Search of human proteins with 21614531

Search of human proteins with 21614531

BLASTP 2.2.11 [Jun-05-2005]


Reference: Altschul, Stephen F., Thomas L. Madden, Alejandro A. Schaffer, 
Jinghui Zhang, Zheng Zhang, Webb Miller, and David J. Lipman (1997), 
"Gapped BLAST and PSI-BLAST: a new generation of protein database search
programs",  Nucleic Acids Res. 25:3389-3402.

Query= gi|21614531 testisin isoform 2 [Homo sapiens]
         (312 letters)

Database: hs.faa 
           37,866 sequences; 18,247,518 total letters

Searching..................................................done

                                                                 Score    E
Sequences producing significant alignments:                      (bits) Value

gi|21614531 testisin isoform 2 [Homo sapiens]                         665   0.0  
gi|5803197 testisin isoform 1 [Homo sapiens]                          660   0.0  
gi|21614533 testisin isoform 3 [Homo sapiens]                         620   e-178
gi|205360905 testis-specific serine protease 1 [Homo sapiens]         336   1e-92
gi|156938340 transmembrane tryptase preproprotein [Homo sapiens]      225   4e-59
gi|13994276 marapsin [Homo sapiens]                                   219   2e-57
gi|4506153 prostasin preproprotein [Homo sapiens]                     215   4e-56
gi|11545839 protease, serine, 22 [Homo sapiens]                       207   1e-53
gi|148806900 epidermis-specific serine protease-like protein [Ho...   202   2e-52
gi|68508970 tryptase beta 2 precursor [Homo sapiens]                  198   4e-51
gi|58218970 protease, serine, 36 [Homo sapiens]                       198   4e-51
gi|116256363 transmembrane protease, serine 13 [Homo sapiens]         197   1e-50
gi|23957702 transmembrane protease, serine 6 [Homo sapiens]           197   1e-50
gi|13775595 tryptase alpha/beta 1 precursor [Homo sapiens]            196   2e-50
gi|78191798 plasma kallikrein B1 precursor [Homo sapiens]             194   1e-49
gi|13173471 transmembrane protease, serine 3 isoform 1 [Homo sap...   192   2e-49
gi|239753545 PREDICTED: similar to hCG2041452 [Homo sapiens]          191   7e-49
gi|239748117 PREDICTED: hypothetical protein XP_002346556 [Homo ...   191   7e-49
gi|239742016 PREDICTED: hypothetical protein XP_002342392 [Homo ...   191   7e-49
gi|117956391 protease, serine, 33 [Homo sapiens]                      189   4e-48
gi|4758508 transmembrane protease, serine 11D [Homo sapiens]          188   5e-48
gi|33667063 transmembrane protease, serine 9 [Homo sapiens]           184   9e-47
gi|4503627 coagulation factor XI precursor [Homo sapiens]             182   3e-46
gi|227499990 transmembrane protease, serine 2 isoform 1 [Homo sa...   181   6e-46
gi|205360943 transmembrane protease, serine 2 isoform 2 [Homo sa...   181   6e-46
gi|145701030 transmembrane protease, serine 4 isoform 3 [Homo sa...   180   2e-45
gi|15451940 transmembrane protease, serine 4 isoform 1 [Homo sap...   180   2e-45
gi|33186882 testis serine protease 2 [Homo sapiens]                   180   2e-45
gi|33695155 hepsin [Homo sapiens]                                     179   2e-45
gi|4504481 hepsin [Homo sapiens]                                      179   2e-45

>gi|21614531 testisin isoform 2 [Homo sapiens]
          Length = 312

 Score =  665 bits (1717), Expect = 0.0
 Identities = 312/312 (100%), Positives = 312/312 (100%)

Query: 1   MGARGALLLALLLARAGLRKPESQEAAPLSGPCGRRVITSRIVGGEDAELGRWPWQGSLR 60
           MGARGALLLALLLARAGLRKPESQEAAPLSGPCGRRVITSRIVGGEDAELGRWPWQGSLR
Sbjct: 1   MGARGALLLALLLARAGLRKPESQEAAPLSGPCGRRVITSRIVGGEDAELGRWPWQGSLR 60

Query: 61  LWDSHVCGVSLLSHRWALTAAHCFETDLSDPSGWMVQFGQLTSMPSFWSLQAYYTRYFVS 120
           LWDSHVCGVSLLSHRWALTAAHCFETDLSDPSGWMVQFGQLTSMPSFWSLQAYYTRYFVS
Sbjct: 61  LWDSHVCGVSLLSHRWALTAAHCFETDLSDPSGWMVQFGQLTSMPSFWSLQAYYTRYFVS 120

Query: 121 NIYLSPRYLGNSPYDIALVKLSAPVTYTKHIQPICLQASTFEFENRTDCWVTGWGYIKED 180
           NIYLSPRYLGNSPYDIALVKLSAPVTYTKHIQPICLQASTFEFENRTDCWVTGWGYIKED
Sbjct: 121 NIYLSPRYLGNSPYDIALVKLSAPVTYTKHIQPICLQASTFEFENRTDCWVTGWGYIKED 180

Query: 181 EALPSPHTLQEVQVAIINNSMCNHLFLKYSFRKDIFGDMVCAGNAQGGKDACFGDSGGPL 240
           EALPSPHTLQEVQVAIINNSMCNHLFLKYSFRKDIFGDMVCAGNAQGGKDACFGDSGGPL
Sbjct: 181 EALPSPHTLQEVQVAIINNSMCNHLFLKYSFRKDIFGDMVCAGNAQGGKDACFGDSGGPL 240

Query: 241 ACNKNGLWYQIGVVSWGVGCGRPNRPGVYTNISHHFEWIQKLMAQSGMSQPDPSWPLLFF 300
           ACNKNGLWYQIGVVSWGVGCGRPNRPGVYTNISHHFEWIQKLMAQSGMSQPDPSWPLLFF
Sbjct: 241 ACNKNGLWYQIGVVSWGVGCGRPNRPGVYTNISHHFEWIQKLMAQSGMSQPDPSWPLLFF 300

Query: 301 PLLWALPLLGPV 312
           PLLWALPLLGPV
Sbjct: 301 PLLWALPLLGPV 312


>gi|5803197 testisin isoform 1 [Homo sapiens]
          Length = 314

 Score =  660 bits (1704), Expect = 0.0
 Identities = 312/314 (99%), Positives = 312/314 (99%), Gaps = 2/314 (0%)

Query: 1   MGARGALLLALLLARAGLRKPESQEAAPLSGPCGRRVITSRIVGGEDAELGRWPWQGSLR 60
           MGARGALLLALLLARAGLRKPESQEAAPLSGPCGRRVITSRIVGGEDAELGRWPWQGSLR
Sbjct: 1   MGARGALLLALLLARAGLRKPESQEAAPLSGPCGRRVITSRIVGGEDAELGRWPWQGSLR 60

Query: 61  LWDSHVCGVSLLSHRWALTAAHCFET--DLSDPSGWMVQFGQLTSMPSFWSLQAYYTRYF 118
           LWDSHVCGVSLLSHRWALTAAHCFET  DLSDPSGWMVQFGQLTSMPSFWSLQAYYTRYF
Sbjct: 61  LWDSHVCGVSLLSHRWALTAAHCFETYSDLSDPSGWMVQFGQLTSMPSFWSLQAYYTRYF 120

Query: 119 VSNIYLSPRYLGNSPYDIALVKLSAPVTYTKHIQPICLQASTFEFENRTDCWVTGWGYIK 178
           VSNIYLSPRYLGNSPYDIALVKLSAPVTYTKHIQPICLQASTFEFENRTDCWVTGWGYIK
Sbjct: 121 VSNIYLSPRYLGNSPYDIALVKLSAPVTYTKHIQPICLQASTFEFENRTDCWVTGWGYIK 180

Query: 179 EDEALPSPHTLQEVQVAIINNSMCNHLFLKYSFRKDIFGDMVCAGNAQGGKDACFGDSGG 238
           EDEALPSPHTLQEVQVAIINNSMCNHLFLKYSFRKDIFGDMVCAGNAQGGKDACFGDSGG
Sbjct: 181 EDEALPSPHTLQEVQVAIINNSMCNHLFLKYSFRKDIFGDMVCAGNAQGGKDACFGDSGG 240

Query: 239 PLACNKNGLWYQIGVVSWGVGCGRPNRPGVYTNISHHFEWIQKLMAQSGMSQPDPSWPLL 298
           PLACNKNGLWYQIGVVSWGVGCGRPNRPGVYTNISHHFEWIQKLMAQSGMSQPDPSWPLL
Sbjct: 241 PLACNKNGLWYQIGVVSWGVGCGRPNRPGVYTNISHHFEWIQKLMAQSGMSQPDPSWPLL 300

Query: 299 FFPLLWALPLLGPV 312
           FFPLLWALPLLGPV
Sbjct: 301 FFPLLWALPLLGPV 314


>gi|21614533 testisin isoform 3 [Homo sapiens]
          Length = 300

 Score =  620 bits (1599), Expect = e-178
 Identities = 298/314 (94%), Positives = 298/314 (94%), Gaps = 16/314 (5%)

Query: 1   MGARGALLLALLLARAGLRKPESQEAAPLSGPCGRRVITSRIVGGEDAELGRWPWQGSLR 60
           MGARGALLLALLLARAGLRKPESQEAAPLSGPCGRRVITSRIVGGEDAELGRWPWQGSLR
Sbjct: 1   MGARGALLLALLLARAGLRKPESQEAAPLSGPCGRRVITSRIVGGEDAELGRWPWQGSLR 60

Query: 61  LWDSHVCGVSLLSHRWALTAAHCFET--DLSDPSGWMVQFGQLTSMPSFWSLQAYYTRYF 118
           LWDSHVCGVSLLSHRWALTAAHCFET  DLSDPSGWMVQFGQLTSMPSFWSLQAYYTRYF
Sbjct: 61  LWDSHVCGVSLLSHRWALTAAHCFETYSDLSDPSGWMVQFGQLTSMPSFWSLQAYYTRYF 120

Query: 119 VSNIYLSPRYLGNSPYDIALVKLSAPVTYTKHIQPICLQASTFEFENRTDCWVTGWGYIK 178
           VSNIYLSPRYLGNSPYDIALVKLSAPVTYTKHIQPICLQASTFEFENRTDCWVTGWGYIK
Sbjct: 121 VSNIYLSPRYLGNSPYDIALVKLSAPVTYTKHIQPICLQASTFEFENRTDCWVTGWGYIK 180

Query: 179 EDEALPSPHTLQEVQVAIINNSMCNHLFLKYSFRKDIFGDMVCAGNAQGGKDACFGDSGG 238
           EDEALPSPHTLQEVQVAIINNSMCNHLFLKYSFRKDIFGDM              GDSGG
Sbjct: 181 EDEALPSPHTLQEVQVAIINNSMCNHLFLKYSFRKDIFGDM--------------GDSGG 226

Query: 239 PLACNKNGLWYQIGVVSWGVGCGRPNRPGVYTNISHHFEWIQKLMAQSGMSQPDPSWPLL 298
           PLACNKNGLWYQIGVVSWGVGCGRPNRPGVYTNISHHFEWIQKLMAQSGMSQPDPSWPLL
Sbjct: 227 PLACNKNGLWYQIGVVSWGVGCGRPNRPGVYTNISHHFEWIQKLMAQSGMSQPDPSWPLL 286

Query: 299 FFPLLWALPLLGPV 312
           FFPLLWALPLLGPV
Sbjct: 287 FFPLLWALPLLGPV 300


>gi|205360905 testis-specific serine protease 1 [Homo sapiens]
          Length = 318

 Score =  336 bits (862), Expect = 1e-92
 Identities = 172/320 (53%), Positives = 217/320 (67%), Gaps = 18/320 (5%)

Query: 1   MGARGALLLALLLARAGLRKPESQEAAPLSGP--------------CGRRVITSRIVGGE 46
           MGARGALLLALLLARAGL KP  +  A  +GP              CG R I + + GG 
Sbjct: 1   MGARGALLLALLLARAGLGKP-GELGALQAGPGAARRPGGGGREEACGHREIHALVAGGV 59

Query: 47  DAELGRWPWQGSLRLWDSHVCGVSLLSHRWALTAAHCFETDLSDPSGWMVQFGQLTSMPS 106
           ++  GRWPWQ SLRL   H CG SLLS RW L+AAHCF+     PS W VQ G+LTS P+
Sbjct: 60  ESARGRWPWQASLRLRRRHRCGGSLLSRRWVLSAAHCFQKHYY-PSEWTVQLGELTSRPT 118

Query: 107 FWSLQAYYTRYFVSNIYLSPRYLGNSPYDIALVKLSAPVTYTKHIQPICLQASTFEFENR 166
            W+L+AY +RY V +I ++P  LG    DIAL++L++ VTY  +IQPIC+++STF F +R
Sbjct: 119 PWNLRAYSSRYKVQDIIVNPDALGVLRNDIALLRLASSVTYNAYIQPICIESSTFNFVHR 178

Query: 167 TDCWVTGWGYIKEDEA-LPSPHTLQEVQVAIINNSMCNHLFLKYSFRKDIFGDMVCAGNA 225
            DCWVTGWG I      LP P+ L+E QV I+NN+ CN+LF + S R  I+  M CAG  
Sbjct: 179 PDCWVTGWGLISPSGTPLPPPYNLREAQVTILNNTRCNYLFEQPSSRSMIWDSMFCAGAE 238

Query: 226 QGGKDACFGDSGGPLACNKNGLWYQIGVVSWGVGCGRPNRPGVYTNISHHFEWIQKLMAQ 285
            G  D C GDSGGPL C+K+GLWYQ+G+VSWG+ CG+PNRPGVYTNIS +F WI+++M+ 
Sbjct: 239 DGSVDTCKGDSGGPLVCDKDGLWYQVGIVSWGMDCGQPNRPGVYTNISVYFHWIRRVMSH 298

Query: 286 SGMSQPDPSWPLLFFPLLWA 305
           S   +P+PS  LL   LLWA
Sbjct: 299 S-TPRPNPSQLLLLLALLWA 317


>gi|156938340 transmembrane tryptase preproprotein [Homo sapiens]
          Length = 321

 Score =  225 bits (573), Expect = 4e-59
 Identities = 139/321 (43%), Positives = 178/321 (55%), Gaps = 43/321 (13%)

Query: 3   ARGALLLALLLARAGLRKPESQEAAPLSGPCGRRVITS---RIVGGEDAELGRWPWQGSL 59
           A GA  L LLLA  G+          L   CGR  ++    RIVGG  A  G WPWQ SL
Sbjct: 2   ALGACGLLLLLAVPGV------SLRTLQPGCGRPQVSDAGGRIVGGHAAPAGAWPWQASL 55

Query: 60  RLWDSHVCGVSLLSHRWALTAAHCFETDLSDPSGWMVQFGQL--TSMPSFWSLQAYYTRY 117
           RL   HVCG SLLS +W LTAAHCF   L+  S + V  G+L  T  P F +++      
Sbjct: 56  RLRRVHVCGGSLLSPQWVLTAAHCFSGSLNS-SDYQVHLGELEITLSPHFSTVRQII--- 111

Query: 118 FVSNIYLSPRYLGNSPYDIALVKLSAPVTYTKHIQPICLQASTFEFENRTDCWVTGWGYI 177
               ++ SP     +  DIALV+LS PVT +  I P+CL  ++ +F     CWVTGWGY 
Sbjct: 112 ----LHSSPSGQPGTSGDIALVELSVPVTLSSRILPVCLPEASDDFCPGIRCWVTGWGYT 167

Query: 178 KEDEALPSPHTLQEVQVAIINNSMCNHLFLKYSFRKDIFG--------DMVCAGNAQGGK 229
           +E E LP P++L+EV+V++++   C         R+D  G        DM+CA   +G  
Sbjct: 168 REGEPLPPPYSLREVKVSVVDTETC---------RRDYPGPGGSILQPDMLCA---RGPG 215

Query: 230 DACFGDSGGPLACNKNGLWYQIGVVSWGVGCGRPNRPGVYTNISHHFEWIQKLMAQSGMS 289
           DAC  DSGGPL C  NG W Q G+VSWG GCGRPNRPGVYT +  +  WI++ +  SG S
Sbjct: 216 DACQDDSGGPLVCQVNGAWVQAGIVSWGEGCGRPNRPGVYTRVPAYVNWIRRHITASGGS 275

Query: 290 QPD-PSWPLL---FFPLLWAL 306
           +   P  PLL   F P L+ L
Sbjct: 276 ESGYPRLPLLAGFFLPGLFLL 296


>gi|13994276 marapsin [Homo sapiens]
          Length = 290

 Score =  219 bits (558), Expect = 2e-57
 Identities = 121/285 (42%), Positives = 166/285 (58%), Gaps = 16/285 (5%)

Query: 4   RGALLLALLLARAGLRKPESQEAAPLSGPCGRRVITSRIVGGEDAELGRWPWQGSLRLWD 63
           R A +  LLL   G ++ ++  A      CGR  + +R+VGG+D + G WPWQ S++   
Sbjct: 3   RPAAVPLLLLLCFGSQRAKAATA------CGRPRMLNRMVGGQDTQEGEWPWQVSIQRNG 56

Query: 64  SHVCGVSLLSHRWALTAAHCFETDLSDPSGWMVQFGQLTSMPSFWSLQAYYTRYFVSNIY 123
           SH CG SL++ +W LTAAHCF  + S+ S + V  G    +       A Y R  V  + 
Sbjct: 57  SHFCGGSLIAEQWVLTAAHCFR-NTSETSLYQVLLGARQLVQP--GPHAMYAR--VRQVE 111

Query: 124 LSPRYLGN-SPYDIALVKLSAPVTYTKHIQPICLQASTFEFENRTDCWVTGWGYIKEDEA 182
            +P Y G  S  D+ALV+L APV +T +I P+CL   +  FE   +CWVTGWG   E++ 
Sbjct: 112 SNPLYQGTASSADVALVELEAPVPFTNYILPVCLPDPSVIFETGMNCWVTGWGSPSEEDL 171

Query: 183 LPSPHTLQEVQVAIINNSMCNHLFLK---YSFR-KDIFGDMVCAGNAQGGKDACFGDSGG 238
           LP P  LQ++ V II+   CN L+ K   + ++ K I  DM+CAG  +G KDAC GDSGG
Sbjct: 172 LPEPRILQKLAVPIIDTPKCNLLYSKDTEFGYQPKTIKNDMLCAGFEEGKKDACKGDSGG 231

Query: 239 PLACNKNGLWYQIGVVSWGVGCGRPNRPGVYTNISHHFEWIQKLM 283
           PL C     W Q GV+SWG GC R NRPGVY  ++ H  WI +++
Sbjct: 232 PLVCLVGQSWLQAGVISWGEGCARQNRPGVYIRVTAHHNWIHRII 276


>gi|4506153 prostasin preproprotein [Homo sapiens]
          Length = 343

 Score =  215 bits (548), Expect = 4e-56
 Identities = 134/334 (40%), Positives = 179/334 (53%), Gaps = 41/334 (12%)

Query: 9   LALLLARAGLRKPESQEAAPLSGPCGRRVITSRIVGGEDAELGRWPWQGSLRLWDSHVCG 68
           +A+LL    LR     E A    PCG     +RI GG  A  G+WPWQ S+     HVCG
Sbjct: 15  VAILLYLGLLRSGTGAEGA--EAPCGVAP-QARITGGSSAVAGQWPWQVSITYEGVHVCG 71

Query: 69  VSLLSHRWALTAAHCFETDLSDPSGWMVQFG--QLTSMPSFWSLQAYYTRYFVSNIYLSP 126
            SL+S +W L+AAHCF ++      + V+ G  QL S      +        + +I   P
Sbjct: 72  GSLVSEQWVLSAAHCFPSE-HHKEAYEVKLGAHQLDSYSEDAKVST------LKDIIPHP 124

Query: 127 RYLGN-SPYDIALVKLSAPVTYTKHIQPICLQASTFEFENRTDCWVTGWGYIKEDEALPS 185
            YL   S  DIAL++LS P+T++++I+PICL A+   F N   C VTGWG++    +L +
Sbjct: 125 SYLQEGSQGDIALLQLSRPITFSRYIRPICLPAANASFPNGLHCTVTGWGHVAPSVSLLT 184

Query: 186 PHTLQEVQVAIINNSMCNHLF---LKYSFRKDIFGDMVCAGNAQGGKDACFGDSGGPLAC 242
           P  LQ+++V +I+   CN L+    K      +  DMVCAG  +GGKDAC GDSGGPL+C
Sbjct: 185 PKPLQQLEVPLISRETCNCLYNIDAKPEEPHFVQEDMVCAGYVEGGKDACQGDSGGPLSC 244

Query: 243 NKNGLWYQIGVVSWGVGCGRPNRPGVYTNISHHFEWIQ--------KLMAQSGMSQPDPS 294
              GLWY  G+VSWG  CG  NRPGVYT  S +  WIQ        +++ Q+  SQPD +
Sbjct: 245 PVEGLWYLTGIVSWGDACGARNRPGVYTLASSYASWIQSKVTELQPRVVPQTQESQPDSN 304

Query: 295 W-----------------PLLFFPLLWALPLLGP 311
                             P+LF PL  AL LL P
Sbjct: 305 LCGSHLAFSSAPAQGLLRPILFLPLGLALGLLSP 338


>gi|11545839 protease, serine, 22 [Homo sapiens]
          Length = 317

 Score =  207 bits (526), Expect = 1e-53
 Identities = 106/287 (36%), Positives = 162/287 (56%), Gaps = 15/287 (5%)

Query: 2   GARGALLLALLLARAGLRKPESQEAAPLSGPCGRRVITSRIVGGEDAELGRWPWQGSLRL 61
           G  G     LLLA   +    +    P+   CG+    +R+VGGED+    WPW  S++ 
Sbjct: 13  GCLGTFTSLLLLASTAIL---NAARIPVPPACGKPQQLNRVVGGEDSTDSEWPWIVSIQK 69

Query: 62  WDSHVCGVSLLSHRWALTAAHCFETDLSDPSGWMVQFGQLTSMPSFWSLQAYYTR-YFVS 120
             +H C  SLL+ RW +TAAHCF+ +L+ P  + V  G        W L    +R   V 
Sbjct: 70  NGTHHCAGSLLTSRWVITAAHCFKDNLNKPYLFSVLLGA-------WQLGNPGSRSQKVG 122

Query: 121 NIYLSPR----YLGNSPYDIALVKLSAPVTYTKHIQPICLQASTFEFENRTDCWVTGWGY 176
             ++ P     +   +  DIALV+L   + +++ + PICL  ++      T CW++GWG 
Sbjct: 123 VAWVEPHPVYSWKEGACADIALVRLERSIQFSERVLPICLPDASIHLPPNTHCWISGWGS 182

Query: 177 IKEDEALPSPHTLQEVQVAIINNSMCNHLFLKYSFRKDIFGDMVCAGNAQGGKDACFGDS 236
           I++   LP P TLQ+++V II++ +C+HL+ + + +  I  DM+CAG  +G +DAC GDS
Sbjct: 183 IQDGVPLPHPQTLQKLKVPIIDSEVCSHLYWRGAGQGPITEDMLCAGYLEGERDACLGDS 242

Query: 237 GGPLACNKNGLWYQIGVVSWGVGCGRPNRPGVYTNISHHFEWIQKLM 283
           GGPL C  +G W   G++SWG GC   NRPGVY ++S H  W++K++
Sbjct: 243 GGPLMCQVDGAWLLAGIISWGEGCAERNRPGVYISLSAHRSWVEKIV 289


>gi|148806900 epidermis-specific serine protease-like protein [Homo
           sapiens]
          Length = 328

 Score =  202 bits (515), Expect = 2e-52
 Identities = 113/281 (40%), Positives = 162/281 (57%), Gaps = 14/281 (4%)

Query: 33  CGRRVITSRIVGGEDAELGRWPWQGSLRLWDSHVCGVSLLSHRWALTAAHCFETDLSDPS 92
           CG+ V +SR+VGG+DA  GRWPWQ SL    + +CG SL+S R  LTAAHC +   +  S
Sbjct: 19  CGQPVYSSRVVGGQDAAAGRWPWQVSLHFDHNFICGGSLVSERLILTAAHCIQPTWTTFS 78

Query: 93  GWMVQFGQLTSMPSFWSLQAYYTRYFVSNIYLSPRYLGNSPYDIALVKLSAPVTYTKHIQ 152
            + V  G +T   S         +Y+VS I + P+Y   +  D+AL+KLS+ VT+T  I 
Sbjct: 79  -YTVWLGSITVGDS-----RKRVKYYVSKIVIHPKYQDTTA-DVALLKLSSQVTFTSAIL 131

Query: 153 PICLQASTFEFENRTDCWVTGWGYIKEDEALPSPHTLQEVQVAIINNSMCNHLFLKY--- 209
           PICL + T +      CWVTGWG +KE         LQE +V II+   C  L+      
Sbjct: 132 PICLPSVTKQLAIPPFCWVTGWGKVKESSDRDYHSALQEAEVPIIDRQACEQLYNPIGIF 191

Query: 210 --SFRKDIFGDMVCAGNAQGGKDACFGDSGGPLACNKNGLWYQIGVVSWGVGCGRPNRPG 267
             +    I  D +CAG+ Q  KD+C GDSGGPL+C+ +G+W Q GVVSWG+ CG+ + PG
Sbjct: 192 LPALEPVIKEDKICAGDTQNMKDSCKGDSGGPLSCHIDGVWIQTGVVSWGLECGK-SLPG 250

Query: 268 VYTNISHHFEWIQKLMAQ-SGMSQPDPSWPLLFFPLLWALP 307
           VYTN+ ++ +WI   +++ + +   D  +P++   L    P
Sbjct: 251 VYTNVIYYQKWINATISRANNLDFSDFLFPIVLLSLALLRP 291


>gi|68508970 tryptase beta 2 precursor [Homo sapiens]
          Length = 275

 Score =  198 bits (504), Expect = 4e-51
 Identities = 108/264 (40%), Positives = 149/264 (56%), Gaps = 24/264 (9%)

Query: 26  AAPLSGPCGRRVITSRIVGGEDAELGRWPWQGSLRLWDS---HVCGVSLLSHRWALTAAH 82
           AAP  G   +RV    IVGG++A   +WPWQ SLR+ D    H CG SL+  +W LTAAH
Sbjct: 18  AAPAPGQALQRV---GIVGGQEAPRSKWPWQVSLRVRDRYWMHFCGGSLIHPQWVLTAAH 74

Query: 83  CFETDLSDPSGWMVQFGQLTSMPSFWSLQAYYTRYF--VSNIYLSPR-YLGNSPYDIALV 139
           C   D+ D +   VQ  +            YY      VS I + P+ Y      DIAL+
Sbjct: 75  CVGPDVKDLAALRVQLREQ---------HLYYQDQLLPVSRIIVHPQFYTAQIGADIALL 125

Query: 140 KLSAPVTYTKHIQPICLQASTFEFENRTDCWVTGWGYIKEDEALPSPHTLQEVQVAIINN 199
           +L  PV  + H+  + L  ++  F     CWVTGWG +  DE LP P  L++V+V I+ N
Sbjct: 126 ELEEPVNVSSHVHTVTLPPASETFPPGMPCWVTGWGDVDNDERLPPPFPLKQVKVPIMEN 185

Query: 200 SMCNHLFLKYSFRKD----IFGDMVCAGNAQGGKDACFGDSGGPLACNKNGLWYQIGVVS 255
            +C+  +   ++  D    +  DM+CAGN +  +D+C GDSGGPL C  NG W Q GVVS
Sbjct: 186 HICDAKYHLGAYTGDDVRIVRDDMLCAGNTR--RDSCQGDSGGPLVCKVNGTWLQAGVVS 243

Query: 256 WGVGCGRPNRPGVYTNISHHFEWI 279
           WG GC +PNRPG+YT ++++ +WI
Sbjct: 244 WGEGCAQPNRPGIYTRVTYYLDWI 267


>gi|58218970 protease, serine, 36 [Homo sapiens]
          Length = 855

 Score =  198 bits (504), Expect = 4e-51
 Identities = 104/281 (37%), Positives = 159/281 (56%), Gaps = 13/281 (4%)

Query: 21  PESQEAAPLSGPCGRRVITSRIVGGEDAELGRWPWQGSLRLWDSHVCGVSLLSHRWALTA 80
           P  +E   L   CGR   ++RIVGG +A+ G WPWQ SL     H+CG SL++  W L+A
Sbjct: 28  PTQEEPEDLD--CGRPEPSARIVGGSNAQPGTWPWQVSLHHGGGHICGGSLIAPSWVLSA 85

Query: 81  AHCFETD--LSDPSGWMVQFGQLTSMPSFWSLQAYYTRYFVSNIYLSPRYLGNSPYDIAL 138
           AHCF T+  L   + W V  G  +       L   +TR   + +  +         D+AL
Sbjct: 86  AHCFMTNGTLEPAAEWSVLLGVHSQDGP---LDGAHTRAVAAIVVPANYSQVELGADLAL 142

Query: 139 VKLSAPVTYTKHIQPICLQASTFEFENRTDCWVTGWGYIKEDEALPSPHTLQEVQVAIIN 198
           ++L++P +    + P+CL  ++  F + T CW TGWG ++E + LP P  LQEV++ ++ 
Sbjct: 143 LRLASPASLGPAVWPVCLPRASHRFVHGTACWATGWGDVQEADPLPLPWVLQEVELRLLG 202

Query: 199 NSMCNHLFLK---YSFRKDIFGDMVCAGNAQGGKDACFGDSGGPLACNKNGLWYQIGVVS 255
            + C  L+ +   ++    I   M+CAG  +G +D C GDSGGPL C + G W+Q G+ S
Sbjct: 203 EATCQCLYSQPGPFNLTLQILPGMLCAGYPEGRRDTCQGDSGGPLVCEEGGRWFQAGITS 262

Query: 256 WGVGCGRPNRPGVYTNISHHFEWIQKLMAQSGMSQPDPSWP 296
           +G GCGR NRPGV+T ++ +  WI++   Q   S+P P++P
Sbjct: 263 FGFGCGRRNRPGVFTAVATYEAWIRE---QVMGSEPGPAFP 300



 Score = 65.9 bits (159), Expect = 5e-11
 Identities = 58/245 (23%), Positives = 95/245 (38%), Gaps = 30/245 (12%)

Query: 45  GEDAELGRWPWQGSLRLWDSHVCGVSLLSHRWALTAAHCF------ETDLSDPSGWMVQF 98
           G+    G WPW+  + +  S  C  +L+S  W L  A CF      ++   D   W V  
Sbjct: 326 GKAPRPGAWPWEAQVMVPGSRPCHGALVSESWVLAPASCFLDPNSSDSPPRDLDAWRV-- 383

Query: 99  GQLTSMPSFWSLQAYYTRYFVSNIYLSPRYLGNSPYDIALVKLSAPVTYTKHIQPICLQA 158
             L S P             V+ +        ++  D+AL++L  PV  +   +P+CL  
Sbjct: 384 -LLPSRP---------RAERVARLVQHENASWDNASDLALLQLRTPVNLSAASRPVCLPH 433

Query: 159 STFEFENRTDCWVTGWGYIKEDEALPSPHTLQEVQVAIINNSMCNHLFLKYSFRKDIFGD 218
               F   + C +  WG     E    P  L E +  ++    C+ L+ +      + GD
Sbjct: 434 PEHYFLPGSRCRLARWG---RGEPALGPGALLEAE--LLGGWWCHCLYGRQGAAVPLPGD 488

Query: 219 ----MVCAGNAQGGKDACFGDSGGPLACNKNGLWYQIGVVSWGVGCGRPNRPGVYTNISH 274
               +  A   +    +C+ DS   L C + G W+  G+  +  GC RP     +  +  
Sbjct: 489 PPHALCPAYQEKEEVGSCWNDSRWSLLCQEEGTWFLAGIRDFPSGCLRPR---AFFPLQT 545

Query: 275 HFEWI 279
           H  WI
Sbjct: 546 HGPWI 550



 Score = 65.5 bits (158), Expect = 6e-11
 Identities = 75/284 (26%), Positives = 116/284 (40%), Gaps = 45/284 (15%)

Query: 22  ESQEAAPLS--GPCGRRVITSRIVGGEDAELG-RWPWQGSLRLWDSHVCGVSLLSHRWAL 78
           E+Q   P +  G CG R+        E A +G  WPW   + +    VC   LL+  W L
Sbjct: 575 ETQTCPPHTEHGACGLRL--------EAAPVGVLWPWLAEVHVAGDRVCTGILLAPGWVL 626

Query: 79  TAAHCFETDLSDPSGWM-VQFGQ--LTSMPSFWSLQAYYTRYFVSNIYLSPRYLGNSPYD 135
            A HC     S    ++ V  G+   +S+P     Q +     V +I L P++LG  P  
Sbjct: 627 AATHCVLRPGSTTVPYIEVYLGRAGASSLP-----QGHQVSRLVISIRL-PQHLGLRP-P 679

Query: 136 IALVKLSAPVTYTKHIQPICLQASTFEFENRTDCWVTGWGYIKEDEALPSPHTLQEVQVA 195
           +AL++LS+ V  +    PICL  +         CWV GW   KE    P         V+
Sbjct: 680 LALLELSSRVEPSPSALPICLHPA--GIPPGASCWVLGW---KE----PQDRVPVAAAVS 730

Query: 196 IINNSMCNHLFLKYSFRKDIFGDMVCAGNAQGGKDACFGDSGGPLACN-KNGLWYQIGVV 254
           I+   +C+ L     ++  +    +C   A+G ++ C   S  PL C    G W  +G+ 
Sbjct: 731 ILTQRICDCL-----YQGILPPGTLCVLYAEGQENRCEMTSAPPLLCQMTEGSWILVGMA 785

Query: 255 SWGVGCGRPNRPGVYTNISHHFEWIQKLMAQSGMSQP--DPSWP 296
             G          ++  I     WI + + ++    P   P WP
Sbjct: 786 VQG-------SRELFAAIGPEEAWISQTVGEANFLPPSGSPHWP 822


>gi|116256363 transmembrane protease, serine 13 [Homo sapiens]
          Length = 567

 Score =  197 bits (501), Expect = 1e-50
 Identities = 106/255 (41%), Positives = 142/255 (55%), Gaps = 17/255 (6%)

Query: 33  CGRRVITSRIVGGEDAELGRWPWQGSLRLWDSHVCGVSLLSHRWALTAAHCF-ETDLSDP 91
           CG R +T RIVGG  A   +WPWQ SL    +H+CG +L+  +W LTAAHCF  T     
Sbjct: 317 CGLRAMTGRIVGGALASDSKWPWQVSLHFGTTHICGGTLIDAQWVLTAAHCFFVTREKVL 376

Query: 92  SGWMVQFG--QLTSMPSFWSLQAYYTRYFVSNIYLSPRYLGNSP-YDIALVKLSAPVTYT 148
            GW V  G   L  +P   S         ++ I ++  Y      YDIAL++LS P+T +
Sbjct: 377 EGWKVYAGTSNLHQLPEAAS---------IAEIIINSNYTDEEDDYDIALMRLSKPLTLS 427

Query: 149 KHIQPICLQASTFEFENRTDCWVTGWGYIKEDEALPSPHTLQEVQVAIINNSMCNHLFLK 208
            HI P CL      F     CW+TG+G  +E +   SP  L+EVQV +I+   CN   + 
Sbjct: 428 AHIHPACLPMHGQTFSLNETCWITGFGKTRETDDKTSPF-LREVQVNLIDFKKCNDYLVY 486

Query: 209 YSFRKDIFGDMVCAGNAQGGKDACFGDSGGPLACNKNGLWYQIGVVSWGVGCGRPNRPGV 268
            S+   +   M+CAG+ +GG+D+C GDSGGPL C +N  WY  GV SWG GCG+ N+PGV
Sbjct: 487 DSY---LTPRMMCAGDLRGGRDSCQGDSGGPLVCEQNNRWYLAGVTSWGTGCGQRNKPGV 543

Query: 269 YTNISHHFEWIQKLM 283
           YT ++    WI   M
Sbjct: 544 YTKVTEVLPWIYSKM 558


>gi|23957702 transmembrane protease, serine 6 [Homo sapiens]
          Length = 811

 Score =  197 bits (500), Expect = 1e-50
 Identities = 104/254 (40%), Positives = 153/254 (60%), Gaps = 14/254 (5%)

Query: 33  CGRRVITSRIVGGEDAELGRWPWQGSLRLWDSHVCGVSLLSHRWALTAAHCFETD-LSDP 91
           CG +  +SRIVGG  +  G WPWQ SL++   H+CG +L++ RW +TAAHCF+ D ++  
Sbjct: 568 CGLQGPSSRIVGGAVSSEGEWPWQASLQVRGRHICGGALIADRWVITAAHCFQEDSMAST 627

Query: 92  SGWMVQFGQLTSMPSFWSLQAYYTRYFVSNIYLSPRYLGNS-PYDIALVKLSAPVTYTKH 150
             W V  G++    S W  +  +    VS + L P +  +S  YD+AL++L  PV  +  
Sbjct: 628 VLWTVFLGKVW-QNSRWPGEVSFK---VSRLLLHPYHEEDSHDYDVALLQLDHPVVRSAA 683

Query: 151 IQPICLQASTFEFENRTDCWVTGWGYIKEDEALPSPHTLQEVQVAIINNSMCNHLFLKYS 210
           ++P+CL A +  FE    CW+TGWG ++E    P  + LQ+V V +I   +C+ +     
Sbjct: 684 VRPVCLPARSHFFEPGLHCWITGWGALREGG--PISNALQKVDVQLIPQDLCSEV----- 736

Query: 211 FRKDIFGDMVCAGNAQGGKDACFGDSGGPLACNK-NGLWYQIGVVSWGVGCGRPNRPGVY 269
           +R  +   M+CAG  +G KDAC GDSGGPL C   +G W+  G+VSWG+GCGRPN  GVY
Sbjct: 737 YRYQVTPRMLCAGYRKGKKDACQGDSGGPLVCKALSGRWFLAGLVSWGLGCGRPNYFGVY 796

Query: 270 TNISHHFEWIQKLM 283
           T I+    WIQ+++
Sbjct: 797 TRITGVISWIQQVV 810


>gi|13775595 tryptase alpha/beta 1 precursor [Homo sapiens]
          Length = 275

 Score =  196 bits (499), Expect = 2e-50
 Identities = 108/265 (40%), Positives = 149/265 (56%), Gaps = 26/265 (9%)

Query: 26  AAPLSGPCGRRVITSRIVGGEDAELGRWPWQGSLRL----WDSHVCGVSLLSHRWALTAA 81
           AAP  G   +RV    IVGG++A   +WPWQ SLR+    W  H CG SL+  +W LTAA
Sbjct: 18  AAPAPGQALQRV---GIVGGQEAPRSKWPWQVSLRVHGPYW-MHFCGGSLIHPQWVLTAA 73

Query: 82  HCFETDLSDPSGWMVQFGQLTSMPSFWSLQAYYTRYF--VSNIYLSPR-YLGNSPYDIAL 138
           HC   D+ D +   VQ  +            YY      VS I + P+ Y      DIAL
Sbjct: 74  HCVGPDVKDLAALRVQLREQ---------HLYYQDQLLPVSRIIVHPQFYTAQIGADIAL 124

Query: 139 VKLSAPVTYTKHIQPICLQASTFEFENRTDCWVTGWGYIKEDEALPSPHTLQEVQVAIIN 198
           ++L  PV  + H+  + L  ++  F     CWVTGWG +  DE LP P  L++V+V I+ 
Sbjct: 125 LELEEPVNVSSHVHTVTLPPASETFPPGMPCWVTGWGDVDNDERLPPPFPLKQVKVPIME 184

Query: 199 NSMCNHLFLKYSFRKD----IFGDMVCAGNAQGGKDACFGDSGGPLACNKNGLWYQIGVV 254
           N +C+  +   ++  D    +  DM+CAGN +  +D+C GDSGGPL C  NG W Q GVV
Sbjct: 185 NHICDAKYHLGAYTGDDVRIVRDDMLCAGNTR--RDSCQGDSGGPLVCKVNGTWLQAGVV 242

Query: 255 SWGVGCGRPNRPGVYTNISHHFEWI 279
           SWG GC +PNRPG+YT ++++ +WI
Sbjct: 243 SWGEGCAQPNRPGIYTRVTYYLDWI 267


>gi|78191798 plasma kallikrein B1 precursor [Homo sapiens]
          Length = 638

 Score =  194 bits (492), Expect = 1e-49
 Identities = 102/257 (39%), Positives = 148/257 (57%), Gaps = 16/257 (6%)

Query: 39  TSRIVGGEDAELGRWPWQGSLRLW---DSHVCGVSLLSHRWALTAAHCFETDLSDPSGWM 95
           ++RIVGG ++  G WPWQ SL++      H+CG SL+ H+W LTAAHCF+  L     W 
Sbjct: 388 STRIVGGTNSSWGEWPWQVSLQVKLTAQRHLCGGSLIGHQWVLTAAHCFD-GLPLQDVWR 446

Query: 96  VQFGQLTSMPSFWSLQAYYTRYFVSNIYLSPRY-LGNSPYDIALVKLSAPVTYTKHIQPI 154
           +  G L    S  +    +++  +  I +   Y +    +DIAL+KL AP+ YT+  +PI
Sbjct: 447 IYSGILNL--SDITKDTPFSQ--IKEIIIHQNYKVSEGNHDIALIKLQAPLNYTEFQKPI 502

Query: 155 CLQASTFEFENRTDCWVTGWGYIKEDEALPSPHTLQEVQVAIINNSMCNHLFLKYSFRKD 214
           CL +        T+CWVTGWG+ KE   + +   LQ+V + ++ N  C   +  Y   + 
Sbjct: 503 CLPSKGDTSTIYTNCWVTGWGFSKEKGEIQN--ILQKVNIPLVTNEECQKRYQDYKITQR 560

Query: 215 IFGDMVCAGNAQGGKDACFGDSGGPLACNKNGLWYQIGVVSWGVGCGRPNRPGVYTNISH 274
               MVCAG  +GGKDAC GDSGGPL C  NG+W  +G+ SWG GC R  +PGVYT ++ 
Sbjct: 561 ----MVCAGYKEGGKDACKGDSGGPLVCKHNGMWRLVGITSWGEGCARREQPGVYTKVAE 616

Query: 275 HFEWI-QKLMAQSGMSQ 290
           + +WI +K  +  G +Q
Sbjct: 617 YMDWILEKTQSSDGKAQ 633


>gi|13173471 transmembrane protease, serine 3 isoform 1 [Homo
           sapiens]
          Length = 454

 Score =  192 bits (489), Expect = 2e-49
 Identities = 101/257 (39%), Positives = 146/257 (56%), Gaps = 21/257 (8%)

Query: 33  CG-RRVITSRIVGGEDAELGRWPWQGSLRLWDSHVCGVSLLSHRWALTAAHCFETDLSDP 91
           CG RR  +SRIVGG  + L +WPWQ SL+    H+CG S+++  W +TAAHC   DL  P
Sbjct: 207 CGHRRGYSSRIVGGNMSLLSQWPWQASLQFQGYHLCGGSVITPLWIITAAHCVY-DLYLP 265

Query: 92  SGWMVQFGQLTSMPSFWSLQAYYTRYFVSNIYLSPRYLGNSPYDIALVKLSAPVTYTKHI 151
             W +Q G ++ + +     ++     V +    P+ LGN   DIAL+KL+ P+T+ + I
Sbjct: 266 KSWTIQVGLVSLLDN--PAPSHLVEKIVYHSKYKPKRLGN---DIALMKLAGPLTFNEMI 320

Query: 152 QPICLQASTFEFENRTDCWVTGWGYIKEDEALPSPHTLQEVQVAIINNSMCNHLFLKYSF 211
           QP+CL  S   F +   CW +GWG  ++     SP  L    V +I+N +CNH       
Sbjct: 321 QPVCLPNSEENFPDGKVCWTSGWGATEDGAGDASP-VLNHAAVPLISNKICNH------- 372

Query: 212 RKDIFG-----DMVCAGNAQGGKDACFGDSGGPLACNKNGLWYQIGVVSWGVGCGRPNRP 266
            +D++G      M+CAG   GG D+C GDSGGPL C +  LW  +G  S+G+GC   N+P
Sbjct: 373 -RDVYGGIISPSMLCAGYLTGGVDSCQGDSGGPLVCQERRLWKLVGATSFGIGCAEVNKP 431

Query: 267 GVYTNISHHFEWIQKLM 283
           GVYT ++   +WI + M
Sbjct: 432 GVYTRVTSFLDWIHEQM 448


>gi|239753545 PREDICTED: similar to hCG2041452 [Homo sapiens]
          Length = 410

 Score =  191 bits (485), Expect = 7e-49
 Identities = 105/252 (41%), Positives = 134/252 (53%), Gaps = 13/252 (5%)

Query: 30  SGPCGRRVITSRIVGGEDAELGRWPWQGSLRLWDSHVCGVSLLSHRWALTAAHCFETDLS 89
           S  CG RV  SR++GG  A   +WPWQ SL+  + H CG SL+  RW LTAAHC      
Sbjct: 153 SQACGHRV--SRMIGGLPAPNKKWPWQVSLQTSNIHHCGGSLIDRRWVLTAAHCVFRGCG 210

Query: 90  DPSGWMVQFGQLTSMPSFWSLQAYYTRYFVSNIYLSPRYLGNSPYDIALVKLSAPVTYTK 149
              G  +  G +      W       ++    I+ S         DIAL  L+  V Y+ 
Sbjct: 211 WEGGRWLLAG-IGRWDQAW-------KHLEDIIFPSNFDFATLTSDIALALLAYSVNYSS 262

Query: 150 HIQPICLQASTFEFENRTDCWVTGWGYIKEDEALPSPHTLQEVQVAIINNSMCNHLFLKY 209
           HIQP CL    FE E  T+CWVTGWG + E  + P P  LQE ++ I+ +  C  +    
Sbjct: 263 HIQPACLPEKLFEVEAGTECWVTGWGQVSESVSGPMPLVLQETELNIMRHEKCCEMLKNK 322

Query: 210 SFRKD--IFGDMVCAGNAQGGKDACFGDSGGPLACNKNGLWYQIGVVSWGVGCGRPNRPG 267
           +  K   +    VC  N QG KDAC GDSGGPL C  NG W Q+G+VSWG+GCGR   PG
Sbjct: 323 NISKSKMVTRGTVCGYNDQG-KDACQGDSGGPLVCELNGTWVQVGIVSWGIGCGRKGYPG 381

Query: 268 VYTNISHHFEWI 279
           VYT +S + +WI
Sbjct: 382 VYTEVSFYKKWI 393


>gi|239748117 PREDICTED: hypothetical protein XP_002346556 [Homo
           sapiens]
          Length = 410

 Score =  191 bits (485), Expect = 7e-49
 Identities = 105/252 (41%), Positives = 134/252 (53%), Gaps = 13/252 (5%)

Query: 30  SGPCGRRVITSRIVGGEDAELGRWPWQGSLRLWDSHVCGVSLLSHRWALTAAHCFETDLS 89
           S  CG RV  SR++GG  A   +WPWQ SL+  + H CG SL+  RW LTAAHC      
Sbjct: 153 SQACGHRV--SRMIGGLPAPNKKWPWQVSLQTSNIHHCGGSLIDRRWVLTAAHCVFRGCG 210

Query: 90  DPSGWMVQFGQLTSMPSFWSLQAYYTRYFVSNIYLSPRYLGNSPYDIALVKLSAPVTYTK 149
              G  +  G +      W       ++    I+ S         DIAL  L+  V Y+ 
Sbjct: 211 WEGGRWLLAG-IGRWDQAW-------KHLEDIIFPSNFDFATLTSDIALALLAYSVNYSS 262

Query: 150 HIQPICLQASTFEFENRTDCWVTGWGYIKEDEALPSPHTLQEVQVAIINNSMCNHLFLKY 209
           HIQP CL    FE E  T+CWVTGWG + E  + P P  LQE ++ I+ +  C  +    
Sbjct: 263 HIQPACLPEKLFEVEAGTECWVTGWGQVSESVSGPMPLVLQETELNIMRHEKCCEMLKNK 322

Query: 210 SFRKD--IFGDMVCAGNAQGGKDACFGDSGGPLACNKNGLWYQIGVVSWGVGCGRPNRPG 267
           +  K   +    VC  N QG KDAC GDSGGPL C  NG W Q+G+VSWG+GCGR   PG
Sbjct: 323 NISKSKMVTRGTVCGYNDQG-KDACQGDSGGPLVCELNGTWVQVGIVSWGIGCGRKGYPG 381

Query: 268 VYTNISHHFEWI 279
           VYT +S + +WI
Sbjct: 382 VYTEVSFYKKWI 393


>gi|239742016 PREDICTED: hypothetical protein XP_002342392 [Homo
           sapiens]
          Length = 410

 Score =  191 bits (485), Expect = 7e-49
 Identities = 105/252 (41%), Positives = 134/252 (53%), Gaps = 13/252 (5%)

Query: 30  SGPCGRRVITSRIVGGEDAELGRWPWQGSLRLWDSHVCGVSLLSHRWALTAAHCFETDLS 89
           S  CG RV  SR++GG  A   +WPWQ SL+  + H CG SL+  RW LTAAHC      
Sbjct: 153 SQACGHRV--SRMIGGLPAPNKKWPWQVSLQTSNIHHCGGSLIDRRWVLTAAHCVFRGCG 210

Query: 90  DPSGWMVQFGQLTSMPSFWSLQAYYTRYFVSNIYLSPRYLGNSPYDIALVKLSAPVTYTK 149
              G  +  G +      W       ++    I+ S         DIAL  L+  V Y+ 
Sbjct: 211 WEGGRWLLAG-IGRWDQAW-------KHLEDIIFPSNFDFATLTSDIALALLAYSVNYSS 262

Query: 150 HIQPICLQASTFEFENRTDCWVTGWGYIKEDEALPSPHTLQEVQVAIINNSMCNHLFLKY 209
           HIQP CL    FE E  T+CWVTGWG + E  + P P  LQE ++ I+ +  C  +    
Sbjct: 263 HIQPACLPEKLFEVEAGTECWVTGWGQVSESVSGPMPLVLQETELNIMRHEKCCEMLKNK 322

Query: 210 SFRKD--IFGDMVCAGNAQGGKDACFGDSGGPLACNKNGLWYQIGVVSWGVGCGRPNRPG 267
           +  K   +    VC  N QG KDAC GDSGGPL C  NG W Q+G+VSWG+GCGR   PG
Sbjct: 323 NISKSKMVTRGTVCGYNDQG-KDACQGDSGGPLVCELNGTWVQVGIVSWGIGCGRKGYPG 381

Query: 268 VYTNISHHFEWI 279
           VYT +S + +WI
Sbjct: 382 VYTEVSFYKKWI 393


>gi|117956391 protease, serine, 33 [Homo sapiens]
          Length = 280

 Score =  189 bits (479), Expect = 4e-48
 Identities = 109/282 (38%), Positives = 156/282 (55%), Gaps = 23/282 (8%)

Query: 7   LLLALLLARAGLRKPESQEAAPLSGPCGRRVITSRIVGGEDAELGRWPWQGSLRLWDSHV 66
           +LL L+L  AG +  +S         CG+  ++SRIVGG D   G WPWQ S++   +HV
Sbjct: 9   VLLLLVLGAAGTQGRKS-------AACGQPRMSSRIVGGRDGRDGEWPWQASIQHRGAHV 61

Query: 67  CGVSLLSHRWALTAAHCFETDLSDPSGWMVQFGQL---TSMPSFWSLQAYYTRYFVSNIY 123
           CG SL++ +W LTAAHCF      P+ + V+ G L   ++ P   S+        V  + 
Sbjct: 62  CGGSLIAPQWVLTAAHCFPRRAL-PAEYRVRLGALRLGSTSPRTLSVP-------VRRVL 113

Query: 124 LSPRYLGNSPY-DIALVKLSAPVTYTKHIQPICLQASTFEFENRTDCWVTGWGYIKEDEA 182
           L P Y  +    D+AL++L  PV  +  +QP+CL          T C VTGWG ++    
Sbjct: 114 LPPDYSEDGARGDLALLQLRRPVPLSARVQPVCLPVPGARPPPGTPCRVTGWGSLRPGVP 173

Query: 183 LPSPHTLQEVQVAIINNSMCNHLFLKYS----FRKDIFGDMVCAGNAQGGKDACFGDSGG 238
           LP    LQ V+V ++++  C+ L+   +      + +    +CAG  QG KDAC GDSGG
Sbjct: 174 LPEWRPLQGVRVPLLDSRTCDGLYHVGADVPQAERIVLPGSLCAGYPQGHKDACQGDSGG 233

Query: 239 PLACNKNGLWYQIGVVSWGVGCGRPNRPGVYTNISHHFEWIQ 280
           PL C ++G W  +GVVSWG GC  PNRPGVYT+++ +  WIQ
Sbjct: 234 PLTCLQSGSWVLVGVVSWGKGCALPNRPGVYTSVATYSPWIQ 275


>gi|4758508 transmembrane protease, serine 11D [Homo sapiens]
          Length = 418

 Score =  188 bits (478), Expect = 5e-48
 Identities = 106/254 (41%), Positives = 149/254 (58%), Gaps = 16/254 (6%)

Query: 30  SGPCGRRVITSRIVGGEDAELGRWPWQGSLRLWDSHVCGVSLLSHRWALTAAHCFETDLS 89
           +GP    +   RI+GG +AE G WPWQ SLRL ++H CG SL+++ W LTAAHCF ++ S
Sbjct: 175 AGPDLITLSEQRILGGTEAEEGSWPWQVSLRLNNAHHCGGSLINNMWILTAAHCFRSN-S 233

Query: 90  DPSGWMVQFGQLTSMPSFWSLQAYYTRYFVSNIYLSPRY-LGNSPYDIALVKLSAPVTYT 148
           +P  W+   G  T+ P          R  V NI +   Y       DIALV+L   VT+T
Sbjct: 234 NPRDWIATSGISTTFPKL--------RMRVRNILIHNNYKSATHENDIALVRLENSVTFT 285

Query: 149 KHIQPICLQASTFEFENRTDCWVTGWGYIKEDEALPSPHTLQEVQVAIINNSMCNHLFLK 208
           K I  +CL A+T      +  +VTGWG   ++ A  +   L++ QV II+N +CN     
Sbjct: 286 KDIHSVCLPAATQNIPPGSTAYVTGWG--AQEYAGHTVPELRQGQVRIISNDVCN---AP 340

Query: 209 YSFRKDIFGDMVCAGNAQGGKDACFGDSGGPLAC-NKNGLWYQIGVVSWGVGCGRPNRPG 267
           +S+   I   M+CAG  QGG DAC GDSGGPL   +   LW+ +G+VSWG  CG P++PG
Sbjct: 341 HSYNGAILSGMLCAGVPQGGVDACQGDSGGPLVQEDSRRLWFIVGIVSWGDQCGLPDKPG 400

Query: 268 VYTNISHHFEWIQK 281
           VYT ++ + +WI++
Sbjct: 401 VYTRVTAYLDWIRQ 414


>gi|33667063 transmembrane protease, serine 9 [Homo sapiens]
          Length = 1059

 Score =  184 bits (467), Expect = 9e-47
 Identities = 97/271 (35%), Positives = 150/271 (55%), Gaps = 23/271 (8%)

Query: 38  ITSRIVGGEDAELGRWPWQGSLRLWDSHVCGVSLLSHRWALTAAHCFETDLSDPSGWMVQ 97
           +  RIVGG +A  G +PWQ SLR    H CG ++++ RW ++AAHCF  +  DP+ W+  
Sbjct: 199 MAGRIVGGMEASPGEFPWQASLRENKEHFCGAAIINARWLVSAAHCFN-EFQDPTKWVAY 257

Query: 98  FGQLTSMPSFWSLQAYYTRYFVSNIYLSPRYLGNSP-YDIALVKLSAPVTYTKHIQPICL 156
            G      S    +A   R  V  I   P Y  ++  +D+A+++L++P+ + +HIQP+CL
Sbjct: 258 VGATYLSGS----EASTVRAQVVQIVKHPLYNADTADFDVAVLELTSPLPFGRHIQPVCL 313

Query: 157 QASTFEFENRTDCWVTGWGYIKEDEALPSPHTLQEVQVAIINNSMCNHLFLKYSFRKDIF 216
            A+T  F     C ++GWGY+KED  L  P  LQ+  V +++ ++C  L     +   + 
Sbjct: 314 PAATHIFPPSKKCLISGWGYLKED-FLVKPEVLQKATVELLDQALCASL-----YGHSLT 367

Query: 217 GDMVCAGNAQGGKDACFGDSGGPLACNK-NGLWYQIGVVSWGVGCGRPNRPGVYTNISHH 275
             MVCAG   G  D+C GDSGGPL C + +G ++  G+VSWG+GC    RPGVY  ++  
Sbjct: 368 DRMVCAGYLDGKVDSCQGDSGGPLVCEEPSGRFFLAGIVSWGIGCAEARRPGVYARVTRL 427

Query: 276 FEWIQKLMAQSGM----------SQPDPSWP 296
            +WI +   ++ M          + P  +WP
Sbjct: 428 RDWILEATTKASMPLAPTMAPAPAAPSTAWP 458



 Score =  166 bits (421), Expect = 2e-41
 Identities = 97/243 (39%), Positives = 131/243 (53%), Gaps = 17/243 (6%)

Query: 40   SRIVGGEDAELGRWPWQGSLRLWD-SHVCGVSLLSHRWALTAAHCFETDLSDPSGWMVQF 98
            +RIVGG  A  G WPWQ SL L    H CG  L++ RW L+AAHCF+    DP  W    
Sbjct: 825  TRIVGGSAAGRGEWPWQVSLWLRRREHRCGAVLVAERWLLSAAHCFDV-YGDPKQWAAFL 883

Query: 99   GQLTSMPSFWSLQAYYTRYFVSNIYLSPRY-LGNSPYDIALVKLSAPVTYTKHIQPICLQ 157
            G     P     +    R  V+ IY  P Y L    YD+AL++L+ PV  ++ ++PICL 
Sbjct: 884  GT----PFLSGAEGQLER--VARIYKHPFYNLYTLDYDVALLELAGPVRRSRLVRPICLP 937

Query: 158  ASTFEFENRTDCWVTGWGYIKEDEALPSPHTLQEVQVAIINNSMCNHLFLKYSFRKDIFG 217
                   + T C +TGWG ++E  ++     LQ+  V +++   C   +        I  
Sbjct: 938  EPAPRPPDGTRCVITGWGSVREGGSMA--RQLQKAAVRLLSEQTCRRFY-----PVQISS 990

Query: 218  DMVCAGNAQGGKDACFGDSGGPLACNK-NGLWYQIGVVSWGVGCGRPNRPGVYTNISHHF 276
             M+CAG  QGG D+C GD+GGPLAC + +G W   GV SWG GCGRP+ PGVYT ++   
Sbjct: 991  RMLCAGFPQGGVDSCSGDAGGPLACREPSGRWVLTGVTSWGYGCGRPHFPGVYTRVAAVR 1050

Query: 277  EWI 279
             WI
Sbjct: 1051 GWI 1053



 Score =  164 bits (416), Expect = 7e-41
 Identities = 95/267 (35%), Positives = 142/267 (53%), Gaps = 17/267 (6%)

Query: 33  CGRRVIT---SRIVGGEDAELGRWPWQGSLRLWDSHVCGVSLLSHRWALTAAHCFETDLS 89
           CG R      +R+VGG  A  G  PWQ SL+    H CG +++  RW L+AAHCF     
Sbjct: 492 CGARPAMEKPTRVVGGFGAASGEVPWQVSLKEGSRHFCGATVVGDRWLLSAAHCFNHTKV 551

Query: 90  DPSGWMVQFGQLTSMPSFWSLQAYYTRYFVSNIYLSPRY-LGNSPYDIALVKLSAPVTYT 148
           +      Q        S   L     +  +  + L P Y  G   +D+A+++L++P+ + 
Sbjct: 552 E------QVRAHLGTASLLGLGGSPVKIGLRRVVLHPLYNPGILDFDLAVLELASPLAFN 605

Query: 149 KHIQPICLQASTFEFENRTDCWVTGWGYIKEDEALPSPHTLQEVQVAIINNSMCNHLFLK 208
           K+IQP+CL  +  +F     C ++GWG  +E  A   P  LQ+  V II+   C+ L   
Sbjct: 606 KYIQPVCLPLAIQKFPVGRKCMISGWGNTQEGNA-TKPELLQKASVGIIDQKTCSVL--- 661

Query: 209 YSFRKDIFGDMVCAGNAQGGKDACFGDSGGPLACNK-NGLWYQIGVVSWGVGCGRPNRPG 267
           Y+F   +   M+CAG  +G  D+C GDSGGPLAC +  G++Y  G+VSWG+GC +  +PG
Sbjct: 662 YNF--SLTDRMICAGFLEGKVDSCQGDSGGPLACEEAPGVFYLAGIVSWGIGCAQVKKPG 719

Query: 268 VYTNISHHFEWIQKLMAQSGMSQPDPS 294
           VYT I+    WI ++M+   +    PS
Sbjct: 720 VYTRITRLKGWILEIMSSQPLPMSPPS 746


>gi|4503627 coagulation factor XI precursor [Homo sapiens]
          Length = 625

 Score =  182 bits (463), Expect = 3e-46
 Identities = 98/246 (39%), Positives = 137/246 (55%), Gaps = 15/246 (6%)

Query: 38  ITSRIVGGEDAELGRWPWQGSLRLWDS---HVCGVSLLSHRWALTAAHCFETDLSDPSGW 94
           I  RIVGG  +  G WPWQ +L        H+CG S++ ++W LTAAHCF   +  P   
Sbjct: 384 IKPRIVGGTASVRGEWPWQVTLHTTSPTQRHLCGGSIIGNQWILTAAHCFY-GVESPKIL 442

Query: 95  MVQFGQLTSMPSFWSLQAYYTRYFVSNIYLSPRY-LGNSPYDIALVKLSAPVTYTKHIQP 153
            V  G L        ++   + + V  I +  +Y +  S YDIAL+KL   V YT   +P
Sbjct: 443 RVYSGILNQS----EIKEDTSFFGVQEIIIHDQYKMAESGYDIALLKLETTVNYTDSQRP 498

Query: 154 ICLQASTFEFENRTDCWVTGWGYIKEDEALPSPHTLQEVQVAIINNSMCNHLFLKYSFRK 213
           ICL +        TDCWVTGWGY K  + + +  TLQ+ ++ ++ N  C   +  +    
Sbjct: 499 ICLPSKGDRNVIYTDCWVTGWGYRKLRDKIQN--TLQKAKIPLVTNEECQKRYRGHK--- 553

Query: 214 DIFGDMVCAGNAQGGKDACFGDSGGPLACNKNGLWYQIGVVSWGVGCGRPNRPGVYTNIS 273
            I   M+CAG  +GGKDAC GDSGGPL+C  N +W+ +G+ SWG GC +  RPGVYTN+ 
Sbjct: 554 -ITHKMICAGYREGGKDACKGDSGGPLSCKHNEVWHLVGITSWGEGCAQRERPGVYTNVV 612

Query: 274 HHFEWI 279
            + +WI
Sbjct: 613 EYVDWI 618


>gi|227499990 transmembrane protease, serine 2 isoform 1 [Homo
           sapiens]
          Length = 529

 Score =  181 bits (460), Expect = 6e-46
 Identities = 97/249 (38%), Positives = 131/249 (52%), Gaps = 11/249 (4%)

Query: 40  SRIVGGEDAELGRWPWQGSLRLWDSHVCGVSLLSHRWALTAAHCFETDLSDPSGWMVQFG 99
           SRIVGGE A  G WPWQ SL + + HVCG S+++  W +TAAHC E  L++P  W    G
Sbjct: 291 SRIVGGESALPGAWPWQVSLHVQNVHVCGGSIITPEWIVTAAHCVEKPLNNPWHWTAFAG 350

Query: 100 QLTSMPSFWSLQAYYTRYFVSNIYLSPRYLGNSPY-DIALVKLSAPVTYTKHIQPICLQA 158
            L       S   Y   Y V  +   P Y   +   DIAL+KL  P+T+   ++P+CL  
Sbjct: 351 ILRQ-----SFMFYGAGYQVEKVISHPNYDSKTKNNDIALMKLQKPLTFNDLVKPVCLPN 405

Query: 159 STFEFENRTDCWVTGWGYIKEDEALPSPHTLQEVQVAIINNSMCNHLFLKYSFRKDIFGD 218
                +    CW++GWG  +E     +   L   +V +I    CN    +Y +   I   
Sbjct: 406 PGMMLQPEQLCWISGWGATEEKGK--TSEVLNAAKVLLIETQRCNS---RYVYDNLITPA 460

Query: 219 MVCAGNAQGGKDACFGDSGGPLACNKNGLWYQIGVVSWGVGCGRPNRPGVYTNISHHFEW 278
           M+CAG  QG  D+C GDSGGPL  +KN +W+ IG  SWG GC +  RPGVY N+    +W
Sbjct: 461 MICAGFLQGNVDSCQGDSGGPLVTSKNNIWWLIGDTSWGSGCAKAYRPGVYGNVMVFTDW 520

Query: 279 IQKLMAQSG 287
           I + M   G
Sbjct: 521 IYRQMRADG 529


>gi|205360943 transmembrane protease, serine 2 isoform 2 [Homo
           sapiens]
          Length = 492

 Score =  181 bits (460), Expect = 6e-46
 Identities = 97/249 (38%), Positives = 131/249 (52%), Gaps = 11/249 (4%)

Query: 40  SRIVGGEDAELGRWPWQGSLRLWDSHVCGVSLLSHRWALTAAHCFETDLSDPSGWMVQFG 99
           SRIVGGE A  G WPWQ SL + + HVCG S+++  W +TAAHC E  L++P  W    G
Sbjct: 254 SRIVGGESALPGAWPWQVSLHVQNVHVCGGSIITPEWIVTAAHCVEKPLNNPWHWTAFAG 313

Query: 100 QLTSMPSFWSLQAYYTRYFVSNIYLSPRYLGNSPY-DIALVKLSAPVTYTKHIQPICLQA 158
            L       S   Y   Y V  +   P Y   +   DIAL+KL  P+T+   ++P+CL  
Sbjct: 314 ILRQ-----SFMFYGAGYQVEKVISHPNYDSKTKNNDIALMKLQKPLTFNDLVKPVCLPN 368

Query: 159 STFEFENRTDCWVTGWGYIKEDEALPSPHTLQEVQVAIINNSMCNHLFLKYSFRKDIFGD 218
                +    CW++GWG  +E     +   L   +V +I    CN    +Y +   I   
Sbjct: 369 PGMMLQPEQLCWISGWGATEEKGK--TSEVLNAAKVLLIETQRCNS---RYVYDNLITPA 423

Query: 219 MVCAGNAQGGKDACFGDSGGPLACNKNGLWYQIGVVSWGVGCGRPNRPGVYTNISHHFEW 278
           M+CAG  QG  D+C GDSGGPL  +KN +W+ IG  SWG GC +  RPGVY N+    +W
Sbjct: 424 MICAGFLQGNVDSCQGDSGGPLVTSKNNIWWLIGDTSWGSGCAKAYRPGVYGNVMVFTDW 483

Query: 279 IQKLMAQSG 287
           I + M   G
Sbjct: 484 IYRQMRADG 492


>gi|145701030 transmembrane protease, serine 4 isoform 3 [Homo
           sapiens]
          Length = 432

 Score =  180 bits (456), Expect = 2e-45
 Identities = 98/249 (39%), Positives = 143/249 (57%), Gaps = 17/249 (6%)

Query: 33  CGRRVITSRIVGGEDAELGRWPWQGSLRLWDSHVCGVSLLSHRWALTAAHCFETDLSDPS 92
           CG+ + T R+VGGE+A +  WPWQ S++    HVCG S+L   W LTAAHCF    +D  
Sbjct: 191 CGKSLKTPRVVGGEEASVDSWPWQVSIQYDKQHVCGGSILDPHWVLTAAHCFRKH-TDVF 249

Query: 93  GWMVQFG--QLTSMPSFWSLQAYYTRYFVSNIYLSPRYLGNSPYDIALVKLSAPVTYTKH 150
            W V+ G  +L S PS    +       +  I  +P Y  ++  DIAL+KL  P+T++  
Sbjct: 250 NWKVRAGSDKLGSFPSLAVAK-------IIIIEFNPMYPKDN--DIALMKLQFPLTFSGT 300

Query: 151 IQPICLQASTFEFENRTDCWVTGWGYIKEDEALPSPHTLQEVQVAIINNSMCNHLFLKYS 210
           ++PICL     E    T  W+ GWG+ K++    S   LQ   V +I+++ CN      +
Sbjct: 301 VRPICLPFFDEELTPATPLWIIGWGFTKQNGGKMSDILLQ-ASVQVIDSTRCN---ADDA 356

Query: 211 FRKDIFGDMVCAGNAQGGKDACFGDSGGPLACNKNGLWYQIGVVSWGVGCGRPNRPGVYT 270
           ++ ++   M+CAG  +GG D C GDSGGPL   ++  W+ +G+VSWG GCG P+ PGVYT
Sbjct: 357 YQGEVTEKMMCAGIPEGGVDTCQGDSGGPL-MYQSDQWHVVGIVSWGYGCGGPSTPGVYT 415

Query: 271 NISHHFEWI 279
            +S +  WI
Sbjct: 416 KVSAYLNWI 424


>gi|15451940 transmembrane protease, serine 4 isoform 1 [Homo
           sapiens]
          Length = 437

 Score =  180 bits (456), Expect = 2e-45
 Identities = 98/249 (39%), Positives = 143/249 (57%), Gaps = 17/249 (6%)

Query: 33  CGRRVITSRIVGGEDAELGRWPWQGSLRLWDSHVCGVSLLSHRWALTAAHCFETDLSDPS 92
           CG+ + T R+VGGE+A +  WPWQ S++    HVCG S+L   W LTAAHCF    +D  
Sbjct: 196 CGKSLKTPRVVGGEEASVDSWPWQVSIQYDKQHVCGGSILDPHWVLTAAHCFRKH-TDVF 254

Query: 93  GWMVQFG--QLTSMPSFWSLQAYYTRYFVSNIYLSPRYLGNSPYDIALVKLSAPVTYTKH 150
            W V+ G  +L S PS    +       +  I  +P Y  ++  DIAL+KL  P+T++  
Sbjct: 255 NWKVRAGSDKLGSFPSLAVAK-------IIIIEFNPMYPKDN--DIALMKLQFPLTFSGT 305

Query: 151 IQPICLQASTFEFENRTDCWVTGWGYIKEDEALPSPHTLQEVQVAIINNSMCNHLFLKYS 210
           ++PICL     E    T  W+ GWG+ K++    S   LQ   V +I+++ CN      +
Sbjct: 306 VRPICLPFFDEELTPATPLWIIGWGFTKQNGGKMSDILLQ-ASVQVIDSTRCN---ADDA 361

Query: 211 FRKDIFGDMVCAGNAQGGKDACFGDSGGPLACNKNGLWYQIGVVSWGVGCGRPNRPGVYT 270
           ++ ++   M+CAG  +GG D C GDSGGPL   ++  W+ +G+VSWG GCG P+ PGVYT
Sbjct: 362 YQGEVTEKMMCAGIPEGGVDTCQGDSGGPL-MYQSDQWHVVGIVSWGYGCGGPSTPGVYT 420

Query: 271 NISHHFEWI 279
            +S +  WI
Sbjct: 421 KVSAYLNWI 429


>gi|33186882 testis serine protease 2 [Homo sapiens]
          Length = 293

 Score =  180 bits (456), Expect = 2e-45
 Identities = 108/267 (40%), Positives = 142/267 (53%), Gaps = 26/267 (9%)

Query: 12  LLARAGLRKPESQEA-APLSGP--------------CGRRVITSRIVGGEDAELGRWPWQ 56
           LL+  G   PE+  A  P +GP              CGR  +  RIVGG DAE GRWPWQ
Sbjct: 37  LLSEEGGENPEASPAPGPEAGPPLNLFTSFPGDSLLCGRTPL--RIVGGVDAEEGRWPWQ 94

Query: 57  GSLRLWDSHVCGVSLLSHRWALTAAHCFETDLSDPSGWMVQFGQLTSMPSFWSLQAYYTR 116
            S+R    H+CG +L++  W LTA HC    +S    + V+ G  +      S+     R
Sbjct: 95  VSVRTKGRHICGGTLVTATWVLTAGHC----ISSRFHYSVKMGDRSVYNENTSVVVSVQR 150

Query: 117 YFVSNIYLSPRYLGNSPYDIALVKLSAPVTYTKHIQPICLQASTFEFENRTDCWVTGWGY 176
            FV   + +   + N   D+AL++L  PV +T +IQPIC+    F+ E RT CWVTGWG 
Sbjct: 151 AFVHPKFSTVTTIRN---DLALLQLQHPVNFTSNIQPICIPQENFQVEGRTRCWVTGWGK 207

Query: 177 IKEDEALPSPHTLQEVQVAIINNSMCNHLFLK-YSFRKDIFGDMVCAGNAQGGKDACFGD 235
             E E L S   LQ+V   I+    CN +  K  S  KD+    +  G  + GKD+C GD
Sbjct: 208 TPEREKLAS-EILQDVDQYIMCYEECNKIIQKALSSTKDVIIKGMVCGYKEQGKDSCQGD 266

Query: 236 SGGPLACNKNGLWYQIGVVSWGVGCGR 262
           SGG LAC  N  W Q+G+VSWG+GCGR
Sbjct: 267 SGGRLACEYNDTWVQVGIVSWGIGCGR 293


>gi|33695155 hepsin [Homo sapiens]
          Length = 417

 Score =  179 bits (455), Expect = 2e-45
 Identities = 114/270 (42%), Positives = 139/270 (51%), Gaps = 21/270 (7%)

Query: 21  PESQEAAPLSGPCGRRVI-TSRIVGGEDAELGRWPWQGSLRLWDSHVCGVSLLSHRWALT 79
           P  +  A +   CGRR +   RIVGG D  LGRWPWQ SLR   +H+CG SLLS  W LT
Sbjct: 141 PRGRFLAAICQDCGRRKLPVDRIVGGRDTSLGRWPWQVSLRYDGAHLCGGSLLSGDWVLT 200

Query: 80  AAHCFETDLSDPSGWMVQFGQLTSMPSFWSLQAYYTRYFVSNIYL---SPRYLGNSPYDI 136
           AAHCF       S W V F    +  S   LQ           YL    P    NS  DI
Sbjct: 201 AAHCFPERNRVLSRWRV-FAGAVAQASPHGLQLGVQAVVYHGGYLPFRDPNSEENS-NDI 258

Query: 137 ALVKLSAPVTYTKHIQPICLQASTFEFENRTDCWVTGWG---YIKEDEALPSPHTLQEVQ 193
           ALV LS+P+  T++IQP+CL A+     +   C VTGWG   Y  +   +     LQE +
Sbjct: 259 ALVHLSSPLPLTEYIQPVCLPAAGQALVDGKICTVTGWGNTQYYGQQAGV-----LQEAR 313

Query: 194 VAIINNSMCNHLFLKYSFRKDIFGDMVCAGNAQGGKDACFGDSGGPLAC----NKNGLWY 249
           V II+N +CN       +   I   M CAG  +GG DAC GDSGGP  C    ++   W 
Sbjct: 314 VPIISNDVCNGADF---YGNQIKPKMFCAGYPEGGIDACQGDSGGPFVCEDSISRTPRWR 370

Query: 250 QIGVVSWGVGCGRPNRPGVYTNISHHFEWI 279
             G+VSWG GC    +PGVYT +S   EWI
Sbjct: 371 LCGIVSWGTGCALAQKPGVYTKVSDFREWI 400


>gi|4504481 hepsin [Homo sapiens]
          Length = 417

 Score =  179 bits (455), Expect = 2e-45
 Identities = 114/270 (42%), Positives = 139/270 (51%), Gaps = 21/270 (7%)

Query: 21  PESQEAAPLSGPCGRRVI-TSRIVGGEDAELGRWPWQGSLRLWDSHVCGVSLLSHRWALT 79
           P  +  A +   CGRR +   RIVGG D  LGRWPWQ SLR   +H+CG SLLS  W LT
Sbjct: 141 PRGRFLAAICQDCGRRKLPVDRIVGGRDTSLGRWPWQVSLRYDGAHLCGGSLLSGDWVLT 200

Query: 80  AAHCFETDLSDPSGWMVQFGQLTSMPSFWSLQAYYTRYFVSNIYL---SPRYLGNSPYDI 136
           AAHCF       S W V F    +  S   LQ           YL    P    NS  DI
Sbjct: 201 AAHCFPERNRVLSRWRV-FAGAVAQASPHGLQLGVQAVVYHGGYLPFRDPNSEENS-NDI 258

Query: 137 ALVKLSAPVTYTKHIQPICLQASTFEFENRTDCWVTGWG---YIKEDEALPSPHTLQEVQ 193
           ALV LS+P+  T++IQP+CL A+     +   C VTGWG   Y  +   +     LQE +
Sbjct: 259 ALVHLSSPLPLTEYIQPVCLPAAGQALVDGKICTVTGWGNTQYYGQQAGV-----LQEAR 313

Query: 194 VAIINNSMCNHLFLKYSFRKDIFGDMVCAGNAQGGKDACFGDSGGPLAC----NKNGLWY 249
           V II+N +CN       +   I   M CAG  +GG DAC GDSGGP  C    ++   W 
Sbjct: 314 VPIISNDVCNGADF---YGNQIKPKMFCAGYPEGGIDACQGDSGGPFVCEDSISRTPRWR 370

Query: 250 QIGVVSWGVGCGRPNRPGVYTNISHHFEWI 279
             G+VSWG GC    +PGVYT +S   EWI
Sbjct: 371 LCGIVSWGTGCALAQKPGVYTKVSDFREWI 400


  Database: hs.faa
    Posted date:  Aug 4, 2009  4:42 PM
  Number of letters in database: 18,247,518
  Number of sequences in database:  37,866
  
Lambda     K      H
   0.322    0.138    0.468 

Gapped
Lambda     K      H
   0.267   0.0410    0.140 


Matrix: BLOSUM62
Gap Penalties: Existence: 11, Extension: 1
Number of Hits to DB: 13,474,580
Number of Sequences: 37866
Number of extensions: 635416
Number of successful extensions: 1883
Number of sequences better than 10.0: 30
Number of HSP's better than 10.0 without gapping: 164
Number of HSP's successfully gapped in prelim test: 7
Number of HSP's that attempted gapping in prelim test: 1240
Number of HSP's gapped (non-prelim): 203
length of query: 312
length of database: 18,247,518
effective HSP length: 102
effective length of query: 210
effective length of database: 14,385,186
effective search space: 3020889060
effective search space used: 3020889060
T: 11
A: 40
X1: 16 ( 7.4 bits)
X2: 38 (14.6 bits)
X3: 64 (24.7 bits)
S1: 41 (21.9 bits)
S2: 62 (28.5 bits)
Search results were obtained with NCBI BLAST and RefSeq entries.