2 isoform B [Homo sapiens]
          Length = 452

 Score =  657 bits (1694), Expect = 0.0
 Identities = 324/396 (81%), Positives = 353/396 (89%), Gaps = 7/396 (1%)

Query: 24  RVALAKE-EVKSGTKGSQPMSPSDFLDKLMGRTSGYDARIRPNFKGPPVNVTCNIFINSF 82
           R A  K+ + +SG + SQ +SPSDFLDKLMGRTSGYDARIRPNFKGPPVNVTCNIFINSF
Sbjct: 23  RTAFCKDHDSRSGKQPSQTLSPSDFLDKLMGRTSGYDARIRPNFKGPPVNVTCNIFINSF 82

Query: 83  SSITKTTMDYRVNVFLRQQWNDPRLSYREYPDDSLDLDPSMLDSIWKPDLFFANEKGANF 142
            SI +TTMDYRVN+FLRQQWND RL+Y EYPDDSLDLDPSMLDSIWKPDLFFANEKGANF
Sbjct: 83  GSIAETTMDYRVNIFLRQQWNDSRLAYSEYPDDSLDLDPSMLDSIWKPDLFFANEKGANF 142

Query: 143 HEVTTDNKLLRIFKNGNVLYSIRLTLILSCLMDLKNFPMDIQTCTMQLESFGYTMKDLVF 202
           H+VTTDNKLLRI KNG VLYSIRLTL LSC MDLKNFPMD+QTCTMQLESFGYTM DL+F
Sbjct: 143 HDVTTDNKLLRISKNGKVLYSIRLTLTLSCPMDLKNFPMDVQTCTMQLESFGYTMNDLIF 202

Query: 203 EWLEDAPAVQVAEGLTLPQFILRDEKDLGCCTKHYNTGKFTCIEVKFHLERQMGYYLIQM 262
           EWL D P VQVAEGLTLPQFIL++EK+LG CTKHYNTGKFTCIEVKFHLERQMGYYLIQM
Sbjct: 203 EWLSDGP-VQVAEGLTLPQFILKEEKELGYCTKHYNTGKFTCIEVKFHLERQMGYYLIQM 261

Query: 263 YIPSLLIVILSWVSFWINMDAAPARVGLGITTVLTMTTQSSGSRASLPKVSYVKAIDIWM 322
           YIPSLLIVILSWVSFWINMDAAPARV LGITTVLTMTTQSSGSRASLPKVSYVKAIDIWM
Sbjct: 262 YIPSLLIVILSWVSFWINMDAAPARVALGITTVLTMTTQSSGSRASLPKVSYVKAIDIWM 321

Query: 323 AVCLLFVFAALLEYAAINFVSRQHKEFIRLRRRQRRQRLEEDIIQESRFYFRGYGLGHCL 382
           AVCLLFVFAALLEYAA+NFVSRQHKEF+RLRRRQ+RQ  EED+ +ESRF F GYG+GHCL
Sbjct: 322 AVCLLFVFAALLEYAAVNFVSRQHKEFLRLRRRQKRQNKEEDVTRESRFNFSGYGMGHCL 381

Query: 383 QARDGGPMEGSGIYS-PQPPAPLLREGETTRKLYVD 417
           Q +DG  ++ +     PQPP    ++G+  +K +VD
Sbjct: 382 QVKDGTAVKATPANPLPQPP----KDGDAIKKKFVD 413


>gi|110347433 glycine receptor, alpha 3 isoform b [Homo sapiens]
          Length = 449

 Score =  630 bits (1625), Expect = 0.0
 Identities = 312/397 (78%), Positives = 346/397 (87%), Gaps = 10/397 (2%)

Query: 22  LLRVALAKEEVKSGTKGSQPMSPSDFLDKLMGRTSGYDARIRPNFKGPPVNVTCNIFINS 81
           LL   +A +E  S    S PMSPSDFLDKLMGRTSGYDARIRPNFKGPPVNVTCNIFINS
Sbjct: 21  LLLSLVATKETDSARSRSAPMSPSDFLDKLMGRTSGYDARIRPNFKGPPVNVTCNIFINS 80

Query: 82  FSSITKTTMDYRVNVFLRQQWNDPRLSYREYPDDSLDLDPSMLDSIWKPDLFFANEKGAN 141
           F SI +TTMDYRVN+FLRQ+WNDPRL+Y EYPDDSLDLDPSMLDSIWKPDLFFANEKGAN
Sbjct: 81  FGSIAETTMDYRVNIFLRQKWNDPRLAYSEYPDDSLDLDPSMLDSIWKPDLFFANEKGAN 140

Query: 142 FHEVTTDNKLLRIFKNGNVLYSIRLTLILSCLMDLKNFPMDIQTCTMQLESFGYTMKDLV 201
           FHEVTTDNKLLRIFKNGNVLYSIRLTL LSC MDLKNFPMD+QTC MQLESFGYTM DL+
Sbjct: 141 FHEVTTDNKLLRIFKNGNVLYSIRLTLTLSCPMDLKNFPMDVQTCIMQLESFGYTMNDLI 200

Query: 202 FEWLEDAPAVQVAEGLTLPQFILRDEKDLGCCTKHYNTGKFTCIEVKFHLERQMGYYLIQ 261
           FEW ++AP VQVAEGLTLPQF+L++EKDL  CTKHYNTGKFTCIEV+FHLERQMGYYLIQ
Sbjct: 201 FEWQDEAP-VQVAEGLTLPQFLLKEEKDLRYCTKHYNTGKFTCIEVRFHLERQMGYYLIQ 259

Query: 262 MYIPSLLIVILSWVSFWINMDAAPARVGLGITTVLTMTTQSSGSRASLPKVSYVKAIDIW 321
           MYIPSLLIVILSWVSFWINMDAAPARV LGITTVLTMTTQSSGSRASLPKVSYVKAIDIW
Sbjct: 260 MYIPSLLIVILSWVSFWINMDAAPARVALGITTVLTMTTQSSGSRASLPKVSYVKAIDIW 319

Query: 322 MAVCLLFVFAALLEYAAINFVSRQHKEFIRLRRRQRRQRLEEDIIQESRFYFRGYGLGHC 381
           MAVCLLFVF+ALLEYAA+NFVSRQHKE +R RR+++    ++D ++ESRF F  YG+G C
Sbjct: 320 MAVCLLFVFSALLEYAAVNFVSRQHKELLRFRRKRKN---KDDEVRESRFSFTAYGMGPC 376

Query: 382 LQARDGGPMEGSGIYSPQPPAPLL-REGETTRKLYVD 417
           LQA+DG   +G     P  P  ++ +  +  RK+++D
Sbjct: 377 LQAKDGMTPKG-----PNHPVQVMPKSPDEMRKVFID 408


>gi|110347441 glycine receptor, alpha 3 isoform a [Homo sapiens]
          Length = 464

 Score =  625 bits (1613), Expect = e-179
 Identities = 314/409 (76%), Positives = 348/409 (85%), Gaps = 19/409 (4%)

Query: 22  LLRVALAKEEVKSGTKGSQPMSPSDFLDKLMGRTSGYDARIRPNFKGPPVNVTCNIFINS 81
           LL   +A +E  S    S PMSPSDFLDKLMGRTSGYDARIRPNFKGPPVNVTCNIFINS
Sbjct: 21  LLLSLVATKETDSARSRSAPMSPSDFLDKLMGRTSGYDARIRPNFKGPPVNVTCNIFINS 80

Query: 82  FSSITKTTMDYRVNVFLRQQWNDPRLSYREYPDDSLDLDPSMLDSIWKPDLFFANEKGAN 141
           F SI +TTMDYRVN+FLRQ+WNDPRL+Y EYPDDSLDLDPSMLDSIWKPDLFFANEKGAN
Sbjct: 81  FGSIAETTMDYRVNIFLRQKWNDPRLAYSEYPDDSLDLDPSMLDSIWKPDLFFANEKGAN 140

Query: 142 FHEVTTDNKLLRIFKNGNVLYSIRLTLILSCLMDLKNFPMDIQTCTMQLESFGYTMKDLV 201
           FHEVTTDNKLLRIFKNGNVLYSIRLTL LSC MDLKNFPMD+QTC MQLESFGYTM DL+
Sbjct: 141 FHEVTTDNKLLRIFKNGNVLYSIRLTLTLSCPMDLKNFPMDVQTCIMQLESFGYTMNDLI 200

Query: 202 FEWLEDAPAVQVAEGLTLPQFILRDEKDLGCCTKHYNTGKFTCIEVKFHLERQMGYYLIQ 261
           FEW ++AP VQVAEGLTLPQF+L++EKDL  CTKHYNTGKFTCIEV+FHLERQMGYYLIQ
Sbjct: 201 FEWQDEAP-VQVAEGLTLPQFLLKEEKDLRYCTKHYNTGKFTCIEVRFHLERQMGYYLIQ 259

Query: 262 MYIPSLLIVILSWVSFWINMDAAPARVGLGITTVLTMTTQSSGSRASLPKVSYVKAIDIW 321
           MYIPSLLIVILSWVSFWINMDAAPARV LGITTVLTMTTQSSGSRASLPKVSYVKAIDIW
Sbjct: 260 MYIPSLLIVILSWVSFWINMDAAPARVALGITTVLTMTTQSSGSRASLPKVSYVKAIDIW 319

Query: 322 MAVCLLFVFAALLEYAAINFVSRQHKEFIRLRRRQRRQ----RLE--------EDIIQES 369
           MAVCLLFVF+ALLEYAA+NFVSRQHKE +R RR+++ +     LE        +D ++ES
Sbjct: 320 MAVCLLFVFSALLEYAAVNFVSRQHKELLRFRRKRKNKTEAFALEKFYRFSDMDDEVRES 379

Query: 370 RFYFRGYGLGHCLQARDGGPMEGSGIYSPQPPAPLL-REGETTRKLYVD 417
           RF F  YG+G CLQA+DG   +G     P  P  ++ +  +  RK+++D
Sbjct: 380 RFSFTAYGMGPCLQAKDGMTPKG-----PNHPVQVMPKSPDEMRKVFID 423


>gi|119372310 glycine receptor, alpha 1 isoform 2 precursor [Homo
           sapiens]
          Length = 449

 Score =  616 bits (1588), Expect = e-176
 Identities = 307/393 (78%), Positives = 341/393 (86%), Gaps = 9/393 (2%)

Query: 28  AKEEVKSGTKGSQPMSPSDFLDKLMGRTSGYDARIRPNFKGPPVNVTCNIFINSFSSITK 87
           A +E ++     +PMSPSDFLDKLMGRTSGYDARIRPNFKGPPVNV+CNIFINSF SI +
Sbjct: 22  ASKEAEAARSAPKPMSPSDFLDKLMGRTSGYDARIRPNFKGPPVNVSCNIFINSFGSIAE 81

Query: 88  TTMDYRVNVFLRQQWNDPRLSYREYPDDSLDLDPSMLDSIWKPDLFFANEKGANFHEVTT 147
           TTMDYRVN+FLRQQWNDPRL+Y EYPDDSLDLDPSMLDSIWKPDLFFANEKGA+FHE+TT
Sbjct: 82  TTMDYRVNIFLRQQWNDPRLAYNEYPDDSLDLDPSMLDSIWKPDLFFANEKGAHFHEITT 141

Query: 148 DNKLLRIFKNGNVLYSIRLTLILSCLMDLKNFPMDIQTCTMQLESFGYTMKDLVFEWLED 207
           DNKLLRI +NGNVLYSIR+TL L+C MDLKNFPMD+QTC MQLESFGYTM DL+FEW E 
Sbjct: 142 DNKLLRISRNGNVLYSIRITLTLACPMDLKNFPMDVQTCIMQLESFGYTMNDLIFEWQEQ 201

Query: 208 APAVQVAEGLTLPQFILRDEKDLGCCTKHYNTGKFTCIEVKFHLERQMGYYLIQMYIPSL 267
             AVQVA+GLTLPQFIL++EKDL  CTKHYNTGKFTCIE +FHLERQMGYYLIQMYIPSL
Sbjct: 202 G-AVQVADGLTLPQFILKEEKDLRYCTKHYNTGKFTCIEARFHLERQMGYYLIQMYIPSL 260

Query: 268 LIVILSWVSFWINMDAAPARVGLGITTVLTMTTQSSGSRASLPKVSYVKAIDIWMAVCLL 327
           LIVILSW+SFWINMDAAPARVGLGITTVLTMTTQSSGSRASLPKVSYVKAIDIWMAVCLL
Sbjct: 261 LIVILSWISFWINMDAAPARVGLGITTVLTMTTQSSGSRASLPKVSYVKAIDIWMAVCLL 320

Query: 328 FVFAALLEYAAINFVSRQHKEFIRLRRRQRRQRLEEDIIQESRFYFRGYGLG-HCLQARD 386
           FVF+ALLEYAA+NFVSRQHKE +R RR++R  +  ED   E RF F  YG+G  CLQA+D
Sbjct: 321 FVFSALLEYAAVNFVSRQHKELLRFRRKRRHHK--EDEAGEGRFNFSAYGMGPACLQAKD 378

Query: 387 GGPMEG---SGIYSPQPPAPLLREGETTRKLYV 416
           G  ++G   S   +P PPAP  +  E  RKL++
Sbjct: 379 GISVKGANNSNTTNP-PPAP-SKSPEEMRKLFI 409


>gi|225903367 glycine receptor, alpha 1 isoform 1 precursor [Homo
           sapiens]
          Length = 457

 Score =  615 bits (1586), Expect = e-176
 Identities = 307/399 (76%), Positives = 342/399 (85%), Gaps = 13/399 (3%)

Query: 28  AKEEVKSGTKGSQPMSPSDFLDKLMGRTSGYDARIRPNFKGPPVNVTCNIFINSFSSITK 87
           A +E ++     +PMSPSDFLDKLMGRTSGYDARIRPNFKGPPVNV+CNIFINSF SI +
Sbjct: 22  ASKEAEAARSAPKPMSPSDFLDKLMGRTSGYDARIRPNFKGPPVNVSCNIFINSFGSIAE 81

Query: 88  TTMDYRVNVFLRQQWNDPRLSYREYPDDSLDLDPSMLDSIWKPDLFFANEKGANFHEVTT 147
           TTMDYRVN+FLRQQWNDPRL+Y EYPDDSLDLDPSMLDSIWKPDLFFANEKGA+FHE+TT
Sbjct: 82  TTMDYRVNIFLRQQWNDPRLAYNEYPDDSLDLDPSMLDSIWKPDLFFANEKGAHFHEITT 141

Query: 148 DNKLLRIFKNGNVLYSIRLTLILSCLMDLKNFPMDIQTCTMQLESFGYTMKDLVFEWLED 207
           DNKLLRI +NGNVLYSIR+TL L+C MDLKNFPMD+QTC MQLESFGYTM DL+FEW E 
Sbjct: 142 DNKLLRISRNGNVLYSIRITLTLACPMDLKNFPMDVQTCIMQLESFGYTMNDLIFEWQEQ 201

Query: 208 APAVQVAEGLTLPQFILRDEKDLGCCTKHYNTGKFTCIEVKFHLERQMGYYLIQMYIPSL 267
             AVQVA+GLTLPQFIL++EKDL  CTKHYNTGKFTCIE +FHLERQMGYYLIQMYIPSL
Sbjct: 202 G-AVQVADGLTLPQFILKEEKDLRYCTKHYNTGKFTCIEARFHLERQMGYYLIQMYIPSL 260

Query: 268 LIVILSWVSFWINMDAAPARVGLGITTVLTMTTQSSGSRASLPKVSYVKAIDIWMAVCLL 327
           LIVILSW+SFWINMDAAPARVGLGITTVLTMTTQSSGSRASLPKVSYVKAIDIWMAVCLL
Sbjct: 261 LIVILSWISFWINMDAAPARVGLGITTVLTMTTQSSGSRASLPKVSYVKAIDIWMAVCLL 320

Query: 328 FVFAALLEYAAINFVSRQHKEFIRLRRRQRRQR------LEEDIIQESRFYFRGYGLG-H 380
           FVF+ALLEYAA+NFVSRQHKE +R RR++R  +       +ED   E RF F  YG+G  
Sbjct: 321 FVFSALLEYAAVNFVSRQHKELLRFRRKRRHHKSPMLNLFQEDEAGEGRFNFSAYGMGPA 380

Query: 381 CLQARDGGPMEG---SGIYSPQPPAPLLREGETTRKLYV 416
           CLQA+DG  ++G   S   +P PPAP  +  E  RKL++
Sbjct: 381 CLQAKDGISVKGANNSNTTNP-PPAP-SKSPEEMRKLFI 417


>gi|4504023 glycine receptor, beta [Homo sapiens]
          Length = 497

 Score =  335 bits (859), Expect = 5e-92
 Identities = 174/309 (56%), Positives = 226/309 (73%), Gaps = 9/309 (2%)

Query: 43  SPSDFLDKLMGRTSGYDARIRPNFKGPPVNVTCNIFINSFSSITKTTMDYRVNVFLRQQW 102
           S S+ L++L+     YD RIRPNFKG PV+V  NIFINSF SI +TTMDYRVN+FLRQ+W
Sbjct: 55  STSNILNRLL---VSYDPRIRPNFKGIPVDVVVNIFINSFGSIQETTMDYRVNIFLRQKW 111

Query: 103 NDPRLSYRE--YPDDSLDLDPSMLDSIWKPDLFFANEKGANFHEVTTDNKLLRIFKNGNV 160
           NDPRL         D+L +DP+M   +WKPDLFFANEK ANFH+VT +N LL IF++G+V
Sbjct: 112 NDPRLKLPSDFRGSDALTVDPTMYKCLWKPDLFFANEKSANFHDVTQENILLFIFRDGDV 171

Query: 161 LYSIRLTLILSCLMDLKNFPMDIQTCTMQLESFGYTMKDLVFEWLEDAPAVQVAEGLTLP 220
           L S+RL++ LSC +DL  FPMD Q C MQLESFGYT  DL F W    P VQ+ E + LP
Sbjct: 172 LVSMRLSITLSCPLDLTLFPMDTQRCKMQLESFGYTTDDLRFIWQSGDP-VQL-EKIALP 229

Query: 221 QF-ILRDEKDLGCCTKHYN-TGKFTCIEVKFHLERQMGYYLIQMYIPSLLIVILSWVSFW 278
           QF I +++ + G CTK+Y  TG +TC+EV F L RQ+G+Y++ +Y P+LLIV+LSW+SFW
Sbjct: 230 QFDIKKEDIEYGNCTKYYKGTGYYTCVEVIFTLRRQVGFYMMGVYAPTLLIVVLSWLSFW 289

Query: 279 INMDAAPARVGLGITTVLTMTTQSSGSRASLPKVSYVKAIDIWMAVCLLFVFAALLEYAA 338
           IN DA+ ARV LGI +VL++ ++ +   A LPKVSYVKA+D+W+  CLLF FA+L+EYA 
Sbjct: 290 INPDASAARVPLGIFSVLSLASECTTLAAELPKVSYVKALDVWLIACLLFGFASLVEYAV 349

Query: 339 INFVSRQHK 347
           +  +    K
Sbjct: 350 VQVMLNNPK 358


>gi|12548788 gamma-aminobutyric acid (GABA) A receptor, beta 3
           isoform 2 precursor [Homo sapiens]
          Length = 473

 Score =  282 bits (721), Expect = 5e-76
 Identities = 142/317 (44%), Positives = 207/317 (65%), Gaps = 14/317 (4%)

Query: 35  GTKGSQPMSPSD---------FLDKLMGRTSGYDARIRPNFKGPPVNVTCNIFINSFSSI 85
           GT+GS+P S +D          +DKL+    GYD R+RP+F GPPV V  NI I S   +
Sbjct: 19  GTRGSEPRSVNDPGNMSFVKETVDKLL---KGYDIRLRPDFGGPPVCVGMNIDIASIDMV 75

Query: 86  TKTTMDYRVNVFLRQQWNDPRLSYREYPDDSLDLDPSMLDSIWKPDLFFANEKGANFHEV 145
           ++  MDY + ++ +Q W D RL+Y   P + L LD  + D +W PD +F N+K +  H V
Sbjct: 76  SEVNMDYTLTMYFQQYWRDKRLAYSGIPLN-LTLDNRVADQLWVPDTYFLNDKKSFVHGV 134

Query: 146 TTDNKLLRIFKNGNVLYSIRLTLILSCLMDLKNFPMDIQTCTMQLESFGYTMKDLVFEWL 205
           T  N+++R+  +G VLY +R+T   +C+MDL+ +P+D Q CT+++ES+GYT  D+ F W 
Sbjct: 135 TVKNRMIRLHPDGTVLYGLRITTTAACMMDLRRYPLDEQNCTLEIESYGYTTDDIEFYWR 194

Query: 206 EDAPAVQVAEGLTLPQFILRDEKDLGCCTKHYNTGKFTCIEVKFHLERQMGYYLIQMYIP 265
               AV   E + LPQF + + + L      + TG +  + + F L+R +GY+++Q Y+P
Sbjct: 195 GGDKAVTGVERIELPQFSIVEHR-LVSRNVVFATGAYPRLSLSFRLKRNIGYFILQTYMP 253

Query: 266 SLLIVILSWVSFWINMDAAPARVGLGITTVLTMTTQSSGSRASLPKVSYVKAIDIWMAVC 325
           S+LI ILSWVSFWIN DA+ ARV LGITTVLTMTT ++  R +LPK+ YVKAID+++  C
Sbjct: 254 SILITILSWVSFWINYDASAARVALGITTVLTMTTINTHLRETLPKIPYVKAIDMYLMGC 313

Query: 326 LLFVFAALLEYAAINFV 342
            +FVF ALLEYA +N++
Sbjct: 314 FVFVFLALLEYAFVNYI 330


>gi|4503865 gamma-aminobutyric acid (GABA) A receptor, beta 2
           isoform 2 [Homo sapiens]
          Length = 474

 Score =  280 bits (716), Expect = 2e-75
 Identities = 145/331 (43%), Positives = 210/331 (63%), Gaps = 15/331 (4%)

Query: 14  LWTLPGQVLLRVALAKEEVKSGTKGSQPMSPSDFLDKLMGRTSGYDARIRPNFKGPPVNV 73
           +W+ P   L+  A+  + V   +  S      D L K      GYD R+RP+F GPPV V
Sbjct: 12  IWSFP---LIIAAVCAQSVNDPSNMSLVKETVDRLLK------GYDIRLRPDFGGPPVAV 62

Query: 74  TCNIFINSFSSITKTTMDYRVNVFLRQQWNDPRLSYREYPDDSLDLDPSMLDSIWKPDLF 133
             NI I S   +++  MDY + ++ +Q W D RLSY   P + L LD  + D +W PD +
Sbjct: 63  GMNIDIASIDMVSEVNMDYTLTMYFQQAWRDKRLSYNVIPLN-LTLDNRVADQLWVPDTY 121

Query: 134 FANEKGANFHEVTTDNKLLRIFKNGNVLYSIRLTLILSCLMDLKNFPMDIQTCTMQLESF 193
           F N+K +  H VT  N+++R+  +G VLY +R+T   +C+MDL+ +P+D Q CT+++ES+
Sbjct: 122 FLNDKKSFVHGVTVKNRMIRLHPDGTVLYGLRITTTAACMMDLRRYPLDEQNCTLEIESY 181

Query: 194 GYTMKDLVFEWLEDAPAVQVAEGLTLPQFILRDEKDLGCCTKH--YNTGKFTCIEVKFHL 251
           GYT  D+ F W  D  AV     + LPQF + D K +   TK   ++TG +  + + F L
Sbjct: 182 GYTTDDIEFYWRGDDNAVTGVTKIELPQFSIVDYKLI---TKKVVFSTGSYPRLSLSFKL 238

Query: 252 ERQMGYYLIQMYIPSLLIVILSWVSFWINMDAAPARVGLGITTVLTMTTQSSGSRASLPK 311
           +R +GY+++Q Y+PS+LI ILSWVSFWIN DA+ ARV LGITTVLTMTT ++  R +LPK
Sbjct: 239 KRNIGYFILQTYMPSILITILSWVSFWINYDASAARVALGITTVLTMTTINTHLRETLPK 298

Query: 312 VSYVKAIDIWMAVCLLFVFAALLEYAAINFV 342
           + YVKAID+++  C +FVF ALLEYA +N++
Sbjct: 299 IPYVKAIDMYLMGCFVFVFMALLEYALVNYI 329


>gi|12548785 gamma-aminobutyric acid (GABA) A receptor, beta 2
           isoform 1 [Homo sapiens]
          Length = 512

 Score =  280 bits (716), Expect = 2e-75
 Identities = 145/331 (43%), Positives = 210/331 (63%), Gaps = 15/331 (4%)

Query: 14  LWTLPGQVLLRVALAKEEVKSGTKGSQPMSPSDFLDKLMGRTSGYDARIRPNFKGPPVNV 73
           +W+ P   L+  A+  + V   +  S      D L K      GYD R+RP+F GPPV V
Sbjct: 12  IWSFP---LIIAAVCAQSVNDPSNMSLVKETVDRLLK------GYDIRLRPDFGGPPVAV 62

Query: 74  TCNIFINSFSSITKTTMDYRVNVFLRQQWNDPRLSYREYPDDSLDLDPSMLDSIWKPDLF 133
             NI I S   +++  MDY + ++ +Q W D RLSY   P + L LD  + D +W PD +
Sbjct: 63  GMNIDIASIDMVSEVNMDYTLTMYFQQAWRDKRLSYNVIPLN-LTLDNRVADQLWVPDTY 121

Query: 134 FANEKGANFHEVTTDNKLLRIFKNGNVLYSIRLTLILSCLMDLKNFPMDIQTCTMQLESF 193
           F N+K +  H VT  N+++R+  +G VLY +R+T   +C+MDL+ +P+D Q CT+++ES+
Sbjct: 122 FLNDKKSFVHGVTVKNRMIRLHPDGTVLYGLRITTTAACMMDLRRYPLDEQNCTLEIESY 181

Query: 194 GYTMKDLVFEWLEDAPAVQVAEGLTLPQFILRDEKDLGCCTKH--YNTGKFTCIEVKFHL 251
           GYT  D+ F W  D  AV     + LPQF + D K +   TK   ++TG +  + + F L
Sbjct: 182 GYTTDDIEFYWRGDDNAVTGVTKIELPQFSIVDYKLI---TKKVVFSTGSYPRLSLSFKL 238

Query: 252 ERQMGYYLIQMYIPSLLIVILSWVSFWINMDAAPARVGLGITTVLTMTTQSSGSRASLPK 311
           +R +GY+++Q Y+PS+LI ILSWVSFWIN DA+ ARV LGITTVLTMTT ++  R +LPK
Sbjct: 239 KRNIGYFILQTYMPSILITILSWVSFWINYDASAARVALGITTVLTMTTINTHLRETLPK 298

Query: 312 VSYVKAIDIWMAVCLLFVFAALLEYAAINFV 342
           + YVKAID+++  C +FVF ALLEYA +N++
Sbjct: 299 IPYVKAIDMYLMGCFVFVFMALLEYALVNYI 329


>gi|194097327 gamma-aminobutyric acid (GABA) A receptor, beta 1
           precursor [Homo sapiens]
          Length = 474

 Score =  276 bits (706), Expect = 2e-74
 Identities = 135/295 (45%), Positives = 196/295 (66%), Gaps = 5/295 (1%)

Query: 48  LDKLMGRTSGYDARIRPNFKGPPVNVTCNIFINSFSSITKTTMDYRVNVFLRQQWNDPRL 107
           +D+L+    GYD R+RP+F GPPV+V   I + S   +++  MDY + ++ +Q W D RL
Sbjct: 41  VDRLL---KGYDIRLRPDFGGPPVDVGMRIDVASIDMVSEVNMDYTLTMYFQQSWKDKRL 97

Query: 108 SYREYPDDSLDLDPSMLDSIWKPDLFFANEKGANFHEVTTDNKLLRIFKNGNVLYSIRLT 167
           SY   P + L LD  + D +W PD +F N+K +  H VT  N+++R+  +G VLY +R+T
Sbjct: 98  SYSGIPLN-LTLDNRVADQLWVPDTYFLNDKKSFVHGVTVKNRMIRLHPDGTVLYGLRIT 156

Query: 168 LILSCLMDLKNFPMDIQTCTMQLESFGYTMKDLVFEWLEDAPAVQVAEGLTLPQFILRDE 227
              +C+MDL+ +P+D Q CT+++ES+GYT  D+ F W     AV     + LPQF + D 
Sbjct: 157 TTAACMMDLRRYPLDEQNCTLEIESYGYTTDDIEFYWNGGEGAVTGVNKIELPQFSIVDY 216

Query: 228 KDLGCCTKHYNTGKFTCIEVKFHLERQMGYYLIQMYIPSLLIVILSWVSFWINMDAAPAR 287
           K +    + + TG +  + + F L+R +GY+++Q Y+PS LI ILSWVSFWIN DA+ AR
Sbjct: 217 KMVSKKVE-FTTGAYPRLSLSFRLKRNIGYFILQTYMPSTLITILSWVSFWINYDASAAR 275

Query: 288 VGLGITTVLTMTTQSSGSRASLPKVSYVKAIDIWMAVCLLFVFAALLEYAAINFV 342
           V LGITTVLTMTT S+  R +LPK+ YVKAIDI++  C +FVF ALLEYA +N++
Sbjct: 276 VALGITTVLTMTTISTHLRETLPKIPYVKAIDIYLMGCFVFVFLALLEYAFVNYI 330


>gi|4503867 gamma-aminobutyric acid (GABA) A receptor, beta 3
           isoform 1 precursor [Homo sapiens]
          Length = 473

 Score =  275 bits (703), Expect = 6e-74
 Identities = 135/295 (45%), Positives = 197/295 (66%), Gaps = 5/295 (1%)

Query: 48  LDKLMGRTSGYDARIRPNFKGPPVNVTCNIFINSFSSITKTTMDYRVNVFLRQQWNDPRL 107
           +DKL+    GYD R+RP+F GPPV V  NI I S   +++  MDY + ++ +Q W D RL
Sbjct: 41  VDKLL---KGYDIRLRPDFGGPPVCVGMNIDIASIDMVSEVNMDYTLTMYFQQYWRDKRL 97

Query: 108 SYREYPDDSLDLDPSMLDSIWKPDLFFANEKGANFHEVTTDNKLLRIFKNGNVLYSIRLT 167
           +Y   P + L LD  + D +W PD +F N+K +  H VT  N+++R+  +G VLY +R+T
Sbjct: 98  AYSGIPLN-LTLDNRVADQLWVPDTYFLNDKKSFVHGVTVKNRMIRLHPDGTVLYGLRIT 156

Query: 168 LILSCLMDLKNFPMDIQTCTMQLESFGYTMKDLVFEWLEDAPAVQVAEGLTLPQFILRDE 227
              +C+MDL+ +P+D Q CT+++ES+GYT  D+ F W     AV   E + LPQF + + 
Sbjct: 157 TTAACMMDLRRYPLDEQNCTLEIESYGYTTDDIEFYWRGGDKAVTGVERIELPQFSIVEH 216

Query: 228 KDLGCCTKHYNTGKFTCIEVKFHLERQMGYYLIQMYIPSLLIVILSWVSFWINMDAAPAR 287
           + L      + TG +  + + F L+R +GY+++Q Y+PS+LI ILSWVSFWIN DA+ AR
Sbjct: 217 R-LVSRNVVFATGAYPRLSLSFRLKRNIGYFILQTYMPSILITILSWVSFWINYDASAAR 275

Query: 288 VGLGITTVLTMTTQSSGSRASLPKVSYVKAIDIWMAVCLLFVFAALLEYAAINFV 342
           V LGITTVLTMTT ++  R +LPK+ YVKAID+++  C +FVF ALLEYA +N++
Sbjct: 276 VALGITTVLTMTTINTHLRETLPKIPYVKAIDMYLMGCFVFVFLALLEYAFVNYI 330


>gi|34734071 gamma-aminobutyric acid (GABA) A receptor, delta
           precursor [Homo sapiens]
          Length = 452

 Score =  271 bits (693), Expect = 8e-73
 Identities = 136/319 (42%), Positives = 199/319 (62%), Gaps = 2/319 (0%)

Query: 47  FLDKLMGRTSGYDARIRPNFKGPPVNVTCNIFINSFSSITKTTMDYRVNVFLRQQWNDPR 106
           +L  L G  +GY    RP   GPPVNV   + + S   I++  M+Y + VFL Q W D R
Sbjct: 40  WLPNLDGLIAGYARNFRPGIGGPPVNVALALEVASIDHISEANMEYTMTVFLHQSWRDSR 99

Query: 107 LSYREYPDDSLDLDPSMLDSIWKPDLFFANEKGANFHEVTTDNKLLRIFKNGNVLYSIRL 166
           LSY  + +++L LD   +D +W PD F  N K A FH+VT +NKL+R+  +G +LYSIR+
Sbjct: 100 LSYN-HTNETLGLDSRFVDKLWLPDTFIVNAKSAWFHDVTVENKLIRLQPDGVILYSIRI 158

Query: 167 TLILSCLMDLKNFPMDIQTCTMQLESFGYTMKDLVFEWLEDAPAVQVAEGLTLPQFILRD 226
           T  ++C MDL  +PMD Q C + LES+GY+ +D+V+ W E    +   + L L QF +  
Sbjct: 159 TSTVACDMDLAKYPMDEQECMLDLESYGYSSEDIVYYWSESQEHIHGLDKLQLAQFTITS 218

Query: 227 EKDLGCCTKHYNTGKFTCIEVKFHLERQMGYYLIQMYIPSLLIVILSWVSFWINMDAAPA 286
            +         + G+F  + + FHL R  G Y+IQ Y+PS+L+V +SWVSFWI+  A PA
Sbjct: 219 YRFTTELMNFKSAGQFPRLSLHFHLRRNRGVYIIQSYMPSVLLVAMSWVSFWISQAAVPA 278

Query: 287 RVGLGITTVLTMTTQSSGSRASLPKVSYVKAIDIWMAVCLLFVFAALLEYAAINFVSRQH 346
           RV LGITTVLTMTT    +R+SLP+ S +KA+D++  +C +FVFAAL+EYA  +F +  +
Sbjct: 279 RVSLGITTVLTMTTLMVSARSSLPRASAIKALDVYFWICYVFVFAALVEYAFAHF-NADY 337

Query: 347 KEFIRLRRRQRRQRLEEDI 365
           ++  + + +  R R E D+
Sbjct: 338 RKKQKAKVKVSRPRAEMDV 356


>gi|7657106 gamma-aminobutyric acid (GABA) A receptor, pi [Homo
           sapiens]
          Length = 440

 Score =  260 bits (665), Expect = 1e-69
 Identities = 127/293 (43%), Positives = 191/293 (65%), Gaps = 6/293 (2%)

Query: 55  TSGYDARIRPNFKGPPVNVTCNIFINSFSSITKTTMDYRVNVFLRQQWNDPRLSYREYPD 114
           T+GY+  +RPNF G PV +   + I S SSI+++ MDY   ++LRQ+W D RL +    +
Sbjct: 45  TAGYNKFLRPNFGGEPVQIALTLDIASISSISESNMDYTATIYLRQRWMDQRLVFEG--N 102

Query: 115 DSLDLDPSMLDSIWKPDLFFANEKGANFHEVTTDNKLLRIFKNGNVLYSIRLTLILSCLM 174
            S  LD  +++ +W PD +    K +  HEVT  N+L+R+F NG VLY++R+T  ++C M
Sbjct: 103 KSFTLDARLVEFLWVPDTYIVESKKSFLHEVTVGNRLIRLFSNGTVLYALRITTTVACNM 162

Query: 175 DLKNFPMDIQTCTMQLESFGYTMKDLVFEWLEDAPAVQVAEGLTLPQFILRDEKDLGCCT 234
           DL  +PMD QTC +QLES+GY   D+ F WL    +V+  E L L Q+ +  E+     T
Sbjct: 163 DLSKYPMDTQTCKLQLESWGYDGNDVEFTWLRGNDSVRGLEHLRLAQYTI--ERYFTLVT 220

Query: 235 K-HYNTGKFTCIEVKFHLERQMGYYLIQMYIPSLLIVILSWVSFWINMDAAPARVGLGIT 293
           +    TG +T + ++F L R + Y++++ Y+PS  +V+LSWVSFWI++D+ PAR  +G+T
Sbjct: 221 RSQQETGNYTRLVLQFELRRNVLYFILETYVPSTFLVVLSWVSFWISLDSVPARTCIGVT 280

Query: 294 TVLTMTTQSSGSRASLPKVS-YVKAIDIWMAVCLLFVFAALLEYAAINFVSRQ 345
           TVL+MTT   GSR SLP  + ++KAID+++ +C  FVF ALLEYA  ++ S Q
Sbjct: 281 TVLSMTTLMIGSRTSLPNTNCFIKAIDVYLGICFSFVFGALLEYAVAHYSSLQ 333


>gi|153266866 gamma-aminobutyric acid (GABA) receptor, rho 2
           precursor [Homo sapiens]
          Length = 490

 Score =  258 bits (660), Expect = 5e-69
 Identities = 124/303 (40%), Positives = 199/303 (65%), Gaps = 1/303 (0%)

Query: 54  RTSGYDARIRPNFKGPPVNVTCNIFINSFSSITKTTMDYRVNVFLRQQWNDPRLSYREYP 113
           R   +D  +RP F GP + V  ++ + S  SI++  MD+ + ++LR  W D RL++    
Sbjct: 85  RVDEHDFSMRPAFGGPAIPVGVDVQVESLDSISEVDMDFTMTLYLRHYWKDERLAFSSAS 144

Query: 114 DDSLDLDPSMLDSIWKPDLFFANEKGANFHEVTTDNKLLRIFKNGNVLYSIRLTLILSCL 173
           + S+  D  ++  IW PD+FF + K +  H+ TTDN +LR+F +G+VLYS+R+T+   C 
Sbjct: 145 NKSMTFDGRLVKKIWVPDVFFVHSKRSFTHDTTTDNIMLRVFPDGHVLYSMRITVTAMCN 204

Query: 174 MDLKNFPMDIQTCTMQLESFGYTMKDLVFEWLEDAPAVQVAEGLTLPQFILRDEKDLGCC 233
           MD  +FP+D QTC+++LES+ YT +DL+  W     +++  E ++L QF+++        
Sbjct: 205 MDFSHFPLDSQTCSLELESYAYTDEDLMLYWKNGDESLKTDEKISLSQFLIQKFHTTSRL 264

Query: 234 TKHYNTGKFTCIEVKFHLERQMGYYLIQMYIPSLLIVILSWVSFWINMDAAPARVGLGIT 293
             + +TG +  + + F L R + ++L+Q Y P+ L+V+LSWVSFWI+  A PARV LGIT
Sbjct: 265 AFYSSTGWYNRLYINFTLRRHIFFFLLQTYFPATLMVMLSWVSFWIDRRAVPARVSLGIT 324

Query: 294 TVLTMTTQSSGSRASLPKVSYVKAIDIWMAVCLLFVFAALLEYAAINFVSR-QHKEFIRL 352
           TVLTMTT  +G  AS+P+VSYVKA+DI++ V  +FVF ++LEYAA+N+++  Q ++  +L
Sbjct: 325 TVLTMTTIITGVNASMPRVSYVKAVDIYLWVSFVFVFLSVLEYAAVNYLTTVQERKERKL 384

Query: 353 RRR 355
           R +
Sbjct: 385 REK 387


>gi|8924258 gamma-aminobutyric acid (GABA) receptor, theta precursor
           [Homo sapiens]
          Length = 632

 Score =  255 bits (651), Expect = 6e-68
 Identities = 129/313 (41%), Positives = 196/313 (62%), Gaps = 7/313 (2%)

Query: 48  LDKLMGRTSGYDARIRPNFKGPPVNVTCNIFINSFSSITKTTMDYRVNVFLRQQWNDPRL 107
           LD+++ R   YD R+RPNF G PV V  +I++ S   I++  MDY + +F  Q W D RL
Sbjct: 63  LDRVLSR---YDVRLRPNFGGAPVPVRISIYVTSIEQISEMNMDYTITMFFHQTWKDSRL 119

Query: 108 SYREYPDDSLDLDPSMLDSIWKPDLFFANEKGANFHEVTTDNKLLRIFKNGNVLYSIRLT 167
           +Y E    +L LD  M + +W PD +F N K A  H+VT +N++ ++  +G V Y IRLT
Sbjct: 120 AYYE-TTLNLTLDYRMHEKLWVPDCYFLNSKDAFVHDVTVENRVFQLHPDGTVRYGIRLT 178

Query: 168 LILSCLMDLKNFPMDIQTCTMQLESFGYTMKDLVFEWLEDAPAVQVAEGLTLPQFILRDE 227
              +C +DL  FPMD Q C + +ES+GYT++D++  W ++  A+ + E L +PQF     
Sbjct: 179 TTAACSLDLHKFPMDKQACNLVVESYGYTVEDIILFWDDNGNAIHMTEELHIPQFTFLG- 237

Query: 228 KDLGCCTKHYNTGKFTCIEVKFHLERQMGYYLIQMYIPSLLIVILSWVSFWINMDAAPAR 287
           + +     ++ TG +  + +KF ++R++  YL+Q+Y P++L  I SW+SFW+N D++ AR
Sbjct: 238 RTITSKEVYFYTGSYIRLILKFQVQREVNSYLVQVYWPTVLTTITSWISFWMNYDSSAAR 297

Query: 288 VGLGITTVLTMTTQSSGSRASLPKVSYVKAIDIWMAVCLLFVFAALLEYAAIN--FVSRQ 345
           V +G+T++L +TT  S  R  LP +S +KAIDI++ VCL FVF +LLEY  IN  F SR 
Sbjct: 298 VTIGLTSMLILTTIDSHLRDKLPNISCIKAIDIYILVCLFFVFLSLLEYVYINYLFYSRG 357

Query: 346 HKEFIRLRRRQRR 358
            +   R  RR RR
Sbjct: 358 PRRQPRRHRRPRR 370


>gi|194097386 gamma-aminobutyric acid (GABA) receptor, rho 1 [Homo
           sapiens]
          Length = 479

 Score =  253 bits (646), Expect = 2e-67
 Identities = 121/303 (39%), Positives = 197/303 (65%), Gaps = 1/303 (0%)

Query: 54  RTSGYDARIRPNFKGPPVNVTCNIFINSFSSITKTTMDYRVNVFLRQQWNDPRLSYREYP 113
           R   +D  +RP F GP + V  ++ + S  SI++  MD+ + ++LR  W D RLS+    
Sbjct: 80  RIDDHDFSMRPGFGGPAIPVGVDVQVESLDSISEVDMDFTMTLYLRHYWKDERLSFPSTN 139

Query: 114 DDSLDLDPSMLDSIWKPDLFFANEKGANFHEVTTDNKLLRIFKNGNVLYSIRLTLILSCL 173
           + S+  D  ++  IW PD+FF + K +  H+ TTDN +LR+  +G VLYS+R+T+   C 
Sbjct: 140 NLSMTFDGRLVKKIWVPDMFFVHSKRSFIHDTTTDNVMLRVQPDGKVLYSLRVTVTAMCN 199

Query: 174 MDLKNFPMDIQTCTMQLESFGYTMKDLVFEWLEDAPAVQVAEGLTLPQFILRDEKDLGCC 233
           MD   FP+D QTC++++ES+ YT  DL+  W +   +++  E ++L QF++++       
Sbjct: 200 MDFSRFPLDTQTCSLEIESYAYTEDDLMLYWKKGNDSLKTDERISLSQFLIQEFHTTTKL 259

Query: 234 TKHYNTGKFTCIEVKFHLERQMGYYLIQMYIPSLLIVILSWVSFWINMDAAPARVGLGIT 293
             + +TG +  + + F L R + ++L+Q Y P+ L+V+LSWVSFWI+  A PARV LGIT
Sbjct: 260 AFYSSTGWYNRLYINFTLRRHIFFFLLQTYFPATLMVMLSWVSFWIDRRAVPARVPLGIT 319

Query: 294 TVLTMTTQSSGSRASLPKVSYVKAIDIWMAVCLLFVFAALLEYAAINFVSR-QHKEFIRL 352
           TVLTM+T  +G  AS+P+VSY+KA+DI++ V  +FVF ++LEYAA+N+++  Q ++  +L
Sbjct: 320 TVLTMSTIITGVNASMPRVSYIKAVDIYLWVSFVFVFLSVLEYAAVNYLTTVQERKEQKL 379

Query: 353 RRR 355
           R +
Sbjct: 380 REK 382


>gi|157389018 gamma-aminobutyric acid A receptor, alpha 6 precursor
           [Homo sapiens]
          Length = 453

 Score =  251 bits (641), Expect = 9e-67
 Identities = 141/333 (42%), Positives = 199/333 (59%), Gaps = 19/333 (5%)

Query: 12  LLLWTLPGQVLLRVALAKEEVKSGTKGSQPMSPSDFLDKLMGRTSGYDARIRPNFKGPPV 71
           ++LW       L  AL K EV+         + S  LD L+    GYD R+RP F G   
Sbjct: 10  IILW-------LENALGKLEVEGNFYSE---NVSRILDNLL---EGYDNRLRPGFGGAVT 56

Query: 72  NVTCNIFINSFSSITKTTMDYRVNVFLRQQWNDPRLSYREYPDDSLDLDPSMLDSIWKPD 131
            V  +I++ SF  ++   M+Y ++VF RQ W D RL +   P + L L+  M+  IW PD
Sbjct: 57  EVKTDIYVTSFGPVSDVEMEYTMDVFFRQTWTDERLKFGG-PTEILSLNNLMVSKIWTPD 115

Query: 132 LFFANEKGANFHEVTTDNKLLRIFKNGNVLYSIRLTLILSCLMDLKNFPMDIQTCTMQLE 191
            FF N K +  H +TT NKL RI +NG +LY++RLT+   C M L NFPMD   C ++  
Sbjct: 116 TFFRNGKKSIAHNMTTPNKLFRIMQNGTILYTMRLTINADCPMRLVNFPMDGHACPLKFG 175

Query: 192 SFGYTMKDLVFEWLEDAPAVQVA---EGLTLPQFILRDEKDLGCCTKHYNTGKFTCIEVK 248
           S+ Y   ++++ W +  P   V    E  +L Q+ L  +  +   T   NTG++  + V 
Sbjct: 176 SYAYPKSEIIYTW-KKGPLYSVEVPEESSSLLQYDLIGQT-VSSETIKSNTGEYVIMTVY 233

Query: 249 FHLERQMGYYLIQMYIPSLLIVILSWVSFWINMDAAPARVGLGITTVLTMTTQSSGSRAS 308
           FHL+R+MGY++IQ+Y P ++ VILS VSFWIN ++ PAR   GITTVLTMTT S  +R S
Sbjct: 234 FHLQRKMGYFMIQIYTPCIMTVILSQVSFWINKESVPARTVFGITTVLTMTTLSISARHS 293

Query: 309 LPKVSYVKAIDIWMAVCLLFVFAALLEYAAINF 341
           LPKVSY  A+D ++AVC  FVF+AL+E+AA+N+
Sbjct: 294 LPKVSYATAMDWFIAVCFAFVFSALIEFAAVNY 326


>gi|38788135 gamma-aminobutyric acid A receptor, gamma 2 isoform 2
           precursor [Homo sapiens]
          Length = 467

 Score =  248 bits (633), Expect = 7e-66
 Identities = 125/294 (42%), Positives = 184/294 (62%), Gaps = 8/294 (2%)

Query: 57  GYDARIRPNFKGPPVNVTCNIFINSFSSITKTTMDYRVNVFLRQQWNDPRLSYREYPDDS 116
           GYD ++RP+    P  +  ++++NS   +    M+Y +++F  Q W D RL +       
Sbjct: 76  GYDNKLRPDIGVKPTLIHTDMYVNSIGPVNAINMEYTIDIFFAQTWYDRRLKFNS-TIKV 134

Query: 117 LDLDPSMLDSIWKPDLFFANEKGANFHEVTTDNKLLRIFKNGNVLYSIRLTLILSCLMDL 176
           L L+ +M+  IW PD FF N K A+ H +TT N++LRI+ +G VLY++RLT+   C + L
Sbjct: 135 LRLNSNMVGKIWIPDTFFRNSKKADAHWITTPNRMLRIWNDGRVLYTLRLTIDAECQLQL 194

Query: 177 KNFPMDIQTCTMQLESFGYTMKDLVFEWLEDAPAVQVAEGLTLPQFI---LRDEKDLGCC 233
            NFPMD  +C ++  S+GY  +++V++W   +  V       L QF    LR+  ++   
Sbjct: 195 HNFPMDEHSCPLEFSSYGYPREEIVYQWKRSSVEVGDTRSWRLYQFSFVGLRNTTEVVKT 254

Query: 234 TKHYNTGKFTCIEVKFHLERQMGYYLIQMYIPSLLIVILSWVSFWINMDAAPARVGLGIT 293
           T    +G +  + V F L R+MGY+ IQ YIP  LIV+LSWVSFWIN DA PAR  LGIT
Sbjct: 255 T----SGDYVVMSVYFDLSRRMGYFTIQTYIPCTLIVVLSWVSFWINKDAVPARTSLGIT 310

Query: 294 TVLTMTTQSSGSRASLPKVSYVKAIDIWMAVCLLFVFAALLEYAAINFVSRQHK 347
           TVLTMTT S+ +R SLPKVSYV A+D++++VC +FVF+AL+EY  +++     K
Sbjct: 311 TVLTMTTLSTIARKSLPKVSYVTAMDLFVSVCFIFVFSALVEYGTLHYFVSNRK 364


>gi|38788155 gamma-aminobutyric acid A receptor, gamma 2 isoform 1
           precursor [Homo sapiens]
          Length = 475

 Score =  248 bits (633), Expect = 7e-66
 Identities = 125/294 (42%), Positives = 184/294 (62%), Gaps = 8/294 (2%)

Query: 57  GYDARIRPNFKGPPVNVTCNIFINSFSSITKTTMDYRVNVFLRQQWNDPRLSYREYPDDS 116
           GYD ++RP+    P  +  ++++NS   +    M+Y +++F  Q W D RL +       
Sbjct: 76  GYDNKLRPDIGVKPTLIHTDMYVNSIGPVNAINMEYTIDIFFAQTWYDRRLKFNS-TIKV 134

Query: 117 LDLDPSMLDSIWKPDLFFANEKGANFHEVTTDNKLLRIFKNGNVLYSIRLTLILSCLMDL 176
           L L+ +M+  IW PD FF N K A+ H +TT N++LRI+ +G VLY++RLT+   C + L
Sbjct: 135 LRLNSNMVGKIWIPDTFFRNSKKADAHWITTPNRMLRIWNDGRVLYTLRLTIDAECQLQL 194

Query: 177 KNFPMDIQTCTMQLESFGYTMKDLVFEWLEDAPAVQVAEGLTLPQFI---LRDEKDLGCC 233
            NFPMD  +C ++  S+GY  +++V++W   +  V       L QF    LR+  ++   
Sbjct: 195 HNFPMDEHSCPLEFSSYGYPREEIVYQWKRSSVEVGDTRSWRLYQFSFVGLRNTTEVVKT 254

Query: 234 TKHYNTGKFTCIEVKFHLERQMGYYLIQMYIPSLLIVILSWVSFWINMDAAPARVGLGIT 293
           T    +G +  + V F L R+MGY+ IQ YIP  LIV+LSWVSFWIN DA PAR  LGIT
Sbjct: 255 T----SGDYVVMSVYFDLSRRMGYFTIQTYIPCTLIVVLSWVSFWINKDAVPARTSLGIT 310

Query: 294 TVLTMTTQSSGSRASLPKVSYVKAIDIWMAVCLLFVFAALLEYAAINFVSRQHK 347
           TVLTMTT S+ +R SLPKVSYV A+D++++VC +FVF+AL+EY  +++     K
Sbjct: 311 TVLTMTTLSTIARKSLPKVSYVTAMDLFVSVCFIFVFSALVEYGTLHYFVSNRK 364


>gi|34452723 gamma-aminobutyric acid A receptor, alpha 4 precursor
           [Homo sapiens]
          Length = 554

 Score =  248 bits (633), Expect = 7e-66
 Identities = 136/350 (38%), Positives = 203/350 (58%), Gaps = 4/350 (1%)

Query: 23  LRVALAKEEVKSGTKGSQPMSPSDFLDKLMGRTSGYDARIRPNFKGPPVNVTCNIFINSF 82
           L +A+   E     +  + +   +F   L     GYD R+RP F GP   V  +I++ SF
Sbjct: 24  LCLAVCLNESPGQNQKEEKLCTENFTRILDSLLDGYDNRLRPGFGGPVTEVKTDIYVTSF 83

Query: 83  SSITKTTMDYRVNVFLRQQWNDPRLSYREYPDDSLDLDPSMLDSIWKPDLFFANEKGANF 142
             ++   M+Y ++VF RQ W D RL Y + P + L L+  M+  +W PD FF N K +  
Sbjct: 84  GPVSDVEMEYTMDVFFRQTWIDKRLKY-DGPIEILRLNNMMVTKVWTPDTFFRNGKKSVS 142

Query: 143 HEVTTDNKLLRIFKNGNVLYSIRLTLILSCLMDLKNFPMDIQTCTMQLESFGYTMKDLVF 202
           H +T  NKL RI +NG +LY++RLT+   C M L +FPMD   C ++  S+ Y   ++++
Sbjct: 143 HNMTAPNKLFRIMRNGTILYTMRLTISAECPMRLVDFPMDGHACPLKFGSYAYPKSEMIY 202

Query: 203 EWLEDAP-AVQVA-EGLTLPQFILRDEKDLGCCTKHYNTGKFTCIEVKFHLERQMGYYLI 260
            W +    +V+V  E  +L Q+ L  +       K   TG++  + V FHL R+MGY++I
Sbjct: 203 TWTKGPEKSVEVPKESSSLVQYDLIGQTVSSETIKSI-TGEYIVMTVYFHLRRKMGYFMI 261

Query: 261 QMYIPSLLIVILSWVSFWINMDAAPARVGLGITTVLTMTTQSSGSRASLPKVSYVKAIDI 320
           Q YIP ++ VILS VSFWIN ++ PAR   GITTVLTMTT S  +R SLPKVSY  A+D 
Sbjct: 262 QTYIPCIMTVILSQVSFWINKESVPARTVFGITTVLTMTTLSISARHSLPKVSYATAMDW 321

Query: 321 WMAVCLLFVFAALLEYAAINFVSRQHKEFIRLRRRQRRQRLEEDIIQESR 370
           ++AVC  FVF+AL+E+AA+N+ +    E  + +  +  Q +    +Q  +
Sbjct: 322 FIAVCFAFVFSALIEFAAVNYFTNIQMEKAKRKTSKPPQEVPAAPVQREK 371


>gi|167000817 gamma-aminobutyric acid A receptor, alpha 2 [Homo
           sapiens]
          Length = 451

 Score =  246 bits (627), Expect = 4e-65
 Identities = 129/300 (43%), Positives = 195/300 (65%), Gaps = 7/300 (2%)

Query: 48  LDKLMGRTSGYDARIRPNFKGPPVNVTCNIFINSFSSITKTTMDYRVNVFLRQQWNDPRL 107
           LD+L+    GYD R+RP        V  NI++ SF  ++ T M+Y ++VF RQ+W D RL
Sbjct: 46  LDRLL---DGYDNRLRPGLGDSITEVFTNIYVTSFGPVSDTDMEYTIDVFFRQKWKDERL 102

Query: 108 SYREYPDDSLDLDPSMLDSIWKPDLFFANEKGANFHEVTTDNKLLRIFKNGNVLYSIRLT 167
            ++  P + L L+  M   IW PD FF N K +  H +T  NKLLRI  +G +LY++RLT
Sbjct: 103 KFKG-PMNILRLNNLMASKIWTPDTFFHNGKKSVAHNMTMPNKLLRIQDDGTLLYTMRLT 161

Query: 168 LILSCLMDLKNFPMDIQTCTMQLESFGYTMKDLVFEWLEDAP-AVQVA-EGLTLPQFILR 225
           +   C M L++FPMD  +C ++  S+ YT  ++ + W  +A  +VQVA +G  L Q+ L 
Sbjct: 162 VQAECPMHLEDFPMDAHSCPLKFGSYAYTTSEVTYIWTYNASDSVQVAPDGSRLNQYDLL 221

Query: 226 DEKDLGCCTKHYNTGKFTCIEVKFHLERQMGYYLIQMYIPSLLIVILSWVSFWINMDAAP 285
            +  +G  T   +TG++T +   FHL+R++GY++IQ Y+P ++ VILS VSFW+N ++ P
Sbjct: 222 GQS-IGKETIKSSTGEYTVMTAHFHLKRKIGYFVIQTYLPCIMTVILSQVSFWLNRESVP 280

Query: 286 ARVGLGITTVLTMTTQSSGSRASLPKVSYVKAIDIWMAVCLLFVFAALLEYAAINFVSRQ 345
           AR   G+TTVLTMTT S  +R SLPKV+Y  A+D ++AVC  FVF+AL+E+A +N+ +++
Sbjct: 281 ARTVFGVTTVLTMTTLSISARNSLPKVAYATAMDWFIAVCYAFVFSALIEFATVNYFTKR 340


>gi|167000751 gamma-aminobutyric acid A receptor, alpha 2 precursor
           [Homo sapiens]
          Length = 451

 Score =  246 bits (627), Expect = 4e-65
 Identities = 129/300 (43%), Positives = 195/300 (65%), Gaps = 7/300 (2%)

Query: 48  LDKLMGRTSGYDARIRPNFKGPPVNVTCNIFINSFSSITKTTMDYRVNVFLRQQWNDPRL 107
           LD+L+    GYD R+RP        V  NI++ SF  ++ T M+Y ++VF RQ+W D RL
Sbjct: 46  LDRLL---DGYDNRLRPGLGDSITEVFTNIYVTSFGPVSDTDMEYTIDVFFRQKWKDERL 102

Query: 108 SYREYPDDSLDLDPSMLDSIWKPDLFFANEKGANFHEVTTDNKLLRIFKNGNVLYSIRLT 167
            ++  P + L L+  M   IW PD FF N K +  H +T  NKLLRI  +G +LY++RLT
Sbjct: 103 KFKG-PMNILRLNNLMASKIWTPDTFFHNGKKSVAHNMTMPNKLLRIQDDGTLLYTMRLT 161

Query: 168 LILSCLMDLKNFPMDIQTCTMQLESFGYTMKDLVFEWLEDAP-AVQVA-EGLTLPQFILR 225
           +   C M L++FPMD  +C ++  S+ YT  ++ + W  +A  +VQVA +G  L Q+ L 
Sbjct: 162 VQAECPMHLEDFPMDAHSCPLKFGSYAYTTSEVTYIWTYNASDSVQVAPDGSRLNQYDLL 221

Query: 226 DEKDLGCCTKHYNTGKFTCIEVKFHLERQMGYYLIQMYIPSLLIVILSWVSFWINMDAAP 285
            +  +G  T   +TG++T +   FHL+R++GY++IQ Y+P ++ VILS VSFW+N ++ P
Sbjct: 222 GQS-IGKETIKSSTGEYTVMTAHFHLKRKIGYFVIQTYLPCIMTVILSQVSFWLNRESVP 280

Query: 286 ARVGLGITTVLTMTTQSSGSRASLPKVSYVKAIDIWMAVCLLFVFAALLEYAAINFVSRQ 345
           AR   G+TTVLTMTT S  +R SLPKV+Y  A+D ++AVC  FVF+AL+E+A +N+ +++
Sbjct: 281 ARTVFGVTTVLTMTTLSISARNSLPKVAYATAMDWFIAVCYAFVFSALIEFATVNYFTKR 340


>gi|110347416 gamma-aminobutyric acid (GABA) A receptor, gamma 3
           [Homo sapiens]
          Length = 467

 Score =  246 bits (627), Expect = 4e-65
 Identities = 129/311 (41%), Positives = 189/311 (60%), Gaps = 9/311 (2%)

Query: 39  SQPMSPSDFLDKLMGRTSGYDARIRPNFKGPPVNVTCNIFINSFSSITKTTMDYRVNVFL 98
           SQ    +  L+KL+     YD ++RP+    P  +  +I++NS   ++   M+Y++++F 
Sbjct: 42  SQDTDVTLILNKLLRE---YDKKLRPDIGIKPTVIDVDIYVNSIGPVSSINMEYQIDIFF 98

Query: 99  RQQWNDPRLSYREYPDDSLDLDPSMLDSIWKPDLFFANEKGANFHEVTTDNKLLRIFKNG 158
            Q W D RL +       L L+ +M+  IW PD  F N K A  H +TT N+LLRI+ +G
Sbjct: 99  AQTWTDSRLRFNSTMK-ILTLNSNMVGLIWIPDTIFRNSKTAEAHWITTPNQLLRIWNDG 157

Query: 159 NVLYSIRLTLILSCLMDLKNFPMDIQTCTMQLESFGYTMKDLVFEWLEDAPAVQVAEGLT 218
            +LY++RLT+   C + L NFPMD  +C +   S+GY  +++++ W +++      +   
Sbjct: 158 KILYTLRLTINAECQLQLHNFPMDEHSCPLIFSSYGYPKEEMIYRWRKNSVEAADQKSWR 217

Query: 219 LPQFILRDEKDLGCCTKHYNT--GKFTCIEVKFHLERQMGYYLIQMYIPSLLIVILSWVS 276
           L QF   D   L   T+   T  G +  + + F L R+MGY+ IQ YIP +L V+LSWVS
Sbjct: 218 LYQF---DFMGLRNTTEIVTTSAGDYVVMTIYFELSRRMGYFTIQTYIPCILTVVLSWVS 274

Query: 277 FWINMDAAPARVGLGITTVLTMTTQSSGSRASLPKVSYVKAIDIWMAVCLLFVFAALLEY 336
           FWI  DA PAR  LGITTVLTMTT S+ +R SLP+VSYV A+D+++ VC LFVFAAL+EY
Sbjct: 275 FWIKKDATPARTALGITTVLTMTTLSTIARKSLPRVSYVTAMDLFVTVCFLFVFAALMEY 334

Query: 337 AAINFVSRQHK 347
           A +N+ S   K
Sbjct: 335 ATLNYYSSCRK 345


>gi|31742490 gamma-aminobutyric acid A receptor, gamma 1 precursor
           [Homo sapiens]
          Length = 465

 Score =  245 bits (626), Expect = 5e-65
 Identities = 126/307 (41%), Positives = 190/307 (61%), Gaps = 12/307 (3%)

Query: 46  DFLDKLMGRTSGYDARIRPNFKGPPVNVTCNIFINSFSSITKTTMDYRVNVFLRQQWNDP 105
           D    L     GYD ++RP+    P  +  ++++NS   +    M+Y +++   Q W D 
Sbjct: 63  DITQILNSLLQGYDNKLRPDIGVRPTVIETDVYVNSIGPVDPINMEYTIDIIFAQTWFDS 122

Query: 106 RLSYREYPDDSLDLDPSMLDSIWKPDLFFANEKGANFHEVTTDNKLLRIFKNGNVLYSIR 165
           RL +       L L+ +M+  IW PD FF N + ++ H +TT N+LLRI+ +G VLY++R
Sbjct: 123 RLKFNSTMK-VLMLNSNMVGKIWIPDTFFRNSRKSDAHWITTPNRLLRIWNDGRVLYTLR 181

Query: 166 LTLILSCLMDLKNFPMDIQTCTMQLESFGYTMKDLVFEWLEDAPAVQVAEGL--TLPQFI 223
           LT+   C + L NFPMD  +C ++  S+GY   ++ ++W +  P+V+VA+     L QF 
Sbjct: 182 LTINAECYLQLHNFPMDEHSCPLEFSSYGYPKNEIEYKWKK--PSVEVADPKYWRLYQFA 239

Query: 224 ---LRDEKDLGCCTKHYNTGKFTCIEVKFHLERQMGYYLIQMYIPSLLIVILSWVSFWIN 280
              LR+  ++     H  +G +  + + F L R+MGY+ IQ YIP +L V+LSWVSFWIN
Sbjct: 240 FVGLRNSTEI----THTISGDYVIMTIFFDLSRRMGYFTIQTYIPCILTVVLSWVSFWIN 295

Query: 281 MDAAPARVGLGITTVLTMTTQSSGSRASLPKVSYVKAIDIWMAVCLLFVFAALLEYAAIN 340
            DA PAR  LGITTVLTMTT S+ +R SLPKVSYV A+D++++VC +FVFAAL+EY  ++
Sbjct: 296 KDAVPARTSLGITTVLTMTTLSTIARKSLPKVSYVTAMDLFVSVCFIFVFAALMEYGTLH 355

Query: 341 FVSRQHK 347
           + +   K
Sbjct: 356 YFTSNQK 362


>gi|157743288 gamma-aminobutyric acid (GABA) receptor, rho 3 [Homo
           sapiens]
          Length = 467

 Score =  245 bits (625), Expect = 6e-65
 Identities = 120/315 (38%), Positives = 192/315 (60%), Gaps = 4/315 (1%)

Query: 59  DARIRPNFKGPPVNVTCNIFINSFSSITKTTMDYRVNVFLRQQWNDPRLSYREYPDDSLD 118
           D  +RP F G PV V  ++ + S  SI++T MD+ +  +LR  W D RLS+    + S+ 
Sbjct: 71  DFAMRPGFGGSPVPVGIDVHVESIDSISETNMDFTMTFYLRHYWKDERLSFPSTANKSMT 130

Query: 119 LDPSMLDSIWKPDLFFANEKGANFHEVTTDNKLLRIFKNGNVLYSIRLTLILSCLMDLKN 178
            D  +   IW PD+FF + K +  H+ T +N +LR+  +GNVL S+R+T+   C MD   
Sbjct: 131 FDHRLTRKIWVPDIFFVHSKRSFIHDTTMENIMLRVHPDGNVLLSLRITVSAMCFMDFSR 190

Query: 179 FPMDIQTCTMQLESFGYTMKDLVFEWLEDAPAVQVAEGLTLPQFILRDEKDLGCCTKHYN 238
           FP+D Q C+++LES+ Y   DL+  W     ++   E ++L QF + D         + +
Sbjct: 191 FPLDTQNCSLELESYAYNEDDLMLYWKHGNKSLNTEEHMSLSQFFIEDFSASSGLAFYSS 250

Query: 239 TGKFTCIEVKFHLERQMGYYLIQMYIPSLLIVILSWVSFWINMDAAPARVGLGITTVLTM 298
           TG +  + + F L R + ++++Q Y P++L+V+LSWVSFWI+  A PARV LGITTVLTM
Sbjct: 251 TGWYNRLFINFVLRRHVFFFVLQTYFPAILMVMLSWVSFWIDRRAVPARVSLGITTVLTM 310

Query: 299 TTQSSGSRASLPKVSYVKAIDIWMAVCLLFVFAALLEYAAINFVS--RQHKEFIRLRRRQ 356
           +T  +   AS+P+VSY+KA+D+++ V  LFVF +++EYAA+N+++   + K+F +  +  
Sbjct: 311 STIITAVSASMPQVSYLKAVDVYLWVSSLFVFLSVIEYAAVNYLTTVEERKQFKKTGKIS 370

Query: 357 RRQRLEEDIIQESRF 371
           R   +  D +Q   F
Sbjct: 371 RMYNI--DAVQAMAF 383


>gi|189083734 gamma-aminobutyric acid (GABA) A receptor, alpha 1
           precursor [Homo sapiens]
          Length = 456

 Score =  244 bits (623), Expect = 1e-64
 Identities = 140/337 (41%), Positives = 208/337 (61%), Gaps = 15/337 (4%)

Query: 12  LLLWTLPGQVLLRVALAKEEVKSGTKGSQPMSPSDFLDKLMGRTSGYDARIRPNFKGPPV 71
           LLL TL G+   + +L ++E+K  T        +  LD+L+    GYD R+RP       
Sbjct: 16  LLLSTLTGRSYGQPSL-QDELKDNTTVF-----TRILDRLL---DGYDNRLRPGLGERVT 66

Query: 72  NVTCNIFINSFSSITKTTMDYRVNVFLRQQWNDPRLSYREYPDDSLDLDPSMLDSIWKPD 131
            V  +IF+ SF  ++   M+Y ++VF RQ W D RL ++  P   L L+  M   IW PD
Sbjct: 67  EVKTDIFVTSFGPVSDHDMEYTIDVFFRQSWKDERLKFKG-PMTVLRLNNLMASKIWTPD 125

Query: 132 LFFANEKGANFHEVTTDNKLLRIFKNGNVLYSIRLTLILSCLMDLKNFPMDIQTCTMQLE 191
            FF N K +  H +T  NKLLRI ++G +LY++RLT+   C M L++FPMD   C ++  
Sbjct: 126 TFFHNGKKSVAHNMTMPNKLLRITEDGTLLYTMRLTVRAECPMHLEDFPMDAHACPLKFG 185

Query: 192 SFGYTMKDLVFEWL-EDAPAVQVAE-GLTLPQF-ILRDEKDLGCCTKHYNTGKFTCIEVK 248
           S+ YT  ++V+EW  E A +V VAE G  L Q+ +L    D G      +TG++  +   
Sbjct: 186 SYAYTRAEVVYEWTREPARSVVVAEDGSRLNQYDLLGQTVDSGIVQS--STGEYVVMTTH 243

Query: 249 FHLERQMGYYLIQMYIPSLLIVILSWVSFWINMDAAPARVGLGITTVLTMTTQSSGSRAS 308
           FHL+R++GY++IQ Y+P ++ VILS VSFW+N ++ PAR   G+TTVLTMTT S  +R S
Sbjct: 244 FHLKRKIGYFVIQTYLPCIMTVILSQVSFWLNRESVPARTVFGVTTVLTMTTLSISARNS 303

Query: 309 LPKVSYVKAIDIWMAVCLLFVFAALLEYAAINFVSRQ 345
           LPKV+Y  A+D ++AVC  FVF+AL+E+A +N+ +++
Sbjct: 304 LPKVAYATAMDWFIAVCYAFVFSALIEFATVNYFTKR 340


>gi|189083732 gamma-aminobutyric acid (GABA) A receptor, alpha 1
           precursor [Homo sapiens]
          Length = 456

 Score =  244 bits (623), Expect = 1e-64
 Identities = 140/337 (41%), Positives = 208/337 (61%), Gaps = 15/337 (4%)

Query: 12  LLLWTLPGQVLLRVALAKEEVKSGTKGSQPMSPSDFLDKLMGRTSGYDARIRPNFKGPPV 71
           LLL TL G+   + +L ++E+K  T        +  LD+L+    GYD R+RP       
Sbjct: 16  LLLSTLTGRSYGQPSL-QDELKDNTTVF-----TRILDRLL---DGYDNRLRPGLGERVT 66

Query: 72  NVTCNIFINSFSSITKTTMDYRVNVFLRQQWNDPRLSYREYPDDSLDLDPSMLDSIWKPD 131
            V  +IF+ SF  ++   M+Y ++VF RQ W D RL ++  P   L L+  M   IW PD
Sbjct: 67  EVKTDIFVTSFGPVSDHDMEYTIDVFFRQSWKDERLKFKG-PMTVLRLNNLMASKIWTPD 125

Query: 132 LFFANEKGANFHEVTTDNKLLRIFKNGNVLYSIRLTLILSCLMDLKNFPMDIQTCTMQLE 191
            FF N K +  H +T  NKLLRI ++G +LY++RLT+   C M L++FPMD   C ++  
Sbjct: 126 TFFHNGKKSVAHNMTMPNKLLRITEDGTLLYTMRLTVRAECPMHLEDFPMDAHACPLKFG 185

Query: 192 SFGYTMKDLVFEWL-EDAPAVQVAE-GLTLPQF-ILRDEKDLGCCTKHYNTGKFTCIEVK 248
           S+ YT  ++V+EW  E A +V VAE G  L Q+ +L    D G      +TG++  +   
Sbjct: 186 SYAYTRAEVVYEWTREPARSVVVAEDGSRLNQYDLLGQTVDSGIVQS--STGEYVVMTTH 243

Query: 249 FHLERQMGYYLIQMYIPSLLIVILSWVSFWINMDAAPARVGLGITTVLTMTTQSSGSRAS 308
           FHL+R++GY++IQ Y+P ++ VILS VSFW+N ++ PAR   G+TTVLTMTT S  +R S
Sbjct: 244 FHLKRKIGYFVIQTYLPCIMTVILSQVSFWLNRESVPARTVFGVTTVLTMTTLSISARNS 303

Query: 309 LPKVSYVKAIDIWMAVCLLFVFAALLEYAAINFVSRQ 345
           LPKV+Y  A+D ++AVC  FVF+AL+E+A +N+ +++
Sbjct: 304 LPKVAYATAMDWFIAVCYAFVFSALIEFATVNYFTKR 340


  Database: hs.faa
    Posted date:  Aug 4, 2009  4:42 PM
  Number of letters in database: 18,247,518
  Number of sequences in database:  37,866
  
Lambda     K      H
   0.324    0.139    0.425 

Gapped
Lambda     K      H
   0.267   0.0410    0.140 


Matrix: BLOSUM62
Gap Penalties: Existence: 11, Extension: 1
Number of Hits to DB: 16,356,058
Number of Sequences: 37866
Number of extensions: 735540
Number of successful extensions: 2495
Number of sequences better than 10.0: 30
Number of HSP's better than 10.0 without gapping: 61
Number of HSP's successfully gapped in prelim test: 14
Number of HSP's that attempted gapping in prelim test: 2316
Number of HSP's gapped (non-prelim): 84
length of query: 417
length of database: 18,247,518
effective HSP length: 105
effective length of query: 312
effective length of database: 14,271,588
effective search space: 4452735456
effective search space used: 4452735456
T: 11
A: 40
X1: 15 ( 7.0 bits)
X2: 38 (14.6 bits)
X3: 64 (24.7 bits)
S1: 40 (21.5 bits)
S2: 63 (28.9 bits)
Search results were obtained with NCBI BLAST and RefSeq entries.