Search of human proteins with 21361458

Search of human proteins with 21361458

BLASTP 2.2.11 [Jun-05-2005]


Reference: Altschul, Stephen F., Thomas L. Madden, Alejandro A. Schaffer, 
Jinghui Zhang, Zheng Zhang, Webb Miller, and David J. Lipman (1997), 
"Gapped BLAST and PSI-BLAST: a new generation of protein database search
programs",  Nucleic Acids Res. 25:3389-3402.

Query= gi|21361458 Rho guanine nucleotide exchange factor (GEF) 17
[Homo sapiens]
         (2063 letters)

Database: hs.faa 
           37,866 sequences; 18,247,518 total letters

Searching..................................................done

                                                                 Score    E
Sequences producing significant alignments:                      (bits) Value

gi|21361458 Rho guanine nucleotide exchange factor (GEF) 17 [Hom...  4171   0.0  
gi|62548864 Rho guanine nucleotide exchange factor 10 [Homo sapi...   166   2e-40
gi|58761492 Rho guanine nucleotide exchange factor (GEF) 10-like...   162   3e-39
gi|74136547 Rho guanine nucleotide exchange factor (GEF) 10-like...   162   3e-39
gi|194578923 sperm associated antigen 9 isoform 1 [Homo sapiens]      156   2e-37
gi|27436920 sperm associated antigen 9 isoform 3 [Homo sapiens]       156   2e-37
gi|94557295 mitogen-activated protein kinase 8 interacting prote...   144   9e-34
gi|94557297 mitogen-activated protein kinase 8 interacting prote...   144   9e-34
gi|82546845 breakpoint cluster region isoform 2 [Homo sapiens]        134   9e-31
gi|82546843 breakpoint cluster region isoform 1 [Homo sapiens]        134   9e-31
gi|34452732 phosphatidylinositol-3,4,5-trisphosphate-dependent R...   112   4e-24
gi|229094128 active breakpoint cluster region-related  protein i...   109   2e-23
gi|38679957 active breakpoint cluster region-related  protein is...   109   2e-23
gi|38679954 active breakpoint cluster region-related  protein is...   108   5e-23
gi|24797153 faciogenital dysplasia protein [Homo sapiens]             103   2e-21
gi|21735572 epithelial cell transforming sequence 2 oncogene pro...   103   2e-21
gi|47578117 DEP domain containing 2 isoform b [Homo sapiens]          102   5e-21
gi|47578115 DEP domain containing 2 isoform a [Homo sapiens]          102   5e-21
gi|134133248 FYVE, RhoGEF and PH domain containing 3 [Homo sapiens]   101   7e-21
gi|134133265 FYVE, RhoGEF and PH domain containing 3 [Homo sapiens]   101   7e-21
gi|154240686 FYVE, RhoGEF and PH domain containing 6 [Homo sapiens]    99   4e-20
gi|189217917 FYVE, RhoGEF and PH domain containing 2 [Homo sapiens]    94   1e-18
gi|198041928 FYVE, RhoGEF and PH domain containing 4 [Homo sapiens]    94   2e-18
gi|58331187 T-cell lymphoma invasion and metastasis 2 isoform a ...    93   3e-18
gi|47717123 intersectin 1 isoform ITSN-l [Homo sapiens]                92   4e-18
gi|58331189 T-cell lymphoma invasion and metastasis 2 isoform b ...    92   7e-18
gi|120432044 vav 3 guanine nucleotide exchange factor isoform 1 ...    89   3e-17
gi|197304715 vav 2 guanine nucleotide exchange factor isoform 1 ...    85   6e-16
gi|40549448 vav 2 guanine nucleotide exchange factor isoform 2 [...    85   6e-16
gi|118150678 epithelial cell transforming sequence 2 oncogene-li...    81   1e-14

>gi|21361458 Rho guanine nucleotide exchange factor (GEF) 17 [Homo
            sapiens]
          Length = 2063

 Score = 4171 bits (10817), Expect = 0.0
 Identities = 2063/2063 (100%), Positives = 2063/2063 (100%)

Query: 1    MADGAPRPQLYRSVSFKLLERWSGGPGLREEDTDTPGLRRRASCRPTTAARGQPSRRVSK 60
            MADGAPRPQLYRSVSFKLLERWSGGPGLREEDTDTPGLRRRASCRPTTAARGQPSRRVSK
Sbjct: 1    MADGAPRPQLYRSVSFKLLERWSGGPGLREEDTDTPGLRRRASCRPTTAARGQPSRRVSK 60

Query: 61   LASGPLAAPAQPRPLRSLSPSVRQLSRRFDAPRLDDGSAGTRDGGVLPAAAEEAAEGPAR 120
            LASGPLAAPAQPRPLRSLSPSVRQLSRRFDAPRLDDGSAGTRDGGVLPAAAEEAAEGPAR
Sbjct: 61   LASGPLAAPAQPRPLRSLSPSVRQLSRRFDAPRLDDGSAGTRDGGVLPAAAEEAAEGPAR 120

Query: 121  GAWPSVTEMRKLFGGPGSRRPSADSESPGTPSPDGAAWEPPARESRQPPTPPPRTCFPLA 180
            GAWPSVTEMRKLFGGPGSRRPSADSESPGTPSPDGAAWEPPARESRQPPTPPPRTCFPLA
Sbjct: 121  GAWPSVTEMRKLFGGPGSRRPSADSESPGTPSPDGAAWEPPARESRQPPTPPPRTCFPLA 180

Query: 181  GLRSARPLTGPETEGRLRRPQQQQERAQRPADGLHSWHIFSQPQAGARASCSSSSIAASY 240
            GLRSARPLTGPETEGRLRRPQQQQERAQRPADGLHSWHIFSQPQAGARASCSSSSIAASY
Sbjct: 181  GLRSARPLTGPETEGRLRRPQQQQERAQRPADGLHSWHIFSQPQAGARASCSSSSIAASY 240

Query: 241  PVSRSRAASSSEEEEEGPPQLPGAQSPAYHGGHSSGSDDDRDGEGGHRWGGRPGLRPGSS 300
            PVSRSRAASSSEEEEEGPPQLPGAQSPAYHGGHSSGSDDDRDGEGGHRWGGRPGLRPGSS
Sbjct: 241  PVSRSRAASSSEEEEEGPPQLPGAQSPAYHGGHSSGSDDDRDGEGGHRWGGRPGLRPGSS 300

Query: 301  LLDQDCRPDSDGLNLSSMNSAGVSGSPEPPTSPRAPREEGLREWGSGSPPCVPGPQEGLR 360
            LLDQDCRPDSDGLNLSSMNSAGVSGSPEPPTSPRAPREEGLREWGSGSPPCVPGPQEGLR
Sbjct: 301  LLDQDCRPDSDGLNLSSMNSAGVSGSPEPPTSPRAPREEGLREWGSGSPPCVPGPQEGLR 360

Query: 361  PMSDSVGGAFRVAKVSFPSYLASPAGSRGSSRYSSTETLKDDDLWSSRGSGGWGVYRSPS 420
            PMSDSVGGAFRVAKVSFPSYLASPAGSRGSSRYSSTETLKDDDLWSSRGSGGWGVYRSPS
Sbjct: 361  PMSDSVGGAFRVAKVSFPSYLASPAGSRGSSRYSSTETLKDDDLWSSRGSGGWGVYRSPS 420

Query: 421  FGAGEGLLRSQARTRAKGPGGTSRALRDGGFEPEKSRQRKSLSNPDIASETLTLLSFLRS 480
            FGAGEGLLRSQARTRAKGPGGTSRALRDGGFEPEKSRQRKSLSNPDIASETLTLLSFLRS
Sbjct: 421  FGAGEGLLRSQARTRAKGPGGTSRALRDGGFEPEKSRQRKSLSNPDIASETLTLLSFLRS 480

Query: 481  DLSELRVRKPGGSSGDRGSNPLDGRDSPSAGGPVGQLEPIPIPAPASPGTRPTLKDLTAT 540
            DLSELRVRKPGGSSGDRGSNPLDGRDSPSAGGPVGQLEPIPIPAPASPGTRPTLKDLTAT
Sbjct: 481  DLSELRVRKPGGSSGDRGSNPLDGRDSPSAGGPVGQLEPIPIPAPASPGTRPTLKDLTAT 540

Query: 541  LRRAKSFTCSEKPMARRLPRTSALKSSSSELLLTGPGAEEDPLPLIVQDQYVQEARQVFE 600
            LRRAKSFTCSEKPMARRLPRTSALKSSSSELLLTGPGAEEDPLPLIVQDQYVQEARQVFE
Sbjct: 541  LRRAKSFTCSEKPMARRLPRTSALKSSSSELLLTGPGAEEDPLPLIVQDQYVQEARQVFE 600

Query: 601  KIQRMGAQQDDGSDAPPGSPDWAGDVTRGQRSQEELSGPESSLTDEGIGADPEPPVAAFC 660
            KIQRMGAQQDDGSDAPPGSPDWAGDVTRGQRSQEELSGPESSLTDEGIGADPEPPVAAFC
Sbjct: 601  KIQRMGAQQDDGSDAPPGSPDWAGDVTRGQRSQEELSGPESSLTDEGIGADPEPPVAAFC 660

Query: 661  GLGTTGMWRPLSSSSAQTNHHGPGTEDSLGGWALVSPETPPTPGALRRRRKVPPSGSGGS 720
            GLGTTGMWRPLSSSSAQTNHHGPGTEDSLGGWALVSPETPPTPGALRRRRKVPPSGSGGS
Sbjct: 661  GLGTTGMWRPLSSSSAQTNHHGPGTEDSLGGWALVSPETPPTPGALRRRRKVPPSGSGGS 720

Query: 721  ELSNGEAGEAYRSLSDPIPQRHRAATSEEPTGFSVDSNLLGSLSPKTGLPATSAMDEGLT 780
            ELSNGEAGEAYRSLSDPIPQRHRAATSEEPTGFSVDSNLLGSLSPKTGLPATSAMDEGLT
Sbjct: 721  ELSNGEAGEAYRSLSDPIPQRHRAATSEEPTGFSVDSNLLGSLSPKTGLPATSAMDEGLT 780

Query: 781  SGHSDWSVGSEESKGYQEVIQSIVQGPGTLGRVVDDRIAGKAPKKKSLSDPSRRGELAGP 840
            SGHSDWSVGSEESKGYQEVIQSIVQGPGTLGRVVDDRIAGKAPKKKSLSDPSRRGELAGP
Sbjct: 781  SGHSDWSVGSEESKGYQEVIQSIVQGPGTLGRVVDDRIAGKAPKKKSLSDPSRRGELAGP 840

Query: 841  GFEGPGGEPIREVEPMLPPSSSEPILVEQRAEPEEPGATRSRAQSERALPEALPPPATAH 900
            GFEGPGGEPIREVEPMLPPSSSEPILVEQRAEPEEPGATRSRAQSERALPEALPPPATAH
Sbjct: 841  GFEGPGGEPIREVEPMLPPSSSEPILVEQRAEPEEPGATRSRAQSERALPEALPPPATAH 900

Query: 901  RNFHLDPKLADILSPRLIRRGSKKRPARSSHQELRRDEGSQDQTGSLSRARPSSRHVRHA 960
            RNFHLDPKLADILSPRLIRRGSKKRPARSSHQELRRDEGSQDQTGSLSRARPSSRHVRHA
Sbjct: 901  RNFHLDPKLADILSPRLIRRGSKKRPARSSHQELRRDEGSQDQTGSLSRARPSSRHVRHA 960

Query: 961  SVPATFMPIVVPEPPTSVGPPVAVPEPIGFPTRAHPTLQAPSLEDVTKQYMLNLHSGEVP 1020
            SVPATFMPIVVPEPPTSVGPPVAVPEPIGFPTRAHPTLQAPSLEDVTKQYMLNLHSGEVP
Sbjct: 961  SVPATFMPIVVPEPPTSVGPPVAVPEPIGFPTRAHPTLQAPSLEDVTKQYMLNLHSGEVP 1020

Query: 1021 APVPVDMPCLPLAAPPSAEAKPPEAARPADEPTPASKCCSKPQVDMRKHVAMTLLDTEQS 1080
            APVPVDMPCLPLAAPPSAEAKPPEAARPADEPTPASKCCSKPQVDMRKHVAMTLLDTEQS
Sbjct: 1021 APVPVDMPCLPLAAPPSAEAKPPEAARPADEPTPASKCCSKPQVDMRKHVAMTLLDTEQS 1080

Query: 1081 YVESLRTLMQGYMQPLKQPENSVLCDPSLVDEIFDQIPELLEHHEQFLEQVRHCMQTWHA 1140
            YVESLRTLMQGYMQPLKQPENSVLCDPSLVDEIFDQIPELLEHHEQFLEQVRHCMQTWHA
Sbjct: 1081 YVESLRTLMQGYMQPLKQPENSVLCDPSLVDEIFDQIPELLEHHEQFLEQVRHCMQTWHA 1140

Query: 1141 QQKVGALLVQSFSKDVLVNIYSAYIDNFLNAKDAVRVAKEARPAFLKFLEQSMRENKEKQ 1200
            QQKVGALLVQSFSKDVLVNIYSAYIDNFLNAKDAVRVAKEARPAFLKFLEQSMRENKEKQ
Sbjct: 1141 QQKVGALLVQSFSKDVLVNIYSAYIDNFLNAKDAVRVAKEARPAFLKFLEQSMRENKEKQ 1200

Query: 1201 ALSDLMIKPVQRIPRYELLVKDLLKHTPEDHPDHPLLLEAQRNIKQVAERINKGVRSAEE 1260
            ALSDLMIKPVQRIPRYELLVKDLLKHTPEDHPDHPLLLEAQRNIKQVAERINKGVRSAEE
Sbjct: 1201 ALSDLMIKPVQRIPRYELLVKDLLKHTPEDHPDHPLLLEAQRNIKQVAERINKGVRSAEE 1260

Query: 1261 AERHARVLQEIEAHIEGMEDLQAPLRRFLRQEMVIEVKAIGGKKDRSLFLFTDLIVCTTL 1320
            AERHARVLQEIEAHIEGMEDLQAPLRRFLRQEMVIEVKAIGGKKDRSLFLFTDLIVCTTL
Sbjct: 1261 AERHARVLQEIEAHIEGMEDLQAPLRRFLRQEMVIEVKAIGGKKDRSLFLFTDLIVCTTL 1320

Query: 1321 KRKSGSLRRSSMSLYTAASVIDTASKYKMLWKLPLEDADIIKGASQATNRENIQKAISRL 1380
            KRKSGSLRRSSMSLYTAASVIDTASKYKMLWKLPLEDADIIKGASQATNRENIQKAISRL
Sbjct: 1321 KRKSGSLRRSSMSLYTAASVIDTASKYKMLWKLPLEDADIIKGASQATNRENIQKAISRL 1380

Query: 1381 DEDLTTLGQMSKLSESLGFPHQSLDDALRDLSAAMHRDLSEKQALCYALSFPPTKLELCA 1440
            DEDLTTLGQMSKLSESLGFPHQSLDDALRDLSAAMHRDLSEKQALCYALSFPPTKLELCA
Sbjct: 1381 DEDLTTLGQMSKLSESLGFPHQSLDDALRDLSAAMHRDLSEKQALCYALSFPPTKLELCA 1440

Query: 1441 TRPEGTDSYIFEFPHPDARLGFEQAFDEAKRKLASSKSCLDPEFLKAIPIMKTRSGMQFS 1500
            TRPEGTDSYIFEFPHPDARLGFEQAFDEAKRKLASSKSCLDPEFLKAIPIMKTRSGMQFS
Sbjct: 1441 TRPEGTDSYIFEFPHPDARLGFEQAFDEAKRKLASSKSCLDPEFLKAIPIMKTRSGMQFS 1500

Query: 1501 CAAPTLNSCPEPSPEVWVCNSDGYVGQVCLLSLRAEPDVEACIAVCSARILCIGAVPGLQ 1560
            CAAPTLNSCPEPSPEVWVCNSDGYVGQVCLLSLRAEPDVEACIAVCSARILCIGAVPGLQ
Sbjct: 1501 CAAPTLNSCPEPSPEVWVCNSDGYVGQVCLLSLRAEPDVEACIAVCSARILCIGAVPGLQ 1560

Query: 1561 PRCHREPPPSLRSPPETAPEPAGPELDVEAAADEEAATLAEPGPQPCLHISIAGSGLEMT 1620
            PRCHREPPPSLRSPPETAPEPAGPELDVEAAADEEAATLAEPGPQPCLHISIAGSGLEMT
Sbjct: 1561 PRCHREPPPSLRSPPETAPEPAGPELDVEAAADEEAATLAEPGPQPCLHISIAGSGLEMT 1620

Query: 1621 PGLGEGDPRPELVPFDSDSDDESSPSPSGTLQSQASRSTISSSFGNEETPSSKEATAETT 1680
            PGLGEGDPRPELVPFDSDSDDESSPSPSGTLQSQASRSTISSSFGNEETPSSKEATAETT
Sbjct: 1621 PGLGEGDPRPELVPFDSDSDDESSPSPSGTLQSQASRSTISSSFGNEETPSSKEATAETT 1680

Query: 1681 SSEEEQEPGFLPLSGSFGPGGPCGTSPMDGRALRRSSHGSFTRGSLEDLLSVDPEAYQSS 1740
            SSEEEQEPGFLPLSGSFGPGGPCGTSPMDGRALRRSSHGSFTRGSLEDLLSVDPEAYQSS
Sbjct: 1681 SSEEEQEPGFLPLSGSFGPGGPCGTSPMDGRALRRSSHGSFTRGSLEDLLSVDPEAYQSS 1740

Query: 1741 VWLGTEDGCVHVYQSSDSIRDRRNSMKLQHAASVTCILYLNNQVFVSLANGELVVYQREA 1800
            VWLGTEDGCVHVYQSSDSIRDRRNSMKLQHAASVTCILYLNNQVFVSLANGELVVYQREA
Sbjct: 1741 VWLGTEDGCVHVYQSSDSIRDRRNSMKLQHAASVTCILYLNNQVFVSLANGELVVYQREA 1800

Query: 1801 GHFWDPQNFKSVTLGTQGSPITKMVSVGGRLWCGCQNRVLVLSPDTLQLEHMFYVGQDSS 1860
            GHFWDPQNFKSVTLGTQGSPITKMVSVGGRLWCGCQNRVLVLSPDTLQLEHMFYVGQDSS
Sbjct: 1801 GHFWDPQNFKSVTLGTQGSPITKMVSVGGRLWCGCQNRVLVLSPDTLQLEHMFYVGQDSS 1860

Query: 1861 RCVACMVDSSLGVWVTLKGSAHVCLYHPDTFEQLAEVDVTPPVHRMLAGSDAIIRQHKAA 1920
            RCVACMVDSSLGVWVTLKGSAHVCLYHPDTFEQLAEVDVTPPVHRMLAGSDAIIRQHKAA
Sbjct: 1861 RCVACMVDSSLGVWVTLKGSAHVCLYHPDTFEQLAEVDVTPPVHRMLAGSDAIIRQHKAA 1920

Query: 1921 CLRITALLVCEELLWVGTSAGVVLTMPTSPGTVSCPRAPLSPTGLGQGHTGHVRFLAAVQ 1980
            CLRITALLVCEELLWVGTSAGVVLTMPTSPGTVSCPRAPLSPTGLGQGHTGHVRFLAAVQ
Sbjct: 1921 CLRITALLVCEELLWVGTSAGVVLTMPTSPGTVSCPRAPLSPTGLGQGHTGHVRFLAAVQ 1980

Query: 1981 LPDGFNLLCPTPPPPPDTGPEKLPSLEHRDSPWHRGPAPARPKMLVISGGDGYEDFRLSS 2040
            LPDGFNLLCPTPPPPPDTGPEKLPSLEHRDSPWHRGPAPARPKMLVISGGDGYEDFRLSS
Sbjct: 1981 LPDGFNLLCPTPPPPPDTGPEKLPSLEHRDSPWHRGPAPARPKMLVISGGDGYEDFRLSS 2040

Query: 2041 GGGSSSETVGRDDSTNHLLLWRV 2063
            GGGSSSETVGRDDSTNHLLLWRV
Sbjct: 2041 GGGSSSETVGRDDSTNHLLLWRV 2063


>gi|62548864 Rho guanine nucleotide exchange factor 10 [Homo sapiens]
          Length = 1344

 Score =  166 bits (421), Expect = 2e-40
 Identities = 146/609 (23%), Positives = 288/609 (47%), Gaps = 88/609 (14%)

Query: 1039 EAKPPEAARPADEPTPASKCCSKPQVDMRKHVAMTLLDTEQSYVESLRTLMQGYMQPLKQ 1098
            + K PEA       TP  +  S+ QV +R+++  +++D+E++YV++L+ +++ Y +PL +
Sbjct: 375  DCKHPEAIL-----TPMPEGLSQQQV-VRRYILGSVVDSEKNYVDALKRILEQYEKPLSE 428

Query: 1099 PENSVLCDPSLVDEIFDQIPELLEHHEQFLEQVRHCMQTWHAQQKVGALLVQSFSKDVLV 1158
             E  VL +  L   +F ++ E+L+ H  F   +   +  W + + +G + V SFSK +++
Sbjct: 429  MEPKVLSERKL-KTVFYRVKEILQCHSLFQIALASRVSEWDSVEMIGDVFVASFSKSMVL 487

Query: 1159 NIYSAYIDNFLNAKDAVRVAKEARPAFLKFLEQSMRENKEKQALSDLMIKPVQRIPRYEL 1218
            + YS Y++NF  A   ++     +PAFL+FL+Q    + ++  L  LM+KP+QR P++ L
Sbjct: 488  DAYSEYVNNFSTAVAVLKKTCATKPAFLEFLKQEQEASPDRTTLYSLMMKPIQRFPQFIL 547

Query: 1219 LVKDLLKHTPEDHPDHPLLLEAQRNIKQVAERINKGVRSAEEAERHARVLQEI-EAHIEG 1277
            L++D+LK+T + HPD   L  A   ++ +AE++N+  R A++     ++ + I E ++  
Sbjct: 548  LLQDMLKNTSKGHPDRLPLQMALTELETLAEKLNERKRDADQRCEVKQIAKAINERYLNK 607

Query: 1278 MEDLQAPLRRFLRQEMVIEV-----KAIGGKKDRSLFLFTDLIVCTTLKRKSGSLRRSSM 1332
            +  L +  R  +R + +IE        I   K+R +F+  D+++C T+  +     R   
Sbjct: 608  L--LSSGSRYLIRSDDMIETVYNDRGEIVKTKERRVFMLNDVLMCATVSSRPSHDSR--- 662

Query: 1333 SLYTAASVIDTASKYKMLWKLPLEDADIIKGASQATNREN-------------------- 1372
                    + ++ +Y + W +PL   D I+  S A   E+                    
Sbjct: 663  --------VMSSQRYLLKWSVPLGHVDAIEYGSSAGTGEHSRHLAVHPPESLAVVANAKP 714

Query: 1373 ---------IQKAISRLDEDLTTLGQMSKLSESLGFPHQSLDDAL-RDLSAAMHRDLSEK 1422
                     + + +  L  DL  +GQ+++L  +L   +Q+L+ ++  D ++ + R + +K
Sbjct: 715  NKVYMGPGQLYQDLQNLLHDLNVIGQITQLIGNLKGNYQNLNQSVAHDWTSGLQRLILKK 774

Query: 1423 QALCYALSFPPTKLELCATRPE-GTDSY---IFEFPHPDARLGFEQAFDEAKRKLASSKS 1478
            +    A      +L+L   + + G  ++   +F    P  +  +  +   AK  L     
Sbjct: 775  EDEIRAADCCRIQLQLPGKQDKSGRPTFFTAVFNTFTPAIKESWVNSLQMAKLALEEENH 834

Query: 1479 ----CLD-----------PEFLKAIPIMKTR-SGMQFSCAA----PTLNSCPEPSP---- 1514
                C++           P  +  +P+M  +    +  CAA    P LN+  +P      
Sbjct: 835  MGWFCVEDDGNHIKKEKHPLLVGHMPVMVAKQQEFKIECAAYNPEPYLNNESQPDSFSTA 894

Query: 1515 --EVWVCNSDGYVGQVCLLSLR-AEPDVEACIAVCSARILCIGAVPGLQPRCHREPPPSL 1571
               +W+ +    +GQ+ ++S + + P V  C  V  +RILC+  VP  + R     PP  
Sbjct: 895  HGFLWIGSCTHQMGQIAIVSFQNSTPKVIECFNV-ESRILCMLYVPVEEKRREPGAPPDP 953

Query: 1572 RSPPETAPE 1580
             +P   A +
Sbjct: 954  ETPAVRASD 962



 Score =  110 bits (274), Expect = 2e-23
 Identities = 75/283 (26%), Positives = 130/283 (45%), Gaps = 39/283 (13%)

Query: 1740 SVWLGTEDGCVHVYQSSDSIRDRRNSMKLQH-----AASVTCILYLNNQVFVSLANGELV 1794
            ++ +GTE+G + +Y+SS   +     ++LQH      ++V  +   +  ++  L NG + 
Sbjct: 965  TICVGTEEGSISIYKSSQGSK----KVRLQHFFTPEKSTVMSLACTSQSLYAGLVNGAVA 1020

Query: 1795 VYQREAGHFWDPQNFKSVTLGTQGSPITKMVSVGGRLWCGCQNRVLVLSPDTLQLEHMFY 1854
             Y R     WD +  K + LG    P+  ++ +   LW     +V ++S +T  +E    
Sbjct: 1021 SYARAPDGSWDSEPQKVIKLGVL--PVRSLLMMEDTLWAASGGQVFIISVETHAVEGQLE 1078

Query: 1855 VGQDSSRCVACMVDSSLGVWVTLKGSAHVCLYHPDTFEQLAEVDVTPPVHRMLAGSDAII 1914
              Q+    ++ M  S +G+W+     + + L+H +T + L ++++  PVH ML G     
Sbjct: 1079 AHQEEGMVISHMAVSGVGIWIAFTSGSTLRLFHTETLKHLQDINIATPVHNMLPGHQR-- 1136

Query: 1915 RQHKAACLRITALLVCEELLWVGTSAGVVLTMPTSPGTVSCPRAPLSPTGLGQG------ 1968
                   L +T+LLVC  LL VGTS GV++ +P        PR    P   G+G      
Sbjct: 1137 -------LSVTSLLVCHGLLMVGTSLGVLVALPV-------PRLQGIPKVTGRGMVSYHA 1182

Query: 1969 HTGHVRFLA-AVQLPD-----GFNLLCPTPPPPPDTGPEKLPS 2005
            H   V+F+  A  L +       + L P P P  +   + LPS
Sbjct: 1183 HNSPVKFIVLATALHEKDKDKSRDSLAPGPEPQDEDQKDALPS 1225


>gi|58761492 Rho guanine nucleotide exchange factor (GEF) 10-like
            isoform 1 [Homo sapiens]
          Length = 1279

 Score =  162 bits (410), Expect = 3e-39
 Identities = 146/602 (24%), Positives = 269/602 (44%), Gaps = 83/602 (13%)

Query: 1048 PADEPTPASKCCSKPQVDMRKHVAMTLLDTEQSYVESLRTLMQGYMQPLKQPENSVLCDP 1107
            PA E  P  +  S  QV +R+H+  +++ +E SYVESL+ ++Q Y  PL + E   L   
Sbjct: 299  PAPELGPMPEGLSPQQV-VRRHILGSIVQSEGSYVESLKRILQDYRNPLMEMEPKAL-SA 356

Query: 1108 SLVDEIFDQIPELLEHHEQFLEQVRHCMQTWHAQQKVGALLVQSFSKDVLVNIYSAYIDN 1167
                 +F ++ E+L  H  F   +   +  W + +K+G L V SFSK +++++YS Y++N
Sbjct: 357  RKCQVVFFRVKEILHCHSMFQIALSSRVAEWDSTEKIGDLFVASFSKSMVLDVYSDYVNN 416

Query: 1168 FLNAKDAVRVAKEARPAFLKFLEQSMRENKEKQALSDLMIKPVQRIPRYELLVKDLLKHT 1227
            F +A   ++ A   +PAFL+FL++    + ++  L  LM+KP+QR P++ LL++D+LK+T
Sbjct: 417  FTSAMSIIKKACLTKPAFLEFLKRRQVCSPDRVTLYGLMVKPIQRFPQFILLLQDMLKNT 476

Query: 1228 PEDHPDHPLLLEAQRNIKQVAERINKGVRSAEEAERHARVLQEIEAHIEGMEDLQAPLRR 1287
            P  HPD   L  A   ++ +AE++N+  R A++       +Q++   +     L   L  
Sbjct: 477  PRGHPDRLSLQLALTELETLAEKLNEQKRLADQVAE----IQQLTKSVSDRSSLNKLLTS 532

Query: 1288 FLRQEMVIE--VKAIGG-------KKDRSLFLFTDLIVCTTLKRKSGSLRRSSMSLYTAA 1338
              RQ ++ E   + + G        K+R +FL  D++VC  +  K  +  R  + +   +
Sbjct: 533  GQRQLLLCETLTETVYGDRGQLIKSKERRVFLLNDMLVCANINFKPAN-HRGQLEI---S 588

Query: 1339 SVIDTASKYKMLWKLPLEDADIIK------------------------GASQATNR---- 1370
            S++    KY + W   L    +++                         + QA N+    
Sbjct: 589  SLVPLGPKYVVKWNTALPQVQVVEVGQDGGTYDKDNVLIQHSGAKKASASGQAQNKVYLG 648

Query: 1371 -ENIQKAISRLDEDLTTLGQMSKLSESLGFPHQSLD-DALRDLSAAMHRDLSEKQALCYA 1428
               + + +  L +DL  + Q++ L  +L   +Q+L+    +D   A+ R +  K+   ++
Sbjct: 649  PPRLFQELQDLQKDLAVVEQITLLISTLHGTYQNLNMTVAQDWCLALQRLMRVKEEEIHS 708

Query: 1429 LSFPPTKLELCATRPEGTD-----SYIFEFPHPDARLGFEQAFDEAKRKLASSKS----C 1479
             +    +L L   +P+ +        +F  P+P +++ +      AK  L         C
Sbjct: 709  ANKCRLRL-LLPGKPDKSGRPISFMVVFITPNPLSKISWVNRLHLAKIGLREENQPGWLC 767

Query: 1480 LD-----------PEFLKAIPIMKTRS-GMQFSCAAPTLNSCP----------EPSPEVW 1517
             D           P     IP   +R+  +Q      +  +CP           P   +W
Sbjct: 768  PDEDKKSKAPFWCPILACCIPAFSSRALSLQLGALVHSPVNCPLLGFSAVSTSLPQGYLW 827

Query: 1518 V-CNSDGYVGQVCLLSLRAEPDVEACIAVCSARILCIGAVPGLQPRCH-REPPPSLRSPP 1575
            V    +G  GQV + SL             +A +LC+  +P L+     R+  P++  P 
Sbjct: 828  VGGGQEGAGGQVEIFSLNRPSPRTVKSFPLAAPVLCMEYIPELEEEAESRDESPTVADPS 887

Query: 1576 ET 1577
             T
Sbjct: 888  AT 889



 Score =  114 bits (285), Expect = 1e-24
 Identities = 112/411 (27%), Positives = 159/411 (38%), Gaps = 100/411 (24%)

Query: 1733 DPEA-YQSSVWLGTEDGCVHVYQSSDSIRDRRNSMKLQHAASVTCILYLNNQVFVSLANG 1791
            DP A    ++ LG +DG + +Y S D+      S +      V C+ +    +   L +G
Sbjct: 885  DPSATVHPTICLGLQDGSILLYSSVDTGTQCLVSCRSPGLQPVLCLRHSPFHLLAGLQDG 944

Query: 1792 ELVVYQREAGH-FWDPQNFKSVTLGTQGSPITKMVSVGGRLWCGCQNRVLVLSPDTLQLE 1850
             L  Y R +G   WD ++   V L     P+  ++S+   +W  C  RV VL   TLQ +
Sbjct: 945  TLAAYPRTSGGVLWDLES-PPVCLTVGPGPVRTLLSLEDAVWASCGPRVTVLEATTLQPQ 1003

Query: 1851 HMFYVGQDSSRCVACMVDSSLGVWVTLKGSAHVCLYHPDTFEQLAEVDVTPPVHRMLAGS 1910
              F   QD +  V  MV +  GVW+       + L+H +T E L E+++      +L G 
Sbjct: 1004 QSFEAHQDEAVSVTHMVKAGSGVWMAFSSGTSIRLFHTETLEHLQEINIATRTTFLLPG- 1062

Query: 1911 DAIIRQHKAACLRITALLVCEELLWVGTSAGVVLTMPTSPGTVSCPRAPLSPTGLG---- 1966
                ++H    L +T+LL+C+ LLWVGT  GV++ +P  P     P+     TG G    
Sbjct: 1063 ----QKH----LCVTSLLICQGLLWVGTDQGVIVLLPV-PRLEGIPKI----TGKGMVSL 1109

Query: 1967 QGHTGHVRFLAAV-----------------------QLPDGFNLLCPTPPPPPDTGPE-- 2001
             GH G V FLA                           PDG       P P    G E  
Sbjct: 1110 NGHCGPVAFLAVATSILAPDILRSDQEEAEGPRAEEDKPDG---QAHEPMPDSHVGRELT 1166

Query: 2002 ---------KLPSLEHRDSPW--HRGPAPA---------------------------RP- 2022
                     +L S  H   P    R PAPA                           RP 
Sbjct: 1167 RKKGILLQYRLRSTAHLPGPLLSMREPAPADGAALEHSEEDGSIYEMADDPDIWVRSRPC 1226

Query: 2023 ----------KMLVISGGDGYEDFRLSSGGGSSSETVGRDDSTNHLLLWRV 2063
                       + +ISGG GY +F  + G        G  DST  LL+W+V
Sbjct: 1227 ARDAHRKEICSVAIISGGQGYRNFGSALGSSGRQAPCGETDST--LLIWQV 1275


>gi|74136547 Rho guanine nucleotide exchange factor (GEF) 10-like
            isoform 2 [Homo sapiens]
          Length = 1240

 Score =  162 bits (410), Expect = 3e-39
 Identities = 146/602 (24%), Positives = 269/602 (44%), Gaps = 83/602 (13%)

Query: 1048 PADEPTPASKCCSKPQVDMRKHVAMTLLDTEQSYVESLRTLMQGYMQPLKQPENSVLCDP 1107
            PA E  P  +  S  QV +R+H+  +++ +E SYVESL+ ++Q Y  PL + E   L   
Sbjct: 260  PAPELGPMPEGLSPQQV-VRRHILGSIVQSEGSYVESLKRILQDYRNPLMEMEPKAL-SA 317

Query: 1108 SLVDEIFDQIPELLEHHEQFLEQVRHCMQTWHAQQKVGALLVQSFSKDVLVNIYSAYIDN 1167
                 +F ++ E+L  H  F   +   +  W + +K+G L V SFSK +++++YS Y++N
Sbjct: 318  RKCQVVFFRVKEILHCHSMFQIALSSRVAEWDSTEKIGDLFVASFSKSMVLDVYSDYVNN 377

Query: 1168 FLNAKDAVRVAKEARPAFLKFLEQSMRENKEKQALSDLMIKPVQRIPRYELLVKDLLKHT 1227
            F +A   ++ A   +PAFL+FL++    + ++  L  LM+KP+QR P++ LL++D+LK+T
Sbjct: 378  FTSAMSIIKKACLTKPAFLEFLKRRQVCSPDRVTLYGLMVKPIQRFPQFILLLQDMLKNT 437

Query: 1228 PEDHPDHPLLLEAQRNIKQVAERINKGVRSAEEAERHARVLQEIEAHIEGMEDLQAPLRR 1287
            P  HPD   L  A   ++ +AE++N+  R A++       +Q++   +     L   L  
Sbjct: 438  PRGHPDRLSLQLALTELETLAEKLNEQKRLADQVAE----IQQLTKSVSDRSSLNKLLTS 493

Query: 1288 FLRQEMVIE--VKAIGG-------KKDRSLFLFTDLIVCTTLKRKSGSLRRSSMSLYTAA 1338
              RQ ++ E   + + G        K+R +FL  D++VC  +  K  +  R  + +   +
Sbjct: 494  GQRQLLLCETLTETVYGDRGQLIKSKERRVFLLNDMLVCANINFKPAN-HRGQLEI---S 549

Query: 1339 SVIDTASKYKMLWKLPLEDADIIK------------------------GASQATNR---- 1370
            S++    KY + W   L    +++                         + QA N+    
Sbjct: 550  SLVPLGPKYVVKWNTALPQVQVVEVGQDGGTYDKDNVLIQHSGAKKASASGQAQNKVYLG 609

Query: 1371 -ENIQKAISRLDEDLTTLGQMSKLSESLGFPHQSLD-DALRDLSAAMHRDLSEKQALCYA 1428
               + + +  L +DL  + Q++ L  +L   +Q+L+    +D   A+ R +  K+   ++
Sbjct: 610  PPRLFQELQDLQKDLAVVEQITLLISTLHGTYQNLNMTVAQDWCLALQRLMRVKEEEIHS 669

Query: 1429 LSFPPTKLELCATRPEGTD-----SYIFEFPHPDARLGFEQAFDEAKRKLASSKS----C 1479
             +    +L L   +P+ +        +F  P+P +++ +      AK  L         C
Sbjct: 670  ANKCRLRL-LLPGKPDKSGRPISFMVVFITPNPLSKISWVNRLHLAKIGLREENQPGWLC 728

Query: 1480 LD-----------PEFLKAIPIMKTRS-GMQFSCAAPTLNSCP----------EPSPEVW 1517
             D           P     IP   +R+  +Q      +  +CP           P   +W
Sbjct: 729  PDEDKKSKAPFWCPILACCIPAFSSRALSLQLGALVHSPVNCPLLGFSAVSTSLPQGYLW 788

Query: 1518 V-CNSDGYVGQVCLLSLRAEPDVEACIAVCSARILCIGAVPGLQPRCH-REPPPSLRSPP 1575
            V    +G  GQV + SL             +A +LC+  +P L+     R+  P++  P 
Sbjct: 789  VGGGQEGAGGQVEIFSLNRPSPRTVKSFPLAAPVLCMEYIPELEEEAESRDESPTVADPS 848

Query: 1576 ET 1577
             T
Sbjct: 849  AT 850



 Score =  114 bits (285), Expect = 1e-24
 Identities = 112/411 (27%), Positives = 159/411 (38%), Gaps = 100/411 (24%)

Query: 1733 DPEA-YQSSVWLGTEDGCVHVYQSSDSIRDRRNSMKLQHAASVTCILYLNNQVFVSLANG 1791
            DP A    ++ LG +DG + +Y S D+      S +      V C+ +    +   L +G
Sbjct: 846  DPSATVHPTICLGLQDGSILLYSSVDTGTQCLVSCRSPGLQPVLCLRHSPFHLLAGLQDG 905

Query: 1792 ELVVYQREAGH-FWDPQNFKSVTLGTQGSPITKMVSVGGRLWCGCQNRVLVLSPDTLQLE 1850
             L  Y R +G   WD ++   V L     P+  ++S+   +W  C  RV VL   TLQ +
Sbjct: 906  TLAAYPRTSGGVLWDLES-PPVCLTVGPGPVRTLLSLEDAVWASCGPRVTVLEATTLQPQ 964

Query: 1851 HMFYVGQDSSRCVACMVDSSLGVWVTLKGSAHVCLYHPDTFEQLAEVDVTPPVHRMLAGS 1910
              F   QD +  V  MV +  GVW+       + L+H +T E L E+++      +L G 
Sbjct: 965  QSFEAHQDEAVSVTHMVKAGSGVWMAFSSGTSIRLFHTETLEHLQEINIATRTTFLLPG- 1023

Query: 1911 DAIIRQHKAACLRITALLVCEELLWVGTSAGVVLTMPTSPGTVSCPRAPLSPTGLG---- 1966
                ++H    L +T+LL+C+ LLWVGT  GV++ +P  P     P+     TG G    
Sbjct: 1024 ----QKH----LCVTSLLICQGLLWVGTDQGVIVLLPV-PRLEGIPKI----TGKGMVSL 1070

Query: 1967 QGHTGHVRFLAAV-----------------------QLPDGFNLLCPTPPPPPDTGPE-- 2001
             GH G V FLA                           PDG       P P    G E  
Sbjct: 1071 NGHCGPVAFLAVATSILAPDILRSDQEEAEGPRAEEDKPDG---QAHEPMPDSHVGRELT 1127

Query: 2002 ---------KLPSLEHRDSPW--HRGPAPA---------------------------RP- 2022
                     +L S  H   P    R PAPA                           RP 
Sbjct: 1128 RKKGILLQYRLRSTAHLPGPLLSMREPAPADGAALEHSEEDGSIYEMADDPDIWVRSRPC 1187

Query: 2023 ----------KMLVISGGDGYEDFRLSSGGGSSSETVGRDDSTNHLLLWRV 2063
                       + +ISGG GY +F  + G        G  DST  LL+W+V
Sbjct: 1188 ARDAHRKEICSVAIISGGQGYRNFGSALGSSGRQAPCGETDST--LLIWQV 1236


>gi|194578923 sperm associated antigen 9 isoform 1 [Homo sapiens]
          Length = 1321

 Score =  156 bits (394), Expect = 2e-37
 Identities = 158/616 (25%), Positives = 259/616 (42%), Gaps = 105/616 (17%)

Query: 1506 LNSCPEPSPEVWVCNSDGYVGQVCLLSLRAEPDVEACIAVCSARILCIGAVPGLQPRCHR 1565
            L +  E S  VW+C S     +V ++      ++     VC++ +LCI +VPG +   + 
Sbjct: 748  LKNQEELSSLVWICTSTHSATKVLIIDAVQPGNILDSFTVCNSHVLCIASVPGARETDY- 806

Query: 1566 EPPPSLRSPPETAPEPAGPELDVEAAADEEAATLAEPGPQPCLHISIAGSGLEMTPGLGE 1625
                           PAG +L      D+ +   +          S+ G G+ +     E
Sbjct: 807  ---------------PAGEDLSESGQVDKASLCGSMTSNSSAETDSLLG-GITVVGCSAE 850

Query: 1626 GDPRPELVPFDSDSDDESSPSPSGTLQSQASRSTISSSFGNEETPSSKEATAETTSSEEE 1685
            G       P    S + +SP      + +A  S +     +E  P+++EAT  T  +   
Sbjct: 851  GVTGAATSP----STNGASPVMDKPPEMEAENSEV-----DENVPTAEEATEATEGNAGS 901

Query: 1686 QEPGF-LPLSGSFGPG---GPCGTS-PMDGRALRRSSHGSFTRGSLEDLLSVDP------ 1734
             E    +  +G +       P G   P D   + +SS+ S    + +D +SV P      
Sbjct: 902  AEDTVDISQTGVYTEHVFTDPLGVQIPEDLSPVYQSSNDS---DAYKDQISVLPNEQDLV 958

Query: 1735 --EAYQSS-----VWLGTEDGCVHVYQSSDSIRDRRNSMKLQHAASVTCILYLNNQVFVS 1787
              EA + S     +WLG ++GC++V+ S    R   +S+KL+   S+  I+++   V V+
Sbjct: 959  REEAQKMSSLLPTMWLGAQNGCLYVHSSVAQWRKCLHSIKLKD--SILSIVHVKGIVLVA 1016

Query: 1788 LANGELVVYQREAGHFWDPQNFKSVTLGTQGSPITKMVSVGGRLWCGCQNRVLVLSPDTL 1847
            LA+G L ++ R     WD  N+  + LG     I  M  V  ++WCG +N++ V+ P  +
Sbjct: 1017 LADGTLAIFHRGVDGQWDLSNYHLLDLGRPHHSIRCMTVVHDKVWCGYRNKIYVVQPKAM 1076

Query: 1848 QLEHMFYVGQDSSRCVACMVDSSLGVWVTLKGSAHVCLYHPDTFEQLAEVDVTPPVHRML 1907
            ++E  F         V  +     GVWV+++  + + LYH  T++ L +VD+ P V +ML
Sbjct: 1077 KIEKSFDAHPRKESQVRQLAWVGDGVWVSIRLDSTLRLYHAHTYQHLQDVDIEPYVSKML 1136

Query: 1908 AGSDAIIRQHKAACLRITALLVCEELLWVGTSAGVVLTMPTS------------PGTVS- 1954
                        + +RITAL+V    LWVGT  GV++++P +            PG+V  
Sbjct: 1137 GTGKLGF-----SFVRITALMVSCNRLWVGTGNGVIISIPLTETNKTSGVPGNRPGSVIR 1191

Query: 1955 ---------------CPRAPLSPTGLG-QGHTGHVRFLAAVQLPDGFNLLCPTPPPPPDT 1998
                            P   ++   L   GH   V+F  AV          P     P +
Sbjct: 1192 VYGDENSDKVTPGTFIPYCSMAHAQLCFHGHRDAVKFFVAV----------PGQVISPQS 1241

Query: 1999 GPEKLPSLEHRDSPWHRGPAPARP--KMLVISGGDGYEDFRLSSGGGSSSETVGRD---- 2052
                      +  P  + P    P   MLVISGG+GY DFR+   GG  SE +G D    
Sbjct: 1242 SSSGTDLTGDKAGPSAQEPGSQTPLKSMLVISGGEGYIDFRMGDEGG-ESELLGEDLPLE 1300

Query: 2053 -----DSTNHLLLWRV 2063
                    +HL++W+V
Sbjct: 1301 PSVTKAERSHLIVWQV 1316


>gi|27436920 sperm associated antigen 9 isoform 3 [Homo sapiens]
          Length = 1307

 Score =  156 bits (394), Expect = 2e-37
 Identities = 158/616 (25%), Positives = 259/616 (42%), Gaps = 105/616 (17%)

Query: 1506 LNSCPEPSPEVWVCNSDGYVGQVCLLSLRAEPDVEACIAVCSARILCIGAVPGLQPRCHR 1565
            L +  E S  VW+C S     +V ++      ++     VC++ +LCI +VPG +   + 
Sbjct: 734  LKNQEELSSLVWICTSTHSATKVLIIDAVQPGNILDSFTVCNSHVLCIASVPGARETDY- 792

Query: 1566 EPPPSLRSPPETAPEPAGPELDVEAAADEEAATLAEPGPQPCLHISIAGSGLEMTPGLGE 1625
                           PAG +L      D+ +   +          S+ G G+ +     E
Sbjct: 793  ---------------PAGEDLSESGQVDKASLCGSMTSNSSAETDSLLG-GITVVGCSAE 836

Query: 1626 GDPRPELVPFDSDSDDESSPSPSGTLQSQASRSTISSSFGNEETPSSKEATAETTSSEEE 1685
            G       P    S + +SP      + +A  S +     +E  P+++EAT  T  +   
Sbjct: 837  GVTGAATSP----STNGASPVMDKPPEMEAENSEV-----DENVPTAEEATEATEGNAGS 887

Query: 1686 QEPGF-LPLSGSFGPG---GPCGTS-PMDGRALRRSSHGSFTRGSLEDLLSVDP------ 1734
             E    +  +G +       P G   P D   + +SS+ S    + +D +SV P      
Sbjct: 888  AEDTVDISQTGVYTEHVFTDPLGVQIPEDLSPVYQSSNDS---DAYKDQISVLPNEQDLV 944

Query: 1735 --EAYQSS-----VWLGTEDGCVHVYQSSDSIRDRRNSMKLQHAASVTCILYLNNQVFVS 1787
              EA + S     +WLG ++GC++V+ S    R   +S+KL+   S+  I+++   V V+
Sbjct: 945  REEAQKMSSLLPTMWLGAQNGCLYVHSSVAQWRKCLHSIKLKD--SILSIVHVKGIVLVA 1002

Query: 1788 LANGELVVYQREAGHFWDPQNFKSVTLGTQGSPITKMVSVGGRLWCGCQNRVLVLSPDTL 1847
            LA+G L ++ R     WD  N+  + LG     I  M  V  ++WCG +N++ V+ P  +
Sbjct: 1003 LADGTLAIFHRGVDGQWDLSNYHLLDLGRPHHSIRCMTVVHDKVWCGYRNKIYVVQPKAM 1062

Query: 1848 QLEHMFYVGQDSSRCVACMVDSSLGVWVTLKGSAHVCLYHPDTFEQLAEVDVTPPVHRML 1907
            ++E  F         V  +     GVWV+++  + + LYH  T++ L +VD+ P V +ML
Sbjct: 1063 KIEKSFDAHPRKESQVRQLAWVGDGVWVSIRLDSTLRLYHAHTYQHLQDVDIEPYVSKML 1122

Query: 1908 AGSDAIIRQHKAACLRITALLVCEELLWVGTSAGVVLTMPTS------------PGTVS- 1954
                        + +RITAL+V    LWVGT  GV++++P +            PG+V  
Sbjct: 1123 GTGKLGF-----SFVRITALMVSCNRLWVGTGNGVIISIPLTETNKTSGVPGNRPGSVIR 1177

Query: 1955 ---------------CPRAPLSPTGLG-QGHTGHVRFLAAVQLPDGFNLLCPTPPPPPDT 1998
                            P   ++   L   GH   V+F  AV          P     P +
Sbjct: 1178 VYGDENSDKVTPGTFIPYCSMAHAQLCFHGHRDAVKFFVAV----------PGQVISPQS 1227

Query: 1999 GPEKLPSLEHRDSPWHRGPAPARP--KMLVISGGDGYEDFRLSSGGGSSSETVGRD---- 2052
                      +  P  + P    P   MLVISGG+GY DFR+   GG  SE +G D    
Sbjct: 1228 SSSGTDLTGDKAGPSAQEPGSQTPLKSMLVISGGEGYIDFRMGDEGG-ESELLGEDLPLE 1286

Query: 2053 -----DSTNHLLLWRV 2063
                    +HL++W+V
Sbjct: 1287 PSVTKAERSHLIVWQV 1302


>gi|94557295 mitogen-activated protein kinase 8 interacting protein 3
            isoform 2 [Homo sapiens]
          Length = 1330

 Score =  144 bits (363), Expect = 9e-34
 Identities = 155/602 (25%), Positives = 241/602 (40%), Gaps = 91/602 (15%)

Query: 1513 SPEVWVCNSDGYVGQVCLLSLRAEPDVEACIAVCSARILCIGAVPGLQPRCHREPPPSLR 1572
            S  VW+  S     +V ++       V     VC+A +LCI ++P      +  PP  + 
Sbjct: 764  SSRVWILTSTLTTSKVVIIDANQPGTVVDQFTVCNAHVLCISSIPAASDSDY--PPGEMF 821

Query: 1573 SPPETAPEPAGPELDVEAAADEEAATLAEPGPQPCLHISIAGSGLEMTPGLGEGDPRPEL 1632
               +  PE  G +  +        AT        C       S    TP L +G      
Sbjct: 822  LDSDVNPEDPGADGVLAGITLVGCATRCNVPRSNC-------SSRGDTPVLDKGQGEVAT 874

Query: 1633 VPFDSDSDDESSPSPSGTLQSQASRSTISSSFGNEETPSSKEATAETTSSEEEQEPGFLP 1692
            +     ++ + +PS S    ++A+           E P    +  ET +      PG L 
Sbjct: 875  I-----ANGKVNPSQSTEEATEAT-----------EVPDPGPSEPETAT----LRPGPLT 914

Query: 1693 LSGSFGPGGPCGTSPMDGRALRRSSHGSFTRGSLEDLLSVDPEAYQSS----VWLGTEDG 1748
                  P     + P  G         S TR   E   S DP    SS    +WLG ++G
Sbjct: 915  EHVFTDPAPTPSSGPQPGSENGPEPDSSSTRPEPEP--SGDPTGAGSSAAPTMWLGAQNG 972

Query: 1749 CVHVYQSSDSIRDRRNSMKLQHAASVTCILYLNNQVFVSLANGELVVYQREAGHFWDPQN 1808
             ++V+ +  + +   +S+KL+   SV  ++++  +V V+LA+G L ++ R     WD  N
Sbjct: 973  WLYVHSAVANWKKCLHSIKLKD--SVLSLVHVKGRVLVALADGTLAIFHRGEDGQWDLSN 1030

Query: 1809 FKSVTLGTQGSPITKMVSVGGRLWCGCQNRVLVLSPDTLQLEHMFYVGQDSSRCVACMVD 1868
            +  + LG     I  M  V  R+WCG +N+V V+ P T+Q+E  F         V  +  
Sbjct: 1031 YHLMDLGHPHHSIRCMAVVYDRVWCGYKNKVHVIQPKTMQIEKSFDAHPRRESQVRQLAW 1090

Query: 1869 SSLGVWVTLKGSAHVCLYHPDTFEQLAEVDVTPPVHRMLAGSDAIIRQHKAACLRITALL 1928
               GVWV+++  + + LYH  T + L +VD+ P V +ML        +   + +RITALL
Sbjct: 1091 IGDGVWVSIRLDSTLRLYHAHTHQHLQDVDIEPYVSKMLGTG-----KLGFSFVRITALL 1145

Query: 1929 VCEELLWVGTSAGVVLTMPTSPGTVSCPRAPL-----SPTGLGQGHTGHVRFLAAVQLPD 1983
            V    LWVGT  GVV+++P +  TV   R  L     + T    G       +  V   D
Sbjct: 1146 VAGSRLWVGTGNGVVISIPLTE-TVVLHRGQLLGLRANKTSPTSGEGARPGGIIHVYGDD 1204

Query: 1984 GFNLLCPTPPPPPDTGPEKLPSLEHR----------------------DSPWHRGPAPAR 2021
              +    +  P       +L    HR                      DSP   GP PA 
Sbjct: 1205 SSDRAASSFIPYCSMAQAQLCFHGHRDAVKFFVSVPGNVLATLNGSVLDSP-AEGPGPAA 1263

Query: 2022 P----------KMLVISGGDGYEDFRLSSGGGSSSETVGRDDS----------TNHLLLW 2061
            P           +LV+SGG+GY DFR+  G    +E    D S           +H+++W
Sbjct: 1264 PASEVEGQKLRNVLVLSGGEGYIDFRIGDGEDDETEEGAGDMSQVKPVLSKAERSHIIVW 1323

Query: 2062 RV 2063
            +V
Sbjct: 1324 QV 1325


>gi|94557297 mitogen-activated protein kinase 8 interacting protein 3
            isoform 1 [Homo sapiens]
          Length = 1336

 Score =  144 bits (363), Expect = 9e-34
 Identities = 155/602 (25%), Positives = 241/602 (40%), Gaps = 91/602 (15%)

Query: 1513 SPEVWVCNSDGYVGQVCLLSLRAEPDVEACIAVCSARILCIGAVPGLQPRCHREPPPSLR 1572
            S  VW+  S     +V ++       V     VC+A +LCI ++P      +  PP  + 
Sbjct: 770  SSRVWILTSTLTTSKVVIIDANQPGTVVDQFTVCNAHVLCISSIPAASDSDY--PPGEMF 827

Query: 1573 SPPETAPEPAGPELDVEAAADEEAATLAEPGPQPCLHISIAGSGLEMTPGLGEGDPRPEL 1632
               +  PE  G +  +        AT        C       S    TP L +G      
Sbjct: 828  LDSDVNPEDPGADGVLAGITLVGCATRCNVPRSNC-------SSRGDTPVLDKGQGEVAT 880

Query: 1633 VPFDSDSDDESSPSPSGTLQSQASRSTISSSFGNEETPSSKEATAETTSSEEEQEPGFLP 1692
            +     ++ + +PS S    ++A+           E P    +  ET +      PG L 
Sbjct: 881  I-----ANGKVNPSQSTEEATEAT-----------EVPDPGPSEPETAT----LRPGPLT 920

Query: 1693 LSGSFGPGGPCGTSPMDGRALRRSSHGSFTRGSLEDLLSVDPEAYQSS----VWLGTEDG 1748
                  P     + P  G         S TR   E   S DP    SS    +WLG ++G
Sbjct: 921  EHVFTDPAPTPSSGPQPGSENGPEPDSSSTRPEPEP--SGDPTGAGSSAAPTMWLGAQNG 978

Query: 1749 CVHVYQSSDSIRDRRNSMKLQHAASVTCILYLNNQVFVSLANGELVVYQREAGHFWDPQN 1808
             ++V+ +  + +   +S+KL+   SV  ++++  +V V+LA+G L ++ R     WD  N
Sbjct: 979  WLYVHSAVANWKKCLHSIKLKD--SVLSLVHVKGRVLVALADGTLAIFHRGEDGQWDLSN 1036

Query: 1809 FKSVTLGTQGSPITKMVSVGGRLWCGCQNRVLVLSPDTLQLEHMFYVGQDSSRCVACMVD 1868
            +  + LG     I  M  V  R+WCG +N+V V+ P T+Q+E  F         V  +  
Sbjct: 1037 YHLMDLGHPHHSIRCMAVVYDRVWCGYKNKVHVIQPKTMQIEKSFDAHPRRESQVRQLAW 1096

Query: 1869 SSLGVWVTLKGSAHVCLYHPDTFEQLAEVDVTPPVHRMLAGSDAIIRQHKAACLRITALL 1928
               GVWV+++  + + LYH  T + L +VD+ P V +ML        +   + +RITALL
Sbjct: 1097 IGDGVWVSIRLDSTLRLYHAHTHQHLQDVDIEPYVSKMLGTG-----KLGFSFVRITALL 1151

Query: 1929 VCEELLWVGTSAGVVLTMPTSPGTVSCPRAPL-----SPTGLGQGHTGHVRFLAAVQLPD 1983
            V    LWVGT  GVV+++P +  TV   R  L     + T    G       +  V   D
Sbjct: 1152 VAGSRLWVGTGNGVVISIPLTE-TVVLHRGQLLGLRANKTSPTSGEGARPGGIIHVYGDD 1210

Query: 1984 GFNLLCPTPPPPPDTGPEKLPSLEHR----------------------DSPWHRGPAPAR 2021
              +    +  P       +L    HR                      DSP   GP PA 
Sbjct: 1211 SSDRAASSFIPYCSMAQAQLCFHGHRDAVKFFVSVPGNVLATLNGSVLDSP-AEGPGPAA 1269

Query: 2022 P----------KMLVISGGDGYEDFRLSSGGGSSSETVGRDDS----------TNHLLLW 2061
            P           +LV+SGG+GY DFR+  G    +E    D S           +H+++W
Sbjct: 1270 PASEVEGQKLRNVLVLSGGEGYIDFRIGDGEDDETEEGAGDMSQVKPVLSKAERSHIIVW 1329

Query: 2062 RV 2063
            +V
Sbjct: 1330 QV 1331


>gi|82546845 breakpoint cluster region isoform 2 [Homo sapiens]
          Length = 1227

 Score =  134 bits (337), Expect = 9e-31
 Identities = 97/316 (30%), Positives = 154/316 (48%), Gaps = 46/316 (14%)

Query: 1051 EPTPASKCCSKPQVDMRKHVAMTLLDTEQSYVESLRTLMQGYMQPLKQPENSV--LCDPS 1108
            E T AS+   +  ++MRK V   +L +E++Y+  L  L+   M+PLK    +   +    
Sbjct: 483  ESTKASELDLEKGLEMRKWVLSGILASEETYLSHLEALLLP-MKPLKAAATTSQPVLTSQ 541

Query: 1109 LVDEIFDQIPELLEHHEQFLEQVRHCMQTWHAQQKVGALLVQSFSKDVLVNIYSAYIDNF 1168
             ++ IF ++PEL E H++F + +   +Q W  QQ+VG L  +  S+   + +Y A++DN+
Sbjct: 542  QIETIFFKVPELYEIHKEFYDGLFPRVQQWSHQQRVGDLFQKLASQ---LGVYRAFVDNY 598

Query: 1169 LNAKDAVRVAKEARPAFLKFLEQ-SMRENKE------KQALSDLMIKPVQRIPRYELLVK 1221
              A +      +A   F +  E    R NK+      K +L  L+ KPV R+ R  L++ 
Sbjct: 599  GVAMEMAEKCCQANAQFAEISENLRARSNKDAKDPTTKNSLETLLYKPVDRVTRSTLVLH 658

Query: 1222 DLLKHTPEDHPDHPLLLEAQRNIKQVAERINKGVRSAEEAERHARVLQEIEAHIEGMEDL 1281
            DLLKHTP  HPDHPLL +A R  +     IN                +EI    + M   
Sbjct: 659  DLLKHTPASHPDHPLLQDALRISQNFLSSIN----------------EEITPRRQSMTVK 702

Query: 1282 QAPLRRFLRQEMVIEVKAIGGKKDRSLFLFTDLIVCTTLKRKSGSLRRSSMSLYTAASVI 1341
            +   R+ L+   ++E+   G +K R +FLFTDL++CT LK++SG                
Sbjct: 703  KGEHRQLLKDSFMVEL-VEGARKLRHVFLFTDLLLCTKLKKQSGG--------------- 746

Query: 1342 DTASKYKMLWKLPLED 1357
                +Y   W +PL D
Sbjct: 747  -KTQQYDCKWYIPLTD 761



 Score = 34.7 bits (78), Expect = 0.99
 Identities = 69/289 (23%), Positives = 101/289 (34%), Gaps = 37/289 (12%)

Query: 490 PGGSSGDRGSN------PLDGRDSPSAGGPVGQLEPIPIPAPASPGTRPTLKDLTATLRR 543
           P G+S  R S       P DG D P A  P  + +    P  A PG          T RR
Sbjct: 84  PDGASEPRASASRPQPAPADGADPPPAEEPEARPDGEGSPGKARPG----------TARR 133

Query: 544 AKSFTCSEKPMARRLPRTSALKSSSSELLLTG---PGAEEDPLPLIVQDQYVQEA----- 595
             +    E+   R  P + A   S+ E +  G   PGA+ +  P  V  ++  E      
Sbjct: 134 PGAAASGERD-DRGPPASVAALRSNFERIRKGHGQPGADAEK-PFYVNVEFHHERGLVKV 191

Query: 596 --RQVFEKIQRMGAQ--QDDGSDAPPGSPDWAGDVTRGQ---RSQEELSGPESSLTDEGI 648
             ++V ++I  +G+Q  Q +   +  G+    GD +R     RS E   G +    D  +
Sbjct: 192 NDKEVSDRISSLGSQAMQMERKKSQHGAGSSVGDASRPPYRGRSSESSCGVDGDYEDAEL 251

Query: 649 GADPEPPVAAFCGLGTTGMWRPLSSSSAQTNHHGPGTEDSLGGWALVSPETPPTPGALR- 707
                         G+   W PL     Q+ + G   E    G  L S  T      L  
Sbjct: 252 NPRFLKDNLIDANGGSRPPWPPLEYQPYQSIYVGGMMEGEGKGPLLRSQSTSEQEKRLTW 311

Query: 708 -RRRKVPPS--GSGGSELSNGEAGEAYRSLSDPIPQRHRAATSEEPTGF 753
            RR   P S    GG    +  + E   S  +       +  S  PT +
Sbjct: 312 PRRSYSPRSFEDCGGGYTPDCSSNENLTSSEEDFSSGQSSRVSPSPTTY 360


>gi|82546843 breakpoint cluster region isoform 1 [Homo sapiens]
          Length = 1271

 Score =  134 bits (337), Expect = 9e-31
 Identities = 97/316 (30%), Positives = 154/316 (48%), Gaps = 46/316 (14%)

Query: 1051 EPTPASKCCSKPQVDMRKHVAMTLLDTEQSYVESLRTLMQGYMQPLKQPENSV--LCDPS 1108
            E T AS+   +  ++MRK V   +L +E++Y+  L  L+   M+PLK    +   +    
Sbjct: 483  ESTKASELDLEKGLEMRKWVLSGILASEETYLSHLEALLLP-MKPLKAAATTSQPVLTSQ 541

Query: 1109 LVDEIFDQIPELLEHHEQFLEQVRHCMQTWHAQQKVGALLVQSFSKDVLVNIYSAYIDNF 1168
             ++ IF ++PEL E H++F + +   +Q W  QQ+VG L  +  S+   + +Y A++DN+
Sbjct: 542  QIETIFFKVPELYEIHKEFYDGLFPRVQQWSHQQRVGDLFQKLASQ---LGVYRAFVDNY 598

Query: 1169 LNAKDAVRVAKEARPAFLKFLEQ-SMRENKE------KQALSDLMIKPVQRIPRYELLVK 1221
              A +      +A   F +  E    R NK+      K +L  L+ KPV R+ R  L++ 
Sbjct: 599  GVAMEMAEKCCQANAQFAEISENLRARSNKDAKDPTTKNSLETLLYKPVDRVTRSTLVLH 658

Query: 1222 DLLKHTPEDHPDHPLLLEAQRNIKQVAERINKGVRSAEEAERHARVLQEIEAHIEGMEDL 1281
            DLLKHTP  HPDHPLL +A R  +     IN                +EI    + M   
Sbjct: 659  DLLKHTPASHPDHPLLQDALRISQNFLSSIN----------------EEITPRRQSMTVK 702

Query: 1282 QAPLRRFLRQEMVIEVKAIGGKKDRSLFLFTDLIVCTTLKRKSGSLRRSSMSLYTAASVI 1341
            +   R+ L+   ++E+   G +K R +FLFTDL++CT LK++SG                
Sbjct: 703  KGEHRQLLKDSFMVEL-VEGARKLRHVFLFTDLLLCTKLKKQSGG--------------- 746

Query: 1342 DTASKYKMLWKLPLED 1357
                +Y   W +PL D
Sbjct: 747  -KTQQYDCKWYIPLTD 761



 Score = 34.7 bits (78), Expect = 0.99
 Identities = 69/289 (23%), Positives = 101/289 (34%), Gaps = 37/289 (12%)

Query: 490 PGGSSGDRGSN------PLDGRDSPSAGGPVGQLEPIPIPAPASPGTRPTLKDLTATLRR 543
           P G+S  R S       P DG D P A  P  + +    P  A PG          T RR
Sbjct: 84  PDGASEPRASASRPQPAPADGADPPPAEEPEARPDGEGSPGKARPG----------TARR 133

Query: 544 AKSFTCSEKPMARRLPRTSALKSSSSELLLTG---PGAEEDPLPLIVQDQYVQEA----- 595
             +    E+   R  P + A   S+ E +  G   PGA+ +  P  V  ++  E      
Sbjct: 134 PGAAASGERD-DRGPPASVAALRSNFERIRKGHGQPGADAEK-PFYVNVEFHHERGLVKV 191

Query: 596 --RQVFEKIQRMGAQ--QDDGSDAPPGSPDWAGDVTRGQ---RSQEELSGPESSLTDEGI 648
             ++V ++I  +G+Q  Q +   +  G+    GD +R     RS E   G +    D  +
Sbjct: 192 NDKEVSDRISSLGSQAMQMERKKSQHGAGSSVGDASRPPYRGRSSESSCGVDGDYEDAEL 251

Query: 649 GADPEPPVAAFCGLGTTGMWRPLSSSSAQTNHHGPGTEDSLGGWALVSPETPPTPGALR- 707
                         G+   W PL     Q+ + G   E    G  L S  T      L  
Sbjct: 252 NPRFLKDNLIDANGGSRPPWPPLEYQPYQSIYVGGMMEGEGKGPLLRSQSTSEQEKRLTW 311

Query: 708 -RRRKVPPS--GSGGSELSNGEAGEAYRSLSDPIPQRHRAATSEEPTGF 753
            RR   P S    GG    +  + E   S  +       +  S  PT +
Sbjct: 312 PRRSYSPRSFEDCGGGYTPDCSSNENLTSSEEDFSSGQSSRVSPSPTTY 360


>gi|34452732 phosphatidylinositol-3,4,5-trisphosphate-dependent Rac
            exchange factor 1 [Homo sapiens]
          Length = 1659

 Score =  112 bits (280), Expect = 4e-24
 Identities = 89/302 (29%), Positives = 152/302 (50%), Gaps = 26/302 (8%)

Query: 1039 EAKPPEAARPADEPTPASKCC-SKPQVDMRKHVAMTLLDTEQSYVESLRTLMQGYMQPLK 1097
            + + P AA P+  P P +    S+ Q+ +R  V   +L TE+ YV +LR L   ++  ++
Sbjct: 21   DPRAPGAAAPSSGPGPCAAARESERQLRLRLCVLNEILGTERDYVGTLRFLQSAFLHRIR 80

Query: 1098 QPENSVLCDPSLVDE----IFDQIPELLEHHEQFLEQVRHCMQTW-HAQQKVGALLVQSF 1152
            Q     + +  L +E    +F  I ++LE H+ FL  + +C+     +Q ++G + ++  
Sbjct: 81   QNVADSV-EKGLTEENVKVLFSNIEDILEVHKDFLAALEYCLHPEPQSQHELGNVFLKFK 139

Query: 1153 SKDVLVNIYSAYIDNFLNAKDAVRVAKEAR--PAFLKFLEQSMRENKEKQA---LSDLMI 1207
             K      +  Y +   N + A+R+  E    P    FL   M     K     L   ++
Sbjct: 140  DK------FCVYEEYCSNHEKALRLLVELNKIPTVRAFLLSCMLLGGRKTTDIPLEGYLL 193

Query: 1208 KPVQRIPRYELLVKDLLKHTPEDHPDHPLLLEAQRNIKQVAERINKGVRSAEEAERHARV 1267
             P+QRI +Y LL+K+L K TP  HPDHP +  A + +K V   IN+  R  E+ E     
Sbjct: 194  SPIQRICKYPLLLKELAKRTPGKHPDHPAVQSALQAMKTVCSNINETKRQMEKLE----A 249

Query: 1268 LQEIEAHIEGME--DLQAPLRRFLRQEMVIEVKAIGGKKDRSLFLFTDLIV-CTTLKRKS 1324
            L+++++HIEG E  +L     + L Q  ++++ A G  ++R+ FLF +L+V C    R +
Sbjct: 250  LEQLQSHIEGWEGSNLTDICTQLLLQGTLLKISA-GNIQERAFFLFDNLLVYCKRKSRVT 308

Query: 1325 GS 1326
            GS
Sbjct: 309  GS 310


>gi|229094128 active breakpoint cluster region-related  protein
            isoform c [Homo sapiens]
          Length = 813

 Score =  109 bits (273), Expect = 2e-23
 Identities = 84/327 (25%), Positives = 146/327 (44%), Gaps = 58/327 (17%)

Query: 1042 PPEAARPADEPTPASKCCSKPQVDMRKHVAMTLLDTEQSYVESLRTLMQGYMQPLKQPEN 1101
            PPE   P  E            ++MRK V    L +E+ Y+  L  L+   M+PLK    
Sbjct: 29   PPEGLAPGVEAGKG--------LEMRKLVLSGFLASEEIYINQLEALLLP-MKPLKA--T 77

Query: 1102 SVLCDPSL----VDEIFDQIPELLEHHEQFLEQVRHCMQTWHAQQKVGALLVQSFSKDVL 1157
            +    P L    ++ IF +I ++ E H++F + +   +Q W +Q  +G L  +  S+   
Sbjct: 78   ATTSQPVLTIQQIETIFYKIQDIYEIHKEFYDNLCPKVQQWDSQVTMGHLFQKLASQ--- 134

Query: 1158 VNIYSAYIDNFLNAKDAVRVAKEARPAFLKFLEQ-------SMRENKEKQALSDLMIKPV 1210
            + +Y A++DN+  A +      ++   F K  E+         +++     +  L+ KP+
Sbjct: 135  LGVYKAFVDNYKVALETAEKCSQSNNQFQKISEELKVKGPKDSKDSHTSVTMEALLYKPI 194

Query: 1211 QRIPRYELLVKDLLKHTPEDHPDHPLLLEAQRNIKQVAERINKGVRSAEEAERHARVLQE 1270
             R+ R  L++ DLLKHTP DHPD+PLL +A R  +     IN                ++
Sbjct: 195  DRVTRSTLVLHDLLKHTPVDHPDYPLLQDALRISQNFLSSIN----------------ED 238

Query: 1271 IEAHIEGMEDLQAPLRRFLRQEMVIEVKAIGGKKDRSLFLFTDLIVCTTLKRKSGSLRRS 1330
            I+     +   +   R+ ++   ++EV     +K R +FLFTD+++C  LK+ S    + 
Sbjct: 239  IDPRRTAVTTPKGETRQLVKDGFLVEVSE-SSRKLRHVFLFTDVLLCAKLKKTSAGKHQ- 296

Query: 1331 SMSLYTAASVIDTASKYKMLWKLPLED 1357
                           +Y   W +PL D
Sbjct: 297  ---------------QYDCKWYIPLAD 308


>gi|38679957 active breakpoint cluster region-related  protein isoform
            a [Homo sapiens]
          Length = 859

 Score =  109 bits (273), Expect = 2e-23
 Identities = 84/327 (25%), Positives = 146/327 (44%), Gaps = 58/327 (17%)

Query: 1042 PPEAARPADEPTPASKCCSKPQVDMRKHVAMTLLDTEQSYVESLRTLMQGYMQPLKQPEN 1101
            PPE   P  E            ++MRK V    L +E+ Y+  L  L+   M+PLK    
Sbjct: 75   PPEGLAPGVEAGKG--------LEMRKLVLSGFLASEEIYINQLEALLLP-MKPLKA--T 123

Query: 1102 SVLCDPSL----VDEIFDQIPELLEHHEQFLEQVRHCMQTWHAQQKVGALLVQSFSKDVL 1157
            +    P L    ++ IF +I ++ E H++F + +   +Q W +Q  +G L  +  S+   
Sbjct: 124  ATTSQPVLTIQQIETIFYKIQDIYEIHKEFYDNLCPKVQQWDSQVTMGHLFQKLASQ--- 180

Query: 1158 VNIYSAYIDNFLNAKDAVRVAKEARPAFLKFLEQ-------SMRENKEKQALSDLMIKPV 1210
            + +Y A++DN+  A +      ++   F K  E+         +++     +  L+ KP+
Sbjct: 181  LGVYKAFVDNYKVALETAEKCSQSNNQFQKISEELKVKGPKDSKDSHTSVTMEALLYKPI 240

Query: 1211 QRIPRYELLVKDLLKHTPEDHPDHPLLLEAQRNIKQVAERINKGVRSAEEAERHARVLQE 1270
             R+ R  L++ DLLKHTP DHPD+PLL +A R  +     IN                ++
Sbjct: 241  DRVTRSTLVLHDLLKHTPVDHPDYPLLQDALRISQNFLSSIN----------------ED 284

Query: 1271 IEAHIEGMEDLQAPLRRFLRQEMVIEVKAIGGKKDRSLFLFTDLIVCTTLKRKSGSLRRS 1330
            I+     +   +   R+ ++   ++EV     +K R +FLFTD+++C  LK+ S    + 
Sbjct: 285  IDPRRTAVTTPKGETRQLVKDGFLVEVSE-SSRKLRHVFLFTDVLLCAKLKKTSAGKHQ- 342

Query: 1331 SMSLYTAASVIDTASKYKMLWKLPLED 1357
                           +Y   W +PL D
Sbjct: 343  ---------------QYDCKWYIPLAD 354


>gi|38679954 active breakpoint cluster region-related  protein isoform
            b [Homo sapiens]
          Length = 822

 Score =  108 bits (270), Expect = 5e-23
 Identities = 79/305 (25%), Positives = 141/305 (46%), Gaps = 50/305 (16%)

Query: 1064 VDMRKHVAMTLLDTEQSYVESLRTLMQGYMQPLKQPENSVLCDPSL----VDEIFDQIPE 1119
            ++MRK V    L +E+ Y+  L  L+   M+PLK    +    P L    ++ IF +I +
Sbjct: 52   LEMRKLVLSGFLASEEIYINQLEALLLP-MKPLKA--TATTSQPVLTIQQIETIFYKIQD 108

Query: 1120 LLEHHEQFLEQVRHCMQTWHAQQKVGALLVQSFSKDVLVNIYSAYIDNFLNAKDAVRVAK 1179
            + E H++F + +   +Q W +Q  +G L  +  S+   + +Y A++DN+  A +      
Sbjct: 109  IYEIHKEFYDNLCPKVQQWDSQVTMGHLFQKLASQ---LGVYKAFVDNYKVALETAEKCS 165

Query: 1180 EARPAFLKFLEQ-------SMRENKEKQALSDLMIKPVQRIPRYELLVKDLLKHTPEDHP 1232
            ++   F K  E+         +++     +  L+ KP+ R+ R  L++ DLLKHTP DHP
Sbjct: 166  QSNNQFQKISEELKVKGPKDSKDSHTSVTMEALLYKPIDRVTRSTLVLHDLLKHTPVDHP 225

Query: 1233 DHPLLLEAQRNIKQVAERINKGVRSAEEAERHARVLQEIEAHIEGMEDLQAPLRRFLRQE 1292
            D+PLL +A R  +     IN                ++I+     +   +   R+ ++  
Sbjct: 226  DYPLLQDALRISQNFLSSIN----------------EDIDPRRTAVTTPKGETRQLVKDG 269

Query: 1293 MVIEVKAIGGKKDRSLFLFTDLIVCTTLKRKSGSLRRSSMSLYTAASVIDTASKYKMLWK 1352
             ++EV     +K R +FLFTD+++C  LK+ S    +                +Y   W 
Sbjct: 270  FLVEVSE-SSRKLRHVFLFTDVLLCAKLKKTSAGKHQ----------------QYDCKWY 312

Query: 1353 LPLED 1357
            +PL D
Sbjct: 313  IPLAD 317


>gi|24797153 faciogenital dysplasia protein [Homo sapiens]
          Length = 961

 Score =  103 bits (257), Expect = 2e-21
 Identities = 139/560 (24%), Positives = 215/560 (38%), Gaps = 102/560 (18%)

Query: 826  KSLS-DPSRRGELAGPGFEGPGGEPIREVEPMLPPSSS-EPILVEQRAEPEEPGATRSRA 883
            KSLS DP   G+   P  EGP         P   PS    P+      +P+ P    S  
Sbjct: 113  KSLSLDP---GQSLEPHPEGPQRLRSDPGPPTETPSQRPSPLKRAPGPKPQVPPKP-SYL 168

Query: 884  QSERALPEALPPPATAHRNFHLDPKLADILSPRLIRRGSKKRPARSSHQELRRDEGSQDQ 943
            Q  R  P   P P    R    DP++A  L+PR                           
Sbjct: 169  QMPRMPPPLEPIPPPPSRPLPADPRVAKGLAPR--------------------------- 201

Query: 944  TGSLSRARPSSRHVRHASVPATFMPIVVPEPPTSVGPPVAVPEPIGFP--TRAHPTLQAP 1001
                + A PSS  V          P++V       GP    PEP+  P  T   P  Q P
Sbjct: 202  ----AEASPSSAAVSSLIEKFEREPVIVASDRPVPGPSPGPPEPVMLPQPTSQPPVPQLP 257

Query: 1002 SLEDVTKQYML-----------NLHSG--EVPAPVPVDMPCL----------------PL 1032
              E     ++L           N  SG   + +P   +  C                  L
Sbjct: 258  EGEASRCLFLLAPGPRDGEKVPNRDSGIDSISSPSNSEETCFVSDDGPPSHSLCPGPPAL 317

Query: 1033 AAPPSAEAKP-------------------PEAARPADEPTPASKCCSKPQVDMRK---HV 1070
            A+ P A A P                    E  +  + P P  +     ++ +++   H+
Sbjct: 318  ASVPVALADPHRPGSQEVDSDLEEEDDEEEEEEKDREIPVPLMERQESVELTVQQKVFHI 377

Query: 1071 AMTLLDTEQSYVESLRTLMQGYM-QPLKQPENSVLCDPSLVDEIFDQIPELLEHHEQFL- 1128
            A  LL TE++YV  L  L Q +  + L++  N       +V  IF  I  +   H+QFL 
Sbjct: 378  ANELLQTEKAYVSRLHLLDQVFCARLLEEARNRSSFPADVVHGIFSNICSIYCFHQQFLL 437

Query: 1129 EQVRHCMQTWHAQQKVGALLVQSFSKDVLVNIYSAYIDNFLNAKDAVRVAKEARPAFLKF 1188
             ++   M+ W    ++G +L +       + +Y  Y+ NF  A + V    E    F   
Sbjct: 438  PELEKRMEEWDRYPRIGDILQKLAP---FLKMYGEYVKNFDRAVELVNTWTERSTQFKVI 494

Query: 1189 LEQSMRENK-EKQALSDLMIKPVQRIPRYELLVKDLLKHTPEDHPDHPLLLEAQRNIKQV 1247
            + +  +E       L   M++PVQRIPRYELL+KD L   P   PD     +AQ++++ +
Sbjct: 495  IHEVQKEEACGNLTLQHHMLEPVQRIPRYELLLKDYLLKLPHGSPDSK---DAQKSLELI 551

Query: 1248 AERINKGVRSAEEAERHARVLQEIEAHIEGMEDLQAPLRRFLRQEMVIEVKAIGG-KKDR 1306
            A        +  + ER  ++L+  E  + G ED+ +P +  +++  ++++ A  G  +DR
Sbjct: 552  ATAAEHSNAAIRKMERMHKLLKVYEL-LGGEEDIVSPTKELIKEGHILKLSAKNGTTQDR 610

Query: 1307 SLFLFTD-LIVCTTLKRKSG 1325
             L LF D L+ C    R  G
Sbjct: 611  YLILFNDRLLYCVPRLRLLG 630



 Score = 37.4 bits (85), Expect = 0.15
 Identities = 75/300 (25%), Positives = 103/300 (34%), Gaps = 65/300 (21%)

Query: 218 HIFSQPQAGARASCSSSSIAASYPVSRSRAASSS------EEEEEGPPQ----------- 260
           H  + P   A  +C+ S   AS P   +R  S S      + +  GP             
Sbjct: 17  HPATNPPGAAPPACADSDPGASEPGLLARRGSGSALGGPLDPQFVGPSDTSLGAAPGHRV 76

Query: 261 LPGAQSPAYHGG-----HSSGSDDDRDGEGGHRWGGRPGLRPGSSLLDQDCRPD-SDGLN 314
           LP   SP +H       H  GS              RPGL  G+ +L +    D    L 
Sbjct: 77  LPCGPSPQHHRALRFSYHLEGSQP------------RPGLHQGNRILVKSLSLDPGQSLE 124

Query: 315 LSSMNSAGVSGSPEPPTSPRAPREEGLREWGSGSP-----------PCVPGPQEGL-RPM 362
                   +   P PPT   + R   L+      P           P +P P E +  P 
Sbjct: 125 PHPEGPQRLRSDPGPPTETPSQRPSPLKRAPGPKPQVPPKPSYLQMPRMPPPLEPIPPPP 184

Query: 363 SDSVGGAFRVAKVSFPSYLASPAGSRGSSRYSSTETLKDDDLWSSRGSGGWGVYRSPSFG 422
           S  +    RVAK   P   ASP+ +  SS     E  +   + S R   G      PS G
Sbjct: 185 SRPLPADPRVAKGLAPRAEASPSSAAVSSLIEKFER-EPVIVASDRPVPG------PSPG 237

Query: 423 AGEGLLRSQARTRAKGP----GGTSRAL-------RDGGFEPEKSRQRKSLSNPDIASET 471
             E ++  Q  ++   P    G  SR L       RDG   P +     S+S+P  + ET
Sbjct: 238 PPEPVMLPQPTSQPPVPQLPEGEASRCLFLLAPGPRDGEKVPNRDSGIDSISSPSNSEET 297


>gi|21735572 epithelial cell transforming sequence 2 oncogene protein
            [Homo sapiens]
          Length = 883

 Score =  103 bits (256), Expect = 2e-21
 Identities = 61/209 (29%), Positives = 115/209 (55%), Gaps = 5/209 (2%)

Query: 1067 RKHVAMTLLDTEQSYVESLRTLMQGYMQPLKQP--ENSVLCDPSLVDEIFDQIPELLEHH 1124
            R  VA  L  TE +YV  L T++Q +  PL++       +  P  +  IF  IP++ + H
Sbjct: 422  RWQVAKELYQTESNYVNILATIIQLFQVPLEEEGQRGGPILAPEEIKTIFGSIPDIFDVH 481

Query: 1125 EQFLEQVRHCMQTWHAQQKVGALLVQSFSKDVLVNIYSAYIDNFLNAKDAVRVAKEARPA 1184
             +  + +   +  W   + +G + ++ +SKD LV  Y  +++ F  +K+ +   ++ +P 
Sbjct: 482  TKIKDDLEDLIVNWDESKSIGDIFLK-YSKD-LVKTYPPFVNFFEMSKETIIKCEKQKPR 539

Query: 1185 FLKFLEQSMRENK-EKQALSDLMIKPVQRIPRYELLVKDLLKHTPEDHPDHPLLLEAQRN 1243
            F  FL+ +  + +  +Q+L +L+I+PVQR+P   LL+ DL KHT +++PD   L +A  +
Sbjct: 540  FHAFLKINQAKPECGRQSLVELLIRPVQRLPSVALLLNDLKKHTADENPDKSTLEKAIGS 599

Query: 1244 IKQVAERINKGVRSAEEAERHARVLQEIE 1272
            +K+V   IN+  R  E  ++   V+ E++
Sbjct: 600  LKEVMTHINEDKRKTEAQKQIFDVVYEVD 628


>gi|47578117 DEP domain containing 2 isoform b [Homo sapiens]
          Length = 979

 Score =  102 bits (253), Expect = 5e-21
 Identities = 84/281 (29%), Positives = 139/281 (49%), Gaps = 22/281 (7%)

Query: 1063 QVDMRKHVAMTLLDTEQSYVESLRTLMQGYMQPLKQPENSVLCDPSLVDE----IFDQIP 1118
            Q+ +R  V   L  TE+ YV +L  L+  ++  + Q   S + D ++ +E    +F  I 
Sbjct: 20   QLRLRVCVLSELQKTERDYVGTLEFLVSAFLHRMNQCAASKV-DKNVTEETVKMLFSNIE 78

Query: 1119 ELLEHHEQFLEQVRHCMQTW-HAQQKVGALLVQSFSKDVLVNIYSAYIDNFLNAKDAVRV 1177
            ++L  H++FL+ V  C+    +AQQ+VG   +    K     IY  Y  N   A+  +  
Sbjct: 79   DILAVHKEFLKVVEECLHPEPNAQQEVGTCFLHFKDK---FRIYDEYCSNHEKAQKLLLE 135

Query: 1178 AKEARPAFLKFLEQSMRENKEKQA---LSDLMIKPVQRIPRYELLVKDLLKHTPEDHPDH 1234
              + R     FL   M     K     L   ++ P+QRI +Y L++K+LLK TP  H D+
Sbjct: 136  LNKIR-TIRTFLLNCMLLGGRKNTDVPLEGYLVTPIQRICKYPLILKELLKRTPRKHSDY 194

Query: 1235 PLLLEAQRNIKQVAERINKGVRSAEEAERHARVLQEIEAHIEGME--DLQAPLRRFLRQE 1292
              ++EA + +K V   IN+  R  E+ E    VL+E ++HIEG E  ++       L   
Sbjct: 195  AAVMEALQAMKAVCSNINEAKRQMEKLE----VLEEWQSHIEGWEGSNITDTCTEMLMCG 250

Query: 1293 MVIEVKAIGGKKDRSLFLFTDLIVCTTLKRKSGSLRRSSMS 1333
            +++++ + G  ++R  FLF +L+V    KRK   L+ S  S
Sbjct: 251  VLLKISS-GNIQERVFFLFDNLLV--YCKRKHRRLKNSKAS 288


>gi|47578115 DEP domain containing 2 isoform a [Homo sapiens]
          Length = 1606

 Score =  102 bits (253), Expect = 5e-21
 Identities = 84/281 (29%), Positives = 139/281 (49%), Gaps = 22/281 (7%)

Query: 1063 QVDMRKHVAMTLLDTEQSYVESLRTLMQGYMQPLKQPENSVLCDPSLVDE----IFDQIP 1118
            Q+ +R  V   L  TE+ YV +L  L+  ++  + Q   S + D ++ +E    +F  I 
Sbjct: 20   QLRLRVCVLSELQKTERDYVGTLEFLVSAFLHRMNQCAASKV-DKNVTEETVKMLFSNIE 78

Query: 1119 ELLEHHEQFLEQVRHCMQTW-HAQQKVGALLVQSFSKDVLVNIYSAYIDNFLNAKDAVRV 1177
            ++L  H++FL+ V  C+    +AQQ+VG   +    K     IY  Y  N   A+  +  
Sbjct: 79   DILAVHKEFLKVVEECLHPEPNAQQEVGTCFLHFKDK---FRIYDEYCSNHEKAQKLLLE 135

Query: 1178 AKEARPAFLKFLEQSMRENKEKQA---LSDLMIKPVQRIPRYELLVKDLLKHTPEDHPDH 1234
              + R     FL   M     K     L   ++ P+QRI +Y L++K+LLK TP  H D+
Sbjct: 136  LNKIR-TIRTFLLNCMLLGGRKNTDVPLEGYLVTPIQRICKYPLILKELLKRTPRKHSDY 194

Query: 1235 PLLLEAQRNIKQVAERINKGVRSAEEAERHARVLQEIEAHIEGME--DLQAPLRRFLRQE 1292
              ++EA + +K V   IN+  R  E+ E    VL+E ++HIEG E  ++       L   
Sbjct: 195  AAVMEALQAMKAVCSNINEAKRQMEKLE----VLEEWQSHIEGWEGSNITDTCTEMLMCG 250

Query: 1293 MVIEVKAIGGKKDRSLFLFTDLIVCTTLKRKSGSLRRSSMS 1333
            +++++ + G  ++R  FLF +L+V    KRK   L+ S  S
Sbjct: 251  VLLKISS-GNIQERVFFLFDNLLV--YCKRKHRRLKNSKAS 288


>gi|134133248 FYVE, RhoGEF and PH domain containing 3 [Homo sapiens]
          Length = 725

 Score =  101 bits (252), Expect = 7e-21
 Identities = 82/303 (27%), Positives = 138/303 (45%), Gaps = 22/303 (7%)

Query: 1018 EVPAPVPVDMPCLPLAAPPSAEAKPPEAARPADEPTPASKCCSKPQVDMRKHVAMTLLDT 1077
            +VP   P +     +   P +E  P +A + A          S PQ  +  H+A  LL T
Sbjct: 116  QVPKVTPQEEADSDVGEEPDSENTPQKADKDAGLAQH-----SGPQKLL--HIAQELLHT 168

Query: 1078 EQSYVESLRTLMQGYMQPLKQPENSVLCDPSLVDEIFDQIPELLEHHEQFL--EQVRHCM 1135
            E++YV+ L  L Q +   L          P ++  IF  I  +   H QFL  E      
Sbjct: 169  EETYVKRLHLLDQVFCTRLTDAG----IPPEVIMGIFSNISSIHRFHGQFLLPELKTRIT 224

Query: 1136 QTWHAQQKVGALLVQSFSKDVLVNIYSAYIDNFLNAKDAVRVAKEARPAFLKFLEQSMRE 1195
            + W    ++G +L +       + +Y  Y+ NF  A   V    +  P F   +    ++
Sbjct: 225  EEWDTNPRLGDILQKLAP---FLKMYGEYVKNFDRAVGLVSTWTQRSPLFKDVVHSIQKQ 281

Query: 1196 NK-EKQALSDLMIKPVQRIPRYELLVKDLLKHTPEDHPDHPLLLEAQRNIKQVAERINKG 1254
                   L   M++PVQR+PRYELL+KD LK  P+D PD     +A+R+++ ++   N  
Sbjct: 282  EVCGNLTLQHHMLEPVQRVPRYELLLKDYLKRLPQDAPDRK---DAERSLELISTAANHS 338

Query: 1255 VRSAEEAERHARVLQEIEAHIEGMEDLQAPLRRFLRQEMVIEVKAIGG-KKDRSLFLFTD 1313
              +  + E+  ++L E+   + G ED+  P    +++  + ++ A  G  +DR LFLF  
Sbjct: 339  NAAIRKVEKMHKLL-EVYEQLGGEEDIVNPANELIKEGQIQKLSAKNGTPQDRHLFLFNS 397

Query: 1314 LIV 1316
            +I+
Sbjct: 398  MIL 400


>gi|134133265 FYVE, RhoGEF and PH domain containing 3 [Homo sapiens]
          Length = 725

 Score =  101 bits (252), Expect = 7e-21
 Identities = 82/303 (27%), Positives = 138/303 (45%), Gaps = 22/303 (7%)

Query: 1018 EVPAPVPVDMPCLPLAAPPSAEAKPPEAARPADEPTPASKCCSKPQVDMRKHVAMTLLDT 1077
            +VP   P +     +   P +E  P +A + A          S PQ  +  H+A  LL T
Sbjct: 116  QVPKVTPQEEADSDVGEEPDSENTPQKADKDAGLAQH-----SGPQKLL--HIAQELLHT 168

Query: 1078 EQSYVESLRTLMQGYMQPLKQPENSVLCDPSLVDEIFDQIPELLEHHEQFL--EQVRHCM 1135
            E++YV+ L  L Q +   L          P ++  IF  I  +   H QFL  E      
Sbjct: 169  EETYVKRLHLLDQVFCTRLTDAG----IPPEVIMGIFSNISSIHRFHGQFLLPELKTRIT 224

Query: 1136 QTWHAQQKVGALLVQSFSKDVLVNIYSAYIDNFLNAKDAVRVAKEARPAFLKFLEQSMRE 1195
            + W    ++G +L +       + +Y  Y+ NF  A   V    +  P F   +    ++
Sbjct: 225  EEWDTNPRLGDILQKLAP---FLKMYGEYVKNFDRAVGLVSTWTQRSPLFKDVVHSIQKQ 281

Query: 1196 NK-EKQALSDLMIKPVQRIPRYELLVKDLLKHTPEDHPDHPLLLEAQRNIKQVAERINKG 1254
                   L   M++PVQR+PRYELL+KD LK  P+D PD     +A+R+++ ++   N  
Sbjct: 282  EVCGNLTLQHHMLEPVQRVPRYELLLKDYLKRLPQDAPDRK---DAERSLELISTAANHS 338

Query: 1255 VRSAEEAERHARVLQEIEAHIEGMEDLQAPLRRFLRQEMVIEVKAIGG-KKDRSLFLFTD 1313
              +  + E+  ++L E+   + G ED+  P    +++  + ++ A  G  +DR LFLF  
Sbjct: 339  NAAIRKVEKMHKLL-EVYEQLGGEEDIVNPANELIKEGQIQKLSAKNGTPQDRHLFLFNS 397

Query: 1314 LIV 1316
            +I+
Sbjct: 398  MIL 400


>gi|154240686 FYVE, RhoGEF and PH domain containing 6 [Homo sapiens]
          Length = 1430

 Score = 99.0 bits (245), Expect = 4e-20
 Identities = 88/345 (25%), Positives = 157/345 (45%), Gaps = 23/345 (6%)

Query: 1069 HVAMTLLDTEQSYVESLRTLMQGYMQPLKQPENSVLCDPSLVDEIFDQI----PELLEHH 1124
            H+A  ++ +E+ +V+ L+ L   +   +       L  P + D I +QI    P+L E +
Sbjct: 874  HIAKEIMSSEKVFVDVLKLLHIDFRDAVAHASRQ-LGKPVIEDRILNQILYYLPQLYELN 932

Query: 1125 EQFLEQVRHCMQTWHAQQKVGALLVQSFSKDVLVNIYSAYIDNFLNAKDAVRVAKEARPA 1184
               L+++   M  W  QQ++  + V+   K   + +YS YI  F      +    +  P 
Sbjct: 933  RDLLKELEERMLHWTEQQRIADIFVK---KGPYLKMYSTYIKEFDKNIALLDEQCKKNPG 989

Query: 1185 FLKFLEQ-SMRENKEKQALSDLMIKPVQRIPRYELLVKDLLKHTPEDHPDHPLLLEAQRN 1243
            F   + +  M       AL   ++KPVQRIP+Y LL+ D LK+  ED  D+    +A   
Sbjct: 990  FAAVVREFEMSPRCANLALKHYLLKPVQRIPQYRLLLTDYLKNLIEDAGDYRDTQDALAV 1049

Query: 1244 IKQVAERINKGVRSAEEAERHARVLQEIEAHIEGMEDLQAPLRRFLRQEMVIEVKAIGGK 1303
            + +VA   N  ++  +  ++    L +I+  + G  ++  P R FL++ +++++      
Sbjct: 1050 VIEVANHANDTMKQGDNFQK----LMQIQYSLNGHHEIVQPGRVFLKEGILMKLSR-KVM 1104

Query: 1304 KDRSLFLFTDLIVCTTLKRKSGSLRRSSMSLYTAASVIDTASKYKMLWKLPLEDADIIKG 1363
            + R  FLF D ++ TT  +       + +SL        T   Y+   K+   +   I  
Sbjct: 1105 QPRMFFLFNDALLYTTPVQSGMYKLNNMLSLAGMKVRKPTQEAYQNELKIESVERSFILS 1164

Query: 1364 ASQATNRENIQKAISRLDEDLTTLGQMSKLSESLGF-PHQSLDDA 1407
            AS AT R+   +AISR  E+           + + F P +SLD+A
Sbjct: 1165 ASSATERDEWLEAISRAIEEYA--------KKRITFCPSRSLDEA 1201


>gi|189217917 FYVE, RhoGEF and PH domain containing 2 [Homo sapiens]
          Length = 655

 Score = 94.0 bits (232), Expect = 1e-18
 Identities = 78/278 (28%), Positives = 130/278 (46%), Gaps = 16/278 (5%)

Query: 1044 EAARPADEPTPASKCCSKPQVDMRKHVAMTLLDTEQSYVESLRTLMQGYMQPLKQPENSV 1103
            EA R + +P   S   ++   +  K +   LL+TEQ+YV  L  L Q + Q L +   S 
Sbjct: 83   EAWRKSCQPVTLSGSGTQ---EPEKKIVQELLETEQAYVARLHLLDQVFFQELLKTARSS 139

Query: 1104 LCDPS-LVDEIFDQIPELLEHHEQF-LEQVRHCMQTWHAQQKVGALLVQSFSKDVLVNIY 1161
               P  +V  IF  I  + + H QF L +++  +  W A  ++G + +Q  +    + +Y
Sbjct: 140  KAFPEDVVRVIFSNISSIYQFHSQFFLPELQRRLDDWTANPRIGDV-IQKLAP--FLKMY 196

Query: 1162 SAYIDNFLNAKDAVRVAKEARPAFLKFLEQ-SMRENKEKQALSDLMIKPVQRIPRYELLV 1220
            S Y+ NF  A + +    +  P F + L +    E      L   M++PVQRIPRYELL+
Sbjct: 197  SEYVKNFERAAELLATWTDKSPLFQEVLTRIQSSEASGSLTLQHHMLEPVQRIPRYELLL 256

Query: 1221 KDLLKHTPEDHPDHPLLLEAQRNIKQVAERINKGVRSAEEAERHARVLQEIEAHIEGME- 1279
            K+ ++  P   PD     +A   I   A+  N  +   E  +    V Q +     G+E 
Sbjct: 257  KEYIQKLPAQAPDQADAQKALDMIFSAAQHSNAAITEMERLQDLWEVYQRL-----GLED 311

Query: 1280 DLQAPLRRFLRQEMVIEVK-AIGGKKDRSLFLFTDLIV 1316
            D+  P    LR+  V+++        +R LFLF ++++
Sbjct: 312  DIVDPSNTLLREGPVLKISFRRNDPMERYLFLFNNMLL 349


>gi|198041928 FYVE, RhoGEF and PH domain containing 4 [Homo sapiens]
          Length = 766

 Score = 93.6 bits (231), Expect = 2e-18
 Identities = 69/250 (27%), Positives = 119/250 (47%), Gaps = 10/250 (4%)

Query: 1070 VAMTLLDTEQSYVESLRTLMQGYMQPLKQPENSVLCDPSLVDEIFDQIPELLEHHEQFL- 1128
            +A  LL TE++YV  L  L Q +   L +  N       +V++IF  I  +   H +FL 
Sbjct: 210  IANELLLTERAYVNRLDLLDQVFYCKLLEEANRGSFPAEMVNKIFSNISSINAFHSKFLL 269

Query: 1129 EQVRHCMQTWHAQQKVGALLVQSFSKDVLVNIYSAYIDNFLNAKDAVRVAKEARPAFLKF 1188
             ++   MQ W    ++G +L +       + +Y  Y+  F NA + V+   E  P F   
Sbjct: 270  PELEKRMQEWETTPRIGDILQKLAP---FLKMYGEYVKGFDNAMELVKNMTERIPQFKSV 326

Query: 1189 LEQSMRENK-EKQALSDLMIKPVQRIPRYELLVKDLLKHTPEDHPDHPLLLEAQRNIKQV 1247
            +E+  ++       L   M++PVQRIPRYE+L+KD L+  P D  D     ++   I   
Sbjct: 327  VEEIQKQKICGSLTLQHHMLEPVQRIPRYEMLLKDYLRKLPPDSLDWNDAKKSLEIISTA 386

Query: 1248 AERINKGVRSAEEAERHARVLQEIEAHIEGMEDLQAPLRRFLRQEMVIEVKAIG-GKKDR 1306
            A   N  +R  E  ++    L EI   +   ED+  P    +++  ++++ A     ++R
Sbjct: 387  ASHSNSAIRKMENLKK----LLEIYEMLGEEEDIVNPSNELIKEGQILKLAARNTSAQER 442

Query: 1307 SLFLFTDLIV 1316
             LFLF ++++
Sbjct: 443  YLFLFNNMLL 452


>gi|58331187 T-cell lymphoma invasion and metastasis 2 isoform a [Homo
            sapiens]
          Length = 1701

 Score = 92.8 bits (229), Expect = 3e-18
 Identities = 85/364 (23%), Positives = 153/364 (42%), Gaps = 29/364 (7%)

Query: 1038 AEAKPPEAARPADEPTPASKCCSKPQVDMRKHVAMTLLDTEQSYVESLRTLMQGYMQPLK 1097
            ++A   E  R   +P P          D  + V   L+DTE+SYV+ L  L + Y++PL 
Sbjct: 1071 SQANGMEGPRENQDPPPRPLARHLSDADRLRKVIQELVDTEKSYVKDLSCLFELYLEPL- 1129

Query: 1098 QPENSVLCDPSLVDEIFDQIPELLEHHEQFLEQVRHCMQTWHAQQKVGALLVQSFSKDVL 1157
              +N        ++ +F  +PE+LE  + FLE +   +    A      L   S  + +L
Sbjct: 1130 --QNETFLTQDEMESLFGSLPEMLEFQKVFLETLEDGIS---ASSDFNTLETPSQFRKLL 1184

Query: 1158 VNI-------------YSAYIDNFLNAKDAVRVAKEARPAFLKFLEQSMRENKEKQALSD 1204
             ++             YS +  N +  +  +  AK  + AF  FL+      +    L  
Sbjct: 1185 FSLGGSFLYYADHFKLYSGFCANHIKVQKVLERAKTDK-AFKAFLDARNPTKQHSSTLES 1243

Query: 1205 LMIKPVQRIPRYELLVKDLLKHTPEDHPDHPLLLEAQRNIKQVAERINKGVRSAEEAERH 1264
             +IKPVQR+ +Y LL+K+L+  T ++  +H  L EA + +++VA  IN+  +  E+   +
Sbjct: 1244 YLIKPVQRVLKYPLLLKELVSLTDQESEEHYHLTEALKAMEKVASHINEMQKIYED---Y 1300

Query: 1265 ARVLQEIEAHIEGMED--LQAPLRRFLRQEMVIEVK---AIG-GKKDRSLFLFTDLIVCT 1318
              V  ++ A   G E    +  +   L    V  +    ++G  +KD  L +F       
Sbjct: 1301 GTVFDQLVAEQSGTEKEVTELSMGELLMHSTVSWLNPFLSLGKARKDLELTVFVFKRAVI 1360

Query: 1319 TLKRKSGSLRRSSMSLYTAASVIDTASKYKMLWKLPLEDADIIKGASQATNRENIQKAIS 1378
             + +++  L++   S    A        +K  W +P+    +  G    T   +I + I 
Sbjct: 1361 LVYKENCKLKKKLPSNSRPAHNSTDLDPFKFRWLIPISALQVRLGNPAGTENNSIWELIH 1420

Query: 1379 RLDE 1382
               E
Sbjct: 1421 TKSE 1424


>gi|47717123 intersectin 1 isoform ITSN-l [Homo sapiens]
          Length = 1721

 Score = 92.4 bits (228), Expect = 4e-18
 Identities = 77/307 (25%), Positives = 147/307 (47%), Gaps = 35/307 (11%)

Query: 1042 PPEAARPADEPTPASKCCSK--------PQVDMRKHVAMTLLDTEQSYVESLRTLMQGYM 1093
            P    +   +  P+ + CS         P    R+     L+ TE++YV  L+ + + + 
Sbjct: 1205 PSNYVKLTTDMDPSQQWCSDLHLLDMLTPTERKRQGYIHELIVTEENYVNDLQLVTEIFQ 1264

Query: 1094 QPLKQPENSVLCDPSLVDEIFDQIPELLEHHEQFLEQVRHCMQTWHAQQKVGALLVQSFS 1153
            +PL + E   L     V  IF    EL+  + + L+ +R  ++   + +K+   ++    
Sbjct: 1265 KPLMESE---LLTEKEVAMIFVNWKELIMCNIKLLKALR--VRKKMSGEKMPVKMIGDIL 1319

Query: 1154 KDVLVNI--YSAYIDNFLNAKDAVRVAKEARPAFLKFLEQSMRENKEK-QALSDLMIKPV 1210
               L ++  Y  +    LN    ++   +  P F +F+++   + + K   LS  ++KP+
Sbjct: 1320 SAQLPHMQPYIRFCSRQLNGAALIQQKTDEAPDFKEFVKRLAMDPRCKGMPLSSFILKPM 1379

Query: 1211 QRIPRYELLVKDLLKHTPEDHPDHPLLLEAQRNIKQVAERINKGVRSAEEAERHARVLQE 1270
            QR+ RY L++K++L++TPE+HPDH  L  A    +++  ++N+GVR  E ++R    L+ 
Sbjct: 1380 QRVTRYPLIIKNILENTPENHPDHSHLKHALEKAEELCSQVNEGVREKENSDR----LEW 1435

Query: 1271 IEAHIEGMEDLQAPL-----------RRFLRQEMVIEVKAIGGKKDRSLFLFTDLIVCTT 1319
            I+AH++  E L   L           R+FL    + + K+    K+   FLF D ++ T 
Sbjct: 1436 IQAHVQ-CEGLSEQLVFNSVTNCLGPRKFLHSGKLYKAKS---NKELYGFLFNDFLLLTQ 1491

Query: 1320 LKRKSGS 1326
            + +  GS
Sbjct: 1492 ITKPLGS 1498



 Score = 33.9 bits (76), Expect = 1.7
 Identities = 34/144 (23%), Positives = 54/144 (37%), Gaps = 25/144 (17%)

Query: 614 DAPPGSPDWAGDVTRGQRS-----------QEELSGPESSLTDEGIGADPE-------PP 655
           ++  G P W G   +G+             + E+  P   +TD      P+        P
Sbjct: 776 ESQTGEPGWLGGELKGKTGWFPANYAEKIPENEVPAPVKPVTDSTSAPAPKLALRETPAP 835

Query: 656 VAAFCGLGTT--GMWRPLSSSSAQTNHHGPGTEDSLGGWALVSPETPPTPGALRRRRKVP 713
           +A      +T    W   SS+   + +  P T D+   WA     T P+ G LR+R    
Sbjct: 836 LAVTSSEPSTTPNNWADFSSTWPTSTNEKPET-DNWDAWAAQPSLTVPSAGQLRQRSAFT 894

Query: 714 PSGSGGSE----LSNGEAGEAYRS 733
           P+ + GS     L  GE  E  ++
Sbjct: 895 PATATGSSPSPVLGQGEKVEGLQA 918


>gi|58331189 T-cell lymphoma invasion and metastasis 2 isoform b [Homo
            sapiens]
          Length = 626

 Score = 91.7 bits (226), Expect = 7e-18
 Identities = 84/358 (23%), Positives = 150/358 (41%), Gaps = 29/358 (8%)

Query: 1044 EAARPADEPTPASKCCSKPQVDMRKHVAMTLLDTEQSYVESLRTLMQGYMQPLKQPENSV 1103
            E  R   +P P          D  + V   L+DTE+SYV+ L  L + Y++PL   +N  
Sbjct: 2    EGPRENQDPPPRPLARHLSDADRLRKVIQELVDTEKSYVKDLSCLFELYLEPL---QNET 58

Query: 1104 LCDPSLVDEIFDQIPELLEHHEQFLEQVRHCMQTWHAQQKVGALLVQSFSKDVLVNI--- 1160
                  ++ +F  +PE+LE  + FLE +   +    A      L   S  + +L ++   
Sbjct: 59   FLTQDEMESLFGSLPEMLEFQKVFLETLEDGIS---ASSDFNTLETPSQFRKLLFSLGGS 115

Query: 1161 ----------YSAYIDNFLNAKDAVRVAKEARPAFLKFLEQSMRENKEKQALSDLMIKPV 1210
                      YS +  N +  +  +  AK  + AF  FL+      +    L   +IKPV
Sbjct: 116  FLYYADHFKLYSGFCANHIKVQKVLERAKTDK-AFKAFLDARNPTKQHSSTLESYLIKPV 174

Query: 1211 QRIPRYELLVKDLLKHTPEDHPDHPLLLEAQRNIKQVAERINKGVRSAEEAERHARVLQE 1270
            QR+ +Y LL+K+L+  T ++  +H  L EA + +++VA  IN+  +  E+   +  V  +
Sbjct: 175  QRVLKYPLLLKELVSLTDQESEEHYHLTEALKAMEKVASHINEMQKIYED---YGTVFDQ 231

Query: 1271 IEAHIEGMED--LQAPLRRFLRQEMVIEVK---AIG-GKKDRSLFLFTDLIVCTTLKRKS 1324
            + A   G E    +  +   L    V  +    ++G  +KD  L +F        + +++
Sbjct: 232  LVAEQSGTEKEVTELSMGELLMHSTVSWLNPFLSLGKARKDLELTVFVFKRAVILVYKEN 291

Query: 1325 GSLRRSSMSLYTAASVIDTASKYKMLWKLPLEDADIIKGASQATNRENIQKAISRLDE 1382
              L++   S    A        +K  W +P+    +  G    T   +I + I    E
Sbjct: 292  CKLKKKLPSNSRPAHNSTDLDPFKFRWLIPISALQVRLGNPAGTENNSIWELIHTKSE 349


>gi|120432044 vav 3 guanine nucleotide exchange factor isoform 1 [Homo
            sapiens]
          Length = 847

 Score = 89.4 bits (220), Expect = 3e-17
 Identities = 74/269 (27%), Positives = 136/269 (50%), Gaps = 28/269 (10%)

Query: 1062 PQVDMRKHVAMTLLDTEQSYVESLRTLMQGYMQPLKQPENSVLCDPSLVDEIFDQIPELL 1121
            P+ D+R      +  TE+ Y E+L ++ + +M PLK+         +  D +F  IPEL+
Sbjct: 188  PENDIRSCCLAEIKQTEEKYTETLESIEKYFMAPLKR-----FLTAAEFDSVFINIPELV 242

Query: 1122 EHHEQFLEQVRHCMQTWHAQQKVGALLVQSFSKDVLVNIYSAYIDNFLNAKDAVRVAKEA 1181
            + H   ++++   +   +  Q +  + +    + V+   Y + +++ +++ D +   KE 
Sbjct: 243  KLHRNLMQEIHDSIVNKN-DQNLYQVFINYKERLVIYGQYCSGVESAISSLDYISKTKE- 300

Query: 1182 RPAFLKFLEQSMRENKEKQALSDLMIKPVQRIPRYELLVKDLLKHT--PEDHPDHPLLLE 1239
                LK  E S R N  K  L DL++ P+QR+ +Y LL+++L+KHT  P +  +  L L+
Sbjct: 301  -DVKLKLEECSKRANNGKFTLRDLLVVPMQRVLKYHLLLQELVKHTTDPTEKANLKLALD 359

Query: 1240 AQRNIKQVAERINKGVRSAEEAERHARVLQEIEAHIEGMEDLQAPLRRFLRQEMVIEVKA 1299
            A   +K +A+ +N       E +R    L+EI+     +E+L  P+  F R +   E++ 
Sbjct: 360  A---MKDLAQYVN-------EVKRDNETLREIKQFQLSIENLNQPVLLFGRPQGDGEIRI 409

Query: 1300 I----GGKKDRSLFLF-TDLIVCTTLKRK 1323
                   K++R +FLF   +IVC   KRK
Sbjct: 410  TTLDKHTKQERHIFLFDLAVIVC---KRK 435


>gi|197304715 vav 2 guanine nucleotide exchange factor isoform 1 [Homo
            sapiens]
          Length = 878

 Score = 85.1 bits (209), Expect = 6e-16
 Identities = 72/271 (26%), Positives = 131/271 (48%), Gaps = 27/271 (9%)

Query: 1065 DMRKHVAMTLLDTEQSYVESLRTLMQGYMQPLKQPENSVLCDPSLVDEIFDQIPELLEHH 1124
            D R    + + +TE  Y  +L  + + YM PL+     ++  P+ +  +F  + +L++ H
Sbjct: 197  DKRNCCLLEIQETEAKYYRTLEDIEKNYMSPLR-----LVLSPADMAAVFINLEDLIKVH 251

Query: 1125 EQFLEQVRHCMQTWHAQQKVGALLVQSFS--KDVLVNIYSAYIDNFLNAKDAVRVAKEAR 1182
              FL  +   +         G+ L + F   K+ L+ IY  Y  +  +A++ +     +R
Sbjct: 252  HSFLRAIDVSVMVG------GSTLAKVFLDFKERLL-IYGEYCSHMEHAQNTLNQLLASR 304

Query: 1183 PAFLKFLEQ-SMRENKEKQALSDLMIKPVQRIPRYELLVKDLLKHTPEDHPDHPLLLEAQ 1241
              F + +E+ +++    K  L DL++ P+QR+ +Y LL+K+LL H+ E  P+   L EA 
Sbjct: 305  EDFRQKVEECTLKVQDGKFKLQDLLVVPMQRVLKYHLLLKELLSHSAE-RPERQQLKEAL 363

Query: 1242 RNIKQVAERINKGVRSAEEAERHARVLQEIEAHIEGMEDLQAPLRRFLRQEMVIEVKAIG 1301
              ++ +A  IN       E +R    L++I      +E+LQ  L  F R ++  E+K   
Sbjct: 364  EAMQDLAMYIN-------EVKRDKETLRKISEFQSSIENLQVKLEEFGRPKIDGELKVRS 416

Query: 1302 ----GKKDRSLFLFTDLIVCTTLKRKSGSLR 1328
                 K+DR LFLF  +++    K  S  L+
Sbjct: 417  IVNHTKQDRYLFLFDKVVIVCKRKGYSYELK 447


>gi|40549448 vav 2 guanine nucleotide exchange factor isoform 2 [Homo
            sapiens]
          Length = 839

 Score = 85.1 bits (209), Expect = 6e-16
 Identities = 72/271 (26%), Positives = 131/271 (48%), Gaps = 27/271 (9%)

Query: 1065 DMRKHVAMTLLDTEQSYVESLRTLMQGYMQPLKQPENSVLCDPSLVDEIFDQIPELLEHH 1124
            D R    + + +TE  Y  +L  + + YM PL+     ++  P+ +  +F  + +L++ H
Sbjct: 192  DKRNCCLLEIQETEAKYYRTLEDIEKNYMSPLR-----LVLSPADMAAVFINLEDLIKVH 246

Query: 1125 EQFLEQVRHCMQTWHAQQKVGALLVQSFS--KDVLVNIYSAYIDNFLNAKDAVRVAKEAR 1182
              FL  +   +         G+ L + F   K+ L+ IY  Y  +  +A++ +     +R
Sbjct: 247  HSFLRAIDVSVMVG------GSTLAKVFLDFKERLL-IYGEYCSHMEHAQNTLNQLLASR 299

Query: 1183 PAFLKFLEQ-SMRENKEKQALSDLMIKPVQRIPRYELLVKDLLKHTPEDHPDHPLLLEAQ 1241
              F + +E+ +++    K  L DL++ P+QR+ +Y LL+K+LL H+ E  P+   L EA 
Sbjct: 300  EDFRQKVEECTLKVQDGKFKLQDLLVVPMQRVLKYHLLLKELLSHSAE-RPERQQLKEAL 358

Query: 1242 RNIKQVAERINKGVRSAEEAERHARVLQEIEAHIEGMEDLQAPLRRFLRQEMVIEVKAIG 1301
              ++ +A  IN       E +R    L++I      +E+LQ  L  F R ++  E+K   
Sbjct: 359  EAMQDLAMYIN-------EVKRDKETLRKISEFQSSIENLQVKLEEFGRPKIDGELKVRS 411

Query: 1302 ----GKKDRSLFLFTDLIVCTTLKRKSGSLR 1328
                 K+DR LFLF  +++    K  S  L+
Sbjct: 412  IVNHTKQDRYLFLFDKVVIVCKRKGYSYELK 442


>gi|118150678 epithelial cell transforming sequence 2 oncogene-like
            [Homo sapiens]
          Length = 904

 Score = 80.9 bits (198), Expect = 1e-14
 Identities = 71/289 (24%), Positives = 127/289 (43%), Gaps = 21/289 (7%)

Query: 1061 KPQVDMRKHVAMTLLDTEQSYVESLRTLMQGYMQPLKQ--PENSVLCDPSLVDEIFDQIP 1118
            K   + R  V   LL +E+ YV+ L  +   Y+ PLK     N  +   + +  IF  I 
Sbjct: 561  KDSAEKRARVVRELLQSERKYVQILEIVRDVYVAPLKAALSSNRAILSAANIQIIFCDIL 620

Query: 1119 ELLEHHEQFLEQVRHCMQTWHAQQKVGALLVQSFSKDVLVNIYSAYIDNFLNAKDAVRVA 1178
            ++L  + QFL+ +R  +Q W     VG ++ +  S+   +N Y+ + +N+      +   
Sbjct: 621  QILSLNRQFLDNLRDRLQEWGPAHCVGEIVTKFGSQ---LNTYTNFFNNYPVILKTIEKC 677

Query: 1179 KEARPAFLKFLEQSMRENKEKQ-ALSDLMIKPVQRIPRYELLVKDLLKHTPEDHPDHPLL 1237
            +E  PAF  FL++  +    K  +L +L++ P +R   Y  L+  +  HTP +H D   L
Sbjct: 678  REMIPAFRTFLKRHDKTIVTKMLSLPELLLYPSRRFEEYLNLLYAVRLHTPAEHVDRGDL 737

Query: 1238 LEAQRNIKQVAERINKGVRSAEEAERHARVLQEIEAHIEGMEDLQAPLRRFLR------- 1290
              A   IK+    I++  ++    +     L +I+  I G   L    R  +R       
Sbjct: 738  TTAIDQIKKYKGYIDQMKQNITMKDH----LSDIQRIIWGCPTLSEVNRYLIRVQDVAQL 793

Query: 1291 ----QEMVIEVKAIGGKKDRSLFLFTDLIVCTTLKRKSGSLRRSSMSLY 1335
                +E+   ++      D SLFLF D ++ ++         R+S + Y
Sbjct: 794  HCCDEEISFSLRLYEHIHDLSLFLFNDALLVSSRGTSHTPFERTSKTTY 842


  Database: hs.faa
    Posted date:  Aug 4, 2009  4:42 PM
  Number of letters in database: 18,247,518
  Number of sequences in database:  37,866
  
Lambda     K      H
   0.313    0.131    0.393 

Gapped
Lambda     K      H
   0.267   0.0410    0.140 


Matrix: BLOSUM62
Gap Penalties: Existence: 11, Extension: 1
Number of Hits to DB: 101,516,570
Number of Sequences: 37866
Number of extensions: 6254827
Number of successful extensions: 42273
Number of sequences better than 10.0: 30
Number of HSP's better than 10.0 without gapping: 154
Number of HSP's successfully gapped in prelim test: 1299
Number of HSP's that attempted gapping in prelim test: 29328
Number of HSP's gapped (non-prelim): 13141
length of query: 2063
length of database: 18,247,518
effective HSP length: 118
effective length of query: 1945
effective length of database: 13,779,330
effective search space: 26800796850
effective search space used: 26800796850
T: 11
A: 40
X1: 16 ( 7.2 bits)
X2: 38 (14.6 bits)
X3: 64 (24.7 bits)
S1: 42 (21.9 bits)
S2: 70 (31.6 bits)
Search results were obtained with NCBI BLAST and RefSeq entries.