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Search of human proteins with 21735569
BLASTP 2.2.11 [Jun-05-2005]
Reference: Altschul, Stephen F., Thomas L. Madden, Alejandro A. Schaffer,
Jinghui Zhang, Zheng Zhang, Webb Miller, and David J. Lipman (1997),
"Gapped BLAST and PSI-BLAST: a new generation of protein database search
programs", Nucleic Acids Res. 25:3389-3402.
Query= gi|21735569 claspin [Homo sapiens]
(1339 letters)
Database: hs.faa
37,866 sequences; 18,247,518 total letters
Searching..................................................done
Score E
Sequences producing significant alignments: (bits) Value
gi|21735569 claspin [Homo sapiens] 2645 0.0
gi|84043963 eukaryotic translation initiation factor 5B [Homo sa... 81 8e-15
gi|17975763 myelin transcription factor 1 [Homo sapiens] 72 3e-12
gi|60498973 myelin transcription factor 1-like [Homo sapiens] 70 2e-11
gi|94536805 splicing factor YT521-B isoform 2 [Homo sapiens] 70 2e-11
gi|155030232 proline, glutamic acid and leucine rich protein 1 [... 69 2e-11
gi|20336205 transcriptional regulator ATRX isoform 2 [Homo sapiens] 69 2e-11
gi|20336209 transcriptional regulator ATRX isoform 1 [Homo sapiens] 69 2e-11
gi|239745095 PREDICTED: hypothetical protein LOC645202 [Homo sap... 67 1e-10
gi|148746195 trichohyalin [Homo sapiens] 67 1e-10
gi|32483416 neurofilament, heavy polypeptide 200kDa [Homo sapiens] 67 1e-10
gi|50897852 coiled-coil domain containing 88A isoform 2 [Homo sa... 67 1e-10
gi|208022632 coiled-coil domain containing 88A isoform 1 [Homo s... 67 1e-10
gi|72534750 splicing factor YT521-B isoform 1 [Homo sapiens] 66 2e-10
gi|221219020 NYD-SP11 protein [Homo sapiens] 65 4e-10
gi|4503257 death-domain associated protein isoform a [Homo sapiens] 64 1e-09
gi|215422388 death-domain associated protein isoform a [Homo sap... 64 1e-09
gi|215422366 death-domain associated protein isoform b [Homo sap... 64 1e-09
gi|34878904 synaptonemal complex protein 1 [Homo sapiens] 63 2e-09
gi|239745093 PREDICTED: hypothetical protein XP_002343359 [Homo ... 63 2e-09
gi|5454088 acidic (leucine-rich) nuclear phosphoprotein 32 famil... 63 2e-09
gi|169210053 PREDICTED: hypothetical protein [Homo sapiens] 61 6e-09
gi|225637560 NIMA-related kinase 11 isoform 1 [Homo sapiens] 61 6e-09
gi|6715600 golgi autoantigen, golgin subfamily a, 4 [Homo sapiens] 61 8e-09
gi|13569879 acidic (leucine-rich) nuclear phosphoprotein 32 fami... 61 8e-09
gi|38044112 restin isoform b [Homo sapiens] 60 1e-08
gi|4506751 restin isoform a [Homo sapiens] 60 1e-08
gi|21735415 centromere protein B [Homo sapiens] 60 1e-08
gi|189409130 zinc finger E-box binding homeobox 1 isoform a [Hom... 60 1e-08
gi|189409128 zinc finger E-box binding homeobox 1 isoform b [Hom... 60 1e-08
>gi|21735569 claspin [Homo sapiens]
Length = 1339
Score = 2645 bits (6855), Expect = 0.0
Identities = 1339/1339 (100%), Positives = 1339/1339 (100%)
Query: 1 MTGEVGSEVHLEINDPNVISQEEADSPSDSGQGSYETIGPLSEGDSDEEIFVSKKLKNRK 60
MTGEVGSEVHLEINDPNVISQEEADSPSDSGQGSYETIGPLSEGDSDEEIFVSKKLKNRK
Sbjct: 1 MTGEVGSEVHLEINDPNVISQEEADSPSDSGQGSYETIGPLSEGDSDEEIFVSKKLKNRK 60
Query: 61 VLQDSDSETEDTNASPEKTTYDSAEEENKENLYAGKNTKIKRIYKTVADSDESYMEKSLY 120
VLQDSDSETEDTNASPEKTTYDSAEEENKENLYAGKNTKIKRIYKTVADSDESYMEKSLY
Sbjct: 61 VLQDSDSETEDTNASPEKTTYDSAEEENKENLYAGKNTKIKRIYKTVADSDESYMEKSLY 120
Query: 121 QENLEAQVKPCLELSLQSGNSTDFTTDRKSSKKHIHDKEGTAGKAKVKSKRRLEKEERKM 180
QENLEAQVKPCLELSLQSGNSTDFTTDRKSSKKHIHDKEGTAGKAKVKSKRRLEKEERKM
Sbjct: 121 QENLEAQVKPCLELSLQSGNSTDFTTDRKSSKKHIHDKEGTAGKAKVKSKRRLEKEERKM 180
Query: 181 EKIRQLKKKETKNQEDDVEQPFNDSGCLLVDKDLFETGLEDENNSPLEDEESLESIRAAV 240
EKIRQLKKKETKNQEDDVEQPFNDSGCLLVDKDLFETGLEDENNSPLEDEESLESIRAAV
Sbjct: 181 EKIRQLKKKETKNQEDDVEQPFNDSGCLLVDKDLFETGLEDENNSPLEDEESLESIRAAV 240
Query: 241 KNKVKKHKKKEPSLESGVHSFEEGSELSKGTTRKERKAARLSKEALKQLHSETQRLIRES 300
KNKVKKHKKKEPSLESGVHSFEEGSELSKGTTRKERKAARLSKEALKQLHSETQRLIRES
Sbjct: 241 KNKVKKHKKKEPSLESGVHSFEEGSELSKGTTRKERKAARLSKEALKQLHSETQRLIRES 300
Query: 301 ALNLPYHMPENKTIHDFFKRKPRPTCHGNAMALLKSSKYQSSHHKEIIDTANTTEMNSDH 360
ALNLPYHMPENKTIHDFFKRKPRPTCHGNAMALLKSSKYQSSHHKEIIDTANTTEMNSDH
Sbjct: 301 ALNLPYHMPENKTIHDFFKRKPRPTCHGNAMALLKSSKYQSSHHKEIIDTANTTEMNSDH 360
Query: 361 HSKGSEQTTGAENEVETNALPVVSKETQIITGSDESCRKDLVKNEELEIQEKQKQSDIRP 420
HSKGSEQTTGAENEVETNALPVVSKETQIITGSDESCRKDLVKNEELEIQEKQKQSDIRP
Sbjct: 361 HSKGSEQTTGAENEVETNALPVVSKETQIITGSDESCRKDLVKNEELEIQEKQKQSDIRP 420
Query: 421 SPGDSSVLQQESNFLGNNHSEECQVGGLVAFEPHALEGEGPQNPEETDEKVEEPEQQNKS 480
SPGDSSVLQQESNFLGNNHSEECQVGGLVAFEPHALEGEGPQNPEETDEKVEEPEQQNKS
Sbjct: 421 SPGDSSVLQQESNFLGNNHSEECQVGGLVAFEPHALEGEGPQNPEETDEKVEEPEQQNKS 480
Query: 481 SAVGPPEKVRRFTLDRLKQLGVDVSIKPRLGADEDSFVILEPETNRELEALKQRFWKHAN 540
SAVGPPEKVRRFTLDRLKQLGVDVSIKPRLGADEDSFVILEPETNRELEALKQRFWKHAN
Sbjct: 481 SAVGPPEKVRRFTLDRLKQLGVDVSIKPRLGADEDSFVILEPETNRELEALKQRFWKHAN 540
Query: 541 PAAKPRAGQTVNVNVIVKDMGTDGKEELKADVVPVTLAPKKLDGASHTKPGEKLQVLKAK 600
PAAKPRAGQTVNVNVIVKDMGTDGKEELKADVVPVTLAPKKLDGASHTKPGEKLQVLKAK
Sbjct: 541 PAAKPRAGQTVNVNVIVKDMGTDGKEELKADVVPVTLAPKKLDGASHTKPGEKLQVLKAK 600
Query: 601 LQEAMKLRRFEERQKRQALFKLDNEDGFEEEEEEEEEMTDESEEDGEEKVEKEEKEEELE 660
LQEAMKLRRFEERQKRQALFKLDNEDGFEEEEEEEEEMTDESEEDGEEKVEKEEKEEELE
Sbjct: 601 LQEAMKLRRFEERQKRQALFKLDNEDGFEEEEEEEEEMTDESEEDGEEKVEKEEKEEELE 660
Query: 661 EEEEKEEEEEEEGNQETAEFLLSSEEIETKDEKEMDKENNDGSSEIGKAVGFLSVPKSLS 720
EEEEKEEEEEEEGNQETAEFLLSSEEIETKDEKEMDKENNDGSSEIGKAVGFLSVPKSLS
Sbjct: 661 EEEEKEEEEEEEGNQETAEFLLSSEEIETKDEKEMDKENNDGSSEIGKAVGFLSVPKSLS 720
Query: 721 SDSTLLLFKDSSSKMGYFPTEEKSETDENSGKQPSKLDEDDSCSLLTKESSHNSSFELIG 780
SDSTLLLFKDSSSKMGYFPTEEKSETDENSGKQPSKLDEDDSCSLLTKESSHNSSFELIG
Sbjct: 721 SDSTLLLFKDSSSKMGYFPTEEKSETDENSGKQPSKLDEDDSCSLLTKESSHNSSFELIG 780
Query: 781 STIPSYQPCNRQTGRGTSFFPTAGGFRSPSPGLFRASLVSSASKSSGKLSEPSLPIEDSQ 840
STIPSYQPCNRQTGRGTSFFPTAGGFRSPSPGLFRASLVSSASKSSGKLSEPSLPIEDSQ
Sbjct: 781 STIPSYQPCNRQTGRGTSFFPTAGGFRSPSPGLFRASLVSSASKSSGKLSEPSLPIEDSQ 840
Query: 841 DLYNASPEPKTLFLGAGDFQFCLEDDTQSQLLDADGFLNVRNHRNQYQALKPRLPLASMD 900
DLYNASPEPKTLFLGAGDFQFCLEDDTQSQLLDADGFLNVRNHRNQYQALKPRLPLASMD
Sbjct: 841 DLYNASPEPKTLFLGAGDFQFCLEDDTQSQLLDADGFLNVRNHRNQYQALKPRLPLASMD 900
Query: 901 ENAMDANMDELLDLCTGKFTSQAEKHLPRKSDKKENMEELLNLCSGKFTSQDASTPASSE 960
ENAMDANMDELLDLCTGKFTSQAEKHLPRKSDKKENMEELLNLCSGKFTSQDASTPASSE
Sbjct: 901 ENAMDANMDELLDLCTGKFTSQAEKHLPRKSDKKENMEELLNLCSGKFTSQDASTPASSE 960
Query: 961 LNKQEKESSMGDPMEEALALCSGSFPTDKEEEDEEEEFGDFRLVSNDNEFDSDEDEHSDS 1020
LNKQEKESSMGDPMEEALALCSGSFPTDKEEEDEEEEFGDFRLVSNDNEFDSDEDEHSDS
Sbjct: 961 LNKQEKESSMGDPMEEALALCSGSFPTDKEEEDEEEEFGDFRLVSNDNEFDSDEDEHSDS 1020
Query: 1021 GNDLALEDHEDDDEEELLKRSEKLKRQMRLRKYLEDEAEVSGSDVGSEDEYDGEEIDEYE 1080
GNDLALEDHEDDDEEELLKRSEKLKRQMRLRKYLEDEAEVSGSDVGSEDEYDGEEIDEYE
Sbjct: 1021 GNDLALEDHEDDDEEELLKRSEKLKRQMRLRKYLEDEAEVSGSDVGSEDEYDGEEIDEYE 1080
Query: 1081 EDVIDEVLPSDEELQSQIKKIHMKTMLDDDKRQLRLYQERYLADGDLHSDGPGRMRKFRW 1140
EDVIDEVLPSDEELQSQIKKIHMKTMLDDDKRQLRLYQERYLADGDLHSDGPGRMRKFRW
Sbjct: 1081 EDVIDEVLPSDEELQSQIKKIHMKTMLDDDKRQLRLYQERYLADGDLHSDGPGRMRKFRW 1140
Query: 1141 KNIDDASQMDLFHRDSDDDQTEEQLDESEARWRKERIEREQWLRDMAQQGKITAEEEEEI 1200
KNIDDASQMDLFHRDSDDDQTEEQLDESEARWRKERIEREQWLRDMAQQGKITAEEEEEI
Sbjct: 1141 KNIDDASQMDLFHRDSDDDQTEEQLDESEARWRKERIEREQWLRDMAQQGKITAEEEEEI 1200
Query: 1201 GEDSQFMILAKKVTAKALQKNASRPMVIQESKSLLRNPFEAIRPGSAQQVKTGSLLNQPK 1260
GEDSQFMILAKKVTAKALQKNASRPMVIQESKSLLRNPFEAIRPGSAQQVKTGSLLNQPK
Sbjct: 1201 GEDSQFMILAKKVTAKALQKNASRPMVIQESKSLLRNPFEAIRPGSAQQVKTGSLLNQPK 1260
Query: 1261 AVLQKLAALSDHNPSAPRNSRNFVFHTLSPVKAEAAKESSKSQVKKRGPSFMTSPSPKHL 1320
AVLQKLAALSDHNPSAPRNSRNFVFHTLSPVKAEAAKESSKSQVKKRGPSFMTSPSPKHL
Sbjct: 1261 AVLQKLAALSDHNPSAPRNSRNFVFHTLSPVKAEAAKESSKSQVKKRGPSFMTSPSPKHL 1320
Query: 1321 KTDDSTSGLTRSIFKYLES 1339
KTDDSTSGLTRSIFKYLES
Sbjct: 1321 KTDDSTSGLTRSIFKYLES 1339
>gi|84043963 eukaryotic translation initiation factor 5B [Homo
sapiens]
Length = 1220
Score = 80.9 bits (198), Expect = 8e-15
Identities = 147/677 (21%), Positives = 264/677 (38%), Gaps = 103/677 (15%)
Query: 52 VSKKLKNRKVLQDSDSETEDTNASPEKTTYDSAEEENKENLYAGKNTKIKRIYKTVADSD 111
+ KK KN+ +DS + D +A + A +E + GK K K+ D D
Sbjct: 1 MGKKQKNKS--EDSTKDDIDLDALAAEIEGAGAAKEQEPQKSKGKKKKEKK----KQDFD 54
Query: 112 ESYMEKSLYQENLEAQV----KPCLELSLQSGNSTDFTTDRKSSKKHIHDKEGTAGKAKV 167
E + K L + +LEAQ + + + N +FT+ K K ++G
Sbjct: 55 EDDILKELEELSLEAQGIKADRETVAVKPTENNEEEFTSKDKKKK----GQKGKKQSFDD 110
Query: 168 KSKRRLEKEERKMEKIRQLKKKETKNQEDDVE---QPFNDSGCLLVDKDLFETGLEDENN 224
LE ++ K +K + K + +DD + P G ++ EDE+N
Sbjct: 111 NDSEELEDKDSKSKKTAKPKVEMYSGSDDDDDFNKLPKKAKGKAQKSNKKWDGSEEDEDN 170
Query: 225 SPLEDE------------ESLESIRAAVKNKVKKHKKKEPSLESGVHSFEEGSELSKGTT 272
S E ES E +++ K + K P++ESG E+ K T
Sbjct: 171 SKKIKERSRINSSGESGDESDEFLQSRKGQKKNQKNKPGPNIESGN---EDDDASFKIKT 227
Query: 273 RKERKAARLSKEALKQLHSETQRLIRESALNLPYHMPENKTIHDFFKRKPRPTCHGNAMA 332
++KA + +E K+ E + +R+ K K
Sbjct: 228 VAQKKAEKKERERKKR--DEEKAKLRK------------------LKEKEE--------- 258
Query: 333 LLKSSKYQSSHHKEIIDTANTTEMNSDHHSKGSEQTTGAENEVETNALPVVSKETQIITG 392
L++ K S KE K E+T ++ V+T +P ++ + T
Sbjct: 259 -LETGKKDQSKQKE-------------SQRKFEEETVKSKVTVDTGVIPASEEKAETPTA 304
Query: 393 SDESCRKDLVKNEELEI--QEKQKQSDIRPSPGDSSVLQQESNFLGNNHSEECQVGGLVA 450
+++ D K ++ + ++++K+ + + P ++V + EE Q
Sbjct: 305 AEDDNEGDKKKKDKKKKKGEKEEKEKEKKKGPSKATVKAMQEALAKLKEEEERQ------ 358
Query: 451 FEPHALEGEGPQNPEETDEKVEEPE--QQNKSSAVGPPEKVRRFTLDRLKQLGVDVSIKP 508
E E + EE + K +E E +Q K EK R+ +RLK+ G + K
Sbjct: 359 ---KREEEERIKRLEELEAKRKEEERLEQEKRERKKQKEKERK---ERLKKEG-KLLTKS 411
Query: 509 RLGADEDSFVILEPETNRELEALKQRFWKHANPAAKPRAGQTVNVNVIVKDMGTDGKEEL 568
+ A + L+ + +E + P + + + + + K++ ++ E
Sbjct: 412 QREARARAEATLKLLQAQGVEVPSKDSLPKKRPIYEDKKRKKIPQQLESKEV-SESMELC 470
Query: 569 KADVVPVTLAPKKLDGASHTKPGEKLQVLKAKLQEAMKLRRFEERQKRQALFKLDNEDGF 628
A V P+K + +P E+ A L + + EE +K + N+
Sbjct: 471 AAVEVMEQGVPEKEETPPPVEPEEEEDTEDAGLDDWEAMASDEETEKVEG-----NKVHI 525
Query: 629 EEEEEEEEEMTDESEEDGEEKVEKEEKEEELEEEEEKEEEEEEEGNQETAEFLLSSEEIE 688
E +E EEE EE+ EE+ E EE EEE EEE E E E +E +++ ++ S + ++
Sbjct: 526 EVKENPEEE-----EEEEEEEEEDEESEEEEEEEGESEGSEGDEEDEKVSDEKDSGKTLD 580
Query: 689 TKDEKEMDKENNDGSSE 705
K KEM ++ S +
Sbjct: 581 KKPSKEMSSDSEYDSDD 597
Score = 56.6 bits (135), Expect = 2e-07
Identities = 133/622 (21%), Positives = 232/622 (37%), Gaps = 85/622 (13%)
Query: 22 EEADSPSDSGQGSYETIGPLSEGDSDEEIFVSKKLKNRKVLQDSDSETEDTNASPEKTTY 81
EE + + ET+ + +++EE F SK K + Q ++ D N S E
Sbjct: 63 EELSLEAQGIKADRETVA-VKPTENNEEEFTSKDKKKKG--QKGKKQSFDDNDSEELEDK 119
Query: 82 DSAEEEN---KENLYAGKN-----TKIKRIYKTVADSDESYMEKSLYQENLEAQVKPCLE 133
DS ++ K +Y+G + K+ + K A + S E+ ++K
Sbjct: 120 DSKSKKTAKPKVEMYSGSDDDDDFNKLPKKAKGKAQKSNKKWDGSEEDEDNSKKIKERSR 179
Query: 134 L--SLQSGNSTD-FTTDRKSSKKHIHDKEG-----------TAGKAKVKSKRRLEKEERK 179
+ S +SG+ +D F RK KK+ +K G + K K ++++ EK+ER+
Sbjct: 180 INSSGESGDESDEFLQSRKGQKKNQKNKPGPNIESGNEDDDASFKIKTVAQKKAEKKERE 239
Query: 180 MEK-------IRQLKKKE-----TKNQEDDVEQPFNDSGCLLVDKDLFETGLEDENNSPL 227
+K +R+LK+KE K+Q E + K +TG+ +
Sbjct: 240 RKKRDEEKAKLRKLKEKEELETGKKDQSKQKESQRKFEEETVKSKVTVDTGVIPASEEKA 299
Query: 228 EDEESLESIRAAVKNKVKKHKKKEPSLESGVHSFEEGSELSKGTTRKERKA-ARLSKEAL 286
E + E K K K KKK E E+ SK T + ++A A+L +E
Sbjct: 300 ETPTAAEDDNEGDKKKKDKKKKKGEKEEK---EKEKKKGPSKATVKAMQEALAKLKEEEE 356
Query: 287 KQLHSETQRLIRESALNLPYHMPENKTIHDFFKRKPRPTCHGNAMALLKSSKYQSSHHKE 346
+Q E +R+ R L E + + + + + L K K + +E
Sbjct: 357 RQKREEEERIKRLEELEA--KRKEEERLEQEKRERKKQKEKERKERLKKEGKLLTKSQRE 414
Query: 347 IIDTANTT-----EMNSDHHSKGSEQTTGAENEVETNALPVVSKETQIITGSDESC---- 397
A T + SK S E + E++ ++ S E C
Sbjct: 415 ARARAEATLKLLQAQGVEVPSKDSLPKKRPIYEDKKRKKIPQQLESKEVSESMELCAAVE 474
Query: 398 --RKDLVKNEE----LEIQEKQKQSDIRPSPGDSSVLQQESNFLGNNHSEECQVGGLVAF 451
+ + + EE +E +E++ D ++ +E+ + N +
Sbjct: 475 VMEQGVPEKEETPPPVEPEEEEDTEDAGLDDWEAMASDEETEKVEGNKVH-------IEV 527
Query: 452 EPHALEGEGPQNPEETDEKVEEPEQQNKSSAVGPPEKVRRFTLDRLKQLGVDVSIKPRLG 511
+ + E E + EE DE+ EE E++ S ++ D K G + KP
Sbjct: 528 KENPEEEEEEEEEEEEDEESEEEEEEEGESEGSEGDEEDEKVSDE-KDSGKTLDKKPSKE 586
Query: 512 ADEDSFVILEPETNRELEALKQRFWKHANPAAKPRAGQTVNVNVIVKDMGTDGKEELKAD 571
DS + + +E ++ + K K R + NVN E+L+A
Sbjct: 587 MSSDSEYDSDDDRTKE----ERAYDKAKRRIEKRRLEHSKNVNT----------EKLRAP 632
Query: 572 VVPV-----TLAPKKLDGASHT 588
++ V T K LD HT
Sbjct: 633 IICVLGHVDTGKTKILDKLRHT 654
Score = 51.2 bits (121), Expect = 7e-06
Identities = 119/617 (19%), Positives = 248/617 (40%), Gaps = 67/617 (10%)
Query: 530 ALKQRFWKHANPAAKPRAGQTVNVNVIVKDMGTDGKEE--LKADVVPVTLAPKKLDGASH 587
A +Q K K + Q + + I+K++ E +KAD V + P + +
Sbjct: 32 AKEQEPQKSKGKKKKEKKKQDFDEDDILKELEELSLEAQGIKADRETVAVKPTENNEEEF 91
Query: 588 TKPGEKLQVLKAKLQ-----EAMKLRRFEERQKRQALFKLDNEDGFEEEEEEEEEMTDES 642
T +K + K K Q ++ +L + + K+ A K++ G +++++ ++ ++
Sbjct: 92 TSKDKKKKGQKGKKQSFDDNDSEELEDKDSKSKKTAKPKVEMYSG-SDDDDDFNKLPKKA 150
Query: 643 EEDGEEKVEKEEKEEELEEEEEKEEEEEE-----EGNQETAEFLLSSEEIETKDEKEMDK 697
+ ++ +K + EE E+ +K +E E E+ EFL S + + K++K
Sbjct: 151 KGKAQKSNKKWDGSEEDEDNSKKIKERSRINSSGESGDESDEFL-QSRKGQKKNQKNKPG 209
Query: 698 ENNDGSSEIGKA---VGFLSVPKSLSSDSTLLLFKDSSSKMGYFPTEEKSET---DENSG 751
N + +E A + ++ K+ + + +K+ +E+ ET D++
Sbjct: 210 PNIESGNEDDDASFKIKTVAQKKAEKKERERKKRDEEKAKLRKLKEKEELETGKKDQSKQ 269
Query: 752 KQPS-KLDEDDSCSLLTKESSHNSSFELIGSTIPSYQPCN--------RQTGRGTSFFPT 802
K+ K +E+ S +T ++ + E T + + N ++ +G
Sbjct: 270 KESQRKFEEETVKSKVTVDTGVIPASEEKAETPTAAEDDNEGDKKKKDKKKKKGEKEEKE 329
Query: 803 AGGFRSPSPGLFRA---SLVSSASKSSGKLSEPSLPIEDSQDLYNASPEPKTLFLGAGDF 859
+ PS +A +L + + E I+ ++L E + L +
Sbjct: 330 KEKKKGPSKATVKAMQEALAKLKEEEERQKREEEERIKRLEELEAKRKEEERLEQEKRER 389
Query: 860 QFCLEDDTQSQLLDADGFLNVRNHRNQYQALKPRLPLASMDENAMDANMDELLDLCTGKF 919
+ E + + +L +G L ++ R + L L + ++ + L +
Sbjct: 390 KKQKEKERKERL-KKEGKLLTKSQREARARAEATLKL--LQAQGVEVPSKDSLPKKRPIY 446
Query: 920 TSQAEKHLPRKSDKKENMEELLNLCSGKFTSQDASTPASSELNKQEKESSMGDPMEEALA 979
+ K +P++ + KE + E + LC A+ E+ +Q G P +E
Sbjct: 447 EDKKRKKIPQQLESKE-VSESMELC------------AAVEVMEQ------GVPEKEETP 487
Query: 980 LCSGSFPTDKEEEDEEEEFGDFRLVSNDNEFDSDEDEHSDSGNDLALEDHEDDDEEELLK 1039
P + EEE++ E+ G + + SDE+ GN + +E E+ +EEE +
Sbjct: 488 P-----PVEPEEEEDTEDAG----LDDWEAMASDEETEKVEGNKVHIEVKENPEEEE--E 536
Query: 1040 RSEKLKRQMRLRKYLEDEAEVSGSDVGSEDEYDGEEIDEYE--EDVIDEVLPSDEELQSQ 1097
E+ + + E+E E GS+ EDE +E D + + + + SD E S
Sbjct: 537 EEEEEEEDEESEEEEEEEGESEGSEGDEEDEKVSDEKDSGKTLDKKPSKEMSSDSEYDSD 596
Query: 1098 IKKIHMKTMLDDDKRQL 1114
+ + D KR++
Sbjct: 597 DDRTKEERAYDKAKRRI 613
Score = 40.8 bits (94), Expect = 0.009
Identities = 125/640 (19%), Positives = 256/640 (40%), Gaps = 109/640 (17%)
Query: 630 EEEEEEEEMTDESEEDGEEKVEKEEKEEELEEEEEKEEE-EEEEGNQETAEFLLSSEEI- 687
+++ + + + E E G K ++ +K + +++E+K+++ +E++ +E E L ++ I
Sbjct: 14 KDDIDLDALAAEIEGAGAAKEQEPQKSKGKKKKEKKKQDFDEDDILKELEELSLEAQGIK 73
Query: 688 ---ETKDEKEMDKENNDGSSEIGKAVGFLSVPKSLS-SDSTLLLFKDSSSKMGYFPTEEK 743
ET K + + +S+ K G +S +DS L KDS SK K
Sbjct: 74 ADRETVAVKPTENNEEEFTSKDKKKKGQKGKKQSFDDNDSEELEDKDSKSKK-----TAK 128
Query: 744 SETDENSGKQPSKLDEDDSCSLLTKESSHNSSFELIGSTIPSYQPCNRQTGRGTSFFPTA 803
+ + SG D+DD + L K++ + Q N++ + +
Sbjct: 129 PKVEMYSGS-----DDDDDFNKLPKKAKGKA------------QKSNKK-------WDGS 164
Query: 804 GGFRSPSPGLFRASLVSSASKSSGKLSEPSLPIEDSQDLYNASPEPKTLFLGAGDFQFCL 863
S + S ++S+ +S + E + + P P + +G+
Sbjct: 165 EEDEDNSKKIKERSRINSSGESGDESDEFLQSRKGQKKNQKNKPGPN---IESGN----- 216
Query: 864 EDDTQSQLLDADGFLNVRNHRNQYQALKPRLPLASMDENAMDANMDELLDLCTGKFTSQA 923
EDD D ++ + K R +E A + E +L TGK
Sbjct: 217 EDD--------DASFKIKTVAQKKAEKKERERKKRDEEKAKLRKLKEKEELETGKKDQSK 268
Query: 924 EKHLPRKSDKKENMEELLNLCSGKFTSQD--ASTPASSELNKQEKESSMGDPMEEALALC 981
+K RK ++ E ++ + + +G + + A TP ++E + + GD ++
Sbjct: 269 QKESQRKFEE-ETVKSKVTVDTGVIPASEEKAETPTAAE------DDNEGDKKKKDKKKK 321
Query: 982 SGSFPTDKEEEDEEEEFGDFRL-VSNDNEFDSDEDEHSDSGNDLALEDHEDDDEEELLKR 1040
G +KEE+++E++ G + V E + E E+ + +EEE +KR
Sbjct: 322 KG----EKEEKEKEKKKGPSKATVKAMQEALAKLKEE---------EERQKREEEERIKR 368
Query: 1041 SEKLKRQMRLRKYLEDEAEVSGSDVGSEDEY----DGEEIDEYEEDVIDEVLPSDEELQS 1096
E+L+ + + + LE E E + +G+ + + + + + + LQ+
Sbjct: 369 LEELEAKRKEEERLEQEKRERKKQKEKERKERLKKEGKLLTKSQREARARAEATLKLLQA 428
Query: 1097 QIKKIHMKTMLD------DDKRQLRLYQE----------RYLADGDLHSDG-------PG 1133
Q ++ K L +DK++ ++ Q+ A ++ G P
Sbjct: 429 QGVEVPSKDSLPKKRPIYEDKKRKKIPQQLESKEVSESMELCAAVEVMEQGVPEKEETPP 488
Query: 1134 RMRKFRWKNIDDASQMDLFHRDSDDDQTEEQLDESEARWRKERIEREQWLRDMAQQGKIT 1193
+ ++ +DA +D + + D++TE+ KE E E+ + ++ + +
Sbjct: 489 PVEPEEEEDTEDAG-LDDWEAMASDEETEKVEGNKVHIEVKENPEEEEEEEEEEEEDEES 547
Query: 1194 AEEEEEIGE-------DSQFMILAKKVTAKALQKNASRPM 1226
EEEEE GE + + +K + K L K S+ M
Sbjct: 548 EEEEEEEGESEGSEGDEEDEKVSDEKDSGKTLDKKPSKEM 587
Score = 38.9 bits (89), Expect = 0.033
Identities = 120/644 (18%), Positives = 225/644 (34%), Gaps = 84/644 (13%)
Query: 588 TKPGEKLQVLKAKLQEAMKLRRFEERQKRQALFKLDNEDGFEEEE--EEEEEMTDESEED 645
TK L L A+++ A + E ++ + K + F+E++ +E EE++ E++
Sbjct: 13 TKDDIDLDALAAEIEGAGAAKEQEPQKSKGKKKKEKKKQDFDEDDILKELEELSLEAQGI 72
Query: 646 GEEKVEKEEKEEELEEEEEKEEEEEEEGNQETAEFL--LSSEEIETKDEKEMDKENNDGS 703
++ K E EEE ++++++G + + SEE+E KD K
Sbjct: 73 KADRETVAVKPTENNEEEFTSKDKKKKGQKGKKQSFDDNDSEELEDKDSKS--------- 123
Query: 704 SEIGKAVGFLSVPKSLSSDSTLLLFKDSSSKMGYFPTEEKSETDENSGKQPSKLDEDDSC 763
K+ + D P + K + +++ K +++D+
Sbjct: 124 ------------KKTAKPKVEMYSGSDDDDDFNKLPKKAKGKAQKSNKKWDGSEEDEDNS 171
Query: 764 SLLTKESSHNSSFELIGSTIPSYQPCNRQ-TGRGTSFFPTAGGFRSPSPGLFRASLVSSA 822
+ + S NSS E + Q Q + P F+ V A
Sbjct: 172 KKIKERSRINSSGESGDESDEFLQSRKGQKKNQKNKPGPNIESGNEDDDASFKIKTV--A 229
Query: 823 SKSSGKLSEPSLPIEDSQDLYNASPEPKTLFLGAGDFQFCLEDDTQSQLLDADGFLNVRN 882
K + K ++ + E + L G D E + + + V
Sbjct: 230 QKKAEKKERERKKRDEEKAKLRKLKEKEELETGKKDQSKQKESQRKFEEETVKSKVTVDT 289
Query: 883 HRNQYQALKPRLPLASMDENAMDANMDELLDLCTGKFTSQAEKHL-PRKSDKKENMEELL 941
K P A+ D+N D + K + EK P K+ K E L
Sbjct: 290 GVIPASEEKAETPTAAEDDNEGDKKKKDKKKKKGEKEEKEKEKKKGPSKATVKAMQEALA 349
Query: 942 NLCSGKFTSQDASTPASSELNKQEKESSMGDPMEEALALCSGSFPTDKEEEDEEEEFGDF 1001
L ++ E K+ +E EE L KE+E +E +
Sbjct: 350 KLKE----EEERQKREEEERIKRLEELEAKRKEEERLEQEKRERKKQKEKERKERLKKEG 405
Query: 1002 RLVSNDNEFDSDEDEHS-----DSGNDLALED--------HEDDDEEELLKRSEKLKRQM 1048
+L++ E + G ++ +D +ED K+ +K+ +Q+
Sbjct: 406 KLLTKSQREARARAEATLKLLQAQGVEVPSKDSLPKKRPIYED-------KKRKKIPQQL 458
Query: 1049 RLRKYLED-----EAEVSGSDVGSEDEYDGEEIDEYEEDVID------EVLPSDEELQS- 1096
++ E EV V ++E E EED D E + SDEE +
Sbjct: 459 ESKEVSESMELCAAVEVMEQGVPEKEETPPPVEPEEEEDTEDAGLDDWEAMASDEETEKV 518
Query: 1097 QIKKIHMKTMLDDDKRQLRLYQERYLADGDLHSDGPGRM--------------RKFRWKN 1142
+ K+H++ + ++ + +E + + + G K K
Sbjct: 519 EGNKVHIEVKENPEEEEEEEEEEEEDEESEEEEEEEGESEGSEGDEEDEKVSDEKDSGKT 578
Query: 1143 IDDASQMDL---FHRDSDDDQTEEQ--LDESEARWRKERIEREQ 1181
+D ++ DSDDD+T+E+ D+++ R K R+E +
Sbjct: 579 LDKKPSKEMSSDSEYDSDDDRTKEERAYDKAKRRIEKRRLEHSK 622
Score = 37.0 bits (84), Expect = 0.13
Identities = 39/180 (21%), Positives = 70/180 (38%), Gaps = 39/180 (21%)
Query: 16 PNVISQEEADSPSDSGQGSYETIGPLSEGDSDEEIFVSKKLKNRKVLQDSDSETEDTNAS 75
P + EE + D+G +E + SDEE ++K++ KV + E+
Sbjct: 487 PPPVEPEEEEDTEDAGLDDWEAMA------SDEE---TEKVEGNKVHIEVKENPEEEEEE 537
Query: 76 PEKTTYDSAEEENKENLYAGKNTKIKRIYKTVADSDESYMEKSLYQENLEAQVKPCLELS 135
E+ D EE +E + ++ + V+D +S
Sbjct: 538 EEEEEEDEESEEEEEEEGESEGSEGDEEDEKVSDEKDSGK-------------------- 577
Query: 136 LQSGNSTDFTTDRKSSKKHIHDKEGTAGKAKVKSKRRLEKEERKMEKIRQLKKKETKNQE 195
T D+K SK+ D E + + K +R +K +R++EK R+L+ + N E
Sbjct: 578 ---------TLDKKPSKEMSSDSEYDSDDDRTKEERAYDKAKRRIEK-RRLEHSKNVNTE 627
Score = 35.8 bits (81), Expect = 0.28
Identities = 76/372 (20%), Positives = 147/372 (39%), Gaps = 58/372 (15%)
Query: 963 KQEKESSMGDPME-EALALCSGSFPTDKEEEDEEEEFGDFRLVSNDNEFDSDEDEHSDSG 1021
K + E S D ++ +ALA KE+E ++ + + + D DED+
Sbjct: 6 KNKSEDSTKDDIDLDALAAEIEGAGAAKEQEPQKSKG---KKKKEKKKQDFDEDDILKEL 62
Query: 1022 NDLALE------DHE-------DDDEEELLKRSEKLKRQMRLRKYLEDEAEVSGSDVGSE 1068
+L+LE D E +++EEE + +K K Q ++ +D D S+
Sbjct: 63 EELSLEAQGIKADRETVAVKPTENNEEEFTSKDKKKKGQKGKKQSFDDNDSEELEDKDSK 122
Query: 1069 DEYDGE-EIDEYE-EDVIDEVLPSDEELQSQIKKIHMK---TMLDDDKRQLRLYQERYLA 1123
+ + +++ Y D D+ ++ + + +K + K + D+D + + R +
Sbjct: 123 SKKTAKPKVEMYSGSDDDDDFNKLPKKAKGKAQKSNKKWDGSEEDEDNSKKIKERSRINS 182
Query: 1124 DGDL--HSDGPGRMRKFRWKNIDDASQMDLFHRDSDDDQTEEQLDESEARWRKERIEREQ 1181
G+ SD + RK + KN + ++ + DDD + + ++ + K+ ER++
Sbjct: 183 SGESGDESDEFLQSRKGQKKNQKNKPGPNIESGNEDDDASFKIKTVAQKKAEKKERERKK 242
Query: 1182 WLRDMAQQGKITAEEEEEIGEDSQFMILAKKVTAKALQKNASRPMVIQESKSLLRNPFEA 1241
+ A+ K+ +EE E G+ Q + QK + R FE
Sbjct: 243 RDEEKAKLRKLKEKEELETGKKDQ-----------SKQKESQR-------------KFEE 278
Query: 1242 IRPGSAQQVKTGSLLNQPKAVLQKLAALSDHNPSAPRNSRNFVFHTLSPVKAEAAKESSK 1301
S V TG + + AA D+ + + K + ++ K
Sbjct: 279 ETVKSKVTVDTGVIPASEEKAETPTAAEDDNEGDKKKKDK----------KKKKGEKEEK 328
Query: 1302 SQVKKRGPSFMT 1313
+ KK+GPS T
Sbjct: 329 EKEKKKGPSKAT 340
Score = 34.3 bits (77), Expect = 0.82
Identities = 64/318 (20%), Positives = 121/318 (38%), Gaps = 63/318 (19%)
Query: 20 SQEEADSPSDSGQGSYETIGPLSEGDSDEEIFVSKKLKNRKVLQDSDSETEDTNASPEKT 79
S+E+A++P+ + + EGD KK +K + + + ++ P K
Sbjct: 295 SEEKAETPTAAEDDN--------EGDK-------KKKDKKKKKGEKEEKEKEKKKGPSKA 339
Query: 80 TYDSAEE------ENKENLYAGKNTKIKRIYKTVADSDESYMEKSLYQENLEAQVKPCLE 133
T + +E E +E + +IKR+ + A E + +E + + K E
Sbjct: 340 TVKAMQEALAKLKEEEERQKREEEERIKRLEELEAKRKEEERLEQEKRERKKQKEKERKE 399
Query: 134 LSLQSGNSTDFTTDRKSSKKHIHDKEGTAGKAKVKSKRRLEK-----EERKMEKI-RQLK 187
+ G + ++ K A +V SK L K E++K +KI +QL+
Sbjct: 400 RLKKEGKLLTKSQREARARAEATLKLLQAQGVEVPSKDSLPKKRPIYEDKKRKKIPQQLE 459
Query: 188 KKETKNQ------------------------EDDVEQPFNDSGCLLVDKDLFETGLEDEN 223
KE E + E+ D+G D +E DE
Sbjct: 460 SKEVSESMELCAAVEVMEQGVPEKEETPPPVEPEEEEDTEDAGL-----DDWEAMASDEE 514
Query: 224 NSPLEDEESLESIRAAVKNKVKKHKKKEPSLESGVHSFEEG-SELSKGTTRKER------ 276
+E + ++ + + ++ +++E ES EEG SE S+G E+
Sbjct: 515 TEKVEGNKVHIEVKENPEEEEEEEEEEEEDEESEEEEEEEGESEGSEGDEEDEKVSDEKD 574
Query: 277 KAARLSKEALKQLHSETQ 294
L K+ K++ S+++
Sbjct: 575 SGKTLDKKPSKEMSSDSE 592
>gi|17975763 myelin transcription factor 1 [Homo sapiens]
Length = 1121
Score = 72.4 bits (176), Expect = 3e-12
Identities = 38/62 (61%), Positives = 47/62 (75%), Gaps = 1/62 (1%)
Query: 611 EERQKRQALFKLDNEDGFEEEEEEEEEMTDESEEDGEEKVEKEEKEEELEEEEEKEEEEE 670
EE K++ + + ED EEEEEEEEE DE EE+ EE+ E+EE+EEE EEEEE+EEEEE
Sbjct: 246 EESSKQKGILSHEEEDE-EEEEEEEEEEEDEEEEEEEEEEEEEEEEEEEEEEEEEEEEEE 304
Query: 671 EE 672
EE
Sbjct: 305 EE 306
Score = 68.9 bits (167), Expect = 3e-11
Identities = 34/50 (68%), Positives = 41/50 (82%)
Query: 629 EEEEEEEEEMTDESEEDGEEKVEKEEKEEELEEEEEKEEEEEEEGNQETA 678
EEE+EEEEE +E EED EE+ E+EE+EEE EEEEE+EEEEEEE +E A
Sbjct: 258 EEEDEEEEEEEEEEEEDEEEEEEEEEEEEEEEEEEEEEEEEEEEEEEEEA 307
Score = 65.1 bits (157), Expect = 4e-10
Identities = 46/147 (31%), Positives = 76/147 (51%), Gaps = 12/147 (8%)
Query: 548 GQTVNVNVIVKDMGTDGKEELKADVVPVTLAPKKLDGASHTKPGEKLQVLKAKLQEAMKL 607
GQ ++ +D+G + K V L + +GA+ + + L + +E +++
Sbjct: 172 GQIAEETLVEEDLG----QAAKPGPGIVHLLQEAAEGAASEEGEKGLFIQPEDAEEVVEV 227
Query: 608 RRFEERQKRQALFKLDNEDGFEEEEEEEEEMTDESEEDGEEKVEKEEKEEELEEEEEKEE 667
++ Q L ED EE +++ + EED EE+ E+EE+EE+ EEEEE+EE
Sbjct: 228 TT----ERSQDLCPQSLEDAASEESSKQKGILSHEEEDEEEEEEEEEEEEDEEEEEEEEE 283
Query: 668 EEEEEGNQETAEFLLSSEEIETKDEKE 694
EEEEE +E E EE E ++E+E
Sbjct: 284 EEEEEEEEEEEE----EEEEEEEEEEE 306
Score = 55.5 bits (132), Expect = 3e-07
Identities = 40/130 (30%), Positives = 63/130 (48%), Gaps = 5/130 (3%)
Query: 576 TLAPKKLDGASHTKPGEKLQVLKAKLQEAMKLRRFEERQKRQALFKLDNEDGFEEEEEEE 635
TL + L A+ PG + LQEA + EE +K + D E+ E E
Sbjct: 178 TLVEEDLGQAAKPGPG-----IVHLLQEAAEGAASEEGEKGLFIQPEDAEEVVEVTTERS 232
Query: 636 EEMTDESEEDGEEKVEKEEKEEELEEEEEKEEEEEEEGNQETAEFLLSSEEIETKDEKEM 695
+++ +S ED + ++K EEE++EEEEEEE +E E EE E ++E+E
Sbjct: 233 QDLCPQSLEDAASEESSKQKGILSHEEEDEEEEEEEEEEEEDEEEEEEEEEEEEEEEEEE 292
Query: 696 DKENNDGSSE 705
++E + E
Sbjct: 293 EEEEEEEEEE 302
Score = 39.3 bits (90), Expect = 0.026
Identities = 22/85 (25%), Positives = 41/85 (48%), Gaps = 7/85 (8%)
Query: 952 DASTPASSELNKQEKESSMGDPMEEALALCSGSFPTDKEEEDEEEEFGDFRLVSNDNEFD 1011
+ +T S +L Q E + + + + S ++EEE+EEEE D E +
Sbjct: 226 EVTTERSQDLCPQSLEDAASEESSKQKGILSHEEEDEEEEEEEEEE-------EEDEEEE 278
Query: 1012 SDEDEHSDSGNDLALEDHEDDDEEE 1036
+E+E + + E+ E+++EEE
Sbjct: 279 EEEEEEEEEEEEEEEEEEEEEEEEE 303
Score = 37.7 bits (86), Expect = 0.075
Identities = 29/126 (23%), Positives = 53/126 (42%), Gaps = 17/126 (13%)
Query: 911 LLDLCTGKFTSQAEKHLPRKSDKKENMEELLNLCSGKFTSQDASTPASSELNKQEKESSM 970
L + G + + EK L + + E + E+ S Q AS E +KQ+
Sbjct: 198 LQEAAEGAASEEGEKGLFIQPEDAEEVVEVTTERSQDLCPQSLEDAASEESSKQK----- 252
Query: 971 GDPMEEALALCSGSFPTDKEEEDEEEEFGDFRLVSNDNEFDSDEDEHSDSGNDLALEDHE 1030
G ++E+E+EEEE + + E + +E+E + + E+ E
Sbjct: 253 ------------GILSHEEEDEEEEEEEEEEEEDEEEEEEEEEEEEEEEEEEEEEEEEEE 300
Query: 1031 DDDEEE 1036
+++EEE
Sbjct: 301 EEEEEE 306
Score = 37.0 bits (84), Expect = 0.13
Identities = 35/157 (22%), Positives = 66/157 (42%), Gaps = 38/157 (24%)
Query: 951 QDASTPASSE-------LNKQEKESSMGDPMEEALALCSGSFPTDKEEEDEEEEFGDFRL 1003
Q+A+ A+SE + ++ E + E + LC P E+ EE +
Sbjct: 199 QEAAEGAASEEGEKGLFIQPEDAEEVVEVTTERSQDLC----PQSLEDAASEESSKQKGI 254
Query: 1004 VSNDNEFDSDEDEHSDSGNDLALEDHEDDDEEELLKRSEKLKRQMRLRKYLEDEAEVSGS 1063
+S++ E + +E+E E+ E+D+EEE E+E E
Sbjct: 255 LSHEEEDEEEEEEE---------EEEEEDEEEE------------------EEEEEEEEE 287
Query: 1064 DVGSEDEYDGEEIDEYEEDVIDEVLPSDEELQSQIKK 1100
+ E+E + EE +E EE+ +V+ ++ + +K
Sbjct: 288 EEEEEEEEEEEEEEEEEEEAAPDVIFQEDTSHTSAQK 324
Score = 34.3 bits (77), Expect = 0.82
Identities = 30/137 (21%), Positives = 61/137 (44%), Gaps = 15/137 (10%)
Query: 571 DVVPVT------LAPKKLDGASHTKPGEKLQVLK-----AKLQEAMKLRRFEERQKRQAL 619
+VV VT L P+ L+ A+ + ++ +L + +E + +E ++ +
Sbjct: 223 EVVEVTTERSQDLCPQSLEDAASEESSKQKGILSHEEEDEEEEEEEEEEEEDEEEEEEEE 282
Query: 620 FKLDNEDGFEEEEEEEEEMTDESEEDGEEKVEKEEKEEELEEEEEKEEEEEEEGNQETAE 679
+ + E+ EEEEEEEEE +E E + +++ ++ E E E +
Sbjct: 283 EEEEEEEEEEEEEEEEEEEEEEEEAAPDVIFQEDTSHTSAQKAPELRGPESPSPKPEYSV 342
Query: 680 FLLSSEEIETKDEKEMD 696
+ E+ + D+K+ D
Sbjct: 343 IV----EVRSDDDKDED 355
Score = 34.3 bits (77), Expect = 0.82
Identities = 19/70 (27%), Positives = 36/70 (51%)
Query: 1151 LFHRDSDDDQTEEQLDESEARWRKERIEREQWLRDMAQQGKITAEEEEEIGEDSQFMILA 1210
L H + D+++ EE+ +E E +E E E+ + ++ + EEEEE E + +I
Sbjct: 255 LSHEEEDEEEEEEEEEEEEDEEEEEEEEEEEEEEEEEEEEEEEEEEEEEEEEAAPDVIFQ 314
Query: 1211 KKVTAKALQK 1220
+ + + QK
Sbjct: 315 EDTSHTSAQK 324
Score = 31.6 bits (70), Expect = 5.3
Identities = 17/79 (21%), Positives = 40/79 (50%)
Query: 1144 DDASQMDLFHRDSDDDQTEEQLDESEARWRKERIEREQWLRDMAQQGKITAEEEEEIGED 1203
+ + Q + + +D++ EE+ +E E +E E E+ + ++ + EEEEE E+
Sbjct: 247 ESSKQKGILSHEEEDEEEEEEEEEEEEDEEEEEEEEEEEEEEEEEEEEEEEEEEEEEEEE 306
Query: 1204 SQFMILAKKVTAKALQKNA 1222
+ ++ ++ T+ + A
Sbjct: 307 AAPDVIFQEDTSHTSAQKA 325
>gi|60498973 myelin transcription factor 1-like [Homo sapiens]
Length = 1184
Score = 69.7 bits (169), Expect = 2e-11
Identities = 35/104 (33%), Positives = 64/104 (61%)
Query: 598 KAKLQEAMKLRRFEERQKRQALFKLDNEDGFEEEEEEEEEMTDESEEDGEEKVEKEEKEE 657
K + A K + F + ++ + D+ DG E+ +E+EE+ +E ED +E +++E++E
Sbjct: 66 KQPQEPAPKRKPFAVKADSSSVDECDDSDGTEDMDEKEEDEGEEYSEDNDEPGDEDEEDE 125
Query: 658 ELEEEEEKEEEEEEEGNQETAEFLLSSEEIETKDEKEMDKENND 701
E + EEE+E EEE+E + E E + EE E ++E+E ++E N+
Sbjct: 126 EGDREEEEEIEEEDEDDDEDGEDVEDEEEEEEEEEEEEEEEENE 169
Score = 62.8 bits (151), Expect = 2e-09
Identities = 47/157 (29%), Positives = 75/157 (47%), Gaps = 17/157 (10%)
Query: 623 DNEDGFEEEEEEEEEMTDESEEDGEEKVEKEEKEEELEEEEEKEEEEEEEGNQETAEFLL 682
++E+ E + EEEEE+ +E E+D E+ + E++EEE EEEEE+EEEEE E +Q +
Sbjct: 120 EDEEDEEGDREEEEEIEEEDEDDDEDGEDVEDEEEEEEEEEEEEEEEENEDHQ------M 173
Query: 683 SSEEIETKDEKEMDKENNDGSSEIGKAV--GFLSVPKSLSSDSTLLLFKDSSSKMGYFPT 740
+ + E D NND + V L++ K + + +
Sbjct: 174 NCHNTRIMQDTEKDDNNNDEYDNYDELVAKSLLNLGKIAEDAAYRARTESEMNSNTSNSL 233
Query: 741 EEKSETDENSGKQPS---KLDED------DSCSLLTK 768
E+ S+ +EN G++ LD D DS LL +
Sbjct: 234 EDDSDKNENLGRKSELSLDLDSDVVRETVDSLKLLAQ 270
Score = 45.8 bits (107), Expect = 3e-04
Identities = 52/232 (22%), Positives = 93/232 (40%), Gaps = 33/232 (14%)
Query: 945 SGKFTSQDA--STPASSELNKQEKESSMGDPMEEALALCSGSFPTDKEEEDEEEEFGDFR 1002
SGK+ + P + + Q+K+ P + A+ + S D+ ++ + E D +
Sbjct: 43 SGKYARHRSVYGCPLAKKRKTQDKQPQEPAPKRKPFAVKADSSSVDECDDSDGTEDMDEK 102
Query: 1003 LVSNDNEFDSDEDEHSDSGNDLALEDHEDDDEEELLKRSEKLKRQMRLRKYLEDEAEVSG 1062
E+ D DE D ED E D EEE E+++ + +++ + G
Sbjct: 103 EEDEGEEYSEDNDEPGDEDE----EDEEGDREEE-----EEIEEE-------DEDDDEDG 146
Query: 1063 SDVGSEDEYDGEEIDEYEEDVIDEVLPSDEELQSQIKKIHMKTMLDDDKRQL-----RLY 1117
DV E+E + EE +E EE+ + D ++ +I T DD+ L
Sbjct: 147 EDVEDEEEEEEEEEEEEEEEENE-----DHQMNCHNTRIMQDTEKDDNNNDEYDNYDELV 201
Query: 1118 QERYLADGDLHSDGPGRMRKFRWKNIDDASQMDLFHRDSDDDQTEEQLDESE 1169
+ L G + D R R N + ++ + + D D+ E +SE
Sbjct: 202 AKSLLNLGKIAEDAAYRARTESEMNSNTSNSL-----EDDSDKNENLGRKSE 248
Score = 32.7 bits (73), Expect = 2.4
Identities = 31/147 (21%), Positives = 57/147 (38%), Gaps = 17/147 (11%)
Query: 22 EEADSPSDSGQGSYETIGPLSEGDSDEEIFVSKKLKNRKVLQDSDSETEDTNASPEKTTY 81
E+ D P D + EGD +EE + ++ +D D + ED E+
Sbjct: 112 EDNDEPGDEDEED-------EEGDREEEEEIEEED------EDDDEDGEDVEDEEEEEEE 158
Query: 82 DSAEEENKENLYAGKNTKIKRIYKTVADSDESYMEKSLYQENLEAQV----KPCLELSLQ 137
+ EEE +EN N RI + D + E Y E + + K + + +
Sbjct: 159 EEEEEEEEENEDHQMNCHNTRIMQDTEKDDNNNDEYDNYDELVAKSLLNLGKIAEDAAYR 218
Query: 138 SGNSTDFTTDRKSSKKHIHDKEGTAGK 164
+ ++ ++ +S + DK G+
Sbjct: 219 ARTESEMNSNTSNSLEDDSDKNENLGR 245
Score = 31.6 bits (70), Expect = 5.3
Identities = 39/167 (23%), Positives = 66/167 (39%), Gaps = 19/167 (11%)
Query: 931 SDKKENMEELLNLCSGKFTSQDASTPASSELN--------KQEKESSMGDPMEEALALCS 982
SD E+M+E G+ S+D P + ++E E D E+ +
Sbjct: 93 SDGTEDMDEKEE-DEGEEYSEDNDEPGDEDEEDEEGDREEEEEIEEEDEDDDEDGEDVED 151
Query: 983 GSFPTDKEEEDEEEEFGDFRLVSNDNEFDSDEDEHSDSGNDLALEDHEDDDEEELLKRS- 1041
++EEE+EEEE + ++ N + E D+ ND E D+ +EL+ +S
Sbjct: 152 EEEEEEEEEEEEEEEENEDHQMNCHNTRIMQDTEKDDNNND------EYDNYDELVAKSL 205
Query: 1042 ---EKLKRQMRLRKYLEDEAEVSGSDVGSEDEYDGEEIDEYEEDVID 1085
K+ R E E + S+ +D E + E +D
Sbjct: 206 LNLGKIAEDAAYRARTESEMNSNTSNSLEDDSDKNENLGRKSELSLD 252
>gi|94536805 splicing factor YT521-B isoform 2 [Homo sapiens]
Length = 709
Score = 69.7 bits (169), Expect = 2e-11
Identities = 51/157 (32%), Positives = 78/157 (49%), Gaps = 12/157 (7%)
Query: 623 DNEDGFEEEEEEEEEMTDESEEDGEEKVEKEEKEEELEEEEEKEEEEEEEGNQETAEFLL 682
+ E+G EE+ EE+EE+ +++EED E + EE+EEE EEEEE+EEEEEEE Q+ +
Sbjct: 200 NEEEGVEEDVEEDEEVEEDAEEDEEVDEDGEEEEEEEEEEEEEEEEEEEEYEQDERDQKE 259
Query: 683 SSEEIETKDEKEMDKENNDGSSEIGKAVGFLSVPKSLSSDSTLLLFKDSSSKMGYFP--- 739
+ +T+ E ++ GS + G SV +D + K+ G P
Sbjct: 260 EGNDYDTRSE-----ASDSGSESVSFTDG--SVRSGSGTDGSDEKKKERKRARGISPIVF 312
Query: 740 TEEKSETDENSGKQPSKLDE--DDSCSLLTKESSHNS 774
S E+ Q SKL D+ L K ++H +
Sbjct: 313 DRSGSSASESYADQTSKLKYVLQDARFFLIKSNNHEN 349
Score = 63.2 bits (152), Expect = 2e-09
Identities = 76/272 (27%), Positives = 114/272 (41%), Gaps = 28/272 (10%)
Query: 622 LDNEDGFEEEEEEEEEMTDESEEDGEEKVEKEEKEEELEEE-EEKEEEEEEEGNQETAEF 680
++ ++ EE+ EE+EE+ ++ EE+ EE+ E+EE+EEE EEE E+ E +++EEGN
Sbjct: 209 VEEDEEVEEDAEEDEEVDEDGEEEEEEEEEEEEEEEEEEEEYEQDERDQKEEGNDYDTRS 268
Query: 681 LLS---SEEIETKDEKEMDKENNDGSSEIGK----AVGFLSVPKSLSSDSTLLLFKDSSS 733
S SE + D DGS E K A G + S S + D +S
Sbjct: 269 EASDSGSESVSFTDGSVRSGSGTDGSDEKKKERKRARGISPIVFDRSGSSASESYADQTS 328
Query: 734 KMGYFPTEE-----KSETDENSGKQPSKLDEDDSCSLLTKESSHNSSFELIGSTIPSYQP 788
K+ Y + KS EN +K +L E N +F S I +
Sbjct: 329 KLKYVLQDARFFLIKSNNHENVSLAKAK---GVWSTLPVNEKKLNLAFRSARSVILIFSV 385
Query: 789 CNRQTGRGTSFFPTA-----GGFRSPSPGLFRASLVSSASKSSGKLS---EPSLPIEDSQ 840
R++G+ F + GG SP + A + + K+ LP S
Sbjct: 386 --RESGKFQGFARLSSESHHGG--SPIHWVLPAGMSAKMLGGVFKIDWICRRELPFTKSA 441
Query: 841 DLYNASPEPKTLFLGAGDFQFCLEDDTQSQLL 872
L N E K + +G + LE TQ LL
Sbjct: 442 HLTNPWNEHKPVKIGRDGQEIELECGTQLCLL 473
Score = 47.8 bits (112), Expect = 7e-05
Identities = 37/161 (22%), Positives = 74/161 (45%), Gaps = 3/161 (1%)
Query: 605 MKLRRFEERQKRQALFKLDNEDGFEEEEEEEEEMTDESEEDGEEKVEKEEKEEELEEEEE 664
+++ R R + + ++++E+ + E +DE + E + E E++ E +EE E
Sbjct: 157 LEVDRRASRSSQSSKEEVNSEEYGSDHETGSSGSSDEQGNNTENEEEGVEEDVEEDEEVE 216
Query: 665 KEEEEEEEGNQETAEFLLSSEEIETKDEKEMDKENNDGSSEIGKAVGFLSVPKSLSSDST 724
++ EE+EE +++ E EE E ++E+E ++ D + + + + ++ S S
Sbjct: 217 EDAEEDEEVDEDGEEEEEEEEEEEEEEEEEEEEYEQDERDQKEEGNDYDTRSEASDSGSE 276
Query: 725 LLLFKDSSSKMGY---FPTEEKSETDENSGKQPSKLDEDDS 762
+ F D S + G E+K E G P D S
Sbjct: 277 SVSFTDGSVRSGSGTDGSDEKKKERKRARGISPIVFDRSGS 317
Score = 38.5 bits (88), Expect = 0.044
Identities = 52/236 (22%), Positives = 91/236 (38%), Gaps = 46/236 (19%)
Query: 226 PLEDEESLESIRAAVKNKVKKHKKKEPSLES--------GVHSFEEGSE-LSKGTTRKER 276
P +D+E KN+ K K+K +ES VHS + S+ LS + +R
Sbjct: 24 PEQDDELYNPESEQDKNEKKGSKRKSDRMESTDTKRQKPSVHSRQLVSKPLSSSVSNNKR 83
Query: 277 KAARLSKEALKQLHSETQRLIRESALNL-------------PYHMPENKTI---HDFFKR 320
+ K A + + E QR R L+ PY KT D +R
Sbjct: 84 IVSTKGKSATEYKNEEYQRSERNKRLDADRKIRLSSSASREPYKNQPEKTCVRKRDPERR 143
Query: 321 KPRPTCHGNAMALLK-----------------SSKYQSSHHKEIIDTANTTEMNSDHHSK 363
PT G+ L+ S +Y S H +++ N+++ +
Sbjct: 144 AKSPTPDGSERIGLEVDRRASRSSQSSKEEVNSEEYGSDHETGSSGSSDEQGNNTENEEE 203
Query: 364 GSEQTTGAENEVETNALPVVSKETQIITGSDESCRKDLVKNEELEIQEKQKQSDIR 419
G E+ + EVE +A ++ ++ +E ++ + EE E +E++ + D R
Sbjct: 204 GVEEDVEEDEEVEEDA----EEDEEVDEDGEEEEEEEEEEEEEEEEEEEEYEQDER 255
Score = 38.5 bits (88), Expect = 0.044
Identities = 21/83 (25%), Positives = 44/83 (53%), Gaps = 2/83 (2%)
Query: 1006 NDNEFDSDEDEHSDSGNDLALEDHEDDDE--EELLKRSEKLKRQMRLRKYLEDEAEVSGS 1063
N E+ SD + S +D + E+++E EE ++ E+++ + ++++ E
Sbjct: 175 NSEEYGSDHETGSSGSSDEQGNNTENEEEGVEEDVEEDEEVEEDAEEDEEVDEDGEEEEE 234
Query: 1064 DVGSEDEYDGEEIDEYEEDVIDE 1086
+ E+E + EE +EYE+D D+
Sbjct: 235 EEEEEEEEEEEEEEEYEQDERDQ 257
Score = 37.0 bits (84), Expect = 0.13
Identities = 40/153 (26%), Positives = 65/153 (42%), Gaps = 9/153 (5%)
Query: 919 FTSQAEKHLPRKSDKKENMEELLNLCSGKFTSQ-DASTPASSELNKQEKESSMGDPMEEA 977
+ +Q EK RK D + + S + + D SS+ +K+E S E
Sbjct: 126 YKNQPEKTCVRKRDPERRAKSPTPDGSERIGLEVDRRASRSSQSSKEEVNSEEYGSDHET 185
Query: 978 LALCSGSFP-----TDKEEEDEEEEFGDFRLVSNDNEFDSDEDEHSDSGNDLALEDHEDD 1032
+ SGS T+ EEE EE+ + V D E D + DE + + E+ E++
Sbjct: 186 GS--SGSSDEQGNNTENEEEGVEEDVEEDEEVEEDAEEDEEVDEDGEEEEEEEEEEEEEE 243
Query: 1033 DEEELLKRSEKLKRQMRLRKY-LEDEAEVSGSD 1064
+EEE ++ ++ Y EA SGS+
Sbjct: 244 EEEEEEYEQDERDQKEEGNDYDTRSEASDSGSE 276
Score = 35.8 bits (81), Expect = 0.28
Identities = 36/157 (22%), Positives = 67/157 (42%), Gaps = 16/157 (10%)
Query: 132 LELSLQSGNSTDFTTDRKSSKKHIHDKEGTAGKAKVKSKRRLEKEERKMEKIRQLKKKET 191
LE+ ++ S+ + + +S+++ D E + + + E EE +E E
Sbjct: 157 LEVDRRASRSSQSSKEEVNSEEYGSDHETGSSGSSDEQGNNTENEEEGVE--------ED 208
Query: 192 KNQEDDVEQPFNDSGCLLVDKDLFETGLEDENNSPLEDEESLESIRAAVKNKVKKHKKKE 251
++++VE+ + + D + E E+E E+EE E K + + +
Sbjct: 209 VEEDEEVEEDAEEDEEVDEDGEEEEEEEEEEEEEEEEEEEEYEQDERDQKEEGNDYDTRS 268
Query: 252 PSLESGVH--SFEEGSELSKGTT------RKERKAAR 280
+ +SG SF +GS S T +KERK AR
Sbjct: 269 EASDSGSESVSFTDGSVRSGSGTDGSDEKKKERKRAR 305
Score = 33.9 bits (76), Expect = 1.1
Identities = 32/152 (21%), Positives = 68/152 (44%), Gaps = 7/152 (4%)
Query: 5 VGSEVHLEINDPNVISQEEADSP---SDSGQGSYETIGPLSEGDSDEEIFVSKKLKNRKV 61
+G EV + + S+EE +S SD GS + +EE V + ++ +
Sbjct: 155 IGLEVDRRASRSSQSSKEEVNSEEYGSDHETGSSGSSDEQGNNTENEEEGVEEDVEEDEE 214
Query: 62 LQDSDSETEDTNASPEKTTYDSAEEENKENLYAGKNTKIKRIYKTVADSDESYMEKSLYQ 121
+++ E E+ + E+ + EEE +E + + +R K + ++ E S
Sbjct: 215 VEEDAEEDEEVDEDGEEEEEEEEEEEEEEEEEEEEYEQDERDQKEEGNDYDTRSEAS--- 271
Query: 122 ENLEAQVKPCLELSLQSGNSTDFTTDRKSSKK 153
+ ++ + S++SG+ TD + ++K +K
Sbjct: 272 -DSGSESVSFTDGSVRSGSGTDGSDEKKKERK 302
>gi|155030232 proline, glutamic acid and leucine rich protein 1
[Homo sapiens]
Length = 1130
Score = 69.3 bits (168), Expect = 2e-11
Identities = 43/94 (45%), Positives = 57/94 (60%), Gaps = 4/94 (4%)
Query: 619 LFKLDNEDGFEEEEEEEEEMTDESEEDGEEKVEKEEKEEELEEEEEKEEEE-EEEGNQET 677
+ +++ D EEEEEEEEE +E EE+ E+ E+EE EEE EEEE+EEEE EEE +E
Sbjct: 880 VININSSDEEEEEEEEEEEEEEEEEEEEEDFEEEEEDEEEYFEEEEEEEEEFEEEFEEEE 939
Query: 678 AEFLLSSEEIETKDEKEMDKENNDGSSEIGKAVG 711
E EE E +DE+E ++ E G A G
Sbjct: 940 GEL---EEEEEEEDEEEEEELEEVEDLEFGTAGG 970
Score = 67.8 bits (164), Expect = 7e-11
Identities = 48/124 (38%), Positives = 65/124 (52%), Gaps = 11/124 (8%)
Query: 574 PVTLAPKKL------DGASHTKPGEKLQVLKAKLQEAMKLRRFEERQKRQALFKLDNEDG 627
PVTL P +L G E L V+ + + EE ++ + + + E+
Sbjct: 852 PVTLPPPQLVPEGTPGGGGPPALEEDLTVININSSDEEEEEEEEEEEEEEE--EEEEEED 909
Query: 628 FEEEEEEEEEMTDESEEDGEE---KVEKEEKEEELEEEEEKEEEEEEEGNQETAEFLLSS 684
FEEEEE+EEE +E EE+ EE + E+EE E E EEEEE EEEEEE E EF +
Sbjct: 910 FEEEEEDEEEYFEEEEEEEEEFEEEFEEEEGELEEEEEEEDEEEEEELEEVEDLEFGTAG 969
Query: 685 EEIE 688
E+E
Sbjct: 970 GEVE 973
Score = 55.5 bits (132), Expect = 3e-07
Identities = 28/71 (39%), Positives = 45/71 (63%)
Query: 635 EEEMTDESEEDGEEKVEKEEKEEELEEEEEKEEEEEEEGNQETAEFLLSSEEIETKDEKE 694
EE++T + +E+ E+EE+EEE EEEEE+EEE+ EE ++ E+ EE E + E+E
Sbjct: 875 EEDLTVININSSDEEEEEEEEEEEEEEEEEEEEEDFEEEEEDEEEYFEEEEEEEEEFEEE 934
Query: 695 MDKENNDGSSE 705
++E + E
Sbjct: 935 FEEEEGELEEE 945
Score = 53.5 bits (127), Expect = 1e-06
Identities = 33/83 (39%), Positives = 48/83 (57%), Gaps = 6/83 (7%)
Query: 630 EEEEEEEEMTDESEEDGEEKVEKEEKEEELEEEEEKEEEEE------EEGNQETAEFLLS 683
EE+ + EE+ EE+ E+EE+EEE EEEE+ EEEEE EE +E EF
Sbjct: 875 EEDLTVININSSDEEEEEEEEEEEEEEEEEEEEEDFEEEEEDEEEYFEEEEEEEEEFEEE 934
Query: 684 SEEIETKDEKEMDKENNDGSSEI 706
EE E + E+E ++E+ + E+
Sbjct: 935 FEEEEGELEEEEEEEDEEEEEEL 957
Score = 44.3 bits (103), Expect = 8e-04
Identities = 72/307 (23%), Positives = 112/307 (36%), Gaps = 71/307 (23%)
Query: 390 ITGSDESCRKDLVKNEELEIQEKQKQSDIRPSPGDSSVLQQESNFLGNNHSEECQVGGLV 449
I SDE ++ + EE E +E++++ D D E + EE +
Sbjct: 883 INSSDEE-EEEEEEEEEEEEEEEEEEEDFEEEEED------EEEYFEEEEEEEEEFEEEF 935
Query: 450 AFEPHALEGEGPQNPEETDEKVEEPEQQNKSSAVGPPEKVRRFTLDRLKQLGVDVSIKPR 509
E LE E + EE +E++EE E +A G E+ P
Sbjct: 936 EEEEGELEEEEEEEDEEEEEELEEVEDLEFGTAGGEVEE--------------GAPPPPT 981
Query: 510 LGADEDSFVILEPETNRELEALKQRFWKHANPAAKPRAGQTVNVNVIVKDMGTDGKEELK 569
L + PE+ +++ P +P G + V ++ GT+ EE
Sbjct: 982 LPP-----ALPPPESPPKVQ-----------PEPEPEPGLLLEV----EEPGTE--EERG 1019
Query: 570 ADVVPVTLAPKKLDGASHTKPGEKLQVLKAKLQEAMKLRRFEERQKRQALFKLDNEDGFE 629
AD P TLAP+ L ER+ ++ E
Sbjct: 1020 ADTAP-TLAPEALPSQGEV-----------------------EREGESPAAGPPPQELVE 1055
Query: 630 EEEEEEEEMTDESEEDGEEKVE---KEEKEEELEEEEEKEEEEEEEGNQETAEFLLSSEE 686
EE + +E EDG +KV+ + EEE+E E E E +E+E +TA L +
Sbjct: 1056 EEPSAPPTLLEEETEDGSDKVQPPPETPAEEEMETETEAEALQEKE-QDDTAAMLADFID 1114
Query: 687 IETKDEK 693
DEK
Sbjct: 1115 CPPDDEK 1121
Score = 43.5 bits (101), Expect = 0.001
Identities = 30/108 (27%), Positives = 56/108 (51%), Gaps = 19/108 (17%)
Query: 974 MEEALALCSGSFPTDKEEEDEEEEFGDFRLVSNDNEFDSDEDEHSDSGNDLALEDHEDDD 1033
+EE L + + + ++EEE+EEEE E + +E+E D + E++D
Sbjct: 874 LEEDLTVININSSDEEEEEEEEEE----------EEEEEEEEEEEDF-------EEEEED 916
Query: 1034 EEELLKRSEKLKRQMRLRKYLEDEAEVSGSDVGSEDEYDGEEIDEYEE 1081
EEE + E+ + + ++ E+E E+ + EDE + EE++E E+
Sbjct: 917 EEEYFEEEEEEEEEFE-EEFEEEEGELE-EEEEEEDEEEEEELEEVED 962
Score = 42.7 bits (99), Expect = 0.002
Identities = 39/142 (27%), Positives = 67/142 (47%), Gaps = 10/142 (7%)
Query: 561 GTDGKEELKADVVPVTLAPKKLDGASHTKPGEKLQVLKAKLQEAMKLRRFEERQKRQALF 620
G G L+ D+ + + +S + E+ + + + +E + FEE ++ + +
Sbjct: 867 GGGGPPALEEDLTVINI------NSSDEEEEEEEEEEEEEEEEEEEEEDFEEEEEDEEEY 920
Query: 621 ---KLDNEDGFEEE-EEEEEEMTDESEEDGEEKVEKEEKEEELEEEEEKEEEEEEEGNQE 676
+ + E+ FEEE EEEE E+ +E EE+ EE+ E+ E+ E+LE E EE
Sbjct: 921 FEEEEEEEEEFEEEFEEEEGELEEEEEEEDEEEEEELEEVEDLEFGTAGGEVEEGAPPPP 980
Query: 677 TAEFLLSSEEIETKDEKEMDKE 698
T L E K + E + E
Sbjct: 981 TLPPALPPPESPPKVQPEPEPE 1002
Score = 42.4 bits (98), Expect = 0.003
Identities = 30/101 (29%), Positives = 52/101 (51%), Gaps = 26/101 (25%)
Query: 987 TDKEEEDEEEEFGDFRLVSNDNEFDSDEDEHSDSGNDLALEDHEDDDEEELLKRSEKLKR 1046
+D+EEE+EEEE + E + +E+E D + E++DEEE + E+ +
Sbjct: 886 SDEEEEEEEEE---------EEEEEEEEEEEEDF-------EEEEEDEEEYFEEEEEEEE 929
Query: 1047 QMRLRKYLEDEAEVSGSDVGSEDEYDGEEIDEYEEDVIDEV 1087
+ ++ E+E E+ E + EE DE EE+ ++EV
Sbjct: 930 EFE-EEFEEEEGEL---------EEEEEEEDEEEEEELEEV 960
Score = 40.8 bits (94), Expect = 0.009
Identities = 25/91 (27%), Positives = 45/91 (49%), Gaps = 3/91 (3%)
Query: 995 EEEFGDFRLVSNDNEFDSDEDEHSDSGNDLALEDHEDDDEEELLKRSEKLKRQMRLRKYL 1054
EE+ + S+D E + +E+E + + E+ E+D EEE E + + +
Sbjct: 875 EEDLTVININSSDEEEEEEEEEEEEEEEE---EEEEEDFEEEEEDEEEYFEEEEEEEEEF 931
Query: 1055 EDEAEVSGSDVGSEDEYDGEEIDEYEEDVID 1085
E+E E ++ E+E + EE +E E+V D
Sbjct: 932 EEEFEEEEGELEEEEEEEDEEEEEELEEVED 962
Score = 38.5 bits (88), Expect = 0.044
Identities = 22/54 (40%), Positives = 30/54 (55%)
Query: 660 EEEEEKEEEEEEEGNQETAEFLLSSEEIETKDEKEMDKENNDGSSEIGKAVGFL 713
EEEEE+EEEEEEE +E E EE E + +E ++E + E + G L
Sbjct: 889 EEEEEEEEEEEEEEEEEEEEDFEEEEEDEEEYFEEEEEEEEEFEEEFEEEEGEL 942
Score = 37.7 bits (86), Expect = 0.075
Identities = 24/68 (35%), Positives = 36/68 (52%), Gaps = 10/68 (14%)
Query: 988 DKEEEDEEEEFGDFRLVSNDNE--FDSDEDE--------HSDSGNDLALEDHEDDDEEEL 1037
++EEE+EEEE DF D E F+ +E+E + G E+ ED++EEE
Sbjct: 897 EEEEEEEEEEEEDFEEEEEDEEEYFEEEEEEEEEFEEEFEEEEGELEEEEEEEDEEEEEE 956
Query: 1038 LKRSEKLK 1045
L+ E L+
Sbjct: 957 LEEVEDLE 964
Score = 37.4 bits (85), Expect = 0.097
Identities = 26/98 (26%), Positives = 49/98 (50%), Gaps = 17/98 (17%)
Query: 1004 VSNDNEFDSDEDEHSDSGNDLALEDHEDDDEEELLKRSEKLKRQMRLRKYLEDEAEVSGS 1063
V N N D +E+E E+ E+++EEE + E + + EDE E
Sbjct: 880 VININSSDEEEEE----------EEEEEEEEEEEEEEEEDFEEEE------EDEEEYFEE 923
Query: 1064 DVGSEDEYDGEEIDEYEEDVIDEVLPSDEELQSQIKKI 1101
+ E+E++ EE +E E ++ +E DEE + +++++
Sbjct: 924 EEEEEEEFE-EEFEEEEGELEEEEEEEDEEEEEELEEV 960
>gi|20336205 transcriptional regulator ATRX isoform 2 [Homo sapiens]
Length = 2454
Score = 69.3 bits (168), Expect = 2e-11
Identities = 144/779 (18%), Positives = 304/779 (39%), Gaps = 104/779 (13%)
Query: 45 DSDEEIFVSKKLKNRKVLQDSDSETEDTNASPEKTTYDSAEEENKEN------------- 91
DSDE + + K++ SD++ + + + KT YD + K++
Sbjct: 692 DSDEMLAILKEVSRMSHSSSSDTDINEIHTN-HKTLYDLKTQAGKDDKGKRKRKSSTSGS 750
Query: 92 ---LYAGKNTKIKRIYKTVADSDESYMEKSLYQENLEAQVKPCLELSL------QSGNST 142
GK+ K I K ++ E S Y LE ++K ++ + N+
Sbjct: 751 DFDTKKGKSAKSSIISKK---KRQTQSESSNYDSELEKEIKSMSKIGAARTTKKRIPNTK 807
Query: 143 DFTT--DRKSSKKHIHDK---------EGTAGKAKVKSKRR--------LEKEERKMEKI 183
DF + D K SKK + ++ EG++ A+ K +R ++K+ ME
Sbjct: 808 DFDSSEDEKHSKKGMDNQGHKNLKTSQEGSSDDAERKQERETFSSAEGTVDKDTTIMELR 867
Query: 184 RQLKKKETKNQEDDVEQPFNDSGCLLVDKDLFETGLEDENNSPLEDEESLESIRAAVKNK 243
+L KK+ + D + ++ + E + L+ + + + ++ + +
Sbjct: 868 DRLPKKQQASASTDGVDKLSGKEQSFTSLEVRKVAETKEKSKHLKTK-TCKKVQDGLSDI 926
Query: 244 VKKHKKKEPSLESGVHSFEEGSELSKGTTRKERKAARLSKEALKQLHSETQRLIRESALN 303
+K KK+ S E+ E+ + SK T +++K + K+ +K E Q ES+ +
Sbjct: 927 AEKFLKKDQSDETS----EDDKKQSKKGTEEKKKPSDFKKKVIKM---EQQY---ESSSD 976
Query: 304 LPYHMPENKTIHDFFKRKPRPTCHGNAMALLKSSKYQSSHHKEIIDTANTTEMNSDHHSK 363
+PE + I F K + +G KS K + K+ + ++ E ++ K
Sbjct: 977 GTEKLPEREEICHFPKGI-KQIKNGTTDGEKKSKKIRDKTSKKKDELSDYAEKST---GK 1032
Query: 364 GSEQTTGAENEVETNALPVVSKETQIITGSDESCRKDLVKNEELEIQEKQKQSDIRPSPG 423
G + + + + A K +++ G R+D ++ + K+ +
Sbjct: 1033 GDSCDSSEDKKSKNGAYGREKKRCKLL-GKSSRKRQDCSSSDTEKYSMKEDGCNSSDKRL 1091
Query: 424 DSSVLQQESNFLGNNHSEECQVGGLVAFEPHALEGEGPQNPEETDEKVEEPEQQNKSSAV 483
L++ N +++E Q G + + ++ E+ +K + + K+ V
Sbjct: 1092 KRIELRERRNLSSKRNTKEIQSG--------SSSSDAEESSEDNKKKKQRTSSKKKAVIV 1143
Query: 484 GPPEKVRRFTLDRLKQLGVDVSIKPRLGADEDSFVILEPETNRELEALKQRFWKHANPAA 543
++ T + KQ + S + D+ + + ++++ + + ++
Sbjct: 1144 KEKKRNSLRTSTKRKQADITSSSSSDIEDDDQNSIGEGSSDEQKIKPVTENLVLSSHTGF 1203
Query: 544 KPRAGQTV---NVNVIVKDMGTDGKEE------LKADVVPVTLAPKKLDGASHTKPGEKL 594
+G +V V V D D E + + + L+ + DG+S +P E
Sbjct: 1204 CQSSGDEALSKSVPVTVDDDDDDNDPENRIAKKMLLEEIKANLSSDE-DGSSDDEPEEG- 1261
Query: 595 QVLKAKLQEAMKLRRFEERQKRQALFKLDNEDGFEEEEEEE---------EEMTDESEED 645
K + + + +E K Q +++E + EE ++ ++T E
Sbjct: 1262 ---KKRTGKQNEENPGDEEAKNQ----VNSESDSDSEESKKPRYRHRLLRHKLTVSDGES 1314
Query: 646 GEEKVEKEEKEEELEEEEEKEEEEEEEGNQETAEFLLSSEEIETKDE--------KEMDK 697
GEEK K ++ +E++ ++ E+ + + E +S E E++DE K+ +
Sbjct: 1315 GEEKKTKPKEHKEVKGRNRRKVSSEDSEDSDFQESGVSEEVSESEDEQRPRTRSAKKAEL 1374
Query: 698 ENNDGSSEIGKAVGFLSVPKSLSSDSTLLLFKDSSSKMGYFPTEEKSETDENSGKQPSK 756
E N S + K + V + SS++ ++ K EE+ E +E SK
Sbjct: 1375 EENQRSYKQKKKRRRIKVQEDSSSENKSNSEEEEEEKEEEEEEEEEEEEEEEDENDDSK 1433
Score = 68.2 bits (165), Expect = 5e-11
Identities = 149/743 (20%), Positives = 270/743 (36%), Gaps = 136/743 (18%)
Query: 57 KNRKVLQDSDSETEDTNASPEKTTYDSAEEENKENLY---AGKNTKIKRIYKTVADSDES 113
K K + S + E + YDS E+ +++ A + TK KRI T D D S
Sbjct: 755 KKGKSAKSSIISKKKRQTQSESSNYDSELEKEIKSMSKIGAARTTK-KRIPNT-KDFDSS 812
Query: 114 YMEKSLYQENLEAQVKPCLELSLQSGNSTDFTTDRKSSKKHIHDKEGTAGK--------- 164
EK ++ ++ Q L+ S Q G+S D +RK ++ EGT K
Sbjct: 813 EDEKHS-KKGMDNQGHKNLKTS-QEGSSDD--AERKQERETFSSAEGTVDKDTTIMELRD 868
Query: 165 ---------AKVKSKRRLEKEERKMEKIRQLKKKETKNQEDDVEQPFNDSGCLLVD---K 212
A +L +E+ + K ETK + ++ C V
Sbjct: 869 RLPKKQQASASTDGVDKLSGKEQSFTSLEVRKVAETKEKSKHLKT----KTCKKVQDGLS 924
Query: 213 DLFETGLE-DENNSPLEDEESLESIRAAVKNKVKKHKKKEPSLESGVHSFEEGSE----- 266
D+ E L+ D+++ ED++ K K KKK +E S +G+E
Sbjct: 925 DIAEKFLKKDQSDETSEDDKKQSKKGTEEKKKPSDFKKKVIKMEQQYESSSDGTEKLPER 984
Query: 267 ------------LSKGTTRKERKAARLSKEALKQLHSETQRLIRESALNLPYHMPENKTI 314
+ GTT E+K+ ++ + K+ + + + E+K
Sbjct: 985 EEICHFPKGIKQIKNGTTDGEKKSKKIRDKTSKKKDELSDYAEKSTGKGDSCDSSEDKKS 1044
Query: 315 HDFFKRKPRPTCHGNAMALLKSSKYQSSHHK-------------------EIIDTANTTE 355
+ + + C + K SS + E+ + N +
Sbjct: 1045 KNGAYGREKKRCKLLGKSSRKRQDCSSSDTEKYSMKEDGCNSSDKRLKRIELRERRNLSS 1104
Query: 356 MNSDHHSKGSEQTTGAENEVETNALPVVSKETQIITGSDESCRKDLVKNEELEIQEKQKQ 415
+ + ++ AE E N K+ Q + ++ K L K+KQ
Sbjct: 1105 KRNTKEIQSGSSSSDAEESSEDN-----KKKKQRTSSKKKAVIVKEKKRNSLRTSTKRKQ 1159
Query: 416 SDIRPSPGDSSVLQQESNFLGNNHSEECQVGGLVAFEPHALEGEGPQNPEETDEKVEE-- 473
+DI S S + + N +G S+E ++ + E L DE + +
Sbjct: 1160 ADITSS-SSSDIEDDDQNSIGEGSSDEQKIKPVT--ENLVLSSHTGFCQSSGDEALSKSV 1216
Query: 474 PEQQNKSSAVGPPEKVRRFTLDRLKQLGVDVSIKPRLGADEDSFVILEPETNRELEALKQ 533
P + PE +R+ + + IK L +DED EPE +
Sbjct: 1217 PVTVDDDDDDNDPE-------NRIAKKMLLEEIKANLSSDEDGSSDDEPEEGK------- 1262
Query: 534 RFWKHANPAAKPRAGQTVNVNVIVKDMGTDGKEELKADVVPVTLAPKKL--DGAS----H 587
K + G N + + +D +E K L K DG S
Sbjct: 1263 ---KRTGKQNEENPGDEEAKNQVNSESDSDSEESKKPRYRHRLLRHKLTVSDGESGEEKK 1319
Query: 588 TKPGEKLQVL------------------KAKLQEAMKLRRFEERQKRQALFKLDNEDGFE 629
TKP E +V ++ + E + E+R + ++ K + E+
Sbjct: 1320 TKPKEHKEVKGRNRRKVSSEDSEDSDFQESGVSEEVSESEDEQRPRTRSAKKAELEENQR 1379
Query: 630 EEEEEEE----EMTDESEEDGEEKVEKEEKEEELEEEEEKEEEEEEEGNQETAEF----- 680
+++++ ++ ++S + + E+EE+E+E EEEEE+EEEEEEE + ++
Sbjct: 1380 SYKQKKKRRRIKVQEDSSSENKSNSEEEEEEKEEEEEEEEEEEEEEEDENDDSKSPGKGR 1439
Query: 681 -----LLSSEEIETKDEKEMDKE 698
+L +++ T+ + + +E
Sbjct: 1440 KKIRKILKDDKLRTETQNALKEE 1462
Score = 65.9 bits (159), Expect = 3e-10
Identities = 225/1262 (17%), Positives = 448/1262 (35%), Gaps = 218/1262 (17%)
Query: 87 ENKENLYAGKNTKIKRIYKTVADSDESYMEKSLYQENLEAQVKPCLELSLQSGNSTDFTT 146
+N E A K ++K +AD ++++ +E+L ++ + ++ +
Sbjct: 341 DNSEISSATKLRQLKAFKSVLADIKKAHLA---LEEDLNSEFRAMDAVNKEKNTKEHKVI 397
Query: 147 DRKSS-------------KKHIHDKEGTAGKAKVKSK---RRLEKEERKMEKIRQLKKKE 190
D K KK I E + +V S+ + + EE++ K + K+
Sbjct: 398 DAKFETKARKGEKPCALEKKDISKSEAKLSRKQVDSEHMHQNVPTEEQRTNKSTGGEHKK 457
Query: 191 TKNQEDDVEQPFNDSGCLLVDKDLFETGLEDENNSPLEDEESLESIRAAVKNKVKKHKKK 250
+ +E+ +P N S L D D+ ++ P + E+LE+ +V+
Sbjct: 458 SDRKEEPQYEPANTSEDL--DMDIVSV----PSSVPEDIFENLETAM-----EVQSSVDH 506
Query: 251 EPSLESGVHSFEEGSELSKGTTRKERKAARLSKEALKQLHSETQRLIRESALNLPY---- 306
+ SG E S + + K+ + SK K +L S N P
Sbjct: 507 QGDGSSGTEQEVESSSVKLNISSKDNRGGIKSKTTAKVTKELYVKLTPVSLSNSPIKGAD 566
Query: 307 --HMPENKTIHDFFKRKPRPTCHGNAMALLKSSKYQSSHHKEIIDTANTTEMN-SDHHSK 363
+P++K D +K +C N ++S ++ +++ + + SD
Sbjct: 567 CQEVPQDK---DGYK-----SCGLNPKLEKCGLGQENSDNEHLVENEVSLLLEESDLRRS 618
Query: 364 GSEQTTGAENEVETNALPVVSKETQIITGSDESCRKDLVKNEELEIQEKQKQSDIRPSPG 423
+TT ETN PV S SDE C + + + ++L + ++K + +
Sbjct: 619 PRVKTTPLRRPTETN--PVTSN-------SDEECNETVKEKQKLSVPVRKKD---KRNSS 666
Query: 424 DSSVLQQESNFLGNNHSEECQVGGLVAFEPHAL--EGEGPQNPEETDEKVEEPEQQNKS- 480
DS++ + N L + E + E A+ E + +D + E +K+
Sbjct: 667 DSAIDNPKPNKLPKSKQSETVDQNSDSDEMLAILKEVSRMSHSSSSDTDINEIHTNHKTL 726
Query: 481 ----SAVGPPEKVRRFTLDRLKQLGVDVSIKPRLGADEDSFVILEPETNRELEALKQRFW 536
+ G +K +R + G D K A + +T E
Sbjct: 727 YDLKTQAGKDDKGKRKR--KSSTSGSDFDTKKGKSAKSSIISKKKRQTQSESSNYDSELE 784
Query: 537 KHANPAAKPRAGQTVNVNV--------------IVKDMGTDGKEELKADVVPVTLAPKKL 582
K +K A +T + K M G + LK T
Sbjct: 785 KEIKSMSKIGAARTTKKRIPNTKDFDSSEDEKHSKKGMDNQGHKNLK------TSQEGSS 838
Query: 583 DGASHTKPGEKLQVLKAKLQEAMKLRRFEER--QKRQALFKLDNEDGFEEEEEE----EE 636
D A + E + + + + +R +K+QA D D +E+ E
Sbjct: 839 DDAERKQERETFSSAEGTVDKDTTIMELRDRLPKKQQASASTDGVDKLSGKEQSFTSLEV 898
Query: 637 EMTDESEE------------------DGEEKVEKEEKEEELEEEEEKEEEEEEEGNQETA 678
E++E D EK K+++ +E E+++K+ ++ E ++ +
Sbjct: 899 RKVAETKEKSKHLKTKTCKKVQDGLSDIAEKFLKKDQSDETSEDDKKQSKKGTEEKKKPS 958
Query: 679 EFLLSSEEIETKDEKEMDKENNDGSSEIGKAVGFLSVPKSLSSDSTLLLFKDSSSKMGYF 738
+F ++E + E ++DG+ ++ + PK + + SK
Sbjct: 959 DFKKKVIKMEQQYES-----SSDGTEKLPEREEICHFPKGIKQIKNGTTDGEKKSKKIRD 1013
Query: 739 PTEEKSETDENSGKQPSKLDEDDSCSLLTKESSHNSSF-------ELIGSTIPSYQPCNR 791
T +K DE S + DSC + S N ++ +L+G + Q C+
Sbjct: 1014 KTSKKK--DELSDYAEKSTGKGDSCDSSEDKKSKNGAYGREKKRCKLLGKSSRKRQDCSS 1071
Query: 792 QTGRGTSFFPTAGGFRSPSPGLFRASLVSSASKSSGKLSEPSLPIEDSQDLYNASPEPK- 850
S G S L R L + SS + ++ S D +S + K
Sbjct: 1072 SDTEKYSM--KEDGCNSSDKRLKRIELRERRNLSSKRNTKEIQSGSSSSDAEESSEDNKK 1129
Query: 851 --------------------TLFLGAGDFQFCLEDDTQSQLLDADGFLNVRNHRNQYQAL 890
+L Q + + S + D D ++ + Q +
Sbjct: 1130 KKQRTSSKKKAVIVKEKKRNSLRTSTKRKQADITSSSSSDIEDDDQN-SIGEGSSDEQKI 1188
Query: 891 KPRLPLASMDENAMDANMDELLDLCTGKFTSQAEKHLPRKSDKKENMEELLNLCSGKFTS 950
KP + EN + + C K +P D ++ + N + K
Sbjct: 1189 KP------VTENLV---LSSHTGFCQSSGDEALSKSVPVTVDDDDDDNDPENRIAKKMLL 1239
Query: 951 QDASTPASSELNKQEKESSMGDPMEEALALCSGSFPTDKEEEDEEEEFGDFRLVSNDNEF 1010
++ SS+ ++ S D EE G T K+ E+ + V+++++
Sbjct: 1240 EEIKANLSSD-----EDGSSDDEPEE------GKKRTGKQNEENPGDEEAKNQVNSESDS 1288
Query: 1011 DSDEDE-----HSDSGNDLALEDHEDDDEEELLKRSEKLKRQMRLRKYLEDEAEVSGSDV 1065
DS+E + H + L + D E +E++ + K EV G +
Sbjct: 1289 DSEESKKPRYRHRLLRHKLTVSDGESGEEKKTKPKEHK---------------EVKGRNR 1333
Query: 1066 GSEDEYDGEEIDEYEEDVIDEVLPSDEELQSQIKKIHMKTMLDDDKRQLRLYQERYLADG 1125
D E+ D E V +EV S++E + + + K L++++R + ++R
Sbjct: 1334 RKVSSEDSEDSDFQESGVSEEVSESEDEQRPRTRSAK-KAELEENQRSYKQKKKRR---- 1388
Query: 1126 DLHSDGPGRMRKFRWKNIDDASQMDLFHRDSDDDQTEEQLDESEARWRKERIERE----- 1180
R K +D+S + + + ++++ EE+ +E E +E E +
Sbjct: 1389 -------------RIKVQEDSSSENKSNSEEEEEEKEEEEEEEEEEEEEEEDENDDSKSP 1435
Query: 1181 ----QWLRDMAQQGKITAEEEEEIGEDSQFMILAKKVTAKALQKNASRPMVIQESKSLLR 1236
+ +R + + K+ E + + E+ + K++ + ++ R ++ E S +
Sbjct: 1436 GKGRKKIRKILKDDKLRTETQNALKEEEE---RRKRIAEREREREKLREVIEIEDASPTK 1492
Query: 1237 NP 1238
P
Sbjct: 1493 CP 1494
Score = 50.4 bits (119), Expect = 1e-05
Identities = 52/239 (21%), Positives = 103/239 (43%), Gaps = 10/239 (4%)
Query: 43 EGDSDEEIFVSKKLKNRKVLQDSDSETEDTNASPEKTTYDSAEEENKENLYAGKNTKIKR 102
+G SD+E KK ++ ++ E + E DS EE+K+ Y ++ R
Sbjct: 1251 DGSSDDEPEEGKKRTGKQNEENPGDEEAKNQVNSES---DSDSEESKKPRY---RHRLLR 1304
Query: 103 IYKTVADSDESYMEKSLYQENLEAQVKPCLELSLQSGNSTDFTTDRKSSKKHIHDKEGTA 162
TV+D + +K+ +E+ E + + ++S + +DF S + + E
Sbjct: 1305 HKLTVSDGESGEEKKTKPKEHKEVKGRNRRKVSSEDSEDSDFQESGVSEEVSESEDEQ-- 1362
Query: 163 GKAKVKSKRRLEKEERKMEKIRQLKKKETKNQEDDVEQPFNDSGCLLVDKDLFETGLEDE 222
+ + +S ++ E EE + ++ K++ K QED + ++S +K+ E E+E
Sbjct: 1363 -RPRTRSAKKAELEENQRSYKQKKKRRRIKVQEDSSSENKSNSEEEEEEKEEEEEE-EEE 1420
Query: 223 NNSPLEDEESLESIRAAVKNKVKKHKKKEPSLESGVHSFEEGSELSKGTTRKERKAARL 281
EDE + K++K K + ++ +E E K +ER+ +L
Sbjct: 1421 EEEEEEDENDDSKSPGKGRKKIRKILKDDKLRTETQNALKEEEERRKRIAEREREREKL 1479
Score = 35.4 bits (80), Expect = 0.37
Identities = 39/174 (22%), Positives = 68/174 (39%), Gaps = 28/174 (16%)
Query: 41 LSEGDSDEEIFVSKKL------KNRKVLQDSDSETEDTNASPEKTTYDSAEEENKENLYA 94
+S+G+S EE K +NR+ + DSE D S +E+E + +
Sbjct: 1309 VSDGESGEEKKTKPKEHKEVKGRNRRKVSSEDSEDSDFQESGVSEEVSESEDEQRPRTRS 1368
Query: 95 GKNTKIK---RIYKTV-------ADSDESYMEKSLYQENLEAQVKPCLELSLQSGNSTDF 144
K +++ R YK D S KS +E E + + E + D
Sbjct: 1369 AKKAELEENQRSYKQKKKRRRIKVQEDSSSENKSNSEEEEEEKEEEEEEEEEEEEEEEDE 1428
Query: 145 TTDRKSSKK------------HIHDKEGTAGKAKVKSKRRLEKEERKMEKIRQL 186
D KS K + + A K + + ++R+ + ER+ EK+R++
Sbjct: 1429 NDDSKSPGKGRKKIRKILKDDKLRTETQNALKEEEERRKRIAEREREREKLREV 1482
Score = 35.0 bits (79), Expect = 0.48
Identities = 56/270 (20%), Positives = 100/270 (37%), Gaps = 23/270 (8%)
Query: 1023 DLALEDHEDDDEEELLKRSEKLKRQMRLRKYLEDEAEVSGSDVGSEDEYDGEEIDEYEED 1082
D + E EDD ++ EK K +K ++ E + S G+E + EEI + +
Sbjct: 934 DQSDETSEDDKKQSKKGTEEKKKPSDFKKKVIKMEQQYESSSDGTEKLPEREEICHFPKG 993
Query: 1083 VIDEVLPSDEELQSQIKKIHMKTMLDDDKRQLRLYQERYLADGD--------LHSDGPGR 1134
I ++ + + + KKI KT K +L Y E+ GD +G
Sbjct: 994 -IKQIKNGTTDGEKKSKKIRDKT--SKKKDELSDYAEKSTGKGDSCDSSEDKKSKNGAYG 1050
Query: 1135 MRKFRWKNIDDASQMDLFHRDSDDDQ----------TEEQLDESEARWRKERIEREQWLR 1184
K R K + +S+ SD ++ ++++L E R R+ +
Sbjct: 1051 REKKRCKLLGKSSRKRQDCSSSDTEKYSMKEDGCNSSDKRLKRIELRERRNLSSKRNTKE 1110
Query: 1185 DMAQQGKITAEEEEEIGEDSQFMILAKK--VTAKALQKNASRPMVIQESKSLLRNPFEAI 1242
+ AEE E + + +KK V K ++N+ R ++ + + I
Sbjct: 1111 IQSGSSSSDAEESSEDNKKKKQRTSSKKKAVIVKEKKRNSLRTSTKRKQADITSSSSSDI 1170
Query: 1243 RPGSAQQVKTGSLLNQPKAVLQKLAALSDH 1272
+ GS Q + + LS H
Sbjct: 1171 EDDDQNSIGEGSSDEQKIKPVTENLVLSSH 1200
>gi|20336209 transcriptional regulator ATRX isoform 1 [Homo sapiens]
Length = 2492
Score = 69.3 bits (168), Expect = 2e-11
Identities = 144/779 (18%), Positives = 304/779 (39%), Gaps = 104/779 (13%)
Query: 45 DSDEEIFVSKKLKNRKVLQDSDSETEDTNASPEKTTYDSAEEENKEN------------- 91
DSDE + + K++ SD++ + + + KT YD + K++
Sbjct: 730 DSDEMLAILKEVSRMSHSSSSDTDINEIHTN-HKTLYDLKTQAGKDDKGKRKRKSSTSGS 788
Query: 92 ---LYAGKNTKIKRIYKTVADSDESYMEKSLYQENLEAQVKPCLELSL------QSGNST 142
GK+ K I K ++ E S Y LE ++K ++ + N+
Sbjct: 789 DFDTKKGKSAKSSIISKK---KRQTQSESSNYDSELEKEIKSMSKIGAARTTKKRIPNTK 845
Query: 143 DFTT--DRKSSKKHIHDK---------EGTAGKAKVKSKRR--------LEKEERKMEKI 183
DF + D K SKK + ++ EG++ A+ K +R ++K+ ME
Sbjct: 846 DFDSSEDEKHSKKGMDNQGHKNLKTSQEGSSDDAERKQERETFSSAEGTVDKDTTIMELR 905
Query: 184 RQLKKKETKNQEDDVEQPFNDSGCLLVDKDLFETGLEDENNSPLEDEESLESIRAAVKNK 243
+L KK+ + D + ++ + E + L+ + + + ++ + +
Sbjct: 906 DRLPKKQQASASTDGVDKLSGKEQSFTSLEVRKVAETKEKSKHLKTK-TCKKVQDGLSDI 964
Query: 244 VKKHKKKEPSLESGVHSFEEGSELSKGTTRKERKAARLSKEALKQLHSETQRLIRESALN 303
+K KK+ S E+ E+ + SK T +++K + K+ +K E Q ES+ +
Sbjct: 965 AEKFLKKDQSDETS----EDDKKQSKKGTEEKKKPSDFKKKVIKM---EQQY---ESSSD 1014
Query: 304 LPYHMPENKTIHDFFKRKPRPTCHGNAMALLKSSKYQSSHHKEIIDTANTTEMNSDHHSK 363
+PE + I F K + +G KS K + K+ + ++ E ++ K
Sbjct: 1015 GTEKLPEREEICHFPKGI-KQIKNGTTDGEKKSKKIRDKTSKKKDELSDYAEKST---GK 1070
Query: 364 GSEQTTGAENEVETNALPVVSKETQIITGSDESCRKDLVKNEELEIQEKQKQSDIRPSPG 423
G + + + + A K +++ G R+D ++ + K+ +
Sbjct: 1071 GDSCDSSEDKKSKNGAYGREKKRCKLL-GKSSRKRQDCSSSDTEKYSMKEDGCNSSDKRL 1129
Query: 424 DSSVLQQESNFLGNNHSEECQVGGLVAFEPHALEGEGPQNPEETDEKVEEPEQQNKSSAV 483
L++ N +++E Q G + + ++ E+ +K + + K+ V
Sbjct: 1130 KRIELRERRNLSSKRNTKEIQSG--------SSSSDAEESSEDNKKKKQRTSSKKKAVIV 1181
Query: 484 GPPEKVRRFTLDRLKQLGVDVSIKPRLGADEDSFVILEPETNRELEALKQRFWKHANPAA 543
++ T + KQ + S + D+ + + ++++ + + ++
Sbjct: 1182 KEKKRNSLRTSTKRKQADITSSSSSDIEDDDQNSIGEGSSDEQKIKPVTENLVLSSHTGF 1241
Query: 544 KPRAGQTV---NVNVIVKDMGTDGKEE------LKADVVPVTLAPKKLDGASHTKPGEKL 594
+G +V V V D D E + + + L+ + DG+S +P E
Sbjct: 1242 CQSSGDEALSKSVPVTVDDDDDDNDPENRIAKKMLLEEIKANLSSDE-DGSSDDEPEEG- 1299
Query: 595 QVLKAKLQEAMKLRRFEERQKRQALFKLDNEDGFEEEEEEE---------EEMTDESEED 645
K + + + +E K Q +++E + EE ++ ++T E
Sbjct: 1300 ---KKRTGKQNEENPGDEEAKNQ----VNSESDSDSEESKKPRYRHRLLRHKLTVSDGES 1352
Query: 646 GEEKVEKEEKEEELEEEEEKEEEEEEEGNQETAEFLLSSEEIETKDE--------KEMDK 697
GEEK K ++ +E++ ++ E+ + + E +S E E++DE K+ +
Sbjct: 1353 GEEKKTKPKEHKEVKGRNRRKVSSEDSEDSDFQESGVSEEVSESEDEQRPRTRSAKKAEL 1412
Query: 698 ENNDGSSEIGKAVGFLSVPKSLSSDSTLLLFKDSSSKMGYFPTEEKSETDENSGKQPSK 756
E N S + K + V + SS++ ++ K EE+ E +E SK
Sbjct: 1413 EENQRSYKQKKKRRRIKVQEDSSSENKSNSEEEEEEKEEEEEEEEEEEEEEEDENDDSK 1471
Score = 68.2 bits (165), Expect = 5e-11
Identities = 149/743 (20%), Positives = 270/743 (36%), Gaps = 136/743 (18%)
Query: 57 KNRKVLQDSDSETEDTNASPEKTTYDSAEEENKENLY---AGKNTKIKRIYKTVADSDES 113
K K + S + E + YDS E+ +++ A + TK KRI T D D S
Sbjct: 793 KKGKSAKSSIISKKKRQTQSESSNYDSELEKEIKSMSKIGAARTTK-KRIPNT-KDFDSS 850
Query: 114 YMEKSLYQENLEAQVKPCLELSLQSGNSTDFTTDRKSSKKHIHDKEGTAGK--------- 164
EK ++ ++ Q L+ S Q G+S D +RK ++ EGT K
Sbjct: 851 EDEKHS-KKGMDNQGHKNLKTS-QEGSSDD--AERKQERETFSSAEGTVDKDTTIMELRD 906
Query: 165 ---------AKVKSKRRLEKEERKMEKIRQLKKKETKNQEDDVEQPFNDSGCLLVD---K 212
A +L +E+ + K ETK + ++ C V
Sbjct: 907 RLPKKQQASASTDGVDKLSGKEQSFTSLEVRKVAETKEKSKHLKT----KTCKKVQDGLS 962
Query: 213 DLFETGLE-DENNSPLEDEESLESIRAAVKNKVKKHKKKEPSLESGVHSFEEGSE----- 266
D+ E L+ D+++ ED++ K K KKK +E S +G+E
Sbjct: 963 DIAEKFLKKDQSDETSEDDKKQSKKGTEEKKKPSDFKKKVIKMEQQYESSSDGTEKLPER 1022
Query: 267 ------------LSKGTTRKERKAARLSKEALKQLHSETQRLIRESALNLPYHMPENKTI 314
+ GTT E+K+ ++ + K+ + + + E+K
Sbjct: 1023 EEICHFPKGIKQIKNGTTDGEKKSKKIRDKTSKKKDELSDYAEKSTGKGDSCDSSEDKKS 1082
Query: 315 HDFFKRKPRPTCHGNAMALLKSSKYQSSHHK-------------------EIIDTANTTE 355
+ + + C + K SS + E+ + N +
Sbjct: 1083 KNGAYGREKKRCKLLGKSSRKRQDCSSSDTEKYSMKEDGCNSSDKRLKRIELRERRNLSS 1142
Query: 356 MNSDHHSKGSEQTTGAENEVETNALPVVSKETQIITGSDESCRKDLVKNEELEIQEKQKQ 415
+ + ++ AE E N K+ Q + ++ K L K+KQ
Sbjct: 1143 KRNTKEIQSGSSSSDAEESSEDN-----KKKKQRTSSKKKAVIVKEKKRNSLRTSTKRKQ 1197
Query: 416 SDIRPSPGDSSVLQQESNFLGNNHSEECQVGGLVAFEPHALEGEGPQNPEETDEKVEE-- 473
+DI S S + + N +G S+E ++ + E L DE + +
Sbjct: 1198 ADITSS-SSSDIEDDDQNSIGEGSSDEQKIKPVT--ENLVLSSHTGFCQSSGDEALSKSV 1254
Query: 474 PEQQNKSSAVGPPEKVRRFTLDRLKQLGVDVSIKPRLGADEDSFVILEPETNRELEALKQ 533
P + PE +R+ + + IK L +DED EPE +
Sbjct: 1255 PVTVDDDDDDNDPE-------NRIAKKMLLEEIKANLSSDEDGSSDDEPEEGK------- 1300
Query: 534 RFWKHANPAAKPRAGQTVNVNVIVKDMGTDGKEELKADVVPVTLAPKKL--DGAS----H 587
K + G N + + +D +E K L K DG S
Sbjct: 1301 ---KRTGKQNEENPGDEEAKNQVNSESDSDSEESKKPRYRHRLLRHKLTVSDGESGEEKK 1357
Query: 588 TKPGEKLQVL------------------KAKLQEAMKLRRFEERQKRQALFKLDNEDGFE 629
TKP E +V ++ + E + E+R + ++ K + E+
Sbjct: 1358 TKPKEHKEVKGRNRRKVSSEDSEDSDFQESGVSEEVSESEDEQRPRTRSAKKAELEENQR 1417
Query: 630 EEEEEEE----EMTDESEEDGEEKVEKEEKEEELEEEEEKEEEEEEEGNQETAEF----- 680
+++++ ++ ++S + + E+EE+E+E EEEEE+EEEEEEE + ++
Sbjct: 1418 SYKQKKKRRRIKVQEDSSSENKSNSEEEEEEKEEEEEEEEEEEEEEEDENDDSKSPGKGR 1477
Query: 681 -----LLSSEEIETKDEKEMDKE 698
+L +++ T+ + + +E
Sbjct: 1478 KKIRKILKDDKLRTETQNALKEE 1500
Score = 65.9 bits (159), Expect = 3e-10
Identities = 225/1262 (17%), Positives = 448/1262 (35%), Gaps = 218/1262 (17%)
Query: 87 ENKENLYAGKNTKIKRIYKTVADSDESYMEKSLYQENLEAQVKPCLELSLQSGNSTDFTT 146
+N E A K ++K +AD ++++ +E+L ++ + ++ +
Sbjct: 379 DNSEISSATKLRQLKAFKSVLADIKKAHLA---LEEDLNSEFRAMDAVNKEKNTKEHKVI 435
Query: 147 DRKSS-------------KKHIHDKEGTAGKAKVKSK---RRLEKEERKMEKIRQLKKKE 190
D K KK I E + +V S+ + + EE++ K + K+
Sbjct: 436 DAKFETKARKGEKPCALEKKDISKSEAKLSRKQVDSEHMHQNVPTEEQRTNKSTGGEHKK 495
Query: 191 TKNQEDDVEQPFNDSGCLLVDKDLFETGLEDENNSPLEDEESLESIRAAVKNKVKKHKKK 250
+ +E+ +P N S L D D+ ++ P + E+LE+ +V+
Sbjct: 496 SDRKEEPQYEPANTSEDL--DMDIVSV----PSSVPEDIFENLETAM-----EVQSSVDH 544
Query: 251 EPSLESGVHSFEEGSELSKGTTRKERKAARLSKEALKQLHSETQRLIRESALNLPY---- 306
+ SG E S + + K+ + SK K +L S N P
Sbjct: 545 QGDGSSGTEQEVESSSVKLNISSKDNRGGIKSKTTAKVTKELYVKLTPVSLSNSPIKGAD 604
Query: 307 --HMPENKTIHDFFKRKPRPTCHGNAMALLKSSKYQSSHHKEIIDTANTTEMN-SDHHSK 363
+P++K D +K +C N ++S ++ +++ + + SD
Sbjct: 605 CQEVPQDK---DGYK-----SCGLNPKLEKCGLGQENSDNEHLVENEVSLLLEESDLRRS 656
Query: 364 GSEQTTGAENEVETNALPVVSKETQIITGSDESCRKDLVKNEELEIQEKQKQSDIRPSPG 423
+TT ETN PV S SDE C + + + ++L + ++K + +
Sbjct: 657 PRVKTTPLRRPTETN--PVTSN-------SDEECNETVKEKQKLSVPVRKKD---KRNSS 704
Query: 424 DSSVLQQESNFLGNNHSEECQVGGLVAFEPHAL--EGEGPQNPEETDEKVEEPEQQNKS- 480
DS++ + N L + E + E A+ E + +D + E +K+
Sbjct: 705 DSAIDNPKPNKLPKSKQSETVDQNSDSDEMLAILKEVSRMSHSSSSDTDINEIHTNHKTL 764
Query: 481 ----SAVGPPEKVRRFTLDRLKQLGVDVSIKPRLGADEDSFVILEPETNRELEALKQRFW 536
+ G +K +R + G D K A + +T E
Sbjct: 765 YDLKTQAGKDDKGKRKR--KSSTSGSDFDTKKGKSAKSSIISKKKRQTQSESSNYDSELE 822
Query: 537 KHANPAAKPRAGQTVNVNV--------------IVKDMGTDGKEELKADVVPVTLAPKKL 582
K +K A +T + K M G + LK T
Sbjct: 823 KEIKSMSKIGAARTTKKRIPNTKDFDSSEDEKHSKKGMDNQGHKNLK------TSQEGSS 876
Query: 583 DGASHTKPGEKLQVLKAKLQEAMKLRRFEER--QKRQALFKLDNEDGFEEEEEE----EE 636
D A + E + + + + +R +K+QA D D +E+ E
Sbjct: 877 DDAERKQERETFSSAEGTVDKDTTIMELRDRLPKKQQASASTDGVDKLSGKEQSFTSLEV 936
Query: 637 EMTDESEE------------------DGEEKVEKEEKEEELEEEEEKEEEEEEEGNQETA 678
E++E D EK K+++ +E E+++K+ ++ E ++ +
Sbjct: 937 RKVAETKEKSKHLKTKTCKKVQDGLSDIAEKFLKKDQSDETSEDDKKQSKKGTEEKKKPS 996
Query: 679 EFLLSSEEIETKDEKEMDKENNDGSSEIGKAVGFLSVPKSLSSDSTLLLFKDSSSKMGYF 738
+F ++E + E ++DG+ ++ + PK + + SK
Sbjct: 997 DFKKKVIKMEQQYES-----SSDGTEKLPEREEICHFPKGIKQIKNGTTDGEKKSKKIRD 1051
Query: 739 PTEEKSETDENSGKQPSKLDEDDSCSLLTKESSHNSSF-------ELIGSTIPSYQPCNR 791
T +K DE S + DSC + S N ++ +L+G + Q C+
Sbjct: 1052 KTSKKK--DELSDYAEKSTGKGDSCDSSEDKKSKNGAYGREKKRCKLLGKSSRKRQDCSS 1109
Query: 792 QTGRGTSFFPTAGGFRSPSPGLFRASLVSSASKSSGKLSEPSLPIEDSQDLYNASPEPK- 850
S G S L R L + SS + ++ S D +S + K
Sbjct: 1110 SDTEKYSM--KEDGCNSSDKRLKRIELRERRNLSSKRNTKEIQSGSSSSDAEESSEDNKK 1167
Query: 851 --------------------TLFLGAGDFQFCLEDDTQSQLLDADGFLNVRNHRNQYQAL 890
+L Q + + S + D D ++ + Q +
Sbjct: 1168 KKQRTSSKKKAVIVKEKKRNSLRTSTKRKQADITSSSSSDIEDDDQN-SIGEGSSDEQKI 1226
Query: 891 KPRLPLASMDENAMDANMDELLDLCTGKFTSQAEKHLPRKSDKKENMEELLNLCSGKFTS 950
KP + EN + + C K +P D ++ + N + K
Sbjct: 1227 KP------VTENLV---LSSHTGFCQSSGDEALSKSVPVTVDDDDDDNDPENRIAKKMLL 1277
Query: 951 QDASTPASSELNKQEKESSMGDPMEEALALCSGSFPTDKEEEDEEEEFGDFRLVSNDNEF 1010
++ SS+ ++ S D EE G T K+ E+ + V+++++
Sbjct: 1278 EEIKANLSSD-----EDGSSDDEPEE------GKKRTGKQNEENPGDEEAKNQVNSESDS 1326
Query: 1011 DSDEDE-----HSDSGNDLALEDHEDDDEEELLKRSEKLKRQMRLRKYLEDEAEVSGSDV 1065
DS+E + H + L + D E +E++ + K EV G +
Sbjct: 1327 DSEESKKPRYRHRLLRHKLTVSDGESGEEKKTKPKEHK---------------EVKGRNR 1371
Query: 1066 GSEDEYDGEEIDEYEEDVIDEVLPSDEELQSQIKKIHMKTMLDDDKRQLRLYQERYLADG 1125
D E+ D E V +EV S++E + + + K L++++R + ++R
Sbjct: 1372 RKVSSEDSEDSDFQESGVSEEVSESEDEQRPRTRSAK-KAELEENQRSYKQKKKRR---- 1426
Query: 1126 DLHSDGPGRMRKFRWKNIDDASQMDLFHRDSDDDQTEEQLDESEARWRKERIERE----- 1180
R K +D+S + + + ++++ EE+ +E E +E E +
Sbjct: 1427 -------------RIKVQEDSSSENKSNSEEEEEEKEEEEEEEEEEEEEEEDENDDSKSP 1473
Query: 1181 ----QWLRDMAQQGKITAEEEEEIGEDSQFMILAKKVTAKALQKNASRPMVIQESKSLLR 1236
+ +R + + K+ E + + E+ + K++ + ++ R ++ E S +
Sbjct: 1474 GKGRKKIRKILKDDKLRTETQNALKEEEE---RRKRIAEREREREKLREVIEIEDASPTK 1530
Query: 1237 NP 1238
P
Sbjct: 1531 CP 1532
Score = 50.4 bits (119), Expect = 1e-05
Identities = 52/239 (21%), Positives = 103/239 (43%), Gaps = 10/239 (4%)
Query: 43 EGDSDEEIFVSKKLKNRKVLQDSDSETEDTNASPEKTTYDSAEEENKENLYAGKNTKIKR 102
+G SD+E KK ++ ++ E + E DS EE+K+ Y ++ R
Sbjct: 1289 DGSSDDEPEEGKKRTGKQNEENPGDEEAKNQVNSES---DSDSEESKKPRY---RHRLLR 1342
Query: 103 IYKTVADSDESYMEKSLYQENLEAQVKPCLELSLQSGNSTDFTTDRKSSKKHIHDKEGTA 162
TV+D + +K+ +E+ E + + ++S + +DF S + + E
Sbjct: 1343 HKLTVSDGESGEEKKTKPKEHKEVKGRNRRKVSSEDSEDSDFQESGVSEEVSESEDEQ-- 1400
Query: 163 GKAKVKSKRRLEKEERKMEKIRQLKKKETKNQEDDVEQPFNDSGCLLVDKDLFETGLEDE 222
+ + +S ++ E EE + ++ K++ K QED + ++S +K+ E E+E
Sbjct: 1401 -RPRTRSAKKAELEENQRSYKQKKKRRRIKVQEDSSSENKSNSEEEEEEKEEEEEE-EEE 1458
Query: 223 NNSPLEDEESLESIRAAVKNKVKKHKKKEPSLESGVHSFEEGSELSKGTTRKERKAARL 281
EDE + K++K K + ++ +E E K +ER+ +L
Sbjct: 1459 EEEEEEDENDDSKSPGKGRKKIRKILKDDKLRTETQNALKEEEERRKRIAEREREREKL 1517
Score = 35.4 bits (80), Expect = 0.37
Identities = 39/174 (22%), Positives = 68/174 (39%), Gaps = 28/174 (16%)
Query: 41 LSEGDSDEEIFVSKKL------KNRKVLQDSDSETEDTNASPEKTTYDSAEEENKENLYA 94
+S+G+S EE K +NR+ + DSE D S +E+E + +
Sbjct: 1347 VSDGESGEEKKTKPKEHKEVKGRNRRKVSSEDSEDSDFQESGVSEEVSESEDEQRPRTRS 1406
Query: 95 GKNTKIK---RIYKTV-------ADSDESYMEKSLYQENLEAQVKPCLELSLQSGNSTDF 144
K +++ R YK D S KS +E E + + E + D
Sbjct: 1407 AKKAELEENQRSYKQKKKRRRIKVQEDSSSENKSNSEEEEEEKEEEEEEEEEEEEEEEDE 1466
Query: 145 TTDRKSSKK------------HIHDKEGTAGKAKVKSKRRLEKEERKMEKIRQL 186
D KS K + + A K + + ++R+ + ER+ EK+R++
Sbjct: 1467 NDDSKSPGKGRKKIRKILKDDKLRTETQNALKEEEERRKRIAEREREREKLREV 1520
Score = 35.0 bits (79), Expect = 0.48
Identities = 56/270 (20%), Positives = 100/270 (37%), Gaps = 23/270 (8%)
Query: 1023 DLALEDHEDDDEEELLKRSEKLKRQMRLRKYLEDEAEVSGSDVGSEDEYDGEEIDEYEED 1082
D + E EDD ++ EK K +K ++ E + S G+E + EEI + +
Sbjct: 972 DQSDETSEDDKKQSKKGTEEKKKPSDFKKKVIKMEQQYESSSDGTEKLPEREEICHFPKG 1031
Query: 1083 VIDEVLPSDEELQSQIKKIHMKTMLDDDKRQLRLYQERYLADGD--------LHSDGPGR 1134
I ++ + + + KKI KT K +L Y E+ GD +G
Sbjct: 1032 -IKQIKNGTTDGEKKSKKIRDKT--SKKKDELSDYAEKSTGKGDSCDSSEDKKSKNGAYG 1088
Query: 1135 MRKFRWKNIDDASQMDLFHRDSDDDQ----------TEEQLDESEARWRKERIEREQWLR 1184
K R K + +S+ SD ++ ++++L E R R+ +
Sbjct: 1089 REKKRCKLLGKSSRKRQDCSSSDTEKYSMKEDGCNSSDKRLKRIELRERRNLSSKRNTKE 1148
Query: 1185 DMAQQGKITAEEEEEIGEDSQFMILAKK--VTAKALQKNASRPMVIQESKSLLRNPFEAI 1242
+ AEE E + + +KK V K ++N+ R ++ + + I
Sbjct: 1149 IQSGSSSSDAEESSEDNKKKKQRTSSKKKAVIVKEKKRNSLRTSTKRKQADITSSSSSDI 1208
Query: 1243 RPGSAQQVKTGSLLNQPKAVLQKLAALSDH 1272
+ GS Q + + LS H
Sbjct: 1209 EDDDQNSIGEGSSDEQKIKPVTENLVLSSH 1238
>gi|239745095 PREDICTED: hypothetical protein LOC645202 [Homo
sapiens]
Length = 570
Score = 67.0 bits (162), Expect = 1e-10
Identities = 38/117 (32%), Positives = 68/117 (58%), Gaps = 3/117 (2%)
Query: 592 EKLQVLKAKLQEAMKLRRFEERQKRQALFKLDNEDGFEEEE---EEEEEMTDESEEDGEE 648
EK++ + K QE K+R E+RQ+++A E E+EE E+EE M ++ E+ GE+
Sbjct: 357 EKIREQEEKRQEEEKIREQEKRQEQEAKMWRQEEKIREQEEKIREQEEMMQEQEEKMGEQ 416
Query: 649 KVEKEEKEEELEEEEEKEEEEEEEGNQETAEFLLSSEEIETKDEKEMDKENNDGSSE 705
+ + E+EEE++E+EEK +EE+ ++ + E+I ++E ++E G E
Sbjct: 417 EEKMWEQEEEMQEQEEKMRRQEEKIREQEKKIREQEEKIREQEEMMQEQEEKMGEQE 473
Score = 57.0 bits (136), Expect = 1e-07
Identities = 39/121 (32%), Positives = 67/121 (55%), Gaps = 7/121 (5%)
Query: 592 EKLQVLKAKLQEAM-KLRRFEERQKRQALFKLDNEDGFEEEEE---EEEEMTDESEED-- 645
EK+Q + K+QE K+R EE+ +RQ + E+ +EE E+EE E EE
Sbjct: 295 EKIQEREEKIQEQEEKIREQEEKMRRQEEMMWEKEEKMRRQEEMMWEKEEKIRELEEKMH 354
Query: 646 GEEKV-EKEEKEEELEEEEEKEEEEEEEGNQETAEFLLSSEEIETKDEKEMDKENNDGSS 704
+EK+ E+EEK +E E+ E+E+ +E+E E + +E + ++++EM +E +
Sbjct: 355 EQEKIREQEEKRQEEEKIREQEKRQEQEAKMWRQEEKIREQEEKIREQEEMMQEQEEKMG 414
Query: 705 E 705
E
Sbjct: 415 E 415
Score = 52.0 bits (123), Expect = 4e-06
Identities = 40/129 (31%), Positives = 67/129 (51%), Gaps = 10/129 (7%)
Query: 577 LAPKKLDGASHTKPGEKLQVLKAKLQEAMKLRRFEERQKRQALFKLDNEDGFEEEEEEEE 636
L P++ A G++LQ + AKLQ ++ R +Q K+ + EE+ +E E
Sbjct: 245 LLPQQQLQAEADHLGKELQSVSAKLQAQVEENELWNRLNQQQEEKMWRQ---EEKIQERE 301
Query: 637 EMTDESEEDGEEKVEKEEKEEEL----EEEEEKEEE---EEEEGNQETAEFLLSSEEIET 689
E E EE E+ EK ++EE+ EE+ ++EE E+EE +E E + E+I
Sbjct: 302 EKIQEQEEKIREQEEKMRRQEEMMWEKEEKMRRQEEMMWEKEEKIRELEEKMHEQEKIRE 361
Query: 690 KDEKEMDKE 698
++EK ++E
Sbjct: 362 QEEKRQEEE 370
Score = 52.0 bits (123), Expect = 4e-06
Identities = 35/119 (29%), Positives = 67/119 (56%), Gaps = 12/119 (10%)
Query: 592 EKLQVLKAKL-QEAMKLRRFEERQKRQALFKLDNEDGFEEEEE----EEEEMTDESEE-- 644
EK Q +AK+ ++ K+R EE+ + Q + E+ E+EE +EEEM ++ E+
Sbjct: 376 EKRQEQEAKMWRQEEKIREQEEKIREQEEMMQEQEEKMGEQEEKMWEQEEEMQEQEEKMR 435
Query: 645 DGEEKVEKEEK-----EEELEEEEEKEEEEEEEGNQETAEFLLSSEEIETKDEKEMDKE 698
EEK+ ++EK EE++ E+EE +E+EE+ ++ + +++ ++EK +E
Sbjct: 436 RQEEKIREQEKKIREQEEKIREQEEMMQEQEEKMGEQEGKMCEQEAKMQEQEEKMRRQE 494
Score = 49.7 bits (117), Expect = 2e-05
Identities = 28/107 (26%), Positives = 62/107 (57%), Gaps = 2/107 (1%)
Query: 592 EKLQVLKAKLQEAMKLRRFEERQKRQALFKLDNEDGFEEEEEEEEEMTDESEEDGEEKVE 651
EK+ + ++QE + R +E + R+ K+ ++ E+ E+EE M ++ E+ GE++ +
Sbjct: 418 EKMWEQEEEMQEQEEKMRRQEEKIREQEKKIREQE--EKIREQEEMMQEQEEKMGEQEGK 475
Query: 652 KEEKEEELEEEEEKEEEEEEEGNQETAEFLLSSEEIETKDEKEMDKE 698
E+E +++E+EEK +EE+ ++ + E+I ++E ++E
Sbjct: 476 MCEQEAKMQEQEEKMRRQEEKIREQEKKIREQEEKIREQEEMMQEQE 522
Score = 49.7 bits (117), Expect = 2e-05
Identities = 30/120 (25%), Positives = 68/120 (56%), Gaps = 5/120 (4%)
Query: 592 EKLQVLKAKLQEAMKLRRFEERQKRQALFKLDNEDG--FEEE---EEEEEEMTDESEEDG 646
EK++ + K++E + R +E ++ K+ ++G E+E +E+EE+M + E+
Sbjct: 439 EKIREQEKKIREQEEKIREQEEMMQEQEEKMGEQEGKMCEQEAKMQEQEEKMRRQEEKIR 498
Query: 647 EEKVEKEEKEEELEEEEEKEEEEEEEGNQETAEFLLSSEEIETKDEKEMDKENNDGSSEI 706
E++ + E+EE++ E+EE +E+EE+ ++ + E+++ ++EK +E E+
Sbjct: 499 EQEKKIREQEEKIREQEEMMQEQEEKMWEQEEKMCEQEEKMQEQEEKMRRQEEKMREQEV 558
Score = 49.3 bits (116), Expect = 2e-05
Identities = 32/102 (31%), Positives = 57/102 (55%), Gaps = 5/102 (4%)
Query: 592 EKLQVLKAKL-QEAMKLRRFEERQKRQALFKLDNEDGFEEEEE---EEEEMTDESEEDGE 647
EK+ + K+ ++ K++ EE+ +RQ + E E+EE E+EEM E EE
Sbjct: 467 EKMGEQEGKMCEQEAKMQEQEEKMRRQEEKIREQEKKIREQEEKIREQEEMMQEQEEKMW 526
Query: 648 EKVEKE-EKEEELEEEEEKEEEEEEEGNQETAEFLLSSEEIE 688
E+ EK E+EE+++E+EEK +EE+ ++ E+++
Sbjct: 527 EQEEKMCEQEEKMQEQEEKMRRQEEKMREQEVRLRQQEEKMQ 568
Score = 43.1 bits (100), Expect = 0.002
Identities = 68/372 (18%), Positives = 165/372 (44%), Gaps = 35/372 (9%)
Query: 890 LKPRLPLASMDENAMDANMDELLDLCTGKFTSQAEKHLPRKSDKKE--NMEELLNLCSGK 947
L+ +L L +++ + N+ EL + +A+ LP++ + E ++ + L S K
Sbjct: 214 LQEKLQLVESEKSEIQLNVKELK-----RKLERAKLLLPQQQLQAEADHLGKELQSVSAK 268
Query: 948 FTSQDASTPASSELNKQEKESSMGDPMEEALALCSGSFPTDKEEEDEEEEF---GDFRLV 1004
+Q + LN+Q++E EE + +E+ E+EE + +
Sbjct: 269 LQAQVEENELWNRLNQQQEEKMWRQ--EEKIQEREEKIQEQEEKIREQEEKMRRQEEMMW 326
Query: 1005 SNDNEFDSDED---EHSDSGNDLALEDHEDD---------DEEELLKRSEKLKRQMRLRK 1052
+ + E+ E + +L + HE + EEE ++ EK +++ +
Sbjct: 327 EKEEKMRRQEEMMWEKEEKIRELEEKMHEQEKIREQEEKRQEEEKIREQEK-RQEQEAKM 385
Query: 1053 YLEDEAEVSGSDVGSEDEYDGEEIDEYEEDVIDEVLPSDEELQSQIKKI-HMKTMLDDDK 1111
+ ++E + E E +E +E + +++ +EE+Q Q +K+ + + + +
Sbjct: 386 WRQEEKIREQEEKIREQEEMMQEQEEKMGEQEEKMWEQEEEMQEQEEKMRRQEEKIREQE 445
Query: 1112 RQLRLYQERYLADGDLHSDGPGRMRKFRWKNIDDASQMDLFHRDSDDDQTEEQLDESEAR 1171
+++R +E+ ++ + +M + K + ++M ++ + EE++ E E +
Sbjct: 446 KKIREQEEKIREQEEMMQEQEEKMGEQEGKMCEQEAKMQ--EQEEKMRRQEEKIREQEKK 503
Query: 1172 WRKERIEREQWLRDMAQQGKITAEEEEEIGEDSQFMILAKKVTAKALQKNASRPMVIQES 1231
R E+E+ +R +Q ++ E+EE++ E + M ++ + +K + ++E
Sbjct: 504 IR----EQEEKIR---EQEEMMQEQEEKMWEQEEKMCEQEEKMQEQEEKMRRQEEKMREQ 556
Query: 1232 KSLLRNPFEAIR 1243
+ LR E ++
Sbjct: 557 EVRLRQQEEKMQ 568
Score = 42.0 bits (97), Expect = 0.004
Identities = 30/89 (33%), Positives = 49/89 (55%), Gaps = 11/89 (12%)
Query: 592 EKLQVLKAKLQEA-MKLRRFEERQKRQALFKLDNEDGFEEEEE---EEEEMTDESEEDGE 647
EK++ + K++E K+R EE+ + Q E+ +E+EE E+EE E EE +
Sbjct: 488 EKMRRQEEKIREQEKKIREQEEKIREQ-------EEMMQEQEEKMWEQEEKMCEQEEKMQ 540
Query: 648 EKVEKEEKEEELEEEEEKEEEEEEEGNQE 676
E+ EK ++EE E+E ++EE QE
Sbjct: 541 EQEEKMRRQEEKMREQEVRLRQQEEKMQE 569
Score = 37.0 bits (84), Expect = 0.13
Identities = 34/224 (15%), Positives = 97/224 (43%), Gaps = 12/224 (5%)
Query: 77 EKTTYDSAEEENKENLYAGKNTKIKRIYKTVADSDESYMEKSLYQENLEAQVKPCLELSL 136
E ++ ++ +E ++ + KI+ + + + +E E+ +E + Q + E
Sbjct: 275 ENELWNRLNQQQEEKMWR-QEEKIQEREEKIQEQEEKIREQ---EEKMRRQEEMMWEKEE 330
Query: 137 QSGNSTDFTTDRKSSKKHIHDKEGTAGKAKVKSKRRLEKEERKMEKIRQLKKKETKNQED 196
+ + +++ + + +K K + + ++R E+E+ + ++ RQ ++ + QE+
Sbjct: 331 KMRRQEEMMWEKEEKIRELEEKMHEQEKIREQEEKRQEEEKIREQEKRQEQEAKMWRQEE 390
Query: 197 DV---EQPFNDSGCLLVDKDLFETGLEDENNSPLEDEESLESIRAAVKNKVKKHKKKEPS 253
+ E+ + ++ ++ E + ++ E EE ++ ++ + +K +++E
Sbjct: 391 KIREQEEKIREQEEMMQEQ---EEKMGEQEEKMWEQEEEMQEQEEKMRRQEEKIREQEKK 447
Query: 254 LESGVHSFEEGSELSKGTTRK--ERKAARLSKEALKQLHSETQR 295
+ E E+ + K E++ +EA Q E R
Sbjct: 448 IREQEEKIREQEEMMQEQEEKMGEQEGKMCEQEAKMQEQEEKMR 491
Score = 32.3 bits (72), Expect = 3.1
Identities = 39/216 (18%), Positives = 86/216 (39%), Gaps = 35/216 (16%)
Query: 48 EEIFVSKKLKNRKVLQDSDSETEDTNASPEKTTYDSAEEENKENLYAGKNTKIKRIYKTV 107
EE ++ K R+ + + E EK E + +E + KI+ K +
Sbjct: 389 EEKIREQEEKIREQEEMMQEQEEKMGEQEEKMWEQEEEMQEQEEKMRRQEEKIREQEKKI 448
Query: 108 ADSDESYMEKSLYQENLEAQVKPCLELSLQSGNSTDFTTDRKSSKKHIHDKEGTAGKAKV 167
+ +E E+ +E ++ Q ++ + ++EG + +
Sbjct: 449 REQEEKIREQ---EEMMQEQ------------------------EEKMGEQEGKMCEQEA 481
Query: 168 KSKRRLEKEERKMEKIRQLKKKETKNQEDDVEQPFNDSGCLLVDKDLFETGLEDENNSPL 227
K + + EK R+ EKIR+ +KK + +E EQ ++ ++ E + ++
Sbjct: 482 KMQEQEEKMRRQEEKIREQEKKIREQEEKIREQEE-----MMQEQ---EEKMWEQEEKMC 533
Query: 228 EDEESLESIRAAVKNKVKKHKKKEPSLESGVHSFEE 263
E EE ++ ++ + +K +++E L +E
Sbjct: 534 EQEEKMQEQEEKMRRQEEKMREQEVRLRQQEEKMQE 569
Score = 32.0 bits (71), Expect = 4.1
Identities = 28/123 (22%), Positives = 62/123 (50%), Gaps = 11/123 (8%)
Query: 587 HTKPGEKLQVLKAKLQEAMKLRRFEERQKRQALFKLDNEDGFEEEEEEEEEMTDESEEDG 646
+T E+L+ AKLQE ++L E+ + + + +L + + ++++ E++ G
Sbjct: 200 NTITDEELKEKNAKLQEKLQLVESEKSEIQLNVKELKRKLERAKLLLPQQQLQAEADHLG 259
Query: 647 EE------KVEKEEKEEEL-----EEEEEKEEEEEEEGNQETAEFLLSSEEIETKDEKEM 695
+E K++ + +E EL +++EEK +EE+ + + E+I ++EK
Sbjct: 260 KELQSVSAKLQAQVEENELWNRLNQQQEEKMWRQEEKIQEREEKIQEQEEKIREQEEKMR 319
Query: 696 DKE 698
+E
Sbjct: 320 RQE 322
>gi|148746195 trichohyalin [Homo sapiens]
Length = 1943
Score = 67.0 bits (162), Expect = 1e-10
Identities = 202/1165 (17%), Positives = 425/1165 (36%), Gaps = 143/1165 (12%)
Query: 148 RKSSKKHIHDKEGTAGKAKVKSKRRLEKEERKM--EKIRQLKKKETKNQEDDVEQPFNDS 205
R+ K+ ++E G+ + + + RLE+ +R+ E++ + +++ + +E E+ S
Sbjct: 136 RRRQKRQEQERELAEGEEQSEKQERLEQRDRQRRDEELWRQRQEWQEREERRAEEEQLQS 195
Query: 206 GCLLVDKDLFETGLEDENNSPLEDEESLESIRAAVKNKVKKHKKKEPSLESGVHSFEEGS 265
+ DEE L + + +K++ E F+E
Sbjct: 196 -------------CKGHETEEFPDEEQLRRRELLELRRKGREEKQQQRRERQDRVFQEEE 242
Query: 266 ELSKGTTRKERKAARLSKEALKQLHSETQRLIRESALNLPYHMPENKTIHDFFKRKPRPT 325
E RK R +E L++ + QR ++E E + + +++ R
Sbjct: 243 EKE---WRKRETVLRKEEEKLQEEEPQRQRELQE----------EEEQLRKLERQELRRE 289
Query: 326 CHGNAMALLKSSKYQSSHHKEIIDTANTTEMNSDHHSKGSEQTTGAENEVETNALPVVSK 385
+ + Q K+ + E + + +Q E ++ +
Sbjct: 290 RQEEEQQQQRLRREQQLRRKQEEERREQQEERREQQERREQQEERREQQLRREQEE--RR 347
Query: 386 ETQIITGSDESCRKDLVKNEELEIQEKQKQSDIRPSPGDSSVLQQESNFLGNNHSEECQV 445
E Q+ +E R+ ++ E+ E + +Q+ + + + +++ E Q+
Sbjct: 348 EQQLRREQEEERREQQLRREQEEERREQQLRREQQLRREQQLRREQQLRREQQLRREQQL 407
Query: 446 GGLVAFE-PHALEGEGPQNPEETDEKVEEP-EQQNKSSAVGPPEKVRRFTLDRLKQLG-- 501
L E E+ +E+ E+ EQ+ + + ++ RR L R ++
Sbjct: 408 RREQQLRREQQLRREQQLRREQEEERHEQKHEQERREQRLKREQEERRDWLKREEETERH 467
Query: 502 VDVSIKPRLGADEDS-----FVILEPETNREL-EALKQRFWKHANPAAKPRAGQTVNVNV 555
K +L D++ ++ LE E RE E +Q+ + + R +
Sbjct: 468 EQERRKQQLKRDQEEERRERWLKLEEEERREQQERREQQLRREQEERREQRLKRQEEEER 527
Query: 556 IVKDMGTDGKEELKADVVPVTLAPKKLDGASHTKPGEKLQVLKAKLQEAMKLRRFEERQK 615
+ + + ++ ++L+ + K + + + Q LK + +E E ++
Sbjct: 528 LQQRLRSE--QQLRREQEERREQLLKREEEKRLEQERREQRLKREQEERRDQLLKREEER 585
Query: 616 RQALFKLDNEDGFEEEEEEEEEMTDESEEDGEEKVEKEEKEEELEEEEEKEEEEEE---- 671
RQ K + E+ E+ + EE E EE E+++++EE EEE ++ K EE+EE
Sbjct: 586 RQQRLKREQEERLEQRLKREEVERLEQEERREQRLKREEPEEERRQQLLKSEEQEERRQQ 645
Query: 672 ----------------EGNQETAEFLLSSEEIETKDEKEMDKENNDGSSEIGKAVGFLSV 715
E +E E L E E + E+E+ +E + + E K+ +
Sbjct: 646 QLRREQQERREQRLKREEEEERLEQRLKREHEEERREQELAEEEQEQARERIKS----RI 701
Query: 716 PK---SLSSDSTLLLFKDSSSKMGYFPTEEKSETDENSGKQPSKLDEDDSCSLLTKESSH 772
PK L S++ K S + E +E ++ S+L + +E +H
Sbjct: 702 PKWQWQLESEADARQSKVYSRPRKQEGQRRRQEQEEKRRRRESELQWQE------EERAH 755
Query: 773 NSSFELIGSTIPSYQ-PCNRQTGRGTSFFPTAGGFRSPSPGLFRASLVSSASKSSGKLSE 831
E ++Q ++ RG R RA + + +
Sbjct: 756 RQQQEEEQRRDFTWQWQAEEKSERGRQRLSARPPLREQRERQLRA-------EERQQREQ 808
Query: 832 PSLPIEDSQDLYNASPEPKTLFLGAGDFQFCLEDDTQSQLLDADGFLNVRNHRNQYQALK 891
LP E+ ++ E + + Q L+ + L R Q Q +
Sbjct: 809 RFLPEEEEKEQRRRQRR---------------EREKELQFLEEEEQLQRRERAQQLQEEE 853
Query: 892 PRLPLASMDENAMDANMDELLDLCTGKFTSQAEKHLPRK----------SDKKENMEELL 941
L + + D+ K+ Q E+ R+ ++ ++LL
Sbjct: 854 DGLQEDQERRRSQEQRRDQ-------KWRWQLEEERKRRRHTLYAKPALQEQLRKEQQLL 906
Query: 942 NLCSGKFTSQDASTPASSELNKQEKESSMGDPMEEALALCSGSFPTDKEEEDEEEEFGDF 1001
+ ++ E +Q +E EE L + +E E + D
Sbjct: 907 QEEEEELQREEREKRRRQEQERQYREEEQLQQEEEQLL--REEREKRRRQERERQYRKDK 964
Query: 1002 RLVSNDNEFDSDEDE---HSDSGNDLALEDHEDDDEEELLKRS-EKLKRQMRLRKYLEDE 1057
+L + + +E E + E+ +EE+LL+ EK +RQ R+Y + +
Sbjct: 965 KLQQKEEQLLGEEPEKRRRQEREKKYREEEELQQEEEQLLREEREKRRRQEWERQYRKKD 1024
Query: 1058 AEVSGSDVGSEDEYDGEEIDEYEEDV--IDEVLPSDEELQSQIKKIHMKTMLDDDKRQLR 1115
+ +E + + E E +E+ +E+L + ++ + L+ RQ R
Sbjct: 1025 ELQQEEEQLLREEREKRRLQERERQYREEEELQQEEEQLLGEERETRRRQELE---RQYR 1081
Query: 1116 LYQERYLADGDLHSDGPGRMRKFRWKNIDDASQMDLFHRDSDDDQTEEQLDESEARWRKE 1175
+E + L + P + R+ + R +++ +Q +E R +E
Sbjct: 1082 KEEELQQEEEQLLREEPEKRRRQERE------------RQCREEEELQQEEEQLLREERE 1129
Query: 1176 RIEREQWLRDMAQQGKITAEEEEEIGEDSQFMILAKKVTAKALQKNASRPMVIQESKSLL 1235
+ R++ R ++ ++ EEE+ + E+ + K+ + ++ + QE + LL
Sbjct: 1130 KRRRQELERQYREEEEVQQEEEQLLREEPE-----KRRRQELERQYREEEELQQEEEQLL 1184
Query: 1236 RNPFEAIRPGSAQQVKTGSLLNQPK 1260
R E R +Q + L + K
Sbjct: 1185 REEQEKRRQERERQYREEEELQRQK 1209
Score = 64.3 bits (155), Expect = 7e-10
Identities = 121/653 (18%), Positives = 254/653 (38%), Gaps = 68/653 (10%)
Query: 85 EEENKENLYAGKNTKIKRIYKTVADSDESYMEKSLYQENLEAQVKPCLE-----LSLQSG 139
E++ + + +++R + + +E E+ QE E ++K E L +
Sbjct: 404 EQQLRREQQLRREQQLRREQQLRREQEEERHEQKHEQERREQRLKREQEERRDWLKREEE 463
Query: 140 NSTDFTTDRKSSKKHIHDKEGTAGKAKVKSKRRLEKEERKMEKIR--QLKKKETKNQEDD 197
RK K ++E K++ + R E++ER+ +++R Q +++E + + +
Sbjct: 464 TERHEQERRKQQLKRDQEEERRERWLKLEEEERREQQERREQQLRREQEERREQRLKRQE 523
Query: 198 VEQPFNDSGCLLVDKDLFETGLEDENNSPL--EDEESLESIRAAVKNKVKKHKKKEPSLE 255
E+ L + E+ L E+E+ LE R + K ++ ++++ L+
Sbjct: 524 EEERLQQR---LRSEQQLRREQEERREQLLKREEEKRLEQERREQRLKREQEERRDQLLK 580
Query: 256 SGVHSFEEGSELSKGTTRKERKAARLSKEALKQLHSETQRLIRESALNLPYHMPENKTIH 315
EE + ++ER RL +E +++L E +R R L PE +
Sbjct: 581 RE----EERRQQRLKREQEERLEQRLKREEVERLEQEERREQR-----LKREEPEEERRQ 631
Query: 316 DFFKRKPRPTCHGNAMALLKSSKYQSSHHKEIIDTANTTEMNSDHHSKGSEQTTGAENEV 375
K + + + + + + +E + + +H + EQ AE E
Sbjct: 632 QLLKSEEQEERRQQQLRREQQERREQRLKREEEEERLEQRLKREHEEERREQEL-AEEEQ 690
Query: 376 ETNALPVVSK--ETQIITGSDESCRKDLV-----------KNEELEIQEKQKQSDIRPSP 422
E + S+ + Q S+ R+ V + +E E + ++++S+++
Sbjct: 691 EQARERIKSRIPKWQWQLESEADARQSKVYSRPRKQEGQRRRQEQEEKRRRRESELQWQE 750
Query: 423 GDSSVLQQES-----NFLGNNHSEECQVGG---LVAFEPHALEGEGPQNPEETDEKVEE- 473
+ + QQ+ +F +EE G L A P + E EE ++ +
Sbjct: 751 EERAHRQQQEEEQRRDFTWQWQAEEKSERGRQRLSARPPLREQRERQLRAEERQQREQRF 810
Query: 474 -PEQQNKSSAVGPPEKVRRFTLDRLKQLGVDVSIKPRLGA----DEDSFVILEPETNREL 528
PE++ K + RR L+ L + ++ R A +E+ + + E R
Sbjct: 811 LPEEEEKEQR----RRQRREREKELQFLEEEEQLQRRERAQQLQEEEDGLQEDQERRRSQ 866
Query: 529 EALKQRFWKHANPAAKPRAGQTVNVNVIVKDMGTDGKEELKADVVPVTLAPKKLDGASHT 588
E + + W+ + R T+ ++ E+L+ + + ++L
Sbjct: 867 EQRRDQKWRWQLEEERKRRRHTLYAKPALQ-------EQLRKEQQLLQEEEEELQREERE 919
Query: 589 KPGEKLQVLKAKLQEAMKLRRFEERQKRQALFKLDNEDGFEEEEEEEEEMTDESEEDGEE 648
K + + ++ + R E+ Q+ + + + +E E + D+ + EE
Sbjct: 920 K--------RRRQEQERQYREEEQLQQEEEQLLREEREKRRRQERERQYRKDKKLQQKEE 971
Query: 649 KVEKEEKEEELEEEEEKEEEEEEEGNQETAEFLLSSEEIETKDEKEMDKENND 701
++ EE E+ +E EK+ EEEE QE + L E + E E D
Sbjct: 972 QLLGEEPEKRRRQEREKKYREEEELQQEEEQLLREEREKRRRQEWERQYRKKD 1024
Score = 62.0 bits (149), Expect = 4e-09
Identities = 125/688 (18%), Positives = 264/688 (38%), Gaps = 60/688 (8%)
Query: 43 EGDSDEEIFVSKKLKNRKVLQDSDSETEDTNASPEKTTYDSAEEENKENLYAGKNTKIKR 102
E + E + ++ + ++ Q SE + E+ EE K + ++KR
Sbjct: 510 EQEERREQRLKRQEEEERLQQRLRSEQQLRREQEERREQLLKREEEKRLEQERREQRLKR 569
Query: 103 IYKTVADSDESYMEKSLYQENLEAQVKPCLELSLQSGNSTDFTTD-RKSSKKHIHDKEGT 161
+ D E+ Q+ L+ + + LE L+ + R+ + + E
Sbjct: 570 EQEERRDQLLK-REEERRQQRLKREQEERLEQRLKREEVERLEQEERREQRLKREEPEEE 628
Query: 162 AGKAKVKSKRRLEKEERKMEKIRQLKKKETKNQEDDVEQPFNDSGCLLVDKDLFETGLED 221
+ +KS+ + E+ ++++ + +Q ++++ +E++ E+ +++ L E+
Sbjct: 629 RRQQLLKSEEQEERRQQQLRREQQERREQRLKREEEEER---------LEQRLKREHEEE 679
Query: 222 ENNSPLEDEESLESIRAAVKNKVKKHK----KKEPSLESGVHSFEEGSELSKGTTRKERK 277
L +EE E R +K+++ K + + + +S V+S E + +E K
Sbjct: 680 RREQELAEEEQ-EQARERIKSRIPKWQWQLESEADARQSKVYSRPRKQEGQRRRQEQEEK 738
Query: 278 AARLSKEALKQLHSETQRLIRESALNLPYH---MPENKTIHDFFKRKPRPTCHGNAMALL 334
R E Q R +E + E K+ + RP L
Sbjct: 739 RRRRESELQWQEEERAHRQQQEEEQRRDFTWQWQAEEKSERGRQRLSARPPLREQRERQL 798
Query: 335 KSSKYQSSHHKEIIDTANTTEMNSDHHSKGSE-QTTGAENEVETNALPVVSKETQIITGS 393
++ + Q + + + + + E Q E +++ +E +
Sbjct: 799 RAEERQQREQRFLPEEEEKEQRRRQRREREKELQFLEEEEQLQRRERAQQLQEEEDGLQE 858
Query: 394 DESCRKDLVKNEE------LEIQEKQKQSDIRPSPGDSSVLQQESNFLGNNHSEECQVGG 447
D+ R+ + + LE + K+++ + P L++E L EE Q
Sbjct: 859 DQERRRSQEQRRDQKWRWQLEEERKRRRHTLYAKPALQEQLRKEQQLL-QEEEEELQ--- 914
Query: 448 LVAFEPHALEGEGPQNPEETDEKVEEPEQQNKSSAVGPPEKVRRFTLDRLKQLGVDVSIK 507
E E + E+ + EE + Q + + E+ +R +R +Q D ++
Sbjct: 915 -------REEREKRRRQEQERQYREEEQLQQEEEQLLREEREKRRRQERERQYRKDKKLQ 967
Query: 508 PRLGADEDSFVILEPETNR---------ELEALKQRFWKHANPAAKPRAGQTVNVNVIVK 558
+ E+ + EPE R E E L+Q + + R Q K
Sbjct: 968 QK----EEQLLGEEPEKRRRQEREKKYREEEELQQEEEQLLREEREKRRRQEWERQYRKK 1023
Query: 559 DMGTDGKEEL-KADVVPVTLAPKKLDGASHTKPGEKLQVLKAKLQEAMKLRRFEERQKRQ 617
D +E+L + + L ++ + ++ + L + +E + + E + +++
Sbjct: 1024 DELQQEEEQLLREEREKRRLQERERQYREEEELQQEEEQLLGEERETRRRQELERQYRKE 1083
Query: 618 ALFKLDNEDGFEEEEE-----EEEEMTDESEE--DGEEKVEKEEKEEELEEEEEKEEEEE 670
+ + E EE E E E E EE EE++ +EE+E+ +E E++ EE
Sbjct: 1084 EELQQEEEQLLREEPEKRRRQERERQCREEEELQQEEEQLLREEREKRRRQELERQYREE 1143
Query: 671 EEGNQETAEFLLSSEEIETKDEKEMDKE 698
EE QE + L EE E + +E++++
Sbjct: 1144 EEVQQEEEQLL--REEPEKRRRQELERQ 1169
Score = 61.2 bits (147), Expect = 6e-09
Identities = 207/1225 (16%), Positives = 455/1225 (37%), Gaps = 175/1225 (14%)
Query: 41 LSEGDSDEEIFVSKKLKNRKVLQDSDSETEDTNASPEKTTYDSAEEENKENLYAGKNTKI 100
L+EG+ E ++ L+ D + D ++ + EE E + +
Sbjct: 148 LAEGEEQSE--------KQERLEQRDRQRRDEELWRQRQEWQEREERRAEE----EQLQS 195
Query: 101 KRIYKTVADSDESYMEKSLYQENLEAQVKPCLELSLQSGNSTDFTTDRKSSKKH------ 154
+ ++T DE + + +E LE + K E Q D + K+
Sbjct: 196 CKGHETEEFPDEEQLRR---RELLELRRKGREEKQQQRRERQDRVFQEEEEKEWRKRETV 252
Query: 155 IHDKEGTAGKAKVKSKRRLEKEERKMEKIRQLKKKETKNQEDDVEQPFNDSGCLLVDKDL 214
+ +E + + + +R L++EE ++ K+ + + + + +E+ +Q L ++
Sbjct: 253 LRKEEEKLQEEEPQRQRELQEEEEQLRKLERQELRRERQEEEQQQQRLRREQQLRRKQEE 312
Query: 215 FETGLEDENNSPLEDEESLESIRAA-VKNKVKKHKKKEPSLESGVHSFEEGSELSKGTTR 273
++E E E E R ++ + ++ ++++ E E+ + R
Sbjct: 313 ERREQQEERREQQERREQQEERREQQLRREQEERREQQLRREQEEERREQQLRREQEEER 372
Query: 274 KERKAARLSKEALKQLHSETQRLIRESALNLPYHMPENKTIHDFFKRKPRPTCHGNAMAL 333
+E++ R + +Q Q+L RE L + + + +R+ +
Sbjct: 373 REQQLRREQQLRREQQLRREQQLRREQQLRREQQLRREQQL----RREQQLRREQQLRRE 428
Query: 334 LKSSKYQSSHHKEIIDTANTTEMNSDHHSKGSEQTTGAENEVETNALPVVSKETQIITGS 393
+ +++ H +E + E E+ + E ET ++ Q+
Sbjct: 429 QEEERHEQKHEQERREQRLKREQE--------ERRDWLKREEETERHEQERRKQQLKRDQ 480
Query: 394 DESCRKDLVKNEELEIQEKQKQSDIRPSPGDSSVLQQESNFLGNNHSEECQVGGLVAFEP 453
+E R+ +K EE E +E+Q++ + + ++E E Q +
Sbjct: 481 EEERRERWLKLEEEERREQQERREQQLRREQEE--RREQRLKRQEEEERLQ-------QR 531
Query: 454 HALEGEGPQNPEETDEKVEEPEQQNKSSAVGPPEKVRRFTLDRLKQLGVDVSIKPRLGAD 513
E + + EE E++ + E++ + ++++R +R QL
Sbjct: 532 LRSEQQLRREQEERREQLLKREEEKRLEQERREQRLKREQEERRDQL------------- 578
Query: 514 EDSFVILEPETNRELEALKQRFWKHANPAAKPRAGQTVNVNVIVKDMGTDGKEELKADVV 573
L+ E R + LK+ + K + +V
Sbjct: 579 ------LKREEERRQQRLKREQEERLEQRLK------------------------REEVE 608
Query: 574 PVTLAPKKLDGASHTKPGE--KLQVLKAKLQEAMK---LRRFEERQKRQALFKLDNEDGF 628
+ ++ +P E + Q+LK++ QE + LRR ++ ++ Q L + + E+
Sbjct: 609 RLEQEERREQRLKREEPEEERRQQLLKSEEQEERRQQQLRREQQERREQRLKREEEEERL 668
Query: 629 E-------EEEEEEEEMTDESEEDGEEKVEKE--------EKEEEL-----------EEE 662
E EEE E+E+ +E +E E+++ E E + +E
Sbjct: 669 EQRLKREHEEERREQELAEEEQEQARERIKSRIPKWQWQLESEADARQSKVYSRPRKQEG 728
Query: 663 EEKEEEEEEEGNQETAEFLLSSEEIETKDEKEMDKENN-------DGSSEIGKAVGFLSV 715
+ + +E+EE+ + +E EE + ++E ++ + + SE G+
Sbjct: 729 QRRRQEQEEKRRRRESELQWQEEERAHRQQQEEEQRRDFTWQWQAEEKSERGRQRLSARP 788
Query: 716 PKSLSSDSTLLLFKDSSSKMGYFPTEEKSETDENSGKQPSK----LDEDDSCSLLTKESS 771
P + L + + + P EE+ E ++ K L+E++ L +E +
Sbjct: 789 PLREQRERQLRAEERQQREQRFLPEEEEKEQRRRQRREREKELQFLEEEEQ--LQRRERA 846
Query: 772 HNSSFELIGSTIPSYQPCNRQTGRGTSFFPTAGGFRSPSPGLFRASLVSSASKSSGKLSE 831
E G + +++ R + R R +L + + E
Sbjct: 847 QQLQEEEDGLQEDQERRRSQEQRRDQKWRWQLEEERKRR----RHTLYAKPALQEQLRKE 902
Query: 832 PSLPIEDSQDLYNASPEPKTLFLGAGDFQFCLEDDTQS---QLLDADGFLNVRNHRN-QY 887
L E+ ++L E + + Q+ E+ Q QLL + R R QY
Sbjct: 903 QQLLQEEEEELQREEREKRRR--QEQERQYREEEQLQQEEEQLLREEREKRRRQERERQY 960
Query: 888 QALKPRLPLASMDENAMDANMDELLDLCTGKFTSQAEKHLPRKSDKKENMEELLNLCSGK 947
+ K L +E + ++ + + EK + + ++ E+LL K
Sbjct: 961 RKDKK---LQQKEEQLLGEEPEK-------RRRQEREKKYREEEELQQEEEQLLREEREK 1010
Query: 948 FTSQDASTP--ASSELNKQEKESSMGDPMEEALALCSGSFPTDKEEEDEEEEF-GDFRLV 1004
Q+ EL ++E++ + + L + ++E + EEE+ G+ R
Sbjct: 1011 RRRQEWERQYRKKDELQQEEEQLLREEREKRRLQERERQYREEEELQQEEEQLLGEERET 1070
Query: 1005 SNDNEFDSDEDEHSDSGNDLALEDHEDDDEEELLKRSEKLKRQMRLRKYLEDEAEVSGSD 1064
E + + E+ + ++E+ L + EK +RQ R R+ E+E
Sbjct: 1071 RRRQELERQYRKE---------EELQQEEEQLLREEPEKRRRQERERQCREEEELQQ--- 1118
Query: 1065 VGSEDEYDGEEIDEYEEDVIDEVLPSDEELQSQIKKIHMKTMLDDDKRQLRLYQERYLAD 1124
E++ EE ++ ++ +EE+Q + +++ + + +KR+ + + +Y +
Sbjct: 1119 --EEEQLLREEREKRRRQELERQYREEEEVQQEEEQLLRE---EPEKRRRQELERQYREE 1173
Query: 1125 GDLHSDGPGRMRKFRWKNIDDASQM----DLFHRDSDDDQTEEQLDESEARWRKERIERE 1180
+L + +R+ + K + + + R + ++ S+ +W+ E E+E
Sbjct: 1174 EELQQEEEQLLREEQEKRRQERERQYREEEELQRQKRKQRYRDEDQRSDLKWQWEP-EKE 1232
Query: 1181 QWLRDMAQQGKITAEEEEEIGEDSQ 1205
+RD K E+ EDSQ
Sbjct: 1233 NAVRDNKVYCKGRENEQFRQLEDSQ 1257
Score = 56.2 bits (134), Expect = 2e-07
Identities = 71/316 (22%), Positives = 129/316 (40%), Gaps = 36/316 (11%)
Query: 391 TGSDESCRKDLVKNEELEIQEKQKQSDIRPSPGDSSVLQQESNFLGNNHSEECQVGGLVA 450
TG DE R E L +Q++ R P D + ++ E+
Sbjct: 93 TGLDEEKRARCDGKESLLQDRRQEEDQRRFEPRDRQLEEEPGQRRRQKRQEQ-------- 144
Query: 451 FEPHALEGEGPQNPEETDEKVEEPEQQNKSSAVGPPEKVRRFTLDRLKQLGVDVSIKPRL 510
E EGE E EK E EQ+++ + R+ +R ++ + ++
Sbjct: 145 -ERELAEGE------EQSEKQERLEQRDRQRRDEELWRQRQEWQEREERRAEEEQLQSCK 197
Query: 511 GADEDSFVILEPETNRELEALKQRFWKHANPAAKPRAGQTVNVNVIVKDMGTDGKEELKA 570
G + + F E REL L+++ + + R + +EE K
Sbjct: 198 GHETEEFPDEEQLRRRELLELRRKGREEKQQQRRERQDRVFQ------------EEEEKE 245
Query: 571 DVVPVTLAPKKLDGASHTKPG-------EKLQVLKAKLQEAMKLRRFEERQKRQALFKLD 623
T+ K+ + +P E+ Q+ K + QE ++ R EE Q++Q L +
Sbjct: 246 WRKRETVLRKEEEKLQEEEPQRQRELQEEEEQLRKLERQE-LRRERQEEEQQQQRLRREQ 304
Query: 624 N-EDGFEEEEEEEEEMTDESEEDGEEKVEKEEKEEELEEEEEKEEEEEEEGNQETAEFLL 682
EEE E++E E +E E++ E+ E++ E+EE +E++ E +E E L
Sbjct: 305 QLRRKQEEERREQQEERREQQERREQQEERREQQLRREQEERREQQLRREQEEERREQQL 364
Query: 683 SSEEIETKDEKEMDKE 698
E+ E + E+++ +E
Sbjct: 365 RREQEEERREQQLRRE 380
Score = 50.4 bits (119), Expect = 1e-05
Identities = 132/708 (18%), Positives = 272/708 (38%), Gaps = 76/708 (10%)
Query: 30 SGQGSYETIGPLSEGDSDEEIFVSKKLKNRKVLQDSDSETEDTNASPEKTTYDSAEEENK 89
S Q +G E D ++E ++ ++R ++ E E+ + + D +E K
Sbjct: 1263 SQQDLQHLLGEQQERDREQERRRWQQ-RDRHFPEEEQLEREEQKEAKRR---DRKSQEEK 1318
Query: 90 ENLYAGKNTKIKRIYKTVADSDESYMEKSLYQENLEAQVKPCLELSLQSGNSTDFTTDRK 149
+ L + K +R ++D + E+ + E Q E DRK
Sbjct: 1319 QLLREEREEKRRR-----QETDRKFREEEQLLQEREEQPLRRQE------------RDRK 1361
Query: 150 SSKKHI-HDKEGTAGKAKVKSKRRLEKEERKMEKIRQLKKKETKNQ-EDDVEQPFNDSGC 207
++ + H ++G + + RR E+E + +++ +QL+ +E + Q D ++ F +
Sbjct: 1362 FREEELRHQEQGRKFLEEEQRLRRQERERKFLKEEQQLRCQEREQQLRQDRDRKFREEEQ 1421
Query: 208 LLVDKDLFETGLEDENNSPLEDEES--LESIRAAVKNKVKKHKKKEPSL----ESGVHSF 261
L ++ E+E ++ E LE + + + +K +++E L E +H
Sbjct: 1422 QLSRQERDRKFREEEQQVRRQERERKFLEEEQQLRQERHRKFREEEQLLQEREEQQLHRQ 1481
Query: 262 EEGSEL--SKGTTRKERKAARLSKEALKQLHSETQRLIRESALNLPYHMPENKTIHDFFK 319
E + + R++ + + ++ L+ E + L E L+ + +
Sbjct: 1482 ERDRKFLEEEQQLRRQERDRKFREQELRSQEPERKFLEEEQQLHRQQRQRKFLQEEQQLR 1541
Query: 320 RKPRPTCHGNAMALLKSSKYQSSHH-KEIIDTANTTEMNSDHHSKGSEQTTGAENEV--- 375
R+ R G + K++ ++ + + D + EQ + +
Sbjct: 1542 RQER----GQQRRQDRDRKFREEEQLRQEREEQQLSRQERDRKFRLEEQKVRRQEQERKF 1597
Query: 376 --ETNALPVVSKETQIITGSDESCRKDLVKNEELEIQEKQKQSDIRPSPGDSSVLQQESN 433
+ L + Q+ D R+D +E E Q+ +Q R + L+++
Sbjct: 1598 MEDEQQLRRQEGQQQLRQERDRKFREDEQLLQEREEQQLHRQERDRKFLEEEPQLRRQER 1657
Query: 434 FLGNNHSEECQVGGLVAFEPHALEGEGPQ-NPEETDEKVEEPEQQNKSSAVGPPEKVRRF 492
H + + E EGE Q +E D K E EQQ + E+ R+F
Sbjct: 1658 EQQLRHDRDRKFR---EEEQLLQEGEEQQLRRQERDRKFREEEQQLRRQ-----ERERKF 1709
Query: 493 TLDRLKQLGVDVSIKPRLGADEDSFVILEPETNRELEALKQRFWKHANPAAKPRAGQTVN 552
+ + ++ K R +E+ L ET +E ++R+ K +
Sbjct: 1710 LQEEQQLRRQELERKFR---EEEQ---LRQETEQEQLRRQERYRKILEEEQLRPEREEQQ 1763
Query: 553 VNVIVKDMGTDGKEELKADVVPVTLAPKKLDGASHTKPGEKLQVLKAKLQEAMKLRRFEE 612
+ +D +E+L+ + L ++ D K +E +LR+ E
Sbjct: 1764 LRRQERDRKFREEEQLRQEREEQQLRSQESD---------------RKFREEEQLRQERE 1808
Query: 613 RQKRQALFKLDNEDGFEEEEEEEEEMTDESEEDGEEKVEKEEK----EEELEEEEEKEEE 668
Q+ + + D + +EEE+ + EE ++ + + EE+ E+ EE+E +E
Sbjct: 1809 EQQLRPQQR-DGKYRWEEEQLQLEEQEQRLRQERDRQYRAEEQFATQEKSRREEQELWQE 1867
Query: 669 EEEEGNQETAEFLLSSEEIETKDEKEMDKENNDGSSEIGKAVGFLSVP 716
EE++ QE L + E++ ++ + S+ GK G L P
Sbjct: 1868 EEQKRRQERERKLREEHIRRQQKEEQRHRQVGEIKSQEGKGHGRLLEP 1915
Score = 47.8 bits (112), Expect = 7e-05
Identities = 119/621 (19%), Positives = 237/621 (38%), Gaps = 74/621 (11%)
Query: 143 DFTTDRKSSKKHIHDKEGTAGKAKVKSKR--RLEKEERKMEKIRQLKKKETKNQ------ 194
DFT ++ +K ++ + + ++ +R +L EER+ + R L ++E K Q
Sbjct: 766 DFTWQWQAEEKSERGRQRLSARPPLREQRERQLRAEERQQREQRFLPEEEEKEQRRRQRR 825
Query: 195 EDDVEQPFNDSGCLLVDKDLFETGLEDENNSPLEDEESLESIRAAVKNK----VKKHKKK 250
E + E F + L ++ + L++E + ED+E S K +++ +K+
Sbjct: 826 EREKELQFLEEEEQLQRRERAQQ-LQEEEDGLQEDQERRRSQEQRRDQKWRWQLEEERKR 884
Query: 251 -------EPSLESGVHSF-----EEGSELSKGTTRKERKAARLSK-EALKQLHSETQRLI 297
+P+L+ + EE EL + K R+ + + +QL E ++L+
Sbjct: 885 RRHTLYAKPALQEQLRKEQQLLQEEEEELQREEREKRRRQEQERQYREEEQLQQEEEQLL 944
Query: 298 RESALNLPYHMPENKTIHDFFKRKPRPTCHGNAMALLKSSKYQSSHHKEIIDTANTTEMN 357
RE E + D ++ G + + + + +E ++
Sbjct: 945 REEREKRRRQERERQYRKDKKLQQKEEQLLGEEPEKRRRQEREKKYREEEELQQEEEQLL 1004
Query: 358 SDHHSKGSEQTTGAENEVETNALPVVSKETQIITGSDESCR-----KDLVKNEELEIQEK 412
+ K Q + + + +E Q++ E R + + EEL+ +E+
Sbjct: 1005 REEREKRRRQEWERQYRKKDE---LQQEEEQLLREEREKRRLQERERQYREEEELQQEEE 1061
Query: 413 Q---------KQSDIRPSPGDSSVLQQESNFLGNNHSEEC--QVGGLVAFEPHALEGEGP 461
Q ++ ++ LQQE L E+ Q E L+ E
Sbjct: 1062 QLLGEERETRRRQELERQYRKEEELQQEEEQLLREEPEKRRRQERERQCREEEELQQEEE 1121
Query: 462 QNPEETDEK------------VEEPEQQNKSSAVGPPEKVRRFTLDRLKQLGVDVSIKPR 509
Q E EK EE +Q+ + PEK RR L+R +
Sbjct: 1122 QLLREEREKRRRQELERQYREEEEVQQEEEQLLREEPEKRRRQELER------QYREEEE 1175
Query: 510 LGADEDSFVILEPETNRELEALKQRFWKHANPAAKPRAGQTVNVNVIVKDMGTDGKEELK 569
L +E+ + E E R+ ++R ++ + + Q D+ + E +
Sbjct: 1176 LQQEEEQLLREEQEKRRQE---RERQYREEEELQRQKRKQRYRDEDQRSDLKWQWEPEKE 1232
Query: 570 ADVVPVTLAPKKLDGA-------SHTKPGEKLQVLKAKLQEAMKLRRFEERQKRQALFK- 621
V + K + S + + Q L+ L E + R +ER++ Q +
Sbjct: 1233 NAVRDNKVYCKGRENEQFRQLEDSQLRDRQSQQDLQHLLGEQQERDREQERRRWQQRDRH 1292
Query: 622 LDNEDGFEEEEEEEEEMTDESEEDGEEKVEKEEKEEELEEEEEKEEEEEEEGNQETAEFL 681
E+ E EE++E + D ++ ++ + +E +E+ +E +++ EEE+ QE E
Sbjct: 1293 FPEEEQLEREEQKEAKRRDRKSQEEKQLLREEREEKRRRQETDRKFREEEQLLQEREEQP 1352
Query: 682 LSSEEIETKDEKEMDKENNDG 702
L +E + K +E + G
Sbjct: 1353 LRRQERDRKFREEELRHQEQG 1373
Score = 47.0 bits (110), Expect = 1e-04
Identities = 53/242 (21%), Positives = 101/242 (41%), Gaps = 37/242 (15%)
Query: 989 KEEED--EEEEFGDFRLVSNDNEFDSDEDEHSDSGNDLALEDHEDDDEEELLKRSEKLKR 1046
+EEE +E E R D +F +E H + G + L+ ++L+R
Sbjct: 1339 REEEQLLQEREEQPLRRQERDRKFREEELRHQEQGR-------------KFLEEEQRLRR 1385
Query: 1047 QMRLRKYLEDEAEVSGSDVGSEDEYDGEEIDEYEEDVI--DEVLPSDEELQSQIKKIHMK 1104
Q R RK+L++E ++ + + D + EE + E E + Q+++ +
Sbjct: 1386 QERERKFLKEEQQLRCQEREQQLRQDRDRKFREEEQQLSRQERDRKFREEEQQVRRQERE 1445
Query: 1105 TMLDDDKRQLRLYQERYLADGDLHSDGPGRMRKFRWKN--IDDASQMDLFHRDSDDDQTE 1162
++++QLR QER+ RKFR + + + + L ++ D E
Sbjct: 1446 RKFLEEEQQLR--QERH--------------RKFREEEQLLQEREEQQLHRQERDRKFLE 1489
Query: 1163 EQLDESEARWRKERIEREQWLRDMAQQGKITAEEEEEIGEDSQFMILAKKVTAKALQKNA 1222
E ++ R ++R REQ LR + K EE++ + Q L ++ + ++
Sbjct: 1490 E--EQQLRRQERDRKFREQELRSQEPERKFLEEEQQLHRQQRQRKFLQEEQQLRRQERGQ 1547
Query: 1223 SR 1224
R
Sbjct: 1548 QR 1549
Score = 45.4 bits (106), Expect = 4e-04
Identities = 51/236 (21%), Positives = 100/236 (42%), Gaps = 22/236 (9%)
Query: 989 KEEEDEE--EEFGDFRLVSNDNEFDSDEDEHSDSGNDLALEDHED-----DDEEELLKRS 1041
++E D + EE R + + D D L E E + + + +
Sbjct: 1638 RQERDRKFLEEEPQLRRQEREQQLRHDRDRKFREEEQLLQEGEEQQLRRQERDRKFREEE 1697
Query: 1042 EKLKRQMRLRKYLEDEAEVSGSDVGSEDEYDGEEIDEYEEDVI------------DEVLP 1089
++L+RQ R RK+L++E ++ ++ + + + E E++ + +++ P
Sbjct: 1698 QQLRRQERERKFLQEEQQLRRQELERKFREEEQLRQETEQEQLRRQERYRKILEEEQLRP 1757
Query: 1090 SDEELQSQIKKIHMKTMLDDDKRQLRLYQERYLADGDLHSDGPGRMRKFRWKNIDDASQM 1149
EE Q + ++ K ++ RQ R Q+ + D ++R+ R + Q
Sbjct: 1758 EREEQQLRRQERDRKFREEEQLRQEREEQQLRSQESDRKFREEEQLRQEREEQQLRPQQR 1817
Query: 1150 DLFHRDSDDDQTEEQLDESEARWRKERIEREQWLRDMAQQGKITAEEEEEIGEDSQ 1205
D +R ++ + QL+E E R R+ER + + A Q K EE+E E+ Q
Sbjct: 1818 DGKYRWEEE---QLQLEEQEQRLRQERDRQYRAEEQFATQEKSRREEQELWQEEEQ 1870
Score = 42.7 bits (99), Expect = 0.002
Identities = 51/236 (21%), Positives = 100/236 (42%), Gaps = 18/236 (7%)
Query: 975 EEALALCSG--SFPTDKEEEDEEEEFGDFRLVSNDNEFDSDEDEHSDSGNDLALEDHEDD 1032
EE A C G S D+ +E+++ F + + + +LA E E
Sbjct: 97 EEKRARCDGKESLLQDRRQEEDQRRFEPRDRQLEEEPGQRRRQKRQEQERELA-EGEEQS 155
Query: 1033 DEEELLKRSEKLKRQMRLRKYLED--EAEVSGSDVGSEDEYDGEEIDEYEEDVIDEVLPS 1090
+++E L++ ++ +R L + ++ E E ++ G E +E+ DE
Sbjct: 156 EKQERLEQRDRQRRDEELWRQRQEWQEREERRAEEEQLQSCKGHETEEFP----DEEQLR 211
Query: 1091 DEELQSQIKKIHMKTMLDDDKRQLRLYQERYLADGDLHSDGPGRMRKFRWKNIDDASQMD 1150
EL +K + +RQ R++QE + R R+ + ++ Q +
Sbjct: 212 RRELLELRRKGREEKQQQRRERQDRVFQEE--------EEKEWRKRETVLRKEEEKLQEE 263
Query: 1151 LFHRDSDDDQTEEQLDESEAR-WRKERIEREQWLRDMAQQGKITAEEEEEIGEDSQ 1205
R + + EEQL + E + R+ER E EQ + + ++ ++ ++EEE E +
Sbjct: 264 EPQRQRELQEEEEQLRKLERQELRRERQEEEQQQQRLRREQQLRRKQEEERREQQE 319
Score = 40.0 bits (92), Expect = 0.015
Identities = 56/288 (19%), Positives = 116/288 (40%), Gaps = 32/288 (11%)
Query: 922 QAEKHLPRKSDKKENMEELLNLCSGKFTSQDASTPASSELNKQEKESSMGDPMEEALALC 981
Q E+ L R+ +K +E C ++ +L ++E+E +E
Sbjct: 1088 QEEEQLLREEPEKRRRQERERQCR----EEEELQQEEEQLLREEREKRRRQELERQYR-- 1141
Query: 982 SGSFPTDKEEEDEEEEFGDFRLVSNDNEFDSDEDEHSDSGNDLALEDHEDDDEEELLKRS 1041
++EE +EEE +L+ + E + + E+ +EE+LL+
Sbjct: 1142 ------EEEEVQQEEE----QLLREEPE----KRRRQELERQYREEEELQQEEEQLLREE 1187
Query: 1042 EKLKRQMRLRKYLEDEAEVSGSDVGSEDEYDGEEIDEYEEDVIDEVLPSDEELQSQIKKI 1101
++ +RQ R R+Y E+E + D +++ + E D ++ + ++
Sbjct: 1188 QEKRRQERERQYREEEELQRQKRKQRYRDEDQRSDLKWQWEPEKENAVRDNKVYCKGREN 1247
Query: 1102 HMKTMLDDDKRQLRLYQE--RYLADGDLHSDGPGRMRKFRWKNIDDASQMDLFHRDSDDD 1159
L+D + + R Q+ ++L D R RW+ D H ++
Sbjct: 1248 EQFRQLEDSQLRDRQSQQDLQHLLGEQQERDREQERR--RWQQRDR-------HFPEEEQ 1298
Query: 1160 QTEEQLDESEARWRKERIEREQWLRDMAQQGKITAEEEEEIGEDSQFM 1207
E+ E++ R RK + E +Q LR+ ++ + E + + E+ Q +
Sbjct: 1299 LEREEQKEAKRRDRKSQ-EEKQLLREEREEKRRRQETDRKFREEEQLL 1345
Score = 40.0 bits (92), Expect = 0.015
Identities = 63/302 (20%), Positives = 129/302 (42%), Gaps = 43/302 (14%)
Query: 1002 RLVSNDNEFDSDEDEHSDSGNDLALEDHED----DDEEELLKRSEK-LKRQMRLRKYLED 1056
R + +F DE + L D +DE+ L +R E+ L RQ R RK+LE+
Sbjct: 1589 RRQEQERKFMEDEQQLRRQEGQQQLRQERDRKFREDEQLLQEREEQQLHRQERDRKFLEE 1648
Query: 1057 EAEVSGSDVGSEDEYDGEEIDEYEEDVIDEVLPS------------DEELQSQIKKIHMK 1104
E ++ + + +D + EE ++ E +EE Q + ++ K
Sbjct: 1649 EPQLRRQEREQQLRHDRDRKFREEEQLLQEGEEQQLRRQERDRKFREEEQQLRRQERERK 1708
Query: 1105 TMLDDDKRQLRLYQERYLADGDLHSDGPGRM--RKFRWKNIDDASQM-------DLFHRD 1155
+ ++ + + + + ++ + L + R+ R++ I + Q+ L ++
Sbjct: 1709 FLQEEQQLRRQELERKFREEEQLRQETEQEQLRRQERYRKILEEEQLRPEREEQQLRRQE 1768
Query: 1156 SD----------DDQTEEQL--DESEARWRKE---RIER-EQWLRDMAQQGKITAEEEE- 1198
D ++ E+QL ES+ ++R+E R ER EQ LR + GK EEE+
Sbjct: 1769 RDRKFREEEQLRQEREEQQLRSQESDRKFREEEQLRQEREEQQLRPQQRDGKYRWEEEQL 1828
Query: 1199 EIGEDSQFMILAKKVTAKALQKNASRPMVIQESKSLLRNPFEAIRPGSAQQVKTGSLLNQ 1258
++ E Q + + +A ++ A++ +E + L + + R ++++ + Q
Sbjct: 1829 QLEEQEQRLRQERDRQYRAEEQFATQEKSRREEQELWQEEEQKRRQERERKLREEHIRRQ 1888
Query: 1259 PK 1260
K
Sbjct: 1889 QK 1890
Score = 34.7 bits (78), Expect = 0.63
Identities = 21/102 (20%), Positives = 52/102 (50%), Gaps = 5/102 (4%)
Query: 600 KLQEAMKLRRFEERQKRQALFKLDNEDGFEEEEEEEEEMTDESEEDGEEKVEKEEKEEEL 659
+L+E RR ++RQ+++ + +G EE+ E++E + + +E++ ++ +E +
Sbjct: 128 QLEEEPGQRRRQKRQEQER----ELAEG-EEQSEKQERLEQRDRQRRDEELWRQRQEWQE 182
Query: 660 EEEEEKEEEEEEEGNQETAEFLLSSEEIETKDEKEMDKENND 701
EE EEE+ + E E++ ++ E+ ++ +
Sbjct: 183 REERRAEEEQLQSCKGHETEEFPDEEQLRRRELLELRRKGRE 224
Score = 32.7 bits (73), Expect = 2.4
Identities = 20/86 (23%), Positives = 40/86 (46%), Gaps = 7/86 (8%)
Query: 620 FKLDNEDGFEEEEE-----EEEEMTDESEEDGEEKVEKEEK--EEELEEEEEKEEEEEEE 672
+ L G +EE+ +E + D +E+ + + E ++ EEE + ++ +E+E
Sbjct: 87 YALGQATGLDEEKRARCDGKESLLQDRRQEEDQRRFEPRDRQLEEEPGQRRRQKRQEQER 146
Query: 673 GNQETAEFLLSSEEIETKDEKEMDKE 698
E E E +E +D + D+E
Sbjct: 147 ELAEGEEQSEKQERLEQRDRQRRDEE 172
Score = 31.6 bits (70), Expect = 5.3
Identities = 17/81 (20%), Positives = 39/81 (48%)
Query: 625 EDGFEEEEEEEEEMTDESEEDGEEKVEKEEKEEELEEEEEKEEEEEEEGNQETAEFLLSS 684
+D +EE++ E D E+ + +++++E+ E E EE+ E++ E +
Sbjct: 111 QDRRQEEDQRRFEPRDRQLEEEPGQRRRQKRQEQERELAEGEEQSEKQERLEQRDRQRRD 170
Query: 685 EEIETKDEKEMDKENNDGSSE 705
EE+ + ++ ++E E
Sbjct: 171 EELWRQRQEWQEREERRAEEE 191
Score = 31.2 bits (69), Expect = 7.0
Identities = 37/177 (20%), Positives = 72/177 (40%), Gaps = 9/177 (5%)
Query: 1029 HEDDDEEELLKRSEKLKRQMRLRKYLEDEAEVSGSDVGSEDEYDGEEIDEYEEDVIDEVL 1088
H + + + L+ ++L+RQ R RK+ E E E ++ EE + + + L
Sbjct: 1479 HRQERDRKFLEEEQQLRRQERDRKFREQELR----SQEPERKFLEEEQQLHRQQRQRKFL 1534
Query: 1089 PSDEELQSQIKKIHMKTMLDDDKRQLRLYQERYLADGDLHSDGPGRMRKFRWKNIDDASQ 1148
+++L+ Q + + D R+ R ++ + R RKFR + Q
Sbjct: 1535 QEEQQLRRQERGQQRR---QDRDRKFREEEQLRQEREEQQLSRQERDRKFRLEEQKVRRQ 1591
Query: 1149 MDLFHRDSDDDQTEEQLDESEARWRKER--IEREQWLRDMAQQGKITAEEEEEIGED 1203
D+ Q Q + + R ++R E EQ L++ +Q E + + E+
Sbjct: 1592 EQERKFMEDEQQLRRQEGQQQLRQERDRKFREDEQLLQEREEQQLHRQERDRKFLEE 1648
>gi|32483416 neurofilament, heavy polypeptide 200kDa [Homo sapiens]
Length = 1020
Score = 66.6 bits (161), Expect = 1e-10
Identities = 133/670 (19%), Positives = 255/670 (38%), Gaps = 101/670 (15%)
Query: 46 SDEEIFVSKKLKNRKVLQDSDSETEDTNASPEKTTYDSAEEENKENLYAGKNTKIKRIYK 105
S+E+I V +K + V+ + +TE+T + E T EEE KE
Sbjct: 440 SEEKIKVVEKSEKETVIVEE--QTEETQVTEEVT-----EEEEKE--------------- 477
Query: 106 TVADSDESYMEKSLYQENLEAQVKPCLELSLQSGNSTDFTTDRKSSKKHIHDKEGTAGKA 165
A +E E+ +E E E +S + + + K +K + ++ + +A
Sbjct: 478 --AKEEEGKEEEGGEEEEAEGG-----EEETKSPPAEEAASPEKEAKSPVKEEAKSPAEA 530
Query: 166 KVKSKRRLEK--EERKMEKIRQLKKKETKNQED--DVEQPFNDSGCLLVDKDLFETGLED 221
K K + E + EK + K+E K+ + E+ S + + ++ ++
Sbjct: 531 KSPEKEEAKSPAEVKSPEKAKSPAKEEAKSPPEAKSPEKEEAKSPAEVKSPEKAKSPAKE 590
Query: 222 ENNSPLEDEESLESIRAAVKNKVKKHKK-KEPSLESGVHSFEEGS-ELSKGTTRKERKAA 279
E SP E +S E ++ VK + K + K P E E S E +K T++E K+
Sbjct: 591 EAKSPAE-AKSPEKAKSPVKEEAKSPAEAKSPVKEEAKSPAEVKSPEKAKSPTKEEAKSP 649
Query: 280 RLSKEALKQLHSETQRLIRESALNLPYHMPENKTIHDFFKRKPRPTCHGNAMALLKSSKY 339
+K K+ ++ +S + PE + P A KS +
Sbjct: 650 EKAKSPEKEEAKSPEKA--KSPVKAEAKSPEKA-------KSP-------VKAEAKSPEK 693
Query: 340 QSSHHKEIIDTANTTEMNSDHHSKGSEQTTGAENEVETNALPVVSKETQIITGSDESCRK 399
S KE + + +K E+ A V +E + + ++
Sbjct: 694 AKSPVKEEAKSPEKAKSPVKEEAKSPEK-----------AKSPVKEEAKTPEKAKSPVKE 742
Query: 400 DLVKNEELEIQEKQKQSDIRPSPGDSSVLQQESNFLGNNHSEECQVGGLVAFEPHALEGE 459
+ E+ + EK K D++ SP + ++E+ + E+ + + E
Sbjct: 743 EAKSPEKAKSPEKAKTLDVK-SPEAKTPAKEEARSPADKFPEKAKS----PVKEEVKSPE 797
Query: 460 GPQNPEETDEKVEEPEQQNKSSAVGPPEKVRRFTLDRLKQLGVDVSIKPRLGADEDSFVI 519
++P + D K E E K P ++ ++ +V +K E+
Sbjct: 798 KAKSPLKEDAKAPEKEIPKKEEVKSPVKE---------EEKPQEVKVKEPPKKAEEEKAP 848
Query: 520 LEPETNRELEALKQRFWKHANPAAKPRAGQTVNVNVIVKDMGTDGKEELKADV----VPV 575
P+T + ++ K+ K P K + V K+ + K+E D P
Sbjct: 849 ATPKTEEKKDSKKEEAPKKEAPKPKVEEKKEPAVEK-PKESKVEAKKEEAEDKKKVPTPE 907
Query: 576 TLAPKKLDGASHTKPGEKLQVLKAKLQEAMKLRRFEERQKRQALFKLDNEDGFEEEEEEE 635
AP K++ KP EK +V K + +A + +K++A E+++ +
Sbjct: 908 KEAPAKVEVKEDAKPKEKTEVAKKEPDDAKAKEPSKPAEKKEAA---------PEKKDTK 958
Query: 636 EEMTDESEEDGEEKVEKEEKEEELEEEEEKEEEEEEEGNQETAEFLLSSEEIETKDEKEM 695
EE + EE + + + +E ++ L +E K + E+ E + T + KD K
Sbjct: 959 EEKAKKPEEKPKTEAKAKEDDKTLSKEPSKPKAEKAEKSSST----------DQKDSKPP 1008
Query: 696 DKENNDGSSE 705
+K D +++
Sbjct: 1009 EKATEDKAAK 1018
Score = 52.0 bits (123), Expect = 4e-06
Identities = 120/579 (20%), Positives = 206/579 (35%), Gaps = 51/579 (8%)
Query: 220 EDENNSPLEDEESLESIRAAVKNKVKKHKKKEPSLESGVHSFEEGSELSKGTTRKERKAA 279
+ E + + +E++ E+ V +V + ++KE E G EEG E + +E +
Sbjct: 449 KSEKETVIVEEQTEET---QVTEEVTEEEEKEAKEEEGKE--EEGGEEEEAEGGEEETKS 503
Query: 280 RLSKEALKQLHSETQRLIRESALNLPYHMPENKTIHDFFKRKPRPTCHGNAMALLKSSKY 339
++EA + E+ PE + + K A KS
Sbjct: 504 PPAEEAASPEKEAKSPVKEEAKSPAEAKSPEKEEAKSPAEVKSPEKAKSPAKEEAKSPPE 563
Query: 340 QSSHHKEIIDTANTTEMNSDHHSKG---SEQTTGAENEVETNALPVVSKETQIITGSDES 396
S KE + + E+ S +K E + AE + A V +E + +
Sbjct: 564 AKSPEKE--EAKSPAEVKSPEKAKSPAKEEAKSPAEAKSPEKAKSPVKEEAKSPAEAKSP 621
Query: 397 CRKDLVKNEELEIQEKQKQSDIRPSPGDSSVLQQESNFLGNNHSEECQVGGLV-----AF 451
+++ E++ EK K + E + + V A
Sbjct: 622 VKEEAKSPAEVKSPEKAKSPTKEEAKSPEKAKSPEKEEAKSPEKAKSPVKAEAKSPEKAK 681
Query: 452 EPHALEGEGPQNPEE-TDEKVEEPEQQN---KSSAVGP-----PEKVRRFTLDRLKQLGV 502
P E + P+ + E+ + PE+ K A P P K T ++ K
Sbjct: 682 SPVKAEAKSPEKAKSPVKEEAKSPEKAKSPVKEEAKSPEKAKSPVKEEAKTPEKAKSPVK 741
Query: 503 DVSIKPRLGADEDSFVILEPETNRELEALKQRFWKHANPAAKPRAGQTVNVNVIVKDMGT 562
+ + P + L+ ++ K+ + +PA K V VK
Sbjct: 742 EEAKSPEKAKSPEKAKTLDVKSPEAKTPAKE---EARSPADKFPEKAKSPVKEEVKSP-E 797
Query: 563 DGKEELKADV-VPVTLAPKKLDGASHTKPGEKLQVLKAK---------------LQEAMK 606
K LK D P PKK + S K EK Q +K K E K
Sbjct: 798 KAKSPLKEDAKAPEKEIPKKEEVKSPVKEEEKPQEVKVKEPPKKAEEEKAPATPKTEEKK 857
Query: 607 LRRFEERQKRQA---LFKLDNEDGFEEEEEEEEEMTDESEEDGEEKVEKEEKEE--ELEE 661
+ EE K++A + E E+ +E + E E ED ++KV EKE ++E
Sbjct: 858 DSKKEEAPKKEAPKPKVEEKKEPAVEKPKESKVEAKKEEAED-KKKVPTPEKEAPAKVEV 916
Query: 662 EEEKEEEEEEEGNQETAEFLLSSEEIETKDEKEMDKENNDGSSEIGKAVGFLSVPKSLSS 721
+E+ + +E+ E ++ + + E + ++KE E D E K ++ +
Sbjct: 917 KEDAKPKEKTEVAKKEPDDAKAKEPSKPAEKKEAAPEKKDTKEEKAKKPEEKPKTEAKAK 976
Query: 722 DSTLLLFKDSSSKMGYFPTEEKSETDENSGKQPSKLDED 760
+ L K+ S E+ S TD+ K P K ED
Sbjct: 977 EDDKTLSKEPSKPKAE-KAEKSSSTDQKDSKPPEKATED 1014
Score = 51.2 bits (121), Expect = 7e-06
Identities = 43/166 (25%), Positives = 75/166 (45%), Gaps = 13/166 (7%)
Query: 609 RFEERQKRQALFKLDNEDGFEEEEEEEEEMTDESEEDGEEKVEKEEKEEELEEEEEKEEE 668
+ + +K + + K + E EE+ EE ++T+E E+ E++ ++EE +EE EEE+ E
Sbjct: 437 KVKSEEKIKVVEKSEKETVIVEEQTEETQVTEEVTEEEEKEAKEEEGKEEEGGEEEEAEG 496
Query: 669 EEEEGNQETAEFLLSSE---EIETKDEKEMDKENNDGSSEIGKAVGFLSVPKSLSSDSTL 725
EEE AE S E + K+E + E E K+ + P+ S +
Sbjct: 497 GEEETKSPPAEEAASPEKEAKSPVKEEAKSPAEAKSPEKEEAKSPAEVKSPEKAKSPA-- 554
Query: 726 LLFKDSSSKMGYFPTEEKSETDENSGKQPSKLDEDDSCSLLTKESS 771
K+ + P E KS E + K P+++ + KE +
Sbjct: 555 ---KEEAKS----PPEAKSPEKEEA-KSPAEVKSPEKAKSPAKEEA 592
Score = 49.7 bits (117), Expect = 2e-05
Identities = 95/487 (19%), Positives = 178/487 (36%), Gaps = 59/487 (12%)
Query: 21 QEEADSPSDSGQGSYETIGPLSEGDSDEEIFVSKKLKNRKVLQDSDSETEDTNA-----S 75
+EEA SP+++ E +E S E+ K + + + E E+ + S
Sbjct: 521 KEEAKSPAEAKSPEKEEAKSPAEVKSPEKAKSPAKEEAKSPPEAKSPEKEEAKSPAEVKS 580
Query: 76 PEKTTYDSAEEENKENLYAGKNTKIKRIYKTVADSDESYMEKSLYQENLEAQVK------ 129
PEK A+EE K A K K K A S + A+VK
Sbjct: 581 PEKAK-SPAKEEAKSPAEAKSPEKAKSPVKEEAKSPAEAKSPVKEEAKSPAEVKSPEKAK 639
Query: 130 -PCLELSLQSGNSTDFTTDRKSSKKHIHDKEGTAGKAKVKSKRRLEKEERKMEKIRQLKK 188
P E + + + S + K+ K+K ++ E + EK + K
Sbjct: 640 SPTKEEAKSPEKAKSPEKEEAKSPEKAKSPVKAEAKSPEKAKSPVKAEAKSPEKAKSPVK 699
Query: 189 KETKNQEDDVEQPFNDSGCLLVDKDLFETGLEDENNSP-------LEDEESLESIRAAVK 241
+E K+ E + P + + ++ +++E +P E+ +S E ++ K
Sbjct: 700 EEAKSPE-KAKSPVKEEA---KSPEKAKSPVKEEAKTPEKAKSPVKEEAKSPEKAKSPEK 755
Query: 242 NK---VKKHKKKEPSLESGVHSFEEGSELSKGTTRKERKAARLSKEALKQLHSETQRLIR 298
K VK + K P+ E ++ E +K ++E K+ +K LK
Sbjct: 756 AKTLDVKSPEAKTPAKEEARSPADKFPEKAKSPVKEEVKSPEKAKSPLK----------- 804
Query: 299 ESALNLPYHMPENKTIHDFFKRKPRPTCHGNAMALLKSSKYQSSHHKEIIDTANTTEMNS 358
E A +P+ + + K + +P +K + +E TE
Sbjct: 805 EDAKAPEKEIPKKEEVKSPVKEEEKP-------QEVKVKEPPKKAEEEKAPATPKTEEKK 857
Query: 359 DHHSKGSEQTTGAENEVETNALPVVS--KETQIITGSDESCRKDLVKNEELEIQEK-QKQ 415
D + + + + +VE P V KE+++ +E+ K V E E K + +
Sbjct: 858 DSKKEEAPKKEAPKPKVEEKKEPAVEKPKESKVEAKKEEAEDKKKVPTPEKEAPAKVEVK 917
Query: 416 SDIRPSPGDSSVLQQESNFLGNNHSEECQVGGLVAFEPHALEGEGPQNPEETDEKVEEPE 475
D +P ++ + S +P + P+ + +EK ++PE
Sbjct: 918 EDAKPKEKTEVAKKEPDDAKAKEPS-----------KPAEKKEAAPEKKDTKEEKAKKPE 966
Query: 476 QQNKSSA 482
++ K+ A
Sbjct: 967 EKPKTEA 973
Score = 44.3 bits (103), Expect = 8e-04
Identities = 38/169 (22%), Positives = 76/169 (44%), Gaps = 5/169 (2%)
Query: 589 KPGEKLQVLKAKLQEAMKLR-RFEERQKRQALFKLDNEDGFEEEEEEEEEMTDESEEDGE 647
K EK++V++ +E + + + EE Q + + + + ++ EEE +EEE +E E GE
Sbjct: 439 KSEEKIKVVEKSEKETVIVEEQTEETQVTEEVTEEEEKEAKEEEGKEEEGGEEEEAEGGE 498
Query: 648 EKVEKEEKEEELEEEEEKEEEEEEEGNQETAEFLLSSEEIETKDEKEMDKENNDGSSEIG 707
E+ + EE E+E + +EE EE ++ E + ++ + E
Sbjct: 499 EETKSPPAEEAASPEKEAKSPVKEEAKSPAEAKSPEKEEAKSPAEVKSPEKAKSPAKEEA 558
Query: 708 KAVGFLSVPKSLSSDSTLLLFKDSSSKMGYFPTEEKSETDENSGKQPSK 756
K+ P+ + S + +K P +E++++ + K P K
Sbjct: 559 KSPPEAKSPEKEEAKSPAEVKSPEKAKS---PAKEEAKSPAEA-KSPEK 603
>gi|50897852 coiled-coil domain containing 88A isoform 2 [Homo
sapiens]
Length = 1843
Score = 66.6 bits (161), Expect = 1e-10
Identities = 145/706 (20%), Positives = 290/706 (41%), Gaps = 83/706 (11%)
Query: 46 SDEEIFVSKKLKNRKVLQDSDSETEDTNASPEKTTYDSAEEENKENLYAGKNTKIKRIYK 105
S+ I +S++ L + S + SP +S + + E A KI+R+ +
Sbjct: 208 SETIIELSEERDGLHFLPHASSSAQSPCGSPGMKRTESRQHLSVE--LADAKAKIRRLRQ 265
Query: 106 TVADSDESYMEKSLYQENLEAQVKPCLELSLQSGNSTDFTTDRKSSKKHIHDKEGTAGKA 165
+ + E ++ E +E ++K LQ N + +D +S++ + + + KA
Sbjct: 266 ELEEKTEQLLDCKQELEQMEIELK-----RLQQENM-NLLSDARSARMYRDELDALREKA 319
Query: 166 KVKSKRRLEKEERKMEKIRQLKKKETKNQEDDVEQPFNDSGCLLVDKDLFETGLE----- 220
R++K E ++ + ++ + + + + VE+ D+ LL K + E LE
Sbjct: 320 V-----RVDKLESEVSRYKE-RLHDIEFYKARVEELKEDNQVLLETKTMLEDQLEGTRAR 373
Query: 221 -------DENNSPLEDE-ESLESIRAAVKNKVKKHKKKEPSLESGV-HSFEEGSELSKGT 271
++ N L+ + +E R + K+++ ++ +LE S +E L
Sbjct: 374 SDKLHELEKENLQLKAKLHDMEMERDMDRKKIEELMEENMTLEMAQKQSMDESLHLGWEL 433
Query: 272 TRKERKAARLSKEALKQLHSETQRLIRESALNLPYHMPE-NKTIHDFFKRKPRPTCHGNA 330
+ R + LS+ K L E L L L KT+ + R + GNA
Sbjct: 434 EQISR-TSELSEAPQKSLGHEVNELTSSRLLKLEMENQSLTKTVEEL--RTTVDSVEGNA 490
Query: 331 MALLKSSKYQSSHHK--EIIDTANTTEMNSDHHSKGS-----------EQTTGAENEVET 377
+LK K K EI++ E S + + E+T E
Sbjct: 491 SKILKMEKENQRLSKKVEILENEIVQEKQSLQNCQNLSKDLMKEKAQLEKTIETLRENSE 550
Query: 378 NALPVVSKETQIITGSDESCRKDLVKNEELEIQEKQKQS-----DIRPSPGDSSVLQQES 432
+ ++ +E + + + S R+ + E +++ +K++ I+ + S ++ E
Sbjct: 551 RQIKILEQENEHLNQTVSSLRQRSQISAEARVKDIEKENKILHESIKETSSKLSKIEFEK 610
Query: 433 NFLGN---NHSEECQVGGLVAFEPHALEGEGP------QNPEETDEKVEEPEQQNKSSAV 483
+ ++ E+ + + E H LE E N + T EK+E EQ+N S +
Sbjct: 611 RQIKKELEHYKEKGERAEELENELHHLEKENELLQKKITNLKITCEKIEALEQEN--SEL 668
Query: 484 GPPEKVRRFTLDRLKQLGVDVSI--KPRLGADEDSFVILEPETNRELEALKQRFWKHANP 541
+ + TLD K L + K DE++ E R +E+LK K A
Sbjct: 669 ERENRKLKKTLDSFKNLTFQLESLEKENSQLDEENL-----ELRRNVESLKCASMKMAQ- 722
Query: 542 AAKPRAGQTVNVNVIVKDMGTDGKEELKADVVPVTLAPKKLDGASHTKPGEKLQVLKAKL 601
+ + K++ ++ KE+LK + + + KK + + G L + +L
Sbjct: 723 -----------LQLENKELESE-KEQLKKGLELLKASFKKTERLEVSYQG--LDIENQRL 768
Query: 602 QEAMKLRRFEERQKRQALFKLDNEDGFEEEEEEEEEMTDESEEDGEEKVEKEEKEEELEE 661
Q+ ++ + +Q L L+ E+ ++ EE +++ + E E++ + E+E E
Sbjct: 769 QKTLENSNKKIQQLESELQDLEMENQTLQKNLEELKISSKRLEQLEKENKSLEQETSQLE 828
Query: 662 EEEKEEEEEEEGNQETAEFLLSSEEIETKDEKEMDKENNDGSSEIG 707
+++K+ E+E + ++ AE ++ E ++KEN S EIG
Sbjct: 829 KDKKQLEKENKRLRQQAEIKDTTLEENNVKIGNLEKENKTLSKEIG 874
Score = 54.3 bits (129), Expect = 8e-07
Identities = 202/1017 (19%), Positives = 393/1017 (38%), Gaps = 121/1017 (11%)
Query: 12 EINDPNVISQEEADSPSDSGQGSYETIGPLSEGDSDEEIFVSKKLKNRKVLQDSDSETED 71
E+ + N + E D +G+ L E + E + + KL + ++ +D D + +
Sbjct: 348 ELKEDNQVLLETKTMLEDQLEGTRARSDKLHELEK-ENLQLKAKLHDMEMERDMDRKKIE 406
Query: 72 TNASPEKTTYDSAEEENKENLYAGKNTKIKRIYKTVADSDESYMEKSLYQENLEAQVKPC 131
T + ++ E+L+ G ++++I +T S+ +KSL E E
Sbjct: 407 ELMEENMTLEMAQKQSMDESLHLG--WELEQISRTSELSEAP--QKSLGHEVNELTSSRL 462
Query: 132 LELSLQSGNSTDFTTDRKSSKKHIHDKEGTAGKAKVKSKRRLEKEERKMEKIRQLKKKET 191
L+L +++ + T + +++ + EG A K ++EKE +++ K ++ + E
Sbjct: 463 LKLEMENQSLTKTVEELRTT---VDSVEGNASKIL-----KMEKENQRLSKKVEILENEI 514
Query: 192 KNQEDDVEQPFNDSGCLLVDKDLFETGLEDENNSPLEDEESLESIRAAVKNKVKK-HKKK 250
++ ++ N S L+ +K E +E + + LE + V ++
Sbjct: 515 VQEKQSLQNCQNLSKDLMKEKAQLEKTIETLRENSERQIKILEQENEHLNQTVSSLRQRS 574
Query: 251 EPSLESGVHSFEEGSELS----KGTTRKERKAARLSKEALKQLHSETQRLIRESALNLPY 306
+ S E+ V E+ +++ K T+ K K ++ K+L ++ R L
Sbjct: 575 QISAEARVKDIEKENKILHESIKETSSKLSKIEFEKRQIKKELEHYKEKGERAEELENEL 634
Query: 307 HMPENKTIHDFFKRKP---RPTCHGNAMALLKSSKYQSSHHK--EIIDTANTTEMNSDHH 361
H E + ++ ++K + TC ++S+ + + K + +D+ +
Sbjct: 635 HHLEKE--NELLQKKITNLKITCEKIEALEQENSELERENRKLKKTLDSFKNLTFQLESL 692
Query: 362 SKGSEQTTGAENEVETNA-----LPVVSKETQIITGSDESCRKDLVKNEELEIQEKQKQS 416
K + Q E+ N + + Q+ ES ++ L K EL +K
Sbjct: 693 EKENSQLDEENLELRRNVESLKCASMKMAQLQLENKELESEKEQLKKGLELLKASFKKTE 752
Query: 417 DIRPSPGDSSVLQQESNFLGNNHSEECQVGGLVAFEPHALEGEGP---QNPEE---TDEK 470
+ S + Q N +++ Q + E LE E +N EE + ++
Sbjct: 753 RLEVSYQGLDIENQRLQKTLENSNKKIQQ---LESELQDLEMENQTLQKNLEELKISSKR 809
Query: 471 VEEPEQQNKS--SAVGPPEKVRRFTLDRLKQLGVDVSIKP--------RLGADEDSFVIL 520
+E+ E++NKS EK ++ K+L IK ++G E L
Sbjct: 810 LEQLEKENKSLEQETSQLEKDKKQLEKENKRLRQQAEIKDTTLEENNVKIGNLEKENKTL 869
Query: 521 EPETN---------RELEALKQRFWKHANPAAKPRAG---QTVNVNVIVKDMGTDGKEEL 568
E +ELE + K A K V+ + + M D E+L
Sbjct: 870 SKEIGIYKESCVRLKELEKENKELVKRATIDIKTLVTLREDLVSEKLKTQQMNND-LEKL 928
Query: 569 KADVVPVTLAPKKLDGASHTKPGEKLQVLKAKLQEAMKL-------------RRFEE--- 612
++ + L ++L + + ++L++KL+ +K R EE
Sbjct: 929 THELEKIGLNKERLLHDEQSTDDSRYKLLESKLESTLKKSLEIKEEKIAALEARLEESTN 988
Query: 613 --RQKRQALFKL-DNEDGFEEEEEEEEEMTDESEEDGEE-KVEKEEKEEELEEEEEKEEE 668
+Q RQ L + N + ++ ++EE + GE+ K E+E +E E + K+
Sbjct: 989 YNQQLRQELKTVKKNYEALKQRQDEERMVQSSPPISGEDNKWERESQETTRELLKVKDRL 1048
Query: 669 EEEEGNQETAEFLLSSEEIETKDE-KEMDKENNDGSSEIGKAVGFLSVPKSLSSDSTLLL 727
E E N T L +E+ K + K+++ +NN+ ++I + SL +T L
Sbjct: 1049 IEVERNNAT----LQAEKQALKTQLKQLETQNNNLQAQI---LALQRQTVSLQEQNTTLQ 1101
Query: 728 FKDSSSKMGYFPTEEKSETDENSGK----QPSKLDEDDSCSLLTKESSHNSSFELIGSTI 783
+++ ++ +S + N Q S L+ ++ + +E + LI
Sbjct: 1102 TQNAKLQVENSTLNSQSTSLMNQNAQLLIQQSSLENENESVIKEREDLKSLYDSLIKDHE 1161
Query: 784 PSYQPCNRQTGRGTSFFPTAGGFRSPSPGL-----FRASLVSSASKSSGKLS--EPSLPI 836
RQ S G +S L + K G+L E L +
Sbjct: 1162 KLELLHERQASEYESLISKHGTLKSAHKNLEVEHRDLEDRYNQLLKQKGQLEDLEKMLKV 1221
Query: 837 EDSQDLYNASPEPKTLFLGAGDF-QFCLEDD----TQSQLLDADGFLNVRNHRNQYQALK 891
E + L E K A ++ + C E+D T SQLL L +H+N LK
Sbjct: 1222 EQEKMLL----ENKNHETVAAEYKKLCGENDRLNHTYSQLLKETEVLQT-DHKN----LK 1272
Query: 892 PRLPLASMDENAMDANMDEL------LDLCTGKFTSQAEKHLPRKSDKKENMEELLN 942
L + +++ ++A +L LD+ + K +Q E K + +E LL+
Sbjct: 1273 SLLNNSKLEQTRLEAEFSKLKEQYQQLDITSTKLNNQCELLSQLKGNLEEENRHLLD 1329
>gi|208022632 coiled-coil domain containing 88A isoform 1 [Homo
sapiens]
Length = 1870
Score = 66.6 bits (161), Expect = 1e-10
Identities = 145/706 (20%), Positives = 290/706 (41%), Gaps = 83/706 (11%)
Query: 46 SDEEIFVSKKLKNRKVLQDSDSETEDTNASPEKTTYDSAEEENKENLYAGKNTKIKRIYK 105
S+ I +S++ L + S + SP +S + + E A KI+R+ +
Sbjct: 208 SETIIELSEERDGLHFLPHASSSAQSPCGSPGMKRTESRQHLSVE--LADAKAKIRRLRQ 265
Query: 106 TVADSDESYMEKSLYQENLEAQVKPCLELSLQSGNSTDFTTDRKSSKKHIHDKEGTAGKA 165
+ + E ++ E +E ++K LQ N + +D +S++ + + + KA
Sbjct: 266 ELEEKTEQLLDCKQELEQMEIELK-----RLQQENM-NLLSDARSARMYRDELDALREKA 319
Query: 166 KVKSKRRLEKEERKMEKIRQLKKKETKNQEDDVEQPFNDSGCLLVDKDLFETGLE----- 220
R++K E ++ + ++ + + + + VE+ D+ LL K + E LE
Sbjct: 320 V-----RVDKLESEVSRYKE-RLHDIEFYKARVEELKEDNQVLLETKTMLEDQLEGTRAR 373
Query: 221 -------DENNSPLEDE-ESLESIRAAVKNKVKKHKKKEPSLESGV-HSFEEGSELSKGT 271
++ N L+ + +E R + K+++ ++ +LE S +E L
Sbjct: 374 SDKLHELEKENLQLKAKLHDMEMERDMDRKKIEELMEENMTLEMAQKQSMDESLHLGWEL 433
Query: 272 TRKERKAARLSKEALKQLHSETQRLIRESALNLPYHMPE-NKTIHDFFKRKPRPTCHGNA 330
+ R + LS+ K L E L L L KT+ + R + GNA
Sbjct: 434 EQISR-TSELSEAPQKSLGHEVNELTSSRLLKLEMENQSLTKTVEEL--RTTVDSVEGNA 490
Query: 331 MALLKSSKYQSSHHK--EIIDTANTTEMNSDHHSKGS-----------EQTTGAENEVET 377
+LK K K EI++ E S + + E+T E
Sbjct: 491 SKILKMEKENQRLSKKVEILENEIVQEKQSLQNCQNLSKDLMKEKAQLEKTIETLRENSE 550
Query: 378 NALPVVSKETQIITGSDESCRKDLVKNEELEIQEKQKQS-----DIRPSPGDSSVLQQES 432
+ ++ +E + + + S R+ + E +++ +K++ I+ + S ++ E
Sbjct: 551 RQIKILEQENEHLNQTVSSLRQRSQISAEARVKDIEKENKILHESIKETSSKLSKIEFEK 610
Query: 433 NFLGN---NHSEECQVGGLVAFEPHALEGEGP------QNPEETDEKVEEPEQQNKSSAV 483
+ ++ E+ + + E H LE E N + T EK+E EQ+N S +
Sbjct: 611 RQIKKELEHYKEKGERAEELENELHHLEKENELLQKKITNLKITCEKIEALEQEN--SEL 668
Query: 484 GPPEKVRRFTLDRLKQLGVDVSI--KPRLGADEDSFVILEPETNRELEALKQRFWKHANP 541
+ + TLD K L + K DE++ E R +E+LK K A
Sbjct: 669 ERENRKLKKTLDSFKNLTFQLESLEKENSQLDEENL-----ELRRNVESLKCASMKMAQ- 722
Query: 542 AAKPRAGQTVNVNVIVKDMGTDGKEELKADVVPVTLAPKKLDGASHTKPGEKLQVLKAKL 601
+ + K++ ++ KE+LK + + + KK + + G L + +L
Sbjct: 723 -----------LQLENKELESE-KEQLKKGLELLKASFKKTERLEVSYQG--LDIENQRL 768
Query: 602 QEAMKLRRFEERQKRQALFKLDNEDGFEEEEEEEEEMTDESEEDGEEKVEKEEKEEELEE 661
Q+ ++ + +Q L L+ E+ ++ EE +++ + E E++ + E+E E
Sbjct: 769 QKTLENSNKKIQQLESELQDLEMENQTLQKNLEELKISSKRLEQLEKENKSLEQETSQLE 828
Query: 662 EEEKEEEEEEEGNQETAEFLLSSEEIETKDEKEMDKENNDGSSEIG 707
+++K+ E+E + ++ AE ++ E ++KEN S EIG
Sbjct: 829 KDKKQLEKENKRLRQQAEIKDTTLEENNVKIGNLEKENKTLSKEIG 874
Score = 50.8 bits (120), Expect = 9e-06
Identities = 202/1017 (19%), Positives = 394/1017 (38%), Gaps = 122/1017 (11%)
Query: 12 EINDPNVISQEEADSPSDSGQGSYETIGPLSEGDSDEEIFVSKKLKNRKVLQDSDSETED 71
E+ + N + E D +G+ L E + E + + KL + ++ +D D + +
Sbjct: 348 ELKEDNQVLLETKTMLEDQLEGTRARSDKLHELEK-ENLQLKAKLHDMEMERDMDRKKIE 406
Query: 72 TNASPEKTTYDSAEEENKENLYAGKNTKIKRIYKTVADSDESYMEKSLYQENLEAQVKPC 131
T + ++ E+L+ G ++++I +T S+ +KSL E E
Sbjct: 407 ELMEENMTLEMAQKQSMDESLHLG--WELEQISRTSELSEAP--QKSLGHEVNELTSSRL 462
Query: 132 LELSLQSGNSTDFTTDRKSSKKHIHDKEGTAGKAKVKSKRRLEKEERKMEKIRQLKKKET 191
L+L +++ + T + +++ + EG A K ++EKE +++ K ++ + E
Sbjct: 463 LKLEMENQSLTKTVEELRTT---VDSVEGNASKIL-----KMEKENQRLSKKVEILENEI 514
Query: 192 KNQEDDVEQPFNDSGCLLVDKDLFETGLEDENNSPLEDEESLESIRAAVKNKVKK-HKKK 250
++ ++ N S L+ +K E +E + + LE + V ++
Sbjct: 515 VQEKQSLQNCQNLSKDLMKEKAQLEKTIETLRENSERQIKILEQENEHLNQTVSSLRQRS 574
Query: 251 EPSLESGVHSFEEGSELS----KGTTRKERKAARLSKEALKQLHSETQRLIRESALNLPY 306
+ S E+ V E+ +++ K T+ K K ++ K+L ++ R L
Sbjct: 575 QISAEARVKDIEKENKILHESIKETSSKLSKIEFEKRQIKKELEHYKEKGERAEELENEL 634
Query: 307 HMPENKTIHDFFKRKP---RPTCHGNAMALLKSSKYQSSHHK--EIIDTANTTEMNSDHH 361
H E + ++ ++K + TC ++S+ + + K + +D+ +
Sbjct: 635 HHLEKE--NELLQKKITNLKITCEKIEALEQENSELERENRKLKKTLDSFKNLTFQLESL 692
Query: 362 SKGSEQTTGAENEVETNA-----LPVVSKETQIITGSDESCRKDLVKNEELEIQEKQKQS 416
K + Q E+ N + + Q+ ES ++ L K EL +K
Sbjct: 693 EKENSQLDEENLELRRNVESLKCASMKMAQLQLENKELESEKEQLKKGLELLKASFKKTE 752
Query: 417 DIRPSPGDSSVLQQESNFLGNNHSEECQVGGLVAFEPHALEGEGP---QNPEE---TDEK 470
+ S + Q N +++ Q + E LE E +N EE + ++
Sbjct: 753 RLEVSYQGLDIENQRLQKTLENSNKKIQQ---LESELQDLEMENQTLQKNLEELKISSKR 809
Query: 471 VEEPEQQNKS--SAVGPPEKVRRFTLDRLKQLGVDVSIKP--------RLGADEDSFVIL 520
+E+ E++NKS EK ++ K+L IK ++G E L
Sbjct: 810 LEQLEKENKSLEQETSQLEKDKKQLEKENKRLRQQAEIKDTTLEENNVKIGNLEKENKTL 869
Query: 521 EPETN---------RELEALKQRFWKHANPAAKPRAG---QTVNVNVIVKDMGTDGKEEL 568
E +ELE + K A K V+ + + M D E+L
Sbjct: 870 SKEIGIYKESCVRLKELEKENKELVKRATIDIKTLVTLREDLVSEKLKTQQMNND-LEKL 928
Query: 569 KADVVPVTLAPKKLDGASHTKPGEKLQVLKAKLQEAMKL-------------RRFEE--- 612
++ + L ++L + ++ ++L++KL+ +K R EE
Sbjct: 929 THELEKIGLNKERLLHDEQSTD-DRYKLLESKLESTLKKSLEIKEEKIAALEARLEESTN 987
Query: 613 --RQKRQALFKL-DNEDGFEEEEEEEEEMTDESEEDGEE-KVEKEEKEEELEEEEEKEEE 668
+Q RQ L + N + ++ ++EE + GE+ K E+E +E E + K+
Sbjct: 988 YNQQLRQELKTVKKNYEALKQRQDEERMVQSSPPISGEDNKWERESQETTRELLKVKDRL 1047
Query: 669 EEEEGNQETAEFLLSSEEIETKDE-KEMDKENNDGSSEIGKAVGFLSVPKSLSSDSTLLL 727
E E N T L +E+ K + K+++ +NN+ ++I + SL +T L
Sbjct: 1048 IEVERNNAT----LQAEKQALKTQLKQLETQNNNLQAQI---LALQRQTVSLQEQNTTLQ 1100
Query: 728 FKDSSSKMGYFPTEEKSETDENSGK----QPSKLDEDDSCSLLTKESSHNSSFELIGSTI 783
+++ ++ +S + N Q S L+ ++ + +E + LI
Sbjct: 1101 TQNAKLQVENSTLNSQSTSLMNQNAQLLIQQSSLENENESVIKEREDLKSLYDSLIKDHE 1160
Query: 784 PSYQPCNRQTGRGTSFFPTAGGFRSPSPGL-----FRASLVSSASKSSGKLS--EPSLPI 836
RQ S G +S L + K G+L E L +
Sbjct: 1161 KLELLHERQASEYESLISKHGTLKSAHKNLEVEHRDLEDRYNQLLKQKGQLEDLEKMLKV 1220
Query: 837 EDSQDLYNASPEPKTLFLGAGDF-QFCLEDD----TQSQLLDADGFLNVRNHRNQYQALK 891
E + L E K A ++ + C E+D T SQLL L +H+N LK
Sbjct: 1221 EQEKMLL----ENKNHETVAAEYKKLCGENDRLNHTYSQLLKETEVLQT-DHKN----LK 1271
Query: 892 PRLPLASMDENAMDANMDEL------LDLCTGKFTSQAEKHLPRKSDKKENMEELLN 942
L + +++ ++A +L LD+ + K +Q E K + +E LL+
Sbjct: 1272 SLLNNSKLEQTRLEAEFSKLKEQYQQLDITSTKLNNQCELLSQLKGNLEEENRHLLD 1328
>gi|72534750 splicing factor YT521-B isoform 1 [Homo sapiens]
Length = 727
Score = 66.2 bits (160), Expect = 2e-10
Identities = 48/143 (33%), Positives = 68/143 (47%), Gaps = 28/143 (19%)
Query: 623 DNEDGFEEEEEEEEEMTDESEEDGEEKVEKEEKEEELEEEEEKEEEEEEEGNQETAEFLL 682
+ E+G EE+ EE+EE+ +++EED E + EE+EEE EEEEE+EEEEEEE Q
Sbjct: 200 NEEEGVEEDVEEDEEVEEDAEEDEEVDEDGEEEEEEEEEEEEEEEEEEEEYEQ------- 252
Query: 683 SSEEIETKDEKEMDKENNDGSSEIGKAVGFLSVPKSLSSDSTLLLFKDSSSKMGY---FP 739
DE++ +E ND + ++ S S + F D S + G
Sbjct: 253 --------DERDQKEEGNDYDTR----------SEASDSGSESVSFTDGSVRSGSGTDGS 294
Query: 740 TEEKSETDENSGKQPSKLDEDDS 762
E+K E G P D S
Sbjct: 295 DEKKKERKRARGISPIVFDRSGS 317
Score = 59.7 bits (143), Expect = 2e-08
Identities = 51/165 (30%), Positives = 81/165 (49%), Gaps = 18/165 (10%)
Query: 622 LDNEDGFEEEEEEEEEMTDESEEDGEEKVEKEEKEEELEEE-EEKEEEEEEEGNQETAEF 680
++ ++ EE+ EE+EE+ ++ EE+ EE+ E+EE+EEE EEE E+ E +++EEGN
Sbjct: 209 VEEDEEVEEDAEEDEEVDEDGEEEEEEEEEEEEEEEEEEEEYEQDERDQKEEGNDYDTRS 268
Query: 681 LLS---SEEIETKDEKEMDKENNDGSSEIGKAVGFLSVPKSLSSDSTLLLFKD-SSSKMG 736
S SE + D DGS E K K S ++ + SS+
Sbjct: 269 EASDSGSESVSFTDGSVRSGSGTDGSDEKKKE------RKRARGISPIVFDRSGSSASES 322
Query: 737 YFPTEEKSETDENSGK-----QPSKLDE--DDSCSLLTKESSHNS 774
Y +E+K E +S + Q SKL D+ L K ++H +
Sbjct: 323 YAGSEKKHEKLSSSVRAVRKDQTSKLKYVLQDARFFLIKSNNHEN 367
Score = 40.0 bits (92), Expect = 0.015
Identities = 39/197 (19%), Positives = 85/197 (43%), Gaps = 16/197 (8%)
Query: 5 VGSEVHLEINDPNVISQEEADSP---SDSGQGSYETIGPLSEGDSDEEIFVSKKLKNRKV 61
+G EV + + S+EE +S SD GS + +EE V + ++ +
Sbjct: 155 IGLEVDRRASRSSQSSKEEVNSEEYGSDHETGSSGSSDEQGNNTENEEEGVEEDVEEDEE 214
Query: 62 LQDSDSETEDTNASPEKTTYDSAEEENKENLYAGKNTKIKRIYKTVADSDESYMEKSLYQ 121
+++ E E+ + E+ + EEE +E + + +R K + ++ E S
Sbjct: 215 VEEDAEEDEEVDEDGEEEEEEEEEEEEEEEEEEEEYEQDERDQKEEGNDYDTRSEAS--- 271
Query: 122 ENLEAQVKPCLELSLQSGNSTDFTTDRKSSKKH-------IHDKEGTAGKAKVKSKRRLE 174
+ ++ + S++SG+ TD + ++K +K + D+ G++ +
Sbjct: 272 -DSGSESVSFTDGSVRSGSGTDGSDEKKKERKRARGISPIVFDRSGSSASESYAGSEK-- 328
Query: 175 KEERKMEKIRQLKKKET 191
K E+ +R ++K +T
Sbjct: 329 KHEKLSSSVRAVRKDQT 345
Score = 38.5 bits (88), Expect = 0.044
Identities = 52/236 (22%), Positives = 91/236 (38%), Gaps = 46/236 (19%)
Query: 226 PLEDEESLESIRAAVKNKVKKHKKKEPSLES--------GVHSFEEGSE-LSKGTTRKER 276
P +D+E KN+ K K+K +ES VHS + S+ LS + +R
Sbjct: 24 PEQDDELYNPESEQDKNEKKGSKRKSDRMESTDTKRQKPSVHSRQLVSKPLSSSVSNNKR 83
Query: 277 KAARLSKEALKQLHSETQRLIRESALNL-------------PYHMPENKTI---HDFFKR 320
+ K A + + E QR R L+ PY KT D +R
Sbjct: 84 IVSTKGKSATEYKNEEYQRSERNKRLDADRKIRLSSSASREPYKNQPEKTCVRKRDPERR 143
Query: 321 KPRPTCHGNAMALLK-----------------SSKYQSSHHKEIIDTANTTEMNSDHHSK 363
PT G+ L+ S +Y S H +++ N+++ +
Sbjct: 144 AKSPTPDGSERIGLEVDRRASRSSQSSKEEVNSEEYGSDHETGSSGSSDEQGNNTENEEE 203
Query: 364 GSEQTTGAENEVETNALPVVSKETQIITGSDESCRKDLVKNEELEIQEKQKQSDIR 419
G E+ + EVE +A ++ ++ +E ++ + EE E +E++ + D R
Sbjct: 204 GVEEDVEEDEEVEEDA----EEDEEVDEDGEEEEEEEEEEEEEEEEEEEEYEQDER 255
Score = 38.5 bits (88), Expect = 0.044
Identities = 21/83 (25%), Positives = 44/83 (53%), Gaps = 2/83 (2%)
Query: 1006 NDNEFDSDEDEHSDSGNDLALEDHEDDDE--EELLKRSEKLKRQMRLRKYLEDEAEVSGS 1063
N E+ SD + S +D + E+++E EE ++ E+++ + ++++ E
Sbjct: 175 NSEEYGSDHETGSSGSSDEQGNNTENEEEGVEEDVEEDEEVEEDAEEDEEVDEDGEEEEE 234
Query: 1064 DVGSEDEYDGEEIDEYEEDVIDE 1086
+ E+E + EE +EYE+D D+
Sbjct: 235 EEEEEEEEEEEEEEEYEQDERDQ 257
Score = 37.0 bits (84), Expect = 0.13
Identities = 40/153 (26%), Positives = 65/153 (42%), Gaps = 9/153 (5%)
Query: 919 FTSQAEKHLPRKSDKKENMEELLNLCSGKFTSQ-DASTPASSELNKQEKESSMGDPMEEA 977
+ +Q EK RK D + + S + + D SS+ +K+E S E
Sbjct: 126 YKNQPEKTCVRKRDPERRAKSPTPDGSERIGLEVDRRASRSSQSSKEEVNSEEYGSDHET 185
Query: 978 LALCSGSFP-----TDKEEEDEEEEFGDFRLVSNDNEFDSDEDEHSDSGNDLALEDHEDD 1032
+ SGS T+ EEE EE+ + V D E D + DE + + E+ E++
Sbjct: 186 GS--SGSSDEQGNNTENEEEGVEEDVEEDEEVEEDAEEDEEVDEDGEEEEEEEEEEEEEE 243
Query: 1033 DEEELLKRSEKLKRQMRLRKY-LEDEAEVSGSD 1064
+EEE ++ ++ Y EA SGS+
Sbjct: 244 EEEEEEYEQDERDQKEEGNDYDTRSEASDSGSE 276
Score = 35.8 bits (81), Expect = 0.28
Identities = 36/157 (22%), Positives = 67/157 (42%), Gaps = 16/157 (10%)
Query: 132 LELSLQSGNSTDFTTDRKSSKKHIHDKEGTAGKAKVKSKRRLEKEERKMEKIRQLKKKET 191
LE+ ++ S+ + + +S+++ D E + + + E EE +E E
Sbjct: 157 LEVDRRASRSSQSSKEEVNSEEYGSDHETGSSGSSDEQGNNTENEEEGVE--------ED 208
Query: 192 KNQEDDVEQPFNDSGCLLVDKDLFETGLEDENNSPLEDEESLESIRAAVKNKVKKHKKKE 251
++++VE+ + + D + E E+E E+EE E K + + +
Sbjct: 209 VEEDEEVEEDAEEDEEVDEDGEEEEEEEEEEEEEEEEEEEEYEQDERDQKEEGNDYDTRS 268
Query: 252 PSLESGVH--SFEEGSELSKGTT------RKERKAAR 280
+ +SG SF +GS S T +KERK AR
Sbjct: 269 EASDSGSESVSFTDGSVRSGSGTDGSDEKKKERKRAR 305
>gi|221219020 NYD-SP11 protein [Homo sapiens]
Length = 2873
Score = 65.1 bits (157), Expect = 4e-10
Identities = 55/177 (31%), Positives = 88/177 (49%), Gaps = 16/177 (9%)
Query: 555 VIVKDMGTDGKEELKADVVPVTLAP--KKLDGASHTKPGEKL--QVLKAKLQE--AMKLR 608
VI+ D G EE +V+P K+ + KP EK QV + + +E + ++
Sbjct: 2174 VILDDEEEGGIEE--EEVIPFLKRRWRKRKEAKRGDKPKEKFSSQVDEVESEEHFSEEME 2231
Query: 609 RFEERQKRQALFKLDNEDGFEEEEEEEEEMTDESEEDGEEKVEKEEKEEELEEEE----- 663
+ ++Q + E+ EEEEE EEE E EE+ +E+ E EEK+ E EEEE
Sbjct: 2232 SLLDELEKQESLSSEEEEEREEEEEREEEEVREEEEERKEEEEGEEKQVEKEEEEKKKKK 2291
Query: 664 ---EKEEEEEEEGNQETAEFLLSSEEIETKDEKEMDKENNDGSSEIGKAVGFLSVPK 717
+KEE +E+E E E ++S EE E+ ++E ++E+ E+ + L K
Sbjct: 2292 KEKKKEEVQEKEEVFEEKEEIMSEEETESLSDEEEEEESCSLEEEVDREKEILKKEK 2348
Score = 61.6 bits (148), Expect = 5e-09
Identities = 154/733 (21%), Positives = 288/733 (39%), Gaps = 123/733 (16%)
Query: 84 AEEENKENLYAGKNTKIKRIYKTVADSDESYMEKSLYQENLEAQVKPCLELSLQSGNSTD 143
A EE K GK ++K I +A E ++ ++NL+ Q K EL+ Q +
Sbjct: 1673 AREEEKLAKKGGKLAEVKNI---LAQKVEELPQR---EQNLDWQEK---ELA-QELEELE 1722
Query: 144 FTTDRKSSKKHIHDKEGTAGKAKVKSKRRLEKEERKMEKIRQLKKKETKNQEDDVEQPFN 203
+ + S K+ ++E GK + K+ E+EE + +L ++ETK +++
Sbjct: 1723 WDMEELSWKEEELNQE--EGKLVEEKKKLAEEEEALAWQREKLSEEETKLAQEEE----- 1775
Query: 204 DSGCLLVDKDLFETGLEDENNSPLEDEESLESIRAAVKNKVKKHKKKEPSLESGVHSFEE 263
LL+ + E + + P E+E ++ K+K +K+E ++S EE
Sbjct: 1776 ----LLIQEK--EKLAQHKEKMPEEEERLGRKREQLIEKKMKLAQKRE----RWINSMEE 1825
Query: 264 GSE-----LSKGTTRKERKAARLSKEALKQ------------LHSETQRLIRESAL---N 303
++ K +E+K KE L Q HS+ Q + ++ L N
Sbjct: 1826 LTKNKMILYQKKNLAQEKKNLAQEKEKLAQRKENLLYNKERLTHSKKQLVQVKNKLGMFN 1885
Query: 304 LPYHMPENKTIHD---FFKRKPRPTCHGNAMALLKSS--KYQSSHHKEIIDTANTTEM-N 357
E K + K+K + + ++ S K Q +E + A M
Sbjct: 1886 KILAQVEEKLTQEKETVIKKKEKLAETEKKLVQVEDSLAKKQEKLAQEKMKLALEKAMVQ 1945
Query: 358 SDHHSKGSEQTTGAENEVETNALPVVSKETQIITGSDESCRKDLVKNEELEIQEKQKQSD 417
+G E + + ++ +++ G ++ L K E E ++K +
Sbjct: 1946 GKKRLRGELDIAKEEKALNLEMKRLAEEKMRLVEG-----KETLSKGETPETSRQRKMTQ 2000
Query: 418 I------RPSPGDSSVLQQESNFLGNNHSEECQVGGLVAFEPHALEGEGPQNPEETDEKV 471
+ R + +L E L SE + G L + +G + + K+
Sbjct: 2001 VEQELFERKLSLEEKILLHEDRILAMEESEIAK-GKLEFTRGQRIFVQGQRKLAKASRKL 2059
Query: 472 --------EEPEQQNK--SSAVGPPEKVRRFTLDRLKQLGVDVSI---KPRLGADEDSFV 518
+EP + NK + R+ T + +K + ++ + RL ++
Sbjct: 2060 IKKRESLSKEPAKLNKILKALQKLTRDERKLTQEEIKMTKMKRALFVKERRLSIEQSKLD 2119
Query: 519 ILEPETNRELEALKQRFWKHANPAAKPRAGQTVNVNVIVKDMGTDGKEELKADVVPVTLA 578
I E + + + L + K A K +N ++ T+ + +L V L
Sbjct: 2120 IKEWDFSEKRSELTKDEKKLARKQRKLANKMRRMINK--EEKMTEEESKLARKHSEVILD 2177
Query: 579 PKKLDGASHTKPGEKLQVLKAKLQEAMKLRRFEERQKR--QALFKLDNEDGFEEEEE--- 633
++ G E + LK + ++ + +R ++ +++ + ++++E+ F EE E
Sbjct: 2178 DEEEGGIEEE---EVIPFLKRRWRKRKEAKRGDKPKEKFSSQVDEVESEEHFSEEMESLL 2234
Query: 634 -EEEEMTDESEEDGEEKVEKEEKEEELEEEEEKEEEEEEEGNQETAEFLLSSEEIETKDE 692
E E+ S E+ EE+ E+EE+EEE EEE+E +EEEEG ++ E EE + K +
Sbjct: 2235 DELEKQESLSSEEEEEREEEEEREEEEVREEEEERKEEEEGEEKQVE---KEEEEKKKKK 2291
Query: 693 KEMDKENNDGSSEIGKAVGFLSVPKSLSSDSTLLLFKDSSSKMGYFPTEEKSETDENSGK 752
KE KE E+ F++ M TE S+ +E
Sbjct: 2292 KEKKKEEVQEKEEV---------------------FEEKEEIMSEEETESLSDEEE---- 2326
Query: 753 QPSKLDEDDSCSL 765
E++SCSL
Sbjct: 2327 ------EEESCSL 2333
Score = 52.8 bits (125), Expect = 2e-06
Identities = 135/706 (19%), Positives = 270/706 (38%), Gaps = 83/706 (11%)
Query: 78 KTTYDSAEEENKENLYAGKN-TKIKRIYKTVADSDESYMEKSLYQENLEAQVKPCLELSL 136
K T D E E +A K T +R K ++++ ++ + E + +L+
Sbjct: 1622 KITQDDREMAQAEGKFAQKEETLAQRGEKLSQEAEKLAQKRKKLAKKWEKVAREEEKLAK 1681
Query: 137 QSGNSTDFTTDRKSSKKHIHDKEGTAGKAKVKSKRRLEKEERKMEKIRQLKKKETKNQED 196
+ G + + + +E + + + LE+ E ME++ K+E NQE+
Sbjct: 1682 KGGKLAEVKNILAQKVEELPQREQNLDWQEKELAQELEELEWDMEELSW--KEEELNQEE 1739
Query: 197 DVEQPFNDSGCLLVDKDLF---ETGLEDENNSPLEDEESL---ESIRAAVKNKVKKHKKK 250
G L+ +K E L + E+E L E + K K+ +HK+K
Sbjct: 1740 ---------GKLVEEKKKLAEEEEALAWQREKLSEEETKLAQEEELLIQEKEKLAQHKEK 1790
Query: 251 EPSLESGVHSFEEGSELSKGTTRKERKAARLSKEALKQLHSETQRLIRESALNLPYHMPE 310
P EE L + + K +L+++ + ++S + + L ++ +
Sbjct: 1791 MP---------EEEERLGRKREQLIEKKMKLAQKRERWINSMEELTKNKMILYQKKNLAQ 1841
Query: 311 NKTIHDFFKRKPRPTCHGNAMALLKSSKYQSSHHKEIIDTANTTEMNSDHHSKGSEQTTG 370
K K K LL + + + K+++ N M + ++ E+ T
Sbjct: 1842 EKKNLAQEKEKLAQRKEN----LLYNKERLTHSKKQLVQVKNKLGMFNKILAQVEEKLTQ 1897
Query: 371 AENEVETNALPVVSKETQIITGSDESCRKDLVKNEELEIQEKQKQSDIRPSPGDSSVLQQ 430
+ V + E +++ D L K +E QEK K + + +++Q
Sbjct: 1898 EKETVIKKKEKLAETEKKLVQVEDS-----LAKKQEKLAQEKMKLAL------EKAMVQG 1946
Query: 431 ESNFLGNNHSEECQVGGLVAFEPHALEGEGPQNPEETDEKVEEPEQQNKSSAVGPPEKVR 490
+ G +A E AL E + EE VE E +K PE R
Sbjct: 1947 KKRLRGELD---------IAKEEKALNLEMKRLAEEKMRLVEGKETLSKGET---PETSR 1994
Query: 491 RFTLDRLKQLGVD--VSIKPRLGADEDSFVILEPETNRELEALKQRFWKHANPAAKPRAG 548
+ + +++Q + +S++ ++ ED + +E E+ K F + + +
Sbjct: 1995 QRKMTQVEQELFERKLSLEEKILLHEDRILAMEES---EIAKGKLEFTRGQRIFVQGQRK 2051
Query: 549 QTVNVNVIVKDMGTDGKEELKADVVPVTLAPKKLDGASHTKPGEKLQVLKAKLQEAMKLR 608
++K + KE K + + L D T+ E++++ K K +K R
Sbjct: 2052 LAKASRKLIKKRESLSKEPAKLNKILKALQKLTRDERKLTQ--EEIKMTKMKRALFVKER 2109
Query: 609 RFEERQKRQALFKLDNEDGFEEEEEEEEEMTDESEEDGEEKVEKEEKEEELEEEEEKEEE 668
R Q KLD ++ + E+ E+T + ++ ++ + K + +EEK E
Sbjct: 2110 RLSIEQS-----KLDIKEW--DFSEKRSELTKDEKKLARKQRKLANKMRRMINKEEKMTE 2162
Query: 669 EEEEGNQETAEFLLSSEEIETKDEKEM-------------DKENNDGSSEIGKAVGFLSV 715
EE + ++ +E +L EE +E+E+ K + + V +
Sbjct: 2163 EESKLARKHSEVILDDEEEGGIEEEEVIPFLKRRWRKRKEAKRGDKPKEKFSSQVDEVES 2222
Query: 716 PKSLSSDSTLLLFKDSSSKMGYFPTEEKSETDENSGKQPSKLDEDD 761
+ S + LL D K +EE+ E +E ++ ++ E++
Sbjct: 2223 EEHFSEEMESLL--DELEKQESLSSEEEEEREEEEEREEEEVREEE 2266
Score = 44.7 bits (104), Expect = 6e-04
Identities = 50/251 (19%), Positives = 113/251 (45%), Gaps = 13/251 (5%)
Query: 57 KNRKVLQDSDSETEDTNASPEKTTYDSAEEENKENLYAGKNTKIKRIYKTVADSDESYME 116
K+ +V+ D + E E+ + ++ A + K K + + D ES
Sbjct: 2170 KHSEVILDDEEE----GGIEEEEVIPFLKRRWRKRKEAKRGDKPKEKFSSQVDEVESEEH 2225
Query: 117 KSLYQENLEAQVKPCLELSLQSGNSTDFTTDRKSSKKHIHDKEGTAGKAKVKSKRRLEKE 176
S E+L +++ + SL S + + + ++ + ++E + + ++++EKE
Sbjct: 2226 FSEEMESLLDELEK--QESLSSEEEEEREEEEEREEEEVREEEEERKEEEEGEEKQVEKE 2283
Query: 177 ERKMEKIRQLKKKETKNQEDDVEQPFNDSGCLLVDKDLFETGLEDENNSPLEDEESLESI 236
E + +K ++ KKKE ++++V F + ++ +++ E+E EE ++
Sbjct: 2284 EEEKKKKKKEKKKEEVQEKEEV---FEEKEEIMSEEETESLSDEEEEEESCSLEEEVDRE 2340
Query: 237 RAAVKNKVKKHKKKEPSLESGVHSFEEGSELSKGTTRKERKAARLS--KEALKQLHSETQ 294
+ +K K K+ K +E +S + E + +G + +A RL K LK+L S
Sbjct: 2341 KEILK-KEKQFKLQEQRRKS-LRGRERVLSILRGVPHGKGRAIRLGVLKSPLKKLMSTAL 2398
Query: 295 RLIRESALNLP 305
+ ++ + +P
Sbjct: 2399 EMKEKTPVPVP 2409
Score = 44.3 bits (103), Expect = 8e-04
Identities = 41/132 (31%), Positives = 65/132 (49%), Gaps = 28/132 (21%)
Query: 591 GEKLQVLKAKLQEAMKLRRFEERQ---------KRQALFKLDNEDGFEEE-----EEEEE 636
GEKL + LQE KL+ E +Q ++ +K + E EEE EE+E+
Sbjct: 1500 GEKLSPEEEMLQEDKKLKWEEWKQVWENMLSSKSKEQQYKDEEEVTLEEEVSREGEEKEQ 1559
Query: 637 EMTDESEEDGEE-----------KVEKEEKEEE--LEEEEEKEEEEEEEGNQETAEFLLS 683
++T+E EE + EK+ +EE L +EEEK +EE + QE + +
Sbjct: 1560 QVTEEQRHIQEEHKWARIHRKRARAEKKRAQEERKLAQEEEKLAQEERQLAQEERKLAQA 1619
Query: 684 SEEIETKDEKEM 695
+I T+D++EM
Sbjct: 1620 YVKI-TQDDREM 1630
Score = 44.3 bits (103), Expect = 8e-04
Identities = 125/652 (19%), Positives = 252/652 (38%), Gaps = 72/652 (11%)
Query: 47 DEEIFVSKKLKNRKVLQDSDSETEDTNASPEKTTYDSAEEENKENLYAGKNTKIKRIYKT 106
+EE+ + +K K + + E E E+ E K L + I + +
Sbjct: 1773 EEELLIQEKEKLAQHKEKMPEEEERLGRKREQLI------EKKMKLAQKRERWINSMEEL 1826
Query: 107 VADSDESYMEKSLYQE--NLEAQVKPCLELSLQSGNSTDFTTDRKSSKKHIHDKEGTAGK 164
+ Y +K+L QE NL + + + + + T K + +K G K
Sbjct: 1827 TKNKMILYQKKNLAQEKKNLAQEKEKLAQRKENLLYNKERLTHSKKQLVQVKNKLGMFNK 1886
Query: 165 --AKVKSKRRLEKEE--RKMEKIRQLKKKETKNQED---DVEQPFNDSGCLLVDKDLFET 217
A+V+ K EKE +K EK+ + +KK + ++ E+ + L ++K + +
Sbjct: 1887 ILAQVEEKLTQEKETVIKKKEKLAETEKKLVQVEDSLAKKQEKLAQEKMKLALEKAMVQ- 1945
Query: 218 GLEDENNSPLEDEESLESIRAAVKNKVKKHKKKEPSLESGVHSFEEGSELSKGTTRKERK 277
L E + A+ ++K+ +++ L G + +G T ++RK
Sbjct: 1946 -----GKKRLRGELDIAKEEKALNLEMKRLAEEKMRLVEGKETLSKGETPE---TSRQRK 1997
Query: 278 AARLSKEALKQLHSETQRLIRESALNLPYHMPENKTIHDFFKRKPRPTCHGNAMALLKSS 337
++ +E ++ S ++++ L E F R R G S
Sbjct: 1998 MTQVEQELFERKLSLEEKILLHEDRILAMEESEIAKGKLEFTRGQRIFVQGQRKLAKASR 2057
Query: 338 KYQSSHHKEIIDTANTTEMNSDHHSKGSEQTTGAENEVETNALPVVSKETQIITGSDESC 397
K + A ++ K ++ T E ++ + + + +
Sbjct: 2058 KLIKKRESLSKEPAKLNKI-----LKALQKLTRDERKLTQEEIKMTKMKRALFVKE---- 2108
Query: 398 RKDLVKNEELEIQE---KQKQSDIRPSPGDSSVLQQESNFLGNNHSEECQVGGLVAFEPH 454
R+ ++ +L+I+E +K+S++ D L ++ L N ++ ++ E
Sbjct: 2109 RRLSIEQSKLDIKEWDFSEKRSELTK---DEKKLARKQRKLAN------KMRRMINKEEK 2159
Query: 455 ALEGEGPQNPEETDEKVEEPEQQNKSSAVGPPEKVRRFTLDRLKQLGVDVSIKPRLGADE 514
E E + ++ +++ E+ P RR+ + + G K DE
Sbjct: 2160 MTEEESKLARKHSEVILDDEEEGGIEEEEVIPFLKRRWRKRKEAKRGDKPKEKFSSQVDE 2219
Query: 515 DSFVILEPETNRELEALKQRFWKHANPAAKPRAGQTVNVNVIVKDMGTDGKEELKADVVP 574
V E + E+E+L K + +++ ++ + +EE + + V
Sbjct: 2220 ---VESEEHFSEEMESLLDELEKQESLSSE-------------EEEEREEEEEREEEEVR 2263
Query: 575 VTLAPKKLDGASHTKPGEKLQVLKAKLQEAMKLRRFEERQKRQALFKLDNEDGFEEEEEE 634
+K + + GE+ QV K +E K ++ +E++K + K E+ FEE+EE
Sbjct: 2264 EEEEERKEE-----EEGEEKQVEK---EEEEKKKKKKEKKKEEVQEK---EEVFEEKEEI 2312
Query: 635 EEEMTDESEEDGEEKVEKEEKEEELEEEEEKEEEEEEEGNQETAEFLLSSEE 686
E ES D EE+ E EEE++ E+E ++E++ QE L E
Sbjct: 2313 MSEEETESLSDEEEEEESCSLEEEVDREKEILKKEKQFKLQEQRRKSLRGRE 2364
Score = 43.9 bits (102), Expect = 0.001
Identities = 40/172 (23%), Positives = 79/172 (45%), Gaps = 23/172 (13%)
Query: 958 SSELNKQEKESSMGDPMEEALALCSGSFPTDKEEEDEEEEFGDFRLVSNDNEFDSDEDEH 1017
SS++++ E E + ME L EEE+E EE E + +E+E
Sbjct: 2214 SSQVDEVESEEHFSEEMESLLDELEKQESLSSEEEEEREE-----------EEEREEEEV 2262
Query: 1018 SDSGNDLALEDH------EDDDEEELLKRSEKLKRQMRLRKYLEDEAEVSGSDVGSEDEY 1071
+ + E+ E ++EE+ K+ EK K +++ ++ + +E E ++ SE+E
Sbjct: 2263 REEEEERKEEEEGEEKQVEKEEEEKKKKKKEKKKEEVQEKEEVFEEKE----EIMSEEET 2318
Query: 1072 DGEEIDEYEEDVIDEVLPSDEELQSQIKKIHMKTMLDDDKRQLRLYQERYLA 1123
+ +E EE+ L + + + +I K + L + +R+ +ER L+
Sbjct: 2319 ESLSDEEEEEESCS--LEEEVDREKEILKKEKQFKLQEQRRKSLRGRERVLS 2368
Score = 43.1 bits (100), Expect = 0.002
Identities = 46/195 (23%), Positives = 85/195 (43%), Gaps = 8/195 (4%)
Query: 589 KPGEKLQVLKAKLQEAMKLRRFEERQKRQALFKLDN-EDGFEEEEEEEEEMTDESEEDGE 647
K E +L K++E + + + Q+++ +L+ E EE +EEE+ E + E
Sbjct: 1685 KLAEVKNILAQKVEELPQREQNLDWQEKELAQELEELEWDMEELSWKEEELNQEEGKLVE 1744
Query: 648 EKVEKEEKEEELEEEEEKEEEEEEEGNQETAEFLLSSEEIETKDEKEMDKENNDGSSE-- 705
EK + E+EE L + EK EEE + QE + E++ EK ++E G
Sbjct: 1745 EKKKLAEEEEALAWQREKLSEEETKLAQEEELLIQEKEKLAQHKEKMPEEEERLGRKREQ 1804
Query: 706 -IGKAVGFLSVPKSLSSDSTLLLFKDSSSKMGYFPTEEKSETDENSGKQPSKLDEDDSCS 764
I K + + + L + +KM + + ++ +N ++ KL +
Sbjct: 1805 LIEKKMKLAQKRERWINSMEEL----TKNKMILYQKKNLAQEKKNLAQEKEKLAQRKENL 1860
Query: 765 LLTKESSHNSSFELI 779
L KE +S +L+
Sbjct: 1861 LYNKERLTHSKKQLV 1875
Score = 42.0 bits (97), Expect = 0.004
Identities = 137/663 (20%), Positives = 260/663 (39%), Gaps = 122/663 (18%)
Query: 48 EEIFVSKKLKNRKVLQDSDSETEDTNASPEKTTYDSAEEENKENLYAGKNTKIKRIYKTV 107
+EI K +++ +L+D D + PEK E +E++ G ++ R + +
Sbjct: 1288 QEICPLLKKESKVLLEDLDWDV----VPPEKKPIFIQEGAIREDMIQGVTQEVIRHKEVM 1343
Query: 108 ADSDESYMEKSLYQENLE-AQV---KPCLELSLQSGNSTDFTTDRKSSKKHIHDKEGTAG 163
+E +K+ LE QV K + L+ GN T ++ SKK +E
Sbjct: 1344 PREEEQAQKKARDMLGLEETQVILKKGKKVIFLEPGN---VTMGKEISKK----EEKKTF 1396
Query: 164 KAKVKSKRRLEKEERKMEKIRQLKKKETKNQEDDVEQPFNDSGCLLVDKDLFETGLEDEN 223
+ K R+ ++ERK+ KI++ KE ++ ++VE+
Sbjct: 1397 QKSPKQGRKAVQKERKVGKIKREMTKEERDMSEEVEE----------------------- 1433
Query: 224 NSPLEDEESLESIRAAVKNKVKKHK------KKEPSLESGVHSFEEGSELSKGTTRKERK 277
A ++ KV K + ++ PS + +++E ++ G TRK K
Sbjct: 1434 -------------MATLEEKVVKQEGKLVMIERTPSWQDWKKAWDEWKQV-HGETRKSWK 1479
Query: 278 AARLSKEALKQLHSETQRLIRESALNLPYHMPENKTIHDFFKRKPRPTCHGNAMALLKSS 337
A + +E K+L E ++L ++ L PE + + + K K + SS
Sbjct: 1480 AWK--EEWEKRLLQEEEKL-HQAGEKL---SPEEEMLQEDKKLKWEE--WKQVWENMLSS 1531
Query: 338 KYQSSHHKEIIDTANTTEMNSDHHSKGSEQTTGAENEVETNALPVVSKETQIITGSDESC 397
K + +K+ + E++ + K +Q T + ++ K +I +
Sbjct: 1532 KSKEQQYKDEEEVTLEEEVSREGEEK-EQQVTEEQRHIQEE-----HKWARIHRKRARAE 1585
Query: 398 RKDLVKNEELEIQEKQKQSDIRPSPGDSSVLQQESNFLGNNHSEECQVGGLVAFEPHALE 457
+K + +L +E++ + R + L Q + + E Q G A + L
Sbjct: 1586 KKRAQEERKLAQEEEKLAQEERQLAQEERKLAQAYVKITQDDREMAQAEGKFAQKEETLA 1645
Query: 458 GEGPQNPEETDEKVEEPEQQNKSSAVGPPEKVRRFTLDRLKQLGVDVSIKPRLGADEDSF 517
G E+ ++ E+ Q+ K A EKV R K+ G +K L
Sbjct: 1646 QRG----EKLSQEAEKLAQKRKKLA-KKWEKVAREEEKLAKKGGKLAEVKNILA------ 1694
Query: 518 VILEPETNRELEALKQRFWKHANPAAKPRAGQTVNVNVIVKDMGTDGKEELKADVVPVTL 577
+++E L QR N++ K++ + EEL+ D+ ++
Sbjct: 1695 --------QKVEELPQR---------------EQNLDWQEKELAQE-LEELEWDMEELSW 1730
Query: 578 APKKLDGASHTKPGEKLQVLKAKLQEAMKLRRFEERQKRQALFKLDNEDGFEEEEEEEEE 637
E+L + KL E K EE KL E+ + +EEE
Sbjct: 1731 KE------------EELNQEEGKLVEEKKKLAEEEEALAWQREKLSEEE--TKLAQEEEL 1776
Query: 638 MTDESEEDGEEKVEKEEKEEELEEEEEKEEEEEEEGNQETAEFLLSSEEIETKDEKEMDK 697
+ E E+ + K + E+EE L + E+ E++ + Q+ ++ S EE+ TK++ + +
Sbjct: 1777 LIQEKEKLAQHKEKMPEEEERLGRKREQLIEKKMKLAQKRERWINSMEEL-TKNKMILYQ 1835
Query: 698 ENN 700
+ N
Sbjct: 1836 KKN 1838
Score = 40.8 bits (94), Expect = 0.009
Identities = 58/209 (27%), Positives = 87/209 (41%), Gaps = 27/209 (12%)
Query: 591 GEKLQVLKAKLQEAMKLRRFEERQKRQALFKLDNEDGFEEEEEEEEEMTDESEEDGEEKV 650
GEKL QEA KL QKR+ L K +E+ EEE++ + + E K
Sbjct: 1648 GEKLS------QEAEKLA-----QKRKKLAKK-----WEKVAREEEKLAKKGGKLAEVKN 1691
Query: 651 EKEEKEEELEEEEEKEEEEEEEGNQETAEFLLSSEEIETKDEKEMDKENNDGSSEIGKAV 710
+K EEL + E+ + +E+E QE E EE+ K+E E+++E E K
Sbjct: 1692 ILAQKVEELPQREQNLDWQEKELAQELEELEWDMEELSWKEE-ELNQEEGKLVEEKKKLA 1750
Query: 711 ----GFLSVPKSLSSDSTLL-----LFKDSSSKMGYFPTEEKSETDENSGKQPSKLDEDD 761
+ LS + T L L K+ E+ E +E G++ +L E
Sbjct: 1751 EEEEALAWQREKLSEEETKLAQEEELLIQEKEKLAQH-KEKMPEEEERLGRKREQLIEKK 1809
Query: 762 SCSLLTKESSHNSSFELIGSTIPSYQPCN 790
+E NS EL + + YQ N
Sbjct: 1810 MKLAQKRERWINSMEELTKNKMILYQKKN 1838
Score = 39.7 bits (91), Expect = 0.020
Identities = 45/176 (25%), Positives = 77/176 (43%), Gaps = 16/176 (9%)
Query: 961 LNKQEKESSMGDPMEEALALCSGSFPTDKEEED--EEEEFGDF-----RLVSNDNEFDSD 1013
+NK+EK + E LA D EEE EEEE F R D
Sbjct: 2154 INKEEKMTEE----ESKLARKHSEVILDDEEEGGIEEEEVIPFLKRRWRKRKEAKRGDKP 2209
Query: 1014 EDEHSDSGNDLALEDHEDDDEEELLKRSEKLKRQMRLRKYLEDEAEVSGSDVGSEDEYDG 1073
+++ S +++ E+H ++ E LL ++L++Q L E+E E + E+E
Sbjct: 2210 KEKFSSQVDEVESEEHFSEEMESLL---DELEKQESLSS--EEEEEREEEEEREEEEVRE 2264
Query: 1074 EEIDEYEEDVIDEVLPSDEELQSQIKKIHMKTMLDDDKRQLRLYQERYLADGDLHS 1129
EE + EE+ +E EE + + KK K +K ++ +E +++ + S
Sbjct: 2265 EEEERKEEEEGEEKQVEKEEEEKKKKKKEKKKEEVQEKEEVFEEKEEIMSEEETES 2320
Score = 38.9 bits (89), Expect = 0.033
Identities = 72/387 (18%), Positives = 156/387 (40%), Gaps = 36/387 (9%)
Query: 922 QAEKHLPRKSDKKENMEELLNLCSGKFTSQDASTPASSELNKQEKESSMGDPMEEALALC 981
Q E+ L + +K EE+L K ++ + L+ + KE D E L
Sbjct: 1491 QEEEKLHQAGEKLSPEEEMLQE-DKKLKWEEWKQVWENMLSSKSKEQQYKDEEEVTLEEE 1549
Query: 982 SGSFPTDKEEEDEEEEFGDFRLVSNDNEFDSDEDEHSDSGNDLALEDHEDDDEEELLKRS 1041
+KE++ EE+ R + ++++ + + + A E+ + EEE L +
Sbjct: 1550 VSREGEEKEQQVTEEQ----RHIQEEHKWARIHRKRARAEKKRAQEERKLAQEEEKLAQE 1605
Query: 1042 EKLKRQMRLRKYLEDEAEVSGSDVG-SEDEYDGEEIDEYEEDVIDEVLPSDEELQSQIKK 1100
E R+ ++E +++ + V ++D+ + + + + + E+L + +K
Sbjct: 1606 E--------RQLAQEERKLAQAYVKITQDDREMAQAEGKFAQKEETLAQRGEKLSQEAEK 1657
Query: 1101 IHMKTMLDDDKRQLRLYQERYLAD--GDLHS----------DGPGRMRKFRWKNIDDASQ 1148
+ K K + +E LA G L + P R + W+ + A +
Sbjct: 1658 LAQKRKKLAKKWEKVAREEEKLAKKGGKLAEVKNILAQKVEELPQREQNLDWQEKELAQE 1717
Query: 1149 MDLFHRDSDD-DQTEEQLDESEARWRKERIEREQWLRDMAQQGKITAEEEEEIGEDSQFM 1207
++ D ++ EE+L++ E + +E+ + + +A Q + +EEE ++ ++ + +
Sbjct: 1718 LEELEWDMEELSWKEEELNQEEGKLVEEKKKLAEEEEALAWQREKLSEEETKLAQEEELL 1777
Query: 1208 ILAKKVTAKALQK--------NASRPMVIQESKSLLRNPFEAIRPGSAQQVKTGSLLNQP 1259
I K+ A+ +K R +I E K L E + K +L Q
Sbjct: 1778 IQEKEKLAQHKEKMPEEEERLGRKREQLI-EKKMKLAQKRERWINSMEELTKNKMILYQK 1836
Query: 1260 KAVLQKLAALSDHNPSAPRNSRNFVFH 1286
K + Q+ L+ + N +++
Sbjct: 1837 KNLAQEKKNLAQEKEKLAQRKENLLYN 1863
Score = 33.9 bits (76), Expect = 1.1
Identities = 63/312 (20%), Positives = 119/312 (38%), Gaps = 59/312 (18%)
Query: 932 DKKENMEELLNLCSGKFTSQDASTPASSELNKQ-EKESSMGD---PMEEALALCSGSFPT 987
+ K EE + L GK T TP +S K + E + + +EE + L
Sbjct: 1966 EMKRLAEEKMRLVEGKETLSKGETPETSRQRKMTQVEQELFERKLSLEEKILLHEDRILA 2025
Query: 988 DKEEEDEEEEFGDFRLVSNDNEFDSDEDEHSDSGNDLALEDHEDDDEEELLKRSEKLKRQ 1047
+E E + G F + + + + L + E L K KL +
Sbjct: 2026 MEESEIAK---GKLEFTRGQRIFVQGQRKLAKASRKLIKK------RESLSKEPAKLNKI 2076
Query: 1048 MR-LRKYLEDEAEVSGSDVG-----------------SEDEYDGEEIDEYEEDVIDEVLP 1089
++ L+K DE +++ ++ + + D +E D E+ E+
Sbjct: 2077 LKALQKLTRDERKLTQEEIKMTKMKRALFVKERRLSIEQSKLDIKEWDFSEKR--SELTK 2134
Query: 1090 SDEELQSQIKKIHMK---------TMLDDDKRQLRLYQERYLAD---GDLHSDGPGRMRK 1137
+++L + +K+ K M +++ + R + E L D G + + K
Sbjct: 2135 DEKKLARKQRKLANKMRRMINKEEKMTEEESKLARKHSEVILDDEEEGGIEEEEVIPFLK 2194
Query: 1138 FRWKNIDDASQMD----LFHRDSDDDQTEEQLDESEARWRKERIEREQWLRDMAQQGKIT 1193
RW+ +A + D F D+ ++EE E E E L ++ +Q ++
Sbjct: 2195 RRWRKRKEAKRGDKPKEKFSSQVDEVESEEHFSE----------EMESLLDELEKQESLS 2244
Query: 1194 AEEEEEIGEDSQ 1205
+EEEEE E+ +
Sbjct: 2245 SEEEEEREEEEE 2256
Score = 33.1 bits (74), Expect = 1.8
Identities = 51/243 (20%), Positives = 101/243 (41%), Gaps = 45/243 (18%)
Query: 1002 RLVSNDNEFDSDEDEHSDSGNDLALEDHEDDDEEELLKRSEKLKRQMRLRKYLEDEAEVS 1061
RL ++ D E + S+ ++L DE++L ++ KL +MR + + E +++
Sbjct: 2110 RLSIEQSKLDIKEWDFSEKRSELT------KDEKKLARKQRKLANKMR--RMINKEEKMT 2161
Query: 1062 GSDVGSEDEYDGEEIDEYEEDVIDEVLPSDEELQSQIKKIHMKTMLDDDKRQLRLYQERY 1121
+ ++ +D+ EE I+E EE+ +K+ R + +
Sbjct: 2162 EEESKLARKHSEVILDDEEEGGIEE-----EEVIPFLKR--------------RWRKRKE 2202
Query: 1122 LADGDLHSDGPGRMRKFRWKNIDDASQMDLFHRDS----DDDQTEEQLDESEARWRKERI 1177
GD + KF +D+ + F + D+ + +E L E R+E
Sbjct: 2203 AKRGDKPKE------KFS-SQVDEVESEEHFSEEMESLLDELEKQESLSSEEEEEREEEE 2255
Query: 1178 EREQWLRDMAQQGKITAEEEEEIGEDSQFMILAKKVTAKALQKNASRPMVIQESKSLLRN 1237
ERE+ ++ ++ + EEEE GE+ Q + K+ K +K + +QE + +
Sbjct: 2256 EREE--EEVREEEEERKEEEE--GEEKQ---VEKEEEEKKKKKKEKKKEEVQEKEEVFEE 2308
Query: 1238 PFE 1240
E
Sbjct: 2309 KEE 2311
>gi|4503257 death-domain associated protein isoform a [Homo sapiens]
Length = 740
Score = 63.9 bits (154), Expect = 1e-09
Identities = 60/207 (28%), Positives = 96/207 (46%), Gaps = 28/207 (13%)
Query: 623 DNEDGFEEEEEEEEEMTDESEE--DGEEKVEKEEKEEELEEEEEKEEEEEEEGNQETAEF 680
D+ED E +EEEEEE +E EE D EE+ + E+ +E E++EE++EEEE ++ +
Sbjct: 436 DDEDDEESDEEEEEEEEEEEEEATDSEEEEDLEQMQEGQEDDEEEDEEEEAAAGKDGDKS 495
Query: 681 LLSSEEIETKDEKEMDKENNDGSSEIGKAVGFLSVPKSLSSDSTLLLFKDSSSKMGYFPT 740
+SS +I + E K+ + S E + G + P LS + P
Sbjct: 496 PMSSLQISNEKNLEPGKQISRSSGE-QQNKGRIVSPSLLSEE----------------PL 538
Query: 741 EEKSETDENSGKQPSKLDEDDSCSLLTKESSHNSSFELIGSTIPSYQPCNRQTGRGTSFF 800
S E++G+QP +L L +ES + FEL +P P + +T +S
Sbjct: 539 APSSIDAESNGEQPEEL-------TLEEESPVSQLFELEIEALPLDTPSSVETDISSSRK 591
Query: 801 PTAGGFRSPSPGLFRASLVSSASKSSG 827
+ F + A +VSS S + G
Sbjct: 592 QSEEPFTTVLEN--GAGMVSSTSFNGG 616
Score = 35.8 bits (81), Expect = 0.28
Identities = 31/120 (25%), Positives = 54/120 (45%), Gaps = 9/120 (7%)
Query: 949 TSQDASTPASSELNKQEKESSMGDPMEEALALCSGSFPTDKEEEDEEEEFGDFRLVSNDN 1008
+S A TP +S L+ E S M + S + D+++E+ +EE + +
Sbjct: 402 SSHSADTPEAS-LDSGEGPSGMAS---QGCPSASRAETDDEDDEESDEEEEEEEEEEEEE 457
Query: 1009 EFDSDEDEHSDSGNDLALEDHEDDDEEELL-----KRSEKLKRQMRLRKYLEDEAEVSGS 1063
DS+E+E + + +D E+D+EEE +S Q+ K LE ++S S
Sbjct: 458 ATDSEEEEDLEQMQEGQEDDEEEDEEEEAAAGKDGDKSPMSSLQISNEKNLEPGKQISRS 517
Score = 35.0 bits (79), Expect = 0.48
Identities = 61/268 (22%), Positives = 99/268 (36%), Gaps = 39/268 (14%)
Query: 1058 AEVSGSDVGSEDEYDGEEIDEYEEDVIDEVLPSDEELQSQIKKIHMKTMLDDDKRQLRLY 1117
AE D DE + EE +E EE+ D +E+L+ M+ +DD+ +
Sbjct: 433 AETDDEDDEESDEEEEEEEEEEEEEATDS--EEEEDLE------QMQEGQEDDEEEDE-- 482
Query: 1118 QERYLADGDLHSDGPGRMRKFRWKNIDDASQMDLFHRDSDDDQTEEQLDE----SEARWR 1173
+E A D ++ KN++ Q+ R S + Q + ++ SE
Sbjct: 483 EEEAAAGKDGDKSPMSSLQISNEKNLEPGKQIS---RSSGEQQNKGRIVSPSLLSEEPLA 539
Query: 1174 KERIEREQWLRDMAQQGKITAEEEEEIGEDSQFMILAKKVTAKALQKNASRPMVIQESKS 1233
I+ E + Q ++T EEE + + + ++ A L +S I S+
Sbjct: 540 PSSIDAES---NGEQPEELTLEEESPVSQ-----LFELEIEALPLDTPSSVETDISSSRK 591
Query: 1234 LLRNPFEAIRPGSAQQVKTGSLLNQPKAVLQKLAALSDHN--PSAP--RNSRNFVFHTLS 1289
PF + A V + S +S HN S P + SR T S
Sbjct: 592 QSEEPFTTVLENGAGMVSSTSF----------NGGVSPHNWGDSGPPCKKSRKEKKQTGS 641
Query: 1290 PVKAEAAKESSKSQVKKRGPSFMTSPSP 1317
+ E +S +K G T PSP
Sbjct: 642 GPLGNSYVERQRSVHEKNGKKICTLPSP 669
Score = 33.1 bits (74), Expect = 1.8
Identities = 36/127 (28%), Positives = 57/127 (44%), Gaps = 16/127 (12%)
Query: 20 SQEEADSPS---DSGQGSYETIGPLSEGDSDEEIFVSKKLKNRKVLQDSDSETEDTNASP 76
S AD+P DSG+G G S+G S+ + + ++SD E E+
Sbjct: 402 SSHSADTPEASLDSGEGPS---GMASQGCPS----ASRAETDDEDDEESDEEEEEEEEEE 454
Query: 77 EKTTYDSAEEENKENLYAGKNTKIKRIYKTVA----DSDESYMEKSLYQENLEAQVKPCL 132
E+ DS EEE+ E + G+ + + A D D+S M S Q + E ++P
Sbjct: 455 EEEATDSEEEEDLEQMQEGQEDDEEEDEEEEAAAGKDGDKSPM--SSLQISNEKNLEPGK 512
Query: 133 ELSLQSG 139
++S SG
Sbjct: 513 QISRSSG 519
Score = 32.7 bits (73), Expect = 2.4
Identities = 47/198 (23%), Positives = 80/198 (40%), Gaps = 25/198 (12%)
Query: 1130 DGPGRMRKFRWKNIDDASQMDLFHRDSDDDQTEEQLDESEARWRKERIEREQWLRDMAQQ 1189
+GP M + A D +SD+++ EE+ +E E E E+ L M Q+
Sbjct: 417 EGPSGMASQGCPSASRAETDDEDDEESDEEEEEEEEEEEE---EATDSEEEEDLEQM-QE 472
Query: 1190 GKITAEEEEEIGEDSQFMILAKKVTAKALQKNASRPMVIQESKSLLRNPFEAIRPGSAQQ 1249
G+ EEE+E E K K+ + I K+L P + I S +Q
Sbjct: 473 GQEDDEEEDEEEE---------AAAGKDGDKSPMSSLQISNEKNL--EPGKQISRSSGEQ 521
Query: 1250 VKTGSLLNQPKAVLQKLAALSDHNPSAPRNSRNFVFHTLSPVKAEAAKESSKSQVKKRGP 1309
G +++ +L P AP +S + + P + +ES SQ+ +
Sbjct: 522 QNKGRIVS---------PSLLSEEPLAP-SSIDAESNGEQPEELTLEEESPVSQLFELEI 571
Query: 1310 SFMTSPSPKHLKTDDSTS 1327
+ +P ++TD S+S
Sbjct: 572 EALPLDTPSSVETDISSS 589
>gi|215422388 death-domain associated protein isoform a [Homo
sapiens]
Length = 740
Score = 63.9 bits (154), Expect = 1e-09
Identities = 60/207 (28%), Positives = 96/207 (46%), Gaps = 28/207 (13%)
Query: 623 DNEDGFEEEEEEEEEMTDESEE--DGEEKVEKEEKEEELEEEEEKEEEEEEEGNQETAEF 680
D+ED E +EEEEEE +E EE D EE+ + E+ +E E++EE++EEEE ++ +
Sbjct: 436 DDEDDEESDEEEEEEEEEEEEEATDSEEEEDLEQMQEGQEDDEEEDEEEEAAAGKDGDKS 495
Query: 681 LLSSEEIETKDEKEMDKENNDGSSEIGKAVGFLSVPKSLSSDSTLLLFKDSSSKMGYFPT 740
+SS +I + E K+ + S E + G + P LS + P
Sbjct: 496 PMSSLQISNEKNLEPGKQISRSSGE-QQNKGRIVSPSLLSEE----------------PL 538
Query: 741 EEKSETDENSGKQPSKLDEDDSCSLLTKESSHNSSFELIGSTIPSYQPCNRQTGRGTSFF 800
S E++G+QP +L L +ES + FEL +P P + +T +S
Sbjct: 539 APSSIDAESNGEQPEEL-------TLEEESPVSQLFELEIEALPLDTPSSVETDISSSRK 591
Query: 801 PTAGGFRSPSPGLFRASLVSSASKSSG 827
+ F + A +VSS S + G
Sbjct: 592 QSEEPFTTVLEN--GAGMVSSTSFNGG 616
Score = 35.8 bits (81), Expect = 0.28
Identities = 31/120 (25%), Positives = 54/120 (45%), Gaps = 9/120 (7%)
Query: 949 TSQDASTPASSELNKQEKESSMGDPMEEALALCSGSFPTDKEEEDEEEEFGDFRLVSNDN 1008
+S A TP +S L+ E S M + S + D+++E+ +EE + +
Sbjct: 402 SSHSADTPEAS-LDSGEGPSGMAS---QGCPSASRAETDDEDDEESDEEEEEEEEEEEEE 457
Query: 1009 EFDSDEDEHSDSGNDLALEDHEDDDEEELL-----KRSEKLKRQMRLRKYLEDEAEVSGS 1063
DS+E+E + + +D E+D+EEE +S Q+ K LE ++S S
Sbjct: 458 ATDSEEEEDLEQMQEGQEDDEEEDEEEEAAAGKDGDKSPMSSLQISNEKNLEPGKQISRS 517
Score = 35.0 bits (79), Expect = 0.48
Identities = 61/268 (22%), Positives = 99/268 (36%), Gaps = 39/268 (14%)
Query: 1058 AEVSGSDVGSEDEYDGEEIDEYEEDVIDEVLPSDEELQSQIKKIHMKTMLDDDKRQLRLY 1117
AE D DE + EE +E EE+ D +E+L+ M+ +DD+ +
Sbjct: 433 AETDDEDDEESDEEEEEEEEEEEEEATDS--EEEEDLE------QMQEGQEDDEEEDE-- 482
Query: 1118 QERYLADGDLHSDGPGRMRKFRWKNIDDASQMDLFHRDSDDDQTEEQLDE----SEARWR 1173
+E A D ++ KN++ Q+ R S + Q + ++ SE
Sbjct: 483 EEEAAAGKDGDKSPMSSLQISNEKNLEPGKQIS---RSSGEQQNKGRIVSPSLLSEEPLA 539
Query: 1174 KERIEREQWLRDMAQQGKITAEEEEEIGEDSQFMILAKKVTAKALQKNASRPMVIQESKS 1233
I+ E + Q ++T EEE + + + ++ A L +S I S+
Sbjct: 540 PSSIDAES---NGEQPEELTLEEESPVSQ-----LFELEIEALPLDTPSSVETDISSSRK 591
Query: 1234 LLRNPFEAIRPGSAQQVKTGSLLNQPKAVLQKLAALSDHN--PSAP--RNSRNFVFHTLS 1289
PF + A V + S +S HN S P + SR T S
Sbjct: 592 QSEEPFTTVLENGAGMVSSTSF----------NGGVSPHNWGDSGPPCKKSRKEKKQTGS 641
Query: 1290 PVKAEAAKESSKSQVKKRGPSFMTSPSP 1317
+ E +S +K G T PSP
Sbjct: 642 GPLGNSYVERQRSVHEKNGKKICTLPSP 669
Score = 33.1 bits (74), Expect = 1.8
Identities = 36/127 (28%), Positives = 57/127 (44%), Gaps = 16/127 (12%)
Query: 20 SQEEADSPS---DSGQGSYETIGPLSEGDSDEEIFVSKKLKNRKVLQDSDSETEDTNASP 76
S AD+P DSG+G G S+G S+ + + ++SD E E+
Sbjct: 402 SSHSADTPEASLDSGEGPS---GMASQGCPS----ASRAETDDEDDEESDEEEEEEEEEE 454
Query: 77 EKTTYDSAEEENKENLYAGKNTKIKRIYKTVA----DSDESYMEKSLYQENLEAQVKPCL 132
E+ DS EEE+ E + G+ + + A D D+S M S Q + E ++P
Sbjct: 455 EEEATDSEEEEDLEQMQEGQEDDEEEDEEEEAAAGKDGDKSPM--SSLQISNEKNLEPGK 512
Query: 133 ELSLQSG 139
++S SG
Sbjct: 513 QISRSSG 519
Score = 32.7 bits (73), Expect = 2.4
Identities = 47/198 (23%), Positives = 80/198 (40%), Gaps = 25/198 (12%)
Query: 1130 DGPGRMRKFRWKNIDDASQMDLFHRDSDDDQTEEQLDESEARWRKERIEREQWLRDMAQQ 1189
+GP M + A D +SD+++ EE+ +E E E E+ L M Q+
Sbjct: 417 EGPSGMASQGCPSASRAETDDEDDEESDEEEEEEEEEEEE---EATDSEEEEDLEQM-QE 472
Query: 1190 GKITAEEEEEIGEDSQFMILAKKVTAKALQKNASRPMVIQESKSLLRNPFEAIRPGSAQQ 1249
G+ EEE+E E K K+ + I K+L P + I S +Q
Sbjct: 473 GQEDDEEEDEEEE---------AAAGKDGDKSPMSSLQISNEKNL--EPGKQISRSSGEQ 521
Query: 1250 VKTGSLLNQPKAVLQKLAALSDHNPSAPRNSRNFVFHTLSPVKAEAAKESSKSQVKKRGP 1309
G +++ +L P AP +S + + P + +ES SQ+ +
Sbjct: 522 QNKGRIVS---------PSLLSEEPLAP-SSIDAESNGEQPEELTLEEESPVSQLFELEI 571
Query: 1310 SFMTSPSPKHLKTDDSTS 1327
+ +P ++TD S+S
Sbjct: 572 EALPLDTPSSVETDISSS 589
>gi|215422366 death-domain associated protein isoform b [Homo
sapiens]
Length = 752
Score = 63.9 bits (154), Expect = 1e-09
Identities = 60/207 (28%), Positives = 96/207 (46%), Gaps = 28/207 (13%)
Query: 623 DNEDGFEEEEEEEEEMTDESEE--DGEEKVEKEEKEEELEEEEEKEEEEEEEGNQETAEF 680
D+ED E +EEEEEE +E EE D EE+ + E+ +E E++EE++EEEE ++ +
Sbjct: 448 DDEDDEESDEEEEEEEEEEEEEATDSEEEEDLEQMQEGQEDDEEEDEEEEAAAGKDGDKS 507
Query: 681 LLSSEEIETKDEKEMDKENNDGSSEIGKAVGFLSVPKSLSSDSTLLLFKDSSSKMGYFPT 740
+SS +I + E K+ + S E + G + P LS + P
Sbjct: 508 PMSSLQISNEKNLEPGKQISRSSGE-QQNKGRIVSPSLLSEE----------------PL 550
Query: 741 EEKSETDENSGKQPSKLDEDDSCSLLTKESSHNSSFELIGSTIPSYQPCNRQTGRGTSFF 800
S E++G+QP +L L +ES + FEL +P P + +T +S
Sbjct: 551 APSSIDAESNGEQPEEL-------TLEEESPVSQLFELEIEALPLDTPSSVETDISSSRK 603
Query: 801 PTAGGFRSPSPGLFRASLVSSASKSSG 827
+ F + A +VSS S + G
Sbjct: 604 QSEEPFTTVLEN--GAGMVSSTSFNGG 628
Score = 35.8 bits (81), Expect = 0.28
Identities = 31/120 (25%), Positives = 54/120 (45%), Gaps = 9/120 (7%)
Query: 949 TSQDASTPASSELNKQEKESSMGDPMEEALALCSGSFPTDKEEEDEEEEFGDFRLVSNDN 1008
+S A TP +S L+ E S M + S + D+++E+ +EE + +
Sbjct: 414 SSHSADTPEAS-LDSGEGPSGMAS---QGCPSASRAETDDEDDEESDEEEEEEEEEEEEE 469
Query: 1009 EFDSDEDEHSDSGNDLALEDHEDDDEEELL-----KRSEKLKRQMRLRKYLEDEAEVSGS 1063
DS+E+E + + +D E+D+EEE +S Q+ K LE ++S S
Sbjct: 470 ATDSEEEEDLEQMQEGQEDDEEEDEEEEAAAGKDGDKSPMSSLQISNEKNLEPGKQISRS 529
Score = 35.0 bits (79), Expect = 0.48
Identities = 61/268 (22%), Positives = 99/268 (36%), Gaps = 39/268 (14%)
Query: 1058 AEVSGSDVGSEDEYDGEEIDEYEEDVIDEVLPSDEELQSQIKKIHMKTMLDDDKRQLRLY 1117
AE D DE + EE +E EE+ D +E+L+ M+ +DD+ +
Sbjct: 445 AETDDEDDEESDEEEEEEEEEEEEEATDS--EEEEDLE------QMQEGQEDDEEEDE-- 494
Query: 1118 QERYLADGDLHSDGPGRMRKFRWKNIDDASQMDLFHRDSDDDQTEEQLDE----SEARWR 1173
+E A D ++ KN++ Q+ R S + Q + ++ SE
Sbjct: 495 EEEAAAGKDGDKSPMSSLQISNEKNLEPGKQIS---RSSGEQQNKGRIVSPSLLSEEPLA 551
Query: 1174 KERIEREQWLRDMAQQGKITAEEEEEIGEDSQFMILAKKVTAKALQKNASRPMVIQESKS 1233
I+ E + Q ++T EEE + + + ++ A L +S I S+
Sbjct: 552 PSSIDAES---NGEQPEELTLEEESPVSQ-----LFELEIEALPLDTPSSVETDISSSRK 603
Query: 1234 LLRNPFEAIRPGSAQQVKTGSLLNQPKAVLQKLAALSDHN--PSAP--RNSRNFVFHTLS 1289
PF + A V + S +S HN S P + SR T S
Sbjct: 604 QSEEPFTTVLENGAGMVSSTSF----------NGGVSPHNWGDSGPPCKKSRKEKKQTGS 653
Query: 1290 PVKAEAAKESSKSQVKKRGPSFMTSPSP 1317
+ E +S +K G T PSP
Sbjct: 654 GPLGNSYVERQRSVHEKNGKKICTLPSP 681
Score = 33.1 bits (74), Expect = 1.8
Identities = 36/127 (28%), Positives = 57/127 (44%), Gaps = 16/127 (12%)
Query: 20 SQEEADSPS---DSGQGSYETIGPLSEGDSDEEIFVSKKLKNRKVLQDSDSETEDTNASP 76
S AD+P DSG+G G S+G S+ + + ++SD E E+
Sbjct: 414 SSHSADTPEASLDSGEGPS---GMASQGCPS----ASRAETDDEDDEESDEEEEEEEEEE 466
Query: 77 EKTTYDSAEEENKENLYAGKNTKIKRIYKTVA----DSDESYMEKSLYQENLEAQVKPCL 132
E+ DS EEE+ E + G+ + + A D D+S M S Q + E ++P
Sbjct: 467 EEEATDSEEEEDLEQMQEGQEDDEEEDEEEEAAAGKDGDKSPM--SSLQISNEKNLEPGK 524
Query: 133 ELSLQSG 139
++S SG
Sbjct: 525 QISRSSG 531
Score = 32.7 bits (73), Expect = 2.4
Identities = 47/198 (23%), Positives = 80/198 (40%), Gaps = 25/198 (12%)
Query: 1130 DGPGRMRKFRWKNIDDASQMDLFHRDSDDDQTEEQLDESEARWRKERIEREQWLRDMAQQ 1189
+GP M + A D +SD+++ EE+ +E E E E+ L M Q+
Sbjct: 429 EGPSGMASQGCPSASRAETDDEDDEESDEEEEEEEEEEEE---EATDSEEEEDLEQM-QE 484
Query: 1190 GKITAEEEEEIGEDSQFMILAKKVTAKALQKNASRPMVIQESKSLLRNPFEAIRPGSAQQ 1249
G+ EEE+E E K K+ + I K+L P + I S +Q
Sbjct: 485 GQEDDEEEDEEEE---------AAAGKDGDKSPMSSLQISNEKNL--EPGKQISRSSGEQ 533
Query: 1250 VKTGSLLNQPKAVLQKLAALSDHNPSAPRNSRNFVFHTLSPVKAEAAKESSKSQVKKRGP 1309
G +++ +L P AP +S + + P + +ES SQ+ +
Sbjct: 534 QNKGRIVS---------PSLLSEEPLAP-SSIDAESNGEQPEELTLEEESPVSQLFELEI 583
Query: 1310 SFMTSPSPKHLKTDDSTS 1327
+ +P ++TD S+S
Sbjct: 584 EALPLDTPSSVETDISSS 601
>gi|34878904 synaptonemal complex protein 1 [Homo sapiens]
Length = 976
Score = 63.2 bits (152), Expect = 2e-09
Identities = 162/786 (20%), Positives = 317/786 (40%), Gaps = 136/786 (17%)
Query: 53 SKKLKNRKVLQDSDSETEDTNASPEKTTYDSAE--EENKENLYAGKNTK-----IKRIYK 105
SK +NRK+++ ++ EK + E +ENK+ + T+ +K
Sbjct: 132 SKLQENRKIIEAQRKAIQELQFGNEKVSLKLEEGIQENKDLIKENNATRHLCNLLKETCA 191
Query: 106 TVADSDESYM-----EKSLYQE---NLEAQVKPCLELSLQSGNST---------DFTTDR 148
A+ + Y + +Y + N+E + EL +Q+ NS D+ +
Sbjct: 192 RSAEKTKKYEYEREETRQVYMDLNNNIEKMITAFEELRVQAENSRLEMHFKLKEDYEKIQ 251
Query: 149 ---KSSKKHIHDKEG---------TAGKAKVKSKRRLEKEERKMEKIRQLKKKETKNQED 196
+ KK I+DKE T + K+K L +E R +K+ QL++K TK Q +
Sbjct: 252 HLEQEYKKEINDKEKQVSLLLIQITEKENKMKDLTFLLEESR--DKVNQLEEK-TKLQSE 308
Query: 197 DVEQPFNDSGCLLVDKDLFETGLEDENNSPLEDEESLESIRAAVKNKVKKHKKKEPSLES 256
+++Q L + + + L+ ++ EE L+ A K + ++KE +E
Sbjct: 309 NLKQSIEKQHHLTKELEDIKVSLQRSVSTQKALEEDLQ---IATKTICQLTEEKETQMEE 365
Query: 257 G----------VHSFEEGSELSKGTTRKERKAARLSKEALKQLHSETQRLIRESALNLPY 306
V FE + R E++ +++ LK L E Q+ + S L
Sbjct: 366 SNKARAAHSFVVTEFETTVCSLEELLRTEQQRLEKNEDQLKILTMELQK--KSSELEEMT 423
Query: 307 HMPENKTIH-DFFKR----------------KPRPTCHGNAMAL--LKSSKYQSSHHKEI 347
+ NK + + K+ K G L L ++ + H EI
Sbjct: 424 KLTNNKEVELEELKKVLGEKETLLYENKQFEKIAEELKGTEQELIGLLQAREKEVHDLEI 483
Query: 348 IDTANTTEMNSDHHSKGSEQTTGAENEVETNALPVVSKETQIITGSDESCRKDLVKNEEL 407
TA TT + ++SK + + E+E L K T++ + C K ++N+EL
Sbjct: 484 QLTAITT--SEQYYSK---EVKDLKTELENEKL----KNTELTS----HCNKLSLENKEL 530
Query: 408 E-------IQEKQKQSDIRPSPGDSSVLQQESNFLGNNHSEECQVGGLVAFEPHALEGEG 460
++ K +Q DI + + ++ + N E Q+ + + L+
Sbjct: 531 TQETSDMTLELKNQQEDINNNKKQEERMLKQ---IENLQETETQLRNELEYVREELK--- 584
Query: 461 PQNPEETDEKVEEPEQQNKSSAVGPPEKVRRFTLDRLKQLGVDVSIKPRLGADEDSFVIL 520
Q +E K+++ E+ N ++ E ++ ++ L+Q + ++K + A+ +
Sbjct: 585 -QKRDEVKCKLDKSEE-NCNNLRKQVENKNKY-IEELQQ--ENKALKKKGTAESKQLNVY 639
Query: 521 EPETNR---ELEALKQRFWKHANPAAKPRAGQTVNVNVIVKDMGTDGKEELKADVVPVTL 577
E + N+ ELE+ KQ+F + + K + ++ +++++ E+ K
Sbjct: 640 EIKVNKLELELESAKQKFGEITDTYQKEIEDKKISEENLLEEV-----EKAKVIADEAVK 694
Query: 578 APKKLDGASHTKPGEKLQVLKAKLQEAMKLRRFEERQKRQALFKLDNEDGFEEEEEEEEE 637
K++D K E + +++ + K+ EER L+K ++ E E
Sbjct: 695 LQKEIDKRCQHKIAEMVALMEKHKHQYDKI--IEERDSELGLYKSKEQEQSSLRASLEIE 752
Query: 638 MTDESEE----DGEEKVEKEEKEEELEEEEEKEEEEEEEGNQETAEFLLSSEEIETK-DE 692
+++ E + ++E+EEKE+ E +E +E+ +++T FLL + EI K D
Sbjct: 753 LSNLKAELLSVKKQLEIEREEKEKLKREAKENTATLKEKKDKKTQTFLLETPEIYWKLDS 812
Query: 693 KEMDKENNDGSSEIGKAVGFLSVPKSLSSDSTLLLFKDSSSKMG---------YFPTEEK 743
K + + + F SV +S D L+ + + + PT+ K
Sbjct: 813 KAVPSQT--------VSRNFTSVDHGISKDKRDYLWTSAKNTLSTPLPKAYTVKTPTKPK 864
Query: 744 SETDEN 749
+ EN
Sbjct: 865 LQQREN 870
Score = 36.2 bits (82), Expect = 0.22
Identities = 40/151 (26%), Positives = 70/151 (46%), Gaps = 13/151 (8%)
Query: 606 KLRRFEERQKRQALFKL--DNEDGFEEEEEEEEEMTDESEEDGEEKVEKEEKEEELEEEE 663
+LR E + + FKL D E E+E ++E+ D+ ++ ++ EKE ++++
Sbjct: 227 ELRVQAENSRLEMHFKLKEDYEKIQHLEQEYKKEINDKEKQVSLLLIQITEKENKMKDLT 286
Query: 664 EKEEEEEEEGNQETAEFLLSSEEIETKDEKE--MDKENNDGSSEIGKAVGFLSVPKSLSS 721
EE ++ NQ + L SE ++ EK+ + KE D + ++V S K+L
Sbjct: 287 FLLEESRDKVNQLEEKTKLQSENLKQSIEKQHHLTKELEDIKVSLQRSV---STQKALEE 343
Query: 722 DSTLLLFKDSSSKMGYFPTEEKSETDENSGK 752
D + ++K TEEK E S K
Sbjct: 344 DLQI------ATKTICQLTEEKETQMEESNK 368
>gi|239745093 PREDICTED: hypothetical protein XP_002343359 [Homo
sapiens]
Length = 142
Score = 62.8 bits (151), Expect = 2e-09
Identities = 32/70 (45%), Positives = 48/70 (68%), Gaps = 1/70 (1%)
Query: 625 EDGFEEEEEEEEEMTDESEEDGEEKVEKEEKEEELEEEEEKEEEEEEEGNQETAEFLLSS 684
E+ EE+ EE+ +E +G+ + ++EEKEEE EEEEE+EEEEEEE +E F L++
Sbjct: 69 EEKRREEKRREEKRREEKRREGKRREKEEEKEEEEEEEEEEEEEEEEE-EEEEVSFSLAT 127
Query: 685 EEIETKDEKE 694
E ET+ E++
Sbjct: 128 RERETETEEK 137
Score = 44.7 bits (104), Expect = 6e-04
Identities = 25/76 (32%), Positives = 44/76 (57%), Gaps = 3/76 (3%)
Query: 599 AKLQEAMKLRRFEERQKRQALFKLDNEDGFEEEEEEEEEMTDESEEDGEEKVEKEEKEE- 657
A+ + + +R EE+++ + + +G E+EEE+E +E EE+ EE+ E+EE+EE
Sbjct: 62 ARKSQRREEKRREEKRREEKRREEKRREGKRREKEEEKEEEEEEEEEEEEEEEEEEEEEV 121
Query: 658 --ELEEEEEKEEEEEE 671
L E + E EE+
Sbjct: 122 SFSLATRERETETEEK 137
Score = 43.9 bits (102), Expect = 0.001
Identities = 28/84 (33%), Positives = 48/84 (57%), Gaps = 5/84 (5%)
Query: 587 HTKPGEKLQVLKAKLQEAMKLRRFEER---QKRQALFKLDNEDGFEEEEEEEEEMTDESE 643
H+ G + + + ++ + +R EE+ +KR+ + + E+ EEEEEEEEE +E E
Sbjct: 55 HSMAGTSARKSQRREEKRREEKRREEKRREEKRREGKRREKEEEKEEEEEEEEEEEEEEE 114
Query: 644 EDGEEKV--EKEEKEEELEEEEEK 665
E+ EE+V +E E E EE++
Sbjct: 115 EEEEEEVSFSLATRERETETEEKR 138
Score = 40.4 bits (93), Expect = 0.012
Identities = 24/79 (30%), Positives = 41/79 (51%)
Query: 584 GASHTKPGEKLQVLKAKLQEAMKLRRFEERQKRQALFKLDNEDGFEEEEEEEEEMTDESE 643
G S K + + + + + K R + R+ ++ + + E+ EEEEEEEEE +E E
Sbjct: 59 GTSARKSQRREEKRREEKRREEKRREEKRREGKRREKEEEKEEEEEEEEEEEEEEEEEEE 118
Query: 644 EDGEEKVEKEEKEEELEEE 662
E+ + E+E E EE+
Sbjct: 119 EEVSFSLATRERETETEEK 137
Score = 38.1 bits (87), Expect = 0.057
Identities = 30/139 (21%), Positives = 56/139 (40%), Gaps = 15/139 (10%)
Query: 968 SSMGDPMEEALALCSGSFPTDKEEEDEEEEFGDFRLVSNDNEFDSDEDE-----HSDSGN 1022
SS P + + L + +P K E L N S ++E HS +G
Sbjct: 11 SSASSPENDRILLSTFPYPHSKREN----------LAGLTNSTSSVKEEPPTLRHSMAGT 60
Query: 1023 DLALEDHEDDDEEELLKRSEKLKRQMRLRKYLEDEAEVSGSDVGSEDEYDGEEIDEYEED 1082
++ E +R EK + + R ++ E + E+E + EE +E EE+
Sbjct: 61 SARKSQRREEKRREEKRREEKRREEKRREGKRREKEEEKEEEEEEEEEEEEEEEEEEEEE 120
Query: 1083 VIDEVLPSDEELQSQIKKI 1101
V + + E +++ K++
Sbjct: 121 VSFSLATRERETETEEKRL 139
Score = 37.0 bits (84), Expect = 0.13
Identities = 32/120 (26%), Positives = 55/120 (45%), Gaps = 22/120 (18%)
Query: 140 NSTDFTTDRKSSKKHIHDKEGTAGKAKVKSKRRLEK---EERKMEKIRQLKKKETKNQED 196
NST + + +H AG + KS+RR EK E+R+ EK R+ K++E K +E
Sbjct: 41 NSTSSVKEEPPTLRH-----SMAGTSARKSQRREEKRREEKRREEKRREEKRREGKRREK 95
Query: 197 DVEQPFNDSGCLLVDKDLFETGLEDENNSPLEDEESLESIRAAVKNKVKKHKKKEPSLES 256
+ E+ E E+E E+EE E + ++ + ++ + +E L S
Sbjct: 96 EEEKE--------------EEEEEEEEEEEEEEEEEEEEVSFSLATRERETETEEKRLIS 141
>gi|5454088 acidic (leucine-rich) nuclear phosphoprotein 32 family,
member B [Homo sapiens]
Length = 251
Score = 62.8 bits (151), Expect = 2e-09
Identities = 49/162 (30%), Positives = 82/162 (50%), Gaps = 23/162 (14%)
Query: 561 GTDGKEELKADVVPVTLAPKKLDGASHTKPGEKLQVLKAKLQEAMKLRRFEERQKRQALF 620
G D E ++ + L+ KL S +P +KL+ LK+ + R+++F
Sbjct: 79 GLDMLAEKLPNLTHLNLSGNKLKDISTLEPLKKLECLKSL--DLFNCEVTNLNDYRESVF 136
Query: 621 KLDNE----DGFE----------------EEEEEEEEMTDESEEDGEEKVEKEEKEEELE 660
KL + DG++ +EEEE+EE DE +ED E+ E+E EE+ E
Sbjct: 137 KLLPQLTYLDGYDREDQEAPDSDAEVDGVDEEEEDEEGEDEEDEDDEDGEEEEFDEEDDE 196
Query: 661 EEEEKEEEEEEEGNQETAEFLLSSEEIETKDEKEMDKENNDG 702
+E+ + +E+++E ++E EF L EE E +DE E ++E G
Sbjct: 197 DEDVEGDEDDDEVSEEEEEFGL-DEEDEDEDEDEEEEEGGKG 237
Score = 51.6 bits (122), Expect = 5e-06
Identities = 32/74 (43%), Positives = 44/74 (59%), Gaps = 3/74 (4%)
Query: 623 DNEDGFEEEEEEEEEMTDESEEDGEEKVEKEEKEEELEEEEEKEEEEEEEGNQETAEFLL 682
D+EDG EEEE +EE+ DE E E+ E E+EEE +EE E+E+E+E +E +
Sbjct: 181 DDEDG-EEEEFDEEDDEDEDVEGDEDDDEVSEEEEEFGLDEEDEDEDEDEEEEEGGKG-- 237
Query: 683 SSEEIETKDEKEMD 696
+ ET DE E D
Sbjct: 238 EKRKRETDDEGEDD 251
Score = 43.1 bits (100), Expect = 0.002
Identities = 27/70 (38%), Positives = 39/70 (55%), Gaps = 5/70 (7%)
Query: 983 GSFPTDKEEED-EEEEFGDFRLVSNDNEFDSDEDEHSDSGNDLAL----EDHEDDDEEEL 1037
G D+++ED EEEEF + D E D D+DE S+ + L ED ++D+EEE
Sbjct: 174 GEDEEDEDDEDGEEEEFDEEDDEDEDVEGDEDDDEVSEEEEEFGLDEEDEDEDEDEEEEE 233
Query: 1038 LKRSEKLKRQ 1047
+ EK KR+
Sbjct: 234 GGKGEKRKRE 243
Score = 38.5 bits (88), Expect = 0.044
Identities = 26/95 (27%), Positives = 43/95 (45%), Gaps = 13/95 (13%)
Query: 988 DKEEEDEEEEFGDFRLVSNDNEFDSDEDEHSDSGNDLALEDHEDDDEEELLKRSEKLKRQ 1047
D+E D + E D E + +EDE + G + E E+DDE+E ++ E
Sbjct: 152 DQEAPDSDAEVDGVDEEEEDEEGEDEEDEDDEDGEE--EEFDEEDDEDEDVEGDED---- 205
Query: 1048 MRLRKYLEDEAEVSGSDVGSEDEYDGEEIDEYEED 1082
+DE + G ++E + E+ DE EE+
Sbjct: 206 -------DDEVSEEEEEFGLDEEDEDEDEDEEEEE 233
Score = 38.5 bits (88), Expect = 0.044
Identities = 29/95 (30%), Positives = 44/95 (46%), Gaps = 10/95 (10%)
Query: 988 DKEEEDEEEEFGDFRLVSNDNEFDSDEDEHSDSGNDLALEDHEDDDEEELLKRSEKLKRQ 1047
D+EEEDEE E ++E D D +E D ED E D++++ + E+ +
Sbjct: 166 DEEEEDEEGE-------DEEDEDDEDGEEEEFDEEDDEDEDVEGDEDDDEVSEEEE---E 215
Query: 1048 MRLRKYLEDEAEVSGSDVGSEDEYDGEEIDEYEED 1082
L + EDE E + G + E E D+ ED
Sbjct: 216 FGLDEEDEDEDEDEEEEEGGKGEKRKRETDDEGED 250
Score = 37.7 bits (86), Expect = 0.075
Identities = 24/96 (25%), Positives = 48/96 (50%), Gaps = 5/96 (5%)
Query: 581 KLDGASHTKPGEKLQVLKAKLQEAMKLRRFEERQKRQALFKLDNEDGFEEEEEEEEEMTD 640
++DG + E+ + + + E + F+E + D +D EEEEE + +
Sbjct: 161 EVDGVDEEEEDEEGEDEEDEDDEDGEEEEFDEEDDEDEDVEGDEDDDEVSEEEEEFGLDE 220
Query: 641 ESEEDGEEKVEKEEKEEELEEEEEKEEEEEEEGNQE 676
E E++ E +E+EEE + E+++ E ++EG +
Sbjct: 221 EDEDEDE-----DEEEEEGGKGEKRKRETDDEGEDD 251
Score = 35.0 bits (79), Expect = 0.48
Identities = 24/96 (25%), Positives = 44/96 (45%), Gaps = 1/96 (1%)
Query: 1055 EDEAEVSGSDVGSEDEYDGEEIDEYEEDVIDEVLPSDEELQSQIKKIHMKTMLDDDKRQL 1114
+ +AEV G D EDE +E DE +ED +E +++ ++ + +++ +
Sbjct: 157 DSDAEVDGVDEEEEDEEGEDEEDEDDEDGEEEEFDEEDDEDEDVEGDEDDDEVSEEEEEF 216
Query: 1115 RLYQERYLADGDLHSDGPGRMRKFRWKNIDDASQMD 1150
L +E D D + G+ K R + DD + D
Sbjct: 217 GLDEEDEDEDEDEEEEEGGKGEK-RKRETDDEGEDD 251
>gi|169210053 PREDICTED: hypothetical protein [Homo sapiens]
Length = 185
Score = 61.2 bits (147), Expect = 6e-09
Identities = 35/65 (53%), Positives = 45/65 (69%), Gaps = 2/65 (3%)
Query: 629 EEEEEEEEEMTDESEEDGEEKVEKEEKEEELEEEEEKEEEEEEEGNQETAEFLLSSEEIE 688
EEEE EEEE E EE EEK E EE+EE+ EE+EE EEEEE+EG + E + EEI+
Sbjct: 119 EEEEVEEEEEEVEEEEKEEEKEEDEEEEEKEEEKEEDEEEEEKEGKKMEEEKV--EEEID 176
Query: 689 TKDEK 693
T+ ++
Sbjct: 177 TEIQR 181
Score = 55.8 bits (133), Expect = 3e-07
Identities = 33/64 (51%), Positives = 44/64 (68%), Gaps = 4/64 (6%)
Query: 635 EEEMTDESEEDGEEKVEKEEKEEELEEEEEKEEEEEEEGNQETAEFLLSSEEIETKDEKE 694
EEE +E EE+ EE+ ++EEKEE+ EEEEEKEEE+EE+ +E E EE K E+E
Sbjct: 119 EEEEVEEEEEEVEEEEKEEEKEED-EEEEEKEEEKEEDEEEEEKEGKKMEEE---KVEEE 174
Query: 695 MDKE 698
+D E
Sbjct: 175 IDTE 178
Score = 51.2 bits (121), Expect = 7e-06
Identities = 34/69 (49%), Positives = 44/69 (63%), Gaps = 18/69 (26%)
Query: 630 EEEEEEEEMTDESEEDGEEKVEKEEKEEELEEEEEKEEEEEEEGNQETAEFLLSSEEIET 689
EEEE EEE EE+VE+EEKEEE EE+EE EEE+EEE ++ EE E
Sbjct: 119 EEEEVEEE---------EEEVEEEEKEEEKEEDEE-EEEKEEEKEED--------EEEEE 160
Query: 690 KDEKEMDKE 698
K+ K+M++E
Sbjct: 161 KEGKKMEEE 169
Score = 45.8 bits (107), Expect = 3e-04
Identities = 26/56 (46%), Positives = 35/56 (62%)
Query: 650 VEKEEKEEELEEEEEKEEEEEEEGNQETAEFLLSSEEIETKDEKEMDKENNDGSSE 705
VE+EE EEE EE EE+E+EEE+E ++E E EE E ++EKE K + E
Sbjct: 118 VEEEEVEEEEEEVEEEEKEEEKEEDEEEEEKEEEKEEDEEEEEKEGKKMEEEKVEE 173
Score = 42.7 bits (99), Expect = 0.002
Identities = 35/120 (29%), Positives = 62/120 (51%), Gaps = 12/120 (10%)
Query: 553 VNVIVKDMGTD-----GKEELKADVVPVTLAPKKLDGASHTKPGEKLQVLKAKLQEAMKL 607
V + VKD G GK +L A +++A A + L V + +++E +
Sbjct: 71 VGLPVKDSGVSQAKIWGKNDLSAGN-RLSVARTAALVAEECSAQQGLPVEEEEVEEEEEE 129
Query: 608 RRFEERQKRQALFKLDNEDGFEEEEEEEEEMTDESEEDGEEKVEKEEKEEELEEEEEKEE 667
EE+++ + ED EEE+EEE+E +E EE +K+E+E+ EEE++ E ++ +
Sbjct: 130 VEEEEKEEEK------EEDEEEEEKEEEKEEDEEEEEKEGKKMEEEKVEEEIDTEIQRTQ 183
Score = 41.2 bits (95), Expect = 0.007
Identities = 25/60 (41%), Positives = 35/60 (58%), Gaps = 6/60 (10%)
Query: 642 SEEDGEEKVEKEEKEEELEEEEEKEEEEEEEGNQETAEFLLSSEEIETKDEKEMDKENND 701
+EE ++ E+EE EEEEE EEEE+EE +E EE E ++EKE D+E +
Sbjct: 107 AEECSAQQGLPVEEEEVEEEEEEVEEEEKEEEKEE------DEEEEEKEEEKEEDEEEEE 160
Score = 37.0 bits (84), Expect = 0.13
Identities = 22/55 (40%), Positives = 32/55 (58%), Gaps = 2/55 (3%)
Query: 651 EKEEKEEELEEEEEKEEEEEEEGNQETAEFLLSSEEIETKDEKEMDKENNDGSSE 705
E+ ++ L EEE+ EEEEEE +E E EE E ++EKE +KE ++ E
Sbjct: 108 EECSAQQGLPVEEEEVEEEEEEVEEEEKE--EEKEEDEEEEEKEEEKEEDEEEEE 160
Score = 35.0 bits (79), Expect = 0.48
Identities = 17/63 (26%), Positives = 34/63 (53%), Gaps = 4/63 (6%)
Query: 986 PTDKEEEDEEEEFGDFRLVSNDNEFDSDEDEHSDSGNDLALEDHEDDDEEELLKRSEKLK 1045
P ++EE +EEEE + + E + +EDE + + ED E++++E EK++
Sbjct: 117 PVEEEEVEEEEE----EVEEEEKEEEKEEDEEEEEKEEEKEEDEEEEEKEGKKMEEEKVE 172
Query: 1046 RQM 1048
++
Sbjct: 173 EEI 175
Score = 30.8 bits (68), Expect = 9.1
Identities = 21/85 (24%), Positives = 41/85 (48%), Gaps = 11/85 (12%)
Query: 1016 EHSDSGNDLALEDHEDDDEEELLKRSEKLKRQMRLRKYLEDEAEVSGSDVGSEDEYDGEE 1075
E + L +E+ E ++EEE ++ EK E+E E + E+E + +E
Sbjct: 108 EECSAQQGLPVEEEEVEEEEEEVEEEEK-----------EEEKEEDEEEEEKEEEKEEDE 156
Query: 1076 IDEYEEDVIDEVLPSDEELQSQIKK 1100
+E +E E +EE+ ++I++
Sbjct: 157 EEEEKEGKKMEEEKVEEEIDTEIQR 181
>gi|225637560 NIMA-related kinase 11 isoform 1 [Homo sapiens]
Length = 645
Score = 61.2 bits (147), Expect = 6e-09
Identities = 78/370 (21%), Positives = 152/370 (41%), Gaps = 49/370 (13%)
Query: 526 RELEALKQRFWKHANPAAKPRAGQTVNVNVIVKDMGTDGKEELKADVVPVTLAPKKLD-- 583
+EL A+ + + NP+ +P A + + + + + + + L +TL K LD
Sbjct: 258 KELNAIMESML-NKNPSLRPSAIEILKIPYLDEQL-----QNLMCRYSEMTLEDKNLDCQ 311
Query: 584 -GASHTKPGEK----LQVLKAKLQ-------EAMKLRRFEERQKRQALFKLDNEDGFEEE 631
A+H + LQ L+A + E M+LR+ + ++ K E+ +EE
Sbjct: 312 KEAAHIINAMQKRIHLQTLRALSEVQKMTPRERMRLRKLQAADEKARKLKKIVEEKYEEN 371
Query: 632 EEEEEEMTDESEEDGEEKV--EK------EEKEEELE---------EEEEKEEEEEEEGN 674
+ +E+ + + V EK EEKEE+ E E+EE+ + EEE +
Sbjct: 372 SKRMQELRSRNFQQLSVDVLHEKTHLKGMEEKEEQPEGRLSCSPQDEDEERWQGREEESD 431
Query: 675 QETAEFLLSSEEIETKDEKEMDKENNDGSSEIGKAVGFLSVPKSLSSDSTLLLFKDSSSK 734
+ T E L S+ I + D E++ D +S++ G+ +P + L+ + +
Sbjct: 432 EPTLENLPESQPIPSMDLHELESIVEDATSDL----GYHEIP-----EDPLVAEEYYADA 482
Query: 735 MGYFPTEEKSETDENSGKQPSKLDEDDSCSLLTKESSHNSSFELIGSTIPSYQPCNRQTG 794
+ E E +E + ++P K ++ + + +S E + + + C T
Sbjct: 483 FDSYCEESDEEEEEIALERPEKEIRNEGSQPAYRTNQQDSDIEALARCLENVLGC---TS 539
Query: 795 RGTSFFPTAGGFRSPSPGLFRASLVSSASKSSGKLSEPSLPIEDSQDLYNASPEPKTLFL 854
T T SP P +F + + + K + + L E +++YN +
Sbjct: 540 LDTKTITTMAEDMSPGPPIFNSVMARTKMKRMRESAMQKLGTEVFEEVYNYLKRARHQNA 599
Query: 855 GAGDFQFCLE 864
+ + CLE
Sbjct: 600 SEAEIRECLE 609
>gi|6715600 golgi autoantigen, golgin subfamily a, 4 [Homo sapiens]
Length = 2230
Score = 60.8 bits (146), Expect = 8e-09
Identities = 249/1340 (18%), Positives = 507/1340 (37%), Gaps = 207/1340 (15%)
Query: 19 ISQEEADSPSDSGQGSYETIGPLSEGD-SDEEIFVSKKLKNR--------KVLQDSDSET 69
+ QE D S + + L E + + +E ++KKL+ R KV + S++
Sbjct: 462 VKQEVVDVMKKSSEEQIAKLQKLHEKELARKEQELTKKLQTREREFQEQMKVALEK-SQS 520
Query: 70 EDTNASPEKTTYDSAEEENKENLYAGKNTKIKRIYKTVADSDESYMEKSLYQENLEAQVK 129
E S EK +S E E T+ + + + E+Y + L +++
Sbjct: 521 EYLKISQEKEQQESLALEELELQKKAILTESENKLRDLQQEAETYRTRIL-------ELE 573
Query: 130 PCLELSLQSG-NSTDFTTDRKSSKKHIHDKEGTAGKAKVKSKRRLEKEERKM---EKIRQ 185
LE SLQ N + ++K+ H+KE T K K++ K ++ EK++
Sbjct: 574 SSLEKSLQENKNQSKDLAVHLEAEKNKHNKEITVMVEKHKTELESLKHQQDALWTEKLQV 633
Query: 186 LKKKETKNQEDDVEQPFNDSGCLLVDKDL-FETGLEDENNSPLED----EESLESIRAAV 240
LK++ E E+ + LL DK++ F+ +E+ N LE + LES+ + +
Sbjct: 634 LKQQYQTEMEKLREKCEQEKETLLKDKEIIFQAHIEEMNEKTLEKLDVKQTELESLSSEL 693
Query: 241 KNKVK-KHK-------------KKEPSLESGVHSFEEGSELSKGTTRKERKAA-RLSKEA 285
+K +HK K + LE+ + + + + KE + + + +++A
Sbjct: 694 SEVLKARHKLEEELSVLKDQTDKMKQELEAKMDEQKNHHQQQVDSIIKEHEVSIQRTEKA 753
Query: 286 LKQLHSETQRLIRESALNLPYHMPENKTIHDFFKRKPRPTCHGNAMALLKSSKYQSSHHK 345
LK ++ + L++E +L H + + KR +A + S YQS+ H
Sbjct: 754 LKDQINQLELLLKERDKHLKEHQAHVENLEADIKRSEGELQQASAKLDVFQS-YQSATH- 811
Query: 346 EIIDTANTTEMNSDHHSKGSEQTTGAENEVETNALPVVSKETQIITGSDESCRKDLVKNE 405
EQT E ++ ++ ET+ I + + + K +
Sbjct: 812 --------------------EQTKAYEEQLAQLQQKLLDLETERILLTKQVAEVEAQKKD 851
Query: 406 ---ELEIQEKQKQSDIRPSPGDSSVLQQESNFLGNNHSEECQVGGLVAFEPHALEGEGPQ 462
EL+ + Q Q ++ +S ++Q+ L + + + +G +
Sbjct: 852 VCTELDAHKIQVQDLMQQLEKQNSEMEQKVKSLTQVYESKLE--------------DGNK 897
Query: 463 NPEETDEKVEEPEQQNKSSAVGPPEKVRRFTLDRLKQLGVDVSIKPRLGADEDSFVILEP 522
E+T + + E E G +++ T +L A EDS IL
Sbjct: 898 EQEQTKQILVEKENMILQMREGQKKEIEILT--------------QKLSAKEDSIHILNE 943
Query: 523 ETNREL------------------EALKQRFWKHANPAAKPRAGQTVNVNVIVKDMGTDG 564
E + E LK++ K + ++ K
Sbjct: 944 EYETKFKNQEKKMEKVKQKAKEMQETLKKKLLDQEAKLKKELENTALELSQKEKQFNAKM 1003
Query: 565 KEELKADVVPVTLAPKKLDGASHTKPGEKLQVLKAKLQEAMKLRRFEERQKRQALFKLDN 624
E +A+ ++ A +L+ + +V + +L + + + + Q+ + L ++
Sbjct: 1004 LEMAQANSAGISDAVSRLETNQKEQIESLTEVHRRELNDVISIWEKKLNQQAEELQEIHE 1063
Query: 625 EDGFEEEEE-------------EEEEMTDESEEDGEEKVEKEEKEEELEEEEEKEEEEEE 671
E+E+E E+EEM E EE V+++ EL+E+ +++
Sbjct: 1064 IQLQEKEQEVAELKQKILLFGCEKEEMNKEITWLKEEGVKQDTTLNELQEQLKQKSAHVN 1123
Query: 672 EGNQETAEFLLSSEEIETKDEKEMDKENNDGSSEIGKAVGFLSVPKSLSSDSTLLLFKDS 731
Q+ + E++E K + KEN ++ + K S+ T L
Sbjct: 1124 SLAQDETKLKAHLEKLEVDLNKSL-KENTFLQEQLVELKMLAEEDKRKVSELTSKLKTTD 1182
Query: 732 SSKMGYFPTEEKSETD-ENSGKQPSKLDED-----DSCSLLTKESSHNSSFELIGSTIPS 785
+ EKS E+ + KL E+ D C T+ + ELI
Sbjct: 1183 EEFQSLKSSHEKSNKSLEDKSLEFKKLSEELAIQLDICCKKTEALLEAKTNELI------ 1236
Query: 786 YQPCNRQTGRGTSFFPTAGGFRSPSPGLFRASLVSSASKSSGKLSEPSLPIEDSQDLYNA 845
N + + + + + + A L+ + + S +L + + Q+ N
Sbjct: 1237 ----NISSSKTNAILSRISHCQHRTTKVKEALLIKTCTVS--ELEAQLRQLTEEQNTLNI 1290
Query: 846 SPEPKTLFLGAGDFQF-CLEDDTQSQLLDADGFLNVRNHRNQYQALKPRLPLASMDENAM 904
S + T L + Q ++ D +S + + + + NQ QA + + + +
Sbjct: 1291 SFQQATHQLEEKENQIKSMKADIESLVTEKEAL--QKEGGNQQQAASEKESCITQLKKEL 1348
Query: 905 DANMDELLDLCTGKFTSQAEKHLPRKSDKKENMEEL--LNLCSGKFTSQDASTPASSELN 962
N++ + T E+ +K + ++L LN+ S A S L
Sbjct: 1349 SENINAV--------TLMKEELKEKKVEISSLSKQLTDLNVQLQNSISLSEKEAAISSLR 1400
Query: 963 KQ--EKESSMGDPMEEALALCSGSFPTD---KEEEDEEEEFGDF--RLVSNDNEFDSDED 1015
KQ E++ + D +++ SF D KE+ E+ D+ + + S
Sbjct: 1401 KQYDEEKCELLDQVQDL------SFKVDTLSKEKISALEQVDDWSNKFSEWKKKAQSRFT 1454
Query: 1016 EHSDSGNDLAL-------EDHEDDDEEELLKR--SEKLKRQMRLRKYLEDE---AEVSGS 1063
+H ++ +L + E +E D++ LLK ++ KR L+ +ED+ E S
Sbjct: 1455 QHQNTVKELQIQLELKSKEAYEKDEQINLLKEELDQQNKRFDCLKGEMEDDKSKMEKKES 1514
Query: 1064 DVGSEDEYDGEEIDEYEEDV---------IDEVLPS-----DEELQSQIKKI-HMKTMLD 1108
++ +E + I E E+ + ++EVL + D E + ++K+ H + + +
Sbjct: 1515 NLETELKSQTARIMELEDHITQKTIEIESLNEVLKNYNQQKDIEHKELVQKLQHFQELGE 1574
Query: 1109 DDKRQLRLYQERYLADGDLHSDGPGRMRKFRWKNIDDASQMDLFHRDSDDDQTEEQLDES 1168
+ +++ +E+ L + + + K + + +L H + EE+L
Sbjct: 1575 EKDNRVKEAEEKILTLEN---------QVYSMKAELETKKKELEHVNLSVKSKEEELKAL 1625
Query: 1169 EARWRKERIEREQWLRDMAQQGKITAEEEEEIGEDSQFMILAKKVTAKALQKNASRPMVI 1228
E R E + L+ A+Q KI A +++ + + + KK T L + ++
Sbjct: 1626 EDRLESESAAKLAELKRKAEQ-KIAAIKKQLLSQMEEKEEQYKKGTESHLSELNTKLQER 1684
Query: 1229 QESKSLLRNPFEAIRPGSAQ 1248
+ +L +++ ++
Sbjct: 1685 EREVHILEEKLKSVESSQSE 1704
Score = 59.3 bits (142), Expect = 2e-08
Identities = 140/747 (18%), Positives = 297/747 (39%), Gaps = 106/747 (14%)
Query: 59 RKVLQDSDSETEDTNASPEKTTYDSAEEENKENLYAGKNTKIKRIYKTVADSDESYMEKS 118
R ++ ++ E+ EK+ + EE K A K + +R K D +EK+
Sbjct: 388 RSRIKQMTTQGEELREQKEKSERAAFEELEKALSTAQKTEEARRKLKAEMDEQIKTIEKT 447
Query: 119 LYQENLEAQVKPCLELSLQSGNSTDFTTDRKSSKKHI------HDKEGTAGKAKVKSKRR 172
+E + Q ELS D +KSS++ I H+KE + + + ++
Sbjct: 448 SEEERISLQ----QELSRVKQEVVDVM--KKSSEEQIAKLQKLHEKE--LARKEQELTKK 499
Query: 173 LEKEERKMEKIRQLKKKETKNQEDDVEQPFNDSGCLLVDK-DLFETGLEDENNSPLED-E 230
L+ ER+ ++ ++ ++++++ + Q L +++ +L + + E+ + L D +
Sbjct: 500 LQTREREFQEQMKVALEKSQSEYLKISQEKEQQESLALEELELQKKAILTESENKLRDLQ 559
Query: 231 ESLESIRAAV---KNKVKK--HKKKEPSLESGVHSFEEGSELSKGTT------RKERKAA 279
+ E+ R + ++ ++K + K S + VH E ++ +K T + E ++
Sbjct: 560 QEAETYRTRILELESSLEKSLQENKNQSKDLAVHLEAEKNKHNKEITVMVEKHKTELESL 619
Query: 280 RLSKEAL--------------------KQLHSETQRLIRESALNLPYHMPE--NKTIHDF 317
+ ++AL ++ E + L+++ + H+ E KT+
Sbjct: 620 KHQQDALWTEKLQVLKQQYQTEMEKLREKCEQEKETLLKDKEIIFQAHIEEMNEKTLEKL 679
Query: 318 FKRKPRPTCHGNAMALLKSSKYQSSHHKEIIDTANTTEMNSDHHSKGSEQTTGAENEVET 377
++ + ++ + ++++ ++ T +M + +K EQ + +V++
Sbjct: 680 DVKQTELESLSSELSEVLKARHKLEEELSVLKD-QTDKMKQELEAKMDEQKNHHQQQVDS 738
Query: 378 NALPVVSKETQIITGSDESCRKDLVKNEELEIQEKQK------------QSDIRPSPGDS 425
+ KE ++ E KD + EL ++E+ K ++DI+ S G+
Sbjct: 739 -----IIKEHEVSIQRTEKALKDQINQLELLLKERDKHLKEHQAHVENLEADIKRSEGE- 792
Query: 426 SVLQQESNFLGNNHSEECQVGGLV-AFEPHALEGEGPQNPEETD-----EKVEEPEQQNK 479
LQQ S L S + A+E + + ET+ ++V E E Q K
Sbjct: 793 --LQQASAKLDVFQSYQSATHEQTKAYEEQLAQLQQKLLDLETERILLTKQVAEVEAQKK 850
Query: 480 SSAVG-PPEKVRRFTLDRLKQLGVDVS-IKPRLGADEDSFVILEPETNRELEALKQRFWK 537
K++ D ++QL S ++ ++ + + + N+E E KQ +
Sbjct: 851 DVCTELDAHKIQ--VQDLMQQLEKQNSEMEQKVKSLTQVYESKLEDGNKEQEQTKQILVE 908
Query: 538 HANPAAKPRAGQTVNVNVIVKDMGTDGKEELKADVVPVTLAPKKLDGASHTKPGEKLQVL 597
N + R GQ + ++ + K K D + + + + K EK++
Sbjct: 909 KENMILQMREGQKKEIEILTQ------KLSAKEDSIHILNEEYETKFKNQEKKMEKVKQK 962
Query: 598 KAKLQEAMKLRRFEERQK------RQALFKLDNEDGFEEEEEEEEEMTDESEEDGEEKVE 651
++QE +K + ++ K AL E F + E + D ++E
Sbjct: 963 AKEMQETLKKKLLDQEAKLKKELENTALELSQKEKQFNAKMLEMAQANSAGISDAVSRLE 1022
Query: 652 KEEKEE-----ELEEEE--------EKEEEEEEEGNQETAEFLLSSEEIETKDEKEMDKE 698
+KE+ E+ E EK+ ++ E QE E L +E E + K+
Sbjct: 1023 TNQKEQIESLTEVHRRELNDVISIWEKKLNQQAEELQEIHEIQLQEKEQEVAELKQKILL 1082
Query: 699 NNDGSSEIGKAVGFLSVPKSLSSDSTL 725
E+ K + +L + + D+TL
Sbjct: 1083 FGCEKEEMNKEITWLK-EEGVKQDTTL 1108
Score = 52.8 bits (125), Expect = 2e-06
Identities = 130/737 (17%), Positives = 297/737 (40%), Gaps = 86/737 (11%)
Query: 34 SYETIGPLSEGDSDEEIFVSKKLKNRKVLQDSDSETEDTNASPEKTTYDSAEEENKENLY 93
S E I L + D F K K + + ++ E + ++ E++ + NL
Sbjct: 1425 SKEKISALEQVDDWSNKFSEWKKKAQSRFTQHQNTVKELQIQLELKSKEAYEKDEQINLL 1484
Query: 94 AGKNTKIKRIY---KTVADSDESYMEKSLYQENLEAQVKPCLELSLQSGNSTDFTTDRKS 150
+ + + + K + D+S MEK + NLE ++K ++ D T +
Sbjct: 1485 KEELDQQNKRFDCLKGEMEDDKSKMEKK--ESNLETELKSQTARIMEL---EDHITQKTI 1539
Query: 151 SKKHIHDKEGTAGKAKVKSKRRLEKEERKMEKIRQLKKKETKNQEDDVEQPFNDSGCLLV 210
+ +++ + K + L ++ + +++ + K K E+ + L +
Sbjct: 1540 EIESLNEVLKNYNQQKDIEHKELVQKLQHFQELGEEKDNRVKEAEEKI---------LTL 1590
Query: 211 DKDLFETGLEDENNSPLEDEESLESIRAAVKNKVKKHKKKEPSLESGVHSFEEGSELSKG 270
+ ++ E E ++ LE + +VK+K ++ K E LES E ++L++
Sbjct: 1591 ENQVYSMKAELETK-----KKELEHVNLSVKSKEEELKALEDRLES-----ESAAKLAEL 1640
Query: 271 TTRKERKAARLSKEALKQLHSETQRLIRE-----SALNLPYHMPENKTIHDFFKRKPRPT 325
+ E+K A + K+ L Q+ + ++ + S LN E + K K +
Sbjct: 1641 KRKAEQKIAAIKKQLLSQMEEKEEQYKKGTESHLSELNTKLQEREREVHILEEKLKSVES 1700
Query: 326 CHGNAMALLKSSKYQSSH-HKEIIDTANTTEMNSDHHSKGSEQTTGAENEVETNALPVVS 384
+ + +S+K +++ +E D+ + + ++ + ++ L V
Sbjct: 1701 SQSETLIVPRSAKNVAAYTEQEEADSQGCVQKTYEEKISVLQRNLTEKEKL----LQRVG 1756
Query: 385 KETQIITGSDESCR----KDLVKNEELEIQEKQKQSDIRPSPGDSSVLQQESNFLGNNHS 440
+E + S R + L+K E E ++ + QS I + ++ + + H
Sbjct: 1757 QEKEETVSSHFEMRCQYQERLIKLEHAEAKQHEDQSMIGHLQEELEEKNKKYSLIVAQHV 1816
Query: 441 EECQVGGLVAFEPHALEGEGPQNPEETDEKVEEPEQQNKSSAVGPPEKVRRFTLDRLKQL 500
E+ E + QN E + V++ Q+ + + +K++ ++Q
Sbjct: 1817 EK---------EGGKNNIQAKQNLENVFDDVQKTLQEKELTCQILEQKIKELDSCLVRQK 1867
Query: 501 GVDVSIKPRLGADEDSFVILEPET--NRELEALKQRFW-KHANPAAKPRAGQTVNV---N 554
V L + + L+ N+ E L++ K + +P+ + +
Sbjct: 1868 EVHRVEMEELTSKYEKLQALQQMDGRNKPTELLEENTEEKSKSHLVQPKLLSNMEAQHND 1927
Query: 555 VIVKDMGTDG-KEELKADVV---------------PVTLAPKKLDGASHTKPGEKLQVLK 598
+ K G + K++L ++V + + K+ D K ++ + L+
Sbjct: 1928 LEFKLAGAEREKQKLGKEIVRLQKDLRMLRKEHQQELEILKKEYDQEREEKIKQEQEDLE 1987
Query: 599 AKLQEAMK--LRRFEER--QKRQALFKLDNEDGFEEEEEEEEEMTDESEEDGEEKVEK-E 653
K +K +R F + QK Q L ++ ++ + +E E E+ + +E+ + ++K
Sbjct: 1988 LKHNSTLKQLMREFNTQLAQKEQEL-EMTIKETINKAQEVEAELLESHQEETNQLLKKIA 2046
Query: 654 EKEEELEEEEEKEEE----EEEEGNQETAEFLLSSEEIETKDEKEMDKENNDGSSEIGKA 709
EK+++L+ ++ EE EEE + + EE++ K ++++++E N G+
Sbjct: 2047 EKDDDLKRTAKRYEEILDAREEEMTAKVRDLQTQLEELQKKYQQKLEQEENPGNDN---- 2102
Query: 710 VGFLSVPKSLSSDSTLL 726
V + + L+ +TL+
Sbjct: 2103 VTIMELQTQLAQKTTLI 2119
Score = 36.6 bits (83), Expect = 0.17
Identities = 68/345 (19%), Positives = 141/345 (40%), Gaps = 34/345 (9%)
Query: 909 DELLDLCTGKFTSQAEKHLPRKSDKKENMEELLNLCSGKFTSQDASTPASSELNKQEKES 968
+ LL C S E+ S+K+ E+L +D ++L Q +++
Sbjct: 292 ENLLKRCKETIQSHKEQCTLLTSEKEALQEQLDERLQELEKIKDLHMAEKTKLITQLRDA 351
Query: 969 -SMGDPMEEALALCSGSFPTDKEE--EDEEEEFGDFRLVSNDNEFDSDE-DEHSDSGNDL 1024
++ + +E+ + E E +EEE R +E E +
Sbjct: 352 KNLIEQLEQDKGMVIAETKRQMHETLEMKEEEIAQLRSRIKQMTTQGEELREQKEKSERA 411
Query: 1025 ALEDHEDDDEEELLKRSEKLKRQMRLRKYLEDEAEVSGSDVGSEDEYDG--EEIDEYEED 1082
A E+ E + L ++K + R K DE ++ + SE+E +E+ +++
Sbjct: 412 AFEELE-----KALSTAQKTEEARRKLKAEMDE-QIKTIEKTSEEERISLQQELSRVKQE 465
Query: 1083 VIDEVLPSDEELQSQIKKIHMKTMLDDDKRQLRLYQERYLADGDLHSDGPGRMRKFRWKN 1142
V+D + S EE ++++K+H K + ++ + Q R R + + K
Sbjct: 466 VVDVMKKSSEEQIAKLQKLHEKELARKEQELTKKLQTR------------EREFQEQMKV 513
Query: 1143 IDDASQMDLFHRDSDDDQTEE-QLDESEARWRKERIEREQWLRDMAQQG--------KIT 1193
+ SQ + + +Q E L+E E + + E E LRD+ Q+ ++
Sbjct: 514 ALEKSQSEYLKISQEKEQQESLALEELELQKKAILTESENKLRDLQQEAETYRTRILELE 573
Query: 1194 AEEEEEIGED-SQFMILAKKVTAKALQKNASRPMVIQESKSLLRN 1237
+ E+ + E+ +Q LA + A+ + N +++++ K+ L +
Sbjct: 574 SSLEKSLQENKNQSKDLAVHLEAEKNKHNKEITVMVEKHKTELES 618
Score = 34.7 bits (78), Expect = 0.63
Identities = 91/459 (19%), Positives = 178/459 (38%), Gaps = 48/459 (10%)
Query: 333 LLKSSKYQSSHHKEIIDTANTTEMNSDHHSKGSEQTTGAENEVETNALPVVSKETQIITG 392
LLK K HKE T + S+ + EQ E+E ++++T++IT
Sbjct: 294 LLKRCKETIQSHKE-----QCTLLTSEKEAL-QEQLDERLQELEKIKDLHMAEKTKLITQ 347
Query: 393 SDESCR--KDLVKNEELEIQEKQKQSDIRPSPGDSSVLQQESNFL-----GNNHSEECQV 445
++ + L +++ + I E ++Q + + Q S G E+ +
Sbjct: 348 LRDAKNLIEQLEQDKGMVIAETKRQMHETLEMKEEEIAQLRSRIKQMTTQGEELREQKEK 407
Query: 446 GGLVAFEPHALEGEGPQNPEETDEKV--EEPEQQNKSSAVGPPEKVR-RFTLDRLKQLGV 502
AFE Q EE K+ E EQ E++ + L R+KQ V
Sbjct: 408 SERAAFEELEKALSTAQKTEEARRKLKAEMDEQIKTIEKTSEEERISLQQELSRVKQEVV 467
Query: 503 DV-------SIKPRLGADEDSFVILEPETNRELEALKQRFWKHANPAAKPRAGQTVNVNV 555
DV I E E E ++L+ ++ F + A + + + ++
Sbjct: 468 DVMKKSSEEQIAKLQKLHEKELARKEQELTKKLQTREREFQEQMKVALEKSQSEYLKISQ 527
Query: 556 IVKDMGTDGKEELKADVVPV-TLAPKKLDGASHTKPGEKLQVLKAKLQEAMKLRRFEERQ 614
+ + EEL+ + T + KL + ++L+ + L+ + +
Sbjct: 528 EKEQQESLALEELELQKKAILTESENKLRDLQQEAETYRTRILELESSLEKSLQENKNQS 587
Query: 615 KRQALFKLDNEDG---------FEEEEEEEEEMTDESEEDGEEKVEKEEKEEELEEEEEK 665
K A+ L+ E E+ + E E + + + EK++ +++ + E E+ +
Sbjct: 588 KDLAVH-LEAEKNKHNKEITVMVEKHKTELESLKHQQDALWTEKLQVLKQQYQTEMEKLR 646
Query: 666 EEEEEEEGNQETAEFLLSSEEIETKDEKEMDK------ENNDGSSEIGKAVGFLSVPKSL 719
E+ E+E+ + ++ IE +EK ++K E SSE+ + L L
Sbjct: 647 EKCEQEKETLLKDKEIIFQAHIEEMNEKTLEKLDVKQTELESLSSELSEV---LKARHKL 703
Query: 720 SSDSTLLLFKDSSSKMGYFPTEEKSETDENSGKQPSKLD 758
+ ++L KD + KM E +++ DE ++D
Sbjct: 704 EEELSVL--KDQTDKM---KQELEAKMDEQKNHHQQQVD 737
Score = 32.7 bits (73), Expect = 2.4
Identities = 67/324 (20%), Positives = 126/324 (38%), Gaps = 33/324 (10%)
Query: 394 DESCRKDLVKNEELEIQEKQKQSDIRPSPGDSSVLQQESNFLGNNHSEECQVGGLVAFEP 453
D+ +K L + + ++EK + + + S+L+Q L N + L EP
Sbjct: 199 DQQAKKHLQEEFDASLEEKDQYISVLQT--QVSLLKQR---LRNGPMNVDVLKPLPQLEP 253
Query: 454 HALEGEGPQNPEETDEKVEEPEQQNKSSAVGPPEKVRRFTLDRLK-QLGVDVSIKPRLGA 512
A +NPE E V E G K R+K Q + K + +
Sbjct: 254 QAEVFTKEENPESDGEPVVED---------GTSVKTLETLQQRVKRQENLLKRCKETIQS 304
Query: 513 DEDSFVILEPETNRELEALKQRFWKHANPAAKPRAGQTVNVNVIVKDMGTDGK---EELK 569
++ +L E E L +R + A +T + + D K E+L+
Sbjct: 305 HKEQCTLLTSEKEALQEQLDERLQELEKIKDLHMAEKTKLITQL-----RDAKNLIEQLE 359
Query: 570 ADVVPVTLAPKKLDGASHTKPGEKLQVLKAKLQEAM----KLRRFEERQKRQALFKLDNE 625
D V K+ + E++ L++++++ +LR +E+ +R A +L+
Sbjct: 360 QDKGMVIAETKRQMHETLEMKEEEIAQLRSRIKQMTTQGEELREQKEKSERAAFEELEKA 419
Query: 626 DGFEEEEEEEEEMTDESEEDGEEKVEKEEKEEELEEEEEKEEEEEEEGNQETAEFL-LSS 684
++ EE ++ + +EK +EE + ++E + QE + + SS
Sbjct: 420 LSTAQKTEEARRKLKAEMDEQIKTIEKTSEEERISLQQELSRVK-----QEVVDVMKKSS 474
Query: 685 EEIETKDEKEMDKENNDGSSEIGK 708
EE K +K +KE E+ K
Sbjct: 475 EEQIAKLQKLHEKELARKEQELTK 498
>gi|13569879 acidic (leucine-rich) nuclear phosphoprotein 32 family,
member E isoform 1 [Homo sapiens]
Length = 268
Score = 60.8 bits (146), Expect = 8e-09
Identities = 55/208 (26%), Positives = 102/208 (49%), Gaps = 29/208 (13%)
Query: 523 ETNRELEALKQRFWKHANPAAKPRAGQTVNVNVIVKDMGTDGKEELKADVVP----VTLA 578
+T +ELE L + ++ A P + + + D G E+ A+ P + L+
Sbjct: 39 DTFKELEFLSMANVELSSLARLPSLNKLRKLEL--SDNIISGGLEVLAEKCPNLTYLNLS 96
Query: 579 PKKLDGASHTKPGEKLQVLKAKLQEAMKLRRFEERQKRQALFKLDNE----DGFEEEEEE 634
K+ S + + L+ LK+ ++ E+ R+++F+L + DGF++E+ E
Sbjct: 97 GNKIKDLSTVEALQNLKNLKSLDLFNCEITNLEDY--RESIFELLQQITYLDGFDQEDNE 154
Query: 635 EEEMTDESEEDGEEKVEKEEK---------EEELEEEEEKEEEEEEEGNQETAEFLLSSE 685
+ +E +EDG+E E+EE+ EEE EEEEE++E+E+E+ ++ +E E
Sbjct: 155 APDSEEEDDEDGDEDDEEEEENEAGPPEGYEEEEEEEEEEDEDEDEDEDEAGSELGEGEE 214
Query: 686 EI--------ETKDEKEMDKENNDGSSE 705
E+ E +DE++ D +G E
Sbjct: 215 EVGLSYLMKEEIQDEEDDDDYVEEGEEE 242
Score = 45.1 bits (105), Expect = 5e-04
Identities = 29/87 (33%), Positives = 48/87 (55%), Gaps = 14/87 (16%)
Query: 626 DGFEEEEEEEEEMTDESEED----GEEKVEKEEK-------EEELEEEEEKE---EEEEE 671
+G+EEEEEEEEE ++ +ED G E E EE+ +EE+++EE+ + EE EE
Sbjct: 182 EGYEEEEEEEEEEDEDEDEDEDEAGSELGEGEEEVGLSYLMKEEIQDEEDDDDYVEEGEE 241
Query: 672 EGNQETAEFLLSSEEIETKDEKEMDKE 698
E +E + + +D+ E + +
Sbjct: 242 EEEEEEGGLRGEKRKRDAEDDGEEEDD 268
Score = 45.1 bits (105), Expect = 5e-04
Identities = 34/87 (39%), Positives = 46/87 (52%), Gaps = 16/87 (18%)
Query: 630 EEEEEEEEMTDESEEDGEEKVEKE--EKEEE-----LEEEEEKEEEEE----EEGNQETA 678
EEEEEEEE DE E++ E++ E E EEE L +EE ++EE++ EEG +E
Sbjct: 185 EEEEEEEEEEDEDEDEDEDEAGSELGEGEEEVGLSYLMKEEIQDEEDDDDYVEEGEEEEE 244
Query: 679 EFLLSSEEIETKDEKEMDKENNDGSSE 705
E EE + EK +DG E
Sbjct: 245 E-----EEGGLRGEKRKRDAEDDGEEE 266
Score = 40.0 bits (92), Expect = 0.015
Identities = 22/59 (37%), Positives = 38/59 (64%), Gaps = 8/59 (13%)
Query: 623 DNEDGFEEEEEEEE---EMTDESEEDG-----EEKVEKEEKEEELEEEEEKEEEEEEEG 673
+ E+ +E+E+E+E E+ + EE G +E+++ EE +++ EE E+EEEEEE G
Sbjct: 191 EEEEDEDEDEDEDEAGSELGEGEEEVGLSYLMKEEIQDEEDDDDYVEEGEEEEEEEEGG 249
Score = 37.0 bits (84), Expect = 0.13
Identities = 38/154 (24%), Positives = 67/154 (43%), Gaps = 40/154 (25%)
Query: 932 DKKENMEELLNLCS--GKFTSQDASTPASSELNKQEKESSMGDPMEEALALCSGSFPTDK 989
D +E++ ELL + F +D P S +E++ GD +
Sbjct: 130 DYRESIFELLQQITYLDGFDQEDNEAPDS-----EEEDDEDGD---------------ED 169
Query: 990 EEEDEEEEFGDFRLVSNDNEFDSDEDEHSDSGNDLALEDHEDDDEEELLKRSEKLKRQMR 1049
+EE+EE E G + E + +EDE D + ED+ EL + E++
Sbjct: 170 DEEEEENEAGPPEGYEEEEEEEEEEDEDED--------EDEDEAGSELGEGEEEVGLSYL 221
Query: 1050 LRKYLEDEAEVSGSDVGSEDEY--DGEEIDEYEE 1081
+++ ++DE + +D+Y +GEE +E EE
Sbjct: 222 MKEEIQDEED--------DDDYVEEGEEEEEEEE 247
Score = 35.0 bits (79), Expect = 0.48
Identities = 35/134 (26%), Positives = 64/134 (47%), Gaps = 14/134 (10%)
Query: 991 EEDEEEEFGDFRLVSNDNEFDSDEDEHSDSGNDLALEDHEDDDEEELLKRS-----EKLK 1045
E+ E F + ++ + FD +++E DS + + EDD+EEE + E+ +
Sbjct: 129 EDYRESIFELLQQITYLDGFDQEDNEAPDSEEEDDEDGDEDDEEEEENEAGPPEGYEEEE 188
Query: 1046 RQMRLRKYLEDEAE-VSGSDVGSEDEYDG------EEI--DEYEEDVIDEVLPSDEELQS 1096
+ EDE E +GS++G +E G EEI +E ++D ++E +EE +
Sbjct: 189 EEEEEEDEDEDEDEDEAGSELGEGEEEVGLSYLMKEEIQDEEDDDDYVEEGEEEEEEEEG 248
Query: 1097 QIKKIHMKTMLDDD 1110
++ K +DD
Sbjct: 249 GLRGEKRKRDAEDD 262
Score = 31.2 bits (69), Expect = 7.0
Identities = 17/56 (30%), Positives = 31/56 (55%)
Query: 611 EERQKRQALFKLDNEDGFEEEEEEEEEMTDESEEDGEEKVEKEEKEEELEEEEEKE 666
EE L K + +D ++++ EE +E EE+G + EK +++ E + EEE +
Sbjct: 213 EEEVGLSYLMKEEIQDEEDDDDYVEEGEEEEEEEEGGLRGEKRKRDAEDDGEEEDD 268
Score = 30.8 bits (68), Expect = 9.1
Identities = 11/31 (35%), Positives = 19/31 (61%)
Query: 457 EGEGPQNPEETDEKVEEPEQQNKSSAVGPPE 487
+ E P + EE DE +E +++ + + GPPE
Sbjct: 152 DNEAPDSEEEDDEDGDEDDEEEEENEAGPPE 182
>gi|38044112 restin isoform b [Homo sapiens]
Length = 1392
Score = 60.5 bits (145), Expect = 1e-08
Identities = 165/841 (19%), Positives = 334/841 (39%), Gaps = 108/841 (12%)
Query: 23 EADSPSDSGQGSYETIGPLSEGDSDEEIFVSKKLKNRKVLQDSDSETEDTNASPEKTTYD 82
E++ P+ S + +S E+ + + L++ E+T+ K Y
Sbjct: 488 ESNKPAGDVDMSLSLLQEISSLQEKLEVTRTDHQREITSLKEHFGAREETHQKEIKALYT 547
Query: 83 SAEEENKEN-------LYAGK-NTKIKRIYK----TVADSDESYME-------KSLYQEN 123
+ E+ +KEN +A K N+ + ++K T S + ME K L E
Sbjct: 548 ATEKLSKENESLKSKLEHANKENSDVIALWKSKLETAIASHQQAMEELKVSFSKGLGTET 607
Query: 124 LE-AQVKPCLE-LSLQSGNSTDFTTDRKSSKKHIHDKEGTAGKAKV-----KSKRRLEKE 176
E A++K +E + L + + +++ S++ H KE A +AK+ + + LE
Sbjct: 608 AEFAELKTQIEKMRLDYQHEIENLQNQQDSERAAHAKEMEALRAKLMKVIKEKENSLEAI 667
Query: 177 ERKMEK------------IRQLKKKETKNQEDDVEQPFNDSGCLLVDKDLFETGLEDENN 224
K++K + +L++ E K +E +V Q + ++D + +E
Sbjct: 668 RSKLDKAEDQHLVEMEDTLNKLQEAEIKVKELEVLQAKCNEQTKVIDNFTSQLKATEEK- 726
Query: 225 SPLEDEESLESIRAAVKNKVKKHKKKEPSLESGVH--SFEEGSELSKGTT-RKERKAARL 281
L D ++L + K+++KK +++ + E + E+ +E SK ++ +E + L
Sbjct: 727 --LLDLDALRKASSEGKSEMKKLRQQLEAAEKQIKHLEIEKNAESSKASSITRELQGREL 784
Query: 282 SKEALKQLHSETQRLIRESALNLPYHMPENKTIHDFFKRKPRPTCHGNAMALLKSSKYQS 341
L++ SE ++ + L + + K F + +M + +Q
Sbjct: 785 KLTNLQENLSEVSQV--KETLEKELQILKEK----FAEASEEAVSVQRSMQETVNKLHQK 838
Query: 342 SHHKEII--DTANTTEMNSDHHSKGSEQTTGAENEVETNALPVVSKETQIITGSDESCRK 399
++ D E +D +K E+ E ++ + + +I+ S ++ +
Sbjct: 839 EEQFNMLSSDLEKLRENLADMEAKFREKDEREEQLIKAKE-KLENDIAEIMKMSGDNSSQ 897
Query: 400 DLVKNEELEIQEK---QKQSDIRPSPGDSSVLQQESNFLGNNHSEECQVGGLVAFEPHAL 456
N+EL ++E+ + Q + + ++S LQ+ + +E+ Q E
Sbjct: 898 LTKMNDELRLKERDVEELQLKLTKANENASFLQKSIEDM-TVKAEQSQQEAAKKHEEEKK 956
Query: 457 EGEGPQNPEETDEKVEEPEQQ------NKSSAVGPPEKVRRFTLDRLKQLGVDVSIKPRL 510
E E + + ++K+E Q A + L L++ +D K +
Sbjct: 957 ELE--RKLSDLEKKMETSHNQCQELKARYERATSETKTKHEEILQNLQKTLLDTEDKLKG 1014
Query: 511 GADEDSFVILEPETNRELEALKQRFWKHANPAAKPRAGQTVNVNVIVKDMGTDGKEELKA 570
+E+S ++ +ELE L+++ A K +A QT + + + T K E A
Sbjct: 1015 AREENSGLL------QELEELRKQ-------ADKAKAAQTAEDAMQIMEQMTKEKTETLA 1061
Query: 571 DVVPVTLAPKKLDGASHTKPGEKL----------QVLKAKLQEAMKLRRFEERQKRQALF 620
+ KL T L ++L + Q+ + R+ E K+ A
Sbjct: 1062 SLEDTKQTNAKLQNELDTLKENNLKNVEELNKSKELLTVENQKMEEFRKEIETLKQAAAQ 1121
Query: 621 KLDNEDGFEEEEEE--EEEMTDESEEDGEEKVEKEEK--EEELEEEEEKEEEEEEEGNQE 676
K +EE + EE E +K+E+E +L E +++E + ++ ++E
Sbjct: 1122 KSQQLSALQEENVKLAEELGRSRDEVTSHQKLEEERSVLNNQLLEMKKRESKFIKDADEE 1181
Query: 677 TAEFLLS---SEEIETKDEKEMDKENNDGS---SEIGKAVGFLSVPKSLSSDSTLLLFKD 730
A S + + T+ + E++K N+ + E A SV ++L SD L K
Sbjct: 1182 KASLQKSISITSALLTEKDAELEKLRNEVTVLRGENASAKSLHSVVQTLESDKVKLELKV 1241
Query: 731 SSSKMGYFPTEEKSETDENSGKQPSKLDEDDSCSLLTKESSHNSSFELIGSTIPSYQPCN 790
+ ++ E K + +SG ++ DED E + S + + S I Q N
Sbjct: 1242 KNLELQL--KENKRQLSSSSGNTDTQADED--------ERAQESQIDFLNSVIVDLQRKN 1291
Query: 791 R 791
+
Sbjct: 1292 Q 1292
Score = 57.8 bits (138), Expect = 7e-08
Identities = 124/628 (19%), Positives = 249/628 (39%), Gaps = 89/628 (14%)
Query: 133 ELSLQSGNSTDFTTDRKSSKKHIHDKEGTAGKAKVKSKRRLEKEERKMEKIRQLKKKETK 192
EL+L + ++ + A + KV+ +LE+E+RK+E ++ ++E+
Sbjct: 391 ELALARDGHDQHVLELEAKMDQLRTMVEAADREKVELLNQLEEEKRKVEDLQFRVEEESI 450
Query: 193 NQED-DVEQPFNDSGCLLVDKDLFETGLEDENNSPLEDEESLESIRAAVKNKVKKHKKKE 251
+ D +V S + ++KDL L +E E R NK
Sbjct: 451 TKGDLEVATVSEKSRIMELEKDL-----------ALRVQEVAELRRRLESNKPAGDVDMS 499
Query: 252 PSLESGVHSFEEGSELSKG------TTRKERKAAR--LSKEALKQLHSETQRLIRESAL- 302
SL + S +E E+++ T+ KE AR ++ +K L++ T++L +E+
Sbjct: 500 LSLLQEISSLQEKLEVTRTDHQREITSLKEHFGAREETHQKEIKALYTATEKLSKENESL 559
Query: 303 --NLPYHMPENKTIHDFFKRKPRPTC--HGNAMALLKSS-----KYQSSHHKEIIDTANT 353
L + EN + +K K H AM LK S +++ E+
Sbjct: 560 KSKLEHANKENSDVIALWKSKLETAIASHQQAMEELKVSFSKGLGTETAEFAELKTQIEK 619
Query: 354 TEMNSDHHSKGSEQTTGAENEVETNALPVV-SKETQIITGSDESCRKDLVKNEELEIQEK 412
++ H + + +E + + +K ++I + S K ++ E Q
Sbjct: 620 MRLDYQHEIENLQNQQDSERAAHAKEMEALRAKLMKVIKEKENSLEAIRSKLDKAEDQHL 679
Query: 413 QKQSDIRPSPGDSSVLQQESNFLGNNHSEECQV-----GGLVAFEPHALE--------GE 459
+ D ++ + +E L +E+ +V L A E L+ E
Sbjct: 680 VEMEDTLNKLQEAEIKVKELEVLQAKCNEQTKVIDNFTSQLKATEEKLLDLDALRKASSE 739
Query: 460 GPQNPEETDEKVEEPEQQNKSSAVGPPEKVRRFTLDRLKQLGVDVSIKPRLGADEDSFVI 519
G ++ +++E E+Q K + + + + + G ++ + L +
Sbjct: 740 GKSEMKKLRQQLEAAEKQIKHLEIEKNAESSKASSITRELQGRELKLT-NLQENLSEVSQ 798
Query: 520 LEPETNRELEALKQRFWKHANPAAKPRAGQTVNVNVIVKDMGTDGKEE----LKADVVPV 575
++ +EL+ LK++F + + A + VN + + KEE L +D+ +
Sbjct: 799 VKETLEKELQILKEKFAEASEEAVSVQRSMQETVNKLHQ------KEEQFNMLSSDLEKL 852
Query: 576 TLAPKKLDGASHTKPGEKLQVLKAK------LQEAMKLRRFEERQKRQALFKLDNEDGFE 629
++ K + Q++KAK + E MK+ Q L K+++E +
Sbjct: 853 RENLADMEAKFREKDEREEQLIKAKEKLENDIAEIMKMSGDNSSQ----LTKMNDELRLK 908
Query: 630 EEEEEE-------------------EEMTDESEEDGEEKVEK-EEKEEELEEE----EEK 665
E + EE E+MT ++E+ +E +K EE+++ELE + E+K
Sbjct: 909 ERDVEELQLKLTKANENASFLQKSIEDMTVKAEQSQQEAAKKHEEEKKELERKLSDLEKK 968
Query: 666 EEEEEEEGNQETAEFLLSSEEIETKDEK 693
E + + A + ++ E +TK E+
Sbjct: 969 METSHNQCQELKARYERATSETKTKHEE 996
Score = 38.5 bits (88), Expect = 0.044
Identities = 73/376 (19%), Positives = 143/376 (38%), Gaps = 60/376 (15%)
Query: 867 TQSQLLDAD--------GFLNVRNHRNQYQALKPRLPLASMDENAMDANMDELLDLCTGK 918
T+ +LLD D G ++ R Q +A + ++ +++NA + + G+
Sbjct: 723 TEEKLLDLDALRKASSEGKSEMKKLRQQLEAAEKQIKHLEIEKNAESSKASSITRELQGR 782
Query: 919 FT--SQAEKHLPRKSDKKENMEELLNLCSGKFTSQDASTPASSELNKQEKESSMGDPMEE 976
+ +++L S KE +E+ L + KF + EE
Sbjct: 783 ELKLTNLQENLSEVSQVKETLEKELQILKEKFA----------------------EASEE 820
Query: 977 ALALCSGSFPTDKEEEDEEEEFGDFRLVSNDNEFDSDEDEHSDSGNDLALEDHEDDD-EE 1035
A+++ T + +EE+F N SD ++ ++ D+ + E D+ EE
Sbjct: 821 AVSVQRSMQETVNKLHQKEEQF---------NMLSSDLEKLRENLADMEAKFREKDEREE 871
Query: 1036 ELLKRSEKLKRQMRLRKYLEDEAEVSGSDVGSEDEYDGEEIDEYEEDVIDEVLPSDEELQ 1095
+L+K EKL+ + + ++SG D S+ +E+ E DV EELQ
Sbjct: 872 QLIKAKEKLEND------IAEIMKMSG-DNSSQLTKMNDELRLKERDV--------EELQ 916
Query: 1096 SQIKKIHMK-TMLDDDKRQLRLYQERYLADGDLHSDGPGRMRKFRWKNIDDASQMDLFHR 1154
++ K + + L + + E+ + + ++ K D +M+ H
Sbjct: 917 LKLTKANENASFLQKSIEDMTVKAEQ--SQQEAAKKHEEEKKELERKLSDLEKKMETSHN 974
Query: 1155 DSDDDQTEEQLDESEARWRKERIEREQWLRDMAQQGKITAEEEEEIGEDSQFMILAKKVT 1214
+ + + SE + + E I + + + K+ EE G + L K+
Sbjct: 975 QCQELKARYERATSETKTKHEEILQNLQKTLLDTEDKLKGAREENSGLLQELEELRKQAD 1034
Query: 1215 AKALQKNASRPMVIQE 1230
+ A M I E
Sbjct: 1035 KAKAAQTAEDAMQIME 1050
>gi|4506751 restin isoform a [Homo sapiens]
Length = 1427
Score = 60.5 bits (145), Expect = 1e-08
Identities = 165/841 (19%), Positives = 334/841 (39%), Gaps = 108/841 (12%)
Query: 23 EADSPSDSGQGSYETIGPLSEGDSDEEIFVSKKLKNRKVLQDSDSETEDTNASPEKTTYD 82
E++ P+ S + +S E+ + + L++ E+T+ K Y
Sbjct: 523 ESNKPAGDVDMSLSLLQEISSLQEKLEVTRTDHQREITSLKEHFGAREETHQKEIKALYT 582
Query: 83 SAEEENKEN-------LYAGK-NTKIKRIYK----TVADSDESYME-------KSLYQEN 123
+ E+ +KEN +A K N+ + ++K T S + ME K L E
Sbjct: 583 ATEKLSKENESLKSKLEHANKENSDVIALWKSKLETAIASHQQAMEELKVSFSKGLGTET 642
Query: 124 LE-AQVKPCLE-LSLQSGNSTDFTTDRKSSKKHIHDKEGTAGKAKV-----KSKRRLEKE 176
E A++K +E + L + + +++ S++ H KE A +AK+ + + LE
Sbjct: 643 AEFAELKTQIEKMRLDYQHEIENLQNQQDSERAAHAKEMEALRAKLMKVIKEKENSLEAI 702
Query: 177 ERKMEK------------IRQLKKKETKNQEDDVEQPFNDSGCLLVDKDLFETGLEDENN 224
K++K + +L++ E K +E +V Q + ++D + +E
Sbjct: 703 RSKLDKAEDQHLVEMEDTLNKLQEAEIKVKELEVLQAKCNEQTKVIDNFTSQLKATEEK- 761
Query: 225 SPLEDEESLESIRAAVKNKVKKHKKKEPSLESGVH--SFEEGSELSKGTT-RKERKAARL 281
L D ++L + K+++KK +++ + E + E+ +E SK ++ +E + L
Sbjct: 762 --LLDLDALRKASSEGKSEMKKLRQQLEAAEKQIKHLEIEKNAESSKASSITRELQGREL 819
Query: 282 SKEALKQLHSETQRLIRESALNLPYHMPENKTIHDFFKRKPRPTCHGNAMALLKSSKYQS 341
L++ SE ++ + L + + K F + +M + +Q
Sbjct: 820 KLTNLQENLSEVSQV--KETLEKELQILKEK----FAEASEEAVSVQRSMQETVNKLHQK 873
Query: 342 SHHKEII--DTANTTEMNSDHHSKGSEQTTGAENEVETNALPVVSKETQIITGSDESCRK 399
++ D E +D +K E+ E ++ + + +I+ S ++ +
Sbjct: 874 EEQFNMLSSDLEKLRENLADMEAKFREKDEREEQLIKAKE-KLENDIAEIMKMSGDNSSQ 932
Query: 400 DLVKNEELEIQEK---QKQSDIRPSPGDSSVLQQESNFLGNNHSEECQVGGLVAFEPHAL 456
N+EL ++E+ + Q + + ++S LQ+ + +E+ Q E
Sbjct: 933 LTKMNDELRLKERDVEELQLKLTKANENASFLQKSIEDM-TVKAEQSQQEAAKKHEEEKK 991
Query: 457 EGEGPQNPEETDEKVEEPEQQ------NKSSAVGPPEKVRRFTLDRLKQLGVDVSIKPRL 510
E E + + ++K+E Q A + L L++ +D K +
Sbjct: 992 ELE--RKLSDLEKKMETSHNQCQELKARYERATSETKTKHEEILQNLQKTLLDTEDKLKG 1049
Query: 511 GADEDSFVILEPETNRELEALKQRFWKHANPAAKPRAGQTVNVNVIVKDMGTDGKEELKA 570
+E+S ++ +ELE L+++ A K +A QT + + + T K E A
Sbjct: 1050 AREENSGLL------QELEELRKQ-------ADKAKAAQTAEDAMQIMEQMTKEKTETLA 1096
Query: 571 DVVPVTLAPKKLDGASHTKPGEKL----------QVLKAKLQEAMKLRRFEERQKRQALF 620
+ KL T L ++L + Q+ + R+ E K+ A
Sbjct: 1097 SLEDTKQTNAKLQNELDTLKENNLKNVEELNKSKELLTVENQKMEEFRKEIETLKQAAAQ 1156
Query: 621 KLDNEDGFEEEEEE--EEEMTDESEEDGEEKVEKEEK--EEELEEEEEKEEEEEEEGNQE 676
K +EE + EE E +K+E+E +L E +++E + ++ ++E
Sbjct: 1157 KSQQLSALQEENVKLAEELGRSRDEVTSHQKLEEERSVLNNQLLEMKKRESKFIKDADEE 1216
Query: 677 TAEFLLS---SEEIETKDEKEMDKENNDGS---SEIGKAVGFLSVPKSLSSDSTLLLFKD 730
A S + + T+ + E++K N+ + E A SV ++L SD L K
Sbjct: 1217 KASLQKSISITSALLTEKDAELEKLRNEVTVLRGENASAKSLHSVVQTLESDKVKLELKV 1276
Query: 731 SSSKMGYFPTEEKSETDENSGKQPSKLDEDDSCSLLTKESSHNSSFELIGSTIPSYQPCN 790
+ ++ E K + +SG ++ DED E + S + + S I Q N
Sbjct: 1277 KNLELQL--KENKRQLSSSSGNTDTQADED--------ERAQESQIDFLNSVIVDLQRKN 1326
Query: 791 R 791
+
Sbjct: 1327 Q 1327
Score = 52.8 bits (125), Expect = 2e-06
Identities = 126/652 (19%), Positives = 256/652 (39%), Gaps = 102/652 (15%)
Query: 133 ELSLQSGNSTDFTTDRKSSKKHIHDKEGTAGKAKVKSKRRLEKEERKMEKIRQLKKKETK 192
EL+L + ++ + A + KV+ +LE+E+RK+E ++ ++E+
Sbjct: 391 ELALARDGHDQHVLELEAKMDQLRTMVEAADREKVELLNQLEEEKRKVEDLQFRVEEESI 450
Query: 193 NQED-------------DVEQP--FNDSGCLLVDKDLFETG----------LEDENNSPL 227
+ D ++EQ F + + ++L +T +E E + L
Sbjct: 451 TKGDLETQTKLEHARIKELEQSLLFEKTKADKLQRELEDTRVATVSEKSRIMELEKDLAL 510
Query: 228 EDEESLESIRAAVKNKVKKHKKKEPSLESGVHSFEEGSELSKG------TTRKERKAAR- 280
+E E R NK SL + S +E E+++ T+ KE AR
Sbjct: 511 RVQEVAELRRRLESNKPAGDVDMSLSLLQEISSLQEKLEVTRTDHQREITSLKEHFGARE 570
Query: 281 -LSKEALKQLHSETQRLIRESAL---NLPYHMPENKTIHDFFKRKPRPTC--HGNAMALL 334
++ +K L++ T++L +E+ L + EN + +K K H AM L
Sbjct: 571 ETHQKEIKALYTATEKLSKENESLKSKLEHANKENSDVIALWKSKLETAIASHQQAMEEL 630
Query: 335 KSS-----KYQSSHHKEIIDTANTTEMNSDHHSKGSEQTTGAENEVETNALPVV-SKETQ 388
K S +++ E+ ++ H + + +E + + +K +
Sbjct: 631 KVSFSKGLGTETAEFAELKTQIEKMRLDYQHEIENLQNQQDSERAAHAKEMEALRAKLMK 690
Query: 389 IITGSDESCRKDLVKNEELEIQEKQKQSDIRPSPGDSSVLQQESNFLGNNHSEECQV--- 445
+I + S K ++ E Q + D ++ + +E L +E+ +V
Sbjct: 691 VIKEKENSLEAIRSKLDKAEDQHLVEMEDTLNKLQEAEIKVKELEVLQAKCNEQTKVIDN 750
Query: 446 --GGLVAFEPHALE--------GEGPQNPEETDEKVEEPEQQNKSSAVGPPEKVRRFTLD 495
L A E L+ EG ++ +++E E+Q K + + + +
Sbjct: 751 FTSQLKATEEKLLDLDALRKASSEGKSEMKKLRQQLEAAEKQIKHLEIEKNAESSKASSI 810
Query: 496 RLKQLGVDVSIKPRLGADEDSFVILEPETNRELEALKQRFWKHANPAAKPRAGQTVNVNV 555
+ G ++ + L + ++ +EL+ LK++F + + A + VN
Sbjct: 811 TRELQGRELKLT-NLQENLSEVSQVKETLEKELQILKEKFAEASEEAVSVQRSMQETVNK 869
Query: 556 IVKDMGTDGKEE----LKADVVPVTLAPKKLDGASHTKPGEKLQVLKAK------LQEAM 605
+ + KEE L +D+ + ++ K + Q++KAK + E M
Sbjct: 870 LHQ------KEEQFNMLSSDLEKLRENLADMEAKFREKDEREEQLIKAKEKLENDIAEIM 923
Query: 606 KLRRFEERQKRQALFKLDNEDGFEEEEEEE-------------------EEMTDESEEDG 646
K+ Q L K+++E +E + EE E+MT ++E+
Sbjct: 924 KMSGDNSSQ----LTKMNDELRLKERDVEELQLKLTKANENASFLQKSIEDMTVKAEQSQ 979
Query: 647 EEKVEK-EEKEEELEEE----EEKEEEEEEEGNQETAEFLLSSEEIETKDEK 693
+E +K EE+++ELE + E+K E + + A + ++ E +TK E+
Sbjct: 980 QEAAKKHEEEKKELERKLSDLEKKMETSHNQCQELKARYERATSETKTKHEE 1031
Score = 38.5 bits (88), Expect = 0.044
Identities = 73/376 (19%), Positives = 143/376 (38%), Gaps = 60/376 (15%)
Query: 867 TQSQLLDAD--------GFLNVRNHRNQYQALKPRLPLASMDENAMDANMDELLDLCTGK 918
T+ +LLD D G ++ R Q +A + ++ +++NA + + G+
Sbjct: 758 TEEKLLDLDALRKASSEGKSEMKKLRQQLEAAEKQIKHLEIEKNAESSKASSITRELQGR 817
Query: 919 FT--SQAEKHLPRKSDKKENMEELLNLCSGKFTSQDASTPASSELNKQEKESSMGDPMEE 976
+ +++L S KE +E+ L + KF + EE
Sbjct: 818 ELKLTNLQENLSEVSQVKETLEKELQILKEKFA----------------------EASEE 855
Query: 977 ALALCSGSFPTDKEEEDEEEEFGDFRLVSNDNEFDSDEDEHSDSGNDLALEDHEDDD-EE 1035
A+++ T + +EE+F N SD ++ ++ D+ + E D+ EE
Sbjct: 856 AVSVQRSMQETVNKLHQKEEQF---------NMLSSDLEKLRENLADMEAKFREKDEREE 906
Query: 1036 ELLKRSEKLKRQMRLRKYLEDEAEVSGSDVGSEDEYDGEEIDEYEEDVIDEVLPSDEELQ 1095
+L+K EKL+ + + ++SG D S+ +E+ E DV EELQ
Sbjct: 907 QLIKAKEKLEND------IAEIMKMSG-DNSSQLTKMNDELRLKERDV--------EELQ 951
Query: 1096 SQIKKIHMK-TMLDDDKRQLRLYQERYLADGDLHSDGPGRMRKFRWKNIDDASQMDLFHR 1154
++ K + + L + + E+ + + ++ K D +M+ H
Sbjct: 952 LKLTKANENASFLQKSIEDMTVKAEQ--SQQEAAKKHEEEKKELERKLSDLEKKMETSHN 1009
Query: 1155 DSDDDQTEEQLDESEARWRKERIEREQWLRDMAQQGKITAEEEEEIGEDSQFMILAKKVT 1214
+ + + SE + + E I + + + K+ EE G + L K+
Sbjct: 1010 QCQELKARYERATSETKTKHEEILQNLQKTLLDTEDKLKGAREENSGLLQELEELRKQAD 1069
Query: 1215 AKALQKNASRPMVIQE 1230
+ A M I E
Sbjct: 1070 KAKAAQTAEDAMQIME 1085
Score = 31.2 bits (69), Expect = 7.0
Identities = 17/81 (20%), Positives = 45/81 (55%), Gaps = 1/81 (1%)
Query: 1031 DDDEEELLKRSEKLKRQMRLRKYLEDEAEVSGSDVGSEDEYDGEEIDEYEEDVIDEVLPS 1090
D ++ ELL + E+ KR++ ++ +E ++ D+ ++ + + I E E+ ++ E +
Sbjct: 421 DREKVELLNQLEEEKRKVEDLQFRVEEESITKGDLETQTKLEHARIKELEQSLLFEKTKA 480
Query: 1091 DEELQSQIKKIHMKTMLDDDK 1111
D +LQ +++ + T+ + +
Sbjct: 481 D-KLQRELEDTRVATVSEKSR 500
>gi|21735415 centromere protein B [Homo sapiens]
Length = 599
Score = 60.1 bits (144), Expect = 1e-08
Identities = 47/145 (32%), Positives = 69/145 (47%), Gaps = 18/145 (12%)
Query: 623 DNEDGFEEEEEEEEEMTDESEEDGEEKVEKEEKEEELEEEEEKEEE------EEEEGNQE 676
+ E+ EEEEEEEE +E EE+GEE+ E+ + EEL EEEE EEE EEEE ++E
Sbjct: 406 EEEEEEEEEEEEEEGEGEEEEEEGEEEEEEGGEGEELGEEEEVEEEGDVDSDEEEEEDEE 465
Query: 677 TAEFLLSSEEIETKDEKEMDKENNDGSSEIGKAVGFLSVPKSLSSDSTLLLFKDSSSKMG 736
+ SSE +E +D + G E G + G + + L S
Sbjct: 466 S-----SSEGLEAEDWAQ-------GVVEAGGSFGAYGAQEEAQCPTLHFLEGGEDSDSD 513
Query: 737 YFPTEEKSETDENSGKQPSKLDEDD 761
+++ E DE+ + D D+
Sbjct: 514 SEEEDDEEEDDEDEDDDDDEEDGDE 538
Score = 52.0 bits (123), Expect = 4e-06
Identities = 28/74 (37%), Positives = 43/74 (58%)
Query: 638 MTDESEEDGEEKVEKEEKEEELEEEEEKEEEEEEEGNQETAEFLLSSEEIETKDEKEMDK 697
+T + +GEE+ E+EE+EEE E E E+EEEE EE +E E EE E ++E ++D
Sbjct: 397 ITTSLKSEGEEEEEEEEEEEEEEGEGEEEEEEGEEEEEEGGEGEELGEEEEVEEEGDVDS 456
Query: 698 ENNDGSSEIGKAVG 711
+ + E + G
Sbjct: 457 DEEEEEDEESSSEG 470
Score = 49.7 bits (117), Expect = 2e-05
Identities = 35/112 (31%), Positives = 54/112 (48%), Gaps = 21/112 (18%)
Query: 611 EERQKRQALFKLDNEDGFEEEEE--EEEEMTDESEEDGEEKVEKEEKEEELEEEEEKEEE 668
EE ++ + + + E+G EEEEE E EE+ +E E + E V+ +E+EEE EE + E
Sbjct: 413 EEEEEEEGEGEEEEEEGEEEEEEGGEGEELGEEEEVEEEGDVDSDEEEEEDEESSSEGLE 472
Query: 669 EE-------------------EEGNQETAEFLLSSEEIETKDEKEMDKENND 701
E EE T FL E+ ++ E+E D+E +D
Sbjct: 473 AEDWAQGVVEAGGSFGAYGAQEEAQCPTLHFLEGGEDSDSDSEEEDDEEEDD 524
Score = 41.6 bits (96), Expect = 0.005
Identities = 35/140 (25%), Positives = 55/140 (39%), Gaps = 25/140 (17%)
Query: 979 ALCSGSFPTDKEEEDEEEEFGDFRLVSNDNEFDSDEDEHSDSGNDLALEDHED------- 1031
A + S ++ EEE+EEEE + + E + E+E + G L + E+
Sbjct: 395 ATITTSLKSEGEEEEEEEEEEEEEEGEGEEEEEEGEEEEEEGGEGEELGEEEEVEEEGDV 454
Query: 1032 DDEEELLKRSEKLKRQMRLRKYLEDEAEVSGS------------------DVGSEDEYDG 1073
D +EE + E + + + E GS + G + + D
Sbjct: 455 DSDEEEEEDEESSSEGLEAEDWAQGVVEAGGSFGAYGAQEEAQCPTLHFLEGGEDSDSDS 514
Query: 1074 EEIDEYEEDVIDEVLPSDEE 1093
EE D+ EED DE DEE
Sbjct: 515 EEEDDEEEDDEDEDDDDDEE 534
Score = 38.5 bits (88), Expect = 0.044
Identities = 47/179 (26%), Positives = 77/179 (43%), Gaps = 27/179 (15%)
Query: 960 ELNKQEKESSMGDPMEEALALCSGSFPTDKEEEDEE----EEFGDFRLVSNDNEFDSDED 1015
E ++E+E G+ EE + EEE+EE EE G+ V + + DSDE+
Sbjct: 411 EEEEEEEEEGEGEEEEE-----------EGEEEEEEGGEGEELGEEEEVEEEGDVDSDEE 459
Query: 1016 EHSD---SGNDLALEDHEDDDEE---ELLKRSEKLKRQMRLRKYLE--DEAEVSGSDVGS 1067
E D S L ED E + + Q +LE ++++ +
Sbjct: 460 EEEDEESSSEGLEAEDWAQGVVEAGGSFGAYGAQEEAQCPTLHFLEGGEDSDSDSEEEDD 519
Query: 1068 EDEYDGEEIDEYEEDVIDEV-LPSDEELQ---SQIKKIHMKTMLDDDKRQLRLYQERYL 1122
E+E D +E D+ +E+ DEV +PS E + +K+ +DD + L+ E L
Sbjct: 520 EEEDDEDEDDDDDEEDGDEVPVPSFGEAMAYFAMVKRYLTSFPIDDRVQSHILHLEHDL 578
Score = 32.7 bits (73), Expect = 2.4
Identities = 28/118 (23%), Positives = 48/118 (40%), Gaps = 7/118 (5%)
Query: 922 QAEKHLPRKSDKKENMEELLNLCSGKFTSQDASTPASSELNKQEKESSMGDPMEE---AL 978
+ E+ +++E E L + ++ + E + E+ SS G E+ +
Sbjct: 421 EGEEEEEEGEEEEEEGGEGEELGEEEEVEEEGDVDSDEEEEEDEESSSEGLEAEDWAQGV 480
Query: 979 ALCSGSFPTDKEEEDEEEEFGDFRLVSNDNEFDSDEDEHSDSGNDLALEDHEDDDEEE 1036
GSF +E E + + + DSD +E D D ED +DDD+EE
Sbjct: 481 VEAGGSFGAYGAQE--EAQCPTLHFLEGGEDSDSDSEEEDDEEED--DEDEDDDDDEE 534
>gi|189409130 zinc finger E-box binding homeobox 1 isoform a [Homo
sapiens]
Length = 1108
Score = 60.1 bits (144), Expect = 1e-08
Identities = 39/100 (39%), Positives = 60/100 (60%), Gaps = 10/100 (10%)
Query: 612 ERQKRQALFKLDNEDGFEEEEEEEEEMTDESEEDGEEKVEKEEKEEELEEEEEKEEEEEE 671
+ +R++L + ++ED +EEEEE++EM + EE EK + +E+EE EEEEE EEEE E
Sbjct: 1005 DSDERESLTREEDEDSEKEEEEEDKEMEELQEEKECEKPQGDEEEE--EEEEEVEEEEVE 1062
Query: 672 EGNQETAEFLLSSEEIETKDEKEMDKENNDGSSEIGKAVG 711
E E EE +T+ + D+ + SS +G+ VG
Sbjct: 1063 EAENE-------GEEAKTEGLMKDDRAESQASS-LGQKVG 1094
Score = 44.3 bits (103), Expect = 8e-04
Identities = 34/123 (27%), Positives = 59/123 (47%), Gaps = 16/123 (13%)
Query: 615 KRQALFKLDNEDGFEEEEEEEEEMTDE----------SEEDGEEKVEKEEKEEELEEEEE 664
KR+A + D E+EE E +++E + D E + +EE E+ +EEEE
Sbjct: 971 KREA----EERDSTEQEEAGPEILSNEHVGARASPSQGDSDERESLTREEDEDSEKEEEE 1026
Query: 665 KEEEEEEEGNQETAEFLLSSEEIETKDE--KEMDKENNDGSSEIGKAVGFLSVPKSLSSD 722
+++E EE ++ E EE E ++E +E + E + E K G + ++ S
Sbjct: 1027 EDKEMEELQEEKECEKPQGDEEEEEEEEEVEEEEVEEAENEGEEAKTEGLMKDDRAESQA 1086
Query: 723 STL 725
S+L
Sbjct: 1087 SSL 1089
Score = 40.8 bits (94), Expect = 0.009
Identities = 35/124 (28%), Positives = 56/124 (45%), Gaps = 13/124 (10%)
Query: 988 DKEEEDEEEEFGDFRLVSNDNEFDSDEDEHSDSGNDLALEDHEDDD----EEELLKRSEK 1043
++ + E+EE G ++SN++ DS +L ED+D EEE K E+
Sbjct: 975 EERDSTEQEEAGP-EILSNEHVGARASPSQGDSDERESLTREEDEDSEKEEEEEDKEMEE 1033
Query: 1044 LKRQMRLRKYLEDEAEVSGSDVGSEDEYDGEEIDEYE---EDVIDEVLPSDEELQSQIKK 1100
L+ + K DE E E+E + EE++E E E+ E L D+ +SQ
Sbjct: 1034 LQEEKECEKPQGDEEEEE-----EEEEVEEEEVEEAENEGEEAKTEGLMKDDRAESQASS 1088
Query: 1101 IHMK 1104
+ K
Sbjct: 1089 LGQK 1092
Score = 40.4 bits (93), Expect = 0.012
Identities = 28/84 (33%), Positives = 45/84 (53%), Gaps = 5/84 (5%)
Query: 611 EERQKRQALFKLDNEDGFEEEEEEEEEMTDESEEDGEEKVEKEEKEEELEEEEEKEEEEE 670
+E ++ Q + + G EEEEEEEEE+ +E E+ E + E E K E L +++ E +
Sbjct: 1029 KEMEELQEEKECEKPQGDEEEEEEEEEVEEEEVEEAENEGE-EAKTEGLMKDDRAESQAS 1087
Query: 671 EEGNQETAEFLLSSEEIETKDEKE 694
G Q+ E SSE++ + E
Sbjct: 1088 SLG-QKVGE---SSEQVSEEKTNE 1107
Score = 37.7 bits (86), Expect = 0.075
Identities = 31/132 (23%), Positives = 57/132 (43%), Gaps = 11/132 (8%)
Query: 949 TSQDASTPA--SSELNKQEKESSMGDPMEEALALCSGSFPTDKEEEDEEEEFGDFRLVSN 1006
T Q+ + P S+E S GD E ++KEEE+E++E + +
Sbjct: 980 TEQEEAGPEILSNEHVGARASPSQGDSDERESLTREEDEDSEKEEEEEDKEMEELQEEKE 1039
Query: 1007 DNEFDSDEDEHSDSGNDLALEDHEDDDEEELLKRSEKLKRQMRLRKYLEDEAEVSGSDVG 1066
+ DE+E + E+ E+++ EE E+ K + ++ +D AE S +G
Sbjct: 1040 CEKPQGDEEEEEEE------EEVEEEEVEEAENEGEEAKTEGLMK---DDRAESQASSLG 1090
Query: 1067 SEDEYDGEEIDE 1078
+ E++ E
Sbjct: 1091 QKVGESSEQVSE 1102
>gi|189409128 zinc finger E-box binding homeobox 1 isoform b [Homo
sapiens]
Length = 1124
Score = 60.1 bits (144), Expect = 1e-08
Identities = 39/100 (39%), Positives = 60/100 (60%), Gaps = 10/100 (10%)
Query: 612 ERQKRQALFKLDNEDGFEEEEEEEEEMTDESEEDGEEKVEKEEKEEELEEEEEKEEEEEE 671
+ +R++L + ++ED +EEEEE++EM + EE EK + +E+EE EEEEE EEEE E
Sbjct: 1021 DSDERESLTREEDEDSEKEEEEEDKEMEELQEEKECEKPQGDEEEE--EEEEEVEEEEVE 1078
Query: 672 EGNQETAEFLLSSEEIETKDEKEMDKENNDGSSEIGKAVG 711
E E EE +T+ + D+ + SS +G+ VG
Sbjct: 1079 EAENE-------GEEAKTEGLMKDDRAESQASS-LGQKVG 1110
Score = 44.3 bits (103), Expect = 8e-04
Identities = 34/123 (27%), Positives = 59/123 (47%), Gaps = 16/123 (13%)
Query: 615 KRQALFKLDNEDGFEEEEEEEEEMTDE----------SEEDGEEKVEKEEKEEELEEEEE 664
KR+A + D E+EE E +++E + D E + +EE E+ +EEEE
Sbjct: 987 KREA----EERDSTEQEEAGPEILSNEHVGARASPSQGDSDERESLTREEDEDSEKEEEE 1042
Query: 665 KEEEEEEEGNQETAEFLLSSEEIETKDE--KEMDKENNDGSSEIGKAVGFLSVPKSLSSD 722
+++E EE ++ E EE E ++E +E + E + E K G + ++ S
Sbjct: 1043 EDKEMEELQEEKECEKPQGDEEEEEEEEEVEEEEVEEAENEGEEAKTEGLMKDDRAESQA 1102
Query: 723 STL 725
S+L
Sbjct: 1103 SSL 1105
Score = 40.8 bits (94), Expect = 0.009
Identities = 35/124 (28%), Positives = 56/124 (45%), Gaps = 13/124 (10%)
Query: 988 DKEEEDEEEEFGDFRLVSNDNEFDSDEDEHSDSGNDLALEDHEDDD----EEELLKRSEK 1043
++ + E+EE G ++SN++ DS +L ED+D EEE K E+
Sbjct: 991 EERDSTEQEEAGP-EILSNEHVGARASPSQGDSDERESLTREEDEDSEKEEEEEDKEMEE 1049
Query: 1044 LKRQMRLRKYLEDEAEVSGSDVGSEDEYDGEEIDEYE---EDVIDEVLPSDEELQSQIKK 1100
L+ + K DE E E+E + EE++E E E+ E L D+ +SQ
Sbjct: 1050 LQEEKECEKPQGDEEEEE-----EEEEVEEEEVEEAENEGEEAKTEGLMKDDRAESQASS 1104
Query: 1101 IHMK 1104
+ K
Sbjct: 1105 LGQK 1108
Score = 40.4 bits (93), Expect = 0.012
Identities = 28/84 (33%), Positives = 45/84 (53%), Gaps = 5/84 (5%)
Query: 611 EERQKRQALFKLDNEDGFEEEEEEEEEMTDESEEDGEEKVEKEEKEEELEEEEEKEEEEE 670
+E ++ Q + + G EEEEEEEEE+ +E E+ E + E E K E L +++ E +
Sbjct: 1045 KEMEELQEEKECEKPQGDEEEEEEEEEVEEEEVEEAENEGE-EAKTEGLMKDDRAESQAS 1103
Query: 671 EEGNQETAEFLLSSEEIETKDEKE 694
G Q+ E SSE++ + E
Sbjct: 1104 SLG-QKVGE---SSEQVSEEKTNE 1123
Score = 37.7 bits (86), Expect = 0.075
Identities = 31/132 (23%), Positives = 57/132 (43%), Gaps = 11/132 (8%)
Query: 949 TSQDASTPA--SSELNKQEKESSMGDPMEEALALCSGSFPTDKEEEDEEEEFGDFRLVSN 1006
T Q+ + P S+E S GD E ++KEEE+E++E + +
Sbjct: 996 TEQEEAGPEILSNEHVGARASPSQGDSDERESLTREEDEDSEKEEEEEDKEMEELQEEKE 1055
Query: 1007 DNEFDSDEDEHSDSGNDLALEDHEDDDEEELLKRSEKLKRQMRLRKYLEDEAEVSGSDVG 1066
+ DE+E + E+ E+++ EE E+ K + ++ +D AE S +G
Sbjct: 1056 CEKPQGDEEEEEEE------EEVEEEEVEEAENEGEEAKTEGLMK---DDRAESQASSLG 1106
Query: 1067 SEDEYDGEEIDE 1078
+ E++ E
Sbjct: 1107 QKVGESSEQVSE 1118
Database: hs.faa
Posted date: Aug 4, 2009 4:42 PM
Number of letters in database: 18,247,518
Number of sequences in database: 37,866
Lambda K H
0.305 0.125 0.336
Gapped
Lambda K H
0.267 0.0410 0.140
Matrix: BLOSUM62
Gap Penalties: Existence: 11, Extension: 1
Number of Hits to DB: 54,766,035
Number of Sequences: 37866
Number of extensions: 2982718
Number of successful extensions: 87085
Number of sequences better than 10.0: 30
Number of HSP's better than 10.0 without gapping: 1083
Number of HSP's successfully gapped in prelim test: 1035
Number of HSP's that attempted gapping in prelim test: 19033
Number of HSP's gapped (non-prelim): 25393
length of query: 1339
length of database: 18,247,518
effective HSP length: 114
effective length of query: 1225
effective length of database: 13,930,794
effective search space: 17065222650
effective search space used: 17065222650
T: 11
A: 40
X1: 16 ( 7.0 bits)
X2: 38 (14.6 bits)
X3: 64 (24.7 bits)
S1: 43 (21.9 bits)
S2: 68 (30.8 bits)
Search results were obtained with NCBI BLAST and RefSeq entries.
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Guide to the Human Genome
Copyright © 2010 by Stewart Scherer. All rights reserved.