Search of human proteins with 21361340

Search of human proteins with 21361340

BLASTP 2.2.11 [Jun-05-2005]


Reference: Altschul, Stephen F., Thomas L. Madden, Alejandro A. Schaffer, 
Jinghui Zhang, Zheng Zhang, Webb Miller, and David J. Lipman (1997), 
"Gapped BLAST and PSI-BLAST: a new generation of protein database search
programs",  Nucleic Acids Res. 25:3389-3402.

Query= gi|21361340 glycogen synthase kinase 3 beta isoform 1 [Homo
sapiens]
         (433 letters)

Database: hs.faa 
           37,866 sequences; 18,247,518 total letters

Searching..................................................done

                                                                 Score    E
Sequences producing significant alignments:                      (bits) Value

gi|21361340 glycogen synthase kinase 3 beta isoform 1 [Homo sapi...   876   0.0  
gi|225903437 glycogen synthase kinase 3 beta isoform 2 [Homo sap...   840   0.0  
gi|49574532 glycogen synthase kinase 3 alpha [Homo sapiens]           620   e-177
gi|11496279 male germ cell-associated kinase [Homo sapiens]           175   6e-44
gi|4557439 cyclin-dependent kinase 3 [Homo sapiens]                   174   2e-43
gi|27477122 intestinal cell kinase [Homo sapiens]                     169   3e-42
gi|7662388 intestinal cell kinase [Homo sapiens]                      169   3e-42
gi|4502743 cyclin-dependent kinase 7 [Homo sapiens]                   169   5e-42
gi|91718897 mitogen-activated protein kinase 3 isoform 2 [Homo s...   165   7e-41
gi|91718899 mitogen-activated protein kinase 3 isoform 1 [Homo s...   165   7e-41
gi|16936528 cyclin-dependent kinase 2 isoform 1 [Homo sapiens]        165   8e-41
gi|4505569 cyclin-dependent kinase-like 2 [Homo sapiens]              165   8e-41
gi|57222269 cyclin-dependent kinase-like 4 [Homo sapiens]             162   6e-40
gi|37596297 cyclin-dependent kinase-like 1 [Homo sapiens]             162   7e-40
gi|83367069 cyclin-dependent kinase-like 5 [Homo sapiens]             161   9e-40
gi|4507281 cyclin-dependent kinase-like 5 [Homo sapiens]              161   9e-40
gi|4506085 mitogen-activated protein kinase 13 [Homo sapiens]         160   3e-39
gi|4826675 cyclin-dependent kinase 5 [Homo sapiens]                   158   8e-39
gi|20986497 mitogen-activated protein kinase 7 isoform 1 [Homo s...   158   1e-38
gi|209529736 mitogen-activated protein kinase 7 isoform 1 [Homo ...   158   1e-38
gi|209529734 mitogen-activated protein kinase 7 isoform 1 [Homo ...   158   1e-38
gi|20986531 mitogen-activated protein kinase 1 [Homo sapiens]         155   5e-38
gi|66932916 mitogen-activated protein kinase 1 [Homo sapiens]         155   5e-38
gi|20128774 mitogen-activated protein kinase 11 [Homo sapiens]        155   7e-38
gi|197333744 PCTAIRE protein kinase 1 isoform 2 [Homo sapiens]        154   2e-37
gi|5453860 PCTAIRE protein kinase 1 isoform 1 [Homo sapiens]          154   2e-37
gi|89903018 cell cycle related kinase isoform 3 [Homo sapiens]        153   3e-37
gi|95147356 mitogen-activated protein kinase 15 [Homo sapiens]        152   4e-37
gi|48255970 mitogen-activated protein kinase 12 [Homo sapiens]        152   7e-37
gi|21040235 PFTAIRE protein kinase 2 [Homo sapiens]                   152   7e-37

>gi|21361340 glycogen synthase kinase 3 beta isoform 1 [Homo
           sapiens]
          Length = 433

 Score =  876 bits (2263), Expect = 0.0
 Identities = 433/433 (100%), Positives = 433/433 (100%)

Query: 1   MSGRPRTTSFAESCKPVQQPSAFGSMKVSRDKDGSKVTTVVATPGQGPDRPQEVSYTDTK 60
           MSGRPRTTSFAESCKPVQQPSAFGSMKVSRDKDGSKVTTVVATPGQGPDRPQEVSYTDTK
Sbjct: 1   MSGRPRTTSFAESCKPVQQPSAFGSMKVSRDKDGSKVTTVVATPGQGPDRPQEVSYTDTK 60

Query: 61  VIGNGSFGVVYQAKLCDSGELVAIKKVLQDKRFKNRELQIMRKLDHCNIVRLRYFFYSSG 120
           VIGNGSFGVVYQAKLCDSGELVAIKKVLQDKRFKNRELQIMRKLDHCNIVRLRYFFYSSG
Sbjct: 61  VIGNGSFGVVYQAKLCDSGELVAIKKVLQDKRFKNRELQIMRKLDHCNIVRLRYFFYSSG 120

Query: 121 EKKDEVYLNLVLDYVPETVYRVARHYSRAKQTLPVIYVKLYMYQLFRSLAYIHSFGICHR 180
           EKKDEVYLNLVLDYVPETVYRVARHYSRAKQTLPVIYVKLYMYQLFRSLAYIHSFGICHR
Sbjct: 121 EKKDEVYLNLVLDYVPETVYRVARHYSRAKQTLPVIYVKLYMYQLFRSLAYIHSFGICHR 180

Query: 181 DIKPQNLLLDPDTAVLKLCDFGSAKQLVRGEPNVSYICSRYYRAPELIFGATDYTSSIDV 240
           DIKPQNLLLDPDTAVLKLCDFGSAKQLVRGEPNVSYICSRYYRAPELIFGATDYTSSIDV
Sbjct: 181 DIKPQNLLLDPDTAVLKLCDFGSAKQLVRGEPNVSYICSRYYRAPELIFGATDYTSSIDV 240

Query: 241 WSAGCVLAELLLGQPIFPGDSGVDQLVEIIKVLGTPTREQIREMNPNYTEFKFPQIKAHP 300
           WSAGCVLAELLLGQPIFPGDSGVDQLVEIIKVLGTPTREQIREMNPNYTEFKFPQIKAHP
Sbjct: 241 WSAGCVLAELLLGQPIFPGDSGVDQLVEIIKVLGTPTREQIREMNPNYTEFKFPQIKAHP 300

Query: 301 WTKDSSGTGHFTSGVRVFRPRTPPEAIALCSRLLEYTPTARLTPLEACAHSFFDELRDPN 360
           WTKDSSGTGHFTSGVRVFRPRTPPEAIALCSRLLEYTPTARLTPLEACAHSFFDELRDPN
Sbjct: 301 WTKDSSGTGHFTSGVRVFRPRTPPEAIALCSRLLEYTPTARLTPLEACAHSFFDELRDPN 360

Query: 361 VKLPNGRDTPALFNFTTQELSSNPPLATILIPPHARIQAAASTPTNATAASDANTGDRGQ 420
           VKLPNGRDTPALFNFTTQELSSNPPLATILIPPHARIQAAASTPTNATAASDANTGDRGQ
Sbjct: 361 VKLPNGRDTPALFNFTTQELSSNPPLATILIPPHARIQAAASTPTNATAASDANTGDRGQ 420

Query: 421 TNNAASASASNST 433
           TNNAASASASNST
Sbjct: 421 TNNAASASASNST 433


>gi|225903437 glycogen synthase kinase 3 beta isoform 2 [Homo
           sapiens]
          Length = 420

 Score =  840 bits (2170), Expect = 0.0
 Identities = 420/433 (96%), Positives = 420/433 (96%), Gaps = 13/433 (3%)

Query: 1   MSGRPRTTSFAESCKPVQQPSAFGSMKVSRDKDGSKVTTVVATPGQGPDRPQEVSYTDTK 60
           MSGRPRTTSFAESCKPVQQPSAFGSMKVSRDKDGSKVTTVVATPGQGPDRPQEVSYTDTK
Sbjct: 1   MSGRPRTTSFAESCKPVQQPSAFGSMKVSRDKDGSKVTTVVATPGQGPDRPQEVSYTDTK 60

Query: 61  VIGNGSFGVVYQAKLCDSGELVAIKKVLQDKRFKNRELQIMRKLDHCNIVRLRYFFYSSG 120
           VIGNGSFGVVYQAKLCDSGELVAIKKVLQDKRFKNRELQIMRKLDHCNIVRLRYFFYSSG
Sbjct: 61  VIGNGSFGVVYQAKLCDSGELVAIKKVLQDKRFKNRELQIMRKLDHCNIVRLRYFFYSSG 120

Query: 121 EKKDEVYLNLVLDYVPETVYRVARHYSRAKQTLPVIYVKLYMYQLFRSLAYIHSFGICHR 180
           EKKDEVYLNLVLDYVPETVYRVARHYSRAKQTLPVIYVKLYMYQLFRSLAYIHSFGICHR
Sbjct: 121 EKKDEVYLNLVLDYVPETVYRVARHYSRAKQTLPVIYVKLYMYQLFRSLAYIHSFGICHR 180

Query: 181 DIKPQNLLLDPDTAVLKLCDFGSAKQLVRGEPNVSYICSRYYRAPELIFGATDYTSSIDV 240
           DIKPQNLLLDPDTAVLKLCDFGSAKQLVRGEPNVSYICSRYYRAPELIFGATDYTSSIDV
Sbjct: 181 DIKPQNLLLDPDTAVLKLCDFGSAKQLVRGEPNVSYICSRYYRAPELIFGATDYTSSIDV 240

Query: 241 WSAGCVLAELLLGQPIFPGDSGVDQLVEIIKVLGTPTREQIREMNPNYTEFKFPQIKAHP 300
           WSAGCVLAELLLGQPIFPGDSGVDQLVEIIKVLGTPTREQIREMNPNYTEFKFPQIKAHP
Sbjct: 241 WSAGCVLAELLLGQPIFPGDSGVDQLVEIIKVLGTPTREQIREMNPNYTEFKFPQIKAHP 300

Query: 301 WTKDSSGTGHFTSGVRVFRPRTPPEAIALCSRLLEYTPTARLTPLEACAHSFFDELRDPN 360
           WTK             VFRPRTPPEAIALCSRLLEYTPTARLTPLEACAHSFFDELRDPN
Sbjct: 301 WTK-------------VFRPRTPPEAIALCSRLLEYTPTARLTPLEACAHSFFDELRDPN 347

Query: 361 VKLPNGRDTPALFNFTTQELSSNPPLATILIPPHARIQAAASTPTNATAASDANTGDRGQ 420
           VKLPNGRDTPALFNFTTQELSSNPPLATILIPPHARIQAAASTPTNATAASDANTGDRGQ
Sbjct: 348 VKLPNGRDTPALFNFTTQELSSNPPLATILIPPHARIQAAASTPTNATAASDANTGDRGQ 407

Query: 421 TNNAASASASNST 433
           TNNAASASASNST
Sbjct: 408 TNNAASASASNST 420


>gi|49574532 glycogen synthase kinase 3 alpha [Homo sapiens]
          Length = 483

 Score =  620 bits (1598), Expect = e-177
 Identities = 312/413 (75%), Positives = 346/413 (83%), Gaps = 14/413 (3%)

Query: 21  SAFGSMKVSRDKDGSKVTTVVATPGQGPDRPQEVSYTDTKVIGNGSFGVVYQAKLCDSGE 80
           ++F    V   +D  KVTTVVAT GQGP+R QEV+YTD KVIGNGSFGVVYQA+L ++ E
Sbjct: 84  TSFPPPGVKLGRDSGKVTTVVATLGQGPERSQEVAYTDIKVIGNGSFGVVYQARLAETRE 143

Query: 81  LVAIKKVLQDKRFKNRELQIMRKLDHCNIVRLRYFFYSSGEKKDEVYLNLVLDYVPETVY 140
           LVAIKKVLQDKRFKNRELQIMRKLDHCNIVRLRYFFYSSGEKKDE+YLNLVL+YVPETVY
Sbjct: 144 LVAIKKVLQDKRFKNRELQIMRKLDHCNIVRLRYFFYSSGEKKDELYLNLVLEYVPETVY 203

Query: 141 RVARHYSRAKQTLPVIYVKLYMYQLFRSLAYIHSFGICHRDIKPQNLLLDPDTAVLKLCD 200
           RVARH+++AK T+P++YVK+YMYQLFRSLAYIHS G+CHRDIKPQNLL+DPDTAVLKLCD
Sbjct: 204 RVARHFTKAKLTIPILYVKVYMYQLFRSLAYIHSQGVCHRDIKPQNLLVDPDTAVLKLCD 263

Query: 201 FGSAKQLVRGEPNVSYICSRYYRAPELIFGATDYTSSIDVWSAGCVLAELLLGQPIFPGD 260
           FGSAKQLVRGEPNVSYICSRYYRAPELIFGATDYTSSIDVWSAGCVLAELLLGQPIFPGD
Sbjct: 264 FGSAKQLVRGEPNVSYICSRYYRAPELIFGATDYTSSIDVWSAGCVLAELLLGQPIFPGD 323

Query: 261 SGVDQLVEIIKVLGTPTREQIREMNPNYTEFKFPQIKAHPWTKDSSGTGHFTSGVRVFRP 320
           SGVDQLVEIIKVLGTPTREQIREMNPNYTEFKFPQIKAHPWTK             VF+ 
Sbjct: 324 SGVDQLVEIIKVLGTPTREQIREMNPNYTEFKFPQIKAHPWTK-------------VFKS 370

Query: 321 RTPPEAIALCSRLLEYTPTARLTPLEACAHSFFDELRDPNVKLPNGRDTPALFNFTTQEL 380
           RTPPEAIALCS LLEYTP++RL+PLEACAHSFFDELR    +LPN R  P LFNF+  EL
Sbjct: 371 RTPPEAIALCSSLLEYTPSSRLSPLEACAHSFFDELRCLGTQLPNNRPLPPLFNFSAGEL 430

Query: 381 SSNPPLATILIPPHARIQAAASTPT-NATAASDANTGDRGQTNNAASASASNS 432
           S  P L  ILIPPH R  A  +T T ++ A ++  T    Q+ +A     ++S
Sbjct: 431 SIQPSLNAILIPPHLRSPAGTTTLTPSSQALTETPTSSDWQSTDATPTLTNSS 483


>gi|11496279 male germ cell-associated kinase [Homo sapiens]
          Length = 623

 Score =  175 bits (444), Expect = 6e-44
 Identities = 107/344 (31%), Positives = 186/344 (54%), Gaps = 38/344 (11%)

Query: 56  YTDTKVIGNGSFGVVYQAKLCDSGELVAIKKVLQ-----DKRFKNRELQIMRKLDHCNIV 110
           YT  + +G+G++G V   K  +SGELVAIK++ +     D+    RE++ ++KL+H N++
Sbjct: 4   YTTMRQLGDGTYGSVLMGKSNESGELVAIKRMKRKFYSWDECMNLREVKSLKKLNHANVI 63

Query: 111 RLRYFFYSSGEKKDEVYLNLVLDYVPETVYRVARHYSRAKQTLPVIYVKLYMYQLFRSLA 170
           +L+         ++  +L  + +Y+ E +Y++ +  ++     P   ++  MYQ+ + LA
Sbjct: 64  KLKEVI------RENDHLYFIFEYMKENLYQLMKDRNKL---FPESVIRNIMYQILQGLA 114

Query: 171 YIHSFGICHRDIKPQNLL-LDPDTAVLKLCDFGSAKQLVRGEPNVSYICSRYYRAPELIF 229
           +IH  G  HRD+KP+NLL + P+  ++K+ DFG A++L    P   Y+ +R+YRAPE++ 
Sbjct: 115 FIHKHGFFHRDMKPENLLCMGPE--LVKIADFGLARELRSQPPYTDYVSTRWYRAPEVLL 172

Query: 230 GATDYTSSIDVWSAGCVLAELLLGQPIFPGDSGVDQLVEIIKVLGTPTREQIRE--MNPN 287
            ++ Y+S IDVW+ G ++AEL + +P+FPG S VD++ +I +VLGTP +    E     +
Sbjct: 173 RSSVYSSPIDVWAVGSIMAELYMLRPLFPGTSEVDEIFKICQVLGTPKKSDWPEGYQLAS 232

Query: 288 YTEFKFPQIKAHPWTKDSSGTGHFTSGVRVFRPRTPPEAIALCSRLLEYTPTARLTPLEA 347
              F+FPQ                   ++   P    EAI L + +L + P  R T  +A
Sbjct: 233 SMNFRFPQC--------------VPINLKTLIPNASNEAIQLMTEMLNWDPKKRPTASQA 278

Query: 348 CAHSFFD--ELRDPNVKLPNGRDTPALFNFTTQELSSNPPLATI 389
             H +F   ++  P+    N  ++    N   Q L S P L  +
Sbjct: 279 LKHPYFQVGQVLGPS---SNHLESKQSLNKQLQPLESKPSLVEV 319


>gi|4557439 cyclin-dependent kinase 3 [Homo sapiens]
          Length = 305

 Score =  174 bits (440), Expect = 2e-43
 Identities = 104/301 (34%), Positives = 172/301 (57%), Gaps = 33/301 (10%)

Query: 62  IGNGSFGVVYQAKLCDSGELVAIKKVLQDKRFKN------RELQIMRKLDHCNIVRLRYF 115
           IG G++GVVY+AK  ++G+LVA+KK+  D   +       RE+ ++++L H NIVRL   
Sbjct: 10  IGEGTYGVVYKAKNRETGQLVALKKIRLDLEMEGVPSTAIREISLLKELKHPNIVRLLDV 69

Query: 116 FYSSGEKKDEVYLNLVLDYVPETVYRVARHYSRAKQTLPVIYVKLYMYQLFRSLAYIHSF 175
            ++  E+K    L LV +++ + + +     S     LP+  +K Y++QL + +++ HS 
Sbjct: 70  VHN--ERK----LYLVFEFLSQDLKKYMD--STPGSELPLHLIKSYLFQLLQGVSFCHSH 121

Query: 176 GICHRDIKPQNLLLDPDTAVLKLCDFGSAKQLVRGEPNVSY---ICSRYYRAPELIFGAT 232
            + HRD+KPQNLL++ +   +KL DFG A+    G P  +Y   + + +YRAPE++ G+ 
Sbjct: 122 RVIHRDLKPQNLLIN-ELGAIKLADFGLARAF--GVPLRTYTHEVVTLWYRAPEILLGSK 178

Query: 233 DYTSSIDVWSAGCVLAELLLGQPIFPGDSGVDQLVEIIKVLGTPTREQIREMNPNYTEFK 292
            YT+++D+WS GC+ AE++  + +FPGDS +DQL  I ++LGTP+ +      P  T+  
Sbjct: 179 FYTTAVDIWSIGCIFAEMVTRKALFPGDSEIDQLFRIFRMLGTPSEDTW----PGVTQLP 234

Query: 293 FPQIKAHPWTKDSSGTGHFTSGVRVFRPRTPPEAIALCSRLLEYTPTARLTPLEACAHSF 352
             +     WT+          G+    P   PE   L  +LL+Y P+ R+T   A AH +
Sbjct: 235 DYKGSFPKWTR---------KGLEEIVPNLEPEGRDLLMQLLQYDPSQRITAKTALAHPY 285

Query: 353 F 353
           F
Sbjct: 286 F 286


>gi|27477122 intestinal cell kinase [Homo sapiens]
          Length = 632

 Score =  169 bits (429), Expect = 3e-42
 Identities = 94/306 (30%), Positives = 173/306 (56%), Gaps = 33/306 (10%)

Query: 56  YTDTKVIGNGSFGVVYQAKLCDSGELVAIKKVLQ-----DKRFKNRELQIMRKLDHCNIV 110
           YT  + +G+G++G V   +  +SGEL+AIKK+ +     ++    RE++ ++KL+H N+V
Sbjct: 4   YTTIRQLGDGTYGSVLLGRSIESGELIAIKKMKRKFYSWEECMNLREVKSLKKLNHANVV 63

Query: 111 RLRYFFYSSGEKKDEVYLNLVLDYVPETVYRVARHYSRAKQTLPVIYVKLYMYQLFRSLA 170
           +L+         ++  +L  + +Y+ E +Y++ +  ++     P   ++  MYQ+ + LA
Sbjct: 64  KLKEVI------RENDHLYFIFEYMKENLYQLIKERNKL---FPESAIRNIMYQILQGLA 114

Query: 171 YIHSFGICHRDIKPQNLL-LDPDTAVLKLCDFGSAKQLVRGEPNVSYICSRYYRAPELIF 229
           +IH  G  HRD+KP+NLL + P+  ++K+ DFG A+++    P   Y+ +R+YRAPE++ 
Sbjct: 115 FIHKHGFFHRDLKPENLLCMGPE--LVKIADFGLAREIRSKPPYTDYVSTRWYRAPEVLL 172

Query: 230 GATDYTSSIDVWSAGCVLAELLLGQPIFPGDSGVDQLVEIIKVLGTPTREQIRE--MNPN 287
            +T+Y+S IDVW+ GC++AE+   +P+FPG S +D + +I +VLGTP +    E     +
Sbjct: 173 RSTNYSSPIDVWAVGCIMAEVYTLRPLFPGASEIDTIFKICQVLGTPKKTDWPEGYQLSS 232

Query: 288 YTEFKFPQIKAHPWTKDSSGTGHFTSGVRVFRPRTPPEAIALCSRLLEYTPTARLTPLEA 347
              F++PQ                 + ++   P    EA+ L   +L++ P  R T  +A
Sbjct: 233 AMNFRWPQC--------------VPNNLKTLIPNASSEAVQLLRDMLQWDPKKRPTASQA 278

Query: 348 CAHSFF 353
             + +F
Sbjct: 279 LRYPYF 284


>gi|7662388 intestinal cell kinase [Homo sapiens]
          Length = 632

 Score =  169 bits (429), Expect = 3e-42
 Identities = 94/306 (30%), Positives = 173/306 (56%), Gaps = 33/306 (10%)

Query: 56  YTDTKVIGNGSFGVVYQAKLCDSGELVAIKKVLQ-----DKRFKNRELQIMRKLDHCNIV 110
           YT  + +G+G++G V   +  +SGEL+AIKK+ +     ++    RE++ ++KL+H N+V
Sbjct: 4   YTTIRQLGDGTYGSVLLGRSIESGELIAIKKMKRKFYSWEECMNLREVKSLKKLNHANVV 63

Query: 111 RLRYFFYSSGEKKDEVYLNLVLDYVPETVYRVARHYSRAKQTLPVIYVKLYMYQLFRSLA 170
           +L+         ++  +L  + +Y+ E +Y++ +  ++     P   ++  MYQ+ + LA
Sbjct: 64  KLKEVI------RENDHLYFIFEYMKENLYQLIKERNKL---FPESAIRNIMYQILQGLA 114

Query: 171 YIHSFGICHRDIKPQNLL-LDPDTAVLKLCDFGSAKQLVRGEPNVSYICSRYYRAPELIF 229
           +IH  G  HRD+KP+NLL + P+  ++K+ DFG A+++    P   Y+ +R+YRAPE++ 
Sbjct: 115 FIHKHGFFHRDLKPENLLCMGPE--LVKIADFGLAREIRSKPPYTDYVSTRWYRAPEVLL 172

Query: 230 GATDYTSSIDVWSAGCVLAELLLGQPIFPGDSGVDQLVEIIKVLGTPTREQIRE--MNPN 287
            +T+Y+S IDVW+ GC++AE+   +P+FPG S +D + +I +VLGTP +    E     +
Sbjct: 173 RSTNYSSPIDVWAVGCIMAEVYTLRPLFPGASEIDTIFKICQVLGTPKKTDWPEGYQLSS 232

Query: 288 YTEFKFPQIKAHPWTKDSSGTGHFTSGVRVFRPRTPPEAIALCSRLLEYTPTARLTPLEA 347
              F++PQ                 + ++   P    EA+ L   +L++ P  R T  +A
Sbjct: 233 AMNFRWPQC--------------VPNNLKTLIPNASSEAVQLLRDMLQWDPKKRPTASQA 278

Query: 348 CAHSFF 353
             + +F
Sbjct: 279 LRYPYF 284


>gi|4502743 cyclin-dependent kinase 7 [Homo sapiens]
          Length = 346

 Score =  169 bits (428), Expect = 5e-42
 Identities = 115/319 (36%), Positives = 164/319 (51%), Gaps = 44/319 (13%)

Query: 56  YTDTKVIGNGSFGVVYQAKLCDSGELVAIKKVLQDKRFKN---------RELQIMRKLDH 106
           Y     +G G F  VY+A+  ++ ++VAIKK+    R +          RE++++++L H
Sbjct: 12  YEKLDFLGEGQFATVYKARDKNTNQIVAIKKIKLGHRSEAKDGINRTALREIKLLQELSH 71

Query: 107 CNIVRLRYFFYSSGEKKDEVYLNLVLDYVPETVYRVARHYSRAKQTLPVIYVKLYMYQLF 166
            NI+ L   F   G K +   ++LV D++   +  + +  S     L   ++K YM    
Sbjct: 72  PNIIGLLDAF---GHKSN---ISLVFDFMETDLEVIIKDNSLV---LTPSHIKAYMLMTL 122

Query: 167 RSLAYIHSFGICHRDIKPQNLLLDPDTAVLKLCDFGSAKQLVRGEPNVSY---ICSRYYR 223
           + L Y+H   I HRD+KP NLLLD +  VLKL DFG AK    G PN +Y   + +R+YR
Sbjct: 123 QGLEYLHQHWILHRDLKPNNLLLD-ENGVLKLADFGLAKSF--GSPNRAYTHQVVTRWYR 179

Query: 224 APELIFGATDYTSSIDVWSAGCVLAELLLGQPIFPGDSGVDQLVEIIKVLGTPTREQIRE 283
           APEL+FGA  Y   +D+W+ GC+LAELLL  P  PGDS +DQL  I + LGTPT EQ  +
Sbjct: 180 APELLFGARMYGVGVDMWAVGCILAELLLRVPFLPGDSDLDQLTRIFETLGTPTEEQWPD 239

Query: 284 M--NPNYTEFK-FPQIKAHPWTKDSSGTGHFTSGVRVFRPRTPPEAIALCSRLLEYTPTA 340
           M   P+Y  FK FP I  H          H  S           + + L   L  + P A
Sbjct: 240 MCSLPDYVTFKSFPGIPLH----------HIFSA-------AGDDLLDLIQGLFLFNPCA 282

Query: 341 RLTPLEACAHSFFDELRDP 359
           R+T  +A    +F     P
Sbjct: 283 RITATQALKMKYFSNRPGP 301


>gi|91718897 mitogen-activated protein kinase 3 isoform 2 [Homo
           sapiens]
          Length = 357

 Score =  165 bits (418), Expect = 7e-41
 Identities = 113/343 (32%), Positives = 174/343 (50%), Gaps = 49/343 (14%)

Query: 43  TPGQGPDRPQEVS------------YTDTKVIGNGSFGVVYQAKLCDSGELVAIKKV--L 88
           T G GP  P EV             YT  + IG G++G+V  A        VAIKK+   
Sbjct: 17  TEGVGPGVPGEVEMVKGQPFDVGPRYTQLQYIGEGAYGMVSSAYDHVRKTRVAIKKISPF 76

Query: 89  QDKRFKNR---ELQIMRKLDHCNIVRLRYFFYSSG-EKKDEVYLNLVLDYVPETVYRVAR 144
           + + +  R   E+QI+ +  H N++ +R    +S  E   +VY+  V D +   +Y++ +
Sbjct: 77  EHQTYCQRTLREIQILLRFRHENVIGIRDILRASTLEAMRDVYI--VQDLMETDLYKLLK 134

Query: 145 HYSRAKQTLPVIYVKLYMYQLFRSLAYIHSFGICHRDIKPQNLLLDPDTAVLKLCDFGSA 204
                 Q L   ++  ++YQ+ R L YIHS  + HRD+KP NLL++  T  LK+CDFG A
Sbjct: 135 -----SQQLSNDHICYFLYQILRGLKYIHSANVLHRDLKPSNLLINT-TCDLKICDFGLA 188

Query: 205 KQLVRGEPNVS----YICSRYYRAPELIFGATDYTSSIDVWSAGCVLAELLLGQPIFPGD 260
           +       +      Y+ +R+YRAPE++  +  YT SID+WS GC+LAE+L  +PIFPG 
Sbjct: 189 RIADPEHDHTGFLTEYVATRWYRAPEIMLNSKGYTKSIDIWSVGCILAEMLSNRPIFPGK 248

Query: 261 SGVDQLVEIIKVLGTPTREQ----IREMNPNYTEFKFPQIKAHPWTKDSSGTGHFTSGVR 316
             +DQL  I+ +LG+P++E     I     NY +   P      W K             
Sbjct: 249 HYLDQLNHILGILGSPSQEDLNCIINMKARNYLQ-SLPSKTKVAWAK------------- 294

Query: 317 VFRPRTPPEAIALCSRLLEYTPTARLTPLEACAHSFFDELRDP 359
              P++  +A+ L  R+L + P  R+T  EA AH + ++  DP
Sbjct: 295 -LFPKSDSKALDLLDRMLTFNPNKRITVEEALAHPYLEQYYDP 336


>gi|91718899 mitogen-activated protein kinase 3 isoform 1 [Homo
           sapiens]
          Length = 379

 Score =  165 bits (418), Expect = 7e-41
 Identities = 113/343 (32%), Positives = 174/343 (50%), Gaps = 49/343 (14%)

Query: 43  TPGQGPDRPQEVS------------YTDTKVIGNGSFGVVYQAKLCDSGELVAIKKV--L 88
           T G GP  P EV             YT  + IG G++G+V  A        VAIKK+   
Sbjct: 17  TEGVGPGVPGEVEMVKGQPFDVGPRYTQLQYIGEGAYGMVSSAYDHVRKTRVAIKKISPF 76

Query: 89  QDKRFKNR---ELQIMRKLDHCNIVRLRYFFYSSG-EKKDEVYLNLVLDYVPETVYRVAR 144
           + + +  R   E+QI+ +  H N++ +R    +S  E   +VY+  V D +   +Y++ +
Sbjct: 77  EHQTYCQRTLREIQILLRFRHENVIGIRDILRASTLEAMRDVYI--VQDLMETDLYKLLK 134

Query: 145 HYSRAKQTLPVIYVKLYMYQLFRSLAYIHSFGICHRDIKPQNLLLDPDTAVLKLCDFGSA 204
                 Q L   ++  ++YQ+ R L YIHS  + HRD+KP NLL++  T  LK+CDFG A
Sbjct: 135 -----SQQLSNDHICYFLYQILRGLKYIHSANVLHRDLKPSNLLINT-TCDLKICDFGLA 188

Query: 205 KQLVRGEPNVS----YICSRYYRAPELIFGATDYTSSIDVWSAGCVLAELLLGQPIFPGD 260
           +       +      Y+ +R+YRAPE++  +  YT SID+WS GC+LAE+L  +PIFPG 
Sbjct: 189 RIADPEHDHTGFLTEYVATRWYRAPEIMLNSKGYTKSIDIWSVGCILAEMLSNRPIFPGK 248

Query: 261 SGVDQLVEIIKVLGTPTREQ----IREMNPNYTEFKFPQIKAHPWTKDSSGTGHFTSGVR 316
             +DQL  I+ +LG+P++E     I     NY +   P      W K             
Sbjct: 249 HYLDQLNHILGILGSPSQEDLNCIINMKARNYLQ-SLPSKTKVAWAK------------- 294

Query: 317 VFRPRTPPEAIALCSRLLEYTPTARLTPLEACAHSFFDELRDP 359
              P++  +A+ L  R+L + P  R+T  EA AH + ++  DP
Sbjct: 295 -LFPKSDSKALDLLDRMLTFNPNKRITVEEALAHPYLEQYYDP 336


>gi|16936528 cyclin-dependent kinase 2 isoform 1 [Homo sapiens]
          Length = 298

 Score =  165 bits (417), Expect = 8e-41
 Identities = 104/318 (32%), Positives = 176/318 (55%), Gaps = 41/318 (12%)

Query: 55  SYTDTKVIGNGSFGVVYQAKLCDSGELVAIKKVLQDKRFKN------RELQIMRKLDHCN 108
           ++   + IG G++GVVY+A+   +GE+VA+KK+  D   +       RE+ ++++L+H N
Sbjct: 3   NFQKVEKIGEGTYGVVYKARNKLTGEVVALKKIRLDTETEGVPSTAIREISLLKELNHPN 62

Query: 109 IVRLRYFFYSSGEKKDEVYLNLVLDYVPETVYRVARHYSRAKQTLPVIYVKLYMYQLFRS 168
           IV+L    ++  +      L LV +++ + + +     + A   +P+  +K Y++QL + 
Sbjct: 63  IVKLLDVIHTENK------LYLVFEFLHQDLKKFMD--ASALTGIPLPLIKSYLFQLLQG 114

Query: 169 LAYIHSFGICHRDIKPQNLLLDPDTAVLKLCDFGSAKQLVRGEPNVSY---ICSRYYRAP 225
           LA+ HS  + HRD+KPQNLL++ + A+ KL DFG A+    G P  +Y   + + +YRAP
Sbjct: 115 LAFCHSHRVLHRDLKPQNLLINTEGAI-KLADFGLARAF--GVPVRTYTHEVVTLWYRAP 171

Query: 226 ELIFGATDYTSSIDVWSAGCVLAELLLGQPIFPGDSGVDQLVEIIKVLGTPTREQIREMN 285
           E++ G   Y++++D+WS GC+ AE++  + +FPGDS +DQL  I + LGTP         
Sbjct: 172 EILLGCKYYSTAVDIWSLGCIFAEMVTRRALFPGDSEIDQLFRIFRTLGTP--------- 222

Query: 286 PNYTEFKFPQIKAHPWTKDSSGTGHFTSGVRV-FRPRTPP---EAIALCSRLLEYTPTAR 341
               E  +P + + P  K S     F    R  F    PP   +  +L S++L Y P  R
Sbjct: 223 ---DEVVWPGVTSMPDYKPS-----FPKWARQDFSKVVPPLDEDGRSLLSQMLHYDPNKR 274

Query: 342 LTPLEACAHSFFDELRDP 359
           ++   A AH FF ++  P
Sbjct: 275 ISAKAALAHPFFQDVTKP 292


>gi|4505569 cyclin-dependent kinase-like 2 [Homo sapiens]
          Length = 493

 Score =  165 bits (417), Expect = 8e-41
 Identities = 100/307 (32%), Positives = 159/307 (51%), Gaps = 32/307 (10%)

Query: 56  YTDTKVIGNGSFGVVYQAKLCDSGELVAIKKVLQD------KRFKNRELQIMRKLDHCNI 109
           Y +  ++G GS+G+V + +  D+G +VAIKK L+       K+   RE++++++L H N+
Sbjct: 4   YENLGLVGEGSYGMVMKCRNKDTGRIVAIKKFLESDDDKMVKKIAMREIKLLKQLRHENL 63

Query: 110 VRLRYFFYSSGEKKDEVYLNLVLDYVPETVYRVARHYSRAKQTLPVIYVKLYMYQLFRSL 169
           V L        +KK   YL  V ++V  T+      +      L    V+ Y++Q+   +
Sbjct: 64  VNL----LEVCKKKKRWYL--VFEFVDHTILDDLELFPNG---LDYQVVQKYLFQIINGI 114

Query: 170 AYIHSFGICHRDIKPQNLLLDPDTAVLKLCDFGSAKQLVR-GEPNVSYICSRYYRAPELI 228
            + HS  I HRDIKP+N+L+   + V+KLCDFG A+ L   GE    Y+ +R+YRAPEL+
Sbjct: 115 GFCHSHNIIHRDIKPENILVS-QSGVVKLCDFGFARTLAAPGEVYTDYVATRWYRAPELL 173

Query: 229 FGATDYTSSIDVWSAGCVLAELLLGQPIFPGDSGVDQLVEIIKVLGT--PTREQIREMNP 286
            G   Y  ++DVW+ GC++ E+ +G+P+FPGDS +DQL  I+  LG   P  +++   NP
Sbjct: 174 VGDVKYGKAVDVWAIGCLVTEMFMGEPLFPGDSDIDQLYHIMMCLGNLIPRHQELFNKNP 233

Query: 287 NYTEFKFPQIKAHPWTKDSSGTGHFTSGVRVFRPRTPPEAIALCSRLLEYTPTARLTPLE 346
            +   + P+IK                 +    P+     I L  + L   P  R    E
Sbjct: 234 VFAGVRLPEIKER-------------EPLERRYPKLSEVVIDLAKKCLHIDPDKRPFCAE 280

Query: 347 ACAHSFF 353
              H FF
Sbjct: 281 LLHHDFF 287


>gi|57222269 cyclin-dependent kinase-like 4 [Homo sapiens]
          Length = 315

 Score =  162 bits (410), Expect = 6e-40
 Identities = 98/308 (31%), Positives = 160/308 (51%), Gaps = 31/308 (10%)

Query: 63  GNGSFGVVYQAKLCDSGELVAIKKVLQD------KRFKNRELQIMRKLDHCNIVRLRYFF 116
           G GS+GVV++ +   SG++VA+KK ++       K+   RE++++++L H N+V L   F
Sbjct: 11  GEGSYGVVFKCRNKTSGQVVAVKKFVESEDDPVVKKIALREIRMLKQLKHPNLVNLIEVF 70

Query: 117 YSSGEKKDEVYLNLVLDYVPETVYRVARHYSRAKQTLPVIYVKLYMYQLFRSLAYIHSFG 176
               +      ++LV +Y   T+        R    +    +K  ++Q  ++L + H   
Sbjct: 71  RRKRK------MHLVFEYCDHTLLN---ELERNPNGVADGVIKSVLWQTLQALNFCHIHN 121

Query: 177 ICHRDIKPQNLLLDPDTAVLKLCDFGSAKQLVRGEPNVSYICSRYYRAPELIFGATDYTS 236
             HRDIKP+N+L+     ++K+CDFG A+ L+ G+    Y+ +R+YRAPEL+ G T Y S
Sbjct: 122 CIHRDIKPENILITKQ-GIIKICDFGFAQILIPGDAYTDYVATRWYRAPELLVGDTQYGS 180

Query: 237 SIDVWSAGCVLAELLLGQPIFPGDSGVDQLVEIIKVLG--TPTREQIREMNPNYTEFKFP 294
           S+D+W+ GCV AELL GQP++PG S VDQL  II+ LG   P  + I + N  +     P
Sbjct: 181 SVDIWAIGCVFAELLTGQPLWPGKSDVDQLYLIIRTLGKLIPRHQSIFKSNGFFHGISIP 240

Query: 295 QIKAHPWTKDSSGTGHFTSGVRVFRPRTPPEAIALCSRLLEYTPTARLTPLEACAHSFFD 354
           + +     ++     H             P A+      L+  P  RLT  +    S+FD
Sbjct: 241 EPEDMETLEEKFSDVH-------------PVALNFMKGCLKMNPDDRLTCSQLLESSYFD 287

Query: 355 ELRDPNVK 362
             ++  +K
Sbjct: 288 SFQEAQIK 295


>gi|37596297 cyclin-dependent kinase-like 1 [Homo sapiens]
          Length = 358

 Score =  162 bits (409), Expect = 7e-40
 Identities = 103/306 (33%), Positives = 159/306 (51%), Gaps = 32/306 (10%)

Query: 62  IGNGSFGVVYQAKLCDSGELVAIKKVLQD------KRFKNRELQIMRKLDHCNIVRLRYF 115
           IG GS+GVV++ +  D+G++VAIKK L+       K+   RE++++++L H N+V L   
Sbjct: 11  IGEGSYGVVFKCRNRDTGQIVAIKKFLESEDDPVIKKIALREIRMLKQLKHPNLVNLLEV 70

Query: 116 FYSSGEKKDEVYLNLVLDYVPETVYRVARHYSRAKQTLPVIYVKLYMYQLFRSLAYIHSF 175
           F      + +  L+LV +Y   TV      Y R    +P   VK   +Q  +++ + H  
Sbjct: 71  F------RRKRRLHLVFEYCDHTVLHELDRYQRG---VPEHLVKSITWQTLQAVNFCHKH 121

Query: 176 GICHRDIKPQNLLLDPDTAVLKLCDFGSAKQLVR-GEPNVSYICSRYYRAPELIFGATDY 234
              HRD+KP+N+L+   + V+KLCDFG A+ L    +    Y+ +R+YR+PEL+ G T Y
Sbjct: 122 NCIHRDVKPENILITKHS-VIKLCDFGFARLLTGPSDYYTDYVATRWYRSPELLVGDTQY 180

Query: 235 TSSIDVWSAGCVLAELLLGQPIFPGDSGVDQLVEIIKVLG--TPTREQIREMNPNYTEFK 292
              +DVW+ GCV AELL G P++PG S VDQL  I K LG   P  +Q+   N  ++  K
Sbjct: 181 GPPVDVWAIGCVFAELLSGVPLWPGKSDVDQLYLIRKTLGDLIPRHQQVFSTNQYFSGVK 240

Query: 293 FPQIKAHPWTKDSSGTGHFTSGVRVFRPRTPPEAIALCSRLLEYTPTARLTPLEACAHSF 352
            P  +                 + +  P     A+ L    L   PT RLT  +   H +
Sbjct: 241 IPDPED-------------MEPLELKFPNISYPALGLLKGCLHMDPTQRLTCEQLLHHPY 287

Query: 353 FDELRD 358
           F+ +R+
Sbjct: 288 FENIRE 293


>gi|83367069 cyclin-dependent kinase-like 5 [Homo sapiens]
          Length = 1030

 Score =  161 bits (408), Expect = 9e-40
 Identities = 109/307 (35%), Positives = 160/307 (52%), Gaps = 33/307 (10%)

Query: 61  VIGNGSFGVVYQAKLCDSGELVAIKKVLQDKRFKN------RELQIMRKLDHCNIVRLRY 114
           V+G G++GVV + +  ++ E+VAIKK    +  +       REL+++R L   NIV L+ 
Sbjct: 18  VVGEGAYGVVLKCRHKETHEIVAIKKFKDSEENEEVKETTLRELKMLRTLKQENIVELKE 77

Query: 115 FFYSSGEKKDEVYLNLVLDYVPETVYRVARHYSRAKQTLPVIYVKLYMYQLFRSLAYIHS 174
            F   G+      L LV +YV + +  +          +P   VK Y+YQL +++ + H 
Sbjct: 78  AFRRRGK------LYLVFEYVEKNMLELLEEMPNG---VPPEKVKSYIYQLIKAIHWCHK 128

Query: 175 FGICHRDIKPQNLLLDPDTAVLKLCDFGSAKQLVRGEPN--VSYICSRYYRAPELIFGAT 232
             I HRDIKP+NLL+  +  VLKLCDFG A+ L  G       Y+ +R+YR+PEL+ GA 
Sbjct: 129 NDIVHRDIKPENLLISHND-VLKLCDFGFARNLSEGNNANYTEYVATRWYRSPELLLGAP 187

Query: 233 DYTSSIDVWSAGCVLAELLLGQPIFPGDSGVDQLVEIIKVLGTPTREQIR--EMNPNYTE 290
            Y  S+D+WS GC+L EL  GQP+FPG+S +DQL  I KVLG    EQ++    NP +  
Sbjct: 188 -YGKSVDMWSVGCILGELSDGQPLFPGESEIDQLFTIQKVLGPLPSEQMKLFYSNPRFHG 246

Query: 291 FKFPQIKAHPWTKDSSGTGHFTSGVRVFRPRTPPEAIALCSRLLEYTPTARLTPLEACAH 350
            +FP +  HP + +    G   S +           + L   LL+  P  R    +   H
Sbjct: 247 LRFPAVN-HPQSLERRYLGILNSVL-----------LDLMKNLLKLDPADRYLTEQCLNH 294

Query: 351 SFFDELR 357
             F   R
Sbjct: 295 PTFQTQR 301


>gi|4507281 cyclin-dependent kinase-like 5 [Homo sapiens]
          Length = 1030

 Score =  161 bits (408), Expect = 9e-40
 Identities = 109/307 (35%), Positives = 160/307 (52%), Gaps = 33/307 (10%)

Query: 61  VIGNGSFGVVYQAKLCDSGELVAIKKVLQDKRFKN------RELQIMRKLDHCNIVRLRY 114
           V+G G++GVV + +  ++ E+VAIKK    +  +       REL+++R L   NIV L+ 
Sbjct: 18  VVGEGAYGVVLKCRHKETHEIVAIKKFKDSEENEEVKETTLRELKMLRTLKQENIVELKE 77

Query: 115 FFYSSGEKKDEVYLNLVLDYVPETVYRVARHYSRAKQTLPVIYVKLYMYQLFRSLAYIHS 174
            F   G+      L LV +YV + +  +          +P   VK Y+YQL +++ + H 
Sbjct: 78  AFRRRGK------LYLVFEYVEKNMLELLEEMPNG---VPPEKVKSYIYQLIKAIHWCHK 128

Query: 175 FGICHRDIKPQNLLLDPDTAVLKLCDFGSAKQLVRGEPN--VSYICSRYYRAPELIFGAT 232
             I HRDIKP+NLL+  +  VLKLCDFG A+ L  G       Y+ +R+YR+PEL+ GA 
Sbjct: 129 NDIVHRDIKPENLLISHND-VLKLCDFGFARNLSEGNNANYTEYVATRWYRSPELLLGAP 187

Query: 233 DYTSSIDVWSAGCVLAELLLGQPIFPGDSGVDQLVEIIKVLGTPTREQIR--EMNPNYTE 290
            Y  S+D+WS GC+L EL  GQP+FPG+S +DQL  I KVLG    EQ++    NP +  
Sbjct: 188 -YGKSVDMWSVGCILGELSDGQPLFPGESEIDQLFTIQKVLGPLPSEQMKLFYSNPRFHG 246

Query: 291 FKFPQIKAHPWTKDSSGTGHFTSGVRVFRPRTPPEAIALCSRLLEYTPTARLTPLEACAH 350
            +FP +  HP + +    G   S +           + L   LL+  P  R    +   H
Sbjct: 247 LRFPAVN-HPQSLERRYLGILNSVL-----------LDLMKNLLKLDPADRYLTEQCLNH 294

Query: 351 SFFDELR 357
             F   R
Sbjct: 295 PTFQTQR 301


>gi|4506085 mitogen-activated protein kinase 13 [Homo sapiens]
          Length = 365

 Score =  160 bits (404), Expect = 3e-39
 Identities = 101/312 (32%), Positives = 162/312 (51%), Gaps = 28/312 (8%)

Query: 55  SYTDTKVIGNGSFGVVYQAKLCDSGELVAIKKV---LQDKRFKNR---ELQIMRKLDHCN 108
           +Y     +G+G++G V  A    SGE VAIKK+    Q + F  R   EL +++ + H N
Sbjct: 24  TYVSPTHVGSGAYGSVCSAIDKRSGEKVAIKKLSRPFQSEIFAKRAYRELLLLKHMQHEN 83

Query: 109 IVRLRYFFYSSGEKKDEVYLNLVLDYVPETVYRV-ARHYSRAKQTLPVIYVKLYMYQLFR 167
           ++ L   F  +   ++     LV+ ++   + ++    +S  K       ++  +YQ+ +
Sbjct: 84  VIGLLDVFTPASSLRNFYDFYLVMPFMQTDLQKIMGMEFSEEK-------IQYLVYQMLK 136

Query: 168 SLAYIHSFGICHRDIKPQNLLLDPDTAVLKLCDFGSAKQLVRGEPNVSYICSRYYRAPEL 227
            L YIHS G+ HRD+KP NL ++ D   LK+ DFG A+          Y+ +R+YRAPE+
Sbjct: 137 GLKYIHSAGVVHRDLKPGNLAVNEDCE-LKILDFGLARHA--DAEMTGYVVTRWYRAPEV 193

Query: 228 IFGATDYTSSIDVWSAGCVLAELLLGQPIFPGDSGVDQLVEIIKVLGTPTREQIREMNPN 287
           I     Y  ++D+WS GC++AE+L G+ +F G   +DQL +I+KV G P  E ++++N  
Sbjct: 194 ILSWMHYNQTVDIWSVGCIMAEMLTGKTLFKGKDYLDQLTQILKVTGVPGTEFVQKLNDK 253

Query: 288 YTEFKFPQIKAHPWTKDSSGTGHFTSGVRVFRPRTPPEAIALCSRLLEYTPTARLTPLEA 347
             +     I++ P T     T  F        PR  P+A  L  ++LE     RLT  +A
Sbjct: 254 AAK---SYIQSLPQTPRKDFTQLF--------PRASPQAADLLEKMLELDVDKRLTAAQA 302

Query: 348 CAHSFFDELRDP 359
             H FF+  RDP
Sbjct: 303 LTHPFFEPFRDP 314


>gi|4826675 cyclin-dependent kinase 5 [Homo sapiens]
          Length = 292

 Score =  158 bits (400), Expect = 8e-39
 Identities = 110/314 (35%), Positives = 169/314 (53%), Gaps = 35/314 (11%)

Query: 56  YTDTKVIGNGSFGVVYQAKLCDSGELVAIKKVLQDKRFKN------RELQIMRKLDHCNI 109
           Y   + IG G++G V++AK  ++ E+VA+K+V  D   +       RE+ ++++L H NI
Sbjct: 4   YEKLEKIGEGTYGTVFKAKNRETHEIVALKRVRLDDDDEGVPSSALREICLLKELKHKNI 63

Query: 110 VRLRYFFYSSGEKKDEVYLNLVLDYVPETVYRVARHYSRAKQTLPVIYVKLYMYQLFRSL 169
           VRL    +S  +KK    L LV ++  + +    +++      L    VK +++QL + L
Sbjct: 64  VRLHDVLHS--DKK----LTLVFEFCDQDL---KKYFDSCNGDLDPEIVKSFLFQLLKGL 114

Query: 170 AYIHSFGICHRDIKPQNLLLDPDTAVLKLCDFGSAKQLVRGEPNVSY---ICSRYYRAPE 226
            + HS  + HRD+KPQNLL++ +   LKL DFG A+    G P   Y   + + +YR P+
Sbjct: 115 GFCHSRNVLHRDLKPQNLLINRN-GELKLADFGLARAF--GIPVRCYSAEVVTLWYRPPD 171

Query: 227 LIFGATDYTSSIDVWSAGCVLAELL-LGQPIFPGDSGVDQLVEIIKVLGTPTREQIREMN 285
           ++FGA  Y++SID+WSAGC+ AEL   G+P+FPG+   DQL  I ++LGTPT EQ   M 
Sbjct: 172 VLFGAKLYSTSIDMWSAGCIFAELANAGRPLFPGNDVDDQLKRIFRLLGTPTEEQWPSMT 231

Query: 286 PNYTEFKFPQIKAHPWTKDSSGTGHFTSGVRVFRPRTPPEAIALCSRLLEYTPTARLTPL 345
                 K P  K +P    +      TS V V  P+       L   LL+  P  R++  
Sbjct: 232 ------KLPDYKPYPMYPAT------TSLVNVV-PKLNATGRDLLQNLLKCNPVQRISAE 278

Query: 346 EACAHSFFDELRDP 359
           EA  H +F +   P
Sbjct: 279 EALQHPYFSDFCPP 292


>gi|20986497 mitogen-activated protein kinase 7 isoform 1 [Homo
           sapiens]
          Length = 816

 Score =  158 bits (399), Expect = 1e-38
 Identities = 99/319 (31%), Positives = 164/319 (51%), Gaps = 33/319 (10%)

Query: 56  YTDTKVIGNGSFGVVYQAKLCDSGELVAIKK------VLQDKRFKNRELQIMRKLDHCNI 109
           Y   + IGNG++GVV  A+   +G+ VAIKK      V+ + +   REL+I++   H NI
Sbjct: 55  YEIIETIGNGAYGVVSSARRRLTGQQVAIKKIPNAFDVVTNAKRTLRELKILKHFKHDNI 114

Query: 110 VRLRYFFYSSGEKKDEVYLNLVLDYVPETVYRVARHYSRAKQTLPVIYVKLYMYQLFRSL 169
           + ++     +    +   + +VLD +   ++++      + Q L + +V+ ++YQL R L
Sbjct: 115 IAIKDILRPTVPYGEFKSVYVVLDLMESDLHQIIH----SSQPLTLEHVRYFLYQLLRGL 170

Query: 170 AYIHSFGICHRDIKPQNLLLDPDTAVLKLCDFGSAKQLVRGEPN-----VSYICSRYYRA 224
            Y+HS  + HRD+KP NLL++ +   LK+ DFG A+ L             Y+ +R+YRA
Sbjct: 171 KYMHSAQVIHRDLKPSNLLVN-ENCELKIGDFGMARGLCTSPAEHQYFMTEYVATRWYRA 229

Query: 225 PELIFGATDYTSSIDVWSAGCVLAELLLGQPIFPGDSGVDQLVEIIKVLGTPTREQIREM 284
           PEL+    +YT +ID+WS GC+  E+L  + +FPG + V QL  I+ VLGTP+   I+ +
Sbjct: 230 PELMLSLHEYTQAIDLWSVGCIFGEMLARRQLFPGKNYVHQLQLIMMVLGTPSPAVIQAV 289

Query: 285 NPNYTEF---KFPQIKAHPWTKDSSGTGHFTSGVRVFRPRTPPEAIALCSRLLEYTPTAR 341
                       P  +  PW                  P    +A++L  R+L + P+AR
Sbjct: 290 GAERVRAYIQSLPPRQPVPW--------------ETVYPGADRQALSLLGRMLRFEPSAR 335

Query: 342 LTPLEACAHSFFDELRDPN 360
           ++   A  H F  +  DP+
Sbjct: 336 ISAAAALRHPFLAKYHDPD 354


>gi|209529736 mitogen-activated protein kinase 7 isoform 1 [Homo
           sapiens]
          Length = 816

 Score =  158 bits (399), Expect = 1e-38
 Identities = 99/319 (31%), Positives = 164/319 (51%), Gaps = 33/319 (10%)

Query: 56  YTDTKVIGNGSFGVVYQAKLCDSGELVAIKK------VLQDKRFKNRELQIMRKLDHCNI 109
           Y   + IGNG++GVV  A+   +G+ VAIKK      V+ + +   REL+I++   H NI
Sbjct: 55  YEIIETIGNGAYGVVSSARRRLTGQQVAIKKIPNAFDVVTNAKRTLRELKILKHFKHDNI 114

Query: 110 VRLRYFFYSSGEKKDEVYLNLVLDYVPETVYRVARHYSRAKQTLPVIYVKLYMYQLFRSL 169
           + ++     +    +   + +VLD +   ++++      + Q L + +V+ ++YQL R L
Sbjct: 115 IAIKDILRPTVPYGEFKSVYVVLDLMESDLHQIIH----SSQPLTLEHVRYFLYQLLRGL 170

Query: 170 AYIHSFGICHRDIKPQNLLLDPDTAVLKLCDFGSAKQLVRGEPN-----VSYICSRYYRA 224
            Y+HS  + HRD+KP NLL++ +   LK+ DFG A+ L             Y+ +R+YRA
Sbjct: 171 KYMHSAQVIHRDLKPSNLLVN-ENCELKIGDFGMARGLCTSPAEHQYFMTEYVATRWYRA 229

Query: 225 PELIFGATDYTSSIDVWSAGCVLAELLLGQPIFPGDSGVDQLVEIIKVLGTPTREQIREM 284
           PEL+    +YT +ID+WS GC+  E+L  + +FPG + V QL  I+ VLGTP+   I+ +
Sbjct: 230 PELMLSLHEYTQAIDLWSVGCIFGEMLARRQLFPGKNYVHQLQLIMMVLGTPSPAVIQAV 289

Query: 285 NPNYTEF---KFPQIKAHPWTKDSSGTGHFTSGVRVFRPRTPPEAIALCSRLLEYTPTAR 341
                       P  +  PW                  P    +A++L  R+L + P+AR
Sbjct: 290 GAERVRAYIQSLPPRQPVPW--------------ETVYPGADRQALSLLGRMLRFEPSAR 335

Query: 342 LTPLEACAHSFFDELRDPN 360
           ++   A  H F  +  DP+
Sbjct: 336 ISAAAALRHPFLAKYHDPD 354


>gi|209529734 mitogen-activated protein kinase 7 isoform 1 [Homo
           sapiens]
          Length = 816

 Score =  158 bits (399), Expect = 1e-38
 Identities = 99/319 (31%), Positives = 164/319 (51%), Gaps = 33/319 (10%)

Query: 56  YTDTKVIGNGSFGVVYQAKLCDSGELVAIKK------VLQDKRFKNRELQIMRKLDHCNI 109
           Y   + IGNG++GVV  A+   +G+ VAIKK      V+ + +   REL+I++   H NI
Sbjct: 55  YEIIETIGNGAYGVVSSARRRLTGQQVAIKKIPNAFDVVTNAKRTLRELKILKHFKHDNI 114

Query: 110 VRLRYFFYSSGEKKDEVYLNLVLDYVPETVYRVARHYSRAKQTLPVIYVKLYMYQLFRSL 169
           + ++     +    +   + +VLD +   ++++      + Q L + +V+ ++YQL R L
Sbjct: 115 IAIKDILRPTVPYGEFKSVYVVLDLMESDLHQIIH----SSQPLTLEHVRYFLYQLLRGL 170

Query: 170 AYIHSFGICHRDIKPQNLLLDPDTAVLKLCDFGSAKQLVRGEPN-----VSYICSRYYRA 224
            Y+HS  + HRD+KP NLL++ +   LK+ DFG A+ L             Y+ +R+YRA
Sbjct: 171 KYMHSAQVIHRDLKPSNLLVN-ENCELKIGDFGMARGLCTSPAEHQYFMTEYVATRWYRA 229

Query: 225 PELIFGATDYTSSIDVWSAGCVLAELLLGQPIFPGDSGVDQLVEIIKVLGTPTREQIREM 284
           PEL+    +YT +ID+WS GC+  E+L  + +FPG + V QL  I+ VLGTP+   I+ +
Sbjct: 230 PELMLSLHEYTQAIDLWSVGCIFGEMLARRQLFPGKNYVHQLQLIMMVLGTPSPAVIQAV 289

Query: 285 NPNYTEF---KFPQIKAHPWTKDSSGTGHFTSGVRVFRPRTPPEAIALCSRLLEYTPTAR 341
                       P  +  PW                  P    +A++L  R+L + P+AR
Sbjct: 290 GAERVRAYIQSLPPRQPVPW--------------ETVYPGADRQALSLLGRMLRFEPSAR 335

Query: 342 LTPLEACAHSFFDELRDPN 360
           ++   A  H F  +  DP+
Sbjct: 336 ISAAAALRHPFLAKYHDPD 354


>gi|20986531 mitogen-activated protein kinase 1 [Homo sapiens]
          Length = 360

 Score =  155 bits (393), Expect = 5e-38
 Identities = 101/318 (31%), Positives = 166/318 (52%), Gaps = 35/318 (11%)

Query: 56  YTDTKVIGNGSFGVVYQAKLCDSGELVAIKKV--LQDKRFKNR---ELQIMRKLDHCNIV 110
           YT+   IG G++G+V  A    +   VAIKK+   + + +  R   E++I+ +  H NI+
Sbjct: 25  YTNLSYIGEGAYGMVCSAYDNVNKVRVAIKKISPFEHQTYCQRTLREIKILLRFRHENII 84

Query: 111 RLRYFFYSSG-EKKDEVYLNLVLDYVPETVYRVARHYSRAKQTLPVIYVKLYMYQLFRSL 169
            +     +   E+  +VY+  V D +   +Y++ +      Q L   ++  ++YQ+ R L
Sbjct: 85  GINDIIRAPTIEQMKDVYI--VQDLMETDLYKLLK-----TQHLSNDHICYFLYQILRGL 137

Query: 170 AYIHSFGICHRDIKPQNLLLDPDTAVLKLCDFGSAKQLVRGEPNVS----YICSRYYRAP 225
            YIHS  + HRD+KP NLLL+  T  LK+CDFG A+       +      Y+ +R+YRAP
Sbjct: 138 KYIHSANVLHRDLKPSNLLLNT-TCDLKICDFGLARVADPDHDHTGFLTEYVATRWYRAP 196

Query: 226 ELIFGATDYTSSIDVWSAGCVLAELLLGQPIFPGDSGVDQLVEIIKVLGTPTREQIR--- 282
           E++  +  YT SID+WS GC+LAE+L  +PIFPG   +DQL  I+ +LG+P++E +    
Sbjct: 197 EIMLNSKGYTKSIDIWSVGCILAEMLSNRPIFPGKHYLDQLNHILGILGSPSQEDLNCII 256

Query: 283 EMNPNYTEFKFPQIKAHPWTKDSSGTGHFTSGVRVFRPRTPPEAIALCSRLLEYTPTARL 342
            +         P     PW              R+F P    +A+ L  ++L + P  R+
Sbjct: 257 NLKARNYLLSLPHKNKVPWN-------------RLF-PNADSKALDLLDKMLTFNPHKRI 302

Query: 343 TPLEACAHSFFDELRDPN 360
              +A AH + ++  DP+
Sbjct: 303 EVEQALAHPYLEQYYDPS 320


>gi|66932916 mitogen-activated protein kinase 1 [Homo sapiens]
          Length = 360

 Score =  155 bits (393), Expect = 5e-38
 Identities = 101/318 (31%), Positives = 166/318 (52%), Gaps = 35/318 (11%)

Query: 56  YTDTKVIGNGSFGVVYQAKLCDSGELVAIKKV--LQDKRFKNR---ELQIMRKLDHCNIV 110
           YT+   IG G++G+V  A    +   VAIKK+   + + +  R   E++I+ +  H NI+
Sbjct: 25  YTNLSYIGEGAYGMVCSAYDNVNKVRVAIKKISPFEHQTYCQRTLREIKILLRFRHENII 84

Query: 111 RLRYFFYSSG-EKKDEVYLNLVLDYVPETVYRVARHYSRAKQTLPVIYVKLYMYQLFRSL 169
            +     +   E+  +VY+  V D +   +Y++ +      Q L   ++  ++YQ+ R L
Sbjct: 85  GINDIIRAPTIEQMKDVYI--VQDLMETDLYKLLK-----TQHLSNDHICYFLYQILRGL 137

Query: 170 AYIHSFGICHRDIKPQNLLLDPDTAVLKLCDFGSAKQLVRGEPNVS----YICSRYYRAP 225
            YIHS  + HRD+KP NLLL+  T  LK+CDFG A+       +      Y+ +R+YRAP
Sbjct: 138 KYIHSANVLHRDLKPSNLLLNT-TCDLKICDFGLARVADPDHDHTGFLTEYVATRWYRAP 196

Query: 226 ELIFGATDYTSSIDVWSAGCVLAELLLGQPIFPGDSGVDQLVEIIKVLGTPTREQIR--- 282
           E++  +  YT SID+WS GC+LAE+L  +PIFPG   +DQL  I+ +LG+P++E +    
Sbjct: 197 EIMLNSKGYTKSIDIWSVGCILAEMLSNRPIFPGKHYLDQLNHILGILGSPSQEDLNCII 256

Query: 283 EMNPNYTEFKFPQIKAHPWTKDSSGTGHFTSGVRVFRPRTPPEAIALCSRLLEYTPTARL 342
            +         P     PW              R+F P    +A+ L  ++L + P  R+
Sbjct: 257 NLKARNYLLSLPHKNKVPWN-------------RLF-PNADSKALDLLDKMLTFNPHKRI 302

Query: 343 TPLEACAHSFFDELRDPN 360
              +A AH + ++  DP+
Sbjct: 303 EVEQALAHPYLEQYYDPS 320


>gi|20128774 mitogen-activated protein kinase 11 [Homo sapiens]
          Length = 364

 Score =  155 bits (392), Expect = 7e-38
 Identities = 100/304 (32%), Positives = 160/304 (52%), Gaps = 25/304 (8%)

Query: 62  IGNGSFGVVYQAKLCDSGELVAIKKV------LQDKRFKNRELQIMRKLDHCNIVRLRYF 115
           +G+G++G V  A      + VA+KK+      L   R   REL++++ L H N++ L   
Sbjct: 30  VGSGAYGSVCSAYDARLRQKVAVKKLSRPFQSLIHARRTYRELRLLKHLKHENVIGLLDV 89

Query: 116 FYSSGEKKDEVYLNLVLDYVPETVYRVARHYSRAKQTLPVIYVKLYMYQLFRSLAYIHSF 175
           F  +   +D   + LV   +   +  + +      Q L   +V+  +YQL R L YIHS 
Sbjct: 90  FTPATSIEDFSEVYLVTTLMGADLNNIVKC-----QALSDEHVQFLVYQLLRGLKYIHSA 144

Query: 176 GICHRDIKPQNLLLDPDTAVLKLCDFGSAKQLVRGEPNVSYICSRYYRAPELIFGATDYT 235
           GI HRD+KP N+ ++ D   L++ DFG A+Q    E    Y+ +R+YRAPE++     Y 
Sbjct: 145 GIIHRDLKPSNVAVNEDCE-LRILDFGLARQA--DEEMTGYVATRWYRAPEIMLNWMHYN 201

Query: 236 SSIDVWSAGCVLAELLLGQPIFPGDSGVDQLVEIIKVLGTPTREQIREMNPNYTEFKFPQ 295
            ++D+WS GC++AELL G+ +FPG   +DQL  I++V+GTP+ E + +++  +       
Sbjct: 202 QTVDIWSVGCIMAELLQGKALFPGSDYIDQLKRIMEVVGTPSPEVLAKISSEHARTYIQS 261

Query: 296 IKAHPWTKDSSGTGHFTSGVRVFRPRTPPEAIALCSRLLEYTPTARLTPLEACAHSFFDE 355
           +   P  KD S          +FR    P AI L  R+L      R++  EA AH++F +
Sbjct: 262 LPPMP-QKDLSS---------IFRGAN-PLAIDLLGRMLVLDSDQRVSAAEALAHAYFSQ 310

Query: 356 LRDP 359
             DP
Sbjct: 311 YHDP 314


>gi|197333744 PCTAIRE protein kinase 1 isoform 2 [Homo sapiens]
          Length = 502

 Score =  154 bits (388), Expect = 2e-37
 Identities = 102/352 (28%), Positives = 176/352 (50%), Gaps = 39/352 (11%)

Query: 55  SYTDTKVIGNGSFGVVYQAKLCDSGELVAIKKVLQDKR-----FKNRELQIMRKLDHCNI 109
           +Y     +G G++  VY+ K   +  LVA+K++  +          RE+ +++ L H NI
Sbjct: 170 TYIKLDKLGEGTYATVYKGKSKLTDNLVALKEIRLEHEEGAPCTAIREVSLLKDLKHANI 229

Query: 110 VRLRYFFYSSGEKKDEVYLNLVLDYVPETVYRVARHYSRAKQTLPVIYVKLYMYQLFRSL 169
           V L    ++      E  L LV +Y+ + +    ++       + +  VKL+++QL R L
Sbjct: 230 VTLHDIIHT------EKSLTLVFEYLDKDL---KQYLDDCGNIINMHNVKLFLFQLLRGL 280

Query: 170 AYIHSFGICHRDIKPQNLLLDPDTAVLKLCDFGSAKQLVRGEPNVSY---ICSRYYRAPE 226
           AY H   + HRD+KPQNLL++ +   LKL DFG A+   +  P  +Y   + + +YR P+
Sbjct: 281 AYCHRQKVLHRDLKPQNLLIN-ERGELKLADFGLAR--AKSIPTKTYSNEVVTLWYRPPD 337

Query: 227 LIFGATDYTSSIDVWSAGCVLAELLLGQPIFPGDSGVDQLVEIIKVLGTPTREQIREM-- 284
           ++ G+TDY++ ID+W  GC+  E+  G+P+FPG +  +QL  I ++LGTPT E    +  
Sbjct: 338 ILLGSTDYSTQIDMWGVGCIFYEMATGRPLFPGSTVEEQLHFIFRILGTPTEETWPGILS 397

Query: 285 NPNYTEFKFPQIKAHPWTKDSSGTGHFTSGVRVFRPRTPPEAIALCSRLLEYTPTARLTP 344
           N  +  + +P+ +A      +              PR   +   L ++LL++    R++ 
Sbjct: 398 NEEFKTYNYPKYRAEALLSHA--------------PRLDSDGADLLTKLLQFEGRNRISA 443

Query: 345 LEACAHSFFDELRDPNVKLPNGRDTPALFNFTTQELSSNPPLATILIPPHAR 396
            +A  H FF  L +   KLP   DT ++F     +L     L +  +P   R
Sbjct: 444 EDAMKHPFFLSLGERIHKLP---DTTSIFALKEIQLQKEASLRSSSMPDSGR 492


>gi|5453860 PCTAIRE protein kinase 1 isoform 1 [Homo sapiens]
          Length = 496

 Score =  154 bits (388), Expect = 2e-37
 Identities = 102/352 (28%), Positives = 176/352 (50%), Gaps = 39/352 (11%)

Query: 55  SYTDTKVIGNGSFGVVYQAKLCDSGELVAIKKVLQDKR-----FKNRELQIMRKLDHCNI 109
           +Y     +G G++  VY+ K   +  LVA+K++  +          RE+ +++ L H NI
Sbjct: 164 TYIKLDKLGEGTYATVYKGKSKLTDNLVALKEIRLEHEEGAPCTAIREVSLLKDLKHANI 223

Query: 110 VRLRYFFYSSGEKKDEVYLNLVLDYVPETVYRVARHYSRAKQTLPVIYVKLYMYQLFRSL 169
           V L    ++      E  L LV +Y+ + +    ++       + +  VKL+++QL R L
Sbjct: 224 VTLHDIIHT------EKSLTLVFEYLDKDL---KQYLDDCGNIINMHNVKLFLFQLLRGL 274

Query: 170 AYIHSFGICHRDIKPQNLLLDPDTAVLKLCDFGSAKQLVRGEPNVSY---ICSRYYRAPE 226
           AY H   + HRD+KPQNLL++ +   LKL DFG A+   +  P  +Y   + + +YR P+
Sbjct: 275 AYCHRQKVLHRDLKPQNLLIN-ERGELKLADFGLAR--AKSIPTKTYSNEVVTLWYRPPD 331

Query: 227 LIFGATDYTSSIDVWSAGCVLAELLLGQPIFPGDSGVDQLVEIIKVLGTPTREQIREM-- 284
           ++ G+TDY++ ID+W  GC+  E+  G+P+FPG +  +QL  I ++LGTPT E    +  
Sbjct: 332 ILLGSTDYSTQIDMWGVGCIFYEMATGRPLFPGSTVEEQLHFIFRILGTPTEETWPGILS 391

Query: 285 NPNYTEFKFPQIKAHPWTKDSSGTGHFTSGVRVFRPRTPPEAIALCSRLLEYTPTARLTP 344
           N  +  + +P+ +A      +              PR   +   L ++LL++    R++ 
Sbjct: 392 NEEFKTYNYPKYRAEALLSHA--------------PRLDSDGADLLTKLLQFEGRNRISA 437

Query: 345 LEACAHSFFDELRDPNVKLPNGRDTPALFNFTTQELSSNPPLATILIPPHAR 396
            +A  H FF  L +   KLP   DT ++F     +L     L +  +P   R
Sbjct: 438 EDAMKHPFFLSLGERIHKLP---DTTSIFALKEIQLQKEASLRSSSMPDSGR 486


>gi|89903018 cell cycle related kinase isoform 3 [Homo sapiens]
          Length = 346

 Score =  153 bits (386), Expect = 3e-37
 Identities = 97/304 (31%), Positives = 160/304 (52%), Gaps = 37/304 (12%)

Query: 62  IGNGSFGVVYQAKLCDSGELVAIKKV----LQDKRFKNRELQIMRKL----DHCNIVRLR 113
           IG G+ G+V++AK  ++GE+VA+KKV    L+D  F N+ L+ ++ L    D+  +V+L+
Sbjct: 10  IGEGAHGIVFKAKHVETGEIVALKKVALRRLEDG-FPNQALREIKALQEMEDNQYVVQLK 68

Query: 114 YFFYSSGEKKDEVYLNLVLDYVPETVYRVARHYSRAKQTLPVIYVKLYMYQLFRSLAYIH 173
             F   G         L  +++   +  V RH   A++ L    VK Y+  L + +A+ H
Sbjct: 69  AVFPHGGG------FVLAFEFMLSDLAEVVRH---AQRPLAQAQVKSYLQMLLKGVAFCH 119

Query: 174 SFGICHRDIKPQNLLLDPDTAVLKLCDFGSAKQLVRGEPNV--SYICSRYYRAPELIFGA 231
           +  I HRD+KP NLL+   +  LK+ DFG A+        +    + +R+YRAPEL++GA
Sbjct: 120 ANNIVHRDLKPANLLISA-SGQLKIADFGLARVFSPDGSRLYTHQVATRWYRAPELLYGA 178

Query: 232 TDYTSSIDVWSAGCVLAELLLGQPIFPGDSGVDQLVEIIKVLGTPTREQIREMN--PNYT 289
             Y   +D+WS GC++ ELL G P+FPG + ++QL  ++++LGTP  +   E+   P+Y 
Sbjct: 179 RQYDQGVDLWSVGCIMGELLNGSPLFPGKNDIEQLCYVLRILGTPNPQVWPELTELPDYN 238

Query: 290 EFKFPQIKAHPWTKDSSGTGHFTSGVRVFRPRTPPEAIALCSRLLEYTPTARLTPLEACA 349
           +  F +    P              +    P   P+A+ L  + L Y P  R+   +A  
Sbjct: 239 KISFKEQVPMP--------------LEEVLPDVSPQALDLLGQFLLYPPHQRIAASKALL 284

Query: 350 HSFF 353
           H +F
Sbjct: 285 HQYF 288


>gi|95147356 mitogen-activated protein kinase 15 [Homo sapiens]
          Length = 544

 Score =  152 bits (385), Expect = 4e-37
 Identities = 100/319 (31%), Positives = 165/319 (51%), Gaps = 34/319 (10%)

Query: 56  YTDTKVIGNGSFGVVYQAKLCDSGELVAIKKVLQDKRFKN------RELQIMRKL-DHCN 108
           Y   + +G G++G+V++A    +GE+VAIKK+    R K       RE+ ++++  DH N
Sbjct: 13  YLLRRQLGQGAYGIVWKAVDRRTGEVVAIKKIFDAFRDKTDAQRTFREITLLQEFGDHPN 72

Query: 109 IVRLRYFFYSSGEKKDEVYLNLVLDYVPETVYRVARHYSRAKQTLPVIYVKLYMYQLFRS 168
           I+ L     +  ++  ++YL  V +++   +  V R        L  ++V+   YQL R+
Sbjct: 73  IISLLDVIRAENDR--DIYL--VFEFMDTDLNAVIRKGG----LLQDVHVRSIFYQLLRA 124

Query: 169 LAYIHSFGICHRDIKPQNLLLDPDTAVLKLCDFGSAKQL------VRGEPNVSYICSRYY 222
             ++HS  + HRD KP N+LLD +  V KLCDFG A+ L         +    Y+ +R+Y
Sbjct: 125 TRFLHSGHVVHRDQKPSNVLLDANCTV-KLCDFGLARSLGDLPEGPEDQAVTEYVATRWY 183

Query: 223 RAPELIFGATDYTSSIDVWSAGCVLAELLLGQPIFPGDSGVDQLVEIIKVLGTPTREQIR 282
           RAPE++  +  YT  +D+WS GC+L E+L G+P+FPG S + QL  I++ +  P+ E + 
Sbjct: 184 RAPEVLLSSHRYTLGVDMWSLGCILGEMLRGRPLFPGTSTLHQLELILETIPPPSEEDLL 243

Query: 283 EMNPNYTEFKFPQIKAHP-WTKDSSGTGHFTSGVRVFRPRTPPEAIALCSRLLEYTPTAR 341
            +          Q+ + P  T D+           +  P T PEA+ L  RLL + P  R
Sbjct: 244 ALGSGCRASVLHQLGSRPRQTLDA-----------LLPPDTSPEALDLLRRLLVFAPDKR 292

Query: 342 LTPLEACAHSFFDELRDPN 360
           L+  +A  H +      P+
Sbjct: 293 LSATQALQHPYVQRFHCPS 311


>gi|48255970 mitogen-activated protein kinase 12 [Homo sapiens]
          Length = 367

 Score =  152 bits (383), Expect = 7e-37
 Identities = 96/309 (31%), Positives = 159/309 (51%), Gaps = 25/309 (8%)

Query: 56  YTDTKVIGNGSFGVVYQAKLCDSGELVAIKKV---LQDKRFKNR---ELQIMRKLDHCNI 109
           Y D + +G+G++G V  A    +G  VAIKK+    Q + F  R   EL++++ + H N+
Sbjct: 27  YRDLQPVGSGAYGAVCSAVDGRTGAKVAIKKLYRPFQSELFAKRAYRELRLLKHMRHENV 86

Query: 110 VRLRYFFYSSGEKKDEVYLNLVLDYVPETVYRVARHYSRAKQTLPVIYVKLYMYQLFRSL 169
           + L   F       D     LV+ ++   + ++ +H    +       ++  +YQ+ + L
Sbjct: 87  IGLLDVFTPDETLDDFTDFYLVMPFMGTDLGKLMKHEKLGEDR-----IQFLVYQMLKGL 141

Query: 170 AYIHSFGICHRDIKPQNLLLDPDTAVLKLCDFGSAKQLVRGEPNVSYICSRYYRAPELIF 229
            YIH+ GI HRD+KP NL ++ D   LK+ DFG A+Q         Y+ +R+YRAPE+I 
Sbjct: 142 RYIHAAGIIHRDLKPGNLAVNEDCE-LKILDFGLARQA--DSEMTGYVVTRWYRAPEVIL 198

Query: 230 GATDYTSSIDVWSAGCVLAELLLGQPIFPGDSGVDQLVEIIKVLGTPTREQIREMNPNYT 289
               YT ++D+WS GC++AE++ G+ +F G   +DQL EI+KV GTP  E ++ +  +  
Sbjct: 199 NWMRYTQTVDIWSVGCIMAEMITGKTLFKGSDHLDQLKEIMKVTGTPPAEFVQRLQSDEA 258

Query: 290 EFKFPQIKAHPWTKDSSGTGHFTSGVRVFRPRTPPEAIALCSRLLEYTPTARLTPLEACA 349
           +     +K  P  +        T+          P A+ L  ++L      R+T  EA A
Sbjct: 259 K---NYMKGLPELEKKDFASILTN--------ASPLAVNLLEKMLVLDAEQRVTAGEALA 307

Query: 350 HSFFDELRD 358
           H +F+ L D
Sbjct: 308 HPYFESLHD 316


>gi|21040235 PFTAIRE protein kinase 2 [Homo sapiens]
          Length = 384

 Score =  152 bits (383), Expect = 7e-37
 Identities = 108/350 (30%), Positives = 172/350 (49%), Gaps = 46/350 (13%)

Query: 55  SYTDTKVIGNGSFGVVYQAKLCDSGELVAIKKVLQDKR-----FKNRELQIMRKLDHCNI 109
           SY + + +G GS+  VY+     +G+LVA+K +  +          RE  +++ L H NI
Sbjct: 51  SYLNLEKLGEGSYATVYKGISRINGQLVALKVISMNAEEGVPFTAIREASLLKGLKHANI 110

Query: 110 VRLRYFFYSSGEKKDEVYLNLVLDYVPETVYR-VARHYSRAKQTLPVIYVKLYMYQLFRS 168
           V L           D ++    L +V E ++  +A++ S+    L    V+L+M+QL R 
Sbjct: 111 VLLH----------DIIHTKETLTFVFEYMHTDLAQYMSQHPGGLHPHNVRLFMFQLLRG 160

Query: 169 LAYIHSFGICHRDIKPQNLLLDPDTAVLKLCDFGSAK-QLVRGEPNVSYICSRYYRAPEL 227
           LAYIH   + HRD+KPQNLL+      LKL DFG A+ + +  +   S + + +YR P+ 
Sbjct: 161 LAYIHHQHVLHRDLKPQNLLIS-HLGELKLADFGLARAKSIPSQTYSSEVVTLWYRPPDA 219

Query: 228 IFGATDYTSSIDVWSAGCVLAELLLGQPIFPGDSGV-DQLVEIIKVLGTPTRE------Q 280
           + GAT+Y+S +D+W AGC+  E+  GQP+FPG S + +QL +I +VLG PT +      +
Sbjct: 220 LLGATEYSSELDIWGAGCIFIEMFQGQPLFPGVSNILEQLEKIWEVLGVPTEDTWPGVSK 279

Query: 281 IREMNPNYTEFKFPQIKAHPWTKDSSGTGHFTSGVRVFRPRTPPEAIALCSRLLEYTPTA 340
           +   NP +     P+     W                 R    PEA  L S++L+  P  
Sbjct: 280 LPNYNPEWFPLPTPRSLHVVWN----------------RLGRVPEAEDLASQMLKGFPRD 323

Query: 341 RLTPLEACAHSFFDELRDPNVKLPNGRDTPALFNFTTQELSSNPPLATIL 390
           R++  EA  H +F  L     +LP+         FT   +   P +  +L
Sbjct: 324 RVSAQEALVHDYFSALPSQLYQLPDEESL-----FTVSGVRLKPEMCDLL 368


  Database: hs.faa
    Posted date:  Aug 4, 2009  4:42 PM
  Number of letters in database: 18,247,518
  Number of sequences in database:  37,866
  
Lambda     K      H
   0.318    0.134    0.399 

Gapped
Lambda     K      H
   0.267   0.0410    0.140 


Matrix: BLOSUM62
Gap Penalties: Existence: 11, Extension: 1
Number of Hits to DB: 17,699,460
Number of Sequences: 37866
Number of extensions: 843298
Number of successful extensions: 4328
Number of sequences better than 10.0: 30
Number of HSP's better than 10.0 without gapping: 521
Number of HSP's successfully gapped in prelim test: 241
Number of HSP's that attempted gapping in prelim test: 2237
Number of HSP's gapped (non-prelim): 985
length of query: 433
length of database: 18,247,518
effective HSP length: 105
effective length of query: 328
effective length of database: 14,271,588
effective search space: 4681080864
effective search space used: 4681080864
T: 11
A: 40
X1: 16 ( 7.3 bits)
X2: 38 (14.6 bits)
X3: 64 (24.7 bits)
S1: 41 (21.7 bits)
S2: 63 (28.9 bits)
Search results were obtained with NCBI BLAST and RefSeq entries.