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Search of human proteins with 21361670
BLASTP 2.2.11 [Jun-05-2005]
Reference: Altschul, Stephen F., Thomas L. Madden, Alejandro A. Schaffer,
Jinghui Zhang, Zheng Zhang, Webb Miller, and David J. Lipman (1997),
"Gapped BLAST and PSI-BLAST: a new generation of protein database search
programs", Nucleic Acids Res. 25:3389-3402.
Query= gi|21361670 drebrin-like isoform a [Homo sapiens]
(431 letters)
Database: hs.faa
37,866 sequences; 18,247,518 total letters
Searching..................................................done
Score E
Sequences producing significant alignments: (bits) Value
gi|21361670 drebrin-like isoform a [Homo sapiens] 875 0.0
gi|62198235 drebrin-like isoform b [Homo sapiens] 869 0.0
gi|171906575 drebrin-like isoform c [Homo sapiens] 868 0.0
gi|18426915 drebrin 1 isoform a [Homo sapiens] 214 2e-55
gi|18426913 drebrin 1 isoform b [Homo sapiens] 197 2e-50
gi|167234422 hematopoietic cell-specific Lyn substrate 1 [Homo s... 105 6e-23
gi|20357552 cortactin isoform a [Homo sapiens] 101 1e-21
gi|20357556 cortactin isoform b [Homo sapiens] 101 1e-21
gi|5453710 LIM and SH3 protein 1 [Homo sapiens] 64 2e-10
gi|194294523 intersectin 2 isoform 3 [Homo sapiens] 64 3e-10
gi|194294521 intersectin 2 isoform 1 [Homo sapiens] 64 3e-10
gi|194294525 intersectin 2 isoform 2 [Homo sapiens] 64 3e-10
gi|78042577 MAP7 domain containing 1 [Homo sapiens] 60 3e-09
gi|102467235 inner centromere protein antigens 135/155kDa isofor... 57 2e-08
gi|102467242 inner centromere protein antigens 135/155kDa isofor... 57 2e-08
gi|115527120 nebulin [Homo sapiens] 56 6e-08
gi|47087157 nebulette non-muscle isoform [Homo sapiens] 55 9e-08
gi|4506931 SH3-domain GRB2-like 2 [Homo sapiens] 53 5e-07
gi|5453758 nebulette sarcomeric isoform [Homo sapiens] 53 6e-07
gi|148747351 protein kinase C and casein kinase substrate in neu... 53 6e-07
gi|4507249 signal transducing adaptor molecule 1 [Homo sapiens] 52 1e-06
gi|48255891 protein kinase C substrate 80K-H isoform 2 [Homo sap... 52 1e-06
gi|15011979 Rho guanine nucleotide exchange factor 4 isoform a [... 51 2e-06
gi|15011981 Rho guanine nucleotide exchange factor 4 isoform b [... 51 2e-06
gi|239745089 PREDICTED: golgi autoantigen, golgin subfamily a-li... 51 2e-06
gi|24308229 protein kinase C and casein kinase substrate in neur... 51 2e-06
gi|148746195 trichohyalin [Homo sapiens] 50 4e-06
gi|19224660 protein kinase C and casein kinase substrate in neur... 50 4e-06
gi|56549694 enabled homolog isoform a [Homo sapiens] 50 5e-06
gi|39930375 enabled homolog isoform b [Homo sapiens] 50 5e-06
>gi|21361670 drebrin-like isoform a [Homo sapiens]
Length = 431
Score = 875 bits (2261), Expect = 0.0
Identities = 431/431 (100%), Positives = 431/431 (100%)
Query: 1 MAANLSRNGPALQEAYVRVVTEKSPTDWALFTYEGNSNDIRVAGTGEGGLEEMVEELNSG 60
MAANLSRNGPALQEAYVRVVTEKSPTDWALFTYEGNSNDIRVAGTGEGGLEEMVEELNSG
Sbjct: 1 MAANLSRNGPALQEAYVRVVTEKSPTDWALFTYEGNSNDIRVAGTGEGGLEEMVEELNSG 60
Query: 61 KVMYAFCRVKDPNSGLPKFVLINWTGEGVNDVRKGACASHVSTMASFLKGAHVTINARAE 120
KVMYAFCRVKDPNSGLPKFVLINWTGEGVNDVRKGACASHVSTMASFLKGAHVTINARAE
Sbjct: 61 KVMYAFCRVKDPNSGLPKFVLINWTGEGVNDVRKGACASHVSTMASFLKGAHVTINARAE 120
Query: 121 EDVEPECIMEKVAKASGANYSFHKESGRFQDVGPQAPVGSVYQKTNAVSEIKRVGKDSFW 180
EDVEPECIMEKVAKASGANYSFHKESGRFQDVGPQAPVGSVYQKTNAVSEIKRVGKDSFW
Sbjct: 121 EDVEPECIMEKVAKASGANYSFHKESGRFQDVGPQAPVGSVYQKTNAVSEIKRVGKDSFW 180
Query: 181 AKAEKEEENRRLEEKRRAEEAQRQLEQERRERELREAARREQRYQEQGGEASPQSRTWEQ 240
AKAEKEEENRRLEEKRRAEEAQRQLEQERRERELREAARREQRYQEQGGEASPQSRTWEQ
Sbjct: 181 AKAEKEEENRRLEEKRRAEEAQRQLEQERRERELREAARREQRYQEQGGEASPQSRTWEQ 240
Query: 241 QQEVVSRNRNEQESAVHPREIFKQKERAMSTTSISSPQPGKLRSPFLQKQLTQPETHFGR 300
QQEVVSRNRNEQESAVHPREIFKQKERAMSTTSISSPQPGKLRSPFLQKQLTQPETHFGR
Sbjct: 241 QQEVVSRNRNEQESAVHPREIFKQKERAMSTTSISSPQPGKLRSPFLQKQLTQPETHFGR 300
Query: 301 EPAAAISRPRADLPAEEPAPSTPPCLVQAEEEAVYEEPPEQETFYEQPPLVQQQGAGSEH 360
EPAAAISRPRADLPAEEPAPSTPPCLVQAEEEAVYEEPPEQETFYEQPPLVQQQGAGSEH
Sbjct: 301 EPAAAISRPRADLPAEEPAPSTPPCLVQAEEEAVYEEPPEQETFYEQPPLVQQQGAGSEH 360
Query: 361 IDHHIQGQGLSGQGLCARALYDYQAADDTEISFDPENLITGIEVIDEGWWRGYGPDGHFG 420
IDHHIQGQGLSGQGLCARALYDYQAADDTEISFDPENLITGIEVIDEGWWRGYGPDGHFG
Sbjct: 361 IDHHIQGQGLSGQGLCARALYDYQAADDTEISFDPENLITGIEVIDEGWWRGYGPDGHFG 420
Query: 421 MFPANYVELIE 431
MFPANYVELIE
Sbjct: 421 MFPANYVELIE 431
>gi|62198235 drebrin-like isoform b [Homo sapiens]
Length = 430
Score = 869 bits (2245), Expect = 0.0
Identities = 430/431 (99%), Positives = 430/431 (99%), Gaps = 1/431 (0%)
Query: 1 MAANLSRNGPALQEAYVRVVTEKSPTDWALFTYEGNSNDIRVAGTGEGGLEEMVEELNSG 60
MAANLSRNGPALQEAYVRVVTEKSPTDWALFTYEGNSNDIRVAGTGEGGLEEMVEELNSG
Sbjct: 1 MAANLSRNGPALQEAYVRVVTEKSPTDWALFTYEGNSNDIRVAGTGEGGLEEMVEELNSG 60
Query: 61 KVMYAFCRVKDPNSGLPKFVLINWTGEGVNDVRKGACASHVSTMASFLKGAHVTINARAE 120
KVMYAFCRVKDPNSGLPKFVLINWTGEGVNDVRKGACASHVSTMASFLKGAHVTINARAE
Sbjct: 61 KVMYAFCRVKDPNSGLPKFVLINWTGEGVNDVRKGACASHVSTMASFLKGAHVTINARAE 120
Query: 121 EDVEPECIMEKVAKASGANYSFHKESGRFQDVGPQAPVGSVYQKTNAVSEIKRVGKDSFW 180
EDVEPECIMEKVAKASGANYSFHKESGRFQDVGPQAPVGSVYQKTNAVSEIKRVGKDSFW
Sbjct: 121 EDVEPECIMEKVAKASGANYSFHKESGRFQDVGPQAPVGSVYQKTNAVSEIKRVGKDSFW 180
Query: 181 AKAEKEEENRRLEEKRRAEEAQRQLEQERRERELREAARREQRYQEQGGEASPQSRTWEQ 240
AKAEKEEENRRLEEKRRAEEAQRQLEQERRERELREAARREQRYQEQGGEASPQ RTWEQ
Sbjct: 181 AKAEKEEENRRLEEKRRAEEAQRQLEQERRERELREAARREQRYQEQGGEASPQ-RTWEQ 239
Query: 241 QQEVVSRNRNEQESAVHPREIFKQKERAMSTTSISSPQPGKLRSPFLQKQLTQPETHFGR 300
QQEVVSRNRNEQESAVHPREIFKQKERAMSTTSISSPQPGKLRSPFLQKQLTQPETHFGR
Sbjct: 240 QQEVVSRNRNEQESAVHPREIFKQKERAMSTTSISSPQPGKLRSPFLQKQLTQPETHFGR 299
Query: 301 EPAAAISRPRADLPAEEPAPSTPPCLVQAEEEAVYEEPPEQETFYEQPPLVQQQGAGSEH 360
EPAAAISRPRADLPAEEPAPSTPPCLVQAEEEAVYEEPPEQETFYEQPPLVQQQGAGSEH
Sbjct: 300 EPAAAISRPRADLPAEEPAPSTPPCLVQAEEEAVYEEPPEQETFYEQPPLVQQQGAGSEH 359
Query: 361 IDHHIQGQGLSGQGLCARALYDYQAADDTEISFDPENLITGIEVIDEGWWRGYGPDGHFG 420
IDHHIQGQGLSGQGLCARALYDYQAADDTEISFDPENLITGIEVIDEGWWRGYGPDGHFG
Sbjct: 360 IDHHIQGQGLSGQGLCARALYDYQAADDTEISFDPENLITGIEVIDEGWWRGYGPDGHFG 419
Query: 421 MFPANYVELIE 431
MFPANYVELIE
Sbjct: 420 MFPANYVELIE 430
>gi|171906575 drebrin-like isoform c [Homo sapiens]
Length = 439
Score = 868 bits (2242), Expect = 0.0
Identities = 431/439 (98%), Positives = 431/439 (98%), Gaps = 8/439 (1%)
Query: 1 MAANLSRNGPALQEAYVRVVTEKSPTDWALFTYEGNSNDIRVAGTGEGGLEEMVEELNSG 60
MAANLSRNGPALQEAYVRVVTEKSPTDWALFTYEGNSNDIRVAGTGEGGLEEMVEELNSG
Sbjct: 1 MAANLSRNGPALQEAYVRVVTEKSPTDWALFTYEGNSNDIRVAGTGEGGLEEMVEELNSG 60
Query: 61 KVMYAFCRVKDPNSGLPKFVLINWTGEGVNDVRKGACASHVSTMASFLKGAHVTINARAE 120
KVMYAFCRVKDPNSGLPKFVLINWTGEGVNDVRKGACASHVSTMASFLKGAHVTINARAE
Sbjct: 61 KVMYAFCRVKDPNSGLPKFVLINWTGEGVNDVRKGACASHVSTMASFLKGAHVTINARAE 120
Query: 121 EDVEPECIMEKVAKASGANYSFHKESGRFQDVGPQAPVGSVYQKTNAVSEIKRVGKDSFW 180
EDVEPECIMEKVAKASGANYSFHKESGRFQDVGPQAPVGSVYQKTNAVSEIKRVGKDSFW
Sbjct: 121 EDVEPECIMEKVAKASGANYSFHKESGRFQDVGPQAPVGSVYQKTNAVSEIKRVGKDSFW 180
Query: 181 AKAEKEEENRRLEEKRRAEEAQRQLEQERRERELREAARREQRYQEQGGEASPQSRTWEQ 240
AKAEKEEENRRLEEKRRAEEAQRQLEQERRERELREAARREQRYQEQGGEASPQSRTWEQ
Sbjct: 181 AKAEKEEENRRLEEKRRAEEAQRQLEQERRERELREAARREQRYQEQGGEASPQSRTWEQ 240
Query: 241 QQEVVSRNRNE--------QESAVHPREIFKQKERAMSTTSISSPQPGKLRSPFLQKQLT 292
QQEVVSRNRNE QESAVHPREIFKQKERAMSTTSISSPQPGKLRSPFLQKQLT
Sbjct: 241 QQEVVSRNRNEQGSTCASLQESAVHPREIFKQKERAMSTTSISSPQPGKLRSPFLQKQLT 300
Query: 293 QPETHFGREPAAAISRPRADLPAEEPAPSTPPCLVQAEEEAVYEEPPEQETFYEQPPLVQ 352
QPETHFGREPAAAISRPRADLPAEEPAPSTPPCLVQAEEEAVYEEPPEQETFYEQPPLVQ
Sbjct: 301 QPETHFGREPAAAISRPRADLPAEEPAPSTPPCLVQAEEEAVYEEPPEQETFYEQPPLVQ 360
Query: 353 QQGAGSEHIDHHIQGQGLSGQGLCARALYDYQAADDTEISFDPENLITGIEVIDEGWWRG 412
QQGAGSEHIDHHIQGQGLSGQGLCARALYDYQAADDTEISFDPENLITGIEVIDEGWWRG
Sbjct: 361 QQGAGSEHIDHHIQGQGLSGQGLCARALYDYQAADDTEISFDPENLITGIEVIDEGWWRG 420
Query: 413 YGPDGHFGMFPANYVELIE 431
YGPDGHFGMFPANYVELIE
Sbjct: 421 YGPDGHFGMFPANYVELIE 439
>gi|18426915 drebrin 1 isoform a [Homo sapiens]
Length = 649
Score = 214 bits (544), Expect = 2e-55
Identities = 129/372 (34%), Positives = 201/372 (54%), Gaps = 43/372 (11%)
Query: 3 ANLSRNGPALQ--EAYVRVVTEKSPTDWALFTYEGNSNDIRVAGTGEGGLEEMVEELNSG 60
A +S +G L+ AY V+ E+S DWAL+TYE S+D+++A +GEGGL+E+ +
Sbjct: 2 AGVSFSGHRLELLAAYEEVIREESAADWALYTYEDGSDDLKLAASGEGGLQELSGHFENQ 61
Query: 61 KVMYAFCRVKDPNSGLPKFVLINWTGEGVNDVRKGACASHVSTMASFLKGAHVTINARAE 120
KVMY FC VKD + LPK+VLINW GE V D RK ACASHV+ +A F +G V +NA +
Sbjct: 62 KVMYGFCSVKDSQAALPKYVLINWVGEDVPDARKCACASHVAKVAEFFQGVDVIVNASSV 121
Query: 121 EDVEPECIMEKVAKASGANYSFHKESGRFQDVGPQAPVGSVYQKTNAVSEIKRVGKDSFW 180
ED++ I ++++ S R ++ PVG+ YQKT+A E+KR+ ++ FW
Sbjct: 122 EDIDAGAIGQRLSNGLARLSSPVLHRLRLREDENAEPVGTTYQKTDAAVEMKRINREQFW 181
Query: 181 AKAEKEEENRRLEEKRRAEEAQRQLEQERRERELREAARREQRYQEQGGEASPQSRTWE- 239
+A+KEEE R+ EE+++A + + + EQER E+E +E RE+RY+E+ + R +
Sbjct: 182 EQAKKEEELRKEEERKKALDERLRFEQERMEQERQEQEERERRYREREQQIEEHRRKQQT 241
Query: 240 ----------QQQEVVSRNRNEQESA--------------------VHPREIFKQKERAM 269
++Q + +R+E+E +PRE FKQ+ER
Sbjct: 242 LEAEEAKRRLKEQSIFGDHRDEEEETHMKKSESEVEEAAAIIAQRPDNPREFFKQQERVA 301
Query: 270 STTSISSPQPGKLRSPFLQKQLTQPETHFGREPAAAISRPRADLPAEEPAPSTPPC--LV 327
S ++ S P SPF + + ++H P +R P++ STP +
Sbjct: 302 SASAGSCDVP----SPFNHRPGSHLDSHRRMAPTPIPTRS----PSDSSTASTPVAEQIE 353
Query: 328 QAEEEAVYEEPP 339
+A +E +PP
Sbjct: 354 RALDEVTSSQPP 365
>gi|18426913 drebrin 1 isoform b [Homo sapiens]
Length = 651
Score = 197 bits (501), Expect = 2e-50
Identities = 118/344 (34%), Positives = 185/344 (53%), Gaps = 41/344 (11%)
Query: 29 ALFTYEGNSNDIRVAGTGEGGLEEMVEELNSGKVMYAFCRVKDPNSGLPKFVLINWTGEG 88
AL+TYE S+D+++A +GEGGL+E+ + KVMY FC VKD + LPK+VLINW GE
Sbjct: 32 ALYTYEDGSDDLKLAASGEGGLQELSGHFENQKVMYGFCSVKDSQAALPKYVLINWVGED 91
Query: 89 VNDVRKGACASHVSTMASFLKGAHVTINARAEEDVEPECIMEKVAKASGANYSFHKESGR 148
V D RK ACASHV+ +A F +G V +NA + ED++ I ++++ S R
Sbjct: 92 VPDARKCACASHVAKVAEFFQGVDVIVNASSVEDIDAGAIGQRLSNGLARLSSPVLHRLR 151
Query: 149 FQDVGPQAPVGSVYQKTNAVSEIKRVGKDSFWAKAEKEEENRRLEEKRRAEEAQRQLEQE 208
++ PVG+ YQKT+A E+KR+ ++ FW +A+KEEE R+ EE+++A + + + EQE
Sbjct: 152 LREDENAEPVGTTYQKTDAAVEMKRINREQFWEQAKKEEELRKEEERKKALDERLRFEQE 211
Query: 209 RRERELREAARREQRYQEQGGEASPQSRTWE-----------QQQEVVSRNRNEQESA-- 255
R E+E +E RE+RY+E+ + R + ++Q + +R+E+E
Sbjct: 212 RMEQERQEQEERERRYREREQQIEEHRRKQQTLEAEEAKRRLKEQSIFGDHRDEEEETHM 271
Query: 256 ------------------VHPREIFKQKERAMSTTSISSPQPGKLRSPFLQKQLTQPETH 297
+PRE FKQ+ER S ++ S P SPF + + ++H
Sbjct: 272 KKSESEVEEAAAIIAQRPDNPREFFKQQERVASASAGSCDVP----SPFNHRPGSHLDSH 327
Query: 298 FGREPAAAISRPRADLPAEEPAPSTPPC--LVQAEEEAVYEEPP 339
P +R P++ STP + +A +E +PP
Sbjct: 328 RRMAPTPIPTRS----PSDSSTASTPVAEQIERALDEVTSSQPP 367
>gi|167234422 hematopoietic cell-specific Lyn substrate 1 [Homo
sapiens]
Length = 486
Score = 105 bits (263), Expect = 6e-23
Identities = 103/344 (29%), Positives = 138/344 (40%), Gaps = 93/344 (27%)
Query: 133 AKASGANYSFHKESGRFQDVG---PQAPVGSVYQKTNAVSEIKRVGKDSFWAKAEKEEEN 189
AK G Y K+ VG +AP + Y+KT + E G AK E
Sbjct: 191 AKGFGGQYGIQKDRVDKSAVGFNEMEAPT-TAYKKTTPI-EAASSGTRGLKAKFES---- 244
Query: 190 RRLEEKRRAEEAQRQLEQERRERELREAARREQRYQEQGGEASPQSRTWEQQQEVVSRNR 249
EEKR+ EE ++ + RR++E + +R SP E Q V+
Sbjct: 245 -MAEEKRKREEEEKAQQVARRQQERKAVTKR-----------SP-----EAPQPVI---- 283
Query: 250 NEQESAVHPREIFKQKERAMSTTSISSPQPGKLRSPFLQKQLTQPETHF-----GREPAA 304
AM ++ +P P K+ S T P + RE
Sbjct: 284 ------------------AMEEPAVPAPLPKKISSEAWPPVGTPPSSESEPVRTSREHPV 325
Query: 305 AISRPRADLPAE-EPAPSTPPCLV---QAEEEAVYEEPPEQETFYEQPPLVQQQGAGSEH 360
+ R LP + E P+ PP + Q EEE VYE PE E E P + E
Sbjct: 326 PLLPIRQTLPEDNEEPPALPPRTLEGLQVEEEPVYEAEPEPEP--EPEPEPENDYEDVEE 383
Query: 361 IDHHIQ---------------------------------GQGLSGQGLCARALYDYQAAD 387
+D H Q G G G+ A ALYDYQ
Sbjct: 384 MDRHEQEDEPEGDYEEVLEPEDSSFSSALAGSSGCPAGAGAGAVALGISAVALYDYQGEG 443
Query: 388 DTEISFDPENLITGIEVIDEGWWRGYGPDGHFGMFPANYVELIE 431
E+SFDP+++IT IE++DEGWWRG GHFG+FPANYV+L+E
Sbjct: 444 SDELSFDPDDVITDIEMVDEGWWRG-RCHGHFGLFPANYVKLLE 486
>gi|20357552 cortactin isoform a [Homo sapiens]
Length = 550
Score = 101 bits (251), Expect = 1e-21
Identities = 92/304 (30%), Positives = 128/304 (42%), Gaps = 65/304 (21%)
Query: 133 AKASGANYSFHKE-----SGRFQDVGPQAPVGSVYQKTNAVSEIKRVGKDSFWAKAEKEE 187
+K G Y K+ + F+DV V S YQKT V + +K
Sbjct: 303 SKGFGGKYGVQKDRMDKNASTFEDV---TQVSSAYQKTVPVEAVT--------SKTSNIR 351
Query: 188 ENRRLEEKRRAEEAQRQLEQERRERELREAARREQRYQEQGGEASPQSRTWEQQQEVVSR 247
N K + +E +R+ E ER +R +E
Sbjct: 352 ANFENLAKEKEQEDRRKAEAERAQRMAKE------------------------------- 380
Query: 248 NRNEQESAVHPREIFKQKERAMSTTSISSPQPGKLRSPFLQKQLTQPETHFGREPAAAIS 307
R EQE A R +++ RA + T SP P P ++ + P E AA+
Sbjct: 381 -RQEQEEA---RRKLEEQARAKTQTPPVSPAP----QPTEERLPSSPVY----EDAASF- 427
Query: 308 RPRADLPAEEPAPSTPPCLVQAEEEAVYEEPPEQETFYEQPPLVQQQGAGSEHI--DHHI 365
+A+L P T P V + E A Y E Q+ V + H +
Sbjct: 428 --KAELSYRGPVSGTEPEPVYSMEAADYREASSQQGLAYATEAVYESAEAPGHYPAEDST 485
Query: 366 QGQGLSGQGLCARALYDYQAADDTEISFDPENLITGIEVIDEGWWRGYGPDGHFGMFPAN 425
+ + G+ A ALYDYQAA D EISFDP+++IT IE+ID+GWWRG G +G+FPAN
Sbjct: 486 YDEYENDLGITAVALYDYQAAGDDEISFDPDDIITNIEMIDDGWWRGV-CKGRYGLFPAN 544
Query: 426 YVEL 429
YVEL
Sbjct: 545 YVEL 548
>gi|20357556 cortactin isoform b [Homo sapiens]
Length = 513
Score = 101 bits (251), Expect = 1e-21
Identities = 92/304 (30%), Positives = 128/304 (42%), Gaps = 65/304 (21%)
Query: 133 AKASGANYSFHKE-----SGRFQDVGPQAPVGSVYQKTNAVSEIKRVGKDSFWAKAEKEE 187
+K G Y K+ + F+DV V S YQKT V + +K
Sbjct: 266 SKGFGGKYGVQKDRMDKNASTFEDV---TQVSSAYQKTVPVEAVT--------SKTSNIR 314
Query: 188 ENRRLEEKRRAEEAQRQLEQERRERELREAARREQRYQEQGGEASPQSRTWEQQQEVVSR 247
N K + +E +R+ E ER +R +E
Sbjct: 315 ANFENLAKEKEQEDRRKAEAERAQRMAKE------------------------------- 343
Query: 248 NRNEQESAVHPREIFKQKERAMSTTSISSPQPGKLRSPFLQKQLTQPETHFGREPAAAIS 307
R EQE A R +++ RA + T SP P P ++ + P E AA+
Sbjct: 344 -RQEQEEA---RRKLEEQARAKTQTPPVSPAP----QPTEERLPSSPVY----EDAASF- 390
Query: 308 RPRADLPAEEPAPSTPPCLVQAEEEAVYEEPPEQETFYEQPPLVQQQGAGSEHI--DHHI 365
+A+L P T P V + E A Y E Q+ V + H +
Sbjct: 391 --KAELSYRGPVSGTEPEPVYSMEAADYREASSQQGLAYATEAVYESAEAPGHYPAEDST 448
Query: 366 QGQGLSGQGLCARALYDYQAADDTEISFDPENLITGIEVIDEGWWRGYGPDGHFGMFPAN 425
+ + G+ A ALYDYQAA D EISFDP+++IT IE+ID+GWWRG G +G+FPAN
Sbjct: 449 YDEYENDLGITAVALYDYQAAGDDEISFDPDDIITNIEMIDDGWWRGV-CKGRYGLFPAN 507
Query: 426 YVEL 429
YVEL
Sbjct: 508 YVEL 511
>gi|5453710 LIM and SH3 protein 1 [Homo sapiens]
Length = 261
Score = 64.3 bits (155), Expect = 2e-10
Identities = 61/207 (29%), Positives = 86/207 (41%), Gaps = 21/207 (10%)
Query: 232 SPQSRTWEQQQEVVSRNRNEQESAVHPREIFKQKERAMSTTSISSPQPG----KLRSPFL 287
+P++ +QQ E+ S+ R ++E + + F I Q K F
Sbjct: 68 TPENLRLKQQSELQSQVRYKEEFEKNKGKGFSVVADTPELQRIKKTQDQISNIKYHEEF- 126
Query: 288 QKQLTQPETHFGREPAAAISRPRADL--PAEEPAPSTPPCLVQAEEEAVYEEPPEQETFY 345
+K P G EP S+ + P E+ P P VY++P +Q
Sbjct: 127 EKSRMGPSGGEGMEPERRDSQDGSSYRRPLEQQQPHHIPT-----SAPVYQQPQQQ---- 177
Query: 346 EQPPLVQQQGAGSEHIDH-HIQGQGLSGQGLCARALYDYQAADDTEISFDPENLITGIEV 404
P+ Q G E IQ G G RA+YDY AAD+ E+SF + I ++
Sbjct: 178 ---PVAQSYGGYKEPAAPVSIQRSAPGGGGKRYRAVYDYSAADEDEVSFQDGDTIVNVQQ 234
Query: 405 IDEGWWRG-YGPDGHFGMFPANYVELI 430
ID+GW G G GM PANYVE I
Sbjct: 235 IDDGWMYGTVERTGDTGMLPANYVEAI 261
>gi|194294523 intersectin 2 isoform 3 [Homo sapiens]
Length = 1670
Score = 63.9 bits (154), Expect = 3e-10
Identities = 64/273 (23%), Positives = 114/273 (41%), Gaps = 34/273 (12%)
Query: 175 GKDSFWA---KAEKEEENRRLEEKRRAEEAQRQLEQERRERELREAARREQRYQEQGGEA 231
GK++ W + E+EE+ +RL+E++ E+ Q E+ER+ E + + + +E+ E
Sbjct: 672 GKENLWKENLRKEEEEKQKRLQEEKTQEKIQ---EEERKAEEKQRKDKDTLKAEEKKRET 728
Query: 232 SPQSRTWEQQQEVVSRNRNEQESAVHPREIFKQKERAMSTTSISSPQPGKLRSPF----- 286
+ + +RN +E + + +I + E+ + +PG L F
Sbjct: 729 ASVLVNYRALYPFEARNHDEM--SFNSGDIIQVDEKTVG-------EPGWLYGSFQGNFG 779
Query: 287 -----LQKQLTQPETHFGREPAAAISRPRADLPA----EEPAPSTPPCLVQAEEEAVYEE 337
+++ E P A+ P L A EP S P V + +
Sbjct: 780 WFPCNYVEKMPSSENEKAVSPKKALLPPTVSLSATSTSSEPLSSNQPASVTDYQNVSFSN 839
Query: 338 PPEQETFYEQPPLVQQQGAGSEHIDHHIQGQGLSGQGLCARALYDYQAADDTEISFDPEN 397
++ ++ + GS H GQG + L A+AL + A D ++F +
Sbjct: 840 LTVNTSWQKKSAFTRTVSPGSVSPIH---GQGQVVENLKAQALCSWTAKKDNHLNFSKHD 896
Query: 398 LITGIEVIDEGWWRGYGPDGHFGMFPANYVELI 430
+IT +E E WW G G G FP +YV++I
Sbjct: 897 IITVLEQ-QENWWFGEVHGGR-GWFPKSYVKII 927
Score = 44.7 bits (104), Expect = 2e-04
Identities = 21/51 (41%), Positives = 32/51 (62%), Gaps = 1/51 (1%)
Query: 379 ALYDYQAADDTEISFDPENLITGIEVIDEGWWRGYGPDGHFGMFPANYVEL 429
A+YDY A ++ E+SF LI + D WW+G +G G+FP+NYV++
Sbjct: 1107 AMYDYAANNEDELSFSKGQLINVMNKDDPDWWQG-EINGVTGLFPSNYVKM 1156
Score = 42.0 bits (97), Expect = 0.001
Identities = 27/86 (31%), Positives = 47/86 (54%), Gaps = 2/86 (2%)
Query: 182 KAEKEEENRRLEEKRRAEEAQRQLEQERR-ERELREAARREQRYQEQGGEASPQ-SRTWE 239
KA E N LE++R+A Q+Q E ER+ ++E E R+++ QEQ + + + E
Sbjct: 368 KANYERGNMELEKRRQALMEQQQREAERKAQKEKEEWERKQRELQEQEWKKQLELEKRLE 427
Query: 240 QQQEVVSRNRNEQESAVHPREIFKQK 265
+Q+E+ + E+ + RE KQ+
Sbjct: 428 KQRELERQREEERRKDIERREAAKQE 453
Score = 40.4 bits (93), Expect = 0.003
Identities = 33/117 (28%), Positives = 63/117 (53%), Gaps = 11/117 (9%)
Query: 184 EKEEENRRLEEKRRAEEAQRQLEQERRERELREAARREQRYQEQGGEASPQSRTWE--QQ 241
+++E ++LE ++R E+ QR+LE++R E ++ RRE QE + + WE ++
Sbjct: 412 QEQEWKKQLELEKRLEK-QRELERQREEERRKDIERREAAKQELERQ---RRLEWERIRR 467
Query: 242 QEVVSRNRNEQESAVHPREIFKQKERAMSTTSISSPQ---PGKLRSPFLQKQLTQPE 295
QE++++ EQE V R K+K + +++ G+L+ L+KQ + E
Sbjct: 468 QELLNQKNREQEEIV--RLNSKKKNLHLELEALNGKHQQISGRLQDVRLKKQTQKTE 522
Score = 36.2 bits (82), Expect = 0.059
Identities = 24/85 (28%), Positives = 46/85 (54%), Gaps = 11/85 (12%)
Query: 180 WAKAEKEEENRRL----EEKRRAEEAQRQLEQERREREL-----REAARREQRYQE--QG 228
+ K ++EE ++L E+KR+A + +E E+R + L REA R+ Q+ +E +
Sbjct: 347 YQKMQEEEPQKKLPVTFEDKRKANYERGNMELEKRRQALMEQQQREAERKAQKEKEEWER 406
Query: 229 GEASPQSRTWEQQQEVVSRNRNEQE 253
+ Q + W++Q E+ R ++E
Sbjct: 407 KQRELQEQEWKKQLELEKRLEKQRE 431
Score = 32.3 bits (72), Expect = 0.85
Identities = 17/52 (32%), Positives = 27/52 (51%), Gaps = 4/52 (7%)
Query: 383 YQAADDTEISFDPENLITGIEVIDEGWWRG----YGPDGHFGMFPANYVELI 430
Y A+ ++S P LI ++ GWW+G G G FPA++V+L+
Sbjct: 1037 YVASGSEQLSLAPGQLILILKKNTSGWWQGELQARGKKRQKGWFPASHVKLL 1088
>gi|194294521 intersectin 2 isoform 1 [Homo sapiens]
Length = 1697
Score = 63.9 bits (154), Expect = 3e-10
Identities = 64/273 (23%), Positives = 114/273 (41%), Gaps = 34/273 (12%)
Query: 175 GKDSFWA---KAEKEEENRRLEEKRRAEEAQRQLEQERRERELREAARREQRYQEQGGEA 231
GK++ W + E+EE+ +RL+E++ E+ Q E+ER+ E + + + +E+ E
Sbjct: 699 GKENLWKENLRKEEEEKQKRLQEEKTQEKIQ---EEERKAEEKQRKDKDTLKAEEKKRET 755
Query: 232 SPQSRTWEQQQEVVSRNRNEQESAVHPREIFKQKERAMSTTSISSPQPGKLRSPF----- 286
+ + +RN +E + + +I + E+ + +PG L F
Sbjct: 756 ASVLVNYRALYPFEARNHDEM--SFNSGDIIQVDEKTVG-------EPGWLYGSFQGNFG 806
Query: 287 -----LQKQLTQPETHFGREPAAAISRPRADLPA----EEPAPSTPPCLVQAEEEAVYEE 337
+++ E P A+ P L A EP S P V + +
Sbjct: 807 WFPCNYVEKMPSSENEKAVSPKKALLPPTVSLSATSTSSEPLSSNQPASVTDYQNVSFSN 866
Query: 338 PPEQETFYEQPPLVQQQGAGSEHIDHHIQGQGLSGQGLCARALYDYQAADDTEISFDPEN 397
++ ++ + GS H GQG + L A+AL + A D ++F +
Sbjct: 867 LTVNTSWQKKSAFTRTVSPGSVSPIH---GQGQVVENLKAQALCSWTAKKDNHLNFSKHD 923
Query: 398 LITGIEVIDEGWWRGYGPDGHFGMFPANYVELI 430
+IT +E E WW G G G FP +YV++I
Sbjct: 924 IITVLEQ-QENWWFGEVHGGR-GWFPKSYVKII 954
Score = 44.7 bits (104), Expect = 2e-04
Identities = 21/51 (41%), Positives = 32/51 (62%), Gaps = 1/51 (1%)
Query: 379 ALYDYQAADDTEISFDPENLITGIEVIDEGWWRGYGPDGHFGMFPANYVEL 429
A+YDY A ++ E+SF LI + D WW+G +G G+FP+NYV++
Sbjct: 1134 AMYDYAANNEDELSFSKGQLINVMNKDDPDWWQG-EINGVTGLFPSNYVKM 1183
Score = 42.0 bits (97), Expect = 0.001
Identities = 27/86 (31%), Positives = 47/86 (54%), Gaps = 2/86 (2%)
Query: 182 KAEKEEENRRLEEKRRAEEAQRQLEQERR-ERELREAARREQRYQEQGGEASPQ-SRTWE 239
KA E N LE++R+A Q+Q E ER+ ++E E R+++ QEQ + + + E
Sbjct: 368 KANYERGNMELEKRRQALMEQQQREAERKAQKEKEEWERKQRELQEQEWKKQLELEKRLE 427
Query: 240 QQQEVVSRNRNEQESAVHPREIFKQK 265
+Q+E+ + E+ + RE KQ+
Sbjct: 428 KQRELERQREEERRKDIERREAAKQE 453
Score = 40.4 bits (93), Expect = 0.003
Identities = 33/117 (28%), Positives = 63/117 (53%), Gaps = 11/117 (9%)
Query: 184 EKEEENRRLEEKRRAEEAQRQLEQERRERELREAARREQRYQEQGGEASPQSRTWE--QQ 241
+++E ++LE ++R E+ QR+LE++R E ++ RRE QE + + WE ++
Sbjct: 412 QEQEWKKQLELEKRLEK-QRELERQREEERRKDIERREAAKQELERQ---RRLEWERIRR 467
Query: 242 QEVVSRNRNEQESAVHPREIFKQKERAMSTTSISSPQ---PGKLRSPFLQKQLTQPE 295
QE++++ EQE V R K+K + +++ G+L+ L+KQ + E
Sbjct: 468 QELLNQKNREQEEIV--RLNSKKKNLHLELEALNGKHQQISGRLQDVRLKKQTQKTE 522
Score = 36.2 bits (82), Expect = 0.059
Identities = 24/85 (28%), Positives = 46/85 (54%), Gaps = 11/85 (12%)
Query: 180 WAKAEKEEENRRL----EEKRRAEEAQRQLEQERREREL-----REAARREQRYQE--QG 228
+ K ++EE ++L E+KR+A + +E E+R + L REA R+ Q+ +E +
Sbjct: 347 YQKMQEEEPQKKLPVTFEDKRKANYERGNMELEKRRQALMEQQQREAERKAQKEKEEWER 406
Query: 229 GEASPQSRTWEQQQEVVSRNRNEQE 253
+ Q + W++Q E+ R ++E
Sbjct: 407 KQRELQEQEWKKQLELEKRLEKQRE 431
Score = 32.3 bits (72), Expect = 0.85
Identities = 17/52 (32%), Positives = 27/52 (51%), Gaps = 4/52 (7%)
Query: 383 YQAADDTEISFDPENLITGIEVIDEGWWRG----YGPDGHFGMFPANYVELI 430
Y A+ ++S P LI ++ GWW+G G G FPA++V+L+
Sbjct: 1064 YVASGSEQLSLAPGQLILILKKNTSGWWQGELQARGKKRQKGWFPASHVKLL 1115
>gi|194294525 intersectin 2 isoform 2 [Homo sapiens]
Length = 1249
Score = 63.9 bits (154), Expect = 3e-10
Identities = 64/273 (23%), Positives = 114/273 (41%), Gaps = 34/273 (12%)
Query: 175 GKDSFWA---KAEKEEENRRLEEKRRAEEAQRQLEQERRERELREAARREQRYQEQGGEA 231
GK++ W + E+EE+ +RL+E++ E+ Q E+ER+ E + + + +E+ E
Sbjct: 699 GKENLWKENLRKEEEEKQKRLQEEKTQEKIQ---EEERKAEEKQRKDKDTLKAEEKKRET 755
Query: 232 SPQSRTWEQQQEVVSRNRNEQESAVHPREIFKQKERAMSTTSISSPQPGKLRSPF----- 286
+ + +RN +E + + +I + E+ + +PG L F
Sbjct: 756 ASVLVNYRALYPFEARNHDEM--SFNSGDIIQVDEKTVG-------EPGWLYGSFQGNFG 806
Query: 287 -----LQKQLTQPETHFGREPAAAISRPRADLPA----EEPAPSTPPCLVQAEEEAVYEE 337
+++ E P A+ P L A EP S P V + +
Sbjct: 807 WFPCNYVEKMPSSENEKAVSPKKALLPPTVSLSATSTSSEPLSSNQPASVTDYQNVSFSN 866
Query: 338 PPEQETFYEQPPLVQQQGAGSEHIDHHIQGQGLSGQGLCARALYDYQAADDTEISFDPEN 397
++ ++ + GS H GQG + L A+AL + A D ++F +
Sbjct: 867 LTVNTSWQKKSAFTRTVSPGSVSPIH---GQGQVVENLKAQALCSWTAKKDNHLNFSKHD 923
Query: 398 LITGIEVIDEGWWRGYGPDGHFGMFPANYVELI 430
+IT +E E WW G G G FP +YV++I
Sbjct: 924 IITVLEQ-QENWWFGEVHGGR-GWFPKSYVKII 954
Score = 44.7 bits (104), Expect = 2e-04
Identities = 21/51 (41%), Positives = 32/51 (62%), Gaps = 1/51 (1%)
Query: 379 ALYDYQAADDTEISFDPENLITGIEVIDEGWWRGYGPDGHFGMFPANYVEL 429
A+YDY A ++ E+SF LI + D WW+G +G G+FP+NYV++
Sbjct: 1134 AMYDYAANNEDELSFSKGQLINVMNKDDPDWWQG-EINGVTGLFPSNYVKM 1183
Score = 42.0 bits (97), Expect = 0.001
Identities = 27/86 (31%), Positives = 47/86 (54%), Gaps = 2/86 (2%)
Query: 182 KAEKEEENRRLEEKRRAEEAQRQLEQERR-ERELREAARREQRYQEQGGEASPQ-SRTWE 239
KA E N LE++R+A Q+Q E ER+ ++E E R+++ QEQ + + + E
Sbjct: 368 KANYERGNMELEKRRQALMEQQQREAERKAQKEKEEWERKQRELQEQEWKKQLELEKRLE 427
Query: 240 QQQEVVSRNRNEQESAVHPREIFKQK 265
+Q+E+ + E+ + RE KQ+
Sbjct: 428 KQRELERQREEERRKDIERREAAKQE 453
Score = 40.4 bits (93), Expect = 0.003
Identities = 33/117 (28%), Positives = 63/117 (53%), Gaps = 11/117 (9%)
Query: 184 EKEEENRRLEEKRRAEEAQRQLEQERRERELREAARREQRYQEQGGEASPQSRTWE--QQ 241
+++E ++LE ++R E+ QR+LE++R E ++ RRE QE + + WE ++
Sbjct: 412 QEQEWKKQLELEKRLEK-QRELERQREEERRKDIERREAAKQELERQ---RRLEWERIRR 467
Query: 242 QEVVSRNRNEQESAVHPREIFKQKERAMSTTSISSPQ---PGKLRSPFLQKQLTQPE 295
QE++++ EQE V R K+K + +++ G+L+ L+KQ + E
Sbjct: 468 QELLNQKNREQEEIV--RLNSKKKNLHLELEALNGKHQQISGRLQDVRLKKQTQKTE 522
Score = 36.2 bits (82), Expect = 0.059
Identities = 24/85 (28%), Positives = 46/85 (54%), Gaps = 11/85 (12%)
Query: 180 WAKAEKEEENRRL----EEKRRAEEAQRQLEQERREREL-----REAARREQRYQE--QG 228
+ K ++EE ++L E+KR+A + +E E+R + L REA R+ Q+ +E +
Sbjct: 347 YQKMQEEEPQKKLPVTFEDKRKANYERGNMELEKRRQALMEQQQREAERKAQKEKEEWER 406
Query: 229 GEASPQSRTWEQQQEVVSRNRNEQE 253
+ Q + W++Q E+ R ++E
Sbjct: 407 KQRELQEQEWKKQLELEKRLEKQRE 431
Score = 32.3 bits (72), Expect = 0.85
Identities = 17/52 (32%), Positives = 27/52 (51%), Gaps = 4/52 (7%)
Query: 383 YQAADDTEISFDPENLITGIEVIDEGWWRG----YGPDGHFGMFPANYVELI 430
Y A+ ++S P LI ++ GWW+G G G FPA++V+L+
Sbjct: 1064 YVASGSEQLSLAPGQLILILKKNTSGWWQGELQARGKKRQKGWFPASHVKLL 1115
>gi|78042577 MAP7 domain containing 1 [Homo sapiens]
Length = 841
Score = 60.5 bits (145), Expect = 3e-09
Identities = 45/143 (31%), Positives = 73/143 (51%), Gaps = 10/143 (6%)
Query: 181 AKAEKEEENRRLEEKRRAEEAQRQLEQERRERELREAARREQRYQEQGGEASPQSRTWEQ 240
A+AE+E E RR EE+ E+AQ + E++ R ++ +E A R + + + +Q
Sbjct: 642 ARAEREAEARRREEQEAREKAQAEQEEQERLQKQKEEAEARSREEAERQRLEREKHFQQQ 701
Query: 241 QQEVVSRNRNEQESAVHPR--EIFKQKERAMS---TTSISSPQPGKL---RSPFLQKQLT 292
+QE R + +E R E+ + K++ S + SSP+P K RSP LQK+
Sbjct: 702 EQERQERRKRLEEIMKRTRKSEVSETKQKQDSKEANANGSSPEPVKAVEARSPGLQKEAV 761
Query: 293 QPETHFGREPAAAISRPRADLPA 315
Q E +EP ++ P +LPA
Sbjct: 762 QKEEPIPQEPQWSL--PSKELPA 782
Score = 37.7 bits (86), Expect = 0.020
Identities = 24/89 (26%), Positives = 48/89 (53%), Gaps = 6/89 (6%)
Query: 170 EIKRVGKDSFWAKAEKEEENRRLEEKRRAEEAQRQLEQERRERELREAARR--EQRYQEQ 227
E+K+ G+ AK +EE + L K+ + + + RE++L+E RR EQR + +
Sbjct: 131 EVKKAGERHKLAKERREERAKYLAAKKAVWLEKEEKAKALREKQLQERRRRLEEQRLKAE 190
Query: 228 GGEASPQSRTWEQQQEVVSRNRNEQESAV 256
A+ + E+Q++ + +N+ E+A+
Sbjct: 191 QRRAALE----ERQRQKLEKNKERYEAAI 215
Score = 28.9 bits (63), Expect = 9.4
Identities = 27/111 (24%), Positives = 46/111 (41%), Gaps = 11/111 (9%)
Query: 219 RREQRYQEQGGEASPQSRTWE----QQQEVVSRNR-NEQESAVHPREIFKQKERAMSTTS 273
R E+R GG +P R E Q++E + R NE+E + RE +K +++ +
Sbjct: 388 RGERRKPNAGGSPAPVRRRPEASPVQKKEKKDKERENEKEKSALARERSLKKRQSLPAS- 446
Query: 274 ISSPQPGKLRSPFLQKQLTQPETHFGREPAAAISRPRADLPAEEPAPSTPP 324
P S +L+ P+ + RP + P+ P + PP
Sbjct: 447 -----PRARLSASTASELSPKSKARPSSPSTSWHRPASPCPSPGPGHTLPP 492
>gi|102467235 inner centromere protein antigens 135/155kDa isoform 1
[Homo sapiens]
Length = 918
Score = 57.4 bits (137), Expect = 2e-08
Identities = 38/136 (27%), Positives = 62/136 (45%), Gaps = 2/136 (1%)
Query: 184 EKEEENRRLEEKRRAEEAQRQLEQERRERELREAARREQRYQEQGGEASPQSRTWEQQQE 243
+KEEE RL + A+ Q EQERRE+E RE RREQ +EQ E Q R +Q+
Sbjct: 667 KKEEEQERLRKAAEAKRLAEQREQERREQERREQERREQERREQ--ERREQERQLAEQER 724
Query: 244 VVSRNRNEQESAVHPREIFKQKERAMSTTSISSPQPGKLRSPFLQKQLTQPETHFGREPA 303
+ R + E + RE + ++ + + + + ++QL + + +E A
Sbjct: 725 RREQERLQAERELQEREKALRLQKEQLQRELEEKKKKEEQQRLAERQLQEEQEKKAKEAA 784
Query: 304 AAISRPRADLPAEEPA 319
A + + PA
Sbjct: 785 GASKALNVTVDVQSPA 800
Score = 41.6 bits (96), Expect = 0.001
Identities = 23/106 (21%), Positives = 56/106 (52%), Gaps = 1/106 (0%)
Query: 163 QKTNAVSEIKRVGKDSFWAKAEKEEENRRLEEKRRAEEAQRQLEQERRERELREAARREQ 222
++ +E KR+ + + E+E + E+ R E+ +R+ E++ E+E R R Q
Sbjct: 673 ERLRKAAEAKRLAEQREQERREQERREQERREQERREQERREQERQLAEQERRREQERLQ 732
Query: 223 RYQE-QGGEASPQSRTWEQQQEVVSRNRNEQESAVHPREIFKQKER 267
+E Q E + + + + Q+E+ + + E++ + R++ +++E+
Sbjct: 733 AERELQEREKALRLQKEQLQRELEEKKKKEEQQRLAERQLQEEQEK 778
Score = 38.9 bits (89), Expect = 0.009
Identities = 24/86 (27%), Positives = 45/86 (52%), Gaps = 4/86 (4%)
Query: 182 KAEKEEENRRLEEKRRAEEAQRQLEQERRERELREAARREQRYQEQGGEASPQSRTWEQQ 241
K EK +E R EEK + + A +++E+ R+ E ARR + Q++ E Q +++
Sbjct: 609 KTEKAKEERLAEEKAKKKAAAKKMEEVEARRKQEEEARRLRWLQQEEEERRHQELLQKKK 668
Query: 242 QEVVSRNRNEQESAVHPREIFKQKER 267
+E R R E+ + + +Q+E+
Sbjct: 669 EEEQERLRKAAEA----KRLAEQREQ 690
Score = 35.4 bits (80), Expect = 0.10
Identities = 43/196 (21%), Positives = 84/196 (42%), Gaps = 35/196 (17%)
Query: 186 EEENRRLEEKRRAEEAQ------------RQLEQE--RRERELREAARREQRYQEQGGEA 231
E+E +RLE RR EEA+ R+LE+ +RE LR+ + +R ++ E
Sbjct: 536 EKERQRLENLRRKEEAEQLRRQKVEEDKRRRLEEVKLKREERLRKVLQARERVEQMKEEK 595
Query: 232 SPQ---------SRTWEQQQEVVSRNRNEQESAVHPREIF----KQKERAMSTTSISSPQ 278
Q +T + ++E ++ + ++++A E KQ+E A + +
Sbjct: 596 KKQIEQKFAQIDEKTEKAKEERLAEEKAKKKAAAKKMEEVEARRKQEEEARRLRWLQQEE 655
Query: 279 PGKLRSPFLQKQLTQPETHFGREPAAAISRPRADLPAEEPAPSTPPCLVQAEEEAVYEEP 338
+ LQK+ + + + AA ++ A+ +E + E+E +E
Sbjct: 656 EERRHQELLQKKKEEEQERLRK---AAEAKRLAEQREQERREQE-----RREQERREQER 707
Query: 339 PEQETFYEQPPLVQQQ 354
EQE ++ L +Q+
Sbjct: 708 REQERREQERQLAEQE 723
>gi|102467242 inner centromere protein antigens 135/155kDa isoform 2
[Homo sapiens]
Length = 914
Score = 57.4 bits (137), Expect = 2e-08
Identities = 38/136 (27%), Positives = 62/136 (45%), Gaps = 2/136 (1%)
Query: 184 EKEEENRRLEEKRRAEEAQRQLEQERRERELREAARREQRYQEQGGEASPQSRTWEQQQE 243
+KEEE RL + A+ Q EQERRE+E RE RREQ +EQ E Q R +Q+
Sbjct: 663 KKEEEQERLRKAAEAKRLAEQREQERREQERREQERREQERREQ--ERREQERQLAEQER 720
Query: 244 VVSRNRNEQESAVHPREIFKQKERAMSTTSISSPQPGKLRSPFLQKQLTQPETHFGREPA 303
+ R + E + RE + ++ + + + + ++QL + + +E A
Sbjct: 721 RREQERLQAERELQEREKALRLQKEQLQRELEEKKKKEEQQRLAERQLQEEQEKKAKEAA 780
Query: 304 AAISRPRADLPAEEPA 319
A + + PA
Sbjct: 781 GASKALNVTVDVQSPA 796
Score = 41.6 bits (96), Expect = 0.001
Identities = 23/106 (21%), Positives = 56/106 (52%), Gaps = 1/106 (0%)
Query: 163 QKTNAVSEIKRVGKDSFWAKAEKEEENRRLEEKRRAEEAQRQLEQERRERELREAARREQ 222
++ +E KR+ + + E+E + E+ R E+ +R+ E++ E+E R R Q
Sbjct: 669 ERLRKAAEAKRLAEQREQERREQERREQERREQERREQERREQERQLAEQERRREQERLQ 728
Query: 223 RYQE-QGGEASPQSRTWEQQQEVVSRNRNEQESAVHPREIFKQKER 267
+E Q E + + + + Q+E+ + + E++ + R++ +++E+
Sbjct: 729 AERELQEREKALRLQKEQLQRELEEKKKKEEQQRLAERQLQEEQEK 774
Score = 38.9 bits (89), Expect = 0.009
Identities = 24/86 (27%), Positives = 45/86 (52%), Gaps = 4/86 (4%)
Query: 182 KAEKEEENRRLEEKRRAEEAQRQLEQERRERELREAARREQRYQEQGGEASPQSRTWEQQ 241
K EK +E R EEK + + A +++E+ R+ E ARR + Q++ E Q +++
Sbjct: 605 KTEKAKEERLAEEKAKKKAAAKKMEEVEARRKQEEEARRLRWLQQEEEERRHQELLQKKK 664
Query: 242 QEVVSRNRNEQESAVHPREIFKQKER 267
+E R R E+ + + +Q+E+
Sbjct: 665 EEEQERLRKAAEA----KRLAEQREQ 686
Score = 37.4 bits (85), Expect = 0.027
Identities = 44/197 (22%), Positives = 85/197 (43%), Gaps = 35/197 (17%)
Query: 185 KEEENRRLEEKRRAEEAQ------------RQLEQE--RRERELREAARREQRYQEQGGE 230
KE+E +RLE RR EEA+ R+LE+ +RE LR+ + +R ++ E
Sbjct: 531 KEKERQRLENLRRKEEAEQLRRQKVEEDKRRRLEEVKLKREERLRKVLQARERVEQMKEE 590
Query: 231 ASPQ---------SRTWEQQQEVVSRNRNEQESAVHPREIF----KQKERAMSTTSISSP 277
Q +T + ++E ++ + ++++A E KQ+E A +
Sbjct: 591 KKKQIEQKFAQIDEKTEKAKEERLAEEKAKKKAAAKKMEEVEARRKQEEEARRLRWLQQE 650
Query: 278 QPGKLRSPFLQKQLTQPETHFGREPAAAISRPRADLPAEEPAPSTPPCLVQAEEEAVYEE 337
+ + LQK+ + + + AA ++ A+ +E + E+E +E
Sbjct: 651 EEERRHQELLQKKKEEEQERLRK---AAEAKRLAEQREQERREQE-----RREQERREQE 702
Query: 338 PPEQETFYEQPPLVQQQ 354
EQE ++ L +Q+
Sbjct: 703 RREQERREQERQLAEQE 719
>gi|115527120 nebulin [Homo sapiens]
Length = 6669
Score = 56.2 bits (134), Expect = 6e-08
Identities = 30/61 (49%), Positives = 35/61 (57%), Gaps = 1/61 (1%)
Query: 371 SGQGLCARALYDYQAADDTEISFDPENLITGIEVIDEGWWRG-YGPDGHFGMFPANYVEL 429
S G RA+YDY AAD E+SF + I ++ IDEGW G G GM PANYVE
Sbjct: 6609 STAGKIFRAMYDYMAADADEVSFKDGDAIINVQAIDEGWMYGTVQRTGRTGMLPANYVEA 6668
Query: 430 I 430
I
Sbjct: 6669 I 6669
>gi|47087157 nebulette non-muscle isoform [Homo sapiens]
Length = 270
Score = 55.5 bits (132), Expect = 9e-08
Identities = 52/215 (24%), Positives = 87/215 (40%), Gaps = 29/215 (13%)
Query: 232 SPQSRTWEQQQEVVSRNRNEQESAVHPREIFKQKERAMSTTSISSPQPGKLRSPFLQKQL 291
+P++ +QQ E+ Q + R+ + K R S + +P+ +L+ Q+Q+
Sbjct: 68 TPENLRLKQQSEL-------QSQVKYKRDFEESKGRGFSIVT-DTPELQRLKRT--QEQI 117
Query: 292 TQPETHFGREPAAAIS-RPRADLPAEEPAPSTPPCLVQAEEEAVYEEPPEQETFYEQPPL 350
+ + H E P D P E + A + V+ E + +P +
Sbjct: 118 SNVKYHEDFEKTKGRGFTPVVDDPVTERVRKNTQVVSDAAYKGVHPHIVEMD---RRPGI 174
Query: 351 VQQQGAGSEHIDHHIQGQGLSGQGLCA--------------RALYDYQAADDTEISFDPE 396
+ + H QG G Q + RA+YDY A D+ E+SF
Sbjct: 175 IVAPVLPGAYQQSHSQGYGYMHQTSVSSMRSMQHSPNLRTYRAMYDYSAQDEDEVSFRDG 234
Query: 397 NLITGIEVIDEGWWRG-YGPDGHFGMFPANYVELI 430
+ I ++ ID+GW G G GM PANY+E +
Sbjct: 235 DYIVNVQPIDDGWMYGTVQRTGRTGMLPANYIEFV 269
>gi|4506931 SH3-domain GRB2-like 2 [Homo sapiens]
Length = 352
Score = 53.1 bits (126), Expect = 5e-07
Identities = 24/55 (43%), Positives = 34/55 (61%), Gaps = 1/55 (1%)
Query: 376 CARALYDYQAADDTEISFDPENLITGIEVIDEGWWRGYGPDGHFGMFPANYVELI 430
C RALYD++ ++ E+ F ++IT IDE W+ G GH G FP NYVE++
Sbjct: 294 CCRALYDFEPENEGELGFKEGDIITLTNQIDENWYEGM-LHGHSGFFPINYVEIL 347
>gi|5453758 nebulette sarcomeric isoform [Homo sapiens]
Length = 1014
Score = 52.8 bits (125), Expect = 6e-07
Identities = 24/54 (44%), Positives = 33/54 (61%), Gaps = 1/54 (1%)
Query: 378 RALYDYQAADDTEISFDPENLITGIEVIDEGWWRG-YGPDGHFGMFPANYVELI 430
RA+YDY A D+ E+SF + I ++ ID+GW G G GM PANY+E +
Sbjct: 960 RAMYDYSAQDEDEVSFRDGDYIVNVQPIDDGWMYGTVQRTGRTGMLPANYIEFV 1013
>gi|148747351 protein kinase C and casein kinase substrate in
neurons 2 [Homo sapiens]
Length = 486
Score = 52.8 bits (125), Expect = 6e-07
Identities = 27/62 (43%), Positives = 39/62 (62%), Gaps = 1/62 (1%)
Query: 371 SGQGLCARALYDYQAADDTEISFDPENLITGIEVIDE-GWWRGYGPDGHFGMFPANYVEL 429
SG + RALYDY+ + E+SF + +T +E DE GW +G +G G++PANYVE
Sbjct: 425 SGTEVRVRALYDYEGQEHDELSFKAGDELTKMEDEDEQGWCKGRLDNGQVGLYPANYVEA 484
Query: 430 IE 431
I+
Sbjct: 485 IQ 486
>gi|4507249 signal transducing adaptor molecule 1 [Homo sapiens]
Length = 540
Score = 52.0 bits (123), Expect = 1e-06
Identities = 22/55 (40%), Positives = 36/55 (65%), Gaps = 1/55 (1%)
Query: 373 QGLCARALYDYQAADDTEISFDPENLITGIEVIDEGWWRGYGPDGHFGMFPANYV 427
+G RA+YD++AA+D E++F +IT ++ D WW+G G G+FP+N+V
Sbjct: 211 EGRKVRAIYDFEAAEDNELTFKAGEIITVLDDSDPNWWKGETHQG-IGLFPSNFV 264
>gi|48255891 protein kinase C substrate 80K-H isoform 2 [Homo
sapiens]
Length = 525
Score = 51.6 bits (122), Expect = 1e-06
Identities = 47/201 (23%), Positives = 84/201 (41%), Gaps = 20/201 (9%)
Query: 180 WAKAEKEEENRRLEEKRRAEEAQRQLEQERRERELREAARREQRYQEQGGEASPQSRTWE 239
W KA +E++ + +E + + + Q+E R +E E RE + Q Q + WE
Sbjct: 148 WKKAREEKQKKLIELQAGKKSLEDQVEMLRTVKEEAEKPEREAKEQHQ--------KLWE 199
Query: 240 QQQEVVSRNRNEQESAVHPREIFKQKERAMSTTSISS-PQ-----PGKLRSPFLQKQL-- 291
+Q + ++ +A +E+ + +S T + + P+ G L Q L
Sbjct: 200 EQLAAAKAQQEQELAADAFKELDDDMDGTVSVTELQTHPELDTDGDGALSEAEAQALLSG 259
Query: 292 ---TQPETHFGREPAAAISRPRAD-LPAEEPAPSTPPCLVQAEEEAVYEEPPEQETFYEQ 347
T + + R AA + R++ LP + PAPS P EE+ P +E E+
Sbjct: 260 DTQTDATSFYDRVWAAIRDKYRSEALPTDLPAPSAPDLTEPKEEQPPVPSSPTEEEEEEE 319
Query: 348 PPLVQQQGAGSEHIDHHIQGQ 368
++ E D +QG+
Sbjct: 320 EEEEEEAEEEEEEEDSEVQGE 340
>gi|15011979 Rho guanine nucleotide exchange factor 4 isoform a
[Homo sapiens]
Length = 690
Score = 51.2 bits (121), Expect = 2e-06
Identities = 51/194 (26%), Positives = 78/194 (40%), Gaps = 18/194 (9%)
Query: 239 EQQQEVVSRNRNEQESAVHPREIFKQKERAMSTTSISSPQPGKL--RSPFLQKQLTQPET 296
E+ Q + + E +H + K + T I+SP+ L RS L +
Sbjct: 72 EKTQRKKLQKQAHVERRLHIGAVHKDGVKCWRKTIITSPESLNLPRRSHPLSQSAPTGLN 131
Query: 297 HFGREPAAAISRPRADLPAEEPAPSTPPCLVQA-EEEAVYEEPPEQETFYEQPPLVQQQG 355
H G P +P + A T C + EE +Y++ Y P G
Sbjct: 132 HMGWPEHT----PGTAMP--DGALDTAVCADEVGSEEDLYDDLHSSSHHYSHP------G 179
Query: 356 AGSEHIDHHIQGQGLSGQGLCARALYDYQAADDTEISFDPENLITGIEVIDEGWWRGYGP 415
G E + I G +CA AL+D+ DD E+ F ++I ++ + WW G
Sbjct: 180 GGGEQLA--INELISDGSVVCAEALWDHVTMDDQELGFKAGDVIEVMDATNREWWWGRVA 237
Query: 416 DGHFGMFPANYVEL 429
DG G FPA++V L
Sbjct: 238 DGE-GWFPASFVRL 250
>gi|15011981 Rho guanine nucleotide exchange factor 4 isoform b
[Homo sapiens]
Length = 670
Score = 51.2 bits (121), Expect = 2e-06
Identities = 51/194 (26%), Positives = 78/194 (40%), Gaps = 18/194 (9%)
Query: 239 EQQQEVVSRNRNEQESAVHPREIFKQKERAMSTTSISSPQPGKL--RSPFLQKQLTQPET 296
E+ Q + + E +H + K + T I+SP+ L RS L +
Sbjct: 72 EKTQRKKLQKQAHVERRLHIGAVHKDGVKCWRKTIITSPESLNLPRRSHPLSQSAPTGLN 131
Query: 297 HFGREPAAAISRPRADLPAEEPAPSTPPCLVQA-EEEAVYEEPPEQETFYEQPPLVQQQG 355
H G P +P + A T C + EE +Y++ Y P G
Sbjct: 132 HMGWPEHT----PGTAMP--DGALDTAVCADEVGSEEDLYDDLHSSSHHYSHP------G 179
Query: 356 AGSEHIDHHIQGQGLSGQGLCARALYDYQAADDTEISFDPENLITGIEVIDEGWWRGYGP 415
G E + I G +CA AL+D+ DD E+ F ++I ++ + WW G
Sbjct: 180 GGGEQLA--INELISDGSVVCAEALWDHVTMDDQELGFKAGDVIEVMDATNREWWWGRVA 237
Query: 416 DGHFGMFPANYVEL 429
DG G FPA++V L
Sbjct: 238 DGE-GWFPASFVRL 250
>gi|239745089 PREDICTED: golgi autoantigen, golgin subfamily a-like
[Homo sapiens]
Length = 828
Score = 50.8 bits (120), Expect = 2e-06
Identities = 43/208 (20%), Positives = 90/208 (43%), Gaps = 9/208 (4%)
Query: 170 EIKRVGKDSFWAKAEK---EEENRRLEEKRRAEEAQRQLEQERRERELREAARREQRYQE 226
E R +D W + EK +E+ +E+R E+ +R E+E R RE ++ ++E++ +E
Sbjct: 479 EKMREQEDQMWEQEEKMRDQEQKMWDQEERMWEQDERLREKEERMREQKKMWQQEEKMRE 538
Query: 227 QGGEASPQSRTWEQQQEV--VSRNRNEQESAVHPREIFKQKERAMSTTSISSPQPGKLRS 284
+ + +TW+Q++++ R R ++ E+ +++E M + +
Sbjct: 539 EKKTQEQEKKTWDQEEKMREEERMREREKKMREEEEMMREQEEKMQEQEEKMREQEEKMW 598
Query: 285 PFLQKQLTQPETHFGREPAAAISRPRADLPAEEPAPSTPPCLVQAEEEAVYEEP----PE 340
+K Q E + +E + +E +Q +EE ++E+ +
Sbjct: 599 EQEEKMQEQEEKMWEQEEKMWEQEEEDKMQEQEEMMWEQEEKMQEQEEKMWEQEEKMREQ 658
Query: 341 QETFYEQPPLVQQQGAGSEHIDHHIQGQ 368
+E EQ +Q Q + +QGQ
Sbjct: 659 EEKMREQEEKMQGQEEKMREQEEKMQGQ 686
Score = 47.0 bits (110), Expect = 3e-05
Identities = 44/188 (23%), Positives = 82/188 (43%), Gaps = 20/188 (10%)
Query: 182 KAEKEEENRRLEEKRRAEEAQRQLEQERRERELREAARREQRYQEQGGEASPQSRTWEQQ 241
K ++EE R +EKR E+ + EQE+ RE ++ +E++ QEQ + Q +Q
Sbjct: 270 KMREQEEKMRRQEKRLREQEKELREQEKELREQKKLREQEEQMQEQEEKMWEQEEKMREQ 329
Query: 242 QEVVSRNRN---EQESAVHPRE--IFKQKERAMSTTSISSPQPGKLRSPFLQKQLTQPET 296
+E + R EQE + +E + Q+ER + ++R Q+++ + E
Sbjct: 330 EEKMWRQEERLWEQEKQMREQEQKMRDQEERMWEQDERLREKEERMRE---QEKMWEQEE 386
Query: 297 HFGREPAAAISRPRADLPAEEPAPSTPPCLVQAEEEAVYEE----------PPEQETFYE 346
E I + EE +Q +EE ++E+ P ++E +E
Sbjct: 387 KMQEE--ERIREREKKMREEEETMREQEEKMQKQEENMWEQEEKEWQQQRLPEQKEKLWE 444
Query: 347 QPPLVQQQ 354
Q + +Q+
Sbjct: 445 QEKMQEQE 452
Score = 43.1 bits (100), Expect = 5e-04
Identities = 42/193 (21%), Positives = 86/193 (44%), Gaps = 18/193 (9%)
Query: 176 KDSFWAKAEKEEENRRL--------EEKRRAEEAQRQLEQERRERELREAARREQRYQEQ 227
+++ W + EKE + +RL E+++ E+ ++ EQE + R+ E +E++ Q
Sbjct: 419 EENMWEQEEKEWQQQRLPEQKEKLWEQEKMQEQEEKIWEQEEKIRDQEEMWGQEKKMWRQ 478
Query: 228 GGEASPQSRTWEQQQEVVSRNR---NEQESAVHPREIFKQKERAMSTTSISSPQPGKLRS 284
+ + WEQ++++ + + +++E E ++KE M Q K+R
Sbjct: 479 EKMREQEDQMWEQEEKMRDQEQKMWDQEERMWEQDERLREKEERMREQKKMWQQEEKMRE 538
Query: 285 PFL---QKQLTQPETHFGREPAAAISRPRADLPAEEPAPSTPPCLVQAEEEAVYEEPPEQ 341
Q++ T + RE R + + EE +Q +EE + E ++
Sbjct: 539 EKKTQEQEKKTWDQEEKMREEERMREREK-KMREEEEMMREQEEKMQEQEEKMRE---QE 594
Query: 342 ETFYEQPPLVQQQ 354
E +EQ +Q+Q
Sbjct: 595 EKMWEQEEKMQEQ 607
Score = 42.7 bits (99), Expect = 6e-04
Identities = 42/179 (23%), Positives = 78/179 (43%), Gaps = 20/179 (11%)
Query: 184 EKEEENRRLEEKRRAEEAQRQLEQERRERELREAARREQRYQEQGGEASPQSRTWEQQQE 243
++EE+ R EE+ R +E + + ++E+ R+ + +E+ +EQ E Q + EQ+++
Sbjct: 252 KQEEKMWRQEERLREQEGKMREQEEKMRRQEKRLREQEKELREQEKELREQKKLREQEEQ 311
Query: 244 VVSRNRN--EQESAVHPRE--IFKQKERAMSTTSISSPQPGKLRSPFLQKQLTQPETHFG 299
+ + EQE + +E +++Q+ER Q K+R Q++ +
Sbjct: 312 MQEQEEKMWEQEEKMREQEEKMWRQEERLWEQEKQMREQEQKMRD---QEERMWEQDERL 368
Query: 300 REPAAAISRPRADLPAEEPAPSTPPCLVQAEEEAVYEEP----PEQETFYEQPPLVQQQ 354
RE + EE EEE + E E+ET EQ +Q+Q
Sbjct: 369 REKEERMREQEKMWEQEEK---------MQEEERIREREKKMREEEETMREQEEKMQKQ 418
Score = 40.0 bits (92), Expect = 0.004
Identities = 18/85 (21%), Positives = 48/85 (56%), Gaps = 4/85 (4%)
Query: 182 KAEKEEENRRLEEKRRAEEAQRQLEQERRERELREAARREQRYQEQGGEASPQSRTWEQQ 241
K +EEE R +E++ ++ + EQE +E + + ++++ EQ + + WEQ+
Sbjct: 400 KMREEEETMREQEEKMQKQEENMWEQEEKEWQQQRLPEQKEKLWEQEKMQEQEEKIWEQE 459
Query: 242 QEVVSRNRNEQESAVHPREIFKQKE 266
+++ R+++E +++++Q++
Sbjct: 460 EKI----RDQEEMWGQEKKMWRQEK 480
Score = 36.6 bits (83), Expect = 0.045
Identities = 22/92 (23%), Positives = 51/92 (55%), Gaps = 8/92 (8%)
Query: 176 KDSFWAKAEKEEENRRLEEKRRAEEAQRQLEQERRERELREAARREQRYQEQGGEASPQS 235
++ W + EK +E R+ E+ E+ R+ E+ RE+E + ++E+ EQ + Q
Sbjct: 378 QEKMWEQEEKMQEEERIRER---EKKMREEEETMREQE-EKMQKQEENMWEQEEKEWQQQ 433
Query: 236 RTWEQQQEVVSRNRNEQESAVHPREIFKQKER 267
R EQ++++ + + +++ +I++Q+E+
Sbjct: 434 RLPEQKEKLWEQEKMQEQE----EKIWEQEEK 461
Score = 36.6 bits (83), Expect = 0.045
Identities = 22/84 (26%), Positives = 46/84 (54%), Gaps = 6/84 (7%)
Query: 184 EKEEENRRLEEKRRAEEAQRQLEQER-RERELREAARREQRYQEQGGEASPQSRTWEQQQ 242
E+EE+ R EEK R +E + Q ++E+ RE+E + + E+ +++ + + W Q++
Sbjct: 650 EQEEKMREQEEKMREQEEKMQGQEEKMREQEEKMQGQEEKMREQEEKMRGQEEKMWGQEE 709
Query: 243 EVVSRNRNEQESAVHPREIFKQKE 266
++ QE + +E ++KE
Sbjct: 710 KMWG-----QEEKMWGQEEMREKE 728
Score = 36.2 bits (82), Expect = 0.059
Identities = 34/145 (23%), Positives = 67/145 (46%), Gaps = 16/145 (11%)
Query: 163 QKTNAVSEIKRVGKDSFWAKAEKEEENRRLEEK--RRAEEAQRQLEQERRERELREAARR 220
+K E R ++ W E+EE+ + EEK + E+ Q E+++ + + +
Sbjct: 581 EKMQEQEEKMREQEEKMW---EQEEKMQEQEEKMWEQEEKMWEQEEEDKMQEQEEMMWEQ 637
Query: 221 EQRYQEQGGEASPQSRTWEQQQEVVSRNR--NEQESAVHPRE--IFKQKERAMSTTSISS 276
E++ QEQ + + WEQ++++ + EQE + +E + +Q+E+
Sbjct: 638 EEKMQEQ------EEKMWEQEEKMREQEEKMREQEEKMQGQEEKMREQEEKMQGQEEKMR 691
Query: 277 PQPGKLRSPFLQKQLTQPETHFGRE 301
Q K+R +K Q E +G+E
Sbjct: 692 EQEEKMRGQ-EEKMWGQEEKMWGQE 715
Score = 35.8 bits (81), Expect = 0.077
Identities = 52/252 (20%), Positives = 109/252 (43%), Gaps = 30/252 (11%)
Query: 131 KVAKASGANYSFHKESGRF-QDVGPQAPVGSV--YQKTNAVSEIKRVGKDSF----WAKA 183
++ +A A ++HK++ R+ +++ + S+ Y+ T E+K+ + A++
Sbjct: 142 ELQRALSAVSTWHKKADRYIEELTKERDALSLELYRNTITNEELKKKNAELQEKLRLAES 201
Query: 184 EKEEENRRLEE-KRRAEEAQRQLEQERRERELREAARREQRYQEQGGEASPQ-SRTWEQQ 241
EK E ++E KR+ E A+ L Q + E R+E+ +EQ + Q + W Q+
Sbjct: 202 EKSEIQLNVKELKRKLERAKFLLPQVQTNTLQEEMWRQEEELREQEKKIRKQEEKMWRQE 261
Query: 242 Q---EVVSRNRNEQESAVHPREIFKQKERAMSTTSISSPQPGKLRSPFLQKQLTQPETHF 298
+ E + R ++E + +++E+ + + KLR ++Q+ + E
Sbjct: 262 ERLREQEGKMREQEEKMRRQEKRLREQEKELREQEKELREQKKLREQ--EEQMQEQEEKM 319
Query: 299 G------REPAAAISRPRADLPAEEPAPSTPPCLVQAEEEAVYEEPP----------EQE 342
RE + R L +E ++ +EE ++E+ EQE
Sbjct: 320 WEQEEKMREQEEKMWRQEERLWEQEKQMREQEQKMRDQEERMWEQDERLREKEERMREQE 379
Query: 343 TFYEQPPLVQQQ 354
+EQ +Q++
Sbjct: 380 KMWEQEEKMQEE 391
Score = 33.9 bits (76), Expect = 0.29
Identities = 21/105 (20%), Positives = 52/105 (49%), Gaps = 7/105 (6%)
Query: 170 EIKRVGKDSFWAKAEK---EEENRRLEEKRRAEEAQRQLEQERRERE----LREAARREQ 222
E R ++ W + E+ +E+ R +E++ ++ +R EQ+ R RE +RE + +
Sbjct: 324 EKMREQEEKMWRQEERLWEQEKQMREQEQKMRDQEERMWEQDERLREKEERMREQEKMWE 383
Query: 223 RYQEQGGEASPQSRTWEQQQEVVSRNRNEQESAVHPREIFKQKER 267
+ ++ E + R + ++E + E++ +++Q+E+
Sbjct: 384 QEEKMQEEERIREREKKMREEEETMREQEEKMQKQEENMWEQEEK 428
Score = 33.9 bits (76), Expect = 0.29
Identities = 43/187 (22%), Positives = 79/187 (42%), Gaps = 28/187 (14%)
Query: 182 KAEKEEENRRLEEKRRAEEAQRQLEQERRERELREAARREQRYQEQGGEASPQSRTWEQQ 241
K +K+EEN +E++ ++ QR EQ+ + E + +E++ EQ + Q W Q+
Sbjct: 414 KMQKQEENMWEQEEKEWQQ-QRLPEQKEKLWEQEKMQEQEEKIWEQEEKIRDQEEMWGQE 472
Query: 242 QEVVSRNR-NEQESAVHPRE---------IFKQKERAMSTTSISSPQPGKLRSPFLQKQL 291
+++ + + EQE + +E ++ Q+ER + ++R QK++
Sbjct: 473 KKMWRQEKMREQEDQMWEQEEKMRDQEQKMWDQEERMWEQDERLREKEERMRE---QKKM 529
Query: 292 TQPETHFGREPAAAISRPRADLPAEEPAPSTPPCLVQAEEEAVYEEP----PEQETFYEQ 347
Q E RE + + EE EEE + E E+E EQ
Sbjct: 530 WQQEEKM-REEKKTQEQEKKTWDQEEK---------MREEERMREREKKMREEEEMMREQ 579
Query: 348 PPLVQQQ 354
+Q+Q
Sbjct: 580 EEKMQEQ 586
Score = 33.9 bits (76), Expect = 0.29
Identities = 31/125 (24%), Positives = 60/125 (48%), Gaps = 15/125 (12%)
Query: 184 EKEEENRRLEEK-RRAEEAQRQLEQERRERELREAARREQRYQEQGGEASPQSRTWEQQQ 242
E+EE R EEK + EE R+ E++ E+E + + E+ +++ + + WEQ++
Sbjct: 571 EEEEMMREQEEKMQEQEEKMREQEEKMWEQEEKMQEQEEKMWEQ-------EEKMWEQEE 623
Query: 243 EVVSRNRN----EQESAVHPRE--IFKQKERAMSTTSISSPQPGKLRSPFLQKQLTQPET 296
E + + EQE + +E +++Q+E+ Q K++ +K Q E
Sbjct: 624 EDKMQEQEEMMWEQEEKMQEQEEKMWEQEEKMREQEEKMREQEEKMQGQ-EEKMREQEEK 682
Query: 297 HFGRE 301
G+E
Sbjct: 683 MQGQE 687
Score = 33.1 bits (74), Expect = 0.50
Identities = 20/73 (27%), Positives = 42/73 (57%), Gaps = 3/73 (4%)
Query: 184 EKEEENRRLEEKRRAEEAQRQLEQER-RERELREAARREQRYQEQGGEASPQSRTW--EQ 240
E+EE+ + EEK R +E + Q ++E+ RE+E + + E+ + ++ + + W E+
Sbjct: 664 EQEEKMQGQEEKMREQEEKMQGQEEKMREQEEKMRGQEEKMWGQEEKMWGQEEKMWGQEE 723
Query: 241 QQEVVSRNRNEQE 253
+E R R+++E
Sbjct: 724 MREKEERIRDQKE 736
>gi|24308229 protein kinase C and casein kinase substrate in neurons
1 [Homo sapiens]
Length = 444
Score = 50.8 bits (120), Expect = 2e-06
Identities = 26/59 (44%), Positives = 35/59 (59%), Gaps = 1/59 (1%)
Query: 373 QGLCARALYDYQAADDTEISFDPENLITGIEVIDE-GWWRGYGPDGHFGMFPANYVELI 430
+G+ RALYDY + E+SF + +T + DE GW RG G G++PANYVE I
Sbjct: 386 KGVRVRALYDYDGQEQDELSFKAGDELTKLGEEDEQGWCRGRLDSGQLGLYPANYVEAI 444
>gi|148746195 trichohyalin [Homo sapiens]
Length = 1943
Score = 50.1 bits (118), Expect = 4e-06
Identities = 40/161 (24%), Positives = 74/161 (45%), Gaps = 6/161 (3%)
Query: 182 KAEKEEENRRLEEKRRAEEAQRQLEQERRERELREAARREQRYQEQGGEASPQSRTWEQQ 241
+ E++EE ++ + RR ++ +R+ E+ERRE++ E R +Q +EQ E Q EQ+
Sbjct: 287 RRERQEEEQQQQRLRREQQLRRKQEEERREQQ--EERREQQERREQQEERREQQLRREQE 344
Query: 242 QEVVSRNRNEQESAVHPREIFKQKERAMSTTSISSPQPGKLRSPFLQKQLTQPETHFGRE 301
+ + R EQE +++ +++E + Q + ++Q + E RE
Sbjct: 345 ERREQQLRREQEEERREQQLRREQEEERREQQLRREQQLRREQQLRREQQLRREQQLRRE 404
Query: 302 PAAAISRPRADLPAEEPAPSTPPCLVQAEEEAVYEEPPEQE 342
R L E+ L + +EE +E+ EQE
Sbjct: 405 QQL---RREQQLRREQQLRREQQ-LRREQEEERHEQKHEQE 441
Score = 47.8 bits (112), Expect = 2e-05
Identities = 53/210 (25%), Positives = 86/210 (40%), Gaps = 43/210 (20%)
Query: 180 WAKAEKEEENRRLEEKRRAEEAQRQLEQERRERELR--------------------EAAR 219
W K +EEE R E++RR ++ +R E+ERRER L+ + R
Sbjct: 457 WLK--REEETERHEQERRKQQLKRDQEEERRERWLKLEEEERREQQERREQQLRREQEER 514
Query: 220 REQRYQEQGGEASPQSRTWEQQQEVVSRNRNEQESAVHPREIFKQKERAMSTTSISSPQP 279
REQR + Q E Q R +QQ + R + E+ + RE K+ E+ + Q
Sbjct: 515 REQRLKRQEEEERLQQRLRSEQQ--LRREQEERREQLLKREEEKRLEQERREQRLKREQE 572
Query: 280 GKLRSPFLQKQLTQPETHFGREPAAAI---------------SRPRADLPAEEPAPSTPP 324
+ R L+++ + + RE + R L EEP
Sbjct: 573 ER-RDQLLKREEERRQQRLKREQEERLEQRLKREEVERLEQEERREQRLKREEPEEERRQ 631
Query: 325 CLVQAEEEAVYEEPPEQETFYEQPPLVQQQ 354
L+++EE+ EE +Q+ EQ +Q+
Sbjct: 632 QLLKSEEQ---EERRQQQLRREQQERREQR 658
Score = 47.4 bits (111), Expect = 3e-05
Identities = 44/190 (23%), Positives = 84/190 (44%), Gaps = 10/190 (5%)
Query: 163 QKTNAVSEIKRVGKDSFWAKAEKEEENRRLEEKRRAEEAQRQLEQERRERELR------- 215
Q+ +++R ++ + +++EE RL+++ R+E+ R+ ++ERRE+ L+
Sbjct: 499 QQERREQQLRREQEERREQRLKRQEEEERLQQRLRSEQQLRREQEERREQLLKREEEKRL 558
Query: 216 EAARREQRYQEQGGEASPQ--SRTWEQQQEVVSRNRNEQ-ESAVHPREIFKQKERAMSTT 272
E RREQR + + E Q R E++Q+ + R + E+ E + E+ + ++
Sbjct: 559 EQERREQRLKREQEERRDQLLKREEERRQQRLKREQEERLEQRLKREEVERLEQEERREQ 618
Query: 273 SISSPQPGKLRSPFLQKQLTQPETHFGREPAAAISRPRADLPAEEPAPSTPPCLVQAEEE 332
+ +P + R L K Q E + R L EE L + EE
Sbjct: 619 RLKREEPEEERRQQLLKSEEQEERRQQQLRREQQERREQRLKREEEEERLEQRLKREHEE 678
Query: 333 AVYEEPPEQE 342
E+ +E
Sbjct: 679 ERREQELAEE 688
Score = 47.0 bits (110), Expect = 3e-05
Identities = 42/172 (24%), Positives = 70/172 (40%), Gaps = 14/172 (8%)
Query: 185 KEEENRRLEEKRRAEEAQRQLEQERRERELREAARREQRYQ-----EQGGEASPQSRTWE 239
K E+ RLE++ + EE +R ++ERRE+ L+ E+R Q E+ E Q E
Sbjct: 591 KREQEERLEQRLKREEVERLEQEERREQRLKREEPEEERRQQLLKSEEQEERRQQQLRRE 650
Query: 240 QQQEVVSRNRNEQESAVHPREIFKQKERAMSTTSISSPQPGKLRSPF---LQKQLTQPET 296
QQ+ R + E+E + + ++ E ++ + + R + K Q E+
Sbjct: 651 QQERREQRLKREEEEERLEQRLKREHEEERREQELAEEEQEQARERIKSRIPKWQWQLES 710
Query: 297 HFGREPAAAISRPRAD------LPAEEPAPSTPPCLVQAEEEAVYEEPPEQE 342
+ SRPR EE L EEE + + E+E
Sbjct: 711 EADARQSKVYSRPRKQEGQRRRQEQEEKRRRRESELQWQEEERAHRQQQEEE 762
Score = 46.2 bits (108), Expect = 6e-05
Identities = 48/182 (26%), Positives = 80/182 (43%), Gaps = 16/182 (8%)
Query: 182 KAEKEEENRRLEEKRRAEEAQRQLEQERRERELREAARREQRYQEQGGEASPQSRTWEQQ 241
+ E+E+ R+ +E++ EE Q Q E+E+ RE RE RR++R ++ + Q + E+Q
Sbjct: 915 REEREKRRRQEQERQYREEEQLQQEEEQLLREEREKRRRQERERQYRKDKKLQQK--EEQ 972
Query: 242 ---QEVVSRNRNEQESAVHPREIFKQKERAMSTTSISSPQPGKLRSPFLQK-QLTQPETH 297
+E R R E+E E +Q+E + + + + +K +L Q E
Sbjct: 973 LLGEEPEKRRRQEREKKYREEEELQQEEEQLLREEREKRRRQEWERQYRKKDELQQEEEQ 1032
Query: 298 FGREPAAAISRPRADLPAEEPAPSTPPCLVQAEEEAVYEE-----PPEQETFYEQPPLVQ 352
RE R + L E L Q EE+ + EE E E Y + +Q
Sbjct: 1033 LLRE-----EREKRRLQERERQYREEEELQQEEEQLLGEERETRRRQELERQYRKEEELQ 1087
Query: 353 QQ 354
Q+
Sbjct: 1088 QE 1089
Score = 45.8 bits (107), Expect = 7e-05
Identities = 37/122 (30%), Positives = 55/122 (45%), Gaps = 6/122 (4%)
Query: 180 WAKAEKEEENRRLEEKRRAEEAQRQLEQERRERELREAARREQRYQEQGGEASPQSRTWE 239
W K +E R+ EEK + EE QRQ E + E +LR+ R+E R + Q E Q E
Sbjct: 246 WRK--RETVLRKEEEKLQEEEPQRQRELQEEEEQLRKLERQELRRERQEEEQQQQRLRRE 303
Query: 240 QQQEVVSRNRNEQESAVHPREIFKQKERAMSTTSISSPQPGKLRSPFLQKQLTQPETHFG 299
QQ R + E+E E +Q+ER Q + + ++QL + +
Sbjct: 304 QQ----LRRKQEEERREQQEERREQQERREQQEERREQQLRREQEERREQQLRREQEEER 359
Query: 300 RE 301
RE
Sbjct: 360 RE 361
Score = 45.1 bits (105), Expect = 1e-04
Identities = 49/186 (26%), Positives = 81/186 (43%), Gaps = 28/186 (15%)
Query: 184 EKEEENRRLEEKRRAEEAQRQLEQERRERE--------LREAARREQRYQEQGGEASPQS 235
++++E RR +E+RR ++ + QLE+ER+ R L+E R+EQ+ ++ E
Sbjct: 857 QEDQERRRSQEQRRDQKWRWQLEEERKRRRHTLYAKPALQEQLRKEQQLLQEEEEEL--- 913
Query: 236 RTWEQQQEVVSRNRNEQESAVHPREIFKQKERAMSTTSISSPQPGKLRSPFLQ-KQLTQP 294
Q++E R R EQE E +Q+E + + + + + K+L Q
Sbjct: 914 ----QREEREKRRRQEQERQYREEEQLQQEEEQLLREEREKRRRQERERQYRKDKKLQQK 969
Query: 295 ETH-FGREPAAAISRPRADLPAEEPAPSTPPCLVQAEEEAVYEE-----PPEQETFYEQP 348
E G EP + R EE L Q EE+ + EE E E Y +
Sbjct: 970 EEQLLGEEPEKRRRQEREKKYREEEE------LQQEEEQLLREEREKRRRQEWERQYRKK 1023
Query: 349 PLVQQQ 354
+QQ+
Sbjct: 1024 DELQQE 1029
Score = 44.7 bits (104), Expect = 2e-04
Identities = 42/160 (26%), Positives = 71/160 (44%), Gaps = 9/160 (5%)
Query: 192 LEEKRRAEEAQRQLEQERRERELREAARREQRYQEQGGEASPQSRTWEQQQEVVSRNRNE 251
L + RR EE QR+ E R+ E RR Q+ QEQ E + E+Q+ + R+R
Sbjct: 109 LLQDRRQEEDQRRFEPRDRQLEEEPGQRRRQKRQEQERELAEGEEQSEKQERLEQRDRQR 168
Query: 252 QESAV--HPREIFKQKERAMSTTSISSPQPGKLRSPFLQKQLTQPE----THFGREPAAA 305
++ + +E +++ER + S + + ++QL + E GRE
Sbjct: 169 RDEELWRQRQEWQEREERRAEEEQLQSCKGHETEEFPDEEQLRRRELLELRRKGREEKQQ 228
Query: 306 ISRPRAD---LPAEEPAPSTPPCLVQAEEEAVYEEPPEQE 342
R R D EE +++ EEE + EE P+++
Sbjct: 229 QRRERQDRVFQEEEEKEWRKRETVLRKEEEKLQEEEPQRQ 268
Score = 43.5 bits (101), Expect = 4e-04
Identities = 35/178 (19%), Positives = 79/178 (44%), Gaps = 9/178 (5%)
Query: 184 EKEEENRRLEEKRRAEEAQRQLEQERRERELREAARREQRYQEQGGEASPQSRTWEQQQE 243
E+E+ RR E +R+ + ++QL + RE++LR+ R+ R +EQ + R + ++++
Sbjct: 1378 EEEQRLRRQERERKFLKEEQQLRCQEREQQLRQDRDRKFREEEQQLSRQERDRKFREEEQ 1437
Query: 244 VVSRNRNEQESAVHPREIFKQKERAMSTTS--ISSPQPGKLRSPFLQKQLTQPETHFGRE 301
V R E++ +++ +++ R + + +L ++ + E R+
Sbjct: 1438 QVRRQERERKFLEEEQQLRQERHRKFREEEQLLQEREEQQLHRQERDRKFLEEEQQLRRQ 1497
Query: 302 PAAAISRPRADLPAEEPAPSTPPCLVQAEEEAVYEEPPEQETFYEQPPLVQQQGAGSE 359
R + +L ++EP EEE Q F ++ +++Q G +
Sbjct: 1498 ERDRKFREQ-ELRSQEPERKF------LEEEQQLHRQQRQRKFLQEEQQLRRQERGQQ 1548
Score = 42.0 bits (97), Expect = 0.001
Identities = 27/132 (20%), Positives = 65/132 (49%), Gaps = 3/132 (2%)
Query: 172 KRVGKDSFWAKAEKEEENRRLEEKRRAEEAQRQLEQERRERELR--EAARREQRYQEQGG 229
+R+ ++ + ++EE + EE+R +E +R+ ++ERRE++LR + RREQ+ + +
Sbjct: 298 QRLRREQQLRRKQEEERREQQEERREQQE-RREQQEERREQQLRREQEERREQQLRREQE 356
Query: 230 EASPQSRTWEQQQEVVSRNRNEQESAVHPREIFKQKERAMSTTSISSPQPGKLRSPFLQK 289
E + + +Q+E + +E + + +++++ + Q + ++
Sbjct: 357 EERREQQLRREQEEERREQQLRREQQLRREQQLRREQQLRREQQLRREQQLRREQQLRRE 416
Query: 290 QLTQPETHFGRE 301
Q + E RE
Sbjct: 417 QQLRREQQLRRE 428
Score = 41.2 bits (95), Expect = 0.002
Identities = 25/108 (23%), Positives = 53/108 (49%), Gaps = 1/108 (0%)
Query: 184 EKEEENRRLEEKR-RAEEAQRQLEQERRERELREAARREQRYQEQGGEASPQSRTWEQQQ 242
E+EE+ R+LE + R E + + +Q+R RE + ++E+ +EQ E Q EQQ+
Sbjct: 273 EEEEQLRKLERQELRRERQEEEQQQQRLRREQQLRRKQEEERREQQEERREQQERREQQE 332
Query: 243 EVVSRNRNEQESAVHPREIFKQKERAMSTTSISSPQPGKLRSPFLQKQ 290
E + ++ +++ +++E + Q + R L+++
Sbjct: 333 ERREQQLRREQEERREQQLRREQEEERREQQLRREQEEERREQQLRRE 380
Score = 41.2 bits (95), Expect = 0.002
Identities = 30/102 (29%), Positives = 51/102 (50%), Gaps = 15/102 (14%)
Query: 182 KAEKEEENRRLEEKRRAEEAQRQLEQERRERELR--EAARR-----EQRYQEQGGEASPQ 234
+ E+EE+ R +E+ R + QL QER E++LR E+ R+ + R + + + PQ
Sbjct: 1756 RPEREEQQLRRQERDRKFREEEQLRQEREEQQLRSQESDRKFREEEQLRQEREEQQLRPQ 1815
Query: 235 SR----TWEQQQ----EVVSRNRNEQESAVHPREIFKQKERA 268
R WE++Q E R R E++ E F +E++
Sbjct: 1816 QRDGKYRWEEEQLQLEEQEQRLRQERDRQYRAEEQFATQEKS 1857
Score = 40.4 bits (93), Expect = 0.003
Identities = 23/81 (28%), Positives = 47/81 (58%), Gaps = 1/81 (1%)
Query: 185 KEEENRRLEEKRRAEEAQRQLEQERRERELREAARREQRYQEQGGEASPQSRTWEQQQEV 244
+ E+ R E++ R E+ R+ +Q RRE++LR + E+R++++ + + R +Q+E
Sbjct: 396 RREQQLRREQQLRREQQLRREQQLRREQQLRR-EQEEERHEQKHEQERREQRLKREQEER 454
Query: 245 VSRNRNEQESAVHPREIFKQK 265
+ E+E+ H +E KQ+
Sbjct: 455 RDWLKREEETERHEQERRKQQ 475
Score = 40.4 bits (93), Expect = 0.003
Identities = 32/118 (27%), Positives = 52/118 (44%), Gaps = 13/118 (11%)
Query: 163 QKTNAVSEIKRVGKDSFWAKAEKEEENRRLEEKRRAEEAQRQLEQE-----------RRE 211
++T E++R + + E+E+ R EKRR +E +RQ +E R E
Sbjct: 1068 RETRRRQELERQYRKEEELQQEEEQLLREEPEKRRRQERERQCREEEELQQEEEQLLREE 1127
Query: 212 RELREAARREQRYQEQGGEASPQSRTWEQQQEVVSRNRNEQESAVHPREIFKQKERAM 269
RE R E++Y+E+ E Q ++E R R E E E +Q+E +
Sbjct: 1128 REKRRRQELERQYREE--EEVQQEEEQLLREEPEKRRRQELERQYREEEELQQEEEQL 1183
Score = 40.0 bits (92), Expect = 0.004
Identities = 28/107 (26%), Positives = 55/107 (51%), Gaps = 3/107 (2%)
Query: 185 KEEENRRLEEKRRAEEAQRQLEQERRERELR--EAARREQRY-QEQGGEASPQSRTWEQQ 241
+ E+ R E++ R E+ R+ +Q RRE++LR + RREQ+ +EQ E Q E++
Sbjct: 384 RREQQLRREQQLRREQQLRREQQLRREQQLRREQQLRREQQLRREQEEERHEQKHEQERR 443
Query: 242 QEVVSRNRNEQESAVHPREIFKQKERAMSTTSISSPQPGKLRSPFLQ 288
++ + R + E+ + E ++ E+ + Q + R +L+
Sbjct: 444 EQRLKREQEERRDWLKREEETERHEQERRKQQLKRDQEEERRERWLK 490
Score = 40.0 bits (92), Expect = 0.004
Identities = 41/124 (33%), Positives = 62/124 (50%), Gaps = 17/124 (13%)
Query: 182 KAEKEEENRRLEE---KRRAEEAQRQLEQERRERELREAARREQRYQEQGGEASPQSRTW 238
+ E+EE+ R ++ K R EE Q QLE+ +E+ LR+ R+ R +EQ +SR
Sbjct: 1804 RQEREEQQLRPQQRDGKYRWEEEQLQLEE--QEQRLRQERDRQYRAEEQFA-TQEKSRRE 1860
Query: 239 EQQ--QEVVSRNRNEQESAV---HPREIFKQKERAMSTTSISSPQPGKLRSPFLQKQLTQ 293
EQ+ QE + R E+E + H R K+++R I S Q GK +L +
Sbjct: 1861 EQELWQEEEQKRRQERERKLREEHIRRQQKEEQRHRQVGEIKS-QEGKGHG-----RLLE 1914
Query: 294 PETH 297
P TH
Sbjct: 1915 PGTH 1918
Score = 39.7 bits (91), Expect = 0.005
Identities = 30/97 (30%), Positives = 51/97 (52%), Gaps = 6/97 (6%)
Query: 163 QKTNAVSEIKRVGKDSFWAKAEKEEEN--RRLEEKRRAEEAQRQLEQERRERELR---EA 217
Q+ +++R ++ + E+ E RR +++ R E+ R+ ++ERRE++LR E
Sbjct: 298 QRLRREQQLRRKQEEERREQQEERREQQERREQQEERREQQLRREQEERREQQLRREQEE 357
Query: 218 ARREQRY-QEQGGEASPQSRTWEQQQEVVSRNRNEQE 253
RREQ+ +EQ E Q EQQ + R EQ+
Sbjct: 358 ERREQQLRREQEEERREQQLRREQQLRREQQLRREQQ 394
Score = 39.7 bits (91), Expect = 0.005
Identities = 28/86 (32%), Positives = 47/86 (54%), Gaps = 3/86 (3%)
Query: 185 KEEENRRLEEKRRAEEAQRQLEQERRERELR--EAARREQRY-QEQGGEASPQSRTWEQQ 241
+E+E R E++ R E+ R+ +Q RRE++LR + RREQ+ +EQ Q R +Q
Sbjct: 366 REQEEERREQQLRREQQLRREQQLRREQQLRREQQLRREQQLRREQQLRREQQLRREQQL 425
Query: 242 QEVVSRNRNEQESAVHPREIFKQKER 267
+ R+EQ+ RE ++E+
Sbjct: 426 RREQEEERHEQKHEQERREQRLKREQ 451
Score = 39.7 bits (91), Expect = 0.005
Identities = 29/116 (25%), Positives = 59/116 (50%), Gaps = 10/116 (8%)
Query: 163 QKTNAVSEIKRVGKDSFWAKAEKEEENRRLEEKRRAEEAQRQLEQERRERELREAARR-- 220
Q+ +++R ++ + ++EEE RLE++ + E + + EQE E E +A R
Sbjct: 639 QEERRQQQLRREQQERREQRLKREEEEERLEQRLKREHEEERREQELAEEEQEQARERIK 698
Query: 221 ----EQRYQEQGGEASPQSRTWEQ-QQEVVSRNRNEQESAVHPREI---FKQKERA 268
+ ++Q + + QS+ + + +++ R R EQE RE ++++ERA
Sbjct: 699 SRIPKWQWQLESEADARQSKVYSRPRKQEGQRRRQEQEEKRRRRESELQWQEEERA 754
Score = 39.7 bits (91), Expect = 0.005
Identities = 33/113 (29%), Positives = 55/113 (48%), Gaps = 12/113 (10%)
Query: 163 QKTNAVSEIKRVGKDSFWAKAEKEEENRRLEEKR-RAEEAQRQLEQ---ERRERELREAA 218
+K NAV + K + K + E+ R+LE+ + R ++Q+ L+ E++ER+ +
Sbjct: 1230 EKENAVRDNK------VYCKGRENEQFRQLEDSQLRDRQSQQDLQHLLGEQQERDREQER 1283
Query: 219 RREQRYQEQGGEASPQSRTWEQQQEVVSRNRNEQESAVHPREIFKQKERAMST 271
RR Q+ E R E+Q+E R+R QE RE ++K R T
Sbjct: 1284 RRWQQRDRHFPEEEQLER--EEQKEAKRRDRKSQEEKQLLREEREEKRRRQET 1334
Score = 38.9 bits (89), Expect = 0.009
Identities = 30/132 (22%), Positives = 66/132 (50%), Gaps = 13/132 (9%)
Query: 144 KESGRFQDVGPQAPVGSVYQKTNAVSEIKRVGKDSFWAKAEKEEEN----RRLEEKRRAE 199
KE + Q+ PQ + +++++ + + ++EE+ RR ++ RR +
Sbjct: 255 KEEEKLQEEEPQRQ----RELQEEEEQLRKLERQELRRERQEEEQQQQRLRREQQLRRKQ 310
Query: 200 EAQRQLEQ----ERRERELREAARREQRYQEQGGEASPQSRTWEQQQEVVSRN-RNEQES 254
E +R+ +Q E++ER ++ RREQ+ + + E Q EQ++E + R EQE
Sbjct: 311 EEERREQQEERREQQERREQQEERREQQLRREQEERREQQLRREQEEERREQQLRREQEE 370
Query: 255 AVHPREIFKQKE 266
+++ ++++
Sbjct: 371 ERREQQLRREQQ 382
Score = 38.9 bits (89), Expect = 0.009
Identities = 28/106 (26%), Positives = 52/106 (49%), Gaps = 1/106 (0%)
Query: 170 EIKRVGKDSFWAKAEKEEENRRLEEKRRAEEAQRQL-EQERRERELREAARREQRYQEQG 228
E++R ++ + E+E+ R EKRR +E +RQ E+E ++E + R EQ + Q
Sbjct: 1135 ELERQYREEEEVQQEEEQLLREEPEKRRRQELERQYREEEELQQEEEQLLREEQEKRRQE 1194
Query: 229 GEASPQSRTWEQQQEVVSRNRNEQESAVHPREIFKQKERAMSTTSI 274
E + Q+Q+ R R+E + + + +KE A+ +
Sbjct: 1195 RERQYREEEELQRQKRKQRYRDEDQRSDLKWQWEPEKENAVRDNKV 1240
Score = 38.9 bits (89), Expect = 0.009
Identities = 37/188 (19%), Positives = 82/188 (43%), Gaps = 27/188 (14%)
Query: 170 EIKRVGKDSFWAKAE---KEEENRRLEEKRRAEEAQRQLEQERRERELREAARREQRYQE 226
+++R +D + + E +E E + LEE+++ QRQ + + E++LR R +QR Q+
Sbjct: 1493 QLRRQERDRKFREQELRSQEPERKFLEEEQQLHRQQRQRKFLQEEQQLRRQERGQQRRQD 1552
Query: 227 QGGEASPQSRTWEQQQEVVSRNRNEQESAVHPREIFKQKERAMSTTSISSPQPGKLRSPF 286
+ R + +++++ +Q S F+ +E+ K+R
Sbjct: 1553 -------RDRKFREEEQLRQEREEQQLSRQERDRKFRLEEQ-------------KVRRQE 1592
Query: 287 LQKQLTQPETHFGREPAAAISRPRADLPAEEPAPSTPPCLVQAEEEAVYEEPPEQETFYE 346
+++ + E R+ R D E L + EE+ ++ + +++ E
Sbjct: 1593 QERKFMEDEQQLRRQEGQQQLRQERDRKFRE----DEQLLQEREEQQLHRQERDRKFLEE 1648
Query: 347 QPPLVQQQ 354
+P L +Q+
Sbjct: 1649 EPQLRRQE 1656
Score = 38.9 bits (89), Expect = 0.009
Identities = 24/91 (26%), Positives = 48/91 (52%), Gaps = 4/91 (4%)
Query: 182 KAEKEEENRRL---EEKRRAEEAQRQLEQERRERELREAARREQRYQEQGGEASPQSRTW 238
K ++E+ R+ E++ R +E Q+QL QE R+R+ RE + Q +EQ + R +
Sbjct: 1587 KVRRQEQERKFMEDEQQLRRQEGQQQLRQE-RDRKFREDEQLLQEREEQQLHRQERDRKF 1645
Query: 239 EQQQEVVSRNRNEQESAVHPREIFKQKERAM 269
+++ + R EQ+ F+++E+ +
Sbjct: 1646 LEEEPQLRRQEREQQLRHDRDRKFREEEQLL 1676
Score = 38.5 bits (88), Expect = 0.012
Identities = 43/191 (22%), Positives = 79/191 (41%), Gaps = 22/191 (11%)
Query: 170 EIKRVGKDSFWAKAEKEEENRRLEEKRRAEEAQRQLEQERR-----------ERELREAA 218
E +R ++ + E+E+ R EKRR +E +RQ ++++ E E R
Sbjct: 925 EQERQYREEEQLQQEEEQLLREEREKRRRQERERQYRKDKKLQQKEEQLLGEEPEKRRRQ 984
Query: 219 RREQRYQEQGGEASPQSRTWEQQQEVVSRNRNEQESAVHPREIFKQKERAMSTTSISSPQ 278
RE++Y+E+ E Q ++E R R E E ++ +Q+E + +
Sbjct: 985 EREKKYREE--EELQQEEEQLLREEREKRRRQEWERQYRKKDELQQEEEQLLREEREKRR 1042
Query: 279 PGKLRSPFLQKQLTQPETH--FGREPAAAISRPRADLPAEEPAPSTPPCLVQAEEEAVYE 336
+ + +++ Q E G E +R R +L + +Q EEE +
Sbjct: 1043 LQERERQYREEEELQQEEEQLLGEERE---TRRRQELERQYRKEEE----LQQEEEQLLR 1095
Query: 337 EPPEQETFYEQ 347
E PE+ E+
Sbjct: 1096 EEPEKRRRQER 1106
Score = 38.5 bits (88), Expect = 0.012
Identities = 38/181 (20%), Positives = 77/181 (42%), Gaps = 23/181 (12%)
Query: 180 WAKAEKEEENRRLEEKRRAEEAQRQLEQERRERELREAARREQRYQEQGGEASPQSRTWE 239
W + ++++ + EE++ E + + + RER+ RE E+ Q++ + + R
Sbjct: 1016 WERQYRKKDELQQEEEQLLREEREKRRLQERERQYRE----EEELQQEEEQLLGEERETR 1071
Query: 240 QQQEVVSRNRNEQESAVHPREIFKQKERAMSTTSISSPQPGKLRSPFLQKQLTQPETHFG 299
++QE+ + R E+ E+ +++E+ + + + R +++L Q E
Sbjct: 1072 RRQELERQYRKEE-------ELQQEEEQLLREEPEKRRRQERERQCREEEELQQEEEQLL 1124
Query: 300 REPAAAISRPRADLPAEEPAPSTPPCLVQAEEEAVYEEPPEQ------ETFYEQPPLVQQ 353
RE R + E VQ EEE + E PE+ E Y + +QQ
Sbjct: 1125 REEREKRRRQELERQYREEEE------VQQEEEQLLREEPEKRRRQELERQYREEEELQQ 1178
Query: 354 Q 354
+
Sbjct: 1179 E 1179
Score = 38.1 bits (87), Expect = 0.016
Identities = 42/197 (21%), Positives = 76/197 (38%), Gaps = 27/197 (13%)
Query: 182 KAEKEEENRRLEEKRRAEEAQRQLEQERRERELREAARREQRYQEQ-------------- 227
+ +++E+ R L E E Q +LEQ R+R E R+ Q +QE+
Sbjct: 138 RQKRQEQERELAEGEEQSEKQERLEQRDRQRRDEELWRQRQEWQEREERRAEEEQLQSCK 197
Query: 228 --GGEASPQSRTWEQQQEVVSRNRNEQESAVHPRE----IFKQKE----RAMSTTSISSP 277
E P +++ + R + +E RE +F+++E R T
Sbjct: 198 GHETEEFPDEEQLRRRELLELRRKGREEKQQQRRERQDRVFQEEEEKEWRKRETVLRKEE 257
Query: 278 QPGKLRSPFLQKQLTQPETHFGREPAAAISRPRADLPAEEPAPSTPPCLVQAEEEAVYEE 337
+ + P Q++L + E + + R R + ++ L + +EE E
Sbjct: 258 EKLQEEEPQRQRELQEEEEQLRKLERQELRRERQEEEQQQQRLRREQQLRRKQEE---ER 314
Query: 338 PPEQETFYEQPPLVQQQ 354
+QE EQ +QQ
Sbjct: 315 REQQEERREQQERREQQ 331
Score = 38.1 bits (87), Expect = 0.016
Identities = 27/88 (30%), Positives = 47/88 (53%), Gaps = 5/88 (5%)
Query: 185 KEEENRRLEEKRRAEEAQR---QLEQERRERELR--EAARREQRYQEQGGEASPQSRTWE 239
+E++ RR ++ RR +E +R + EQERRE+ L+ + RR+ +E+ E Q R +
Sbjct: 415 REQQLRREQQLRREQEEERHEQKHEQERREQRLKREQEERRDWLKREEETERHEQERRKQ 474
Query: 240 QQQEVVSRNRNEQESAVHPREIFKQKER 267
Q + R E+ + E +Q+ER
Sbjct: 475 QLKRDQEEERRERWLKLEEEERREQQER 502
Score = 38.1 bits (87), Expect = 0.016
Identities = 20/77 (25%), Positives = 43/77 (55%), Gaps = 1/77 (1%)
Query: 185 KEEENRRLEEKRRAEEAQRQL-EQERRERELREAARREQRYQEQGGEASPQSRTWEQQQE 243
+++E R +E+RR ++ R E+E+ ERE ++ A+R R ++ + + R +++++
Sbjct: 1273 EQQERDREQERRRWQQRDRHFPEEEQLEREEQKEAKRRDRKSQEEKQLLREEREEKRRRQ 1332
Query: 244 VVSRNRNEQESAVHPRE 260
R E+E + RE
Sbjct: 1333 ETDRKFREEEQLLQERE 1349
Score = 38.1 bits (87), Expect = 0.016
Identities = 28/128 (21%), Positives = 59/128 (46%), Gaps = 2/128 (1%)
Query: 172 KRVGKDSFWAKAEKEEENRRLEEKRRAEEAQRQLEQERRERELREAARREQRYQEQGGEA 231
++ +D + +E++ R E R+ E + QL ++ RE++LR R+ R +EQ +
Sbjct: 1619 RKFREDEQLLQEREEQQLHRQERDRKFLEEEPQLRRQEREQQLRHDRDRKFREEEQLLQE 1678
Query: 232 SPQSRTWEQQQEVVSRNRNEQESAVHPREIFKQKERAMSTTSISSP--QPGKLRSPFLQK 289
+ + Q+++ R +Q F Q+E+ + + + +LR Q+
Sbjct: 1679 GEEQQLRRQERDRKFREEEQQLRRQERERKFLQEEQQLRRQELERKFREEEQLRQETEQE 1738
Query: 290 QLTQPETH 297
QL + E +
Sbjct: 1739 QLRRQERY 1746
Score = 37.7 bits (86), Expect = 0.020
Identities = 46/191 (24%), Positives = 82/191 (42%), Gaps = 30/191 (15%)
Query: 143 HKESGRFQDVGPQAPVGSVYQKTNAVSEIK-RVGKDSFWAKAEKEEENRRLEEKRRAEEA 201
H+E R Q++ + ++ A IK R+ K + ++E + ++ + R +E
Sbjct: 676 HEEERREQELAEE-------EQEQARERIKSRIPKWQWQLESEADARQSKVYSRPRKQEG 728
Query: 202 QRQLEQE-----RRERELR----EAARREQRYQEQGGEASPQSRTWEQQQEVVSRNRNEQ 252
QR+ +++ RRE EL+ E A R+Q+ +EQ + TW+ Q E S ++
Sbjct: 729 QRRRQEQEEKRRRRESELQWQEEERAHRQQQEEEQ-----RRDFTWQWQAEEKSERGRQR 783
Query: 253 ESAVHPREIFKQKERAMSTTSISS------PQPGKLRSPFLQKQLTQPETHFGREPAAAI 306
SA P + +Q+ER + P+ + Q++ + E F E
Sbjct: 784 LSARPP--LREQRERQLRAEERQQREQRFLPEEEEKEQRRRQRREREKELQFLEEEEQLQ 841
Query: 307 SRPRADLPAEE 317
R RA EE
Sbjct: 842 RRERAQQLQEE 852
Score = 37.7 bits (86), Expect = 0.020
Identities = 22/86 (25%), Positives = 41/86 (47%)
Query: 182 KAEKEEENRRLEEKRRAEEAQRQLEQERRERELREAARREQRYQEQGGEASPQSRTWEQQ 241
K ++E R+ E+ ++ + QL +E E+ R+ R+ R +E+ + Q EQ+
Sbjct: 1130 KRRRQELERQYREEEEVQQEEEQLLREEPEKRRRQELERQYREEEELQQEEEQLLREEQE 1189
Query: 242 QEVVSRNRNEQESAVHPREIFKQKER 267
+ R R +E R+ KQ+ R
Sbjct: 1190 KRRQERERQYREEEELQRQKRKQRYR 1215
Score = 37.7 bits (86), Expect = 0.020
Identities = 39/174 (22%), Positives = 71/174 (40%), Gaps = 17/174 (9%)
Query: 184 EKEEENRRLEEKRRAEEAQRQLEQERRERELREAARREQRYQE---QGGEASPQSRTWEQ 240
E+EE+ R+++E ++ L +ER E+ R+ R+ R +E Q E P R
Sbjct: 1300 EREEQKEAKRRDRKSQEEKQLLREEREEKRRRQETDRKFREEEQLLQEREEQPLRRQERD 1359
Query: 241 QQEVVSRNRNEQESAVHPREIFKQKERAMSTTSISSPQPGKLRSPFLQKQLTQPETHFGR 300
++ R++++ E +Q+ R + +LR ++QL Q R
Sbjct: 1360 RKFREEELRHQEQGRKFLEE--EQRLRRQERERKFLKEEQQLRCQEREQQLRQDRDRKFR 1417
Query: 301 EPAAAISRPRADLPAEEPAPSTPPCLVQAEEEAVYEEPPEQETFYEQPPLVQQQ 354
E +SR D E EE+ V + E++ E+ L Q++
Sbjct: 1418 EEEQQLSRQERDRKFRE------------EEQQVRRQERERKFLEEEQQLRQER 1459
Score = 37.4 bits (85), Expect = 0.027
Identities = 22/93 (23%), Positives = 51/93 (54%), Gaps = 3/93 (3%)
Query: 170 EIKRVGKDSFWAKAEKEEENRRL--EEKRRAEEAQRQLEQERRERELREAARREQRYQEQ 227
E +++ +++ + ++E R++ EE+ R E ++QL ++ R+R+ RE + Q +EQ
Sbjct: 1727 EEEQLRQETEQEQLRRQERYRKILEEEQLRPEREEQQLRRQERDRKFREEEQLRQEREEQ 1786
Query: 228 GGEASPQSRTWEQQQEVVSRNRNEQESAVHPRE 260
+ R + +++E + + R EQ+ R+
Sbjct: 1787 QLRSQESDRKF-REEEQLRQEREEQQLRPQQRD 1818
Score = 37.0 bits (84), Expect = 0.035
Identities = 45/177 (25%), Positives = 76/177 (42%), Gaps = 18/177 (10%)
Query: 184 EKEEENRRLEEKRRAEEAQRQLEQERRERELREAARREQRYQEQGGEASPQSR-TWEQQQ 242
E+EE+ +R E ++ +E + L QE +ER + RR+Q+++ Q E + R T +
Sbjct: 835 EEEEQLQRRERAQQLQEEEDGL-QEDQERRRSQEQRRDQKWRWQLEEERKRRRHTLYAKP 893
Query: 243 EVVSRNRNEQESAVHPREIFKQKERAMSTTSISSPQPGKLRSPFLQKQLTQPETHFGREP 302
+ + R EQ+ E +++ER Q + ++QL Q E RE
Sbjct: 894 ALQEQLRKEQQLLQEEEEELQREEREKRRRQEQERQYRE------EEQLQQEEEQLLRE- 946
Query: 303 AAAISRPRADLPAEEPAPSTPPCLVQAEEEAVYEEP-----PEQETFYEQPPLVQQQ 354
R + E L Q EE+ + EEP E+E Y + +QQ+
Sbjct: 947 ----EREKRRRQERERQYRKDKKLQQKEEQLLGEEPEKRRRQEREKKYREEEELQQE 999
Score = 36.6 bits (83), Expect = 0.045
Identities = 36/171 (21%), Positives = 71/171 (41%), Gaps = 7/171 (4%)
Query: 184 EKEEENRRLEEKRRAEEAQRQLEQER----RERELREAARREQRYQEQGGEASPQSRTWE 239
E+E ++ E++RR + +R+ E+ R RE E + ++ Q + + + W
Sbjct: 430 EEERHEQKHEQERREQRLKREQEERRDWLKREEETERHEQERRKQQLKRDQEEERRERWL 489
Query: 240 QQQEVVSRNRNEQESAVHPREIFKQKERAMSTTSISSPQPGKLRS--PFLQKQLTQPETH 297
+ +E R + E+ RE +++E+ + +LRS ++Q + E
Sbjct: 490 KLEEEERREQQERREQQLRREQEERREQRLKRQEEEERLQQRLRSEQQLRREQEERREQL 549
Query: 298 FGREPAAAISRPRADLPAEEPAPSTPPCLVQAEEEAVYEE-PPEQETFYEQ 347
RE + + R + + L++ EEE + EQE EQ
Sbjct: 550 LKREEEKRLEQERREQRLKREQEERRDQLLKREEERRQQRLKREQEERLEQ 600
Score = 36.6 bits (83), Expect = 0.045
Identities = 21/86 (24%), Positives = 45/86 (52%), Gaps = 1/86 (1%)
Query: 182 KAEKEEENRRLEEKRRAEEAQRQLEQERRER-ELREAARREQRYQEQGGEASPQSRTWEQ 240
+ E+E + R EE ++ EE + E+E+R R EL R E+ Q++ + + +
Sbjct: 1103 RQERERQCREEEELQQEEEQLLREEREKRRRQELERQYREEEEVQQEEEQLLREEPEKRR 1162
Query: 241 QQEVVSRNRNEQESAVHPREIFKQKE 266
+QE+ + R E+E ++ ++++
Sbjct: 1163 RQELERQYREEEELQQEEEQLLREEQ 1188
Score = 36.6 bits (83), Expect = 0.045
Identities = 44/189 (23%), Positives = 76/189 (40%), Gaps = 31/189 (16%)
Query: 184 EKEEENRRLEEKRRAEEAQRQLEQER---------RERELREAARREQRYQEQGGEASPQ 234
E+ EE RR +E R + QL QER R+R+ RE E R+QEQG + +
Sbjct: 1323 EEREEKRRRQETDRKFREEEQLLQEREEQPLRRQERDRKFRE---EELRHQEQGRKFLEE 1379
Query: 235 SRTWEQQQEVVSRNRNEQESAVHPRE---------IFKQKERAMSTTSISSPQPGKLRSP 285
+ +Q+ + EQ+ RE F+++E+ +S + K R
Sbjct: 1380 EQRLRRQERERKFLKEEQQLRCQEREQQLRQDRDRKFREEEQQLS----RQERDRKFREE 1435
Query: 286 FLQKQLTQPETHFGREPAAAISRPRADLPAEEPAPSTPPCLVQAEEEAVYEEPPEQETFY 345
Q + + E F E EE L + EE+ ++ + +++
Sbjct: 1436 EQQVRRQERERKFLEEEQQLRQERHRKFREEE------QLLQEREEQQLHRQERDRKFLE 1489
Query: 346 EQPPLVQQQ 354
E+ L +Q+
Sbjct: 1490 EEQQLRRQE 1498
Score = 36.6 bits (83), Expect = 0.045
Identities = 27/124 (21%), Positives = 53/124 (42%), Gaps = 4/124 (3%)
Query: 182 KAEKEEENRRLEEKRRAEEAQRQLEQERRERELREAARREQRYQEQGGEASPQSRTWEQQ 241
+ ++ E R EE+ R E Q QL ++ R R++ E + +EQ + R + ++
Sbjct: 1717 RRQELERKFREEEQLRQETEQEQLRRQERYRKILEEEQLRPEREEQQLRRQERDRKFREE 1776
Query: 242 QEVVSRNRNEQESAVHPREIFKQKERAMSTTSISSPQP----GKLRSPFLQKQLTQPETH 297
+++ +Q + F+++E+ +P GK R Q QL + E
Sbjct: 1777 EQLRQEREEQQLRSQESDRKFREEEQLRQEREEQQLRPQQRDGKYRWEEEQLQLEEQEQR 1836
Query: 298 FGRE 301
+E
Sbjct: 1837 LRQE 1840
Score = 35.8 bits (81), Expect = 0.077
Identities = 50/211 (23%), Positives = 81/211 (38%), Gaps = 19/211 (9%)
Query: 163 QKTNAVSEIKRVGKDSF--WAKAEKEEENRRLEEKRRAEEAQRQLEQERRERELREAAR- 219
Q+ E KR ++S W + E+ ++ EE+RR Q Q E++ R +AR
Sbjct: 729 QRRRQEQEEKRRRRESELQWQEEERAHRQQQEEEQRRDFTWQWQAEEKSERGRQRLSARP 788
Query: 220 --REQRYQEQGGEASPQSRTW----EQQQEVVSRNRNEQESAVHPREIFKQKERAMSTTS 273
REQR ++ E Q E+++E R R E+E + E +Q +R
Sbjct: 789 PLREQRERQLRAEERQQREQRFLPEEEEKEQRRRQRREREKELQFLEEEEQLQRRERAQQ 848
Query: 274 ISSPQPGKLRSPFLQKQLTQPETHFGREPAAAISRPRADL----PAEEPAPSTPPCLVQA 329
+ + G ++ Q R + R PA + L+Q
Sbjct: 849 LQEEEDGLQEDQERRRSQEQRRDQKWRWQLEEERKRRRHTLYAKPALQEQLRKEQQLLQE 908
Query: 330 EEEAVYEEP------PEQETFYEQPPLVQQQ 354
EEE + E EQE Y + +QQ+
Sbjct: 909 EEEELQREEREKRRRQEQERQYREEEQLQQE 939
Score = 35.8 bits (81), Expect = 0.077
Identities = 22/86 (25%), Positives = 43/86 (50%)
Query: 182 KAEKEEENRRLEEKRRAEEAQRQLEQERRERELREAARREQRYQEQGGEASPQSRTWEQQ 241
+ E+E+ R+ E++ EE + Q E+E+ RE E RR++ ++ E Q +
Sbjct: 1125 REEREKRRRQELERQYREEEEVQQEEEQLLREEPEKRRRQELERQYREEEELQQEEEQLL 1184
Query: 242 QEVVSRNRNEQESAVHPREIFKQKER 267
+E + R E+E E ++++R
Sbjct: 1185 REEQEKRRQERERQYREEEELQRQKR 1210
Score = 35.4 bits (80), Expect = 0.10
Identities = 26/99 (26%), Positives = 49/99 (49%), Gaps = 11/99 (11%)
Query: 184 EKEEENRRLEEKRRAEEAQRQLEQERRERELR-----------EAARREQRYQEQGGEAS 232
E+E++ RR E +R+ + ++QL ++ ER+ R E RR++RY++ E
Sbjct: 1695 EEEQQLRRQERERKFLQEEQQLRRQELERKFREEEQLRQETEQEQLRRQERYRKILEEEQ 1754
Query: 233 PQSRTWEQQQEVVSRNRNEQESAVHPREIFKQKERAMST 271
+ EQQ R+R +E +E +Q+ R+ +
Sbjct: 1755 LRPEREEQQLRRQERDRKFREEEQLRQEREEQQLRSQES 1793
Score = 35.0 bits (79), Expect = 0.13
Identities = 28/88 (31%), Positives = 41/88 (46%), Gaps = 9/88 (10%)
Query: 182 KAEKEEENRRLE--------EKRRAEEAQRQLEQERRERELREAARREQRYQEQGGEASP 233
+ +EEE ++ E EKRR +E +RQ +E ++ E RE+ + + E
Sbjct: 1109 QCREEEELQQEEEQLLREEREKRRRQELERQYREEEEVQQEEEQLLREEPEKRRRQELER 1168
Query: 234 QSRTWEQ-QQEVVSRNRNEQESAVHPRE 260
Q R E+ QQE R EQE RE
Sbjct: 1169 QYREEEELQQEEEQLLREEQEKRRQERE 1196
Score = 33.9 bits (76), Expect = 0.29
Identities = 44/187 (23%), Positives = 73/187 (39%), Gaps = 25/187 (13%)
Query: 185 KEEENRRLEEKRRAEEAQRQLEQERRERELREAARREQRYQEQGGEASPQSRTWEQQQEV 244
+E+ R+L + R + QR L +E E+E R RRE+ + Q E Q + E+ Q++
Sbjct: 791 REQRERQLRAEERQQREQRFLPEEE-EKEQRRRQRREREKELQFLEEEEQLQRRERAQQL 849
Query: 245 VSRNRNEQESAVHPR------------EIFKQKERAMSTTSISSPQPGKLRSPFLQKQLT 292
QE R ++ ++++R T +LR Q+ L
Sbjct: 850 QEEEDGLQEDQERRRSQEQRRDQKWRWQLEEERKRRRHTLYAKPALQEQLRKE--QQLLQ 907
Query: 293 QPETHFGREPAAAISRPRADLPAEEPAPSTPPCLVQAEEEAVYEE-----PPEQETFYEQ 347
+ E RE R + E L Q EE+ + EE E+E Y +
Sbjct: 908 EEEEELQREEREKRRRQEQERQYREEEQ-----LQQEEEQLLREEREKRRRQERERQYRK 962
Query: 348 PPLVQQQ 354
+QQ+
Sbjct: 963 DKKLQQK 969
Score = 32.0 bits (71), Expect = 1.1
Identities = 27/93 (29%), Positives = 41/93 (44%), Gaps = 9/93 (9%)
Query: 185 KEEENRRLEEKRRAEEAQRQLEQERRERELREAARREQRYQEQGGEASPQSRTWEQQQEV 244
+ EE +EK R EE + E+E++ R+ RE RE+ + Q E EQ+
Sbjct: 1846 RAEEQFATQEKSRREEQELWQEEEQKRRQERERKLREEHIRRQQKE--------EQRHRQ 1897
Query: 245 VSRNRNEQESAVHPREIFKQKERAMSTTSISSP 277
V ++ QE H R + + S SSP
Sbjct: 1898 VGEIKS-QEGKGHGRLLEPGTHQFASVPVRSSP 1929
Score = 31.6 bits (70), Expect = 1.5
Identities = 17/55 (30%), Positives = 28/55 (50%), Gaps = 1/55 (1%)
Query: 167 AVSEIKRVGKDSFWAKAEKEEENRRLEEKRRAEEAQRQLEQERRERELREAARRE 221
A E R + W + E++ R E K R E +RQ ++E+R R++ E +E
Sbjct: 1852 ATQEKSRREEQELWQEEEQKRRQER-ERKLREEHIRRQQKEEQRHRQVGEIKSQE 1905
Score = 30.4 bits (67), Expect = 3.2
Identities = 27/112 (24%), Positives = 55/112 (49%), Gaps = 12/112 (10%)
Query: 173 RVGKDSFWAKAEKEEENRRLEEKRRAEEAQ-RQLEQERR----ERELREAARREQRYQEQ 227
R +D + + E++ + + K R EE Q R+ E+ER+ E++LR+ R+ R +EQ
Sbjct: 1409 RQDRDRKFREEEQQLSRQERDRKFREEEQQVRRQERERKFLEEEQQLRQERHRKFREEEQ 1468
Query: 228 GGEASPQSRTWEQQQEVVSRNRNEQESAVHPREIFKQKERAMSTTSISSPQP 279
+ + + Q+++ R E+E + +E ++R + S +P
Sbjct: 1469 LLQEREEQQLHRQERD---RKFLEEEQQLRRQE----RDRKFREQELRSQEP 1513
Score = 29.3 bits (64), Expect = 7.2
Identities = 22/85 (25%), Positives = 45/85 (52%), Gaps = 8/85 (9%)
Query: 170 EIKRVGKDSFWAKAEKEEENRRLEEKRRAEEAQRQLEQERRERELREAA-RREQRYQEQG 228
E++R G++ + +E ++R +E+ E +R+ + E +L+E +R++ QE+
Sbjct: 217 ELRRKGREEK-QQQRRERQDRVFQEEEEKEWRKRETVLRKEEEKLQEEEPQRQRELQEE- 274
Query: 229 GEASPQSRTWEQQQEVVSRNRNEQE 253
Q R E+Q+ + R R E+E
Sbjct: 275 ---EEQLRKLERQE--LRRERQEEE 294
>gi|19224660 protein kinase C and casein kinase substrate in neurons
3 [Homo sapiens]
Length = 424
Score = 50.1 bits (118), Expect = 4e-06
Identities = 63/260 (24%), Positives = 106/260 (40%), Gaps = 28/260 (10%)
Query: 183 AEKEEENRRLEEK--RRAEEAQRQLEQERRERELREAARREQRYQEQGGEASPQSRTWEQ 240
A +E+ R+L+E+ R A+EA++ Q E+ L E R RY E +A + E+
Sbjct: 179 AVSQEQLRKLQERVERCAKEAEKTKAQY--EQTLAELHRYTPRYMEDMEQAFETCQAAER 236
Query: 241 QQEVVSRNRN---EQESAVHPREIFKQKERAMSTTSISSPQPGKLR------SPFLQKQL 291
Q+ + ++ Q + E F + R + ++ LR P +
Sbjct: 237 QRLLFFKDMLLTLHQHLDLSSSEKFHELHRDLHQGIEAASDEEDLRWWRSTHGPGMAMNW 296
Query: 292 TQPETHFGREPAAAISRPRADLPAEEPAPSTPPCLVQAEEEAVYEEPPEQETFYEQPPLV 351
Q E + + ISR +E +P +E + P ++ P
Sbjct: 297 PQFE-EWSLDTQRTISR-------KEKGGRSP------DEVTLTSIVPTRDGTAPPPQSP 342
Query: 352 QQQGAGSEHIDHHIQGQGLSGQGLCARALYDYQAADDTEISFDP-ENLITGIEVIDEGWW 410
G G + + + G+ RALYDY + E+SF E L+ E ++GW
Sbjct: 343 GSPGTGQDEEWSDEESPRKAATGVRVRALYDYAGQEADELSFRAGEELLKMSEEDEQGWC 402
Query: 411 RGYGPDGHFGMFPANYVELI 430
+G G G++PANYVE +
Sbjct: 403 QGQLQSGRIGLYPANYVECV 422
>gi|56549694 enabled homolog isoform a [Homo sapiens]
Length = 591
Score = 49.7 bits (117), Expect = 5e-06
Identities = 46/170 (27%), Positives = 74/170 (43%), Gaps = 14/170 (8%)
Query: 182 KAEKEE-ENRRLEEKRRAEEA--QRQLEQERRERELREAARREQRYQEQGG-------EA 231
+ E+E E RLE +R E Q QLE+ER+ERE +E R++R + Q +
Sbjct: 165 RMERERLERERLERERLERERLEQEQLERERQERERQERLERQERLERQERLERQERLDR 224
Query: 232 SPQSRTWEQQQEVVSRNRNEQE--SAVHPREIFKQKERAMSTTSISSPQPGKLRSPFLQK 289
Q R ++ E + R R E+E + ++ ++ER +S+ + + L S
Sbjct: 225 ERQERQERERLERLERERQERERQEQLEREQLEWERERRISSAAAPASVETPLNSVLGDS 284
Query: 290 QLTQPETHFGREPAAAISRPRADLPAEEPAPSTPPCLVQAEEEAVYEEPP 339
++P +PA S+ L P P PP L +A PP
Sbjct: 285 SASEPGLQAASQPAETPSQQGIVLGPLAPPP--PPPLPPGPAQASVALPP 332
Score = 42.7 bits (99), Expect = 6e-04
Identities = 28/88 (31%), Positives = 52/88 (59%), Gaps = 3/88 (3%)
Query: 181 AKAEKEEENRRLEEKRRAEEAQRQ-LEQERRERELREAARREQRYQEQGGEASPQSRTWE 239
++ E E + R+L+E++R +E +R+ LE+ER ERE E R E+ E+ E Q +
Sbjct: 136 SQEELEIQRRQLQEQQRQKELERERLERERMERERLERERLERERLER--ERLEQEQLER 193
Query: 240 QQQEVVSRNRNEQESAVHPREIFKQKER 267
++QE + R E++ + +E +++ER
Sbjct: 194 ERQERERQERLERQERLERQERLERQER 221
Score = 40.0 bits (92), Expect = 0.004
Identities = 29/85 (34%), Positives = 44/85 (51%), Gaps = 4/85 (4%)
Query: 184 EKEEENRRLEEKRRAEEAQRQLEQERRERELREAARREQRYQEQGGEASPQSRTWEQQQE 243
+KE E RLE +R E +LE+ER ERE E R EQ E+ + + E+Q+
Sbjct: 153 QKELERERLERERMERE---RLERERLERERLERERLEQEQLERERQERERQERLERQER 209
Query: 244 VVSRNRNE-QESAVHPREIFKQKER 267
+ + R E QE R+ +++ER
Sbjct: 210 LERQERLERQERLDRERQERQERER 234
>gi|39930375 enabled homolog isoform b [Homo sapiens]
Length = 570
Score = 49.7 bits (117), Expect = 5e-06
Identities = 46/170 (27%), Positives = 74/170 (43%), Gaps = 14/170 (8%)
Query: 182 KAEKEE-ENRRLEEKRRAEEA--QRQLEQERRERELREAARREQRYQEQGG-------EA 231
+ E+E E RLE +R E Q QLE+ER+ERE +E R++R + Q +
Sbjct: 165 RMERERLERERLERERLERERLEQEQLERERQERERQERLERQERLERQERLERQERLDR 224
Query: 232 SPQSRTWEQQQEVVSRNRNEQE--SAVHPREIFKQKERAMSTTSISSPQPGKLRSPFLQK 289
Q R ++ E + R R E+E + ++ ++ER +S+ + + L S
Sbjct: 225 ERQERQERERLERLERERQERERQEQLEREQLEWERERRISSAAAPASVETPLNSVLGDS 284
Query: 290 QLTQPETHFGREPAAAISRPRADLPAEEPAPSTPPCLVQAEEEAVYEEPP 339
++P +PA S+ L P P PP L +A PP
Sbjct: 285 SASEPGLQAASQPAETPSQQGIVLGPLAPPP--PPPLPPGPAQASVALPP 332
Score = 42.7 bits (99), Expect = 6e-04
Identities = 28/88 (31%), Positives = 52/88 (59%), Gaps = 3/88 (3%)
Query: 181 AKAEKEEENRRLEEKRRAEEAQRQ-LEQERRERELREAARREQRYQEQGGEASPQSRTWE 239
++ E E + R+L+E++R +E +R+ LE+ER ERE E R E+ E+ E Q +
Sbjct: 136 SQEELEIQRRQLQEQQRQKELERERLERERMERERLERERLERERLER--ERLEQEQLER 193
Query: 240 QQQEVVSRNRNEQESAVHPREIFKQKER 267
++QE + R E++ + +E +++ER
Sbjct: 194 ERQERERQERLERQERLERQERLERQER 221
Score = 40.0 bits (92), Expect = 0.004
Identities = 29/85 (34%), Positives = 44/85 (51%), Gaps = 4/85 (4%)
Query: 184 EKEEENRRLEEKRRAEEAQRQLEQERRERELREAARREQRYQEQGGEASPQSRTWEQQQE 243
+KE E RLE +R E +LE+ER ERE E R EQ E+ + + E+Q+
Sbjct: 153 QKELERERLERERMERE---RLERERLERERLERERLEQEQLERERQERERQERLERQER 209
Query: 244 VVSRNRNE-QESAVHPREIFKQKER 267
+ + R E QE R+ +++ER
Sbjct: 210 LERQERLERQERLDRERQERQERER 234
Database: hs.faa
Posted date: Aug 4, 2009 4:42 PM
Number of letters in database: 18,247,518
Number of sequences in database: 37,866
Lambda K H
0.311 0.129 0.376
Gapped
Lambda K H
0.267 0.0410 0.140
Matrix: BLOSUM62
Gap Penalties: Existence: 11, Extension: 1
Number of Hits to DB: 19,207,975
Number of Sequences: 37866
Number of extensions: 1047385
Number of successful extensions: 16921
Number of sequences better than 10.0: 30
Number of HSP's better than 10.0 without gapping: 497
Number of HSP's successfully gapped in prelim test: 791
Number of HSP's that attempted gapping in prelim test: 6364
Number of HSP's gapped (non-prelim): 5378
length of query: 431
length of database: 18,247,518
effective HSP length: 105
effective length of query: 326
effective length of database: 14,271,588
effective search space: 4652537688
effective search space used: 4652537688
T: 11
A: 40
X1: 16 ( 7.2 bits)
X2: 38 (14.6 bits)
X3: 64 (24.7 bits)
S1: 42 (21.8 bits)
S2: 63 (28.9 bits)
Search results were obtained with NCBI BLAST and RefSeq entries.
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Guide to the Human Genome
Copyright © 2010 by Stewart Scherer. All rights reserved.