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Search of human proteins with 21361682
BLASTP 2.2.11 [Jun-05-2005]
Reference: Altschul, Stephen F., Thomas L. Madden, Alejandro A. Schaffer,
Jinghui Zhang, Zheng Zhang, Webb Miller, and David J. Lipman (1997),
"Gapped BLAST and PSI-BLAST: a new generation of protein database search
programs", Nucleic Acids Res. 25:3389-3402.
Query= gi|21361682 Tax1 (human T-cell leukemia virus type I) binding
protein 1 isoform a [Homo sapiens]
(789 letters)
Database: hs.faa
37,866 sequences; 18,247,518 total letters
Searching..................................................done
Score E
Sequences producing significant alignments: (bits) Value
gi|21361682 Tax1 (human T-cell leukemia virus type I) binding pr... 1602 0.0
gi|119943086 Tax1 (human T-cell leukemia virus type I) binding p... 1494 0.0
gi|14149742 coiled-coil transcriptional coactivator isoform 1 [H... 275 2e-73
gi|219521893 coiled-coil transcriptional coactivator isoform 2 [... 184 3e-46
gi|5031937 calcium binding and coiled-coil domain 2 [Homo sapiens] 160 4e-39
gi|55770834 centromere protein F [Homo sapiens] 94 5e-19
gi|22538387 A-kinase anchor protein 9 isoform 2 [Homo sapiens] 91 4e-18
gi|22538393 A-kinase anchor protein 9 isoform 3 [Homo sapiens] 91 4e-18
gi|34878904 synaptonemal complex protein 1 [Homo sapiens] 89 2e-17
gi|56550047 uveal autoantigen with coiled-coil domains and ankyr... 88 3e-17
gi|59850762 uveal autoantigen with coiled-coil domains and ankyr... 88 3e-17
gi|71061468 centromere protein E [Homo sapiens] 86 1e-16
gi|148596984 golgi autoantigen, golgin subfamily b, macrogolgin ... 86 1e-16
gi|110611903 myosin, heavy polypeptide 4, skeletal muscle [Homo ... 84 4e-16
gi|6715600 golgi autoantigen, golgin subfamily a, 4 [Homo sapiens] 84 7e-16
gi|64085252 hypothetical protein LOC145508 [Homo sapiens] 84 7e-16
gi|12667788 myosin, heavy polypeptide 9, non-muscle [Homo sapiens] 83 1e-15
gi|98986453 myosin, heavy chain 3, skeletal muscle, embryonic [H... 83 1e-15
gi|110624781 myosin, heavy polypeptide 13, skeletal muscle [Homo... 83 1e-15
gi|56961680 coiled-coil domain containing 147 [Homo sapiens] 82 2e-15
gi|153945790 myosin, heavy chain 8, skeletal muscle, perinatal [... 81 3e-15
gi|38045898 RAB6-interacting protein 2 isoform epsilon [Homo sap... 80 6e-15
gi|58530840 desmoplakin isoform I [Homo sapiens] 80 1e-14
gi|41872583 Rho-associated, coiled-coil containing protein kinas... 79 1e-14
gi|153791586 myosin, heavy chain 2, skeletal muscle, adult [Homo... 79 1e-14
gi|153792663 myosin, heavy chain 2, skeletal muscle, adult [Homo... 79 1e-14
gi|115527082 myosin, heavy chain 1, skeletal muscle, adult [Homo... 79 2e-14
gi|156104908 myosin heavy chain 6 [Homo sapiens] 79 2e-14
gi|62243484 sarcoma antigen NY-SAR-41 [Homo sapiens] 79 2e-14
gi|38045896 RAB6-interacting protein 2 isoform delta [Homo sapiens] 78 3e-14
>gi|21361682 Tax1 (human T-cell leukemia virus type I) binding
protein 1 isoform a [Homo sapiens]
Length = 789
Score = 1602 bits (4147), Expect = 0.0
Identities = 789/789 (100%), Positives = 789/789 (100%)
Query: 1 MTSFQEVPLQTSNFAHVIFQNVAKSYLPNAHLECHYTLTPYIHPHPKDWVGIFKVGWSTA 60
MTSFQEVPLQTSNFAHVIFQNVAKSYLPNAHLECHYTLTPYIHPHPKDWVGIFKVGWSTA
Sbjct: 1 MTSFQEVPLQTSNFAHVIFQNVAKSYLPNAHLECHYTLTPYIHPHPKDWVGIFKVGWSTA 60
Query: 61 RDYYTFLWSPMPEHYVEGSTVNCVLAFQGYYLPNDDGEFYQFCYVTHKGEIRGASTPFQF 120
RDYYTFLWSPMPEHYVEGSTVNCVLAFQGYYLPNDDGEFYQFCYVTHKGEIRGASTPFQF
Sbjct: 61 RDYYTFLWSPMPEHYVEGSTVNCVLAFQGYYLPNDDGEFYQFCYVTHKGEIRGASTPFQF 120
Query: 121 RASSPVEELLTMEDEGNSDMLVVTTKAGLLELKIEKTMKEKEELLKLIAVLEKETAQLRE 180
RASSPVEELLTMEDEGNSDMLVVTTKAGLLELKIEKTMKEKEELLKLIAVLEKETAQLRE
Sbjct: 121 RASSPVEELLTMEDEGNSDMLVVTTKAGLLELKIEKTMKEKEELLKLIAVLEKETAQLRE 180
Query: 181 QVGRMERELNHEKERCDQLQAEQKGLTEVTQSLKMENEEFKKRFSDATSKAHQLEEDIVS 240
QVGRMERELNHEKERCDQLQAEQKGLTEVTQSLKMENEEFKKRFSDATSKAHQLEEDIVS
Sbjct: 181 QVGRMERELNHEKERCDQLQAEQKGLTEVTQSLKMENEEFKKRFSDATSKAHQLEEDIVS 240
Query: 241 VTHKAIEKETELDSLKDKLKKAQHEREQLECQLKTEKDEKELYKVHLKNTEIENTKLMSE 300
VTHKAIEKETELDSLKDKLKKAQHEREQLECQLKTEKDEKELYKVHLKNTEIENTKLMSE
Sbjct: 241 VTHKAIEKETELDSLKDKLKKAQHEREQLECQLKTEKDEKELYKVHLKNTEIENTKLMSE 300
Query: 301 VQTLKNLDGNKESVITHFKEEIGRLQLCLAEKENLQRTFLLTTSSKEDTCFLKEQLRKAE 360
VQTLKNLDGNKESVITHFKEEIGRLQLCLAEKENLQRTFLLTTSSKEDTCFLKEQLRKAE
Sbjct: 301 VQTLKNLDGNKESVITHFKEEIGRLQLCLAEKENLQRTFLLTTSSKEDTCFLKEQLRKAE 360
Query: 361 EQVQATRQEVVFLAKELSDAVNVRDRTMADLHTARLENEKVKKQLADAVAELKLNAMKKD 420
EQVQATRQEVVFLAKELSDAVNVRDRTMADLHTARLENEKVKKQLADAVAELKLNAMKKD
Sbjct: 361 EQVQATRQEVVFLAKELSDAVNVRDRTMADLHTARLENEKVKKQLADAVAELKLNAMKKD 420
Query: 421 QDKTDTLEHELRREVEDLKLRLQMAADHYKEKFKECQRLQKQINKLSDQSANNNNVFTKK 480
QDKTDTLEHELRREVEDLKLRLQMAADHYKEKFKECQRLQKQINKLSDQSANNNNVFTKK
Sbjct: 421 QDKTDTLEHELRREVEDLKLRLQMAADHYKEKFKECQRLQKQINKLSDQSANNNNVFTKK 480
Query: 481 TGNQQKVNDASVNTDPATSASTVDVKPSPSAAEADFDIVTKGQVCEMTKEIADKTEKYNK 540
TGNQQKVNDASVNTDPATSASTVDVKPSPSAAEADFDIVTKGQVCEMTKEIADKTEKYNK
Sbjct: 481 TGNQQKVNDASVNTDPATSASTVDVKPSPSAAEADFDIVTKGQVCEMTKEIADKTEKYNK 540
Query: 541 CKQLLQDEKAKCNKYADELAKMELKWKEQVKIAENVKLELAEVQDNYKELKRSLENPAER 600
CKQLLQDEKAKCNKYADELAKMELKWKEQVKIAENVKLELAEVQDNYKELKRSLENPAER
Sbjct: 541 CKQLLQDEKAKCNKYADELAKMELKWKEQVKIAENVKLELAEVQDNYKELKRSLENPAER 600
Query: 601 KMEGQNSQSPQCFKTCSEQNGYVLTLSNAQPVLQYGNPYASQETRDGADGAFYPDEIQRP 660
KMEGQNSQSPQCFKTCSEQNGYVLTLSNAQPVLQYGNPYASQETRDGADGAFYPDEIQRP
Sbjct: 601 KMEGQNSQSPQCFKTCSEQNGYVLTLSNAQPVLQYGNPYASQETRDGADGAFYPDEIQRP 660
Query: 661 PVRVPSWGLEDNVVCSQPARNFSRPDGLEDSEDSKEDENVPTAPDPPSQHLRGHGTGFCF 720
PVRVPSWGLEDNVVCSQPARNFSRPDGLEDSEDSKEDENVPTAPDPPSQHLRGHGTGFCF
Sbjct: 661 PVRVPSWGLEDNVVCSQPARNFSRPDGLEDSEDSKEDENVPTAPDPPSQHLRGHGTGFCF 720
Query: 721 DSSFDVHKKCPLCELMFPPNYDQSKFEEHVESHWKVCPMCSEQFPPDYDQQVFERHVQTH 780
DSSFDVHKKCPLCELMFPPNYDQSKFEEHVESHWKVCPMCSEQFPPDYDQQVFERHVQTH
Sbjct: 721 DSSFDVHKKCPLCELMFPPNYDQSKFEEHVESHWKVCPMCSEQFPPDYDQQVFERHVQTH 780
Query: 781 FDQNVLNFD 789
FDQNVLNFD
Sbjct: 781 FDQNVLNFD 789
>gi|119943086 Tax1 (human T-cell leukemia virus type I) binding
protein 1 isoform b [Homo sapiens]
Length = 747
Score = 1494 bits (3868), Expect = 0.0
Identities = 747/789 (94%), Positives = 747/789 (94%), Gaps = 42/789 (5%)
Query: 1 MTSFQEVPLQTSNFAHVIFQNVAKSYLPNAHLECHYTLTPYIHPHPKDWVGIFKVGWSTA 60
MTSFQEVPLQTSNFAHVIFQNVAKSYLPNAHLECHYTLTPYIHPHPKDWVGIFKVGWSTA
Sbjct: 1 MTSFQEVPLQTSNFAHVIFQNVAKSYLPNAHLECHYTLTPYIHPHPKDWVGIFKVGWSTA 60
Query: 61 RDYYTFLWSPMPEHYVEGSTVNCVLAFQGYYLPNDDGEFYQFCYVTHKGEIRGASTPFQF 120
RDYYTFLWSPMPEHYVEGSTVNCVLAFQGYYLPNDDGEFYQFCYVTHKGEIRGASTPFQF
Sbjct: 61 RDYYTFLWSPMPEHYVEGSTVNCVLAFQGYYLPNDDGEFYQFCYVTHKGEIRGASTPFQF 120
Query: 121 RASSPVEELLTMEDEGNSDMLVVTTKAGLLELKIEKTMKEKEELLKLIAVLEKETAQLRE 180
RASSPVEELLTMEDEGNSDMLVVTTKAGLLELKIEKTMKEKEELLKLIAVLEKETAQLRE
Sbjct: 121 RASSPVEELLTMEDEGNSDMLVVTTKAGLLELKIEKTMKEKEELLKLIAVLEKETAQLRE 180
Query: 181 QVGRMERELNHEKERCDQLQAEQKGLTEVTQSLKMENEEFKKRFSDATSKAHQLEEDIVS 240
QVGRMERELNHEKERCDQLQAEQKGLTEVTQSLKMENEEFKKRFSDATSKAHQLEEDIVS
Sbjct: 181 QVGRMERELNHEKERCDQLQAEQKGLTEVTQSLKMENEEFKKRFSDATSKAHQLEEDIVS 240
Query: 241 VTHKAIEKETELDSLKDKLKKAQHEREQLECQLKTEKDEKELYKVHLKNTEIENTKLMSE 300
VTHKAIEKETELDSLKDKLKKAQHEREQLECQLKTEKDEKELYKVHLKNTEIENTKLMSE
Sbjct: 241 VTHKAIEKETELDSLKDKLKKAQHEREQLECQLKTEKDEKELYKVHLKNTEIENTKLMSE 300
Query: 301 VQTLKNLDGNKESVITHFKEEIGRLQLCLAEKENLQRTFLLTTSSKEDTCFLKEQLRKAE 360
VQTLKNLDGNKESVITHFKEEIGRLQLCLAEKENLQRTFLLTTSSKEDTCFLKEQLRKAE
Sbjct: 301 VQTLKNLDGNKESVITHFKEEIGRLQLCLAEKENLQRTFLLTTSSKEDTCFLKEQLRKAE 360
Query: 361 EQVQATRQEVVFLAKELSDAVNVRDRTMADLHTARLENEKVKKQLADAVAELKLNAMKKD 420
EQVQATRQEVVFLAKELSDAVNVRDRTMADLHTARLENEKVKKQLADAVAELKLNAMKKD
Sbjct: 361 EQVQATRQEVVFLAKELSDAVNVRDRTMADLHTARLENEKVKKQLADAVAELKLNAMKKD 420
Query: 421 QDKTDTLEHELRREVEDLKLRLQMAADHYKEKFKECQRLQKQINKLSDQSANNNNVFTKK 480
QDKTDTLEHELRREVEDLKLRLQMAADHYKEKFKECQRLQKQINKLSDQSANNNNVFTKK
Sbjct: 421 QDKTDTLEHELRREVEDLKLRLQMAADHYKEKFKECQRLQKQINKLSDQSANNNNVFTKK 480
Query: 481 TGNQQKVNDASVNTDPATSASTVDVKPSPSAAEADFDIVTKGQVCEMTKEIADKTEKYNK 540
TGNQQKVNDASVNTDPATSASTVDVKPSPSAAEADFDIVTKGQVCEMTKEIADKTEKYNK
Sbjct: 481 TGNQQKVNDASVNTDPATSASTVDVKPSPSAAEADFDIVTKGQVCEMTKEIADKTEKYNK 540
Query: 541 CKQLLQDEKAKCNKYADELAKMELKWKEQVKIAENVKLELAEVQDNYKELKRSLENPAER 600
CKQLLQDEKAKCNKYADELAKMELKWKEQVKIAENVKLELAEVQDNYKELKRSLENPAER
Sbjct: 541 CKQLLQDEKAKCNKYADELAKMELKWKEQVKIAENVKLELAEVQDNYKELKRSLENPAER 600
Query: 601 KMEGQNSQSPQCFKTCSEQNGYVLTLSNAQPVLQYGNPYASQETRDGADGAFYPDEIQRP 660
KME DGADGAFYPDEIQRP
Sbjct: 601 KME------------------------------------------DGADGAFYPDEIQRP 618
Query: 661 PVRVPSWGLEDNVVCSQPARNFSRPDGLEDSEDSKEDENVPTAPDPPSQHLRGHGTGFCF 720
PVRVPSWGLEDNVVCSQPARNFSRPDGLEDSEDSKEDENVPTAPDPPSQHLRGHGTGFCF
Sbjct: 619 PVRVPSWGLEDNVVCSQPARNFSRPDGLEDSEDSKEDENVPTAPDPPSQHLRGHGTGFCF 678
Query: 721 DSSFDVHKKCPLCELMFPPNYDQSKFEEHVESHWKVCPMCSEQFPPDYDQQVFERHVQTH 780
DSSFDVHKKCPLCELMFPPNYDQSKFEEHVESHWKVCPMCSEQFPPDYDQQVFERHVQTH
Sbjct: 679 DSSFDVHKKCPLCELMFPPNYDQSKFEEHVESHWKVCPMCSEQFPPDYDQQVFERHVQTH 738
Query: 781 FDQNVLNFD 789
FDQNVLNFD
Sbjct: 739 FDQNVLNFD 747
>gi|14149742 coiled-coil transcriptional coactivator isoform 1 [Homo
sapiens]
Length = 691
Score = 275 bits (702), Expect = 2e-73
Identities = 207/753 (27%), Positives = 352/753 (46%), Gaps = 102/753 (13%)
Query: 17 VIFQNVAKSYLPNAHLECHYTLTPYIHPHPKDWVGIFKVGWSTARDYYTFLWSPMPEHYV 76
V F NVA++Y+PN +ECHYTL P P DW+GIFKV + RDY+TF+WS +PE
Sbjct: 15 VNFLNVARTYIPNTKVECHYTLPPGTMPSASDWIGIFKVEAACVRDYHTFVWSSVPESTT 74
Query: 77 EGSTVNCVLAFQGYYLPNDDGEFYQFCYVTHKGEIRGASTPFQFRASSPVEELLTMED-E 135
+GS ++ + FQ YLP + YQF YV +G++ G S PFQFR P++EL+T+E+ +
Sbjct: 75 DGSPIHTSVQFQASYLPKPGAQLYQFRYVNRQGQVCGQSPPFQFREPRPMDELVTLEEAD 134
Query: 136 GNSDMLVVTTKAGLLELKIEKTMKEKEELLKLIAVLEKETAQLREQVGRMERELNHEKER 195
G SD+L+V KA +L+ +++++ +E+ +L++L LE + +LR +V +ER L ++
Sbjct: 135 GGSDILLVVPKATVLQNQLDESQQERNDLMQLKLQLEGQVTELRSRVQELERALATARQE 194
Query: 196 CDQLQAEQKGLTEVTQSLKMENEEFKKRFSDATSKAHQLEEDIVSVTHKAIEKETELDSL 255
+L + KG++ + E + ++ D ++ +LE+DI +++ K + KE ELD L
Sbjct: 195 HTELMEQYKGISRSHGEITEERDILSRQQGDHVARILELEDDIQTISEKVLTKEVELDRL 254
Query: 256 KDKLKKAQHEREQLECQLKTEKDEKELYKVHLKNTEIENTKLMSEVQTLKNLDGNKESVI 315
+D +K E+E+L QLK + +KE + L+ + EN L +++ K+ + +
Sbjct: 255 RDTVKALTREQEKLLGQLKEVQADKEQSEAELQVAQQENHHLNLDLKEAKSWQEEQSAQA 314
Query: 316 THFKEEIGRLQLCLAEKENLQRTFLLTTSSKEDTCFLKEQLRKAEEQVQATRQEVVFLAK 375
K+++ +++ L + + QR L LKEQLR A+E +++Q+ L +
Sbjct: 315 QRLKDKVAQMKDTLGQAQ--QRVAELEP--------LKEQLRGAQELAASSQQKATLLGE 364
Query: 376 ELSDAVNVRDRTMADLHTARLENEKVKKQLADAVAELKLNAMKKDQDKTDTLEHELRREV 435
EL+ A RDRT+A+LH +RLE +V +LA+ LK + +++ L+ +
Sbjct: 365 ELASAAAARDRTIAELHRSRLEVAEVNGRLAELGLHLKEEKCQWSKERAGLLQSVEAEKD 424
Query: 436 EDLKLRLQMAADHYKEKFKECQRLQKQINKLSDQSANNNNVFTKKTGNQQKVNDASVNTD 495
+ LKL E RL+K + + ++T NQ
Sbjct: 425 KILKLS------------AEILRLEKAVQE-------------ERTQNQ----------- 448
Query: 496 PATSASTVDVKPSPSAAEADFDIVTKGQVCEMTKEIADKTEKYNKCKQLLQDEKAKCNKY 555
V + A E D +V + E+ K K+ LQ+EK + +Y
Sbjct: 449 ---------VFKTELAREKDSSLVQLSESKRELTELRSALRVLQKEKEQLQEEKQELLEY 499
Query: 556 ADEL-AKMEL----KWKEQVKIA-ENVKLEL---AEVQDNYKELKRSLENP----AERKM 602
+L A++E KW E E + L A + D+ E + P ER
Sbjct: 500 MRKLEARLEKVADEKWNEDATTEDEEAAVGLSCPAALTDSEDESPEDMRLPPYGLCERGD 559
Query: 603 EGQNSQSPQCFKTCSEQNGYVLTLSNAQPVLQYGNPYASQETRDGADGAFYPDEIQRPPV 662
G + P+ + ++ +S P+ +P+ S D + + DE
Sbjct: 560 PGSSPAGPR-------EASPLVVISQPAPI----SPHLSGPAEDSSSDSEAEDEKSVLMA 608
Query: 663 RVPSWGLEDNVVCSQPARNF-SRPDGLEDSEDSKEDENVPTAPDPPSQHLRGHGTGFCFD 721
V S G E N++ + F G S+ P P
Sbjct: 609 AVQSGGEEANLLLPELGSAFYDMASGFTVGTLSETSTGGPATP----------------- 651
Query: 722 SSFDVHKKCPLCELMFPPNYDQSKFEEHVESHW 754
K+CP+C+ FP D+ E+H++ H+
Sbjct: 652 ----TWKECPICKERFPAESDKDALEDHMDGHF 680
Score = 69.7 bits (169), Expect = 1e-11
Identities = 123/587 (20%), Positives = 231/587 (39%), Gaps = 86/587 (14%)
Query: 237 DIVSVTHKAIEKETELDSLKDKLKKAQHEREQLECQLKTEKDEKELYKVHLKNTEIENTK 296
DI+ V KA + +LD + + + QLE Q+ + + + L E+T+
Sbjct: 138 DILLVVPKATVLQNQLDESQQERNDLMQLKLQLEGQVTELRSRVQELERALATARQEHTE 197
Query: 297 LMSEVQTLKNLDGNKESVITHFKEEIGRLQ----LCLAEKENLQRTFLLTTSSKEDTCFL 352
LM + + + G IT ++ + R Q + E E+ +T +KE
Sbjct: 198 LMEQYKGISRSHGE----ITEERDILSRQQGDHVARILELEDDIQTISEKVLTKE----- 248
Query: 353 KEQLRKAEEQVQATRQEVVFLAKELSDAVNVRDRTMADLHTARLENEKVKKQLADAVAEL 412
+L + + V+A +E L +L + ++++ A+L A+ EN + L +A
Sbjct: 249 -VELDRLRDTVKALTREQEKLLGQLKEVQADKEQSEAELQVAQQENHHLNLDLKEA---- 303
Query: 413 KLNAMKKDQDKTDTLEHELRREVEDLKLRLQMAADHYKEKFKECQRLQKQINKLSDQSAN 472
K Q++ L+ +V +K L A +++ E + L++Q+ + +A+
Sbjct: 304 -----KSWQEEQSAQAQRLKDKVAQMKDTLGQA----QQRVAELEPLKEQLRGAQELAAS 354
Query: 473 NNNVFTKKTGNQQKVNDASVNTDPATSASTVDVKPSPSAAEADFDIVTKGQVCEMTKEIA 532
+ T A T S ++V + A+ + K + C+ +KE A
Sbjct: 355 SQQKATLLGEELASAAAARDRTIAELHRSRLEVA-EVNGRLAELGLHLKEEKCQWSKERA 413
Query: 533 ----------DKTEKYN----KCKQLLQDEKAKCNKYADELAKMELKWKEQVKIAENVKL 578
DK K + + ++ +Q+E+ + + ELA+ K V+++E+ K
Sbjct: 414 GLLQSVEAEKDKILKLSAEILRLEKAVQEERTQNQVFKTELARE--KDSSLVQLSES-KR 470
Query: 579 ELAEVQDNYKELKRSLENPAERK---MEGQNSQSPQCFKTCSEQNGYVLTLSNAQPVLQY 635
EL E++ + L++ E E K +E + K E+ T + + +
Sbjct: 471 ELTELRSALRVLQKEKEQLQEEKQELLEYMRKLEARLEKVADEKWNEDATTEDEEAAVGL 530
Query: 636 GNPYASQETRDGADGAFYPDEIQRPPVRVPSWGLEDN-----------VVCSQPAR---N 681
P A ++ D + P++++ PP + G + VV SQPA +
Sbjct: 531 SCPAALTDSEDES-----PEDMRLPPYGLCERGDPGSSPAGPREASPLVVISQPAPISPH 585
Query: 682 FSRPDGLEDSEDSKEDEN------VPTAPDPPSQHLRGHGTGFC-FDSSFDVHKKCPLCE 734
S P S+ EDE V + + + L G+ F S F V
Sbjct: 586 LSGPAEDSSSDSEAEDEKSVLMAAVQSGGEEANLLLPELGSAFYDMASGFTVG------- 638
Query: 735 LMFPPNYDQSKFEEHVESHWKVCPMCSEQFPPDYDQQVFERHVQTHF 781
++ WK CP+C E+FP + D+ E H+ HF
Sbjct: 639 -----TLSETSTGGPATPTWKECPICKERFPAESDKDALEDHMDGHF 680
>gi|219521893 coiled-coil transcriptional coactivator isoform 2
[Homo sapiens]
Length = 606
Score = 184 bits (467), Expect = 3e-46
Identities = 179/748 (23%), Positives = 305/748 (40%), Gaps = 177/748 (23%)
Query: 17 VIFQNVAKSYLPNAHLECHYTLTPYIHPHPKDWVGIFKVGWSTARDYYTFLWSPMPEHYV 76
V F NVA++Y+PN +ECHYTL P P DW+GIFKV + RDY+TF+WS +PE
Sbjct: 15 VNFLNVARTYIPNTKVECHYTLPPGTMPSASDWIGIFKVEAACVRDYHTFVWSSVPESTT 74
Query: 77 EGSTVNCVLAFQGYYLPNDDGEFYQFCYVTHKGEIRGASTPFQFRASSPVEELLTMED-E 135
+GS ++ T QF+ P++EL+T+E+ +
Sbjct: 75 DGSPIH---------------------------------TSVQFQEPRPMDELVTLEEAD 101
Query: 136 GNSDMLVVTTKAGLLELKIEKTMKEKEELLKLIAVLEKETAQLREQVGRMERELNHEKER 195
G SD+L+V KA +L+ +++++ +E+ +L++L LE + +LR +V +ER L ++
Sbjct: 102 GGSDILLVVPKATVLQNQLDESQQERNDLMQLKLQLEGQVTELRSRVQELERALATARQE 161
Query: 196 CDQLQAEQKGLTEVTQSLKMENEEFKKRFSDATSKAHQLEEDIVSVTHKAIEKETELDSL 255
+L + KG++ + E + ++ D ++ +LE+DI +++ K + KE ELD L
Sbjct: 162 HTELMEQYKGISRSHGEITEERDILSRQQGDHVARILELEDDIQTISEKVLTKEVELDRL 221
Query: 256 KDKLKKAQHEREQLECQLKTEKDEKELYKVHLKNTEIENTKLMSEVQTLKNLDGNKESVI 315
+D +K E+E+L QLK + +KE + L+
Sbjct: 222 RDTVKALTREQEKLLGQLKEVQADKEQSEAELEPL------------------------- 256
Query: 316 THFKEEIGRLQLCLAEKENLQRTFLLTTSSKEDTCFLKEQLRKAEEQVQATRQEVVFLAK 375
KE L+ L SS++ L E
Sbjct: 257 ----------------KEQLRGAQELAASSQQKATLLGE--------------------- 279
Query: 376 ELSDAVNVRDRTMADLHTARLENEKVKKQLADAVAELKLNAMKKDQDKTDTLEHELRREV 435
EL+ A RDRT+A+LH +RLE +V +LA+ LK + +++ L+ +
Sbjct: 280 ELASAAAARDRTIAELHRSRLEVAEVNGRLAELGLHLKEEKCQWSKERAGLLQSVEAEKD 339
Query: 436 EDLKLRLQMAADHYKEKFKECQRLQKQINKLSDQSANNNNVFTKKTGNQQKVNDASVNTD 495
+ LKL E RL+K + + N VF + ++ D+S+
Sbjct: 340 KILKLS------------AEILRLEKAV----QEERTQNQVFKTELAREK---DSSL--- 377
Query: 496 PATSASTVDVKPSPSAAEADFDIVTKGQVCEMTKEIADKTEKYNKCKQLLQDEKAKCNKY 555
V+ S S E + + + KE E+ + + ++ +A+ K
Sbjct: 378 ---------VQLSESKREL---TELRSALRVLQKEKEQLQEEKQELLEYMRKLEARLEKV 425
Query: 556 ADELAKMELKWKEQVKIA-ENVKLEL---AEVQDNYKELKRSLENP----AERKMEGQNS 607
ADE KW E E + L A + D+ E + P ER G +
Sbjct: 426 ADE------KWNEDATTEDEEAAVGLSCPAALTDSEDESPEDMRLPPYGLCERGDPGSSP 479
Query: 608 QSPQCFKTCSEQNGYVLTLSNAQPVLQYGNPYASQETRDGADGAFYPDEIQRPPVRVPSW 667
P+ + ++ +S P+ +P+ S D + + DE V S
Sbjct: 480 AGPR-------EASPLVVISQPAPI----SPHLSGPAEDSSSDSEAEDEKSVLMAAVQSG 528
Query: 668 GLEDNVVCSQPARNF-SRPDGLEDSEDSKEDENVPTAPDPPSQHLRGHGTGFCFDSSFDV 726
G E N++ + F G S+ P P
Sbjct: 529 GEEANLLLPELGSAFYDMASGFTVGTLSETSTGGPATP---------------------T 567
Query: 727 HKKCPLCELMFPPNYDQSKFEEHVESHW 754
K+CP+C+ FP D+ E+H++ H+
Sbjct: 568 WKECPICKERFPAESDKDALEDHMDGHF 595
Score = 62.4 bits (150), Expect = 2e-09
Identities = 118/571 (20%), Positives = 202/571 (35%), Gaps = 106/571 (18%)
Query: 237 DIVSVTHKAIEKETELDSLKDKLKKAQHEREQLECQLKTEKDEKELYKVHLKNTEIENTK 296
DI+ V KA + +LD + + + QLE Q+ + + + L E+T+
Sbjct: 105 DILLVVPKATVLQNQLDESQQERNDLMQLKLQLEGQVTELRSRVQELERALATARQEHTE 164
Query: 297 LMSEVQTLKNLDGNKESVITHFKEEIGRLQLCLAEKENLQRTFLLTTSSKEDTCFLKEQL 356
LM + + + G IT ++ + R Q +++ R L ++D + E++
Sbjct: 165 LMEQYKGISRSHGE----ITEERDILSRQQ-----GDHVARILEL----EDDIQTISEKV 211
Query: 357 RKAEEQVQATRQEVVFLAKELSDAVNVRDRTMADLHTARLENEKVKKQLADAVAELKLNA 416
E ++ R V L +E + AD + E E +K+QL A EL ++
Sbjct: 212 LTKEVELDRLRDTVKALTREQEKLLGQLKEVQADKEQSEAELEPLKEQLRGA-QELAASS 270
Query: 417 MKKD-------------QDKTDTLEHELRREVEDLKLRLQMAADHYKEKFKECQRLQKQI 463
+K +D+T H R EV ++ RL H KE+ +CQ +++
Sbjct: 271 QQKATLLGEELASAAAARDRTIAELHRSRLEVAEVNGRLAELGLHLKEE--KCQWSKERA 328
Query: 464 NKLSDQSANNNNVFTKKTGNQQKVNDASVNTDPATSASTVD--VKPSPSAAEADFDIVTK 521
L A + + K++ + + A V + A E D +V
Sbjct: 329 GLLQSVEAEKDKIL--------KLSAEILRLEKAVQEERTQNQVFKTELAREKDSSLVQL 380
Query: 522 GQVCEMTKEIADKTEKYNKCKQLLQDEKAKCNKYADEL-AKMEL----KWKEQVKIAEN- 575
+ E+ K K+ LQ+EK + +Y +L A++E KW E +
Sbjct: 381 SESKRELTELRSALRVLQKEKEQLQEEKQELLEYMRKLEARLEKVADEKWNEDATTEDEE 440
Query: 576 --VKLEL-AEVQDNYKELKRSLENPAERKME-GQNSQSPQCFKTCSEQNGYVLTLSNAQP 631
V L A + D+ E + P E G SP + S ++ +S P
Sbjct: 441 AAVGLSCPAALTDSEDESPEDMRLPPYGLCERGDPGSSPAGPREASP----LVVISQPAP 496
Query: 632 VLQYGNPYASQETRDGADGAFYPDEIQRPPVRVPSWGLEDNVVCSQPARNF-SRPDGLED 690
+ +P+ S D + + DE V S G E N++ + F G
Sbjct: 497 I----SPHLSGPAEDSSSDSEAEDEKSVLMAAVQSGGEEANLLLPELGSAFYDMASGFTV 552
Query: 691 SEDSKEDENVPTAPDPPSQHLRGHGTGFCFDSSFDVHKKCPLCELMFPPNYDQSKFEEHV 750
S+ P P
Sbjct: 553 GTLSETSTGGPATPT--------------------------------------------- 567
Query: 751 ESHWKVCPMCSEQFPPDYDQQVFERHVQTHF 781
WK CP+C E+FP + D+ E H+ HF
Sbjct: 568 ---WKECPICKERFPAESDKDALEDHMDGHF 595
>gi|5031937 calcium binding and coiled-coil domain 2 [Homo sapiens]
Length = 446
Score = 160 bits (405), Expect = 4e-39
Identities = 107/320 (33%), Positives = 164/320 (51%), Gaps = 35/320 (10%)
Query: 7 VPLQTSNFAHVIFQNVAKSYLPNAHLECHYTLTPYIHPHPKDWVGIFKVGWSTARDYYTF 66
V L +F+ VIF +V K Y+P + CHYT T + P KDW+GIF+VGW T R+YYTF
Sbjct: 13 VLLDHCHFSQVIFNSVEKFYIPGGDVTCHYTFTQHFIPRRKDWIGIFRVGWKTTREYYTF 72
Query: 67 LWSPMPEHYVEGSTVNCVLAFQGYYLPNDDGEFYQFCYVTHKGEIRGASTPFQFRASSPV 126
+W +P S + F+ YYLP DD E+YQFCYV G +RGAS PFQFR
Sbjct: 73 MWVTLPIDLNNKSAKQQEVQFKAYYLPKDD-EYYQFCYVDEDGVVRGASIPFQFR----- 126
Query: 127 EELLTMEDEGNSDMLVVTTKAGLLELKIEKTMKEKEELLKLIAVLEKETAQLREQVGRME 186
E D+LVVTT+ ++E+ + +EL K L+ L++Q M+
Sbjct: 127 -------PENEEDILVVTTQG-----EVEEIEQHNKELCKENQELKDSCISLQKQNSDMQ 174
Query: 187 RELNHEKERCDQLQAEQKGL------------TEVTQSLKMENEEFKKRFSDATSKAHQL 234
EL ++E + LQ+ K L TE+ Q LK +N++ + QL
Sbjct: 175 AELQKKQEELETLQSINKKLELKVKEQKDYWETELLQ-LKEQNQKMSSENEKMGIRVDQL 233
Query: 235 EEDIVSVTHKAIEKETELDSLK-DKLKKAQHEREQLECQL-KTEKDEKELYKVHLKNTEI 292
+ + S K +EK + D K ++L++ + E + L L + KD+K+L + + +
Sbjct: 234 QAQL-STQEKEMEKLVQGDQDKTEQLEQLKKENDHLFLSLTEQRKDQKKLEQTVEQMKQN 292
Query: 293 ENTKLMSEVQTL-KNLDGNK 311
E T + + + + +N D +K
Sbjct: 293 ETTAMKKQQELMDENFDLSK 312
Score = 32.3 bits (72), Expect = 1.8
Identities = 67/352 (19%), Positives = 137/352 (38%), Gaps = 50/352 (14%)
Query: 419 KDQDKTDTLEHELRREVEDLKLRLQMAADHYKEKFKECQRLQKQINKLSDQSANNNNVFT 478
+ +++ D L + EVE+++ H KE KE Q L+ L Q+++
Sbjct: 126 RPENEEDILVVTTQGEVEEIE-------QHNKELCKENQELKDSCISLQKQNSDMQAELQ 178
Query: 479 KKTGNQQKVNDASVNTDPATSASTVDVKPSPSAAEADFDIVTKGQVCEMTKEIADKTEKY 538
KK + + + + + VK E + Q+ E ++++ + EK
Sbjct: 179 KKQEELETLQSINKKLE-------LKVKEQKDYWETELL-----QLKEQNQKMSSENEKM 226
Query: 539 NKCKQLLQDEKAKCNKYADELAKMELKWKEQV----KIAENVKLELAEVQDNYKELKRSL 594
LQ + + K ++L + + EQ+ K +++ L L E + + K+L++++
Sbjct: 227 GIRVDQLQAQLSTQEKEMEKLVQGDQDKTEQLEQLKKENDHLFLSLTEQRKDQKKLEQTV 286
Query: 595 EN------PAERKMEGQNSQSPQCFKTCSEQNGYVLTLSNAQPVLQYGNPYASQETRDGA 648
E A +K + ++ K SE L + L+ N +E
Sbjct: 287 EQMKQNETTAMKKQQELMDENFDLSKRLSENEIICNALQRQKERLEGENDLLKRENSRLL 346
Query: 649 DGAFYPDEIQRPPVRVPSWGLEDNVVCSQPARNFSRP-DGLEDSEDSKEDENVPTAPDPP 707
++ + P +VP+ ++ P + P G+++S S ++ P
Sbjct: 347 --SYMGLDFNSLPYQVPT--SDEGGARQNPGLAYGNPYSGIQESS-SPSPLSIKKCPICK 401
Query: 708 SQHLRGHGTG------FCFDSSFDVHKKCPLCELMFPPNYDQSKFEEHVESH 753
+ + H CF+ CP+C+ +FP ++ FE+HV H
Sbjct: 402 ADDICDHTLEQQQMQPLCFN--------CPICDKIFPAT-EKQIFEDHVFCH 444
>gi|55770834 centromere protein F [Homo sapiens]
Length = 3114
Score = 94.0 bits (232), Expect = 5e-19
Identities = 117/513 (22%), Positives = 229/513 (44%), Gaps = 55/513 (10%)
Query: 138 SDMLVVTTKAGLLELKIEKTMKEKEELLKLIAVLEKETAQLREQVGRMERELNHEKERCD 197
++M + +K L E+++ ++ EL K++ L+KE + L E++ + +R +
Sbjct: 1802 NEMKELDSKLHLQEVQLMTKIEACIELEKIVGELKKENSDLSEKLEYFSCDHQELLQRVE 1861
Query: 198 ---------QLQAEQKGLTEVTQSLKMENEEFKKRFSDATSKAHQLEEDIVSVTHKAIEK 248
++ A++ ++ ++ N+ +K+RF D ++ ++ + S+ H+A+
Sbjct: 1862 TSEGLNSDLEMHADKSSREDIGDNVAKVNDSWKERFLDVENELSRIRSEKASIEHEALYL 1921
Query: 249 ETELDSLKDK---LKKAQHEREQ----LECQLKTEKDEKELYKVHLKNTEIENTKLMSEV 301
E +L+ ++ + L+K +++ LE +L E+ + L + T L
Sbjct: 1922 EADLEVVQTEKLCLEKDNENKQKVIVCLEEELSVVTSERNQLRGELDTMSKKTTALDQLS 1981
Query: 302 QTLKNLDGNKESVITHFKEEIGRLQLCLAEKENLQRTFLLTTSSKE------DTCFLKEQ 355
+ +K ES H E + +Q +AE E ++T LL T S + D L+E+
Sbjct: 1982 EKMKEKTQELES---HQSECLHCIQ--VAEAEVKEKTELLQTLSSDVSELLKDKTHLQEK 2036
Query: 356 LRKAEEQVQA-------TRQEVVFLAKELSDAVNVRDRTMADLHTARLENEKVKKQLADA 408
L+ E+ QA ++ L KE V + A L + E V K L A
Sbjct: 2037 LQSLEKDSQALSLTKCELENQIAQLNKEKELLVKESESLQARLSESDYEKLNVSKALEAA 2096
Query: 409 VAELKLNAMKKDQDKTDTLEHELRREVEDLKLRLQMAAD-----HYKEKFKECQRLQKQI 463
+ E A++ + + H+LRR +E KLR+++ AD H EK KE +R +
Sbjct: 2097 LVEKGEFALRLSSTQEEV--HQLRRGIE--KLRVRIEADEKKQLHIAEKLKERER---EN 2149
Query: 464 NKLSDQSANNNNVFTKKTGNQQKV-NDASVNTDPATSASTVDVKPSPSAAEADFDIVT-K 521
+ L D+ N NQ+ V DA + + T + + S + D+VT +
Sbjct: 2150 DSLKDKVENLERELQMSEENQELVILDAENSKAEVETLKTQIEEMARSLKVFELDLVTLR 2209
Query: 522 GQVCEMTKEIADKTEKYNKCKQLLQDEKAKCNKYADELAKMELKWKEQVKIAENVKLELA 581
+ +TK+I +K + ++ +LL K+ + +++ + K V++ +N EL
Sbjct: 2210 SEKENLTKQIQEKQGQLSELDKLLSSFKSLLEEKEQAEIQIKEESKTAVEMLQNQLKELN 2269
Query: 582 EV-------QDNYKELKRSLENPAERKMEGQNS 607
E Q+ K ++SL+ P E + + +NS
Sbjct: 2270 EAVAALCGDQEIMKATEQSLDPPIEEEHQLRNS 2302
Score = 81.6 bits (200), Expect = 3e-15
Identities = 112/497 (22%), Positives = 205/497 (41%), Gaps = 88/497 (17%)
Query: 151 ELKIEKTMKEKEELLKLIAVLEKETAQLREQVGRMERELNHEKERCDQLQAEQKGLTEVT 210
++K + + EE+ K +L+ + Q +V +E EL + K+ +Q Q
Sbjct: 471 QIKENELRRSMEEMKKENNLLKSHSEQKAREVCHLEAELKNIKQCLNQSQ-------NFA 523
Query: 211 QSLKMENEEFKKRFSDATSKAHQLEEDIVSVTHK--AIEKETELDSLKDKLKKAQHEREQ 268
+ +K +N + D K +Q E + K + E + D +D LKK +H EQ
Sbjct: 524 EEMKAKNTSQETMLRDLQEKINQQENSLTLEKLKLAVADLEKQRDCSQDLLKKREHHIEQ 583
Query: 269 LECQL-KTEKDEKELYK-VHLKNTEIENTKLMSEVQTLKNL-DGNKESVITHFKEEIGRL 325
L +L KTEK+ K L + LK E E K E +TL + E ++T +
Sbjct: 584 LNDKLSKTEKESKALLSALELKKKEYEELK---EEKTLFSCWKSENEKLLTQME------ 634
Query: 326 QLCLAEKENLQRTFLLTTSSKEDTCFLKEQLRKAE--EQVQATRQEVVFLAKELSDAVNV 383
+EKENLQ + + +TC +Q++ E E+V+ + L+ E+ + NV
Sbjct: 635 ----SEKENLQ-----SKINHLETCLKTQQIKSHEYNERVRTLEMDRENLSVEIRNLHNV 685
Query: 384 RDRTMADLHTARLENEKVKKQLADAVAELKLNAMKKDQDKTDTLEHELRREVEDLKLRLQ 443
D ++ T +L +++++ AE +K+ + +L +VEDL+ +LQ
Sbjct: 686 LDSKSVEVETQKLAYMELQQK-----AEFSDQKHQKEIENMCLKTSQLTGQVEDLEHKLQ 740
Query: 444 MAADHYKEKFKECQRLQKQINKLSDQSANNNNVFTKKTGNQQKV---------------- 487
+ ++ +K + Q L + L D + + +Q+ +
Sbjct: 741 LLSNEIMDKDRCYQDLHAEYESLRDLLKSKDASLVTNEDHQRSLLAFDQQPAMHHSFANI 800
Query: 488 --NDASVNTDPATSASTVDVKPSPSAA------EADFDIVTKGQV-------CEMTKEIA 532
S+ ++ + D P SA +F + ++ Q+ CE +I
Sbjct: 801 IGEQGSMPSERSECRLEADQSPKNSAILQNRVDSLEFSLESQKQMNSDLQKQCEELVQIK 860
Query: 533 DKTEK----------------YNKCKQLLQDEKAKCNKYADELAKMELKWKEQVKIAENV 576
+ E+ + +L +D A N A+ L+ +E K KE + + V
Sbjct: 861 GEIEENLMKAEQMHQSFVAETSQRISKLQEDTSAHQNVVAETLSALENKEKELQLLNDKV 920
Query: 577 KLELAEVQDNYKELKRS 593
+ E AE+Q ELK+S
Sbjct: 921 ETEQAEIQ----ELKKS 933
Score = 76.6 bits (187), Expect = 8e-14
Identities = 113/560 (20%), Positives = 223/560 (39%), Gaps = 70/560 (12%)
Query: 122 ASSPVEELLTMEDEGNSDMLVVTTKAGLLELKIEKTMKEKEELLKLIAVLEKETAQLREQ 181
A + V+E + +SD+ + L+ K++ K+ + L LE + AQL ++
Sbjct: 2005 AEAEVKEKTELLQTLSSDVSELLKDKTHLQEKLQSLEKDSQALSLTKCELENQIAQLNKE 2064
Query: 182 VGRMERELNHEKERCDQLQAEQKGLTEVTQSLKMENEEFKKRFSDATSKAHQLEEDI--- 238
+ +E + R + E+ +++ ++ +E EF R S + HQL I
Sbjct: 2065 KELLVKESESLQARLSESDYEKLNVSKALEAALVEKGEFALRLSSTQEEVHQLRRGIEKL 2124
Query: 239 -----------VSVTHKAIEKETELDSLKDKLKKAQHE--------------REQLECQL 273
+ + K E+E E DSLKDK++ + E E + ++
Sbjct: 2125 RVRIEADEKKQLHIAEKLKERERENDSLKDKVENLERELQMSEENQELVILDAENSKAEV 2184
Query: 274 KTEKDEKELYKVHLKNTEIENTKLMSEVQTLKNLDGNKESVITHFKEEIGRLQLCLAEKE 333
+T K + E LK E++ L SE + L K+ ++ + + + L EKE
Sbjct: 2185 ETLKTQIEEMARSLKVFELDLVTLRSEKENLTKQIQEKQGQLSELDKLLSSFKSLLEEKE 2244
Query: 334 NLQRTFLLTTSSKEDTCFLKEQLRKAEEQVQA-TRQEVVFLAKELSDAVNVRDRTMADLH 392
Q + SK L+ QL++ E V A + + A E S D + + H
Sbjct: 2245 --QAEIQIKEESKTAVEMLQNQLKELNEAVAALCGDQEIMKATEQS-----LDPPIEEEH 2297
Query: 393 TARLENEKVKKQL-ADAVAEL-KLNAMKKDQDKTDTLE---HELRREVEDLKLRLQMAAD 447
R EK++ +L AD +L L +K+ + D L+ L RE+E + + AA
Sbjct: 2298 QLRNSIEKLRARLEADEKKQLCVLQQLKESEHHADLLKGRVENLERELEIARTNQEHAAL 2357
Query: 448 HYKEKFKECQRLQKQINKLSDQ-----------SANNNNVFTKKTGNQQKVNDASV---- 492
+ E + L+ +I ++ + N+ + Q+++++ +
Sbjct: 2358 EAENSKGEVETLKAKIEGMTQSLRGLELDVVTIRSEKENLTNELQKEQERISELEIINSS 2417
Query: 493 --NTDPATSASTVDVKPSPSAAEADFDIVTKGQVCEMTKEIADKTEKYNKCKQLLQDEKA 550
N V +K S A + + Q+ E+ + +A C KA
Sbjct: 2418 FENILQEKEQEKVQMKEKSSTAME----MLQTQLKELNERVAALHNDQEAC-------KA 2466
Query: 551 KCNKYADELAKMELKWKEQVKIAENVKLELAEVQDNYKELKRSLENPAERKMEGQNSQSP 610
K + ++ +EL+ + ++ + K +Q + L + +E+ ++K+E ++ +
Sbjct: 2467 KEQNLSSQVECLELEKAQLLQGLDEAKNNYIVLQSSVNGLIQEVED-GKQKLEKKDEEIS 2525
Query: 611 QCFKTCSEQNGYVLTLSNAQ 630
+ +Q V LS +
Sbjct: 2526 RLKNQIQDQEQLVSKLSQVE 2545
Score = 72.4 bits (176), Expect = 2e-12
Identities = 70/347 (20%), Positives = 158/347 (45%), Gaps = 43/347 (12%)
Query: 153 KIEKTMKEKEELLKLIAVLEKE--------------TAQLREQVGRMERELNHEKERCDQ 198
+++ ++++E+L+ ++ +E E T +L +++ ++ + ++ +
Sbjct: 2526 RLKNQIQDQEQLVSKLSQVEGEHQLWKEQNLELRNLTVELEQKIQVLQSKNASLQDTLEV 2585
Query: 199 LQAEQKGLTEVTQSLKMENEEFKKRFSDATSKAHQLEEDIVSVTHKAIEKETELDSLKDK 258
LQ+ K L + KM+ F ++ + T+K +L+ ++ + K E + EL K++
Sbjct: 2586 LQSSYKNLENELELTKMDKMSFVEKVNKMTAKETELQREMHEMAQKTAELQEELSGEKNR 2645
Query: 259 LKKAQHEREQLECQLKTEKDEKELYKVHLKNTEIENTKLMSEVQTLKNLDGNKESVITHF 318
L E + L ++K+ KD+ LK +EN++L + + KE +
Sbjct: 2646 L---AGELQLLLEEIKSSKDQ-------LKELTLENSELKKSLDCMHKDQVEKEGKV--- 2692
Query: 319 KEEIGRLQLCLAEKENLQRTFLLTTSSKEDTCF--LKEQLRKAEEQVQATRQEVVFL--- 373
+EEI QL L E E + LL T+ + + +E+L EE + + + E+ L
Sbjct: 2693 REEIAEYQLRLHEAEKKHQALLLDTNKQYEVEIQTYREKLTSKEECLSSQKLEIDLLKSS 2752
Query: 374 AKELSDAVNVRDRTMADLHTARLENEKVKKQL------ADAVAELKLNAMKKDQDKTDTL 427
+EL++++ + + +L +++N K QL A +L + + K+ +++ + L
Sbjct: 2753 KEELNNSLKATTQILEELKKTKMDNLKYVNQLKKENERAQGKMKLLIKSCKQLEEEKEIL 2812
Query: 428 EHEL-----RREVEDLKLRLQMAADHYKEKFKECQRLQKQINKLSDQ 469
+ EL +E + + D + KE + ++ K +D+
Sbjct: 2813 QKELSQLQAAQEKQKTGTVMDTKVDELTTEIKELKETLEEKTKEADE 2859
Score = 71.6 bits (174), Expect = 3e-12
Identities = 131/554 (23%), Positives = 235/554 (42%), Gaps = 73/554 (13%)
Query: 127 EELLTMEDEGNSDMLVVTTKAGLLELKIEKTMKEKEELLKLIAVLEKETA---QLREQVG 183
E+L +D N ++V LE ++ E+ +L + + K+T QL E++
Sbjct: 1931 EKLCLEKDNENKQKVIVC-----LEEELSVVTSERNQLRGELDTMSKKTTALDQLSEKMK 1985
Query: 184 RMERELNHEKERC----DQLQAEQKGLTEVTQSLKMENEEFKKRFSDATSKAHQLEED-- 237
+EL + C +AE K TE+ Q+L + E K + K LE+D
Sbjct: 1986 EKTQELESHQSECLHCIQVAEAEVKEKTELLQTLSSDVSELLKDKTHLQEKLQSLEKDSQ 2045
Query: 238 IVSVTHKAIE-------KETEL-----DSLKDKLKKAQHEREQLECQLKTEKDEKELYKV 285
+S+T +E KE EL +SL+ +L ++ +E+ + L+ EK + +
Sbjct: 2046 ALSLTKCELENQIAQLNKEKELLVKESESLQARLSESDYEKLNVSKALEAALVEKGEFAL 2105
Query: 286 HLKNTEIENTKLMSEVQTLK---NLDGNKESVITHFKEEIGRLQLCLAEK-ENLQRTFLL 341
L +T+ E +L ++ L+ D K+ I +E R L +K ENL+R +
Sbjct: 2106 RLSSTQEEVHQLRRGIEKLRVRIEADEKKQLHIAEKLKERERENDSLKDKVENLERELQM 2165
Query: 342 TTSSKEDTCFLKEQLRKAEEQVQATRQEVVFLAKELSDAVNVRDRTMADLHTARLENEKV 401
+ ++E L + KAE + T+ E E++ ++ V + DL T R E E +
Sbjct: 2166 SEENQE-LVILDAENSKAEVETLKTQIE------EMARSLKVFE---LDLVTLRSEKENL 2215
Query: 402 KKQLADAVAELK-----LNAMKKDQDKTDTLEHELRREVEDLKLRLQMAADHYKEKFKEC 456
KQ+ + +L L++ K ++ + E +++ E+ K ++M + KE +
Sbjct: 2216 TKQIQEKQGQLSELDKLLSSFKSLLEEKEQAEIQIK---EESKTAVEMLQNQLKELNEAV 2272
Query: 457 QRL--QKQINKLSDQSANNNNVFTKKTGNQQKVNDASVNTDPATSASTV-DVKPSPSAAE 513
L ++I K ++QS + + N + A + D + +K S A+
Sbjct: 2273 AALCGDQEIMKATEQSLDPPIEEEHQLRNSIEKLRARLEADEKKQLCVLQQLKESEHHAD 2332
Query: 514 ADFDIVTKGQV--CEMTKEIADKTEKY-----NKCKQLLQDEKAKCNKYADELAKMELKW 566
+ KG+V E EIA +++ K ++ KAK L +EL
Sbjct: 2333 -----LLKGRVENLERELEIARTNQEHAALEAENSKGEVETLKAKIEGMTQSLRGLELDV 2387
Query: 567 KEQVKIAENVKLELAEVQDNYKELK---RSLENPAERK------MEGQNSQSPQCFKT-C 616
EN+ EL + Q+ EL+ S EN + K M+ ++S + + +T
Sbjct: 2388 VTIRSEKENLTNELQKEQERISELEIINSSFENILQEKEQEKVQMKEKSSTAMEMLQTQL 2447
Query: 617 SEQNGYVLTLSNAQ 630
E N V L N Q
Sbjct: 2448 KELNERVAALHNDQ 2461
Score = 71.6 bits (174), Expect = 3e-12
Identities = 107/517 (20%), Positives = 230/517 (44%), Gaps = 92/517 (17%)
Query: 130 LTMEDEGNSDMLVVTTK-AGLLELKIEKTMKEKEELLKLIAVLEKETAQLREQVGRMERE 188
L E E S++ ++ + +L+ K ++ ++ KE+ + +L+ + +L E+V
Sbjct: 2401 LQKEQERISELEIINSSFENILQEKEQEKVQMKEKSSTAMEMLQTQLKELNERVAA---- 2456
Query: 189 LNHEKERCDQLQAEQKGLTEVTQSLKMEN-------EEFKKRFSDATSKAHQLEEDIVSV 241
L++++E C +A+++ L+ + L++E +E K + S + L +++
Sbjct: 2457 LHNDQEAC---KAKEQNLSSQVECLELEKAQLLQGLDEAKNNYIVLQSSVNGLIQEVEDG 2513
Query: 242 THKAIEKETELDSLKDKLKKAQHEREQLECQLKTEKDEKELYKVHLKNTEIEN--TKLMS 299
K +K+ E+ LK++++ ++EQL +L + E +L+K +N E+ N +L
Sbjct: 2514 KQKLEKKDEEISRLKNQIQ----DQEQLVSKLSQVEGEHQLWKE--QNLELRNLTVELEQ 2567
Query: 300 EVQTLKNLDGNKESVITHFKEEIGRLQLCLAEKENLQRTFLLTTSSKEDTCFLKEQLRKA 359
++Q L++ + + + L++ + +NL+ LT K ++
Sbjct: 2568 KIQVLQSKNASLQDT----------LEVLQSSYKNLENELELTKMDKMSFVEKVNKMTAK 2617
Query: 360 EEQVQATRQEVVFLAKELSDAVN-VRDRTMADLHTARLENEKVKKQLADAV---AELK-- 413
E ++Q E+ EL + ++ ++R +L E + K QL + +ELK
Sbjct: 2618 ETELQREMHEMAQKTAELQEELSGEKNRLAGELQLLLEEIKSSKDQLKELTLENSELKKS 2677
Query: 414 LNAMKKDQDKTDTLEHELRREVEDLKLRL------------------QMAADHYKEKF-- 453
L+ M KDQ + E ++R E+ + +LRL ++ Y+EK
Sbjct: 2678 LDCMHKDQVEK---EGKVREEIAEYQLRLHEAEKKHQALLLDTNKQYEVEIQTYREKLTS 2734
Query: 454 -KEC---QRLQKQINKLSDQSANNNNVFT-------KKT--GNQQKVNDASVNTDPATSA 500
+EC Q+L+ + K S + NN+ T KKT N + VN + A
Sbjct: 2735 KEECLSSQKLEIDLLKSSKEELNNSLKATTQILEELKKTKMDNLKYVNQLKKENERAQGK 2794
Query: 501 STVDVKPSPSAAEADFDIVTK--------------GQVCEMTKEIADKTEKYNKCKQLLQ 546
+ +K S E + +I+ K G V M ++ + T + + K+ L+
Sbjct: 2795 MKLLIK-SCKQLEEEKEILQKELSQLQAAQEKQKTGTV--MDTKVDELTTEIKELKETLE 2851
Query: 547 DEKAKCNKYADELAKMELKWKEQVKIAENVKLELAEV 583
++ + ++Y D+ + + ++ K E ++ ++A +
Sbjct: 2852 EKTKEADEYLDKYCSLLISHEKLEKAKEMLETQVAHL 2888
Score = 63.2 bits (152), Expect = 9e-10
Identities = 102/457 (22%), Positives = 184/457 (40%), Gaps = 90/457 (19%)
Query: 167 LIAVLEKETAQLREQVGRMERELN-HEKERCDQLQAEQKGLTEVTQSLKMENEEFKKRFS 225
L+ L+ + +LR ++ +E L HEKE KG Q L+++ E+ K
Sbjct: 279 LLDQLKAQNQELRNKINELELRLQGHEKE--------MKGQVNKFQELQLQLEKAKVELI 330
Query: 226 DATSKAHQLEEDIVSVTHKAIEKETELDSLKDKLKKAQHEREQLECQLKTEKDEKELYKV 285
+ ++ +++V T + + T+ +L+ KLKK E L CQ + + + +
Sbjct: 331 EKEKVLNKCRDELVRTTAQYDQASTKYTALEQKLKKL---TEDLSCQRQNAESARCSLEQ 387
Query: 286 HLKNTEIENTKLMSEVQTLKNLDGNKESVITHFKEEIGRLQLCLAEKENLQRTFLLTTSS 345
+K E E F+EE+ R QR+F +
Sbjct: 388 KIKEKEKE------------------------FQEELSR----------QQRSF----QT 409
Query: 346 KEDTCFLKEQLRKAEEQVQATRQEVVFLAKELSDAVNVRDRTMADLHTARLENEKVKKQL 405
+ C Q++A L +EL A N+ + A+L + VK+QL
Sbjct: 410 LDQECI----------QMKAR------LTQELQQAKNMHNVLQAELD----KLTSVKQQL 449
Query: 406 ADAVAELKLNAMKKDQ--DKTDTLEHELRREVEDLKLRLQMAADHYKEKFKECQRLQ--- 460
+ + E K + +Q + E+ELRR +E++K + H ++K +E L+
Sbjct: 450 ENNLEEFKQKLCRAEQAFQASQIKENELRRSMEEMKKENNLLKSHSEQKAREVCHLEAEL 509
Query: 461 KQINKLSDQSAN-NNNVFTKKTGNQQKVNDASVNTDPATSASTVDVKPSPSAAEADFDIV 519
K I + +QS N + K T + + D + ++ T++ A AD +
Sbjct: 510 KNIKQCLNQSQNFAEEMKAKNTSQETMLRDLQEKINQQENSLTLE---KLKLAVADLE-- 564
Query: 520 TKGQVCEMTKEIADKTEKYNKCKQLLQDEKAKCNKYADE-LAKMELKWKEQVKIAENVKL 578
K + C D +K + L D+ +K K + L+ +ELK KE ++ E L
Sbjct: 565 -KQRDCSQ-----DLLKKREHHIEQLNDKLSKTEKESKALLSALELKKKEYEELKEEKTL 618
Query: 579 ELAEVQDNYKELKRSLENPAERKMEGQNSQSPQCFKT 615
+N K L +E+ E ++ + + C KT
Sbjct: 619 FSCWKSENEK-LLTQMESEKE-NLQSKINHLETCLKT 653
Score = 58.9 bits (141), Expect = 2e-08
Identities = 87/520 (16%), Positives = 218/520 (41%), Gaps = 74/520 (14%)
Query: 153 KIEKTMKEKEELLKLIAVLEKETAQLREQVGRMERELNHEKERCDQLQAEQKGLTEVTQS 212
K+ KT KE + LL + + +KE +L+E+ + ++ Q+++E++ L
Sbjct: 587 KLSKTEKESKALLSALELKKKEYEELKEEKTLFSCWKSENEKLLTQMESEKENLQSKINH 646
Query: 213 LK--MENEEFKKRFSDATSKAHQLEEDIVSVTHKAIEKETELDSLKDKLKKAQHEREQLE 270
L+ ++ ++ K + + +++ + +SV + + + S++ + +K + Q +
Sbjct: 647 LETCLKTQQIKSHEYNERVRTLEMDRENLSVEIRNLHNVLDSKSVEVETQKLAYMELQQK 706
Query: 271 CQLKTEKDEKELYKVHLKNTEIEN-----------------------TKLMSEVQTLKNL 307
+ +K +KE+ + LK +++ L +E ++L++L
Sbjct: 707 AEFSDQKHQKEIENMCLKTSQLTGQVEDLEHKLQLLSNEIMDKDRCYQDLHAEYESLRDL 766
Query: 308 DGNKE-SVITHFKEEIGRLQLCLAEKENLQRTF------------------LLTTSSKED 348
+K+ S++T+ E+ R L ++ + +F L S ++
Sbjct: 767 LKSKDASLVTN--EDHQRSLLAFDQQPAMHHSFANIIGEQGSMPSERSECRLEADQSPKN 824
Query: 349 TCFLKEQLRKAEEQVQATRQEVVFLAKELSDAVNVRDRTMADLHTARLENEKVKKQLADA 408
+ L+ ++ E +++ +Q L K+ + V ++ +L A ++ + +
Sbjct: 825 SAILQNRVDSLEFSLESQKQMNSDLQKQCEELVQIKGEIEENLMKAEQMHQSFVAETSQR 884
Query: 409 VAELKLNAMKKDQDKTDTLEHELRREVEDLKLRLQMAADHYKEKFKECQRLQKQINKLSD 468
+++L ++D + E +E+ + LQ+ D + + E Q L+K N L +
Sbjct: 885 ISKL-----QEDTSAHQNVVAETLSALENKEKELQLLNDKVETEQAEIQELKKS-NHLLE 938
Query: 469 QSANNNNVFTKKTGNQQKVNDASVN-----TDPATSASTVDVKPSPSAAEADFDIVTKGQ 523
S + ++ ++K + ++ + T + + + S + +++ K +
Sbjct: 939 DSLKELQLLSETLSLEKKEMSSIISLNKREIEELTQENGTLKEINASLNQEKMNLIQKSE 998
Query: 524 -----VCEMTKEIADKTEKYNKCKQLL-----------QDEKAKCNKYADELAKMELKWK 567
+ E K I++ +++Y + K +L +D K ++ +K+E
Sbjct: 999 SFANYIDEREKSISELSDQYKQEKLILLQRCEETGNAYEDLSQKYKAAQEKNSKLECLLN 1058
Query: 568 EQVKIAENVKLELAEVQDNY-KELKRSLENPAERKMEGQN 606
E + EN K EL ++++ + KE + L A + QN
Sbjct: 1059 ECTSLCENRKNELEQLKEAFAKEHQEFLTKLAFAEERNQN 1098
Score = 53.1 bits (126), Expect = 1e-06
Identities = 83/461 (18%), Positives = 175/461 (37%), Gaps = 38/461 (8%)
Query: 156 KTMKEKEELLKLIAVLEKETAQLREQVGRMERELNHEKERCDQ-------LQAEQKGLTE 208
+ +++ +EL + L+KE Q + Q+ +E L +K++ + L+ E + L E
Sbjct: 15 RALQKIQELEGQLDKLKKEKQQRQFQLDSLEAALQKQKQKVENEKTEGTNLKRENQRLME 74
Query: 209 VTQSLKMENEEFKKRFSDATSKAHQLEEDIVSVTHKAIEK-ETELDSLKDKLKKAQHERE 267
+ +SL+ ++ S+ + +E ++ K IEK E EL K +L+++Q +
Sbjct: 75 ICESLEKTKQKISHELQVKESQVN-FQEGQLNSGKKQIEKLEQELKRCKSELERSQQAAQ 133
Query: 268 QLECQLKTEKDEKELYKVHLKNTEIENTKLMSEVQTLKNLDGNKESVITHFKEEIGRLQL 327
+ L ++++ L ++ + S+ + LK + + E+ LQ
Sbjct: 134 SADVSLNPCNTPQKIFTTPLTPSQYYSG---SKYEDLKEKYNKEVEERKRLEAEVKALQA 190
Query: 328 CLAEKENLQRTFLLTTSSKE--DTCFLKEQLRKAEEQVQATRQEVVFLAKELSDAVNVRD 385
A + Q T ++ + Q K + + Q + +
Sbjct: 191 KKASQTLPQATMNHRDIARHQASSSVFSWQQEKTPSHLSSNSQRTPIRRDFSASYFSGEQ 250
Query: 386 RTMADLHTARLENEKVKKQLADAVAELKLNAMKKDQDKTDTLEHELRREVEDLKLRLQMA 445
T ++ D + L K Q++ ELR ++ +L+LRLQ
Sbjct: 251 EVTPSRSTLQIGKRDANSSFFDNSSSPHLLDQLKAQNQ------ELRNKINELELRLQGH 304
Query: 446 ADHYKEKFKECQRLQKQINKLSDQSANNNNVFTK-------KTGNQQKVNDASVNTDPAT 498
K + + Q LQ Q+ K + V K T + + +
Sbjct: 305 EKEMKGQVNKFQELQLQLEKAKVELIEKEKVLNKCRDELVRTTAQYDQASTKYTALEQKL 364
Query: 499 SASTVDVKPSPSAAEADFDIVTKGQVCEMTKEIADKTEKYNKCKQLLQDEKAKCNKYADE 558
T D+ AE+ C + ++I +K +++ ++ L ++ E
Sbjct: 365 KKLTEDLSCQRQNAES--------ARCSLEQKIKEKEKEF---QEELSRQQRSFQTLDQE 413
Query: 559 LAKMELKWKEQVKIAENVKLELAEVQDNYKELKRSLENPAE 599
+M+ + ++++ A+N+ L D +K+ LEN E
Sbjct: 414 CIQMKARLTQELQQAKNMHNVLQAELDKLTSVKQQLENNLE 454
Score = 40.8 bits (94), Expect = 0.005
Identities = 63/279 (22%), Positives = 120/279 (43%), Gaps = 53/279 (18%)
Query: 171 LEKETAQLREQVGRMERELNHEKERCDQLQAEQKGLTEVTQSLKMENEEFKKRFSDATSK 230
L++E L+E+ +M++E+N + +QL K E +E+E + + S+
Sbjct: 1128 LKQEIMTLKEEQNKMQKEVNDLLQENEQLMKVMKTKHECQ---NLESEPIRNSVKERESE 1184
Query: 231 AHQLEEDIVSVTHKAIEKETELDSLKDKLKKAQHEREQLECQLKTEKDEKELYKVHLKNT 290
+Q + + +L+ + L + QLE L+ + ++ L+ +
Sbjct: 1185 RNQCN----------FKPQMDLEVKEISLDSYNAQLVQLEAMLRNK-------ELKLQES 1227
Query: 291 EIENTKLMSEVQTLKNLDGNKESVITHFKEEIGRLQLCL--AEKENLQRTFLLTTSSKED 348
E E L E+QT++ D ++ +EI L+ C AE++ + L+TS ++
Sbjct: 1228 EKEKECLQHELQTIRG-DLETSNLQDMQSQEISGLKDCEIDAEEKYISGPHELSTSQNDN 1286
Query: 349 T---CFLK------EQLRKAEEQVQATRQEVVFLAKELSDAVNVRDRTMADLHTARLENE 399
C L+ +L K E +QA + E+V +L+ +R E
Sbjct: 1287 AHLQCSLQTTMNKLNELEKICEILQAEKYELV-----------------TELNDSRSECI 1329
Query: 400 KVKKQLADAVAELKLNAMKKDQDKTDTLEHELRREVEDL 438
+++A+ V +L LN +K D + L EL VED+
Sbjct: 1330 TATRKMAEEVGKL-LNEVKILNDDSGLLHGEL---VEDI 1364
Score = 38.5 bits (88), Expect = 0.024
Identities = 104/546 (19%), Positives = 215/546 (39%), Gaps = 113/546 (20%)
Query: 127 EELLTMEDEGNSDMLVVTTKAGLLELKIEKTMKEKEELLKLIAVLEKETAQLREQVGRME 186
+E++T+++E N ++ ++ ++E E+L+K++ + E +
Sbjct: 1130 QEIMTLKEEQNK-----------MQKEVNDLLQENEQLMKVMKTKHECQNLESEPIRNSV 1178
Query: 187 RELNHEKERCD---QLQAEQKGLT-------EVTQSLKMENEEFKKRFSDATSKA--HQL 234
+E E+ +C+ Q+ E K ++ V + N+E K + S+ + H+L
Sbjct: 1179 KERESERNQCNFKPQMDLEVKEISLDSYNAQLVQLEAMLRNKELKLQESEKEKECLQHEL 1238
Query: 235 E----------------EDIVSVTHKAIEKETELDSLKDKLKKAQHEREQLECQLKTEKD 278
+ ++I + I+ E + S +L +Q++ L+C L+T +
Sbjct: 1239 QTIRGDLETSNLQDMQSQEISGLKDCEIDAEEKYISGPHELSTSQNDNAHLQCSLQTTMN 1298
Query: 279 E-KELYKVHLKNTEIENTKLMSEVQTLKNLDGNKESVITHFK--EEIGRLQLCLAEKENL 335
+ EL K+ + + E +L++E+ D E + K EE+G+L L
Sbjct: 1299 KLNELEKI-CEILQAEKYELVTELN-----DSRSECITATRKMAEEVGKL---------L 1343
Query: 336 QRTFLLTTSSKEDTCFLKEQLRKAEEQVQATRQEVVFLAKELSDAVNVRDRTMAD----L 391
+L S L E + E Q Q V LA L ++ + T++D +
Sbjct: 1344 NEVKILNDDSGLLHGELVEDIPGGEFGEQPNEQHPVSLA-PLDESNSYEHLTLSDKEVQM 1402
Query: 392 HTARLENEKVKKQ-----LADAVAELKLNAMKKDQDKTDTLEHE-------LRREVEDLK 439
H A L+ + + Q L D ++ + M + Q D+L+ E LR DL
Sbjct: 1403 HFAELQEKFLSLQSEHKILHDQHCQMS-SKMSELQTYVDSLKAENLVLSTNLRNFQGDLV 1461
Query: 440 LRLQMAADH--YKEKFKECQRLQKQINKLSDQSANNNNVFTKKTGNQQKVNDASVNTDPA 497
+Q+ + C ++ L D S ++TG+ ++ N + A
Sbjct: 1462 KEMQLGLEEGLVPSLSSSCVPDSSSLSSLGDSSF--YRALLEQTGDMSLLS----NLEGA 1515
Query: 498 TSASTVDV---------------KPSPSAAEADFDIVTKGQVCEMTKEIADKTE------ 536
SA+ V K +PSA + + +CE+ ++ +K E
Sbjct: 1516 VSANQCSVDEVFCSSLQEENLTRKETPSAPAKGVEELE--SLCEVYRQSLEKLEEKMESQ 1573
Query: 537 ------KYNKCKQLLQDEKAKCNKYADELAKMELKWKEQV-KIAENVKLELAEVQDNYKE 589
+ + +QLL E+ + + + +W++++ + ++ +LA + ++
Sbjct: 1574 GIMKNKEIQELEQLLSSERQELDCLRKQYLSENEQWQQKLTSVTLEMESKLAAEKKQTEQ 1633
Query: 590 LKRSLE 595
L LE
Sbjct: 1634 LSLELE 1639
>gi|22538387 A-kinase anchor protein 9 isoform 2 [Homo sapiens]
Length = 3907
Score = 90.9 bits (224), Expect = 4e-18
Identities = 119/497 (23%), Positives = 207/497 (41%), Gaps = 88/497 (17%)
Query: 172 EKETAQLREQVGRMERELNHEKERCDQL----QAEQKGLTEVTQSLKMENEEFKK----- 222
EKE L EQ+ + EL ++ E QL + ++K T Q L+ EN+ FK
Sbjct: 2202 EKEITNLEEQLEQFREELENKNEEVQQLHMQLEIQKKESTTRLQELEQENKLFKDDMEKL 2261
Query: 223 ----RFSDA--TSKAHQLEEDIVSVTHKAIEKETELDSLKDKLKKAQHEREQLECQLKTE 276
+ SDA T H L + EKE E+D L +++ K Q QLK
Sbjct: 2262 GLAIKESDAMSTQDQHVLFGKFAQIIQ---EKEVEIDQLNEQVTKLQQ-------QLKIT 2311
Query: 277 KDEKELYKVH--LKNTEIENTKLMSEVQTLKNLDGNKESVITHFKEEIGRLQLCLAEKEN 334
D K + + + +++ E + LMS+ + +K N+E I E I +LQ LA
Sbjct: 2312 TDNKVIEEKNELIRDLETQIECLMSDQECVKR---NREEEIEQLNEVIEKLQQELANIG- 2367
Query: 335 LQRTFLLTTSSKEDTCFLKEQLRKA-------EEQVQATRQEVVFLAKELSDAVNVRDRT 387
Q+T + S E+ LK QL E+QV+ +E+ F+ L + ++
Sbjct: 2368 -QKTSMNAHSLSEEADSLKHQLDVVIAEKLALEQQVETANEEMTFMKNVLKETNFKMNQL 2426
Query: 388 MADLHTARLENEKVKK--QLADAVAELKLNAMKKD---------QDKTDTLEHEL----- 431
+L + + E E V+K + + + ++ + KD +D +LE++
Sbjct: 2427 TQELFSLKRERESVEKIQSIPENSVNVAIDHLSKDKPELEVVLTEDALKSLENQTYFKSF 2486
Query: 432 ----RREVEDLKLRLQMAADHYKEKFKECQRLQKQINKLSDQSANNNNVFTKKTGNQQKV 487
+ + +L+ RL K E + KQI + +Q + KK N QK+
Sbjct: 2487 EENGKGSIINLETRLLQLESTVSAKDLELTQCYKQIKDMQEQGQFETEMLQKKIVNLQKI 2546
Query: 488 NDASVNTDPATSASTVDVKPSPSAAEADFDIVTKGQVCEMTKEIADKTEKYN--KCKQLL 545
+ V A S + ++ A+ C+ + I+ + E+ N QL
Sbjct: 2547 VEEKV---AAALVSQIQLEAVQEYAK----------FCQDNQTISSEPERTNIQNLNQLR 2593
Query: 546 QDEKA--------KCNKYADELAKMELKW---KEQVKIAENVKLELAEVQDNYKELKRSL 594
+DE + ++ ++ +M KEQV+IAE + E + EL++ L
Sbjct: 2594 EDELGSDISALTLRISELESQVVEMHTSLILEKEQVEIAEK---NVLEKEKKLLELQKLL 2650
Query: 595 ENPAERKMEGQNSQSPQ 611
E +++ E + +SPQ
Sbjct: 2651 EGNEKKQREKEKKRSPQ 2667
Score = 64.3 bits (155), Expect = 4e-10
Identities = 108/533 (20%), Positives = 226/533 (42%), Gaps = 83/533 (15%)
Query: 150 LELKIEKTMKEKEELLKLIAVLEKETAQLREQVGRME-----RELNHEKERCDQLQAEQK 204
L +++ +EK+E ++ L +++ +L+ Q +++ R H D LQA+Q+
Sbjct: 210 LTANLQQARREKDETMREFLELTEQSQKLQIQFQQLQASETLRNSTHSSTAADLLQAKQQ 269
Query: 205 GLTEVTQSLKMEN--EEFKKRFSDATS---------KAHQLEED---------------- 237
LT Q + ++ E+++K+ D T K +++E+D
Sbjct: 270 ILTHQQQLEEQDHLLEDYQKKKEDFTMQISFLQEKIKVYEMEQDKKVENSNKEEIQEKET 329
Query: 238 -IVSVTHKAIEKETELDSLKDKLKKAQHEREQLECQLKTEKDEKELYKVHLKNTEIENTK 296
I + K IE+E + LKDKL A +L+ Q+ + E + K+ L N++ + +
Sbjct: 330 IIEELNTKIIEEEKKTLELKDKLTTADKLLGELQEQIVQKNQEIKNMKLELTNSKQKERQ 389
Query: 297 LMSEVQTLKNLDGNKESVITHFKEEIGRLQLCLAEKENLQRTFLLTTSSKEDTCFLKEQL 356
E+ K L G E +L ++ Q + +++T EQL
Sbjct: 390 SSEEI---KQLMGTVE-------------ELQKRNHKDSQFETDIVQRMEQETQRKLEQL 433
Query: 357 RKAEEQVQATRQEVVFLAKELSDAVNVRDRTMADLHTARLENEKV--KKQLADAVAELKL 414
R +++ Q++V + +EL +R H A++E K K ++ +A+
Sbjct: 434 RAELDEMYG--QQIVQMKQEL-----IRQ------HMAQMEEMKTRHKGEMENALRSYSN 480
Query: 415 NAMKKDQDK-TDTLEHELRREVEDLKLRLQMAADHYKEKFKECQRLQKQINKLSDQSANN 473
+ +DQ K + +EL +++D + + + +E LQ+Q+ L ++ + +
Sbjct: 481 ITVNEDQIKLMNVAINELNIKLQDTNSQKEKLKEELGLILEEKCALQRQLEDLVEELSFS 540
Query: 474 NNVFTKK----TGNQQKVNDASVNTDPATSASTVDVKPSPSAAEADFDIVTKGQVCEMTK 529
+ + K+N+A + V S S E + + ++
Sbjct: 541 REQIQRARQTIAEQESKLNEAHKSLSTVEDLKAEIVSASESRKELELKHEAEVTNYKIKL 600
Query: 530 EIADKTEKYNKCKQLLQDEKAKCNKYADELA---KMEL-KWKEQVKIAENVKLELAEVQD 585
E+ +K EK ++ + ++A+ + +L + EL K KE ++I + +E +++D
Sbjct: 601 EMLEK-EKNAVLDRMAESQEAELERLRTQLLFSHEEELSKLKEDLEIEHRINIE--KLKD 657
Query: 586 N----YKELKRSLENPAERKMEGQNSQSPQCFKTCSEQNGYVLTLSNAQPVLQ 634
N YK+ L+N +K+E + ++QN +L +S + + Q
Sbjct: 658 NLGIHYKQQIDGLQNEMSQKIETMQFEKDNLI---TKQNQLILEISKLKDLQQ 707
Score = 61.2 bits (147), Expect = 4e-09
Identities = 100/487 (20%), Positives = 193/487 (39%), Gaps = 60/487 (12%)
Query: 149 LLELKIEKTMKEKEELLKLIAVLEKETAQLREQVGRMERELNHEKERCDQLQAEQKGLTE 208
LLE I++ + E+ ++ ++ +L+EQ+ + + K Q + E + +
Sbjct: 3121 LLEYNIQQKQSQMLEMQVELSSMKDRATELQEQLSSEKMVVAELKSELAQTKLELETTLK 3180
Query: 209 VTQSLKMENEEFKKRFSDATSKAHQLEEDIVSVTHKAIEKETELDSLKDKL-KKAQHERE 267
E E F+ D T + H L + + S K+ E + L+ K KL + + ++E
Sbjct: 3181 AQHKHLKELEAFRLEVKDKTDEVHLLNDTLASEQKKSRELQWALEKEKAKLGRSEERDKE 3240
Query: 268 QLECQLKTEKDEKELYKVHLKNTEIENTKLMSEVQTLKNLDGNKESVITHFKEEIGR-LQ 326
+LE LK + ++ + L + +L++E Q + ++ + EE GR L+
Sbjct: 3241 ELE-DLKFSLESQKQRNLQLNLLLEQQKQLLNESQ--QKIESQRMLYDAQLSEEQGRNLE 3297
Query: 327 L-CLAEKENLQRTFLLTTSSKEDTCFLKEQLRK------------AEEQVQATRQEVVFL 373
L L E E ++ + +T +E L QL+ +E+ ++ ++++
Sbjct: 3298 LQVLLESEKVRIREMSSTLDRERE--LHAQLQSSDGTGQSRPPLPSEDLLKELQKQLEEK 3355
Query: 374 AKELSDAVNVRDRTMADLHTARLENEKVKKQLADAVAELKLNAMKKDQDKTDTLEHELRR 433
+ + +N ++ D R + EK +Q+ + + A + Q K HEL+
Sbjct: 3356 HSRIVELLNETEKYKLDSLQTRQQMEK-DRQVHRKTLQTEQEANTEGQKKM----HELQS 3410
Query: 434 EVEDLKLRLQMAADHYKEKFKECQRLQKQINKLSDQSANNNNVFTKKTGNQQKVNDASVN 493
+VEDL+ +L+ + E QRLQ + + Q + Q +N
Sbjct: 3411 KVEDLQRQLEEKRQQVYKLDLEGQRLQGIMQEFQKQELEREEKRESRRILYQNLN----- 3465
Query: 494 TDPATSASTVDVKPSPSAAEADFDIVTKGQVCEMTKEIADKTEKYNK----------CKQ 543
+P T + T D T+ V + E K Y K C
Sbjct: 3466 -EPTTWSLTSD--------------RTRNWVLQQKIEGETKESNYAKLIEMNGGGTGCNH 3510
Query: 544 LLQDEKAKCNKYADELAKMELKWKEQVKIAENVKLELAEVQDNYKELKRSLENPAERKME 603
L+ + K A +L + K E+++ + VQ+N E+ L+ K+
Sbjct: 3511 ELEMIRQKLQCVASKLQVLPQKASERLQFETADDEDFIWVQENIDEIILQLQ-----KLT 3565
Query: 604 GQNSQSP 610
GQ + P
Sbjct: 3566 GQQGEEP 3572
Score = 60.1 bits (144), Expect = 8e-09
Identities = 107/514 (20%), Positives = 219/514 (42%), Gaps = 90/514 (17%)
Query: 107 HKGEIRGASTPF--------QFRASS-PVEELLTMEDEGNSDMLVVTTKAGLLELKIEKT 157
HKGE+ A + Q + + + EL + NS + + GL+ +
Sbjct: 467 HKGEMENALRSYSNITVNEDQIKLMNVAINELNIKLQDTNSQKEKLKEELGLILEEKCAL 526
Query: 158 MKEKEELLKLIAVLEKETAQLREQVGRMERELNHEKE---RCDQLQAEQKGLTEVTQSLK 214
++ E+L++ ++ ++ + R+ + E +LN + + L+AE +E + L+
Sbjct: 527 QRQLEDLVEELSFSREQIQRARQTIAEQESKLNEAHKSLSTVEDLKAEIVSASESRKELE 586
Query: 215 MENEEFKKRFSDATSKAHQLEEDIVSVTHKAIEKETELDSLKDKLKKAQH-EREQLECQL 273
+++E ++ T+ +LE +EKE +++ D++ ++Q E E+L QL
Sbjct: 587 LKHE------AEVTNYKIKLE---------MLEKEK--NAVLDRMAESQEAELERLRTQL 629
Query: 274 KTEKDEKELYKVHLKNTEIENTKLMSEVQTLKNLDGNKESVITHFKEEIGRLQLCLAEKE 333
+E E+ K E++ N++ K+++ H+K++I LQ +++K
Sbjct: 630 LFSHEE-----------ELSKLKEDLEIEHRINIEKLKDNLGIHYKQQIDGLQNEMSQKI 678
Query: 334 NLQRTFLLTTSSKEDTCFLKEQLRKAEEQ--VQATRQEVVFLAKELSDAVNVRDRTMADL 391
+ +K++ L+ K +Q V + +E+ EL + +
Sbjct: 679 ETMQFEKDNLITKQNQLILEISKLKDLQQSLVNSKSEEMTLQINELQKEIEI-------- 730
Query: 392 HTARLENEKVKKQLADAVAELKLNAMKKDQDKTDTLEHELRREVEDLKLRLQMAADHYKE 451
+ EK K L V EL+L KT+ LE +++ + DL +E
Sbjct: 731 ---LRQEEKEKGTLEQEVQELQL--------KTELLEKQMKEKENDL-----------QE 768
Query: 452 KFKECQRLQKQINKLSDQSANNNNVFTKKTGNQQKVNDASVNTDPATSASTVDVKPSPSA 511
KF + L+ + + L D+ ++ T Q+ +++ + S +V K
Sbjct: 769 KFAQ---LEAENSILKDEKKTLEDMLKIHTPVSQEERLIFLDSIKSKSKDSVWEKEIEIL 825
Query: 512 AEADFDIVTKGQVCEMTKEIADKTEKYNKCK-------QLLQDEKAKCNKYADELA---- 560
E + D+ K Q ++ +EI + ++ + Q LQ+E A K D+L
Sbjct: 826 IEENEDL--KQQCIQLNEEIEKQRNTFSFAEKNFEVNYQELQEEYACLLKVKDDLEDSKN 883
Query: 561 KMELKWKEQVKIAENVKLELAEVQDNYKELKRSL 594
K EL++K ++K A N +L L + ++K S+
Sbjct: 884 KQELEYKSKLK-ALNEELHLQRINPTTVKMKSSV 916
Score = 57.4 bits (137), Expect = 5e-08
Identities = 103/542 (19%), Positives = 230/542 (42%), Gaps = 86/542 (15%)
Query: 121 RASSPVEELLTMEDEGNSDMLVVTTKAGLLELKIEKTMKEKEELLKLIAVLEKETAQLRE 180
R + VE+LL E +S + K EL + ++ ++K+E + + E +LRE
Sbjct: 1849 RLQAAVEKLLEAISETSSQL--EHAKVTQTEL-MRESFRQKQEATESLKCQE----ELRE 1901
Query: 181 QVGRMERELNHEKERC-DQLQAEQKGLTEVTQSLKMENEEFKKRFSDATSKAHQLEEDIV 239
++ HE+ R +QL E V E F+++ + T +LE++++
Sbjct: 1902 RL--------HEESRAREQLAVELSKAEGVIDGYADEKTLFERQIQEKTDIIDRLEQELL 1953
Query: 240 SVTHKAIEKETELDSLKDKLKKAQHEREQLECQL---------KTEKDEKELYKVHLKNT 290
+++ E E E ++++ + ++E ++ + +TEK KE +V +
Sbjct: 1954 CASNRLQELEAEQQQIQEERELLSRQKEAMKAEAGPVEQQLLQETEKLMKEKLEVQCQAE 2013
Query: 291 EIENTKLMSEVQTLK-----------NLDGNKESVITHFKEEIGRLQLCLAEKENLQRTF 339
++ + L +V+ L+ L+ K + + +++ L+ L +
Sbjct: 2014 KVRD-DLQKQVKALEIDVEEQVSRFIELEQEKNTELMDLRQQNQALEKQLEKMRKFLDEQ 2072
Query: 340 LLTTSSKEDTCFLKEQLRKAEEQVQAT----------RQEVVFLAKEL-------SDAVN 382
+ + D +++++K E+Q++ +EV LA L S+ +
Sbjct: 2073 AIDREHERDV--FQQEIQKLEQQLKVVPRFQPISEHQTREVEQLANHLKEKTDKCSELLL 2130
Query: 383 VRDRTMADLHTARLENEKVKKQLADAVAELKLNA--MKKDQDKTDTLEHELRREVEDLKL 440
+++ D+ E EK++ ++ + L ++A +K +D+ E + E+ L++
Sbjct: 2131 SKEQLQRDIQERNEEIEKLEFRVRELEQALLVSADTFQKVEDRKHFGAVEAKPEL-SLEV 2189
Query: 441 RLQMAADHYKEKFKECQRLQKQINKLSDQSANNNNVFTKKTGNQQKVNDASVNTDPATSA 500
+LQ D K KE L++Q+ + ++ N N ++V + +
Sbjct: 2190 QLQAERDAIDRKEKEITNLEEQLEQFREELENKN----------EEVQQLHMQLEIQKKE 2239
Query: 501 STVDVKPSPSAAEADFDIVTK-GQVCEMTKEIA--DKTEKYNKCKQLLQDEKAKCNKYAD 557
ST ++ + D + K G + + ++ D+ + K Q++Q+++ + ++ +
Sbjct: 2240 STTRLQELEQENKLFKDDMEKLGLAIKESDAMSTQDQHVLFGKFAQIIQEKEVEIDQLNE 2299
Query: 558 ELAKMELKWKEQVKIAENVKLELAEVQDNYKELKRSLENPAERKMEGQNSQSPQCFKTCS 617
++ K++ +Q+KI + K V + EL R LE E M Q +C K
Sbjct: 2300 QVTKLQ----QQLKITTDNK-----VIEEKNELIRDLETQIECLMSDQ-----ECVKRNR 2345
Query: 618 EQ 619
E+
Sbjct: 2346 EE 2347
Score = 50.4 bits (119), Expect = 6e-06
Identities = 102/498 (20%), Positives = 184/498 (36%), Gaps = 87/498 (17%)
Query: 166 KLIAVLEKETAQLREQVGRMERELN---------HEKERCDQLQAEQKGLTEVTQSLKME 216
++I E E QL EQV +++++L + E L+ + + L + +K
Sbjct: 2285 QIIQEKEVEIDQLNEQVTKLQQQLKITTDNKVIEEKNELIRDLETQIECLMSDQECVKRN 2344
Query: 217 NEEFKKRFSDATSKAHQLEEDIVSVTHK----AIEKETELDSLKDKLKKAQHEREQLECQ 272
EE ++ ++ K L++++ ++ K A E DSLK +L E+ LE Q
Sbjct: 2345 REEEIEQLNEVIEK---LQQELANIGQKTSMNAHSLSEEADSLKHQLDVVIAEKLALEQQ 2401
Query: 273 LKTEKDEKELYKVHLKNTEIENTKLMSEVQTLKNLDGNKESV-----------ITHFKEE 321
++T +E K LK T + +L E+ +LK + E + I H ++
Sbjct: 2402 VETANEEMTFMKNVLKETNFKMNQLTQELFSLKRERESVEKIQSIPENSVNVAIDHLSKD 2461
Query: 322 IGRLQLCLAEK-----ENLQRTFLLTTSSKEDTCFLKEQLRKAEEQVQATRQEVVFLAKE 376
L++ L E EN + K L+ +L + E V A E+ K+
Sbjct: 2462 KPELEVVLTEDALKSLENQTYFKSFEENGKGSIINLETRLLQLESTVSAKDLELTQCYKQ 2521
Query: 377 LSDAVNVR--DRTMADLHTARLENEKVKKQLADAVAELKLNAMKKD-------------- 420
+ D + M L+ +K A V++++L A+++
Sbjct: 2522 IKDMQEQGQFETEMLQKKIVNLQKIVEEKVAAALVSQIQLEAVQEYAKFCQDNQTISSEP 2581
Query: 421 -----QDKTDTLEHELRREVEDLKLRLQMAADHYKEKFKECQRLQKQINKLSDQSANNNN 475
Q+ E EL ++ L LR+ E L+K+ +++++ N
Sbjct: 2582 ERTNIQNLNQLREDELGSDISALTLRISELESQVVEMHTSLI-LEKEQVEIAEK-----N 2635
Query: 476 VFTKKT----------GNQQKVNDASVNTDPATSASTVDVKPSPSAAEADFDIVTKGQVC 525
V K+ GN++K + P DV+ + E G
Sbjct: 2636 VLEKEKKLLELQKLLEGNEKKQREKEKKRSPQ------DVEVLKTTTELFHSNEESGFFN 2689
Query: 526 EM----TKEIADKTEKYNKCKQLLQDEKAKCNKYADELAKMELKWKEQVKIAENVKLELA 581
E+ + +A K E L K K K +EL E K V+ LA
Sbjct: 2690 ELEALRAESVATKAE--------LASYKEKAEKLQEELLVKETNMTSLQKDLSQVRDHLA 2741
Query: 582 EVQDNYKELKRSLENPAE 599
E ++ L++ E +
Sbjct: 2742 EAKEKLSILEKEDETEVQ 2759
Score = 48.5 bits (114), Expect = 2e-05
Identities = 78/366 (21%), Positives = 152/366 (41%), Gaps = 37/366 (10%)
Query: 141 LVVTTKAGLLELKIEKTMKEKEELLKLIAVLEK-ETAQLREQVGRMERELNHEKERCDQL 199
L T GLL ++ ++ E + L+K + L ++ + ++N K +
Sbjct: 3052 LGTTDAVGLLNCLEQRIQEQGVEYQAAMECLQKADRRSLLSEIQALHAQMNGRKITLKRE 3111
Query: 200 QAEQKGLTEVT----QSLKMENEEFKKRFSDATSKAHQLEEDIVSVTHKAIEKETELDSL 255
Q +K E+ Q + + E + S +A +L+E + S E ++EL
Sbjct: 3112 QESEKPSQELLEYNIQQKQSQMLEMQVELSSMKDRATELQEQLSSEKMVVAELKSELAQT 3171
Query: 256 KDKLK---KAQH----EREQLECQLKTEKDEKELYKVHLKNTEIENTKLMSEVQTLKNLD 308
K +L+ KAQH E E ++K + DE L L + + ++ +L ++ K
Sbjct: 3172 KLELETTLKAQHKHLKELEAFRLEVKDKTDEVHLLNDTLASEQKKSRELQWALEKEKAKL 3231
Query: 309 GNKESVITHFKEEIGRLQLCL--AEKENLQRTFLLTTSSKEDTCFLKEQLRKAEEQVQAT 366
G E KEE+ L+ L ++ NLQ LL K+ L ++++++++
Sbjct: 3232 GRSEE---RDKEELEDLKFSLESQKQRNLQLNLLLEQQ--------KQLLNESQQKIESQ 3280
Query: 367 RQEVVFLAKELSDAVNVRDRTMADLHTARLENEKVK-KQLADAV-AELKLNAMKKDQDKT 424
R L DA ++ LE+EKV+ ++++ + E +L+A + D T
Sbjct: 3281 RM--------LYDAQLSEEQGRNLELQVLLESEKVRIREMSSTLDRERELHAQLQSSDGT 3332
Query: 425 DTLEHELRRE--VEDLKLRLQMAADHYKEKFKECQRLQKQINKLSDQSANNNNVFTKKTG 482
L E +++L+ +L+ E E ++ + + Q + V K
Sbjct: 3333 GQSRPPLPSEDLLKELQKQLEEKHSRIVELLNETEKYKLDSLQTRQQMEKDRQVHRKTLQ 3392
Query: 483 NQQKVN 488
+Q+ N
Sbjct: 3393 TEQEAN 3398
Score = 43.1 bits (100), Expect = 0.001
Identities = 94/534 (17%), Positives = 196/534 (36%), Gaps = 106/534 (19%)
Query: 159 KEKEELLKLIAVLEKETAQLREQVGR-----MERELNHEKERC----DQLQAEQKGL--- 206
K LLK++ + K TA + E +GR ++R + + +A K
Sbjct: 1726 KANNRLLKILLEVVKTTAAVEETIGRHVLGILDRSSKSQSSASLIWRSEAEASVKSCVHE 1785
Query: 207 --TEVT--------------------QSLKMENEEFKKRF-------SDATSKAHQLEED 237
T VT + E E +R ++ + +L +
Sbjct: 1786 EHTRVTDESIPSYSGSDMPRNDINMWSKVTEEGTELSQRLVRSGFAGTEIDPENEELMLN 1845
Query: 238 IVSVTHKAIEK----------------ETELDSLKDKLKKAQHEREQLECQ------LKT 275
I S A+EK T+ + +++ ++ Q E L+CQ L
Sbjct: 1846 ISSRLQAAVEKLLEAISETSSQLEHAKVTQTELMRESFRQKQEATESLKCQEELRERLHE 1905
Query: 276 EKDEKELYKVHLKNTEIENTKLMSEVQTLKNLDGNKESVITHFKEEI----GRLQLCLAE 331
E +E V L E E + K +I ++E+ RLQ AE
Sbjct: 1906 ESRAREQLAVELSKAEGVIDGYADEKTLFERQIQEKTDIIDRLEQELLCASNRLQELEAE 1965
Query: 332 KENLQRTFLLTTSSKE----DTCFLKEQLRKAEEQVQATRQEV----------------- 370
++ +Q L + KE + +++QL + E++ + EV
Sbjct: 1966 QQQIQEERELLSRQKEAMKAEAGPVEQQLLQETEKLMKEKLEVQCQAEKVRDDLQKQVKA 2025
Query: 371 --VFLAKELSDAVNVRDRTMADLHTARLENEKVKKQLADAVAELKLNAMKKDQDKTDTLE 428
+ + +++S + + +L R +N+ ++KQL L A+ ++ ++ D +
Sbjct: 2026 LEIDVEEQVSRFIELEQEKNTELMDLRQQNQALEKQLEKMRKFLDEQAIDREHER-DVFQ 2084
Query: 429 HELRREVEDLKL-------------RLQMAADHYKEKFKECQRLQKQINKLSDQSANNNN 475
E+++ + LK+ ++ A+H KEK +C L +L N
Sbjct: 2085 QEIQKLEQQLKVVPRFQPISEHQTREVEQLANHLKEKTDKCSELLLSKEQLQRDIQERNE 2144
Query: 476 VFTKKTGNQQKVNDASVNTDPATSASTVDVKPSPSAAEADFDIVTKGQVCEMTKEIADKT 535
K +++ A + + A + V+ + A EA ++ + Q+ I K
Sbjct: 2145 EIEKLEFRVRELEQALLVS--ADTFQKVEDRKHFGAVEAKPELSLEVQLQAERDAIDRKE 2202
Query: 536 EKYNKCKQLLQDEKAKCNKYADELAKMELKWKEQVKIAENVKLELAEVQDNYKE 589
++ ++ L+ + + +E+ ++ ++ + Q K + EL + +K+
Sbjct: 2203 KEITNLEEQLEQFREELENKNEEVQQLHMQLEIQKKESTTRLQELEQENKLFKD 2256
Score = 41.6 bits (96), Expect = 0.003
Identities = 75/427 (17%), Positives = 172/427 (40%), Gaps = 45/427 (10%)
Query: 197 DQLQAEQKGLTEVTQSLKMENEEFKKRFSDATSKAHQLEEDIVSVTHKAIEKETELDSLK 256
D +E G + V ++ K N ++ F S + Q +D T L+ ++
Sbjct: 112 DDCSSEVNGCSFVMRTGKPTNLLREEEFGVDDSYSEQGAQD----------SPTHLEMME 161
Query: 257 DKLKKAQHEREQLECQLKTEKDEKELYKVHLKNTEIENTKLMSEVQTLKNLDGNKESVIT 316
+L QHE E+L +L ++ + Y T+ + ++Q + ++ +IT
Sbjct: 162 SELAGKQHEIEELNREL---EEMRVTY----------GTEGLQQLQEFEAAIKQRDGIIT 208
Query: 317 HFKEEIGRLQLCLAEKENLQRTFLLTTSSKEDTCFLKEQLRKAEEQVQATRQEVVFLAKE 376
LQ EK+ R FL T + +QL+ +E +T +
Sbjct: 209 QL---TANLQQARREKDETMREFLELTEQSQKLQIQFQQLQASETLRNSTHSSTAADLLQ 265
Query: 377 LSDAVNVRDRTMAD----LHTARLENEKVKKQLADAVAELKLNAMKKDQDKTDTLEHELR 432
+ + + + L + + E Q++ ++K+ M++D+ ++ + E++
Sbjct: 266 AKQQILTHQQQLEEQDHLLEDYQKKKEDFTMQISFLQEKIKVYEMEQDKKVENSNKEEIQ 325
Query: 433 RE---VEDLKLRLQMAADHYKEKFKECQRLQKQINKLSDQSANNN----NVFTKKTGNQQ 485
+ +E+L ++ E + K + +L +Q N N+ + T ++Q
Sbjct: 326 EKETIIEELNTKIIEEEKKTLELKDKLTTADKLLGELQEQIVQKNQEIKNMKLELTNSKQ 385
Query: 486 KVNDASVNTDPATSASTVDVKPSPSAAEADFDIVTKGQVCEMTKEI----ADKTEKYNKC 541
K +S K + ++ + DIV + + E +++ A+ E Y
Sbjct: 386 KERQSSEEIKQLMGTVEELQKRNHKDSQFETDIVQRMEQ-ETQRKLEQLRAELDEMYG-- 442
Query: 542 KQLLQDEKAKCNKYADELAKMELKWKEQVKIAENVKLELAEVQDNYKELKRSLENPAERK 601
+Q++Q ++ ++ ++ +M+ + K +++ A + +D K + ++ N K
Sbjct: 443 QQIVQMKQELIRQHMAQMEEMKTRHKGEMENALRSYSNITVNEDQIKLMNVAI-NELNIK 501
Query: 602 MEGQNSQ 608
++ NSQ
Sbjct: 502 LQDTNSQ 508
Score = 39.3 bits (90), Expect = 0.014
Identities = 103/544 (18%), Positives = 221/544 (40%), Gaps = 74/544 (13%)
Query: 119 QFRASSPVEELLTMEDEGNSDMLVVT---TKAGLLELKIEKTMKEKEELLKLIAVLEKET 175
Q SS + ++++ +S+ +VV ++ +L++E T+K + + LK + E
Sbjct: 3137 QVELSSMKDRATELQEQLSSEKMVVAELKSELAQTKLELETTLKAQHKHLKELEAFRLEV 3196
Query: 176 AQLREQVGRMERELNHEKERCDQLQ-AEQKGLTEVTQSLKMENEEFKK-RFSDATSKAHQ 233
++V + L E+++ +LQ A +K ++ +S + + EE + +FS + K
Sbjct: 3197 KDKTDEVHLLNDTLASEQKKSRELQWALEKEKAKLGRSEERDKEELEDLKFSLESQKQRN 3256
Query: 234 LEEDIVSVTHKAIEKETELDSLKDKLKKAQHEREQLECQLKTEKDEKELYKVHLKNTEIE 293
L+ +++ +E++ +L L + +K + +R + QL E+ +V L++ ++
Sbjct: 3257 LQLNLL------LEQQKQL--LNESQQKIESQRMLYDAQLSEEQGRNLELQVLLESEKVR 3308
Query: 294 NTKLMSEVQT-------LKNLDGNKESVITHFKEEIGR-LQLCLAEKENLQRTFLLTTSS 345
++ S + L++ DG +S E++ + LQ L EK + L T
Sbjct: 3309 IREMSSTLDRERELHAQLQSSDGTGQSRPPLPSEDLLKELQKQLEEKHSRIVELLNETEK 3368
Query: 346 -KEDTCFLKEQL-------RKAEEQVQATRQEVVFLAKELSDAVNVRDRTMA-------- 389
K D+ ++Q+ RK + Q E EL V R +
Sbjct: 3369 YKLDSLQTRQQMEKDRQVHRKTLQTEQEANTEGQKKMHELQSKVEDLQRQLEEKRQQVYK 3428
Query: 390 -DLHTARLEN----------EKVKKQLADAVAELKLN-----AMKKDQDKTDTLEHELRR 433
DL RL+ E+ +K+ + + LN ++ D+ + L+ ++
Sbjct: 3429 LDLEGQRLQGIMQEFQKQELEREEKRESRRILYQNLNEPTTWSLTSDRTRNWVLQQKIEG 3488
Query: 434 EVEDLKLR--LQM-----AADHYKEKFKECQRLQKQINKLS--DQSANNNNVFTKKTGN- 483
E ++ ++M +H E + Q+LQ +KL Q A+ F
Sbjct: 3489 ETKESNYAKLIEMNGGGTGCNHELEMIR--QKLQCVASKLQVLPQKASERLQFETADDED 3546
Query: 484 ----QQKVNDASVNTDPATSASTVD---VKPSPSAAEADFDIVTKGQVCEMTKEIADKTE 536
Q+ +++ + T + V PS S ++ Q E+T I+ TE
Sbjct: 3547 FIWVQENIDEIILQLQKLTGQQGEEPSLVSPSTSCGSLTERLLR--QNAELTGHISQLTE 3604
Query: 537 KYNKCKQLLQDEKAKCNKYADELAKMELKWKEQVKIAENVKLELAEVQDNYKELKRSLEN 596
+ N + ++ + + Y A + + + N++ +A ++ + K +L+
Sbjct: 3605 EKNDLRNMVMKLEEQIRWYRQTGAGRDNSSRFSLNGGANIEAIIASEKEVWNREKLTLQK 3664
Query: 597 PAER 600
+R
Sbjct: 3665 SLKR 3668
Score = 38.1 bits (87), Expect = 0.032
Identities = 68/360 (18%), Positives = 140/360 (38%), Gaps = 57/360 (15%)
Query: 153 KIEKTMKEKEELLKLIAVLEKETAQLREQVGRMERELNHEKERCDQLQAEQKGLTEVTQS 212
K+E T +EK EL + ++ L ++ Q ++ + E+ K+ +Q+ + L +
Sbjct: 944 KLEVTKREKLELSQRLSDLSEQLKQKHGEISFLNEEVKSLKQEKEQVSLRCRELEIIINH 1003
Query: 213 LKMENEEFKKRFSDATSKAHQLEEDIVSVTHKAIEKETELDSLKDKLKKAQHEREQLECQ 272
+ EN + ++ L + +V++T + E K+ K+ E ++ +
Sbjct: 1004 NRAENVQ------SCDTQVSSLLDGVVTMTSRGAEGSV------SKVNKSFGEESKIMVE 1051
Query: 273 LKT---------EKDEKELYKVHLKNT----------EIENTKLMSEVQTLKNLDGNKES 313
K E +++L HL + EN KL E+ LK+ E
Sbjct: 1052 DKVSFENMTVGEESKQEQLILDHLPSVTKESSLRATQPSENDKLQKELNVLKS-----EQ 1106
Query: 314 VITHFKEEIGRLQLCLAEKENLQRTFLLTTSSKEDT-CFLKEQLRKAEEQVQATRQEV-- 370
+ E R+ L L ++ + + K+ C LKE+L A+E+ Q++
Sbjct: 1107 NDLRLQMEAQRICLSLVYSTHVDQVREYMENEKDKALCSLKEELIFAQEEKIKELQKIHQ 1166
Query: 371 ----VFLAKELSDAVNVRDRTMADLHTARLEN-EKVKKQLADAVAELKLNAMKKD---QD 422
+E D + L A E + L + E A+K + +D
Sbjct: 1167 LELQTMKTQETGDEGKPLHLLIGKLQKAVSEECSYFLQTLCSVLGEYYTPALKCEVNAED 1226
Query: 423 KTDTLEH----------ELRREVEDLKLRLQMAADHYKEKFKECQRLQKQINKLSDQSAN 472
K ++ ++ + R EV+D + + + E++ + LQ +++K+ Q +
Sbjct: 1227 KENSGDYISENEDPELQDYRYEVQDFQENMHTLLNKVTEEYNKLLVLQTRLSKIWGQQTD 1286
Score = 38.1 bits (87), Expect = 0.032
Identities = 60/282 (21%), Positives = 123/282 (43%), Gaps = 39/282 (13%)
Query: 161 KEELLKLIAVLEKETAQLREQVGRMERELNHEKERCD----QLQAEQKGLTEVTQSL--- 213
++EL I+ L ++L QV M L EKE+ + + ++K L E+ + L
Sbjct: 2594 EDELGSDISALTLRISELESQVVEMHTSLILEKEQVEIAEKNVLEKEKKLLELQKLLEGN 2653
Query: 214 -KMENEEFKKR-------FSDATSKAHQLEE-----DIVSVTHKAIEKETELDSLKDKLK 260
K + E+ KKR T H EE ++ ++ +++ + EL S K+K +
Sbjct: 2654 EKKQREKEKKRSPQDVEVLKTTTELFHSNEESGFFNELEALRAESVATKAELASYKEKAE 2713
Query: 261 KAQHEREQLECQLKTEKDEKELYKVHLKNTEIENTKLMSEVQTLKNLDGNKESVITHFKE 320
K Q E E + + + + + HL + + + L E +T + +K++ + F+
Sbjct: 2714 KLQEELLVKETNMTSLQKDLSQVRDHLAEAKEKLSILEKEDET--EVQESKKACM--FEP 2769
Query: 321 EIGRLQLCLAEKENLQRTFLLTTSSKEDTCFLKEQLRKAEEQVQATRQEVVFLAKELSDA 380
+L +A + + T +++S++ +K + Q + + +EV + + ++
Sbjct: 2770 LPIKLSKSIASQTD--GTLKISSSNQTPQILVKNAGIQINLQSECSSEEVTEIISQFTEK 2827
Query: 381 VNVRDRTMADLHTARL---------ENEKVKKQLADAVAELK 413
+ M +LH A + E E +K++ AV LK
Sbjct: 2828 I----EKMQELHAAEILDMESRHISETETLKREHYVAVQLLK 2865
Score = 34.3 bits (77), Expect = 0.46
Identities = 79/392 (20%), Positives = 157/392 (40%), Gaps = 49/392 (12%)
Query: 128 ELLTMEDEGNSDMLVVTTKAGLLELKIEKTMKEKEELLKLIAVLEKETAQLRE-QVGRME 186
++ +ED + +++ L + K+E+ ++E E L+ + KET Q E ++ ++
Sbjct: 1310 QMTNLEDIDVNHKSKLSSLQDLEKTKLEEQVQELESLISSLQQQLKETEQNYEAEIHCLQ 1369
Query: 187 RELNHEKERC--DQLQAEQKGLTEVTQSLKMENEEFKKRFSDATSK-------------- 230
+ L E L + +TE M K+ D T +
Sbjct: 1370 KRLQAVSESTVPPSLPVDSVVITESDAQRTMYPGSCVKKNIDGTIEFSGEFGVKEETNIV 1429
Query: 231 -------AHQLEEDIVSVTHK---AIEKETELDSLK-DKLKKAQHEREQLECQLKTEK-D 278
QLEE++ V A ++TEL + K A ++ CQ + +
Sbjct: 1430 KLLEKQYQEQLEEEVAKVIVSMSIAFAQQTELSRISGGKENTASSKQAHAVCQQEQHYFN 1489
Query: 279 EKELY--KVHLKNTEIENTKLMSEVQTLKNLDG--NKESVITHF-KEEIGRLQLCL---- 329
E +L ++ + E + K E + L G KE ++++ +I + C+
Sbjct: 1490 EMKLSQDQIGFQTFETVDVKFKEEFKPLSKELGEHGKEILLSNSDPHDIPESKDCVLTIS 1549
Query: 330 AEKENLQRTFLLTTSSKED----TCFLKEQLRKAEEQVQATRQEVVFLAKELSDAVN-VR 384
E + +TF++ S ++ + QL EEQ++ RQE+V +E A +R
Sbjct: 1550 EEMFSKDKTFIVRQSIHDEISVSSMDASRQLMLNEEQLEDMRQELVRQYQEHQQATELLR 1609
Query: 385 DRTMADLHTARLENEKVKKQLADAVAELKLNAMKKDQDKTDTLEHELRREVEDLKLRLQM 444
M + R + E++++++ +L + +++ E L E+E LK +L +
Sbjct: 1610 QAHMRQMERQREDQEQLQEEIKRLNRQLAQRSSIDNENLVSERERVLLEELEALK-QLSL 1668
Query: 445 AADHYKEKFKECQRLQKQINKLSDQSANNNNV 476
A + K C L+ + + + N V
Sbjct: 1669 AG-----REKLCCELRNSSTQTQNGNENQGEV 1695
Score = 30.4 bits (67), Expect = 6.7
Identities = 75/354 (21%), Positives = 133/354 (37%), Gaps = 45/354 (12%)
Query: 159 KEKEELLKLIAVLEKETAQLREQVGRMERELNHEKERCDQLQAEQKGLTEVTQSLKMENE 218
+E + L + V+ E L +QV E+ K + + LT+ SLK E E
Sbjct: 2379 EEADSLKHQLDVVIAEKLALEQQVETANEEMTFMKNVLKETNFKMNQLTQELFSLKRERE 2438
Query: 219 EFKKRFS----------DATSK-AHQLEEDIVSVTHKAIEKETELDSLKDKLKKAQHERE 267
+K S D SK +LE + K++E +T S ++ K + E
Sbjct: 2439 SVEKIQSIPENSVNVAIDHLSKDKPELEVVLTEDALKSLENQTYFKSFEENGKGSIINLE 2498
Query: 268 QLECQLKTEKDEKEL--------YKVHLKNTEIENTKLMSEVQTLKNLDGNKESVITHFK 319
QL++ K+L K + + E L ++ L+ + K + +
Sbjct: 2499 TRLLQLESTVSAKDLELTQCYKQIKDMQEQGQFETEMLQKKIVNLQKIVEEKVAAALVSQ 2558
Query: 320 EEIGRLQ----LCL--------AEKENLQRTFLLTTSS-KEDTCFLKEQLRKAEEQVQAT 366
++ +Q C E+ N+Q L D L ++ + E QV
Sbjct: 2559 IQLEAVQEYAKFCQDNQTISSEPERTNIQNLNQLREDELGSDISALTLRISELESQVVEM 2618
Query: 367 RQEVVFLAKELSDA-VNVRDRTMADLHTARL-------ENEKVKKQLADAVAELKLNAMK 418
++ +++ A NV ++ L +L + EK KK+ V LK
Sbjct: 2619 HTSLILEKEQVEIAEKNVLEKEKKLLELQKLLEGNEKKQREKEKKRSPQDVEVLKTTTEL 2678
Query: 419 KDQDKTDTLEHELRR-EVEDLKLRLQMAADHYKEKFKECQR--LQKQINKLSDQ 469
++ +EL E + + ++A+ YKEK ++ Q L K+ N S Q
Sbjct: 2679 FHSNEESGFFNELEALRAESVATKAELAS--YKEKAEKLQEELLVKETNMTSLQ 2730
>gi|22538393 A-kinase anchor protein 9 isoform 3 [Homo sapiens]
Length = 3899
Score = 90.9 bits (224), Expect = 4e-18
Identities = 119/497 (23%), Positives = 207/497 (41%), Gaps = 88/497 (17%)
Query: 172 EKETAQLREQVGRMERELNHEKERCDQL----QAEQKGLTEVTQSLKMENEEFKK----- 222
EKE L EQ+ + EL ++ E QL + ++K T Q L+ EN+ FK
Sbjct: 2194 EKEITNLEEQLEQFREELENKNEEVQQLHMQLEIQKKESTTRLQELEQENKLFKDDMEKL 2253
Query: 223 ----RFSDA--TSKAHQLEEDIVSVTHKAIEKETELDSLKDKLKKAQHEREQLECQLKTE 276
+ SDA T H L + EKE E+D L +++ K Q QLK
Sbjct: 2254 GLAIKESDAMSTQDQHVLFGKFAQIIQ---EKEVEIDQLNEQVTKLQQ-------QLKIT 2303
Query: 277 KDEKELYKVH--LKNTEIENTKLMSEVQTLKNLDGNKESVITHFKEEIGRLQLCLAEKEN 334
D K + + + +++ E + LMS+ + +K N+E I E I +LQ LA
Sbjct: 2304 TDNKVIEEKNELIRDLETQIECLMSDQECVKR---NREEEIEQLNEVIEKLQQELANIG- 2359
Query: 335 LQRTFLLTTSSKEDTCFLKEQLRKA-------EEQVQATRQEVVFLAKELSDAVNVRDRT 387
Q+T + S E+ LK QL E+QV+ +E+ F+ L + ++
Sbjct: 2360 -QKTSMNAHSLSEEADSLKHQLDVVIAEKLALEQQVETANEEMTFMKNVLKETNFKMNQL 2418
Query: 388 MADLHTARLENEKVKK--QLADAVAELKLNAMKKD---------QDKTDTLEHEL----- 431
+L + + E E V+K + + + ++ + KD +D +LE++
Sbjct: 2419 TQELFSLKRERESVEKIQSIPENSVNVAIDHLSKDKPELEVVLTEDALKSLENQTYFKSF 2478
Query: 432 ----RREVEDLKLRLQMAADHYKEKFKECQRLQKQINKLSDQSANNNNVFTKKTGNQQKV 487
+ + +L+ RL K E + KQI + +Q + KK N QK+
Sbjct: 2479 EENGKGSIINLETRLLQLESTVSAKDLELTQCYKQIKDMQEQGQFETEMLQKKIVNLQKI 2538
Query: 488 NDASVNTDPATSASTVDVKPSPSAAEADFDIVTKGQVCEMTKEIADKTEKYN--KCKQLL 545
+ V A S + ++ A+ C+ + I+ + E+ N QL
Sbjct: 2539 VEEKV---AAALVSQIQLEAVQEYAK----------FCQDNQTISSEPERTNIQNLNQLR 2585
Query: 546 QDEKA--------KCNKYADELAKMELKW---KEQVKIAENVKLELAEVQDNYKELKRSL 594
+DE + ++ ++ +M KEQV+IAE + E + EL++ L
Sbjct: 2586 EDELGSDISALTLRISELESQVVEMHTSLILEKEQVEIAEK---NVLEKEKKLLELQKLL 2642
Query: 595 ENPAERKMEGQNSQSPQ 611
E +++ E + +SPQ
Sbjct: 2643 EGNEKKQREKEKKRSPQ 2659
Score = 64.3 bits (155), Expect = 4e-10
Identities = 108/533 (20%), Positives = 226/533 (42%), Gaps = 83/533 (15%)
Query: 150 LELKIEKTMKEKEELLKLIAVLEKETAQLREQVGRME-----RELNHEKERCDQLQAEQK 204
L +++ +EK+E ++ L +++ +L+ Q +++ R H D LQA+Q+
Sbjct: 210 LTANLQQARREKDETMREFLELTEQSQKLQIQFQQLQASETLRNSTHSSTAADLLQAKQQ 269
Query: 205 GLTEVTQSLKMEN--EEFKKRFSDATS---------KAHQLEED---------------- 237
LT Q + ++ E+++K+ D T K +++E+D
Sbjct: 270 ILTHQQQLEEQDHLLEDYQKKKEDFTMQISFLQEKIKVYEMEQDKKVENSNKEEIQEKET 329
Query: 238 -IVSVTHKAIEKETELDSLKDKLKKAQHEREQLECQLKTEKDEKELYKVHLKNTEIENTK 296
I + K IE+E + LKDKL A +L+ Q+ + E + K+ L N++ + +
Sbjct: 330 IIEELNTKIIEEEKKTLELKDKLTTADKLLGELQEQIVQKNQEIKNMKLELTNSKQKERQ 389
Query: 297 LMSEVQTLKNLDGNKESVITHFKEEIGRLQLCLAEKENLQRTFLLTTSSKEDTCFLKEQL 356
E+ K L G E +L ++ Q + +++T EQL
Sbjct: 390 SSEEI---KQLMGTVE-------------ELQKRNHKDSQFETDIVQRMEQETQRKLEQL 433
Query: 357 RKAEEQVQATRQEVVFLAKELSDAVNVRDRTMADLHTARLENEKV--KKQLADAVAELKL 414
R +++ Q++V + +EL +R H A++E K K ++ +A+
Sbjct: 434 RAELDEMYG--QQIVQMKQEL-----IRQ------HMAQMEEMKTRHKGEMENALRSYSN 480
Query: 415 NAMKKDQDK-TDTLEHELRREVEDLKLRLQMAADHYKEKFKECQRLQKQINKLSDQSANN 473
+ +DQ K + +EL +++D + + + +E LQ+Q+ L ++ + +
Sbjct: 481 ITVNEDQIKLMNVAINELNIKLQDTNSQKEKLKEELGLILEEKCALQRQLEDLVEELSFS 540
Query: 474 NNVFTKK----TGNQQKVNDASVNTDPATSASTVDVKPSPSAAEADFDIVTKGQVCEMTK 529
+ + K+N+A + V S S E + + ++
Sbjct: 541 REQIQRARQTIAEQESKLNEAHKSLSTVEDLKAEIVSASESRKELELKHEAEVTNYKIKL 600
Query: 530 EIADKTEKYNKCKQLLQDEKAKCNKYADELA---KMEL-KWKEQVKIAENVKLELAEVQD 585
E+ +K EK ++ + ++A+ + +L + EL K KE ++I + +E +++D
Sbjct: 601 EMLEK-EKNAVLDRMAESQEAELERLRTQLLFSHEEELSKLKEDLEIEHRINIE--KLKD 657
Query: 586 N----YKELKRSLENPAERKMEGQNSQSPQCFKTCSEQNGYVLTLSNAQPVLQ 634
N YK+ L+N +K+E + ++QN +L +S + + Q
Sbjct: 658 NLGIHYKQQIDGLQNEMSQKIETMQFEKDNLI---TKQNQLILEISKLKDLQQ 707
Score = 61.2 bits (147), Expect = 4e-09
Identities = 100/487 (20%), Positives = 193/487 (39%), Gaps = 60/487 (12%)
Query: 149 LLELKIEKTMKEKEELLKLIAVLEKETAQLREQVGRMERELNHEKERCDQLQAEQKGLTE 208
LLE I++ + E+ ++ ++ +L+EQ+ + + K Q + E + +
Sbjct: 3113 LLEYNIQQKQSQMLEMQVELSSMKDRATELQEQLSSEKMVVAELKSELAQTKLELETTLK 3172
Query: 209 VTQSLKMENEEFKKRFSDATSKAHQLEEDIVSVTHKAIEKETELDSLKDKL-KKAQHERE 267
E E F+ D T + H L + + S K+ E + L+ K KL + + ++E
Sbjct: 3173 AQHKHLKELEAFRLEVKDKTDEVHLLNDTLASEQKKSRELQWALEKEKAKLGRSEERDKE 3232
Query: 268 QLECQLKTEKDEKELYKVHLKNTEIENTKLMSEVQTLKNLDGNKESVITHFKEEIGR-LQ 326
+LE LK + ++ + L + +L++E Q + ++ + EE GR L+
Sbjct: 3233 ELE-DLKFSLESQKQRNLQLNLLLEQQKQLLNESQ--QKIESQRMLYDAQLSEEQGRNLE 3289
Query: 327 L-CLAEKENLQRTFLLTTSSKEDTCFLKEQLRK------------AEEQVQATRQEVVFL 373
L L E E ++ + +T +E L QL+ +E+ ++ ++++
Sbjct: 3290 LQVLLESEKVRIREMSSTLDRERE--LHAQLQSSDGTGQSRPPLPSEDLLKELQKQLEEK 3347
Query: 374 AKELSDAVNVRDRTMADLHTARLENEKVKKQLADAVAELKLNAMKKDQDKTDTLEHELRR 433
+ + +N ++ D R + EK +Q+ + + A + Q K HEL+
Sbjct: 3348 HSRIVELLNETEKYKLDSLQTRQQMEK-DRQVHRKTLQTEQEANTEGQKKM----HELQS 3402
Query: 434 EVEDLKLRLQMAADHYKEKFKECQRLQKQINKLSDQSANNNNVFTKKTGNQQKVNDASVN 493
+VEDL+ +L+ + E QRLQ + + Q + Q +N
Sbjct: 3403 KVEDLQRQLEEKRQQVYKLDLEGQRLQGIMQEFQKQELEREEKRESRRILYQNLN----- 3457
Query: 494 TDPATSASTVDVKPSPSAAEADFDIVTKGQVCEMTKEIADKTEKYNK----------CKQ 543
+P T + T D T+ V + E K Y K C
Sbjct: 3458 -EPTTWSLTSD--------------RTRNWVLQQKIEGETKESNYAKLIEMNGGGTGCNH 3502
Query: 544 LLQDEKAKCNKYADELAKMELKWKEQVKIAENVKLELAEVQDNYKELKRSLENPAERKME 603
L+ + K A +L + K E+++ + VQ+N E+ L+ K+
Sbjct: 3503 ELEMIRQKLQCVASKLQVLPQKASERLQFETADDEDFIWVQENIDEIILQLQ-----KLT 3557
Query: 604 GQNSQSP 610
GQ + P
Sbjct: 3558 GQQGEEP 3564
Score = 60.1 bits (144), Expect = 8e-09
Identities = 107/514 (20%), Positives = 219/514 (42%), Gaps = 90/514 (17%)
Query: 107 HKGEIRGASTPF--------QFRASS-PVEELLTMEDEGNSDMLVVTTKAGLLELKIEKT 157
HKGE+ A + Q + + + EL + NS + + GL+ +
Sbjct: 467 HKGEMENALRSYSNITVNEDQIKLMNVAINELNIKLQDTNSQKEKLKEELGLILEEKCAL 526
Query: 158 MKEKEELLKLIAVLEKETAQLREQVGRMERELNHEKE---RCDQLQAEQKGLTEVTQSLK 214
++ E+L++ ++ ++ + R+ + E +LN + + L+AE +E + L+
Sbjct: 527 QRQLEDLVEELSFSREQIQRARQTIAEQESKLNEAHKSLSTVEDLKAEIVSASESRKELE 586
Query: 215 MENEEFKKRFSDATSKAHQLEEDIVSVTHKAIEKETELDSLKDKLKKAQH-EREQLECQL 273
+++E ++ T+ +LE +EKE +++ D++ ++Q E E+L QL
Sbjct: 587 LKHE------AEVTNYKIKLE---------MLEKEK--NAVLDRMAESQEAELERLRTQL 629
Query: 274 KTEKDEKELYKVHLKNTEIENTKLMSEVQTLKNLDGNKESVITHFKEEIGRLQLCLAEKE 333
+E E+ K E++ N++ K+++ H+K++I LQ +++K
Sbjct: 630 LFSHEE-----------ELSKLKEDLEIEHRINIEKLKDNLGIHYKQQIDGLQNEMSQKI 678
Query: 334 NLQRTFLLTTSSKEDTCFLKEQLRKAEEQ--VQATRQEVVFLAKELSDAVNVRDRTMADL 391
+ +K++ L+ K +Q V + +E+ EL + +
Sbjct: 679 ETMQFEKDNLITKQNQLILEISKLKDLQQSLVNSKSEEMTLQINELQKEIEI-------- 730
Query: 392 HTARLENEKVKKQLADAVAELKLNAMKKDQDKTDTLEHELRREVEDLKLRLQMAADHYKE 451
+ EK K L V EL+L KT+ LE +++ + DL +E
Sbjct: 731 ---LRQEEKEKGTLEQEVQELQL--------KTELLEKQMKEKENDL-----------QE 768
Query: 452 KFKECQRLQKQINKLSDQSANNNNVFTKKTGNQQKVNDASVNTDPATSASTVDVKPSPSA 511
KF + L+ + + L D+ ++ T Q+ +++ + S +V K
Sbjct: 769 KFAQ---LEAENSILKDEKKTLEDMLKIHTPVSQEERLIFLDSIKSKSKDSVWEKEIEIL 825
Query: 512 AEADFDIVTKGQVCEMTKEIADKTEKYNKCK-------QLLQDEKAKCNKYADELA---- 560
E + D+ K Q ++ +EI + ++ + Q LQ+E A K D+L
Sbjct: 826 IEENEDL--KQQCIQLNEEIEKQRNTFSFAEKNFEVNYQELQEEYACLLKVKDDLEDSKN 883
Query: 561 KMELKWKEQVKIAENVKLELAEVQDNYKELKRSL 594
K EL++K ++K A N +L L + ++K S+
Sbjct: 884 KQELEYKSKLK-ALNEELHLQRINPTTVKMKSSV 916
Score = 55.1 bits (131), Expect = 3e-07
Identities = 103/491 (20%), Positives = 202/491 (41%), Gaps = 75/491 (15%)
Query: 121 RASSPVEELLTMEDEGNSDMLVVTTKAGLLELKIEKTMKEKEELLKLIAVLEKETAQLRE 180
R + VE+LL E +S + K EL + ++ ++K+E + + E +LRE
Sbjct: 1849 RLQAAVEKLLEAISETSSQL--EHAKVTQTEL-MRESFRQKQEATESLKCQE----ELRE 1901
Query: 181 QVGRMERELNHEKERC-DQLQAEQKGLTEVTQSLKMENEEFKKRFSDATSKAHQLEEDIV 239
++ HE+ R +QL E V E F+++ + T +LE++++
Sbjct: 1902 RL--------HEESRAREQLAVELSKAEGVIDGYADEKTLFERQIQEKTDIIDRLEQELL 1953
Query: 240 SVTHKAIEKETELDSLKDKLKKAQHEREQLECQLKTEKDEKELYKVHLKNTEIENTKLMS 299
+++ E E E + Q ERE L Q + K E + L E KLM
Sbjct: 1954 CASNRLQELEAEQQQI-------QEERELLSRQKEAMKAEAGPVEQQLLQ---ETEKLMK 2003
Query: 300 EVQTLKNLDGNKESVITHFKEEIGRLQLCLAEKENLQRTFLLTTSSKEDTCFLKEQLRKA 359
E + E V ++++ L++ + +E + R L + L++Q +
Sbjct: 2004 E---KLEVQCQAEKVRDDLQKQVKALEIDV--EEQVSRFIELEQEKNTELMDLRQQNQAL 2058
Query: 360 EEQVQATRQEVVFLAKELSDAVNVRDRTMADLHTARLENEKVKKQLADAVAELKLNAMKK 419
E+Q++ R+ FL ++ D + RD + E +K+++QL K
Sbjct: 2059 EKQLEKMRK---FLDEQAIDREHERD-------VFQQEIQKLEQQL-------------K 2095
Query: 420 DQDKTDTLEHELRREVEDLKLRLQMAADHYKEKFKECQRLQKQINKLSDQSANNNNVFTK 479
+ + REVE L A+H KEK +C L +L N K
Sbjct: 2096 VVPRFQPISEHQTREVEQL-------ANHLKEKTDKCSELLLSKEQLQRDIQERNEEIEK 2148
Query: 480 KTGNQQKVNDASVNTDPATSASTVDVKPSPS---AAEADFDIVTKGQVCEMTKEIADKTE 536
+++ A + D V+ KP S +A+ D + + + KEI + E
Sbjct: 2149 LEFRVRELEQALLVED-RKHFGAVEAKPELSLEVQLQAERDAIDRKE-----KEITNLEE 2202
Query: 537 KYNKCKQLLQDEKAKCNKYADEL-AKMELKWKEQVKIAENVKLELAEVQDNYKELKRSLE 595
+ + ++ L+++ N+ +L ++E++ KE + ++ E +D+ ++L +++
Sbjct: 2203 QLEQFREELENK----NEEVQQLHMQLEIQKKESTTRLQELEQENKLFKDDMEKLGLAIK 2258
Query: 596 NPAERKMEGQN 606
+ Q+
Sbjct: 2259 ESDAMSTQDQH 2269
Score = 50.4 bits (119), Expect = 6e-06
Identities = 102/498 (20%), Positives = 184/498 (36%), Gaps = 87/498 (17%)
Query: 166 KLIAVLEKETAQLREQVGRMERELN---------HEKERCDQLQAEQKGLTEVTQSLKME 216
++I E E QL EQV +++++L + E L+ + + L + +K
Sbjct: 2277 QIIQEKEVEIDQLNEQVTKLQQQLKITTDNKVIEEKNELIRDLETQIECLMSDQECVKRN 2336
Query: 217 NEEFKKRFSDATSKAHQLEEDIVSVTHK----AIEKETELDSLKDKLKKAQHEREQLECQ 272
EE ++ ++ K L++++ ++ K A E DSLK +L E+ LE Q
Sbjct: 2337 REEEIEQLNEVIEK---LQQELANIGQKTSMNAHSLSEEADSLKHQLDVVIAEKLALEQQ 2393
Query: 273 LKTEKDEKELYKVHLKNTEIENTKLMSEVQTLKNLDGNKESV-----------ITHFKEE 321
++T +E K LK T + +L E+ +LK + E + I H ++
Sbjct: 2394 VETANEEMTFMKNVLKETNFKMNQLTQELFSLKRERESVEKIQSIPENSVNVAIDHLSKD 2453
Query: 322 IGRLQLCLAEK-----ENLQRTFLLTTSSKEDTCFLKEQLRKAEEQVQATRQEVVFLAKE 376
L++ L E EN + K L+ +L + E V A E+ K+
Sbjct: 2454 KPELEVVLTEDALKSLENQTYFKSFEENGKGSIINLETRLLQLESTVSAKDLELTQCYKQ 2513
Query: 377 LSDAVNVR--DRTMADLHTARLENEKVKKQLADAVAELKLNAMKKD-------------- 420
+ D + M L+ +K A V++++L A+++
Sbjct: 2514 IKDMQEQGQFETEMLQKKIVNLQKIVEEKVAAALVSQIQLEAVQEYAKFCQDNQTISSEP 2573
Query: 421 -----QDKTDTLEHELRREVEDLKLRLQMAADHYKEKFKECQRLQKQINKLSDQSANNNN 475
Q+ E EL ++ L LR+ E L+K+ +++++ N
Sbjct: 2574 ERTNIQNLNQLREDELGSDISALTLRISELESQVVEMHTSLI-LEKEQVEIAEK-----N 2627
Query: 476 VFTKKT----------GNQQKVNDASVNTDPATSASTVDVKPSPSAAEADFDIVTKGQVC 525
V K+ GN++K + P DV+ + E G
Sbjct: 2628 VLEKEKKLLELQKLLEGNEKKQREKEKKRSPQ------DVEVLKTTTELFHSNEESGFFN 2681
Query: 526 EM----TKEIADKTEKYNKCKQLLQDEKAKCNKYADELAKMELKWKEQVKIAENVKLELA 581
E+ + +A K E L K K K +EL E K V+ LA
Sbjct: 2682 ELEALRAESVATKAE--------LASYKEKAEKLQEELLVKETNMTSLQKDLSQVRDHLA 2733
Query: 582 EVQDNYKELKRSLENPAE 599
E ++ L++ E +
Sbjct: 2734 EAKEKLSILEKEDETEVQ 2751
Score = 48.5 bits (114), Expect = 2e-05
Identities = 78/366 (21%), Positives = 152/366 (41%), Gaps = 37/366 (10%)
Query: 141 LVVTTKAGLLELKIEKTMKEKEELLKLIAVLEK-ETAQLREQVGRMERELNHEKERCDQL 199
L T GLL ++ ++ E + L+K + L ++ + ++N K +
Sbjct: 3044 LGTTDAVGLLNCLEQRIQEQGVEYQAAMECLQKADRRSLLSEIQALHAQMNGRKITLKRE 3103
Query: 200 QAEQKGLTEVT----QSLKMENEEFKKRFSDATSKAHQLEEDIVSVTHKAIEKETELDSL 255
Q +K E+ Q + + E + S +A +L+E + S E ++EL
Sbjct: 3104 QESEKPSQELLEYNIQQKQSQMLEMQVELSSMKDRATELQEQLSSEKMVVAELKSELAQT 3163
Query: 256 KDKLK---KAQH----EREQLECQLKTEKDEKELYKVHLKNTEIENTKLMSEVQTLKNLD 308
K +L+ KAQH E E ++K + DE L L + + ++ +L ++ K
Sbjct: 3164 KLELETTLKAQHKHLKELEAFRLEVKDKTDEVHLLNDTLASEQKKSRELQWALEKEKAKL 3223
Query: 309 GNKESVITHFKEEIGRLQLCL--AEKENLQRTFLLTTSSKEDTCFLKEQLRKAEEQVQAT 366
G E KEE+ L+ L ++ NLQ LL K+ L ++++++++
Sbjct: 3224 GRSEE---RDKEELEDLKFSLESQKQRNLQLNLLLEQQ--------KQLLNESQQKIESQ 3272
Query: 367 RQEVVFLAKELSDAVNVRDRTMADLHTARLENEKVK-KQLADAV-AELKLNAMKKDQDKT 424
R L DA ++ LE+EKV+ ++++ + E +L+A + D T
Sbjct: 3273 RM--------LYDAQLSEEQGRNLELQVLLESEKVRIREMSSTLDRERELHAQLQSSDGT 3324
Query: 425 DTLEHELRRE--VEDLKLRLQMAADHYKEKFKECQRLQKQINKLSDQSANNNNVFTKKTG 482
L E +++L+ +L+ E E ++ + + Q + V K
Sbjct: 3325 GQSRPPLPSEDLLKELQKQLEEKHSRIVELLNETEKYKLDSLQTRQQMEKDRQVHRKTLQ 3384
Query: 483 NQQKVN 488
+Q+ N
Sbjct: 3385 TEQEAN 3390
Score = 41.6 bits (96), Expect = 0.003
Identities = 75/427 (17%), Positives = 172/427 (40%), Gaps = 45/427 (10%)
Query: 197 DQLQAEQKGLTEVTQSLKMENEEFKKRFSDATSKAHQLEEDIVSVTHKAIEKETELDSLK 256
D +E G + V ++ K N ++ F S + Q +D T L+ ++
Sbjct: 112 DDCSSEVNGCSFVMRTGKPTNLLREEEFGVDDSYSEQGAQD----------SPTHLEMME 161
Query: 257 DKLKKAQHEREQLECQLKTEKDEKELYKVHLKNTEIENTKLMSEVQTLKNLDGNKESVIT 316
+L QHE E+L +L ++ + Y T+ + ++Q + ++ +IT
Sbjct: 162 SELAGKQHEIEELNREL---EEMRVTY----------GTEGLQQLQEFEAAIKQRDGIIT 208
Query: 317 HFKEEIGRLQLCLAEKENLQRTFLLTTSSKEDTCFLKEQLRKAEEQVQATRQEVVFLAKE 376
LQ EK+ R FL T + +QL+ +E +T +
Sbjct: 209 QL---TANLQQARREKDETMREFLELTEQSQKLQIQFQQLQASETLRNSTHSSTAADLLQ 265
Query: 377 LSDAVNVRDRTMAD----LHTARLENEKVKKQLADAVAELKLNAMKKDQDKTDTLEHELR 432
+ + + + L + + E Q++ ++K+ M++D+ ++ + E++
Sbjct: 266 AKQQILTHQQQLEEQDHLLEDYQKKKEDFTMQISFLQEKIKVYEMEQDKKVENSNKEEIQ 325
Query: 433 RE---VEDLKLRLQMAADHYKEKFKECQRLQKQINKLSDQSANNN----NVFTKKTGNQQ 485
+ +E+L ++ E + K + +L +Q N N+ + T ++Q
Sbjct: 326 EKETIIEELNTKIIEEEKKTLELKDKLTTADKLLGELQEQIVQKNQEIKNMKLELTNSKQ 385
Query: 486 KVNDASVNTDPATSASTVDVKPSPSAAEADFDIVTKGQVCEMTKEI----ADKTEKYNKC 541
K +S K + ++ + DIV + + E +++ A+ E Y
Sbjct: 386 KERQSSEEIKQLMGTVEELQKRNHKDSQFETDIVQRMEQ-ETQRKLEQLRAELDEMYG-- 442
Query: 542 KQLLQDEKAKCNKYADELAKMELKWKEQVKIAENVKLELAEVQDNYKELKRSLENPAERK 601
+Q++Q ++ ++ ++ +M+ + K +++ A + +D K + ++ N K
Sbjct: 443 QQIVQMKQELIRQHMAQMEEMKTRHKGEMENALRSYSNITVNEDQIKLMNVAI-NELNIK 501
Query: 602 MEGQNSQ 608
++ NSQ
Sbjct: 502 LQDTNSQ 508
Score = 39.3 bits (90), Expect = 0.014
Identities = 103/544 (18%), Positives = 221/544 (40%), Gaps = 74/544 (13%)
Query: 119 QFRASSPVEELLTMEDEGNSDMLVVT---TKAGLLELKIEKTMKEKEELLKLIAVLEKET 175
Q SS + ++++ +S+ +VV ++ +L++E T+K + + LK + E
Sbjct: 3129 QVELSSMKDRATELQEQLSSEKMVVAELKSELAQTKLELETTLKAQHKHLKELEAFRLEV 3188
Query: 176 AQLREQVGRMERELNHEKERCDQLQ-AEQKGLTEVTQSLKMENEEFKK-RFSDATSKAHQ 233
++V + L E+++ +LQ A +K ++ +S + + EE + +FS + K
Sbjct: 3189 KDKTDEVHLLNDTLASEQKKSRELQWALEKEKAKLGRSEERDKEELEDLKFSLESQKQRN 3248
Query: 234 LEEDIVSVTHKAIEKETELDSLKDKLKKAQHEREQLECQLKTEKDEKELYKVHLKNTEIE 293
L+ +++ +E++ +L L + +K + +R + QL E+ +V L++ ++
Sbjct: 3249 LQLNLL------LEQQKQL--LNESQQKIESQRMLYDAQLSEEQGRNLELQVLLESEKVR 3300
Query: 294 NTKLMSEVQT-------LKNLDGNKESVITHFKEEIGR-LQLCLAEKENLQRTFLLTTSS 345
++ S + L++ DG +S E++ + LQ L EK + L T
Sbjct: 3301 IREMSSTLDRERELHAQLQSSDGTGQSRPPLPSEDLLKELQKQLEEKHSRIVELLNETEK 3360
Query: 346 -KEDTCFLKEQL-------RKAEEQVQATRQEVVFLAKELSDAVNVRDRTMA-------- 389
K D+ ++Q+ RK + Q E EL V R +
Sbjct: 3361 YKLDSLQTRQQMEKDRQVHRKTLQTEQEANTEGQKKMHELQSKVEDLQRQLEEKRQQVYK 3420
Query: 390 -DLHTARLEN----------EKVKKQLADAVAELKLN-----AMKKDQDKTDTLEHELRR 433
DL RL+ E+ +K+ + + LN ++ D+ + L+ ++
Sbjct: 3421 LDLEGQRLQGIMQEFQKQELEREEKRESRRILYQNLNEPTTWSLTSDRTRNWVLQQKIEG 3480
Query: 434 EVEDLKLR--LQM-----AADHYKEKFKECQRLQKQINKLS--DQSANNNNVFTKKTGN- 483
E ++ ++M +H E + Q+LQ +KL Q A+ F
Sbjct: 3481 ETKESNYAKLIEMNGGGTGCNHELEMIR--QKLQCVASKLQVLPQKASERLQFETADDED 3538
Query: 484 ----QQKVNDASVNTDPATSASTVD---VKPSPSAAEADFDIVTKGQVCEMTKEIADKTE 536
Q+ +++ + T + V PS S ++ Q E+T I+ TE
Sbjct: 3539 FIWVQENIDEIILQLQKLTGQQGEEPSLVSPSTSCGSLTERLLR--QNAELTGHISQLTE 3596
Query: 537 KYNKCKQLLQDEKAKCNKYADELAKMELKWKEQVKIAENVKLELAEVQDNYKELKRSLEN 596
+ N + ++ + + Y A + + + N++ +A ++ + K +L+
Sbjct: 3597 EKNDLRNMVMKLEEQIRWYRQTGAGRDNSSRFSLNGGANIEAIIASEKEVWNREKLTLQK 3656
Query: 597 PAER 600
+R
Sbjct: 3657 SLKR 3660
Score = 38.1 bits (87), Expect = 0.032
Identities = 68/360 (18%), Positives = 140/360 (38%), Gaps = 57/360 (15%)
Query: 153 KIEKTMKEKEELLKLIAVLEKETAQLREQVGRMERELNHEKERCDQLQAEQKGLTEVTQS 212
K+E T +EK EL + ++ L ++ Q ++ + E+ K+ +Q+ + L +
Sbjct: 944 KLEVTKREKLELSQRLSDLSEQLKQKHGEISFLNEEVKSLKQEKEQVSLRCRELEIIINH 1003
Query: 213 LKMENEEFKKRFSDATSKAHQLEEDIVSVTHKAIEKETELDSLKDKLKKAQHEREQLECQ 272
+ EN + ++ L + +V++T + E K+ K+ E ++ +
Sbjct: 1004 NRAENVQ------SCDTQVSSLLDGVVTMTSRGAEGSV------SKVNKSFGEESKIMVE 1051
Query: 273 LKT---------EKDEKELYKVHLKNT----------EIENTKLMSEVQTLKNLDGNKES 313
K E +++L HL + EN KL E+ LK+ E
Sbjct: 1052 DKVSFENMTVGEESKQEQLILDHLPSVTKESSLRATQPSENDKLQKELNVLKS-----EQ 1106
Query: 314 VITHFKEEIGRLQLCLAEKENLQRTFLLTTSSKEDT-CFLKEQLRKAEEQVQATRQEV-- 370
+ E R+ L L ++ + + K+ C LKE+L A+E+ Q++
Sbjct: 1107 NDLRLQMEAQRICLSLVYSTHVDQVREYMENEKDKALCSLKEELIFAQEEKIKELQKIHQ 1166
Query: 371 ----VFLAKELSDAVNVRDRTMADLHTARLEN-EKVKKQLADAVAELKLNAMKKD---QD 422
+E D + L A E + L + E A+K + +D
Sbjct: 1167 LELQTMKTQETGDEGKPLHLLIGKLQKAVSEECSYFLQTLCSVLGEYYTPALKCEVNAED 1226
Query: 423 KTDTLEH----------ELRREVEDLKLRLQMAADHYKEKFKECQRLQKQINKLSDQSAN 472
K ++ ++ + R EV+D + + + E++ + LQ +++K+ Q +
Sbjct: 1227 KENSGDYISENEDPELQDYRYEVQDFQENMHTLLNKVTEEYNKLLVLQTRLSKIWGQQTD 1286
Score = 38.1 bits (87), Expect = 0.032
Identities = 60/282 (21%), Positives = 123/282 (43%), Gaps = 39/282 (13%)
Query: 161 KEELLKLIAVLEKETAQLREQVGRMERELNHEKERCD----QLQAEQKGLTEVTQSL--- 213
++EL I+ L ++L QV M L EKE+ + + ++K L E+ + L
Sbjct: 2586 EDELGSDISALTLRISELESQVVEMHTSLILEKEQVEIAEKNVLEKEKKLLELQKLLEGN 2645
Query: 214 -KMENEEFKKR-------FSDATSKAHQLEE-----DIVSVTHKAIEKETELDSLKDKLK 260
K + E+ KKR T H EE ++ ++ +++ + EL S K+K +
Sbjct: 2646 EKKQREKEKKRSPQDVEVLKTTTELFHSNEESGFFNELEALRAESVATKAELASYKEKAE 2705
Query: 261 KAQHEREQLECQLKTEKDEKELYKVHLKNTEIENTKLMSEVQTLKNLDGNKESVITHFKE 320
K Q E E + + + + + HL + + + L E +T + +K++ + F+
Sbjct: 2706 KLQEELLVKETNMTSLQKDLSQVRDHLAEAKEKLSILEKEDET--EVQESKKACM--FEP 2761
Query: 321 EIGRLQLCLAEKENLQRTFLLTTSSKEDTCFLKEQLRKAEEQVQATRQEVVFLAKELSDA 380
+L +A + + T +++S++ +K + Q + + +EV + + ++
Sbjct: 2762 LPIKLSKSIASQTD--GTLKISSSNQTPQILVKNAGIQINLQSECSSEEVTEIISQFTEK 2819
Query: 381 VNVRDRTMADLHTARL---------ENEKVKKQLADAVAELK 413
+ M +LH A + E E +K++ AV LK
Sbjct: 2820 I----EKMQELHAAEILDMESRHISETETLKREHYVAVQLLK 2857
Score = 34.3 bits (77), Expect = 0.46
Identities = 79/392 (20%), Positives = 157/392 (40%), Gaps = 49/392 (12%)
Query: 128 ELLTMEDEGNSDMLVVTTKAGLLELKIEKTMKEKEELLKLIAVLEKETAQLRE-QVGRME 186
++ +ED + +++ L + K+E+ ++E E L+ + KET Q E ++ ++
Sbjct: 1310 QMTNLEDIDVNHKSKLSSLQDLEKTKLEEQVQELESLISSLQQQLKETEQNYEAEIHCLQ 1369
Query: 187 RELNHEKERC--DQLQAEQKGLTEVTQSLKMENEEFKKRFSDATSK-------------- 230
+ L E L + +TE M K+ D T +
Sbjct: 1370 KRLQAVSESTVPPSLPVDSVVITESDAQRTMYPGSCVKKNIDGTIEFSGEFGVKEETNIV 1429
Query: 231 -------AHQLEEDIVSVTHK---AIEKETELDSLK-DKLKKAQHEREQLECQLKTEK-D 278
QLEE++ V A ++TEL + K A ++ CQ + +
Sbjct: 1430 KLLEKQYQEQLEEEVAKVIVSMSIAFAQQTELSRISGGKENTASSKQAHAVCQQEQHYFN 1489
Query: 279 EKELY--KVHLKNTEIENTKLMSEVQTLKNLDG--NKESVITHF-KEEIGRLQLCL---- 329
E +L ++ + E + K E + L G KE ++++ +I + C+
Sbjct: 1490 EMKLSQDQIGFQTFETVDVKFKEEFKPLSKELGEHGKEILLSNSDPHDIPESKDCVLTIS 1549
Query: 330 AEKENLQRTFLLTTSSKED----TCFLKEQLRKAEEQVQATRQEVVFLAKELSDAVN-VR 384
E + +TF++ S ++ + QL EEQ++ RQE+V +E A +R
Sbjct: 1550 EEMFSKDKTFIVRQSIHDEISVSSMDASRQLMLNEEQLEDMRQELVRQYQEHQQATELLR 1609
Query: 385 DRTMADLHTARLENEKVKKQLADAVAELKLNAMKKDQDKTDTLEHELRREVEDLKLRLQM 444
M + R + E++++++ +L + +++ E L E+E LK +L +
Sbjct: 1610 QAHMRQMERQREDQEQLQEEIKRLNRQLAQRSSIDNENLVSERERVLLEELEALK-QLSL 1668
Query: 445 AADHYKEKFKECQRLQKQINKLSDQSANNNNV 476
A + K C L+ + + + N V
Sbjct: 1669 AG-----REKLCCELRNSSTQTQNGNENQGEV 1695
Score = 30.4 bits (67), Expect = 6.7
Identities = 75/354 (21%), Positives = 133/354 (37%), Gaps = 45/354 (12%)
Query: 159 KEKEELLKLIAVLEKETAQLREQVGRMERELNHEKERCDQLQAEQKGLTEVTQSLKMENE 218
+E + L + V+ E L +QV E+ K + + LT+ SLK E E
Sbjct: 2371 EEADSLKHQLDVVIAEKLALEQQVETANEEMTFMKNVLKETNFKMNQLTQELFSLKRERE 2430
Query: 219 EFKKRFS----------DATSK-AHQLEEDIVSVTHKAIEKETELDSLKDKLKKAQHERE 267
+K S D SK +LE + K++E +T S ++ K + E
Sbjct: 2431 SVEKIQSIPENSVNVAIDHLSKDKPELEVVLTEDALKSLENQTYFKSFEENGKGSIINLE 2490
Query: 268 QLECQLKTEKDEKEL--------YKVHLKNTEIENTKLMSEVQTLKNLDGNKESVITHFK 319
QL++ K+L K + + E L ++ L+ + K + +
Sbjct: 2491 TRLLQLESTVSAKDLELTQCYKQIKDMQEQGQFETEMLQKKIVNLQKIVEEKVAAALVSQ 2550
Query: 320 EEIGRLQ----LCL--------AEKENLQRTFLLTTSS-KEDTCFLKEQLRKAEEQVQAT 366
++ +Q C E+ N+Q L D L ++ + E QV
Sbjct: 2551 IQLEAVQEYAKFCQDNQTISSEPERTNIQNLNQLREDELGSDISALTLRISELESQVVEM 2610
Query: 367 RQEVVFLAKELSDA-VNVRDRTMADLHTARL-------ENEKVKKQLADAVAELKLNAMK 418
++ +++ A NV ++ L +L + EK KK+ V LK
Sbjct: 2611 HTSLILEKEQVEIAEKNVLEKEKKLLELQKLLEGNEKKQREKEKKRSPQDVEVLKTTTEL 2670
Query: 419 KDQDKTDTLEHELRR-EVEDLKLRLQMAADHYKEKFKECQR--LQKQINKLSDQ 469
++ +EL E + + ++A+ YKEK ++ Q L K+ N S Q
Sbjct: 2671 FHSNEESGFFNELEALRAESVATKAELAS--YKEKAEKLQEELLVKETNMTSLQ 2722
>gi|34878904 synaptonemal complex protein 1 [Homo sapiens]
Length = 976
Score = 88.6 bits (218), Expect = 2e-17
Identities = 120/526 (22%), Positives = 215/526 (40%), Gaps = 82/526 (15%)
Query: 151 ELKIEKTMKEKEELLKLIAVLEKETA---------QLREQVGRMERELNHEKERCDQLQA 201
E K E KEK+ L LI + EKE + R++V ++E + + E Q
Sbjct: 256 EYKKEINDKEKQVSLLLIQITEKENKMKDLTFLLEESRDKVNQLEEKTKLQSENLKQSIE 315
Query: 202 EQKGLTEVTQSLKMENEEFKKRFSDATSKAHQLEEDIVSVTHKAIEKETELDSLKDKLKK 261
+Q LT+ + +K+ + S +T KA LEED+ T + E ++ ++ K
Sbjct: 316 KQHHLTKELEDIKVSLQR-----SVSTQKA--LEEDLQIATKTICQLTEEKETQMEESNK 368
Query: 262 AQHERE-----------QLECQLKTEKDEKELYKVHLKNTEIENTKLMSEVQTLKNLDGN 310
A+ LE L+TE+ E + LK +E K SE++ + L N
Sbjct: 369 ARAAHSFVVTEFETTVCSLEELLRTEQQRLEKNEDQLKILTMELQKKSSELEEMTKLTNN 428
Query: 311 KESVITHFKEEIGRLQLCLAEKENL-----------QRTFLLTTSSKEDTCFLKEQLRKA 359
KE + K+ +G + L E + Q L + +++ L+ QL
Sbjct: 429 KEVELEELKKVLGEKETLLYENKQFEKIAEELKGTEQELIGLLQAREKEVHDLEIQLTAI 488
Query: 360 EEQVQATRQEVVFLAKELSDAVNVRDRTMADLHTARLENEKVKKQLADAVAELK-----L 414
Q +EV L EL + + + LEN+++ ++ +D ELK +
Sbjct: 489 TTSEQYYSKEVKDLKTELENEKLKNTELTSHCNKLSLENKELTQETSDMTLELKNQQEDI 548
Query: 415 NAMKKDQDK-------TDTLEHELRREVEDLKLRLQMAADHYKEKF----KECQRLQKQI 463
N KK +++ E +LR E+E ++ L+ D K K + C L+KQ+
Sbjct: 549 NNNKKQEERMLKQIENLQETETQLRNELEYVREELKQKRDEVKCKLDKSEENCNNLRKQV 608
Query: 464 ---NKLSDQSANNNNVFTKKTGNQQ--------KVNDASVNTDPA-------TSASTVDV 505
NK ++ N KK + KVN + + A T ++
Sbjct: 609 ENKNKYIEELQQENKALKKKGTAESKQLNVYEIKVNKLELELESAKQKFGEITDTYQKEI 668
Query: 506 KPSPSAAEADFDIVTKGQV-----CEMTKEIADKTE-KYNKCKQLLQDEKAKCNKYAD-- 557
+ + E + V K +V ++ KEI + + K + L++ K + +K +
Sbjct: 669 EDKKISEENLLEEVEKAKVIADEAVKLQKEIDKRCQHKIAEMVALMEKHKHQYDKIIEER 728
Query: 558 --ELAKMELKWKEQVKIAENVKLELAEVQDNYKELKRSLENPAERK 601
EL + K +EQ + ++++EL+ ++ +K+ LE E K
Sbjct: 729 DSELGLYKSKEQEQSSLRASLEIELSNLKAELLSVKKQLEIEREEK 774
Score = 70.5 bits (171), Expect = 6e-12
Identities = 110/489 (22%), Positives = 211/489 (43%), Gaps = 65/489 (13%)
Query: 150 LELKIEKTMKEKEELLK-------LIAVLEKETAQLREQVGRMERE----------LNHE 192
+ LK+E+ ++E ++L+K L +L++ A+ E+ + E E LN+
Sbjct: 158 VSLKLEEGIQENKDLIKENNATRHLCNLLKETCARSAEKTKKYEYEREETRQVYMDLNNN 217
Query: 193 KERCD------QLQAEQKGLT------EVTQSLKMENEEFKKRFSDATSKAHQLEEDIVS 240
E+ ++QAE L E + ++ +E+KK +D K Q+ ++
Sbjct: 218 IEKMITAFEELRVQAENSRLEMHFKLKEDYEKIQHLEQEYKKEIND---KEKQVSLLLIQ 274
Query: 241 VTHKAIEKETELDSLKDKLKKAQHEREQLE--CQLKTEKDEKELYKVHLKNTEIENTK-- 296
+T EKE ++ L L++++ + QLE +L++E ++ + K H E+E+ K
Sbjct: 275 IT----EKENKMKDLTFLLEESRDKVNQLEEKTKLQSENLKQSIEKQHHLTKELEDIKVS 330
Query: 297 LMSEVQTLKNLDGNKE---SVITHFKEEIGRLQLCLAEKENLQRTFLLTTSSKEDTCFLK 353
L V T K L+ + + I EE Q+ + K +F++ T + C L+
Sbjct: 331 LQRSVSTQKALEEDLQIATKTICQLTEE-KETQMEESNKARAAHSFVV-TEFETTVCSLE 388
Query: 354 EQLRKAEEQVQATRQEVVFLAKELSDAVNVRDRTMADLHTARLENEKVKKQLADAVAELK 413
E LR +++++ ++ L EL + + + +E E++KK L + L
Sbjct: 389 ELLRTEQQRLEKNEDQLKILTMELQKKSSELEEMTKLTNNKEVELEELKKVLGEKETLLY 448
Query: 414 LN-AMKKDQDKTDTLEHEL-----RREVEDLKLRLQMAADHYKEKFKECQRLQKQINKLS 467
N +K ++ E EL RE E L +Q+ A E++ K++ L
Sbjct: 449 ENKQFEKIAEELKGTEQELIGLLQAREKEVHDLEIQLTAITTSEQY-----YSKEVKDLK 503
Query: 468 DQSANNNNVFTKKTGNQQKVNDASVNTDPATSASTVDVKPSPSAAEADFDIVTKGQVCEM 527
+ N T+ T + K++ + TS T+++K + K Q M
Sbjct: 504 TELENEKLKNTELTSHCNKLSLENKELTQETSDMTLELKNQQEDINNN-----KKQEERM 558
Query: 528 TKEIAD----KTEKYNKCKQLLQDEKAKCNKYADELAKMELKWKEQVKIAENVKLELAEV 583
K+I + +T+ N+ + + ++ K K ++ +L K E K EN + E+
Sbjct: 559 LKQIENLQETETQLRNELEYVREELKQKRDEVKCKLDKSEENCNNLRKQVENKNKYIEEL 618
Query: 584 QDNYKELKR 592
Q K LK+
Sbjct: 619 QQENKALKK 627
Score = 62.0 bits (149), Expect = 2e-09
Identities = 91/406 (22%), Positives = 156/406 (38%), Gaps = 89/406 (21%)
Query: 211 QSLKMENEEFKKRFSDATSKAHQLEEDIVSVTHKAIEKETELDSLKDKLKKAQHEREQLE 270
+ LK + E + S SK ++ E I K + TE + L+ K K Q R+ +E
Sbjct: 89 EGLKDSDLENSEGLSRVYSKLYKEAEKI-----KKWKVSTEAE-LRQKESKLQENRKIIE 142
Query: 271 CQLKTEKDEKELYKVHLKNTEIENTKLMSEVQTLKNLDGNKESVITHFKEEIGRLQLCLA 330
Q K + ++ N ++ + KL +Q K+L KE LC
Sbjct: 143 AQ------RKAIQELQFGNEKV-SLKLEEGIQENKDL----------IKENNATRHLCNL 185
Query: 331 EKENLQRTFLLTTSSKEDTCFLKEQLRKAEEQVQATRQEVVFLAKELSDAVNVRDRTMAD 390
KE R+ E+ +K E + + TRQ + L + + +
Sbjct: 186 LKETCARS--------------AEKTKKYEYEREETRQVYMDLNNNIEKMITAFEELRVQ 231
Query: 391 LHTARLENEKVKKQLADAVAELKLNAMKKDQDKTDTLEHELRREVEDLKLRLQMAADHYK 450
+RLE KL K+D +K LE E ++E+ D + ++ +
Sbjct: 232 AENSRLE------------MHFKL---KEDYEKIQHLEQEYKKEINDKEKQVSLLLIQIT 276
Query: 451 EKFKECQRLQKQINKLSDQSANNNNVFTKKTGNQQKVNDASVNTDPATSASTVDVKPS-- 508
EK + K + L ++S + N +KT Q + S+ + D+K S
Sbjct: 277 EK----ENKMKDLTFLLEESRDKVNQLEEKTKLQSENLKQSIEKQHHLTKELEDIKVSLQ 332
Query: 509 -----PSAAEADFDIVTKGQVCEMTKEIADKTEKYNKCK------------------QLL 545
A E D I TK +C++T+E + E+ NK + +LL
Sbjct: 333 RSVSTQKALEEDLQIATK-TICQLTEEKETQMEESNKARAAHSFVVTEFETTVCSLEELL 391
Query: 546 QDEKAKCNKYAD-------ELAKMELKWKEQVKIAENVKLELAEVQ 584
+ E+ + K D EL K + +E K+ N ++EL E++
Sbjct: 392 RTEQQRLEKNEDQLKILTMELQKKSSELEEMTKLTNNKEVELEELK 437
Score = 60.5 bits (145), Expect = 6e-09
Identities = 88/340 (25%), Positives = 155/340 (45%), Gaps = 44/340 (12%)
Query: 153 KIEKTMKEKE-ELLKLIAVLEKETAQLREQVGRMER-ELNHEKERCD---QLQAEQKGLT 207
KI + +K E EL+ L+ EKE L Q+ + E + KE D +L+ E+ T
Sbjct: 455 KIAEELKGTEQELIGLLQAREKEVHDLEIQLTAITTSEQYYSKEVKDLKTELENEKLKNT 514
Query: 208 EVTQ---SLKMENEEFKKRFSDATSKAHQLEEDI----------VSVTHKAIEKET---- 250
E+T L +EN+E + SD T + +EDI + E ET
Sbjct: 515 ELTSHCNKLSLENKELTQETSDMTLELKNQQEDINNNKKQEERMLKQIENLQETETQLRN 574
Query: 251 ELDSLKDKLKKAQHEREQLECQL-KTEKDEKELYK-VHLKNTEIENTKLMSEVQTLKNLD 308
EL+ ++++LK+ +R++++C+L K+E++ L K V KN IE +L E + LK
Sbjct: 575 ELEYVREELKQ---KRDEVKCKLDKSEENCNNLRKQVENKNKYIE--ELQQENKALKKKG 629
Query: 309 GNKESVITHFKEEIGRLQLCLAEKENLQRTF--LLTTSSK--EDTCFLKEQLRKAEEQVQ 364
+ + ++ ++ +L+L E E+ ++ F + T K ED +E L + E+ +
Sbjct: 630 TAESKQLNVYEIKVNKLEL---ELESAKQKFGEITDTYQKEIEDKKISEENLLEEVEKAK 686
Query: 365 ATRQEVVFLAKELSDAVNVRDRTMADLHTARLENEKVKKQLADAVAE--LKLNAMKKDQD 422
E V L KE+ + M L EK K Q + E +L K +
Sbjct: 687 VIADEAVKLQKEIDKRCQHKIAEMVAL------MEKHKHQYDKIIEERDSELGLYKSKEQ 740
Query: 423 KTDTLEHELRREVEDLKLRLQMAADHYKEKFKECQRLQKQ 462
+ +L L E+ +LK L + + +E ++L+++
Sbjct: 741 EQSSLRASLEIELSNLKAELLSVKKQLEIEREEKEKLKRE 780
Score = 59.3 bits (142), Expect = 1e-08
Identities = 120/567 (21%), Positives = 227/567 (40%), Gaps = 101/567 (17%)
Query: 122 ASSPVEELLTMEDEGNSDMLVVTTKAGLLELKIE----------KTMKEKEELLKLIAVL 171
A V L +E GNSD + GL + +E K KE E++ K
Sbjct: 67 ALQKVNFLPVLEQVGNSDCHY---QEGLKDSDLENSEGLSRVYSKLYKEAEKIKKWKVST 123
Query: 172 EKETAQLREQVGRMERELNHEKERCDQLQAEQKGLTEVTQSLKMENEEFKKRFSDATSKA 231
E A+LR++ +++ E ++A++K + Q L+ NE+ + + +
Sbjct: 124 E---AELRQKESKLQ-------ENRKIIEAQRKAI----QELQFGNEKVSLKLEEGIQEN 169
Query: 232 HQLEEDIVSVTHKA-IEKETELDSLKDKLKKAQHEREQ-------LECQLKTEKDEKELY 283
L ++ + H + KET S +K KK ++ERE+ L ++ E
Sbjct: 170 KDLIKENNATRHLCNLLKETCARS-AEKTKKYEYEREETRQVYMDLNNNIEKMITAFEEL 228
Query: 284 KVHLKNTEIE-NTKLMSEVQTLKNLDGNKESVITHFKEEIGRLQLCLAEKENLQR--TFL 340
+V +N+ +E + KL + + +++L+ + I ++++ L + + EKEN + TFL
Sbjct: 229 RVQAENSRLEMHFKLKEDYEKIQHLEQEYKKEINDKEKQVSLLLIQITEKENKMKDLTFL 288
Query: 341 LTTSS------KEDTCFLKEQLR----------KAEEQVQATRQEVVFLAKELSDAVNVR 384
L S +E T E L+ K E ++ + Q V K L + + +
Sbjct: 289 LEESRDKVNQLEEKTKLQSENLKQSIEKQHHLTKELEDIKVSLQRSVSTQKALEEDLQIA 348
Query: 385 DRTMADL----HTARLENEKVKKQLADAVAELKLNA-------------MKKDQDKTDTL 427
+T+ L T E+ K + + V E + ++K++D+ L
Sbjct: 349 TKTICQLTEEKETQMEESNKARAAHSFVVTEFETTVCSLEELLRTEQQRLEKNEDQLKIL 408
Query: 428 EHELRR------EVEDLKLRLQMAADHYKEKFKECQRL---QKQINKLSDQ-SANNNNVF 477
EL++ E+ L ++ + K+ E + L KQ K++++ +
Sbjct: 409 TMELQKKSSELEEMTKLTNNKEVELEELKKVLGEKETLLYENKQFEKIAEELKGTEQELI 468
Query: 478 TKKTGNQQKVNDASVNTDPATSASTVDVKPSPSAAEADFDIVTKGQVCEMTKEIADKTEK 537
+++V+D + T+ +E + K E+ E TE
Sbjct: 469 GLLQAREKEVHDLEIQLTAITT------------SEQYYSKEVKDLKTELENEKLKNTEL 516
Query: 538 YNKCKQLLQDEKAKCNKYADELAKMELKWKEQVKIAENVKLE--LAEVQDNYKELKRSLE 595
+ C +L + K + +D +ELK +Q I N K E + + +N +E + L
Sbjct: 517 TSHCNKLSLENKELTQETSD--MTLELK-NQQEDINNNKKQEERMLKQIENLQETETQLR 573
Query: 596 NPAE--RKMEGQNSQSPQCFKTCSEQN 620
N E R+ Q +C SE+N
Sbjct: 574 NELEYVREELKQKRDEVKCKLDKSEEN 600
>gi|56550047 uveal autoantigen with coiled-coil domains and ankyrin
repeats isoform 2 [Homo sapiens]
Length = 1403
Score = 88.2 bits (217), Expect = 3e-17
Identities = 132/579 (22%), Positives = 242/579 (41%), Gaps = 123/579 (21%)
Query: 134 DEGNSDMLVVTTKAGLLELKIEKTMKEKEELLKLIAVLE----------KETAQLREQVG 183
D+ N +L VT K +L++EK + E + L K ++ LE KE L+ +
Sbjct: 749 DDLNRKLLDVTQKYTEKKLEMEKLLLENDSLSKDVSRLETVFVPPEKHEKEIIALKSNIV 808
Query: 184 RMERELNHEKERCDQLQAEQKGLTEVTQSLK--MEN--------EEFKKRFSDATSKAHQ 233
++++L+ K++C + Q + LT +LK M N EE K +D +K ++
Sbjct: 809 ELKKQLSELKKKCGEDQEKIHALTSENTNLKKMMSNQYVPVKTHEEVKMTLNDTLAKTNR 868
Query: 234 LEEDIVSVTHKAIEKETELDSLKDKLKKAQHEREQLECQLKTEKDEKELYKVHLKNTEIE 293
+++ V K + E +KDK + + E + Q+K E ++ + +
Sbjct: 869 ---ELLDVKKKFEDINQEFVKIKDKNEILKRNLENTQNQIKAEYISLAEHEAKMSSLSQS 925
Query: 294 NTKLM-SEVQTLKNLDGNKESVITHF------KEEIGRLQLCLAEK-------ENLQRTF 339
K+ S + L N +E ++T K+E+ +Q C+ K E +R F
Sbjct: 926 MRKVQDSNAEILANYRKGQEEIVTLHAEIKAQKKELDTIQECIKVKYAPIVSFEECERKF 985
Query: 340 LLTTSSKEDTCFLKEQLRK---AEEQVQATRQEVVFLAKELSDAV-NVRDRTMADLHTAR 395
T +D L EQ +K +EE+V+ +QE L KE+ ++RD+T+ +
Sbjct: 986 KATEKELKDQ--LSEQTQKYSVSEEEVKKNKQENDKLKKEIFTLQKDLRDKTVLIEKSHE 1043
Query: 396 LEN------EKVKKQLADA------VAELKLNAMKKDQDKTDTL---------EHELRRE 434
+E +++ KQL D V +K ++++ +T + +H +
Sbjct: 1044 MERALSRKTDELNKQLKDLSQKYTEVKNVKEKLVEENAKQTSEILAVQNLLQKQHVPLEQ 1103
Query: 435 VEDLKLRLQMAADHYKEKFKECQRL----QKQINKLSDQSANNNN-------------VF 477
VE LK L ++ KE+ K QR Q+ + KL N N F
Sbjct: 1104 VEALKKSLNGTIENLKEELKSMQRCYEKEQQTVTKLHQLLENQKNSSVPLAEHLQIKEAF 1163
Query: 478 TKKTG------------NQQKVNDASV------NTDPAT----SASTVDV---KPSPSAA 512
K+ G +Q K+ + S NT A + VD+ K + S
Sbjct: 1164 EKEVGIIKASLREKEEESQNKMEEVSKLQSEVQNTKQALKKLETREVVDLSKYKATKSDL 1223
Query: 513 EADFDIVTKG---------QVCEMT-----KEIADKTEK---YNKCKQLLQDEKAKCNKY 555
E + + +VCE KEI+ K EK + +Q ++D+K +C+K
Sbjct: 1224 ETQISSLNEKLANLNRKYEEVCEEVLHAKKKEISAKDEKELLHFSIEQEIKDQKERCDKS 1283
Query: 556 ADELAKMELKWKEQVKIAENVKLELAEVQDNYKELKRSL 594
+ +++ + +E K E ++ E+ ++ + LK++L
Sbjct: 1284 LTTITELQRRIQESAKQIEAKDNKITELLNDVERLKQAL 1322
Score = 65.1 bits (157), Expect = 2e-10
Identities = 92/553 (16%), Positives = 232/553 (41%), Gaps = 72/553 (13%)
Query: 144 TTKAGLLELKIEKTMKEKEELLKLIAVLEKETAQLREQVGRMERELNHEKERCDQLQAEQ 203
+ + G L +I++ EE + L +E +L++++ E E + + +++ +
Sbjct: 544 SAEVGKLRNQIKQNEMIVEEFKRDEGKLIEENKRLQKELSMCEMEREKKGRKVTEMEGQA 603
Query: 204 KGLTEVTQSLKMENEEFKKRFSDATSKAHQLEEDIVSVTHKAIEKETELDSLKDKL---- 259
K L+ +L + E+F+ S +++ ++ + +V + + + +E+ LK +L
Sbjct: 604 KELS-AKLALSIPAEKFENMKSSLSNEVNEKAKKLVEMEREHEKSLSEIRQLKRELENVK 662
Query: 260 -KKAQH----EREQLECQLKTEKDE--KELYKVHLKNTEIE--------NTKLMSE---- 300
K AQH E EQ++ +L+ + E K++ ++ LKN ++ + KL+ E
Sbjct: 663 AKLAQHVKPEEHEQVKSRLEQKSGELGKKITELTLKNQTLQKEIEKVYLDNKLLKEQAHN 722
Query: 301 -----------VQTLKNLDGNKESVITHFKEEIGRLQLCLAEKENLQRTFLLTTSS---- 345
++ +++ + +++I ++ + EK+ LL S
Sbjct: 723 LTIEMKNHYVPLKVSEDMKKSHDAIIDDLNRKLLDVTQKYTEKKLEMEKLLLENDSLSKD 782
Query: 346 --KEDTCFLKEQLRKAEEQVQATRQEVVFLAKELSDAVNVRDRTMADLHTARLENEKVKK 403
+ +T F+ + K E+++ A + +V L K+LS+ +H EN +KK
Sbjct: 783 VSRLETVFVPPE--KHEKEIIALKSNIVELKKQLSELKKKCGEDQEKIHALTSENTNLKK 840
Query: 404 QLADAVAELKLN-----AMKKDQDKTDTLEHELRREVEDLKLRLQMAADHYKEKFKECQR 458
+++ +K + + KT+ +++++ ED+ D + + +
Sbjct: 841 MMSNQYVPVKTHEEVKMTLNDTLAKTNRELLDVKKKFEDINQEFVKIKDKNEILKRNLEN 900
Query: 459 LQKQINKLSDQSANNNNVFTKKTGNQQKVNDASV-----------------------NTD 495
Q QI A + + + + +KV D++ +
Sbjct: 901 TQNQIKAEYISLAEHEAKMSSLSQSMRKVQDSNAEILANYRKGQEEIVTLHAEIKAQKKE 960
Query: 496 PATSASTVDVKPSPSAAEADFDIVTKGQVCEMTKEIADKTEKYNKCKQLLQDEKAKCNKY 555
T + VK +P + + + K E+ +++++T+KY+ ++ ++ K + +K
Sbjct: 961 LDTIQECIKVKYAPIVSFEECERKFKATEKELKDQLSEQTQKYSVSEEEVKKNKQENDKL 1020
Query: 556 ADELAKMELKWKEQVKIAENVKLELAEVQDNYKELKRSLENPAERKMEGQNSQSPQCFKT 615
E+ ++ +++ + E + EL + L++ +++ E +N + + +
Sbjct: 1021 KKEIFTLQKDLRDKTVLIEKSHEMERALSRKTDELNKQLKDLSQKYTEVKNVKE-KLVEE 1079
Query: 616 CSEQNGYVLTLSN 628
++Q +L + N
Sbjct: 1080 NAKQTSEILAVQN 1092
Score = 64.7 bits (156), Expect = 3e-10
Identities = 89/429 (20%), Positives = 169/429 (39%), Gaps = 81/429 (18%)
Query: 146 KAGLLELKIEKTMKEKEELLKLIAVLEKETAQLREQVGRMERELNHEKERCDQLQAEQKG 205
K L + K E+L ++E L ++ ++EL+ +E A
Sbjct: 918 KMSSLSQSMRKVQDSNAEILANYRKGQEEIVTLHAEIKAQKKELDTIQECIKVKYAPIVS 977
Query: 206 LTEVTQSLKMENEEFKKRFSDATSKAHQLEEDIVSVTHKAIEKETELDSLKDKLK----- 260
E + K +E K + S+ T K EE++ + + + E+ +L+ L+
Sbjct: 978 FEECERKFKATEKELKDQLSEQTQKYSVSEEEVKKNKQENDKLKKEIFTLQKDLRDKTVL 1037
Query: 261 -KAQHEREQLECQLKTEKDEKELYKVHLKNTEI---------ENTKLMSEVQTLKNL--- 307
+ HE E+ KT++ K+L + K TE+ EN K SE+ ++NL
Sbjct: 1038 IEKSHEMER-ALSRKTDELNKQLKDLSQKYTEVKNVKEKLVEENAKQTSEILAVQNLLQK 1096
Query: 308 --------DGNKESV---ITHFKEEIGRLQLCLAEKEN------------------LQRT 338
+ K+S+ I + KEE+ +Q C +++ L
Sbjct: 1097 QHVPLEQVEALKKSLNGTIENLKEELKSMQRCYEKEQQTVTKLHQLLENQKNSSVPLAEH 1156
Query: 339 FLLTTSSKEDTCFLKEQLRKAEEQVQATRQEVVFLAKELSDA----VNVRDRTMADLHTA 394
+ + +++ +K LR+ EE+ Q +EV L E+ + + R + DL
Sbjct: 1157 LQIKEAFEKEVGIIKASLREKEEESQNKMEEVSKLQSEVQNTKQALKKLETREVVDLSKY 1216
Query: 395 RLENEKVKKQLA-------------DAVAELKLNAMKKD---QDKTDTLEHELRREVEDL 438
+ ++ Q++ + V E L+A KK+ +D+ + L + +E++D
Sbjct: 1217 KATKSDLETQISSLNEKLANLNRKYEEVCEEVLHAKKKEISAKDEKELLHFSIEQEIKDQ 1276
Query: 439 KLRLQMAADHYKEKFKECQRLQKQI----NKLSD---------QSANNNNVFTKKTGNQQ 485
K R + E + Q KQI NK+++ Q+ N + T +GN
Sbjct: 1277 KERCDKSLTTITELQRRIQESAKQIEAKDNKITELLNDVERLKQALNGLSQLTYTSGNPT 1336
Query: 486 KVNDASVNT 494
K ++T
Sbjct: 1337 KRQSQLIDT 1345
Score = 60.5 bits (145), Expect = 6e-09
Identities = 89/476 (18%), Positives = 203/476 (42%), Gaps = 60/476 (12%)
Query: 149 LLELKIEKTMKEKEELLKLIAVLEKETAQLREQVGRMERELNHE------------KERC 196
LL+ E T K +E K ++ ++ ++++V + H+ KER
Sbjct: 238 LLKTASENTNKGRELWKKGPSLQQRNLTHMQDEVNVKSHQREHQNIQDLEIENEDLKERL 297
Query: 197 DQLQAEQKGLTEVTQSLKMENEEFKKRFSDATSKAHQLEEDIVSVTHKAIEKETELDSLK 256
++Q EQ+ L + L+++ E D S+ +L+ + + + E +++LK
Sbjct: 298 RKIQQEQRILLDKVNGLQLQLNEEVMVADDLESEREKLKSLLAAKEKQHEESLRTIEALK 357
Query: 257 DKLKKAQHEREQLECQLKTEKDEKELYK--VHLKNTEIENTKLMSEVQT---LKNLDGNK 311
++ K + + K++ L + +++ +++ + + + +Q+ L+ L+ +
Sbjct: 358 NRFKYFESDHLGSGSHFSNRKEDMLLKQGQMYMADSQCTSPGIPAHMQSRSMLRPLELSL 417
Query: 312 ESVITHFKEEIGRLQLCLAEKENLQRTFLLTTSSKEDTCFLKEQLRKAEEQVQATRQEVV 371
S ++ + EI + +L RTF S+K+D L+ +L + +A E
Sbjct: 418 PSQTSYSENEILKKEL------EAMRTFC--ESAKQDRLKLQNELAHKVAECKALALECE 469
Query: 372 FLAKELSDAVNVRDRTMADLHTARLENEKVKKQLADAVAELKLNAMKKDQDKTDTLEHEL 431
+ ++ + + + + D+ E+E KQ+ LK + + L EL
Sbjct: 470 RVKEDSDEQIKQLEDALKDVQKRMYESEGKVKQMQTHFLALKEHLTSEAASGNHRLTEEL 529
Query: 432 RREVEDLKLRLQMAADHYKEKFKECQRLQKQINKLSDQSANNNNVFTKKTGNQQKVNDAS 491
+ +++DLK++ + A+ ++ KL +Q N + + ++ K+ + +
Sbjct: 530 KDQLKDLKVKYEGAS--------------AEVGKLRNQIKQNEMIVEEFKRDEGKLIEEN 575
Query: 492 VNTDPATSASTVD-VKPSPSAAEADFDIVTKGQVCEMTKEIA--DKTEKYNKCKQLLQDE 548
S ++ K E + GQ E++ ++A EK+ K L +E
Sbjct: 576 KRLQKELSMCEMEREKKGRKVTEME------GQAKELSAKLALSIPAEKFENMKSSLSNE 629
Query: 549 KAKCNKYADELAKMELKWKEQV-------KIAENVKLELAE--VQDNYKELKRSLE 595
N+ A +L +ME + ++ + + ENVK +LA+ + ++++K LE
Sbjct: 630 ---VNEKAKKLVEMEREHEKSLSEIRQLKRELENVKAKLAQHVKPEEHEQVKSRLE 682
>gi|59850762 uveal autoantigen with coiled-coil domains and ankyrin
repeats isoform 1 [Homo sapiens]
Length = 1416
Score = 88.2 bits (217), Expect = 3e-17
Identities = 132/579 (22%), Positives = 242/579 (41%), Gaps = 123/579 (21%)
Query: 134 DEGNSDMLVVTTKAGLLELKIEKTMKEKEELLKLIAVLE----------KETAQLREQVG 183
D+ N +L VT K +L++EK + E + L K ++ LE KE L+ +
Sbjct: 762 DDLNRKLLDVTQKYTEKKLEMEKLLLENDSLSKDVSRLETVFVPPEKHEKEIIALKSNIV 821
Query: 184 RMERELNHEKERCDQLQAEQKGLTEVTQSLK--MEN--------EEFKKRFSDATSKAHQ 233
++++L+ K++C + Q + LT +LK M N EE K +D +K ++
Sbjct: 822 ELKKQLSELKKKCGEDQEKIHALTSENTNLKKMMSNQYVPVKTHEEVKMTLNDTLAKTNR 881
Query: 234 LEEDIVSVTHKAIEKETELDSLKDKLKKAQHEREQLECQLKTEKDEKELYKVHLKNTEIE 293
+++ V K + E +KDK + + E + Q+K E ++ + +
Sbjct: 882 ---ELLDVKKKFEDINQEFVKIKDKNEILKRNLENTQNQIKAEYISLAEHEAKMSSLSQS 938
Query: 294 NTKLM-SEVQTLKNLDGNKESVITHF------KEEIGRLQLCLAEK-------ENLQRTF 339
K+ S + L N +E ++T K+E+ +Q C+ K E +R F
Sbjct: 939 MRKVQDSNAEILANYRKGQEEIVTLHAEIKAQKKELDTIQECIKVKYAPIVSFEECERKF 998
Query: 340 LLTTSSKEDTCFLKEQLRK---AEEQVQATRQEVVFLAKELSDAV-NVRDRTMADLHTAR 395
T +D L EQ +K +EE+V+ +QE L KE+ ++RD+T+ +
Sbjct: 999 KATEKELKDQ--LSEQTQKYSVSEEEVKKNKQENDKLKKEIFTLQKDLRDKTVLIEKSHE 1056
Query: 396 LEN------EKVKKQLADA------VAELKLNAMKKDQDKTDTL---------EHELRRE 434
+E +++ KQL D V +K ++++ +T + +H +
Sbjct: 1057 MERALSRKTDELNKQLKDLSQKYTEVKNVKEKLVEENAKQTSEILAVQNLLQKQHVPLEQ 1116
Query: 435 VEDLKLRLQMAADHYKEKFKECQRL----QKQINKLSDQSANNNN-------------VF 477
VE LK L ++ KE+ K QR Q+ + KL N N F
Sbjct: 1117 VEALKKSLNGTIENLKEELKSMQRCYEKEQQTVTKLHQLLENQKNSSVPLAEHLQIKEAF 1176
Query: 478 TKKTG------------NQQKVNDASV------NTDPAT----SASTVDV---KPSPSAA 512
K+ G +Q K+ + S NT A + VD+ K + S
Sbjct: 1177 EKEVGIIKASLREKEEESQNKMEEVSKLQSEVQNTKQALKKLETREVVDLSKYKATKSDL 1236
Query: 513 EADFDIVTKG---------QVCEMT-----KEIADKTEK---YNKCKQLLQDEKAKCNKY 555
E + + +VCE KEI+ K EK + +Q ++D+K +C+K
Sbjct: 1237 ETQISSLNEKLANLNRKYEEVCEEVLHAKKKEISAKDEKELLHFSIEQEIKDQKERCDKS 1296
Query: 556 ADELAKMELKWKEQVKIAENVKLELAEVQDNYKELKRSL 594
+ +++ + +E K E ++ E+ ++ + LK++L
Sbjct: 1297 LTTITELQRRIQESAKQIEAKDNKITELLNDVERLKQAL 1335
Score = 65.1 bits (157), Expect = 2e-10
Identities = 92/553 (16%), Positives = 232/553 (41%), Gaps = 72/553 (13%)
Query: 144 TTKAGLLELKIEKTMKEKEELLKLIAVLEKETAQLREQVGRMERELNHEKERCDQLQAEQ 203
+ + G L +I++ EE + L +E +L++++ E E + + +++ +
Sbjct: 557 SAEVGKLRNQIKQNEMIVEEFKRDEGKLIEENKRLQKELSMCEMEREKKGRKVTEMEGQA 616
Query: 204 KGLTEVTQSLKMENEEFKKRFSDATSKAHQLEEDIVSVTHKAIEKETELDSLKDKL---- 259
K L+ +L + E+F+ S +++ ++ + +V + + + +E+ LK +L
Sbjct: 617 KELS-AKLALSIPAEKFENMKSSLSNEVNEKAKKLVEMEREHEKSLSEIRQLKRELENVK 675
Query: 260 -KKAQH----EREQLECQLKTEKDE--KELYKVHLKNTEIE--------NTKLMSE---- 300
K AQH E EQ++ +L+ + E K++ ++ LKN ++ + KL+ E
Sbjct: 676 AKLAQHVKPEEHEQVKSRLEQKSGELGKKITELTLKNQTLQKEIEKVYLDNKLLKEQAHN 735
Query: 301 -----------VQTLKNLDGNKESVITHFKEEIGRLQLCLAEKENLQRTFLLTTSS---- 345
++ +++ + +++I ++ + EK+ LL S
Sbjct: 736 LTIEMKNHYVPLKVSEDMKKSHDAIIDDLNRKLLDVTQKYTEKKLEMEKLLLENDSLSKD 795
Query: 346 --KEDTCFLKEQLRKAEEQVQATRQEVVFLAKELSDAVNVRDRTMADLHTARLENEKVKK 403
+ +T F+ + K E+++ A + +V L K+LS+ +H EN +KK
Sbjct: 796 VSRLETVFVPPE--KHEKEIIALKSNIVELKKQLSELKKKCGEDQEKIHALTSENTNLKK 853
Query: 404 QLADAVAELKLN-----AMKKDQDKTDTLEHELRREVEDLKLRLQMAADHYKEKFKECQR 458
+++ +K + + KT+ +++++ ED+ D + + +
Sbjct: 854 MMSNQYVPVKTHEEVKMTLNDTLAKTNRELLDVKKKFEDINQEFVKIKDKNEILKRNLEN 913
Query: 459 LQKQINKLSDQSANNNNVFTKKTGNQQKVNDASV-----------------------NTD 495
Q QI A + + + + +KV D++ +
Sbjct: 914 TQNQIKAEYISLAEHEAKMSSLSQSMRKVQDSNAEILANYRKGQEEIVTLHAEIKAQKKE 973
Query: 496 PATSASTVDVKPSPSAAEADFDIVTKGQVCEMTKEIADKTEKYNKCKQLLQDEKAKCNKY 555
T + VK +P + + + K E+ +++++T+KY+ ++ ++ K + +K
Sbjct: 974 LDTIQECIKVKYAPIVSFEECERKFKATEKELKDQLSEQTQKYSVSEEEVKKNKQENDKL 1033
Query: 556 ADELAKMELKWKEQVKIAENVKLELAEVQDNYKELKRSLENPAERKMEGQNSQSPQCFKT 615
E+ ++ +++ + E + EL + L++ +++ E +N + + +
Sbjct: 1034 KKEIFTLQKDLRDKTVLIEKSHEMERALSRKTDELNKQLKDLSQKYTEVKNVKE-KLVEE 1092
Query: 616 CSEQNGYVLTLSN 628
++Q +L + N
Sbjct: 1093 NAKQTSEILAVQN 1105
Score = 64.7 bits (156), Expect = 3e-10
Identities = 89/429 (20%), Positives = 169/429 (39%), Gaps = 81/429 (18%)
Query: 146 KAGLLELKIEKTMKEKEELLKLIAVLEKETAQLREQVGRMERELNHEKERCDQLQAEQKG 205
K L + K E+L ++E L ++ ++EL+ +E A
Sbjct: 931 KMSSLSQSMRKVQDSNAEILANYRKGQEEIVTLHAEIKAQKKELDTIQECIKVKYAPIVS 990
Query: 206 LTEVTQSLKMENEEFKKRFSDATSKAHQLEEDIVSVTHKAIEKETELDSLKDKLK----- 260
E + K +E K + S+ T K EE++ + + + E+ +L+ L+
Sbjct: 991 FEECERKFKATEKELKDQLSEQTQKYSVSEEEVKKNKQENDKLKKEIFTLQKDLRDKTVL 1050
Query: 261 -KAQHEREQLECQLKTEKDEKELYKVHLKNTEI---------ENTKLMSEVQTLKNL--- 307
+ HE E+ KT++ K+L + K TE+ EN K SE+ ++NL
Sbjct: 1051 IEKSHEMER-ALSRKTDELNKQLKDLSQKYTEVKNVKEKLVEENAKQTSEILAVQNLLQK 1109
Query: 308 --------DGNKESV---ITHFKEEIGRLQLCLAEKEN------------------LQRT 338
+ K+S+ I + KEE+ +Q C +++ L
Sbjct: 1110 QHVPLEQVEALKKSLNGTIENLKEELKSMQRCYEKEQQTVTKLHQLLENQKNSSVPLAEH 1169
Query: 339 FLLTTSSKEDTCFLKEQLRKAEEQVQATRQEVVFLAKELSDA----VNVRDRTMADLHTA 394
+ + +++ +K LR+ EE+ Q +EV L E+ + + R + DL
Sbjct: 1170 LQIKEAFEKEVGIIKASLREKEEESQNKMEEVSKLQSEVQNTKQALKKLETREVVDLSKY 1229
Query: 395 RLENEKVKKQLA-------------DAVAELKLNAMKKD---QDKTDTLEHELRREVEDL 438
+ ++ Q++ + V E L+A KK+ +D+ + L + +E++D
Sbjct: 1230 KATKSDLETQISSLNEKLANLNRKYEEVCEEVLHAKKKEISAKDEKELLHFSIEQEIKDQ 1289
Query: 439 KLRLQMAADHYKEKFKECQRLQKQI----NKLSD---------QSANNNNVFTKKTGNQQ 485
K R + E + Q KQI NK+++ Q+ N + T +GN
Sbjct: 1290 KERCDKSLTTITELQRRIQESAKQIEAKDNKITELLNDVERLKQALNGLSQLTYTSGNPT 1349
Query: 486 KVNDASVNT 494
K ++T
Sbjct: 1350 KRQSQLIDT 1358
Score = 60.5 bits (145), Expect = 6e-09
Identities = 89/476 (18%), Positives = 203/476 (42%), Gaps = 60/476 (12%)
Query: 149 LLELKIEKTMKEKEELLKLIAVLEKETAQLREQVGRMERELNHE------------KERC 196
LL+ E T K +E K ++ ++ ++++V + H+ KER
Sbjct: 251 LLKTASENTNKGRELWKKGPSLQQRNLTHMQDEVNVKSHQREHQNIQDLEIENEDLKERL 310
Query: 197 DQLQAEQKGLTEVTQSLKMENEEFKKRFSDATSKAHQLEEDIVSVTHKAIEKETELDSLK 256
++Q EQ+ L + L+++ E D S+ +L+ + + + E +++LK
Sbjct: 311 RKIQQEQRILLDKVNGLQLQLNEEVMVADDLESEREKLKSLLAAKEKQHEESLRTIEALK 370
Query: 257 DKLKKAQHEREQLECQLKTEKDEKELYK--VHLKNTEIENTKLMSEVQT---LKNLDGNK 311
++ K + + K++ L + +++ +++ + + + +Q+ L+ L+ +
Sbjct: 371 NRFKYFESDHLGSGSHFSNRKEDMLLKQGQMYMADSQCTSPGIPAHMQSRSMLRPLELSL 430
Query: 312 ESVITHFKEEIGRLQLCLAEKENLQRTFLLTTSSKEDTCFLKEQLRKAEEQVQATRQEVV 371
S ++ + EI + +L RTF S+K+D L+ +L + +A E
Sbjct: 431 PSQTSYSENEILKKEL------EAMRTFC--ESAKQDRLKLQNELAHKVAECKALALECE 482
Query: 372 FLAKELSDAVNVRDRTMADLHTARLENEKVKKQLADAVAELKLNAMKKDQDKTDTLEHEL 431
+ ++ + + + + D+ E+E KQ+ LK + + L EL
Sbjct: 483 RVKEDSDEQIKQLEDALKDVQKRMYESEGKVKQMQTHFLALKEHLTSEAASGNHRLTEEL 542
Query: 432 RREVEDLKLRLQMAADHYKEKFKECQRLQKQINKLSDQSANNNNVFTKKTGNQQKVNDAS 491
+ +++DLK++ + A+ ++ KL +Q N + + ++ K+ + +
Sbjct: 543 KDQLKDLKVKYEGAS--------------AEVGKLRNQIKQNEMIVEEFKRDEGKLIEEN 588
Query: 492 VNTDPATSASTVD-VKPSPSAAEADFDIVTKGQVCEMTKEIA--DKTEKYNKCKQLLQDE 548
S ++ K E + GQ E++ ++A EK+ K L +E
Sbjct: 589 KRLQKELSMCEMEREKKGRKVTEME------GQAKELSAKLALSIPAEKFENMKSSLSNE 642
Query: 549 KAKCNKYADELAKMELKWKEQV-------KIAENVKLELAE--VQDNYKELKRSLE 595
N+ A +L +ME + ++ + + ENVK +LA+ + ++++K LE
Sbjct: 643 ---VNEKAKKLVEMEREHEKSLSEIRQLKRELENVKAKLAQHVKPEEHEQVKSRLE 695
>gi|71061468 centromere protein E [Homo sapiens]
Length = 2701
Score = 86.3 bits (212), Expect = 1e-16
Identities = 103/502 (20%), Positives = 224/502 (44%), Gaps = 55/502 (10%)
Query: 150 LELKIEKTMKEK-EELLKLIAVLEKETA-------QLREQVGRMERELNHEKERCDQLQA 201
+++ +EK ++ E+ KL ++++ + +L ++ +++ELN E E + L+
Sbjct: 682 MQVDLEKELQSAFNEITKLTSLIDGKVPKDLLCNLELEGKITDLQKELNKEVEENEALRE 741
Query: 202 EQKGLTEVTQSLKMENEEFKKRFSDATSKAHQLEEDIVSVTHKAIEKETELDSLKDKLKK 261
E L+E+ +SL E E +K D + + H + + + + + KE+ + L +++ K
Sbjct: 742 EVILLSEL-KSLPSEVERLRKEIQDKSEELHIITSEKDKLFSEVVHKESRVQGLLEEIGK 800
Query: 262 AQHEREQLECQLKTEKDE-----------KELYKVHLKNTEIENTKLMSEVQTLKNLDGN 310
+ + + K+ E ++ YK+ L+ E N ++++ + + D +
Sbjct: 801 TKDDLATTQSNYKSTDQEFQNFKTLHMDFEQKYKMVLEENERMNQEIVNLSKEAQKFDSS 860
Query: 311 KESVITHF-------KEEIGRLQLCLAEKENLQ-----RTFLLTTSSKEDTCFLKEQLRK 358
++ T +E+ +Q L E E L+ R L T +E T + E+L++
Sbjct: 861 LGALKTELSYKTQELQEKTREVQERLNEMEQLKEQLENRDSTLQTVEREKT-LITEKLQQ 919
Query: 359 AEEQVQATRQEVVFLAKELSDAVNV-RDRTMADLHTARLENEKVKKQLADAVAELKLNAM 417
E+V+ QE L K+L +++ + RD+ +D+H N ++QL +A L ++
Sbjct: 920 TLEEVKTLTQEKDDL-KQLQESLQIERDQLKSDIHDTVNMNIDTQEQLRNA-----LESL 973
Query: 418 KKDQDKTDTLEHELRREVEDLKLRLQMAADHYKEKFKECQRLQKQINKLSDQSANNNNVF 477
K+ Q+ +TL+ ++ EV L ++ K++F Q+ I+K D A N
Sbjct: 974 KQHQETINTLKSKISEEVSR-NLHMEENTGETKDEF---QQKMVGIDKKQDLEAKNTQTL 1029
Query: 478 TKKTGNQQKVNDASVNTDPATSASTVDVKPSPSAAEADFDIVTKGQVCEMTKEIADKT-- 535
T + + + + + AE + + EMT E ++
Sbjct: 1030 TADVKDNEIIEQQRKIFSLIQEKNELQQMLESVIAEKEQLKTDLKENIEMTIENQEELRL 1089
Query: 536 --EKYNKCKQLLQDEK-------AKCNKYADELAKMELKWKEQVKIAENVKLELAEVQDN 586
++ K ++++ EK + ++ D LA++E K KE+ + + + +L VQ+
Sbjct: 1090 LGDELKKQQEIVAQEKNHAIKKEGELSRTCDRLAEVEEKLKEKSQQLQEKQQQLLNVQEE 1149
Query: 587 YKELKRSLENPAERKMEGQNSQ 608
E+++ + K E +N +
Sbjct: 1150 MSEMQKKINEIENLKNELKNKE 1171
Score = 78.6 bits (192), Expect = 2e-14
Identities = 114/503 (22%), Positives = 227/503 (45%), Gaps = 88/503 (17%)
Query: 150 LELKIEKTMKEKEELLKLIAVLEKETAQLREQVGRMERELNHEKERCDQLQAEQKGLTEV 209
L+ KI++ + EKEE + K+ ++++E+V +++ H K + LQ+ + + E+
Sbjct: 1521 LQNKIQE-IYEKEEQFNI-----KQISEVQEKVNELKQFKEHRKAKDSALQSIESKMLEL 1574
Query: 210 TQSLKMENEEFK---------KRFSDATS-KAHQLEEDIVSVTHKAIE-KETELDSLKDK 258
T L+ EE + KR +A + QL+E+ + K E +E E LK
Sbjct: 1575 TNRLQESQEEIQIMIKEKEEMKRVQEALQIERDQLKENTKEIVAKMKESQEKEYQFLK-- 1632
Query: 259 LKKAQHEREQLECQLKTEKDEKELYKVHLKNTEIENTKL-------MSEVQTLKNLDGNK 311
A +E ++ C+++ K++ E K++L+N E EN +L + E++++ +
Sbjct: 1633 -MTAVNETQEKMCEIEHLKEQFETQKLNLENIETENIRLTQILHENLEEMRSVTKERDDL 1691
Query: 312 ESVITHFKEEIGRLQLCLAEKENLQRTFLLTTSSKEDTCFLKEQLRKAEEQVQATR---- 367
SV K E +L KENL+ T +E+ + L++ +E + R
Sbjct: 1692 RSVEETLKVERDQL------KENLRETITRDLEKQEELKIVHMHLKEHQETIDKLRGIVS 1745
Query: 368 ---QEVVFLAKEL---SDAVNVRD-RTMADLHTARL---ENEKVKKQLADAVAEL--KLN 415
E+ + K+L +DA+ +D + +L A + E ++ +L V+E KL+
Sbjct: 1746 EKTNEISNMQKDLEHSNDALKAQDLKIQEELRIAHMHLKEQQETIDKLRGIVSEKTDKLS 1805
Query: 416 AMKKDQDKTDTLEHELRREVEDLK------LRLQMAADHYKEKFKECQRLQKQINKLSDQ 469
M+KD + ++ +L+ ++++LK + L+ + ++K E ++L+KQI DQ
Sbjct: 1806 NMQKDLENSNA---KLQEKIQELKANEHQLITLKKDVNETQKKVSEMEQLKKQIK---DQ 1859
Query: 470 SANNNNVFTKKTGNQQKVNDASVNTDPATSASTVDVKPSPSAAEADFDIVTKGQVCEMTK 529
S + + + QK+++ N + S V K +
Sbjct: 1860 SLTLSKLEIENLNLAQKLHE---NLEEMKS-------------------VMKERDNLRRV 1897
Query: 530 EIADKTEKYNKCKQLLQDEKAKCNKYADELAKMELKWKEQV----KIAENVKLELAEVQD 585
E K E+ ++ K+ LQ+ KA+ + EL + KE K+ E + + ++ D
Sbjct: 1898 EETLKLER-DQLKESLQETKARDLEIQQELKTARMLSKEHKETVDKLREKISEKTIQISD 1956
Query: 586 NYKELKRSLENPAERKMEGQNSQ 608
K+L +S + ++ E Q +
Sbjct: 1957 IQKDLDKSKDELQKKIQELQKKE 1979
Score = 75.1 bits (183), Expect = 2e-13
Identities = 95/490 (19%), Positives = 221/490 (45%), Gaps = 50/490 (10%)
Query: 158 MKEKE-ELLKLIAVLE----KETAQLREQVGRM--ERELNHEKERCDQLQAEQKGLTEVT 210
MKEK+ E K+++ +E K++A LR ++ + + L + + E+ L +
Sbjct: 1392 MKEKDNETTKIVSEMEQFKPKDSALLRIEIEMLGLSKRLQESHDEMKSVAKEKDDLQRLQ 1451
Query: 211 QSLKMENEEFKKRFSDATSKAHQLEEDIVSVTHKAI---------------EKETELDSL 255
+ L+ E+++ K+ + +K + EE++ V H + EKETE+ ++
Sbjct: 1452 EVLQSESDQLKENIKEIVAKHLETEEEL-KVAHCCLKEQEETINELRVNLSEKETEISTI 1510
Query: 256 KDKLKKAQHEREQLECQLKTEKDE----KELYKVHLKNTEIENTK--LMSEVQTLKNLDG 309
+ +L +A +++ Q + Q EK+E K++ +V K E++ K ++ L++++
Sbjct: 1511 QKQL-EAINDKLQNKIQEIYEKEEQFNIKQISEVQEKVNELKQFKEHRKAKDSALQSIES 1569
Query: 310 NKESVITHFKEEIGRLQLCLAEKENLQRT--------FLLTTSSKEDTCFLKEQLRKAEE 361
+ +E +Q+ + EKE ++R L ++KE +KE K +
Sbjct: 1570 KMLELTNRLQESQEEIQIMIKEKEEMKRVQEALQIERDQLKENTKEIVAKMKESQEKEYQ 1629
Query: 362 QVQAT----RQEVVFLAKELSDAVNVRDRTMADLHTARLENEKVKKQLADAVAELKLNAM 417
++ T QE + + L + + + ++ T EN ++ + L + + E++ ++
Sbjct: 1630 FLKMTAVNETQEKMCEIEHLKEQFETQKLNLENIET---ENIRLTQILHENLEEMR--SV 1684
Query: 418 KKDQDKTDTLEHELRREVEDLKLRLQMAADHYKEKFKECQRLQKQINKLSDQSANNNNVF 477
K++D ++E L+ E + LK L+ EK +E + + + + + +
Sbjct: 1685 TKERDDLRSVEETLKVERDQLKENLRETITRDLEKQEELKIVHMHLKEHQETIDKLRGIV 1744
Query: 478 TKKTGNQQKVNDASVNTDPATSASTVDVKPSPSAAEADFDIVTKGQVCEMTKEI-ADKTE 536
++KT + +++ A A D+K A + + + + + I ++KT+
Sbjct: 1745 SEKTNEISNMQKDLEHSNDALKAQ--DLKIQEELRIAHMHLKEQQETIDKLRGIVSEKTD 1802
Query: 537 KYNKCKQLLQDEKAKCNKYADELAKMELKWKEQVKIAENVKLELAEVQDNYKELKRSLEN 596
K + ++ L++ AK + EL E + K + +++E++ K++K
Sbjct: 1803 KLSNMQKDLENSNAKLQEKIQELKANEHQLITLKKDVNETQKKVSEMEQLKKQIKDQSLT 1862
Query: 597 PAERKMEGQN 606
++ ++E N
Sbjct: 1863 LSKLEIENLN 1872
Score = 72.4 bits (176), Expect = 2e-12
Identities = 98/503 (19%), Positives = 212/503 (42%), Gaps = 57/503 (11%)
Query: 148 GLLELKIEKTMKEKEELLKLIAVLEKETAQLREQVGR-------MERELNHEKERCDQLQ 200
G L+ ++ +E +E + + E QL+EQ+ +ERE E+ Q
Sbjct: 862 GALKTELSYKTQELQEKTREVQERLNEMEQLKEQLENRDSTLQTVEREKTLITEKLQQTL 921
Query: 201 AEQKGLT-------EVTQSLKMENEEFKKRFSDATSKAHQLEEDIVSVTHKAIEKETELD 253
E K LT ++ +SL++E ++ K D + +E + + + + ++
Sbjct: 922 EEVKTLTQEKDDLKQLQESLQIERDQLKSDIHDTVNMNIDTQEQLRNALESLKQHQETIN 981
Query: 254 SLKDKLKKAQHEREQLECQLKTEKDEKELYKVHL---KNTEIENTK-LMSEVQTLKNLDG 309
+LK K+ + +E KDE + V + ++ E +NT+ L ++V+ + ++
Sbjct: 982 TLKSKISEEVSRNLHMEENTGETKDEFQQKMVGIDKKQDLEAKNTQTLTADVKDNEIIEQ 1041
Query: 310 NKE--SVITHFKEEIGRLQLCLAEKE----NLQRTFLLTTSSKEDTCFLKEQLRKAEEQV 363
++ S+I E L+ +AEKE +L+ +T ++E+ L ++L+K +E V
Sbjct: 1042 QRKIFSLIQEKNELQQMLESVIAEKEQLKTDLKENIEMTIENQEELRLLGDELKKQQEIV 1101
Query: 364 QATRQEVVFLAKELSDAVNVRDRTMADLHTARLENEKVKKQLADAVAELKLNAMKKDQDK 423
+ + ELS + L + ++ ++QL + E ++ M+K ++
Sbjct: 1102 AQEKNHAIKKEGELSRTCDRLAEVEEKLKEKSQQLQEKQQQLLNVQEE--MSEMQKKINE 1159
Query: 424 TDTLEHELRRE------VEDLKLRLQMAADHYKEKFKECQRLQKQINKLSDQSANNNNVF 477
+ L++EL+ + +E +L L + E+ K + +K + +L +
Sbjct: 1160 IENLKNELKNKELTLEHMETERLELAQKLNENYEEVKSITKERKVLKELQKSFETERDHL 1219
Query: 478 ------TKKTGNQQKVN------------------DASVNTDPATSASTVDVKPSPSAAE 513
+ TG Q K SV+ A +T D++ S + +
Sbjct: 1220 RGYIREIEATGLQTKEELKIAHIHLKEHQETIDELRRSVSEKTAQIINTQDLEKSHTKLQ 1279
Query: 514 ADFDIVTKGQ-VCEMTKEIADKTEKYNKCKQLLQDEKAKCNKYADELAKMELKWKEQVKI 572
+ ++ + Q + KE+++ E N+ + L + K + + L+ E+ +
Sbjct: 1280 EEIPVLHEEQELLPNVKEVSETQETMNELELLTEQSTTKDSTTLARIEMERLRLNEKFQE 1339
Query: 573 AENVKLELAEVQDNYKELKRSLE 595
++ L + +DN K +K +LE
Sbjct: 1340 SQEEIKSLTKERDNLKTIKEALE 1362
Score = 72.4 bits (176), Expect = 2e-12
Identities = 106/508 (20%), Positives = 229/508 (45%), Gaps = 75/508 (14%)
Query: 153 KIEKTMKEKEELLKLIAVLEKETAQLREQV-----GRMERE---------LNHEKERCDQ 198
+++ KEK++L +L VL+ E+ QL+E + +E E L ++E ++
Sbjct: 1436 EMKSVAKEKDDLQRLQEVLQSESDQLKENIKEIVAKHLETEEELKVAHCCLKEQEETINE 1495
Query: 199 LQA----EQKGLTEVTQSLKMENEEFKKRFSDATSKAHQLE-EDIVSVTHKAIE------ 247
L+ ++ ++ + + L+ N++ + + + K Q + I V K E
Sbjct: 1496 LRVNLSEKETEISTIQKQLEAINDKLQNKIQEIYEKEEQFNIKQISEVQEKVNELKQFKE 1555
Query: 248 ----KETELDSLKDKL----KKAQHEREQLECQLKTEKDEKELYK-VHLKNTEI-ENTKL 297
K++ L S++ K+ + Q +E+++ +K +++ K + + + ++ ++ ENTK
Sbjct: 1556 HRKAKDSALQSIESKMLELTNRLQESQEEIQIMIKEKEEMKRVQEALQIERDQLKENTKE 1615
Query: 298 M---------SEVQTLK----NLDGNKESVITHFKE--EIGRLQLCLAEKENLQRTFLLT 342
+ E Q LK N K I H KE E +L L E EN++ T +L
Sbjct: 1616 IVAKMKESQEKEYQFLKMTAVNETQEKMCEIEHLKEQFETQKLNLENIETENIRLTQILH 1675
Query: 343 TSSKEDTCFLKEQ--LRKAEEQVQATRQEVVFLAKELSDAVNVRDRTMADLHTARLENEK 400
+ +E KE+ LR EE ++ R ++ +E + + +H E+++
Sbjct: 1676 ENLEEMRSVTKERDDLRSVEETLKVERDQLKENLRETITRDLEKQEELKIVHMHLKEHQE 1735
Query: 401 VKKQLADAVAEL--KLNAMKKDQDKTDTLEHEL-RREVEDLKLR--LQMAADHYKEKFKE 455
+L V+E +++ M+KD LEH + +DLK++ L++A H KE+ +
Sbjct: 1736 TIDKLRGIVSEKTNEISNMQKD------LEHSNDALKAQDLKIQEELRIAHMHLKEQQET 1789
Query: 456 CQRLQKQINKLSDQSAN-NNNVFTKKTGNQQKVNDASVNTDPATSASTVDVKPSPSAAEA 514
+L+ +++ +D+ +N ++ Q+K+ + N + + +E
Sbjct: 1790 IDKLRGIVSEKTDKLSNMQKDLENSNAKLQEKIQELKANEHQLITLKKDVNETQKKVSEM 1849
Query: 515 DFDIVTKGQVCEMTKEIADKTEKYNKCKQLLQDEKAKCNKYADELAKMELKWKEQVKIAE 574
+ ++ K+I D++ +K + + K ++ +E+ + + ++ E
Sbjct: 1850 E----------QLKKQIKDQSLTLSKLEIENLNLAQKLHENLEEMKSVMKERDNLRRVEE 1899
Query: 575 NVKLELAEVQDNYKELK-RSLENPAERK 601
+KLE +++++ +E K R LE E K
Sbjct: 1900 TLKLERDQLKESLQETKARDLEIQQELK 1927
Score = 70.9 bits (172), Expect = 4e-12
Identities = 96/469 (20%), Positives = 208/469 (44%), Gaps = 41/469 (8%)
Query: 138 SDMLVVTTKAGLLELKIEKTMKEKEELLKLIAVLEKETAQLREQVGRMERELNHEKERCD 197
S ML +T + + +I+ +KEKEE+ ++ L+ E QL+E + ++ +E+
Sbjct: 1569 SKMLELTNRLQESQEEIQIMIKEKEEMKRVQEALQIERDQLKENTKEIVAKMKESQEK-- 1626
Query: 198 QLQAEQKGLTEVTQSLKMENEEFKKRFSDATSKAHQLEEDIVSVTHKAIEKETELDSLKD 257
+ Q + TQ E E K++F +E + + +T E E+ S+
Sbjct: 1627 EYQFLKMTAVNETQEKMCEIEHLKEQFETQKLNLENIETENIRLTQILHENLEEMRSV-- 1684
Query: 258 KLKKAQHEREQLECQLKTEKDEKELYKVHLKNTEIENTKLMSEVQTLKNLDGNKESVITH 317
ER+ L +T K E++ K +L+ T + + E++ + +
Sbjct: 1685 -----TKERDDLRSVEETLKVERDQLKENLRETITRDLEKQEELKIV-------HMHLKE 1732
Query: 318 FKEEIGRLQLCLAEK----ENLQRTFLLTTSS-KEDTCFLKEQLRKAEEQVQATRQEVVF 372
+E I +L+ ++EK N+Q+ + + K ++E+LR A ++ ++ +
Sbjct: 1733 HQETIDKLRGIVSEKTNEISNMQKDLEHSNDALKAQDLKIQEELRIAHMHLKEQQETIDK 1792
Query: 373 LAKELSDAVNVRDRTMADLHTARLENEKVKKQLADAVA-ELKLNAMKKD----QDKTDTL 427
L +S+ + DL + N K+++++ + A E +L +KKD Q K +
Sbjct: 1793 LRGIVSEKTDKLSNMQKDLENS---NAKLQEKIQELKANEHQLITLKKDVNETQKKVSEM 1849
Query: 428 EHELRREVEDLKLRLQMAADHYKEKFKECQRLQKQINKLSDQSANNNNVFTKKTGNQQKV 487
E +L+++++D L L E Q+L + + ++ +N+ ++ K+
Sbjct: 1850 E-QLKKQIKDQSLTLSKLE---IENLNLAQKLHENLEEMKSVMKERDNL--RRVEETLKL 1903
Query: 488 -NDASVNTDPATSASTVDVKPSPSAAEADFDIVTKGQVCEMTKEIADKTEKYNKCKQLLQ 546
D + T A ++++ A K V ++ ++I++KT + + ++ L
Sbjct: 1904 ERDQLKESLQETKARDLEIQQELKTARM-LSKEHKETVDKLREKISEKTIQISDIQKDLD 1962
Query: 547 DEKAKCNKYADELAKMELKWKEQVKIAENVKLELAEVQDNYKELKRSLE 595
K + K EL K EL + +++ E+V + ++ + ++LK+ E
Sbjct: 1963 KSKDELQKKIQELQKKEL---QLLRVKEDVNMSHKKINE-MEQLKKQFE 2007
Score = 70.5 bits (171), Expect = 6e-12
Identities = 95/493 (19%), Positives = 205/493 (41%), Gaps = 57/493 (11%)
Query: 153 KIEKTMKEKEELLKLIAVLEKETAQLREQVGRMERELNHEKERCDQLQAEQKGLTEVTQS 212
+I+ KE++ L + LE + QL+E + ++ + + +Q K T
Sbjct: 1343 EIKSLTKERDNLKTIKEALEVKHDQLKEHIRETLAKIQESQSKQEQ-SLNMKEKDNETTK 1401
Query: 213 LKMENEEFKKRFS-------DATSKAHQLEEDIVSVTHKAIEK----------ETELDSL 255
+ E E+FK + S + + +L+E + A EK ++E D L
Sbjct: 1402 IVSEMEQFKPKDSALLRIEIEMLGLSKRLQESHDEMKSVAKEKDDLQRLQEVLQSESDQL 1461
Query: 256 KDKLK-------KAQHEREQLECQLKTEKDEKELYKVHLKNTEIENTKLMSEVQTLKNLD 308
K+ +K + + E + C LK +++ +V+L E E + + +++ + +
Sbjct: 1462 KENIKEIVAKHLETEEELKVAHCCLKEQEETINELRVNLSEKETEISTIQKQLEAINDKL 1521
Query: 309 GNKESVITHFKEEIGRLQLC-LAEKENLQRTFLLTTSSKEDTC-FLKEQLRKAEEQVQAT 366
NK I +E+ Q+ + EK N + F +K+ ++ ++ + ++Q +
Sbjct: 1522 QNKIQEIYEKEEQFNIKQISEVQEKVNELKQFKEHRKAKDSALQSIESKMLELTNRLQES 1581
Query: 367 RQEVVFLAKELSDAVNVRDRTMADLHTARLENEKVKKQLADAVAE-----------LKLN 415
++E+ + KE + V++ ++E +++K+ + VA+ LK+
Sbjct: 1582 QEEIQIMIKEKEEMKRVQE-------ALQIERDQLKENTKEIVAKMKESQEKEYQFLKMT 1634
Query: 416 AMKKDQDKTDTLEHELRREVEDLKLRLQMAADHYKEKFKECQRLQKQINKLSDQSANNNN 475
A+ + Q+K +EH L+ + E KL L+ + E + Q L + + ++ + ++
Sbjct: 1635 AVNETQEKMCEIEH-LKEQFETQKLNLE---NIETENIRLTQILHENLEEMRSVTKERDD 1690
Query: 476 VFT-----KKTGNQQKVNDASVNTDPATSASTVDVKPSPSAAEADFDIVTKGQVCEMTKE 530
+ + K +Q K N T + + + +G V E T E
Sbjct: 1691 LRSVEETLKVERDQLKENLRETITRDLEKQEELKIVHMHLKEHQETIDKLRGIVSEKTNE 1750
Query: 531 IADKTEKYNKCKQLLQDEKAKCNKYADELAKMELKWKEQVKIAENVKLELAEVQDNYKEL 590
I++ + L KA+ K +EL + KEQ + + ++ ++E D +
Sbjct: 1751 ISNMQKDLEHSNDAL---KAQDLKIQEELRIAHMHLKEQQETIDKLRGIVSEKTDKLSNM 1807
Query: 591 KRSLENPAERKME 603
++ LEN + E
Sbjct: 1808 QKDLENSNAKLQE 1820
Score = 67.8 bits (164), Expect = 4e-11
Identities = 109/511 (21%), Positives = 205/511 (40%), Gaps = 97/511 (18%)
Query: 142 VVTTKAGLLELKIEKTMK--EKEELLKLIAVLEKETAQLREQVGRMERELNHEKERCDQL 199
++ K L E+ +E + EK++L +L+ + E++ + R L Q
Sbjct: 352 IMDLKKQLEEVSLETRAQAMEKDQLAQLLEEKDLLQKVQNEKIENLTRMLVTSSSLTLQQ 411
Query: 200 QAEQKGLTEVTQSL----KMENEEFKKRFS---DATSKAHQL--------------EEDI 238
+ + K VT L KM+N + +F+ + T+K H+L E D+
Sbjct: 412 ELKAKRKRRVTWCLGKINKMKNSNYADQFNIPTNITTKTHKLSINLLREIDESVCSESDV 471
Query: 239 VSVTHKAIEK---------------ETELDSLK---DKL----KKAQHEREQLECQLKTE 276
S T + + E+EL+SL+ D L ++ + E+E++E +LK +
Sbjct: 472 FSNTLDTLSEIEWNPATKLLNQENIESELNSLRADYDNLVLDYEQLRTEKEEMELKLKEK 531
Query: 277 KDEKELYKVHLKNTEIENTKLMSEVQTLKNLDGNKESVITHFKEEIGRLQLCLAEKENLQ 336
D E + K + + +L+ E+ LKNL + E + E+ L EKE
Sbjct: 532 NDLDEFEALERKTKKDQEMQLIHEISNLKNLVKHAEVYNQDLENELSSKVELLREKE--- 588
Query: 337 RTFLLTTSSKEDTCFLKEQLRKAEEQVQATRQEVV-----FLAKELSDAVNVRDRTMADL 391
+Q++K +E + + + E + + + + D ++ +T+ D
Sbjct: 589 -----------------DQIKKLQEYIDSQKLENIKMDLSYSLESIEDPKQMK-QTLFDA 630
Query: 392 HTARLENEKVKKQLADAVAELKLNAMKKDQDKTDTLEHELRREVEDLKLRLQMAADHYKE 451
T L+ ++ L ELK MK+ +E++++ L+ + +M D KE
Sbjct: 631 ETVALDAKRESAFLRSENLELK-EKMKELATTYKQMENDIQLYQSQLEAKKKMQVDLEKE 689
Query: 452 ---KFKECQRLQKQINKLSDQSANNNNVFTKKTGNQQKVNDASVNTDPATSASTV---DV 505
F E +L I+ + N K + QK + V + A + ++
Sbjct: 690 LQSAFNEITKLTSLIDGKVPKDLLCNLELEGKITDLQKELNKEVEENEALREEVILLSEL 749
Query: 506 KPSPSAAEADFDIVTKGQVCEMTKEIADKTEKYNKCKQLLQDEKAKCNKYADELAKMELK 565
K PS E + KEI DK+E+ + ++ EK +K E+ E +
Sbjct: 750 KSLPSEVE------------RLRKEIQDKSEELH----IITSEK---DKLFSEVVHKESR 790
Query: 566 WKEQVKIAENVKLELAEVQDNYKELKRSLEN 596
+ ++ K +LA Q NYK + +N
Sbjct: 791 VQGLLEEIGKTKDDLATTQSNYKSTDQEFQN 821
Score = 62.0 bits (149), Expect = 2e-09
Identities = 94/484 (19%), Positives = 191/484 (39%), Gaps = 96/484 (19%)
Query: 155 EKTMKEKEELLKLIAVLEKETAQLREQVGRMERELNHEKERCDQLQAEQKGLTEVTQSLK 214
+K + E E+L K I ++L + + ++L+ E + E+ L V ++LK
Sbjct: 1843 QKKVSEMEQLKKQIKDQSLTLSKLEIENLNLAQKLHENLEEMKSVMKERDNLRRVEETLK 1902
Query: 215 MENEEFKKRFSDATSKAHQLEEDI-----VSVTHK-AIEK---------------ETELD 253
+E ++ K+ + ++ ++++++ +S HK ++K + +LD
Sbjct: 1903 LERDQLKESLQETKARDLEIQQELKTARMLSKEHKETVDKLREKISEKTIQISDIQKDLD 1962
Query: 254 SLKDKLKKAQHEREQLECQLKTEKDEKELYKVHLKNTEIENTKLMSEVQTL--KNLDGNK 311
KD+L+K E ++ E QL K++ + H K E+E K E Q L +++ +
Sbjct: 1963 KSKDELQKKIQELQKKELQLLRVKEDVNM--SHKKINEMEQLKKQFEAQNLSMQSVRMDN 2020
Query: 312 ESVITHFKEEIGRLQLCLAEKENLQRTFLLTTSSKEDTCFLKEQLRKAEEQVQATRQEVV 371
+ E + +++ E++ L+R +KE L+ +Q AT +E++
Sbjct: 2021 FQLTKKLHESLEEIRIVAKERDELRR--------------IKESLKMERDQFIATLREMI 2066
Query: 372 FLAKELSDAVNVRDRTMADLHTARLENEKVK----KQLADAVAELK-----LNAMKKDQD 422
++ + V R ++D E+ + K K+L +E+ LN + D +
Sbjct: 2067 ARDRQ-NHQVKPEKRLLSDGQQHLTESLREKCSRIKELLKRYSEMDDHYECLNRLSLDLE 2125
Query: 423 KTDTLEHELRREVEDLKLRLQMAADHYKEKFKECQRLQKQINKLSDQSANNNNVFTKKTG 482
K + EL V+ + H ++ F QR + +++ + + TK
Sbjct: 2126 KEIEFQKELSMRVKANLSLPYLQTKHIEKLFTANQRCSMEFHRIMKKLKYVLSYVTKIKE 2185
Query: 483 NQQKVNDASVNTDPATSASTVDVKPSPSAAEADFDIVTKGQVCEMTKEIADKTEKYNKCK 542
Q + S + E DF D+ EK +
Sbjct: 2186 EQHE---------------------SINKFEMDF---------------IDEVEKQKELL 2209
Query: 543 QLLQDEKAKCNKYADELAKMELKWKEQVKIAE-----------NVKLELAEVQDNYKELK 591
+Q + C+ + EL ++L + I E ++K E +V N KE+
Sbjct: 2210 IKIQHLQQDCDVPSRELRDLKLNQNMDLHIEEILKDFSESEFPSIKTEFQQVLSNRKEMT 2269
Query: 592 RSLE 595
+ LE
Sbjct: 2270 QFLE 2273
Score = 57.4 bits (137), Expect = 5e-08
Identities = 111/537 (20%), Positives = 200/537 (37%), Gaps = 76/537 (14%)
Query: 114 ASTPFQFRASSPVEELLTMEDEGNSDMLVVTTKAGLLELKIEKTMKEKEELLKLIAVLEK 173
A+ + + +E+L T + + + K L+ + K KEE + I E
Sbjct: 2140 ANLSLPYLQTKHIEKLFTANQRCSMEFHRIMKK---LKYVLSYVTKIKEEQHESINKFEM 2196
Query: 174 ETAQLREQVGRMERELNHEKERCDQLQAEQKGLTEVTQSLKMENEEFKKRFSDATSKAHQ 233
+ E+ + ++ H ++ CD E + L ++ Q++ + EE K FS++ + +
Sbjct: 2197 DFIDEVEKQKELLIKIQHLQQDCDVPSRELRDL-KLNQNMDLHIEEILKDFSESEFPSIK 2255
Query: 234 LEEDIVSVTHKAIEKETE--LDSLKD--KLKKAQHEREQLECQLK--------------T 275
E V K + + E L++ D KLK + CQ+ T
Sbjct: 2256 TEFQQVLSNRKEMTQFLEEWLNTRFDIEKLKNGIQKENDRICQVNNFFNNRIIAIMNEST 2315
Query: 276 EKDEKEL-----YKVHLKNTEIENTKLMSEVQTLKNLDGNKESVITHFKEEIGRLQLCLA 330
E +E+ ++ LK+ + +N KL QTLK + V
Sbjct: 2316 EFEERSATISKEWEQDLKSLKEKNEKLFKNYQTLKTSLASGAQV-----------NPTTQ 2364
Query: 331 EKENLQRTFLLTTSSKEDTCFLKEQLRKAEEQVQATRQEVVFLAKELSDAVNVRDRTMAD 390
+ +N T T + E L+ L +A+E +++ + KEL ++ + A
Sbjct: 2365 DNKNPHVTSRATQLTTEKIRELENSLHEAKESAMHKESKIIKMQKELEVTNDIIAKLQAK 2424
Query: 391 LHTARLENEKVKKQLADAVAELKLNAMKKDQDKTDTLEHELRREVEDLKLRLQMAADHYK 450
+H + EK K+ + QDK + E+EDLK++L
Sbjct: 2425 VHESNKCLEKTKETIQVL------------QDKVALGAKPYKEEIEDLKMKLVKID---L 2469
Query: 451 EKFKECQRLQKQINKLSDQSANNNNVFTKKTGN---QQKVNDASV---NTDPATSASTVD 504
EK K + +K+I+ V N Q+ D SV +TDP S +
Sbjct: 2470 EKMKNAKEFEKEISATKATVEYQKEVIRLLRENLRRSQQAQDTSVISEHTDPQPSNKPLT 2529
Query: 505 VKPSPSAAEADFDIVTKGQVCEMTKEIADKTEKYNKCKQLLQDEKAKCNKYADELAKMEL 564
+ ++ K + + KEI+ K ++ N+ ++E N++ K
Sbjct: 2530 CGGGSGIVQNTKALILKSEHIRLEKEIS-KLKQQNEQLIKQKNELLSNNQHLSNEVK--- 2585
Query: 565 KWKEQVKIAENVKLELAEVQDNYKELKRSLENPAERKMEGQNSQSPQCFKT-CSEQN 620
WKE+ E K E +P K+ G S+ Q + C E+N
Sbjct: 2586 TWKERTLKREAHKQVTCE------------NSPKSPKVTGTASKKKQITPSQCKERN 2630
Score = 36.2 bits (82), Expect = 0.12
Identities = 56/236 (23%), Positives = 104/236 (44%), Gaps = 32/236 (13%)
Query: 381 VNVRDRTMADLHTARLENEKVKKQLADAVAELKLNAMKKDQ-----DKTDTLEHELRREV 435
VN A L R E +KKQL + E + AM+KDQ ++ D L+ ++
Sbjct: 335 VNEVSTDEALLKRYRKEIMDLKKQLEEVSLETRAQAMEKDQLAQLLEEKDLLQKVQNEKI 394
Query: 436 EDLKLRLQMAADHYKEKFKECQRLQK------QINKLSDQS-ANNNNVFTKKTGNQQKVN 488
E+L L ++ ++ + +R ++ +INK+ + + A+ N+ T T K++
Sbjct: 395 ENLTRMLVTSSSLTLQQELKAKRKRRVTWCLGKINKMKNSNYADQFNIPTNITTKTHKLS 454
Query: 489 -------DASVNTDPATSASTVDVKPSPSAAEADFDIVTKGQVCE-MTKEIADKTEKYNK 540
D SV ++ ++T+D + +E +++ TK E + E+ Y+
Sbjct: 455 INLLREIDESVCSESDVFSNTLD-----TLSEIEWNPATKLLNQENIESELNSLRADYDN 509
Query: 541 CKQLLQDEKAKCNKYADELAKMELKWKEQVKIAENVKLELAEVQDNYKELKRSLEN 596
+L E+ + K +MELK KE+ + E LE +D +L + N
Sbjct: 510 L--VLDYEQLRTEK-----EEMELKLKEKNDLDEFEALERKTKKDQEMQLIHEISN 558
>gi|148596984 golgi autoantigen, golgin subfamily b, macrogolgin (with
transmembrane signal), 1 [Homo sapiens]
Length = 3259
Score = 86.3 bits (212), Expect = 1e-16
Identities = 96/496 (19%), Positives = 222/496 (44%), Gaps = 65/496 (13%)
Query: 150 LELKIEKTMKEKEELLKLIAVLEKETAQLREQVGRMERELNHEKERCDQLQAEQKG---- 205
LE EK +KEK+ + + + L +E L E +G ++ LN + + QLQ
Sbjct: 2127 LEQAEEKHLKEKKNMQEKLDALRREKVHLEETIGEIQVTLNKKDKEVQQLQENLDSTVTQ 2186
Query: 206 LTEVTQSLKM----------ENEEFKKRFSDATSKAHQ---LEEDIVSVTHKAIEKET-E 251
L T+S+ E ++++++FSDA + L+ED SV + + +
Sbjct: 2187 LAAFTKSMSSLQDDRDRVIDEAKKWERKFSDAIQSKEEEIRLKEDNCSVLKDQLRQMSIH 2246
Query: 252 LDSLKDKLKKAQHEREQLECQLKTEKDEKELYKVHLKNTEIENTKLMSEVQTLKNLDGNK 311
++ LK + + +H+++ E + +TE +L + + EN +L+S+++ ++L +
Sbjct: 2247 MEELKINISRLEHDKQIWESKAQTEV---QLQQKVCDTLQGENKELLSQLEETRHLYHSS 2303
Query: 312 ESVITHFKEEI-----------GRLQLCLAEKENLQRTFLLTTSSKEDTCFLKEQLRKAE 360
++ + + E+ L+ C +K NL+ + +++ F EQL E
Sbjct: 2304 QNELAKLESELKSLKDQLTDLSNSLEKCKEQKGNLEGIIRQQEADIQNSKFSYEQL---E 2360
Query: 361 EQVQATRQEVVFLAKELSDAVNVRDRTMADLHTARLENEKV-----KKQLADAVAELKLN 415
+QA+R+ L L + +N++++ + L + + E +V ++Q + EL+ N
Sbjct: 2361 TDLQASRE----LTSRLHEEINMKEQKIISLLSGKEEAIQVAIAELRQQHDKEIKELE-N 2415
Query: 416 AMKKDQDKTDTLEHELRREVEDLKLRLQMAADHYKEKFKECQRLQKQINKLSDQSANNNN 475
+ +++++ LE E ++ V+ ++ KE ++ +L + +S + +
Sbjct: 2416 LLSQEEEENIVLEEENKKAVDKTNQLMETLKTIKKENIQQKAQLDSFVKSMSSLQNDRDR 2475
Query: 476 VFTKKTGNQQKVNDASVNTD-------PATSASTVDVKPSPSAAEADFDIVTKGQVCEMT 528
+ G+ Q++ + ++ +A +K + D + + ++
Sbjct: 2476 I----VGDYQQLEERHLSIILEKDQLIQEAAAENNKLKEEIRGLRSHMDDLNS-ENAKLD 2530
Query: 529 KEIADKTEKYNKC--------KQLLQDEKAKCNKYADELAKMELKWKEQVKIAENVKLEL 580
E+ E N+ KQLL+ + + + ++ AK+E K KE + E+++
Sbjct: 2531 AELIQYREDLNQVITIKDSQQKQLLEVQLQQNKELENKYAKLEEKLKESEEANEDLRRSF 2590
Query: 581 AEVQDNYKELKRSLEN 596
+Q+ ++L + +E+
Sbjct: 2591 NALQEEKQDLSKEIES 2606
Score = 77.8 bits (190), Expect = 4e-14
Identities = 110/568 (19%), Positives = 246/568 (43%), Gaps = 79/568 (13%)
Query: 126 VEELLTMEDEGNSDMLVVTTKAGLLELKIEKTMKEKEELLKLIAV-LEKETAQLREQVGR 184
+++L++ ++E S + ++ KI+ + E+E+L+K + LE + + E++ +
Sbjct: 1397 LQKLISKKEEDVSYLSGQLSEKEAALTKIQTEIIEQEDLIKALHTQLEMQAKEHDERIKQ 1456
Query: 185 MERELNHEKERCDQLQAEQKGLTEVTQSLKM----------ENEEFKKRFSDATSKAHQL 234
++ EL K++ +++ E + ++ + L+ EN+ ++ S A +L
Sbjct: 1457 LQVELCEMKQKPEEIGEESRAKQQIQRKLQAALISRKEALKENKSLQEELSLARGTIERL 1516
Query: 235 EEDIVSVTHKAIEKETELDSLKDKLKKAQHEREQLECQLKTEKDEK-------ELYKVHL 287
+ + V + + E D++ +L Q ER++L ++ E E K+ L
Sbjct: 1517 TKSLADVESQVSAQNKEKDTVLGRLALLQEERDKLITEMDRSLLENQSLSSSCESLKLAL 1576
Query: 288 KNTEIENTKLMSEVQTLKN---------------LDGNKESVITHFK---EEIGRLQLCL 329
+ + KL+ E+++LK+ L E ++ ++ E R+Q +
Sbjct: 1577 EGLTEDKEKLVKEIESLKSSKIAESTEWQEKHKELQKEYEILLQSYENVSNEAERIQHVV 1636
Query: 330 ----AEKENLQRTFLLTTSSKEDTCFLKEQLRKAEEQVQATRQEVVFLAK----ELSDAV 381
EK+ L T ++K++T ++QL++AE++++ ++++ AK ++ +
Sbjct: 1637 EAVRQEKQELYGKLRSTEANKKET---EKQLQEAEQEMEEMKEKMRKFAKSKQQKILELE 1693
Query: 382 NVRDRTMADLHTARLENEKVKKQLADAVAELK--LNAMKKDQD----KTDTLEHE---LR 432
DR A++H A ++ + L + A +K L +K + + K +L E L
Sbjct: 1694 EENDRLRAEVHPAGDTAKECMETLLSSNASMKEELERVKMEYETLSKKFQSLMSEKDSLS 1753
Query: 433 REVEDLKLRLQMAADHYKEKFKECQRLQKQIN-KLSDQSANNNNVFTKKT----GNQQKV 487
EV+DLK +++ + KQ N + +++ N NV + T G ++
Sbjct: 1754 EEVQDLKHQIE-------------GNVSKQANLEATEKHDNQTNVTEEGTQSIPGETEEQ 1800
Query: 488 NDASVNTDPATSASTVDVKPSPSAAEADFDIVTK-----GQVCEMTKEIADKTEKYNKCK 542
+ S++T P S S K + A DF + Q+ ++ + IA E+ K K
Sbjct: 1801 DSLSMSTRPTCSESVPSAKSANPAVSKDFSSHDEINNYLQQIDQLKERIAGLEEEKQKNK 1860
Query: 543 QLLQDEKAKCNKYADELAKMELKWKEQVKIAENVKLELAEVQDNYKELKRSLENPAERKM 602
+ Q + + N +++ + + K + + L ++Q+ + + E E K
Sbjct: 1861 EFSQTLENEKNTLLSQISTKDGELKMLQEEVTKMNLLNQQIQEELSRVTKLKETAEEEKD 1920
Query: 603 EGQNSQSPQCFKTCSEQNGYVLTLSNAQ 630
+ + Q + Y +++AQ
Sbjct: 1921 DLEERLMNQLAELNGSIGNYCQDVTDAQ 1948
Score = 75.5 bits (184), Expect = 2e-13
Identities = 108/499 (21%), Positives = 206/499 (41%), Gaps = 68/499 (13%)
Query: 153 KIEKTMKEKEELLKLIAVLEKETAQLREQVGRMERELNHEKERCDQLQAEQKGLTEVTQS 212
+I +++ ++L + IA LE+E + +E +E E N + E K L E
Sbjct: 1834 EINNYLQQIDQLKERIAGLEEEKQKNKEFSQTLENEKNTLLSQISTKDGELKMLQEEVTK 1893
Query: 213 LKMENEEFKKRFSDATSKAHQLEEDIVSVTHKAIEKETELD----SLKDKLKKAQHEREQ 268
+ + N++ ++ S T EE+ + + + + EL+ + + AQ + E
Sbjct: 1894 MNLLNQQIQEELSRVTKLKETAEEEKDDLEERLMNQLAELNGSIGNYCQDVTDAQIKNEL 1953
Query: 269 LECQLKTEKD-----EKELYKVHLKNTEIENT---KLMSEVQTLKNLDGNK------ESV 314
LE ++K K E+E ++ + T++E+ + + ++Q + GNK + +
Sbjct: 1954 LESEMKNLKKCVSELEEEKQQLVKEKTKVESEIRKEYLEKIQGAQKEPGNKSHAKELQEL 2013
Query: 315 ITHFKEEIGRLQL-CLAEKEN---LQRTF----LLTTSSKEDTCFLKEQLRKAEEQVQAT 366
+ ++E+ +LQ C+ +E L+RT + T S++D KE L +A E +
Sbjct: 2014 LKEKQQEVKQLQKDCIRYQEKISALERTVKALEFVQTESQKDLEITKENLAQAVEHRKKA 2073
Query: 367 RQEVVFLAKELSDAVNVRDRTMADLHTARLENEKVKKQLADAVAELKLNAMKKDQDKTDT 426
+ E+ L D + R +AD N K+KK+L +K +KD+D
Sbjct: 2074 QAELASFKVLLDDTQSEAARVLAD-------NLKLKKELQSNKESVKSQMKQKDEDLERR 2126
Query: 427 LEH-----------------ELRREVEDLKLRLQMAADHYKEKFKECQRLQKQINKLSDQ 469
LE LRRE L+ + +K KE Q+LQ+ ++ Q
Sbjct: 2127 LEQAEEKHLKEKKNMQEKLDALRREKVHLEETIGEIQVTLNKKDKEVQQLQENLDSTVTQ 2186
Query: 470 SANNNNVFTKKTGNQQKVNDASVNTDPATS---ASTVDVKPSPSAAEADFDIVTKGQVCE 526
A FTK + Q D ++ + + K + D V K Q+ +
Sbjct: 2187 LA----AFTKSMSSLQDDRDRVIDEAKKWERKFSDAIQSKEEEIRLKEDNCSVLKDQLRQ 2242
Query: 527 MTKEIA-----------DKTEKYNKCKQLLQDEKAKCNKYADELAKMELKWKEQVKIAEN 575
M+ + DK +K + +Q ++ C+ E ++ + +E + +
Sbjct: 2243 MSIHMEELKINISRLEHDKQIWESKAQTEVQLQQKVCDTLQGENKELLSQLEETRHLYHS 2302
Query: 576 VKLELAEVQDNYKELKRSL 594
+ ELA+++ K LK L
Sbjct: 2303 SQNELAKLESELKSLKDQL 2321
Score = 71.6 bits (174), Expect = 3e-12
Identities = 114/535 (21%), Positives = 220/535 (41%), Gaps = 59/535 (11%)
Query: 150 LELKIEKTMKEKEELLKLIAVLEKETAQLREQVGRMERELNHEKERCDQLQAEQKGLTEV 209
+E ++ KEK+ +L +A+L++E +L ++ R E C+ L+ +GLTE
Sbjct: 1523 VESQVSAQNKEKDTVLGRLALLQEERDKLITEMDRSLLENQSLSSSCESLKLALEGLTED 1582
Query: 210 TQSLKMENEEFK-KRFSDATS-----KAHQLEEDIVSVTHKAIEKET------------E 251
+ L E E K + +++T K Q E +I+ +++ + E E
Sbjct: 1583 KEKLVKEIESLKSSKIAESTEWQEKHKELQKEYEILLQSYENVSNEAERIQHVVEAVRQE 1642
Query: 252 LDSLKDKLKKAQHEREQLECQLKTEKDEKELYKVHLK-----------NTEIENTKLMSE 300
L KL+ + +++ E QL+ + E E K ++ E EN +L +E
Sbjct: 1643 KQELYGKLRSTEANKKETEKQLQEAEQEMEEMKEKMRKFAKSKQQKILELEEENDRLRAE 1702
Query: 301 V----QTLKNLDGNKESVITHFKEEIGRLQLCLAEKENLQRTFLLTTSSKEDTCFLKEQL 356
V T K S KEE+ R+++ E E L + F S K+ L E++
Sbjct: 1703 VHPAGDTAKECMETLLSSNASMKEELERVKM---EYETLSKKFQSLMSEKDS---LSEEV 1756
Query: 357 RKAEEQVQ--ATRQEVVFLAKELSDAVNVRDRTMADLHTARLENEKV----KKQLADAVA 410
+ + Q++ ++Q + ++ + NV + + E + + + +++V
Sbjct: 1757 QDLKHQIEGNVSKQANLEATEKHDNQTNVTEEGTQSIPGETEEQDSLSMSTRPTCSESVP 1816
Query: 411 ELKL--NAMKKDQDKTDTLEHELRREVEDLKLRLQMAADHYKEKFKE-CQRLQKQINKLS 467
K A+ KD D + + L ++++ LK R+ + K+K KE Q L+ + N L
Sbjct: 1817 SAKSANPAVSKDFSSHDEINNYL-QQIDQLKERI-AGLEEEKQKNKEFSQTLENEKNTLL 1874
Query: 468 DQSANNNNVFTKKTGNQQKVNDASVNTDPATSASTVDVKPSPSAAEADFDIVTKGQVCEM 527
Q + + K+N + S T +K + + D + Q+ E+
Sbjct: 1875 SQISTKDGELKMLQEEVTKMNLLNQQIQEELSRVT-KLKETAEEEKDDLEERLMNQLAEL 1933
Query: 528 TKEIA----DKTEKYNKCKQLLQDEKAKCNKYADELAKMELKW-KEQVKIAENVKLE-LA 581
I D T+ K +LL+ E K EL + + + KE+ K+ ++ E L
Sbjct: 1934 NGSIGNYCQDVTDAQIK-NELLESEMKNLKKCVSELEEEKQQLVKEKTKVESEIRKEYLE 1992
Query: 582 EVQDNYKEL-KRSLENPAERKMEGQNSQSPQCFKTCSEQNGYVLTLSNAQPVLQY 635
++Q KE +S + ++ + + Q K C + L L++
Sbjct: 1993 KIQGAQKEPGNKSHAKELQELLKEKQQEVKQLQKDCIRYQEKISALERTVKALEF 2047
Score = 62.0 bits (149), Expect = 2e-09
Identities = 116/524 (22%), Positives = 217/524 (41%), Gaps = 77/524 (14%)
Query: 133 EDEGNSDML--VVTTKAGLLELKIEKTMKEKE-ELLKLIAVLEKETA---QLREQVGRME 186
ED+ N + VT+K +E+ +++T+ EKE EL + LE++ A Q + V +M
Sbjct: 1039 EDKENKEYSEKCVTSKCQEIEIYLKQTISEKEVELQHIRKDLEEKLAAEEQFQALVKQMN 1098
Query: 187 RELNHEKERCDQLQAEQKGLTEVTQSLKMENEEFKKRFSDATSKAH-------------- 232
+ L + + D LQAE + Q L N + S A K
Sbjct: 1099 QTLQDKTNQIDLLQAEISENQAIIQKLITSNTDASDGDSVALVKETVVISPPCTGSSEHW 1158
Query: 233 --QLEEDIVSVTHKAIEKETE---------LDSLKDKLKKAQHEREQLECQLKTEKDEKE 281
+LEE I+ A+EKE E L S K LKKAQ + L +LK +KD+
Sbjct: 1159 KPELEEKIL-----ALEKEKEQLQKKLQEALTSRKAILKKAQEKERHLREELKQQKDDYN 1213
Query: 282 LYKVHLKNTEIENTKL-----MSEVQTLKNLDGNKESVITHFKEEIGRL-----QLCLAE 331
+ EN + ++Q +++DG S T +E L A
Sbjct: 1214 RLQEQFDEQSKENENIGDQLRQLQIQVRESIDGKLPS--TDQQESCSSTPGLEEPLFKAT 1271
Query: 332 KENLQRTFLLTT------SSKEDTCFLKEQLRKAEEQVQATRQEVVFLAKELSDAVNVRD 385
+++ + L + S ED L+ A+ + Q E + EL + +
Sbjct: 1272 EQHHTQPVLESNLCPDWPSHSEDASALQGGTSVAQIKAQLKEIEAEKVELELKVSSTTSE 1331
Query: 386 RTMADLHTARLENEKVKKQLADAVAELKLNAMKKDQDKTDTLEHELRREVEDLKLRLQMA 445
T +L+ E++ KQ L++ ++K + + L++++E +L++
Sbjct: 1332 LTKKSEEVFQLQ-EQINKQ------GLEIESLKTVSHEAEVHAESLQQKLESSQLQI-AG 1383
Query: 446 ADHYKEKFKECQRLQKQINKLSDQSANNNNVFTKKTGNQQKVNDASVNTDPATSASTVDV 505
+H +E + LQK I+K + + + ++K K+ + + A +
Sbjct: 1384 LEHLRELQPKLDELQKLISKKEEDVSYLSGQLSEKEAALTKIQTEIIEQEDLIKA--LHT 1441
Query: 506 KPSPSAAEADFDI-VTKGQVCEMTKEIADKTEKYNKCKQLLQDEKAKCNKYADELAKMEL 564
+ A E D I + ++CEM K+ ++ + ++ KQ +Q +L +
Sbjct: 1442 QLEMQAKEHDERIKQLQVELCEM-KQKPEEIGEESRAKQQIQ----------RKLQAALI 1490
Query: 565 KWKEQVKIAENVKLELAEVQDNYKELKRSLENPAERKMEGQNSQ 608
KE +K ++++ EL+ + + L +SL + E ++ QN +
Sbjct: 1491 SRKEALKENKSLQEELSLARGTIERLTKSLAD-VESQVSAQNKE 1533
Score = 60.8 bits (146), Expect = 5e-09
Identities = 98/494 (19%), Positives = 208/494 (42%), Gaps = 79/494 (15%)
Query: 114 ASTPFQFRASSPVE------ELLTMEDEGNSDMLVVTT------------KAGLLELKI- 154
AST Q R S + EL + + +G+ + V K+ +LEL++
Sbjct: 640 ASTEHQSRTSEEISLNDAGVELKSTKQDGDKSLSAVPDIGQCHQDELERLKSQILELELN 699
Query: 155 -----EKTMKEKEELLKLIAVLEKETAQLREQVGRMERELNHEKERCDQLQAEQKGLTEV 209
E K +E K I+ L + + ++ E DQL ++ K L+ V
Sbjct: 700 FHKAQEIYEKNLDEKAKEISNLNQLIEEFKKNADNNSSAFTALSEERDQLLSQVKELSMV 759
Query: 210 TQ--------SLKMENEEFKKRFSDATSKAHQ--LEEDIVSVTHKAIEKETELDSLKDKL 259
T+ + + E ++R + AH L E I S++ +A K+ +++ L+++L
Sbjct: 760 TELRAQVKQLEMNLAEAERQRRLDYESQTAHDNLLTEQIHSLSIEAKSKDVKIEVLQNEL 819
Query: 260 KKAQHEREQLECQLKTEKDEKELYKVHLKNTEIENTKLMSEVQTLKNLDGNKESVITHFK 319
Q + + +++ + + L+N E SEV L+G + + H
Sbjct: 820 DDVQLQFSEQSTLIRSLQSQ-------LQNKE-------SEV-----LEGAER--VRHIS 858
Query: 320 EEIGRLQLCLAEKE-NLQRTFLLTTSSKEDTCFLKEQLRKAEEQVQA---TRQEVVFLAK 375
++ L L++KE + + L K D L++ + + ++QV + E +
Sbjct: 859 SKVEELSQALSQKELEITKMDQLLLEKKRDVETLQQTIEEKDQQVTEISFSMTEKMVQLN 918
Query: 376 ELSDAVNVRDRTMADLHTARLENEKVKKQLADAVAELKLNAMKKDQDKT--------DTL 427
E ++ V +T+ + E+ KK+ + E+ + +K++ D+ + L
Sbjct: 919 EEKFSLGVEIKTLKEQLNLLSRAEEAKKEQVEEDNEVS-SGLKQNYDEMSPAGQISKEEL 977
Query: 428 EHE---LRREVEDLKLRLQMAADHYKEKFKECQRLQKQINKLSDQSANNNNVFTKKTGNQ 484
+HE L++E E K +LQ A + KE + RL++++ L D+S + + G
Sbjct: 978 QHEFDLLKKENEQRKRKLQAALINRKELLQRVSRLEEELANLKDESKKEIPLSETERGEV 1037
Query: 485 QKVNDASVNTDPATSASTVDV----KPSPSAAEADFDIVTKGQVCEMTKEIADKTEKYNK 540
++ + ++ ++ ++ K + S E + + K ++ +++A + +
Sbjct: 1038 EEDKENKEYSEKCVTSKCQEIEIYLKQTISEKEVELQHIRK----DLEEKLAAEEQFQAL 1093
Query: 541 CKQLLQDEKAKCNK 554
KQ+ Q + K N+
Sbjct: 1094 VKQMNQTLQDKTNQ 1107
Score = 57.4 bits (137), Expect = 5e-08
Identities = 114/590 (19%), Positives = 217/590 (36%), Gaps = 115/590 (19%)
Query: 171 LEKETAQLREQVGRMERELNHEKERCDQLQAEQKGLTEVTQSLKMENEEFKKRFSDATSK 230
+E E +L +V EL + E QLQ + +SLK + E + K
Sbjct: 1314 IEAEKVELELKVSSTTSELTKKSEEVFQLQEQINKQGLEIESLKTVSHEAEVHAESLQQK 1373
Query: 231 AHQLEEDIVSVTHKAIEKETELDSLKDKLKKAQHEREQLECQLKTEKDEKELYKVHLKNT 290
+ I + H EL D+L+K ++E+ L + EKE ++
Sbjct: 1374 LESSQLQIAGLEHLR-----ELQPKLDELQKLISKKEEDVSYLSGQLSEKEAALTKIQTE 1428
Query: 291 EIENTKLMSEVQTLKNLDGNKESVITHFKEEIGRLQLCLAE--------------KENLQ 336
IE L+ + T + + E I +LQ+ L E K+ +Q
Sbjct: 1429 IIEQEDLIKALHTQLEMQAKEHD------ERIKQLQVELCEMKQKPEEIGEESRAKQQIQ 1482
Query: 337 RTFLLTTSSKEDTC----FLKEQLRKA--------------EEQVQATRQEVVFLAKELS 378
R S+++ L+E+L A E QV A +E + L+
Sbjct: 1483 RKLQAALISRKEALKENKSLQEELSLARGTIERLTKSLADVESQVSAQNKEKDTVLGRLA 1542
Query: 379 DAVNVRDRTMADLHTARLENEKV-----------------KKQLADAVAELKLNAMKKD- 420
RD+ + ++ + LEN+ + K++L + LK + + +
Sbjct: 1543 LLQEERDKLITEMDRSLLENQSLSSSCESLKLALEGLTEDKEKLVKEIESLKSSKIAEST 1602
Query: 421 --QDKTDTLEHE------------------------LRREVEDLKLRLQMAADHYKEKFK 454
Q+K L+ E +R+E ++L +L+ + KE K
Sbjct: 1603 EWQEKHKELQKEYEILLQSYENVSNEAERIQHVVEAVRQEKQELYGKLRSTEANKKETEK 1662
Query: 455 ECQRLQKQINKLSDQSANNNNVFTKKTGNQQKVNDASVNTDPATSASTVDVKPSPSAAEA 514
+ Q ++++ ++ ++ F K QQK+ + D + +V P+ A+
Sbjct: 1663 QLQEAEQEMEEMKEKMRK----FAK--SKQQKILELEEENDRLRA----EVHPAGDTAKE 1712
Query: 515 DFDIVTKGQVCEMTKEIADKTEKYNKCKQLLQDEKAKCNKYADELAKMELKWKEQVKIAE 574
+ + M +E+ +Y + Q ++ + ++E+ +LK + + +++
Sbjct: 1713 CMETLLSSN-ASMKEELERVKMEYETLSKKFQSLMSEKDSLSEEV--QDLKHQIEGNVSK 1769
Query: 575 NVKLELAEVQDNYKELKRSLENPAERKMEGQNSQSPQCFKTCSEQNGYVLTLSNAQPVLQ 634
LE E DN + + E Q+S S TCSE + P +
Sbjct: 1770 QANLEATEKHDNQTNVTEEGTQSIPGETEEQDSLSMSTRPTCSE----------SVPSAK 1819
Query: 635 YGNPYASQETRDGADGAFYPDEIQRPPVRVPSWGLEDNVVCSQPARNFSR 684
NP S++ + Y +I + R+ GLE+ Q + FS+
Sbjct: 1820 SANPAVSKDFSSHDEINNYLQQIDQLKERIA--GLEEE---KQKNKEFSQ 1864
Score = 55.1 bits (131), Expect = 3e-07
Identities = 89/400 (22%), Positives = 163/400 (40%), Gaps = 53/400 (13%)
Query: 123 SSPVEELLTMEDEGNSDMLVVTTKAGLLELKIEKTMKEKEELLKLIAVLEKETAQLREQV 182
SS + + +E+E K G +E K++K +K L ++ ET E+V
Sbjct: 2649 SSSQKRIAELEEELVCVQKEAAKKVGEIEDKLKKELKH---LHHDAGIMRNETETAEERV 2705
Query: 183 GRMERELNHEKERCDQLQAEQKGLTEVTQSLKMENEEFKKRFSDATSKAHQLEEDIVSVT 242
+ R+L +++ + E KGLT QS F + S + E
Sbjct: 2706 AELARDLVEMEQKLLMVTKENKGLTAQIQS-------FGRSMSSLQNSRDHANE------ 2752
Query: 243 HKAIEKETELDSLKDKLKKAQHEREQLECQ--LKTEKDEKELYKVHLKNTEIENTKLMSE 300
ELD LK K + E QL+ Q L E+D N+ EN+ +S
Sbjct: 2753 --------ELDELKRKYDASLKELAQLKEQGLLNRERDALLSETAFSMNSTEENS--LSH 2802
Query: 301 VQTLKNLDGNKESVITHFKEEIGRLQLCLAEKENLQRTFLLTTSSKEDTCFLKEQLRKAE 360
++ L +K+ + H + L+ + ++ + + ++ E+ RK+E
Sbjct: 2803 LEKLNQQLLSKDEQLLHLSSQ---LEDSYNQVQSFSKAMASLQNERDHLWNELEKFRKSE 2859
Query: 361 E-------QVQATRQEVVFLAKELSDAVNVRDRTMADLHTARLENEKVKKQLADAVAELK 413
E Q + EV L K +S N RDR + +L + + ++ +++ + + LK
Sbjct: 2860 EGKQRSAAQPSTSPAEVQSLKKAMSSLQNDRDRLLKELKNLQQQYLQINQEITE-LHPLK 2918
Query: 414 LNAMKKDQDKT---DTLEHELRRE-----VEDLKLRLQMAADHYKEKFKECQRLQKQINK 465
+++ QDKT ++ ELR+E E +LR++ ++ E+ + Q L I+
Sbjct: 2919 AQ-LQEYQDKTKAFQIMQEELRQENLSWQHELHQLRMEKSSWEIHERRMKEQYLM-AISD 2976
Query: 466 LSDQSANNNNVFTKKTGNQQKVNDASV----NTDPATSAS 501
Q ++ N+ + + + V P TSAS
Sbjct: 2977 KDQQLSHLQNLIRELRSSSSQTQPLKVQYQRQASPETSAS 3016
Score = 53.1 bits (126), Expect = 1e-06
Identities = 100/533 (18%), Positives = 205/533 (38%), Gaps = 78/533 (14%)
Query: 141 LVVTTKAGLLELKIEKTMKEKEELLKLIAVLEKETAQ---LREQVGRMERELNHEKERCD 197
+V +A + +L++ E++ L E +TA L EQ+ + E + + +
Sbjct: 758 MVTELRAQVKQLEMNLAEAERQRRLDY----ESQTAHDNLLTEQIHSLSIEAKSKDVKIE 813
Query: 198 QLQAEQKGL-------TEVTQSLKMENEEFKKRFSDATSKAHQLEEDIVSVTHKAIEKET 250
LQ E + + + +SL+ + + + + + + + ++ +KE
Sbjct: 814 VLQNELDDVQLQFSEQSTLIRSLQSQLQNKESEVLEGAERVRHISSKVEELSQALSQKEL 873
Query: 251 ELDSLKDKLKKAQHEREQLECQLKTEKDEKELYKVHLKNTEI------ENTKLMSEVQTL 304
E+ + L + + + E L+ Q EKD+ ++ ++ TE E L E++TL
Sbjct: 874 EITKMDQLLLEKKRDVETLQ-QTIEEKDQ-QVTEISFSMTEKMVQLNEEKFSLGVEIKTL 931
Query: 305 K---NLDGNKESVITHFKEEIGRLQLCLAEKENLQRTFLLTTSSKEDTCFLKEQLRKAEE 361
K NL E EE + L K+N SKE+ + L+K E
Sbjct: 932 KEQLNLLSRAEEAKKEQVEEDNEVSSGL--KQNYDEMSPAGQISKEELQHEFDLLKKENE 989
Query: 362 QVQATRQEVVFLAKELSDAVNVRDRTMADLHTARLENEKVKKQLADAVAELKLNAMKKDQ 421
Q + Q + KEL V+ + +A+L + + + V E K N ++
Sbjct: 990 QRKRKLQAALINRKELLQRVSRLEEELANLKDESKKEIPLSETERGEVEEDKENKEYSEK 1049
Query: 422 ---DKTDTLEHELRREVEDLKLRLQMAADHYKEKF---KECQRLQKQINKLSDQSANNNN 475
K +E L++ + + ++ LQ +EK ++ Q L KQ+N+ N +
Sbjct: 1050 CVTSKCQEIEIYLKQTISEKEVELQHIRKDLEEKLAAEEQFQALVKQMNQTLQDKTNQID 1109
Query: 476 VFTKKTGNQQKV--------NDASVNTDPATSASTVDVKPSPSAAEADFD---------- 517
+ + Q + DAS A TV + P + + +
Sbjct: 1110 LLQAEISENQAIIQKLITSNTDASDGDSVALVKETVVISPPCTGSSEHWKPELEEKILAL 1169
Query: 518 --------------------IVTKGQVCE--MTKEIADKTEKYNKCKQLLQDEKAKCNKY 555
I+ K Q E + +E+ + + YN+ ++ ++ +
Sbjct: 1170 EKEKEQLQKKLQEALTSRKAILKKAQEKERHLREELKQQKDDYNRLQEQFDEQSKENENI 1229
Query: 556 ADELAKMELKWKEQVKIAENVKLELAEVQDNYKELKRSLENPAERKMEGQNSQ 608
D+L +++++ +E + + KL + Q++ LE P + E ++Q
Sbjct: 1230 GDQLRQLQIQVRESI----DGKLPSTDQQESCSSTP-GLEEPLFKATEQHHTQ 1277
Score = 53.1 bits (126), Expect = 1e-06
Identities = 115/614 (18%), Positives = 243/614 (39%), Gaps = 142/614 (23%)
Query: 126 VEELLTMEDEGNSDMLVVTTKAGLLELKIEKTMKEKEELLKLIAVLEKETAQLREQVGRM 185
+E LL+ E+E N +LE + +K + + +L++ + ++KE Q + Q+
Sbjct: 2413 LENLLSQEEEENI----------VLEEENKKAVDKTNQLMETLKTIKKENIQQKAQLDSF 2462
Query: 186 ERE---LNHEKERC--DQLQAEQKGLT------EVTQSLKMENEEFKKRF-------SDA 227
+ L ++++R D Q E++ L+ ++ Q EN + K+ D
Sbjct: 2463 VKSMSSLQNDRDRIVGDYQQLEERHLSIILEKDQLIQEAAAENNKLKEEIRGLRSHMDDL 2522
Query: 228 TSKAHQLEEDIVS--------VTHK----------AIEKETELDS----LKDKLKKAQHE 265
S+ +L+ +++ +T K +++ EL++ L++KLK+++
Sbjct: 2523 NSENAKLDAELIQYREDLNQVITIKDSQQKQLLEVQLQQNKELENKYAKLEEKLKESEEA 2582
Query: 266 REQLECQLKTEKDEKELYKVHLKNTEIENTKLMSEVQTLKNLD--GNKESVITHFKEEIG 323
E L ++EK+ +++ ++ ++L +V L+ G + + +EE+
Sbjct: 2583 NEDLRRSFNALQEEKQDLSKEIESLKVSISQLTRQVTALQEEGTLGLYHAQLKVKEEEVH 2642
Query: 324 RL----------------QLCLAEKENLQRTFLLTTSSKE-------DTCFLKEQLRKAE 360
RL +L +KE ++ + K+ D ++ + AE
Sbjct: 2643 RLSALFSSSQKRIAELEEELVCVQKEAAKKVGEIEDKLKKELKHLHHDAGIMRNETETAE 2702
Query: 361 EQVQATRQEVVFLAKEL---------------------SDAVNVRDRTMADLHTARLENE 399
E+V +++V + ++L S N RD +L + + +
Sbjct: 2703 ERVAELARDLVEMEQKLLMVTKENKGLTAQIQSFGRSMSSLQNSRDHANEELDELKRKYD 2762
Query: 400 KVKKQLADAVAELKLN----------AMKKDQDKTDTLEH--ELRREVEDLKLRLQMAAD 447
K+LA + LN A + + ++L H +L +++ +L +
Sbjct: 2763 ASLKELAQLKEQGLLNRERDALLSETAFSMNSTEENSLSHLEKLNQQLLSKDEQLLHLSS 2822
Query: 448 HYKEKFKECQRLQKQINKLS---DQSANNNNVFTKKTGNQQKVNDASVNTDPATSASTVD 504
++ + + Q K + L D N F K +Q+ + A +T PA S
Sbjct: 2823 QLEDSYNQVQSFSKAMASLQNERDHLWNELEKFRKSEEGKQR-SAAQPSTSPAEVQS--- 2878
Query: 505 VKPSPSAAEADFDIVTK------GQVCEMTKEIA-------------DKTEKYNKCKQLL 545
+K + S+ + D D + K Q ++ +EI DKT+ + ++ L
Sbjct: 2879 LKKAMSSLQNDRDRLLKELKNLQQQYLQINQEITELHPLKAQLQEYQDKTKAFQIMQEEL 2938
Query: 546 QDEKAKCNKYADELAKMELKW-------KEQVKIAENVK-LELAEVQDNYKELKRSLENP 597
+ E +L + W KEQ +A + K +L+ +Q+ +EL+ S
Sbjct: 2939 RQENLSWQHELHQLRMEKSSWEIHERRMKEQYLMAISDKDQQLSHLQNLIRELRSSSSQT 2998
Query: 598 AERKMEGQNSQSPQ 611
K++ Q SP+
Sbjct: 2999 QPLKVQYQRQASPE 3012
Score = 51.6 bits (122), Expect = 3e-06
Identities = 65/325 (20%), Positives = 147/325 (45%), Gaps = 33/325 (10%)
Query: 155 EKTMKEKEELLKLIAVLEKETAQLREQVGRMERELNHEKERCDQLQAEQKG----LTEVT 210
E+ ++ +++L ++ ++ QL+++ ++ E + +L+ K L +
Sbjct: 52 ERLAYAEQLVVELKDIIRQKDVQLQQKDEALQEERKAADNKIKKLKLHAKAKLTSLNKYI 111
Query: 211 QSLKMEN-------EEFKKRFSDATSKAHQLEEDIVSVTHKAIEKETELDSLKDKLKKAQ 263
+ +K + + +++ S + + E +I + HK EKE + +L+ +L +AQ
Sbjct: 112 EEMKAQGGTVLPTEPQSEEQLSKHDKSSTEEEMEIEKIKHKLQEKEELISTLQAQLTQAQ 171
Query: 264 HEREQLECQLKTEKDEKELYKVHLKNTEIENTKLMSEVQTLKNLDGNKESVITHFKEEIG 323
E+ Q TE +E + K L+ E + L +++ + ++ + K+
Sbjct: 172 AEQ---PAQSSTEMEEFVMMKQQLQEKEEFISTLQAQLSQTQAEQAAQQ--VVREKDARF 226
Query: 324 RLQLCLAEKENLQRTFLLTTSSKEDTCFLKEQLRKAEEQVQATRQEVVFLAKELSDAVNV 383
Q+ L E E LQ L T + +T ++++LR + +++ + +V A+ V
Sbjct: 227 ETQVRLHEDELLQ----LVTQADVET-EMQQKLRVLQRKLEEHEESLVGRAQ-------V 274
Query: 384 RDRTMADLHTARLENEKVKKQLADAVAELKL--NAMKKDQDKTDTLEHELRREVEDLKL- 440
D +L A N+ + +QL AE N ++ +++++ L ++ EV + KL
Sbjct: 275 VDLLQQELTAAEQRNQILSQQLQQMEAEHNTLRNTVETEREESKILLEKMELEVAERKLS 334
Query: 441 --RLQMAADHYKEKFKECQRLQKQI 463
LQ H E+F++ + Q ++
Sbjct: 335 FHNLQEEMHHLLEQFEQAGQAQAEL 359
Score = 45.8 bits (107), Expect = 2e-04
Identities = 94/499 (18%), Positives = 195/499 (39%), Gaps = 54/499 (10%)
Query: 149 LLELKIEKTMKEKEELLKLIAVLEKETAQLREQVGRMERELNHEKERCDQLQAEQKGLTE 208
+L ++++ E L + +E+ L E +ME E+ K LQ E L E
Sbjct: 291 ILSQQLQQMEAEHNTLRNTVETEREESKILLE---KMELEVAERKLSFHNLQEEMHHLLE 347
Query: 209 VTQSLKMENEEFKKRFSDATSKAHQLEEDIVSVTHKAIEKE-TELDSLKDKLKK-----A 262
+ E + R+S A + H+ E + + +++K EL S D LK
Sbjct: 348 QFEQAGQAQAELESRYS-ALEQKHKAEMEEKTSHILSLQKTGQELQSACDALKDQNSKLL 406
Query: 263 QHEREQLECQLKT-EKDEKELYKVHLKNTEIENTKLMSEVQTLKNL---DGNKESVITHF 318
Q + EQ +T ++ E +L + + ++ N + + +T D E
Sbjct: 407 QDKNEQAVQSAQTIQQLEDQLQQKSKEISQFLNRLPLQQHETASQTSFPDVYNEGTQAVT 466
Query: 319 KEEIGRLQLCLAEKENLQRTFLLTTSSKED-----------TCFLKEQLRKAEEQVQATR 367
+E I LQ + E EN + LL++ E+ L+ Q R E + +
Sbjct: 467 EENIASLQKRVVELENEKGALLLSSIELEELKAENEKLSSQITLLEAQNRTGEADREVSE 526
Query: 368 QEVVFLAKELSDAV-----NVRDRTMADLHTARLENEKVKKQLADAVAELKLNAMKKDQD 422
+V +A + S + +V + T + H K+ + +A LKL K +
Sbjct: 527 ISIVDIANKRSSSAEESGQDVLENTFSQKHKELSVLLLEMKEAQEEIAFLKLQLQGKRAE 586
Query: 423 KTD--TLEHELRREVED---LKLRLQMAADHYKEKFKECQRLQKQINKLSDQSANNNNVF 477
+ D L+ + +++E +++++ + + F + + + + A+ +
Sbjct: 587 EADHEVLDQKEMKQMEGEGIAPIKMKVFLEDTGQDFPLMPNEESSLPAVEKEQASTEH-- 644
Query: 478 TKKTGNQQKVNDASVNTDPATSASTVDVKPSPSAAEADFDIV--TKGQVCEM-------- 527
+T + +NDA V + P + D + K Q+ E+
Sbjct: 645 QSRTSEEISLNDAGVELKSTKQDGDKSLSAVPDIGQCHQDELERLKSQILELELNFHKAQ 704
Query: 528 ---TKEIADKTEKYNKCKQLLQDEKAKCNKYADELAKMELKWKEQVKIAENVKLELAEVQ 584
K + +K ++ + QL+++ K + + + +E+ ++ VK EL+ V
Sbjct: 705 EIYEKNLDEKAKEISNLNQLIEEFKKNADNNSSAFTALS---EERDQLLSQVK-ELSMVT 760
Query: 585 DNYKELKRSLENPAERKME 603
+ ++K+ N AE + +
Sbjct: 761 ELRAQVKQLEMNLAEAERQ 779
>gi|110611903 myosin, heavy polypeptide 4, skeletal muscle [Homo
sapiens]
Length = 1939
Score = 84.3 bits (207), Expect = 4e-16
Identities = 112/519 (21%), Positives = 235/519 (45%), Gaps = 52/519 (10%)
Query: 126 VEELLTMEDEGNSDMLVVTTKAGLLELKIEKTMKEKEELLKLIAVLEKETAQLREQVGRM 185
V E E+E N+++ T K LE + + K+ ++L +A +EKE +V +
Sbjct: 926 VTERAEDEEEINAEL---TAKKRKLEDECSELKKDIDDLELTLAKVEKEKHATENKVKNL 982
Query: 186 ERELNHEKERCDQLQAEQKGLTEVTQ----SLKMENEEFKKRFSDATSKAHQLEEDIVSV 241
E+ E +L E+K L E Q L+ME E+ + A +K Q +D+
Sbjct: 983 TEEMAGLDETIAKLTKEKKALQEAHQQTLDDLQME-EDKVNTLTKAKTKLEQQVDDLEGS 1041
Query: 242 THKAIEKETELDSLKDKLKKAQHEREQLECQLKTEKDEKELYKVHLKNTEIENTKLMSEV 301
+ EK+ +D + K K + E + TE D+++L + LK E E + L ++
Sbjct: 1042 LEQ--EKKLCMDLERAKRKLEGDLKLAQESTMDTENDKQQLNE-KLKKKEFEMSNLQGKI 1098
Query: 302 QTLKNLDGNKESVITHFKEEIGRLQLCLAE-KENLQRTFLLTTSSKEDTCFLKEQLRKAE 360
+ +++++ +++I LQ + E +E ++ +++ L +L +
Sbjct: 1099 E-------DEQALAIQLQKKIKELQARIEELEEEIEAERASRAKAEKQRSDLSRELEEIS 1151
Query: 361 EQVQ----ATRQEVVFLAKELSDAVNVRDRTMADLHTARLENE----KVKKQLADAVAEL 412
E+++ AT ++ K ++ +R DL + L++E ++K+ AD+VAEL
Sbjct: 1152 ERLEEAGGATSAQIEMNKKREAEFQKMR----RDLEESTLQHEATAAALRKKHADSVAEL 1207
Query: 413 --KLNAMKKDQDKTDTLEHELRREVEDLKLRLQMAADHYKEKFKECQRLQKQINKLSDQS 470
+++++++ + K + + EL+ E+ DL ++ + K C+ L+ Q++++ +
Sbjct: 1208 GEQIDSLQRVKQKLEKEKSELKMEINDLASNMETVSKAKANFEKMCRTLEDQLSEIKTKE 1267
Query: 471 ANNNNVFTKKTGNQQKVNDASVNTDPATSASTVDVKPSPSAAEADFDIVTKGQVCEMTKE 530
+ N+ A ++T+ + +D K + + + Q+ E+ ++
Sbjct: 1268 EEQQRLI-----NELSAQKARLHTESGEFSRQLDEKDAMVSQLSRGKQAFTQQIEELKRQ 1322
Query: 531 IADKTEKYNKCKQLLQDEKAKCN----KYADEL-AKMELK---WKEQVKIAE-NVKLELA 581
+ ++T+ + LQ + C+ +Y +E AK EL+ K ++A+ K E
Sbjct: 1323 LEEETKAKSTLAHALQSARHDCDLLREQYEEEQEAKAELQRGMSKANSEVAQWRTKYETD 1382
Query: 582 EVQ--DNYKELKRSLE---NPAERKMEGQNSQSPQCFKT 615
+Q + +E K+ L AE +E NS+ KT
Sbjct: 1383 AIQRTEELEEAKKKLAQRLQDAEEHVEAVNSKCASLEKT 1421
Score = 73.6 bits (179), Expect = 7e-13
Identities = 96/474 (20%), Positives = 200/474 (42%), Gaps = 39/474 (8%)
Query: 150 LELKIEKTMKEKEELLKLIAVLEKETAQLREQVGRMERELNHEKERCDQLQAEQKGLTEV 209
LE ++ + ++EE +LI L + A+L + G R+L+ + QL ++ T+
Sbjct: 1256 LEDQLSEIKTKEEEQQRLINELSAQKARLHTESGEFSRQLDEKDAMVSQLSRGKQAFTQQ 1315
Query: 210 TQSLKMENEEFKKRFSDATSKAHQLEEDIVSVTHKAIEKETELDSLKDKLKKAQHEREQL 269
+ LK + EE K S D + + E++ L+ + KA E Q
Sbjct: 1316 IEELKRQLEEETKAKSTLAHALQSARHDCDLLREQYEEEQEAKAELQRGMSKANSEVAQW 1375
Query: 270 ECQLKTE----KDEKELYKVHL--------KNTEIENTKLMSEVQTLKNLDGNKESVITH 317
+ +T+ +E E K L ++ E N+K S +T + L E ++
Sbjct: 1376 RTKYETDAIQRTEELEEAKKKLAQRLQDAEEHVEAVNSKCASLEKTKQRLQNEVEDLMI- 1434
Query: 318 FKEEIGRLQLCLAEKENLQRTFLLTTSSKEDTCFLKEQLRKAEEQVQATRQEVVFLAKEL 377
++ R + QR F + K++ + + +++A+++E L+ EL
Sbjct: 1435 ---DVERSNAACIALDKKQRNFDKVLAE------WKQKYEETQAELEASQKESRSLSTEL 1485
Query: 378 SDAVNVRDRTMADLHTARLENEKVKKQLADAVAELKLNAMKKDQDKTDTLEHELRREVED 437
N + ++ L T + EN+ ++++++D ++ K + + ++ +L E +
Sbjct: 1486 FKVKNAYEESLDHLETLKRENKNLQQEISDLTEQIAEGG--KHIHELEKVKKQLDHEKSE 1543
Query: 438 LKLRLQMAADHYKEKFKECQRLQKQINKLSDQ----SANNNNVFTKKTGNQQKVNDASVN 493
L+ L+ A + + + R+Q ++N++ + A + + N +V ++ +
Sbjct: 1544 LQTSLEEAEASLEHEEGKILRIQLELNQVKSEIDRKIAEKDEELDQLKRNHLRVVESMQS 1603
Query: 494 TDPATSASTVDVKPSPSAAEADFDIVTKGQVCEMTKEIADKTEKYNKCKQLLQDEKAKCN 553
T A S D E D + + + Q+ ++ A+ + +L+D +
Sbjct: 1604 TLDAEIRSRNDALRIKKKMEGDLNEM-EIQLNHANRQAAEALRNLRNTQGILKDTQL--- 1659
Query: 554 KYADELAKMELKWKEQVKIAE-NVKLELAEVQDNYKELKRSLENPAE-RKMEGQ 605
+ D+ + + KEQ+ + E L AEV+ EL+ SLE RKM Q
Sbjct: 1660 -HLDDAIRGQDDLKEQLAMVERRANLMQAEVE----ELRASLERTERGRKMAEQ 1708
Score = 72.0 bits (175), Expect = 2e-12
Identities = 103/484 (21%), Positives = 202/484 (41%), Gaps = 60/484 (12%)
Query: 153 KIEKTMKEKEELLKLIAVLEKETAQLREQVGRMERELNHEKERCD-------QLQAEQKG 205
++ KT +++EL + + L +E L+ QV L +ERCD QL+A+ K
Sbjct: 866 ELAKTEAKRKELEEKMVTLMQEKNDLQLQVQAEADALADAEERCDQLIKTKIQLEAKIKE 925
Query: 206 LTEVTQSLKMENEEFKKRFSDATSKAHQLEEDIVSVTHKAIEKETELDSLKDKLKKAQHE 265
+TE + + N E + + +L++DI + + E E + ++K+K E
Sbjct: 926 VTERAEDEEEINAELTAKKRKLEDECSELKKDIDDLELTLAKVEKEKHATENKVKNLTEE 985
Query: 266 REQL-ECQLKTEKDEKELYKVH---LKNTEIENTKLMSEVQTLKNLDGNKESVITHFKEE 321
L E K K++K L + H L + ++E K+ + + L+ + + ++E
Sbjct: 986 MAGLDETIAKLTKEKKALQEAHQQTLDDLQMEEDKVNTLTKAKTKLEQQVDDLEGSLEQE 1045
Query: 322 IGRLQLCL---AEKENLQRTFLLTTSSKEDTCFLKEQLRKAEEQVQATRQEVVFLAKELS 378
+LC+ K L+ L S DT K+QL + L K+
Sbjct: 1046 ---KKLCMDLERAKRKLEGDLKLAQESTMDTENDKQQLNEK-------------LKKKEF 1089
Query: 379 DAVNVRDRTMADLHTARLENEKVKKQLADAVAEL--KLNAMKKDQDKTDTLEHELRREVE 436
+ N++ + + D ++ +K K+L + EL ++ A + + K + +L RE+E
Sbjct: 1090 EMSNLQGK-IEDEQALAIQLQKKIKELQARIEELEEEIEAERASRAKAEKQRSDLSRELE 1148
Query: 437 DLKLRLQMAA-------DHYKEKFKECQRLQKQINKLSDQSANNNNVFTKKTGNQQKVND 489
++ RL+ A + K++ E Q++++ + + + Q KK + V +
Sbjct: 1149 EISERLEEAGGATSAQIEMNKKREAEFQKMRRDLEESTLQHEATAAALRKK--HADSVAE 1206
Query: 490 ASVNTDPATSASTVDVKPSPSAAEADFDIVTKGQVCEMTKEIADKTEKYNKCKQLLQDEK 549
D S V K +E +I ++A E +K K + +
Sbjct: 1207 LGEQID---SLQRVKQKLEKEKSELKMEI----------NDLASNMETVSKAK---ANFE 1250
Query: 550 AKCNKYADELAKMELKWKEQVKIAENVKLELAEVQDNYKELKRSLENPAERKMEGQNSQS 609
C D+L++++ K +EQ ++ + + A + E R L+ + M Q S+
Sbjct: 1251 KMCRTLEDQLSEIKTKEEEQQRLINELSAQKARLHTESGEFSRQLDE--KDAMVSQLSRG 1308
Query: 610 PQCF 613
Q F
Sbjct: 1309 KQAF 1312
Score = 60.1 bits (144), Expect = 8e-09
Identities = 104/521 (19%), Positives = 201/521 (38%), Gaps = 81/521 (15%)
Query: 143 VTTKAGLLELKIEKTMKEKEELLKLIAVLEKETAQLREQVGRMERELNHEKERCDQLQAE 202
V +K LE ++ E E+L+ + L ++ ++ L K++ ++ QAE
Sbjct: 1411 VNSKCASLEKTKQRLQNEVEDLMIDVERSNAACIALDKKQRNFDKVLAEWKQKYEETQAE 1470
Query: 203 QKGLTEVTQS---------------------LKMENEEFKKRFSDATSK-------AHQL 234
+ + ++S LK EN+ ++ SD T + H+L
Sbjct: 1471 LEASQKESRSLSTELFKVKNAYEESLDHLETLKRENKNLQQEISDLTEQIAEGGKHIHEL 1530
Query: 235 EEDIVSVTHKAIEKETELDSLKDKLKKAQHE--REQLEC-QLKTEKDEK---------EL 282
E+ + H+ E +T L+ + L+ + + R QLE Q+K+E D K +L
Sbjct: 1531 EKVKKQLDHEKSELQTSLEEAEASLEHEEGKILRIQLELNQVKSEIDRKIAEKDEELDQL 1590
Query: 283 YKVHLKNTEIENTKLMSEVQT-------LKNLDGNKESVITHFKEEIGRLQLCLAEKENL 335
+ HL+ E + L +E+++ K ++G+ + + L N
Sbjct: 1591 KRNHLRVVESMQSTLDAEIRSRNDALRIKKKMEGDLNEMEIQLNHANRQAAEALRNLRNT 1650
Query: 336 QRTFLLTTSSKEDTC----FLKEQLRKAEEQVQATRQEVVFLAKELSDAVNVRDRTMADL 391
Q T +D LKEQL E + + EV L L R R MA+
Sbjct: 1651 QGILKDTQLHLDDAIRGQDDLKEQLAMVERRANLMQAEVEELRASLER--TERGRKMAE- 1707
Query: 392 HTARLENEKVKKQLADAVAELKL-----NAMKKDQDKTDTLEHELRREVEDLKLRLQMAA 446
++L DA ++L ++ + K +T +++ E+ED+ + A
Sbjct: 1708 -----------QELLDASERVQLLHTQNTSLINTKKKLETDISQIQGEMEDIVQEARNAE 1756
Query: 447 DHYKEKFKECQRLQKQINKLSDQSANNNNVFTKKTGNQQKVNDASVNTDPATSASTVDVK 506
+ K+ + + +++ K D SA+ + K +Q V D + D A + K
Sbjct: 1757 EKAKKAITDAAMMAEELKKEQDTSAHLERM---KKNMEQTVKDLQLRLDEAEQLALKGGK 1813
Query: 507 PSPSAAEA-------DFDIVTKGQVCEMTKEIADKTEKYNKCKQLLQDEKAKCNKYADEL 559
EA + + K V E K + + + ++++ + D +
Sbjct: 1814 KQIQKLEARVRELESEVESEQKHNV-EAVKGLRKHERRVKELTYQTEEDRKNILRLQDLV 1872
Query: 560 AKMELKWKEQVKIAENVKLELAEVQDNYKELKRSLENPAER 600
K++ K K + AE + + +++L+ LE ER
Sbjct: 1873 DKLQTKVKAYKRQAEEAEEQSNVNLAKFRKLQHELEEAKER 1913
Score = 58.9 bits (141), Expect = 2e-08
Identities = 77/366 (21%), Positives = 156/366 (42%), Gaps = 50/366 (13%)
Query: 255 LKDKLKKAQHEREQLECQLKTEKDEKELYKVHLKNTEIENTKLMSEVQTLKNLDGNKESV 314
+K LK A+ E+E + + EK ++EL K K E+E E +
Sbjct: 840 IKPLLKSAETEKEMANMKEEFEKTKEELAKTEAKRKELE------------------EKM 881
Query: 315 ITHFKEEIGRLQLCLAEKENLQRTFLLTTSSKEDTCFLKEQLRKAEEQVQATRQEVVFLA 374
+T +E+ AE + L + E+ C +QL K + Q++A +EV A
Sbjct: 882 VTLMQEKNDLQLQVQAEADAL--------ADAEERC---DQLIKTKIQLEAKIKEVTERA 930
Query: 375 ---KELSDAVNVRDRTMADLHTARLENEKVKKQLADAVAELKLNAMKKDQDKTDTLEHEL 431
+E++ + + R + D E ++KK + D EL L ++K++ T+ L
Sbjct: 931 EDEEEINAELTAKKRKLED------ECSELKKDIDD--LELTLAKVEKEKHATENKVKNL 982
Query: 432 RREVEDLKLRLQMAADHYKEKFKECQRLQKQINKLSDQSANNNNVFTKKTGNQQKVNDAS 491
E+ L + A KEK + Q+ ++ L + N + KT +Q+V+D
Sbjct: 983 TEEMAGLD---ETIAKLTKEKKALQEAHQQTLDDLQMEEDKVNTLTKAKTKLEQQVDDLE 1039
Query: 492 VNTDPATSASTVDVKPSPSAAEADFDIV------TKGQVCEMTKEIADKTEKYNKCKQLL 545
+ + +D++ + E D + T+ ++ +++ K + + + +
Sbjct: 1040 GSLEQEKKL-CMDLERAKRKLEGDLKLAQESTMDTENDKQQLNEKLKKKEFEMSNLQGKI 1098
Query: 546 QDEKAKCNKYADELAKMELKWKEQVKIAENVKLELAEVQDNYKELKRSLENPAERKMEGQ 605
+DE+A + ++ +++ + +E + E + A+ + +L R LE +ER E
Sbjct: 1099 EDEQALAIQLQKKIKELQARIEELEEEIEAERASRAKAEKQRSDLSRELEEISERLEEAG 1158
Query: 606 NSQSPQ 611
+ S Q
Sbjct: 1159 GATSAQ 1164
Score = 58.2 bits (139), Expect = 3e-08
Identities = 89/457 (19%), Positives = 202/457 (44%), Gaps = 40/457 (8%)
Query: 212 SLKMENEEFKKRFSDATSKAHQLEEDIVSVTHK----AIEKETELDSLKDKLKKAQH--- 264
++K E E+ K+ + +K +LEE +V++ + ++ + E D+L D ++
Sbjct: 855 NMKEEFEKTKEELAKTEAKRKELEEKMVTLMQEKNDLQLQVQAEADALADAEERCDQLIK 914
Query: 265 EREQLECQLK--TEK--DEKEL---YKVHLKNTEIENTKLMSEVQ----TLKNLDGNK-- 311
+ QLE ++K TE+ DE+E+ + E E ++L ++ TL ++ K
Sbjct: 915 TKIQLEAKIKEVTERAEDEEEINAELTAKKRKLEDECSELKKDIDDLELTLAKVEKEKHA 974
Query: 312 -ESVITHFKEEIGRLQLCLA----EKENLQRTFLLTTS----SKEDTCFLKEQLRKAEEQ 362
E+ + + EE+ L +A EK+ LQ T ++ L + K E+Q
Sbjct: 975 TENKVKNLTEEMAGLDETIAKLTKEKKALQEAHQQTLDDLQMEEDKVNTLTKAKTKLEQQ 1034
Query: 363 VQATRQEVVFLAKELSDAVNVRDRTMADLHTAR---LENEKVKKQLADAV--AELKLNAM 417
V + K D + + DL A+ ++ E K+QL + + E +++ +
Sbjct: 1035 VDDLEGSLEQEKKLCMDLERAKRKLEGDLKLAQESTMDTENDKQQLNEKLKKKEFEMSNL 1094
Query: 418 KKDQDKTDTLEHELRREVEDLKLRLQMAADHYKEKFKECQRLQKQINKLSDQSANNNNVF 477
+ + L +L++++++L+ R++ + + + + +KQ + LS + +
Sbjct: 1095 QGKIEDEQALAIQLQKKIKELQARIEELEEEIEAERASRAKAEKQRSDLSRELEEISERL 1154
Query: 478 TKKTGNQQKVNDASVNTDPATSASTVDVKPSPSAAEADFDIVTKGQVCEMTKEIADKTEK 537
+ G + + + D++ S EA + K + + E+ ++ +
Sbjct: 1155 EEAGGATSAQIEMNKKREAEFQKMRRDLEESTLQHEATAAALRK-KHADSVAELGEQIDS 1213
Query: 538 YNKCKQLLQDEKAKCNKYADELA-KMELKWKEQV---KIAENVKLELAEVQDNYKELKRS 593
+ KQ L+ EK++ ++LA ME K + K+ ++ +L+E++ +E +R
Sbjct: 1214 LQRVKQKLEKEKSELKMEINDLASNMETVSKAKANFEKMCRTLEDQLSEIKTKEEEQQRL 1273
Query: 594 LENPAERKMEGQNSQSPQCFKTCSEQNGYVLTLSNAQ 630
+ + +K +++S + + E++ V LS +
Sbjct: 1274 INELSAQKAR-LHTESGEFSRQLDEKDAMVSQLSRGK 1309
>gi|6715600 golgi autoantigen, golgin subfamily a, 4 [Homo sapiens]
Length = 2230
Score = 83.6 bits (205), Expect = 7e-16
Identities = 108/509 (21%), Positives = 222/509 (43%), Gaps = 51/509 (10%)
Query: 127 EELLTMEDEGNSDMLVVTTKAGLLELKIEKTMKE--KEELLKLIAVLEKETA----QLRE 180
E++ T+E + + + + ++ ++ MK+ +E++ KL + EKE A +L +
Sbjct: 439 EQIKTIEKTSEEERISLQQELSRVKQEVVDVMKKSSEEQIAKLQKLHEKELARKEQELTK 498
Query: 181 QVGRMERELNH------EKERCDQLQAEQKGLTEVTQSLKMENEEFKKR--FSDATSKAH 232
++ ERE EK + + L+ Q+ E +SL +E E +K+ +++ +K
Sbjct: 499 KLQTREREFQEQMKVALEKSQSEYLKISQE--KEQQESLALEELELQKKAILTESENKLR 556
Query: 233 QLEEDIVSVTHKAIEKETELDSLKDKLKKAQHEREQLECQLKTEKDE--KEL-YKVHLKN 289
L+++ + + +E E+ SL+ L++ +++ + L L+ EK++ KE+ V
Sbjct: 557 DLQQEAETYRTRILELES---SLEKSLQENKNQSKDLAVHLEAEKNKHNKEITVMVEKHK 613
Query: 290 TEIENTKLMSEVQTLKNLDGNKESVITHFKEEIGRLQLCLAEKENLQRTFLLTTSSKEDT 349
TE+E+ K + + L K+ T ++ L EK ++ LL
Sbjct: 614 TELESLKHQQDALWTEKLQVLKQQYQTEMEK--------LREKCEQEKETLLKDKEIIFQ 665
Query: 350 CFLKEQLRKAEEQVQATRQEVVFLAKELSDAVNVRDRTMADLHTARLENEKVKKQLADAV 409
++E K E++ + E+ L+ ELS+ + R + +L + + +K+K++L +
Sbjct: 666 AHIEEMNEKTLEKLDVKQTELESLSSELSEVLKARHKLEEELSVLKDQTDKMKQELEAKM 725
Query: 410 AELKL-------NAMKKDQDKTDTLEHELRREVEDLKLRLQMAADHYKEKFKECQRLQKQ 462
E K + +K+ + E L+ ++ L+L L+ H KE + L+
Sbjct: 726 DEQKNHHQQQVDSIIKEHEVSIQRTEKALKDQINQLELLLKERDKHLKEHQAHVENLEAD 785
Query: 463 INKLS---DQSANNNNVFTKKTGNQQKVNDASVNTDPATSASTVDVKPSPSAAEADFDIV 519
I + Q++ +VF Q A+ A ++ E + ++
Sbjct: 786 IKRSEGELQQASAKLDVF-------QSYQSATHEQTKAYEEQLAQLQQKLLDLETERILL 838
Query: 520 TKGQVCEMTKEIADKTEKYNKCKQLLQDEKAKCNKYADELAKMELKWKEQVKIAENVKLE 579
TK QV E+ + D + + K +QD + K E ME K K ++ E+ +
Sbjct: 839 TK-QVAEVEAQKKDVCTELDAHKIQVQDLMQQLEKQNSE---MEQKVKSLTQVYESKLED 894
Query: 580 LAEVQDNYKELKRSLENPAERKMEGQNSQ 608
+ Q+ K++ EN + EGQ +
Sbjct: 895 GNKEQEQTKQILVEKENMILQMREGQKKE 923
Score = 68.6 bits (166), Expect = 2e-11
Identities = 119/555 (21%), Positives = 223/555 (40%), Gaps = 77/555 (13%)
Query: 121 RASSPVEELLTMEDEGNSDMLVVTTKAGLLELKIEKTMKEKEELLKLIAV-LEKETA-QL 178
R E++LT+E++ S + TK LE + ++K KEE LK + LE E+A +L
Sbjct: 1579 RVKEAEEKILTLENQVYSMKAELETKKKELE-HVNLSVKSKEEELKALEDRLESESAAKL 1637
Query: 179 REQVGRMERELNH-EKERCDQLQAEQKGLTEVTQSLKMENEEFKKRFSDATSKAHQLEED 237
E + E+++ +K+ Q++ +++ + T+S E + + + H LEE
Sbjct: 1638 AELKRKAEQKIAAIKKQLLSQMEEKEEQYKKGTES---HLSELNTKLQEREREVHILEEK 1694
Query: 238 IVSVTHKAIEKETELDSLKDKLKKAQHEREQLECQLKTEKDEKELYKVHLKNTEIENTKL 297
+ SV ++ + ET + K A E+E+ + Q +K +E V +N E KL
Sbjct: 1695 LKSV--ESSQSETLIVPRSAKNVAAYTEQEEADSQGCVQKTYEEKISVLQRNLT-EKEKL 1751
Query: 298 MSEVQTLKNLDGNKESVITHFKEE-----------------------IGRLQLCLAEKEN 334
+ V K +E+V +HF+ IG LQ L EK
Sbjct: 1752 LQRVGQEK-----EETVSSHFEMRCQYQERLIKLEHAEAKQHEDQSMIGHLQEELEEKNK 1806
Query: 335 LQRTFLLTTSSKE---DTCFLKEQLRKAEEQVQATRQEVVFLAKELSDAVNVRDRTMA-- 389
+ KE + K+ L + VQ T QE + L + D +
Sbjct: 1807 KYSLIVAQHVEKEGGKNNIQAKQNLENVFDDVQKTLQEKELTCQILEQKIKELDSCLVRQ 1866
Query: 390 -DLHTARLENEKVKKQLADAVAELK--------LNAMKKDQDKTDTLEHELRREVE---- 436
++H +E K + A+ ++ L +++ K+ ++ +L +E
Sbjct: 1867 KEVHRVEMEELTSKYEKLQALQQMDGRNKPTELLEENTEEKSKSHLVQPKLLSNMEAQHN 1926
Query: 437 DLKLRLQMAADHYKEKFKECQRLQKQINKLSDQSANNNNVFTKKTGNQQKVNDASVNTDP 496
DL+ +L A ++ KE RLQK + L + + KK +Q++ +
Sbjct: 1927 DLEFKLAGAEREKQKLGKEIVRLQKDLRMLRKEHQQELEIL-KKEYDQEREEKIKQEQED 1985
Query: 497 ATSASTVDVKPSPSAAEADFDIVTKGQVCEMT-KEIADKTEKYNKCKQLLQDEKAKCNKY 555
+K E + + K Q EMT KE +K ++ +LL+ + + N+
Sbjct: 1986 LELKHNSTLK--QLMREFNTQLAQKEQELEMTIKETINKAQEVE--AELLESHQEETNQL 2041
Query: 556 ADELAK---------------MELKWKEQVKIAENVKLELAEVQDNYKELKRSLENPAER 600
++A+ ++ + +E +++ +L E+Q Y++ ENP
Sbjct: 2042 LKKIAEKDDDLKRTAKRYEEILDAREEEMTAKVRDLQTQLEELQKKYQQKLEQEENPGND 2101
Query: 601 KMEGQNSQSPQCFKT 615
+ Q+ KT
Sbjct: 2102 NVTIMELQTQLAQKT 2116
Score = 67.0 bits (162), Expect = 6e-11
Identities = 121/556 (21%), Positives = 221/556 (39%), Gaps = 104/556 (18%)
Query: 151 ELKIEKTMKEKEELLKLIAV-------LEKETAQLREQVGRMERELNHEKERCDQLQAEQ 203
E+++++ +E EL + I + + KE L+E+ + + LN +E+ Q A
Sbjct: 1063 EIQLQEKEQEVAELKQKILLFGCEKEEMNKEITWLKEEGVKQDTTLNELQEQLKQKSAHV 1122
Query: 204 KGLTEVTQSLKMENEEFKKRFSDATSKAHQLEEDIVSVTHKAIEKETELDSLKDKLKKAQ 263
L + LK E+ + + + + L+E +V + A E + ++ L KLK
Sbjct: 1123 NSLAQDETKLKAHLEKLEVDLNKSLKENTFLQEQLVELKMLAEEDKRKVSELTSKLKTTD 1182
Query: 264 HEREQLECQLKTEKDEKELYKVHLKNTEI------------ENTKLMSEVQT--LKNLDG 309
E + L+ EK K L L+ ++ + T+ + E +T L N+
Sbjct: 1183 EEFQSLKS--SHEKSNKSLEDKSLEFKKLSEELAIQLDICCKKTEALLEAKTNELINISS 1240
Query: 310 NKESVI-----------THFKEEI-----------GRLQLCLAEKENLQRTFLLTT---- 343
+K + I T KE + +L+ E+ L +F T
Sbjct: 1241 SKTNAILSRISHCQHRTTKVKEALLIKTCTVSELEAQLRQLTEEQNTLNISFQQATHQLE 1300
Query: 344 -------SSKEDTCFL---KEQLRK--AEEQVQATRQE--VVFLAKELSDAVNVRDRTMA 389
S K D L KE L+K +Q A+ +E + L KELS+ +N
Sbjct: 1301 EKENQIKSMKADIESLVTEKEALQKEGGNQQQAASEKESCITQLKKELSENINAVTLMKE 1360
Query: 390 DLHTARLENEKVKKQLADAVAEL--------KLNAMKKDQDKTDTLEHELRREVEDLKLR 441
+L ++E + KQL D +L K A+ + + D + EL +V+DL +
Sbjct: 1361 ELKEKKVEISSLSKQLTDLNVQLQNSISLSEKEAAISSLRKQYDEEKCELLDQVQDLSFK 1420
Query: 442 LQMAADHYKEKFKECQRLQKQINKLSDQSANNNNVFTKKTGNQQKVNDASVNTDPATSAS 501
+ + KEK +++ NK S+ + FT+ +Q V + + +
Sbjct: 1421 VDTLS---KEKISALEQVDDWSNKFSEWKKKAQSRFTQ---HQNTVKELQIQLE------ 1468
Query: 502 TVDVKPSPSAAEADFDIVTKGQVCEMTKEIADKTEKYNKCKQLLQDEKAKCNKYADELAK 561
S A E D Q+ + +E+ + ++++ K ++D+K+K K L +
Sbjct: 1469 ----LKSKEAYEKD------EQINLLKEELDQQNKRFDCLKGEMEDDKSKMEKKESNL-E 1517
Query: 562 MELKWKEQVKIAE--------NVKLE-LAEVQDNYKELKRSLENPAERKMEGQNSQSPQC 612
ELK + +I E +++E L EV NY + K +K++ +
Sbjct: 1518 TELK-SQTARIMELEDHITQKTIEIESLNEVLKNYNQQKDIEHKELVQKLQHFQELGEEK 1576
Query: 613 FKTCSEQNGYVLTLSN 628
E +LTL N
Sbjct: 1577 DNRVKEAEEKILTLEN 1592
Score = 62.4 bits (150), Expect = 2e-09
Identities = 94/477 (19%), Positives = 202/477 (42%), Gaps = 47/477 (9%)
Query: 150 LELKIEKTMKEKEELLK-----LIAVLEKETAQLREQVGRMERELNHEKERC-------D 197
L ++++ K+ E LL+ LI + +T + ++ + KE
Sbjct: 1213 LAIQLDICCKKTEALLEAKTNELINISSSKTNAILSRISHCQHRTTKVKEALLIKTCTVS 1272
Query: 198 QLQAEQKGLTEVTQSLKMENEEFKKRFSDATSKAHQLEEDIVS-VTHK-AIEKE------ 249
+L+A+ + LTE +L + ++ + + ++ ++ DI S VT K A++KE
Sbjct: 1273 ELEAQLRQLTEEQNTLNISFQQATHQLEEKENQIKSMKADIESLVTEKEALQKEGGNQQQ 1332
Query: 250 --TELDSLKDKLKKAQHEREQLECQLKTEKDEKELYKVHLKNTEIENTKLMSEVQTLKNL 307
+E +S +LKK E +K E EK KV + + + T L ++Q +L
Sbjct: 1333 AASEKESCITQLKKELSENINAVTLMKEELKEK---KVEISSLSKQLTDLNVQLQNSISL 1389
Query: 308 DGNKESVITHFKEEIGRLQLCLAEKENLQRTFLLTTSSKEDTCFLKE------QLRKAEE 361
KE+ I+ +++ + C + +F + T SKE L++ + + ++
Sbjct: 1390 S-EKEAAISSLRKQYDE-EKCELLDQVQDLSFKVDTLSKEKISALEQVDDWSNKFSEWKK 1447
Query: 362 QVQATRQEVVFLAKELSDAVNVRDRTMADL-HTARLENEKVKKQLADAVAELKLNAMKKD 420
+ Q+ + KEL + ++ + + L E++ +Q + + M+ D
Sbjct: 1448 KAQSRFTQHQNTVKELQIQLELKSKEAYEKDEQINLLKEELDQQ--NKRFDCLKGEMEDD 1505
Query: 421 QDKTDTLEHELRREVEDLKLRLQMAADHYKEKFKECQRLQKQINKLSDQSANNNNVFTKK 480
+ K + E L E++ R+ DH +K E + L + + + Q + +K
Sbjct: 1506 KSKMEKKESNLETELKSQTARIMELEDHITQKTIEIESLNEVLKNYNQQKDIEHKELVQK 1565
Query: 481 TGNQQKVNDASVNTDPATSASTVDVKPSPSAAEADFDIVTKGQVCEMTKEIADKTEKYNK 540
+ Q++ + N + ++ + +A+ + K ++ + + K E+
Sbjct: 1566 LQHFQELGEEKDNRVKEAEEKILTLENQVYSMKAELE-TKKKELEHVNLSVKSKEEELKA 1624
Query: 541 CKQLLQDEKAKCNKYADELAKM-ELKWKEQVKIAENVKLELAEVQDNYKELKRSLEN 596
+ L+ E A AK+ ELK K + KIA K L+++++ ++ K+ E+
Sbjct: 1625 LEDRLESESA---------AKLAELKRKAEQKIAAIKKQLLSQMEEKEEQYKKGTES 1672
Score = 62.0 bits (149), Expect = 2e-09
Identities = 100/511 (19%), Positives = 215/511 (42%), Gaps = 69/511 (13%)
Query: 146 KAGLLELKIEKTMKEKEELLKLIAVLEKETAQLREQVGRMERELN---------HEKERC 196
K L +E + KEK+ K++ + + +A + + V R+E H +E
Sbjct: 982 KKELENTALELSQKEKQFNAKMLEMAQANSAGISDAVSRLETNQKEQIESLTEVHRRELN 1041
Query: 197 DQLQAEQKGLTEVTQSL-----------KMENEEFKKRFSDATSKAHQLEEDIVSVTHKA 245
D + +K L + + L + E E K++ + ++ ++I + +
Sbjct: 1042 DVISIWEKKLNQQAEELQEIHEIQLQEKEQEVAELKQKILLFGCEKEEMNKEITWLKEEG 1101
Query: 246 IEKETELDSLKDKLK-KAQHEREQLECQLKTEKDEKELYKVHLKNTEIENTKLMSEVQTL 304
++++T L+ L+++LK K+ H + + K K E +V L + ENT L ++ L
Sbjct: 1102 VKQDTTLNELQEQLKQKSAHVNSLAQDETKL-KAHLEKLEVDLNKSLKENTFLQEQLVEL 1160
Query: 305 KNL---DGNKESVITHFKEEIGRLQLCLAEKENLQRTFLLTTSSKEDTCF----LKEQL- 356
K L D K S +T +L+ E ++L+ + + S ED L E+L
Sbjct: 1161 KMLAEEDKRKVSELT------SKLKTTDEEFQSLKSSHEKSNKSLEDKSLEFKKLSEELA 1214
Query: 357 -------RKAEEQVQATRQEVVFLAKELSDAVNVRDRTMADLHTARLENEKVKKQLADAV 409
+K E ++A E++ ++ ++A+ R + T +++ + K +
Sbjct: 1215 IQLDICCKKTEALLEAKTNELINISSSKTNAILSR-ISHCQHRTTKVKEALLIKTCTVSE 1273
Query: 410 AELKLNAMKKDQDKTDTLEHELRREVEDLKLRLQMAADHYKEKFKECQRLQKQ------- 462
E +L + ++Q+ + + ++E+ + +++ + E + LQK+
Sbjct: 1274 LEAQLRQLTEEQNTLNISFQQATHQLEEKENQIKSMKADIESLVTEKEALQKEGGNQQQA 1333
Query: 463 -------INKLSDQSANNNNVFT--KKTGNQQKVNDASVNTDPATSASTVDVKPSPSAAE 513
I +L + + N N T K+ ++KV +S++ + V ++ S S +E
Sbjct: 1334 ASEKESCITQLKKELSENINAVTLMKEELKEKKVEISSLSKQ--LTDLNVQLQNSISLSE 1391
Query: 514 ADFDIVT-KGQVCEMTKEIADKTEKYNKCKQLLQDEKAKCNKYADELAKMELKWKEQVKI 572
+ I + + Q E E+ D+ + + L EK + D+ + +WK++
Sbjct: 1392 KEAAISSLRKQYDEEKCELLDQVQDLSFKVDTLSKEKISALEQVDDWSNKFSEWKKK--- 1448
Query: 573 AENVKLELAEVQDNYKELKRSLENPAERKME 603
+ + Q+ KEL+ LE ++ E
Sbjct: 1449 ---AQSRFTQHQNTVKELQIQLELKSKEAYE 1476
Score = 55.1 bits (131), Expect = 3e-07
Identities = 102/482 (21%), Positives = 219/482 (45%), Gaps = 67/482 (13%)
Query: 150 LELKIEKTMKEKEELLKLIAVLEKETAQLREQVGRMERELNHEKERCDQLQAEQKGLTEV 209
LE I+++ E ++ + V + + EQ E +L +++ L+ E+ LT+
Sbjct: 782 LEADIKRSEGELQQASAKLDVFQSYQSATHEQTKAYEEQLAQLQQKLLDLETERILLTK- 840
Query: 210 TQSLKMENEEFKKRFSDATSKAHQLE-EDIVSVTHKA-IEKETELDSL----KDKLKKAQ 263
++ E +K+ AH+++ +D++ K E E ++ SL + KL+
Sbjct: 841 ----QVAEVEAQKKDVCTELDAHKIQVQDLMQQLEKQNSEMEQKVKSLTQVYESKLEDGN 896
Query: 264 HEREQLECQLKTEKDEK--ELYKVHLKNTEIENTKLMSEVQTLKNLDGNKESVITHFKEE 321
E+EQ + Q+ EK+ ++ + K EI KL ++ ++ L+ E T FK +
Sbjct: 897 KEQEQTK-QILVEKENMILQMREGQKKEIEILTQKLSAKEDSIHILN---EEYETKFKNQ 952
Query: 322 IGRLQLCLAEKENLQRTFLLTTSSKEDTCFLKEQLRKAEEQVQATRQEVVFLAKEL---- 377
+++ + + +Q T L + LK++L ++ +++E F AK L
Sbjct: 953 EKKMEKVKQKAKEMQET--LKKKLLDQEAKLKKELENT--ALELSQKEKQFNAKMLEMAQ 1008
Query: 378 SDAVNVRDRTMADLHTARLE-----NEKVKKQLADAVA--ELKLNAMKKDQDKTDTLE-H 429
+++ + D ++ L T + E E +++L D ++ E KLN ++ + ++
Sbjct: 1009 ANSAGISD-AVSRLETNQKEQIESLTEVHRRELNDVISIWEKKLNQQAEELQEIHEIQLQ 1067
Query: 430 ELRREVEDLKLRLQMAADHYKEKFKECQRLQKQ-------INKLSDQ----SANNNNVFT 478
E +EV +LK ++ + +E KE L+++ +N+L +Q SA+ N++
Sbjct: 1068 EKEQEVAELKQKILLFGCEKEEMNKEITWLKEEGVKQDTTLNELQEQLKQKSAHVNSLAQ 1127
Query: 479 KKTGNQQKVNDASVNTDPATSAST------VDVKPSPSAAEADFDIVTKGQVCEMTKEIA 532
+T + + V+ + + +T V++K AE D K +V E+T ++
Sbjct: 1128 DETKLKAHLEKLEVDLNKSLKENTFLQEQLVELK---MLAEED-----KRKVSELTSKLK 1179
Query: 533 DKTEKY-------NKCKQLLQDEKAKCNKYADELA-KMELKWKEQVKIAENVKLELAEVQ 584
E++ K + L+D+ + K ++ELA ++++ K+ + E EL +
Sbjct: 1180 TTDEEFQSLKSSHEKSNKSLEDKSLEFKKLSEELAIQLDICCKKTEALLEAKTNELINIS 1239
Query: 585 DN 586
+
Sbjct: 1240 SS 1241
Score = 53.5 bits (127), Expect = 7e-07
Identities = 86/397 (21%), Positives = 167/397 (42%), Gaps = 40/397 (10%)
Query: 119 QFRASSPVEELLTMEDEGNSDMLVVTT--KAGLLELKIEKTMKEKE------ELLKLIAV 170
Q +A+S E +T + S+ + T K L E K+E + K+ +L I++
Sbjct: 1330 QQQAASEKESCITQLKKELSENINAVTLMKEELKEKKVEISSLSKQLTDLNVQLQNSISL 1389
Query: 171 LEKETA--QLREQVGRMERELNHEKE----RCDQLQAEQKGLTEVTQSLKMENEEFKK-- 222
EKE A LR+Q + EL + + + D L E+ E + E+KK
Sbjct: 1390 SEKEAAISSLRKQYDEEKCELLDQVQDLSFKVDTLSKEKISALEQVDDWSNKFSEWKKKA 1449
Query: 223 --RFSDATSKAHQLEEDIVSVTHKAIEKETELDSLKDKLKKAQHEREQLECQLKTEKDEK 280
RF+ + +L+ + + +A EK+ +++ LK++L + ++ +C +D+K
Sbjct: 1450 QSRFTQHQNTVKELQIQLELKSKEAYEKDEQINLLKEEL---DQQNKRFDCLKGEMEDDK 1506
Query: 281 ELYKVHLKNTEIENTKLMSEVQTLKNLDGNKESVITHFKEEIGRL--QLCLAEKENLQRT 338
+ N E E + + L++ K I E + Q + KE +Q+
Sbjct: 1507 SKMEKKESNLETELKSQTARIMELEDHITQKTIEIESLNEVLKNYNQQKDIEHKELVQKL 1566
Query: 339 FLLTTSSKEDTCFLKEQLRK---AEEQVQATRQEVVFLAKELSD---AVNVRDRTMADLH 392
+E +KE K E QV + + E+ KEL +V ++ + L
Sbjct: 1567 QHFQELGEEKDNRVKEAEEKILTLENQVYSMKAELETKKKELEHVNLSVKSKEEELKALE 1626
Query: 393 TARLENE------KVKKQLADAVAELKLNAMKKDQDKTDTLEHELRREVEDLKLRLQ--- 443
RLE+E ++K++ +A +K + + ++K + + + +L +LQ
Sbjct: 1627 D-RLESESAAKLAELKRKAEQKIAAIKKQLLSQMEEKEEQYKKGTESHLSELNTKLQERE 1685
Query: 444 MAADHYKEKFKECQRLQKQINKLSDQSANNNNVFTKK 480
+EK K + Q + + +SA N +T++
Sbjct: 1686 REVHILEEKLKSVESSQSE-TLIVPRSAKNVAAYTEQ 1721
Score = 52.4 bits (124), Expect = 2e-06
Identities = 111/549 (20%), Positives = 228/549 (41%), Gaps = 72/549 (13%)
Query: 108 KGEIRGASTPFQFRASSPVEELLTMEDEGNSDMLVVTTKAGLLELKIEKTM--------- 158
K ++R S FR SP++E L ++ +++ L L ++ +
Sbjct: 64 KLQLRVPSVESLFR--SPIKESL-FRSSSKESLVRTSSRESLNRLDLDSSTASFDPPSDM 120
Query: 159 -KEKEELLKLIAVLEKETAQLREQVGRMERELNHEKERCDQL-------QAEQKGLTEVT 210
E E+L+ L KE QL +++ RMER L+ + + +L Q E+K L +
Sbjct: 121 DSEAEDLVGNSDSLNKE--QLIQRLRRMERSLSSYRGKYSELVTAYQMLQREKKKLQGIL 178
Query: 211 -----QSLKMENEEFKKRFSDATSKAHQLEEDIVSVTHK---AIEKETELDSLKDKLKKA 262
+SL+ E ++ D +K H EE S+ K +T++ LK +L+
Sbjct: 179 SQSQDKSLRRIAELREELQMDQQAKKHLQEEFDASLEEKDQYISVLQTQVSLLKQRLRNG 238
Query: 263 QHEREQLECQLKTEKDEKELYKVHLKNTEIENTKLMSEVQTLKNLDGNKESVITHFKEEI 322
+ L+ + E + K +N E + ++ + ++K L+ ++ V K +
Sbjct: 239 PMNVDVLKPLPQLEPQAEVFTKE--ENPESDGEPVVEDGTSVKTLETLQQRV----KRQE 292
Query: 323 GRLQLCLAEKENLQRTFLLTTSSKEDTCFLKEQLRKAEEQVQATRQ----EVVFLAKELS 378
L+ C ++ + L TS KE L+EQL + ++++ + E L +L
Sbjct: 293 NLLKRCKETIQSHKEQCTLLTSEKEA---LQEQLDERLQELEKIKDLHMAEKTKLITQLR 349
Query: 379 DAVNV-----RDRTMADLHTARLENEKVKKQLADAVAELKLNAMK---KDQDKTDTLEHE 430
DA N+ +D+ M T R +E ++ + + +A+L+ + + ++ + E
Sbjct: 350 DAKNLIEQLEQDKGMVIAETKRQMHETLEMK-EEEIAQLRSRIKQMTTQGEELREQKEKS 408
Query: 431 LRREVEDLKLRLQMAADHYKEKFKECQRLQKQINKLSDQSANNNNVFTKKTGN-QQKVND 489
R E+L+ L A + + K + +QI + S ++ +Q+V D
Sbjct: 409 ERAAFEELEKALSTAQKTEEARRKLKAEMDEQIKTIEKTSEEERISLQQELSRVKQEVVD 468
Query: 490 ASVNTDPATSASTVDVKPSPSAAEADFDIVTKGQVCEMTKEIADKTEKYNK-CKQLLQDE 548
+ A + A + E+TK++ + ++ + K L+
Sbjct: 469 VMKKSSEEQIAKLQKLHEKELARKEQ----------ELTKKLQTREREFQEQMKVALEKS 518
Query: 549 KAKCNKYADE--------LAKMELKWKEQVKIAENVKLELAEVQDNYKELKRSLENPAER 600
+++ K + E L ++EL+ K + +EN +L + + Y+ LE+ E+
Sbjct: 519 QSEYLKISQEKEQQESLALEELELQKKAILTESENKLRDLQQEAETYRTRILELESSLEK 578
Query: 601 KMEGQNSQS 609
++ +QS
Sbjct: 579 SLQENKNQS 587
Score = 52.4 bits (124), Expect = 2e-06
Identities = 93/489 (19%), Positives = 199/489 (40%), Gaps = 71/489 (14%)
Query: 150 LELKIEKTMKEKEELLKLIAVLEKETAQLREQVGRMERELNHEKERCDQLQAEQKG---- 205
LELK ++ ++ E++ L L+++ + G ME + + +++ L+ E K
Sbjct: 1467 LELKSKEAYEKDEQINLLKEELDQQNKRFDCLKGEMEDDKSKMEKKESNLETELKSQTAR 1526
Query: 206 -------LTEVTQSLKMENEEFKKRFSDATSKAHQLEEDIVSVTHKAIEKETELDSLKDK 258
+T+ T ++ NE K + +L + + EK+ + ++K
Sbjct: 1527 IMELEDHITQKTIEIESLNEVLKNYNQQKDIEHKELVQKLQHFQELGEEKDNRVKEAEEK 1586
Query: 259 LKKAQHEREQLECQLKTEKDEKELYKVHLKNTEIENTKLMSEVQT-----LKNLDGNKES 313
+ +++ ++ +L+T+K E E + +K+ E E L +++ L L E
Sbjct: 1587 ILTLENQVYSMKAELETKKKELEHVNLSVKSKEEELKALEDRLESESAAKLAELKRKAEQ 1646
Query: 314 VITHFKEEIGRLQLCLAEKENLQRTFLLTTSSKEDTCFLKEQLRKAE--------EQVQA 365
I K+++ L++ E + + T S K Q R+ E + V++
Sbjct: 1647 KIAAIKKQL------LSQMEEKEEQYKKGTESHLSELNTKLQEREREVHILEEKLKSVES 1700
Query: 366 TRQEVVFLAKELSDAVNVRDRTMADLHTARLENEKVKKQLADAVAELKLNAMKKD----- 420
++ E + + + + ++ AD V+K + ++ L+ N +K+
Sbjct: 1701 SQSETLIVPRSAKNVAAYTEQEEADSQGC------VQKTYEEKISVLQRNLTEKEKLLQR 1754
Query: 421 --QDKTDTL--EHELRREVEDLKLRLQMAADHYKEKFKECQRLQKQINKLS--------- 467
Q+K +T+ E+R + ++ ++L+ A E LQ+++ + +
Sbjct: 1755 VGQEKEETVSSHFEMRCQYQERLIKLEHAEAKQHEDQSMIGHLQEELEEKNKKYSLIVAQ 1814
Query: 468 --DQSANNNNVFTKKTGNQQKVNDASVNT--DPATSASTVDVKPSPSAAEADFDIVTKGQ 523
++ NN+ K+ N + V D T + + ++ K E D +V + +
Sbjct: 1815 HVEKEGGKNNIQAKQ--NLENVFDDVQKTLQEKELTCQILEQK----IKELDSCLVRQKE 1868
Query: 524 VCEMTKEIADKTEKYNKCKQLLQ-DEKAKCNKYADELAKMELKWKEQVKIAENVKLELAE 582
V + E+ + T KY K + L Q D + K EL + + K + + + L E
Sbjct: 1869 VHRV--EMEELTSKYEKLQALQQMDGRNK----PTELLEENTEEKSKSHLVQPKLLSNME 1922
Query: 583 VQDNYKELK 591
Q N E K
Sbjct: 1923 AQHNDLEFK 1931
Score = 51.6 bits (122), Expect = 3e-06
Identities = 63/234 (26%), Positives = 114/234 (48%), Gaps = 28/234 (11%)
Query: 150 LELKIEKTMKEKEELLKLIAVLEKETAQLREQVGRMEREL---NHEKERCDQLQAEQKGL 206
LE K+ +EK++L K I L+K+ LR++ + E E+ +++ER ++++ EQ+ L
Sbjct: 1928 LEFKLAGAEREKQKLGKEIVRLQKDLRMLRKE-HQQELEILKKEYDQEREEKIKQEQEDL 1986
Query: 207 -TEVTQSLKMENEEFKKRFSDATSKAHQLEEDIVSVTHKAIEKETELDSLKDKLKKAQHE 265
+ +LK EF + + K +LE I +KA E E EL L+ Q E
Sbjct: 1987 ELKHNSTLKQLMREFNTQLA---QKEQELEMTIKETINKAQEVEAEL------LESHQEE 2037
Query: 266 REQLECQLKTEKDE----KELYKVHLKNTEIENTKLMSEVQT-LKNLDGNKESVITHFKE 320
QL ++ + D+ + Y+ L E E T + ++QT L+ L + + +E
Sbjct: 2038 TNQLLKKIAEKDDDLKRTAKRYEEILDAREEEMTAKVRDLQTQLEELQKKYQQKLEQ-EE 2096
Query: 321 EIGRLQLCLAEKEN--LQRTFLLTTSSKEDTCF------LKEQLRKAEEQVQAT 366
G + + E + Q+T L++ S ++ F L+++L+K E+ V AT
Sbjct: 2097 NPGNDNVTIMELQTQLAQKTTLISDSKLKEQEFREQIHNLEDRLKKYEKNVYAT 2150
>gi|64085252 hypothetical protein LOC145508 [Homo sapiens]
Length = 1094
Score = 83.6 bits (205), Expect = 7e-16
Identities = 97/503 (19%), Positives = 208/503 (41%), Gaps = 63/503 (12%)
Query: 128 ELLTMEDEGNSDMLVVTTKAGLLELKIEKTMKEKEELLKLIAVLEKETAQLREQVGRMER 187
E + + D+ N ++ ++ + + ++ ++E E L E + ++ ++ +ER
Sbjct: 174 EQIRLGDDFNREL----SRRSRSDAETKRALEELTEKLNEAQKQEVVSDRVERRLQELER 229
Query: 188 ELNHEKE----RCDQLQAEQKGLTEVTQSLKMENEE----FKKRFSDATSKAHQLEEDIV 239
E+ E+E R DQL L E + + + +E K + ++ +QLE+++
Sbjct: 230 EMRTERELVERRQDQLGLMSLQLQEALKKQEAKADEHEGAIKNKLRQTETEKNQLEQELE 289
Query: 240 --------------SVTHKAIEKETELDSLKDKLKKAQHEREQLECQLKTEKDEKELYKV 285
++ H+ E T+L + K QH+ Q+ Q +DE+
Sbjct: 290 LSRRLLNQSEGSRETLLHQVEELRTQLTKAEGDRKGLQHQVSQISKQQSNYQDEQGEDWR 349
Query: 286 HLKNTEIENTKLMSEVQTLKNLDGNKESVITHFKEEIGRLQLCLAEKENLQRTFLLTTSS 345
+ E E L ++ L+ + + E+ ++ C+ K+
Sbjct: 350 FRRGVEREKQDLEKQMSDLR-----VQLNFSAMASELEEVKRCMERKD------------ 392
Query: 346 KEDTCFLKEQLRKAEEQVQATRQEVVFLAKELSDAVNVRDRTMADLHTARLENEKVKKQL 405
++ L Q+ +++ ++ + + L + N D A+ A L+ ++ +
Sbjct: 393 -KEKAHLASQVENLTRELENGEKQQLQMLDRLKEIQNHFDTCEAERKHADLQISELTRHA 451
Query: 406 ADAVAELKLNAMKKDQDKTDTLEHELRREVEDLKLRLQMAADHYKEKFKECQR-LQKQIN 464
DA + + + Q ++ L+ E + EDLKL+ Q + +K K K+ +R L+KQ
Sbjct: 452 EDATKQAERYLSELQQ--SEALKEEAEKRREDLKLKAQESIRQWKLKHKKLERALEKQSE 509
Query: 465 KLSDQSANNNNVFTKKTGNQQKVNDASVNTDPATSASTVDVKPSPSAAEADFDIVTKGQV 524
+ + + NN + +K D + ++ + + D++TK +
Sbjct: 510 TVDELTGKNNQILKEK--------------DELKTQLYAALQQIENLRKELNDVLTKRAL 555
Query: 525 CEMTKEIADKTEKYNKCKQLLQDEKAKCNKYADELAKMELKWKEQVKIAENVKLELAEVQ 584
E +E+ K EK K D + + D + ++E + K+Q KI +K+E A ++
Sbjct: 556 QE--EELHSKEEKLRDIKSHQADLELEVKNSLDTIHRLESELKKQSKIQSQMKVEKAHLE 613
Query: 585 DNYKELKRSLENPAERKMEGQNS 607
+ ELK+S + +E Q S
Sbjct: 614 EEIAELKKSQAQDKAKLLEMQES 636
Score = 68.2 bits (165), Expect = 3e-11
Identities = 71/325 (21%), Positives = 141/325 (43%), Gaps = 26/325 (8%)
Query: 160 EKEELLKLIAVLEKETAQLREQVGRMERELNHEK-ERCDQLQAEQKG-LTEVTQSLKMEN 217
++ E LK A +E +L+ Q + +L H+K ER + Q+E LT + E
Sbjct: 466 QQSEALKEEAEKRREDLKLKAQESIRQWKLKHKKLERALEKQSETVDELTGKNNQILKEK 525
Query: 218 EEFKKRFSDATSKAHQLEEDIVSVTHKAIEKETELDSLKDKLKKAQHEREQLECQLKTEK 277
+E K + A + L +++ V K +E EL S ++KL+ + + LE ++K
Sbjct: 526 DELKTQLYAALQQIENLRKELNDVLTKRALQEEELHSKEEKLRDIKSHQADLELEVKNSL 585
Query: 278 DEKELYKVHLKNTEIENTKLMSEVQTLKNLDGNKESVITHFKEEIGRLQLCLAEKENLQR 337
D + LK + +K+ S+++ K H +EEI L+ A+ +
Sbjct: 586 DTIHRLESELK----KQSKIQSQMKVEK----------AHLEEEIAELKKSQAQDK---A 628
Query: 338 TFLLTTSSKEDTCFLKEQLRKAEEQVQATRQEVVFLAKELSDAVNVRDRTMADLHTA-RL 396
L S +D ++ L + + ++ V+ +L+ RD A + T +L
Sbjct: 629 KLLEMQESIKDLSAIRADLANKLAEEERAKKAVLKDLSDLTAQAKSRDEETATIITQLKL 688
Query: 397 ENEKVKKQLADAVAELKLNAMKKDQDKTDTLEH------ELRREVEDLKLRLQMAADHYK 450
E + +++L D + L+ K +Q+ + ++H E + LK + K
Sbjct: 689 ERDVHQRELKDLTSSLQSVKTKHEQNIQELMKHFKKEKSEAENHIRTLKAESLEEKNMAK 748
Query: 451 EKFKECQRLQKQINKLSDQSANNNN 475
+ ++L+ Q ++L+++ N N
Sbjct: 749 IHRGQLEKLKSQCDRLTEELTQNEN 773
Score = 62.8 bits (151), Expect = 1e-09
Identities = 76/328 (23%), Positives = 157/328 (47%), Gaps = 41/328 (12%)
Query: 153 KIEKTMKEKEELLKLIAVLEKETAQLREQVGRMERELNHEKERCDQLQAEQKGLTEVTQS 212
K+ + + K+ +LK ++ L + E+ + +L E+ D Q E K LT QS
Sbjct: 650 KLAEEERAKKAVLKDLSDLTAQAKSRDEETATIITQLKLER---DVHQRELKDLTSSLQS 706
Query: 213 LKMENEE--------FKKRFSDA-----TSKAHQLEEDIVSVTHKA-IEK-ETELDSLKD 257
+K ++E+ FKK S+A T KA LEE ++ H+ +EK +++ D L +
Sbjct: 707 VKTKHEQNIQELMKHFKKEKSEAENHIRTLKAESLEEKNMAKIHRGQLEKLKSQCDRLTE 766
Query: 258 KLKKAQHEREQLECQLKTEKDEKELYKVHLKNTEIENTKLMSEVQ-----TLKNLDGNKE 312
+L + ++E ++L+ + + KD+ E + H+ + E E+ + M E + L L+ +E
Sbjct: 767 ELTQNENENKKLKLKYQCLKDQLEEREKHI-SIEEEHLRRMEEARLQLKDQLLCLETEQE 825
Query: 313 SVI------------THFKEEIGRLQLCLAEKENLQRTFLLTTSSKEDTCFLKEQLRKAE 360
S++ T K+ + +L++ + + SK +L E+L++ E
Sbjct: 826 SILGVIGKEIDAACKTFSKDSVEKLKVFSSGPDIHYDPHRWLAESKTKLQWLCEELKERE 885
Query: 361 EQVQATRQEVVFLAKELSDAVNVRDRTMADLHTARLENEKVKKQLADAVAELKLNAMKKD 420
+ + R +++ ++L N+ + ++L + E+ ++QL D + K + +++
Sbjct: 886 NREKNLRHQLMLCRQQLR---NLTENKESELQCLFQQIER-QEQLLDEIHREKRDLLEET 941
Query: 421 QDKTDTLEHELRREVEDLKLRLQMAADH 448
Q K + + L+ V L+ Q+A DH
Sbjct: 942 QRKDEEM-GSLQDRVIALETSTQVALDH 968
>gi|12667788 myosin, heavy polypeptide 9, non-muscle [Homo sapiens]
Length = 1960
Score = 82.8 bits (203), Expect = 1e-15
Identities = 119/508 (23%), Positives = 225/508 (44%), Gaps = 57/508 (11%)
Query: 159 KEKEELLKLIAVLEKETAQLREQVGRMERELNHEKERCDQLQAEQKGLTEVTQS---LKM 215
+++EE++ E+E ++RE+ E L + QL AE+ L E Q+ L
Sbjct: 842 RQEEEMM----AKEEELVKVREKQLAAENRLTEMETLQSQLMAEKLQLQEQLQAETELCA 897
Query: 216 ENEEFKKRFSDATSKAHQLEEDIVSVTHKAIEKETELDSLKDKLKKAQHEREQLECQLKT 275
E EE + R T+K +LEE + + E+E L+ + KK Q ++LE QL+
Sbjct: 898 EAEELRARL---TAKKQELEEICHDLEARVEEEEERCQHLQAEKKKMQQNIQELEEQLEE 954
Query: 276 EKDEKELYKVHLKNTEIENTKLMSEVQTLKNLDGNKESVITHFKEEIGRLQLCLAEKENL 335
E+ ++ ++ TE + KL E L++ + ++ I L E+E
Sbjct: 955 EESARQKLQLEKVTTEAKLKKLEEEQIILEDQNCKLAKEKKLLEDRIAEFTTNLTEEEEK 1014
Query: 336 QRTFLLTTSSKEDTCF--LKEQLRKAEEQ---VQATRQEVVFLAKELSDAVNVRDRTMAD 390
++ L +K + L+E+LR+ E+Q ++ TR+++ + +LSD + +A+
Sbjct: 1015 SKS-LAKLKNKHEAMITDLEERLRREEKQRQELEKTRRKLEGDSTDLSDQIAELQAQIAE 1073
Query: 391 LHTARLENEKVKKQLADAVAELKLNAMKKDQ--DKTDTLE---HELRREVEDLKLRLQMA 445
L +++ K +++L A+A ++ A +K+ K LE EL+ ++E + A
Sbjct: 1074 L---KMQLAKKEEELQAALARVEEEAAQKNMALKKIRELESQISELQEDLESERASRNKA 1130
Query: 446 ADHYKEKFKECQRLQKQINKLSDQSANNNNVFTKKTGNQQKVNDASVNTDPATSASTVDV 505
++ +E + L+ ++ D +A + +K+ +Q+VN + A T +
Sbjct: 1131 EKQKRDLGEELEALKTELEDTLDSTAAQQELRSKR---EQEVNILKKTLE--EEAKTHEA 1185
Query: 506 KPSPSAAEADFDIVTKGQVCEMTKEIADKTEK------------YNKCKQLLQ---DEKA 550
+ + + + E TK + EK N+ K LLQ D +
Sbjct: 1186 QIQEMRQKHSQAVEELAEQLEQTKRVKANLEKAKQTLENERGELANEVKVLLQGKGDSEH 1245
Query: 551 KCNKYADELAKMELKWKEQVKIAENVKLELAEVQDNYKELKRSLENPAERKMEGQNSQS- 609
K K +L ++++K+ E E V+ ELA D +L+ L+N + G SQS
Sbjct: 1246 KRKKVEAQLQELQVKFNE----GERVRTELA---DKVTKLQVELDN-----VTGLLSQSD 1293
Query: 610 PQCFKTCSEQNGYVLTLSNAQPVLQYGN 637
+ K + + L + Q +LQ N
Sbjct: 1294 SKSSKLTKDFSALESQLQDTQELLQEEN 1321
Score = 79.0 bits (193), Expect = 2e-14
Identities = 106/523 (20%), Positives = 220/523 (42%), Gaps = 69/523 (13%)
Query: 122 ASSPVEELLTMEDEGNSDMLVVTTKAGLLELKIEKTMKEKEELLKLIAVLEKETAQLREQ 181
A +E+ T + D+LV +EK K+ ++LL + + A+ R++
Sbjct: 1407 AYDKLEKTKTRLQQELDDLLVDLDHQRQSACNLEKKQKKFDQLLAEEKTISAKYAEERDR 1466
Query: 182 VGRMERELNHEK---ERCDQLQAEQKG-LTEVTQSLKMENEEFKKRFSDATSKAHQLEED 237
RE + R + EQK L + + + E E+ D H+LE+
Sbjct: 1467 AEAEAREKETKALSLARALEEAMEQKAELERLNKQFRTEMEDLMSSKDDVGKSVHELEKS 1526
Query: 238 IVSVTHKAIEKETELDSLKDKLK----------------KAQHEREQLECQLKTEKDEKE 281
++ + E +T+L+ L+D+L+ KAQ ER+ ++E+ +K+
Sbjct: 1527 KRALEQQVEEMKTQLEELEDELQATEDAKLRLEVNLQAMKAQFERDLQGRDEQSEEKKKQ 1586
Query: 282 LYK-VHLKNTEIENTKLMSEV---------QTLKNLDGNKESVITHFKEEIGRLQLCLAE 331
L + V E+E+ + + LK+L+ + +S + E I +L+ A+
Sbjct: 1587 LVRQVREMEAELEDERKQRSMAVAARKKLEMDLKDLEAHIDSANKNRDEAIKQLRKLQAQ 1646
Query: 332 KENLQRTFLLTTSSKEDTCFLKEQLRKAEEQVQATRQEVVFLAKELSDAVNVRDRTMADL 391
++ R T +S+E+ + Q ++ E+++++ E++ L +EL+ A
Sbjct: 1647 MKDCMRELDDTRASREE---ILAQAKENEKKLKSMEAEMIQLQEELAAA----------- 1692
Query: 392 HTARLENEKVKKQLADAVAE------LKLNAMKKDQDKTDTLEHELRREVEDLKLRLQMA 445
A+ + ++ + +LAD +A L L ++ + + LE EL E + +L
Sbjct: 1693 ERAKRQAQQERDELADEIANSSGKGALALEEKRRLEARIAQLEEELEEEQGNTEL----I 1748
Query: 446 ADHYKEKFKECQRLQKQINKLSDQSANNNNV--FTKKTGNQQKVN----DASVNTDPATS 499
D K+ + ++ +N + N N ++ + KV + +V + S
Sbjct: 1749 NDRLKKANLQIDQINTDLNLERSHAQKNENARQQLERQNKELKVKLQEMEGTVKSKYKAS 1808
Query: 500 ASTVDVKPSPSAAEADFDIVTKGQVCEMTKEIADKTEKYNKCKQLL---QDEKAKCNKYA 556
+ ++ K + + D + + C+ + +TEK K K +L DE+ +Y
Sbjct: 1809 ITALEAKIAQLEEQLDNETKERQAACKQVR----RTEK--KLKDVLLQVDDERRNAEQYK 1862
Query: 557 DELAKMELKWKEQVKIAENVKLELAEVQDNYKELKRSLENPAE 599
D+ K + K+ + E + E + ++L+R LE+ E
Sbjct: 1863 DQADKASTRLKQLKRQLEEAEEEAQRANASRRKLQRELEDATE 1905
Score = 75.5 bits (184), Expect = 2e-13
Identities = 102/504 (20%), Positives = 212/504 (42%), Gaps = 48/504 (9%)
Query: 124 SPVEELLTMEDEGNSDMLVVTTKAGLLELKIEKTMKEKEELLKLIAVLEKETAQLREQVG 183
S +++ + E N L ++TK +E + ++ EE + LEK+ A L QV
Sbjct: 1308 SQLQDTQELLQEENRQKLSLSTKLKQVEDEKNSFREQLEEEEEAKHNLEKQIATLHAQVA 1367
Query: 184 RMERELNHEKERCDQLQAEQKGLTEVTQSLKMENEE----FKKRFSDATSKAHQLEEDIV 239
M++++ + + ++ L + + L +EE + K T +L++ +V
Sbjct: 1368 DMKKKMEDSVGCLETAEEVKRKLQKDLEGLSQRHEEKVAAYDKLEKTKTRLQQELDDLLV 1427
Query: 240 SVTHKAIEKETELDSLKDKLKKAQHEREQLECQLKTEKD-------EKELYKVHLKNTEI 292
+ H+ + L+ + K + E + + + E+D EKE + L
Sbjct: 1428 DLDHQR-QSACNLEKKQKKFDQLLAEEKTISAKYAEERDRAEAEAREKETKALSLARALE 1486
Query: 293 ENTKLMSEVQTLKNLDGNKESVITHFKEEIGRLQLCLAEKENLQRTFLLTTSSKEDTCFL 352
E + +E++ L + + K+++G+ + E E +R ++ +
Sbjct: 1487 EAMEQKAELERLNKQFRTEMEDLMSSKDDVGK---SVHELEKSKRAL------EQQVEEM 1537
Query: 353 KEQLRKAEEQVQATRQEVVFLAKELSDAVNVRDRTMADLHTARLENEKVKKQLADAVAEL 412
K QL + E+++QAT + L L ++ + DL ++E+ KKQL V E+
Sbjct: 1538 KTQLEELEDELQATEDAKLRLEVNLQ---AMKAQFERDLQGRDEQSEEKKKQLVRQVREM 1594
Query: 413 --KLNAMKKDQDKTDTLEHELRREVEDLKLRLQMAADHYKEKFKECQRLQKQ----INKL 466
+L +K + +L +++DL+ + A + E K+ ++LQ Q + +L
Sbjct: 1595 EAELEDERKQRSMAVAARKKLEMDLKDLEAHIDSANKNRDEAIKQLRKLQAQMKDCMREL 1654
Query: 467 SDQSANNNNVFTKKTGNQQKVNDASVNTDPATSASTVDVKPSPSAAEADFDIVTKGQVCE 526
D A+ + + N++K+ + A + ++ +AAE K Q +
Sbjct: 1655 DDTRASREEILAQAKENEKKLK--------SMEAEMIQLQEELAAAER-----AKRQAQQ 1701
Query: 527 MTKEIADKTEKYNKCKQLLQDEKAKCNKYADELAKMELKWKEQVKIAE--NVKLELAEVQ 584
E+AD+ + L +EK + +A++E + +E+ E N +L+ A +Q
Sbjct: 1702 ERDELADEIANSSGKGALALEEKRRLEA---RIAQLEEELEEEQGNTELINDRLKKANLQ 1758
Query: 585 DNYKELKRSLENPAERKMEGQNSQ 608
+ +LE +K E Q
Sbjct: 1759 IDQINTDLNLERSHAQKNENARQQ 1782
Score = 65.5 bits (158), Expect = 2e-10
Identities = 123/583 (21%), Positives = 236/583 (40%), Gaps = 98/583 (16%)
Query: 126 VEELLTMEDEGNSDMLV--VTTKAGLLELKIE---------KTMKEKEELLKLIAVL--- 171
+EE L E+ + + VTT+A L +L+ E K KEK+ L IA
Sbjct: 948 LEEQLEEEESARQKLQLEKVTTEAKLKKLEEEQIILEDQNCKLAKEKKLLEDRIAEFTTN 1007
Query: 172 -------EKETAQLREQ----VGRMERELNHEKERCDQLQAEQKGLTEVTQSLKMENEEF 220
K A+L+ + + +E L E+++ +L+ ++ L + L + E
Sbjct: 1008 LTEEEEKSKSLAKLKNKHEAMITDLEERLRREEKQRQELEKTRRKLEGDSTDLSDQIAEL 1067
Query: 221 KKRFSD----ATSKAHQLEEDIVSVTHKAIEK----------ETELDSLKDKLKKAQHER 266
+ + ++ K +L+ + V +A +K E+++ L++ L+ + R
Sbjct: 1068 QAQIAELKMQLAKKEEELQAALARVEEEAAQKNMALKKIRELESQISELQEDLESERASR 1127
Query: 267 EQLECQLKTEKDEKELYKVHLKNTEIENTKLMSEVQTLKNLDGN--KESVITHFKEEIGR 324
+ E Q + +E E K L++T +++T E+++ + + N K+++ K +
Sbjct: 1128 NKAEKQKRDLGEELEALKTELEDT-LDSTAAQQELRSKREQEVNILKKTLEEEAKTHEAQ 1186
Query: 325 LQLCLAEKENLQRTFLLTTSSKEDTCFLKEQLRKAEEQVQATR----QEVVFLAKELSDA 380
+Q ++ + E T +K L KA++ ++ R EV L + D+
Sbjct: 1187 IQ---EMRQKHSQAVEELAEQLEQTKRVKANLEKAKQTLENERGELANEVKVLLQGKGDS 1243
Query: 381 VNVRDRTMADLHTARL---ENEKVKKQLADAVAEL----------------KLNAMKKD- 420
+ R + A L ++ E E+V+ +LAD V +L K + + KD
Sbjct: 1244 EHKRKKVEAQLQELQVKFNEGERVRTELADKVTKLQVELDNVTGLLSQSDSKSSKLTKDF 1303
Query: 421 -------QDKTDTLEHELRREVEDLKLRLQMAADH---YKEKFKECQ----RLQKQINKL 466
QD + L+ E R+++ L +L+ D ++E+ +E + L+KQI L
Sbjct: 1304 SALESQLQDTQELLQEENRQKL-SLSTKLKQVEDEKNSFREQLEEEEEAKHNLEKQIATL 1362
Query: 467 SDQSANNNNVFTKKTG-----------NQQKVNDASVNTDPATSASTVDVKPSPSAAEAD 515
Q A+ G Q+ + S + +A K +
Sbjct: 1363 HAQVADMKKKMEDSVGCLETAEEVKRKLQKDLEGLSQRHEEKVAAYDKLEKTKTRLQQEL 1422
Query: 516 FDIVTKGQVCEMTKEIADKTEKYNKCKQLLQDEKAKCNKYADELAKMELKWKEQVKIAEN 575
D++ + + + +K K QLL +EK KYA+E + E + +E+ A +
Sbjct: 1423 DDLLV--DLDHQRQSACNLEKKQKKFDQLLAEEKTISAKYAEERDRAEAEAREKETKALS 1480
Query: 576 VKLELAEVQDNYKELKRSLENPAERKMEGQNSQSPQCFKTCSE 618
+ L E + EL+R L +ME S K+ E
Sbjct: 1481 LARALEEAMEQKAELER-LNKQFRTEMEDLMSSKDDVGKSVHE 1522
Score = 56.6 bits (135), Expect = 9e-08
Identities = 110/540 (20%), Positives = 221/540 (40%), Gaps = 94/540 (17%)
Query: 153 KIEKTMKEKEELLKLIAVLEKETAQLREQVG--------------RMERELNHEKERCDQ 198
++E+T + K L K LE E +L +V ++E +L + + ++
Sbjct: 1204 QLEQTKRVKANLEKAKQTLENERGELANEVKVLLQGKGDSEHKRKKVEAQLQELQVKFNE 1263
Query: 199 LQAEQKGLTEVTQSLKMENEEFKKRFSDATSKAHQLEEDIVSV------THKAIEKETEL 252
+ + L + L++E + S + SK+ +L +D ++ T + +++E
Sbjct: 1264 GERVRTELADKVTKLQVELDNVTGLLSQSDSKSSKLTKDFSALESQLQDTQELLQEENRQ 1323
Query: 253 D-SLKDKLKKAQHE----REQLECQLKTEKD-EKELYKVH----------------LKNT 290
SL KLK+ + E REQLE + + + + EK++ +H L+
Sbjct: 1324 KLSLSTKLKQVEDEKNSFREQLEEEEEAKHNLEKQIATLHAQVADMKKKMEDSVGCLETA 1383
Query: 291 EIENTKLMSEVQTLKNLDGNK-------ESVITHFKEEIGRLQLCLAEK-------ENLQ 336
E KL +++ L K E T ++E+ L + L + E Q
Sbjct: 1384 EEVKRKLQKDLEGLSQRHEEKVAAYDKLEKTKTRLQQELDDLLVDLDHQRQSACNLEKKQ 1443
Query: 337 RTF-LLTTSSKEDTCFLKEQLRKAEEQVQATRQEVVFLAKELSDA---------VNVRDR 386
+ F L K + E+ +AE + + + + LA+ L +A +N + R
Sbjct: 1444 KKFDQLLAEEKTISAKYAEERDRAEAEAREKETKALSLARALEEAMEQKAELERLNKQFR 1503
Query: 387 T-MADLHTAR-------LENEKVKKQLADAVAELKLNAMKKDQDKTDTLEHELRREVEDL 438
T M DL +++ E EK K+ L V E+K + + LE EL + ED
Sbjct: 1504 TEMEDLMSSKDDVGKSVHELEKSKRALEQQVEEMK--------TQLEELEDEL-QATEDA 1554
Query: 439 KLRLQMAADHYKEKF-KECQRLQKQINKLSDQSANNNNVFTKKTGNQQKVNDASVNTDPA 497
KLRL++ K +F ++ Q +Q + Q + +++K +V
Sbjct: 1555 KLRLEVNLQAMKAQFERDLQGRDEQSEEKKKQLVRQVREMEAELEDERKQRSMAVAARKK 1614
Query: 498 TSASTVDVKPSPSAAEADFDIVTKGQVCEMTKEIADKTEKYNKCKQLLQDEKAKCNKYAD 557
D++ +A + D K Q+ ++ ++ D + + + ++ A+ +
Sbjct: 1615 LEMDLKDLEAHIDSANKNRDEAIK-QLRKLQAQMKDCMRELDDTRASREEILAQAKENEK 1673
Query: 558 ELAKME---LKWKEQVKIAENVKLELAEVQDNYKEL------KRSLENPAERKMEGQNSQ 608
+L ME ++ +E++ AE K + + +D + K +L +R++E + +Q
Sbjct: 1674 KLKSMEAEMIQLQEELAAAERAKRQAQQERDELADEIANSSGKGALALEEKRRLEARIAQ 1733
Score = 50.4 bits (119), Expect = 6e-06
Identities = 63/311 (20%), Positives = 120/311 (38%), Gaps = 57/311 (18%)
Query: 132 MEDEGNSDMLVVTTKAGL------LELKIEKTMKEKEELLKLIAVLEKE----------T 175
+EDE + V + L LE I+ K ++E +K + L+ + T
Sbjct: 1598 LEDERKQRSMAVAARKKLEMDLKDLEAHIDSANKNRDEAIKQLRKLQAQMKDCMRELDDT 1657
Query: 176 AQLREQV----GRMERELNHEKERCDQLQAEQKGLTEVTQSLKMENEEFKKRFSDATSKA 231
RE++ E++L + QLQ E + + E +E ++++ K
Sbjct: 1658 RASREEILAQAKENEKKLKSMEAEMIQLQEELAAAERAKRQAQQERDELADEIANSSGKG 1717
Query: 232 -------HQLEEDIVSVTHKAIEKETELDSLKDKLKKAQHEREQLECQLKTEKDEKELYK 284
+LE I + + E++ + + D+LKKA + +Q+ L E+ + +
Sbjct: 1718 ALALEEKRRLEARIAQLEEELEEEQGNTELINDRLKKANLQIDQINTDLNLERSHAQKNE 1777
Query: 285 VHLKNTEIENTKLMSEVQTLKNLDGNK-ESVITHFKEEIGRLQLCL----AEKENLQRTF 339
+ E +N +L ++Q ++ +K ++ IT + +I +L+ L E++ +
Sbjct: 1778 NARQQLERQNKELKVKLQEMEGTVKSKYKASITALEAKIAQLEEQLDNETKERQAACKQV 1837
Query: 340 LLTTSSKEDTCF-------------------------LKEQLRKAEEQVQATRQEVVFLA 374
T +D LK QL +AEE+ Q L
Sbjct: 1838 RRTEKKLKDVLLQVDDERRNAEQYKDQADKASTRLKQLKRQLEEAEEEAQRANASRRKLQ 1897
Query: 375 KELSDAVNVRD 385
+EL DA D
Sbjct: 1898 RELEDATETAD 1908
Score = 43.1 bits (100), Expect = 0.001
Identities = 29/131 (22%), Positives = 58/131 (44%), Gaps = 7/131 (5%)
Query: 131 TMEDEGNSDMLVVTTKAGLLELKIEKTMKEKEELLKLIAVLEKETAQLREQVGRMERELN 190
T++ + + + + K LE +++ KE++ K + EK+ + QV R
Sbjct: 1800 TVKSKYKASITALEAKIAQLEEQLDNETKERQAACKQVRRTEKKLKDVLLQVDDERRNAE 1859
Query: 191 HEKERCDQLQAEQKGLTEVTQSLKMENEEFKKRFSDATSKAHQLEEDIVSVTHKAIEKET 250
K++ D+ K LK + EE ++ A + +L+ ++ T A
Sbjct: 1860 QYKDQADKASTRLK-------QLKRQLEEAEEEAQRANASRRKLQRELEDATETADAMNR 1912
Query: 251 ELDSLKDKLKK 261
E+ SLK+KL++
Sbjct: 1913 EVSSLKNKLRR 1923
>gi|98986453 myosin, heavy chain 3, skeletal muscle, embryonic [Homo
sapiens]
Length = 1940
Score = 82.8 bits (203), Expect = 1e-15
Identities = 105/505 (20%), Positives = 220/505 (43%), Gaps = 27/505 (5%)
Query: 119 QFRASSPVEELLTMEDEGNSDMLVVTTKAGLLELKIEKTMKEKEELLKLIAVLEKETAQL 178
+F+ + ++E+ ++ +T K LE + + K+ ++L +A +EKE
Sbjct: 913 KFQLEAKIKEVTERAEDEEEINAELTAKKRKLEDECSELKKDIDDLELTLAKVEKEKHAT 972
Query: 179 REQVGRMERELNHEKERCDQLQAEQKGLTEVTQSL--KMENEEFKKRFSDAT-SKAHQLE 235
+V + EL+ E +L E+K L E Q ++ EE K + T SK Q
Sbjct: 973 ENKVKNLTEELSGLDETIAKLTREKKALQEAHQQALDDLQAEEDKVNSLNKTKSKLEQQV 1032
Query: 236 EDIVSVTHKAIEKETELDSLKDKLKKAQHEREQLECQLKTEKDEKELYKVHLKNTEIENT 295
ED+ S + EK+ +D ++K K + E L E D+++L + LK + E
Sbjct: 1033 EDLESSLEQ--EKKLRVDLERNKRKLEGDLKLAQESILDLENDKQQLDE-RLKKKDFEYC 1089
Query: 296 KLMSEVQTLKNLDGNKESVITHFKEEIGRLQLCLAEKENLQRTFLLTTSSKEDTC-FLKE 354
+L S+V+ + L + I + I L+ E E + T T + D L+E
Sbjct: 1090 QLQSKVEDEQTLGLQFQKKIKELQARIEELE---EEIEAERATRAKTEKQRSDYARELEE 1146
Query: 355 QLRKAEEQVQATRQEVVFLAKELSDAVNVRDRTMADLHTARLENE----KVKKQLADAVA 410
+ EE T ++ K ++ + +R DL A L++E ++K+ AD+VA
Sbjct: 1147 LSERLEEAGGVTSTQIELNKKREAEFLKLR----RDLEEATLQHEAMVAALRKKHADSVA 1202
Query: 411 EL--KLNAMKKDQDKTDTLEHELRREVEDLKLRLQMAADHYKEKFKECQRLQKQINKLSD 468
EL +++ +++ + K + + E + E++DL ++ + K C+ L+ Q+++
Sbjct: 1203 ELGEQIDNLQRVKQKLEKEKSEFKLEIDDLSSSMESVSKSKANLEKICRTLEDQLSE--- 1259
Query: 469 QSANNNNVFTKKTGNQQKVNDASVNTDPATSASTVDVKPSPSAAEADFDIVTKGQVCEMT 528
A N +++ ++ + + T+ + ++ K S + + Q E+
Sbjct: 1260 --ARGKNEEIQRSLSELTTQKSRLQTEAGELSRQLEEKESIVSQLSRSKQAFTQQTEELK 1317
Query: 529 KEIADKTEKYNKCKQLLQDEKAKCNKYADELAKMELKWKEQVKIAENVKLELAEVQDNYK 588
+++ ++ + N LQ + C+ ++ + + E + E+A+ + Y+
Sbjct: 1318 RQLEEENKAKNALAHALQSSRHDCDLLREQYEEEQEGKAELQRALSKANSEVAQWRTKYE 1377
Query: 589 --ELKRSLENPAERKMEGQNSQSPQ 611
++R+ E +K Q Q +
Sbjct: 1378 TDAIQRTEELEEAKKKLAQRLQDSE 1402
Score = 71.6 bits (174), Expect = 3e-12
Identities = 103/582 (17%), Positives = 223/582 (38%), Gaps = 58/582 (9%)
Query: 74 HYVEGSTVNCVLAFQGYYLPNDDGEFYQFCYVTHKGEIRGASTPFQFRASSPVEELLTME 133
H ++ S +C L + Y + Q E+ T ++ A EEL +
Sbjct: 1332 HALQSSRHDCDLLREQYEEEQEGKAELQRALSKANSEVAQWRTKYETDAIQRTEELEEAK 1391
Query: 134 -------DEGNSDMLVVTTKAGLLELKIEKTMKEKEELLKLIAVLEKETAQLREQVGRME 186
+ + V K LE ++ E E+L+ + A L ++ +
Sbjct: 1392 KKLAQRLQDSEEQVEAVNAKCASLEKTKQRLQGEVEDLMVDVERANSLAAALDKKQRNFD 1451
Query: 187 RELNHEKERCDQLQAEQKGLTEVTQSLKMENEEFKKRFSDATSKAH-------QLEEDIV 239
+ L K +C++ QAE + + ++SL E + K + +A + LE++I
Sbjct: 1452 KVLAEWKTKCEESQAELEASLKESRSLSTELFKLKNAYEEALDQLETVKRENKNLEQEIA 1511
Query: 240 SVTHKAIEKETELDSLKDKLKKAQHEREQLECQLKTEKDEKELYKVHLKNTEIENTKLMS 299
+T + E + L+ K+ + E+ ++ L+ + E + + ++E T++ S
Sbjct: 1512 DLTEQIAENGKTIHELEKSRKQIELEKADIQLALEEAEAALEHEEAKILRIQLELTQVKS 1571
Query: 300 EV-QTLKNLDGNKESVITHFKEEIGRLQLCL-AEKENLQRTFLLTTSSKEDTCFLKEQLR 357
E+ + + D E + +++ + +Q L AE + L + D ++ QL
Sbjct: 1572 EIDRKIAEKDEEIEQLKRNYQRTVETMQSALDAEVRSRNEAIRLKKKMEGDLNEIEIQLS 1631
Query: 358 KAEEQVQATRQEVVFLAKELSDA------------------------VNVRDRTMADLHT 393
A Q T + + + +L D N+ + +L
Sbjct: 1632 HANRQAAETLKHLRSVQGQLKDTQLHLDDALRGQEDLKEQLAIVERRANLLQAEVEELRA 1691
Query: 394 ARLENEKVKK----QLADAVAELKL-----NAMKKDQDKTDTLEHELRREVEDLKLRLQM 444
+ E+ +K +L D+ ++L ++ + K +T +L+ EVED +
Sbjct: 1692 TLEQTERARKLAEQELLDSNERVQLLHTQNTSLIHTKKKLETDLMQLQSEVEDASRDARN 1751
Query: 445 AADHYKEKFKECQRLQKQINKLSDQSANNNNVFTKKTGNQQKVNDASVNTDPATSASTVD 504
A + K+ + + +++ K D SA+ + K +Q V D D A +
Sbjct: 1752 AEEKAKKAITDAAMMAEELKKEQDTSAHLERM---KKNLEQTVKDLQHRLDEAEQLALKG 1808
Query: 505 VKPSPSAAEA---DFDIVTKGQVCEMTKEIADKTEKYNKCKQLL---QDEKAKCNKYADE 558
K E + + +G+ + T+ + + + K+L ++++ + D
Sbjct: 1809 GKKQIQKLETRIRELEFELEGEQKKNTESVKGLRKYERRVKELTYQSEEDRKNVLRLQDL 1868
Query: 559 LAKMELKWKEQVKIAENVKLELAEVQDNYKELKRSLENPAER 600
+ K+++K K + AE + +++ + LE ER
Sbjct: 1869 VDKLQVKVKSYKRQAEEADEQANAHLTKFRKAQHELEEAEER 1910
Score = 70.5 bits (171), Expect = 6e-12
Identities = 101/475 (21%), Positives = 203/475 (42%), Gaps = 36/475 (7%)
Query: 153 KIEKTMKEKEELLKLIAVLEKETAQLREQVGRMERELNHEKERCD-------QLQAEQKG 205
++ K+ +++EL + + L +E L+ QV L +ERCD QL+A+ K
Sbjct: 863 ELAKSEAKRKELEEKLVTLVQEKNDLQLQVQAESENLLDAEERCDQLIKAKFQLEAKIKE 922
Query: 206 LTEVTQSLKMENEEFKKRFSDATSKAHQLEEDIVSVTHKAIEKETELDSLKDKLKKAQHE 265
+TE + + N E + + +L++DI + + E E + ++K+K E
Sbjct: 923 VTERAEDEEEINAELTAKKRKLEDECSELKKDIDDLELTLAKVEKEKHATENKVKNLTEE 982
Query: 266 REQL-ECQLKTEKDEKELYKVH---LKNTEIENTKLMSEVQTLKNLDGNKESVITHFKEE 321
L E K +++K L + H L + + E K+ S +T L+ E + + ++E
Sbjct: 983 LSGLDETIAKLTREKKALQEAHQQALDDLQAEEDKVNSLNKTKSKLEQQVEDLESSLEQE 1042
Query: 322 IGRLQLCL-AEKENLQRTFLLTTSS----KEDTCFLKEQLRKAE----------EQVQAT 366
+L++ L K L+ L S + D L E+L+K + E Q
Sbjct: 1043 -KKLRVDLERNKRKLEGDLKLAQESILDLENDKQQLDERLKKKDFEYCQLQSKVEDEQTL 1101
Query: 367 RQEVVFLAKELSDAVNVRDRTMADLHTARLENEKVKKQLADAVAELKLNAMKKDQDKTDT 426
+ KEL + + + R + EK + A + EL + +
Sbjct: 1102 GLQFQKKIKELQARIEELEEEIEAERATRAKTEKQRSDYARELEELSERLEEAGGVTSTQ 1161
Query: 427 LEHELRREVEDLKLRLQMAADHYKEKFKECQRLQKQINKLSDQSANNNNVFTKKTGNQQK 486
+E +RE E LKLR + + + +K + +++ +N+ K +++
Sbjct: 1162 IELNKKREAEFLKLRRDLEEATLQHEAMVAALRKKHADSVAELGEQIDNLQRVKQKLEKE 1221
Query: 487 VNDASVNTDPATSASTVDVKPSPSAAEADFDIVTKGQVCEMTKEIADKTEKYNKCKQLLQ 546
++ + D +S+ S S ++A+ + + + + + E K E+ + L
Sbjct: 1222 KSEFKLEIDDLSSS-----MESVSKSKANLEKICR-TLEDQLSEARGKNEEIQRSLSELT 1275
Query: 547 DEKAKCNKYADELAKMELKWKEQVKIAENVKLELAEVQDNYKELKRSLENPAERK 601
+K++ A EL++ +L+ KE + +++ + + A Q +ELKR LE + K
Sbjct: 1276 TQKSRLQTEAGELSR-QLEEKESI-VSQLSRSKQAFTQQT-EELKRQLEEENKAK 1327
Score = 57.8 bits (138), Expect = 4e-08
Identities = 88/468 (18%), Positives = 207/468 (44%), Gaps = 62/468 (13%)
Query: 212 SLKMENEEFKKRFSDATSKAHQLEEDIVSVTHKAIEKETELDSLKDKLKKAQHEREQL-E 270
++K E ++ K + + +K +LEE +V++ + + + ++ + + L A+ +QL +
Sbjct: 852 TMKEEFQKTKDELAKSEAKRKELEEKLVTLVQEKNDLQLQVQAESENLLDAEERCDQLIK 911
Query: 271 CQLKTEKDEKELYKVHLKNTEIENTKLMSEVQTLKNLDGNKESVITHFKEEIGRLQLCLA 330
+ + E KE+ + ++ E N +L ++ + L E + K++I L+L LA
Sbjct: 912 AKFQLEAKIKEVTE-RAEDEEEINAELTAKKRKL-------EDECSELKKDIDDLELTLA 963
Query: 331 EKE------------------NLQRTFLLTTSSKEDTCFLKEQLRKAEEQVQATRQEVVF 372
+ E L T T K+ L+E ++A + +QA +V
Sbjct: 964 KVEKEKHATENKVKNLTEELSGLDETIAKLTREKK---ALQEAHQQALDDLQAEEDKVNS 1020
Query: 373 LAK---ELSDAVNVRDRTMADLHTARLENEKVKKQLADAVAELKLNAMKKDQDKTDTLEH 429
L K +L V + ++ R++ E+ K++L + + + + + DK E
Sbjct: 1021 LNKTKSKLEQQVEDLESSLEQEKKLRVDLERNKRKLEGDLKLAQESILDLENDKQQLDER 1080
Query: 430 ELRREVEDLKLRLQMAAD-----HYKEKFKECQ-RLQKQINKLSDQSANNNNVFTKKTGN 483
+++ E +L+ ++ + +++K KE Q R+++ ++ + A +++
Sbjct: 1081 LKKKDFEYCQLQSKVEDEQTLGLQFQKKIKELQARIEELEEEIEAERATRAKTEKQRSDY 1140
Query: 484 QQKVNDASVNTDPATSASTVDVKPSPSAAEADF----------DIVTKGQVCEMTK---- 529
+++ + S + A ++ ++ + EA+F + + V + K
Sbjct: 1141 ARELEELSERLEEAGGVTSTQIELN-KKREAEFLKLRRDLEEATLQHEAMVAALRKKHAD 1199
Query: 530 ---EIADKTEKYNKCKQLLQDEKAKCNKYADEL-AKMELKWKEQV---KIAENVKLELAE 582
E+ ++ + + KQ L+ EK++ D+L + ME K + KI ++ +L+E
Sbjct: 1200 SVAELGEQIDNLQRVKQKLEKEKSEFKLEIDDLSSSMESVSKSKANLEKICRTLEDQLSE 1259
Query: 583 VQDNYKELKRSLENPAERKMEGQNSQSPQCFKTCSEQNGYVLTLSNAQ 630
+ +E++RSL +K Q +++ + + E+ V LS ++
Sbjct: 1260 ARGKNEEIQRSLSELTTQKSRLQ-TEAGELSRQLEEKESIVSQLSRSK 1306
Score = 55.5 bits (132), Expect = 2e-07
Identities = 80/366 (21%), Positives = 161/366 (43%), Gaps = 50/366 (13%)
Query: 255 LKDKLKKAQHEREQLECQLKTEKDEKELYKVHLKNTEIENTKLMSEVQTLKNLDGNKESV 314
+K LK A+ E+E + + +K + EL K K E+E KL++ VQ +L
Sbjct: 837 IKPLLKSAETEKEMATMKEEFQKTKDELAKSEAKRKELEE-KLVTLVQEKNDL------- 888
Query: 315 ITHFKEEIGRLQLCLAEKENLQRTFLLTTSSKEDTCFLKEQLRKAEEQVQATRQEVVFLA 374
+LQ+ AE ENL E+ C +QL KA+ Q++A +EV A
Sbjct: 889 ---------QLQV-QAESENL--------LDAEERC---DQLIKAKFQLEAKIKEVTERA 927
Query: 375 ---KELSDAVNVRDRTMADLHTARLENEKVKKQLADAVAELKLNAMKKDQDKTDTLEHEL 431
+E++ + + R + D E ++KK + D EL L ++K++ T E+++
Sbjct: 928 EDEEEINAELTAKKRKLED------ECSELKKDIDD--LELTLAKVEKEKHAT---ENKV 976
Query: 432 RREVEDLKLRLQMAADHYKEKFKECQRLQKQINKLSDQSANNNNVFTKKTGNQQKVNDAS 491
+ E+L + A +EK + Q+ ++ L + N++ K+ +Q+V D
Sbjct: 977 KNLTEELSGLDETIAKLTREKKALQEAHQQALDDLQAEEDKVNSLNKTKSKLEQQVEDLE 1036
Query: 492 VNTDPATSASTVDVKPSPSAAEADFDIV------TKGQVCEMTKEIADKTEKYNKCKQLL 545
+ + VD++ + E D + + ++ + + K +Y + + +
Sbjct: 1037 SSLEQEKKL-RVDLERNKRKLEGDLKLAQESILDLENDKQQLDERLKKKDFEYCQLQSKV 1095
Query: 546 QDEKAKCNKYADELAKMELKWKEQVKIAENVKLELAEVQDNYKELKRSLENPAERKMEGQ 605
+DE+ ++ ++ +++ + +E + E + A+ + + R LE +ER E
Sbjct: 1096 EDEQTLGLQFQKKIKELQARIEELEEEIEAERATRAKTEKQRSDYARELEELSERLEEAG 1155
Query: 606 NSQSPQ 611
S Q
Sbjct: 1156 GVTSTQ 1161
Score = 40.0 bits (92), Expect = 0.008
Identities = 34/161 (21%), Positives = 76/161 (47%), Gaps = 9/161 (5%)
Query: 145 TKAGLLELK--IEKTMKEKEELLKLIAVL-----EKETAQLREQVGRMERELNHEKERCD 197
T A L +K +E+T+K+ + L L +K+ +L ++ +E EL E+++
Sbjct: 1776 TSAHLERMKKNLEQTVKDLQHRLDEAEQLALKGGKKQIQKLETRIRELEFELEGEQKKNT 1835
Query: 198 QLQAEQKGLTEVTQSLKMENEEFKKRFSDATSKAHQLEEDIVSVTHKAIEKETELDSLKD 257
+ + + L ++EE +K +L+ + S +A E + + ++
Sbjct: 1836 ESVKGLRKYERRVKELTYQSEEDRKNVLRLQDLVDKLQVKVKSYKRQAEEADEQANAHLT 1895
Query: 258 KLKKAQHEREQLECQLKTEKDEKELYKVHLKNTEIENTKLM 298
K +KAQHE E E + + + E ++ K+ K + +++++
Sbjct: 1896 KFRKAQHELE--EAEERADIAESQVNKLRAKTRDFTSSRMV 1934
>gi|110624781 myosin, heavy polypeptide 13, skeletal muscle [Homo
sapiens]
Length = 1938
Score = 82.8 bits (203), Expect = 1e-15
Identities = 116/539 (21%), Positives = 219/539 (40%), Gaps = 80/539 (14%)
Query: 128 ELLTMEDEGNSDMLVVTTKAGL-------------LELKIEKTMKEKEELLKLIAVLEKE 174
E L E+E NS++ V K L LEL + K KEK + L +E
Sbjct: 928 ERLEEEEEMNSEL--VAKKRNLEDKCSSLKRDIDDLELTLTKVEKEKHATENKVKNLSEE 985
Query: 175 TAQLREQVGRMERELNHEKER----CDQLQAEQ---KGLTEVTQSLKMENEEF------- 220
L E + ++ +E +E D LQ E+ GL ++ L+ + ++
Sbjct: 986 MTALEENISKLTKEKKSLQEAHQQTLDDLQVEEDKVNGLIKINAKLEQQTDDLEGSLEQE 1045
Query: 221 KKRFSDATSKAHQLEEDIVSVTHKAIEKETELDSLKDKLKKAQHEREQLECQLKTEKDEK 280
KK +D +LE D+ ++ E + +++KLKK + E QL+ ++ E+
Sbjct: 1046 KKLRADLERAKRKLEGDLKMSQESIMDLENDKQQIEEKLKKKEFELSQLQAKIDDEQVHS 1105
Query: 281 ELYKVHLKNTEIENTKLMSEVQTLKNLDGNKESVITHFKEEIGRLQLCLAEKENLQRTFL 340
++ +K + +L E++ L E + E+ + L E
Sbjct: 1106 LQFQKKIKELQARIEELEEEIEAEHTLRAKIEKQRSDLARELEEISERLEEASG------ 1159
Query: 341 LTTSSKEDTCFLKEQLRKAEEQVQATRQEVVFLAKELSDAVNVRDRTMADLHTARLENEK 400
TS++ E +K E + Q R ++L +A + T A L
Sbjct: 1160 -ATSAQ------IEMNKKREAEFQKMR-------RDLEEATLQHEATAATL--------- 1196
Query: 401 VKKQLADAVAEL--KLNAMKKDQDKTDTLEHELRREVEDLKLRLQMAADHYKEKFKECQR 458
+K+ AD+VAEL +++ +++ + K + + EL+ E++D+ ++ + + C+
Sbjct: 1197 -RKKQADSVAELGEQIDNLQRVKQKLEKEKSELKMEIDDMASNIEALSKSKSNIERTCRT 1255
Query: 459 LQKQINKLSDQSANNNNVFTKKTGNQQKVNDASVNTDPATSASTVDVKPSPSAAEADFDI 518
++ Q +++ + + N QK A + T + V+ K S +
Sbjct: 1256 VEDQFSEIKAKDEQQTQLIHDL--NMQK---ARLQTQNGELSHRVEEKESLISQLTKSKQ 1310
Query: 519 VTKGQVCEMTKEIADKTEKYNKCKQLLQDEKAKCN----KYADEL-AKMELK---WKEQV 570
Q+ E+ +++ ++T+ N LQ + C+ +Y +E AK EL+ K
Sbjct: 1311 ALTQQLEELKRQMEEETKAKNAMAHALQSSRHDCDLLREQYEEEQEAKAELQRALSKANS 1370
Query: 571 KIAE-NVKLELAEVQ--DNYKELKRSLE---NPAERKMEGQNSQSPQCFKTCSEQNGYV 623
++A+ K E +Q + +E K+ L AE E NS+ KT G V
Sbjct: 1371 EVAQWRTKYETDAIQRTEELEEAKKKLAQRLQEAEENTETANSKCASLEKTKQRLQGEV 1429
Score = 70.1 bits (170), Expect = 8e-12
Identities = 123/537 (22%), Positives = 231/537 (43%), Gaps = 58/537 (10%)
Query: 110 EIRGASTPFQFRASSPVEELLTMEDEGNSDMLVVTTKAGLLELKIEKTMKEKEELLKLI- 168
E + A Q S E+ + +D + T + + K+ + ++E EE +
Sbjct: 1353 EEQEAKAELQRALSKANSEVAQWRTKYETDAIQRTEELEEAKKKLAQRLQEAEENTETAN 1412
Query: 169 ---AVLEKETAQLREQVGRMERELNHEKERCDQLQAEQKGLTEVTQSLKMENEEFKKRFS 225
A LEK +L+ +V + R+L C L +Q+ +V K + +E +
Sbjct: 1413 SKCASLEKTKQRLQGEVEDLMRDLERSHTACATLDKKQRNFDKVLAEWKQKLDESQAELE 1472
Query: 226 DATSKAHQLEEDIVSVTHKAIEKETELDSLKDKLKKAQHEREQLECQL-KTEKDEKELYK 284
A ++ L ++ + + E +L++L+ + K Q E L Q+ +T K+ +E K
Sbjct: 1473 AAQKESRSLSTELFKMRNAYEEVVDQLETLRRENKNLQEEISDLTEQIAETGKNLQEAEK 1532
Query: 285 VHLKNTEIENTKLMSEVQTLKNLDGNKESVITHFKEEIGRLQLCLAE-KENLQRTFLLTT 343
K E E + L L+ ++G+ E H + +I R+QL L++ K L R +
Sbjct: 1533 TK-KLVEQEKSDLQ---VALEEVEGSLE----HEESKILRVQLELSQVKSELDRKVI--- 1581
Query: 344 SSKEDTCFLKEQLRKAEEQVQA-------TRQEVVFLAKELSDAVNVRDRTMADLHTARL 396
E+ LK ++A E +Q+ +R + + L K++ +N + + +
Sbjct: 1582 EKDEEIEQLKRNSQRAAEALQSVLDAEIRSRNDALRLKKKMEGDLNEMEIQLGHSNRQMA 1641
Query: 397 ENEK----VKKQLADAVAELKLNAMKKDQDKTDTLEHELRR------EVEDLKLRLQMAA 446
E +K V+ QL D+ L +A++ ++D + L RR E+E++K+ L
Sbjct: 1642 ETQKHLRTVQGQLKDSQLHLD-DALRSNEDLKEQLAIVERRNGLLLEELEEMKVAL---- 1696
Query: 447 DHYKEKFKECQRLQKQINKLSDQSANNNNVFTKKTG--NQQKVNDASVNTDPATSASTVD 504
E+ + +RL +Q +L D S + ++ T N +K +A + A ++
Sbjct: 1697 ----EQTERTRRLSEQ--ELLDASDRVQLLHSQNTSLINTKKKLEADIAQCQAEVENS-- 1748
Query: 505 VKPSPSAAE-ADFDIVTKGQVCEMTKEIADKTEKYNKCKQLLQDEKAKCNKYADELAKME 563
++ S +A E A I + E K+ D + + K+ L+ DE ++
Sbjct: 1749 IQESRNAEEKAKKAITDAAMMAEELKKEQDTSAHLERMKKNLEQTVKDLQHRLDEAEQLA 1808
Query: 564 LK-WKEQVKIAENVKLELAEVQDNYKELKRSLE-----NPAERKMEGQNSQSPQCFK 614
LK K+Q++ EN EL D E KR E + ERK++ Q+ + K
Sbjct: 1809 LKGGKKQIQKLENRVRELENELD--VEQKRGAEALKGAHKYERKVKEMTYQAEEDHK 1863
Score = 67.4 bits (163), Expect = 5e-11
Identities = 103/501 (20%), Positives = 200/501 (39%), Gaps = 64/501 (12%)
Query: 126 VEELLTMEDEGNSDMLVVTTKAGLLELKIEKTMKEKEELLKLIAVLEKETAQLREQVGRM 185
+EE L ++ S + + L+ +K +KE + ++ + + LR ++ +
Sbjct: 1080 IEEKLKKKEFELSQLQAKIDDEQVHSLQFQKKIKELQARIEELEEEIEAEHTLRAKIEKQ 1139
Query: 186 ERELNHEKERCDQLQAEQKGLTEVTQSLKMENE-EFKKRFSDATSKAHQLEEDIVSVTHK 244
+L E E + E G T + + E EF+K D Q E ++ K
Sbjct: 1140 RSDLARELEEISERLEEASGATSAQIEMNKKREAEFQKMRRDLEEATLQHEATAATLRKK 1199
Query: 245 AIEKETELDSLKDKLKKAQHEREQLECQLKTEKDE--KELYKVHLKNTEIENT------- 295
+ EL D L++ + + E+ + +LK E D+ + + + IE T
Sbjct: 1200 QADSVAELGEQIDNLQRVKQKLEKEKSELKMEIDDMASNIEALSKSKSNIERTCRTVEDQ 1259
Query: 296 ----KLMSEVQTLKNLDGNKESVITHFKEEIGRLQLCLAEKENLQRTFLLTTSSKEDTCF 351
K E QT D N + + + G L + EKE+L LT S + T
Sbjct: 1260 FSEIKAKDEQQTQLIHDLNMQK--ARLQTQNGELSHRVEEKESL--ISQLTKSKQALTQQ 1315
Query: 352 LKEQLRKAEEQVQATRQEVVFLAKELSDAVNVRDRTMADLHTARLENEKVKKQLADAVAE 411
L+E R+ EE+ +A L D +R++ E ++ K +L A+++
Sbjct: 1316 LEELKRQMEEETKAKNAMAHALQSSRHDCDLLREQYE--------EEQEAKAELQRALSK 1367
Query: 412 LKLN-AMKKDQDKTDTLE--HELRREVEDLKLRLQMAADHYKEKFKECQRLQKQINKLSD 468
A + + +TD ++ EL + L RLQ A ++ + +C L+K +L
Sbjct: 1368 ANSEVAQWRTKYETDAIQRTEELEEAKKKLAQRLQEAEENTETANSKCASLEKTKQRL-- 1425
Query: 469 QSANNNNVFTKKTGNQQKVNDASVNTDPA-TSASTVDVKPSPSAAEADFDIVTKGQVCEM 527
Q +V D + + + T+ +T+D K + +FD
Sbjct: 1426 ---------------QGEVEDLMRDLERSHTACATLDKK------QRNFD---------- 1454
Query: 528 TKEIADKTEKYNKCKQLLQDEKAKCNKYADELAKMELKWKEQVKIAENVKLELAEVQDNY 587
K +A+ +K ++ + L+ + + + EL KM ++E V E ++ E +Q+
Sbjct: 1455 -KVLAEWKQKLDESQAELEAAQKESRSLSTELFKMRNAYEEVVDQLETLRRENKNLQEEI 1513
Query: 588 KELKRSLENPAERKMEGQNSQ 608
+L + + E + ++
Sbjct: 1514 SDLTEQIAETGKNLQEAEKTK 1534
Score = 53.5 bits (127), Expect = 7e-07
Identities = 79/402 (19%), Positives = 164/402 (40%), Gaps = 63/402 (15%)
Query: 255 LKDKLKKAQHEREQLECQLKTEKDEKELYKVHLKNTEIE-------------NTKLMSEV 301
+K LK A+ E+E + E+ ++EL + + E+E ++ SE
Sbjct: 840 IKPLLKSAEAEKEMATMKEDFERTKEELARSEARRKELEEKMVSLLQEKNDLQLQVQSET 899
Query: 302 QTLKNLDGNKESVITH---FKEEIGRLQLCLAEKENLQRTFLLTTSSKEDTCF------- 351
+ L + + E +I + ++ L L E+E + + + ED C
Sbjct: 900 ENLMDAEERCEGLIKSKILLEAKVKELTERLEEEEEMNSELVAKKRNLEDKCSSLKRDID 959
Query: 352 -LKEQLRKAEEQVQATRQEVVFLAKELS------DAVNVRDRTMADLHTARLENEKVKKQ 404
L+ L K E++ AT +V L++E++ + +++ + H L++ +V++
Sbjct: 960 DLELTLTKVEKEKHATENKVKNLSEEMTALEENISKLTKEKKSLQEAHQQTLDDLQVEED 1019
Query: 405 LADAVAELKLNAMKKDQDKTDTLEHE--LRREVE--------DLKLRLQMAADHYKEKFK 454
+ + ++ ++ D +LE E LR ++E DLK+ + D +K +
Sbjct: 1020 KVNGLIKINAKLEQQTDDLEGSLEQEKKLRADLERAKRKLEGDLKMSQESIMDLENDKQQ 1079
Query: 455 ECQRLQKQINKLSDQSANNNNVFTKKTGNQQKVNDASVNTDPATSASTVDVKPSPSAAEA 514
++L+K+ +LS A ++ Q+K+ + + ++ AE
Sbjct: 1080 IEEKLKKKEFELSQLQAKIDDEQVHSLQFQKKIKELQ---------ARIEELEEEIEAEH 1130
Query: 515 DFDIVTKGQVCEMTKEIADKTEKYNKCKQLLQDEKAKCNKYADELAKMELKWKE------ 568
+ Q ++ +E+ + +E+ + + K E KM +E
Sbjct: 1131 TLRAKIEKQRSDLARELEEISERLEEASGATSAQIEMNKKREAEFQKMRRDLEEATLQHE 1190
Query: 569 ------QVKIAENVKLELAEVQDNYKELKRSLE-NPAERKME 603
+ K A++V EL E DN + +K+ LE +E KME
Sbjct: 1191 ATAATLRKKQADSV-AELGEQIDNLQRVKQKLEKEKSELKME 1231
Score = 40.8 bits (94), Expect = 0.005
Identities = 55/242 (22%), Positives = 102/242 (42%), Gaps = 42/242 (17%)
Query: 400 KVKKQLADAVAELKLNAMKKDQDKT--DTLEHELRR------------EVEDLKLRLQMA 445
K+K L A AE ++ MK+D ++T + E RR E DL+L++Q
Sbjct: 839 KIKPLLKSAEAEKEMATMKEDFERTKEELARSEARRKELEEKMVSLLQEKNDLQLQVQSE 898
Query: 446 ADHYKEKFKECQRLQKQ-----------INKLSDQSANNNNVFTKKTGNQQKVNDASVNT 494
++ + + C+ L K +L ++ N+ + KK + K + +
Sbjct: 899 TENLMDAEERCEGLIKSKILLEAKVKELTERLEEEEEMNSELVAKKRNLEDKCSSLKRDI 958
Query: 495 DPATSASTVDVKPSPSAAEADFDIVTKGQVCEMTKEIADKTEKYNKCKQLLQDEKAKCNK 554
D D++ + + E + T+ +V +++E+ E +K + + + +
Sbjct: 959 D--------DLELTLTKVEKE-KHATENKVKNLSEEMTALEENISKLTKEKKSLQEAHQQ 1009
Query: 555 YADELAKMELKWKEQVKIAENVKLE-----LAEVQDNYKELKRSLENPAERKMEGQNSQS 609
D+L E K +KI N KLE L + K+L+ LE A+RK+EG S
Sbjct: 1010 TLDDLQVEEDKVNGLIKI--NAKLEQQTDDLEGSLEQEKKLRADLER-AKRKLEGDLKMS 1066
Query: 610 PQ 611
+
Sbjct: 1067 QE 1068
Score = 35.8 bits (81), Expect = 0.16
Identities = 30/140 (21%), Positives = 64/140 (45%), Gaps = 18/140 (12%)
Query: 155 EKTMKEKEELLKLIAVLEKET------AQLREQVGRMERELNHEKERCDQL-----QAEQ 203
EK K + + L+KE ++++ + + ++L H + +QL + +
Sbjct: 1757 EKAKKAITDAAMMAEELKKEQDTSAHLERMKKNLEQTVKDLQHRLDEAEQLALKGGKKQI 1816
Query: 204 KGLTEVTQSLKMENEEFKKRFSDATSKAHQLEEDIVSVTHKAIEKETEL-------DSLK 256
+ L + L+ E + +KR ++A AH+ E + +T++A E + D L+
Sbjct: 1817 QKLENRVRELENELDVEQKRGAEALKGAHKYERKVKEMTYQAEEDHKNILRLQDLVDKLQ 1876
Query: 257 DKLKKAQHEREQLECQLKTE 276
K+K + + E+ E Q T+
Sbjct: 1877 AKVKSYKRQAEEAEEQANTQ 1896
>gi|56961680 coiled-coil domain containing 147 [Homo sapiens]
Length = 872
Score = 82.0 bits (201), Expect = 2e-15
Identities = 102/470 (21%), Positives = 195/470 (41%), Gaps = 51/470 (10%)
Query: 149 LLELKIEKTMKEKEELLKLIAVLEKETAQLREQVGRMERELNHEKERCDQLQAEQKGLTE 208
LL K E T KE+++LL + L + AQ EQ ER + Q Q E
Sbjct: 151 LLRFKEEVT-KERDQLLSEVVKLRESLAQTTEQQQETERSKEEAEHAISQFQQE------ 203
Query: 209 VTQSLKMENEEFKKRFSDATSKAHQLEEDIVSVTHKAIEKETELDSLKDKLKKAQHEREQ 268
+ Q + EF+K+ +LE+++ + ++TE+ +L+ ++K++ E ++
Sbjct: 204 IQQRQNEASREFRKK--------EKLEKELKQIQADMDSRQTEIKALQQYVQKSKEELQK 255
Query: 269 LECQLKTEKDEKELYKVHLKNTEIENTKLMSE-------VQTLKNLDGNKESVITHFKEE 321
LE QLK +K E L+ ++ N KL E + L + K + +EE
Sbjct: 256 LEQQLKEQKILNERAAKELEQFQMRNAKLQQENEQHSLVCEQLSQENQQKALELKAKEEE 315
Query: 322 IGRLQLCLAEKENLQRTFLLTTSSKEDTCFLKEQLRKAEEQVQATRQEVVFLAKELSDAV 381
+ +++L + + ++ ED Q + E+ + + ++V L +E+ +
Sbjct: 316 VHQMRLDIGKLNKIREQIHKKLHHTED------QKAEVEQHKETLKNQIVGLEREVEASK 369
Query: 382 NVRDRTMADLHTARLENEKVKKQLADAVAELKLNAMKKDQDKTDTLEHELRREVEDLKLR 441
+ + E + + K + AV NA +K D L + E K
Sbjct: 370 KQAELDRKAMDELLRERDILNKNMLKAV-----NATQKQTD--------LVKLHEQAKRN 416
Query: 442 LQMAADHYKEKFKECQRLQKQINKLSDQSANNNNVFTKK---TGNQQKVNDASV-NTDPA 497
L+ +YK++ ++ +++ + K D+ N + T+K KV + + +
Sbjct: 417 LEGEIQNYKDEAQKQRKIIFHLEKERDRYINQASDLTQKVLMNMEDIKVRETQIFDYRKK 476
Query: 498 TSASTVDVKPSPSAAEA---DFDIVTKGQVCEMTKEIADKTEKYNKCKQLLQDEKAKCNK 554
+ S + +K + EA D ++ +K V E EI D K + + K +
Sbjct: 477 IAESEIKLKQQQNLYEAVRSDRNLYSKNLV-EAQDEITDMKRKLKIMIHQVDELKEDISA 535
Query: 555 YADELAKMELKWKEQVKIAENVKLELAEVQDNYKELKRSLE--NPAERKM 602
L K+ L+ + K E +K EL +++ E K +E ERK+
Sbjct: 536 KESALVKLHLEQQRIEKEKETLKAELQKLRQQALETKHFIEKQEAEERKL 585
Score = 58.2 bits (139), Expect = 3e-08
Identities = 98/474 (20%), Positives = 191/474 (40%), Gaps = 61/474 (12%)
Query: 153 KIEKTMKEKEELLKLIAVLEKETAQLREQVGRMERELNHEKERCDQLQAEQKGLTEVTQS 212
K+ +K ++ IA L+KE + + V + KE L+ E LT++ +
Sbjct: 77 KVATALKLSQDDQTTIASLKKEIEKAWKMVDSAYDKEQKAKETILALKEEIVNLTKLVEQ 136
Query: 213 ---LKMEN-----------EEFKKRFSDATSKAHQLEEDIVSVTHKAIEKETELDSLKDK 258
L M+ EE K S+ +L E + T + E E + +
Sbjct: 137 GSGLSMDQHSNIRDLLRFKEEVTKERDQLLSEVVKLRESLAQTTEQQQETERSKEEAEHA 196
Query: 259 LKKAQHEREQLECQLKTEKDEKELYKVHLKNTEIENTKLMSEVQTLKNLDGNKESVITHF 318
+ + Q E +Q + + E +KE + LK + + +E++ L + +
Sbjct: 197 ISQFQQEIQQRQNEASREFRKKEKLEKELKQIQADMDSRQTEIKAL-------QQYVQKS 249
Query: 319 KEEIGRLQLCLAEKENLQRTFLLTTSSKEDTCFLKEQLRKAEEQVQATRQEVVF--LAKE 376
KEE+ +L+ L E++ L ++KE F Q+R A+ Q + + +V L++E
Sbjct: 250 KEELQKLEQQLKEQKILNER-----AAKELEQF---QMRNAKLQQENEQHSLVCEQLSQE 301
Query: 377 LSDAVNVRDRTMADLHTARLEN---EKVKKQLADAVAELKLNAMKKDQDKTDTLEHE--- 430
++H RL+ K+++Q+ + + + +Q K +TL+++
Sbjct: 302 NQQKALELKAKEEEVHQMRLDIGKLNKIREQIHKKLHHTEDQKAEVEQHK-ETLKNQIVG 360
Query: 431 LRREVEDLKLRLQMAADHYKEKFKECQRLQKQINKLSDQSANNNNVFTKKTGNQQKVNDA 490
L REVE K + ++ E +E L K N L +A K Q K N
Sbjct: 361 LEREVEASKKQAELDRKAMDELLRERDILNK--NMLKAVNATQKQTDLVKLHEQAKRNLE 418
Query: 491 SVNTDPATSASTVDVKPSPSAAEADFDIV--TKGQVCEMTKEIADKTEKYNKCKQLLQDE 548
+++ A+ I+ + + + +D T+K + ++
Sbjct: 419 G------------EIQNYKDEAQKQRKIIFHLEKERDRYINQASDLTQKVLMNMEDIKVR 466
Query: 549 KAKCNKYADELAKMELKWKEQVKIAENVKLE-------LAEVQDNYKELKRSLE 595
+ + Y ++A+ E+K K+Q + E V+ + L E QD ++KR L+
Sbjct: 467 ETQIFDYRKKIAESEIKLKQQQNLYEAVRSDRNLYSKNLVEAQDEITDMKRKLK 520
Score = 49.7 bits (117), Expect = 1e-05
Identities = 96/453 (21%), Positives = 191/453 (42%), Gaps = 53/453 (11%)
Query: 151 ELKIEKTMKEKEELLKLIAVLEKET--AQLREQVGR-MERELNHEKERCDQLQAEQKGLT 207
EL E+ + K +LK + +K+T +L EQ R +E E+ + K D+ Q ++K
Sbjct: 381 ELLRERDILNKN-MLKAVNATQKQTDLVKLHEQAKRNLEGEIQNYK---DEAQKQRK--- 433
Query: 208 EVTQSLKMENEEFKKRFSDATSKAHQLEEDIVSVTHKAIEKETELDSLKDKLKKAQHERE 267
+ L+ E + + + SD T K EDI +ET++ + K+ +++ + +
Sbjct: 434 -IIFHLEKERDRYINQASDLTQKVLMNMEDIKV-------RETQIFDYRKKIAESEIKLK 485
Query: 268 QLECQLKTEKDEKELYKVHLKNTEIENTK-------LMSEVQTLKNLDGNKESVITHFKE 320
Q + + + ++ LY +L + E T ++ +V LK KES +
Sbjct: 486 QQQNLYEAVRSDRNLYSKNLVEAQDEITDMKRKLKIMIHQVDELKEDISAKESALVKLHL 545
Query: 321 EIGRLQLCLAEKENLQRTFLLTTSSKEDTCFLKEQLRKAEEQVQATRQEVVFLAKELSDA 380
E R++ EKE L K + L++Q + + ++ E L + +++A
Sbjct: 546 EQQRIE---KEKETL----------KAELQKLRQQALETKHFIEKQEAEERKLLRIIAEA 592
Query: 381 VNVRDRTMADLHTARLENEKVKKQLADAVAELKL--NAMKKDQDKTDTLEHELRREVEDL 438
R R +L E + + QL EL L +K Q + E + + +ED+
Sbjct: 593 DGERLRQKKELDQVISERDILGSQLVRRNDELALLYEKIKIQQSVLNKGESQYNQRLEDM 652
Query: 439 KLRLQMAADHYKEKFKECQRLQKQINKLSDQSANNNNVFTKKTGNQQKVNDASVNTDPAT 498
++ L++ + + R + +L + + K+ + + + N
Sbjct: 653 RI-LRLEIKKLRREKGILARSMANVEELRQEFFHMQRELLKERTRCRALEEELENPLNVH 711
Query: 499 SASTVDVKPSPSAAEADFDIVTKGQVCEMTKEIADKTEKYNKCKQLLQDEKAKCNKYADE 558
++ P+A ++++ K + + K + KTE+ + K+LL EK K Y +
Sbjct: 712 RWRKLEAS-DPNA----YELIQK--IHTLQKRLISKTEEVVE-KELLLQEKEKL--YME- 760
Query: 559 LAKMELKWKEQVKIAENVKLELAEVQDNYKELK 591
K L + + AE +KL + D ++LK
Sbjct: 761 -LKHVLARQPGPEAAEQLKLYRRTLHDKKQQLK 792
Score = 44.7 bits (104), Expect = 3e-04
Identities = 73/408 (17%), Positives = 172/408 (42%), Gaps = 38/408 (9%)
Query: 129 LLTMEDEGNSDMLVVTTKAGLLELKIEKTMKEKEELLKLIA----VLEKETAQLREQVGR 184
L+ MED + + + + E +I+ +K+++ L + + + K + ++++
Sbjct: 457 LMNMEDIKVRETQIFDYRKKIAESEIK--LKQQQNLYEAVRSDRNLYSKNLVEAQDEITD 514
Query: 185 MERELNHEKERCDQLQAEQKGLTEVTQSLKMENEEFKKRFSDATSKAHQLEEDIVSVTHK 244
M+R+L + D+L+ + L +E + +K ++ +L + + H
Sbjct: 515 MKRKLKIMIHQVDELKEDISAKESALVKLHLEQQRIEKEKETLKAELQKLRQQALETKHF 574
Query: 245 AIEKETELDSLKDKLKKAQHEREQLECQLKTEKDEKELYKVHLKNTEIENTKLMSEVQTL 304
++E E L + +A ER + + +L E+++ L E L +++
Sbjct: 575 IEKQEAEERKLLRIIAEADGERLRQKKELDQVISERDILGSQLVRRNDELALLYEKIKIQ 634
Query: 305 KNLDGNKESVITHFKEEIGRLQLCLAEKENLQRTFLLTTSSKEDTCFLKEQLRKAEEQVQ 364
+++ ES + + + +++ E + L+R + S + L+++ + ++
Sbjct: 635 QSVLNKGES---QYNQRLEDMRILRLEIKKLRREKGILARSMANVEELRQEFFHMQRELL 691
Query: 365 ATRQEVVFLAKELSDAVNV---RDRTMADLHTARL--ENEKVKKQL---ADAVAELKLNA 416
R L +EL + +NV R +D + L + ++K+L + V E +L
Sbjct: 692 KERTRCRALEEELENPLNVHRWRKLEASDPNAYELIQKIHTLQKRLISKTEEVVEKELLL 751
Query: 417 MKKDQDKTDTLEHEL---------------RREVEDLKLRLQMAADHYKEKFKECQRLQK 461
+K++ + L+H L RR + D K +L++ + + + +
Sbjct: 752 QEKEKLYME-LKHVLARQPGPEAAEQLKLYRRTLHDKKQQLKVLSSELNMYEVQSKEYKY 810
Query: 462 QINKLSDQSANNNNVFTKKTGNQQKVNDASVNTDPATSAST-VDVKPS 508
++ KL+++ N KK Q++ N D A +T + VKP+
Sbjct: 811 EVEKLTNELQN----LKKKYLAQKRKEQLQKNKDTAPMDNTFLMVKPN 854
Score = 33.9 bits (76), Expect = 0.60
Identities = 73/367 (19%), Positives = 136/367 (37%), Gaps = 91/367 (24%)
Query: 229 SKAHQLEEDIVSVTHKAIEKETELDSLKDKLKKAQHEREQLECQLKTEKDEKELYKVHLK 288
S ++E D V H EL K L+K + E E+L +K D ++ +
Sbjct: 14 SAFEEMERDFQGVLH-------ELSGDKS-LEKFRIEYERLHAVMKKSYDNEKRLMAKCR 65
Query: 289 NTEIENTKLMSEVQTLKNLDGNKESVITHFKEEIGRLQLCLAEKENLQRTFLLTTSSKED 348
E ++V T L + ++ I K+EI + + D
Sbjct: 66 ELNAEIVVNSAKVATALKLSQDDQTTIASLKKEIEKAWKMV------------------D 107
Query: 349 TCFLKEQLRKAEEQVQATRQEVVFLAKELSDAVNVRDRTMADLHTARLENEKVKKQLADA 408
+ + KEQ KA+E + A ++E+V L K + + +++ E+V K+
Sbjct: 108 SAYDKEQ--KAKETILALKEEIVNLTKLVEQGSGLSMDQHSNIRDLLRFKEEVTKERDQL 165
Query: 409 VAELKLNAMKKDQDKTDTLEHELRREVEDLKLRLQMAADHYKEKFKECQRLQKQINKLSD 468
++E+ +K + T E + E R + A+H +F+ Q +Q++ N+ S
Sbjct: 166 LSEV----VKLRESLAQTTEQQQETE------RSKEEAEHAISQFQ--QEIQQRQNEASR 213
Query: 469 QSANNNNVFTKKTGNQQKVNDASVNTDPATSASTVDVKPSPSAAEADFDIVTKGQVCEMT 528
+ F KK ++++ +AD D
Sbjct: 214 E-------FRKKEKLEKELKQI----------------------QADMD----------- 233
Query: 529 KEIADKTEKYNKCKQLLQDEKAKCNKYADELAKMELKWKEQVKIAENVKLELAEVQDNYK 588
+ + +Q +Q K +EL K+E + KEQ + E EL + Q
Sbjct: 234 ----SRQTEIKALQQYVQKSK-------EELQKLEQQLKEQKILNERAAKELEQFQMRNA 282
Query: 589 ELKRSLE 595
+L++ E
Sbjct: 283 KLQQENE 289
>gi|153945790 myosin, heavy chain 8, skeletal muscle, perinatal [Homo
sapiens]
Length = 1937
Score = 81.3 bits (199), Expect = 3e-15
Identities = 106/507 (20%), Positives = 225/507 (44%), Gaps = 54/507 (10%)
Query: 126 VEELLTMEDEGNSDMLVVTTKAGLLELKIEKTMKEKEELLKLIAVLEKETAQLREQVGRM 185
V E E+E N+++ T K LE + + K+ ++L +A +EKE +V +
Sbjct: 925 VTERAEEEEEINAEL---TAKKRKLEDECSELKKDIDDLELTLAKVEKEKHATENKVKNL 981
Query: 186 ERELNHEKERCDQLQAEQKGLTEVTQSL--KMENEEFKKR-FSDATSKAHQLEEDIVSVT 242
E+ E +L E+K L E Q ++ EE K + A +K Q +D+
Sbjct: 982 TEEMAGLDETIAKLSKEKKALQETHQQTLDDLQAEEDKVNILTKAKTKLEQQVDDLEGSL 1041
Query: 243 HKAIEKETELDSLKDKLKKAQHEREQLECQLKTEKDEKELYKVHLKNTEIENTKLMSEVQ 302
+ EK+ +D + K K + E + E D+++L + L+ E E + L+S+++
Sbjct: 1042 EQ--EKKLRMDLERAKRKLEGDLKLAQESTMDMENDKQQLDE-KLEKKEFEISNLISKIE 1098
Query: 303 TLKNLDGNKESVITHFKEEIGRLQLCLAE-KENLQRTFLLTTSSKEDTCFLKEQLRKAEE 361
++++V +++I LQ + E E ++ +++ L +L + E
Sbjct: 1099 -------DEQAVEIQLQKKIKELQARIEELGEEIEAERASRAKAEKQRSDLSRELEEISE 1151
Query: 362 QVQ----ATRQEVVFLAKELSDAVNVRDRTMADLHTARLENE----KVKKQLADAVAEL- 412
+++ AT +V K ++ +R DL A L++E ++K+ AD++AEL
Sbjct: 1152 RLEEAGGATSAQVELNKKREAEFQKLR----RDLEEATLQHEAMVAALRKKHADSMAELG 1207
Query: 413 -KLNAMKKDQDKTDTLEHELRREVEDLKLRLQMAADHYKEKFKECQRLQKQINKLSDQSA 471
+++ +++ + K + + EL+ E +DL + + K C+ L+ Q+++L
Sbjct: 1208 EQIDNLQRVKQKLEKEKSELKMETDDLSSNAEAISKAKGNLEKMCRSLEDQVSELK---- 1263
Query: 472 NNNNVFTKKTGNQQKVND-----ASVNTDPATSASTVDVKPSPSAAEADFDIVTKGQVCE 526
TK+ Q+ +ND A + T+ + +D K + + + + Q+ E
Sbjct: 1264 ------TKEEEQQRLINDLTAQRARLQTEAGEYSRQLDEKDALVSQLSRSKQASTQQIEE 1317
Query: 527 MTKEIADKTEKYNKCKQLLQDEKAKCNKYADELAKMELKWKEQVKIAENVKLELAEVQDN 586
+ ++ ++T+ N LQ + C+ ++ + + E + E+A+ +
Sbjct: 1318 LKHQLEEETKAKNALAHALQSSRHDCDLLREQYEEEQEGKAELQRALSKANSEVAQWRTK 1377
Query: 587 Y--------KELKRSLENPAERKMEGQ 605
Y +EL+ + + A+R E +
Sbjct: 1378 YETDAIQRTEELEEAKKKLAQRLQEAE 1404
Score = 76.3 bits (186), Expect = 1e-13
Identities = 104/538 (19%), Positives = 230/538 (42%), Gaps = 46/538 (8%)
Query: 150 LELKIEKTMKEKEELLKLIAVLEKETAQLREQVGRMERELNHEKERCDQLQAEQKGLTEV 209
LE ++ + ++EE +LI L + A+L+ + G R+L+ + QL ++ T+
Sbjct: 1255 LEDQVSELKTKEEEQQRLINDLTAQRARLQTEAGEYSRQLDEKDALVSQLSRSKQASTQQ 1314
Query: 210 TQSLKMENEEFKKRFSDATSKAHQLEEDIVSVTHKAIEKETE-LDSLKDKLKKAQHEREQ 268
+ LK + EE + + +A + A Q + + E+E E L+ L KA E Q
Sbjct: 1315 IEELKHQLEE-ETKAKNALAHALQSSRHDCDLLREQYEEEQEGKAELQRALSKANSEVAQ 1373
Query: 269 LECQLKTE----KDEKELYKVHL--------KNTEIENTKLMSEVQTLKNLDGNKESVIT 316
+ +T+ +E E K L ++ E N K S +T + L E ++
Sbjct: 1374 WRTKYETDAIQRTEELEEAKKKLAQRLQEAEEHVEAVNAKCASLEKTKQRLQNEVEDLML 1433
Query: 317 HFKEEIGRLQLCLAEKENLQRTFLLTTSSKEDTCFLKEQLRKAEEQVQATRQEVVFLAKE 376
++ R A + QR F S K++ + + +++A+++E L+ E
Sbjct: 1434 ----DVERSNAACAALDKKQRNFDKVLSE------WKQKYEETQAELEASQKESRSLSTE 1483
Query: 377 LSDAVNVRDRTMADLHTARLENEKVKKQLADAVAELKLNAMKKDQDKTDTLEHELRREVE 436
L NV + ++ L T R EN+ ++++++D ++ K + + ++ ++ +E
Sbjct: 1484 LFKVKNVYEESLDQLETLRRENKNLQQEISDLTEQIAEGG--KQIHELEKIKKQVEQEKC 1541
Query: 437 DLKLRLQMAADHYKEKFKECQRLQKQINKLSDQ----SANNNNVFTKKTGNQQKVNDASV 492
+++ L+ A + + + R+Q ++N++ + A + + N +V +
Sbjct: 1542 EIQAALEEAEASLEHEEGKILRIQLELNQVKSEVDRKIAEKDEEIDQLKRNHTRVVETMQ 1601
Query: 493 NTDPATSASTVDVKPSPSAAEADFDIVTKGQVCEMTKEIADKTEKYNKCKQLLQDEKAKC 552
+T A S D E D + + + Q+ + A+ Y + +L++ +
Sbjct: 1602 STLDAEIRSRNDALRVKKKMEGDLNEM-EIQLNHANRLAAESLRNYRNTQGILKETQL-- 1658
Query: 553 NKYADELAKMELKWKEQVKIAE-NVKLELAEVQDNYKELKRSLEN---------PAERKM 602
+ D+ + + KEQ+ I E L AE+++ + L+++ + A ++
Sbjct: 1659 --HLDDALRGQEDLKEQLAIVERRANLLQAEIEELWATLEQTERSRKIAEQELLDASERV 1716
Query: 603 EGQNSQSPQCFKTCSEQNGYVLTL-SNAQPVLQYGNPYASQETRDGADGAFYPDEIQR 659
+ ++Q+ T + V L S + V+Q + + D A +E+++
Sbjct: 1717 QLLHTQNTSLINTKKKLENDVSQLQSEVEEVIQESRNAEEKAKKAITDAAMMAEELKK 1774
Score = 67.0 bits (162), Expect = 6e-11
Identities = 89/460 (19%), Positives = 195/460 (42%), Gaps = 46/460 (10%)
Query: 153 KIEKTMKEKEELLKLIAVLEKETAQLREQVGRMERELNHEKERCDQLQAEQKGLTEVTQS 212
++ K+ +++EL + + L KE L+ QV L +ERC+QL + L +
Sbjct: 865 ELAKSEAKRKELEEKMVTLLKEKNDLQLQVQSEADSLADAEERCEQLIKNKIQLEAKIKE 924
Query: 213 LKMENEEFKKRFSDATSKAHQLEEDIVSVTHKAIEKETELDSLKDKLKKAQHEREQLECQ 272
+ EE ++ ++ T+K +LE++ E + ++D L+ L K + E+ E +
Sbjct: 925 VTERAEEEEEINAELTAKKRKLEDE-------CSELKKDIDDLELTLAKVEKEKHATENK 977
Query: 273 LKTEKDEKE-LYKVHLKNTEIENTKLMSEVQTLKNLDGNKESV------ITHFKEEIGRL 325
+K +E L + K ++ + + QTL +L ++ V T ++++ L
Sbjct: 978 VKNLTEEMAGLDETIAKLSKEKKALQETHQQTLDDLQAEEDKVNILTKAKTKLEQQVDDL 1037
Query: 326 QLCLAEKENLQRTFLLTTSSKE-DTCFLKEQLRKAEEQVQATRQEVVFLAKELSDAVNVR 384
+ L +++ L+ E D +E E Q +++ E+S+ ++
Sbjct: 1038 EGSLEQEKKLRMDLERAKRKLEGDLKLAQESTMDMENDKQQLDEKLEKKEFEISNLIS-- 1095
Query: 385 DRTMADLHTARLENEKVKKQLADAVAEL--KLNAMKKDQDKTDTLEHELRREVEDLKLRL 442
+ D ++ +K K+L + EL ++ A + + K + +L RE+E++ RL
Sbjct: 1096 --KIEDEQAVEIQLQKKIKELQARIEELGEEIEAERASRAKAEKQRSDLSRELEEISERL 1153
Query: 443 QMA-------ADHYKEKFKECQRLQKQINKLSDQSANNNNVFTKKTGNQQKVNDASVNTD 495
+ A + K++ E Q+L++ + + + Q KK + ++
Sbjct: 1154 EEAGGATSAQVELNKKREAEFQKLRRDLEEATLQHEAMVAALRKKHADSMAELGEQID-- 1211
Query: 496 PATSASTVDVKPSPSAAEADFDIVTKGQVCEMTKEIADKTEKYNKCKQLLQDEKAKCNKY 555
+ V K +E + T +++ E +K K L+ C
Sbjct: 1212 ---NLQRVKQKLEKEKSELKME----------TDDLSSNAEAISKAKGNLE---KMCRSL 1255
Query: 556 ADELAKMELKWKEQVKIAENVKLELAEVQDNYKELKRSLE 595
D++++++ K +EQ ++ ++ + A +Q E R L+
Sbjct: 1256 EDQVSELKTKEEEQQRLINDLTAQRARLQTEAGEYSRQLD 1295
Score = 60.5 bits (145), Expect = 6e-09
Identities = 112/552 (20%), Positives = 211/552 (38%), Gaps = 69/552 (12%)
Query: 74 HYVEGSTVNCVLAFQGYYLPNDDGEFYQFCYVTHKGEIRGASTPFQFRASSPVEELLTME 133
H ++ S +C L + Y + Q E+ T ++ A EEL +
Sbjct: 1334 HALQSSRHDCDLLREQYEEEQEGKAELQRALSKANSEVAQWRTKYETDAIQRTEELEEAK 1393
Query: 134 -------DEGNSDMLVVTTKAGLLELKIEKTMKEKEELLKLIAVLEKETAQLREQVGRME 186
E + V K LE ++ E E+L+ + A L ++ +
Sbjct: 1394 KKLAQRLQEAEEHVEAVNAKCASLEKTKQRLQNEVEDLMLDVERSNAACAALDKKQRNFD 1453
Query: 187 RELNHEKERCDQLQAEQKGLTEVTQSLKMENEEFKKRFSDATSKAH-------QLEEDIV 239
+ L+ K++ ++ QAE + + ++SL E + K + ++ + L+++I
Sbjct: 1454 KVLSEWKQKYEETQAELEASQKESRSLSTELFKVKNVYEESLDQLETLRRENKNLQQEIS 1513
Query: 240 SVTHKAIEKETELDSLKDKLKKAQHEREQLECQLKTEKDEKELYKVHLKNTEIENTKLMS 299
+T + E ++ L +K+KK Q E+E+ E Q E+ E L E E K++
Sbjct: 1514 DLTEQIAEGGKQIHEL-EKIKK-QVEQEKCEIQAALEEAEASL--------EHEEGKILR 1563
Query: 300 EVQTLKNLDGNKESVITHFKEEIGRLQLCLAE-KENLQRTFLLTTSSKEDTCFLKEQ--- 355
L + + I EEI +L+ E +Q T S+ D +K++
Sbjct: 1564 IQLELNQVKSEVDRKIAEKDEEIDQLKRNHTRVVETMQSTLDAEIRSRNDALRVKKKMEG 1623
Query: 356 -LRKAEEQVQATRQEVVFLAKELSDAVNVRDRTMADLHTARLENEKVKKQLADAVAELKL 414
L + E Q+ + + + + T L A E +K+QL A+ E +
Sbjct: 1624 DLNEMEIQLNHANRLAAESLRNYRNTQGILKETQLHLDDALRGQEDLKEQL--AIVERRA 1681
Query: 415 NAMKKDQDKTDTLEHELRREVEDLKLRLQMAADHYKEKFKECQRLQKQINKLSDQSANNN 474
N L+ E+E+L L+ K +E +++ L Q N +
Sbjct: 1682 NL--------------LQAEIEELWATLEQTERSRKIAEQELLDASERVQLLHTQ--NTS 1725
Query: 475 NVFTKKTGNQQKVNDASVNTDPATSASTVD--VKPSPSAAE-ADFDIVTKGQVCEMTKEI 531
+ TKK + D + S V+ ++ S +A E A I + E K+
Sbjct: 1726 LINTKK----------KLENDVSQLQSEVEEVIQESRNAEEKAKKAITDAAMMAEELKKE 1775
Query: 532 ADKTEKYNKCKQLLQDEKAKCNKYADELAKMELKWKEQVKIAENVKLELAEVQDNYKELK 591
D + + K+ L+ DE ++ LK K ++ +++ +EL+
Sbjct: 1776 QDTSAHLERMKKNLEQTVKDLQHRLDEAEQLALK---------GGKKQIQKLEARVRELE 1826
Query: 592 RSLENPAERKME 603
+EN +R E
Sbjct: 1827 GEVENEQKRNAE 1838
Score = 53.1 bits (126), Expect = 1e-06
Identities = 74/363 (20%), Positives = 157/363 (43%), Gaps = 44/363 (12%)
Query: 255 LKDKLKKAQHEREQLECQLKTEKDEKELYKVHLKNTEIENTKLMSEVQTLKNLDGNKESV 314
+K LK A+ E+E + + +K + EL K K E+E E +
Sbjct: 839 IKPLLKSAETEKEMATMKEEFQKTKDELAKSEAKRKELE------------------EKM 880
Query: 315 ITHFKEEIGRLQLCLAEKENLQRTFLLTTSSKEDTCFLKEQLRKAEEQVQATRQEVVFLA 374
+T KE+ LQL + + + + + E+ C EQL K + Q++A +EV A
Sbjct: 881 VTLLKEK-NDLQLQVQSEAD-------SLADAEERC---EQLIKNKIQLEAKIKEVTERA 929
Query: 375 KELSDAVNVRDRTMADLHTARLENEKVKKQLADAVAELKLNAMKKDQDKTDTLEHELRRE 434
+E + A+L + + E +L + +L+L K +++K T E++++
Sbjct: 930 EE-------EEEINAELTAKKRKLEDECSELKKDIDDLELTLAKVEKEKHAT-ENKVKNL 981
Query: 435 VEDLKLRLQMAADHYKEKFKECQRLQKQINKLSDQSANNNNVFTKKTGNQQKVNDASVNT 494
E++ + A KEK + Q+ ++ L + N + KT +Q+V+D +
Sbjct: 982 TEEMAGLDETIAKLSKEKKALQETHQQTLDDLQAEEDKVNILTKAKTKLEQQVDDLEGSL 1041
Query: 495 DPATSASTVDVKPSPSAAEADFDIVTKGQV------CEMTKEIADKTEKYNKCKQLLQDE 548
+ +D++ + E D + + + ++ +++ K + + ++DE
Sbjct: 1042 EQEKKL-RMDLERAKRKLEGDLKLAQESTMDMENDKQQLDEKLEKKEFEISNLISKIEDE 1100
Query: 549 KAKCNKYADELAKMELKWKEQVKIAENVKLELAEVQDNYKELKRSLENPAERKMEGQNSQ 608
+A + ++ +++ + +E + E + A+ + +L R LE +ER E +
Sbjct: 1101 QAVEIQLQKKIKELQARIEELGEEIEAERASRAKAEKQRSDLSRELEEISERLEEAGGAT 1160
Query: 609 SPQ 611
S Q
Sbjct: 1161 SAQ 1163
Score = 45.8 bits (107), Expect = 2e-04
Identities = 33/130 (25%), Positives = 65/130 (50%), Gaps = 7/130 (5%)
Query: 171 LEKETAQLREQVGRMERELNHEKERCDQLQAEQKGLTEVTQSLKMENEEFKKRFSDATSK 230
++K A++RE G +E E E L+ ++ + E+T + EE +K
Sbjct: 1815 IQKLEARVRELEGEVENEQKRNAEAVKGLRKHERRVKELT----YQTEEDRKNVLRLQDL 1870
Query: 231 AHQLEEDIVSVTHKAIEKETELDSLKDKLKKAQHEREQLECQLKTEKDEKELYKVHLKNT 290
+L+ + S +A E E + ++ K +K QHE E E + + + E ++ K+ +K+
Sbjct: 1871 VDKLQAKVKSYKRQAEEAEEQSNANLSKFRKLQHELE--EAEERADIAESQVNKLRVKSR 1928
Query: 291 EIENTKLMSE 300
E+ +TK+ +E
Sbjct: 1929 EV-HTKISAE 1937
>gi|38045898 RAB6-interacting protein 2 isoform epsilon [Homo
sapiens]
Length = 1116
Score = 80.5 bits (197), Expect = 6e-15
Identities = 107/499 (21%), Positives = 211/499 (42%), Gaps = 53/499 (10%)
Query: 139 DMLVVTTKAGLLELKIEKTM---------KEKEELLKLIAVLEKETAQLREQVGRMEREL 189
D + + + GL +L+ E M +E+EE +K + V + ++ +V +++ EL
Sbjct: 388 DSKISSMERGLRDLEEEIQMLKSNGALSTEEREEEMKQMEVYRSHSKFMKNKVEQLKEEL 447
Query: 190 NHEKERCDQLQAEQKGLT----EVTQSLKMENEEF----------KKRFSDATSKAHQLE 235
+ ++ + ++L+ + GL +V Q L ++ E +FSD+ L+
Sbjct: 448 SSKEAQWEELKKKAAGLQAEIGQVKQELSRKDTELLALQTKLETLTNQFSDSKQHIEVLK 507
Query: 236 EDIVSVTHKAIEKETELDSLKDKLKKAQHEREQLECQLKTEKDEK--ELYKVH-----LK 288
E + + +A +TE+D+L+ +L++ + + Q++ +EK + ++H L
Sbjct: 508 ESLTAKEQRAAILQTEVDALRLRLEEKETMLNKKTKQIQDMAEEKGTQAGEIHDLKDMLD 567
Query: 289 NTEIENTKLMSEVQTLKNLDGNKESVITHFKEEIGRLQLCLAEKENLQRTFLLTTSSKED 348
E + L +++ L+ +KE ++ KE + LQ + T + KE
Sbjct: 568 VKERKVNVLQKKIENLQEQLRDKEKQMSSLKERVKSLQADTTNTDTALTTLEEALAEKER 627
Query: 349 TC-FLKEQLRKAEEQVQATRQEVVFLAKELSDAVNVRDRTMADLHTARLENEKVKKQLAD 407
T LKEQ + E + Q +E+ K+L D DL E E L +
Sbjct: 628 TIERLKEQRDRDEREKQ---EEIDNYKKDLKDLKEKVSLLQGDLS----EKEASLLDLKE 680
Query: 408 AVAELKLNAMKKDQDKTDTLEHELRREVED-LKLRLQMAADH--------YKEKFKECQR 458
+ L + +KKD + TLE L ++ E+ LK+ Q+ H E Q
Sbjct: 681 HASSLASSGLKKD-SRLKTLEIALEQKKEECLKMESQLKKAHEAALEARASPEMSDRIQH 739
Query: 459 LQKQINKLSDQSANNNNVFTKKTGNQQKVNDASVNTDPATSASTVDVKPSPS--AAEADF 516
L+++I + D+S+ + ++V + + D + VK A
Sbjct: 740 LEREITRYKDESSKAQAEVDRLLEILKEVENEKNDKDKKIAELERQVKDQNKKVANLKHK 799
Query: 517 DIVTKGQVCEMTKEIADKTEKYNKCKQLLQDEKAKCNKYADELAKMELKWKEQVKIAENV 576
+ V K + +M +E + + N Q LQD K D + ++E +E V+I
Sbjct: 800 EQVEKKKSAQMLEEARRREDNLNDSSQQLQD---SLRKKDDRIEELEEALRESVQITAER 856
Query: 577 KLELAEVQDNYKELKRSLE 595
++ LA+ + ++ +E
Sbjct: 857 EMVLAQEESARTNAEKQVE 875
Score = 75.5 bits (184), Expect = 2e-13
Identities = 95/455 (20%), Positives = 189/455 (41%), Gaps = 55/455 (12%)
Query: 137 NSDMLVVTTKAGLLELKIEKTMKEKEELLKLIAVLEKETAQLREQVGRMERELNHEKERC 196
++++L + TK L + + + E L + + E+ A L+ +V + L ++
Sbjct: 479 DTELLALQTKLETLTNQFSDSKQHIEVLKESLTAKEQRAAILQTEVDALRLRLEEKETML 538
Query: 197 DQLQAEQKGLTEVTQSLKMENEEFKKRFSDATSKAHQLEEDIVSVTHKAIEKETELDSLK 256
++ + + + E + E + K K + L++ I ++ + +KE ++ SLK
Sbjct: 539 NKKTKQIQDMAEEKGTQAGEIHDLKDMLDVKERKVNVLQKKIENLQEQLRDKEKQMSSLK 598
Query: 257 DKLKKAQ-----------------HEREQLECQLKTEKDEKELYKVHLKNTEIENTK--- 296
+++K Q E+E+ +LK ++D E K EI+N K
Sbjct: 599 ERVKSLQADTTNTDTALTTLEEALAEKERTIERLKEQRDRDE----REKQEEIDNYKKDL 654
Query: 297 --LMSEVQTLKNLDGNKESVITHFKEEIGRLQLCLAEKENLQRTFLLTTSSKEDTCF-LK 353
L +V L+ KE+ + KE L +K++ +T + K++ C ++
Sbjct: 655 KDLKEKVSLLQGDLSEKEASLLDLKEHASSLASSGLKKDSRLKTLEIALEQKKEECLKME 714
Query: 354 EQLRKAEEQVQATRQEVVFLAKELSDAVNVRDRTMADLHTARLENEKVKKQL-ADAVAEL 412
QL+KA E R + E+SD + +R + R ++E K Q D + E+
Sbjct: 715 SQLKKAHEAALEAR-----ASPEMSDRIQHLEREI-----TRYKDESSKAQAEVDRLLEI 764
Query: 413 KLNAMKKDQDKTDTLEHELRREVEDLKLRL-QMAADHYKEKFKECQRLQ---KQINKLSD 468
L ++ +++ D EL R+V+D ++ + EK K Q L+ ++ + L+D
Sbjct: 765 -LKEVENEKNDKDKKIAELERQVKDQNKKVANLKHKEQVEKKKSAQMLEEARRREDNLND 823
Query: 469 QSANNNNVFTKKTGNQQKVNDASVNTDPATSASTVDVKPSPSAAEADFDIVTKGQVCEMT 528
S + KK +++ +A + T+ + + SA
Sbjct: 824 SSQQLQDSLRKKDDRIEELEEALRESVQITAEREMVLAQEESAR------------TNAE 871
Query: 529 KEIADKTEKYNKCKQLLQDEKAKCNKYADELAKME 563
K++ + K KQ L+ KAK + LA+ E
Sbjct: 872 KQVEELLMAMEKVKQELESMKAKLSSTQQSLAEKE 906
Score = 63.5 bits (153), Expect = 7e-10
Identities = 107/486 (22%), Positives = 213/486 (43%), Gaps = 51/486 (10%)
Query: 150 LELKIE---KTMKEKEELLK-LIAVLEKE--TAQLREQVGRMERELNHEKERCDQLQAEQ 203
+EL+IE +T+ ++E +K L+ +L+ + +A+ E+ R L + L++
Sbjct: 291 MELRIETQKQTLNARDESIKKLLEMLQSKGLSAKATEEDHERTRRLAEAEMHVHHLESL- 349
Query: 204 KGLTEVTQSLKMENEEFKKRFSDATSKAHQLEEDIVSVTHKAIE-KETELDSLKDKLKKA 262
L + + M EE +RF +A A IE K++++ S++ L+
Sbjct: 350 --LEQKEKENSMLREEMHRRFENAPDSAK------TKALQTVIEMKDSKISSMERGLRDL 401
Query: 263 QHEREQLECQ--LKTEKDEKELYKVHLKNTEIENTKLMSEVQTLKNLDGNKESVITHFKE 320
+ E + L+ L TE+ E+E+ ++ + + + K ++V+ LK +KE+ K+
Sbjct: 402 EEEIQMLKSNGALSTEEREEEMKQMEVYRSHSKFMK--NKVEQLKEELSSKEAQWEELKK 459
Query: 321 EIGRLQLCLAE-KENLQR--TFLLTTSSKEDTCFLKEQLRKAEEQVQATRQEVVFLAKEL 377
+ LQ + + K+ L R T LL +K +T L Q +++ ++ ++ + AKE
Sbjct: 460 KAAGLQAEIGQVKQELSRKDTELLALQTKLET--LTNQFSDSKQHIEVLKESLT--AKEQ 515
Query: 378 SDAVNVRDRTMADLHTARLENE-----KVKKQLADAVAELKLNAMKKDQDKTDTLEHELR 432
A+ +T D RLE + K KQ+ D +AE K + D D L+ +
Sbjct: 516 RAAIL---QTEVDALRLRLEEKETMLNKKTKQIQD-MAEEKGTQAGEIHDLKDMLDVK-E 570
Query: 433 REVEDLKLRLQMAADHYKEKFKECQRLQKQINKLSDQSANNNNVFT-------KKTGNQQ 485
R+V L+ +++ + ++K K+ L++++ L + N + T +K +
Sbjct: 571 RKVNVLQKKIENLQEQLRDKEKQMSSLKERVKSLQADTTNTDTALTTLEEALAEKERTIE 630
Query: 486 KVNDASVNTDPATSASTVDVKPSPSAAEADFDIVTKGQVCEMTKEIADKTEKYNKCKQ-- 543
++ + + D +D + + +G + E + D E +
Sbjct: 631 RLKEQR-DRDEREKQEEIDNYKKDLKDLKEKVSLLQGDLSEKEASLLDLKEHASSLASSG 689
Query: 544 LLQDEKAKCNKYADELAKME-LKWKEQVKIAENVKLEL---AEVQDNYKELKRSLENPAE 599
L +D + K + A E K E LK + Q+K A LE E+ D + L+R + +
Sbjct: 690 LKKDSRLKTLEIALEQKKEECLKMESQLKKAHEAALEARASPEMSDRIQHLEREITRYKD 749
Query: 600 RKMEGQ 605
+ Q
Sbjct: 750 ESSKAQ 755
Score = 58.5 bits (140), Expect = 2e-08
Identities = 66/320 (20%), Positives = 128/320 (40%), Gaps = 51/320 (15%)
Query: 150 LELKIEKTMKEKEELLKL--IAVLEKETAQLREQVGRMERELNHEKERCDQLQAEQKGLT 207
LE K E+ +K + +L K A+ + + ++ +++ +ERE+ K+ + QAE L
Sbjct: 703 LEQKKEECLKMESQLKKAHEAALEARASPEMSDRIQHLEREITRYKDESSKAQAEVDRLL 762
Query: 208 EVTQSLKMENEEFKKRFSDATSKAHQLEEDIVSVTHK--------------AIEKETELD 253
E+ + ++ E + K+ ++ + + + ++ HK A +E L+
Sbjct: 763 EILKEVENEKNDKDKKIAELERQVKDQNKKVANLKHKEQVEKKKSAQMLEEARRREDNLN 822
Query: 254 S----LKDKLKKAQHEREQLECQLKTEKDEKELYKVHLKNTEIENTKLMSEVQTLKNLDG 309
L+D L+K E+LE L+ ++ L E T +V+ L
Sbjct: 823 DSSQQLQDSLRKKDDRIEELEEALRESVQITAEREMVLAQEESARTNAEKQVEELLMAME 882
Query: 310 NKESVITHFKEEIGRLQLCLAEKEN------------------LQRTFLLTTSSKEDTCF 351
+ + K ++ Q LAEKE +++ LL S++D
Sbjct: 883 KVKQELESMKAKLSSTQQSLAEKETHLTNLRAERRKHLEEVLEMKQEALLAAISEKDANI 942
Query: 352 ----LKEQLRKAEEQVQATRQEVVFLAKELSDAVNVRDRTMAD---------LHTARLEN 398
L +K +E+V A ++E L ++L R + MAD H+ + +
Sbjct: 943 ALLELSSSKKKTQEEVAALKREKDRLVQQLKQQTQNRMKLMADNYEDDHFKSSHSNQTNH 1002
Query: 399 EKVKKQLADAVAELKLNAMK 418
+ Q+ + EL N K
Sbjct: 1003 KPSPDQIIQPLLELDQNRSK 1022
>gi|58530840 desmoplakin isoform I [Homo sapiens]
Length = 2871
Score = 79.7 bits (195), Expect = 1e-14
Identities = 89/507 (17%), Positives = 222/507 (43%), Gaps = 46/507 (9%)
Query: 124 SPVEELLTMEDEGNSDMLVVTTKAGLLELKIEKTMKEKEELLKL----IAVLEKETAQLR 179
SP +L + ++ + + T++G + + +K E+L KL I VLE+E R
Sbjct: 987 SPSGVILQEAADVHARYIELLTRSGDYYRFLSEMLKSLEDL-KLKNTKIEVLEEELRLAR 1045
Query: 180 EQVGR-------MERELNHEKERCDQLQAEQKGLTEVTQSLKMENEEFKKRFSDATSKAH 232
+ +++ L + C Q +A+ L E+ + +++ + K+ +
Sbjct: 1046 DANSENCNKNKFLDQNLQKYQAECSQFKAKLASLEELKRQAELDGKSAKQNLDKCYGQIK 1105
Query: 233 QLEEDIVSVTHKAIEKETELDSLKDKLKKAQHEREQLECQLKTEKDEKELYK------VH 286
+L E I +T++ +++ S++D+ + +++ +QL+ + EK+ K +
Sbjct: 1106 ELNEKITRLTYEIEDEKRRRKSVEDRFDQQKNDYDQLQKARQCEKENLGWQKLESEKAIK 1165
Query: 287 LKNTEIENTKLMSEVQTLKNLDGNKE--SVITHFKEEIGRLQLCLAEKENLQRTFL--LT 342
K EIE +++ + + + + E V H+ EE+ L+ + N+ +T + ++
Sbjct: 1166 EKEYEIERLRVLLQEEGTRKREYENELAKVRNHYNEEMSNLRNKYETEINITKTTIKEIS 1225
Query: 343 TSSKEDTCFLKEQLRKAEEQVQATRQEVVFLAKELSDAVNVRDRTMADLHTARLENEKVK 402
++D+ L+ QL + + + + E+V L + A R R + + ++
Sbjct: 1226 MQKEDDSKNLRNQLDRLSRENRDLKDEIVRLNDSILQATEQRRRAEENALQQKACGSEIM 1285
Query: 403 KQLADAVAELKLNAMKKDQDKT---DTLEHELRREVEDLKLRLQMAADHYKEKFKECQRL 459
++ ELK ++ +D +LE E + ++D ++ ++E+ K
Sbjct: 1286 QKKQHLEIELKQVMQQRSEDNARHKQSLE-EAAKTIQDKNKEIERLKAEFQEEAKRRWEY 1344
Query: 460 QKQINKLSDQSANNNNVFTKKTGNQQKVNDASVNTDPATSASTVDVKPSPSAAEADFDIV 519
+ +++K+ ++ + + + K + ++N T D S A D +
Sbjct: 1345 ENELSKV--RNNYDEEIISLKNQFETEINITKTTIHQLTMQKEEDT----SGYRAQIDNL 1398
Query: 520 TK------GQVCEMTKEIADKTEKYNKCKQLLQDEKAKCNKYADELAKMELKWKE--QVK 571
T+ ++ + + TE + ++ +Q +KA ++ + ++E++ ++ Q++
Sbjct: 1399 TRENRSLSEEIKRLKNTLTQTTENLRRVEEDIQQQKATGSEVSQRKQQLEVELRQVTQMR 1458
Query: 572 IAENVKLELA------EVQDNYKELKR 592
E+V+ + + +QD KE++R
Sbjct: 1459 TEESVRYKQSLDDAAKTIQDKNKEIER 1485
Score = 73.2 bits (178), Expect = 9e-13
Identities = 107/546 (19%), Positives = 231/546 (42%), Gaps = 77/546 (14%)
Query: 127 EELLTMEDEGNSDMLVVTTKAGLLELK-----------IEKTMKEKEELLKLIAVLEKET 175
EE+++++++ +++ + T L ++ I+ +E L + I L+
Sbjct: 1357 EEIISLKNQFETEINITKTTIHQLTMQKEEDTSGYRAQIDNLTRENRSLSEEIKRLKNTL 1416
Query: 176 AQLREQVGRMERELNHEK-------ERCDQLQAEQKGLTEVTQSLKMENEEFKKRFSDAT 228
Q E + R+E ++ +K +R QL+ E L +VTQ E+ +K+ DA
Sbjct: 1417 TQTTENLRRVEEDIQQQKATGSEVSQRKQQLEVE---LRQVTQMRTEESVRYKQSLDDAA 1473
Query: 229 SKAHQLEEDIVSVTHKAIEKET-ELDSLKDKLKKAQHEREQLECQLKTEKDEKELYKVHL 287
++I + + I+KET + L+D+ A+ +R Q + Q + + K L
Sbjct: 1474 KTIQDKNKEIERLK-QLIDKETNDRKCLEDE--NARLQRVQYDLQKANSSATETINK--L 1528
Query: 288 KNTEIENTKLMSEVQTLKNLDGNKESVITHFKEEIGRLQLCLAE-KENLQRTFLLTTSSK 346
K E E T+L + + + K+ IT F+ + LQL + +E L R L ++
Sbjct: 1529 KVQEQELTRLRIDYERVSQERTVKDQDITRFQNSLKELQLQKQKVEEELNR---LKRTAS 1585
Query: 347 EDTCF---LKEQLRKAEEQVQATRQEVVFLAKELSDAVNVRDRTMADLHTAR-------L 396
ED+C L+E+L ++ ++ L ++L A V+ R+ DL R
Sbjct: 1586 EDSCKRKKLEEELEGMRRSLKEQAIKITNLTQQLEQASIVKKRSEDDLRQQRDVLDGHLR 1645
Query: 397 ENEKVKKQLADAVAELKLNAMKKDQDKTDTLEHELRREVEDLKLRLQMAADHYKEKFKEC 456
E ++ +++L +E++ + Q++ + LR E + ++ + E E
Sbjct: 1646 EKQRTQEELRRLSSEVEALRRQLLQEQESVKQAHLRNE--HFQKAIEDKSRSLNESKIEI 1703
Query: 457 QRLQKQINKLSDQSANNNNVFTKKTGNQQKVNDASVNTDPATSASTVDVKPSPSAAEADF 516
+RLQ L+ + + D +A+ ++++ S +
Sbjct: 1704 ERLQSLTENLTKEHLMLEEELRNLRLEYDDLRRGRSEADSDKNATILELR-SQLQISNNR 1762
Query: 517 DIVTKGQVCEMTKE---IADKTEKY---------------NKCKQLLQD----------- 547
+ +G + ++ +E + + EK+ N+C Q++Q+
Sbjct: 1763 TLELQGLINDLQRERENLRQEIEKFQKQALEASNRIQESKNQCTQVVQERESLLVKIKVL 1822
Query: 548 --EKAKCNKYADELAKMELKWKEQVKIAENVKLELAEVQDNYKELKR--SLENPAERKME 603
+KA+ + DEL + + + + ++ + ++ E ++Q++ + K S + A RK+E
Sbjct: 1823 EQDKARLQRLEDELNRAKSTLEAETRVKQRLECEKQQIQNDLNQWKTQYSRKEEAIRKIE 1882
Query: 604 GQNSQS 609
+ +S
Sbjct: 1883 SEREKS 1888
Score = 57.0 bits (136), Expect = 7e-08
Identities = 108/517 (20%), Positives = 199/517 (38%), Gaps = 93/517 (17%)
Query: 161 KEELLKLIAVLEKETAQLREQVGRMERELNHEKERCDQL-----------QAEQKGLTEV 209
+ EL K+ ++E L+ Q E E+N K QL +A+ LT
Sbjct: 1345 ENELSKVRNNYDEEIISLKNQ---FETEINITKTTIHQLTMQKEEDTSGYRAQIDNLTRE 1401
Query: 210 TQSLKMENEEFKKRFSDATSKAHQLEEDIVSVTHKAIEKETELDSLKDKLKKAQHEREQL 269
+SL E + K + T ++EEDI E L+ +L++ R +
Sbjct: 1402 NRSLSEEIKRLKNTLTQTTENLRRVEEDIQQQKATGSEVSQRKQQLEVELRQVTQMRTEE 1461
Query: 270 ECQLKTEKDEKELYKVHLKNTEIENTKLMSEVQTLKNLDGNKESVITHFKEEIGRLQLCL 329
+ K D+ + KN EIE K + + +T N + ++E RLQ
Sbjct: 1462 SVRYKQSLDDAAK-TIQDKNKEIERLKQLIDKET------NDRKCL---EDENARLQ--- 1508
Query: 330 AEKENLQRTFLLTTSSKEDTCFLKEQLRKAEEQVQATRQEVVFLAKELSDAVNVRDRTMA 389
+Q SS +T +L+ E+++ R + +++E RT+
Sbjct: 1509 ----RVQYDLQKANSSATETI---NKLKVQEQELTRLRIDYERVSQE---------RTVK 1552
Query: 390 DLHTARLENEKVKKQLADAVAELKLNAMKK----DQDKTDTLEHEL-------------- 431
D R +N + QL E +LN +K+ D K LE EL
Sbjct: 1553 DQDITRFQNSLKELQLQKQKVEEELNRLKRTASEDSCKRKKLEEELEGMRRSLKEQAIKI 1612
Query: 432 --------------RREVEDLKLRLQMAADHYKEKFKECQRLQKQINKLSDQSANNNNVF 477
+R +DL+ + + H +EK QR Q+++ +LS +
Sbjct: 1613 TNLTQQLEQASIVKKRSEDDLRQQRDVLDGHLREK----QRTQEELRRLSSEVEALRRQL 1668
Query: 478 TKKTGNQQKVNDASVNTDPATSASTVDVKPSPSAAEADFDIVTKGQVCE-MTKEIADKTE 536
++ Q+ V A + + A ++ K S S E+ +I + E +TKE E
Sbjct: 1669 LQE---QESVKQAHLRNEHFQKA--IEDK-SRSLNESKIEIERLQSLTENLTKEHLMLEE 1722
Query: 537 KYNKCKQLLQDEKAKCNKYADELAKMELKWKEQVKIAENVKLELA----EVQDNYKELKR 592
+ + D + ++ + L+ + Q++I+ N LEL ++Q + L++
Sbjct: 1723 ELRNLRLEYDDLRRGRSEADSDKNATILELRSQLQISNNRTLELQGLINDLQRERENLRQ 1782
Query: 593 SLENPAERKMEGQN---SQSPQCFKTCSEQNGYVLTL 626
+E ++ +E N QC + E+ ++ +
Sbjct: 1783 EIEKFQKQALEASNRIQESKNQCTQVVQERESLLVKI 1819
Score = 52.4 bits (124), Expect = 2e-06
Identities = 42/152 (27%), Positives = 78/152 (51%), Gaps = 17/152 (11%)
Query: 156 KTMKEKEELLKLIAVLEKETAQLREQVGRMERELNHEKERCDQLQAEQKGLTEVTQSLKM 215
+ ++E+E LL I VLE++ A+L+ R+E ELN K L+AE T V Q L+
Sbjct: 1807 QVVQERESLLVKIKVLEQDKARLQ----RLEDELNRAK---STLEAE----TRVKQRLEC 1855
Query: 216 ENEEFKKRFSDATSKAHQLEEDIVSVTHKAIEKETELDSLKDKLKKAQHEREQLE--CQL 273
E ++ + + ++ + EE I + + + E E +SL+ ++++ Q E +++E C+
Sbjct: 1856 EKQQIQNDLNQWKTQYSRKEEAIRKIESEREKSEREKNSLRSEIERLQAEIKRIEERCRR 1915
Query: 274 KTEKDEKELYKVHLKNTEIENTKLMSEVQTLK 305
K E +E E E ++ E+ L+
Sbjct: 1916 KLEDSTRETQ----SQLETERSRYQREIDKLR 1943
Score = 48.5 bits (114), Expect = 2e-05
Identities = 73/357 (20%), Positives = 150/357 (42%), Gaps = 42/357 (11%)
Query: 280 KELYKVHLKNTEIE----NTKLMSEVQTLKNLDGNK--ESVITHFKEEIGRLQLCLAEKE 333
K L + LKNT+IE +L + + +N + NK + + ++ E + + LA E
Sbjct: 1022 KSLEDLKLKNTKIEVLEEELRLARDANS-ENCNKNKFLDQNLQKYQAECSQFKAKLASLE 1080
Query: 334 NLQRTFLLTTSSKEDTCFLKEQLRKAEEQVQATRQEVVFLAKELSDAV----NVRDR--- 386
L+R L S K+ L K Q++ +++ L E+ D +V DR
Sbjct: 1081 ELKRQAELDGKSA------KQNLDKCYGQIKELNEKITRLTYEIEDEKRRRKSVEDRFDQ 1134
Query: 387 --------------TMADLHTARLENEKVKKQLADAVAELKLNAMKKDQDKTDTLEHELR 432
+L +LE+EK K+ + L++ ++ K + E+EL
Sbjct: 1135 QKNDYDQLQKARQCEKENLGWQKLESEKAIKEKEYEIERLRVLLQEEGTRKRE-YENELA 1193
Query: 433 REVEDLKLRLQMAADHYKEKFKECQRLQKQIN-KLSDQSANNNNVFTKKTGNQQKVNDAS 491
+ + + Y+ + + K+I+ + D S N N + + + + D
Sbjct: 1194 KVRNHYNEEMSNLRNKYETEINITKTTIKEISMQKEDDSKNLRNQLDRLSRENRDLKDEI 1253
Query: 492 VNTDPATSASTVDVKPSPSAA----EADFDIVTKGQ--VCEMTKEIADKTEKYNKCKQLL 545
V + + +T + + A +I+ K Q E+ + + ++E + KQ L
Sbjct: 1254 VRLNDSILQATEQRRRAEENALQQKACGSEIMQKKQHLEIELKQVMQQRSEDNARHKQSL 1313
Query: 546 QDEKAKCNKYADELAKMELKWKEQVKIAENVKLELAEVQDNYKELKRSLENPAERKM 602
++ E+ +++ +++E+ K + EL++V++NY E SL+N E ++
Sbjct: 1314 EEAAKTIQDKNKEIERLKAEFQEEAKRRWEYENELSKVRNNYDEEIISLKNQFETEI 1370
>gi|41872583 Rho-associated, coiled-coil containing protein kinase 2
[Homo sapiens]
Length = 1388
Score = 79.3 bits (194), Expect = 1e-14
Identities = 110/494 (22%), Positives = 215/494 (43%), Gaps = 49/494 (9%)
Query: 127 EELLTMEDEGNSDMLV---VTTKAGLLELKIEKTMKEKEELLKL-------IAVLEKETA 176
++L T+E+ +++M + K + ++EKT KE EE + L + LE+E A
Sbjct: 447 KKLYTLEEHLSNEMQAKEELEQKCKSVNTRLEKTAKELEEEITLRKSVESALRQLEREKA 506
Query: 177 QLREQVGRMERELNHEKERCDQLQAEQKGLTEVTQSLKMENEEFKKRFSDATSKAHQLEE 236
L+ + +R+ +HE ++ L+ + L + + LK N+ + +T K +QL+
Sbjct: 507 LLQHKNAEYQRKADHEADKKRNLENDVNSLKDQLEDLKKRNQNSQ----ISTEKVNQLQR 562
Query: 237 DIVSVTHKAIEKETELDSLKDKLKKAQHEREQLECQLKTEKDEKELYKVHLKNTEIENTK 296
+ T+ + E++ + +L+K Q E + QL E + ++L KN +E K
Sbjct: 563 QL-DETNALLRTESDTAA---RLRKTQAESSKQIQQL--ESNNRDLQD---KNCLLETAK 613
Query: 297 LMSEVQTLKNLDGNKESV---ITHFKEEIGRLQ--LCLAEKENLQRTFLLTTSSKEDTCF 351
L E + + NL ES TH E I LQ +C E E+L+ +L + +
Sbjct: 614 LKLEKEFI-NLQSALESERRDRTHGSEIINDLQGRICGLE-EDLKNGKILLAKVELEKRQ 671
Query: 352 LKEQLRKAEEQVQATRQEVVFLAKELSDAVNVRDRTMADLHTARLENEKVKKQLADAVAE 411
L+E+ E++ ++ + K + ++ + H A K ++ +++ E
Sbjct: 672 LQERFTDLEKEKSNMEIDMTYQLKVIQQSLEQEEAE----HKATKARLADKNKIYESIEE 727
Query: 412 LKLNAMKKDQDKTDTLEHELRREVEDLKLRLQMAADHYKEKFKECQRLQKQINKLSDQSA 471
K AM K+ +K E L+++VE+L L + K+ Q+ ++ K D
Sbjct: 728 AKSEAM-KEMEKKLLEERTLKQKVENLLLEAEKRCSLLDCDLKQSQQKINELLKQKDVLN 786
Query: 472 NNNNVFTKK----------TGNQQKVNDASVNTDPATSASTVDVKPSPSAAEADFDIVTK 521
+ T K T N K+ VNT S +K + + + +
Sbjct: 787 EDVRNLTLKIEQETQKRCLTQNDLKMQTQQVNT---LKMSEKQLKQENNHL-MEMKMNLE 842
Query: 522 GQVCEMTKEIADKTEKYNKCKQLLQDEKAKCNKYADELAKMELKWKEQVKIAENVKLELA 581
Q E+ KE D + + + L+ E+ Y ++ +++ + +E+ K+ + ++ +
Sbjct: 843 KQNAELRKERQDADGQMKELQDQLEAEQYFSTLYKTQVRELKEECEEKTKLGKELQQKKQ 902
Query: 582 EVQDNYKELKRSLE 595
E+QD L LE
Sbjct: 903 ELQDERDSLAAQLE 916
Score = 68.9 bits (167), Expect = 2e-11
Identities = 87/375 (23%), Positives = 169/375 (45%), Gaps = 50/375 (13%)
Query: 128 ELLTMEDEGNSDMLVVTTKAGLLELKIEKTMKEK----EELLKLIAVLEKETAQ---LRE 180
E L +E E +L K + KI + +K+K E++ L +E+ET + +
Sbjct: 751 ENLLLEAEKRCSLLDCDLKQS--QQKINELLKQKDVLNEDVRNLTLKIEQETQKRCLTQN 808
Query: 181 QVGRMERELNHEKERCDQLQAEQKGLTEVTQSLKMENEEFKKRFSDATSKAHQLEEDI-- 238
+ +++N K QL+ E L E+ +L+ +N E +K DA + +L++ +
Sbjct: 809 DLKMQTQQVNTLKMSEKQLKQENNHLMEMKMNLEKQNAELRKERQDADGQMKELQDQLEA 868
Query: 239 -----------VSVTHKAIEKETEL-DSLKDKLKKAQHEREQLECQLK---TEKDEKELY 283
V + E++T+L L+ K ++ Q ER+ L QL+ T+ D ++L
Sbjct: 869 EQYFSTLYKTQVRELKEECEEKTKLGKELQQKKQELQDERDSLAAQLEITLTKADSEQLA 928
Query: 284 K--VHLKNTEIENTKLMSEVQTLKNLDGNKESVITHFKEEIGRLQLCLAEKENLQRTFLL 341
+ + +++E K+M E++ KE + H K+E+ +A E RT
Sbjct: 929 RSIAEEQYSDLEKEKIMKELEI-------KEMMARH-KQELTEKDATIASLEETNRTL-- 978
Query: 342 TTSSKEDTCFLKEQLRKAEEQVQATRQEVVFLAKELSDAVNVRDRTMADLHTARLENEKV 401
TS + KE+L + VQ +++ L E A ++ + L T R +
Sbjct: 979 -TSDVANLANEKEELNNKLKDVQ---EQLSRLKDEEISAAAIKAQFEKQLLTER----TL 1030
Query: 402 KKQLADAVAELKLNAMKKDQDKTDTLEHELRREVEDLKLRLQMAADHYKEKFKECQRLQK 461
K Q + +AE+ +K+ K R+E E+ KL +++ ++ K ++ + QK
Sbjct: 1031 KTQAVNKLAEI---MNRKEPVKRGNDTDVRRKEKENRKLHMELKSEREK-LTQQMIKYQK 1086
Query: 462 QINKLSDQSANNNNV 476
++N++ Q A + +
Sbjct: 1087 ELNEMQAQIAEESQI 1101
Score = 45.4 bits (106), Expect = 2e-04
Identities = 90/435 (20%), Positives = 175/435 (40%), Gaps = 48/435 (11%)
Query: 186 ERELNHEKERCDQLQAEQKGLTEVTQSLKMENEEFKKRFSDATSKAHQLEEDIVSVTHKA 245
E L + C + + Q E +Q ++ + ++ S+ +LE+ SV +
Sbjct: 418 ENLLLSDSPSCRETDSIQSRKNEESQEIQKKLYTLEEHLSNEMQAKEELEQKCKSVNTRL 477
Query: 246 IEKETELDSLKDKLKKAQHEREQLECQLKTEKDEKELYKVHLKNTEIENTKLMSEVQTLK 305
+ EL+ K + QLE + + + Y+ + + L ++V +LK
Sbjct: 478 EKTAKELEEEITLRKSVESALRQLEREKALLQHKNAEYQRKADHEADKKRNLENDVNSLK 537
Query: 306 N-----LDGNKESVITHFKEEIGRLQLCLAEKENLQRTFLLTTSSKEDTCFLKEQLRKAE 360
+ N+ S I+ E++ +LQ L E L RT + DT +LRK +
Sbjct: 538 DQLEDLKKRNQNSQIS--TEKVNQLQRQLDETNALLRT-------ESDTA---ARLRKTQ 585
Query: 361 EQVQATRQEVVFLAKELSDAVNVRDRTMADLHTARLENEKVKKQLADAVAELKLNAMKKD 420
+ Q++ ++L D + L TA+L+ EK L A L + ++D
Sbjct: 586 AESSKQIQQLESNNRDLQDKNCL-------LETAKLKLEKEFINLQSA-----LESERRD 633
Query: 421 QDKTDTLEHELRREV----EDLKLRLQMAADHYKEKFKECQRLQKQINKLSDQSANNNNV 476
+ + ++L+ + EDLK + A EK ++LQ++ L + +N
Sbjct: 634 RTHGSEIINDLQGRICGLEEDLKNGKILLAKVELEK----RQLQERFTDLEKEKSNMEID 689
Query: 477 FTKKTGNQQKVNDASVNTDPATSASTVDVKPSPSAAEADFDIVTKGQVCEMTKEIADKTE 536
T Q KV S+ + A +T + + + EM K++ ++
Sbjct: 690 MT----YQLKVIQQSLEQEEAEHKATKARLADKNKIYESIEEAKSEAMKEMEKKLLEERT 745
Query: 537 KYNKCKQLLQDEKAKCNKYADELAKMELKWKEQVKIAENVKLELAEVQDNYKELKRSLEN 596
K + LL + + +C+ L +LK +Q KI E +K + + ++ + L +E
Sbjct: 746 LKQKVENLLLEAEKRCS-----LLDCDLKQSQQ-KINELLK-QKDVLNEDVRNLTLKIEQ 798
Query: 597 PAERKMEGQNSQSPQ 611
+++ QN Q
Sbjct: 799 ETQKRCLTQNDLKMQ 813
>gi|153791586 myosin, heavy chain 2, skeletal muscle, adult [Homo
sapiens]
Length = 1941
Score = 79.3 bits (194), Expect = 1e-14
Identities = 104/514 (20%), Positives = 222/514 (43%), Gaps = 62/514 (12%)
Query: 126 VEELLTMEDEGNSDMLVVTTKAGLLELKIEKTMKEKEELLKLIAVLEKETAQLREQVGRM 185
V E E+E N+++ T K LE + + K+ ++L +A +EKE +V +
Sbjct: 928 VTERAEDEEEINAEL---TAKKRKLEDECSELKKDIDDLELTLAKVEKEKHATENKVKNL 984
Query: 186 ERELNHEKERCDQLQAEQKGLTEVTQSLKMENEEFKKRFSDATSKAHQLEEDIVSVTHKA 245
E+ E +L E+K L E Q T Q EED V+ KA
Sbjct: 985 TEEMAGLDETIAKLTKEKKALQEAHQQ---------------TLDDLQAEEDKVNTLTKA 1029
Query: 246 -IEKETELDSLKDKLKKAQHEREQLE-CQLKTEKD-------------EKELYKVHLKNT 290
I+ E ++D L+ L++ + R LE + K E D EK+ LK
Sbjct: 1030 KIKLEQQVDDLEGSLEQEKKLRMDLERAKRKLEGDLKLAQESIMDIENEKQQLDEKLKKK 1089
Query: 291 EIENTKLMSEVQTLKNLDGNKESVITHFKEEIGRLQLCLAE-KENLQRTFLLTTSSKEDT 349
E E + L S+++ +++++ +++I LQ + E +E ++ +++
Sbjct: 1090 EFEISNLQSKIE-------DEQALGIQLQKKIKELQARIEELEEEIEAERASRAKAEKQR 1142
Query: 350 CFLKEQLRKAEEQVQ----ATRQEVVFLAKELSDAVNVRDRTMADLHTARLENE----KV 401
L +L + E+++ AT ++ K ++ +R DL A L++E +
Sbjct: 1143 SDLSRELEEISERLEEAGGATSAQIEMNKKREAEFQKMR----RDLEEATLQHEATAATL 1198
Query: 402 KKQLADAVAEL--KLNAMKKDQDKTDTLEHELRREVEDLKLRLQMAADHYKEKFKECQRL 459
+K+ AD+VAEL +++ +++ + K + + E++ E++DL ++ + K C+ L
Sbjct: 1199 RKKHADSVAELGEQIDNLQRVKQKLEKEKSEMKMEIDDLASNVETVSKAKGNLEKMCRTL 1258
Query: 460 QKQINKLSDQSANNNNVFTKKTGNQQKVNDASVNTDPATSASTVDVKPSPSAAEADFDIV 519
+ Q+++L + + T + + + T+ + +D K + + +
Sbjct: 1259 EDQLSELKSKEEEQQRLINDLTAQRGR-----LQTESGEFSRQLDEKEALVSQLSRGKQA 1313
Query: 520 TKGQVCEMTKEIADKTEKYNKCKQLLQDEKAKCNKYADELAKMELKWKEQVKIAENVKLE 579
Q+ E+ +++ ++ + N LQ + C+ ++ + + E + E
Sbjct: 1314 FTQQIEELKRQLEEEIKAKNALAHALQSSRHDCDLLREQYEEEQESKAELQRALSKANTE 1373
Query: 580 LAEVQDNYK--ELKRSLENPAERKMEGQNSQSPQ 611
+A+ + Y+ ++R+ E +K Q Q+ +
Sbjct: 1374 VAQWRTKYETDAIQRTEELEEAKKKLAQRLQAAE 1407
Score = 75.1 bits (183), Expect = 2e-13
Identities = 106/499 (21%), Positives = 218/499 (43%), Gaps = 54/499 (10%)
Query: 135 EGNSDMLVVTTKAGLLELKIEKTMKEKEELLKLIAVLEKETAQLREQVGRMERELNHEKE 194
E +M + + ++ ++ K+ +++EL + + L KE L+ QV L +E
Sbjct: 850 ETEKEMATMKEEFQKIKDELAKSEAKRKELEEKMVTLLKEKNDLQLQVQAEAEGLADAEE 909
Query: 195 RCDQL-----QAEQKGLTEVTQSLKMENEEFKKRFSDATSKAHQLEEDIVSVTHKAIEKE 249
RCDQL Q E K + EVT+ + E+EE + ++ T+K +LE++ E +
Sbjct: 910 RCDQLIKTKIQLEAK-IKEVTE--RAEDEE--EINAELTAKKRKLEDE-------CSELK 957
Query: 250 TELDSLKDKLKKAQHEREQLECQLKTEKDEKE-LYKVHLKNTEIENTKLMSEVQTLKNLD 308
++D L+ L K + E+ E ++K +E L + K T+ + + QTL +L
Sbjct: 958 KDIDDLELTLAKVEKEKHATENKVKNLTEEMAGLDETIAKLTKEKKALQEAHQQTLDDLQ 1017
Query: 309 GNKESVITHFKEEIGRLQLCLAEKENLQRTFLLTTSSKEDTCFLKEQLRKAEEQVQATRQ 368
++ V T K +I Q + +L++ L + L+ L+ A+E +
Sbjct: 1018 AEEDKVNTLTKAKIKLEQQVDDLEGSLEQEKKLRMDLERAKRKLEGDLKLAQESIMDIEN 1077
Query: 369 EVVFLAKELS----DAVNVRDRTMADLHTARLENEKVKKQLADAVAEL--KLNAMKKDQD 422
E L ++L + N++ + + D ++ +K K+L + EL ++ A + +
Sbjct: 1078 EKQQLDEKLKKKEFEISNLQSK-IEDEQALGIQLQKKIKELQARIEELEEEIEAERASRA 1136
Query: 423 KTDTLEHELRREVEDLKLRLQMAADHYKEKFKECQRLQKQINKLSDQSANNNNVFTKKTG 482
K + +L RE+E++ RL+ A + + ++ + + K+
Sbjct: 1137 KAEKQRSDLSRELEEISERLEEAGGATSAQIEMNKKREAEFQKM---------------- 1180
Query: 483 NQQKVNDASVNTDPATSASTVDVKPSPSAAEADFDIVTKGQV--------CEMTKEIADK 534
++ + +A++ + +A+T+ K + S AE I +V EM EI D
Sbjct: 1181 -RRDLEEATLQHE--ATAATLRKKHADSVAELGEQIDNLQRVKQKLEKEKSEMKMEIDDL 1237
Query: 535 TEKYNKCKQLLQDEKAKCNKYADELAKMELKWKEQVKIAENVKLELAEVQDNYKELKRSL 594
+ + + C D+L++++ K +EQ ++ ++ + +Q E R L
Sbjct: 1238 ASNVETVSKAKGNLEKMCRTLEDQLSELKSKEEEQQRLINDLTAQRGRLQTESGEFSRQL 1297
Query: 595 ENPAERKMEGQNSQSPQCF 613
+ + + Q S+ Q F
Sbjct: 1298 DE--KEALVSQLSRGKQAF 1314
Score = 60.8 bits (146), Expect = 5e-09
Identities = 125/606 (20%), Positives = 235/606 (38%), Gaps = 121/606 (19%)
Query: 74 HYVEGSTVNCVLAFQGYYLPNDDGEFYQFCYVTHKGEIRGASTPFQFRASSPVEELLTME 133
H ++ S +C L + Y + Q E+ T ++ A EEL +
Sbjct: 1337 HALQSSRHDCDLLREQYEEEQESKAELQRALSKANTEVAQWRTKYETDAIQRTEELEEAK 1396
Query: 134 DE-------GNSDMLVVTTKAGLLELKIEKTMKEKEELLKLIAVLEKETAQLREQVGRME 186
+ + V K LE ++ E E+L+ + A L ++ +
Sbjct: 1397 KKLAQRLQAAEEHVEAVNAKCASLEKTKQRLQNEVEDLMLDVERTNAACAALDKKQRNFD 1456
Query: 187 RELNHEKERCDQ----LQAEQKGLTEV-----------------TQSLKMENEEFKKRFS 225
+ L K++C++ L+A QK + ++LK EN+ ++ S
Sbjct: 1457 KILAEWKQKCEETHAELEASQKEARSLGTELFKIKNAYEESLDQLETLKRENKNLQQEIS 1516
Query: 226 DAT-------SKAHQLEEDIVSVTHKAIEKETELDSLKDKLKKAQHE--REQLEC-QLKT 275
D T + H+LE+ V + E + L+ + L+ + + R QLE Q+K+
Sbjct: 1517 DLTEQIAEGGKRIHELEKIKKQVEQEKCELQAALEEAEASLEHEEGKILRIQLELNQVKS 1576
Query: 276 EKDEK---------ELYKVHLKNTEIENTKLMSEVQT-------LKNLDGN---KESVIT 316
E D K +L + H++ E + L +E+++ K ++G+ E +
Sbjct: 1577 EVDRKIAEKDEEIDQLKRNHIRIVESMQSTLDAEIRSRNDAIRLKKKMEGDLNEMEIQLN 1636
Query: 317 H-----------------------------------FKEEIG----RLQLCLAEKENLQR 337
H KE++ R L AE E L+
Sbjct: 1637 HANRMAAEALRNYRNTQGILKDTQIHLDDALRSQEDLKEQLAMVERRANLLQAEIEELRA 1696
Query: 338 TFLLTTSSKEDTCFLKEQLRKAEEQVQATRQE---VVFLAKELSDAVNVRDRTMAD-LHT 393
T T S++ +++L A E+VQ + ++ K+L ++ M D L
Sbjct: 1697 TLEQTERSRK---IAEQELLDASERVQLLHTQNTSLINTKKKLETDISQMQGEMEDILQE 1753
Query: 394 ARLENEKVKKQLADAVAELKLNAMKKDQDKTDTLEH---ELRREVEDLKLRLQMAAD-HY 449
AR EK KK + DA + +KK+QD + LE + + V+DL+LRL A
Sbjct: 1754 ARNAEEKAKKAITDAA--MMAEELKKEQDTSAHLERMKKNMEQTVKDLQLRLDEAEQLAL 1811
Query: 450 KEKFKECQRLQKQINKL-----SDQSANNNNVFTKKTGNQQKVNDASVNT--DPATSAST 502
K K+ Q+L+ ++ +L S+Q N V + ++++V + + T D
Sbjct: 1812 KGGKKQIQKLEARVRELEGEVESEQKRNAEAVKGLRK-HERRVKELTYQTEEDRKNILRL 1870
Query: 503 VDVKPSPSAAEADFDIVTKGQVCEMTKEIADKTEKYNKCKQLLQDEKAKCNKYADELAKM 562
D+ A + K Q E ++ K+ K + L++ + + + ++ K+
Sbjct: 1871 QDLVDKLQAKVKSY----KRQAEEAEEQSNTNLAKFRKLQHELEEAEERADIAESQVNKL 1926
Query: 563 ELKWKE 568
+K +E
Sbjct: 1927 RVKSRE 1932
Score = 54.3 bits (129), Expect = 4e-07
Identities = 76/366 (20%), Positives = 154/366 (42%), Gaps = 50/366 (13%)
Query: 255 LKDKLKKAQHEREQLECQLKTEKDEKELYKVHLKNTEIENTKLMSEVQTLKNLDGNKESV 314
+K LK A+ E+E + + +K + EL K K E+E E +
Sbjct: 842 IKPLLKSAETEKEMATMKEEFQKIKDELAKSEAKRKELE------------------EKM 883
Query: 315 ITHFKEEIGRLQLCLAEKENLQRTFLLTTSSKEDTCFLKEQLRKAEEQVQATRQEVVFLA 374
+T KE+ AE E L + E+ C +QL K + Q++A +EV A
Sbjct: 884 VTLLKEKNDLQLQVQAEAEGL--------ADAEERC---DQLIKTKIQLEAKIKEVTERA 932
Query: 375 ---KELSDAVNVRDRTMADLHTARLENEKVKKQLADAVAELKLNAMKKDQDKTDTLEHEL 431
+E++ + + R + D E ++KK + D EL L ++K++ T+ L
Sbjct: 933 EDEEEINAELTAKKRKLED------ECSELKKDIDD--LELTLAKVEKEKHATENKVKNL 984
Query: 432 RREVEDLKLRLQMAADHYKEKFKECQRLQKQINKLSDQSANNNNVFTKKTGNQQKVNDAS 491
E+ L + A KEK + Q+ ++ L + N + K +Q+V+D
Sbjct: 985 TEEMAGLD---ETIAKLTKEKKALQEAHQQTLDDLQAEEDKVNTLTKAKIKLEQQVDDLE 1041
Query: 492 VNTDPATSASTVDVKPSPSAAEADFDIV------TKGQVCEMTKEIADKTEKYNKCKQLL 545
+ + +D++ + E D + + + ++ +++ K + + + +
Sbjct: 1042 GSLEQEKKL-RMDLERAKRKLEGDLKLAQESIMDIENEKQQLDEKLKKKEFEISNLQSKI 1100
Query: 546 QDEKAKCNKYADELAKMELKWKEQVKIAENVKLELAEVQDNYKELKRSLENPAERKMEGQ 605
+DE+A + ++ +++ + +E + E + A+ + +L R LE +ER E
Sbjct: 1101 EDEQALGIQLQKKIKELQARIEELEEEIEAERASRAKAEKQRSDLSRELEEISERLEEAG 1160
Query: 606 NSQSPQ 611
+ S Q
Sbjct: 1161 GATSAQ 1166
>gi|153792663 myosin, heavy chain 2, skeletal muscle, adult [Homo
sapiens]
Length = 1941
Score = 79.3 bits (194), Expect = 1e-14
Identities = 104/514 (20%), Positives = 222/514 (43%), Gaps = 62/514 (12%)
Query: 126 VEELLTMEDEGNSDMLVVTTKAGLLELKIEKTMKEKEELLKLIAVLEKETAQLREQVGRM 185
V E E+E N+++ T K LE + + K+ ++L +A +EKE +V +
Sbjct: 928 VTERAEDEEEINAEL---TAKKRKLEDECSELKKDIDDLELTLAKVEKEKHATENKVKNL 984
Query: 186 ERELNHEKERCDQLQAEQKGLTEVTQSLKMENEEFKKRFSDATSKAHQLEEDIVSVTHKA 245
E+ E +L E+K L E Q T Q EED V+ KA
Sbjct: 985 TEEMAGLDETIAKLTKEKKALQEAHQQ---------------TLDDLQAEEDKVNTLTKA 1029
Query: 246 -IEKETELDSLKDKLKKAQHEREQLE-CQLKTEKD-------------EKELYKVHLKNT 290
I+ E ++D L+ L++ + R LE + K E D EK+ LK
Sbjct: 1030 KIKLEQQVDDLEGSLEQEKKLRMDLERAKRKLEGDLKLAQESIMDIENEKQQLDEKLKKK 1089
Query: 291 EIENTKLMSEVQTLKNLDGNKESVITHFKEEIGRLQLCLAE-KENLQRTFLLTTSSKEDT 349
E E + L S+++ +++++ +++I LQ + E +E ++ +++
Sbjct: 1090 EFEISNLQSKIE-------DEQALGIQLQKKIKELQARIEELEEEIEAERASRAKAEKQR 1142
Query: 350 CFLKEQLRKAEEQVQ----ATRQEVVFLAKELSDAVNVRDRTMADLHTARLENE----KV 401
L +L + E+++ AT ++ K ++ +R DL A L++E +
Sbjct: 1143 SDLSRELEEISERLEEAGGATSAQIEMNKKREAEFQKMR----RDLEEATLQHEATAATL 1198
Query: 402 KKQLADAVAEL--KLNAMKKDQDKTDTLEHELRREVEDLKLRLQMAADHYKEKFKECQRL 459
+K+ AD+VAEL +++ +++ + K + + E++ E++DL ++ + K C+ L
Sbjct: 1199 RKKHADSVAELGEQIDNLQRVKQKLEKEKSEMKMEIDDLASNVETVSKAKGNLEKMCRTL 1258
Query: 460 QKQINKLSDQSANNNNVFTKKTGNQQKVNDASVNTDPATSASTVDVKPSPSAAEADFDIV 519
+ Q+++L + + T + + + T+ + +D K + + +
Sbjct: 1259 EDQLSELKSKEEEQQRLINDLTAQRGR-----LQTESGEFSRQLDEKEALVSQLSRGKQA 1313
Query: 520 TKGQVCEMTKEIADKTEKYNKCKQLLQDEKAKCNKYADELAKMELKWKEQVKIAENVKLE 579
Q+ E+ +++ ++ + N LQ + C+ ++ + + E + E
Sbjct: 1314 FTQQIEELKRQLEEEIKAKNALAHALQSSRHDCDLLREQYEEEQESKAELQRALSKANTE 1373
Query: 580 LAEVQDNYK--ELKRSLENPAERKMEGQNSQSPQ 611
+A+ + Y+ ++R+ E +K Q Q+ +
Sbjct: 1374 VAQWRTKYETDAIQRTEELEEAKKKLAQRLQAAE 1407
Score = 75.1 bits (183), Expect = 2e-13
Identities = 106/499 (21%), Positives = 218/499 (43%), Gaps = 54/499 (10%)
Query: 135 EGNSDMLVVTTKAGLLELKIEKTMKEKEELLKLIAVLEKETAQLREQVGRMERELNHEKE 194
E +M + + ++ ++ K+ +++EL + + L KE L+ QV L +E
Sbjct: 850 ETEKEMATMKEEFQKIKDELAKSEAKRKELEEKMVTLLKEKNDLQLQVQAEAEGLADAEE 909
Query: 195 RCDQL-----QAEQKGLTEVTQSLKMENEEFKKRFSDATSKAHQLEEDIVSVTHKAIEKE 249
RCDQL Q E K + EVT+ + E+EE + ++ T+K +LE++ E +
Sbjct: 910 RCDQLIKTKIQLEAK-IKEVTE--RAEDEE--EINAELTAKKRKLEDE-------CSELK 957
Query: 250 TELDSLKDKLKKAQHEREQLECQLKTEKDEKE-LYKVHLKNTEIENTKLMSEVQTLKNLD 308
++D L+ L K + E+ E ++K +E L + K T+ + + QTL +L
Sbjct: 958 KDIDDLELTLAKVEKEKHATENKVKNLTEEMAGLDETIAKLTKEKKALQEAHQQTLDDLQ 1017
Query: 309 GNKESVITHFKEEIGRLQLCLAEKENLQRTFLLTTSSKEDTCFLKEQLRKAEEQVQATRQ 368
++ V T K +I Q + +L++ L + L+ L+ A+E +
Sbjct: 1018 AEEDKVNTLTKAKIKLEQQVDDLEGSLEQEKKLRMDLERAKRKLEGDLKLAQESIMDIEN 1077
Query: 369 EVVFLAKELS----DAVNVRDRTMADLHTARLENEKVKKQLADAVAEL--KLNAMKKDQD 422
E L ++L + N++ + + D ++ +K K+L + EL ++ A + +
Sbjct: 1078 EKQQLDEKLKKKEFEISNLQSK-IEDEQALGIQLQKKIKELQARIEELEEEIEAERASRA 1136
Query: 423 KTDTLEHELRREVEDLKLRLQMAADHYKEKFKECQRLQKQINKLSDQSANNNNVFTKKTG 482
K + +L RE+E++ RL+ A + + ++ + + K+
Sbjct: 1137 KAEKQRSDLSRELEEISERLEEAGGATSAQIEMNKKREAEFQKM---------------- 1180
Query: 483 NQQKVNDASVNTDPATSASTVDVKPSPSAAEADFDIVTKGQV--------CEMTKEIADK 534
++ + +A++ + +A+T+ K + S AE I +V EM EI D
Sbjct: 1181 -RRDLEEATLQHE--ATAATLRKKHADSVAELGEQIDNLQRVKQKLEKEKSEMKMEIDDL 1237
Query: 535 TEKYNKCKQLLQDEKAKCNKYADELAKMELKWKEQVKIAENVKLELAEVQDNYKELKRSL 594
+ + + C D+L++++ K +EQ ++ ++ + +Q E R L
Sbjct: 1238 ASNVETVSKAKGNLEKMCRTLEDQLSELKSKEEEQQRLINDLTAQRGRLQTESGEFSRQL 1297
Query: 595 ENPAERKMEGQNSQSPQCF 613
+ + + Q S+ Q F
Sbjct: 1298 DE--KEALVSQLSRGKQAF 1314
Score = 60.8 bits (146), Expect = 5e-09
Identities = 125/606 (20%), Positives = 235/606 (38%), Gaps = 121/606 (19%)
Query: 74 HYVEGSTVNCVLAFQGYYLPNDDGEFYQFCYVTHKGEIRGASTPFQFRASSPVEELLTME 133
H ++ S +C L + Y + Q E+ T ++ A EEL +
Sbjct: 1337 HALQSSRHDCDLLREQYEEEQESKAELQRALSKANTEVAQWRTKYETDAIQRTEELEEAK 1396
Query: 134 DE-------GNSDMLVVTTKAGLLELKIEKTMKEKEELLKLIAVLEKETAQLREQVGRME 186
+ + V K LE ++ E E+L+ + A L ++ +
Sbjct: 1397 KKLAQRLQAAEEHVEAVNAKCASLEKTKQRLQNEVEDLMLDVERTNAACAALDKKQRNFD 1456
Query: 187 RELNHEKERCDQ----LQAEQKGLTEV-----------------TQSLKMENEEFKKRFS 225
+ L K++C++ L+A QK + ++LK EN+ ++ S
Sbjct: 1457 KILAEWKQKCEETHAELEASQKEARSLGTELFKIKNAYEESLDQLETLKRENKNLQQEIS 1516
Query: 226 DAT-------SKAHQLEEDIVSVTHKAIEKETELDSLKDKLKKAQHE--REQLEC-QLKT 275
D T + H+LE+ V + E + L+ + L+ + + R QLE Q+K+
Sbjct: 1517 DLTEQIAEGGKRIHELEKIKKQVEQEKCELQAALEEAEASLEHEEGKILRIQLELNQVKS 1576
Query: 276 EKDEK---------ELYKVHLKNTEIENTKLMSEVQT-------LKNLDGN---KESVIT 316
E D K +L + H++ E + L +E+++ K ++G+ E +
Sbjct: 1577 EVDRKIAEKDEEIDQLKRNHIRIVESMQSTLDAEIRSRNDAIRLKKKMEGDLNEMEIQLN 1636
Query: 317 H-----------------------------------FKEEIG----RLQLCLAEKENLQR 337
H KE++ R L AE E L+
Sbjct: 1637 HANRMAAEALRNYRNTQGILKDTQIHLDDALRSQEDLKEQLAMVERRANLLQAEIEELRA 1696
Query: 338 TFLLTTSSKEDTCFLKEQLRKAEEQVQATRQE---VVFLAKELSDAVNVRDRTMAD-LHT 393
T T S++ +++L A E+VQ + ++ K+L ++ M D L
Sbjct: 1697 TLEQTERSRK---IAEQELLDASERVQLLHTQNTSLINTKKKLETDISQMQGEMEDILQE 1753
Query: 394 ARLENEKVKKQLADAVAELKLNAMKKDQDKTDTLEH---ELRREVEDLKLRLQMAAD-HY 449
AR EK KK + DA + +KK+QD + LE + + V+DL+LRL A
Sbjct: 1754 ARNAEEKAKKAITDAA--MMAEELKKEQDTSAHLERMKKNMEQTVKDLQLRLDEAEQLAL 1811
Query: 450 KEKFKECQRLQKQINKL-----SDQSANNNNVFTKKTGNQQKVNDASVNT--DPATSAST 502
K K+ Q+L+ ++ +L S+Q N V + ++++V + + T D
Sbjct: 1812 KGGKKQIQKLEARVRELEGEVESEQKRNAEAVKGLRK-HERRVKELTYQTEEDRKNILRL 1870
Query: 503 VDVKPSPSAAEADFDIVTKGQVCEMTKEIADKTEKYNKCKQLLQDEKAKCNKYADELAKM 562
D+ A + K Q E ++ K+ K + L++ + + + ++ K+
Sbjct: 1871 QDLVDKLQAKVKSY----KRQAEEAEEQSNTNLAKFRKLQHELEEAEERADIAESQVNKL 1926
Query: 563 ELKWKE 568
+K +E
Sbjct: 1927 RVKSRE 1932
Score = 54.3 bits (129), Expect = 4e-07
Identities = 76/366 (20%), Positives = 154/366 (42%), Gaps = 50/366 (13%)
Query: 255 LKDKLKKAQHEREQLECQLKTEKDEKELYKVHLKNTEIENTKLMSEVQTLKNLDGNKESV 314
+K LK A+ E+E + + +K + EL K K E+E E +
Sbjct: 842 IKPLLKSAETEKEMATMKEEFQKIKDELAKSEAKRKELE------------------EKM 883
Query: 315 ITHFKEEIGRLQLCLAEKENLQRTFLLTTSSKEDTCFLKEQLRKAEEQVQATRQEVVFLA 374
+T KE+ AE E L + E+ C +QL K + Q++A +EV A
Sbjct: 884 VTLLKEKNDLQLQVQAEAEGL--------ADAEERC---DQLIKTKIQLEAKIKEVTERA 932
Query: 375 ---KELSDAVNVRDRTMADLHTARLENEKVKKQLADAVAELKLNAMKKDQDKTDTLEHEL 431
+E++ + + R + D E ++KK + D EL L ++K++ T+ L
Sbjct: 933 EDEEEINAELTAKKRKLED------ECSELKKDIDD--LELTLAKVEKEKHATENKVKNL 984
Query: 432 RREVEDLKLRLQMAADHYKEKFKECQRLQKQINKLSDQSANNNNVFTKKTGNQQKVNDAS 491
E+ L + A KEK + Q+ ++ L + N + K +Q+V+D
Sbjct: 985 TEEMAGLD---ETIAKLTKEKKALQEAHQQTLDDLQAEEDKVNTLTKAKIKLEQQVDDLE 1041
Query: 492 VNTDPATSASTVDVKPSPSAAEADFDIV------TKGQVCEMTKEIADKTEKYNKCKQLL 545
+ + +D++ + E D + + + ++ +++ K + + + +
Sbjct: 1042 GSLEQEKKL-RMDLERAKRKLEGDLKLAQESIMDIENEKQQLDEKLKKKEFEISNLQSKI 1100
Query: 546 QDEKAKCNKYADELAKMELKWKEQVKIAENVKLELAEVQDNYKELKRSLENPAERKMEGQ 605
+DE+A + ++ +++ + +E + E + A+ + +L R LE +ER E
Sbjct: 1101 EDEQALGIQLQKKIKELQARIEELEEEIEAERASRAKAEKQRSDLSRELEEISERLEEAG 1160
Query: 606 NSQSPQ 611
+ S Q
Sbjct: 1161 GATSAQ 1166
>gi|115527082 myosin, heavy chain 1, skeletal muscle, adult [Homo
sapiens]
Length = 1939
Score = 78.6 bits (192), Expect = 2e-14
Identities = 115/505 (22%), Positives = 224/505 (44%), Gaps = 83/505 (16%)
Query: 150 LELKIEKTMKEKEELLKLIAVLEKETAQLREQVGRMERE----LNHEKERCDQLQAEQKG 205
LEL + K KEK + L +E A L E + ++ +E ++ D LQAE+
Sbjct: 961 LELTLAKVEKEKHATENKVKNLTEEMAGLDETIAKLTKEKKALQEAHQQTLDDLQAEEDK 1020
Query: 206 LTEVTQS-LKMEN---------EEFKKRFSDATSKAHQLEEDIVSVTHKAIEKETELDSL 255
+ +T++ +K+E E+ KK D +LE D+ ++ E + L
Sbjct: 1021 VNTLTKAKIKLEQQVDDLEGSLEQEKKIRMDLERAKRKLEGDLKLAQESTMDIENDKQQL 1080
Query: 256 KDKLKKAQHEREQLECQLKTEKDEKELYKVHLKNTEIENTKLMSEVQTLKNLDGNKESVI 315
+KLKK + E L+ ++ +DE+ L +L +++ L ++ I
Sbjct: 1081 DEKLKKKEFEMSGLQSKI---EDEQAL-----------GMQLQKKIKEL-------QARI 1119
Query: 316 THFKEEIGRLQLCLAEKENLQRTFLLTTSSKEDTCFLKEQLRKAEEQVQATRQEVVFLAK 375
+EEI + A+ E QR+ L S+E L+E + EE AT ++ K
Sbjct: 1120 EELEEEIEAERASRAKAEK-QRSDL----SRE----LEEISERLEEAGGATSAQIEMNKK 1170
Query: 376 ELSDAVNVRDRTMADLHTARLENE----KVKKQLADAVAEL--KLNAMKKDQDKTDTLEH 429
++ +R DL A L++E ++K+ AD+VAEL +++ +++ + K + +
Sbjct: 1171 REAEFQKMR----RDLEEATLQHEATAATLRKKHADSVAELGEQIDNLQRVKQKLEKEKS 1226
Query: 430 ELRREVEDLKLRLQMAADHYKEKFKECQRLQKQINKLSDQSANNNNVFTKKTGNQQKVND 489
E++ E++DL ++ + K C+ L+ Q++++ TK+ Q+ +ND
Sbjct: 1227 EMKMEIDDLASNMETVSKAKGNLEKMCRALEDQLSEIK----------TKEEEQQRLIND 1276
Query: 490 -----ASVNTDPATSASTVDVKPSPSAAEADFDIVTKGQVCEMTKEIADKTEKYNKCKQL 544
A + T+ + +D K + + + Q+ E+ +++ ++ + +
Sbjct: 1277 LTAQRARLQTESGEYSRQLDEKDTLVSQLSRGKQAFTQQIEELKRQLEEEIKAKSALAHA 1336
Query: 545 LQDEKAKCN----KYADEL-AKMELK---WKEQVKIAE-NVKLELAEVQ--DNYKELKRS 593
LQ + C+ +Y +E AK EL+ K ++A+ K E +Q + +E K+
Sbjct: 1337 LQSSRHDCDLLREQYEEEQEAKAELQRAMSKANSEVAQWRTKYETDAIQRTEELEEAKKK 1396
Query: 594 LE---NPAERKMEGQNSQSPQCFKT 615
L AE +E N++ KT
Sbjct: 1397 LAQRLQDAEEHVEAVNAKCASLEKT 1421
Score = 73.2 bits (178), Expect = 9e-13
Identities = 101/484 (20%), Positives = 210/484 (43%), Gaps = 60/484 (12%)
Query: 153 KIEKTMKEKEELLKLIAVLEKETAQLREQVGRMERELNHEKERCDQL-----QAEQKGLT 207
++ KT +++EL + + L +E L+ QV L +ERCDQL Q E K +
Sbjct: 866 ELAKTEAKRKELEEKMVTLMQEKNDLQLQVQAEADSLADAEERCDQLIKTKIQLEAK-IK 924
Query: 208 EVTQSLKMENEEFKKRFSDATSKAHQLEEDIVSVTHKAIEKETELDSLKDKLKKAQHERE 267
EVT+ + E+EE + ++ T+K +LE++ E + ++D L+ L K + E+
Sbjct: 925 EVTE--RAEDEE--EINAELTAKKRKLEDE-------CSELKKDIDDLELTLAKVEKEKH 973
Query: 268 QLECQLKTEKDEKE-LYKVHLKNTEIENTKLMSEVQTLKNLDGNKESVITHFKEEIGRLQ 326
E ++K +E L + K T+ + + QTL +L ++ V T K +I Q
Sbjct: 974 ATENKVKNLTEEMAGLDETIAKLTKEKKALQEAHQQTLDDLQAEEDKVNTLTKAKIKLEQ 1033
Query: 327 LCLAEKENLQRTFLLTTSSKEDTCFLKEQLRKAEEQVQATRQEVVFLAKELSDAVNVRDR 386
+ ++L+ + + D K +L + Q + ++ ++L + + ++
Sbjct: 1034 ----QVDDLEGSLEQEKKIRMDLERAKRKLEGDLKLAQESTMDIENDKQQLDEKLKKKEF 1089
Query: 387 TMADLHTARLENEKVKKQLADAVAEL---------KLNAMKKDQDKTDTLEHELRREVED 437
M+ L + + + + QL + EL ++ A + + K + +L RE+E+
Sbjct: 1090 EMSGLQSKIEDEQALGMQLQKKIKELQARIEELEEEIEAERASRAKAEKQRSDLSRELEE 1149
Query: 438 LKLRLQMAADHYKEKFKECQRLQKQINKLSDQSANNNNVFTKKTGNQQKVNDASVNTDPA 497
+ RL+ A + + ++ + + K+ ++ + +A++ +
Sbjct: 1150 ISERLEEAGGATSAQIEMNKKREAEFQKM-----------------RRDLEEATLQHE-- 1190
Query: 498 TSASTVDVKPSPSAAEADFDIVTKGQV--------CEMTKEIADKTEKYNKCKQLLQDEK 549
+A+T+ K + S AE I +V EM EI D + + +
Sbjct: 1191 ATAATLRKKHADSVAELGEQIDNLQRVKQKLEKEKSEMKMEIDDLASNMETVSKAKGNLE 1250
Query: 550 AKCNKYADELAKMELKWKEQVKIAENVKLELAEVQDNYKELKRSLENPAERKMEGQNSQS 609
C D+L++++ K +EQ ++ ++ + A +Q E R L+ + + Q S+
Sbjct: 1251 KMCRALEDQLSEIKTKEEEQQRLINDLTAQRARLQTESGEYSRQLDE--KDTLVSQLSRG 1308
Query: 610 PQCF 613
Q F
Sbjct: 1309 KQAF 1312
Score = 72.8 bits (177), Expect = 1e-12
Identities = 91/465 (19%), Positives = 202/465 (43%), Gaps = 39/465 (8%)
Query: 150 LELKIEKTMKEKEELLKLIAVLEKETAQLREQVGRMERELNHEKERCDQLQAEQKGLTEV 209
LE ++ + ++EE +LI L + A+L+ + G R+L+ + QL ++ T+
Sbjct: 1256 LEDQLSEIKTKEEEQQRLINDLTAQRARLQTESGEYSRQLDEKDTLVSQLSRGKQAFTQQ 1315
Query: 210 TQSLKMENEEFKKRFSDATSKAHQLEEDIVSVTHKAIEKETELDS-LKDKLKKAQHEREQ 268
+ LK + EE K S A + A Q + + E+E E + L+ + KA E Q
Sbjct: 1316 IEELKRQLEEEIKAKS-ALAHALQSSRHDCDLLREQYEEEQEAKAELQRAMSKANSEVAQ 1374
Query: 269 LECQLKTE----KDEKELYKVHL--------KNTEIENTKLMSEVQTLKNLDGNKESVIT 316
+ +T+ +E E K L ++ E N K S +T + L E ++
Sbjct: 1375 WRTKYETDAIQRTEELEEAKKKLAQRLQDAEEHVEAVNAKCASLEKTKQRLQNEVEDLMI 1434
Query: 317 HFKEEIGRLQLCLAEKENLQRTFLLTTSSKEDTCFLKEQLRKAEEQVQATRQEVVFLAKE 376
++ R A + QR F + + C + +++A+++E L+ E
Sbjct: 1435 ----DVERTNAACAALDKKQRNFDKILAEWKQKC------EETHAELEASQKESRSLSTE 1484
Query: 377 LSDAVNVRDRTMADLHTARLENEKVKKQLADAVAELKLNAMKKDQDKTDTLEHELRREVE 436
L N + ++ L T + EN+ ++++++D ++ K + + ++ ++ +E
Sbjct: 1485 LFKIKNAYEESLDQLETLKRENKNLQQEISDLTEQIAEGG--KRIHELEKIKKQVEQEKS 1542
Query: 437 DLKLRLQMAADHYKEKFKECQRLQKQINKLSDQ----SANNNNVFTKKTGNQQKVNDASV 492
+L+ L+ A + + + R+Q ++N++ + A + + N ++ ++
Sbjct: 1543 ELQAALEEAEASLEHEEGKILRIQLELNQVKSEVDRKIAEKDEEIDQMKRNHIRIVESMQ 1602
Query: 493 NTDPATSASTVDVKPSPSAAEADFDIVTKGQVCEMTKEIADKTEKYNKCKQLLQDEKAKC 552
+T A S D E D + + + Q+ + A+ Y + +L+D +
Sbjct: 1603 STLDAEIRSRNDAIRLKKKMEGDLNEM-EIQLNHANRMAAEALRNYRNTQAILKDTQL-- 1659
Query: 553 NKYADELAKMELKWKEQVKIAEN----VKLELAEVQDNYKELKRS 593
+ D+ + + KEQ+ + E ++ E+ E++ ++ +RS
Sbjct: 1660 --HLDDALRSQEDLKEQLAMVERRANLLQAEIEELRATLEQTERS 1702
Score = 59.7 bits (143), Expect = 1e-08
Identities = 101/549 (18%), Positives = 205/549 (37%), Gaps = 63/549 (11%)
Query: 74 HYVEGSTVNCVLAFQGYYLPNDDGEFYQFCYVTHKGEIRGASTPFQFRASSPVEELLTME 133
H ++ S +C L + Y + Q E+ T ++ A EEL +
Sbjct: 1335 HALQSSRHDCDLLREQYEEEQEAKAELQRAMSKANSEVAQWRTKYETDAIQRTEELEEAK 1394
Query: 134 -------DEGNSDMLVVTTKAGLLELKIEKTMKEKEELLKLIAVLEKETAQLREQVGRME 186
+ + V K LE ++ E E+L+ + A L ++ +
Sbjct: 1395 KKLAQRLQDAEEHVEAVNAKCASLEKTKQRLQNEVEDLMIDVERTNAACAALDKKQRNFD 1454
Query: 187 RELNHEKERCDQLQAEQKGLTEVTQSLKMENEEFKKRFSDATSKAH-------QLEEDIV 239
+ L K++C++ AE + + ++SL E + K + ++ + L+++I
Sbjct: 1455 KILAEWKQKCEETHAELEASQKESRSLSTELFKIKNAYEESLDQLETLKRENKNLQQEIS 1514
Query: 240 SVTHKAIEKETELDSLKDKLKKAQHEREQLECQLKTEKDEKELYKVHLKNTEIENTKLMS 299
+T + E + L +K+KK Q E+E+ E Q E+ E L E E K++
Sbjct: 1515 DLTEQIAEGGKRIHEL-EKIKK-QVEQEKSELQAALEEAEASL--------EHEEGKILR 1564
Query: 300 EVQTLKNLDGNKESVITHFKEEIGRLQL-CLAEKENLQRTFLLTTSSKEDTCFLKEQ--- 355
L + + I EEI +++ + E++Q T S+ D LK++
Sbjct: 1565 IQLELNQVKSEVDRKIAEKDEEIDQMKRNHIRIVESMQSTLDAEIRSRNDAIRLKKKMEG 1624
Query: 356 -LRKAEEQVQATRQEVVFLAKELSDAVNVRDRTMADLHTARLENEKVKKQLADAVAELKL 414
L + E Q+ + + + + T L A E +K+QL A+ E +
Sbjct: 1625 DLNEMEIQLNHANRMAAEALRNYRNTQAILKDTQLHLDDALRSQEDLKEQL--AMVERRA 1682
Query: 415 NAMKKDQDKTDTLEHELRREVEDLKLRLQMAADHYKEKFKECQRLQKQINKLSDQSANNN 474
N ++ + + ELR +E + ++A + + Q L Q L +
Sbjct: 1683 NLLQAEIE-------ELRATLEQTERSRKIAEQELLDASERVQLLHTQNTSLINTKKKLE 1735
Query: 475 NVFTKKTGNQQKVNDASVNTDPATSASTVDVKPSPSAAEADFDIVTKGQVCEMTKEIADK 534
++ G + + + N + + D + E K+ D
Sbjct: 1736 TDISQIQGEMEDIIQEARNAEEKAKKAITDA----------------AMMAEELKKEQDT 1779
Query: 535 TEKYNKCKQLLQDEKAKCNKYADELAKMELKWKEQVKIAENVKLELAEVQDNYKELKRSL 594
+ + K+ L+ DE ++ LK K ++ +++ +EL+ +
Sbjct: 1780 SAHLERMKKNLEQTVKDLQHRLDEAEQLALK---------GGKKQIQKLEARVRELEGEV 1830
Query: 595 ENPAERKME 603
E+ +R +E
Sbjct: 1831 ESEQKRNVE 1839
Score = 57.8 bits (138), Expect = 4e-08
Identities = 92/466 (19%), Positives = 206/466 (44%), Gaps = 58/466 (12%)
Query: 212 SLKMENEEFKKRFSDATSKAHQLEEDIVSVTHK----AIEKETELDSLKDKLKKAQH--- 264
++K E E+ K+ + +K +LEE +V++ + ++ + E DSL D ++
Sbjct: 855 NMKEEFEKTKEELAKTEAKRKELEEKMVTLMQEKNDLQLQVQAEADSLADAEERCDQLIK 914
Query: 265 EREQLECQLK--TEK--DEKELYKVHLKNTEI--ENTKLMSEVQTLKNLDGNKESVITHF 318
+ QLE ++K TE+ DE+E+ N E+ + KL E LK + E +
Sbjct: 915 TKIQLEAKIKEVTERAEDEEEI------NAELTAKKRKLEDECSELKKDIDDLELTLAKV 968
Query: 319 KEE----IGRLQLCLAEKENLQRTFLLTTSSKEDTCFLKEQLRKAEEQVQATRQEVVFLA 374
++E +++ E L T T K+ L+E ++ + +QA +V L
Sbjct: 969 EKEKHATENKVKNLTEEMAGLDETIAKLTKEKK---ALQEAHQQTLDDLQAEEDKVNTLT 1025
Query: 375 K---ELSDAVNVRDRTMADLHTARLENEKVKKQLADAVAELKLNAMKKDQDKTDTLEHEL 431
K +L V+ + ++ R++ E+ K++L + + + M + DK E
Sbjct: 1026 KAKIKLEQQVDDLEGSLEQEKKIRMDLERAKRKLEGDLKLAQESTMDIENDKQQLDEKLK 1085
Query: 432 RREVEDLKLRLQMAAD-----HYKEKFKECQ-RLQKQINKLSDQSANNNNVFTKKTGNQQ 485
++E E L+ ++ + ++K KE Q R+++ ++ + A+ +++ +
Sbjct: 1086 KKEFEMSGLQSKIEDEQALGMQLQKKIKELQARIEELEEEIEAERASRAKAEKQRSDLSR 1145
Query: 486 KVNDASVNTDPATSASTVDVKPSPSAAEADFD-----------------IVTKGQVCEMT 528
++ + S + A A++ ++ + EA+F + + +
Sbjct: 1146 ELEEISERLEEAGGATSAQIEMN-KKREAEFQKMRRDLEEATLQHEATAATLRKKHADSV 1204
Query: 529 KEIADKTEKYNKCKQLLQDEKAKCNKYADELA-KMELKWKEQ---VKIAENVKLELAEVQ 584
E+ ++ + + KQ L+ EK++ D+LA ME K + K+ ++ +L+E++
Sbjct: 1205 AELGEQIDNLQRVKQKLEKEKSEMKMEIDDLASNMETVSKAKGNLEKMCRALEDQLSEIK 1264
Query: 585 DNYKELKRSLENPAERKMEGQNSQSPQCFKTCSEQNGYVLTLSNAQ 630
+E +R + + ++ Q ++S + + E++ V LS +
Sbjct: 1265 TKEEEQQRLINDLTAQRARLQ-TESGEYSRQLDEKDTLVSQLSRGK 1309
Score = 55.5 bits (132), Expect = 2e-07
Identities = 75/366 (20%), Positives = 156/366 (42%), Gaps = 50/366 (13%)
Query: 255 LKDKLKKAQHEREQLECQLKTEKDEKELYKVHLKNTEIENTKLMSEVQTLKNLDGNKESV 314
+K LK A+ E+E + + EK ++EL K K E+E E +
Sbjct: 840 IKPLLKSAETEKEMANMKEEFEKTKEELAKTEAKRKELE------------------EKM 881
Query: 315 ITHFKEEIGRLQLCLAEKENLQRTFLLTTSSKEDTCFLKEQLRKAEEQVQATRQEVVFLA 374
+T +E+ AE ++L + E+ C +QL K + Q++A +EV A
Sbjct: 882 VTLMQEKNDLQLQVQAEADSL--------ADAEERC---DQLIKTKIQLEAKIKEVTERA 930
Query: 375 ---KELSDAVNVRDRTMADLHTARLENEKVKKQLADAVAELKLNAMKKDQDKTDTLEHEL 431
+E++ + + R + D E ++KK + D EL L ++K++ T+ L
Sbjct: 931 EDEEEINAELTAKKRKLED------ECSELKKDIDD--LELTLAKVEKEKHATENKVKNL 982
Query: 432 RREVEDLKLRLQMAADHYKEKFKECQRLQKQINKLSDQSANNNNVFTKKTGNQQKVNDAS 491
E+ L + A KEK + Q+ ++ L + N + K +Q+V+D
Sbjct: 983 TEEMAGLD---ETIAKLTKEKKALQEAHQQTLDDLQAEEDKVNTLTKAKIKLEQQVDDLE 1039
Query: 492 VNTDPATSASTVDVKPSPSAAEADFDIVTKGQV------CEMTKEIADKTEKYNKCKQLL 545
+ + +D++ + E D + + + ++ +++ K + + + +
Sbjct: 1040 GSLEQEKKI-RMDLERAKRKLEGDLKLAQESTMDIENDKQQLDEKLKKKEFEMSGLQSKI 1098
Query: 546 QDEKAKCNKYADELAKMELKWKEQVKIAENVKLELAEVQDNYKELKRSLENPAERKMEGQ 605
+DE+A + ++ +++ + +E + E + A+ + +L R LE +ER E
Sbjct: 1099 EDEQALGMQLQKKIKELQARIEELEEEIEAERASRAKAEKQRSDLSRELEEISERLEEAG 1158
Query: 606 NSQSPQ 611
+ S Q
Sbjct: 1159 GATSAQ 1164
Score = 45.1 bits (105), Expect = 3e-04
Identities = 33/130 (25%), Positives = 65/130 (50%), Gaps = 7/130 (5%)
Query: 171 LEKETAQLREQVGRMERELNHEKERCDQLQAEQKGLTEVTQSLKMENEEFKKRFSDATSK 230
++K A++RE G +E E E L+ ++ + E+T + EE +K
Sbjct: 1816 IQKLEARVRELEGEVESEQKRNVEAVKGLRKHERKVKELT----YQTEEDRKNILRLQDL 1871
Query: 231 AHQLEEDIVSVTHKAIEKETELDSLKDKLKKAQHEREQLECQLKTEKDEKELYKVHLKNT 290
+L+ + S +A E E + + K ++ QHE E E + + + E ++ K+ +K+
Sbjct: 1872 VDKLQAKVKSYKRQAEEAEEQSNVNLSKFRRIQHELE--EAEERADIAESQVNKLRVKSR 1929
Query: 291 EIENTKLMSE 300
E+ +TK++SE
Sbjct: 1930 EV-HTKIISE 1938
Score = 35.4 bits (80), Expect = 0.21
Identities = 34/180 (18%), Positives = 76/180 (42%), Gaps = 12/180 (6%)
Query: 150 LELKIEKTMKEKEELLKLIAVLEKETAQLREQVGRMERELNHEKERCDQLQAEQKGLTEV 209
LE I + E E++++ E++ + M EL E++ L+ +K L +
Sbjct: 1734 LETDISQIQGEMEDIIQEARNAEEKAKKAITDAAMMAEELKKEQDTSAHLERMKKNLEQT 1793
Query: 210 TQSLKMENEEF--------KKRFSDATSKAHQLEEDIVSVTHKAIEKETELDSLKDKLKK 261
+ L+ +E KK+ ++ +LE ++ S + +E L + K+K+
Sbjct: 1794 VKDLQHRLDEAEQLALKGGKKQIQKLEARVRELEGEVESEQKRNVEAVKGLRKHERKVKE 1853
Query: 262 AQHEREQLECQLKTEKDEKELYKVHLKNTEIENTKLMSEVQTLKNLDGNKESVITHFKEE 321
++ E+ + +D + + +K+ + + E + N++ +K I H EE
Sbjct: 1854 LTYQTEEDRKNILRLQDLVDKLQAKVKSYK----RQAEEAEEQSNVNLSKFRRIQHELEE 1909
Score = 30.0 bits (66), Expect = 8.7
Identities = 26/128 (20%), Positives = 59/128 (46%), Gaps = 14/128 (10%)
Query: 150 LELKIEKTMKEKEELLKLIAVLEKETAQLREQVGRMERELNHEKERCDQLQAEQKGLTEV 209
LE ++E K E +K + E++ +L Q + + ++ D+LQA+ K
Sbjct: 1826 LEGEVESEQKRNVEAVKGLRKHERKVKELTYQTEEDRKNILRLQDLVDKLQAKVK----- 1880
Query: 210 TQSLKMENEEFKKRFSDATSKAHQLEEDIVSVTHKAIEKETELDSLKDKLKKAQHEREQL 269
S K + EE +++ + SK +++ H+ E E D + ++ K + + ++
Sbjct: 1881 --SYKRQAEEAEEQSNVNLSKFRRIQ-------HELEEAEERADIAESQVNKLRVKSREV 1931
Query: 270 ECQLKTEK 277
++ +E+
Sbjct: 1932 HTKIISEE 1939
>gi|156104908 myosin heavy chain 6 [Homo sapiens]
Length = 1939
Score = 78.6 bits (192), Expect = 2e-14
Identities = 105/492 (21%), Positives = 213/492 (43%), Gaps = 34/492 (6%)
Query: 135 EGNSDMLVVTTKAGLLELKIEKTMKEKEELLKLIAVLEKETAQLREQVGRMERELNHEKE 194
E +M + + G ++ +EK+ ++EL + + L +E L+ QV + LN +E
Sbjct: 846 ETEKEMATMKEEFGRIKETLEKSEARRKELEEKMVSLLQEKNDLQLQVQAEQDNLNDAEE 905
Query: 195 RCD-------QLQAEQKGLTEVTQSLKMENEEFKKRFSDATSKAHQLEEDIVSVTHKAIE 247
RCD QL+A+ K + E + + N E + + +L++DI + +
Sbjct: 906 RCDQLIKNKIQLEAKVKEMNERLEDEEEMNAELTAKKRKLEDECSELKKDIDDLELTLAK 965
Query: 248 KETELDSLKDKLKKAQHEREQL-ECQLKTEKDEKELYKVH---LKNTEIENTKLMSEVQT 303
E E + ++K+K E L E K K++K L + H L + ++E K+ S ++
Sbjct: 966 VEKEKHATENKVKNLTEEMAGLDEIIAKLTKEKKALQEAHQQALDDLQVEEDKVNSLSKS 1025
Query: 304 LKNLDGNKESVITHFKEEIGRLQLCLAEKENLQRTFLLTTSS----KEDTCFLKEQLRKA 359
L+ + + ++E K L+ LT S + D L+E+L+K
Sbjct: 1026 KVKLEQQVDDLEGSLEQEKKVRMDLERAKRKLEGDLKLTQESIMDLENDKLQLEEKLKKK 1085
Query: 360 E---EQVQATRQEVVFLAKELSDAVNVRDRTMADL-------HTARLENEKVKKQLADAV 409
E Q + ++ LA +L + + +L TAR + EK++ L+ +
Sbjct: 1086 EFDINQQNSKIEDEQVLALQLQKKLKENQARIEELEEELEAERTARAKVEKLRSDLSREL 1145
Query: 410 AELKLNAMKKDQDKTDTLEHELRREVEDLKLRLQMAADHYKEKFKECQRLQKQINKLSDQ 469
E+ + + +E +RE E K+R + + + +K + +++
Sbjct: 1146 EEISERLEEAGGATSVQIEMNKKREAEFQKMRRDLEEATLQHEATAAALRKKHADSVAEL 1205
Query: 470 SANNNNVFTKKTGNQQKVNDASVNTDPATSASTVDVKPSPSAAEADFDIVTKGQVCEMTK 529
+N+ K +++ ++ + D TS +K A+A+ + V++ + +
Sbjct: 1206 GEQIDNLQRVKQKLEKEKSEFKLELDDVTSNMEQIIK-----AKANLEKVSR-TLEDQAN 1259
Query: 530 EIADKTEKYNKCKQLLQDEKAKCNKYADELAKMELKWKEQVKIAENVKLELAEVQDNYKE 589
E K E+ + ++AK ELA+ +L+ KE + I++ + +L+ Q ++
Sbjct: 1260 EYRVKLEEAQRSLNDFTTQRAKLQTENGELAR-QLEEKEAL-ISQLTRGKLSYTQ-QMED 1316
Query: 590 LKRSLENPAERK 601
LKR LE + K
Sbjct: 1317 LKRQLEEEGKAK 1328
Score = 72.4 bits (176), Expect = 2e-12
Identities = 98/478 (20%), Positives = 200/478 (41%), Gaps = 42/478 (8%)
Query: 151 ELKIEKTMKEKEELLK--LIAVLEKETAQLREQVGRMERELNHEKERCDQLQAEQKGLTE 208
EL+ E+T + K E L+ L LE+ + +L E G ++ K+R + Q ++ L E
Sbjct: 1123 ELEAERTARAKVEKLRSDLSRELEEISERLEEAGGATSVQIEMNKKREAEFQKMRRDLEE 1182
Query: 209 VTQSLKMENEEFKKRFSDATSKAHQLEEDIVSVTHKAIEKET-----ELDSLKDKLKKAQ 263
T + +K+ +D+ ++ + +++ V K +EKE ELD + +++
Sbjct: 1183 ATLQHEATAAALRKKHADSVAELGEQIDNLQRVKQK-LEKEKSEFKLELDDVTSNMEQII 1241
Query: 264 HEREQLECQLKTEKDEKELYKVHLKNTE-------IENTKLMSEVQTLKNLDGNKESVIT 316
+ LE +T +D+ Y+V L+ + + KL +E L KE++I+
Sbjct: 1242 KAKANLEKVSRTLEDQANEYRVKLEEAQRSLNDFTTQRAKLQTENGELARQLEEKEALIS 1301
Query: 317 H-------FKEEIGRLQLCLAEKENLQRTFLLTTSSKEDTCFLKEQLRKAEEQVQATRQE 369
+ +++ L+ L E+ + S C L + + E + +A Q
Sbjct: 1302 QLTRGKLSYTQQMEDLKRQLEEEGKAKNALAHALQSARHDCDLLREQYEEETEAKAELQR 1361
Query: 370 VVFLAKELSDAVNVRDRTMADLHTARLENEKVKKQLADAV--AELKLNAMKKDQDKTDTL 427
V L+K S+ R + D E E+ KK+LA + AE + A+ +
Sbjct: 1362 V--LSKANSEVAQWRTKYETDAIQRTEELEEAKKKLAQRLQDAEEAVEAVNAKCSSLEKT 1419
Query: 428 EHELRREVEDLKLRLQMAADHYKEKFKECQRLQKQINKLSDQSANNNNVFTK-KTGNQQK 486
+H L+ E+EDL + + +R L + N + + + K ++
Sbjct: 1420 KHRLQNEIEDLMV--------------DVERSNAAAAALDKKQRNFDKILAEWKQKYEES 1465
Query: 487 VNDASVNTDPATSASTVDVKPSPSAAEADFDIVT-KGQVCEMTKEIADKTEKYNKCKQLL 545
++ + A S ST K + E+ + T K + + +EI+D TE+ + + +
Sbjct: 1466 QSELESSQKEARSLSTELFKLKNAYEESLEHLETFKRENKNLQEEISDLTEQLGEGGKNV 1525
Query: 546 QDEKAKCNKYADELAKMELKWKEQVKIAENVKLELAEVQDNYKELKRSLENPAERKME 603
+ + + E +++ +E E+ + ++ Q + ++K +E K E
Sbjct: 1526 HELEKVRKQLEVEKLELQSALEEAEASLEHEEGKILRAQLEFNQIKAEIERKLAEKDE 1583
Score = 70.1 bits (170), Expect = 8e-12
Identities = 89/456 (19%), Positives = 203/456 (44%), Gaps = 56/456 (12%)
Query: 169 AVLEKETAQLREQVGRMERELNHEKERCDQLQAEQKGLTEVTQSLKMENEEFKKRFSDAT 228
A EKE A ++E+ GR++ L + R +L+ + L + L+++ + + +DA
Sbjct: 845 AETEKEMATMKEEFGRIKETLEKSEARRKELEEKMVSLLQEKNDLQLQVQAEQDNLNDAE 904
Query: 229 SKAHQLEEDIVSVTHKAIEKETELDSLKDKLKKAQHEREQLECQLKTEKDEKELYKVHLK 288
+ QL ++ I+ E ++ + ++L+ + +L + + +DE K +
Sbjct: 905 ERCDQLIKN-------KIQLEAKVKEMNERLEDEEEMNAELTAKKRKLEDECSELKKDID 957
Query: 289 NTEIENTKLMSEVQTLKNLDGNKESVITHFKEEIGRLQLCLAEKENLQRTFLLTTSSKED 348
+ E+ K+ E +N + + EE+ L +A+ LT K
Sbjct: 958 DLELTLAKVEKEKHATEN-------KVKNLTEEMAGLDEIIAK---------LTKEKKA- 1000
Query: 349 TCFLKEQLRKAEEQVQATRQEVVFLAK---ELSDAVNVRDRTMADLHTARLENEKVKKQL 405
L+E ++A + +Q +V L+K +L V+ + ++ R++ E+ K++L
Sbjct: 1001 ---LQEAHQQALDDLQVEEDKVNSLSKSKVKLEQQVDDLEGSLEQEKKVRMDLERAKRKL 1057
Query: 406 ADAVAELKLNAMKKDQDKTDTLEHELRREVEDLKLR------LQMAADHYKEKFKECQ-R 458
+ + + M + DK LE +L+++ D+ + Q+ A ++K KE Q R
Sbjct: 1058 EGDLKLTQESIMDLENDKLQ-LEEKLKKKEFDINQQNSKIEDEQVLALQLQKKLKENQAR 1116
Query: 459 LQKQINKLSDQSANNNNVFTKKTGNQQKVNDASVNTDPATSASTVDVKPSPSAAEADFDI 518
+++ +L + V ++ +++ + S + A A++V ++ + EA+F
Sbjct: 1117 IEELEEELEAERTARAKVEKLRSDLSRELEEISERLEEAGGATSVQIEMN-KKREAEFQ- 1174
Query: 519 VTKGQVCEMTKEIADKTEKYNKCKQLLQ----DEKAKCNKYADELAKMELKWKEQVKIAE 574
+M +++ + T ++ L+ D A+ + D L +++ K +++
Sbjct: 1175 -------KMRRDLEEATLQHEATAAALRKKHADSVAELGEQIDNLQRVKQKLEKE---KS 1224
Query: 575 NVKLELAEVQDNYKELKRSLEN--PAERKMEGQNSQ 608
KLEL +V N +++ ++ N R +E Q ++
Sbjct: 1225 EFKLELDDVTSNMEQIIKAKANLEKVSRTLEDQANE 1260
Score = 60.8 bits (146), Expect = 5e-09
Identities = 83/408 (20%), Positives = 169/408 (41%), Gaps = 61/408 (14%)
Query: 121 RASSPVEELLTMEDEGNSDMLVVTTKAGLLELKIEKTMKEKEELLKLIAVLEKETAQLRE 180
R + +E+L+ + N+ + K + + + ++ EE + +KE L
Sbjct: 1422 RLQNEIEDLMVDVERSNAAAAALDKKQRNFDKILAEWKQKYEESQSELESSQKEARSLST 1481
Query: 181 QVGRMERELNHEKERCDQLQAEQKGLTEVTQSLKMENEEFKKRFSDATSKAHQLEEDIVS 240
++ +++ E + + E K L E L + E K + QLE + +
Sbjct: 1482 ELFKLKNAYEESLEHLETFKRENKNLQEEISDLTEQLGEGGKNVHELEKVRKQLEVEKLE 1541
Query: 241 VTHKAIEKETELDSLKDKLKKAQHEREQLECQLK---TEKDE--KELYKVHLKNTEIENT 295
+ E E L+ + K+ +AQ E Q++ +++ EKDE ++ + H + + T
Sbjct: 1542 LQSALEEAEASLEHEEGKILRAQLEFNQIKAEIERKLAEKDEEMEQAKRNHQRVVDSLQT 1601
Query: 296 KLMSE-------VQTLKNLDGN---KESVITH-------FKEEIGRLQLCLAE------- 331
L +E ++ K ++G+ E ++H ++++ LQ L +
Sbjct: 1602 SLDAETRSRNEVLRVKKKMEGDLNEMEIQLSHANRMAAEAQKQVKSLQSLLKDTQIQLDD 1661
Query: 332 --------KENL----QRTFLLTTSSKEDTCFLKEQLRK---AEEQVQATRQEVVFLAKE 376
KEN+ +R LL +E +++ R AE+++ T + V L +
Sbjct: 1662 AVRANDDLKENIAIVERRNNLLQAELEELRAVVEQTERSRKLAEQELIETSERVQLLHSQ 1721
Query: 377 LSDAVNVRDRTMADL-----------HTARLENEKVKKQLADAVAELKLNAMKKDQDKTD 425
+ +N + + +DL R EK KK + DA + +KK+QD +
Sbjct: 1722 NTSLINQKKKMESDLTQLQSEVEEAVQECRNAEEKAKKAITDAA--MMAEELKKEQDTSA 1779
Query: 426 TLEH---ELRREVEDLKLRLQMAAD-HYKEKFKECQRLQKQINKLSDQ 469
LE + + ++DL+ RL A K K+ Q+L+ ++ +L +
Sbjct: 1780 HLERMKKNMEQTIKDLQHRLDEAEQIALKGGKKQLQKLEARVRELEGE 1827
>gi|62243484 sarcoma antigen NY-SAR-41 [Homo sapiens]
Length = 1417
Score = 78.6 bits (192), Expect = 2e-14
Identities = 118/530 (22%), Positives = 229/530 (43%), Gaps = 58/530 (10%)
Query: 127 EELLTMEDEGNSDMLVVTTKAGLLELKIEKTMKEKEELLKLIAV----LEKETAQLREQV 182
EELL + +T K L L +EK ++EK IA LE+E + E++
Sbjct: 676 EELLEKASNSSKLESEMTKKCSQL-LTLEKQLEEKIVAYSSIAAKNAELEQELMEKNEKI 734
Query: 183 GRMERELN--HEK-----ERCDQLQAEQ-KGLTEVTQSLKMENEEFKKRFSDATSKAHQL 234
+E +N HEK E+ ++ EQ K + + + L+ + E+ ++F + L
Sbjct: 735 RSLETNINTEHEKICLAFEKAKKIHLEQHKEMEKQIERLEAQLEKKDQQFKEQEKTMSML 794
Query: 235 EEDIVSVTHKAIEKETELDSLKDKLKKAQHEREQLECQLKTEKDEKELYKVHLKNTEIEN 294
++DI+ H + L K ++KK ++++ L+ + E E KV ++ +E
Sbjct: 795 QQDIICKQHHLESLDRLLTESKGEMKKENMKKDEALKALQNQVSE-ETIKVRQLDSALEI 853
Query: 295 TKLMSEVQTLKNLDGNKESVITHFK---EEIGRLQLCLAEKENL------QRTFLLTTSS 345
K V L L+GNKE K EE+ LQ L K + Q L T
Sbjct: 854 CK-EELVLHLNQLEGNKEKFEKQLKKKSEEVYCLQKELKIKNHSLQETSEQNVILQHTLQ 912
Query: 346 KEDTCFLKEQLR---------KAEEQVQATRQEVVFLAKELSDAVN-VRDRTMADLHTAR 395
++ +E +R K E+QV QE+ + ++ + + ++ + H A
Sbjct: 913 QQQQMLQQETIRNGELEDTQTKLEKQVSKLEQELQKQRESSAEKLRKMEEKCESAAHEAD 972
Query: 396 LENEKVKKQLADA-VAELKLNAMKKDQDKTDTLEHELRREVEDLKL---RLQMAADHYKE 451
L+ +KV + A +++++ K++ K + L+R+ E+ + +L M D K
Sbjct: 973 LKRQKVIELTGTARQVKIEMDQYKEELSKMEKEIMHLKRDGENKAMHLSQLDMILDQTKT 1032
Query: 452 KFKECQRLQKQINKLSDQSANNNNVFTKKTGNQQKVNDASVNTDPATSASTVDVKPSPSA 511
+ ++ K++ KL + T+ T QK A ++K +
Sbjct: 1033 ELEKKTNAVKELEKLQHSTE------TELTEALQKREVLETELQNAHG----ELKSTLRQ 1082
Query: 512 AEADFDIVTKGQVC--EMTKEIADKTEKYNKCKQLLQDEKAKCNKYADELAKMELKWKEQ 569
+ D++ K Q+ E I D T + +CK ++D+K + + + A E W+ +
Sbjct: 1083 LQELRDVLQKAQLSLEEKYTTIKDLTAELRECKMEIEDKKQELLEM--DQALKERNWELK 1140
Query: 570 VKIAENVKLELAEVQDNYKELKRSLENPAERKMEGQNSQSPQCFKTCSEQ 619
+ A+ L++ ++++ E+++ + K+EG +S K C++Q
Sbjct: 1141 QRAAQVTHLDMT-IREHRGEMEQKI-----IKLEGTLEKSELELKECNKQ 1184
Score = 73.9 bits (180), Expect = 5e-13
Identities = 108/550 (19%), Positives = 228/550 (41%), Gaps = 62/550 (11%)
Query: 105 VTHKGEIRGASTPFQFRASSPVEELLTMEDEGN--SDMLVVTTKAGLLELKIEKTMKEKE 162
V H ++ G F+ + EE+ ++ E + L T++ ++ ++ T+++++
Sbjct: 859 VLHLNQLEGNKEKFEKQLKKKSEEVYCLQKELKIKNHSLQETSEQNVI---LQHTLQQQQ 915
Query: 163 ELLKLIAV----LEKETAQLREQVGRMERELNHEKE-----------RCDQLQAE----- 202
++L+ + LE +L +QV ++E+EL ++E +C+ E
Sbjct: 916 QMLQQETIRNGELEDTQTKLEKQVSKLEQELQKQRESSAEKLRKMEEKCESAAHEADLKR 975
Query: 203 QK--GLTEVTQSLKMENEEFKKRFSDATSKAHQLEEDIVSVTHKAIEKETELDSLKDKLK 260
QK LT + +K+E +++K+ S + L+ D + + + LD K +L+
Sbjct: 976 QKVIELTGTARQVKIEMDQYKEELSKMEKEIMHLKRDGENKAMHLSQLDMILDQTKTELE 1035
Query: 261 K---AQHEREQLECQLKTEKDE----KELYKVHLKNTEIENTKLMSEVQTLKNL----DG 309
K A E E+L+ +TE E +E+ + L+N E + ++Q L+++
Sbjct: 1036 KKTNAVKELEKLQHSTETELTEALQKREVLETELQNAHGELKSTLRQLQELRDVLQKAQL 1095
Query: 310 NKESVITHFKEEIGRLQLCLAEKENLQRTFL-LTTSSKEDTCFLKEQLRKAEEQVQATRQ 368
+ E T K+ L+ C E E+ ++ L + + KE LK++ + R+
Sbjct: 1096 SLEEKYTTIKDLTAELRECKMEIEDKKQELLEMDQALKERNWELKQRAAQVTHLDMTIRE 1155
Query: 369 EVVFLAKELSDAVNVRDRTMADLHTARLENEKVKKQLADAVAEL--KLNAMKKDQDKTDT 426
+ +++ +++ +L + E + +L +A +L K M +++ +
Sbjct: 1156 HRGEMEQKIIKLEGTLEKSELELKECNKQIESLNDKLQNAKEQLREKEFIMLQNEQEISQ 1215
Query: 427 LEHELRR------EVED-LKLRLQMAADHYKEKF----------KECQRLQKQINKLSDQ 469
L+ E+ R E+E +K + Q A YKE ++ Q ++ + Q
Sbjct: 1216 LKKEIERTQQRMKEMESVMKEQEQYIATQYKEAIDLGQELRLTREQVQNSHTELAEARHQ 1275
Query: 470 SANNNNVFTKKTGNQQKVNDASVNTDPATSASTVDVKPSPSAAEADFDIVTKGQVCEMTK 529
+ + + + S D A + + EA + + ++ +++
Sbjct: 1276 QVQAQREIERLSSELEDMKQLSKEKD-AHGNHLAEELGASKVREAHLEARMQAEIKKLSA 1334
Query: 530 EIADKTEKYNKCKQLLQDEKAKCNKYADELAKMELKWKEQVKIAENVKLELAEVQDNYKE 589
E+ E Y+ Q+ AK AD + EQ+ E KLEL E QD
Sbjct: 1335 EVESLKEAYHMEMISHQENHAKWKISADSQKSSVQQLNEQL---EKAKLELEEAQDTVSN 1391
Query: 590 LKRSLENPAE 599
L + +++ E
Sbjct: 1392 LHQQVQDRNE 1401
Score = 72.8 bits (177), Expect = 1e-12
Identities = 105/503 (20%), Positives = 219/503 (43%), Gaps = 82/503 (16%)
Query: 153 KIEKTMKEKEELLKLIAVLEKETAQLREQVGRMERELNHEKERCDQLQAEQKGLTEVTQS 212
K+EK E+E L + + EKE +L+E+ G + EL KE+ QL+ E E +
Sbjct: 380 KLEKVQAEEEILERNLTNCEKENKRLQERCGLYKSELEILKEKLRQLKEENNNGKEKLRI 439
Query: 213 LKMENEEFKKRFSDATSKAHQLEEDIVSVTHKAIEKETELDSLKDKLKKAQHEREQLECQ 272
+ ++N E + +++ +LE ++ E + + L+DK +E +L+ +
Sbjct: 440 MAVKNSEVMAQLTESRQSILKLESEL----------ENKDEILRDKF-SLMNENRELKVR 488
Query: 273 LKTEKDEKELYKVHLKNTEIE---NTKLMSEVQTLKNLDGNKESVITHFKEEIGRLQLCL 329
+ + + +L + ++++ +E K++S++ + L G FK + + Q+
Sbjct: 489 VAAQNERLDLCQQEIESSRVELRSLEKIISQLPLKRELFG--------FKSYLSKYQMS- 539
Query: 330 AEKENLQRTFLLTTSSKEDTCF------------LKEQLRKAEEQVQATRQEVVFLAKEL 377
+ S+KED C L+ +L E ++Q + A +L
Sbjct: 540 ------------SFSNKEDRCIGCCEANKLVISELRIKLAIKEAEIQKLHANLT--ANQL 585
Query: 378 SDAVNVRDRTMADLHTARLENEKVK---KQLADAVAELKLNAMKKDQDKTD----TLEHE 430
S ++ + + + LE E VK Q+A++V + + M K +K T E
Sbjct: 586 SQSLITCNDSQESSKLSSLETEPVKLGGHQVAESVKDQNQHTMNKQYEKERQRLVTGIEE 645
Query: 431 LRR-----EVEDLKLRLQMAADHYKEKFKECQRLQKQINKLSDQSANNNNVFTKKTGNQQ 485
LR E E+ L++ MA H +F Q +Q+++ + + S+ + TKK Q
Sbjct: 646 LRTKLIQIEAENSDLKVNMA--HRTSQF---QLIQEELLEKASNSSKLESEMTKKC--SQ 698
Query: 486 KVNDASVNTDPATSASTVDVKPSPSAAEADFDIVTKGQ-VCEMTKEIADKTEK----YNK 540
+ + + S++ K AE + +++ K + + + I + EK + K
Sbjct: 699 LLTLEKQLEEKIVAYSSIAAK----NAELEQELMEKNEKIRSLETNINTEHEKICLAFEK 754
Query: 541 CKQLLQDEKAKCNKYAD----ELAKMELKWKEQVKIAENVKLELAEVQDNYKELKRSLEN 596
K++ ++ + K + +L K + ++KEQ K ++ ++ Q + + L R L
Sbjct: 755 AKKIHLEQHKEMEKQIERLEAQLEKKDQQFKEQEKTMSMLQQDIICKQHHLESLDRLL-T 813
Query: 597 PAERKMEGQNSQSPQCFKTCSEQ 619
++ +M+ +N + + K Q
Sbjct: 814 ESKGEMKKENMKKDEALKALQNQ 836
Score = 69.7 bits (169), Expect = 1e-11
Identities = 97/521 (18%), Positives = 218/521 (41%), Gaps = 39/521 (7%)
Query: 137 NSDMLVVTTKAGLLELKIEKTMKEKEELLKLIAVLEKETAQLREQVGRMERELNHEKERC 196
NS+++ T++ LK+E ++ K+E+L+ L E +L+ +V L+ ++
Sbjct: 444 NSEVMAQLTESRQSILKLESELENKDEILRDKFSLMNENRELKVRVAAQNERLDLCQQEI 503
Query: 197 DQLQAEQKGLTEVTQSLKMENE--EFKKRFSDATSKAHQLEED------------IVSVT 242
+ + E + L ++ L ++ E FK S + +ED I +
Sbjct: 504 ESSRVELRSLEKIISQLPLKRELFGFKSYLSKYQMSSFSNKEDRCIGCCEANKLVISELR 563
Query: 243 HKAIEKETELDSLKDKLKKAQHEREQLEC---QLKTEKDEKELYKVHLKNTEI-ENTKLM 298
K KE E+ L L Q + + C Q ++ E V L ++ E+ K
Sbjct: 564 IKLAIKEAEIQKLHANLTANQLSQSLITCNDSQESSKLSSLETEPVKLGGHQVAESVKDQ 623
Query: 299 SEVQTLKNLDGNKESVITHFKEEIGRLQLCLAEKENLQRTFLLTTSS----KEDTCFLKE 354
++ K + ++ ++T +E +L AE +L+ TS +E+
Sbjct: 624 NQHTMNKQYEKERQRLVTGIEELRTKLIQIEAENSDLKVNMAHRTSQFQLIQEELLEKAS 683
Query: 355 QLRKAEEQVQATRQEVVFLAKELSDAVNVRDRTM---ADLHTARLE-NEKVKKQLADAVA 410
K E ++ +++ L K+L + + A+L +E NEK++ +
Sbjct: 684 NSSKLESEMTKKCSQLLTLEKQLEEKIVAYSSIAAKNAELEQELMEKNEKIRSLETNINT 743
Query: 411 ELKLNAMKKDQDKTDTLEH--ELRREVEDLKLRLQMAADHYKEKFKECQRLQKQINKLSD 468
E + + ++ K LE E+ +++E L+ +L+ +KE+ K LQ+ I
Sbjct: 744 EHEKICLAFEKAKKIHLEQHKEMEKQIERLEAQLEKKDQQFKEQEKTMSMLQQDIICKQH 803
Query: 469 QSANNNNVFTKKTGNQQKVN----DASVNTDPATSASTVDVKPSPSAAEADFDIVT---- 520
+ + + T+ G +K N +A S T+ V+ SA E + +
Sbjct: 804 HLESLDRLLTESKGEMKKENMKKDEALKALQNQVSEETIKVRQLDSALEICKEELVLHLN 863
Query: 521 --KGQVCEMTKEIADKTEKYNKCKQLLQDEKAKCNKYADELAKMELKWKEQVKIAENVKL 578
+G + K++ K+E+ ++ L+ + + +++ ++ ++Q ++ + +
Sbjct: 864 QLEGNKEKFEKQLKKKSEEVYCLQKELKIKNHSLQETSEQNVILQHTLQQQQQMLQQETI 923
Query: 579 ELAEVQDNYKELKRSLENPAERKMEGQNSQSPQCFKTCSEQ 619
E++D +L++ + + E++++ Q S + + E+
Sbjct: 924 RNGELEDTQTKLEKQV-SKLEQELQKQRESSAEKLRKMEEK 963
Score = 69.3 bits (168), Expect = 1e-11
Identities = 103/471 (21%), Positives = 191/471 (40%), Gaps = 77/471 (16%)
Query: 159 KEKEELLKLIAVLEKETAQLREQVGRMERELNHEKERCDQLQAEQKGLTEVTQSLKMENE 218
KE++ L+ I L + Q+ + ++ + H R Q Q Q+ L E +
Sbjct: 634 KERQRLVTGIEELRTKLIQIEAENSDLKVNMAH---RTSQFQLIQEELLEKASNSSKLES 690
Query: 219 EFKKRFSDATSKAHQLEEDIV---SVTHKAIEKETELDSLKDKLKKAQHEREQLECQLKT 275
E K+ S + QLEE IV S+ K E E EL +K++ LE + T
Sbjct: 691 EMTKKCSQLLTLEKQLEEKIVAYSSIAAKNAELEQELMEKNEKIRS-------LETNINT 743
Query: 276 EKDEKELYKVHLKNTEIENTKLMSEVQTLKNLDGNKESVITHFKEEIGRLQLC----LAE 331
E ++ L K +E K M + ++ L+ E FKE+ + + + +
Sbjct: 744 EHEKICLAFEKAKKIHLEQHKEMEK--QIERLEAQLEKKDQQFKEQEKTMSMLQQDIICK 801
Query: 332 KENLQRTFLLTTSSKEDTCFLKEQLRKAEEQVQATRQEV---VFLAKELSDAVNVRDRTM 388
+ +L+ L T SK + +K++ K +E ++A + +V ++L A+ + +
Sbjct: 802 QHHLESLDRLLTESKGE---MKKENMKKDEALKALQNQVSEETIKVRQLDSALEICKEEL 858
Query: 389 ADLHTARLEN--EKVKKQLADAVAE---------LKLNAMKKDQDKTDTLEHELRREVED 437
LH +LE EK +KQL E +K +++++ ++ L+H L+++ +
Sbjct: 859 V-LHLNQLEGNKEKFEKQLKKKSEEVYCLQKELKIKNHSLQETSEQNVILQHTLQQQQQ- 916
Query: 438 LKLRLQMAADHYKEKFKECQRLQKQINKLSDQSANNNNVFTKKTGNQQKVNDASVNTDPA 497
LQ E +L+KQ++KL + QK ++S A
Sbjct: 917 ---MLQQETIRNGELEDTQTKLEKQVSKLEQEL--------------QKQRESS-----A 954
Query: 498 TSASTVDVKPSPSAAEADFDIVTKGQVCEMTKEIADKTEKYNKCKQLLQDEKAKCNKYAD 557
++ K +A EAD K +K + + K + ++Y +
Sbjct: 955 EKLRKMEEKCESAAHEADL-----------------KRQKVIELTGTARQVKIEMDQYKE 997
Query: 558 ELAKMELKWKEQVKIAENVKLELAEVQDNYKELKRSLENPAERKMEGQNSQ 608
EL+KME + + EN + L+++ + K LE E + Q
Sbjct: 998 ELSKMEKEIMHLKRDGENKAMHLSQLDMILDQTKTELEKKTNAVKELEKLQ 1048
>gi|38045896 RAB6-interacting protein 2 isoform delta [Homo sapiens]
Length = 1088
Score = 78.2 bits (191), Expect = 3e-14
Identities = 104/485 (21%), Positives = 203/485 (41%), Gaps = 53/485 (10%)
Query: 139 DMLVVTTKAGLLELKIEKTM---------KEKEELLKLIAVLEKETAQLREQVGRMEREL 189
D + + + GL +L+ E M +E+EE +K + V + ++ ++G++++EL
Sbjct: 388 DSKISSMERGLRDLEEEIQMLKSNGALSTEEREEEMKQMEVYRSHSKFMKNKIGQVKQEL 447
Query: 190 NHEKERCDQLQAEQKGLTEVTQSLKMENEEFKKRFSDATSKAHQLEEDIVSVTHKAIEKE 249
+ + LQ + + LT +FSD+ L+E + + +A +
Sbjct: 448 SRKDTELLALQTKLETLTN--------------QFSDSKQHIEVLKESLTAKEQRAAILQ 493
Query: 250 TELDSLKDKLKKAQHEREQLECQLKTEKDEK--ELYKVH-----LKNTEIENTKLMSEVQ 302
TE+D+L+ +L++ + + Q++ +EK + ++H L E + L +++
Sbjct: 494 TEVDALRLRLEEKETMLNKKTKQIQDMAEEKGTQAGEIHDLKDMLDVKERKVNVLQKKIE 553
Query: 303 TLKNLDGNKESVITHFKEEIGRLQLCLAEKENLQRTFLLTTSSKEDTC-FLKEQLRKAEE 361
L+ +KE ++ KE + LQ + T + KE T LKEQ + E
Sbjct: 554 NLQEQLRDKEKQMSSLKERVKSLQADTTNTDTALTTLEEALAEKERTIERLKEQRDRDER 613
Query: 362 QVQATRQEVVFLAKELSDAVNVRDRTMADLHTARLENEKVKKQLADAVAELKLNAMKKDQ 421
+ Q +E+ K+L D DL E E L + + L + +KKD
Sbjct: 614 EKQ---EEIDNYKKDLKDLKEKVSLLQGDLS----EKEASLLDLKEHASSLASSGLKKD- 665
Query: 422 DKTDTLEHELRREVED-LKLRLQMAADH--------YKEKFKECQRLQKQINKLSDQSAN 472
+ TLE L ++ E+ LK+ Q+ H E Q L+++I + D+S+
Sbjct: 666 SRLKTLEIALEQKKEECLKMESQLKKAHEAALEARASPEMSDRIQHLEREITRYKDESSK 725
Query: 473 NNNVFTKKTGNQQKVNDASVNTDPATSASTVDVKPSPS--AAEADFDIVTKGQVCEMTKE 530
+ ++V + + D + VK A + V K + +M +E
Sbjct: 726 AQAEVDRLLEILKEVENEKNDKDKKIAELERQVKDQNKKVANLKHKEQVEKKKSAQMLEE 785
Query: 531 IADKTEKYNKCKQLLQDEKAKCNKYADELAKMELKWKEQVKIAENVKLELAEVQDNYKEL 590
+ + N Q LQD K D + ++E +E V+I ++ LA+ +
Sbjct: 786 ARRREDNLNDSSQQLQD---SLRKKDDRIEELEEALRESVQITAEREMVLAQEESARTNA 842
Query: 591 KRSLE 595
++ +E
Sbjct: 843 EKQVE 847
Score = 76.6 bits (187), Expect = 8e-14
Identities = 100/482 (20%), Positives = 200/482 (41%), Gaps = 58/482 (12%)
Query: 110 EIRGASTPFQFRASSPVEELLTMEDEGNSDMLVVTTKAGLLELKIEKTMKEKEELLKLIA 169
E+ + + F V++ L+ +D +++L + TK L + + + E L + +
Sbjct: 427 EVYRSHSKFMKNKIGQVKQELSRKD---TELLALQTKLETLTNQFSDSKQHIEVLKESLT 483
Query: 170 VLEKETAQLREQVGRMERELNHEKERCDQLQAEQKGLTEVTQSLKMENEEFKKRFSDATS 229
E+ A L+ +V + L ++ ++ + + + E + E + K
Sbjct: 484 AKEQRAAILQTEVDALRLRLEEKETMLNKKTKQIQDMAEEKGTQAGEIHDLKDMLDVKER 543
Query: 230 KAHQLEEDIVSVTHKAIEKETELDSLKDKLKKAQ-----------------HEREQLECQ 272
K + L++ I ++ + +KE ++ SLK+++K Q E+E+ +
Sbjct: 544 KVNVLQKKIENLQEQLRDKEKQMSSLKERVKSLQADTTNTDTALTTLEEALAEKERTIER 603
Query: 273 LKTEKDEKELYKVHLKNTEIENTK-----LMSEVQTLKNLDGNKESVITHFKEEIGRLQL 327
LK ++D E K EI+N K L +V L+ KE+ + KE L
Sbjct: 604 LKEQRDRDE----REKQEEIDNYKKDLKDLKEKVSLLQGDLSEKEASLLDLKEHASSLAS 659
Query: 328 CLAEKENLQRTFLLTTSSKEDTCF-LKEQLRKAEEQVQATRQEVVFLAKELSDAVNVRDR 386
+K++ +T + K++ C ++ QL+KA E R + E+SD + +R
Sbjct: 660 SGLKKDSRLKTLEIALEQKKEECLKMESQLKKAHEAALEAR-----ASPEMSDRIQHLER 714
Query: 387 TMADLHTARLENEKVKKQL-ADAVAELKLNAMKKDQDKTDTLEHELRREVEDLKLRL-QM 444
+ R ++E K Q D + E+ L ++ +++ D EL R+V+D ++ +
Sbjct: 715 EI-----TRYKDESSKAQAEVDRLLEI-LKEVENEKNDKDKKIAELERQVKDQNKKVANL 768
Query: 445 AADHYKEKFKECQRLQ---KQINKLSDQSANNNNVFTKKTGNQQKVNDASVNTDPATSAS 501
EK K Q L+ ++ + L+D S + KK +++ +A + T+
Sbjct: 769 KHKEQVEKKKSAQMLEEARRREDNLNDSSQQLQDSLRKKDDRIEELEEALRESVQITAER 828
Query: 502 TVDVKPSPSAAEADFDIVTKGQVCEMTKEIADKTEKYNKCKQLLQDEKAKCNKYADELAK 561
+ + SA K++ + K KQ L+ KAK + LA+
Sbjct: 829 EMVLAQEESAR------------TNAEKQVEELLMAMEKVKQELESMKAKLSSTQQSLAE 876
Query: 562 ME 563
E
Sbjct: 877 KE 878
Score = 58.5 bits (140), Expect = 2e-08
Identities = 66/320 (20%), Positives = 128/320 (40%), Gaps = 51/320 (15%)
Query: 150 LELKIEKTMKEKEELLKL--IAVLEKETAQLREQVGRMERELNHEKERCDQLQAEQKGLT 207
LE K E+ +K + +L K A+ + + ++ +++ +ERE+ K+ + QAE L
Sbjct: 675 LEQKKEECLKMESQLKKAHEAALEARASPEMSDRIQHLEREITRYKDESSKAQAEVDRLL 734
Query: 208 EVTQSLKMENEEFKKRFSDATSKAHQLEEDIVSVTHK--------------AIEKETELD 253
E+ + ++ E + K+ ++ + + + ++ HK A +E L+
Sbjct: 735 EILKEVENEKNDKDKKIAELERQVKDQNKKVANLKHKEQVEKKKSAQMLEEARRREDNLN 794
Query: 254 S----LKDKLKKAQHEREQLECQLKTEKDEKELYKVHLKNTEIENTKLMSEVQTLKNLDG 309
L+D L+K E+LE L+ ++ L E T +V+ L
Sbjct: 795 DSSQQLQDSLRKKDDRIEELEEALRESVQITAEREMVLAQEESARTNAEKQVEELLMAME 854
Query: 310 NKESVITHFKEEIGRLQLCLAEKEN------------------LQRTFLLTTSSKEDTCF 351
+ + K ++ Q LAEKE +++ LL S++D
Sbjct: 855 KVKQELESMKAKLSSTQQSLAEKETHLTNLRAERRKHLEEVLEMKQEALLAAISEKDANI 914
Query: 352 ----LKEQLRKAEEQVQATRQEVVFLAKELSDAVNVRDRTMAD---------LHTARLEN 398
L +K +E+V A ++E L ++L R + MAD H+ + +
Sbjct: 915 ALLELSSSKKKTQEEVAALKREKDRLVQQLKQQTQNRMKLMADNYEDDHFKSSHSNQTNH 974
Query: 399 EKVKKQLADAVAELKLNAMK 418
+ Q+ + EL N K
Sbjct: 975 KPSPDQIIQPLLELDQNRSK 994
Score = 37.0 bits (84), Expect = 0.071
Identities = 74/420 (17%), Positives = 161/420 (38%), Gaps = 51/420 (12%)
Query: 248 KETELDSLKDKLKKAQHEREQLECQLKTEKDEK-ELYKVHLKNTEIENTKLMSEVQTLKN 306
KE++L S + +K + E L+ ++ K ++K + + EN + +Q L++
Sbjct: 175 KESKLSSSMNSIKTFWSPELKKERALRKDEASKITIWKEQYRVVQEENQHMQMTIQALQD 234
Query: 307 LDGNKESVITHFKEEIGRL--QLCLAE--KENLQRTFLLTTSSKEDTCFLKEQLRKAEEQ 362
+ + F+++ + C+AE +EN QR ++ L++ L + E +
Sbjct: 235 ELRIQRDLNQLFQQDSSSRTGEPCVAELTEENFQRLHAEHERQAKELFLLRKTLEEMELR 294
Query: 363 VQATRQEV------------VFLAKELS------DAVNVRDRTMADLHTARLEN------ 398
++ +Q + + +K LS D R A++H LE+
Sbjct: 295 IETQKQTLNARDESIKKLLEMLQSKGLSAKATEEDHERTRRLAEAEMHVHHLESLLEQKE 354
Query: 399 -------EKVKKQLADAVAELKLNAMKKDQDKTDTLEHELRREVEDLKLRLQMAADHYKE 451
E++ ++ +A K A++ + D+ + R + DL+ +QM +
Sbjct: 355 KENSMLREEMHRRFENAPDSAKTKALQTVIEMKDSKISSMERGLRDLEEEIQMLKSNGAL 414
Query: 452 KFKECQRLQKQI-----------NKLSDQSANNNNVFTKKTGNQQKVNDASVNTDPATSA 500
+E + KQ+ NK+ + T+ Q K+ ++ + S
Sbjct: 415 STEEREEEMKQMEVYRSHSKFMKNKIGQVKQELSRKDTELLALQTKLE--TLTNQFSDSK 472
Query: 501 STVDVKPSPSAAEADFDIVTKGQVCEMTKEIADKTEKYNKCKQLLQDEKAKCNKYADELA 560
++V A+ + + +V + + +K NK + +QD + A E+
Sbjct: 473 QHIEVLKESLTAKEQRAAILQTEVDALRLRLEEKETMLNKKTKQIQDMAEEKGTQAGEIH 532
Query: 561 KME--LKWKEQVKIAENVKLELAEVQDNYKELKRSLENPAERKMEGQNSQSPQCFKTCSE 618
++ L KE+ K+E + Q KE + S + ++ + + T E
Sbjct: 533 DLKDMLDVKERKVNVLQKKIENLQEQLRDKEKQMSSLKERVKSLQADTTNTDTALTTLEE 592
Database: hs.faa
Posted date: Aug 4, 2009 4:42 PM
Number of letters in database: 18,247,518
Number of sequences in database: 37,866
Lambda K H
0.313 0.129 0.369
Gapped
Lambda K H
0.267 0.0410 0.140
Matrix: BLOSUM62
Gap Penalties: Existence: 11, Extension: 1
Number of Hits to DB: 30,992,429
Number of Sequences: 37866
Number of extensions: 1547824
Number of successful extensions: 14483
Number of sequences better than 10.0: 30
Number of HSP's better than 10.0 without gapping: 387
Number of HSP's successfully gapped in prelim test: 916
Number of HSP's that attempted gapping in prelim test: 6616
Number of HSP's gapped (non-prelim): 4580
length of query: 789
length of database: 18,247,518
effective HSP length: 110
effective length of query: 679
effective length of database: 14,082,258
effective search space: 9561853182
effective search space used: 9561853182
T: 11
A: 40
X1: 16 ( 7.2 bits)
X2: 38 (14.6 bits)
X3: 64 (24.7 bits)
S1: 42 (21.9 bits)
S2: 66 (30.0 bits)
Search results were obtained with NCBI BLAST and RefSeq entries.
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Guide to the Human Genome
Copyright © 2010 by Stewart Scherer. All rights reserved.