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Search of human proteins with 21361517
BLASTP 2.2.11 [Jun-05-2005]
Reference: Altschul, Stephen F., Thomas L. Madden, Alejandro A. Schaffer,
Jinghui Zhang, Zheng Zhang, Webb Miller, and David J. Lipman (1997),
"Gapped BLAST and PSI-BLAST: a new generation of protein database search
programs", Nucleic Acids Res. 25:3389-3402.
Query= gi|21361517 UBX domain protein 1 [Homo sapiens]
(312 letters)
Database: hs.faa
37,866 sequences; 18,247,518 total letters
Searching..................................................done
Score E
Sequences producing significant alignments: (bits) Value
gi|21361517 UBX domain protein 1 [Homo sapiens] 616 e-177
gi|24307965 UBX domain containing 2 [Homo sapiens] 99 6e-21
gi|55770884 ubiquitin associated domain containing 1 [Homo sapiens] 68 1e-11
gi|24497612 ubiquitin associated and SH3 domain containing, B [H... 65 1e-10
gi|4505101 microtubule-associated protein 7 [Homo sapiens] 64 1e-10
gi|148806928 hypothetical protein LOC57482 [Homo sapiens] 62 7e-10
gi|239754909 PREDICTED: hypothetical protein [Homo sapiens] 61 1e-09
gi|148727247 ubiquitin specific peptidase 5 isoform 2 [Homo sapi... 60 3e-09
gi|148727331 ubiquitin specific peptidase 5 isoform 1 [Homo sapi... 60 3e-09
gi|22035606 mitogen-activated protein kinase kinase kinase kinas... 59 4e-09
gi|22035602 mitogen-activated protein kinase kinase kinase kinas... 59 4e-09
gi|102467235 inner centromere protein antigens 135/155kDa isofor... 59 7e-09
gi|102467242 inner centromere protein antigens 135/155kDa isofor... 59 7e-09
gi|56549694 enabled homolog isoform a [Homo sapiens] 58 9e-09
gi|39930375 enabled homolog isoform b [Homo sapiens] 58 9e-09
gi|156766047 GRB10 interacting GYF protein 2 isoform c [Homo sap... 57 2e-08
gi|156766045 GRB10 interacting GYF protein 2 isoform a [Homo sap... 57 2e-08
gi|156766043 GRB10 interacting GYF protein 2 isoform b [Homo sap... 57 2e-08
gi|42476299 GRB10 interacting GYF protein 2 isoform b [Homo sapi... 57 2e-08
gi|22035604 mitogen-activated protein kinase kinase kinase kinas... 57 2e-08
gi|22758136 MAP7 domain containing 2 [Homo sapiens] 57 2e-08
gi|148746195 trichohyalin [Homo sapiens] 56 4e-08
gi|44680105 caldesmon 1 isoform 1 [Homo sapiens] 56 5e-08
gi|155030232 proline, glutamic acid and leucine rich protein 1 [... 55 8e-08
gi|15149465 caldesmon 1 isoform 5 [Homo sapiens] 55 8e-08
gi|15149463 caldesmon 1 isoform 4 [Homo sapiens] 55 8e-08
gi|15149467 caldesmon 1 isoform 3 [Homo sapiens] 55 8e-08
gi|4826657 caldesmon 1 isoform 2 [Homo sapiens] 55 8e-08
gi|78042577 MAP7 domain containing 1 [Homo sapiens] 55 1e-07
gi|239747134 PREDICTED: hypothetical protein XP_002343921 [Homo ... 54 1e-07
>gi|21361517 UBX domain protein 1 [Homo sapiens]
Length = 312
Score = 616 bits (1589), Expect = e-177
Identities = 312/312 (100%), Positives = 312/312 (100%)
Query: 1 MAELTALESLIEMGFPRGRAEKALALTGNQGIEAAMDWLMEHEDDPDVDEPLETPLGHIL 60
MAELTALESLIEMGFPRGRAEKALALTGNQGIEAAMDWLMEHEDDPDVDEPLETPLGHIL
Sbjct: 1 MAELTALESLIEMGFPRGRAEKALALTGNQGIEAAMDWLMEHEDDPDVDEPLETPLGHIL 60
Query: 61 GREPTSSEQGGLEGSGSAAGEGKPALSEEERQEQTKRMLELVAQKQREREEREEREALER 120
GREPTSSEQGGLEGSGSAAGEGKPALSEEERQEQTKRMLELVAQKQREREEREEREALER
Sbjct: 61 GREPTSSEQGGLEGSGSAAGEGKPALSEEERQEQTKRMLELVAQKQREREEREEREALER 120
Query: 121 ERQRRRQGQELSAARQRLQEDEMRRAAEERRREKAEELAARQRVREKIERDKAERAKKYG 180
ERQRRRQGQELSAARQRLQEDEMRRAAEERRREKAEELAARQRVREKIERDKAERAKKYG
Sbjct: 121 ERQRRRQGQELSAARQRLQEDEMRRAAEERRREKAEELAARQRVREKIERDKAERAKKYG 180
Query: 181 GSVGSQPPPVAPEPGPVPSSPSQEPPTKREYDQCRIQVRLPDGTSLTQTFRAREQLAAVR 240
GSVGSQPPPVAPEPGPVPSSPSQEPPTKREYDQCRIQVRLPDGTSLTQTFRAREQLAAVR
Sbjct: 181 GSVGSQPPPVAPEPGPVPSSPSQEPPTKREYDQCRIQVRLPDGTSLTQTFRAREQLAAVR 240
Query: 241 LYVELHRGEELGGGQDPVQLLSGFPRRAFSEADMERPLQELGMAARLETRTRNWGSREAC 300
LYVELHRGEELGGGQDPVQLLSGFPRRAFSEADMERPLQELGMAARLETRTRNWGSREAC
Sbjct: 241 LYVELHRGEELGGGQDPVQLLSGFPRRAFSEADMERPLQELGMAARLETRTRNWGSREAC 300
Query: 301 LGKGGMQREGAL 312
LGKGGMQREGAL
Sbjct: 301 LGKGGMQREGAL 312
>gi|24307965 UBX domain containing 2 [Homo sapiens]
Length = 508
Score = 98.6 bits (244), Expect = 6e-21
Identities = 67/236 (28%), Positives = 119/236 (50%), Gaps = 23/236 (9%)
Query: 64 PTSSEQG----GLEGSGSAAGEGKPALSEEERQEQ-----TKRMLELVAQKQREREEREE 114
PTS + G E +G A +P+ ++R + +R+ + + +++ E+ + EE
Sbjct: 159 PTSDTKSDTATGGESAGHATSSQEPSGCSDQRPAEDLNIRVERLTKKLEERREEKRKEEE 218
Query: 115 REALERERQRRRQGQELSAARQRLQEDEMRRAAEERRREKAEELAARQRVREKIERDKAE 174
+ +++E +RR+ G+E+ +++ +E+ +R EER REKAE+ AAR+R++++I D+AE
Sbjct: 219 QREIKKEIERRKTGKEMLDYKRKQEEELTKRMLEERNREKAEDRAARERIKQQIALDRAE 278
Query: 175 RAKKYGGSVGSQPPPVAPEPGPVPSSPSQEPPTKRE------YDQCRIQVRLPDGTSLTQ 228
RA ++ V + E KRE RIQ RLPDG+S T
Sbjct: 279 RAARF----AKTKEEVEAAKAAALLAKQAEMEVKRESYARERSTVARIQFRLPDGSSFTN 334
Query: 229 TFRAREQLAAVRLYVELHRGEELGGGQDPVQLLSGFPRRAFSEADMERPLQELGMA 284
F + L R + + +G L + FPRR F++ D ++ L +L +A
Sbjct: 335 QFPSDAPLEEARQFA----AQTVGNTYGNFSLATMFPRREFTKEDYKKKLLDLELA 386
>gi|55770884 ubiquitin associated domain containing 1 [Homo sapiens]
Length = 405
Score = 67.8 bits (164), Expect = 1e-11
Identities = 44/113 (38%), Positives = 59/113 (52%), Gaps = 14/113 (12%)
Query: 6 ALESLIEMGFPRGRAEKALALTGNQGIEAAMDWLMEHEDDPDVDEPLETPLGHILGREPT 65
AL L EMGFP RA KAL L + + AM+WL+EH +DP +D PL G+ P
Sbjct: 196 ALRQLTEMGFPENRATKALQLN-HMSVPQAMEWLIEHAEDPTIDTPLP-------GQAPP 247
Query: 66 SSEQGGLEGSGSAAGEGKPALSEEERQEQTKRMLELVAQKQREREEREEREAL 118
+E G + S A G A EE R E T E+ + +R+RE R + A+
Sbjct: 248 EAE--GATAAASEAAAGASATDEEARDELT----EIFKKIRRKREFRADARAV 294
Score = 28.5 bits (62), Expect = 8.0
Identities = 21/59 (35%), Positives = 28/59 (47%), Gaps = 9/59 (15%)
Query: 2 AELTALESLIEMGFPRGRAEKALALTGNQGIEAAMDWLM--------EHEDDPDVDEPL 52
A+ A+ SL+EMGF AL + NQ AA +WL+ E + D D PL
Sbjct: 289 ADARAVISLMEMGFDEKEVIDALRVNNNQQ-NAACEWLLGDRKPSPEELDKGIDPDSPL 346
>gi|24497612 ubiquitin associated and SH3 domain containing, B
[Homo sapiens]
Length = 649
Score = 64.7 bits (156), Expect = 1e-10
Identities = 31/61 (50%), Positives = 42/61 (68%), Gaps = 2/61 (3%)
Query: 5 TALESLIEMGFPRGRAEKALALTGNQGIEAAMDWLMEHEDDPDVDEPLETPLGHILGREP 64
+AL+ L+ MGFPR RA+KALA TG + ++AA DWL H DP +D+PL P ++L P
Sbjct: 39 SALDVLLSMGFPRARAQKALASTGGRSVQAACDWLFSHVGDPFLDDPL--PREYVLYLRP 96
Query: 65 T 65
T
Sbjct: 97 T 97
>gi|4505101 microtubule-associated protein 7 [Homo sapiens]
Length = 749
Score = 64.3 bits (155), Expect = 1e-10
Identities = 44/136 (32%), Positives = 73/136 (53%), Gaps = 6/136 (4%)
Query: 64 PTSSEQGGLEGSGSAAGEGKPALSEEERQEQTKRMLEL--VAQKQREREEREEREALERE 121
PT + + +A+ K + + +E T+ + E +A++QRE+EERE RE E E
Sbjct: 449 PTPAMVSAPSSTVNASASVKTSAGTTDPEEATRLLAEKRRLAREQREKEERERREQEELE 508
Query: 122 RQRRRQ-GQELSAARQRLQEDEMRRAAEERRREKAEEL---AARQRVREKIERDKAERAK 177
RQ+R + Q ++ R +E+E RR E+ REK E+L A + +RE+ E ++A+R K
Sbjct: 509 RQKREELAQRVAEERTTRREEESRRLEAEQAREKEEQLQRQAEERALREREEAERAQRQK 568
Query: 178 KYGGSVGSQPPPVAPE 193
+ V + V E
Sbjct: 569 EEEARVREEAERVRQE 584
Score = 45.4 bits (106), Expect = 6e-05
Identities = 33/117 (28%), Positives = 60/117 (51%), Gaps = 8/117 (6%)
Query: 60 LGREPTSSEQGGLEGSGSAAGEGKPALSEEERQEQTKRMLE----LVAQKQREREEREER 115
L RE E+ + + L++ +E+T R E L A++ RE+EE+ +R
Sbjct: 489 LAREQREKEERERREQEELERQKREELAQRVAEERTTRREEESRRLEAEQAREKEEQLQR 548
Query: 116 EALERERQRRRQGQELSAARQRLQEDEMRRAAEERRREKAEELAARQRVREKIERDK 172
+A ER + R + + A RQ+ +E +R AE R+E+ + ++ +E++ER K
Sbjct: 549 QAEERALREREEAER--AQRQKEEEARVREEAERVRQEREKHF--QREEQERLERKK 601
Score = 44.7 bits (104), Expect = 1e-04
Identities = 44/159 (27%), Positives = 76/159 (47%), Gaps = 26/159 (16%)
Query: 62 REPTSSEQGGLEGSGSAAGEGKPALSEEERQEQTKR-----MLELVAQKQREREEREERE 116
R T+ + ++ +A+ A+S + + +L + +++ RE REERE
Sbjct: 19 RSETAPDSYKVQDKKNASSRPASAISGQNNNHSGNKPDPPPVLRVDDRQRLARERREERE 78
Query: 117 A---------LERERQRRRQGQE-LSAARQRLQE----DEMRRAA-EERRREKAEELAAR 161
LERE + R+ ++ L ++RL+E +E RRAA EE+RR++ EE R
Sbjct: 79 KQLAAREIVWLEREERARQHYEKHLEERKKRLEEQRQKEERRRAAVEEKRRQRLEEDKER 138
Query: 162 QR--VREKIERDKAERAK----KYGGSVGSQPPPVAPEP 194
VR +ER + + K +GGS+ P + +P
Sbjct: 139 HEAVVRRTMERSQKPKQKHNRWSWGGSLHGSPSIHSADP 177
Score = 44.7 bits (104), Expect = 1e-04
Identities = 28/95 (29%), Positives = 49/95 (51%), Gaps = 5/95 (5%)
Query: 88 EEERQEQTKRMLELVAQKQREREEREER----EALERERQRRRQGQELSAARQRLQEDEM 143
E ERQ++ + + ++ REE R +A E+E Q +RQ +E A R+R + +
Sbjct: 506 ELERQKREELAQRVAEERTTRREEESRRLEAEQAREKEEQLQRQAEE-RALREREEAERA 564
Query: 144 RRAAEERRREKAEELAARQRVREKIERDKAERAKK 178
+R EE R + E RQ + +R++ ER ++
Sbjct: 565 QRQKEEEARVREEAERVRQEREKHFQREEQERLER 599
Score = 40.4 bits (93), Expect = 0.002
Identities = 28/110 (25%), Positives = 46/110 (41%), Gaps = 4/110 (3%)
Query: 90 ERQEQTKRMLELVAQKQREREEREEREALERERQRRRQGQELSAARQRLQEDEMRRAAEE 149
E++EQ +R E A ++RE ER +R+ E R R + + Q +E R +
Sbjct: 541 EKEEQLQRQAEERALREREEAERAQRQKEEEARVREEAERVRQEREKHFQREEQERLERK 600
Query: 150 RRREKAEELAARQRVREKIERDKAE----RAKKYGGSVGSQPPPVAPEPG 195
+R E+ + R +K D+ + GG+ S P PG
Sbjct: 601 KRLEEIMKRTRRTEATDKKTSDQRNGDIAKGALTGGTEVSALPCTTNAPG 650
Score = 32.7 bits (73), Expect = 0.42
Identities = 29/116 (25%), Positives = 47/116 (40%), Gaps = 19/116 (16%)
Query: 71 GLEGSGSAAGEGKPALSEEERQEQTKRMLELVAQKQREREEREEREALERERQRRRQGQE 130
G G G G+G A+ E + + K ++++ R A Q
Sbjct: 5 GAGGDGHRGGDG--AVRSETAPD---------SYKVQDKKNASSRPASAISGQNNNHSGN 53
Query: 131 LSAARQRLQEDEMRRAAEERRREKAEELAAR--------QRVREKIERDKAERAKK 178
L+ D+ +R A ERR E+ ++LAAR +R R+ E+ ER K+
Sbjct: 54 KPDPPPVLRVDDRQRLARERREEREKQLAAREIVWLEREERARQHYEKHLEERKKR 109
Score = 30.8 bits (68), Expect = 1.6
Identities = 23/89 (25%), Positives = 45/89 (50%), Gaps = 2/89 (2%)
Query: 68 EQGGLEGSGSAAGEGKPALSEEERQEQTKRMLELVAQKQREREEREEREALERERQRRRQ 127
EQ + A E + A + ++E+ R+ E + ++ERE+ +RE E+ER R++
Sbjct: 544 EQLQRQAEERALREREEAERAQRQKEEEARVREEAERVRQEREKHFQRE--EQERLERKK 601
Query: 128 GQELSAARQRLQEDEMRRAAEERRREKAE 156
E R R E ++ +++R + A+
Sbjct: 602 RLEEIMKRTRRTEATDKKTSDQRNGDIAK 630
>gi|148806928 hypothetical protein LOC57482 [Homo sapiens]
Length = 1233
Score = 62.0 bits (149), Expect = 7e-10
Identities = 43/101 (42%), Positives = 59/101 (58%), Gaps = 10/101 (9%)
Query: 80 GEGKPALSEEER--QEQTKRMLELVAQKQREREEREEREALERERQRRR-QGQELSAARQ 136
GEG+ E ER +E+ +R LE + ER EREERE LE E +RRR Q Q + R+
Sbjct: 274 GEGQEPPLEAERAPREEQQRSLEAPGWEDAERREREERERLEAEEERRRLQAQAQAEERR 333
Query: 137 RLQEDEMRRAAEERRREKAEELAARQRVREKIERDKAERAK 177
RL+ED EERRR++ EE R E+++R + E A+
Sbjct: 334 RLEED---ARLEERRRQEEEE----GRCAEELKRQEEEEAE 367
Score = 45.1 bits (105), Expect = 8e-05
Identities = 39/142 (27%), Positives = 59/142 (41%), Gaps = 8/142 (5%)
Query: 39 LMEHEDDPDVDEPLETPLGHILGREPTSSEQGGLEGSGSAAGEGKPALSEEERQEQTKRM 98
L+E E + + PLE R P +Q LE G E + E ER E +
Sbjct: 269 LLEEEGEGQ-EPPLEAE------RAPREEQQRSLEAPGWEDAERRER-EERERLEAEEER 320
Query: 99 LELVAQKQREREEREEREALERERQRRRQGQELSAARQRLQEDEMRRAAEERRREKAEEL 158
L AQ Q E R E +A ER+R+ + + A + QE+E EE +++AE
Sbjct: 321 RRLQAQAQAEERRRLEEDARLEERRRQEEEEGRCAEELKRQEEEEAEGWEELEQQEAEVQ 380
Query: 159 AARQRVREKIERDKAERAKKYG 180
+ + E E + + G
Sbjct: 381 GPPEALEETGEGRRGAEEEDLG 402
Score = 43.5 bits (101), Expect = 2e-04
Identities = 48/164 (29%), Positives = 69/164 (42%), Gaps = 48/164 (29%)
Query: 60 LGREPTSSEQGGLEG-----SGSAAGEGKPAL---------SEEERQEQTKRMLELVAQK 105
L ++P EQGGLE GE KP SEEER+ Q EL A+
Sbjct: 177 LAQDP-QHEQGGLESRPCLDQNGHPGEDKPTWHEEEPNPLDSEEERRRQEDYWRELEAKC 235
Query: 106 QREREEREEREALERER----------QRRRQ--------GQELSAARQRLQ-------- 139
+R++ E E+ LE +R + RRQ GQE +R
Sbjct: 236 KRQKAEAAEKRRLEEQRLQALERRLWEENRRQELLEEEGEGQEPPLEAERAPREEQQRSL 295
Query: 140 -----EDEMRRAAEERRREKAEELAARQRVREKIERDKAERAKK 178
ED RR EER R +AEE R+R++ + + ++ R ++
Sbjct: 296 EAPGWEDAERREREERERLEAEE--ERRRLQAQAQAEERRRLEE 337
Score = 36.2 bits (82), Expect = 0.038
Identities = 41/141 (29%), Positives = 63/141 (44%), Gaps = 14/141 (9%)
Query: 61 GREPTSSEQGGLEGSGSA---AGEGKPALSEE---ERQEQTKRMLE----LVAQKQRERE 110
G E ++ ++G A GEG+ EE E +E+ + LE +++ + E
Sbjct: 368 GWEELEQQEAEVQGPPEALEETGEGRRGAEEEDLGEEEEEGQAHLEDWRGQLSELLNDFE 427
Query: 111 ER-EEREALERERQRRRQGQELSAARQRLQEDEMRRAAEERRREKAEELAARQRVREKIE 169
ER E++E L+ E QR +E ++ E E RR E++ R + A R EK E
Sbjct: 428 ERLEDQERLKPEGQREHS-EEPGICEEQNPEAERRR--EQQGRSGDFQGADRPGPEEKRE 484
Query: 170 RDKAERAKKYGGSVGSQPPPV 190
E K G V + PPV
Sbjct: 485 EGDTEPLLKQEGPVEAAQPPV 505
>gi|239754909 PREDICTED: hypothetical protein [Homo sapiens]
Length = 245
Score = 61.2 bits (147), Expect = 1e-09
Identities = 35/117 (29%), Positives = 65/117 (55%), Gaps = 1/117 (0%)
Query: 61 GREPTSSEQGGLEGSGSAAGEGKPALSEEERQEQTKRMLELVAQKQREREEREEREALER 120
G+E E+ E + + E ER+E+ KR + V +K+ ER+E+E +E +R
Sbjct: 130 GKERERKEERKREERKERERKKEEREKERERKERKKRERKQVGEKEEERKEKERKERKKR 189
Query: 121 ERQRRRQGQELSAARQRLQEDEMRRAAEERRREKAEELAARQRVREKIERDKAERAK 177
ER R+ + +E +R ++ E R+ EER++E+ ++ R +E+ +R++ ER K
Sbjct: 190 ERNRKERKKERERKERRERKKE-RKKKEERKKERQKDRQTNWREKERGKRERKERKK 245
Score = 57.8 bits (138), Expect = 1e-08
Identities = 41/119 (34%), Positives = 64/119 (53%), Gaps = 8/119 (6%)
Query: 61 GREPTSSEQGGLEGSGSAAGEGKPALSEEERQEQTKRMLELVAQKQREREERE-EREALE 119
G E ++ + G + EGK E ER+E+ KR E +++R++EERE ERE E
Sbjct: 109 GEEKEKRKKKEKKERGRTSKEGK----ERERKEERKR--EERKERERKKEEREKERERKE 162
Query: 120 RERQRRRQGQELSAARQRLQEDEMRRAAEERRREKAEELAARQRVREKIERDKAERAKK 178
R+++ R+Q E R+ + E R+ E R+E+ +E ++R K ER K E KK
Sbjct: 163 RKKRERKQVGEKEEERKEKERKE-RKKRERNRKERKKERERKERRERKKERKKKEERKK 220
Score = 54.7 bits (130), Expect = 1e-07
Identities = 41/126 (32%), Positives = 66/126 (52%), Gaps = 21/126 (16%)
Query: 81 EGKPALSEE---ERQEQTKRMLELVAQKQRER---EEREEREALERERQRRRQGQELSAA 134
EGK E ER+E+ KR E +++RER E++ ER+ ERER++RR+ +E
Sbjct: 50 EGKKERESERKKERREREKRKREREKERKRERGKKEKKGERKKEERERKKRRREKENKEG 109
Query: 135 RQR--------------LQEDEMRRAAEERRREKAEELAARQRVREKIERDKAERAKKYG 180
++ +E + R EER+RE+ +E ++ REK ER++ ER K+
Sbjct: 110 EEKEKRKKKEKKERGRTSKEGKERERKEERKREERKERERKKEEREK-ERERKERKKRER 168
Query: 181 GSVGSQ 186
VG +
Sbjct: 169 KQVGEK 174
Score = 50.8 bits (120), Expect = 2e-06
Identities = 29/99 (29%), Positives = 59/99 (59%), Gaps = 5/99 (5%)
Query: 81 EGKPALSEEERQEQTKRMLELVAQKQREREEREEREALER-ERQRRRQGQELSAARQRLQ 139
E K +E+R+++ K+ +++ +ERE +EER+ ER ER+R+++ +E R+ +
Sbjct: 105 ENKEGEEKEKRKKKEKKERGRTSKEGKERERKEERKREERKERERKKEEREKERERKERK 164
Query: 140 EDEMRRAAEERRREKAEELAARQRVREKIERDKAERAKK 178
+ E ++ E+ K +E ++ R+K ER++ ER K+
Sbjct: 165 KRERKQVGEKEEERKEKE----RKERKKRERNRKERKKE 199
Score = 49.3 bits (116), Expect = 4e-06
Identities = 32/116 (27%), Positives = 61/116 (52%), Gaps = 6/116 (5%)
Query: 68 EQGGLEGSGSAAGEGKPALSEEERQEQTKRMLELVAQKQREREE--REEREALERERQRR 125
E+G E G E + + R+++ K E +K++E++E R +E ERER+
Sbjct: 80 ERGKKEKKGERKKEERER-KKRRREKENKEGEEKEKRKKKEKKERGRTSKEGKERERKEE 138
Query: 126 RQGQELSAARQRLQEDEMRRAAEERRREKAEELAARQRVR---EKIERDKAERAKK 178
R+ +E ++ +E E R +ER++ + +++ ++ R E+ ER K ER +K
Sbjct: 139 RKREERKERERKKEEREKERERKERKKRERKQVGEKEEERKEKERKERKKRERNRK 194
Score = 48.5 bits (114), Expect = 7e-06
Identities = 35/125 (28%), Positives = 64/125 (51%), Gaps = 9/125 (7%)
Query: 62 REPTSSEQGGLEGSGSAAGEGKPALSEEERQEQTKRMLELVAQKQR-EREERE------- 113
R+ ++ G E K EER+E+ ++ E +++R ER++RE
Sbjct: 115 RKKKEKKERGRTSKEGKERERKEERKREERKERERKKEEREKERERKERKKRERKQVGEK 174
Query: 114 EREALERERQRRRQGQELSAARQRLQEDEMRRAAEERRREKAEELAARQRVREKIERDKA 173
E E E+ER+ R++ + R++ +E + RR ++ R++K E RQ+ R+ R+K
Sbjct: 175 EEERKEKERKERKKRERNRKERKKERERKERRERKKERKKKEERKKERQKDRQTNWREK- 233
Query: 174 ERAKK 178
ER K+
Sbjct: 234 ERGKR 238
Score = 48.1 bits (113), Expect = 1e-05
Identities = 30/97 (30%), Positives = 57/97 (58%), Gaps = 6/97 (6%)
Query: 86 LSEEERQEQTKR--MLELVAQKQREREEREEREALERERQRRRQGQELSAARQRLQEDEM 143
+ E ER+ +T++ E +++++ER ERE+R+ ERE++R+R+ + +R +E+
Sbjct: 38 IREREREIETRKEGKKERESERKKERREREKRKR-EREKERKRERGKKEKKGERKKEERE 96
Query: 144 RRAAEERRREKAEELAARQRVREKIERDKAERAKKYG 180
R+ +RRREK + + R+K E+ + R K G
Sbjct: 97 RK---KRRREKENKEGEEKEKRKKKEKKERGRTSKEG 130
Score = 46.6 bits (109), Expect = 3e-05
Identities = 30/97 (30%), Positives = 52/97 (53%), Gaps = 7/97 (7%)
Query: 83 KPALSEEERQEQTKRMLELVAQKQREREEREEREALERERQRRRQGQELSAARQR-LQED 141
KP + E +R E+ +K+ ++E ER+ RER++R++ +E R+R +E
Sbjct: 27 KPCTQPGWQSEIREREREIETRKEGKKERESERKKERREREKRKREREKERKRERGKKEK 86
Query: 142 EMRRAAEERRREKAEELAARQRVREKIERDKAERAKK 178
+ R EER R+K R+R +E E ++ E+ KK
Sbjct: 87 KGERKKEERERKK------RRREKENKEGEEKEKRKK 117
Score = 42.4 bits (98), Expect = 5e-04
Identities = 25/91 (27%), Positives = 50/91 (54%), Gaps = 3/91 (3%)
Query: 88 EEERQEQTKRMLELVAQKQREREEREEREALERERQRRRQGQELSAARQRLQEDEMRRAA 147
E E +++ K+ E +K+R E+ +RE E+ER+R R +E R++ + + +R
Sbjct: 44 EIETRKEGKKERESERKKERREREKRKRER-EKERKRERGKKEKKGERKKEERERKKRRR 102
Query: 148 EERRREKAEELAARQRVREKIERDKAERAKK 178
E+ +E E+ +++ +EK ER + + K
Sbjct: 103 EKENKEGEEK--EKRKKKEKKERGRTSKEGK 131
>gi|148727247 ubiquitin specific peptidase 5 isoform 2 [Homo
sapiens]
Length = 835
Score = 59.7 bits (143), Expect = 3e-09
Identities = 27/55 (49%), Positives = 34/55 (61%)
Query: 1 MAELTALESLIEMGFPRGRAEKALALTGNQGIEAAMDWLMEHEDDPDVDEPLETP 55
M + + + L+EMGFP KA+ TGN G EAAM+W+M H DDPD PL P
Sbjct: 631 MLDESVIIQLVEMGFPMDACRKAVYYTGNSGAEAAMNWVMSHMDDPDFANPLILP 685
Score = 40.4 bits (93), Expect = 0.002
Identities = 19/49 (38%), Positives = 29/49 (59%), Gaps = 1/49 (2%)
Query: 9 SLIEMGFPRGRAEKALALTGNQGIEAAMDWLMEHEDDPDVDEPLETPLG 57
+++ MGF R +A KAL T N +E A+DW+ H DD D + ++ G
Sbjct: 707 TIVSMGFSRDQALKALRATNNS-LERAVDWIFSHIDDLDAEAAMDISEG 754
>gi|148727331 ubiquitin specific peptidase 5 isoform 1 [Homo
sapiens]
Length = 858
Score = 59.7 bits (143), Expect = 3e-09
Identities = 27/55 (49%), Positives = 34/55 (61%)
Query: 1 MAELTALESLIEMGFPRGRAEKALALTGNQGIEAAMDWLMEHEDDPDVDEPLETP 55
M + + + L+EMGFP KA+ TGN G EAAM+W+M H DDPD PL P
Sbjct: 654 MLDESVIIQLVEMGFPMDACRKAVYYTGNSGAEAAMNWVMSHMDDPDFANPLILP 708
Score = 40.4 bits (93), Expect = 0.002
Identities = 19/49 (38%), Positives = 29/49 (59%), Gaps = 1/49 (2%)
Query: 9 SLIEMGFPRGRAEKALALTGNQGIEAAMDWLMEHEDDPDVDEPLETPLG 57
+++ MGF R +A KAL T N +E A+DW+ H DD D + ++ G
Sbjct: 730 TIVSMGFSRDQALKALRATNNS-LERAVDWIFSHIDDLDAEAAMDISEG 777
>gi|22035606 mitogen-activated protein kinase kinase kinase kinase 4
isoform 3 [Homo sapiens]
Length = 1212
Score = 59.3 bits (142), Expect = 4e-09
Identities = 36/121 (29%), Positives = 66/121 (54%), Gaps = 6/121 (4%)
Query: 90 ERQEQTKRMLELVAQKQREREEREEREALERERQRRRQGQELSAARQRLQEDEMRRAAEE 149
E+Q++ +R LE +++RE ++ERE RE++ +R+ +EL R+R +E+E RRA EE
Sbjct: 400 EQQKEQRRRLEEQQRREREARRQQEREQRRREQEEKRRLEELE--RRRKEEEERRRAEEE 457
Query: 150 RRREKAEELAARQRVREKIERDKAERAKKYGGSVGSQPPPVAPEPGPVPSSPSQEPPTKR 209
+RR + E+ + +R ++E ++ + Q + P P Q PP ++
Sbjct: 458 KRRVEREQ----EYIRRQLEEEQRHLEVLQQQLLQEQAMLLHDHRRPHPQHSQQPPPPQQ 513
Query: 210 E 210
E
Sbjct: 514 E 514
Score = 45.8 bits (107), Expect = 5e-05
Identities = 31/104 (29%), Positives = 55/104 (52%), Gaps = 14/104 (13%)
Query: 87 SEEERQ----------EQTKRMLELVAQKQ-REREEREEREALERERQRRRQGQELSAAR 135
SE R+ EQ + +L+A++Q R +++E+R LE +++R R+ +
Sbjct: 367 SEALRRQQLLQEQQLREQEEYKRQLLAERQKRIEQQKEQRRRLEEQQRREREARRQQERE 426
Query: 136 QRLQEDEMRRAAEERRREKAEELAARQRVREKIERDKAERAKKY 179
QR +E E +R EE R + EE +R R + E+ + ER ++Y
Sbjct: 427 QRRREQEEKRRLEELERRRKEE---EERRRAEEEKRRVEREQEY 467
Score = 44.7 bits (104), Expect = 1e-04
Identities = 36/103 (34%), Positives = 57/103 (55%), Gaps = 8/103 (7%)
Query: 81 EGKPALSEEERQEQTKRMLEL-VAQKQREREEREEREALERERQRRRQGQ---ELSAARQ 136
EG+P+ E T R L + Q+ +ER E R+ L +E+Q R Q + +L A RQ
Sbjct: 337 EGEPSSIVNVPGESTLRRDFLRLQQENKERSEALRRQQLLQEQQLREQEEYKRQLLAERQ 396
Query: 137 RL--QEDEMRRAAEERRREKAEELAARQRVREKIERDKAERAK 177
+ Q+ E RR EE++R + E A RQ+ RE+ R++ E+ +
Sbjct: 397 KRIEQQKEQRRRLEEQQRRERE--ARRQQEREQRRREQEEKRR 437
Score = 43.5 bits (101), Expect = 2e-04
Identities = 28/95 (29%), Positives = 52/95 (54%), Gaps = 7/95 (7%)
Query: 89 EERQEQTKRMLELVAQKQREREEREEREALERERQRR-----RQGQELSAARQRLQEDEM 143
+ER E +R + + Q+Q+ RE+ E + L ERQ+R Q + L ++R +E
Sbjct: 364 KERSEALRR--QQLLQEQQLREQEEYKRQLLAERQKRIEQQKEQRRRLEEQQRREREARR 421
Query: 144 RRAAEERRREKAEELAARQRVREKIERDKAERAKK 178
++ E+RRRE+ E+ + R + E ++ RA++
Sbjct: 422 QQEREQRRREQEEKRRLEELERRRKEEEERRRAEE 456
Score = 35.8 bits (81), Expect = 0.050
Identities = 21/73 (28%), Positives = 40/73 (54%), Gaps = 9/73 (12%)
Query: 88 EEERQEQTKRMLELVAQKQREREER----EEREALERE-----RQRRRQGQELSAARQRL 138
+ R+++ KR LE + ++++E EER EE+ +ERE RQ + + L +Q+L
Sbjct: 427 QRRREQEEKRRLEELERRRKEEEERRRAEEEKRRVEREQEYIRRQLEEEQRHLEVLQQQL 486
Query: 139 QEDEMRRAAEERR 151
+++ + RR
Sbjct: 487 LQEQAMLLHDHRR 499
>gi|22035602 mitogen-activated protein kinase kinase kinase kinase 4
isoform 1 [Homo sapiens]
Length = 1166
Score = 59.3 bits (142), Expect = 4e-09
Identities = 36/121 (29%), Positives = 66/121 (54%), Gaps = 6/121 (4%)
Query: 90 ERQEQTKRMLELVAQKQREREEREEREALERERQRRRQGQELSAARQRLQEDEMRRAAEE 149
E+Q++ +R LE +++RE ++ERE RE++ +R+ +EL R+R +E+E RRA EE
Sbjct: 400 EQQKEQRRRLEEQQRREREARRQQEREQRRREQEEKRRLEELE--RRRKEEEERRRAEEE 457
Query: 150 RRREKAEELAARQRVREKIERDKAERAKKYGGSVGSQPPPVAPEPGPVPSSPSQEPPTKR 209
+RR + E+ + +R ++E ++ + Q + P P Q PP ++
Sbjct: 458 KRRVEREQ----EYIRRQLEEEQRHLEVLQQQLLQEQAMLLHDHRRPHPQHSQQPPPPQQ 513
Query: 210 E 210
E
Sbjct: 514 E 514
Score = 45.8 bits (107), Expect = 5e-05
Identities = 31/104 (29%), Positives = 55/104 (52%), Gaps = 14/104 (13%)
Query: 87 SEEERQ----------EQTKRMLELVAQKQ-REREEREEREALERERQRRRQGQELSAAR 135
SE R+ EQ + +L+A++Q R +++E+R LE +++R R+ +
Sbjct: 367 SEALRRQQLLQEQQLREQEEYKRQLLAERQKRIEQQKEQRRRLEEQQRREREARRQQERE 426
Query: 136 QRLQEDEMRRAAEERRREKAEELAARQRVREKIERDKAERAKKY 179
QR +E E +R EE R + EE +R R + E+ + ER ++Y
Sbjct: 427 QRRREQEEKRRLEELERRRKEE---EERRRAEEEKRRVEREQEY 467
Score = 44.7 bits (104), Expect = 1e-04
Identities = 36/103 (34%), Positives = 57/103 (55%), Gaps = 8/103 (7%)
Query: 81 EGKPALSEEERQEQTKRMLEL-VAQKQREREEREEREALERERQRRRQGQ---ELSAARQ 136
EG+P+ E T R L + Q+ +ER E R+ L +E+Q R Q + +L A RQ
Sbjct: 337 EGEPSSIVNVPGESTLRRDFLRLQQENKERSEALRRQQLLQEQQLREQEEYKRQLLAERQ 396
Query: 137 RL--QEDEMRRAAEERRREKAEELAARQRVREKIERDKAERAK 177
+ Q+ E RR EE++R + E A RQ+ RE+ R++ E+ +
Sbjct: 397 KRIEQQKEQRRRLEEQQRRERE--ARRQQEREQRRREQEEKRR 437
Score = 43.5 bits (101), Expect = 2e-04
Identities = 28/95 (29%), Positives = 52/95 (54%), Gaps = 7/95 (7%)
Query: 89 EERQEQTKRMLELVAQKQREREEREEREALERERQRR-----RQGQELSAARQRLQEDEM 143
+ER E +R + + Q+Q+ RE+ E + L ERQ+R Q + L ++R +E
Sbjct: 364 KERSEALRR--QQLLQEQQLREQEEYKRQLLAERQKRIEQQKEQRRRLEEQQRREREARR 421
Query: 144 RRAAEERRREKAEELAARQRVREKIERDKAERAKK 178
++ E+RRRE+ E+ + R + E ++ RA++
Sbjct: 422 QQEREQRRREQEEKRRLEELERRRKEEEERRRAEE 456
Score = 40.4 bits (93), Expect = 0.002
Identities = 35/153 (22%), Positives = 69/153 (45%), Gaps = 20/153 (13%)
Query: 88 EEERQEQTKRMLELVAQKQREREER----EEREALERE-----RQRRRQGQELSAARQRL 138
+ R+++ KR LE + ++++E EER EE+ +ERE RQ + + L +Q+L
Sbjct: 427 QRRREQEEKRRLEELERRRKEEEERRRAEEEKRRVEREQEYIRRQLEEEQRHLEVLQQQL 486
Query: 139 QEDEMRRAAEERR--REKAEELAARQRVRE---------KIERDKAERAKKYGGSVGSQP 187
+++ + RR + +++ Q+ R K + A+RA++ S+
Sbjct: 487 LQEQAMLLHDHRRPHPQHSQQPPPPQQERSKPSFHAPEPKAHYEPADRAREVPVRTTSRS 546
Query: 188 PPVAPEPGPVPSSPSQEPPTKREYDQCRIQVRL 220
P ++ P+ S Q + I+ RL
Sbjct: 547 PVLSRRDSPLQGSGQQNSQAGQRNSTSSIEPRL 579
>gi|102467235 inner centromere protein antigens 135/155kDa isoform 1
[Homo sapiens]
Length = 918
Score = 58.5 bits (140), Expect = 7e-09
Identities = 32/97 (32%), Positives = 62/97 (63%), Gaps = 9/97 (9%)
Query: 88 EEERQEQTKRMLELVAQKQREREEREEREALERERQRRRQGQELSAARQ--------RLQ 139
E+ER+EQ +R E Q++RE+E RE+ L E++RRR+ + L A R+ RLQ
Sbjct: 689 EQERREQERREQERREQERREQERREQERQL-AEQERRREQERLQAERELQEREKALRLQ 747
Query: 140 EDEMRRAAEERRREKAEELAARQRVREKIERDKAERA 176
+++++R EE+++++ ++ A ++++E+ E+ E A
Sbjct: 748 KEQLQRELEEKKKKEEQQRLAERQLQEEQEKKAKEAA 784
Score = 54.3 bits (129), Expect = 1e-07
Identities = 34/99 (34%), Positives = 56/99 (56%), Gaps = 8/99 (8%)
Query: 88 EEERQE------QTKRMLELVAQKQRERE--EREEREALERERQRRRQGQELSAARQRLQ 139
+EE QE + KR+ E Q++RE+E E+E RE RE++RR Q ++L+ +R +
Sbjct: 668 KEEEQERLRKAAEAKRLAEQREQERREQERREQERREQERREQERREQERQLAEQERRRE 727
Query: 140 EDEMRRAAEERRREKAEELAARQRVREKIERDKAERAKK 178
++ ++ E + REKA L Q RE E+ K E ++
Sbjct: 728 QERLQAERELQEREKALRLQKEQLQRELEEKKKKEEQQR 766
Score = 52.8 bits (125), Expect = 4e-07
Identities = 33/100 (33%), Positives = 56/100 (56%), Gaps = 14/100 (14%)
Query: 90 ERQEQTKRMLELVAQKQREREER-----------EEREALERERQRRRQGQELSAARQRL 138
+++E+ +R EL+ +K+ E +ER E+RE RE++RR Q + R++
Sbjct: 652 QQEEEERRHQELLQKKKEEEQERLRKAAEAKRLAEQREQERREQERREQERREQERREQE 711
Query: 139 QEDEMRRAAEERRREKAEELAARQRVREKIERDKAERAKK 178
+ ++ R+ AE+ RR + E L A RE ER+KA R +K
Sbjct: 712 RREQERQLAEQERRREQERLQAE---RELQEREKALRLQK 748
Score = 48.9 bits (115), Expect = 6e-06
Identities = 29/100 (29%), Positives = 57/100 (57%), Gaps = 2/100 (2%)
Query: 79 AGEGKPALSEEERQEQTKRMLELVAQKQREREEREEREALERERQRRRQGQELSAARQRL 138
A E + A + +++ K+M E+ A++++E E R R + E +RR Q EL ++
Sbjct: 613 AKEERLAEEKAKKKAAAKKMEEVEARRKQEEEARRLRWLQQEEEERRHQ--ELLQKKKEE 670
Query: 139 QEDEMRRAAEERRREKAEELAARQRVREKIERDKAERAKK 178
+++ +R+AAE +R + E R++ R + ER + ER ++
Sbjct: 671 EQERLRKAAEAKRLAEQREQERREQERREQERREQERREQ 710
Score = 39.7 bits (91), Expect = 0.003
Identities = 21/76 (27%), Positives = 47/76 (61%), Gaps = 1/76 (1%)
Query: 81 EGKPALSEEERQEQTKRMLELVAQKQREREEREEREALERE-RQRRRQGQELSAARQRLQ 139
E + L+E+ER+ + +R+ ++RE+ R ++E L+RE +++++ ++ A ++LQ
Sbjct: 714 EQERQLAEQERRREQERLQAERELQEREKALRLQKEQLQRELEEKKKKEEQQRLAERQLQ 773
Query: 140 EDEMRRAAEERRREKA 155
E++ ++A E KA
Sbjct: 774 EEQEKKAKEAAGASKA 789
Score = 39.3 bits (90), Expect = 0.005
Identities = 28/115 (24%), Positives = 59/115 (51%), Gaps = 15/115 (13%)
Query: 79 AGEGKPALSEEERQEQTKRMLELVAQKQREREER--EER-------EALERERQRRRQGQ 129
A E + EE++++ ++ ++ + ++ +EER EE+ + +E RR+Q +
Sbjct: 584 ARERVEQMKEEKKKQIEQKFAQIDEKTEKAKEERLAEEKAKKKAAAKKMEEVEARRKQEE 643
Query: 130 ELSAARQRLQEDEMRRAAE------ERRREKAEELAARQRVREKIERDKAERAKK 178
E R QE+E RR E E +E+ + A +R+ E+ E+++ E+ ++
Sbjct: 644 EARRLRWLQQEEEERRHQELLQKKKEEEQERLRKAAEAKRLAEQREQERREQERR 698
Score = 33.1 bits (74), Expect = 0.33
Identities = 20/90 (22%), Positives = 48/90 (53%), Gaps = 3/90 (3%)
Query: 81 EGKPALSEEERQEQTKRMLELVAQKQREREEREEREALERERQRRRQGQELSAARQRLQE 140
E K EE + ++ +R+ +++ ++R + +EE++ ++ + + A +RL E
Sbjct: 561 EDKRRRLEEVKLKREERLRKVLQARERVEQMKEEKKKQIEQKFAQIDEKTEKAKEERLAE 620
Query: 141 DEMRRAAEERRREKAEELAARQRVREKIER 170
++ ++ A + K EE+ AR++ E+ R
Sbjct: 621 EKAKKKAAAK---KMEEVEARRKQEEEARR 647
Score = 31.6 bits (70), Expect = 0.95
Identities = 26/103 (25%), Positives = 56/103 (54%), Gaps = 18/103 (17%)
Query: 83 KPALSEEERQE-QTKRMLELVAQKQREREEREEREALERERQRRRQG-QELSAARQRLQE 140
K + E+ERQ + R E Q +R++ E ++R LE + +R + +++ AR+R+++
Sbjct: 531 KCSFVEKERQRLENLRRKEEAEQLRRQKVEEDKRRRLEEVKLKREERLRKVLQARERVEQ 590
Query: 141 --DEMRRAAEER------RREKAEELAARQRVREKIERDKAER 175
+E ++ E++ + EKA+E E++ +KA++
Sbjct: 591 MKEEKKKQIEQKFAQIDEKTEKAKE--------ERLAEEKAKK 625
Score = 29.6 bits (65), Expect = 3.6
Identities = 16/44 (36%), Positives = 27/44 (61%), Gaps = 2/44 (4%)
Query: 135 RQRLQEDEMRRAAEERRREKAEELAARQRVREKIERDKAERAKK 178
RQRL+ + AE+ RR+K EE ++R E+++ + ER +K
Sbjct: 539 RQRLENLRRKEEAEQLRRQKVEE--DKRRRLEEVKLKREERLRK 580
>gi|102467242 inner centromere protein antigens 135/155kDa isoform 2
[Homo sapiens]
Length = 914
Score = 58.5 bits (140), Expect = 7e-09
Identities = 32/97 (32%), Positives = 62/97 (63%), Gaps = 9/97 (9%)
Query: 88 EEERQEQTKRMLELVAQKQREREEREEREALERERQRRRQGQELSAARQ--------RLQ 139
E+ER+EQ +R E Q++RE+E RE+ L E++RRR+ + L A R+ RLQ
Sbjct: 685 EQERREQERREQERREQERREQERREQERQL-AEQERRREQERLQAERELQEREKALRLQ 743
Query: 140 EDEMRRAAEERRREKAEELAARQRVREKIERDKAERA 176
+++++R EE+++++ ++ A ++++E+ E+ E A
Sbjct: 744 KEQLQRELEEKKKKEEQQRLAERQLQEEQEKKAKEAA 780
Score = 54.3 bits (129), Expect = 1e-07
Identities = 34/99 (34%), Positives = 56/99 (56%), Gaps = 8/99 (8%)
Query: 88 EEERQE------QTKRMLELVAQKQRERE--EREEREALERERQRRRQGQELSAARQRLQ 139
+EE QE + KR+ E Q++RE+E E+E RE RE++RR Q ++L+ +R +
Sbjct: 664 KEEEQERLRKAAEAKRLAEQREQERREQERREQERREQERREQERREQERQLAEQERRRE 723
Query: 140 EDEMRRAAEERRREKAEELAARQRVREKIERDKAERAKK 178
++ ++ E + REKA L Q RE E+ K E ++
Sbjct: 724 QERLQAERELQEREKALRLQKEQLQRELEEKKKKEEQQR 762
Score = 52.8 bits (125), Expect = 4e-07
Identities = 33/100 (33%), Positives = 56/100 (56%), Gaps = 14/100 (14%)
Query: 90 ERQEQTKRMLELVAQKQREREER-----------EEREALERERQRRRQGQELSAARQRL 138
+++E+ +R EL+ +K+ E +ER E+RE RE++RR Q + R++
Sbjct: 648 QQEEEERRHQELLQKKKEEEQERLRKAAEAKRLAEQREQERREQERREQERREQERREQE 707
Query: 139 QEDEMRRAAEERRREKAEELAARQRVREKIERDKAERAKK 178
+ ++ R+ AE+ RR + E L A RE ER+KA R +K
Sbjct: 708 RREQERQLAEQERRREQERLQAE---RELQEREKALRLQK 744
Score = 48.9 bits (115), Expect = 6e-06
Identities = 29/100 (29%), Positives = 57/100 (57%), Gaps = 2/100 (2%)
Query: 79 AGEGKPALSEEERQEQTKRMLELVAQKQREREEREEREALERERQRRRQGQELSAARQRL 138
A E + A + +++ K+M E+ A++++E E R R + E +RR Q EL ++
Sbjct: 609 AKEERLAEEKAKKKAAAKKMEEVEARRKQEEEARRLRWLQQEEEERRHQ--ELLQKKKEE 666
Query: 139 QEDEMRRAAEERRREKAEELAARQRVREKIERDKAERAKK 178
+++ +R+AAE +R + E R++ R + ER + ER ++
Sbjct: 667 EQERLRKAAEAKRLAEQREQERREQERREQERREQERREQ 706
Score = 39.7 bits (91), Expect = 0.003
Identities = 21/76 (27%), Positives = 47/76 (61%), Gaps = 1/76 (1%)
Query: 81 EGKPALSEEERQEQTKRMLELVAQKQREREEREEREALERE-RQRRRQGQELSAARQRLQ 139
E + L+E+ER+ + +R+ ++RE+ R ++E L+RE +++++ ++ A ++LQ
Sbjct: 710 EQERQLAEQERRREQERLQAERELQEREKALRLQKEQLQRELEEKKKKEEQQRLAERQLQ 769
Query: 140 EDEMRRAAEERRREKA 155
E++ ++A E KA
Sbjct: 770 EEQEKKAKEAAGASKA 785
Score = 39.3 bits (90), Expect = 0.005
Identities = 28/115 (24%), Positives = 59/115 (51%), Gaps = 15/115 (13%)
Query: 79 AGEGKPALSEEERQEQTKRMLELVAQKQREREER--EER-------EALERERQRRRQGQ 129
A E + EE++++ ++ ++ + ++ +EER EE+ + +E RR+Q +
Sbjct: 580 ARERVEQMKEEKKKQIEQKFAQIDEKTEKAKEERLAEEKAKKKAAAKKMEEVEARRKQEE 639
Query: 130 ELSAARQRLQEDEMRRAAE------ERRREKAEELAARQRVREKIERDKAERAKK 178
E R QE+E RR E E +E+ + A +R+ E+ E+++ E+ ++
Sbjct: 640 EARRLRWLQQEEEERRHQELLQKKKEEEQERLRKAAEAKRLAEQREQERREQERR 694
Score = 36.2 bits (82), Expect = 0.038
Identities = 27/75 (36%), Positives = 41/75 (54%), Gaps = 6/75 (8%)
Query: 105 KQREREEREEREALERERQRRRQGQELSAARQRLQEDEMRRAAEERRREKAEELAARQRV 164
K++ER+ E E Q RRQ E R+RL+E +++R EER R + L AR+RV
Sbjct: 531 KEKERQRLENLRRKEEAEQLRRQKVE-EDKRRRLEEVKLKR--EERLR---KVLQARERV 584
Query: 165 REKIERDKAERAKKY 179
+ E K + +K+
Sbjct: 585 EQMKEEKKKQIEQKF 599
Score = 33.1 bits (74), Expect = 0.33
Identities = 20/90 (22%), Positives = 48/90 (53%), Gaps = 3/90 (3%)
Query: 81 EGKPALSEEERQEQTKRMLELVAQKQREREEREEREALERERQRRRQGQELSAARQRLQE 140
E K EE + ++ +R+ +++ ++R + +EE++ ++ + + A +RL E
Sbjct: 557 EDKRRRLEEVKLKREERLRKVLQARERVEQMKEEKKKQIEQKFAQIDEKTEKAKEERLAE 616
Query: 141 DEMRRAAEERRREKAEELAARQRVREKIER 170
++ ++ A + K EE+ AR++ E+ R
Sbjct: 617 EKAKKKAAAK---KMEEVEARRKQEEEARR 643
Score = 31.2 bits (69), Expect = 1.2
Identities = 25/98 (25%), Positives = 54/98 (55%), Gaps = 18/98 (18%)
Query: 88 EEERQE-QTKRMLELVAQKQREREEREEREALERERQRRRQG-QELSAARQRLQE--DEM 143
E+ERQ + R E Q +R++ E ++R LE + +R + +++ AR+R+++ +E
Sbjct: 532 EKERQRLENLRRKEEAEQLRRQKVEEDKRRRLEEVKLKREERLRKVLQARERVEQMKEEK 591
Query: 144 RRAAEER------RREKAEELAARQRVREKIERDKAER 175
++ E++ + EKA+E E++ +KA++
Sbjct: 592 KKQIEQKFAQIDEKTEKAKE--------ERLAEEKAKK 621
Score = 29.6 bits (65), Expect = 3.6
Identities = 18/87 (20%), Positives = 45/87 (51%), Gaps = 2/87 (2%)
Query: 91 RQEQTKRMLELVAQKQREREERE-EREALERERQRRRQGQELSAARQRLQEDEMRRAAEE 149
R + ++ + + +R+ E + R+ +E +++RR + +L + + + R E+
Sbjct: 527 RMDPKEKERQRLENLRRKEEAEQLRRQKVEEDKRRRLEEVKLKREERLRKVLQARERVEQ 586
Query: 150 RRREKAEELAAR-QRVREKIERDKAER 175
+ EK +++ + ++ EK E+ K ER
Sbjct: 587 MKEEKKKQIEQKFAQIDEKTEKAKEER 613
>gi|56549694 enabled homolog isoform a [Homo sapiens]
Length = 591
Score = 58.2 bits (139), Expect = 9e-09
Identities = 34/98 (34%), Positives = 62/98 (63%), Gaps = 7/98 (7%)
Query: 87 SEEERQEQTKRMLELVAQKQREREEREEREALERERQRRRQGQELSAARQRLQEDEMRRA 146
S+EE + Q +++ E QK+ ERE R ERE +ERER R + + R+RL+++++ R
Sbjct: 136 SQEELEIQRRQLQEQQRQKELERE-RLERERMERERLERERLERERLERERLEQEQLERE 194
Query: 147 AEERRR----EKAEELAARQRV--REKIERDKAERAKK 178
+ER R E+ E L ++R+ +E+++R++ ER ++
Sbjct: 195 RQERERQERLERQERLERQERLERQERLDRERQERQER 232
Score = 54.7 bits (130), Expect = 1e-07
Identities = 34/96 (35%), Positives = 56/96 (58%), Gaps = 8/96 (8%)
Query: 86 LSEEERQEQTKRMLELVAQKQREREERE--EREALERERQRRRQGQELSAARQRLQEDEM 143
L E++RQ++ +R + +RER ERE ERE LERER R + ++ R+R + +
Sbjct: 147 LQEQQRQKELER-----ERLERERMERERLERERLERERLERERLEQEQLERERQERERQ 201
Query: 144 RRAAEERRREKAEELAARQRV-REKIERDKAERAKK 178
R + R E+ E L ++R+ RE+ ER + ER ++
Sbjct: 202 ERLERQERLERQERLERQERLDRERQERQERERLER 237
Score = 53.5 bits (127), Expect = 2e-07
Identities = 43/134 (32%), Positives = 62/134 (46%), Gaps = 13/134 (9%)
Query: 88 EEERQEQTKRMLELVAQKQREREEREEREALER-ERQRRRQGQELSAARQRLQEDEMRRA 146
E ER E+ + E + Q+Q ER ER+ERE ER ERQ R + QE ++RL + R
Sbjct: 172 ERERLERERLERERLEQEQLER-ERQERERQERLERQERLERQERLERQERLDRERQERQ 230
Query: 147 AEER----RREKAEELAARQRVREKIERDKAERAKKYGGSVGSQPP-------PVAPEPG 195
ER RE+ E Q RE++E ++ R + P A EPG
Sbjct: 231 ERERLERLERERQERERQEQLEREQLEWERERRISSAAAPASVETPLNSVLGDSSASEPG 290
Query: 196 PVPSSPSQEPPTKR 209
+S E P+++
Sbjct: 291 LQAASQPAETPSQQ 304
Score = 50.8 bits (120), Expect = 2e-06
Identities = 38/129 (29%), Positives = 54/129 (41%), Gaps = 13/129 (10%)
Query: 88 EEERQEQTKRMLELVAQKQREREEREEREALERERQRRRQGQELSAARQRLQEDEMRRAA 147
E ERQE+ +R L Q++ ER+ER +RE ER+ + R + E + QE R
Sbjct: 197 ERERQERLERQERLERQERLERQERLDRERQERQERERLERLERERQERERQEQLEREQL 256
Query: 148 EERRREKAEELAARQRVREKIERDKAE-RAKKYGGSVGSQP------------PPVAPEP 194
E R + AA V + + A + G SQP P P P
Sbjct: 257 EWERERRISSAAAPASVETPLNSVLGDSSASEPGLQAASQPAETPSQQGIVLGPLAPPPP 316
Query: 195 GPVPSSPSQ 203
P+P P+Q
Sbjct: 317 PPLPPGPAQ 325
Score = 49.7 bits (117), Expect = 3e-06
Identities = 41/137 (29%), Positives = 65/137 (47%), Gaps = 13/137 (9%)
Query: 81 EGKPALSEEERQEQTKRMLELVAQKQREREEREEREALER-ERQRRRQGQELSAARQRLQ 139
E + L +ER E+ +R LE + RER+ER+ERE LER ER+R+ + ++ R++L+
Sbjct: 199 ERQERLERQERLERQER-LERQERLDRERQERQERERLERLERERQERERQEQLEREQLE 257
Query: 140 EDEMRRAAEERRREKAEEL-------AARQRVREKIERDKAERAKKYG---GSVGSQPPP 189
+ RR + E ++ + AE + G G + PPP
Sbjct: 258 WERERRISSAAAPASVETPLNSVLGDSSASEPGLQAASQPAETPSQQGIVLGPLAPPPPP 317
Query: 190 VAPEPGPVPSSPSQEPP 206
P PGP +S + PP
Sbjct: 318 PLP-PGPAQASVALPPP 333
Score = 42.7 bits (99), Expect = 4e-04
Identities = 27/94 (28%), Positives = 50/94 (53%), Gaps = 2/94 (2%)
Query: 87 SEEERQEQTKRMLELVAQKQR--EREEREEREALERERQRRRQGQELSAARQRLQEDEMR 144
S+E ++ +L AQ Q +EE E + +E+QR+++ + R+R++ + +
Sbjct: 113 SQETGPTLPRQNSQLPAQVQNGPSQEELEIQRRQLQEQQRQKELERERLERERMERERLE 172
Query: 145 RAAEERRREKAEELAARQRVREKIERDKAERAKK 178
R ER R + E L Q RE+ ER++ ER ++
Sbjct: 173 RERLERERLERERLEQEQLERERQERERQERLER 206
Score = 34.3 bits (77), Expect = 0.15
Identities = 20/79 (25%), Positives = 40/79 (50%), Gaps = 1/79 (1%)
Query: 99 LELVAQKQREREEREEREALERERQRRRQGQELSAARQRLQEDEMRRAAEERRREKAEEL 158
LE++ ++ + L + Q +EL R++LQE + ++ E R E+ E +
Sbjct: 108 LEVLNSQETGPTLPRQNSQLPAQVQNGPSQEELEIQRRQLQEQQRQKELERERLER-ERM 166
Query: 159 AARQRVREKIERDKAERAK 177
+ RE++ER++ ER +
Sbjct: 167 ERERLERERLERERLERER 185
>gi|39930375 enabled homolog isoform b [Homo sapiens]
Length = 570
Score = 58.2 bits (139), Expect = 9e-09
Identities = 34/98 (34%), Positives = 62/98 (63%), Gaps = 7/98 (7%)
Query: 87 SEEERQEQTKRMLELVAQKQREREEREEREALERERQRRRQGQELSAARQRLQEDEMRRA 146
S+EE + Q +++ E QK+ ERE R ERE +ERER R + + R+RL+++++ R
Sbjct: 136 SQEELEIQRRQLQEQQRQKELERE-RLERERMERERLERERLERERLERERLEQEQLERE 194
Query: 147 AEERRR----EKAEELAARQRV--REKIERDKAERAKK 178
+ER R E+ E L ++R+ +E+++R++ ER ++
Sbjct: 195 RQERERQERLERQERLERQERLERQERLDRERQERQER 232
Score = 54.7 bits (130), Expect = 1e-07
Identities = 34/96 (35%), Positives = 56/96 (58%), Gaps = 8/96 (8%)
Query: 86 LSEEERQEQTKRMLELVAQKQREREERE--EREALERERQRRRQGQELSAARQRLQEDEM 143
L E++RQ++ +R + +RER ERE ERE LERER R + ++ R+R + +
Sbjct: 147 LQEQQRQKELER-----ERLERERMERERLERERLERERLERERLEQEQLERERQERERQ 201
Query: 144 RRAAEERRREKAEELAARQRV-REKIERDKAERAKK 178
R + R E+ E L ++R+ RE+ ER + ER ++
Sbjct: 202 ERLERQERLERQERLERQERLDRERQERQERERLER 237
Score = 53.5 bits (127), Expect = 2e-07
Identities = 43/134 (32%), Positives = 62/134 (46%), Gaps = 13/134 (9%)
Query: 88 EEERQEQTKRMLELVAQKQREREEREEREALER-ERQRRRQGQELSAARQRLQEDEMRRA 146
E ER E+ + E + Q+Q ER ER+ERE ER ERQ R + QE ++RL + R
Sbjct: 172 ERERLERERLERERLEQEQLER-ERQERERQERLERQERLERQERLERQERLDRERQERQ 230
Query: 147 AEER----RREKAEELAARQRVREKIERDKAERAKKYGGSVGSQPP-------PVAPEPG 195
ER RE+ E Q RE++E ++ R + P A EPG
Sbjct: 231 ERERLERLERERQERERQEQLEREQLEWERERRISSAAAPASVETPLNSVLGDSSASEPG 290
Query: 196 PVPSSPSQEPPTKR 209
+S E P+++
Sbjct: 291 LQAASQPAETPSQQ 304
Score = 50.8 bits (120), Expect = 2e-06
Identities = 38/129 (29%), Positives = 54/129 (41%), Gaps = 13/129 (10%)
Query: 88 EEERQEQTKRMLELVAQKQREREEREEREALERERQRRRQGQELSAARQRLQEDEMRRAA 147
E ERQE+ +R L Q++ ER+ER +RE ER+ + R + E + QE R
Sbjct: 197 ERERQERLERQERLERQERLERQERLDRERQERQERERLERLERERQERERQEQLEREQL 256
Query: 148 EERRREKAEELAARQRVREKIERDKAE-RAKKYGGSVGSQP------------PPVAPEP 194
E R + AA V + + A + G SQP P P P
Sbjct: 257 EWERERRISSAAAPASVETPLNSVLGDSSASEPGLQAASQPAETPSQQGIVLGPLAPPPP 316
Query: 195 GPVPSSPSQ 203
P+P P+Q
Sbjct: 317 PPLPPGPAQ 325
Score = 49.7 bits (117), Expect = 3e-06
Identities = 41/137 (29%), Positives = 65/137 (47%), Gaps = 13/137 (9%)
Query: 81 EGKPALSEEERQEQTKRMLELVAQKQREREEREEREALER-ERQRRRQGQELSAARQRLQ 139
E + L +ER E+ +R LE + RER+ER+ERE LER ER+R+ + ++ R++L+
Sbjct: 199 ERQERLERQERLERQER-LERQERLDRERQERQERERLERLERERQERERQEQLEREQLE 257
Query: 140 EDEMRRAAEERRREKAEEL-------AARQRVREKIERDKAERAKKYG---GSVGSQPPP 189
+ RR + E ++ + AE + G G + PPP
Sbjct: 258 WERERRISSAAAPASVETPLNSVLGDSSASEPGLQAASQPAETPSQQGIVLGPLAPPPPP 317
Query: 190 VAPEPGPVPSSPSQEPP 206
P PGP +S + PP
Sbjct: 318 PLP-PGPAQASVALPPP 333
Score = 42.7 bits (99), Expect = 4e-04
Identities = 27/94 (28%), Positives = 50/94 (53%), Gaps = 2/94 (2%)
Query: 87 SEEERQEQTKRMLELVAQKQR--EREEREEREALERERQRRRQGQELSAARQRLQEDEMR 144
S+E ++ +L AQ Q +EE E + +E+QR+++ + R+R++ + +
Sbjct: 113 SQETGPTLPRQNSQLPAQVQNGPSQEELEIQRRQLQEQQRQKELERERLERERMERERLE 172
Query: 145 RAAEERRREKAEELAARQRVREKIERDKAERAKK 178
R ER R + E L Q RE+ ER++ ER ++
Sbjct: 173 RERLERERLERERLEQEQLERERQERERQERLER 206
Score = 34.3 bits (77), Expect = 0.15
Identities = 20/79 (25%), Positives = 40/79 (50%), Gaps = 1/79 (1%)
Query: 99 LELVAQKQREREEREEREALERERQRRRQGQELSAARQRLQEDEMRRAAEERRREKAEEL 158
LE++ ++ + L + Q +EL R++LQE + ++ E R E+ E +
Sbjct: 108 LEVLNSQETGPTLPRQNSQLPAQVQNGPSQEELEIQRRQLQEQQRQKELERERLER-ERM 166
Query: 159 AARQRVREKIERDKAERAK 177
+ RE++ER++ ER +
Sbjct: 167 ERERLERERLERERLERER 185
>gi|156766047 GRB10 interacting GYF protein 2 isoform c [Homo
sapiens]
Length = 1293
Score = 57.0 bits (136), Expect = 2e-08
Identities = 43/140 (30%), Positives = 68/140 (48%), Gaps = 7/140 (5%)
Query: 46 PDVDEPLETP-LGHILGREPTSSEQGGLEGSGS---AAGEGKPALSEEERQEQTKRMLEL 101
P V + P G I +PT+S+ EG P + E+ Q+ K
Sbjct: 671 PSVTRSVSVPDTGSIWELQPTASQPTVWEGGSVWDLPLDTTTPGPALEQLQQLEKAKAAK 730
Query: 102 VAQKQREREEREEREALERERQRRRQGQELSAARQRLQEDEMRRAAEERRREKAEELAAR 161
+ Q++RE E R +RE ER+RQ + Q+ R++ +E+ RR EE R K EE R
Sbjct: 731 LEQERREAEMRAKREEEERKRQEELRRQQEEILRRQQEEERKRREEEELARRKQEEALRR 790
Query: 162 QRVRE---KIERDKAERAKK 178
QR +E + +R++ ER ++
Sbjct: 791 QREQEIALRRQREEEERQQQ 810
Score = 55.5 bits (132), Expect = 6e-08
Identities = 39/89 (43%), Positives = 54/89 (60%), Gaps = 7/89 (7%)
Query: 88 EEERQEQTKRMLELVAQKQREREEREEREALERERQRRRQGQELSAARQRLQEDEMRRAA 147
E +RQE+ +R E + ++Q+E EER+ RE E E RR+Q + L RQR QE +RR
Sbjct: 748 ERKRQEELRRQQEEILRRQQE-EERKRRE--EEELARRKQEEALR--RQREQEIALRRQR 802
Query: 148 EERRREKAEELAAR--QRVREKIERDKAE 174
EE R++ EE R +R RE+ ER K E
Sbjct: 803 EEEERQQQEEALRRLEERRREEEERRKQE 831
Score = 51.2 bits (121), Expect = 1e-06
Identities = 39/118 (33%), Positives = 61/118 (51%), Gaps = 11/118 (9%)
Query: 68 EQGGLEGSGSAAGEGKPALSEEERQEQTKRMLELVAQKQREREEREEREALERERQRRRQ 127
EQ E A E + +EE + Q + +L +++R+R E EE ++E RRQ
Sbjct: 732 EQERREAEMRAKREEEERKRQEELRRQQEEILRRQQEEERKRREEEELARRKQEEALRRQ 791
Query: 128 -GQELSAARQ-----RLQEDEMRRAAEERRREKAEELAARQRVREKIERDKAERAKKY 179
QE++ RQ R Q++E R EERRRE+ E +R +E++ R + E A K+
Sbjct: 792 REQEIALRRQREEEERQQQEEALRRLEERRREEEE-----RRKQEELLRKQEEEAAKW 844
Score = 49.7 bits (117), Expect = 3e-06
Identities = 33/98 (33%), Positives = 57/98 (58%), Gaps = 6/98 (6%)
Query: 81 EGKPALSEEERQEQTKRMLELVAQKQREREEREERE-ALERERQRRRQGQELSAARQRLQ 139
E + A ++E + +R E+ ++QRE EER+++E AL R +RRR+ +E +R Q
Sbjct: 776 EEELARRKQEEALRRQREQEIALRRQREEEERQQQEEALRRLEERRREEEE-----RRKQ 830
Query: 140 EDEMRRAAEERRREKAEELAARQRVREKIERDKAERAK 177
E+ +R+ EE + EE A++R+ E R + E A+
Sbjct: 831 EELLRKQEEEAAKWAREEEEAQRRLEENRLRMEEEAAR 868
Score = 49.3 bits (116), Expect = 4e-06
Identities = 30/86 (34%), Positives = 49/86 (56%), Gaps = 3/86 (3%)
Query: 88 EEERQEQTKRMLELVAQKQREREEREEREALERERQ---RRRQGQELSAARQRLQEDEMR 144
EEER+ + + L Q++ R +RE+ AL R+R+ R++Q + L +R +E+E R
Sbjct: 768 EEERKRREEEELARRKQEEALRRQREQEIALRRQREEEERQQQEEALRRLEERRREEEER 827
Query: 145 RAAEERRREKAEELAARQRVREKIER 170
R EE R++ EE A R E+ +R
Sbjct: 828 RKQEELLRKQEEEAAKWAREEEEAQR 853
Score = 47.4 bits (111), Expect = 2e-05
Identities = 29/87 (33%), Positives = 47/87 (54%), Gaps = 7/87 (8%)
Query: 88 EEERQEQTKRMLELVAQKQREREEREEREALERERQRRRQGQELSAARQRLQEDEMRRAA 147
EEE ++Q + L + +++RE EER ++E L R+ QE AA+ +E+E +R
Sbjct: 803 EEEERQQQEEALRRLEERRREEEERRKQEELLRK-------QEEEAAKWAREEEEAQRRL 855
Query: 148 EERRREKAEELAARQRVREKIERDKAE 174
EE R EE A + E+ +R + E
Sbjct: 856 EENRLRMEEEAARLRHEEEERKRKELE 882
Score = 46.6 bits (109), Expect = 3e-05
Identities = 29/104 (27%), Positives = 54/104 (51%), Gaps = 6/104 (5%)
Query: 81 EGKPALSEEERQEQTKRMLELVAQKQRERE-EREEREALERERQRRRQGQELSAARQRLQ 139
+ K A E+ER+E R +++R+ E R++ E L R+++ R+ +E +R Q
Sbjct: 725 KAKAAKLEQERREAEMRAKREEEERKRQEELRRQQEEILRRQQEEERKRREEEELARRKQ 784
Query: 140 EDEMRRAAEE-----RRREKAEELAARQRVREKIERDKAERAKK 178
E+ +RR E+ R+RE+ E + +R ER + E ++
Sbjct: 785 EEALRRQREQEIALRRQREEEERQQQEEALRRLEERRREEEERR 828
Score = 44.7 bits (104), Expect = 1e-04
Identities = 32/88 (36%), Positives = 49/88 (55%), Gaps = 5/88 (5%)
Query: 86 LSEEERQEQTKRMLELVAQKQRE---REEREEREALERERQRRRQGQELSAARQRLQEDE 142
L E R+E+ +R E + +KQ E + REE EA +R + R E AAR R +E+E
Sbjct: 817 LEERRREEEERRKQEELLRKQEEEAAKWAREEEEA-QRRLEENRLRMEEEAARLRHEEEE 875
Query: 143 MRRAAEERRREKAEELAARQRVREKIER 170
+R E +R+K E + RQ+ +E + R
Sbjct: 876 RKRKELEVQRQK-ELMRQRQQQQEALRR 902
Score = 42.0 bits (97), Expect = 7e-04
Identities = 30/113 (26%), Positives = 58/113 (51%), Gaps = 26/113 (23%)
Query: 81 EGKPALSEEERQEQTKRMLELVAQKQREREEREEREALERERQRRRQGQ----------- 129
E + A E +E+ ++ LE+ QK+ R+ ++++EAL R +Q+++Q Q
Sbjct: 863 EEEAARLRHEEEERKRKELEVQRQKELMRQRQQQQEALRRLQQQQQQQQLAQMKLPSSST 922
Query: 130 --------------ELSAAR-QRLQEDEMRRAAEERRREKAEELAARQRVREK 167
LS A Q+L+E+ R+ EE+RR++ E + A Q+ +++
Sbjct: 923 WGQQSNTTACQSQATLSLAEIQKLEEERERQLREEQRRQQRELMKALQQQQQQ 975
Score = 33.5 bits (75), Expect = 0.25
Identities = 23/73 (31%), Positives = 39/73 (53%), Gaps = 6/73 (8%)
Query: 83 KPALSEEERQEQTKR-MLELVAQKQREREEREEREALERERQRRRQGQELSAARQRLQED 141
K A EEE Q + + L + + R R E EER+ E E QR+++ RQR Q+
Sbjct: 843 KWAREEEEAQRRLEENRLRMEEEAARLRHEEEERKRKELEVQRQKE-----LMRQRQQQQ 897
Query: 142 EMRRAAEERRREK 154
E R +++++++
Sbjct: 898 EALRRLQQQQQQQ 910
Score = 30.4 bits (67), Expect = 2.1
Identities = 22/101 (21%), Positives = 47/101 (46%), Gaps = 25/101 (24%)
Query: 113 EEREALERERQRRRQGQELSAARQRLQEDEMR--------------RAAEERRREKAEEL 158
EERE RE QRR+Q + + A +Q+ Q+ + + ++ E ++E+A ++
Sbjct: 948 EERERQLREEQRRQQRELMKALQQQQQQQQQKLSGWGNVSKPSGTTKSLLEIQQEEARQM 1007
Query: 159 AARQRVREKIERDKAERAKKYG-----------GSVGSQPP 188
+Q+ +++ ++ R + GS+ + PP
Sbjct: 1008 QKQQQQQQQHQQPNRARNNTHSNLHTSIGNSVWGSINTGPP 1048
>gi|156766045 GRB10 interacting GYF protein 2 isoform a [Homo
sapiens]
Length = 1320
Score = 57.0 bits (136), Expect = 2e-08
Identities = 43/140 (30%), Positives = 68/140 (48%), Gaps = 7/140 (5%)
Query: 46 PDVDEPLETP-LGHILGREPTSSEQGGLEGSGS---AAGEGKPALSEEERQEQTKRMLEL 101
P V + P G I +PT+S+ EG P + E+ Q+ K
Sbjct: 698 PSVTRSVSVPDTGSIWELQPTASQPTVWEGGSVWDLPLDTTTPGPALEQLQQLEKAKAAK 757
Query: 102 VAQKQREREEREEREALERERQRRRQGQELSAARQRLQEDEMRRAAEERRREKAEELAAR 161
+ Q++RE E R +RE ER+RQ + Q+ R++ +E+ RR EE R K EE R
Sbjct: 758 LEQERREAEMRAKREEEERKRQEELRRQQEEILRRQQEEERKRREEEELARRKQEEALRR 817
Query: 162 QRVRE---KIERDKAERAKK 178
QR +E + +R++ ER ++
Sbjct: 818 QREQEIALRRQREEEERQQQ 837
Score = 55.5 bits (132), Expect = 6e-08
Identities = 39/89 (43%), Positives = 54/89 (60%), Gaps = 7/89 (7%)
Query: 88 EEERQEQTKRMLELVAQKQREREEREEREALERERQRRRQGQELSAARQRLQEDEMRRAA 147
E +RQE+ +R E + ++Q+E EER+ RE E E RR+Q + L RQR QE +RR
Sbjct: 775 ERKRQEELRRQQEEILRRQQE-EERKRRE--EEELARRKQEEALR--RQREQEIALRRQR 829
Query: 148 EERRREKAEELAAR--QRVREKIERDKAE 174
EE R++ EE R +R RE+ ER K E
Sbjct: 830 EEEERQQQEEALRRLEERRREEEERRKQE 858
Score = 51.2 bits (121), Expect = 1e-06
Identities = 39/118 (33%), Positives = 61/118 (51%), Gaps = 11/118 (9%)
Query: 68 EQGGLEGSGSAAGEGKPALSEEERQEQTKRMLELVAQKQREREEREEREALERERQRRRQ 127
EQ E A E + +EE + Q + +L +++R+R E EE ++E RRQ
Sbjct: 759 EQERREAEMRAKREEEERKRQEELRRQQEEILRRQQEEERKRREEEELARRKQEEALRRQ 818
Query: 128 -GQELSAARQ-----RLQEDEMRRAAEERRREKAEELAARQRVREKIERDKAERAKKY 179
QE++ RQ R Q++E R EERRRE+ E +R +E++ R + E A K+
Sbjct: 819 REQEIALRRQREEEERQQQEEALRRLEERRREEEE-----RRKQEELLRKQEEEAAKW 871
Score = 49.7 bits (117), Expect = 3e-06
Identities = 33/98 (33%), Positives = 57/98 (58%), Gaps = 6/98 (6%)
Query: 81 EGKPALSEEERQEQTKRMLELVAQKQREREEREERE-ALERERQRRRQGQELSAARQRLQ 139
E + A ++E + +R E+ ++QRE EER+++E AL R +RRR+ +E +R Q
Sbjct: 803 EEELARRKQEEALRRQREQEIALRRQREEEERQQQEEALRRLEERRREEEE-----RRKQ 857
Query: 140 EDEMRRAAEERRREKAEELAARQRVREKIERDKAERAK 177
E+ +R+ EE + EE A++R+ E R + E A+
Sbjct: 858 EELLRKQEEEAAKWAREEEEAQRRLEENRLRMEEEAAR 895
Score = 49.3 bits (116), Expect = 4e-06
Identities = 30/86 (34%), Positives = 49/86 (56%), Gaps = 3/86 (3%)
Query: 88 EEERQEQTKRMLELVAQKQREREEREEREALERERQ---RRRQGQELSAARQRLQEDEMR 144
EEER+ + + L Q++ R +RE+ AL R+R+ R++Q + L +R +E+E R
Sbjct: 795 EEERKRREEEELARRKQEEALRRQREQEIALRRQREEEERQQQEEALRRLEERRREEEER 854
Query: 145 RAAEERRREKAEELAARQRVREKIER 170
R EE R++ EE A R E+ +R
Sbjct: 855 RKQEELLRKQEEEAAKWAREEEEAQR 880
Score = 47.4 bits (111), Expect = 2e-05
Identities = 29/87 (33%), Positives = 47/87 (54%), Gaps = 7/87 (8%)
Query: 88 EEERQEQTKRMLELVAQKQREREEREEREALERERQRRRQGQELSAARQRLQEDEMRRAA 147
EEE ++Q + L + +++RE EER ++E L R+ QE AA+ +E+E +R
Sbjct: 830 EEEERQQQEEALRRLEERRREEEERRKQEELLRK-------QEEEAAKWAREEEEAQRRL 882
Query: 148 EERRREKAEELAARQRVREKIERDKAE 174
EE R EE A + E+ +R + E
Sbjct: 883 EENRLRMEEEAARLRHEEEERKRKELE 909
Score = 46.6 bits (109), Expect = 3e-05
Identities = 29/104 (27%), Positives = 54/104 (51%), Gaps = 6/104 (5%)
Query: 81 EGKPALSEEERQEQTKRMLELVAQKQRERE-EREEREALERERQRRRQGQELSAARQRLQ 139
+ K A E+ER+E R +++R+ E R++ E L R+++ R+ +E +R Q
Sbjct: 752 KAKAAKLEQERREAEMRAKREEEERKRQEELRRQQEEILRRQQEEERKRREEEELARRKQ 811
Query: 140 EDEMRRAAEE-----RRREKAEELAARQRVREKIERDKAERAKK 178
E+ +RR E+ R+RE+ E + +R ER + E ++
Sbjct: 812 EEALRRQREQEIALRRQREEEERQQQEEALRRLEERRREEEERR 855
Score = 44.7 bits (104), Expect = 1e-04
Identities = 32/88 (36%), Positives = 49/88 (55%), Gaps = 5/88 (5%)
Query: 86 LSEEERQEQTKRMLELVAQKQRE---REEREEREALERERQRRRQGQELSAARQRLQEDE 142
L E R+E+ +R E + +KQ E + REE EA +R + R E AAR R +E+E
Sbjct: 844 LEERRREEEERRKQEELLRKQEEEAAKWAREEEEA-QRRLEENRLRMEEEAARLRHEEEE 902
Query: 143 MRRAAEERRREKAEELAARQRVREKIER 170
+R E +R+K E + RQ+ +E + R
Sbjct: 903 RKRKELEVQRQK-ELMRQRQQQQEALRR 929
Score = 42.0 bits (97), Expect = 7e-04
Identities = 30/113 (26%), Positives = 58/113 (51%), Gaps = 26/113 (23%)
Query: 81 EGKPALSEEERQEQTKRMLELVAQKQREREEREEREALERERQRRRQGQ----------- 129
E + A E +E+ ++ LE+ QK+ R+ ++++EAL R +Q+++Q Q
Sbjct: 890 EEEAARLRHEEEERKRKELEVQRQKELMRQRQQQQEALRRLQQQQQQQQLAQMKLPSSST 949
Query: 130 --------------ELSAAR-QRLQEDEMRRAAEERRREKAEELAARQRVREK 167
LS A Q+L+E+ R+ EE+RR++ E + A Q+ +++
Sbjct: 950 WGQQSNTTACQSQATLSLAEIQKLEEERERQLREEQRRQQRELMKALQQQQQQ 1002
Score = 33.5 bits (75), Expect = 0.25
Identities = 23/73 (31%), Positives = 39/73 (53%), Gaps = 6/73 (8%)
Query: 83 KPALSEEERQEQTKR-MLELVAQKQREREEREEREALERERQRRRQGQELSAARQRLQED 141
K A EEE Q + + L + + R R E EER+ E E QR+++ RQR Q+
Sbjct: 870 KWAREEEEAQRRLEENRLRMEEEAARLRHEEEERKRKELEVQRQKE-----LMRQRQQQQ 924
Query: 142 EMRRAAEERRREK 154
E R +++++++
Sbjct: 925 EALRRLQQQQQQQ 937
Score = 30.4 bits (67), Expect = 2.1
Identities = 22/101 (21%), Positives = 47/101 (46%), Gaps = 25/101 (24%)
Query: 113 EEREALERERQRRRQGQELSAARQRLQEDEMR--------------RAAEERRREKAEEL 158
EERE RE QRR+Q + + A +Q+ Q+ + + ++ E ++E+A ++
Sbjct: 975 EERERQLREEQRRQQRELMKALQQQQQQQQQKLSGWGNVSKPSGTTKSLLEIQQEEARQM 1034
Query: 159 AARQRVREKIERDKAERAKKYG-----------GSVGSQPP 188
+Q+ +++ ++ R + GS+ + PP
Sbjct: 1035 QKQQQQQQQHQQPNRARNNTHSNLHTSIGNSVWGSINTGPP 1075
>gi|156766043 GRB10 interacting GYF protein 2 isoform b [Homo
sapiens]
Length = 1299
Score = 57.0 bits (136), Expect = 2e-08
Identities = 43/140 (30%), Positives = 68/140 (48%), Gaps = 7/140 (5%)
Query: 46 PDVDEPLETP-LGHILGREPTSSEQGGLEGSGS---AAGEGKPALSEEERQEQTKRMLEL 101
P V + P G I +PT+S+ EG P + E+ Q+ K
Sbjct: 677 PSVTRSVSVPDTGSIWELQPTASQPTVWEGGSVWDLPLDTTTPGPALEQLQQLEKAKAAK 736
Query: 102 VAQKQREREEREEREALERERQRRRQGQELSAARQRLQEDEMRRAAEERRREKAEELAAR 161
+ Q++RE E R +RE ER+RQ + Q+ R++ +E+ RR EE R K EE R
Sbjct: 737 LEQERREAEMRAKREEEERKRQEELRRQQEEILRRQQEEERKRREEEELARRKQEEALRR 796
Query: 162 QRVRE---KIERDKAERAKK 178
QR +E + +R++ ER ++
Sbjct: 797 QREQEIALRRQREEEERQQQ 816
Score = 55.5 bits (132), Expect = 6e-08
Identities = 39/89 (43%), Positives = 54/89 (60%), Gaps = 7/89 (7%)
Query: 88 EEERQEQTKRMLELVAQKQREREEREEREALERERQRRRQGQELSAARQRLQEDEMRRAA 147
E +RQE+ +R E + ++Q+E EER+ RE E E RR+Q + L RQR QE +RR
Sbjct: 754 ERKRQEELRRQQEEILRRQQE-EERKRRE--EEELARRKQEEALR--RQREQEIALRRQR 808
Query: 148 EERRREKAEELAAR--QRVREKIERDKAE 174
EE R++ EE R +R RE+ ER K E
Sbjct: 809 EEEERQQQEEALRRLEERRREEEERRKQE 837
Score = 51.2 bits (121), Expect = 1e-06
Identities = 39/118 (33%), Positives = 61/118 (51%), Gaps = 11/118 (9%)
Query: 68 EQGGLEGSGSAAGEGKPALSEEERQEQTKRMLELVAQKQREREEREEREALERERQRRRQ 127
EQ E A E + +EE + Q + +L +++R+R E EE ++E RRQ
Sbjct: 738 EQERREAEMRAKREEEERKRQEELRRQQEEILRRQQEEERKRREEEELARRKQEEALRRQ 797
Query: 128 -GQELSAARQ-----RLQEDEMRRAAEERRREKAEELAARQRVREKIERDKAERAKKY 179
QE++ RQ R Q++E R EERRRE+ E +R +E++ R + E A K+
Sbjct: 798 REQEIALRRQREEEERQQQEEALRRLEERRREEEE-----RRKQEELLRKQEEEAAKW 850
Score = 49.7 bits (117), Expect = 3e-06
Identities = 33/98 (33%), Positives = 57/98 (58%), Gaps = 6/98 (6%)
Query: 81 EGKPALSEEERQEQTKRMLELVAQKQREREEREERE-ALERERQRRRQGQELSAARQRLQ 139
E + A ++E + +R E+ ++QRE EER+++E AL R +RRR+ +E +R Q
Sbjct: 782 EEELARRKQEEALRRQREQEIALRRQREEEERQQQEEALRRLEERRREEEE-----RRKQ 836
Query: 140 EDEMRRAAEERRREKAEELAARQRVREKIERDKAERAK 177
E+ +R+ EE + EE A++R+ E R + E A+
Sbjct: 837 EELLRKQEEEAAKWAREEEEAQRRLEENRLRMEEEAAR 874
Score = 49.3 bits (116), Expect = 4e-06
Identities = 30/86 (34%), Positives = 49/86 (56%), Gaps = 3/86 (3%)
Query: 88 EEERQEQTKRMLELVAQKQREREEREEREALERERQ---RRRQGQELSAARQRLQEDEMR 144
EEER+ + + L Q++ R +RE+ AL R+R+ R++Q + L +R +E+E R
Sbjct: 774 EEERKRREEEELARRKQEEALRRQREQEIALRRQREEEERQQQEEALRRLEERRREEEER 833
Query: 145 RAAEERRREKAEELAARQRVREKIER 170
R EE R++ EE A R E+ +R
Sbjct: 834 RKQEELLRKQEEEAAKWAREEEEAQR 859
Score = 47.4 bits (111), Expect = 2e-05
Identities = 29/87 (33%), Positives = 47/87 (54%), Gaps = 7/87 (8%)
Query: 88 EEERQEQTKRMLELVAQKQREREEREEREALERERQRRRQGQELSAARQRLQEDEMRRAA 147
EEE ++Q + L + +++RE EER ++E L R+ QE AA+ +E+E +R
Sbjct: 809 EEEERQQQEEALRRLEERRREEEERRKQEELLRK-------QEEEAAKWAREEEEAQRRL 861
Query: 148 EERRREKAEELAARQRVREKIERDKAE 174
EE R EE A + E+ +R + E
Sbjct: 862 EENRLRMEEEAARLRHEEEERKRKELE 888
Score = 46.6 bits (109), Expect = 3e-05
Identities = 29/104 (27%), Positives = 54/104 (51%), Gaps = 6/104 (5%)
Query: 81 EGKPALSEEERQEQTKRMLELVAQKQRERE-EREEREALERERQRRRQGQELSAARQRLQ 139
+ K A E+ER+E R +++R+ E R++ E L R+++ R+ +E +R Q
Sbjct: 731 KAKAAKLEQERREAEMRAKREEEERKRQEELRRQQEEILRRQQEEERKRREEEELARRKQ 790
Query: 140 EDEMRRAAEE-----RRREKAEELAARQRVREKIERDKAERAKK 178
E+ +RR E+ R+RE+ E + +R ER + E ++
Sbjct: 791 EEALRRQREQEIALRRQREEEERQQQEEALRRLEERRREEEERR 834
Score = 44.7 bits (104), Expect = 1e-04
Identities = 32/88 (36%), Positives = 49/88 (55%), Gaps = 5/88 (5%)
Query: 86 LSEEERQEQTKRMLELVAQKQRE---REEREEREALERERQRRRQGQELSAARQRLQEDE 142
L E R+E+ +R E + +KQ E + REE EA +R + R E AAR R +E+E
Sbjct: 823 LEERRREEEERRKQEELLRKQEEEAAKWAREEEEA-QRRLEENRLRMEEEAARLRHEEEE 881
Query: 143 MRRAAEERRREKAEELAARQRVREKIER 170
+R E +R+K E + RQ+ +E + R
Sbjct: 882 RKRKELEVQRQK-ELMRQRQQQQEALRR 908
Score = 42.0 bits (97), Expect = 7e-04
Identities = 30/113 (26%), Positives = 58/113 (51%), Gaps = 26/113 (23%)
Query: 81 EGKPALSEEERQEQTKRMLELVAQKQREREEREEREALERERQRRRQGQ----------- 129
E + A E +E+ ++ LE+ QK+ R+ ++++EAL R +Q+++Q Q
Sbjct: 869 EEEAARLRHEEEERKRKELEVQRQKELMRQRQQQQEALRRLQQQQQQQQLAQMKLPSSST 928
Query: 130 --------------ELSAAR-QRLQEDEMRRAAEERRREKAEELAARQRVREK 167
LS A Q+L+E+ R+ EE+RR++ E + A Q+ +++
Sbjct: 929 WGQQSNTTACQSQATLSLAEIQKLEEERERQLREEQRRQQRELMKALQQQQQQ 981
Score = 33.5 bits (75), Expect = 0.25
Identities = 23/73 (31%), Positives = 39/73 (53%), Gaps = 6/73 (8%)
Query: 83 KPALSEEERQEQTKR-MLELVAQKQREREEREEREALERERQRRRQGQELSAARQRLQED 141
K A EEE Q + + L + + R R E EER+ E E QR+++ RQR Q+
Sbjct: 849 KWAREEEEAQRRLEENRLRMEEEAARLRHEEEERKRKELEVQRQKE-----LMRQRQQQQ 903
Query: 142 EMRRAAEERRREK 154
E R +++++++
Sbjct: 904 EALRRLQQQQQQQ 916
Score = 30.4 bits (67), Expect = 2.1
Identities = 22/101 (21%), Positives = 47/101 (46%), Gaps = 25/101 (24%)
Query: 113 EEREALERERQRRRQGQELSAARQRLQEDEMR--------------RAAEERRREKAEEL 158
EERE RE QRR+Q + + A +Q+ Q+ + + ++ E ++E+A ++
Sbjct: 954 EERERQLREEQRRQQRELMKALQQQQQQQQQKLSGWGNVSKPSGTTKSLLEIQQEEARQM 1013
Query: 159 AARQRVREKIERDKAERAKKYG-----------GSVGSQPP 188
+Q+ +++ ++ R + GS+ + PP
Sbjct: 1014 QKQQQQQQQHQQPNRARNNTHSNLHTSIGNSVWGSINTGPP 1054
>gi|42476299 GRB10 interacting GYF protein 2 isoform b [Homo
sapiens]
Length = 1299
Score = 57.0 bits (136), Expect = 2e-08
Identities = 43/140 (30%), Positives = 68/140 (48%), Gaps = 7/140 (5%)
Query: 46 PDVDEPLETP-LGHILGREPTSSEQGGLEGSGS---AAGEGKPALSEEERQEQTKRMLEL 101
P V + P G I +PT+S+ EG P + E+ Q+ K
Sbjct: 677 PSVTRSVSVPDTGSIWELQPTASQPTVWEGGSVWDLPLDTTTPGPALEQLQQLEKAKAAK 736
Query: 102 VAQKQREREEREEREALERERQRRRQGQELSAARQRLQEDEMRRAAEERRREKAEELAAR 161
+ Q++RE E R +RE ER+RQ + Q+ R++ +E+ RR EE R K EE R
Sbjct: 737 LEQERREAEMRAKREEEERKRQEELRRQQEEILRRQQEEERKRREEEELARRKQEEALRR 796
Query: 162 QRVRE---KIERDKAERAKK 178
QR +E + +R++ ER ++
Sbjct: 797 QREQEIALRRQREEEERQQQ 816
Score = 55.5 bits (132), Expect = 6e-08
Identities = 39/89 (43%), Positives = 54/89 (60%), Gaps = 7/89 (7%)
Query: 88 EEERQEQTKRMLELVAQKQREREEREEREALERERQRRRQGQELSAARQRLQEDEMRRAA 147
E +RQE+ +R E + ++Q+E EER+ RE E E RR+Q + L RQR QE +RR
Sbjct: 754 ERKRQEELRRQQEEILRRQQE-EERKRRE--EEELARRKQEEALR--RQREQEIALRRQR 808
Query: 148 EERRREKAEELAAR--QRVREKIERDKAE 174
EE R++ EE R +R RE+ ER K E
Sbjct: 809 EEEERQQQEEALRRLEERRREEEERRKQE 837
Score = 51.2 bits (121), Expect = 1e-06
Identities = 39/118 (33%), Positives = 61/118 (51%), Gaps = 11/118 (9%)
Query: 68 EQGGLEGSGSAAGEGKPALSEEERQEQTKRMLELVAQKQREREEREEREALERERQRRRQ 127
EQ E A E + +EE + Q + +L +++R+R E EE ++E RRQ
Sbjct: 738 EQERREAEMRAKREEEERKRQEELRRQQEEILRRQQEEERKRREEEELARRKQEEALRRQ 797
Query: 128 -GQELSAARQ-----RLQEDEMRRAAEERRREKAEELAARQRVREKIERDKAERAKKY 179
QE++ RQ R Q++E R EERRRE+ E +R +E++ R + E A K+
Sbjct: 798 REQEIALRRQREEEERQQQEEALRRLEERRREEEE-----RRKQEELLRKQEEEAAKW 850
Score = 49.7 bits (117), Expect = 3e-06
Identities = 33/98 (33%), Positives = 57/98 (58%), Gaps = 6/98 (6%)
Query: 81 EGKPALSEEERQEQTKRMLELVAQKQREREEREERE-ALERERQRRRQGQELSAARQRLQ 139
E + A ++E + +R E+ ++QRE EER+++E AL R +RRR+ +E +R Q
Sbjct: 782 EEELARRKQEEALRRQREQEIALRRQREEEERQQQEEALRRLEERRREEEE-----RRKQ 836
Query: 140 EDEMRRAAEERRREKAEELAARQRVREKIERDKAERAK 177
E+ +R+ EE + EE A++R+ E R + E A+
Sbjct: 837 EELLRKQEEEAAKWAREEEEAQRRLEENRLRMEEEAAR 874
Score = 49.3 bits (116), Expect = 4e-06
Identities = 30/86 (34%), Positives = 49/86 (56%), Gaps = 3/86 (3%)
Query: 88 EEERQEQTKRMLELVAQKQREREEREEREALERERQ---RRRQGQELSAARQRLQEDEMR 144
EEER+ + + L Q++ R +RE+ AL R+R+ R++Q + L +R +E+E R
Sbjct: 774 EEERKRREEEELARRKQEEALRRQREQEIALRRQREEEERQQQEEALRRLEERRREEEER 833
Query: 145 RAAEERRREKAEELAARQRVREKIER 170
R EE R++ EE A R E+ +R
Sbjct: 834 RKQEELLRKQEEEAAKWAREEEEAQR 859
Score = 47.4 bits (111), Expect = 2e-05
Identities = 29/87 (33%), Positives = 47/87 (54%), Gaps = 7/87 (8%)
Query: 88 EEERQEQTKRMLELVAQKQREREEREEREALERERQRRRQGQELSAARQRLQEDEMRRAA 147
EEE ++Q + L + +++RE EER ++E L R+ QE AA+ +E+E +R
Sbjct: 809 EEEERQQQEEALRRLEERRREEEERRKQEELLRK-------QEEEAAKWAREEEEAQRRL 861
Query: 148 EERRREKAEELAARQRVREKIERDKAE 174
EE R EE A + E+ +R + E
Sbjct: 862 EENRLRMEEEAARLRHEEEERKRKELE 888
Score = 46.6 bits (109), Expect = 3e-05
Identities = 29/104 (27%), Positives = 54/104 (51%), Gaps = 6/104 (5%)
Query: 81 EGKPALSEEERQEQTKRMLELVAQKQRERE-EREEREALERERQRRRQGQELSAARQRLQ 139
+ K A E+ER+E R +++R+ E R++ E L R+++ R+ +E +R Q
Sbjct: 731 KAKAAKLEQERREAEMRAKREEEERKRQEELRRQQEEILRRQQEEERKRREEEELARRKQ 790
Query: 140 EDEMRRAAEE-----RRREKAEELAARQRVREKIERDKAERAKK 178
E+ +RR E+ R+RE+ E + +R ER + E ++
Sbjct: 791 EEALRRQREQEIALRRQREEEERQQQEEALRRLEERRREEEERR 834
Score = 44.7 bits (104), Expect = 1e-04
Identities = 32/88 (36%), Positives = 49/88 (55%), Gaps = 5/88 (5%)
Query: 86 LSEEERQEQTKRMLELVAQKQRE---REEREEREALERERQRRRQGQELSAARQRLQEDE 142
L E R+E+ +R E + +KQ E + REE EA +R + R E AAR R +E+E
Sbjct: 823 LEERRREEEERRKQEELLRKQEEEAAKWAREEEEA-QRRLEENRLRMEEEAARLRHEEEE 881
Query: 143 MRRAAEERRREKAEELAARQRVREKIER 170
+R E +R+K E + RQ+ +E + R
Sbjct: 882 RKRKELEVQRQK-ELMRQRQQQQEALRR 908
Score = 42.0 bits (97), Expect = 7e-04
Identities = 30/113 (26%), Positives = 58/113 (51%), Gaps = 26/113 (23%)
Query: 81 EGKPALSEEERQEQTKRMLELVAQKQREREEREEREALERERQRRRQGQ----------- 129
E + A E +E+ ++ LE+ QK+ R+ ++++EAL R +Q+++Q Q
Sbjct: 869 EEEAARLRHEEEERKRKELEVQRQKELMRQRQQQQEALRRLQQQQQQQQLAQMKLPSSST 928
Query: 130 --------------ELSAAR-QRLQEDEMRRAAEERRREKAEELAARQRVREK 167
LS A Q+L+E+ R+ EE+RR++ E + A Q+ +++
Sbjct: 929 WGQQSNTTACQSQATLSLAEIQKLEEERERQLREEQRRQQRELMKALQQQQQQ 981
Score = 33.5 bits (75), Expect = 0.25
Identities = 23/73 (31%), Positives = 39/73 (53%), Gaps = 6/73 (8%)
Query: 83 KPALSEEERQEQTKR-MLELVAQKQREREEREEREALERERQRRRQGQELSAARQRLQED 141
K A EEE Q + + L + + R R E EER+ E E QR+++ RQR Q+
Sbjct: 849 KWAREEEEAQRRLEENRLRMEEEAARLRHEEEERKRKELEVQRQKE-----LMRQRQQQQ 903
Query: 142 EMRRAAEERRREK 154
E R +++++++
Sbjct: 904 EALRRLQQQQQQQ 916
Score = 30.4 bits (67), Expect = 2.1
Identities = 22/101 (21%), Positives = 47/101 (46%), Gaps = 25/101 (24%)
Query: 113 EEREALERERQRRRQGQELSAARQRLQEDEMR--------------RAAEERRREKAEEL 158
EERE RE QRR+Q + + A +Q+ Q+ + + ++ E ++E+A ++
Sbjct: 954 EERERQLREEQRRQQRELMKALQQQQQQQQQKLSGWGNVSKPSGTTKSLLEIQQEEARQM 1013
Query: 159 AARQRVREKIERDKAERAKKYG-----------GSVGSQPP 188
+Q+ +++ ++ R + GS+ + PP
Sbjct: 1014 QKQQQQQQQHQQPNRARNNTHSNLHTSIGNSVWGSINTGPP 1054
>gi|22035604 mitogen-activated protein kinase kinase kinase kinase 4
isoform 2 [Homo sapiens]
Length = 1320
Score = 57.0 bits (136), Expect = 2e-08
Identities = 29/78 (37%), Positives = 53/78 (67%), Gaps = 2/78 (2%)
Query: 90 ERQEQTKRMLELVAQKQREREEREEREALERERQRRRQGQELSAARQRLQEDEMRRAAEE 149
E+Q++ +R LE +++RE ++ERE RE++ +R+ +EL R+R +E+E RRA EE
Sbjct: 400 EQQKEQRRRLEEQQRREREARRQQEREQRRREQEEKRRLEELE--RRRKEEEERRRAEEE 457
Query: 150 RRREKAEELAARQRVREK 167
+RR + E+ R+++ E+
Sbjct: 458 KRRVEREQEYIRRQLEEE 475
Score = 52.4 bits (124), Expect = 5e-07
Identities = 36/105 (34%), Positives = 58/105 (55%), Gaps = 16/105 (15%)
Query: 86 LSEEERQEQTKRMLELVAQKQR------------EREEREEREAL-ERERQRRRQGQELS 132
L E++ +EQ + +L+A++Q+ E ++R EREA ++ER++RR+ QE
Sbjct: 376 LQEQQLREQEEYKRQLLAERQKRIEQQKEQRRRLEEQQRREREARRQQEREQRRREQE-- 433
Query: 133 AARQRLQEDEMRRAAEERRREKAEELAARQRVREKIERDKAERAK 177
++RL+E E RR EE RR EE +R +E I R E +
Sbjct: 434 -EKRRLEELERRRKEEEERRRAEEEKRRVEREQEYIRRQLEEEQR 477
Score = 45.8 bits (107), Expect = 5e-05
Identities = 31/104 (29%), Positives = 55/104 (52%), Gaps = 14/104 (13%)
Query: 87 SEEERQ----------EQTKRMLELVAQKQ-REREEREEREALERERQRRRQGQELSAAR 135
SE R+ EQ + +L+A++Q R +++E+R LE +++R R+ +
Sbjct: 367 SEALRRQQLLQEQQLREQEEYKRQLLAERQKRIEQQKEQRRRLEEQQRREREARRQQERE 426
Query: 136 QRLQEDEMRRAAEERRREKAEELAARQRVREKIERDKAERAKKY 179
QR +E E +R EE R + EE +R R + E+ + ER ++Y
Sbjct: 427 QRRREQEEKRRLEELERRRKEE---EERRRAEEEKRRVEREQEY 467
Score = 44.7 bits (104), Expect = 1e-04
Identities = 36/103 (34%), Positives = 57/103 (55%), Gaps = 8/103 (7%)
Query: 81 EGKPALSEEERQEQTKRMLEL-VAQKQREREEREEREALERERQRRRQGQ---ELSAARQ 136
EG+P+ E T R L + Q+ +ER E R+ L +E+Q R Q + +L A RQ
Sbjct: 337 EGEPSSIVNVPGESTLRRDFLRLQQENKERSEALRRQQLLQEQQLREQEEYKRQLLAERQ 396
Query: 137 RL--QEDEMRRAAEERRREKAEELAARQRVREKIERDKAERAK 177
+ Q+ E RR EE++R + E A RQ+ RE+ R++ E+ +
Sbjct: 397 KRIEQQKEQRRRLEEQQRRERE--ARRQQEREQRRREQEEKRR 437
Score = 43.5 bits (101), Expect = 2e-04
Identities = 28/95 (29%), Positives = 52/95 (54%), Gaps = 7/95 (7%)
Query: 89 EERQEQTKRMLELVAQKQREREEREEREALERERQRR-----RQGQELSAARQRLQEDEM 143
+ER E +R + + Q+Q+ RE+ E + L ERQ+R Q + L ++R +E
Sbjct: 364 KERSEALRR--QQLLQEQQLREQEEYKRQLLAERQKRIEQQKEQRRRLEEQQRREREARR 421
Query: 144 RRAAEERRREKAEELAARQRVREKIERDKAERAKK 178
++ E+RRRE+ E+ + R + E ++ RA++
Sbjct: 422 QQEREQRRREQEEKRRLEELERRRKEEEERRRAEE 456
Score = 43.1 bits (100), Expect = 3e-04
Identities = 36/135 (26%), Positives = 68/135 (50%), Gaps = 12/135 (8%)
Query: 88 EEERQEQTKRMLELVAQKQREREER----EEREALERERQR-RRQGQELSAARQRLQEDE 142
+ R+++ KR LE + ++++E EER EE+ +ERE++ RRQ +E + LQ+
Sbjct: 427 QRRREQEEKRRLEELERRRKEEEERRRAEEEKRRVEREQEYIRRQLEEEQRHLEVLQQQL 486
Query: 143 MRRAAE--ERRREKAEELAARQRVREKIERDKA-----ERAKKYGGSVGSQPPPVAPEPG 195
++ A E R + EE +R++ ++++++A + + SQ PP +
Sbjct: 487 LQEQAMLLECRWREMEEHRQAERLQRQLQQEQAYLLSLQHDHRRPHPQHSQQPPPPQQER 546
Query: 196 PVPSSPSQEPPTKRE 210
PS + EP E
Sbjct: 547 SKPSFHAPEPKAHYE 561
Score = 42.4 bits (98), Expect = 5e-04
Identities = 28/109 (25%), Positives = 55/109 (50%), Gaps = 11/109 (10%)
Query: 81 EGKPALSEEERQEQTKRMLELVAQKQREREE-----------REEREALERERQRRRQGQ 129
E + L E++R+E+ R + Q++RE+EE +EE E E ++RR +
Sbjct: 404 EQRRRLEEQQRREREARRQQEREQRRREQEEKRRLEELERRRKEEEERRRAEEEKRRVER 463
Query: 130 ELSAARQRLQEDEMRRAAEERRREKAEELAARQRVREKIERDKAERAKK 178
E R++L+E++ +++ + + + R RE E +AER ++
Sbjct: 464 EQEYIRRQLEEEQRHLEVLQQQLLQEQAMLLECRWREMEEHRQAERLQR 512
>gi|22758136 MAP7 domain containing 2 [Homo sapiens]
Length = 732
Score = 57.0 bits (136), Expect = 2e-08
Identities = 55/197 (27%), Positives = 89/197 (45%), Gaps = 42/197 (21%)
Query: 7 LESLIEMGFPRGRAEK-----------ALALTGNQGIEAAMDWLMEHEDDPDVDEPLETP 55
L +L P+ +AEK A G QG EA L +H D E
Sbjct: 321 LPALSGQDMPKRKAEKEKSNKEREGTLAQQAAGPQGEEA----LEKHVVDKHASEKHAAA 376
Query: 56 LGHILGREPTSSEQGGLEGSGSAAGEGKPALSEEERQEQTKRMLELVAQKQREREEREER 115
G G+ S+ G + AGE L+E+ RQ + ++ E + ++E ++R ER
Sbjct: 377 AG---GKAENSAALGKPTAGTTDAGEAAKILAEKRRQARLQKEQEEQERVEKEEQDRLER 433
Query: 116 EALER----------------ERQRRRQGQELSAARQRLQEDEMRRAAEERRREKAEELA 159
E L+R E +R+RQ +E +++ + +E R+A EE +R+ EEL
Sbjct: 434 EELKRKAEEERLRLEEEARKQEEERKRQEEE----KKKQEGEEKRKAGEEAKRKAEEELL 489
Query: 160 ARQRVREKIERDKAERA 176
++EK E++K E+A
Sbjct: 490 ----LKEKQEQEKQEKA 502
Score = 49.3 bits (116), Expect = 4e-06
Identities = 42/142 (29%), Positives = 71/142 (50%), Gaps = 17/142 (11%)
Query: 57 GHILGREPTSSEQGGLEGSGSAAGEGKPALSEEERQEQTKRMLELVAQKQREREEREERE 116
G + +P QG G + + L++E R+E+ K +A ++++ E+++R
Sbjct: 31 GAVRTSQPNYRPQGM---EGFLKSDERQRLAKERREEREK----CLAAREQQILEKQKRA 83
Query: 117 ALERERQRRRQGQELSAARQRLQEDEMRRAAEERRREK--AEELAARQRVREKIER-DKA 173
L+ E+Q + ++L RQR ED+ R A EE+R++K EE +R +ER +
Sbjct: 84 RLQYEKQMEERWRKLEEQRQR--EDQKRAAVEEKRKQKLREEEERLEAMMRRSLERTQQL 141
Query: 174 ERAKKYGGSVGSQPPPVAPEPG 195
E KKY S P+A PG
Sbjct: 142 ELKKKY-----SWGAPLAIGPG 158
Score = 37.0 bits (84), Expect = 0.023
Identities = 34/145 (23%), Positives = 66/145 (45%), Gaps = 33/145 (22%)
Query: 79 AGEGKPALSEEERQEQTKRMLELVAQKQREREEREE---------------REALERERQ 123
A E + L EE R+++ +R + +K++E EE+ + +E E+E+Q
Sbjct: 440 AEEERLRLEEEARKQEEERKRQEEEKKKQEGEEKRKAGEEAKRKAEEELLLKEKQEQEKQ 499
Query: 124 RRRQGQELSAARQRLQEDEMRRAAEERRREKAEEL-AARQRVREKIERDKAERAKKYGGS 182
++ ++ + AAE + RE AE++ R+++ +IE+++ ER K+
Sbjct: 500 ------------EKAMIEKQKEAAETKAREVAEQMRLEREQIMLQIEQERLERKKRIDEI 547
Query: 183 V-----GSQPPPVAPEPGPVPSSPS 202
+ PP V E V P+
Sbjct: 548 MKRTRKSDVPPQVKKEDPKVGVQPA 572
Score = 33.9 bits (76), Expect = 0.19
Identities = 37/127 (29%), Positives = 56/127 (44%), Gaps = 24/127 (18%)
Query: 62 REPTSSEQGGLEGSGSAAGEGKPALSEEERQE-QTKRMLELVAQKQREREEREEREALER 120
+E + G E A E + L E++ QE Q K M+E KQ+E E + RE E+
Sbjct: 468 QEGEEKRKAGEEAKRKA--EEELLLKEKQEQEKQEKAMIE----KQKEAAETKAREVAEQ 521
Query: 121 ERQRRRQGQELSAARQRLQEDEMRRAAEERRREKAEELAARQRVREKIERDKAERAKKYG 180
R R Q L ++RL+ R+++ +E+ R R + D + KK
Sbjct: 522 MRLEREQIM-LQIEQERLE-----------RKKRIDEIMKRTR-----KSDVPPQVKKED 564
Query: 181 GSVGSQP 187
VG QP
Sbjct: 565 PKVGVQP 571
>gi|148746195 trichohyalin [Homo sapiens]
Length = 1943
Score = 56.2 bits (134), Expect = 4e-08
Identities = 35/102 (34%), Positives = 57/102 (55%), Gaps = 8/102 (7%)
Query: 83 KPALSEEERQEQTKRMLELVAQKQREREEREEREALERERQRRRQGQELSAARQRLQEDE 142
KPAL E+ R+EQ E +++ +REERE+R E+ERQ R + Q Q L+E+
Sbjct: 892 KPALQEQLRKEQQLLQEE---EEELQREEREKRRRQEQERQYREEEQLQQEEEQLLREER 948
Query: 143 MRRAAEERRREKAEELAARQRVREKI-----ERDKAERAKKY 179
+R +ER R+ ++ +Q+ + + +R + ER KKY
Sbjct: 949 EKRRRQERERQYRKDKKLQQKEEQLLGEEPEKRRRQEREKKY 990
Score = 55.5 bits (132), Expect = 6e-08
Identities = 33/102 (32%), Positives = 62/102 (60%), Gaps = 9/102 (8%)
Query: 83 KPALSEEERQEQTKRMLELVAQKQREREEREE----REALERERQRRRQGQELSAARQRL 138
K L ++ +E+ +R L+L +++RE++ER E RE ER QR ++ +E +QRL
Sbjct: 473 KQQLKRDQEEERRERWLKLEEEERREQQERREQQLRREQEERREQRLKRQEEEERLQQRL 532
Query: 139 Q-EDEMRRAAEERR----REKAEELAARQRVREKIERDKAER 175
+ E ++RR EERR + + E+ ++R ++++R++ ER
Sbjct: 533 RSEQQLRREQEERREQLLKREEEKRLEQERREQRLKREQEER 574
Score = 54.3 bits (129), Expect = 1e-07
Identities = 29/88 (32%), Positives = 53/88 (60%), Gaps = 3/88 (3%)
Query: 88 EEERQEQTKRMLELVAQKQREREEREEREALERERQRRRQGQELSAARQRLQEDEMRRAA 147
EE R++Q +R +L ++Q RE++ RE R Q+ R+ Q+L +Q +E ++RR
Sbjct: 370 EERREQQLRREQQLRREQQLRREQQLRREQQLRREQQLRREQQLRREQQLRREQQLRREQ 429
Query: 148 EERRREKAEELAARQRVREKIERDKAER 175
EE R E+ E ++R ++++R++ ER
Sbjct: 430 EEERHEQKHE---QERREQRLKREQEER 454
Score = 53.1 bits (126), Expect = 3e-07
Identities = 39/102 (38%), Positives = 58/102 (56%), Gaps = 11/102 (10%)
Query: 88 EEERQEQTKRMLELVAQK--------QREREEREEREALER-ERQR-RRQGQELSAARQR 137
EEE +E KR L ++ QR+RE +EE E L + ERQ RR+ QE +QR
Sbjct: 240 EEEEKEWRKRETVLRKEEEKLQEEEPQRQRELQEEEEQLRKLERQELRRERQEEEQQQQR 299
Query: 138 LQ-EDEMRRAAEERRREKAEELAARQRVREKIERDKAERAKK 178
L+ E ++RR EE RRE+ EE +Q RE+ E + ++ ++
Sbjct: 300 LRREQQLRRKQEEERREQQEERREQQERREQQEERREQQLRR 341
Score = 52.8 bits (125), Expect = 4e-07
Identities = 34/96 (35%), Positives = 53/96 (55%), Gaps = 14/96 (14%)
Query: 86 LSEEERQEQTKRMLELVAQKQREREEREEREA----LERER--QRRRQGQELSAARQRLQ 139
L EERQ++ +R L +K++ R +R ERE LE E QRR + Q+L LQ
Sbjct: 798 LRAEERQQREQRFLPEEEEKEQRRRQRREREKELQFLEEEEQLQRRERAQQLQEEEDGLQ 857
Query: 140 EDEMRRAAEERRREKAEELAARQRVREKIERDKAER 175
ED+ RR ++E+RR+ Q+ R ++E ++ R
Sbjct: 858 EDQERRRSQEQRRD--------QKWRWQLEEERKRR 885
Score = 52.0 bits (123), Expect = 7e-07
Identities = 31/91 (34%), Positives = 54/91 (59%), Gaps = 3/91 (3%)
Query: 88 EEERQEQTKRMLELVAQKQREREEREEREALERERQRRRQGQELSAARQRLQEDEMRRAA 147
EEE+Q+Q R + + +KQ E ER E++ RE+Q RR+ QE Q+L+ ++ R
Sbjct: 292 EEEQQQQRLRREQQLRRKQEE--ERREQQEERREQQERREQQE-ERREQQLRREQEERRE 348
Query: 148 EERRREKAEELAARQRVREKIERDKAERAKK 178
++ RRE+ EE +Q RE+ E + ++ ++
Sbjct: 349 QQLRREQEEERREQQLRREQEEERREQQLRR 379
Score = 51.6 bits (122), Expect = 9e-07
Identities = 33/95 (34%), Positives = 54/95 (56%), Gaps = 5/95 (5%)
Query: 88 EEERQEQTKRMLELVAQKQREREE----REEREALERERQRRRQGQELSAARQRLQEDEM 143
EEER +Q R + + ++Q ER E REE + LE+ER+ +R +E R +L + E
Sbjct: 524 EEERLQQRLRSEQQLRREQEERREQLLKREEEKRLEQERREQRLKREQEERRDQLLKREE 583
Query: 144 RRAAEERRREKAEELAARQRVREKIERDKAERAKK 178
R + +RE+ E L R + RE++ER + E ++
Sbjct: 584 ERRQQRLKREQEERLEQRLK-REEVERLEQEERRE 617
Score = 51.6 bits (122), Expect = 9e-07
Identities = 34/137 (24%), Positives = 72/137 (52%), Gaps = 4/137 (2%)
Query: 88 EEERQEQTKRMLELVAQKQREREEREEREA-LERERQRRRQG---QELSAARQRLQEDEM 143
++ R+EQ +R +L+ +++ +R E+E RE L+RE++ RR +E +QRL+ ++
Sbjct: 536 QQLRREQEERREQLLKREEEKRLEQERREQRLKREQEERRDQLLKREEERRQQRLKREQE 595
Query: 144 RRAAEERRREKAEELAARQRVREKIERDKAERAKKYGGSVGSQPPPVAPEPGPVPSSPSQ 203
R + +RE+ E L +R ++++R++ E ++ + + +
Sbjct: 596 ERLEQRLKREEVERLEQEERREQRLKREEPEEERRQQLLKSEEQEERRQQQLRREQQERR 655
Query: 204 EPPTKREYDQCRIQVRL 220
E KRE ++ R++ RL
Sbjct: 656 EQRLKREEEEERLEQRL 672
Score = 51.2 bits (121), Expect = 1e-06
Identities = 28/91 (30%), Positives = 51/91 (56%), Gaps = 2/91 (2%)
Query: 88 EEERQEQTKRMLELVAQKQREREEREEREALERERQRRRQGQELSAARQRLQEDEMRRAA 147
EEER+EQ + E Q++RE++E + L RE++ RR+ Q + +E ++RR
Sbjct: 311 EEERREQQEERRE--QQERREQQEERREQQLRREQEERREQQLRREQEEERREQQLRREQ 368
Query: 148 EERRREKAEELAARQRVREKIERDKAERAKK 178
EE RRE+ + R +++ R++ R ++
Sbjct: 369 EEERREQQLRREQQLRREQQLRREQQLRREQ 399
Score = 50.8 bits (120), Expect = 2e-06
Identities = 64/220 (29%), Positives = 95/220 (43%), Gaps = 25/220 (11%)
Query: 86 LSEEERQEQTKRMLELVAQKQREREE-REEREALERERQRRRQGQELSAARQRLQEDEMR 144
L EEE Q Q + E ++ ER+E R ER+ E+++QR R+ Q+L +R QE+E R
Sbjct: 260 LQEEEPQRQRELQEEEEQLRKLERQELRRERQEEEQQQQRLRREQQL----RRKQEEERR 315
Query: 145 RAAEERR-----REKAEELAARQRVREKIERDKAERAKKYGGSVGSQPPPVAPEPGPVPS 199
EERR RE+ EE +Q RE+ ER + + ++ Q E
Sbjct: 316 EQQEERREQQERREQQEERREQQLRREQEERREQQLRREQEEERREQQLRREQEEERREQ 375
Query: 200 SPSQEPPTKREYDQCR-IQVRLPDGTSLTQTFRAREQLAAVRLYVELHRGEELGGGQDPV 258
+E +RE R Q+R Q R +QL R +L R ++L Q+
Sbjct: 376 QLRREQQLRREQQLRREQQLRREQQLRREQQLRREQQL---RREQQLRREQQLRREQE-- 430
Query: 259 QLLSGFPRRAFSEADMERPLQELGMAARLETRTRNWGSRE 298
R + + ER Q L R + R+W RE
Sbjct: 431 ------EERHEQKHEQERREQRL---KREQEERRDWLKRE 461
Score = 50.4 bits (119), Expect = 2e-06
Identities = 30/102 (29%), Positives = 53/102 (51%), Gaps = 4/102 (3%)
Query: 81 EGKPALSEEERQEQTKRMLELVAQKQREREEREEREALERER----QRRRQGQELSAARQ 136
E + L + ERQE + E Q+QR R E++ R E ER + RR+ QE ++
Sbjct: 273 EEEEQLRKLERQELRRERQEEEQQQQRLRREQQLRRKQEEERREQQEERREQQERREQQE 332
Query: 137 RLQEDEMRRAAEERRREKAEELAARQRVREKIERDKAERAKK 178
+E ++RR EERR ++ +R +++ R++ E ++
Sbjct: 333 ERREQQLRREQEERREQQLRREQEEERREQQLRREQEEERRE 374
Score = 49.7 bits (117), Expect = 3e-06
Identities = 36/120 (30%), Positives = 60/120 (50%), Gaps = 23/120 (19%)
Query: 71 GLEGSGSAAGEGKPALSEEERQEQTKR--------MLELVAQKQREREEREEREALERE- 121
GL+ A +GK +L ++ RQE+ +R + E Q++R++ + +ERE E E
Sbjct: 94 GLDEEKRARCDGKESLLQDRRQEEDQRRFEPRDRQLEEEPGQRRRQKRQEQERELAEGEE 153
Query: 122 ----------RQRRRQGQELSAARQRLQEDEMRRAAEER----RREKAEELAARQRVREK 167
R R+R+ +EL RQ QE E RRA EE+ + + EE +++R +
Sbjct: 154 QSEKQERLEQRDRQRRDEELWRQRQEWQEREERRAEEEQLQSCKGHETEEFPDEEQLRRR 213
Score = 49.7 bits (117), Expect = 3e-06
Identities = 28/97 (28%), Positives = 55/97 (56%), Gaps = 8/97 (8%)
Query: 86 LSEEERQ-----EQTKRMLELVAQKQREREEREEREAL---ERERQRRRQGQELSAARQR 137
L +EE Q +T+R EL Q ++E E ++E E L E E++RR++ + +
Sbjct: 1056 LQQEEEQLLGEERETRRRQELERQYRKEEELQQEEEQLLREEPEKRRRQERERQCREEEE 1115
Query: 138 LQEDEMRRAAEERRREKAEELAARQRVREKIERDKAE 174
LQ++E + EER + + +EL + R E++++++ +
Sbjct: 1116 LQQEEEQLLREEREKRRRQELERQYREEEEVQQEEEQ 1152
Score = 49.3 bits (116), Expect = 4e-06
Identities = 28/98 (28%), Positives = 55/98 (56%), Gaps = 9/98 (9%)
Query: 89 EERQEQTKRMLELVAQKQRERE--------EREEREALERERQRRRQGQELSAARQRLQE 140
EE+Q+Q + + V Q++ E+E +EE + E E QR+R+ QE ++L+
Sbjct: 224 EEKQQQRRERQDRVFQEEEEKEWRKRETVLRKEEEKLQEEEPQRQRELQEEEEQLRKLER 283
Query: 141 DEMRRAAEERRREKAEELAARQRVREKIERDKAERAKK 178
E+RR +E +++ + L Q++R K E ++ E+ ++
Sbjct: 284 QELRRERQEEEQQQ-QRLRREQQLRRKQEEERREQQEE 320
Score = 49.3 bits (116), Expect = 4e-06
Identities = 39/130 (30%), Positives = 60/130 (46%), Gaps = 11/130 (8%)
Query: 58 HILGREPTSSEQGGLEGSGSAAGEGKPALSEEER-----QEQTKRMLELVAQKQRE---- 108
H L +P EQ L E + L EER QEQ ++ E +Q E
Sbjct: 887 HTLYAKPALQEQ--LRKEQQLLQEEEEELQREEREKRRRQEQERQYREEEQLQQEEEQLL 944
Query: 109 REEREEREALERERQRRRQGQELSAARQRLQEDEMRRAAEERRREKAEELAARQRVREKI 168
REERE+R ERERQ R+ + Q L E+ +R +ER ++ EE +Q + +
Sbjct: 945 REEREKRRRQERERQYRKDKKLQQKEEQLLGEEPEKRRRQEREKKYREEEELQQEEEQLL 1004
Query: 169 ERDKAERAKK 178
++ +R ++
Sbjct: 1005 REEREKRRRQ 1014
Score = 49.3 bits (116), Expect = 4e-06
Identities = 46/157 (29%), Positives = 71/157 (45%), Gaps = 16/157 (10%)
Query: 39 LMEHEDDPDVDEPLETPLGHILGREPTSSEQGGLEGS----GSAAGEGKPALSEE----E 90
L E E +E L+ +LG E + + LE E + L EE
Sbjct: 1043 LQERERQYREEEELQQEEEQLLGEERETRRRQELERQYRKEEELQQEEEQLLREEPEKRR 1102
Query: 91 RQEQTKRMLELVAQKQRE----REEREEREALERERQRRRQGQELSAARQRLQEDEMRRA 146
RQE+ ++ E +Q E REERE+R E ERQ R + + Q L+E+ +R
Sbjct: 1103 RQERERQCREEEELQQEEEQLLREEREKRRRQELERQYREEEEVQQEEEQLLREEPEKRR 1162
Query: 147 AEERRREKAEELAARQR----VREKIERDKAERAKKY 179
+E R+ EE +Q +RE+ E+ + ER ++Y
Sbjct: 1163 RQELERQYREEEELQQEEEQLLREEQEKRRQERERQY 1199
Score = 48.9 bits (115), Expect = 6e-06
Identities = 33/95 (34%), Positives = 51/95 (53%), Gaps = 13/95 (13%)
Query: 88 EEERQEQTKRMLELVAQKQREREER----EEREALERERQRRRQGQELSAARQRLQEDEM 143
E ER EQ +R +L ++ ER ER EE E RE+Q RR+ +Q +E E
Sbjct: 463 ETERHEQERRKQQLKRDQEEERRERWLKLEEEE--RREQQERRE-------QQLRREQEE 513
Query: 144 RRAAEERRREKAEELAARQRVREKIERDKAERAKK 178
RR +R+E+ E L R R +++ R++ ER ++
Sbjct: 514 RREQRLKRQEEEERLQQRLRSEQQLRREQEERREQ 548
Score = 48.5 bits (114), Expect = 7e-06
Identities = 37/138 (26%), Positives = 62/138 (44%), Gaps = 18/138 (13%)
Query: 41 EHEDDPDVDEPLETPLGHILGREPTSSEQGGLEGSGSAAGEGKPALSEEERQEQTKRMLE 100
E E D+ L+ +LG EP + E K EEE Q++ +++L
Sbjct: 955 ERERQYRKDKKLQQKEEQLLGEEPEKRRRQERE---------KKYREEEELQQEEEQLL- 1004
Query: 101 LVAQKQREREEREEREALERERQRRRQGQELSAARQRLQEDEMRRAAEERRREKAEELAA 160
REERE+R E ERQ R++ + Q L+E+ +R +ER R+ EE
Sbjct: 1005 --------REEREKRRRQEWERQYRKKDELQQEEEQLLREEREKRRLQERERQYREEEEL 1056
Query: 161 RQRVREKIERDKAERAKK 178
+Q + + ++ R ++
Sbjct: 1057 QQEEEQLLGEERETRRRQ 1074
Score = 48.1 bits (113), Expect = 1e-05
Identities = 27/100 (27%), Positives = 54/100 (54%), Gaps = 9/100 (9%)
Query: 88 EEERQEQTKRMLELVAQKQREREEREEREALERERQRRRQGQELSAARQRL--------- 138
EE RQ++ KR E +++ +REE E E ER QR ++ + RQ+L
Sbjct: 583 EERRQQRLKREQEERLEQRLKREEVERLEQEERREQRLKREEPEEERRQQLLKSEEQEER 642
Query: 139 QEDEMRRAAEERRREKAEELAARQRVREKIERDKAERAKK 178
++ ++RR +ERR ++ + +R+ ++++R+ E ++
Sbjct: 643 RQQQLRREQQERREQRLKREEEEERLEQRLKREHEEERRE 682
Score = 48.1 bits (113), Expect = 1e-05
Identities = 32/93 (34%), Positives = 55/93 (59%), Gaps = 5/93 (5%)
Query: 86 LSEEERQEQTKRMLELVAQKQREREEREEREALERERQRRRQGQELSAARQRLQEDEMRR 145
L EER++ +R EL Q + E E ++E E L RE +R+ QEL RQ +E+E+++
Sbjct: 1123 LLREEREK--RRRQELERQYREEEEVQQEEEQLLREEPEKRRRQELE--RQYREEEELQQ 1178
Query: 146 AAEERRREKAEELAARQRVREKIERDKAERAKK 178
E+ RE+ +E ++R R+ E ++ +R K+
Sbjct: 1179 EEEQLLREE-QEKRRQERERQYREEEELQRQKR 1210
Score = 47.4 bits (111), Expect = 2e-05
Identities = 26/94 (27%), Positives = 59/94 (62%), Gaps = 6/94 (6%)
Query: 90 ERQEQTKRMLELVAQKQREREEREER--EALERERQRRRQGQELSAARQRLQE---DEMR 144
+RQE+ +R+ + + +Q+ R E+EER + L+RE ++R + + +R QE D++
Sbjct: 520 KRQEEEERLQQRLRSEQQLRREQEERREQLLKREEEKRLEQERREQRLKREQEERRDQLL 579
Query: 145 RAAEERRREKAEELAARQRVREKIERDKAERAKK 178
+ EERR+++ + +R+ ++++R++ ER ++
Sbjct: 580 KREEERRQQRLKR-EQEERLEQRLKREEVERLEQ 612
Score = 46.6 bits (109), Expect = 3e-05
Identities = 43/156 (27%), Positives = 74/156 (47%), Gaps = 20/156 (12%)
Query: 86 LSEEERQEQTKRMLELVAQKQRERE-EREEREALERERQRRRQGQELSAARQRLQEDEMR 144
L+EEE+++ +R+ + + Q + E E + R++ R R+++GQ R+R +++E R
Sbjct: 685 LAEEEQEQARERIKSRIPKWQWQLESEADARQSKVYSRPRKQEGQ-----RRRQEQEEKR 739
Query: 145 RAAEERRREKAEELAARQRVREKIERD-----KAERAKKYGGSVGSQPPPVAPEPGPVPS 199
R E + + EE A RQ+ E+ RD +AE + G S PP+ +
Sbjct: 740 RRRESELQWQEEERAHRQQQEEEQRRDFTWQWQAEEKSERGRQRLSARPPLREQ------ 793
Query: 200 SPSQEPPTKREYDQCRIQVRLPDGTSLTQTFRAREQ 235
+E + E Q R Q LP+ Q R R +
Sbjct: 794 ---RERQLRAEERQQREQRFLPEEEEKEQRRRQRRE 826
Score = 46.2 bits (108), Expect = 4e-05
Identities = 29/96 (30%), Positives = 50/96 (52%), Gaps = 1/96 (1%)
Query: 83 KPALSEEERQEQTKRMLELVAQKQREREEREEREALERERQRRRQGQELSAARQRLQEDE 142
K L E ERQ + + L+ ++Q EERE R E ERQ R++ + Q L+E+
Sbjct: 1040 KRRLQERERQYREEEELQQ-EEEQLLGEERETRRRQELERQYRKEEELQQEEEQLLREEP 1098
Query: 143 MRRAAEERRREKAEELAARQRVREKIERDKAERAKK 178
+R +ER R+ EE +Q + + ++ +R ++
Sbjct: 1099 EKRRRQERERQCREEEELQQEEEQLLREEREKRRRQ 1134
Score = 45.8 bits (107), Expect = 5e-05
Identities = 38/131 (29%), Positives = 63/131 (48%), Gaps = 18/131 (13%)
Query: 89 EERQEQTKRMLELVA-----QKQREREEREEREALERERQRRRQGQELSAARQRLQEDEM 143
+ER+EQ R + ++Q + EE+E+R ER+RQ R + Q + + R +E E+
Sbjct: 1805 QEREEQQLRPQQRDGKYRWEEEQLQLEEQEQRLRQERDRQYRAEEQFATQEKSRREEQEL 1864
Query: 144 RRAAEERRREKAEELAARQRVREKIERDKAERAKKYGGSVGSQPPP---VAPEPG----- 195
+ E++RR++ E + +R + K E+ + G + SQ EPG
Sbjct: 1865 WQEEEQKRRQERERKLREEHIR---RQQKEEQRHRQVGEIKSQEGKGHGRLLEPGTHQFA 1921
Query: 196 --PVPSSPSQE 204
PV SSP E
Sbjct: 1922 SVPVRSSPLYE 1932
Score = 44.7 bits (104), Expect = 1e-04
Identities = 29/92 (31%), Positives = 50/92 (54%), Gaps = 3/92 (3%)
Query: 86 LSEEERQEQTKRMLELVAQKQREREEREEREALERERQRRRQGQELSAARQRLQEDEMRR 145
L +EER+EQ + E +++++ + EE+E R++Q RR+ QE QRL+ +E
Sbjct: 610 LEQEERREQRLKREEPEEERRQQLLKSEEQEE-RRQQQLRREQQE--RREQRLKREEEEE 666
Query: 146 AAEERRREKAEELAARQRVREKIERDKAERAK 177
E+R + + EE Q + E+ + ER K
Sbjct: 667 RLEQRLKREHEEERREQELAEEEQEQARERIK 698
Score = 44.3 bits (103), Expect = 1e-04
Identities = 35/111 (31%), Positives = 62/111 (55%), Gaps = 15/111 (13%)
Query: 83 KPALSEEE----RQEQTKRMLELVAQKQREREE--REEREAL--ERERQRRRQGQELSAA 134
K L +EE R+E+ KR L+ ++ RE EE +EE + L ERE +RR++ +
Sbjct: 1023 KDELQQEEEQLLREEREKRRLQERERQYREEEELQQEEEQLLGEERETRRRQELERQYRK 1082
Query: 135 RQRLQEDE---MRRAAEERRREKAE----ELAARQRVREKIERDKAERAKK 178
+ LQ++E +R E+RRR++ E E Q+ E++ R++ E+ ++
Sbjct: 1083 EEELQQEEEQLLREEPEKRRRQERERQCREEEELQQEEEQLLREEREKRRR 1133
Score = 43.9 bits (102), Expect = 2e-04
Identities = 32/96 (33%), Positives = 49/96 (51%), Gaps = 9/96 (9%)
Query: 88 EEERQEQTKRMLELVAQKQREREEREEREALERERQRRRQGQELSAARQRLQEDEMRR-- 145
EEER EQ + +RE+EER R+ L+RE + R QE + + ++E RR
Sbjct: 430 EEERHEQKHEQERREQRLKREQEER--RDWLKREEETERHEQERRKQQLKRDQEEERRER 487
Query: 146 ---AAEERRREKAEELAARQRVREKIERDKAERAKK 178
EE RRE+ E Q++R + E + +R K+
Sbjct: 488 WLKLEEEERREQQER--REQQLRREQEERREQRLKR 521
Score = 43.9 bits (102), Expect = 2e-04
Identities = 26/105 (24%), Positives = 56/105 (53%), Gaps = 7/105 (6%)
Query: 81 EGKPALSEEERQEQTKRMLELVAQKQREREEREEREALERERQRRRQGQELSAARQRLQE 140
E + L +E R+++ KR E + +REE ++ L+RE++ R + + +RL++
Sbjct: 553 EEEKRLEQERREQRLKREQEERRDQLLKREEERRQQRLKREQEERLEQRLKREEVERLEQ 612
Query: 141 DEMR-------RAAEERRREKAEELAARQRVREKIERDKAERAKK 178
+E R EERR++ + +R ++++ R++ ER ++
Sbjct: 613 EERREQRLKREEPEEERRQQLLKSEEQEERRQQQLRREQQERREQ 657
Score = 43.9 bits (102), Expect = 2e-04
Identities = 45/184 (24%), Positives = 81/184 (44%), Gaps = 20/184 (10%)
Query: 86 LSEEERQEQTKRMLELVAQKQREREEREEREALERERQRRRQGQELSAARQ--------- 136
L EE++E +R + +KQ REEREE+ + ++ R+ ++L R+
Sbjct: 1299 LEREEQKEAKRRDRKSQEEKQLLREEREEKRRRQETDRKFREEEQLLQEREEQPLRRQER 1358
Query: 137 --RLQEDEMRRAAEERR-REKAEELAARQRVREKIERDKAERAKKYGGSVGSQPPPVAPE 193
+ +E+E+R + R+ E+ + L ++R R+ ++ ++ R ++ + E
Sbjct: 1359 DRKFREEELRHQEQGRKFLEEEQRLRRQERERKFLKEEQQLRCQEREQQLRQDRDRKFRE 1418
Query: 194 PGPVPSSPSQEPPTKREYDQCRIQVR----LPDGTSLTQ----TFRAREQLAAVRLYVEL 245
S ++ + E Q R Q R L + L Q FR EQL R +L
Sbjct: 1419 EEQQLSRQERDRKFREEEQQVRRQERERKFLEEEQQLRQERHRKFREEEQLLQEREEQQL 1478
Query: 246 HRGE 249
HR E
Sbjct: 1479 HRQE 1482
Score = 43.9 bits (102), Expect = 2e-04
Identities = 26/103 (25%), Positives = 55/103 (53%), Gaps = 7/103 (6%)
Query: 81 EGKPALSEEERQEQTKRMLELVAQKQRERE----EREEREALERERQRRRQGQELSAARQ 136
E +P L +ER++Q + + +K RE E E EE++ +ER R+ + +E RQ
Sbjct: 1647 EEEPQLRRQEREQQLRHDRD---RKFREEEQLLQEGEEQQLRRQERDRKFREEEQQLRRQ 1703
Query: 137 RLQEDEMRRAAEERRREKAEELAARQRVREKIERDKAERAKKY 179
+ ++ + RR+E + +++R++ E+++ R ++Y
Sbjct: 1704 ERERKFLQEEQQLRRQELERKFREEEQLRQETEQEQLRRQERY 1746
Score = 43.5 bits (101), Expect = 2e-04
Identities = 30/102 (29%), Positives = 55/102 (53%), Gaps = 14/102 (13%)
Query: 91 RQEQTKRMLELVAQKQREREEREERE-------ALERERQRRRQGQE---LSAARQRLQE 140
R++Q +R +L ++Q RE++ RE L RE+Q RR+ +E Q +E
Sbjct: 385 REQQLRREQQLRREQQLRREQQLRREQQLRREQQLRREQQLRREQEEERHEQKHEQERRE 444
Query: 141 DEMRRAAEERR----REKAEELAARQRVREKIERDKAERAKK 178
++R EERR RE+ E ++R +++++RD+ E ++
Sbjct: 445 QRLKREQEERRDWLKREEETERHEQERRKQQLKRDQEEERRE 486
Score = 43.5 bits (101), Expect = 2e-04
Identities = 32/96 (33%), Positives = 56/96 (58%), Gaps = 7/96 (7%)
Query: 88 EEERQEQTKRMLELVAQKQR-EREEREER--EALERERQRRRQGQELSAARQRLQEDEMR 144
++ER+EQ R + ++QR +R+E EER + L E+Q RR+ +E Q L+ +E +
Sbjct: 499 QQERREQQLRREQEERREQRLKRQEEEERLQQRLRSEQQLRREQEE--RREQLLKREEEK 556
Query: 145 RAAEERR--REKAEELAARQRVREKIERDKAERAKK 178
R +ERR R K E+ R ++ ++ E + +R K+
Sbjct: 557 RLEQERREQRLKREQEERRDQLLKREEERRQQRLKR 592
Score = 43.5 bits (101), Expect = 2e-04
Identities = 29/102 (28%), Positives = 57/102 (55%), Gaps = 7/102 (6%)
Query: 81 EGKPALSEEERQEQTKRMLELVAQKQR-EREEREE---REALERERQRRRQGQELSAARQ 136
E + L + ++E+ +R+ + ++QR +REE EE ++ L+ E Q R+ Q+L +Q
Sbjct: 593 EQEERLEQRLKREEVERLEQEERREQRLKREEPEEERRQQLLKSEEQEERRQQQLRREQQ 652
Query: 137 RLQEDEMRRAAEERRREKAEELAARQRVREKIERDKAERAKK 178
+E ++R EE E+ E+ R+ E+ E++ AE ++
Sbjct: 653 ERREQRLKREEEE---ERLEQRLKREHEEERREQELAEEEQE 691
Score = 43.1 bits (100), Expect = 3e-04
Identities = 26/89 (29%), Positives = 50/89 (56%), Gaps = 10/89 (11%)
Query: 88 EEERQEQTKRMLELVAQKQREREEREEREALERERQRRRQGQELSAARQRLQEDEMRRAA 147
EEE Q++ +++L RE E+ R+ LER+ R+ +EL ++L +E +
Sbjct: 1143 EEEVQQEEEQLL-------REEPEKRRRQELERQ---YREEEELQQEEEQLLREEQEKRR 1192
Query: 148 EERRREKAEELAARQRVREKIERDKAERA 176
+ER R+ EE +++ R++ RD+ +R+
Sbjct: 1193 QERERQYREEEELQRQKRKQRYRDEDQRS 1221
Score = 42.7 bits (99), Expect = 4e-04
Identities = 40/147 (27%), Positives = 68/147 (46%), Gaps = 18/147 (12%)
Query: 43 EDDPDVDEPLETPLGHILGREPTSSEQGGLEGSGSAAGEGKPALSEEERQEQTKRMLELV 102
ED D + L H+LG E ++ P + ER+EQ +
Sbjct: 1254 EDSQLRDRQSQQDLQHLLG-EQQERDREQERRRWQQRDRHFPEEEQLEREEQKEA----- 1307
Query: 103 AQKQREREEREEREALERERQRRRQGQE----LSAARQRLQEDEMR--RAAEERRREKAE 156
K+R+R+ +EE++ L ER+ +R+ QE Q LQE E + R E R+ + E
Sbjct: 1308 --KRRDRKSQEEKQLLREEREEKRRRQETDRKFREEEQLLQEREEQPLRRQERDRKFREE 1365
Query: 157 ELAARQRVREKIERD----KAERAKKY 179
EL +++ R+ +E + + ER +K+
Sbjct: 1366 ELRHQEQGRKFLEEEQRLRRQERERKF 1392
Score = 42.4 bits (98), Expect = 5e-04
Identities = 28/109 (25%), Positives = 55/109 (50%), Gaps = 20/109 (18%)
Query: 86 LSEEERQEQTKRMLELVAQKQREREEREEREA------------LERERQRRRQG----- 128
L EEE+ ++ +R +L ++ +E++E R + LE ER+RRR
Sbjct: 834 LEEEEQLQRRERAQQLQEEEDGLQEDQERRRSQEQRRDQKWRWQLEEERKRRRHTLYAKP 893
Query: 129 ---QELSAARQRLQEDEMRRAAEERRREKAEELAARQRVREKIERDKAE 174
++L +Q LQE+E EER + + +E + R E++++++ +
Sbjct: 894 ALQEQLRKEQQLLQEEEEELQREEREKRRRQEQERQYREEEQLQQEEEQ 942
Score = 41.6 bits (96), Expect = 0.001
Identities = 27/103 (26%), Positives = 54/103 (52%), Gaps = 15/103 (14%)
Query: 91 RQEQTKRMLELVAQKQREREEREER-----------EALERERQRRR----QGQELSAAR 135
R++Q +R +L ++Q RE+ EER + L+RE++ RR + +E
Sbjct: 409 REQQLRREQQLRREQQLRREQEEERHEQKHEQERREQRLKREQEERRDWLKREEETERHE 468
Query: 136 QRLQEDEMRRAAEERRREKAEELAARQRVREKIERDKAERAKK 178
Q ++ +++R EE RRE+ +L +R ++ R++ R ++
Sbjct: 469 QERRKQQLKRDQEEERRERWLKLEEEERREQQERREQQLRREQ 511
Score = 41.6 bits (96), Expect = 0.001
Identities = 25/88 (28%), Positives = 52/88 (59%), Gaps = 3/88 (3%)
Query: 91 RQEQTKRMLELVAQKQREREER-EEREALERERQRRRQGQELSAARQRLQEDEMRRAAEE 149
++EQ R E Q++++R+ + E E L +ER+ ++ ++ + RL+E ++RR +E
Sbjct: 1535 QEEQQLRRQERGQQRRQDRDRKFREEEQLRQEREEQQLSRQERDRKFRLEEQKVRRQEQE 1594
Query: 150 RRREKAEELAARQRVREKI--ERDKAER 175
R+ + E+ RQ ++++ ERD+ R
Sbjct: 1595 RKFMEDEQQLRRQEGQQQLRQERDRKFR 1622
Score = 41.2 bits (95), Expect = 0.001
Identities = 29/114 (25%), Positives = 56/114 (49%), Gaps = 19/114 (16%)
Query: 81 EGKPALSEEERQEQTKRMLELVAQKQ--------------REREEREEREALER-ERQRR 125
+G+ L EE+R + +R + + ++Q R+R+ REE + L R ER R+
Sbjct: 1372 QGRKFLEEEQRLRRQERERKFLKEEQQLRCQEREQQLRQDRDRKFREEEQQLSRQERDRK 1431
Query: 126 RQGQELSAARQ----RLQEDEMRRAAEERRREKAEELAARQRVREKIERDKAER 175
+ +E RQ + E+E + E R+ + EE ++R +++ R + +R
Sbjct: 1432 FREEEQQVRRQERERKFLEEEQQLRQERHRKFREEEQLLQEREEQQLHRQERDR 1485
Score = 40.8 bits (94), Expect = 0.002
Identities = 27/109 (24%), Positives = 52/109 (47%), Gaps = 13/109 (11%)
Query: 83 KPALSEEE--RQEQTKRMLELVAQKQREREEREEREALERERQR-----------RRQGQ 129
+P E + RQEQ ++ ++ Q + EER R+ E E++R +G+
Sbjct: 722 RPRKQEGQRRRQEQEEKRRRRESELQWQEEERAHRQQQEEEQRRDFTWQWQAEEKSERGR 781
Query: 130 ELSAARQRLQEDEMRRAAEERRREKAEELAARQRVREKIERDKAERAKK 178
+ +AR L+E R+ E R+++ + + +E+ R + ER K+
Sbjct: 782 QRLSARPPLREQRERQLRAEERQQREQRFLPEEEEKEQRRRQRREREKE 830
Score = 40.8 bits (94), Expect = 0.002
Identities = 30/106 (28%), Positives = 56/106 (52%), Gaps = 16/106 (15%)
Query: 91 RQEQTKRMLELVAQKQRER-----------EEREEREALERERQRRRQGQELSAARQ--- 136
RQE+ ++ LE Q ++ER +EREE++ +ER R+ +E RQ
Sbjct: 1441 RQERERKFLEEEQQLRQERHRKFREEEQLLQEREEQQLHRQERDRKFLEEEQQLRRQERD 1500
Query: 137 -RLQEDEMRRAAEERR-REKAEELAARQRVREKIERDKAERAKKYG 180
+ +E E+R ER+ E+ ++L +QR R+ ++ ++ R ++ G
Sbjct: 1501 RKFREQELRSQEPERKFLEEEQQLHRQQRQRKFLQEEQQLRRQERG 1546
Score = 40.8 bits (94), Expect = 0.002
Identities = 29/97 (29%), Positives = 54/97 (55%), Gaps = 8/97 (8%)
Query: 88 EEERQEQTKRMLELVAQKQREREEREEREALERERQRRRQG-----QELSAARQRLQEDE 142
EE++ + +R + ++Q+ R + ER+ L+ E+Q RRQ +E RQ ++++
Sbjct: 1680 EEQQLRRQERDRKFREEEQQLRRQERERKFLQEEQQLRRQELERKFREEEQLRQETEQEQ 1739
Query: 143 MRRAAEERRREKAEELAARQRVREKIERDKAERAKKY 179
+RR +ER R+ EE R RE+ + + ER +K+
Sbjct: 1740 LRR--QERYRKILEEEQLRPE-REEQQLRRQERDRKF 1773
Score = 40.4 bits (93), Expect = 0.002
Identities = 24/101 (23%), Positives = 55/101 (54%), Gaps = 14/101 (13%)
Query: 88 EEERQEQTKRMLELVAQKQREREERE------------EREAL--ERERQRRRQGQELSA 133
EEE+ +Q + L +++R R+ERE E + L E E++RR++ ++
Sbjct: 932 EEEQLQQEEEQLLREEREKRRRQERERQYRKDKKLQQKEEQLLGEEPEKRRRQEREKKYR 991
Query: 134 ARQRLQEDEMRRAAEERRREKAEELAARQRVREKIERDKAE 174
+ LQ++E + EER + + +E + R ++++++++ +
Sbjct: 992 EEEELQQEEEQLLREEREKRRRQEWERQYRKKDELQQEEEQ 1032
Score = 40.0 bits (92), Expect = 0.003
Identities = 30/116 (25%), Positives = 62/116 (53%), Gaps = 17/116 (14%)
Query: 81 EGKPALSEEERQEQTKRMLELVAQKQREREEREEREALERERQRR-RQGQELSAARQRLQ 139
E + LS +ER + + + V +++RER+ EE + L +ER R+ R+ ++L R+ Q
Sbjct: 1418 EEEQQLSRQERDRKFREEEQQVRRQERERKFLEEEQQLRQERHRKFREEEQLLQEREEQQ 1477
Query: 140 -----------EDEMRRAAEER-RREKAEELAARQRVREKIERD----KAERAKKY 179
E+E + +ER R+ + +EL +++ R+ +E + + +R +K+
Sbjct: 1478 LHRQERDRKFLEEEQQLRRQERDRKFREQELRSQEPERKFLEEEQQLHRQQRQRKF 1533
Score = 40.0 bits (92), Expect = 0.003
Identities = 28/86 (32%), Positives = 43/86 (50%), Gaps = 3/86 (3%)
Query: 89 EERQEQTKRMLELVAQKQREREEREEREALERERQRRRQGQELSAARQRLQEDEMRRAAE 148
+ER+EQ R E + + E + R+ERE + Q+R + +L+E E R E
Sbjct: 1781 QEREEQQLRSQESDRKFREEEQLRQEREEQQLRPQQRDGKYRWEEEQLQLEEQEQRLRQE 1840
Query: 149 ERRREKAEELAARQRVREKIERDKAE 174
R+ +AEE A Q EK R++ E
Sbjct: 1841 RDRQYRAEEQFATQ---EKSRREEQE 1863
Score = 39.7 bits (91), Expect = 0.003
Identities = 41/178 (23%), Positives = 78/178 (43%), Gaps = 36/178 (20%)
Query: 91 RQEQTKRMLELVAQKQREREERE-----------EREALERERQRRRQGQELSAARQRLQ 139
RQE+ ++ LE Q +R+ +R+ ER+ LE E+Q RQ ++ R+ LQ
Sbjct: 1480 RQERDRKFLEEEQQLRRQERDRKFREQELRSQEPERKFLEEEQQLHRQQRQ----RKFLQ 1535
Query: 140 EDEMRRAAE---ERRREKAEELAARQRVREKIERDKAERAKKYGGSVGSQPPPVAPEPGP 196
E++ R E +RR+++ + +++R++ E + R ++
Sbjct: 1536 EEQQLRRQERGQQRRQDRDRKFREEEQLRQEREEQQLSRQER-------------DRKFR 1582
Query: 197 VPSSPSQEPPTKREYDQCRIQVRLPDG-----TSLTQTFRAREQLAAVRLYVELHRGE 249
+ + +R++ + Q+R +G + FR EQL R +LHR E
Sbjct: 1583 LEEQKVRRQEQERKFMEDEQQLRRQEGQQQLRQERDRKFREDEQLLQEREEQQLHRQE 1640
Score = 39.7 bits (91), Expect = 0.003
Identities = 29/101 (28%), Positives = 60/101 (59%), Gaps = 9/101 (8%)
Query: 81 EGKPALSEEERQE--QTKRMLELVAQKQREREEREEREALERERQRRRQGQELSAARQRL 138
EG+ L +E ++ + +++L+ ++Q R+ER +R+ LE E Q RRQ +E Q+L
Sbjct: 1608 EGQQQLRQERDRKFREDEQLLQEREEQQLHRQER-DRKFLEEEPQLRRQERE-----QQL 1661
Query: 139 QEDEMRRAAEERR-REKAEELAARQRVREKIERDKAERAKK 178
+ D R+ EE + ++ EE R++ R++ R++ ++ ++
Sbjct: 1662 RHDRDRKFREEEQLLQEGEEQQLRRQERDRKFREEEQQLRR 1702
Score = 39.3 bits (90), Expect = 0.005
Identities = 26/87 (29%), Positives = 45/87 (51%), Gaps = 4/87 (4%)
Query: 89 EERQEQTKRMLELVAQKQREREEREEREALERERQRRRQGQELSAARQRLQEDEMRRAAE 148
EE Q + +R + + +QR+ + R E E L+ E Q +R QE R R E + A +
Sbjct: 1799 EEEQLRQEREEQQLRPQQRDGKYRWEEEQLQLEEQEQRLRQE----RDRQYRAEEQFATQ 1854
Query: 149 ERRREKAEELAARQRVREKIERDKAER 175
E+ R + +EL + + + ER++ R
Sbjct: 1855 EKSRREEQELWQEEEQKRRQERERKLR 1881
Score = 38.9 bits (89), Expect = 0.006
Identities = 29/88 (32%), Positives = 53/88 (60%), Gaps = 15/88 (17%)
Query: 88 EEERQEQTKRMLELVAQKQRE-REEREEREALERERQRRRQGQELSAARQRLQEDEMRRA 146
EEER++Q + E ++Q++ R E++ER RE++ +R+ +E +RL E ++R
Sbjct: 626 EEERRQQLLKSEEQEERRQQQLRREQQER----REQRLKREEEE-----ERL-EQRLKRE 675
Query: 147 AEERRRE----KAEELAARQRVREKIER 170
EE RRE + E+ AR+R++ +I +
Sbjct: 676 HEEERREQELAEEEQEQARERIKSRIPK 703
Score = 38.9 bits (89), Expect = 0.006
Identities = 32/102 (31%), Positives = 57/102 (55%), Gaps = 17/102 (16%)
Query: 89 EERQEQTKRMLEL--VAQKQRER----EEREEREAL-----ERERQRRRQGQELSAARQR 137
EE+ E+ ++ L ++QRER EER++RE E + QRRRQ +E Q
Sbjct: 774 EEKSERGRQRLSARPPLREQRERQLRAEERQQREQRFLPEEEEKEQRRRQRREREKELQF 833
Query: 138 LQEDEMRRAAEERRREKAEELAARQ-RVREKIERDKAERAKK 178
L+E+E + +RRE+A++L + ++E ER +++ ++
Sbjct: 834 LEEEE-----QLQRRERAQQLQEEEDGLQEDQERRRSQEQRR 870
Score = 38.9 bits (89), Expect = 0.006
Identities = 31/110 (28%), Positives = 53/110 (48%), Gaps = 15/110 (13%)
Query: 81 EGKPALSEEE-----RQEQTKRMLELVAQ---KQREREEREERE-ALERERQRRRQGQEL 131
E + L E E RQE+ ++ LE Q ++RE++ R +R+ E Q ++G+E
Sbjct: 1623 EDEQLLQEREEQQLHRQERDRKFLEEEPQLRRQEREQQLRHDRDRKFREEEQLLQEGEEQ 1682
Query: 132 SAARQ------RLQEDEMRRAAEERRREKAEELAARQRVREKIERDKAER 175
RQ R +E ++RR ER+ + E+ RQ + K ++ R
Sbjct: 1683 QLRRQERDRKFREEEQQLRRQERERKFLQEEQQLRRQELERKFREEEQLR 1732
Score = 38.5 bits (88), Expect = 0.008
Identities = 34/149 (22%), Positives = 65/149 (43%), Gaps = 27/149 (18%)
Query: 55 PLGHILGREPTSSEQGGLEGSGSAAGEGKPALSEEERQEQTKRML--ELVAQKQREREER 112
P L EP + + EG+ ++ER EQ R E + ++++E +ER
Sbjct: 124 PRDRQLEEEPGQRRRQKRQEQERELAEGEEQSEKQERLEQRDRQRRDEELWRQRQEWQER 183
Query: 113 EEREALERERQR-----------------------RRQGQELSAARQRLQEDEMRRAAEE 149
EER A E + Q RR+G+E ++R ++D + + EE
Sbjct: 184 EERRAEEEQLQSCKGHETEEFPDEEQLRRRELLELRRKGREEKQQQRRERQDRVFQEEEE 243
Query: 150 RRREKAEELAARQRVREKIERDKAERAKK 178
+ K E + ++ EK++ ++ +R ++
Sbjct: 244 KEWRKRETVLRKE--EEKLQEEEPQRQRE 270
Score = 38.5 bits (88), Expect = 0.008
Identities = 23/91 (25%), Positives = 45/91 (49%), Gaps = 2/91 (2%)
Query: 88 EEERQEQTKRMLELVAQKQREREEREEREALERERQRRRQGQELSAARQRLQEDEMRRAA 147
EEE++ + + +R R+ R L +R+R+ + +E QR +E +
Sbjct: 760 EEEQRRDFTWQWQAEEKSERGRQRLSARPPLREQRERQLRAEERQQREQRFLPEEEEK-- 817
Query: 148 EERRREKAEELAARQRVREKIERDKAERAKK 178
E+RRR++ E Q + E+ + + ERA++
Sbjct: 818 EQRRRQRREREKELQFLEEEEQLQRRERAQQ 848
Score = 38.1 bits (87), Expect = 0.010
Identities = 29/95 (30%), Positives = 50/95 (52%), Gaps = 10/95 (10%)
Query: 88 EEERQEQTKRML----ELVAQKQREREEREEREALERERQRRRQGQELSAARQRLQEDEM 143
E ERQ + K L E + +++RE+ +ERE RE + +Q +E +R +
Sbjct: 1015 EWERQYRKKDELQQEEEQLLREEREKRRLQERERQYREEEELQQEEEQLLGEER---ETR 1071
Query: 144 RRAAEERRREKAEELAARQRVREKIERDKAERAKK 178
RR ER+ K EEL Q+ E++ R++ E+ ++
Sbjct: 1072 RRQELERQYRKEEEL---QQEEEQLLREEPEKRRR 1103
Score = 38.1 bits (87), Expect = 0.010
Identities = 28/102 (27%), Positives = 54/102 (52%), Gaps = 10/102 (9%)
Query: 88 EEERQEQTKRMLELVAQKQREREEREEREALERERQRRRQ--GQELSAARQR-------- 137
EE++ + +R + ++Q+ R + +ER+ +E E+Q RRQ Q+L R R
Sbjct: 1568 EEQQLSRQERDRKFRLEEQKVRRQEQERKFMEDEQQLRRQEGQQQLRQERDRKFREDEQL 1627
Query: 138 LQEDEMRRAAEERRREKAEELAARQRVREKIERDKAERAKKY 179
LQE E ++ + R K E + R +E+ ++ + +R +K+
Sbjct: 1628 LQEREEQQLHRQERDRKFLEEEPQLRRQEREQQLRHDRDRKF 1669
Score = 37.7 bits (86), Expect = 0.013
Identities = 25/100 (25%), Positives = 54/100 (54%), Gaps = 8/100 (8%)
Query: 86 LSEEERQEQTKRMLELVAQKQREREEREEREALERERQRRRQGQELSAARQ---RLQEDE 142
L EER+++ ++ E +K ++ +++EE+ E +RRRQ +E + + +E++
Sbjct: 943 LLREEREKRRRQERERQYRKDKKLQQKEEQLLGEEPEKRRRQEREKKYREEEELQQEEEQ 1002
Query: 143 MRRAAEERRREKAEELAAR-----QRVREKIERDKAERAK 177
+ R E+RR + E R Q+ E++ R++ E+ +
Sbjct: 1003 LLREEREKRRRQEWERQYRKKDELQQEEEQLLREEREKRR 1042
Score = 37.7 bits (86), Expect = 0.013
Identities = 19/87 (21%), Positives = 51/87 (58%), Gaps = 2/87 (2%)
Query: 89 EERQEQTKRMLELVAQKQREREEREEREALERERQRRRQGQELSAARQRLQEDEMRRAAE 148
EE Q + +R + +++++R+R+ R E + + R+ Q R+ ++ R++ + ++R+ +
Sbjct: 1559 EEEQLRQEREEQQLSRQERDRKFRLEEQKVRRQEQERKFMEDEQQLRRQEGQQQLRQERD 1618
Query: 149 ERRREKAEELAARQRVREKIERDKAER 175
+ RE +E ++R +++ R + +R
Sbjct: 1619 RKFRE--DEQLLQEREEQQLHRQERDR 1643
Score = 37.4 bits (85), Expect = 0.017
Identities = 28/80 (35%), Positives = 46/80 (57%), Gaps = 7/80 (8%)
Query: 91 RQEQTKRMLELVAQKQREREE----REEREALERERQRRRQGQELSAARQRLQEDEMRRA 146
RQE+ +++LE Q + EREE R+ER+ RE ++ RQ +E + R QE + +
Sbjct: 1742 RQERYRKILE-EEQLRPEREEQQLRRQERDRKFREEEQLRQERE--EQQLRSQESDRKFR 1798
Query: 147 AEERRREKAEELAARQRVRE 166
EE+ R++ EE R + R+
Sbjct: 1799 EEEQLRQEREEQQLRPQQRD 1818
Score = 37.0 bits (84), Expect = 0.023
Identities = 27/87 (31%), Positives = 48/87 (55%), Gaps = 6/87 (6%)
Query: 91 RQEQTKRMLELVAQKQREREEREEREALERERQRRRQGQELSAARQR--LQEDEMRRAAE 148
RQE+ ++ L+ Q +R+ ER+ RE E+ RQ Q Q R R L+E+++R E
Sbjct: 1702 RQERERKFLQEEQQLRRQELERKFREE-EQLRQETEQEQLRRQERYRKILEEEQLRPERE 1760
Query: 149 E---RRREKAEELAARQRVREKIERDK 172
E RR+E+ + +++R++ E +
Sbjct: 1761 EQQLRRQERDRKFREEEQLRQEREEQQ 1787
Score = 36.6 bits (83), Expect = 0.029
Identities = 29/94 (30%), Positives = 53/94 (56%), Gaps = 7/94 (7%)
Query: 90 ERQEQTKRMLEL---VAQKQREREEREEREALERERQRR-RQGQELSAARQRLQEDEMRR 145
ER+EQ R E ++++ R+EREE++ +E R+ R+ ++L R+ Q +R
Sbjct: 1758 EREEQQLRRQERDRKFREEEQLRQEREEQQLRSQESDRKFREEEQLRQEREEQQLRPQQR 1817
Query: 146 AAEERRREKAEELAAR-QRVREKIERDKAERAKK 178
+ R E+ +L + QR+R+ ERD+ RA++
Sbjct: 1818 DGKYRWEEEQLQLEEQEQRLRQ--ERDRQYRAEE 1849
Score = 35.0 bits (79), Expect = 0.086
Identities = 25/103 (24%), Positives = 55/103 (53%), Gaps = 7/103 (6%)
Query: 81 EGKPALSEEERQEQTKRMLELVAQKQREREEREEREALERERQRRRQGQELSAARQRLQE 140
E +P +E ++ + L Q ++ EE + ERER+ ++ Q+L R + +E
Sbjct: 1349 EEQPLRRQERDRKFREEELRHQEQGRKFLEEEQRLRRQERERKFLKEEQQL---RCQERE 1405
Query: 141 DEMRRAAEERRREKAEELAARQRVREKIERD----KAERAKKY 179
++R+ + + RE+ ++L+ ++R R+ E + + ER +K+
Sbjct: 1406 QQLRQDRDRKFREEEQQLSRQERDRKFREEEQQVRRQERERKF 1448
Score = 35.0 bits (79), Expect = 0.086
Identities = 21/94 (22%), Positives = 50/94 (53%), Gaps = 3/94 (3%)
Query: 89 EERQEQTKRMLELVAQKQREREEREEREAL---ERERQRRRQGQELSAARQRLQEDEMRR 145
++R + + + +++++R+R+ REE + + ERER+ + Q+L R R +E +
Sbjct: 1410 QDRDRKFREEEQQLSRQERDRKFREEEQQVRRQERERKFLEEEQQLRQERHRKFREEEQL 1469
Query: 146 AAEERRREKAEELAARQRVREKIERDKAERAKKY 179
E ++ + R+ + E+ + + ER +K+
Sbjct: 1470 LQEREEQQLHRQERDRKFLEEEQQLRRQERDRKF 1503
Score = 34.3 bits (77), Expect = 0.15
Identities = 19/88 (21%), Positives = 49/88 (55%), Gaps = 3/88 (3%)
Query: 88 EEERQEQTKRMLELVAQKQREREEREEREALERERQRRRQGQELSAARQRLQEDEMRRAA 147
+EE+Q + + + ++++ R+E E+ + +ER R+ +E R +E ++RR
Sbjct: 1711 QEEQQLRRQELERKFREEEQLRQETEQEQLRRQERYRKILEEE--QLRPEREEQQLRRQE 1768
Query: 148 EERRREKAEELAARQRVREKIERDKAER 175
+R+ + E+L ++R +++ +++R
Sbjct: 1769 RDRKFREEEQL-RQEREEQQLRSQESDR 1795
Score = 33.9 bits (76), Expect = 0.19
Identities = 23/89 (25%), Positives = 48/89 (53%), Gaps = 6/89 (6%)
Query: 88 EEERQEQTKRMLELVAQKQREREEREEREALERERQR-RRQGQELSAARQRLQEDEMRRA 146
EEE+ Q +L Q++ + EE+ ERE Q+ RRQ ++ ++ +E+E R
Sbjct: 1727 EEEQLRQETEQEQLRRQERYRKILEEEQLRPEREEQQLRRQERD-----RKFREEEQLRQ 1781
Query: 147 AEERRREKAEELAARQRVREKIERDKAER 175
E ++ +++E + R E++ +++ E+
Sbjct: 1782 EREEQQLRSQESDRKFREEEQLRQEREEQ 1810
Score = 33.5 bits (75), Expect = 0.25
Identities = 21/91 (23%), Positives = 44/91 (48%), Gaps = 9/91 (9%)
Query: 94 QTKRMLELVAQKQREREEREEREALERERQRRRQGQELSAARQR---------LQEDEMR 144
+ ++ +L + R+R+ +++ + L E+Q R + QE +QR L+ +E +
Sbjct: 1246 ENEQFRQLEDSQLRDRQSQQDLQHLLGEQQERDREQERRRWQQRDRHFPEEEQLEREEQK 1305
Query: 145 RAAEERRREKAEELAARQRVREKIERDKAER 175
A R+ + E+ R+ EK R + +R
Sbjct: 1306 EAKRRDRKSQEEKQLLREEREEKRRRQETDR 1336
Score = 33.5 bits (75), Expect = 0.25
Identities = 23/94 (24%), Positives = 52/94 (55%), Gaps = 4/94 (4%)
Query: 89 EERQEQTKRMLELVAQKQREREEREEREAL---ERERQRRRQGQELSAARQRLQEDEMRR 145
EE Q +R + + +++R+R+ EE + L ER+R+ R Q ++ E+E +
Sbjct: 1465 EEEQLLQEREEQQLHRQERDRKFLEEEQQLRRQERDRKFREQELRSQEPERKFLEEEQQL 1524
Query: 146 AAEERRREKAEELAARQRVREKIERDKAERAKKY 179
++R+R+ +E + R +E+ ++ + +R +K+
Sbjct: 1525 HRQQRQRKFLQE-EQQLRRQERGQQRRQDRDRKF 1557
Score = 33.5 bits (75), Expect = 0.25
Identities = 23/95 (24%), Positives = 47/95 (49%), Gaps = 4/95 (4%)
Query: 81 EGKPALSEEERQEQTKRMLELVAQKQREREEREEREALERERQRRRQGQELSAARQRLQE 140
E + L E E Q+ ++ + ++ ++ R+ER+ RE++ R Q E R+ L+E
Sbjct: 1465 EEEQLLQEREEQQLHRQERDRKFLEEEQQLRRQERDRKFREQELRSQEPE----RKFLEE 1520
Query: 141 DEMRRAAEERRREKAEELAARQRVREKIERDKAER 175
++ + +R+ EE R++ R + R +R
Sbjct: 1521 EQQLHRQQRQRKFLQEEQQLRRQERGQQRRQDRDR 1555
Score = 32.7 bits (73), Expect = 0.42
Identities = 22/78 (28%), Positives = 40/78 (51%), Gaps = 4/78 (5%)
Query: 88 EEERQEQTKRMLELVAQKQRERE----EREEREALERERQRRRQGQELSAARQRLQEDEM 143
E+ R+++ +R + Q+E E E +E+ ERERQ R + + R++ DE
Sbjct: 1159 EKRRRQELERQYREEEELQQEEEQLLREEQEKRRQERERQYREEEELQRQKRKQRYRDED 1218
Query: 144 RRAAEERRREKAEELAAR 161
+R+ + + E +E A R
Sbjct: 1219 QRSDLKWQWEPEKENAVR 1236
Score = 32.3 bits (72), Expect = 0.55
Identities = 39/173 (22%), Positives = 64/173 (36%), Gaps = 34/173 (19%)
Query: 40 MEHEDDPDVDEPLETPLGHILGREPTSSEQGGLEGSGSAAGEGKPALSEEERQEQTKRML 99
++ E++ + E E L R+ E+ E E + E ERQ + + L
Sbjct: 1146 VQQEEEQLLREEPEKRRRQELERQYREEEELQQEEEQLLREEQEKRRQERERQYREEEEL 1205
Query: 100 ELVAQKQRERE-----------------------------EREEREALERERQRRRQGQE 130
+ +KQR R+ E E+ LE + R RQ Q+
Sbjct: 1206 QRQKRKQRYRDEDQRSDLKWQWEPEKENAVRDNKVYCKGRENEQFRQLEDSQLRDRQSQQ 1265
Query: 131 -----LSAARQRLQEDEMRRAAEERRREKAEELAARQRVREKIERDKAERAKK 178
L ++R +E E RR + R EE R+ +E RD+ + +K
Sbjct: 1266 DLQHLLGEQQERDREQERRRWQQRDRHFPEEEQLEREEQKEAKRRDRKSQEEK 1318
Score = 32.3 bits (72), Expect = 0.55
Identities = 24/115 (20%), Positives = 59/115 (51%), Gaps = 24/115 (20%)
Query: 88 EEERQEQTKRMLELVAQK---QREREEREEREALERERQRRR--------------QGQE 130
EEE Q++ +++L +K +RER+ REE E L+R+++++R + ++
Sbjct: 1173 EEELQQEEEQLLREEQEKRRQERERQYREEEE-LQRQKRKQRYRDEDQRSDLKWQWEPEK 1231
Query: 131 LSAARQR------LQEDEMRRAAEERRREKAEELAARQRVREKIERDKAERAKKY 179
+A R + ++ R+ + + R++ + + + E+ ERD+ + +++
Sbjct: 1232 ENAVRDNKVYCKGRENEQFRQLEDSQLRDRQSQQDLQHLLGEQQERDREQERRRW 1286
Score = 29.6 bits (65), Expect = 3.6
Identities = 20/85 (23%), Positives = 43/85 (50%), Gaps = 3/85 (3%)
Query: 91 RQEQTKRMLELVAQKQREREE---REEREALERERQRRRQGQELSAARQRLQEDEMRRAA 147
RQEQ ++ +E Q +R+ + R+ER+ RE ++ Q +E ++ ++ +
Sbjct: 1590 RQEQERKFMEDEQQLRRQEGQQQLRQERDRKFREDEQLLQEREEQQLHRQERDRKFLEEE 1649
Query: 148 EERRREKAEELAARQRVREKIERDK 172
+ RR++ E+ R R+ E ++
Sbjct: 1650 PQLRRQEREQQLRHDRDRKFREEEQ 1674
>gi|44680105 caldesmon 1 isoform 1 [Homo sapiens]
Length = 793
Score = 55.8 bits (133), Expect = 5e-08
Identities = 55/174 (31%), Positives = 87/174 (50%), Gaps = 22/174 (12%)
Query: 21 EKALALTGNQGIEAAMDWLMEHEDDPDVDEPLETPLGHILGREPTSSEQGGLEGSGSAAG 80
E+ + ++ G ++ + E E + DE + H E E+ E + A
Sbjct: 221 EETVVMSLKNGQISSEEPKQEEEREQGSDE-----ISHHEKMEEEDKERAEAERARLEAE 275
Query: 81 EGKPALSEEERQEQTKRML----ELVAQKQREREEREEREALERERQR------RRQGQE 130
E + +E++++ +R E A ++RER E EERE + E +R R + +E
Sbjct: 276 ERERIKAEQDKKIADERARIEAEEKAAAQERERREAEERERMREEEKRAAEERQRIKEEE 335
Query: 131 LSAA--RQRLQEDEMRRAAEERRREKAEELAA---RQRVR-EKIERDKAERAKK 178
AA RQR++E+E +RAAEER+R K EE A RQR R E+ E+ K E K+
Sbjct: 336 KRAAEERQRIKEEE-KRAAEERQRIKEEEKRAAEERQRARAEEEEKAKVEEQKR 388
Score = 55.1 bits (131), Expect = 8e-08
Identities = 40/122 (32%), Positives = 63/122 (51%), Gaps = 16/122 (13%)
Query: 63 EPTSSEQGGLEGSGSAAGEGKPALSEEERQEQTKRML------ELVAQKQREREEREERE 116
E T S GG + EG P + +R E+ +R E KQ+++E E E
Sbjct: 507 ENTFSRPGGRASVDTKEAEGAPQVEAGKRLEELRRRRGETESEEFEKLKQKQQEAALELE 566
Query: 117 ALERERQRRRQGQELSAARQRLQEDEMRRAAEERRREKAEELAARQRVREKIERDKAERA 176
L+++R+ R R+ L+E+E RR EE R+ EE ++R++E+IER +AE A
Sbjct: 567 ELKKKREER---------RKVLEEEEQRRKQEEADRKLREE-EEKRRLKEEIERRRAEAA 616
Query: 177 KK 178
+K
Sbjct: 617 EK 618
Score = 53.9 bits (128), Expect = 2e-07
Identities = 38/114 (33%), Positives = 66/114 (57%), Gaps = 5/114 (4%)
Query: 66 SSEQGGLEGSGSAAGEGKPALSEEERQEQTKRMLELVAQKQREREEREEREALERERQRR 125
+ E+ +E AA + + EER+ + ++QR +EE E+R A ER+R +
Sbjct: 289 ADERARIEAEEKAAAQERERREAEERERMREEEKRAAEERQRIKEE-EKRAAEERQRIKE 347
Query: 126 RQGQELSAARQRLQEDEMRRAAEERRREKAEELAARQRVREKIERDKAERAKKY 179
+ + + RQR++E+E +RAAEER+R +AEE + +V E+ +R+K KK+
Sbjct: 348 EE-KRAAEERQRIKEEE-KRAAEERQRARAEE-EEKAKVEEQ-KRNKQLEEKKH 397
Score = 41.2 bits (95), Expect = 0.001
Identities = 29/95 (30%), Positives = 50/95 (52%), Gaps = 8/95 (8%)
Query: 79 AGEGKPALSEEERQEQTKRML----ELVAQKQREREEREEREALERERQRRRQGQELSAA 134
A E + + EEE++ +R E A ++R+R + EE+ A E ERQR R +E A
Sbjct: 324 AAEERQRIKEEEKRAAEERQRIKEEEKRAAEERQRIKEEEKRAAE-ERQRARAEEEEKA- 381
Query: 135 RQRLQEDEMRRAAEERRREKAEELAARQRVREKIE 169
+++E + + EE++ E ++V +KIE
Sbjct: 382 --KVEEQKRNKQLEEKKHAMQETKIKGEKVEQKIE 414
Score = 40.4 bits (93), Expect = 0.002
Identities = 30/96 (31%), Positives = 50/96 (52%), Gaps = 5/96 (5%)
Query: 81 EGKPALSEEER-QEQTKRMLELVAQKQREREEREEREALERERQRRRQGQELSAARQRLQ 139
E K A E +R +E+ KR E ++QR +EE E+R A ER+R + + + ++
Sbjct: 320 EEKRAAEERQRIKEEEKRAAE---ERQRIKEE-EKRAAEERQRIKEEEKRAAEERQRARA 375
Query: 140 EDEMRRAAEERRREKAEELAARQRVREKIERDKAER 175
E+E + EE++R K E KI+ +K E+
Sbjct: 376 EEEEKAKVEEQKRNKQLEEKKHAMQETKIKGEKVEQ 411
Score = 38.9 bits (89), Expect = 0.006
Identities = 29/101 (28%), Positives = 52/101 (51%), Gaps = 13/101 (12%)
Query: 80 GEGKPALSEEERQEQTKRMLELVAQKQREREEREEREALERERQRRRQGQELSAARQRLQ 139
GE + + EE+ +++ +++ K + E ++ ERE QG + + ++++
Sbjct: 204 GENQVEVMVEEKTTESQEETVVMSLKNGQISSEEPKQEEERE-----QGSDEISHHEKME 258
Query: 140 EDEMRRAAEERRREKAEELAARQRVREKIERDKA---ERAK 177
E++ RA ER R +AEE R R K E+DK ERA+
Sbjct: 259 EEDKERAEAERARLEAEE-----RERIKAEQDKKIADERAR 294
Score = 37.0 bits (84), Expect = 0.023
Identities = 41/180 (22%), Positives = 68/180 (37%), Gaps = 45/180 (25%)
Query: 65 TSSEQGGLEGSGSAAGEGKPALSEEERQEQTKRMLE-------------LVAQKQREREE 111
T++ +EG AA + A EE RQ++ + LE L +R + +
Sbjct: 81 TTTTNTQVEGDDEAAFLERLARREERRQKRLQEALERQKEFDPTITDASLSLPSRRMQND 140
Query: 112 REEREALERE-----RQRRRQGQELSAARQRLQEDEMRRAAEERRREKAEELAARQRVRE 166
E E E+E RQ R + +E + Q+++ R A E ++ +K
Sbjct: 141 TAENETTEKEEKSESRQERYEIEETETVTKSYQKNDWRDAEENKKEDK------------ 188
Query: 167 KIERDKAERAKKYGGSVGSQPPPVAPEPGPVPSS-------------PSQEPPTKREYDQ 213
E+++ E K GS+G V E S S+EP + E +Q
Sbjct: 189 --EKEEEEEEKPKRGSIGENQVEVMVEEKTTESQEETVVMSLKNGQISSEEPKQEEEREQ 246
Score = 33.5 bits (75), Expect = 0.25
Identities = 25/67 (37%), Positives = 38/67 (56%), Gaps = 7/67 (10%)
Query: 104 QKQREREEREE-REALERERQRRRQGQELSAARQRLQEDEMRRAAEERRREKAEELAARQ 162
+++ R++REE R ER +R E AAR+R RRA +ER R+K EE + Q
Sbjct: 7 RRELRRQKREEMRLEAERIAYQRNDDDEEEAARER-----RRRARQERLRQKQEEESLGQ 61
Query: 163 RVREKIE 169
V +++E
Sbjct: 62 -VTDQVE 67
Score = 32.7 bits (73), Expect = 0.42
Identities = 42/138 (30%), Positives = 54/138 (39%), Gaps = 28/138 (20%)
Query: 119 ERERQRRRQGQE---LSAAR---QRLQEDEMRRAAEERRREKAEELAARQRVREKIERDK 172
ER R+ RRQ +E L A R QR +DE A E RRR + E R+R+K E +
Sbjct: 5 ERRRELRRQKREEMRLEAERIAYQRNDDDEEEAARERRRRARQE------RLRQKQEEES 58
Query: 173 AERAKKYGGSVGSQPPPVAPEPGPVPSSPSQEPPTKREYDQCRIQVRLPDGTSLTQTFRA 232
G V Q E S P +E T QV D + +
Sbjct: 59 L-------GQVTDQ-----VEVNAQNSVPDEEAKT----TTTNTQVEGDDEAAFLERLAR 102
Query: 233 REQLAAVRLYVELHRGEE 250
RE+ RL L R +E
Sbjct: 103 REERRQKRLQEALERQKE 120
Score = 32.7 bits (73), Expect = 0.42
Identities = 30/121 (24%), Positives = 57/121 (47%), Gaps = 26/121 (21%)
Query: 78 AAGEGKPALSEEERQ---EQTKRMLELVAQKQREREEREEREALERE------------- 121
AA E + A +EEE + E+ KR +L +K +E + + E +E++
Sbjct: 366 AAEERQRARAEEEEKAKVEEQKRNKQLEEKKHAMQETKIKGEKVEQKIEGKWVNEKKAQE 425
Query: 122 ---------RQRRRQGQELSAARQRLQEDEMRRAAEERRREK-AEELAARQRVREKIERD 171
+Q +G ++ A R++LQED+ EE + EK ++ ++ V+ ++R
Sbjct: 426 DKLQTAVLKKQGEEKGTKVQAKREKLQEDKPTFKKEEIKDEKIKKDKEPKEEVKSFMDRK 485
Query: 172 K 172
K
Sbjct: 486 K 486
Score = 30.4 bits (67), Expect = 2.1
Identities = 24/119 (20%), Positives = 60/119 (50%), Gaps = 14/119 (11%)
Query: 66 SSEQGGLEGSGSAAGEGKPALSEEERQEQTKRMLELVAQKQRER-EEREEREALERER-- 122
+ E+ ++ A E + + EEE++ +R ++++ + EE++ + LE ++
Sbjct: 339 AEERQRIKEEEKRAAEERQRIKEEEKRAAEERQRARAEEEEKAKVEEQKRNKQLEEKKHA 398
Query: 123 --QRRRQGQELS-------AARQRLQEDEMRRAAEERRREKAEELAARQRVREKIERDK 172
+ + +G+++ ++ QED+++ A +++ E E+ Q REK++ DK
Sbjct: 399 MQETKIKGEKVEQKIEGKWVNEKKAQEDKLQTAVLKKQGE--EKGTKVQAKREKLQEDK 455
Score = 29.6 bits (65), Expect = 3.6
Identities = 19/55 (34%), Positives = 29/55 (52%), Gaps = 3/55 (5%)
Query: 81 EGKPALSEEE---RQEQTKRMLELVAQKQREREEREEREALERERQRRRQGQELS 132
E + L EEE +QE+ R L +K+R +EE E R A E++++ LS
Sbjct: 574 ERRKVLEEEEQRRKQEEADRKLREEEEKRRLKEEIERRRAEAAEKRQKMPEDGLS 628
Score = 29.3 bits (64), Expect = 4.7
Identities = 20/83 (24%), Positives = 41/83 (49%), Gaps = 9/83 (10%)
Query: 104 QKQREREEREER--------EALERERQRRRQGQELSAARQRLQEDEMRRAAEERRREKA 155
+K+ E EE+ +R E + E+ Q + + + + Q EE R + +
Sbjct: 189 EKEEEEEEKPKRGSIGENQVEVMVEEKTTESQEETVVMSLKNGQISSEEPKQEEEREQGS 248
Query: 156 EELAARQRVREKI-ERDKAERAK 177
+E++ +++ E+ ER +AERA+
Sbjct: 249 DEISHHEKMEEEDKERAEAERAR 271
Score = 29.3 bits (64), Expect = 4.7
Identities = 15/57 (26%), Positives = 34/57 (59%), Gaps = 4/57 (7%)
Query: 89 EERQEQTKRMLELVAQKQRE----REEREEREALERERQRRRQGQELSAARQRLQED 141
++++E+ +++LE Q++++ R+ REE E + + R+ E + RQ++ ED
Sbjct: 569 KKKREERRKVLEEEEQRRKQEEADRKLREEEEKRRLKEEIERRRAEAAEKRQKMPED 625
>gi|155030232 proline, glutamic acid and leucine rich protein 1 [Homo
sapiens]
Length = 1130
Score = 55.1 bits (131), Expect = 8e-08
Identities = 67/265 (25%), Positives = 100/265 (37%), Gaps = 24/265 (9%)
Query: 16 PRGRAEKALALTGNQGIEAAMDWLMEHEDDPDVDEPLETPLGH---ILGREPTSSEQGGL 72
P G +A TG + E E+ P PL P + G P + L
Sbjct: 803 PSGATPPPIAPTGPPTASPPVPAKEEPEELPAAPGPLPPPPPPPPPVPG--PVTLPPPQL 860
Query: 73 EGSGSAAGEGKPALSEEERQEQTKRMLELVAQKQREREEREEREALERERQRRRQGQELS 132
G+ G G PAL E+ ++ + + + E EE EE E E E + +E
Sbjct: 861 VPEGTPGGGGPPALEED------LTVININSSDEEEEEEEEEEEEEEEEEEEEEDFEEEE 914
Query: 133 AARQRL--QEDEMRRAAEERRREKAEELAARQRVREKIERDKAERAKKY-----GGSV-- 183
+ +E+E EE E+ EL + ++ E ++ E + GG V
Sbjct: 915 EDEEEYFEEEEEEEEEFEEEFEEEEGELEEEEEEEDEEEEEELEEVEDLEFGTAGGEVEE 974
Query: 184 GSQPPPVAPEPGPVPSSPSQEPPTKREYDQCRIQVRLPDGTSLTQTFRAREQLA--AVRL 241
G+ PPP P P P SP + P ++V P GT + LA A+
Sbjct: 975 GAPPPPTLPPALPPPESPPKVQPEPEPEPGLLLEVEEP-GTEEERGADTAPTLAPEALPS 1033
Query: 242 YVELHR-GEELGGGQDPVQLLSGFP 265
E+ R GE G P +L+ P
Sbjct: 1034 QGEVEREGESPAAGPPPQELVEEEP 1058
>gi|15149465 caldesmon 1 isoform 5 [Homo sapiens]
Length = 532
Score = 55.1 bits (131), Expect = 8e-08
Identities = 40/122 (32%), Positives = 63/122 (51%), Gaps = 16/122 (13%)
Query: 63 EPTSSEQGGLEGSGSAAGEGKPALSEEERQEQTKRML------ELVAQKQREREEREERE 116
E T S GG + EG P + +R E+ +R E KQ+++E E E
Sbjct: 246 ENTFSRPGGRASVDTKEAEGAPQVEAGKRLEELRRRRGETESEEFEKLKQKQQEAALELE 305
Query: 117 ALERERQRRRQGQELSAARQRLQEDEMRRAAEERRREKAEELAARQRVREKIERDKAERA 176
L+++R+ R R+ L+E+E RR EE R+ EE ++R++E+IER +AE A
Sbjct: 306 ELKKKREER---------RKVLEEEEQRRKQEEADRKLREE-EEKRRLKEEIERRRAEAA 355
Query: 177 KK 178
+K
Sbjct: 356 EK 357
Score = 32.3 bits (72), Expect = 0.55
Identities = 32/140 (22%), Positives = 56/140 (40%), Gaps = 35/140 (25%)
Query: 65 TSSEQGGLEGSGSAAGEGKPALSEEERQEQTKRMLELVAQ-------------------- 104
T++ +EG AA + A EE RQ++ + LE +
Sbjct: 75 TTTTNTQVEGDDEAAFLERLARREERRQKRLQEALERQKEFDPTITDASLSLPSRRMQND 134
Query: 105 -KQREREEREEREALERERQRRRQGQELSAARQRLQEDEMRRAAEERRREKAEE------ 157
+ E E+EE+ RQ R + +E + Q+++ R A E ++ +K +E
Sbjct: 135 TAENETTEKEEK---SESRQERYEIEETETVTKSYQKNDWRDAEENKKEDKEKEEEEEEK 191
Query: 158 -----LAARQRVREKIERDK 172
+ Q EKI++DK
Sbjct: 192 PKRGSIGENQIKDEKIKKDK 211
Score = 30.8 bits (68), Expect = 1.6
Identities = 27/118 (22%), Positives = 49/118 (41%), Gaps = 6/118 (5%)
Query: 72 LEGSGSAAGEGKPALSEEERQEQTKRMLELVAQKQREREEREEREALERERQRRRQGQEL 131
L GSGS ALS+ Q E +++R + R+ E E + Q
Sbjct: 2 LGGSGSHGRRSLAALSQIAYQRNDDDEEEAARERRRRARQERLRQKQEEESLGQVTDQVE 61
Query: 132 SAARQRLQEDEMRRAAEERRREKAEE------LAARQRVREKIERDKAERAKKYGGSV 183
A+ + ++E + + E +E LA R+ R+K ++ ER K++ ++
Sbjct: 62 VNAQNSVPDEEAKTTTTNTQVEGDDEAAFLERLARREERRQKRLQEALERQKEFDPTI 119
Score = 29.6 bits (65), Expect = 3.6
Identities = 19/55 (34%), Positives = 29/55 (52%), Gaps = 3/55 (5%)
Query: 81 EGKPALSEEE---RQEQTKRMLELVAQKQREREEREEREALERERQRRRQGQELS 132
E + L EEE +QE+ R L +K+R +EE E R A E++++ LS
Sbjct: 313 ERRKVLEEEEQRRKQEEADRKLREEEEKRRLKEEIERRRAEAAEKRQKMPEDGLS 367
Score = 29.3 bits (64), Expect = 4.7
Identities = 15/57 (26%), Positives = 34/57 (59%), Gaps = 4/57 (7%)
Query: 89 EERQEQTKRMLELVAQKQRE----REEREEREALERERQRRRQGQELSAARQRLQED 141
++++E+ +++LE Q++++ R+ REE E + + R+ E + RQ++ ED
Sbjct: 308 KKKREERRKVLEEEEQRRKQEEADRKLREEEEKRRLKEEIERRRAEAAEKRQKMPED 364
>gi|15149463 caldesmon 1 isoform 4 [Homo sapiens]
Length = 558
Score = 55.1 bits (131), Expect = 8e-08
Identities = 40/122 (32%), Positives = 63/122 (51%), Gaps = 16/122 (13%)
Query: 63 EPTSSEQGGLEGSGSAAGEGKPALSEEERQEQTKRML------ELVAQKQREREEREERE 116
E T S GG + EG P + +R E+ +R E KQ+++E E E
Sbjct: 272 ENTFSRPGGRASVDTKEAEGAPQVEAGKRLEELRRRRGETESEEFEKLKQKQQEAALELE 331
Query: 117 ALERERQRRRQGQELSAARQRLQEDEMRRAAEERRREKAEELAARQRVREKIERDKAERA 176
L+++R+ R R+ L+E+E RR EE R+ EE ++R++E+IER +AE A
Sbjct: 332 ELKKKREER---------RKVLEEEEQRRKQEEADRKLREE-EEKRRLKEEIERRRAEAA 381
Query: 177 KK 178
+K
Sbjct: 382 EK 383
Score = 35.8 bits (81), Expect = 0.050
Identities = 33/138 (23%), Positives = 57/138 (41%), Gaps = 32/138 (23%)
Query: 65 TSSEQGGLEGSGSAAGEGKPALSEEERQEQTKRMLE-------------LVAQKQREREE 111
T++ +EG AA + A EE RQ++ + LE L +R + +
Sbjct: 75 TTTTNTQVEGDDEAAFLERLARREERRQKRLQEALERQKEFDPTITDASLSLPSRRMQND 134
Query: 112 REEREALERE-----RQRRRQGQELSAARQRLQEDEMRRAAEERRREKAEELAARQRVRE 166
E E E+E RQ R + +E + Q+++ R A E ++ +K
Sbjct: 135 TAENETTEKEEKSESRQERYEIEETETVTKSYQKNDWRDAEENKKEDK------------ 182
Query: 167 KIERDKAERAKKYGGSVG 184
E+++ E K GS+G
Sbjct: 183 --EKEEEEEEKPKRGSIG 198
Score = 35.8 bits (81), Expect = 0.050
Identities = 21/70 (30%), Positives = 41/70 (58%), Gaps = 2/70 (2%)
Query: 104 QKQREREEREEREALERERQRRRQGQELSAARQRLQEDEMRRAAEERRREK-AEELAARQ 162
+K+ E EE+ +R ++ E Q +G ++ A R++LQED+ EE + EK ++ ++
Sbjct: 183 EKEEEEEEKPKRGSIG-ENQGEEKGTKVQAKREKLQEDKPTFKKEEIKDEKIKKDKEPKE 241
Query: 163 RVREKIERDK 172
V+ ++R K
Sbjct: 242 EVKSFMDRKK 251
Score = 30.8 bits (68), Expect = 1.6
Identities = 27/118 (22%), Positives = 49/118 (41%), Gaps = 6/118 (5%)
Query: 72 LEGSGSAAGEGKPALSEEERQEQTKRMLELVAQKQREREEREEREALERERQRRRQGQEL 131
L GSGS ALS+ Q E +++R + R+ E E + Q
Sbjct: 2 LGGSGSHGRRSLAALSQIAYQRNDDDEEEAARERRRRARQERLRQKQEEESLGQVTDQVE 61
Query: 132 SAARQRLQEDEMRRAAEERRREKAEE------LAARQRVREKIERDKAERAKKYGGSV 183
A+ + ++E + + E +E LA R+ R+K ++ ER K++ ++
Sbjct: 62 VNAQNSVPDEEAKTTTTNTQVEGDDEAAFLERLARREERRQKRLQEALERQKEFDPTI 119
Score = 29.6 bits (65), Expect = 3.6
Identities = 19/55 (34%), Positives = 29/55 (52%), Gaps = 3/55 (5%)
Query: 81 EGKPALSEEE---RQEQTKRMLELVAQKQREREEREEREALERERQRRRQGQELS 132
E + L EEE +QE+ R L +K+R +EE E R A E++++ LS
Sbjct: 339 ERRKVLEEEEQRRKQEEADRKLREEEEKRRLKEEIERRRAEAAEKRQKMPEDGLS 393
Score = 29.3 bits (64), Expect = 4.7
Identities = 15/57 (26%), Positives = 34/57 (59%), Gaps = 4/57 (7%)
Query: 89 EERQEQTKRMLELVAQKQRE----REEREEREALERERQRRRQGQELSAARQRLQED 141
++++E+ +++LE Q++++ R+ REE E + + R+ E + RQ++ ED
Sbjct: 334 KKKREERRKVLEEEEQRRKQEEADRKLREEEEKRRLKEEIERRRAEAAEKRQKMPED 390
>gi|15149467 caldesmon 1 isoform 3 [Homo sapiens]
Length = 564
Score = 55.1 bits (131), Expect = 8e-08
Identities = 40/122 (32%), Positives = 63/122 (51%), Gaps = 16/122 (13%)
Query: 63 EPTSSEQGGLEGSGSAAGEGKPALSEEERQEQTKRML------ELVAQKQREREEREERE 116
E T S GG + EG P + +R E+ +R E KQ+++E E E
Sbjct: 278 ENTFSRPGGRASVDTKEAEGAPQVEAGKRLEELRRRRGETESEEFEKLKQKQQEAALELE 337
Query: 117 ALERERQRRRQGQELSAARQRLQEDEMRRAAEERRREKAEELAARQRVREKIERDKAERA 176
L+++R+ R R+ L+E+E RR EE R+ EE ++R++E+IER +AE A
Sbjct: 338 ELKKKREER---------RKVLEEEEQRRKQEEADRKLREE-EEKRRLKEEIERRRAEAA 387
Query: 177 KK 178
+K
Sbjct: 388 EK 389
Score = 35.8 bits (81), Expect = 0.050
Identities = 33/138 (23%), Positives = 57/138 (41%), Gaps = 32/138 (23%)
Query: 65 TSSEQGGLEGSGSAAGEGKPALSEEERQEQTKRMLE-------------LVAQKQREREE 111
T++ +EG AA + A EE RQ++ + LE L +R + +
Sbjct: 81 TTTTNTQVEGDDEAAFLERLARREERRQKRLQEALERQKEFDPTITDASLSLPSRRMQND 140
Query: 112 REEREALERE-----RQRRRQGQELSAARQRLQEDEMRRAAEERRREKAEELAARQRVRE 166
E E E+E RQ R + +E + Q+++ R A E ++ +K
Sbjct: 141 TAENETTEKEEKSESRQERYEIEETETVTKSYQKNDWRDAEENKKEDK------------ 188
Query: 167 KIERDKAERAKKYGGSVG 184
E+++ E K GS+G
Sbjct: 189 --EKEEEEEEKPKRGSIG 204
Score = 35.8 bits (81), Expect = 0.050
Identities = 21/70 (30%), Positives = 41/70 (58%), Gaps = 2/70 (2%)
Query: 104 QKQREREEREEREALERERQRRRQGQELSAARQRLQEDEMRRAAEERRREK-AEELAARQ 162
+K+ E EE+ +R ++ E Q +G ++ A R++LQED+ EE + EK ++ ++
Sbjct: 189 EKEEEEEEKPKRGSIG-ENQGEEKGTKVQAKREKLQEDKPTFKKEEIKDEKIKKDKEPKE 247
Query: 163 RVREKIERDK 172
V+ ++R K
Sbjct: 248 EVKSFMDRKK 257
Score = 33.5 bits (75), Expect = 0.25
Identities = 25/67 (37%), Positives = 38/67 (56%), Gaps = 7/67 (10%)
Query: 104 QKQREREEREE-REALERERQRRRQGQELSAARQRLQEDEMRRAAEERRREKAEELAARQ 162
+++ R++REE R ER +R E AAR+R RRA +ER R+K EE + Q
Sbjct: 7 RRELRRQKREEMRLEAERIAYQRNDDDEEEAARER-----RRRARQERLRQKQEEESLGQ 61
Query: 163 RVREKIE 169
V +++E
Sbjct: 62 -VTDQVE 67
Score = 32.7 bits (73), Expect = 0.42
Identities = 42/138 (30%), Positives = 54/138 (39%), Gaps = 28/138 (20%)
Query: 119 ERERQRRRQGQE---LSAAR---QRLQEDEMRRAAEERRREKAEELAARQRVREKIERDK 172
ER R+ RRQ +E L A R QR +DE A E RRR + E R+R+K E +
Sbjct: 5 ERRRELRRQKREEMRLEAERIAYQRNDDDEEEAARERRRRARQE------RLRQKQEEES 58
Query: 173 AERAKKYGGSVGSQPPPVAPEPGPVPSSPSQEPPTKREYDQCRIQVRLPDGTSLTQTFRA 232
G V Q E S P +E T QV D + +
Sbjct: 59 L-------GQVTDQ-----VEVNAQNSVPDEEAKT----TTTNTQVEGDDEAAFLERLAR 102
Query: 233 REQLAAVRLYVELHRGEE 250
RE+ RL L R +E
Sbjct: 103 REERRQKRLQEALERQKE 120
Score = 29.6 bits (65), Expect = 3.6
Identities = 19/55 (34%), Positives = 29/55 (52%), Gaps = 3/55 (5%)
Query: 81 EGKPALSEEE---RQEQTKRMLELVAQKQREREEREEREALERERQRRRQGQELS 132
E + L EEE +QE+ R L +K+R +EE E R A E++++ LS
Sbjct: 345 ERRKVLEEEEQRRKQEEADRKLREEEEKRRLKEEIERRRAEAAEKRQKMPEDGLS 399
Score = 29.3 bits (64), Expect = 4.7
Identities = 15/57 (26%), Positives = 34/57 (59%), Gaps = 4/57 (7%)
Query: 89 EERQEQTKRMLELVAQKQRE----REEREEREALERERQRRRQGQELSAARQRLQED 141
++++E+ +++LE Q++++ R+ REE E + + R+ E + RQ++ ED
Sbjct: 340 KKKREERRKVLEEEEQRRKQEEADRKLREEEEKRRLKEEIERRRAEAAEKRQKMPED 396
>gi|4826657 caldesmon 1 isoform 2 [Homo sapiens]
Length = 538
Score = 55.1 bits (131), Expect = 8e-08
Identities = 40/122 (32%), Positives = 63/122 (51%), Gaps = 16/122 (13%)
Query: 63 EPTSSEQGGLEGSGSAAGEGKPALSEEERQEQTKRML------ELVAQKQREREEREERE 116
E T S GG + EG P + +R E+ +R E KQ+++E E E
Sbjct: 252 ENTFSRPGGRASVDTKEAEGAPQVEAGKRLEELRRRRGETESEEFEKLKQKQQEAALELE 311
Query: 117 ALERERQRRRQGQELSAARQRLQEDEMRRAAEERRREKAEELAARQRVREKIERDKAERA 176
L+++R+ R R+ L+E+E RR EE R+ EE ++R++E+IER +AE A
Sbjct: 312 ELKKKREER---------RKVLEEEEQRRKQEEADRKLREE-EEKRRLKEEIERRRAEAA 361
Query: 177 KK 178
+K
Sbjct: 362 EK 363
Score = 33.5 bits (75), Expect = 0.25
Identities = 25/67 (37%), Positives = 38/67 (56%), Gaps = 7/67 (10%)
Query: 104 QKQREREEREE-REALERERQRRRQGQELSAARQRLQEDEMRRAAEERRREKAEELAARQ 162
+++ R++REE R ER +R E AAR+R RRA +ER R+K EE + Q
Sbjct: 7 RRELRRQKREEMRLEAERIAYQRNDDDEEEAARER-----RRRARQERLRQKQEEESLGQ 61
Query: 163 RVREKIE 169
V +++E
Sbjct: 62 -VTDQVE 67
Score = 32.7 bits (73), Expect = 0.42
Identities = 42/138 (30%), Positives = 54/138 (39%), Gaps = 28/138 (20%)
Query: 119 ERERQRRRQGQE---LSAAR---QRLQEDEMRRAAEERRREKAEELAARQRVREKIERDK 172
ER R+ RRQ +E L A R QR +DE A E RRR + E R+R+K E +
Sbjct: 5 ERRRELRRQKREEMRLEAERIAYQRNDDDEEEAARERRRRARQE------RLRQKQEEES 58
Query: 173 AERAKKYGGSVGSQPPPVAPEPGPVPSSPSQEPPTKREYDQCRIQVRLPDGTSLTQTFRA 232
G V Q E S P +E T QV D + +
Sbjct: 59 L-------GQVTDQ-----VEVNAQNSVPDEEAKT----TTTNTQVEGDDEAAFLERLAR 102
Query: 233 REQLAAVRLYVELHRGEE 250
RE+ RL L R +E
Sbjct: 103 REERRQKRLQEALERQKE 120
Score = 32.3 bits (72), Expect = 0.55
Identities = 32/140 (22%), Positives = 56/140 (40%), Gaps = 35/140 (25%)
Query: 65 TSSEQGGLEGSGSAAGEGKPALSEEERQEQTKRMLELVAQ-------------------- 104
T++ +EG AA + A EE RQ++ + LE +
Sbjct: 81 TTTTNTQVEGDDEAAFLERLARREERRQKRLQEALERQKEFDPTITDASLSLPSRRMQND 140
Query: 105 -KQREREEREEREALERERQRRRQGQELSAARQRLQEDEMRRAAEERRREKAEE------ 157
+ E E+EE+ RQ R + +E + Q+++ R A E ++ +K +E
Sbjct: 141 TAENETTEKEEK---SESRQERYEIEETETVTKSYQKNDWRDAEENKKEDKEKEEEEEEK 197
Query: 158 -----LAARQRVREKIERDK 172
+ Q EKI++DK
Sbjct: 198 PKRGSIGENQIKDEKIKKDK 217
Score = 29.6 bits (65), Expect = 3.6
Identities = 19/55 (34%), Positives = 29/55 (52%), Gaps = 3/55 (5%)
Query: 81 EGKPALSEEE---RQEQTKRMLELVAQKQREREEREEREALERERQRRRQGQELS 132
E + L EEE +QE+ R L +K+R +EE E R A E++++ LS
Sbjct: 319 ERRKVLEEEEQRRKQEEADRKLREEEEKRRLKEEIERRRAEAAEKRQKMPEDGLS 373
Score = 29.3 bits (64), Expect = 4.7
Identities = 15/57 (26%), Positives = 34/57 (59%), Gaps = 4/57 (7%)
Query: 89 EERQEQTKRMLELVAQKQRE----REEREEREALERERQRRRQGQELSAARQRLQED 141
++++E+ +++LE Q++++ R+ REE E + + R+ E + RQ++ ED
Sbjct: 314 KKKREERRKVLEEEEQRRKQEEADRKLREEEEKRRLKEEIERRRAEAAEKRQKMPED 370
>gi|78042577 MAP7 domain containing 1 [Homo sapiens]
Length = 841
Score = 54.7 bits (130), Expect = 1e-07
Identities = 37/111 (33%), Positives = 56/111 (50%), Gaps = 14/111 (12%)
Query: 83 KPALSEEERQEQTKRMLEL--VAQKQREREEREEREALERERQRRRQGQELSAARQRLQE 140
KP +R+E T+ + E A++QREREE+E R ER+++ R + A + +E
Sbjct: 588 KPMAGTTDREEATRLLAEKRRQAREQREREEQERRLQAERDKRMREEQLAREAEARAERE 647
Query: 141 DEMRRAAEERRREKA------------EELAARQRVREKIERDKAERAKKY 179
E RR E+ REKA ++ A R RE+ ER + ER K +
Sbjct: 648 AEARRREEQEAREKAQAEQEEQERLQKQKEEAEARSREEAERQRLEREKHF 698
Score = 54.3 bits (129), Expect = 1e-07
Identities = 44/148 (29%), Positives = 66/148 (44%), Gaps = 31/148 (20%)
Query: 91 RQEQTKRMLELVAQKQREREEREEREALER-----ERQRRRQGQELSAARQRLQEDEMRR 145
R+EQ R E A+++ E REE+EA E+ E Q R Q Q+ A + +E E +R
Sbjct: 632 REEQLAREAEARAEREAEARRREEQEAREKAQAEQEEQERLQKQKEEAEARSREEAERQR 691
Query: 146 AAEER-----------RREKAEELAARQRVREKIERDKAERAKKYGGSVGSQPPPV---- 190
E+ RR++ EE+ R R + ++ K ++ K + GS P PV
Sbjct: 692 LEREKHFQQQEQERQERRKRLEEIMKRTR-KSEVSETKQKQDSKEANANGSSPEPVKAVE 750
Query: 191 APEPG----------PVPSSPSQEPPTK 208
A PG P+P P P+K
Sbjct: 751 ARSPGLQKEAVQKEEPIPQEPQWSLPSK 778
Score = 40.4 bits (93), Expect = 0.002
Identities = 35/114 (30%), Positives = 61/114 (53%), Gaps = 10/114 (8%)
Query: 79 AGEGKPALSEEERQEQTKRMLELVAQKQREREEREEREALE----RERQRRRQGQELSAA 134
AGE + L++E R+E+ K L A+K E+ E+ +AL +ER+RR + Q L A
Sbjct: 135 AGE-RHKLAKERREERAKY---LAAKKAVWLEKEEKAKALREKQLQERRRRLEEQRLKAE 190
Query: 135 RQRLQEDEMRRAAEERRREKAEELAARQRVREKIERDKAERAKKYGGSVGSQPP 188
++R +E +R E+ +E+ E AA QR +K + ++ + G++ P
Sbjct: 191 QRRAALEERQRQKLEKNKERYE--AAIQRSVKKTWAEIRQQRWSWAGALHHSSP 242
Score = 38.5 bits (88), Expect = 0.008
Identities = 28/125 (22%), Positives = 55/125 (44%), Gaps = 6/125 (4%)
Query: 53 ETPLGHILGREPTSSEQGGLEG-----SGSAAGEGKPALSEEERQEQTKRMLELVAQKQR 107
E+P R PT G + S + PA +++ K+ E +
Sbjct: 85 ESPSSEAKSRGPTPPAMGPRDARPPRRSSQPSPTAVPASDSPPTKQEVKKAGERHKLAKE 144
Query: 108 EREEREEREALERERQRRRQGQELSAARQRLQEDEMRRAAEERRREKAEELAARQRVREK 167
REER + A ++ ++ ++ A R++ ++ RR E+R + + A +R R+K
Sbjct: 145 RREERAKYLAAKKAVWLEKE-EKAKALREKQLQERRRRLEEQRLKAEQRRAALEERQRQK 203
Query: 168 IERDK 172
+E++K
Sbjct: 204 LEKNK 208
Score = 32.3 bits (72), Expect = 0.55
Identities = 34/175 (19%), Positives = 56/175 (32%), Gaps = 51/175 (29%)
Query: 77 SAAGEGKPALSEEERQEQTKRMLELVAQKQREREEREEREALERERQRRRQGQELSAARQ 136
+A G P E K+ +K +ERE +E+ AL RER +++ ++ R
Sbjct: 395 NAGGSPAPVRRRPEASPVQKK-----EKKDKERENEKEKSALARERSLKKRQSLPASPRA 449
Query: 137 RLQEDEMRRAAEE----------------------------------------------R 150
RL + + R
Sbjct: 450 RLSASTASELSPKSKARPSSPSTSWHRPASPCPSPGPGHTLPPKPPSPRGTTASPKGRVR 509
Query: 151 RREKAEELAARQRVREKIERDKAERAKKYGGSVGSQPPPVAPEPGPVPSSPSQEP 205
R+E+A+E + +K + + +K + S P AP P P P Q P
Sbjct: 510 RKEEAKESPSAAGPEDKSQSKRRASNEKESAAPASPAPSPAPSPTPAPPQKEQPP 564
Score = 28.9 bits (63), Expect = 6.1
Identities = 22/85 (25%), Positives = 40/85 (47%), Gaps = 6/85 (7%)
Query: 121 ERQRRRQGQELSAARQRLQEDEMRRAAE---ERRREKAEELAARQRVREKIERDKAERAK 177
ER++ G + R+R + +++ + ER EK + AR+R +K + A
Sbjct: 390 ERRKPNAGGSPAPVRRRPEASPVQKKEKKDKERENEKEKSALARERSLKKRQSLPASPRA 449
Query: 178 KYGGSVGSQPPPVAPEPGPVPSSPS 202
+ S S+ ++P+ PSSPS
Sbjct: 450 RLSASTASE---LSPKSKARPSSPS 471
>gi|239747134 PREDICTED: hypothetical protein XP_002343921 [Homo
sapiens]
Length = 600
Score = 54.3 bits (129), Expect = 1e-07
Identities = 44/137 (32%), Positives = 66/137 (48%), Gaps = 18/137 (13%)
Query: 88 EEERQEQTKRMLELVAQKQRERE-EREEREALERERQRRRQGQELSAARQRLQE---DEM 143
+ ER QT R A+++RERE ER+ + A ERE + R + ++ R+R E D
Sbjct: 352 DRERNRQTGREGRRQAERERERERERDRQSAREREERERDRDRDRQKERERQTEKDRDGQ 411
Query: 144 RRAAEERRREK---AEELAARQRVREKIERDKAERAKKYGGSVGSQ---------PPPVA 191
R ++R REK +E R R REK + + +R ++ G Q PPP
Sbjct: 412 RETEKQREREKDRESERGRERGREREKQKGRERDRERQTDRQAGRQRKRSTLYVNPPPRT 471
Query: 192 PEPGPVPSSPSQEPPTK 208
G V S P++ PT+
Sbjct: 472 ARSGVVQSDPNR--PTR 486
Score = 53.1 bits (126), Expect = 3e-07
Identities = 32/94 (34%), Positives = 50/94 (53%), Gaps = 4/94 (4%)
Query: 88 EEERQEQTKRMLELVAQKQREREEREEREAL---ERERQRRRQGQELSAARQRLQEDEMR 144
E+ER+ QT R + +K+R R++ ERE ER R R+ GQ RQR E E
Sbjct: 102 EKERERQTDRERDRQREKERNRQKERERETEREGERGRDRQTDGQR-ERERQRDAEKERE 160
Query: 145 RAAEERRREKAEELAARQRVREKIERDKAERAKK 178
R + R+ + E ++R REK +++ ER ++
Sbjct: 161 RQTDRERQRQTERNRQKEREREKNRQERRERERQ 194
Score = 53.1 bits (126), Expect = 3e-07
Identities = 35/92 (38%), Positives = 48/92 (52%), Gaps = 2/92 (2%)
Query: 88 EEERQEQTKRMLELVAQKQREREEREERE-ALERERQRRRQGQELSAARQRLQEDEMRRA 146
E ER+ KR E +++RER+ ER+ ERER+R+RQ E+ R R E RR
Sbjct: 308 ERERERNRKRERERERERERERQRETERDREKERERKRKRQ-TEMDRERNRQTGREGRRQ 366
Query: 147 AEERRREKAEELAARQRVREKIERDKAERAKK 178
AE R + E R RE+ ERD+ +K
Sbjct: 367 AERERERERERDRQSAREREERERDRDRDRQK 398
Score = 49.7 bits (117), Expect = 3e-06
Identities = 29/98 (29%), Positives = 49/98 (50%), Gaps = 3/98 (3%)
Query: 83 KPALSEEERQEQTKRMLELVAQKQRERE---EREEREALERERQRRRQGQELSAARQRLQ 139
+ A E ERQ +R + +Q+ERE R+ER ER+R++ + ++ + R R +
Sbjct: 153 RDAEKERERQTDRERQRQTERNRQKEREREKNRQERRERERQREKENKTEDRHSERGRER 212
Query: 140 EDEMRRAAEERRREKAEELAARQRVREKIERDKAERAK 177
E E E R+ + + RQR E+ +AER +
Sbjct: 213 ERERETETETERKRQTDRERDRQRKTEREREKQAERER 250
Score = 49.3 bits (116), Expect = 4e-06
Identities = 28/93 (30%), Positives = 53/93 (56%), Gaps = 3/93 (3%)
Query: 87 SEEERQEQTKRMLELVAQKQREREEREEREA-LERERQRRRQGQELSAARQRLQEDEMRR 145
+E ER++Q +R E ++++ ER++ ERE +R+R RR++ +E R+R + E R
Sbjct: 238 TEREREKQAER--ERASERETERDKERERERDRDRDRDRRQKERERQTDRKRQRRTERDR 295
Query: 146 AAEERRREKAEELAARQRVREKIERDKAERAKK 178
E +R + E R+R R++ + ER ++
Sbjct: 296 ETERKRERQRERERERERNRKRERERERERERE 328
Score = 48.9 bits (115), Expect = 6e-06
Identities = 31/91 (34%), Positives = 50/91 (54%), Gaps = 7/91 (7%)
Query: 87 SEEERQEQTKRMLELVAQKQREREEREEREALERERQRRRQ-----GQELSAARQRLQED 141
+E +R+ + KR + +++RER + ERE ERER+R RQ +E R+R ++
Sbjct: 291 TERDRETERKRERQRERERERERNRKRERER-ERERERERQRETERDREKERERKRKRQT 349
Query: 142 EMRRAAEERRREKAEELAARQRVREKIERDK 172
EM R + + A R+R RE+ ERD+
Sbjct: 350 EMDRERNRQTGREGRRQAERERERER-ERDR 379
Score = 47.4 bits (111), Expect = 2e-05
Identities = 36/106 (33%), Positives = 51/106 (48%), Gaps = 15/106 (14%)
Query: 87 SEEERQEQTKRMLELVAQKQREREEREEREAL-----------ERERQRRRQGQELSAAR 135
+E ER+ QT R + + +RERE++ ERE ERER R R R
Sbjct: 220 TETERKRQTDRERDRQRKTEREREKQAERERASERETERDKERERERDRDRDRDRRQKER 279
Query: 136 QRLQEDEMRRAAEERRRE---KAEELAARQRVREKIERDKAERAKK 178
+R Q D R+ ER RE K E R+R RE+ + + ER ++
Sbjct: 280 ER-QTDRKRQRRTERDRETERKRERQRERERERERNRKRERERERE 324
Score = 47.4 bits (111), Expect = 2e-05
Identities = 28/93 (30%), Positives = 45/93 (48%), Gaps = 1/93 (1%)
Query: 87 SEEERQEQTKRMLELVAQKQREREEREEREALERERQRR-RQGQELSAARQRLQEDEMRR 145
SE E + +R E + R+R ++E +R+RQRR + +E R+R +E E R
Sbjct: 252 SERETERDKERERERDRDRDRDRRQKERERQTDRKRQRRTERDRETERKRERQRERERER 311
Query: 146 AAEERRREKAEELAARQRVREKIERDKAERAKK 178
+R + E R+R RE + ER +K
Sbjct: 312 ERNRKRERERERERERERQRETERDREKERERK 344
Score = 47.0 bits (110), Expect = 2e-05
Identities = 36/116 (31%), Positives = 55/116 (47%), Gaps = 5/116 (4%)
Query: 62 REPTSSEQGGLEGSGSAAGEGKPALSEEERQEQTKRMLELVAQKQREREEREEREALERE 121
R P S E G G A + E RQ++ +R E ++Q ERE +RE RE
Sbjct: 29 RRPGSQESPRRRGLGQAHKDADGDDRERNRQKERERRRE---KRQTERETDRKRER-RRE 84
Query: 122 RQRRRQGQELSAARQRLQEDEMRRAAEERRREKAEELAARQRVREKIERDKAERAK 177
+ R R+ ++ RQR +E E R + R + E+ RQ+ RE+ + ER +
Sbjct: 85 KDRHRK-RDRHRERQRDREKERERQTDRERDRQREKERNRQKERERETEREGERGR 139
Score = 46.6 bits (109), Expect = 3e-05
Identities = 37/157 (23%), Positives = 64/157 (40%), Gaps = 6/157 (3%)
Query: 28 GNQGIEAAMDWLMEHEDDPDVDEPLETPLGHILGREPTSSEQGGLEGSGSAAGEGKPALS 87
G + E D E E D + +T RE + Q E E K
Sbjct: 145 GQRERERQRDAEKERERQTDRERQRQTERNRQKEREREKNRQERRERERQREKENKTEDR 204
Query: 88 EEERQEQTKRMLELVAQKQREREEREEREALER-ERQRRRQGQELSAARQRLQEDEMRRA 146
ER + +R E + +R+R+ ER+ + ER+R +Q + A+ + + D+ R
Sbjct: 205 HSERGRERERERETETETERKRQTDRERDRQRKTEREREKQAERERASERETERDKERER 264
Query: 147 AEER-----RREKAEELAARQRVREKIERDKAERAKK 178
+R RR+K E ++ + + ERD+ K+
Sbjct: 265 ERDRDRDRDRRQKERERQTDRKRQRRTERDRETERKR 301
Score = 46.6 bits (109), Expect = 3e-05
Identities = 35/96 (36%), Positives = 52/96 (54%), Gaps = 6/96 (6%)
Query: 88 EEERQEQTKRM--LELVAQKQREREEREEREALERERQRRRQGQ-ELSAARQRLQEDEMR 144
E ERQ KR E + +R+RE + ERE ERER R+R+ + E R+R +E E
Sbjct: 278 ERERQTDRKRQRRTERDRETERKRERQRERER-ERERNRKRERERERERERERQRETERD 336
Query: 145 RAAEERRREKAEELAARQRVRE--KIERDKAERAKK 178
R E R+ K + R+R R+ + R +AER ++
Sbjct: 337 REKERERKRKRQTEMDRERNRQTGREGRRQAERERE 372
Score = 46.2 bits (108), Expect = 4e-05
Identities = 26/96 (27%), Positives = 49/96 (51%), Gaps = 5/96 (5%)
Query: 88 EEERQEQTKRMLELVAQKQREREEREEREALERERQR-----RRQGQELSAARQRLQEDE 142
+ ER+ ++R E +++RER+ +R+ ++ER+R R++ E +R +E +
Sbjct: 245 QAERERASERETERDKERERERDRDRDRDRRQKERERQTDRKRQRRTERDRETERKRERQ 304
Query: 143 MRRAAEERRREKAEELAARQRVREKIERDKAERAKK 178
R E R K E R+R RE+ + +R K+
Sbjct: 305 RERERERERNRKRERERERERERERQRETERDREKE 340
Score = 44.7 bits (104), Expect = 1e-04
Identities = 27/89 (30%), Positives = 46/89 (51%), Gaps = 5/89 (5%)
Query: 88 EEERQEQTKRMLELVAQKQRERE-EREEREALERERQRRRQGQELSAARQRLQEDEMRRA 146
E ER+ + +R + ++ RE+E ER+ + E +R+R RQ + R Q + R
Sbjct: 318 ERERERERERERQRETERDREKERERKRKRQTEMDRERNRQ----TGREGRRQAERERER 373
Query: 147 AEERRREKAEELAARQRVREKIERDKAER 175
ER R+ A E R+R R++ + + ER
Sbjct: 374 ERERDRQSAREREERERDRDRDRQKERER 402
Score = 43.9 bits (102), Expect = 2e-04
Identities = 33/140 (23%), Positives = 60/140 (42%), Gaps = 7/140 (5%)
Query: 41 EHEDDPDVDEPLETPLGHILGREPTSSEQGGLEGSGSAAGEGKPALSEEERQEQTKRMLE 100
E + D + D E RE + +G G+ E ERQ ++ E
Sbjct: 106 ERQTDRERDRQREKERNRQKERERETEREGERGRDRQTDGQ-----RERERQRDAEKERE 160
Query: 101 LVAQKQRERE-EREEREALERERQRR-RQGQELSAARQRLQEDEMRRAAEERRREKAEEL 158
++R+R+ ER ++ ERE+ R+ R+ +E ++ ED ER RE+ E
Sbjct: 161 RQTDRERQRQTERNRQKEREREKNRQERRERERQREKENKTEDRHSERGRERERERETET 220
Query: 159 AARQRVREKIERDKAERAKK 178
++ + ERD+ + ++
Sbjct: 221 ETERKRQTDRERDRQRKTER 240
Score = 43.9 bits (102), Expect = 2e-04
Identities = 45/163 (27%), Positives = 70/163 (42%), Gaps = 27/163 (16%)
Query: 41 EHEDDPDVDEPLETPLGHILGREPTSSEQGGLEGSGSAAGEGKPALSEEERQEQTKRMLE 100
E E + + ET GR+ + Q E A E + ++ ERQ QT+R +
Sbjct: 118 EKERNRQKERERETEREGERGRDRQTDGQRERERQRDAEKE-RERQTDRERQRQTERNRQ 176
Query: 101 LVAQKQREREEREERE----------------ALERER--------QRRRQGQELSAARQ 136
++++ R+ER ERE ERER +R+RQ + RQ
Sbjct: 177 KEREREKNRQERRERERQREKENKTEDRHSERGRERERERETETETERKRQ-TDRERDRQ 235
Query: 137 RLQEDEMRRAAEERRREKAEELAARQRVREK-IERDKAERAKK 178
R E E + AE R + E ++R RE+ +RD+ R K+
Sbjct: 236 RKTEREREKQAERERASERETERDKERERERDRDRDRDRRQKE 278
Score = 42.7 bits (99), Expect = 4e-04
Identities = 28/94 (29%), Positives = 51/94 (54%), Gaps = 5/94 (5%)
Query: 88 EEER---QEQTKRMLELVAQKQREREEREERE-ALERERQRRRQGQELSAARQRLQEDEM 143
E ER +++ +R E Q R+R+ R ER+ ER+R+R+R+ +E R R +E E
Sbjct: 263 ERERDRDRDRDRRQKERERQTDRKRQRRTERDRETERKRERQRE-RERERERNRKRERER 321
Query: 144 RRAAEERRREKAEELAARQRVREKIERDKAERAK 177
R E R+ + E ++R R++ + + +R +
Sbjct: 322 ERERERERQRETERDREKERERKRKRQTEMDRER 355
Score = 42.7 bits (99), Expect = 4e-04
Identities = 40/169 (23%), Positives = 80/169 (47%), Gaps = 13/169 (7%)
Query: 89 EERQEQTKRMLELVAQKQREREEREEREALERERQRRRQGQELSAARQRLQEDEMRRAAE 148
+ RQ++ +R + Q++ ER+ ER+ ER+R+R R+ +E + R+R +E E R +
Sbjct: 273 DRRQKERERQTDRKRQRRTERDRETERKR-ERQRERERE-RERNRKRERERERERERERQ 330
Query: 149 -ERRREKAEELAARQRVREKIERDKAERAKKYGGSVGSQPPPVAPEPGPVPSSPSQEPPT 207
E R++ +E +++ + +++R++ + + G + E + +E
Sbjct: 331 RETERDREKERERKRKRQTEMDRERNRQTGREGRRQAERERERERERDRQSAREREERER 390
Query: 208 KREYDQCRIQVRLP----DGTSLTQTFRAREQLAAVRLYVELHRGEELG 252
R+ D+ + + R DG T+ R RE+ E RG E G
Sbjct: 391 DRDRDRQKERERQTEKDRDGQRETEKQREREKDR------ESERGRERG 433
Score = 42.0 bits (97), Expect = 7e-04
Identities = 34/104 (32%), Positives = 53/104 (50%), Gaps = 12/104 (11%)
Query: 79 AGEGKPALSEEERQEQTKRMLELVAQKQRERE---EREEREALERERQRRRQGQELSAAR 135
A E + +E +E+ + QK+RER+ +R+ R +RE +R+R+ Q R
Sbjct: 251 ASERETERDKERERERDRDRDRDRRQKERERQTDRKRQRRTERDRETERKRERQ-----R 305
Query: 136 QRLQEDEMRRAAE-ERRREKAEELAARQRVREKIERDKAERAKK 178
+R +E E R E ER RE+ E RQR E+ + ER +K
Sbjct: 306 ERERERERNRKRERERERERERE---RQRETERDREKERERKRK 346
Score = 39.3 bits (90), Expect = 0.005
Identities = 33/127 (25%), Positives = 55/127 (43%), Gaps = 5/127 (3%)
Query: 53 ETPLGHILGREPTSSEQGGLEGSGSAAGEGKPALSEEERQEQTKRMLELVAQKQREREER 112
E+P LG+ ++ E + E + + ER+ KR + R+R+
Sbjct: 35 ESPRRRGLGQAHKDADGDDRERNRQKERERRREKRQTERETDRKRERRREKDRHRKRDRH 94
Query: 113 EEREALERERQRRRQGQELSAARQRLQEDEMRRAAEERRREKAEELAARQRVRE-KIERD 171
ER+ +RE++R RQ R R +E E R E R + E R R + + ER+
Sbjct: 95 RERQR-DREKERERQ---TDRERDRQREKERNRQKERERETEREGERGRDRQTDGQRERE 150
Query: 172 KAERAKK 178
+ A+K
Sbjct: 151 RQRDAEK 157
Database: hs.faa
Posted date: Aug 4, 2009 4:42 PM
Number of letters in database: 18,247,518
Number of sequences in database: 37,866
Lambda K H
0.311 0.130 0.361
Gapped
Lambda K H
0.267 0.0410 0.140
Matrix: BLOSUM62
Gap Penalties: Existence: 11, Extension: 1
Number of Hits to DB: 13,622,179
Number of Sequences: 37866
Number of extensions: 791545
Number of successful extensions: 25337
Number of sequences better than 10.0: 30
Number of HSP's better than 10.0 without gapping: 669
Number of HSP's successfully gapped in prelim test: 1030
Number of HSP's that attempted gapping in prelim test: 8851
Number of HSP's gapped (non-prelim): 8577
length of query: 312
length of database: 18,247,518
effective HSP length: 102
effective length of query: 210
effective length of database: 14,385,186
effective search space: 3020889060
effective search space used: 3020889060
T: 11
A: 40
X1: 16 ( 7.2 bits)
X2: 38 (14.6 bits)
X3: 64 (24.7 bits)
S1: 42 (21.8 bits)
S2: 62 (28.5 bits)
Search results were obtained with NCBI BLAST and RefSeq entries.
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Guide to the Human Genome
Copyright © 2010 by Stewart Scherer. All rights reserved.