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Search of human proteins with 21361272
BLASTP 2.2.11 [Jun-05-2005]
Reference: Altschul, Stephen F., Thomas L. Madden, Alejandro A. Schaffer,
Jinghui Zhang, Zheng Zhang, Webb Miller, and David J. Lipman (1997),
"Gapped BLAST and PSI-BLAST: a new generation of protein database search
programs", Nucleic Acids Res. 25:3389-3402.
Query= gi|21361272 myeloid/lymphoid or mixed-lineage leukemia
(trithorax homolog, Drosophila); translocated to, 1 [Homo sapiens]
(559 letters)
Database: hs.faa
37,866 sequences; 18,247,518 total letters
Searching..................................................done
Score E
Sequences producing significant alignments: (bits) Value
gi|21361272 myeloid/lymphoid or mixed-lineage leukemia (trithora... 1128 0.0
gi|156104889 myeloid/lymphoid or mixed-lineage leukemia (trithor... 540 e-153
gi|89001107 dentin sialophosphoprotein preproprotein [Homo sapiens] 99 1e-20
gi|169658378 trinucleotide repeat containing 18 [Homo sapiens] 86 9e-17
gi|148596949 nucleolar and coiled-body phosphoprotein 1 [Homo sa... 84 3e-16
gi|32483416 neurofilament, heavy polypeptide 200kDa [Homo sapiens] 74 3e-13
gi|50962882 G patch domain containing 8 [Homo sapiens] 74 3e-13
gi|16332372 cell division cycle 2-like 1 (PITSLRE proteins) isof... 72 1e-12
gi|16332362 cell division cycle 2-like 1 (PITSLRE proteins) isof... 72 1e-12
gi|42542379 serine/arginine repetitive matrix 1 [Homo sapiens] 72 1e-12
gi|16332364 cell division cycle 2-like 1 (PITSLRE proteins) isof... 72 2e-12
gi|16332358 cell division cycle 2-like 1 (PITSLRE proteins) isof... 72 2e-12
gi|117935038 cylicin, basic protein of sperm head cytoskeleton 1... 71 2e-12
gi|19718731 bromodomain-containing protein 4 isoform long [Homo ... 70 5e-12
gi|148763345 cell division cycle 2-like 2 isoform 4 [Homo sapiens] 68 2e-11
gi|33620755 YEATS domain containing 2 [Homo sapiens] 68 2e-11
gi|132626688 mediator of DNA-damage checkpoint 1 [Homo sapiens] 67 3e-11
gi|21361282 splicing factor, arginine/serine-rich 4 [Homo sapiens] 66 7e-11
gi|5174573 myeloid/lymphoid or mixed-lineage leukemia trithorax ... 66 7e-11
gi|118572613 splicing coactivator subunit SRm300 [Homo sapiens] 66 7e-11
gi|31377595 zinc finger CCCH-type containing 18 [Homo sapiens] 66 1e-10
gi|148763347 cell division cycle 2-like 2 isoform 1 [Homo sapiens] 65 2e-10
gi|169218320 PREDICTED: similar to BCL2-associated transcription... 65 2e-10
gi|7661950 SH2 domain binding protein 1 [Homo sapiens] 65 2e-10
gi|48255931 hepatoma-derived growth factor-related protein 2 iso... 65 2e-10
gi|14249158 hepatoma-derived growth factor-related protein 2 iso... 65 2e-10
gi|117938251 BCL2-associated transcription factor 1 isoform 2 [H... 65 2e-10
gi|16332370 cell division cycle 2-like 1 (PITSLRE proteins) isof... 64 4e-10
gi|224548936 hypothetical protein LOC100170229 [Homo sapiens] 63 8e-10
gi|226509740 SR-related CTD-associated factor 1 [Homo sapiens] 62 1e-09
>gi|21361272 myeloid/lymphoid or mixed-lineage leukemia (trithorax
homolog, Drosophila); translocated to, 1 [Homo sapiens]
Length = 559
Score = 1128 bits (2918), Expect = 0.0
Identities = 559/559 (100%), Positives = 559/559 (100%)
Query: 1 MDNQCTVQVRLELGHRAQLRKKPTTEGFTHDWMVFVRGPEQCDIQHFVEKVVFWLHDSFP 60
MDNQCTVQVRLELGHRAQLRKKPTTEGFTHDWMVFVRGPEQCDIQHFVEKVVFWLHDSFP
Sbjct: 1 MDNQCTVQVRLELGHRAQLRKKPTTEGFTHDWMVFVRGPEQCDIQHFVEKVVFWLHDSFP 60
Query: 61 KPRRVCKEPPYKVEESGYAGFIMPIEVHFKNKEEPRKVCFTYDLFLNLEGNPPVNHLRCE 120
KPRRVCKEPPYKVEESGYAGFIMPIEVHFKNKEEPRKVCFTYDLFLNLEGNPPVNHLRCE
Sbjct: 61 KPRRVCKEPPYKVEESGYAGFIMPIEVHFKNKEEPRKVCFTYDLFLNLEGNPPVNHLRCE 120
Query: 121 KLTFNNPTTEFRYKLLRAGGVMVMPEGADTVSRPSPDYPMLPTIPLSAFSDPKKTKPSHG 180
KLTFNNPTTEFRYKLLRAGGVMVMPEGADTVSRPSPDYPMLPTIPLSAFSDPKKTKPSHG
Sbjct: 121 KLTFNNPTTEFRYKLLRAGGVMVMPEGADTVSRPSPDYPMLPTIPLSAFSDPKKTKPSHG 180
Query: 181 SKDANKESSKTSKPHKVTKEHRERPRKDSESKSSSKELEREQAKSSKDTSRKLGEGRLPK 240
SKDANKESSKTSKPHKVTKEHRERPRKDSESKSSSKELEREQAKSSKDTSRKLGEGRLPK
Sbjct: 181 SKDANKESSKTSKPHKVTKEHRERPRKDSESKSSSKELEREQAKSSKDTSRKLGEGRLPK 240
Query: 241 EEKAPPPKAAFKEPKMALKETKLESTSPKGGPPPPPPPPPRASSKRPATADSPKPSAKKQ 300
EEKAPPPKAAFKEPKMALKETKLESTSPKGGPPPPPPPPPRASSKRPATADSPKPSAKKQ
Sbjct: 241 EEKAPPPKAAFKEPKMALKETKLESTSPKGGPPPPPPPPPRASSKRPATADSPKPSAKKQ 300
Query: 301 KKSSSKGSRSAPGTSPRTSSSSSFSDKKPAKDKSSTRGEKVKAESEPREAKKALEVEESN 360
KKSSSKGSRSAPGTSPRTSSSSSFSDKKPAKDKSSTRGEKVKAESEPREAKKALEVEESN
Sbjct: 301 KKSSSKGSRSAPGTSPRTSSSSSFSDKKPAKDKSSTRGEKVKAESEPREAKKALEVEESN 360
Query: 361 SEDEASFKSESAQSSPSNSSSSSDSSSDSDFEPSQNHSQGPLRSMVEDLQSEESDEDDSS 420
SEDEASFKSESAQSSPSNSSSSSDSSSDSDFEPSQNHSQGPLRSMVEDLQSEESDEDDSS
Sbjct: 361 SEDEASFKSESAQSSPSNSSSSSDSSSDSDFEPSQNHSQGPLRSMVEDLQSEESDEDDSS 420
Query: 421 SGEEAAGKTNPGRDSRLSFSDSESDNSADSSLPSREPPPPQKPPPPNSKVSGRRSPESCS 480
SGEEAAGKTNPGRDSRLSFSDSESDNSADSSLPSREPPPPQKPPPPNSKVSGRRSPESCS
Sbjct: 421 SGEEAAGKTNPGRDSRLSFSDSESDNSADSSLPSREPPPPQKPPPPNSKVSGRRSPESCS 480
Query: 481 KPEKILKKGTYDKAYTDELVELHRRLMALRERNVLQQIVNLIEETGHFNVTNTTFDFDLF 540
KPEKILKKGTYDKAYTDELVELHRRLMALRERNVLQQIVNLIEETGHFNVTNTTFDFDLF
Sbjct: 481 KPEKILKKGTYDKAYTDELVELHRRLMALRERNVLQQIVNLIEETGHFNVTNTTFDFDLF 540
Query: 541 SLDETTVRKLQSCLEAVAT 559
SLDETTVRKLQSCLEAVAT
Sbjct: 541 SLDETTVRKLQSCLEAVAT 559
>gi|156104889 myeloid/lymphoid or mixed-lineage leukemia (trithorax
homolog, Drosophila); translocated to, 3 [Homo sapiens]
Length = 568
Score = 540 bits (1391), Expect = e-153
Identities = 315/580 (54%), Positives = 385/580 (66%), Gaps = 34/580 (5%)
Query: 1 MDNQCTVQVRLELGHRAQLRKKPTTEGFTHDWMVFVRGPEQCDIQHFVEKVVFWLHDSFP 60
M + C VQV+LELGHRAQ+RKKPT EGFTHDWMVFVRGPE +IQHFVEKVVF LH+SFP
Sbjct: 1 MASSCAVQVKLELGHRAQVRKKPTVEGFTHDWMVFVRGPEHSNIQHFVEKVVFHLHESFP 60
Query: 61 KPRRVCKEPPYKVEESGYAGFIMPIEVHFKNKEEPRKVCFTYDLFLNLEGNPPVNHLRCE 120
+P+RVCK+PPYKVEESGYAGFI+PIEV+FKNKEEPRKV F YDLFL+LEG+PPVNHLRCE
Sbjct: 61 RPKRVCKDPPYKVEESGYAGFILPIEVYFKNKEEPRKVRFDYDLFLHLEGHPPVNHLRCE 120
Query: 121 KLTFNNPTTEFRYKLLRAGGVMVMPEGADTVSRPSPDYPMLPTIPLSAFSDPKKTKPSHG 180
KLTFNNPT +FR KLL+AGG + S S + S+ S + S
Sbjct: 121 KLTFNNPTEDFRRKLLKAGGDPNRSIHTSSSSSSSSSSSSSSSSSSSSSSSSSSSSSSSS 180
Query: 181 SKDANKESSKT--SKPHKVTKEHRERPRKDS-ESKSSSKELEREQAKSSKDTSRKLGEGR 237
S ++ SS T SKPHK+ KEH+E+P KDS E KS+ KE R+ KSSK++S+K E +
Sbjct: 181 SSSSSSSSSSTSFSKPHKLMKEHKEKPSKDSREHKSAFKEPSRDHNKSSKESSKKPKENK 240
Query: 238 LPKEEKAPPPKAAFKEPKMALKETKLES---TSPKGGPPPPPPPPPRASSKRPATADSPK 294
KEEK PK AFKEPK KE K +S T G +A SKRP +DS +
Sbjct: 241 PLKEEKI-VPKMAFKEPKPMSKEPKPDSNLLTITSG-------QDKKAPSKRPPISDSEE 292
Query: 295 PSAKKQKKSSSKGSRSAPGTSPRTSSSSSFSDKKPAKDKSSTRGEKVKAESEPREAKKA- 353
SAKK+KKSSS+ + ++P + S +DKK KDKS + KVK ESE E KK+
Sbjct: 293 LSAKKRKKSSSEALFKSFSSAPPLILTCS-ADKKQIKDKSHVKMGKVKIESETSEKKKST 351
Query: 354 -------LEVEESNSEDEASFKSESAQSSPSNSSSSSDSSSDSDFEPSQNHSQGPLRSMV 406
++ +S+ E+ S KS+S Q SP++SSSSS SS F PSQ QGPLRS++
Sbjct: 352 LPPFDDIVDPNDSDVEENISSKSDSEQPSPASSSSSSSSS----FTPSQTRQQGPLRSIM 407
Query: 407 EDLQS----EESDE-DDSSSGEEAAGKTNPG--RDSRLSFSDSESDNSADSSLPSREPPP 459
+DL S EESDE +D+ + E N G R R+S SD S+ +S P PP
Sbjct: 408 KDLHSDDNEEESDEVEDNDNDSEMERPVNRGGSRSRRVSLSDGSDSESSSASSPLHHEPP 467
Query: 460 PQKPPPPNSKVSGRRSPESCSKPEKILKKGTYDKAYTDELVELHRRLMALRERNVLQQIV 519
P N+++ +SP SK +K +K G DKAY DELVELHRRLM LRER++LQQIV
Sbjct: 468 PPLLKTNNNQILEVKSPIKQSKSDKQIKNGECDKAYLDELVELHRRLMTLRERHILQQIV 527
Query: 520 NLIEETGHFNVTNTTFDFDLFSLDETTVRKLQSCLEAVAT 559
NLIEETGHF++TNTTFDFDL SLD+TTVRKLQS LE T
Sbjct: 528 NLIEETGHFHITNTTFDFDLCSLDKTTVRKLQSYLETSGT 567
>gi|89001107 dentin sialophosphoprotein preproprotein [Homo sapiens]
Length = 1301
Score = 99.0 bits (245), Expect = 1e-20
Identities = 86/314 (27%), Positives = 124/314 (39%), Gaps = 17/314 (5%)
Query: 171 DPKKTKPSHGSKDANKESSKTSKPHKVTKEHRERPRKDSESKSSSKELEREQAKSSKDT- 229
DP + S+G+ DAN ES S + + KD+ + S SK E + + S+ DT
Sbjct: 464 DPNSSDESNGNDDANSESDNNSSS-RGDASYNSDESKDNGNGSDSKGAEDDDSDSTSDTN 522
Query: 230 -SRKLGEGRLPKEEKAPPPKAAFKEPKMALKETKLESTSPKGGPPPPPPPPPRASSKRPA 288
S G G ++ K + ++S S +
Sbjct: 523 NSDSNGNGNNGNDDNDKSDSGKGKSDSSDSDSSDSSNSSDSSDSSD--------SDSSDS 574
Query: 289 TADSPKPSAKKQKKSSSKGSRSAPGTSPRTSSSSSFSDKKPAKDKSSTRGEKVKAESEPR 348
+ S S+ SS S S +S SS SD + D S ++ + K+ES+
Sbjct: 575 NSSSDSDSSDSDSSDSSDSDSSDSSNSSDSSDSSDSSDSSDSSDSSDSKSDSSKSESDSS 634
Query: 349 EAKKALEVEESNSEDEASFKSESAQSSPSNSSSSSDSSSDSDFEPSQNHSQGPLRSMVED 408
++ + +SNS D + S S+ SNSS SSDSS SD S + S S D
Sbjct: 635 DSDSKSDSSDSNSSDSSDNSDSSDSSNSSNSSDSSDSSDSSDSSSSSDSSNSSDSSDSSD 694
Query: 409 L--QSEESDEDDSSSGEEAAGKTNPGRDSRLSFSDSESDNSADSSLPSREPPPPQKPPPP 466
SE SD DSS + + + +S SDS+S NS+DSS S
Sbjct: 695 SSNSSESSDSSDSSDSDSSDSSDSSNSNS----SDSDSSNSSDSSDSSNSSDSSDSSDSS 750
Query: 467 NSKVSGRRSPESCS 480
NS S S S S
Sbjct: 751 NSSDSSDSSDSSNS 764
Score = 82.8 bits (203), Expect = 8e-16
Identities = 72/312 (23%), Positives = 114/312 (36%), Gaps = 2/312 (0%)
Query: 170 SDPKKTKPSHGSKDANKESSKTSKPHKVTKEHRERPRKDSESKSSSKELEREQAKSSKDT 229
SD + S S D++ S +S + + DS+S SS + + S D+
Sbjct: 555 SDSSNSSDSSDSSDSDSSDSNSSSDSD-SSDSDSSDSSDSDSSDSSNSSDSSDSSDSSDS 613
Query: 230 SRKLGEGRLPKEEKAPPPKAAFKEPKMALKETKLESTSPKGGPPPPPPPPPRA-SSKRPA 288
S + ++ + K ++ +S + SS
Sbjct: 614 SDSSDSSDSKSDSSKSESDSSDSDSKSDSSDSNSSDSSDNSDSSDSSNSSNSSDSSDSSD 673
Query: 289 TADSPKPSAKKQKKSSSKGSRSAPGTSPRTSSSSSFSDKKPAKDKSSTRGEKVKAESEPR 348
++DS S SS S S+ + SS SS SD + D S++ + +
Sbjct: 674 SSDSSSSSDSSNSSDSSDSSDSSNSSESSDSSDSSDSDSSDSSDSSNSNSSDSDSSNSSD 733
Query: 349 EAKKALEVEESNSEDEASFKSESAQSSPSNSSSSSDSSSDSDFEPSQNHSQGPLRSMVED 408
+ + + S+S D ++ S S SNSS SSDSS SD S N S S D
Sbjct: 734 SSDSSNSSDSSDSSDSSNSSDSSDSSDSSNSSDSSDSSDSSDSSDSSNSSDSNDSSNSSD 793
Query: 409 LQSEESDEDDSSSGEEAAGKTNPGRDSRLSFSDSESDNSADSSLPSREPPPPQKPPPPNS 468
+ D S+S + + + DS S S S +S+DSS S +S
Sbjct: 794 SSDSSNSSDSSNSSDSSDSSDSSDSDSSNSSDSSNSSDSSDSSNSSDSSDSSDSSDGSDS 853
Query: 469 KVSGRRSPESCS 480
S R + S
Sbjct: 854 DSSNRSDSSNSS 865
Score = 78.6 bits (192), Expect = 1e-14
Identities = 77/318 (24%), Positives = 114/318 (35%), Gaps = 8/318 (2%)
Query: 170 SDPKKTKPSHGSKDANKESSKTSKPHKVTKEHRERPRKDSESKSSSKELEREQAKSSKDT 229
SD + S S D++ S S + S S SS + S D+
Sbjct: 690 SDSSDSSNSSESSDSSDSSDSDSSDSSDSSNSNSSDSDSSNSSDSSDSSNSSDSSDSSDS 749
Query: 230 SRKLGEGRLPKEEKAPPPKAAFKEPKMALKETKLESTSPKGGPPPPPPPPPRASSKRPAT 289
S + + + +S SS +
Sbjct: 750 SNSSDSSDSSDSSNSSDSSDSSDSSDSSDSSNSSDSNDSSNSSDSSDSSNSSDSSNSSDS 809
Query: 290 ADSPKPSAKKQKKSSSKGSRSAPGTSPRTSSSSSFSDKKPAKDK-SSTRGEKVKAE--SE 346
+DS S SS + S S +S SS SD D SS R + + S+
Sbjct: 810 SDSSDSSDSDSSNSSDSSNSSDSSDSSNSSDSSDSSDSSDGSDSDSSNRSDSSNSSDSSD 869
Query: 347 PREAKKALEVEESNSEDEASFKSESAQSSPSNSSSSSDSSSDSDFEPSQNHSQGPLRSMV 406
++ + + +S+ +E+S S+S+ SS S+ S SSDSS+ SD S N S S
Sbjct: 870 SSDSSNSSDSSDSSDSNESSNSSDSSDSSNSSDSDSSDSSNSSDSSDSSNSSDSSESSNS 929
Query: 407 EDLQSEESDEDDSSSGEEAAGKTNPGRDSRLSFSDSESD----NSADSSLPSREPPPPQK 462
D S SD +SS +++ +N S S S + SD NS+DSS S
Sbjct: 930 SD-NSNSSDSSNSSDSSDSSDSSNSSDSSNSSDSSNSSDSSDSNSSDSSDSSNSSDSSDS 988
Query: 463 PPPPNSKVSGRRSPESCS 480
+S S S S S
Sbjct: 989 SDSSDSSDSSDSSNSSDS 1006
Score = 78.2 bits (191), Expect = 2e-14
Identities = 68/285 (23%), Positives = 110/285 (38%), Gaps = 15/285 (5%)
Query: 167 SAFSDPKKTKPSHGSKDANKESSKTSKPHKVTKEHRERPRKDSESKSSSKELEREQAKSS 226
S+ SD + S S +N S S + + + DS+S SS E + + S
Sbjct: 582 SSDSDSSDSSDSDSSDSSNSSDSSDSSDSSDSSDSSDS--SDSKSDSSKSESDSSDSDSK 639
Query: 227 KDTSRKLGEGRLPKEEKAPPPKAAFKEPKMALKETKLESTSPKGGPPPPPPPPPRASSKR 286
D+S + + ++ ++ S+S +S+
Sbjct: 640 SDSSDSNSSDSSDNSDSSDSSNSSNSSDSSDSSDSSDSSSSSDSSNSSDSSDSSDSSNSS 699
Query: 287 PATADSPKPSAKKQKKSSSKGSRSAPGTSPRTSSSSSFSDKKPAKDKSSTRGEKVKAESE 346
++ S + S S S S+ S +S SS S+ + D S + ++S
Sbjct: 700 ESSDSSDSSDSDSSDSSDSSNSNSSDSDSSNSSDSSDSSNSSDSSDSSDSSNSSDSSDSS 759
Query: 347 PREAKKALEVEESNSEDEASFKSESAQSSPSNSSSSSDSSSDSDFEPSQNHSQGPLRSMV 406
+ SNS D + S S SNSS S+DSS+ SD S N S S
Sbjct: 760 ----------DSSNSSDSSDSSDSSDSSDSSNSSDSNDSSNSSDSSDSSNSSDSSNSSDS 809
Query: 407 EDLQSEESDEDDSSSGEEAAGKTNPGRDSRLSFSDSESDNSADSS 451
D S+ SD D S+S + + ++ DS S S+S +S+D S
Sbjct: 810 SD-SSDSSDSDSSNSSD--SSNSSDSSDSSNSSDSSDSSDSSDGS 851
Score = 77.8 bits (190), Expect = 2e-14
Identities = 76/313 (24%), Positives = 112/313 (35%), Gaps = 11/313 (3%)
Query: 170 SDPKKTKPSHGSKDANKES--SKTSKPHKVTKEHRERPRKDSESKSSSKELEREQAKSSK 227
SD + S S D+N+ S S +S + S+S SS + ++ +S
Sbjct: 871 SDSSNSSDSSDSSDSNESSNSSDSSDSSNSSDSDSSDSSNSSDSSDSSNSSDSSESSNSS 930
Query: 228 DTSRKLGEGRLPKEEKAPPPKAAFKEPKMALKETKLESTSPKGGPPPPPPPPPRASSKRP 287
D S + + + +S+ SS
Sbjct: 931 DNSNSSDSSNSSDSSDSSDSSNSSDSSNSSDSSNSSDSSDSNSSDSSD-------SSNSS 983
Query: 288 ATADSPKPSAKKQKKSSSKGSRSAPGTSPRTSSSSSFSDKKPAKDKSSTRGEKVKAESEP 347
++DS S SS S S+ + SS+SS S SS + +
Sbjct: 984 DSSDSSDSSDSSDSSDSSNSSDSSDSSDSSDSSNSSDSSNSSDSSNSSDSSDSSDSSDSS 1043
Query: 348 REAKKALEVEESNSEDEASFKSESAQSSPSNSSSSSDSSSDSDFEPSQNHSQGPLRSMVE 407
+ + + SNS D + S S S+SS SSDSS SD S N S S
Sbjct: 1044 DSSDSSDSSDSSNSSDSSDSSDSSDSSDSSDSSDSSDSSESSDSSDSSNSSDSSDSSDSS 1103
Query: 408 DLQSEESDEDDSSSGEEAAGKTNPGRDSRLSFSDSESDNSADSSLPSREPPPPQKPPPPN 467
D S+ SD DSS +++ ++ DS S S+S NS+DSS S +
Sbjct: 1104 D-SSDSSDSSDSSDSSDSSNSSD-SSDSSDSSDSSDSSNSSDSSDSSESSDSSDSSDSSD 1161
Query: 468 SKVSGRRSPESCS 480
S S S S S
Sbjct: 1162 SSDSSDSSDSSDS 1174
Score = 76.3 bits (186), Expect = 7e-14
Identities = 66/287 (22%), Positives = 114/287 (39%), Gaps = 7/287 (2%)
Query: 170 SDPKKTKPSHGSKDANKESSKTSKPHKVTKEHRERPRKDSESKSSSKELEREQAKSSKDT 229
S+ + S S D+++ S+ + + + S+S +SS + +S D+
Sbjct: 909 SNSSDSSDSSNSSDSSESSNSSDNSNSSDSSNSSDSSDSSDSSNSSDSSNSSDSSNSSDS 968
Query: 230 SRKLGEGRLPKEEKAPPPKAAFKEPKMALKETKLESTSPKGGPPPPPPPPPRASSKRPAT 289
S + ++ ++ S S +S+ ++
Sbjct: 969 SDSNSSDSSDSSNSSDSSDSSDSSDSSDSSDSSNSSDSSDSSDSSDSSNSSDSSNSSDSS 1028
Query: 290 ADSPKPSAKKQKKSSSKGSRSAPGTSPRTSSSSSFSDKKPAKDKSSTRGEKVKAES-EPR 348
S + SS S S +S SS SD + D S + +ES +
Sbjct: 1029 NSSDSSDSSDSSDSSDSSDSSDSSDSSNSSDSSDSSDSSDSSDSSDSSDSSDSSESSDSS 1088
Query: 349 EAKKALEVEESNSEDEASFKSESAQSSPS----NSSSSSDSSSDSDFEPSQNHSQGPLRS 404
++ + + +S+ ++S S+S+ SS S NSS SSDSS SD S N S S
Sbjct: 1089 DSSNSSDSSDSSDSSDSSDSSDSSDSSDSSDSSNSSDSSDSSDSSDSSDSSNSSDSSDSS 1148
Query: 405 MVEDLQSEESDEDDSSSGEEAAGKTNPGRDSRLSFSDSESDNSADSS 451
D S+ SD DSS +++ ++ DS S S+S +S+DSS
Sbjct: 1149 ESSD-SSDSSDSSDSSDSSDSSDSSD-SSDSSNSSDSSDSSDSSDSS 1193
Score = 74.7 bits (182), Expect = 2e-13
Identities = 68/313 (21%), Positives = 116/313 (37%), Gaps = 4/313 (1%)
Query: 170 SDPKKTKPSHGSKDANKESSKTSKPHKVTKEHRERPRKDSESKSSSKELEREQAKSSKDT 229
SD + S S D++ S + + + S SS + + S
Sbjct: 795 SDSSNSSDSSNSSDSSDSSDSSDSDSSNSSDSSNSSDSSDSSNSSDSSDSSDSSDGSDSD 854
Query: 230 SRKLGEGRLPKEEKAPPPKAAFKEPKMALKETKLESTSPKGGPPPPPPPPPRASSKRPAT 289
S + + + + + + ++S SS +
Sbjct: 855 SSNRSDSSNSSDSSDSSDSSNSSDSSDSSDSNESSNSSDSSDSSNSSDSDSSDSSNSSDS 914
Query: 290 ADSPKPSAKKQKKSSSKGSRSAPGTSPRTSSSSSFSDKKPAKDKSSTRGEKVKAESEPRE 349
+DS S + +SS S S+ S +S SS SD + D S++ ++S
Sbjct: 915 SDSSNSSDSSESSNSSDNSNSSD--SSNSSDSSDSSDSSNSSDSSNSSDSSNSSDSSDSN 972
Query: 350 AKKALEVEESNSEDEASFKSESAQSSPSNSSSSSDSSSDSDFEPSQNHSQGPLRSMVEDL 409
+ + + S+ ++S S+S+ SS S++SS S SSDS + + S S
Sbjct: 973 SSDSSDSSNSSDSSDSSDSSDSSDSSDSSNSSDSSDSSDSSDSSNSSDSSNSSDSSNSSD 1032
Query: 410 QSEESDEDDSSSGEEAAGKTNPGR--DSRLSFSDSESDNSADSSLPSREPPPPQKPPPPN 467
S+ SD DSS +++ ++ DS S S+S +S+DSS S N
Sbjct: 1033 SSDSSDSSDSSDSSDSSDSSDSSNSSDSSDSSDSSDSSDSSDSSDSSDSSESSDSSDSSN 1092
Query: 468 SKVSGRRSPESCS 480
S S S S S
Sbjct: 1093 SSDSSDSSDSSDS 1105
Score = 71.2 bits (173), Expect = 2e-12
Identities = 65/287 (22%), Positives = 106/287 (36%), Gaps = 5/287 (1%)
Query: 170 SDPKKTKPSHGSKDANKESSKTSKPHKVTKEHRERPRKDSESKSSSKELEREQAKSSKDT 229
SD + S S D++ S + + + S+S SS + + S D+
Sbjct: 992 SDSSDSSDSSNSSDSSDSSDSSDSSNSSDSSNSSDSSNSSDSSDSSDSSDSSDSSDSSDS 1051
Query: 230 SRKLGEGRLPKEEKAPPPKAAFKEPKMALKETKLESTSPKGGPPPPPPPPPRASSKRPAT 289
S + + + +S+ SS +
Sbjct: 1052 SDSSNSSDSSDSSDSSDSSDSSDSSDSSDSSESSDSSDSSNSSDSSDSSDSSDSSDSSDS 1111
Query: 290 ADSPKPSAKKQKKSSSKGSRSAPGTSPRTSSSSSFSDKKPAKDKSSTRGEKVKAESEPRE 349
+DS S SS S S+ + +S+SS SD + D S + ++S
Sbjct: 1112 SDSSDSSDSSNSSDSSDSSDSSDSSD--SSNSSDSSDSSESSDSSDSSDSSDSSDSSD-S 1168
Query: 350 AKKALEVEESNSEDEASFKSESAQSSPSNSSSSSDSSSDSDFEPSQNHSQGPLRSMVEDL 409
+ + + SNS D + S S S+SS SSDSS SD S + S S D
Sbjct: 1169 SDSSDSSDSSNSSDSSDSSDSSDSSDSSDSSDSSDSSDSSDSSDSSDSSDSSDSSDSSDS 1228
Query: 410 --QSEESDEDDSSSGEEAAGKTNPGRDSRLSFSDSESDNSADSSLPS 454
+E SD DSS +++ ++ S S S S+S++ +DS S
Sbjct: 1229 SDSNESSDSSDSSDSSDSSNSSDSSDSSDSSDSTSDSNDESDSQSKS 1275
Score = 70.1 bits (170), Expect = 5e-12
Identities = 69/291 (23%), Positives = 113/291 (38%), Gaps = 14/291 (4%)
Query: 170 SDPKKTKPSHGSKDANKESSKTSKPHKVTKEHRERPRKDSESKSSSKELEREQAKSSKDT 229
SD + S S D++ S + S+S +SS + + S D+
Sbjct: 1013 SDSSNSSDSSNSSDSSNSSDSSDSSDSSDSSDSSDSSDSSDSSNSSDSSDSSDSSDSSDS 1072
Query: 230 SRKLGEGRLPKEEKAPPPKAAFKEPKMALKETKLESTSPKGGPPPPPPPPPRASSKRPAT 289
S + + + + +S+ SS +
Sbjct: 1073 SDSSDSSDSSESSDSSDSSNSSDSSDSSDSSDSSDSSDSSDSSDSSDSSNSSDSSDSSDS 1132
Query: 290 ADSPKPSAKKQKKSSSKGSRSAPGT-SPRTSSSSSFSDKKPAKDKSSTRGEKVKAES--- 345
+DS S SS+ S S+ + S +S SS SD + D S++ ++S
Sbjct: 1133 SDSSDSSNSSDSSDSSESSDSSDSSDSSDSSDSSDSSDSSDSSDSSNSSDSSDSSDSSDS 1192
Query: 346 -EPREAKKALEVEESNSEDEASFKSESAQSSPSNSSS----SSDSSSDSDFEPSQNHSQG 400
+ ++ + + +S+ ++S S+S+ SS S+ SS SSDSS SD S N S
Sbjct: 1193 SDSSDSSDSSDSSDSSDSSDSSDSSDSSDSSDSSDSSDSNESSDSSDSSDSSDSSNSSDS 1252
Query: 401 PLRSMVEDLQSEESDEDDSSSGEEAAGKTNPGRDSRLSFSDSESDNSADSS 451
S D S+ +DE DS S ++ N G DS SDSE +S S+
Sbjct: 1253 SDSSDSSDSTSDSNDESDSQS--KSGNGNNNGSDSD---SDSEGSDSNHST 1298
Score = 68.9 bits (167), Expect = 1e-11
Identities = 62/292 (21%), Positives = 108/292 (36%), Gaps = 5/292 (1%)
Query: 170 SDPKKTKPSHGSKDANKESSKTSKPHKVTKEHRERPRKDSESKSSSKELEREQAKSSKDT 229
SD + S S D++ S + + S+S +SS + + S D+
Sbjct: 986 SDSSDSSDSSDSSDSSNSSDSSDSSDSSDSSNSSDSSNSSDSSNSSDSSDSSDSSDSSDS 1045
Query: 230 SRKLGEGRLPKEEKAPPPKAAFKEPKMALKETKLESTSPKGGPPPPPPPPPRASSKRPAT 289
S + + + +S+ SS +
Sbjct: 1046 SDSSDSSDSSNSSDSSDSSDSSDSSDSSDSSDSSDSSESSDSSDSSNSSDSSDSSDSSDS 1105
Query: 290 ADSPKPSAKKQKKSSSKGSRSAPGTSPRTSSSSSFSDKKPAKDKSSTRGEKVKAESEPRE 349
+DS S SS S S+ + SS SS S +SS + S+ +
Sbjct: 1106 SDSSDSSDSSDSSDSSNSSDSSDSSDSSDSSDSSNSSDSSDSSESSDSSDS----SDSSD 1161
Query: 350 AKKALEVEESNSEDEASFKSESAQSSPSNSSSSSDSSSDSDFEPSQNHSQGPLRSMVEDL 409
+ + + +S+ ++S S+S+ SS S+ SS S SSDS + S S
Sbjct: 1162 SSDSSDSSDSSDSSDSSNSSDSSDSSDSSDSSDSSDSSDSSDSSDSSDSSDSSDSSDSSD 1221
Query: 410 QSEESDEDDSSSGEEAAGKTNPGRDSRLSFSDSESDNSADSSLPSREPPPPQ 461
S+ SD DS+ +++ ++ DS S S+S +S+DS+ S + Q
Sbjct: 1222 SSDSSDSSDSNESSDSSDSSD-SSDSSNSSDSSDSSDSSDSTSDSNDESDSQ 1272
Score = 63.5 bits (153), Expect = 5e-10
Identities = 55/262 (20%), Positives = 98/262 (37%), Gaps = 3/262 (1%)
Query: 170 SDPKKTKPSHGSKDANKESSKTSKPHKVTKEHRERPRKDSESKSSSKELEREQAKSSKDT 229
SD + S S D++ S + S+S SS + + S D+
Sbjct: 1040 SDSSDSSDSSDSSDSSNSSDSSDSSDSSDSSDSSDSSDSSDSSESSDSSDSSNSSDSSDS 1099
Query: 230 SRKLGEGRLPKEEKAPPPKAAFKEPKMALKETKLESTSPKGGPPPPPPPPPRASSKRPAT 289
S + + + +S+ SS +
Sbjct: 1100 SDSSDSSDSSDSSDSSDSSDSSNSSDSSDSSDSSDSSDSSNSSDSSDSSESSDSSDSSDS 1159
Query: 290 ADSPKPSAKKQKKSSSKGSRSAPGT-SPRTSSSSSFSDKKPAKDKSSTRGEKVKAESEPR 348
+DS S SS S S+ + S +S SS SD + D S + ++S
Sbjct: 1160 SDSSDSSDSSDSSDSSDSSNSSDSSDSSDSSDSSDSSDSSDSSDSSDSSDSSDSSDSS-- 1217
Query: 349 EAKKALEVEESNSEDEASFKSESAQSSPSNSSSSSDSSSDSDFEPSQNHSQGPLRSMVED 408
++ + + +S+ +E+S S+S+ SS S++SS S SSDS S ++ + +S +
Sbjct: 1218 DSSDSSDSSDSSDSNESSDSSDSSDSSDSSNSSDSSDSSDSSDSTSDSNDESDSQSKSGN 1277
Query: 409 LQSEESDEDDSSSGEEAAGKTN 430
+ SD D S G ++ T+
Sbjct: 1278 GNNNGSDSDSDSEGSDSNHSTS 1299
Score = 52.0 bits (123), Expect = 1e-06
Identities = 67/332 (20%), Positives = 122/332 (36%), Gaps = 46/332 (13%)
Query: 146 EGADTVSRPSPDYPMLPTIPLSAFSDPKKTKPSHGSKDANKESSKTSKP----------- 194
EG D D + + DP+ + H D +K S
Sbjct: 281 EGQDHGKEDDHDSSIGQNSDSKEYYDPEGKEDPHNEVDGDKTSKSEENSAGIPEDNGSQR 340
Query: 195 --------HKVTKEHRERPRKDSES----KSSSKELE-REQAKSSKDTSRKLGEGRLPKE 241
H+ +K R K+SE+ KS K +E + + +++ ++++G+G KE
Sbjct: 341 IEDTQKLNHRESKRVENRITKESETHAVGKSQDKGIEIKGPSSGNRNITKEVGKGNEGKE 400
Query: 242 EKAPPPKAAFK-EPKMALKETKLESTSPKGGPPPPPPPPPRASSKRPATADSPKPSAKKQ 300
+K K K + +E K P + +++ S
Sbjct: 401 DKGQHGMILGKGNVKTQGEVVNIEGPGQKSEP-----------GNKVGHSNTGSDSNSDG 449
Query: 301 KKSSSKGSRSAPGTSPRTSSSSSFSD--KKPAKDKSSTRGEKVKAESEPREAKKALEVEE 358
S +S G P +S S+ +D + + SS+RG+ E ++ + +
Sbjct: 450 YDSYDFDDKSMQGDDPNSSDESNGNDDANSESDNNSSSRGDASYNSDESKDNGNGSDSKG 509
Query: 359 SNSEDEASFKSESAQSSPSNSSSSSDSSSDSDFEPSQNHSQGPLRSMVEDLQSEESDEDD 418
+ +D S + S N ++ +D + SD ++ S S S SD D
Sbjct: 510 AEDDDSDSTSDTNNSDSNGNGNNGNDDNDKSDSGKGKSDSSDSDSSD----SSNSSDSSD 565
Query: 419 SSSGEEAAGKTNPGRDSRLSFSDSESDNSADS 450
SS + + ++ DS SDS+S +S+DS
Sbjct: 566 SSDSDSSDSNSSSDSDS----SDSDSSDSSDS 593
Score = 43.5 bits (101), Expect = 5e-04
Identities = 62/308 (20%), Positives = 113/308 (36%), Gaps = 37/308 (12%)
Query: 171 DPKKTKPSHGSKDANKESSKTSKPHKVTKEHRERPRKDSESKS----SSKELEREQAKSS 226
D + + +G +N + + H +H ++S+SK KE +
Sbjct: 261 DDEDEEAGNGKDSSNNSKGQEGQDHGKEDDHDSSIGQNSDSKEYYDPEGKEDPHNEVDGD 320
Query: 227 KDTSRKLGEGRLPKEEKAP----PPKAAFKEPKMALKETKLES-------TSPKGGPPPP 275
K + + +P++ + K +E K ES + KG
Sbjct: 321 KTSKSEENSAGIPEDNGSQRIEDTQKLNHRESKRVENRITKESETHAVGKSQDKGIEIKG 380
Query: 276 PPPPPRASSKRPATADSPKPSAKKQKKSSSKGSRSAPGTSPRTSSSSSFSDKKPAKDKSS 335
P R +K + K + KG+ G S+ S+
Sbjct: 381 PSSGNRNITKEVGKGNEGKEDKGQHGMILGKGNVKTQGEVVNIEGPGQKSEPGNKVGHSN 440
Query: 336 TRGEKVKAESEPREAK-KALEVEESNSEDEASFKSESAQSSPSNSSSSSDSSSDSDFEPS 394
T + + + K+++ ++ NS DE++ ++ S +NSSS D+S +SD S
Sbjct: 441 TGSDSNSDGYDSYDFDDKSMQGDDPNSSDESNGNDDANSESDNNSSSRGDASYNSD--ES 498
Query: 395 QNHSQGPLRSMVEDLQSEESDEDDSSS-----GEEAAGKTNPGR------DSRLSFSDSE 443
+++ G S+ +++DDS S ++ G N G DS SDS
Sbjct: 499 KDNGNGS--------DSKGAEDDDSDSTSDTNNSDSNGNGNNGNDDNDKSDSGKGKSDSS 550
Query: 444 SDNSADSS 451
+S+DSS
Sbjct: 551 DSDSSDSS 558
Score = 36.6 bits (83), Expect = 0.062
Identities = 32/168 (19%), Positives = 73/168 (43%), Gaps = 31/168 (18%)
Query: 316 PRTSSSSSFSDKKPAKDKSSTRGEKVKAESEP-----REAKKALEVEESNSEDEASFKSE 370
P+ + S++ +D + ++S R E +E P R K EV ED +
Sbjct: 184 PQVAGSNNSTDNEDEIIENSCRNEGNTSEITPQINSKRNGTKEAEVTPGTGEDAGL---D 240
Query: 371 SAQSSPSNSSSSSDSSSDSDFEPSQNHSQGPLRSMVEDLQSEESDEDDSSSGEEAAGKTN 430
++ SPS + + D ED S + +++++ +G++++ +
Sbjct: 241 NSDGSPSGNGADED----------------------EDEGSGDDEDEEAGNGKDSSNNSK 278
Query: 431 PGRDSRLSFSDSESDNSADSSLPSREPPPPQKPPPPNSKVSGRRSPES 478
G++ + + + D+S + S+E P+ P+++V G ++ +S
Sbjct: 279 -GQEGQDHGKEDDHDSSIGQNSDSKEYYDPEGKEDPHNEVDGDKTSKS 325
Score = 33.5 bits (75), Expect = 0.53
Identities = 47/277 (16%), Positives = 101/277 (36%), Gaps = 21/277 (7%)
Query: 178 SHGSKDANKESSKTSKPHKVTKEHRERPRKDSESKSSSKELEREQAKSSKDTSRKLGEGR 237
S GS N + ++ KDS + S +E + + D+S +G+
Sbjct: 242 SDGSPSGNGADEDEDEGSGDDEDEEAGNGKDSSNNSKGQEGQDHGKEDDHDSS--IGQNS 299
Query: 238 LPKEEKAPPPKAAFKEPKMALKETKLESTSPKGGPPPPPPPPPRASSKRPATADSPKPSA 297
KE P K ++P + K + P R D+ K +
Sbjct: 300 DSKEYYDPEGK---EDPHNEVDGDKTSKSEENSAGIPEDNGSQRIE-------DTQKLNH 349
Query: 298 KKQKKSSSKGSRSAPGTSPRTSSSSSFSDKKPAKDKSSTRGEKVKA-ESEPREAKKALEV 356
++ K+ ++ ++ + + S K P+ + E K E + + + + +
Sbjct: 350 RESKRVENRITKESETHAVGKSQDKGIEIKGPSSGNRNITKEVGKGNEGKEDKGQHGMIL 409
Query: 357 EESNSEDEA---SFKSESAQSSPSNSSSSSDSSSDSDFEPSQNHSQGPLRSMVEDLQSEE 413
+ N + + + + +S P N S++ SDS+ + ++ + +Q ++
Sbjct: 410 GKGNVKTQGEVVNIEGPGQKSEPGNKVGHSNTGSDSNSDGYDSYDFDD-----KSMQGDD 464
Query: 414 SDEDDSSSGEEAAGKTNPGRDSRLSFSDSESDNSADS 450
+ D S+G + A + S + SD S D+
Sbjct: 465 PNSSDESNGNDDANSESDNNSSSRGDASYNSDESKDN 501
>gi|169658378 trinucleotide repeat containing 18 [Homo sapiens]
Length = 2968
Score = 85.9 bits (211), Expect = 9e-17
Identities = 97/366 (26%), Positives = 145/366 (39%), Gaps = 52/366 (14%)
Query: 152 SRPSPD-YPMLPTIPLSAFSDPKKTKPSHGSKDANKESSKTSKPHKVTKEHRERPRKDSE 210
S P+P+ + LP S P T P+ K K + + PR+ E
Sbjct: 2405 SCPAPEPFAELPAPATSLAPAPLITMPA--------TRPKPKKARAAEESGAKGPRRPGE 2456
Query: 211 SKSSSKELEREQAKSSKDTSRKLGEGRLPKEEKAPPPKAAFKEPKMALKETKLESTSPKG 270
+L+ E S K S+K E L +E+ P ++EPK L L S P
Sbjct: 2457 EAELLVKLDHEGVTSPK--SKKAKEALLLRED---PGAGGWQEPKSLLS---LGSYPPAA 2508
Query: 271 GPPPPPPPPPRASS-------------------KRPATADSPKPSAKKQKKSSSKGSRSA 311
G P P P+A+ K P A + + A++ + SSS S S+
Sbjct: 2509 GSSEPKAPWPKATDGDLAQEPGPGLTFEDSGNPKSPDKAQAEQDGAEESESSSSSSSGSS 2568
Query: 312 PGTSPRTSSSSSFSDKKPAKDKSS-----TRGEKVKAESEPREAKKALEVEESNSEDEAS 366
+S +SSS S ++ + DK+ T G A S + + S+S +S
Sbjct: 2569 SSSSS-SSSSGSETEGEEEGDKNGDGGCGTGGRNCSAASSRAASPASSSSSSSSSSSSSS 2627
Query: 367 FKSESAQSSPSNSSSSSDSSSDSDFEPSQNHSQGPLRSMVEDLQSEESDEDDSSSGEEAA 426
S S+ SS S+SSSSS SSS S S + S S S +DED S S ++ A
Sbjct: 2628 SSSSSSSSSSSSSSSSSSSSSSSSSSSSSSSSSS--SSSSSSSSSSTTDEDSSCSSDDEA 2685
Query: 427 GKTNPGRDSRLSFSDSESDNSADSSLPSRE-------PPPPQKPPP-PNSKVSGRRSPES 478
S + +++ A + PS P PQ PPP P + + +
Sbjct: 2686 APAPTAGPSAQAALPTKATKQAGKARPSAHSPGKKTPAPQPQAPPPQPTQPLQPKAQAGA 2745
Query: 479 CSKPEK 484
S+P+K
Sbjct: 2746 KSRPKK 2751
Score = 55.1 bits (131), Expect = 2e-07
Identities = 95/417 (22%), Positives = 137/417 (32%), Gaps = 97/417 (23%)
Query: 156 PDYPMLPTIPLSAFSDPKKTKPSHGSKDANKESSKTSKPHKVTKEHRERPRKDSESKSSS 215
PDY + P A P A + S KTSK K+ ++ +K+
Sbjct: 2282 PDYKIQCAEPSPALLVPS----------AKRRSRKTSKDTGEGKDGGTAGSEEPGAKARG 2331
Query: 216 KELEREQAKSSKDTSRKLGEGRLPKEEKAPPPKAAFKEPKMALKETKLESTSPKGGPPPP 275
+ + AK+ D + L EG P +E P A K++ E + P
Sbjct: 2332 RG-RKPSAKAKGDRAATLEEGN-PTDEVPSTPLALEPSSTPGSKKSPPEPVDKRAKAPKA 2389
Query: 276 PPPPPRASSKRPATADSPKP-----------------------------SAKKQKKSSSK 306
P PP+ S PA P P A+ ++S +K
Sbjct: 2390 RPAPPQPSPAPPAFTSCPAPEPFAELPAPATSLAPAPLITMPATRPKPKKARAAEESGAK 2449
Query: 307 GSRSAPG--------------TSPRTSSSS---------------------SFSDKKPAK 331
G R PG TSP++ + S PA
Sbjct: 2450 GPR-RPGEEAELLVKLDHEGVTSPKSKKAKEALLLREDPGAGGWQEPKSLLSLGSYPPAA 2508
Query: 332 DKSSTRGEKVKAESE--PREAKKALEVEES---NSEDEASFKSESAQSSPSNSSSSSDSS 386
S + KA +E L E+S S D+A + + A+ S S+SSSSS SS
Sbjct: 2509 GSSEPKAPWPKATDGDLAQEPGPGLTFEDSGNPKSPDKAQAEQDGAEESESSSSSSSGSS 2568
Query: 387 SDSDFEPSQNHSQGPLRSMVEDLQSEESDEDDSSSGEEAAGKTNPGRDSRL-----SFSD 441
S S S + S G + + EE + + G G+ SR S S
Sbjct: 2569 SSS----SSSSSSG------SETEGEEEGDKNGDGGCGTGGRNCSAASSRAASPASSSSS 2618
Query: 442 SESDNSADSSLPSREPPPPQKPPPPNSKVSGRRSPESCSKPEKILKKGTYDKAYTDE 498
S S +S+ SS S +S S S S S + + TDE
Sbjct: 2619 SSSSSSSSSSSSSSSSSSSSSSSSSSSSSSSSSSSSSSSSSSSSSSSSSSSSSTTDE 2675
Score = 39.7 bits (91), Expect = 0.007
Identities = 32/148 (21%), Positives = 50/148 (33%), Gaps = 2/148 (1%)
Query: 167 SAFSDPKKTKPSHGSKDANKESSKTSKPHKVTKEHRERPRKDSESKSSSKELEREQAKSS 226
S+ S + S S ++ SS +S + S S SSS + +
Sbjct: 2615 SSSSSSSSSSSSSSSSSSSSSSSSSSSSSSSSSSSSSSSSSSSSSSSSSSSSSSSSSTTD 2674
Query: 227 KDTSRKLGEGRLPKEEKAPPPKAAFKEPKMALKETKLESTSPKGGPPPPPPPPPRASSKR 286
+D+S + P P +AA P A K+ S P P P+A +
Sbjct: 2675 EDSSCSSDDEAAPAPTAGPSAQAAL--PTKATKQAGKARPSAHSPGKKTPAPQPQAPPPQ 2732
Query: 287 PATADSPKPSAKKQKKSSSKGSRSAPGT 314
P PK A + + + P T
Sbjct: 2733 PTQPLQPKAQAGAKSRPKKREGVHLPTT 2760
Score = 34.7 bits (78), Expect = 0.24
Identities = 35/133 (26%), Positives = 48/133 (36%), Gaps = 21/133 (15%)
Query: 177 PSHGSKDANKESSKTSKPHKV---TKEHRERPRKD--------------SESKSSSKELE 219
P G KD + S P V T+E R R+D +ESK+ + L+
Sbjct: 218 PLFGKKDPRARGEEASGPRGVVDLTQEARAEGRQDRGPPRLAERLSPFLAESKTKNAALQ 277
Query: 220 REQAKSSKDTSRKLGEGRLPKEEKAPPPKAAFKEPKMAL----KETKLESTSPKGGPPPP 275
+ +G L E K A ++ + A ET L P P PP
Sbjct: 278 PSVLTMCNGGAGDVGLPALVAEAGRGGAKEAARQDEGARLLRRTETLLPGPRPCPSPLPP 337
Query: 276 PPPPPRASSKRPA 288
PP PP+ PA
Sbjct: 338 PPAPPKGPPAPPA 350
Score = 33.9 bits (76), Expect = 0.40
Identities = 89/397 (22%), Positives = 141/397 (35%), Gaps = 84/397 (21%)
Query: 150 TVSRPSPDYPMLPTIPLSAFSDPKKT-KPSHGSKDANKESSKTSKPHKVTKEHRERPRKD 208
+++R P P T SA S P+K K H S + +S TS +++ R+R +
Sbjct: 1520 SLARRGPGRPRKRTHAPSALSPPRKRGKSGHSSGKLSSKSLLTSDDYELGAGIRKRHKGS 1579
Query: 209 SESKSS----SKELEREQAKSSKDTSRK-LGEGRLPKEEKAPPPKAAFKEPKMAL---KE 260
E + K R Q + S + + ++ K++ A + + AL K+
Sbjct: 1580 EEEHDALIGMGKARGRNQTWDEHEASSDFISQLKIKKKKMASDQEQLASKLDKALSLTKQ 1639
Query: 261 TKLES----TSPKGGPPPPP--------PPPPRASSKRPATADS------------PKPS 296
KL+S + GG P R A A K +
Sbjct: 1640 DKLKSPFKFSDSAGGKSKTSGGCGRYLTPYDSLLGKNRKALAKGLGLSLKSSREGKHKRA 1699
Query: 297 AKKQKKSSSKGSRSAPGT--SPRTSSSSSFS-------------DKKPAKDKSSTR---- 337
AK +K +R P + SP S SS+S D+ PA+ SS++
Sbjct: 1700 AKTRKMEVGFKARGQPKSAHSPFASEVSSYSYNTDSEEDEEFLKDEWPAQGPSSSKLTPS 1759
Query: 338 ------GEKVKAESEPREAKKALEVEESNSEDEASFKSES------AQSSPSNSSSSSDS 385
+ KA P+ K+ L + A+ + + + S+ S SS+
Sbjct: 1760 LLCSMVAKNSKAAGGPKLTKRGLAAPRTLKPKPATSRKQPFCLLLREAEARSSFSDSSEE 1819
Query: 386 SSDSDFEPSQNHSQGPLRSMVEDLQSEESDEDDSSSGEEAAGKTNPGRDSRLSFSDSESD 445
S D D S E+ + EE +E+D +SG G R+ LS ES
Sbjct: 1820 SFDQD------------ESSEEEDEEEELEEEDEASG---GGYRLGARERALSPGLEESG 1864
Query: 446 -----NSADSSLPSREPPPPQKPPPPNSKVSGRRSPE 477
A S+LPS P +K R+ E
Sbjct: 1865 LGLLARFAASALPSPTVGPSLSVVQLEAKQKARKKEE 1901
>gi|148596949 nucleolar and coiled-body phosphoprotein 1 [Homo
sapiens]
Length = 699
Score = 84.0 bits (206), Expect = 3e-16
Identities = 85/311 (27%), Positives = 128/311 (41%), Gaps = 38/311 (12%)
Query: 173 KKTKPSHGSKDANKESSKTSKP---------HKVTKEHRERPRKDSESKSSSKELEREQA 223
KK S S+D+++E + P +V + K SES SS + + +
Sbjct: 79 KKKASSSDSEDSSEEEEEVQGPPAKKAAVPAKRVGLPPGKAAAKASESSSSEESSDDDDE 138
Query: 224 KSSKDTSRKLGEGRLPKEEKAPPPKAAFKEPKMALKETKLESTSPKGGPPPPPPPPPRAS 283
+ K + G K KAPP KA + ++ E PK P P +A
Sbjct: 139 EDQKKQPVQKGVKPQAKAAKAPPKKAKSSDSD---SDSSSEDEPPKNQKPKITPVTVKAQ 195
Query: 284 SKRPATADSPKPSAKKQKKSSSKGSRSAPGTSPRTSSSSSFSDKKPAKDKSSTRGEKVKA 343
+K P PKP+ K ++ K + S+ +S +SS S +K A K + ++V A
Sbjct: 196 TKAP-----PKPARAAPKIANGKAASSSSSSSSSSSSDDSEEEKAAATPKKTVPKKQVVA 250
Query: 344 ESEPREAKKALEVEESNSEDEASFKSESAQSSPSNSSSSSDSSSDSDFEPSQNHSQG--P 401
++ + A +S+S +++S E Q P + SS P S G P
Sbjct: 251 KAPVKAA--TTPTRKSSSSEDSSSDEEEEQKKPMKNKPGPYSSVPPPSAPPPKKSLGTQP 308
Query: 402 LRSMVEDLQSEESDED-----DSSSGEE-----------AAGKTNPGRDSRLSFSD-SES 444
+ VE Q ES ED DSSS EE A K P + + S SD S+S
Sbjct: 309 PKKAVEKQQPVESSEDSSDESDSSSEEEKKPPTKAVVSKATTKPPPAKKAAESSSDSSDS 368
Query: 445 DNSADSSLPSR 455
D+S D PS+
Sbjct: 369 DSSEDDEAPSK 379
Score = 77.8 bits (190), Expect = 2e-14
Identities = 96/377 (25%), Positives = 145/377 (38%), Gaps = 74/377 (19%)
Query: 167 SAFSDPKKTKPSHGSKDANKESS--KTSKPHKVT------------KEHRERPR------ 206
+A + PKK K S D++ E K KP K+T K R P+
Sbjct: 156 AAKAPPKKAKSSDSDSDSSSEDEPPKNQKP-KITPVTVKAQTKAPPKPARAAPKIANGKA 214
Query: 207 ----KDSESKSSSKELEREQAKSS--KDTSRKLGEGRLPKEEKAPPPKAAFKEPKMALKE 260
S S SSS + E E+A ++ K +K + P + P + + + E
Sbjct: 215 ASSSSSSSSSSSSDDSEEEKAAATPKKTVPKKQVVAKAPVKAATTPTRKSSSSEDSSSDE 274
Query: 261 TKLESTSPKGGP------PPPPPPPPRASSKRPATADSPKPSAKKQKKSSSKGSRSAPGT 314
+ + K P PPP PPP K+ PK + +KQ+ S S
Sbjct: 275 EEEQKKPMKNKPGPYSSVPPPSAPPP----KKSLGTQPPKKAVEKQQPVESSEDSSDE-- 328
Query: 315 SPRTSSSSSFSDKKPAKDKSSTRGEKVKAESEPREAKKALEVEESNSEDEASFKSESAQS 374
S SSS +KKP T+ KA ++P AKKA E +S+ ++S E+
Sbjct: 329 ----SDSSSEEEKKPP-----TKAVVSKATTKPPPAKKAAESSSDSSDSDSSEDDEAPSK 379
Query: 375 SPSNSSSSSDSSSDSDFEPSQNHSQGPLRS-------MVEDLQSEESDEDDSSSGEEAAG 427
+ +SS+ + + P+ + P + + S S+E+ SSS EE
Sbjct: 380 PAGTTKNSSNKPAVTTKSPAVKPAAAPKQPVGGGQKLLTRKADSSSSEEESSSSEEEKTK 439
Query: 428 K----TNPGRDSRLSFS-----------DSESDNSADSSLPSREPPPPQKPPPPNSKVSG 472
K T P ++ + S DS SD+ + SS E KV+G
Sbjct: 440 KMVATTKPKATAKAALSLPAKQAPQGSRDSSSDSDSSSSEEEEEKTSKSAVKKKPQKVAG 499
Query: 473 RRSPESCSKPEKILKKG 489
+P SKP KKG
Sbjct: 500 GAAP---SKPAS-AKKG 512
Score = 68.9 bits (167), Expect = 1e-11
Identities = 87/359 (24%), Positives = 130/359 (36%), Gaps = 51/359 (14%)
Query: 148 ADTVSRPSPDYPMLPTIPLSAFSDPKKTKPSHGSKDANKESSKTSKPHKVT--------- 198
A T + P P P I + + S S D ++E + P K
Sbjct: 194 AQTKAPPKPARAA-PKIANGKAASSSSSSSSSSSSDDSEEEKAAATPKKTVPKKQVVAKA 252
Query: 199 --KEHRERPRKDSESKSSSKELEREQAKSSKDTSRKLGEGRLP------KEEKAPPPKAA 250
K RK S S+ SS + E EQ K K+ P K PPK A
Sbjct: 253 PVKAATTPTRKSSSSEDSSSDEEEEQKKPMKNKPGPYSSVPPPSAPPPKKSLGTQPPKKA 312
Query: 251 FKEPKMALKETKLESTSPKGGPPPPPPPPPRASSKRPATADSPKPSAKKQKKSSSKGSRS 310
++ + S PP SK A + P AKK +SSS S S
Sbjct: 313 VEKQQPVESSEDSSDESDSSSEEEKKPPTKAVVSK----ATTKPPPAKKAAESSSDSSDS 368
Query: 311 -------AP----GTSPRTSSSSSFSDKKPAKDKSSTRGEKVKAESE--PREAKKALEVE 357
AP GT+ +S+ + + K PA ++ + V + R+A + E
Sbjct: 369 DSSEDDEAPSKPAGTTKNSSNKPAVTTKSPAVKPAAAPKQPVGGGQKLLTRKADSSSSEE 428
Query: 358 ESNSEDEASFKSESAQSSPSNSS-------------SSSDSSSDSDFEPSQNHSQGPLRS 404
ES+S +E K A + P ++ S DSSSDSD S+ + +S
Sbjct: 429 ESSSSEEEKTKKMVATTKPKATAKAALSLPAKQAPQGSRDSSSDSDSSSSEEEEEKTSKS 488
Query: 405 MVEDLQSEESDEDDSSSGEEAAGKTNPGRDSRLSFSDSESDNSADSSLPSREPPPPQKP 463
V+ + + ++ + A+ K S S SD S+ + L + P PQ P
Sbjct: 489 AVK--KKPQKVAGGAAPSKPASAKKGKAESSNSSSSDDSSEEE-EEKLKGKGSPRPQAP 544
Score = 52.8 bits (125), Expect = 8e-07
Identities = 79/342 (23%), Positives = 134/342 (39%), Gaps = 63/342 (18%)
Query: 173 KKTKPSHGSKDANKESSKTSKPHK-------VTKEHRERPRKDSESKSSSKELEREQAKS 225
+K +P S+D++ ES +S+ K V+K + P ++SSS + + ++
Sbjct: 314 EKQQPVESSEDSSDESDSSSEEEKKPPTKAVVSKATTKPPPAKKAAESSSDSSDSDSSED 373
Query: 226 SKDTSRKLGEGRLPKEEKAPPPKAAFKEPKMALKETKLESTSPKGGPPPPPPPPPRASSK 285
+ S+ G + + A K+ +P A K+ P GG +SS
Sbjct: 374 DEAPSKPAGTTKNSSNKPAVTTKSPAVKPAAAPKQ-------PVGGGQKLLTRKADSSSS 426
Query: 286 RPATADSPKPSAKK-----QKKSSSKGSRSAPG----------TSPRTSSSSSFSDKKPA 330
++ S + KK + K+++K + S P +S SSSS ++K +
Sbjct: 427 EEESSSSEEEKTKKMVATTKPKATAKAALSLPAKQAPQGSRDSSSDSDSSSSEEEEEKTS 486
Query: 331 KDKSSTRGEKVK---AESEPREAKKALEVEESNSEDEASFKSESAQSSPSNSSSSSDSSS 387
K + +KV A S+P AKK K+ES SNSSSS DSS
Sbjct: 487 KSAVKKKPQKVAGGAAPSKPASAKKG--------------KAES-----SNSSSSDDSSE 527
Query: 388 DSDFEPSQNHS---QGPLRSMVEDLQSEESDEDDSSSGEEAAGKTNPGRDSRLSFSDSES 444
+ + + S Q P + L ++ +S EE K + + S S S
Sbjct: 528 EEEEKLKGKGSPRPQAPKANGTSALTAQNGKAAKNSEEEEEEKK-----KAAVVVSKSGS 582
Query: 445 DNSADSSLPSREPPPPQ----KPPPPNSKVSGRRSPESCSKP 482
+ ++E PQ K PN+ ++ + S P
Sbjct: 583 LKKRKQNEAAKEAETPQAKKIKLQTPNTFPKRKKGEKRASSP 624
Score = 48.1 bits (113), Expect = 2e-05
Identities = 46/229 (20%), Positives = 86/229 (37%), Gaps = 14/229 (6%)
Query: 168 AFSDPKKTKPSHGSKDANKESSKTSKPHKVTKEHRERPRK-----------DSESKSSSK 216
A S + + S ++ K+ T+KP K P K DS+S SS +
Sbjct: 421 ADSSSSEEESSSSEEEKTKKMVATTKPKATAKAALSLPAKQAPQGSRDSSSDSDSSSSEE 480
Query: 217 ELEREQAKSSKDTSRKLGEGRLPKEEKAPPPKAAFKEPKMALKETKLESTSPKGGPPPPP 276
E E+ + K +K+ G P + + A + ++ E G P
Sbjct: 481 EEEKTSKSAVKKKPQKVAGGAAPSKPASAKKGKAESSNSSSSDDSSEEEEEKLKGKGSPR 540
Query: 277 PPPPRASSKRPATADSPKPSAKKQKKSSSKGSRSAPGTSPRTSSSSSFSDKKPAKDKSST 336
P P+A+ TA + K A K + + + A ++ S + AK+ +
Sbjct: 541 PQAPKANGTSALTAQNGK--AAKNSEEEEEEKKKAAVVVSKSGSLKKRKQNEAAKEAETP 598
Query: 337 RGEKVKAESEPREAKKALEVEESNSEDEASFKSESAQSSPSNSSSSSDS 385
+ +K+K ++ P K + E+ S + E + + +S D+
Sbjct: 599 QAKKIKLQT-PNTFPKRKKGEKRASSPFRRVREEEIEVDSRVADNSFDA 646
Score = 42.7 bits (99), Expect = 9e-04
Identities = 47/189 (24%), Positives = 74/189 (39%), Gaps = 23/189 (12%)
Query: 295 PSAKK-QKKSSSKGSRSAPGTSPRTSSSSSFSDKKPAKDKSSTRGEKVKAESEPREAKKA 353
P AKK +KK+SS S + + PAK G+ SE ++
Sbjct: 73 PVAKKAKKKASSSDSEDSSEEEEEVQGPPAKKAAVPAKRVGLPPGKAAAKASESSSSE-- 130
Query: 354 LEVEESNSEDEASFKSESAQS----------SPSNSSSSSDSSSDSDFEPSQNHSQGP-L 402
E S+ +DE K + Q +P + SSDS SDS E +Q P +
Sbjct: 131 ---ESSDDDDEEDQKKQPVQKGVKPQAKAAKAPPKKAKSSDSDSDSSSEDEPPKNQKPKI 187
Query: 403 RSMVEDLQSEESDEDDSSSGEEAAGKTNPGRDSRLSFSDSESDNSADSSLPSREPPPPQK 462
+ Q++ + ++ + A GK + S S S S +S+D S + P+K
Sbjct: 188 TPVTVKAQTKAPPKPARAAPKIANGK------AASSSSSSSSSSSSDDSEEEKAAATPKK 241
Query: 463 PPPPNSKVS 471
P V+
Sbjct: 242 TVPKKQVVA 250
Score = 40.4 bits (93), Expect = 0.004
Identities = 41/188 (21%), Positives = 79/188 (42%), Gaps = 14/188 (7%)
Query: 311 APGTSPRTSSSSSFSDKKPAKDKSSTRGEKVKAESEPREAKKALEVEESNSEDEASFKSE 370
A G + + +++SS D KS+ E+ K ++ AKKA + S+ +++S + E
Sbjct: 37 ATGATQQDANASSLLDIYSFWLKSAKVPER-KLQANGPVAKKAKKKASSSDSEDSSEEEE 95
Query: 371 SAQSSPSNSSSSSDSSSDSDFEPSQNHSQGPLRSMVEDLQSEESDEDDSSS----GEEAA 426
Q P+ ++ + P + ++ S E+ ++ +ED G +
Sbjct: 96 EVQGPPAKKAAVP--AKRVGLPPGKAAAKASESSSSEESSDDDDEEDQKKQPVQKGVKPQ 153
Query: 427 GKTNPGRDSRLSFSDSESDNSADSSLPSREPPPPQKPPPPNSKVSGRRSPESCSKPEKIL 486
K + SDS+SD+S+ E PP+ P + V+ + ++ KP +
Sbjct: 154 AKAAKAPPKKAKSSDSDSDSSS-------EDEPPKNQKPKITPVTVKAQTKAPPKPARAA 206
Query: 487 KKGTYDKA 494
K KA
Sbjct: 207 PKIANGKA 214
>gi|32483416 neurofilament, heavy polypeptide 200kDa [Homo sapiens]
Length = 1020
Score = 74.3 bits (181), Expect = 3e-13
Identities = 84/352 (23%), Positives = 143/352 (40%), Gaps = 37/352 (10%)
Query: 174 KTKPSHGSKDANKESSKTSKPHKVTKEHRERPRKDSESKSSSKELEREQAKS-SKDTSRK 232
K+ P+ + KE+ K + + P K+ E+KS ++ E+AKS +K+ ++
Sbjct: 502 KSPPAEEAASPEKEAKSPVKEEAKSPAEAKSPEKE-EAKSPAEVKSPEKAKSPAKEEAKS 560
Query: 233 LGEGRLPKEEKAPPPKAAFKEPKMALKETKLESTSP-KGGPPPPPPPPPRASSKRPATAD 291
E + P++E+A P A K P+ A K E+ SP + P P + +K PA A
Sbjct: 561 PPEAKSPEKEEAKSP-AEVKSPEKAKSPAKEEAKSPAEAKSPEKAKSPVKEEAKSPAEAK 619
Query: 292 SP-----KPSAKKQKKSSSKGSRSAPGTSPRTSSSSSFSD-KKPAKDKSSTRGEK----- 340
SP K A+ + +K SP + S + K P K KS + E
Sbjct: 620 SPVKEEAKSPAEVKSPEKAKSPTKEEAKSPEKAKSPEKEEAKSPEKAKSPVKAEAKSPEK 679
Query: 341 ----VKAESEPREAKKALEVEESNSEDEASFKSESAQSSPSNSSS---------SSDSSS 387
VKAE++ E K+ EE+ S ++A + SP + S S
Sbjct: 680 AKSPVKAEAKSPEKAKSPVKEEAKSPEKAKSPVKEEAKSPEKAKSPVKEEAKTPEKAKSP 739
Query: 388 DSDFEPSQNHSQGPLRSMVEDLQSEESDEDDSSSGEEAAGK-----TNPGRDSRLSFSDS 442
+ S ++ P ++ D++S E+ A K +P ++ S +
Sbjct: 740 VKEEAKSPEKAKSPEKAKTLDVKSPEAKTPAKEEARSPADKFPEKAKSPVKEEVKSPEKA 799
Query: 443 ESDNSADSSLPSREPPPPQKPPPPNSKVSGRRSPESCSKPEKILKKGTYDKA 494
+S D+ P +E P ++ P V P+ K ++ KK +KA
Sbjct: 800 KSPLKEDAKAPEKEIPKKEEVKSP---VKEEEKPQEV-KVKEPPKKAEEEKA 847
Score = 72.4 bits (176), Expect = 1e-12
Identities = 67/283 (23%), Positives = 113/283 (39%), Gaps = 40/283 (14%)
Query: 172 PKKTKPSHGSKDANKESSKTSKPHKVTKEHRERPRKDSESKSSSKELER----EQAKSSK 227
P+K K +K + +S + P KE P K+ S E E+AKS
Sbjct: 747 PEKAKSPEKAKTLDVKSPEAKTP---AKEEARSPADKFPEKAKSPVKEEVKSPEKAKSPL 803
Query: 228 DTSRKLGEGRLPKEE--KAP--------------PPKAAFKEPKMALKETKLESTSPKGG 271
K E +PK+E K+P PPK A +E A +T+ + S K
Sbjct: 804 KEDAKAPEKEIPKKEEVKSPVKEEEKPQEVKVKEPPKKAEEEKAPATPKTEEKKDSKKEE 863
Query: 272 PPPPPPPPPRASSKRPATADSPKPSAKKQKKSSSKGSRSAPGTSPRTSSSSSFSDKKPAK 331
P P P+ K+ + PK S + KK ++ + P +P + + K+ AK
Sbjct: 864 APKKEAPKPKVEEKKEPAVEKPKESKVEAKKEEAEDKKKVP--TPEKEAPAKVEVKEDAK 921
Query: 332 DKSSTR-------GEKVKAESEPREAKKALEVEESNSEDEASFKSESAQSSPSNSSSSSD 384
K T K K S+P E K+A ++ E+ K++ + P + + +
Sbjct: 922 PKEKTEVAKKEPDDAKAKEPSKPAEKKEAAPEKKDTKEE----KAKKPEEKPKTEAKAKE 977
Query: 385 SSSDSDFEPSQNHSQGPLRSMVEDLQS----EESDEDDSSSGE 423
EPS+ ++ +S D + E++ ED ++ G+
Sbjct: 978 DDKTLSKEPSKPKAEKAEKSSSTDQKDSKPPEKATEDKAAKGK 1020
Score = 70.9 bits (172), Expect = 3e-12
Identities = 77/335 (22%), Positives = 139/335 (41%), Gaps = 27/335 (8%)
Query: 173 KKTKPSHGSKDANKESSKTSKPHKVTKEH--RERPRKDSESKSSSKELEREQAKSSKDTS 230
++T+ + +++ +E K +K + +E E + E ++ S E + + S
Sbjct: 459 EQTEETQVTEEVTEEEEKEAKEEEGKEEEGGEEEEAEGGEEETKSPPAEEAASPEKEAKS 518
Query: 231 RKLGEGRLPKEEKAPPPK-----AAFKEPKMALKETKLESTSPKGGPPPPPPPPPRASSK 285
E + P E K+P + A K P+ A K E+ S PP P + +K
Sbjct: 519 PVKEEAKSPAEAKSPEKEEAKSPAEVKSPEKAKSPAKEEAKS-----PPEAKSPEKEEAK 573
Query: 286 RPATADSP---KPSAKKQKKSSSKGSRSAPGTSP-RTSSSSSFSDKKPAKDKSSTRGE-- 339
PA SP K AK++ KS ++ SP + + S K P K+++ + E
Sbjct: 574 SPAEVKSPEKAKSPAKEEAKSPAEAKSPEKAKSPVKEEAKSPAEAKSPVKEEAKSPAEVK 633
Query: 340 -KVKAESEPREAKKALEVEESNSEDEASFKSESAQSSPSNSSSSSDSSSDSDFEPSQNHS 398
KA+S +E K+ E +S ++EA KS SP + + S + S P + +
Sbjct: 634 SPEKAKSPTKEEAKSPEKAKSPEKEEA--KSPEKAKSPVKAEAKSPEKAKS---PVKAEA 688
Query: 399 QGPLRSMVEDLQSEESDEDDSSSGEEAAGKTNPGRDSRLSFSDSESDNSADSSLPSREPP 458
+ P ++ + +S E S +E A +P + ++++ A S +
Sbjct: 689 KSPEKAKSPVKEEAKSPEKAKSPVKEEA--KSPEKAKSPVKEEAKTPEKAKSPVKEEAKS 746
Query: 459 PPQKPPPPNSKVSGRRSPESCSKPEKILKKGTYDK 493
P + P +K +SPE+ P K + DK
Sbjct: 747 PEKAKSPEKAKTLDVKSPEA-KTPAKEEARSPADK 780
Score = 70.9 bits (172), Expect = 3e-12
Identities = 76/339 (22%), Positives = 131/339 (38%), Gaps = 31/339 (9%)
Query: 173 KKTKPSHGSKDANKESSKTSKPHKVTKEHRERPRKDSESKSSSKELEREQAKS------- 225
++ K +K KE +K+ K ++ + +++++S +K E+E+AKS
Sbjct: 522 EEAKSPAEAKSPEKEEAKSPAEVKSPEKAKSPAKEEAKSPPEAKSPEKEEAKSPAEVKSP 581
Query: 226 SKDTSRKLGEGRLPKEEKAP-----PPKAAFKEPKMALKETKLESTSP-KGGPPPPPPPP 279
K S E + P E K+P P K K P A K E+ SP + P P
Sbjct: 582 EKAKSPAKEEAKSPAEAKSPEKAKSPVKEEAKSPAEAKSPVKEEAKSPAEVKSPEKAKSP 641
Query: 280 PRASSKRPATADSPKPSAKKQKKSSSKGSRSAPGTSPRTSSSSSFSDKKPAKDKSSTRGE 339
+ +K P A SP+ K + + ++ + + S K P K KS + E
Sbjct: 642 TKEEAKSPEKAKSPEKEEAKSPEKAKSPVKAEAKSPEKAKSPVKAEAKSPEKAKSPVKEE 701
Query: 340 ---------KVKAESEPREAKKALEVEESNSEDEASFKSESAQSSPSNSSS-----SSDS 385
VK E++ E K+ EE+ + ++A + SP + S + D
Sbjct: 702 AKSPEKAKSPVKEEAKSPEKAKSPVKEEAKTPEKAKSPVKEEAKSPEKAKSPEKAKTLDV 761
Query: 386 SSDSDFEPSQNHSQGPLRSMVEDLQSEESDEDDSSSGEEAAGKTNPGRDSRLSFSDSESD 445
S P++ ++ P E +S +E S E+A K+ D++ +
Sbjct: 762 KSPEAKTPAKEEARSPADKFPEKAKSPVKEE--VKSPEKA--KSPLKEDAKAPEKEIPKK 817
Query: 446 NSADSSLPSREPPPPQKPPPPNSKVSGRRSPESCSKPEK 484
S + E P K P K ++P + EK
Sbjct: 818 EEVKSPVKEEEKPQEVKVKEPPKKAEEEKAPATPKTEEK 856
Score = 69.3 bits (168), Expect = 9e-12
Identities = 95/409 (23%), Positives = 153/409 (37%), Gaps = 59/409 (14%)
Query: 145 PEGADTVSRPSPDYPMLPTIPLSAFSDPKKTKPSHG-SKDANKESSKTSKPHKVTKEHRE 203
PE A + ++ P P A S K+ S +K KE +K+ K ++ +
Sbjct: 581 PEKAKSPAKEEAKSPAEAKSPEKAKSPVKEEAKSPAEAKSPVKEEAKSPAEVKSPEKAKS 640
Query: 204 RPRKDSESKSSSKELEREQAKS-SKDTSRKLGEGRLPKEEKAPPP-KAAFKEPKMALKET 261
+++++S +K E+E+AKS K S E + P EKA P KA K P+ A
Sbjct: 641 PTKEEAKSPEKAKSPEKEEAKSPEKAKSPVKAEAKSP--EKAKSPVKAEAKSPEKAKSPV 698
Query: 262 KLESTSP---------KGGPPPPPPPPPRASSKRPATADSP-------KPSAKKQKKSSS 305
K E+ SP + P P + +K P A SP AK +K+ +
Sbjct: 699 KEEAKSPEKAKSPVKEEAKSPEKAKSPVKEEAKTPEKAKSPVKEEAKSPEKAKSPEKAKT 758
Query: 306 KGSRSAPGTSPRTSSSSSFSDKKPAKDKSSTRGE-----------KVKAESEPREAKKAL 354
+S +P + S +DK P K KS + E K A++ +E K
Sbjct: 759 LDVKSPEAKTPAKEEARSPADKFPEKAKSPVKEEVKSPEKAKSPLKEDAKAPEKEIPKKE 818
Query: 355 EVEESNSEDE--------------------ASFKSESAQSSPSNSSSSSDSSSDSDFEPS 394
EV+ E+E A+ K+E + S + ++ E
Sbjct: 819 EVKSPVKEEEKPQEVKVKEPPKKAEEEKAPATPKTEEKKDSKKEEAPKKEAPKPKVEEKK 878
Query: 395 QNHSQGPLRSMVEDLQSEESDEDDSSSGE-EAAGKTNPGRDSRLSFSDSESDNSADSSLP 453
+ + P S VE + E D+ + E EA K D++ + D +
Sbjct: 879 EPAVEKPKESKVEAKKEEAEDKKKVPTPEKEAPAKVEVKEDAKPKEKTEVAKKEPDDAKA 938
Query: 454 SREPPPPQK----PPPPNSKVSGRRSPESCSKPEKILKKGTYDKAYTDE 498
P +K P ++K + PE KP+ K DK + E
Sbjct: 939 KEPSKPAEKKEAAPEKKDTKEEKAKKPE--EKPKTEAKAKEDDKTLSKE 985
Score = 66.6 bits (161), Expect = 6e-11
Identities = 91/375 (24%), Positives = 148/375 (39%), Gaps = 51/375 (13%)
Query: 155 SPDYPMLPTIPLSAFSDPKKTKPSHGSKDANKESSKTSKPHKVTKEHRERPRKDSESKSS 214
SP P S + K+ P +K KE +K+ P +V + + E+KS
Sbjct: 540 SPAEVKSPEKAKSPAKEEAKSPPE--AKSPEKEEAKS--PAEVKSPEKAKSPAKEEAKSP 595
Query: 215 SKELEREQAKSS-KDTSRKLGEGRLPKEEKAPPPKAAFKEPKMALKETKLESTSPKGGPP 273
++ E+AKS K+ ++ E + P +E+A P A K P+ A TK E+ SP+
Sbjct: 596 AEAKSPEKAKSPVKEEAKSPAEAKSPVKEEAKSP-AEVKSPEKAKSPTKEEAKSPEKAKS 654
Query: 274 PPPPP---------PPRASSKRPATADSP-KPSAKKQKKSSSKGSRSAPGTSPRTS---- 319
P P +A +K P A SP K AK +K+ S A S
Sbjct: 655 PEKEEAKSPEKAKSPVKAEAKSPEKAKSPVKAEAKSPEKAKSPVKEEAKSPEKAKSPVKE 714
Query: 320 -SSSSFSDKKPAKDKSSTRGEKVKA--ESEPREAKKALEVEESNSED----EASFKSESA 372
+ S K P K+++ T EK K+ + E + +KA E++ + D EA ++
Sbjct: 715 EAKSPEKAKSPVKEEAKT-PEKAKSPVKEEAKSPEKAKSPEKAKTLDVKSPEAKTPAKEE 773
Query: 373 QSSPSNSSSSSDSSSDSDFEPSQNHSQGPLRSMVEDLQSE-------ESDEDDSSSGEEA 425
SP++ S + S ++ PL+ + + E +S + +E
Sbjct: 774 ARSPADKFPEKAKSPVKEEVKSPEKAKSPLKEDAKAPEKEIPKKEEVKSPVKEEEKPQEV 833
Query: 426 AGKTNPGR----DSRLSFSDSESDNSADSSLPSREPPPP----QKPP----PPNSKVSGR 473
K P + + + E +S P +E P P +K P P SKV +
Sbjct: 834 KVKEPPKKAEEEKAPATPKTEEKKDSKKEEAPKKEAPKPKVEEKKEPAVEKPKESKVEAK 893
Query: 474 RSPESCSK----PEK 484
+ K PEK
Sbjct: 894 KEEAEDKKKVPTPEK 908
Score = 60.1 bits (144), Expect = 5e-09
Identities = 71/331 (21%), Positives = 131/331 (39%), Gaps = 50/331 (15%)
Query: 161 LPTIPLSAFSDPKKTKPSHGSKDANKESSKTSKPHKVTKEHRERPRKDSESKSSSKELER 220
LP IP + S K K K K +T + T+E + E + +KE E
Sbjct: 426 LPKIP--SVSTHIKVKSEEKIKVVEKSEKETVIVEEQTEETQVTEEVTEEEEKEAKEEEG 483
Query: 221 EQAKSSKDTSRKLGEGRLPKEEKAPPPKAAFKEPKMALKETKLESTSPKGGPPPPPPPPP 280
++ + ++ + GE +E K+PP + A K A K E+ SP P
Sbjct: 484 KEEEGGEEEEAEGGE----EETKSPPAEEAASPEKEAKSPVKEEAKSPAEAKSPE----- 534
Query: 281 RASSKRPATADSPKPSAKKQKKSSSKGSRSAPGTSPRTSSSSSFSDKKPAKDKSSTRGEK 340
+ +K PA SP+ + K+ + K P + KS + E+
Sbjct: 535 KEEAKSPAEVKSPEKAKSPAKEEA----------------------KSPPEAKSPEK-EE 571
Query: 341 VKAESEPREAKKALEVEESNSEDEASFKSESAQSSPSNSSSSSDSSSDSDFEPSQNHSQG 400
K+ +E + +KA + ++ A KS SP + S + + S P + ++
Sbjct: 572 AKSPAEVKSPEKAKSPAKEEAKSPAEAKSPEKAKSPVKEEAKSPAEAKS---PVKEEAKS 628
Query: 401 PLRSMVEDLQSEESDEDDSSSGEEAAGKTNPGRDSRLSFSDSESDNSADSSLPSREPPP- 459
P + +++ ++++ S E+A +P ++ S ++S A++ P + P
Sbjct: 629 PAEVKSPE-KAKSPTKEEAKSPEKA---KSPEKEEAKSPEKAKSPVKAEAKSPEKAKSPV 684
Query: 460 ------PQKPPPPNSKVSGRRSPESCSKPEK 484
P+K P + + +SPE P K
Sbjct: 685 KAEAKSPEKAKSPVKEEA--KSPEKAKSPVK 713
Score = 35.8 bits (81), Expect = 0.11
Identities = 24/87 (27%), Positives = 41/87 (47%), Gaps = 9/87 (10%)
Query: 168 AFSDPKKTKPSHGSKDANKESSKTSKPHKVTKEHR-----ERPRKDSESKSSSKELEREQ 222
A +P K SK A K+ + K K TKE + E+P+ ++++K K L +E
Sbjct: 929 AKKEPDDAKAKEPSKPAEKKEAAPEK--KDTKEEKAKKPEEKPKTEAKAKEDDKTLSKEP 986
Query: 223 AKSSKDTSRKLGEGRLPKEEKAPPPKA 249
+K + + K +++ PP KA
Sbjct: 987 SKPKAEKAEK--SSSTDQKDSKPPEKA 1011
>gi|50962882 G patch domain containing 8 [Homo sapiens]
Length = 1502
Score = 74.3 bits (181), Expect = 3e-13
Identities = 88/345 (25%), Positives = 128/345 (37%), Gaps = 60/345 (17%)
Query: 167 SAFSDPKKTKPSHGSKDANKESSKTSKPHKVTKEHRERPRKDSESKSSSKELEREQAKSS 226
S D ++ PS + K K HK + +H+ + + D+E KSS E E++K
Sbjct: 653 SETEDTGRSLPSKKERSGKSHRHKKKKKHKKSSKHKRKHKADTEEKSSKAE-SGEKSKKR 711
Query: 227 KDTSRKLGEGRLPKE-EKAPPPKAAFKEPKMALKETKLESTSPKGGPPPPPPPPPRA--- 282
K RK + P + E+ P P EP P G P PP RA
Sbjct: 712 KKRKRKKNKSSAPADSERGPKP-----EP-------------PGSGSPAPPRRRRRAQDD 753
Query: 283 SSKRPATADSPKPSAKKQ----KKSSSKGSRSAPGTSP-----------RTSSSSSFSDK 327
S +R A+ K + S G R G P R+S SS S
Sbjct: 754 SQRRSLPAEEGSSGKKDEGGGGSSSQDHGGRKHKGELPPSSCQRRAGTKRSSRSSHRSQP 813
Query: 328 KPAKDKSSTRGEKVKAESEPREAKKALEVEESNSEDEAS-----FKSESAQSSPSNSSSS 382
+ S + P + + E E+S SE S + S +SS + SSS
Sbjct: 814 SSGDEDSDDASSHRLHQKSPSQYSEEEEEEDSGSEHSRSRSRSGRRHSSHRSSRRSYSSS 873
Query: 383 SDSSSDSDFEPSQ------NHSQGPLRSMVEDLQSEESDEDDSSSGEEAAGKTNPGRDSR 436
SD+SSD Q ++S RS +S +SD+ D +S + R R
Sbjct: 874 SDASSDQSCYSRQRSYSDDSYSDYSDRSRRHSKRSHDSDDSDYASSKH--------RSKR 925
Query: 437 LSFSDSESDNSADSSLPSREPPPPQKPPPPNSKVSGRRSPESCSK 481
+S S+ D S S+ + S+ GR SCS+
Sbjct: 926 HKYSSSDDDYSLSC---SQSRSRSRSHTRERSRSRGRSRSSSCSR 967
Score = 45.1 bits (105), Expect = 2e-04
Identities = 74/345 (21%), Positives = 117/345 (33%), Gaps = 55/345 (15%)
Query: 167 SAFSDPKK--TKPSHGSKDANKESSK-TSKPHKVTKEH------------------RERP 205
S +SD + +K SH S D++ SSK SK HK + RER
Sbjct: 895 SDYSDRSRRHSKRSHDSDDSDYASSKHRSKRHKYSSSDDDYSLSCSQSRSRSRSHTRERS 954
Query: 206 RKDSESKSSSKELEREQAKSSKDTSRKLGEGRLPKEEKAPPPKAAFKEPKMALKETKLES 265
R S+SSS R + +S T+ R +++ ++ + + ES
Sbjct: 955 RSRGRSRSSSCSRSRSKRRSRSTTAHSWQRSRSYSRDRSRSTRSPSQRSGSRKRSWGHES 1014
Query: 266 TSPKGGPPPPPPPPPRASSKRPATADSPKPSAKKQKKSSSKGSRSAPGTSPRTSSSSSFS 325
P R S +R S S +G PG S +
Sbjct: 1015 ------------PEERHSGRRDFIRSKIYRSQSPHYFRSGRG--EGPGKKDDGRGDDSKA 1060
Query: 326 DKKPAKDKSSTRGEKVKAESEPRE-----AKKALEVEESNSEDEASFKSESAQSSPSNSS 380
P+++ + G + + P + AK LE +S + SE Q++P+ +
Sbjct: 1061 TGPPSQNSNIGTGRGSEGDCSPEDKNSVTAKLLLEKIQSRKVERKPSVSEEVQATPNKAG 1120
Query: 381 SSSDSSSDSDFEPSQNHSQG--PLRSMVEDL-----QSEESDEDDSSSGEE-AAGKTNPG 432
F P S G P+ ++ L +++ +E GEE +T G
Sbjct: 1121 PKLKDPPQGYFGPKLPPSLGNKPVLPLIGKLPATRKPNKKCEESGLERGEEQEQSETEEG 1180
Query: 433 RDSRLSFSDSESDNSADSSLPSREPPPPQKPPPPNSKVSGRRSPE 477
SD PS E P PPP SG + +
Sbjct: 1181 -------PPGSSDALFGHQFPSEETTGPLLDPPPEESKSGEATAD 1218
Score = 42.7 bits (99), Expect = 9e-04
Identities = 70/330 (21%), Positives = 122/330 (36%), Gaps = 31/330 (9%)
Query: 172 PKKTKPSHGSKDANKESSKTSKPHKVTKEHRERPRKDSESKSSSKELEREQAKSSKDTSR 231
PK+T + S+ +K +K + V+ + E S S+ S E + ++ SSK+TS
Sbjct: 465 PKETSMTEPSEPGSKAEAKKALGGDVSDQSLE-----SHSQKVS-ETQMCESNSSKETSL 518
Query: 232 KLGEGRLPKEEKAPPPKAAFKEPKMALKETKLESTSPKGGPPPPPPPPPRASSKRPATAD 291
G+ +E P F P ++ K EST+ + P + P+ +
Sbjct: 519 ATPAGKESQEGPKHPTGPFF--PVLS----KDESTALQW-----PSELLIFTKAEPSISY 567
Query: 292 SPKPSAKKQKKSSSKGSRSAPGTSPRTSSSSSFSDKKPAKDKSSTRGEKVKAESEPREAK 351
S P K S +K +R+ P+ SSS + + ++V E R +
Sbjct: 568 SCNPLYFDFKLSRNKDARTKGTEKPKDIGSSSKDHLQGLDPGEPNKSKEVGGEKIVRSSG 627
Query: 352 KALEVEESNS--------EDEASFKSESAQSSPSNSSSSSDSSSDSDFEPSQNHSQGPLR 403
++ S S E S SE+ + S S S + + H +
Sbjct: 628 GRMDAPASGSACSGLNKQEPGGSHGSETEDTGRSLPSKKERSGKSHRHKKKKKHKKSSKH 687
Query: 404 SMVEDLQSEESDEDDSSSGEEAAGKTNPGRDSRLSFSDSESDNSADSSLPSREPPPPQKP 463
+EE + SGE++ + R S + ++S+ P EPP P
Sbjct: 688 KRKHKADTEEKSSK-AESGEKSKKRKKRKRKKNKSSAPADSERG-----PKPEPPGSGSP 741
Query: 464 PPPNSKVSGRRSPESCSKPEKILKKGTYDK 493
PP + + + S P + G D+
Sbjct: 742 APPRRRRRAQDDSQRRSLPAEEGSSGKKDE 771
Score = 40.0 bits (92), Expect = 0.006
Identities = 75/342 (21%), Positives = 114/342 (33%), Gaps = 56/342 (16%)
Query: 178 SHGSKDANKESSKTSKPHKVTKEHRERP----RKDSESKSSSKELEREQAKSSKDTSRKL 233
S G KD S +S+ H K E P ++ + +K SS+ R Q S + S
Sbjct: 765 SSGKKDEGGGGS-SSQDHGGRKHKGELPPSSCQRRAGTKRSSRSSHRSQPSSGDEDSDDA 823
Query: 234 GEGRLPKEEKAPPPKAAFKEPKMALKETKLESTSPKGGPPPPPPPPPRASSKRPATADSP 293
RL + K P +E + E + + R+ S+ S
Sbjct: 824 SSHRLHQ-----------KSPSQYSEEEEEEDSGSEHS---------RSRSRSGRRHSSH 863
Query: 294 KPSAKKQKKSSSKGSRSAPGTSPRTSSSSSFSDKKPAKDKSSTRG----EKVKAESEPRE 349
+ S + SS S + + R+ S S+SD + S R + A S+ R
Sbjct: 864 RSSRRSYSSSSDASSDQSCYSRQRSYSDDSYSDYSDRSRRHSKRSHDSDDSDYASSKHRS 923
Query: 350 AKK---------ALEVEESNSEDEASFKSESAQSSPSNSSSSSDSSSDSDFEPSQNHSQG 400
+ +L +S S + + S S SSS S S S + HS
Sbjct: 924 KRHKYSSSDDDYSLSCSQSRSRSRSHTRERSRSRGRSRSSSCSRSRSKRRSRSTTAHSWQ 983
Query: 401 PLRSMVEDLQ------SEESDEDDSSSGEEAAGKTNPGR-----------DSRLSFSDSE 443
RS D S+ S S G E+ + + GR S F
Sbjct: 984 RSRSYSRDRSRSTRSPSQRSGSRKRSWGHESPEERHSGRRDFIRSKIYRSQSPHYFRSGR 1043
Query: 444 SDNSADSSLPSREPPPPQKPPPPNSKV-SGRRSPESCSKPEK 484
+ + PP NS + +GR S CS +K
Sbjct: 1044 GEGPGKKDDGRGDDSKATGPPSQNSNIGTGRGSEGDCSPEDK 1085
Score = 29.3 bits (64), Expect = 10.0
Identities = 68/314 (21%), Positives = 100/314 (31%), Gaps = 43/314 (13%)
Query: 184 ANKESSKTSKPHKVTKEHRERPRKDSESKSSSKELEREQAKSSKDTSRKLGEGRLPKEEK 243
A+K+ K K + + R RKD + + + E A+ K + E
Sbjct: 161 AHKQRLKDLKQREFARNVSSRSRKDEKKQEKALRRLHELAEQRK------------QAEC 208
Query: 244 APPPKAAFKEPKMALKETKLESTSPKGGPPPPPPPPPRASSKRPATADSPKPSAKKQKKS 303
AP FK +A+ E E + + D P Q +
Sbjct: 209 APGSGPMFKPTTVAVDEEGGEDDKDESATNSGTGATASCGLGSEFSTDKGGPFTAVQ-IT 267
Query: 304 SSKGSRSAPGTSPRTSSSSSFSDK--------KPAKDKSSTRGEKVKAESEPREAKKALE 355
++ G APG + S SF K K S + VK ES K
Sbjct: 268 NTTGLAQAPGLA---SQGISFGIKNNLGTPLQKLGVSFSFAKKAPVKLESIASVFKD--H 322
Query: 356 VEESNSEDEASFKSESAQSSPSNSSSSSDSSS-DSDFEPSQNHSQGPLRSMVEDLQSEES 414
EE SED +S+ S SS+ D E G L S + L+ +
Sbjct: 323 AEEGTSEDGTKPDEKSSDQGLQKVGDSDGSSNLDGKKEDEDPQDGGSLASTLSKLKRMKR 382
Query: 415 DEDDSSSGEE-------AAGKTNPGRDSRLSFSDSESDNSADSSLPSREPPPPQKPPPPN 467
+E ++ E A K P L SE + +++ P P
Sbjct: 383 EEGAGATEPEYYHYIPPAHCKVKPNFPFLLFMRASEQMDGDNTTHPKN---------APE 433
Query: 468 SKVSGRRSPESCSK 481
SK P+SC K
Sbjct: 434 SKKGSSPKPKSCIK 447
>gi|16332372 cell division cycle 2-like 1 (PITSLRE proteins) isoform
9 [Homo sapiens]
Length = 771
Score = 72.0 bits (175), Expect = 1e-12
Identities = 83/343 (24%), Positives = 137/343 (39%), Gaps = 24/343 (6%)
Query: 173 KKTKPSHGSKDANKESSKTSKPHKVTKEHRERPRKDSESKSSSKELEREQAKSSKDTSRK 232
++ K +D + + K ++ +EH R R E +E ER+ + K+ R+
Sbjct: 121 ERRKRHREEQDKARREWERQKRREMAREHSRRERDRLEQLERKRERERKMREQQKE-QRE 179
Query: 233 LGEGRLPKEEKAPPPKAAFKEPKMALKETKLESTSPKGGPPPPPPPPPRASSKRPATADS 292
E EE+ +A + A T E S K PPR +R D
Sbjct: 180 QKERERRAEERRKEREA--RREVSAHHRTMREDYSDKVKASHWSRSPPRPPRERFELGDG 237
Query: 293 PKP--SAKKQKKSSSKGSRSAPGTSPRTSSSSSFSDKKPAKDKSSTRGEKVKAESEPREA 350
KP K +++ + + +TSS+ S S A+ S + E+ + E E E
Sbjct: 238 RKPVKEEKMEERDLLSDLQDISDSERKTSSAESSS----AESGSGSEEEEEEEEEEEEEG 293
Query: 351 KKALEVEESNSEDEASFKSESAQSSPSNSSSSSDSSSDSDFEPSQNHSQGPLRSMVEDLQ 410
+ E EE E+E + + S ++ S+ + S + E + ++ L + E
Sbjct: 294 STSEESEEEEEEEEEEEEETGSNSEEASEQSAEEVSEEEMSEDEERENENHLLVVPESRF 353
Query: 411 SEESDEDDSSSGEEAAGKTNPGRDSRLSFSDSESDNSADSSLPSREPPPPQKPPPPNSKV 470
+S E S EE G+ P + S L+ D D+ A S + ++ P P +
Sbjct: 354 DRDSGE--SEEAEEEVGEGTP-QSSALTEGDYVPDSPALSPIELKQELPKYLP-----AL 405
Query: 471 SGRRSPESCSKPEKILKKGTYDKAY------TDELVELHRRLM 507
G RS E +I ++GTY Y TDE+V L R M
Sbjct: 406 QGCRSVEEFQCLNRI-EEGTYGVVYRAKDKKTDEIVALKRLKM 447
>gi|16332362 cell division cycle 2-like 1 (PITSLRE proteins) isoform
4 [Homo sapiens]
Length = 737
Score = 72.0 bits (175), Expect = 1e-12
Identities = 83/343 (24%), Positives = 137/343 (39%), Gaps = 24/343 (6%)
Query: 173 KKTKPSHGSKDANKESSKTSKPHKVTKEHRERPRKDSESKSSSKELEREQAKSSKDTSRK 232
++ K +D + + K ++ +EH R R E +E ER+ + K+ R+
Sbjct: 87 ERRKRHREEQDKARREWERQKRREMAREHSRRERDRLEQLERKRERERKMREQQKE-QRE 145
Query: 233 LGEGRLPKEEKAPPPKAAFKEPKMALKETKLESTSPKGGPPPPPPPPPRASSKRPATADS 292
E EE+ +A + A T E S K PPR +R D
Sbjct: 146 QKERERRAEERRKEREA--RREVSAHHRTMREDYSDKVKASHWSRSPPRPPRERFELGDG 203
Query: 293 PKP--SAKKQKKSSSKGSRSAPGTSPRTSSSSSFSDKKPAKDKSSTRGEKVKAESEPREA 350
KP K +++ + + +TSS+ S S A+ S + E+ + E E E
Sbjct: 204 RKPVKEEKMEERDLLSDLQDISDSERKTSSAESSS----AESGSGSEEEEEEEEEEEEEG 259
Query: 351 KKALEVEESNSEDEASFKSESAQSSPSNSSSSSDSSSDSDFEPSQNHSQGPLRSMVEDLQ 410
+ E EE E+E + + S ++ S+ + S + E + ++ L + E
Sbjct: 260 STSEESEEEEEEEEEEEEETGSNSEEASEQSAEEVSEEEMSEDEERENENHLLVVPESRF 319
Query: 411 SEESDEDDSSSGEEAAGKTNPGRDSRLSFSDSESDNSADSSLPSREPPPPQKPPPPNSKV 470
+S E S EE G+ P + S L+ D D+ A S + ++ P P +
Sbjct: 320 DRDSGE--SEEAEEEVGEGTP-QSSALTEGDYVPDSPALSPIELKQELPKYLP-----AL 371
Query: 471 SGRRSPESCSKPEKILKKGTYDKAY------TDELVELHRRLM 507
G RS E +I ++GTY Y TDE+V L R M
Sbjct: 372 QGCRSVEEFQCLNRI-EEGTYGVVYRAKDKKTDEIVALKRLKM 413
>gi|42542379 serine/arginine repetitive matrix 1 [Homo sapiens]
Length = 904
Score = 72.0 bits (175), Expect = 1e-12
Identities = 85/361 (23%), Positives = 133/361 (36%), Gaps = 43/361 (11%)
Query: 148 ADTVSRPSPDYPMLPTIPLSAFSDPKKTKPSHGSKDANKESSKTSKPHKVTKEHRERPRK 207
+D + P P+ P P S + KK K ++ ++ SK+ + RPR+
Sbjct: 242 SDILKVPKPEPIPEPKEP-SPEKNSKKEKEKEKTRPRSRSRSKSRSRTRSRSPSHTRPRR 300
Query: 208 DSESKSSSKELEREQAKSSKDTSRKLGEGRLPKEEKAPPPK--------AAFKEPKMALK 259
S+S S R + + + R+ R P PPP+ + +L
Sbjct: 301 RHRSRSRSYSPRRRPSPRRRPSPRR----RTPPRRMPPPPRHRRSRSPVRRRRRSSASLS 356
Query: 260 ETKLESTSPKGGPPPPPPPPPRASSKRPATADSPKPSAKKQKKSSSKGSRSAPGT--SPR 317
+ S+S + PP PP +S R SP S +++ S + P T SP
Sbjct: 357 GSSSSSSSSRSRSPPKKPPKRTSSPPRKTRRLSPSASPPRRRHRPSPPATPPPKTRHSPT 416
Query: 318 TSSSSSFSDKKPAKDKSSTRGEKVK-----AESEPREAKKALEVEESNSEDEASFKSESA 372
S+ + + T G+ K P A K +VE S SE++ K +A
Sbjct: 417 PQQSNRTRKSRVSVSPGRTSGKVTKHKGTEKRESPSPAPKPRKVELSESEEDKGGKMAAA 476
Query: 373 QS----------SPSNSSSSSDSSSDSDFEPSQNHSQGPLRSMVEDLQSEESDEDDSSSG 422
S + +SS S SSS D P ++H + V + S S
Sbjct: 477 DSVQQRRQYRRQNQQSSSDSGSSSSSEDERPKRSHVK---NGEVGRRRRHSPSRSASPSP 533
Query: 423 EEAAGKTNPGRDSRLSFSDSESDNSADSSLPSREPPPPQK---PPPPNSKVSG----RRS 475
+ +T+P R S S + PS PPP ++ PPP + RRS
Sbjct: 534 RKRQKETSPRGRRRRSPSPPPTRRRRS---PSPAPPPRRRRTPTPPPRRRTPSPPPRRRS 590
Query: 476 P 476
P
Sbjct: 591 P 591
Score = 71.6 bits (174), Expect = 2e-12
Identities = 80/321 (24%), Positives = 120/321 (37%), Gaps = 48/321 (14%)
Query: 171 DPKKTKPSHGSKDANKESSKTSKPHKVTKEHRERPRKDSESKSSSKELEREQAKSSKDTS 230
D K K K++++E + S+ + K PR+ S +E +R ++S + +
Sbjct: 148 DEDKDKRDKEEKESSREKRERSRSPRRRKSRSPSPRR--RSSPVRRERKRSHSRSPRHRT 205
Query: 231 RKLGEGRLP-KEEKAPPPKAAFKEPKMALKETKLE---STS-----PKGGP-PPPPPPPP 280
+ P K+EK P EP + +KE ++ STS PK P P P P P
Sbjct: 206 KSRSPSPAPEKKEKTPE----LPEPSVKVKEPSVQEATSTSDILKVPKPEPIPEPKEPSP 261
Query: 281 RASSKRPATADSPKPSAKKQKKSSSKG-SRSAPGTSPRTSSSSSFSDKKPAKDKSSTRGE 339
+SK+ + +P ++ + KS S+ SRS T PR S P + S R
Sbjct: 262 EKNSKKEKEKEKTRPRSRSRSKSRSRTRSRSPSHTRPRRRHRSRSRSYSPRRRPSPRRRP 321
Query: 340 KVKAESEPREAKKALEVEESNSEDEASFKSESAQSSPSNSSSSSDSSSDSDFEPSQNHSQ 399
+ + PR S S +S ++ S S+SSSSS S S P + S
Sbjct: 322 SPRRRTPPRRMPPPPRHRRSRSPVRRRRRSSASLSGSSSSSSSSRSRSPPKKPPKRTSSP 381
Query: 400 GPLRSMVEDLQSEESDEDDSSSGEEAAGKTNPGRDSRLSFSDSESDNSADSSLPSREPPP 459
P + RLS S S S P+ PP
Sbjct: 382 -------------------------------PRKTRRLSPSASPPRRRHRPSPPATPPPK 410
Query: 460 PQKPPPPNSKVSGRRSPESCS 480
+ P P R+S S S
Sbjct: 411 TRHSPTPQQSNRTRKSRVSVS 431
Score = 63.9 bits (154), Expect = 4e-10
Identities = 87/407 (21%), Positives = 142/407 (34%), Gaps = 63/407 (15%)
Query: 137 RAGGVMVMPEGADTVSRPSPDYPMLPTIPLSAFSDPKKTKPSHGSKDANKESSKTSKPHK 196
R G + +G + PSP P+K + S +D + + +
Sbjct: 434 RTSGKVTKHKGTEKRESPSPA------------PKPRKVELSESEEDKGGKMAAADSVQQ 481
Query: 197 VTKEHRERPRKDSESKSSSKELEREQAKSSKDTSRKLGEGRL--PKEEKAPPPKAAFKEP 254
+ R+ + S+S SSS E E+ K S + ++G R P +P P+ KE
Sbjct: 482 RRQYRRQNQQSSSDSGSSSSS-EDERPKRSHVKNGEVGRRRRHSPSRSASPSPRKRQKET 540
Query: 255 KMALKETKLEST-------SPKGGPPP-------PPP------PPPRASSKRPATADSP- 293
+ + S SP PPP PPP PPPR S P P
Sbjct: 541 SPRGRRRRSPSPPPTRRRRSPSPAPPPRRRRTPTPPPRRRTPSPPPRRRSPSPRRYSPPI 600
Query: 294 ----KPSAKKQKKSSSKGS----RSAPGTSPRTSSSSSFSDKKPA----KDKSSTRGEKV 341
PS +++++S R++P P+ S S K+ + K +S + K
Sbjct: 601 QRRYSPSPPPKRRTASPPPPPKRRASPSPPPKRRVSHSPPPKQRSSPVTKRRSPSLSSKH 660
Query: 342 KAESEPREAKKALEVEESNSEDEASFKSESAQSSPSNSSSSSDSSSDSDFEPSQNHSQGP 401
+ S P + + + N S + + Q+S S +SS S + S P
Sbjct: 661 RKGSSPSRSTREARSPQPNKRHSPSPRPRAPQTSSSPPPVRRGASSSPQRRQSPSPSTRP 720
Query: 402 LRSMVEDLQSEE---------------SDEDDSSSGEEAAGKTNPGRDSRLSFSDSESDN 446
+R + + ++ S S E A K P S + ++
Sbjct: 721 IRRVSRTPEPKKIKKAASPSPQSVRRVSSSRSVSGSPEPAAKKPPAPPSPVQSQSPSTNW 780
Query: 447 SADSSLPSREPPPPQKPPPPNSKVSGRRSPESCSKPEKILKKGTYDK 493
S + + P P PP NS G + K +K K + K
Sbjct: 781 SPAVPVKKAKSPTPSPSPPRNSDQEGGGKKKKKKKDKKHKKDKKHKK 827
Score = 55.5 bits (132), Expect = 1e-07
Identities = 68/278 (24%), Positives = 104/278 (37%), Gaps = 19/278 (6%)
Query: 154 PSPDYPMLPTIPLSAFSDP--KKTKPSHGSK----DANKESSKTSKPHKVTKEHRERPRK 207
P P + + P S P K+ PS SK + S++ ++ + K H PR
Sbjct: 629 PPPKRRVSHSPPPKQRSSPVTKRRSPSLSSKHRKGSSPSRSTREARSPQPNKRHSPSPRP 688
Query: 208 DSESKSSSKELEREQAKSSKDTSRKLGEGRLP--KEEKAPPPK----AAFKEPKMALKET 261
+ SSS R A SS + P + + P PK AA P+ + +
Sbjct: 689 RAPQTSSSPPPVRRGASSSPQRRQSPSPSTRPIRRVSRTPEPKKIKKAASPSPQSVRRVS 748
Query: 262 KLESTSPKGGPPPPPPPPPRA--SSKRPATADSPKPSAKKQKKSSSKGSRSAPGTSPRT- 318
S S P PP P + S+ P+T SP KK K S S S P S +
Sbjct: 749 SSRSVSGSPEPAAKKPPAPPSPVQSQSPSTNWSPAVPVKKAK--SPTPSPSPPRNSDQEG 806
Query: 319 --SSSSSFSDKKPAKDKSSTRGEKVKAESEPREAKKALEVEESNSEDEASFKSESAQSSP 376
DKK KDK + +K K E A A + + + E ++P
Sbjct: 807 GGKKKKKKKDKKHKKDKKHKKHKKHKKEKAVAAAAAAAVTPAAIAAATTTLAQEEPVAAP 866
Query: 377 SNSSSSSDSSSDSDFEPSQNHSQGPLRSMVEDLQSEES 414
+ + D+ + ++ + LRSM + S +S
Sbjct: 867 EPKKETESEAEDNLDDLEKHLREKALRSMRKAQVSPQS 904
>gi|16332364 cell division cycle 2-like 1 (PITSLRE proteins) isoform
5 [Homo sapiens]
Length = 748
Score = 71.6 bits (174), Expect = 2e-12
Identities = 89/371 (23%), Positives = 144/371 (38%), Gaps = 49/371 (13%)
Query: 171 DPKKTKPSHGSKDANKESSKTSKPHKVTKEHRERPRKDSESKSSSKELER---------- 220
+ +K K H S A E K ++ + +EH R R E + +E ER
Sbjct: 69 EKRKEKRRHRSHSA--EGGKHARVKEKEREHERRKRHREEQDKARREWERQKRREMAREH 126
Query: 221 --------EQAKSSKDTSRKLGEGRLPKEEKAPPPKAAFKEPK--------MALKETKLE 264
EQ + ++ RK+ E + + E+ + A + K A T E
Sbjct: 127 SRRERDRLEQLERKRERERKMREQQKEQREQKERERRAEERRKEREARREVSAHHRTMRE 186
Query: 265 STSPKGGPPPPPPPPPRASSKRPATADSPKP--SAKKQKKSSSKGSRSAPGTSPRTSSSS 322
S K PPR +R D KP K +++ + + +TSS+
Sbjct: 187 DYSDKVKASHWSRSPPRPPRERFELGDGRKPVKEEKMEERDLLSDLQDISDSERKTSSAE 246
Query: 323 SFSDKKPAKDKSSTRGEKVKAESEPREAKKALEVEESNSEDEASFKSESAQSSPSNSSSS 382
S S A+ S + E+ + E E E + E EE E+E + + S ++ S+
Sbjct: 247 SSS----AESGSGSEEEEEEEEEEEEEGSTSEESEEEEEEEEEEEEETGSNSEEASEQSA 302
Query: 383 SDSSSDSDFEPSQNHSQGPLRSMVEDLQSEESDEDDSSSGEEAAGKTNPGRDSRLSFSDS 442
+ S + E + ++ L + E +S E S EE G+ P + S L+ D
Sbjct: 303 EEVSEEEMSEDEERENENHLLVVPESRFDRDSGE--SEEAEEEVGEGTP-QSSALTEGDY 359
Query: 443 ESDNSADSSLPSREPPPPQKPPPPNSKVSGRRSPESCSKPEKILKKGTYDKAY------T 496
D+ A S + ++ P P + G RS E +I ++GTY Y T
Sbjct: 360 VPDSPALSPIELKQELPKYLP-----ALQGCRSVEEFQCLNRI-EEGTYGVVYRAKDKKT 413
Query: 497 DELVELHRRLM 507
DE+V L R M
Sbjct: 414 DEIVALKRLKM 424
>gi|16332358 cell division cycle 2-like 1 (PITSLRE proteins) isoform
2 [Homo sapiens]
Length = 782
Score = 71.6 bits (174), Expect = 2e-12
Identities = 89/371 (23%), Positives = 144/371 (38%), Gaps = 49/371 (13%)
Query: 171 DPKKTKPSHGSKDANKESSKTSKPHKVTKEHRERPRKDSESKSSSKELER---------- 220
+ +K K H S A E K ++ + +EH R R E + +E ER
Sbjct: 103 EKRKEKRRHRSHSA--EGGKHARVKEKEREHERRKRHREEQDKARREWERQKRREMAREH 160
Query: 221 --------EQAKSSKDTSRKLGEGRLPKEEKAPPPKAAFKEPK--------MALKETKLE 264
EQ + ++ RK+ E + + E+ + A + K A T E
Sbjct: 161 SRRERDRLEQLERKRERERKMREQQKEQREQKERERRAEERRKEREARREVSAHHRTMRE 220
Query: 265 STSPKGGPPPPPPPPPRASSKRPATADSPKP--SAKKQKKSSSKGSRSAPGTSPRTSSSS 322
S K PPR +R D KP K +++ + + +TSS+
Sbjct: 221 DYSDKVKASHWSRSPPRPPRERFELGDGRKPVKEEKMEERDLLSDLQDISDSERKTSSAE 280
Query: 323 SFSDKKPAKDKSSTRGEKVKAESEPREAKKALEVEESNSEDEASFKSESAQSSPSNSSSS 382
S S A+ S + E+ + E E E + E EE E+E + + S ++ S+
Sbjct: 281 SSS----AESGSGSEEEEEEEEEEEEEGSTSEESEEEEEEEEEEEEETGSNSEEASEQSA 336
Query: 383 SDSSSDSDFEPSQNHSQGPLRSMVEDLQSEESDEDDSSSGEEAAGKTNPGRDSRLSFSDS 442
+ S + E + ++ L + E +S E S EE G+ P + S L+ D
Sbjct: 337 EEVSEEEMSEDEERENENHLLVVPESRFDRDSGE--SEEAEEEVGEGTP-QSSALTEGDY 393
Query: 443 ESDNSADSSLPSREPPPPQKPPPPNSKVSGRRSPESCSKPEKILKKGTYDKAY------T 496
D+ A S + ++ P P + G RS E +I ++GTY Y T
Sbjct: 394 VPDSPALSPIELKQELPKYLP-----ALQGCRSVEEFQCLNRI-EEGTYGVVYRAKDKKT 447
Query: 497 DELVELHRRLM 507
DE+V L R M
Sbjct: 448 DEIVALKRLKM 458
>gi|117935038 cylicin, basic protein of sperm head cytoskeleton 1
[Homo sapiens]
Length = 651
Score = 71.2 bits (173), Expect = 2e-12
Identities = 69/317 (21%), Positives = 121/317 (38%), Gaps = 47/317 (14%)
Query: 171 DPKKTKPSHGSKDANKESSKTSKPHKVTKEHRERPRKDSESKSSSK-----ELEREQAKS 225
D KK ++ + ES + K TK+ +++ +KD + K + K + E AK
Sbjct: 320 DDKKKDVKKDTESTDAESGDSKDERKDTKKDKKKLKKDDKKKDTKKYPESTDTESGDAKD 379
Query: 226 SKDTSRKLGEGRLPKEEKAPPPKAAFK---EPKMALKETKLESTSPKGGPPPPPPPPPRA 282
+++ SR L + ++K K F E ++ KE++ + K +
Sbjct: 380 ARNDSRNLKKASKNDDKKKDAKKITFSTDSESELESKESQKDEKKDKKDSKTDNKKSVKN 439
Query: 283 SSKRPATADSPKPSAKKQKKSSSKGSRSAPGTSPRTSSSSSFSDKKPAKDKSSTRGEKVK 342
+ PK +KK KK KG KK +K + K
Sbjct: 440 DEESTDADSEPKGDSKKGKKDEKKG-------------------KKDSKKDDKKKDAKKN 480
Query: 343 AESEPREAKKALEVEESNSEDEASFKSE---SAQSSPSNSSSSSDSSSDSDFEPSQNHSQ 399
AES E+ L+ ++ +S+++ K + A+ ++ + D SS + F+ S
Sbjct: 481 AESTEMESDLELKKDKKHSKEKKGSKKDIKKDARKDTESTDAEFDESSKTGFKTST---- 536
Query: 400 GPLRSMVEDLQSEES----------DEDDSSSGEEAAGKTNPGRDSRLSFSDSESDNSAD 449
+ D +SEES DE D +S R R+S + + +
Sbjct: 537 ---KIKGSDTESEESLYKPGAKKKIDESDGTSANSKMEGLESKRGFRMSSKKTTFNEKGE 593
Query: 450 SSLPSREPPPPQKPPPP 466
+ R PP +KPP P
Sbjct: 594 KASTGRVPPSREKPPLP 610
Score = 68.2 bits (165), Expect = 2e-11
Identities = 86/378 (22%), Positives = 158/378 (41%), Gaps = 47/378 (12%)
Query: 90 KNKEEPRKVCFTYDLFLNLEGNPPVNHLRCEKLTFNNPTTEF-RYKLLRAGGVMVMPEGA 148
K+K++ + T FL+ + NP + R + T N+P +E L +M++ +
Sbjct: 198 KDKKDSKNSKKTNTEFLHTKNNPKKDLKRSK--TSNDPISEICSENSLNVDFLMLVGQSD 255
Query: 149 DT-------VSRPSPDYPMLPTIPLSAFSDPKKTKPSHGSKDANKESSKTSKPHKVTKEH 201
D + S + ++ + ++ K + S DA E SK +K K +K+
Sbjct: 256 DESINFDAWLRNYSQNNSKNYSLKYTKYTKKDTKKNAKKSSDAESEDSKDAK--KDSKKV 313
Query: 202 RERPRKDSESKSSSKELEREQAKS--SKDTSR--KLGEGRLPKEEKAPPPKAAFKEPKMA 257
++ +KD + K K+ E A+S SKD + K + +L K++K K K P
Sbjct: 314 KKNVKKDDKKKDVKKDTESTDAESGDSKDERKDTKKDKKKLKKDDKKKDTK---KYP--- 367
Query: 258 LKETKLESTSPKGGPPPPPPPPPRASSKRPATADSPKPSAKKQKKSSSKGSRSAPGTSPR 317
EST + G R K D +KK + K + S S
Sbjct: 368 ------ESTDTESGDAKDARNDSRNLKKASKNDD--------KKKDAKKITFSTDSESEL 413
Query: 318 TSSSSSFSDKKPAKDKSSTRGEKVK-------AESEPR-EAKKALEVEESNSEDEASFKS 369
S S +KK KD + + VK A+SEP+ ++KK + E+ +D K
Sbjct: 414 ESKESQKDEKKDKKDSKTDNKKSVKNDEESTDADSEPKGDSKKGKKDEKKGKKDS---KK 470
Query: 370 ESAQSSPSNSSSSSDSSSDSDFEPSQNHSQGPLRSMVEDLQSEESDEDDSSSGEEAAGKT 429
+ + ++ S++ SD + + + HS+ S + + D + + + + + KT
Sbjct: 471 DDKKKDAKKNAESTEMESDLELKKDKKHSKEKKGSKKDIKKDARKDTESTDAEFDESSKT 530
Query: 430 NPGRDSRLSFSDSESDNS 447
+++ SD+ES+ S
Sbjct: 531 GFKTSTKIKGSDTESEES 548
Score = 51.6 bits (122), Expect = 2e-06
Identities = 78/397 (19%), Positives = 145/397 (36%), Gaps = 45/397 (11%)
Query: 137 RAGGVMVMPEGADTVSRPSPDYPMLPTIPLSAFSDPKKTKPSHGSKDANKESS------- 189
+ G PE V + PL + + +++K S S + N ES
Sbjct: 134 KGGSYATNPESKQIVEEKTKRQNEADKTPLKSSHENEQSKKSKSSSETNPESQNSKTVSK 193
Query: 190 -------KTSKPHKVTKEH----RERPRKDSE-SKSSSKELEREQAKSSKDTSRKLGEGR 237
K SK K T + P+KD + SK+S+ + +++S + + G+
Sbjct: 194 NCSQKDKKDSKNSKKTNTEFLHTKNNPKKDLKRSKTSNDPISEICSENSLNVDFLMLVGQ 253
Query: 238 LPKE----EKAPPPKAAFKEPKMALKETKLESTSPKGGPPPPPPPPPRASSKRPATADSP 293
E + + +LK TK K ++S +
Sbjct: 254 SDDESINFDAWLRNYSQNNSKNYSLKYTKYTKKDTKKN-------AKKSSDAESEDSKDA 306
Query: 294 KPSAKKQKKSSSKGSRSAPGTSPRTSSSSSFSDKKPAKDKSSTRGEKVKAESEPREAKKA 353
K +KK KK+ K + S+ + D K + + +K+K + + ++ KK
Sbjct: 307 KKDSKKVKKNVKKDDKKKDVKKDTESTDAESGDSKDERKDTKKDKKKLKKDDKKKDTKKY 366
Query: 354 LEVEESNSED--EASFKSESAQSSPSNSSSSSDS-----SSDSDFEPSQNHSQGPLR--- 403
E ++ S D +A S + + + N D+ S+DS+ E SQ +
Sbjct: 367 PESTDTESGDAKDARNDSRNLKKASKNDDKKKDAKKITFSTDSESELESKESQKDEKKDK 426
Query: 404 --SMVEDLQSEESDEDDSSSGEEAAGKTNPG-RDSRLSFSDSESDNSADSSLPSREPPPP 460
S ++ +S ++DE+ + + E G + G +D + DS+ D+ + + E
Sbjct: 427 KDSKTDNKKSVKNDEESTDADSEPKGDSKKGKKDEKKGKKDSKKDDKKKDAKKNAE--ST 484
Query: 461 QKPPPPNSKVSGRRSPESCSKPEKILKKGTYDKAYTD 497
+ K + S E + I K D TD
Sbjct: 485 EMESDLELKKDKKHSKEKKGSKKDIKKDARKDTESTD 521
Score = 47.0 bits (110), Expect = 5e-05
Identities = 65/348 (18%), Positives = 128/348 (36%), Gaps = 29/348 (8%)
Query: 173 KKTKPSHGSKDANKESSKTSKPHKVTKEHR----ERPRKDSES-----KSSSKELEREQA 223
KK+K G K+S K + E + E+ ++ +E+ KSS + + +++
Sbjct: 116 KKSKDEKGGTPLKKDSKKKGGSYATNPESKQIVEEKTKRQNEADKTPLKSSHENEQSKKS 175
Query: 224 KSSKDTSRKLGEGRLPKEEKAPPPKAAFKEPKMALKETKLESTSPKGG---PPPPPPPPP 280
KSS +T+ + + + + K K K E +PK P
Sbjct: 176 KSSSETNPESQNSKTVSKNCSQKDKKDSKNSKKTNTEFLHTKNNPKKDLKRSKTSNDPIS 235
Query: 281 RASSKRPATAD-------SPKPSAKKQKKSSSKGSRSAPGTSPRTSSSSSFSDKKPAKDK 333
S+ D S S + ++ S + + + KK AK
Sbjct: 236 EICSENSLNVDFLMLVGQSDDESINFDAWLRNYSQNNSKNYSLKYTKYTKKDTKKNAKKS 295
Query: 334 SSTRGEKVK-AESEPREAKKALEVEESNSEDEASFKSESAQSSPSNSSSSSDSSSDSDFE 392
S E K A+ + ++ KK ++ ++ + + +S A+S S D+ D +
Sbjct: 296 SDAESEDSKDAKKDSKKVKKNVKKDDKKKDVKKDTESTDAESGDS-KDERKDTKKDKK-K 353
Query: 393 PSQNHSQGPLRSMVEDLQSEESDEDDSSSGEEAAGKTNPGRDSRLSFSDSESDNSADSSL 452
++ + + E +E D D+ + K + D + ++S L
Sbjct: 354 LKKDDKKKDTKKYPESTDTESGDAKDARNDSRNLKKASKNDDKKKDAKKITFSTDSESEL 413
Query: 453 PSREPPPPQKPPPPNSKVSGRR-------SPESCSKPEKILKKGTYDK 493
S+E +K +SK ++ S ++ S+P+ KKG D+
Sbjct: 414 ESKESQKDEKKDKKDSKTDNKKSVKNDEESTDADSEPKGDSKKGKKDE 461
Score = 35.0 bits (79), Expect = 0.18
Identities = 34/120 (28%), Positives = 48/120 (40%), Gaps = 13/120 (10%)
Query: 169 FSDPKKT--KPSHGSKDANKESSKTSKPHKVTKEHRERPRKDSESKSSSKELEREQAKSS 226
F + KT K S K ++ ES ++ K+ E + SK E +R SS
Sbjct: 524 FDESSKTGFKTSTKIKGSDTESEESLYKPGAKKKIDESDGTSANSKMEGLESKRGFRMSS 583
Query: 227 KDTS-----RKLGEGRLPKEEKAPPPKAAFKEPKMALKETKLESTSPKGGPPPPPPPPPR 281
K T+ K GR+P + PP A EP + + + PPPPP PR
Sbjct: 584 KKTTFNEKGEKASTGRVPPSREKPPLPAC--EPSLPSPKVRRLCWCKM----PPPPPKPR 637
Score = 29.3 bits (64), Expect = 10.0
Identities = 21/114 (18%), Positives = 47/114 (41%), Gaps = 1/114 (0%)
Query: 290 ADSPKPSAKKQKKSSSKGSRSAPGTSPRTSSSSSFSDKKPAKDKSSTRGEKVKAESEPRE 349
A+ K +K K S+ G+ S ++K + + + +K+ E +
Sbjct: 113 AEYKKSKDEKGGTPLKKDSKKKGGSYATNPESKQIVEEKTKRQNEADK-TPLKSSHENEQ 171
Query: 350 AKKALEVEESNSEDEASFKSESAQSSPSNSSSSSDSSSDSDFEPSQNHSQGPLR 403
+KK+ E+N E + S S S + ++++F ++N+ + L+
Sbjct: 172 SKKSKSSSETNPESQNSKTVSKNCSQKDKKDSKNSKKTNTEFLHTKNNPKKDLK 225
>gi|19718731 bromodomain-containing protein 4 isoform long [Homo
sapiens]
Length = 1362
Score = 70.1 bits (170), Expect = 5e-12
Identities = 78/331 (23%), Positives = 119/331 (35%), Gaps = 41/331 (12%)
Query: 156 PDYPMLPTIPLSAFSDPKKTK----PSHGSKDANKESSKTSKPHKVTKEHRERPRKDSES 211
PD P P + +S+ + P TK PS ++ S S +E +R + E
Sbjct: 458 PDEPEEPVVAVSSPAVPPPTKVVAPPSSSDSSSDSSSDSDSSTDDSEEERAQRLAELQEQ 517
Query: 212 KSS--------SKELEREQAKSSKDTSRKLGEGRLPKEEKAPPPKAAFKEP--KMALKET 261
+ S+ + + K KD K E KEE K+ KEP K K
Sbjct: 518 LKAVHEQLAALSQPQQNKPKKKEKDKKEKKKEKHKRKEEVEENKKSKAKEPPPKKTKKNN 577
Query: 262 KLESTSPKGGPPP-PPPPPPRASSKRPATADSPKPSAKKQKKSSSKGSRSAPGTS----P 316
S K P P PPP S+ D KP + ++K+ S PG
Sbjct: 578 SSNSNVSKKEPAPMKSKPPPTYESEEE---DKCKPMSYEEKRQLSLDINKLPGEKLGRVV 634
Query: 317 RTSSSSSFSDKKPAKDKSSTRGEKVKAESEPREAKKALEVEESNSEDEASFKSESAQSSP 376
S S K D+ E +K + + + +A A SS
Sbjct: 635 HIIQSREPSLKNSNPDEIEIDFETLKPSTLRELERYVTSCLRKKRKPQAEKVDVIAGSSK 694
Query: 377 SNSSSSSDSSSDSDFEPSQNHSQGPLRSMVEDLQSEESDEDDSSSGEEAAGKTNPGRDSR 436
SSS+S S S+ S +S++ ++ ++ K +PGR+ +
Sbjct: 695 MKGFSSSESESSSESS------------------SSDSEDSETEMAPKSKKKGHPGREQK 736
Query: 437 LSFSDSESD-NSADSSLPSREPPPPQKPPPP 466
A + +P + PPPPQ+PPPP
Sbjct: 737 KHHHHHHQQMQQAPAPVPQQPPPPPQQPPPP 767
Score = 48.1 bits (113), Expect = 2e-05
Identities = 36/132 (27%), Positives = 53/132 (40%), Gaps = 18/132 (13%)
Query: 173 KKTKPSHGSKDANKESSK----TSKPHKVTKEHRERPRKDSESKSSSKELE-----REQA 223
KK KP D SSK +S + + E +DSE++ + K + REQ
Sbjct: 677 KKRKPQAEKVDVIAGSSKMKGFSSSESESSSESSSSDSEDSETEMAPKSKKKGHPGREQK 736
Query: 224 KSSKDTSRKLGEGRLPKEEKAPPPKAAFKEPKMALKETKLESTSPKGGPPPPPPPPPRAS 283
K +++ + P ++ PPP P ++ + PPPPPPPP
Sbjct: 737 KHHHHHHQQMQQAPAPVPQQPPPPPQQPPPPPPPQQQQQ---------PPPPPPPPSMPQ 787
Query: 284 SKRPATADSPKP 295
PA SP P
Sbjct: 788 QAAPAMKSSPPP 799
Score = 43.9 bits (102), Expect = 4e-04
Identities = 69/314 (21%), Positives = 110/314 (35%), Gaps = 50/314 (15%)
Query: 245 PPPKAAFKEPKMALKETKLEST--------SPKGGPPP--PPPPPPRASSKRPATADSPK 294
PPP A P A+ + T P PPP P P PP A + +P + P
Sbjct: 215 PPPVQATPHPFPAVTPDLIVQTPVMTVVPPQPLQTPPPVPPQPQPPPAPAPQPVQSHPPI 274
Query: 295 PSAKKQKKSSSKG-SRSAPGTSPRTSSSSSFSDKKPAKDKSSTRGEKVKAESEPREAKKA 353
+A Q + KG R A T+P T P + K++ G++ ++ + KK
Sbjct: 275 IAATPQPVKTKKGVKRKADTTTPTTIDPIHEPPSLPPEPKTTKLGQRRESSRPVKPPKKD 334
Query: 354 LEVEESNSEDEASFK-SESAQS---------SPSNSSSSSDSSSDSDFEPSQNHSQGPLR 403
+ + + E S K SE + + +++ + D E H +
Sbjct: 335 VPDSQQHPAPEKSSKVSEQLKCCSGILKEMFAKKHAAYAWPFYKPVDVEALGLHDYCDII 394
Query: 404 SMVEDLQSEESDEDDSSSGEEAAGKTNPGRDSRLSFSDSESDNSADSSLP---------- 453
D+ + +S E G D RL FS+ N D +
Sbjct: 395 KHPMDMSTIKS----KLEAREYRDAQEFGADVRLMFSNCYKYNPPDHEVVAMARKLQDVF 450
Query: 454 ----SREPPPPQKP---------PPPNSKVSGRRSPESCSKPEKILKKGTYD--KAYTDE 498
++ P P++P PPP V+ S +S S T D +
Sbjct: 451 EMRFAKMPDEPEEPVVAVSSPAVPPPTKVVAPPSSSDSSSDSSSDSDSSTDDSEEERAQR 510
Query: 499 LVELHRRLMALRER 512
L EL +L A+ E+
Sbjct: 511 LAELQEQLKAVHEQ 524
Score = 38.9 bits (89), Expect = 0.013
Identities = 32/135 (23%), Positives = 50/135 (37%), Gaps = 3/135 (2%)
Query: 268 PKGGPPPPPPPPPRASSKRPATADSPKPSAKKQKKSSSKGSRSAPGTSPRT---SSSSSF 324
P+ PPP P + P T +PK K + S T+P + SSS SF
Sbjct: 1165 PEQNAPPPGAPDKDKQKQEPKTPVAPKKDLKIKNMGSWASLVQKHPTTPSSTAKSSSDSF 1224
Query: 325 SDKKPAKDKSSTRGEKVKAESEPREAKKALEVEESNSEDEASFKSESAQSSPSNSSSSSD 384
+ A + R + +KA++E E +K +E E E A+ + + +
Sbjct: 1225 EQFRRAAREKEEREKALKAQAEHAEKEKERLRQERMRSREDEDALEQARRAHEEARRRQE 1284
Query: 385 SSSDSDFEPSQNHSQ 399
E Q Q
Sbjct: 1285 QQQQQRQEQQQQQQQ 1299
Score = 38.5 bits (88), Expect = 0.016
Identities = 39/207 (18%), Positives = 80/207 (38%), Gaps = 12/207 (5%)
Query: 202 RERPRKDSESKSSSKELEREQAKSSKDTSRKLGEGRLPKEEKAPPPKAAFK-----EPKM 256
R P K ES + L + D R + P E+ APPP A K EPK
Sbjct: 1130 RPEPPKHPESIKAPVHLPQRPEMKPVDVGRPVIR---PPEQNAPPPGAPDKDKQKQEPKT 1186
Query: 257 AL---KETKLESTSPKGGPPPPPPPPPRASSKRPATADSPKPSAKKQKKSSSKGSRSAPG 313
+ K+ K+++ P P +++K + + A ++K+ K ++
Sbjct: 1187 PVAPKKDLKIKNMGSWASLVQKHPTTPSSTAKSSSDSFEQFRRAAREKEEREKALKAQAE 1246
Query: 314 TSPRTSSSSSFSDKKPAKDKSS-TRGEKVKAESEPREAKKALEVEESNSEDEASFKSESA 372
+ + + +D+ + + + E+ R+ ++ + +E + + + +A
Sbjct: 1247 HAEKEKERLRQERMRSREDEDALEQARRAHEEARRRQEQQQQQRQEQQQQQQQQAAAVAA 1306
Query: 373 QSSPSNSSSSSDSSSDSDFEPSQNHSQ 399
++P SS S D E ++ Q
Sbjct: 1307 AATPQAQSSQPQSMLDQQRELARKREQ 1333
Score = 35.0 bits (79), Expect = 0.18
Identities = 29/130 (22%), Positives = 52/130 (40%), Gaps = 11/130 (8%)
Query: 186 KESSKTSKPHKVTKEHRERPRKDSESKSSSKELEREQAKSSKDTSRKLGEGRLPKEEKAP 245
K + K + + + SES+SSS+ + S+D+ ++ PK +K
Sbjct: 678 KRKPQAEKVDVIAGSSKMKGFSSSESESSSES----SSSDSEDSETEMA----PKSKKKG 729
Query: 246 PPKAAFKEPKMALKETKLESTSPKGGPPPPPP---PPPRASSKRPATADSPKPSAKKQKK 302
P K+ + ++ +P PPPPP PPP ++ P P + Q+
Sbjct: 730 HPGREQKKHHHHHHQQMQQAPAPVPQQPPPPPQQPPPPPPPQQQQQPPPPPPPPSMPQQA 789
Query: 303 SSSKGSRSAP 312
+ + S P
Sbjct: 790 APAMKSSPPP 799
Score = 34.7 bits (78), Expect = 0.24
Identities = 70/386 (18%), Positives = 123/386 (31%), Gaps = 71/386 (18%)
Query: 144 MPEGADTVSRPSP------DYPML-PTIPLSAFSD-----------PKKTKPSHGSKDAN 185
MP+ A + SP P+L P +P S F P+ P H +
Sbjct: 785 MPQQAAPAMKSSPPPFIATQVPVLEPQLPGSVFDPIGHFTQPILHLPQPELPPHLPQPPE 844
Query: 186 KESSKTSKPHKVTKE---HRERPRKDSESKSSSKELEREQAKSSKDTSRKLGEGRLPKEE 242
+ H V H P++ S + + L + A+ + LP+
Sbjct: 845 HSTPPHLNQHAVVSPPALHNALPQQPSRPSNRAAALPPKPARPPAVSPALTQTPLLPQPP 904
Query: 243 KAPPPKAAFKEPK----------MALKETKLESTSP----------KGGPPPPPPPPPRA 282
A PP+ ++ + M L +L+ P + PPPP PPPP
Sbjct: 905 MAQPPQVLLEDEEPPAPPLTSMQMQLYLQQLQKVQPPTPLLPSVKVQSQPPPPLPPPPHP 964
Query: 283 SSKR-------PATADSPKPSAKKQKKSSSKGSRSAPGTSPRTSSSSSFSDKKPAKDKSS 335
S ++ P P+P ++Q + + P S+ P + +
Sbjct: 965 SVQQQLQQQPPPPPPPQPQPPPQQQHQPPPRPVHLQP-----MQFSTHIQQPPPPQGQQP 1019
Query: 336 TRGEKVKAESEPREAKKALEVEESNSEDEASFKSESAQSSPSNSSSSSDSSSDSDFEPSQ 395
+ P+ AK ++ + SP + S S+ PS
Sbjct: 1020 PHPPPGQQPPPPQPAKPQQVIQHHH--------------SPRHHKSDPYSTGHLREAPSP 1065
Query: 396 NHSQGPLRSMVEDLQSEESDEDDSSSGEEAAGKTNPGRDSRLSFSDSESDNS----ADSS 451
P S + L + + + ++ + + L E +S ++
Sbjct: 1066 LMIHSPQMSQFQSLTHQSPPQQNVQPKKQELRAASVVQPQPLVVVKEEKIHSPIIRSEPF 1125
Query: 452 LPSREPPPPQKPPPPNSKVSGRRSPE 477
PS P PP+ P + V + PE
Sbjct: 1126 SPSLRPEPPKHPESIKAPVHLPQRPE 1151
Score = 29.3 bits (64), Expect = 10.0
Identities = 10/33 (30%), Positives = 20/33 (60%)
Query: 455 REPPPPQKPPPPNSKVSGRRSPESCSKPEKILK 487
++PPPPQ PP+ + P +KP+++++
Sbjct: 1009 QQPPPPQGQQPPHPPPGQQPPPPQPAKPQQVIQ 1041
>gi|148763345 cell division cycle 2-like 2 isoform 4 [Homo sapiens]
Length = 770
Score = 68.2 bits (165), Expect = 2e-11
Identities = 87/369 (23%), Positives = 142/369 (38%), Gaps = 49/369 (13%)
Query: 173 KKTKPSHGSKDANKESSKTSKPHKVTKEHRERPRKDSESKSSSKELER------------ 220
+K K H + KE K ++ + +EH R R E + +E ER
Sbjct: 93 RKEKVHHRKDEKRKEKWKHARVKE--REHERRKRHREEQDKARREWERQKRREMAREHSR 150
Query: 221 ------EQAKSSKDTSRKLGEGRLPKEEKAPPPKAAFKEPK--------MALKETKLEST 266
EQ + ++ RK+ E + + E+ + A + K A T E
Sbjct: 151 RERDRLEQLERKRERERKMREQQKEQREQKERERRAEERRKEREARREVSAHHRTMREDY 210
Query: 267 SPKGGPPPPPPPPPRASSKRPATADSPKP--SAKKQKKSSSKGSRSAPGTSPRTSSSSSF 324
S K PPR +R D KP K +++ + + +TSS+ S
Sbjct: 211 SDKVKASHWSRSPPRPPRERFELGDGRKPVKEEKMEERDLLSDLQDISDSERKTSSAESS 270
Query: 325 SDKKPAKDKSSTRGEKVKAESEPREAKKALEVEESNSEDEASFKSESAQSSPSNSSSSSD 384
S A+ S + E+ + E E E + E EE E+E + + S ++ S+ +
Sbjct: 271 S----AESGSGSEEEEEEEEEEEEEGSTSEESEEEEEEEEEEEEETGSNSEEASEQSAEE 326
Query: 385 SSSDSDFEPSQNHSQGPLRSMVEDLQSEESDEDDSSSGEEAAGKTNPGRDSRLSFSDSES 444
S + E + ++ L + E +S E S EE G+ P + S L+ D
Sbjct: 327 VSEEEMSEDEERENENHLLVVPESRFDRDSGE--SEEAEEEVGEGTP-QSSALTEGDYVP 383
Query: 445 DNSADSSLPSREPPPPQKPPPPNSKVSGRRSPESCSKPEKILKKGTYDKAY------TDE 498
D+ A + ++ P P + G RS E +I ++GTY Y TDE
Sbjct: 384 DSPALLPIELKQELPKYLP-----ALQGCRSVEEFQCLNRI-EEGTYGVVYRAKDKKTDE 437
Query: 499 LVELHRRLM 507
+V L R M
Sbjct: 438 IVALKRLKM 446
>gi|33620755 YEATS domain containing 2 [Homo sapiens]
Length = 1422
Score = 68.2 bits (165), Expect = 2e-11
Identities = 77/321 (23%), Positives = 129/321 (40%), Gaps = 31/321 (9%)
Query: 21 KKPTTEGFTHDWMVFVRGPE-QCDIQHFVEKVVFWLHDSF-PKPRRVCKEPPYKVEESGY 78
K+ + TH WMV+VRG + I HFV+KV F+LH S+ P +EPP+ + G+
Sbjct: 223 KREENDQSTHKWMVYVRGSRREPSINHFVKKVWFFLHPSYKPNDLVEVREPPFHLTRRGW 282
Query: 79 AGFIMPIEVHFKNKEEPRKVCFTYDLFLNLEGNPPVNHLRCEKLTFNNPTTEFRYKLLRA 138
F + ++VHFK+ + R D+ NL+ + L+ R+ L
Sbjct: 283 GEFPVRVQVHFKDSQNKR-----IDIIHNLKLDRTYTGLQTLGAETVVDVELHRHSL--- 334
Query: 139 GGVMVMPEGADTVSRPSPDYPMLPTIPLSAFSDPKKTKPSHGSKDANKESSKTSKPHKVT 198
G + P+ +++ +P P++PL+ + K + P S + ++S T
Sbjct: 335 GEDCIYPQSSESDISDAP-----PSLPLTIPAPVKASSPIKQSHEPVPDTSVEKGFPAST 389
Query: 199 KEHRERPRKDSESKSSSKELEREQAKSSKDTSRKLGEG---------RLPKEEKAPPPKA 249
+ R P SS + + S K T G ++ + + P P++
Sbjct: 390 EAERHTP--FYALPSSLERTPTKMTTSQKVTFCSHGNSAFQPIASSCKIVPQSQVPNPES 447
Query: 250 AFKEPKMALKETKLESTSPKGGPPPPPPPPPRASSK---RPATADS--PKPSAKKQKKSS 304
K + K+ S SP P P P P S+ + TA S P K+
Sbjct: 448 PGKSFQPITMSCKIVSGSPISTPSPSPLPRTPTSTPVHVKQGTAGSVINNPYVIMDKQPG 507
Query: 305 SKGSRSAPGTSPRTSSSSSFS 325
+ P T T+ S+ S
Sbjct: 508 QVIGATTPSTGSPTNKISTAS 528
>gi|132626688 mediator of DNA-damage checkpoint 1 [Homo sapiens]
Length = 2089
Score = 67.4 bits (163), Expect = 3e-11
Identities = 79/354 (22%), Positives = 141/354 (39%), Gaps = 34/354 (9%)
Query: 150 TVSRPSPDYPMLPTIPLSAFSD-PKKTKPSHGSKDANKESSKTSKPHKVTKEHRE-RPRK 207
+V P P P P + S +D P ++P++ + K S P V E RP
Sbjct: 1236 SVKTPEPVVPTAPELQPSTSTDQPVTSEPTYQATRGRKNRSSVKTPEPVVPTAPELRPST 1295
Query: 208 DSESKSSSKELEREQAKSSKDTSRKLGEGRLPKEEKAPPPKAAFKE--PKMALKETKLES 265
++ + K R + +S K E +P + + + PK + T+ +
Sbjct: 1296 STDRPVTPKPTSRTTRSRTNMSSVKTPETVVPTAPELQISTSTDQPVTPKPTSRTTRSRT 1355
Query: 266 T-----SPKGGPPPPPPPPPRASSKRPATADSPKPSAK----KQKKSSSKGSRSAPGTSP 316
+P+ P P PP S+++P T P+P+++ ++ +SS K + T+P
Sbjct: 1356 NMSSVKNPESTVPIAPELPPSTSTEQPVT---PEPTSRATRGRKNRSSGKTPETLVPTAP 1412
Query: 317 RTSSSSSFSDK-KPAKDKSSTRGEKVKAESEPRE--AKKALEVEESNSEDEASFKSESAQ 373
+ S+S P +TRG ++ + E A E++ S S D+ ++Q
Sbjct: 1413 KLEPSTSTDQPVTPEPTSQATRGRTNRSSVKTPETVVPTAPELQPSTSTDQPVTPEPTSQ 1472
Query: 374 SSPSNSSSSSDSSSDSDFEPSQNHSQGPLRSMVEDLQSEESDEDDSSSGEEAAGKTNPGR 433
++ + SS + ++ + +LQ+ S + +S E +T GR
Sbjct: 1473 ATRGRTDRSSVKTPET------------VVPTAPELQASASTDQPVTS--EPTSRTTRGR 1518
Query: 434 DSRLSFSDSESDNSADSSL-PSREPPPPQKPPPPNSKVSGRRSPESCSKPEKIL 486
+R S E+ A L PS P P P + GR + S PE I+
Sbjct: 1519 KNRSSVKTPETVVPAAPELQPSTSTDQPVTPEPTSRATRGRTNRSSVKTPESIV 1572
Score = 52.8 bits (125), Expect = 8e-07
Identities = 71/341 (20%), Positives = 119/341 (34%), Gaps = 44/341 (12%)
Query: 172 PKKTKPSHGSKDANKESSKTSKPHKVTKEHRERPRKDSESKSSSKELEREQAKSSKDTSR 231
P++ G ++ K + + ++ +R D +S+S E +RE K +TS
Sbjct: 840 PERQTDVTGEEELTKGKQDREQKQLLARD-TQRQESDKNGESASPERDRESLKVEIETSE 898
Query: 232 KLGEGRLPKE-----------------EKAPPPKAAFKEPKMALK------ETKLESTSP 268
++ E ++ K+ + P + K PK+ L+ E + S
Sbjct: 899 EIQEKQVQKQTLPSKAFEREVERPVANRECDPAELEEKVPKVILERDTQRGEPEGGSQDQ 958
Query: 269 KGGPPPPPPPPPRASSKRPATADSPKPSAKKQKKSSSKGSRSAPGTSPRTSSSSSFSDKK 328
KG P P P + P +P PS S G R +P SPR + K
Sbjct: 959 KGQASSPTPEPGVGAGDLPGPTSAPVPS------GSQSGGRGSP-VSPRRHQKGLLNCKM 1011
Query: 329 PAKDKSS--TRGEKV-KAESEPREAKKALEVEESNSEDEASFKSESAQSSPSNSSSSSDS 385
P +K+S EKV + + E +A V E+ + + P NS S
Sbjct: 1012 PPAEKASRIRAAEKVSRGDQESPDACLPPTVPEAPAPPQ----------KPLNSQSQKHL 1061
Query: 386 SSDSDFEPSQNHSQGPLRSMVEDLQSEESDEDDSSSGEEAAGKTNPGRDSRLSFSDSESD 445
+ P + +R +D E + SS E K + +
Sbjct: 1062 APPPLLSPLLPSIKPTVRKTRQDGSQEAPEAPLSSELEPFHPKPKIRTRKSSRMTPFPAT 1121
Query: 446 NSADSSLPSREPPPPQKPPPPNSKVSGRRSPESCSKPEKIL 486
++A PS P P P + R + S PE ++
Sbjct: 1122 SAAPEPHPSTSTAQPVTPKPTSQATRSRTNRSSVKTPEPVV 1162
Score = 44.7 bits (104), Expect = 2e-04
Identities = 74/357 (20%), Positives = 121/357 (33%), Gaps = 57/357 (15%)
Query: 171 DPKKTKPSHGSKDANKESSKTSKPHKVTKEHRERPRKDSESKSSSKELEREQAKSSKDTS 230
D ++ +P GS+D ++S + V P + S S+ R S +
Sbjct: 945 DTQRGEPEGGSQDQKGQASSPTPEPGVGAGDLPGPTS-APVPSGSQSGGRGSPVSPRRHQ 1003
Query: 231 RKLGEGRLPKEEKAPPPKAAFK-------EPKMALKETKLESTSPKGGP---------PP 274
+ L ++P EKA +AA K P L T E+ +P P P
Sbjct: 1004 KGLLNCKMPPAEKASRIRAAEKVSRGDQESPDACLPPTVPEAPAPPQKPLNSQSQKHLAP 1063
Query: 275 PPPPPPRASSKRPATADS---------------------PKPSAKKQKKSSSK---GSRS 310
PP P S +P + PKP + +K S + +
Sbjct: 1064 PPLLSPLLPSIKPTVRKTRQDGSQEAPEAPLSSELEPFHPKPKIRTRKSSRMTPFPATSA 1123
Query: 311 APGTSPRTSSSSSFSDKKPAKDKSSTRGEKVKAESEPREAKKALEVEESNSEDEASFKSE 370
AP P TS++ + K P + +R + ++ A E++ S S D+
Sbjct: 1124 APEPHPSTSTAQPVTPK-PTSQATRSRTNRSSVKTPEPVVPTAPELQPSTSTDQPVTSEP 1182
Query: 371 SAQSSPSNSSSSSDSSSDSDFEPSQNHSQGPLRSMVEDLQSEESDEDDSSSGEEAAGKTN 430
++Q + S SS + P + L+ + S D E +
Sbjct: 1183 TSQVTRGRKSRSSVKT--------------PETVVPTALELQPSTSTDRPVTSEPTSQAT 1228
Query: 431 PGRDSRLSFSDSES-DNSADSSLPSREPPPPQKPPPPNSKVSGRRSPESCSKPEKIL 486
GR +R S E +A PS P P GR++ S PE ++
Sbjct: 1229 RGRKNRSSVKTPEPVVPTAPELQPSTSTDQPVTSEPTYQATRGRKNRSSVKTPEPVV 1285
Score = 40.8 bits (94), Expect = 0.003
Identities = 55/271 (20%), Positives = 103/271 (38%), Gaps = 25/271 (9%)
Query: 185 NKESSKTSKPHKVTKEHRERPRKDSES----KSSSKELEREQAKSSKDTSRKLGEGRLPK 240
N+ S KT +P V P ++ K +S+ R+ +SS T + +
Sbjct: 1602 NRSSVKTPEP-VVPTAPEPHPTTSTDQPVTPKLTSRATRRKTNRSSVKTPKPVEPAASDL 1660
Query: 241 EEKAPPPKAAFKEPKMALKETK-LESTSPKGGPPPPPPPPPRASSKRPATADSP------ 293
E P ++ E ++K L S++ + P P P + P T D P
Sbjct: 1661 EPFTPTDQSVTPEAIAQGGQSKTLRSSTVRAMPVPTTP-----EFQSPVTTDQPISPEPI 1715
Query: 294 -KPSA-KKQKKSSSKGSRSAP-----GTSPRTSSSSSFSDKKPAKDKSSTRGEKVKAESE 346
+PS K+Q+ + + GS +AP ++P S + +++ +++ + +
Sbjct: 1716 TQPSCIKRQRAAGNPGSLAAPIDHKPCSAPLEPKSQASRNQRWGAVRAAESLTAIPEPAS 1775
Query: 347 PREAKKALEVEESNSEDEASFKSESAQSSPSNSSSSSDSSSDSDFEPSQNHSQ-GPLRSM 405
P+ + + + + A + + P S S S + D P Q Q G +
Sbjct: 1776 PQLLETPIHASQIQKVEPAGRSRFTPELQPKASQSRKRSLATMDSPPHQKQPQRGEVSQK 1835
Query: 406 VEDLQSEESDEDDSSSGEEAAGKTNPGRDSR 436
++ EE D + EE PG+ R
Sbjct: 1836 TVIIKEEEEDTAEKPGKEEDVVTPKPGKRKR 1866
Score = 38.9 bits (89), Expect = 0.013
Identities = 68/346 (19%), Positives = 129/346 (37%), Gaps = 31/346 (8%)
Query: 150 TVSRPSPDYPMLPTIPLSAFSD-PKKTKPSHGSKDANKESSKTSKPHKVTKEHRE-RPRK 207
+V P P P + SA +D P ++P+ + K S P V E +P
Sbjct: 1482 SVKTPETVVPTAPELQASASTDQPVTSEPTSRTTRGRKNRSSVKTPETVVPAAPELQPST 1541
Query: 208 DSESKSSSKELEREQAKSSKDTSRKLGEGRLPKEEKAPPPKAAFK--EPKMALKETKLES 265
++ + + R + +S K E +P + P + + P+ + T+ +
Sbjct: 1542 STDQPVTPEPTSRATRGRTNRSSVKTPESIVPIAPELQPSTSRNQLVTPEPTSRATRCRT 1601
Query: 266 T-----SPKGGPPPPPPPPPRASSKRPATAD-SPKPSAKKQKKSSSKGSR----SAPGTS 315
+P+ P P P P S+ +P T + + + +K +SS K + +A
Sbjct: 1602 NRSSVKTPEPVVPTAPEPHPTTSTDQPVTPKLTSRATRRKTNRSSVKTPKPVEPAASDLE 1661
Query: 316 PRTSSSSSFSDKKPAK--DKSSTRGEKVKAESEPR--EAKKALEVEESNSED----EASF 367
P T + S + + A+ + R V+A P E + + ++ S + +
Sbjct: 1662 PFTPTDQSVTPEAIAQGGQSKTLRSSTVRAMPVPTTPEFQSPVTTDQPISPEPITQPSCI 1721
Query: 368 KSESAQSSPSNSSSSSD-SSSDSDFEPSQNHSQGPLRSMVEDLQSEESDEDDSSS----- 421
K + A +P + ++ D + EP S+ V +S + + +S
Sbjct: 1722 KRQRAAGNPGSLAAPIDHKPCSAPLEPKSQASRNQRWGAVRAAESLTAIPEPASPQLLET 1781
Query: 422 --GEEAAGKTNPGRDSRLSFS-DSESDNSADSSLPSREPPPPQKPP 464
K P SR + ++ S SL + + PP QK P
Sbjct: 1782 PIHASQIQKVEPAGRSRFTPELQPKASQSRKRSLATMDSPPHQKQP 1827
>gi|21361282 splicing factor, arginine/serine-rich 4 [Homo sapiens]
Length = 494
Score = 66.2 bits (160), Expect = 7e-11
Identities = 73/304 (24%), Positives = 129/304 (42%), Gaps = 23/304 (7%)
Query: 181 SKDANKESSKTSKPHKVTKEHRERPRKDSESKSSSKELEREQAKSSKDTSRKLGEGRLPK 240
S+ + K S++ + R R R S S+S S+ + +++S K+ SR P
Sbjct: 198 SRHSRKSRSRSGSSKSSHSKSRSRSRSGSRSRSKSRSRSQSRSRSKKEKSRS------PS 251
Query: 241 EEKAPPPKAAFKEPKMALK---ETKLESTSPKGGPPPPPPPPPRASSKRPATADSPKPSA 297
+EK+ + + + K E K+++ G P P R SK + + S +
Sbjct: 252 KEKSRSRSHSAGKSRSKSKDQAEEKIQNNDNVG--KPKSRSPSRHKSKSKSRSRSQERRV 309
Query: 298 KKQKKSSSKGSRSAPGTSPRTSSSSSFSDKKPAKDKSSTRGEKVKAESEPREAKKALEVE 357
+++K+ S RS S R S S S S K S +R + R+ +K E
Sbjct: 310 EEEKRGSVSRGRSQE-KSLRQSRSRSRS-----KGGSRSRSRSRSKSKDKRKGRKRSR-E 362
Query: 358 ESNSEDEASFKSESAQSSPSNSSSSSDSSSDSDFEPS-QNHSQGPLRSMVEDLQSEESDE 416
ES S + KSE ++ S S + SS E + ++ S+ P RS+ ++ + +S+
Sbjct: 363 ESRSRSRSRSKSERSRKRGSKRDSKAGSSKKKKKEDTDRSQSRSPSRSVSKEREHAKSE- 421
Query: 417 DDSSSGEEAAGKTNPGRDSRLSFSDSESDNSADSSLPSREPPPPQKPPPPNSKVSGRRSP 476
SS E G++ ++ + S S S++ + +LPS + S+ R
Sbjct: 422 ---SSQREGRGESENAGTNQETRSRSRSNSKSKPNLPSESRSRSKSASKTRSRSKSRSRS 478
Query: 477 ESCS 480
S S
Sbjct: 479 ASRS 482
Score = 59.3 bits (142), Expect = 9e-09
Identities = 57/270 (21%), Positives = 107/270 (39%), Gaps = 14/270 (5%)
Query: 174 KTKPSHGSKDANKESSKT-----SKPHKVTKEHRERPRKDSESKSSSKELEREQAKSSKD 228
+++ GS+ +K S++ SK K +E+ R S S S+ ++QA+
Sbjct: 219 RSRSRSGSRSRSKSRSRSQSRSRSKKEKSRSPSKEKSRSRSHSAGKSRSKSKDQAEEKIQ 278
Query: 229 TSRKLG--EGRLPKEEKAPPPKAAFKEPKMALKETKLESTSPKGGPPPPPPPPPRASSKR 286
+ +G + R P K+ + + + +E + + + R+ SK
Sbjct: 279 NNDNVGKPKSRSPSRHKSKSKSRSRSQERRVEEEKRGSVSRGRSQEKSLRQSRSRSRSKG 338
Query: 287 PATADSPKPSAKKQKKSSSKGSRSAPGTSPRTSSSSSFSDKKPAKDKSSTRGEKVKAESE 346
+ + S S K K+ K SR + R+ S S S K+ +K + S G K + E
Sbjct: 339 GSRSRSRSRSKSKDKRKGRKRSREESRSRSRSRSKSERSRKRGSK-RDSKAGSSKKKKKE 397
Query: 347 PREAKKALEVEESNSEDEASFKSESAQSSPSNSSSSSDSSSDSDFEPSQNHSQGPLRSMV 406
+ ++ S S++ KSES+Q S ++ ++ ++ N P
Sbjct: 398 DTDRSQSRSPSRSVSKEREHAKSESSQREGRGESENAGTNQETRSRSRSNSKSKP----- 452
Query: 407 EDLQSEESDEDDSSSGEEAAGKTNPGRDSR 436
+L SE S+S + K+ SR
Sbjct: 453 -NLPSESRSRSKSASKTRSRSKSRSRSASR 481
Score = 58.5 bits (140), Expect = 2e-08
Identities = 71/264 (26%), Positives = 111/264 (42%), Gaps = 37/264 (14%)
Query: 174 KTKPSHGSKDANKESSKTSKPHKVTKEHRERPRKDSESKSSSKELEREQAK--------- 224
+++ S+ ++ SK K +KE + R R S KS SK ++ + K
Sbjct: 227 RSRSKSRSRSQSRSRSKKEKSRSPSKE-KSRSRSHSAGKSRSKSKDQAEEKIQNNDNVGK 285
Query: 225 ---------SSKDTSRKLGEGRLPKEEKAPPPKAAFKEPKMALKETKLESTSPKGGPPPP 275
SK SR + R +EEK + K +L++++ S S KGG
Sbjct: 286 PKSRSPSRHKSKSKSRSRSQERRVEEEKRGSVSRGRSQEK-SLRQSRSRSRS-KGGSRSR 343
Query: 276 PPPPPRASSKRPATADSPKPSAKKQKKSSSKGSRSAPGTSPRTSSS-SSFSDKKPAKDKS 334
++ KR S + S + + +S SK RS S R S + SS KK D+S
Sbjct: 344 SRSRSKSKDKRKGRKRSREES-RSRSRSRSKSERSRKRGSKRDSKAGSSKKKKKEDTDRS 402
Query: 335 STRG---------EKVKAESEPREAKKALEVEESNSEDEASFK--SESAQSSPSNSSSSS 383
+R E K+ES RE + E +N E + + S+S + PS S S S
Sbjct: 403 QSRSPSRSVSKEREHAKSESSQREGRGESENAGTNQETRSRSRSNSKSKPNLPSESRSRS 462
Query: 384 DSSSDS---DFEPSQNHSQGPLRS 404
S+S + S++ S+ P RS
Sbjct: 463 KSASKTRSRSKSRSRSASRSPSRS 486
Score = 54.3 bits (129), Expect = 3e-07
Identities = 66/273 (24%), Positives = 109/273 (39%), Gaps = 20/273 (7%)
Query: 227 KDTSRKLGEGRLPKEEKAPPPKA-----AFKEPKMALKETKLESTSPKGGPPPPPPPPPR 281
KD R+ GE K + ++ + K AL+ KL+ T G P
Sbjct: 121 KDYMRQAGEVTYADAHKGRKNEGVIEFVSYSDMKRALE--KLDGTEVNGRKIRLVEDKP- 177
Query: 282 ASSKRPATADSPKPSAKKQKKSSSKGSRSAPGTSPRTSSSSSFSDKKPAKDKSSTRGEKV 341
S +R + + S S + + S+ SRS G+S + S S + ++ +S +R
Sbjct: 178 GSRRRRSYSRSRSHSRSRSRSRHSRKSRSRSGSSKSSHSKSRSRSRSGSRSRSKSRS--- 234
Query: 342 KAESEPREAKKALEVEESNSEDEASFKSESAQSSPSNSSSSSDSSSDSDFEPSQNHSQGP 401
+++S R K E S S++++ +S SA S S S ++ ++ + S+ P
Sbjct: 235 RSQSRSRSKK---EKSRSPSKEKSRSRSHSAGKSRSKSKDQAEEKIQNNDNVGKPKSRSP 291
Query: 402 LRSMVEDLQSEESDEDDSSSGEEAAGKTNPGRDS----RLSFSDSESDNSADSSLPSREP 457
R + S E EE G + GR R S S S S + S SR
Sbjct: 292 SRHKSKSKSRSRSQE--RRVEEEKRGSVSRGRSQEKSLRQSRSRSRSKGGSRSRSRSRSK 349
Query: 458 PPPQKPPPPNSKVSGRRSPESCSKPEKILKKGT 490
++ S+ R S SK E+ K+G+
Sbjct: 350 SKDKRKGRKRSREESRSRSRSRSKSERSRKRGS 382
Score = 47.0 bits (110), Expect = 5e-05
Identities = 38/167 (22%), Positives = 79/167 (47%), Gaps = 11/167 (6%)
Query: 173 KKTKPSHGSKDANKESSKTSKPHKVTKEHRERPRKDSESKSSSK-ELEREQAKSSKDTSR 231
++++ SK ++ S++ K ++ R+R R++S S+S S+ + ER + + SK S+
Sbjct: 328 RQSRSRSRSKGGSRSRSRSRSKSKDKRKGRKRSREESRSRSRSRSKSERSRKRGSKRDSK 387
Query: 232 KLGEGRLPKEEKAPPPKAAFKEPKMAL----KETKLESTSPKGGPPPPPPPPPRASSKRP 287
G K++K ++ + P ++ + K ES+ +G + + R
Sbjct: 388 ---AGSSKKKKKEDTDRSQSRSPSRSVSKEREHAKSESSQREGRGESENAGTNQETRSRS 444
Query: 288 ATADSPKPSAKKQKKSSSKGSRSAPGTSPRTSSSSSFSDKKPAKDKS 334
+ KP+ + +S SK SA T R+ S S + + P++ +S
Sbjct: 445 RSNSKSKPNLPSESRSRSK---SASKTRSRSKSRSRSASRSPSRSRS 488
>gi|5174573 myeloid/lymphoid or mixed-lineage leukemia trithorax
homolog 2 [Homo sapiens]
Length = 1210
Score = 66.2 bits (160), Expect = 7e-11
Identities = 96/387 (24%), Positives = 146/387 (37%), Gaps = 91/387 (23%)
Query: 172 PKKTKPSHGSKDANKESSKTSKPHKVTKEHR--ERPRKDSESKSSSKELEREQAKSSKDT 229
P+ P+ + +K S+P + R E PR+ ESK SS ++ SKD
Sbjct: 503 PEPEPPTTNKWQLDNWLTKVSQPAAPPEGPRSTEPPRRHPESKGSSDSATSQEHSESKD- 561
Query: 230 SRKLGEGRLPKEEKAPPPKAAFKEPKMALKETKLESTSPKGGPPPPPPPPPRASSKRPAT 289
PPPK++ K P+ PP P P R+ K PA
Sbjct: 562 ---------------PPPKSSSKAPR---------------APPEAPHPGKRSCQKSPAQ 591
Query: 290 ADSP-------KPSAKKQKKSSSKGSRSA------PGTSPRTSSSSSFSDKKPAKDKSST 336
+ P K K K S+ GSR++ PG P S + DK K K
Sbjct: 592 QEPPQRQTVGTKQPKKPVKASARAGSRTSLQGEREPGLLPYGSRDQTSKDKPKVKTKGRP 651
Query: 337 RGEKVKAESEPREAKKALEVEESNSEDEASFKSESAQSSPSNSSSSSDSSSDSDFEPSQN 396
R A +EP+ A V S+ + K +S+ +PS + S + + D+ + +
Sbjct: 652 R---AAASNEPKPA-----VPPSSEKK----KHKSSLPAPSKALSGPEPAKDNVEDRTPE 699
Query: 397 H-SQGPLRSMVEDLQSEESDEDDSSSGEEAAGKTNPGRDSRLSFSDSESDN----SADSS 451
H + PL +E S SG +G R + + DS D D+
Sbjct: 700 HFALVPL--------TESQGPPHSGSGSRTSG----CRQAVVVQEDSRKDRLPLPLRDTK 747
Query: 452 L--PSREPPPPQ------------KPPPPNSKVSGRRSPESCSKPEKILKKGTYDKAYTD 497
L P R+ PPPQ + P P K S +R E P KK + +K +D
Sbjct: 748 LLSPLRDTPPPQSLMVKITLDLLSRIPQPPGKGSRQRKAEDKQPPAG--KKHSSEKRSSD 805
Query: 498 ELVELHRRLMALRERNVLQQIVNLIEE 524
+L ++ ER+ + + L +E
Sbjct: 806 SSSKLAKKRKGEAERDCDNKKIRLEKE 832
Score = 53.5 bits (127), Expect = 5e-07
Identities = 64/234 (27%), Positives = 104/234 (44%), Gaps = 32/234 (13%)
Query: 176 KPSHGSKDANKESSKTSKPHKVTKEHRERPRKDSESKSSSKELEREQAKSSKDTSRKLGE 235
+P G K ++++ S S K+ K+ + +D ++K E E + SS +S K
Sbjct: 790 QPPAGKKHSSEKRSSDSSS-KLAKKRKGEAERDCDNKKIRLEKEIKSQSSSSSSSHKESS 848
Query: 236 GRLP--------KEEKAPPP---KAAFKEPKMALKETKLESTSPKGGPPPPPPPPPRASS 284
P K+E PPP ++ K K ALK ++ E+ + PP ASS
Sbjct: 849 KTKPSRPSSQSSKKEMLPPPPVSSSSQKPAKPALKRSRREADT------CGQDPPKSASS 902
Query: 285 KRPATADSPKPSAKKQKKSSSKGSRSA---PGTSPRTSS-----SSSFSDKKPAKDKSST 336
+ DS P KQ++ KGSRS+ G+S T++ S + KP K +
Sbjct: 903 TKSNHKDSSIP---KQRRVEGKGSRSSSEHKGSSGDTANPFPVPSLPNGNSKPGKPQ--V 957
Query: 337 RGEKVKAESEPREAKKALEVEESNSEDEA-SFKSESAQSSPSNSSSSSDSSSDS 389
+ +K +A+ REAKK + E ++ +FK A S +++S S S
Sbjct: 958 KFDKQQADLHMREAKKMKQKAELMTDRVGKAFKYLEAVLSFIECGIATESESQS 1011
Score = 52.4 bits (124), Expect = 1e-06
Identities = 77/345 (22%), Positives = 126/345 (36%), Gaps = 43/345 (12%)
Query: 181 SKDANKESSKTSKPHKVTKEHRERPRKDSESKSSSKELER-EQAKSSKDTSRKLGEGRLP 239
SKD K +K + E + SE K L +A S + ++ E R P
Sbjct: 639 SKDKPKVKTKGRPRAAASNEPKPAVPPSSEKKKHKSSLPAPSKALSGPEPAKDNVEDRTP 698
Query: 240 K--------EEKAPPPKAAFKEPKMALKETKLESTSPKGGPPPPPPPPPRASSKRPATAD 291
+ E + PP + + ++ S K P P S R D
Sbjct: 699 EHFALVPLTESQGPPHSGSGSRTSGCRQAVVVQEDSRKDRLPLPLRDTKLLSPLR----D 754
Query: 292 SPKPSAKKQK----------KSSSKGSRSAPGTSPRTSSSSSFSDKKPAKDKSSTRGEKV 341
+P P + K + KGSR + + S +K + D SS +K
Sbjct: 755 TPPPQSLMVKITLDLLSRIPQPPGKGSRQRKAEDKQPPAGKKHSSEKRSSDSSSKLAKKR 814
Query: 342 KAESEPREAKKALEVE---ESNSEDEASFKSESAQSSPSNSSSSSDSSSDSDFEPSQNHS 398
K E+E K + +E +S S +S ES+++ PS SS S P + S
Sbjct: 815 KGEAERDCDNKKIRLEKEIKSQSSSSSSSHKESSKTKPSRPSSQSSKKEMLPPPPVSSSS 874
Query: 399 QGPLRSMVEDLQSEE----SDEDDSSSGEEAAGKTN--------PGRDSRLSFSDSESDN 446
Q P + ++ + E D S+S ++ K + G+ SR S +
Sbjct: 875 QKPAKPALKRSRREADTCGQDPPKSASSTKSNHKDSSIPKQRRVEGKGSR--SSSEHKGS 932
Query: 447 SADSSLPSREPPPP---QKPPPPNSKVSGRRSPESCSKPEKILKK 488
S D++ P P P KP P K +++ + +K+ +K
Sbjct: 933 SGDTANPFPVPSLPNGNSKPGKPQVKFDKQQADLHMREAKKMKQK 977
Score = 50.8 bits (120), Expect = 3e-06
Identities = 83/364 (22%), Positives = 119/364 (32%), Gaps = 102/364 (28%)
Query: 213 SSSKELEREQAKSSKDTSRKLGEGRLPKEEKAPPPKAAFKEPKMALKETKLESTSPKGGP 272
S+ + L R Q S S +G P K+P A K+ KET +S P
Sbjct: 216 SNQQTLPRTQGSSKVHGSSNNSKGYCPA--KSPKDLAV----KVHDKETPQDSLVAPAQP 269
Query: 273 PPPPPPPPRASSKRPATADSPKPSAKKQKKSSSKGSRSAPGTSP---------RTSSSSS 323
P PPP SK A P + G AP SP R +
Sbjct: 270 PSQTFPPPSLPSKSVAMQQKPTAYVRPMD-----GQDQAPSESPELKPLPEDYRQQTFEK 324
Query: 324 FSDKKPAKDKSSTRGEKVKAESEPREAKKALEVE---------------------ESNSE 362
K PAK K + K+K S+ E + EV ++
Sbjct: 325 TDLKVPAKAKLT----KLKMPSQSVEQTYSNEVHCVEEILKEMTHSWPPPLTAIHTPSTA 380
Query: 363 DEASFKSESAQSSPSNSSSSSDSSSDSDFEPSQNHSQGPLRSMVEDLQSEESDEDDSSSG 422
+ + F + S +S + + D+ + N QG + +DLQ +S++ DS
Sbjct: 381 EPSKFPFPTKDSQHVSSVTQNQKQYDTSSKTHSNSQQGTSSMLEDDLQLSDSEDSDSEQT 440
Query: 423 EE-------------------AAGKTNPGRDSRLSFSDSESDNSADSS-----------L 452
E A+ ++ S SDS SD+ ++SS
Sbjct: 441 PEKPPSSSAPPSAPQSLPEPVASAHSSSAESESTSDSDSSSDSESESSSSDSEENEPLET 500
Query: 453 PSREPPPP------------------QKPPPPNSKVSGRRSPESCSKPEKILKKGTYDKA 494
P+ EP PP P P S RR PES KG+ D A
Sbjct: 501 PAPEPEPPTTNKWQLDNWLTKVSQPAAPPEGPRSTEPPRRHPES---------KGSSDSA 551
Query: 495 YTDE 498
+ E
Sbjct: 552 TSQE 555
Score = 46.6 bits (109), Expect = 6e-05
Identities = 70/360 (19%), Positives = 119/360 (33%), Gaps = 34/360 (9%)
Query: 165 PLSAFSDPKKTKPSH---GSKDANKESSKTSKPHKVTKEHRERPRKDSESKSSSKELERE 221
PL+A P +PS +KD+ SS T + + + +S+ +SS +
Sbjct: 370 PLTAIHTPSTAEPSKFPFPTKDSQHVSSVTQNQKQY--DTSSKTHSNSQQGTSSMLEDDL 427
Query: 222 QAKSSKDTSRKLGEGRLPKEEKAPPPKAAFKEPKMALKETKLESTSPKGGPPPPPPPPPR 281
Q S+D+ + + P P + EP + + ES S
Sbjct: 428 QLSDSEDSDSEQTPEKPPSSSAPPSAPQSLPEPVASAHSSSAESES-------------- 473
Query: 282 ASSKRPATADSPKPSAKKQKKSSSKGSRSAPGTSPRTSSSSSFSDKKPAKDKSSTRGEKV 341
+S +++DS S+ + + AP P T++ + + + E
Sbjct: 474 -TSDSDSSSDSESESSSSDSEENEPLETPAPEPEPPTTNKWQLDNWLTKVSQPAAPPEGP 532
Query: 342 KAESEPR-------EAKKALEVEESNSED---EASFKSESAQSSPSNSSSSSDSSSDSDF 391
++ PR + A E S S+D ++S K+ A + S S +
Sbjct: 533 RSTEPPRRHPESKGSSDSATSQEHSESKDPPPKSSSKAPRAPPEAPHPGKRSCQKSPAQQ 592
Query: 392 EPSQNHSQGPLRSMVEDLQSEESDEDDSSSGEEAAGKTNPGRDSRLSFSDSESDNSADSS 451
EP Q + G + S + S GE G G + S +
Sbjct: 593 EPPQRQTVGTKQPKKPVKASARAGSRTSLQGEREPGLLPYGSRDQTSKDKPKVKTKGRPR 652
Query: 452 LPSREPPPPQKPPPPNSKVSGRRSPESCSKPEKILKKGTYDKAYTDELVELHRRLMALRE 511
+ P P PP K + S P K L K ++ H L+ L E
Sbjct: 653 AAASNEPKPAVPPSSEKK----KHKSSLPAPSKALSGPEPAKDNVEDRTPEHFALVPLTE 708
Score = 46.6 bits (109), Expect = 6e-05
Identities = 69/332 (20%), Positives = 116/332 (34%), Gaps = 42/332 (12%)
Query: 177 PSHGSKDANKESSKTSKPHKVT--KEHRERPRKDSESKSSSKELEREQA----------K 224
P G + K ++ P + T + ++P K S S L+ E+ +
Sbjct: 578 PHPGKRSCQKSPAQQEPPQRQTVGTKQPKKPVKASARAGSRTSLQGEREPGLLPYGSRDQ 637
Query: 225 SSKDTSRKLGEGRLPKEEKAPPPKAAFKEPKMALKETKLESTSPKGGPPPPPPPPPRASS 284
+SKD + +GR P+ + PK A P K+ K +P P P
Sbjct: 638 TSKDKPKVKTKGR-PRAAASNEPKPAVP-PSSEKKKHKSSLPAPSKALSGPEPAKDNVED 695
Query: 285 KRPATADSPKPSAKKQKKSSSKGSRSAPGTSPRTSSSSSFSDKKPAKDKSSTRGEKVKAE 344
+ P + + S GSR++ S D+ P + + ++
Sbjct: 696 RTPEHFALVPLTESQGPPHSGSGSRTSGCRQAVVVQEDSRKDRLPLPLRDTKLLSPLRDT 755
Query: 345 SEPREAKKALEVE----------ESNSEDEASFKSESAQSSPSNSSSSSDSSSDSDFEPS 394
P+ + ++ + + + +A K A S+ SSDSSS +
Sbjct: 756 PPPQSLMVKITLDLLSRIPQPPGKGSRQRKAEDKQPPAGKKHSSEKRSSDSSSKLAKKRK 815
Query: 395 QNHSQGPLRSMVEDLQSEESDEDDSSSGEEAAGKTNPGRDSRLSFSDSESDNSADSSLPS 454
+ + + +S SSS + + KT P R S+ SS
Sbjct: 816 GEAERDCDNKKIRLEKEIKSQSSSSSSSHKESSKTKPSRP------------SSQSSKKE 863
Query: 455 REPPPP-----QKPPPPNSKVSGRRSPESCSK 481
PPPP QKP P K S RR ++C +
Sbjct: 864 MLPPPPVSSSSQKPAKPALKRS-RREADTCGQ 894
Score = 33.9 bits (76), Expect = 0.40
Identities = 31/145 (21%), Positives = 56/145 (38%), Gaps = 15/145 (10%)
Query: 167 SAFSDPKKTKPSHGSKDANKESSKTSKPHKVTKEHRERPRKDSESKSSSKELEREQAKSS 226
S+ + KTKPS S ++K+ P + + +P S+ + ++ KS+
Sbjct: 842 SSHKESSKTKPSRPSSQSSKKEMLPPPPVSSSSQKPAKPAL-KRSRREADTCGQDPPKSA 900
Query: 227 KDTSRKLGEGRLPKEEKAPPPKAAFKEPKMALKETKLESTSPKGGPPPPPPPPPRASSKR 286
T + +PK+ + E K + ++ + +S P P P P +SK
Sbjct: 901 SSTKSNHKDSSIPKQRRV--------EGKGSRSSSEHKGSSGDTANPFPVPSLPNGNSK- 951
Query: 287 PATADSPKPSAKKQKKSSSKGSRSA 311
KP K K+ + R A
Sbjct: 952 -----PGKPQVKFDKQQADLHMREA 971
>gi|118572613 splicing coactivator subunit SRm300 [Homo sapiens]
Length = 2752
Score = 66.2 bits (160), Expect = 7e-11
Identities = 92/371 (24%), Positives = 133/371 (35%), Gaps = 94/371 (25%)
Query: 162 PTIPLSAFSDPKKTKPSHGSKDANKESSKTSKPHKVTKEHRERPRKDSESKSSSKELERE 221
P +PLSA+ + S +TS P R P S+S+ +S+
Sbjct: 2383 PRVPLSAYE---------------RVSGRTSPPLLDRARSRTPPSAPSQSRMTSERAPSP 2427
Query: 222 QAKSSKDTSRKLGEGRLPKEEKAP--PPKAAFKEPKMALKETKLESTSPKGGPP------ 273
++ + S+ L LP + P P +AF + L + T+P G
Sbjct: 2428 SSRMGQAPSQSL----LPPAQDQPRSPVPSAFSDQSRCL----IAQTTPVAGSQSLSSGA 2479
Query: 274 -----------------PPPPPPPRASSKRPATADSPKPSA------KKQKKSSSKGSRS 310
P P P + PA+ + +PSA K+++SSS S S
Sbjct: 2480 VATTTSSAGDHNGMLSVPAPGVPHSDVGEPPASTGAQQPSALAALQPAKERRSSSSSSSS 2539
Query: 311 APGTSPRTSSSSSFSDKKPAKDKSSTRGEKVKAESE------------PREA-------- 350
+ +S +SSSSS S S + G + + E P+EA
Sbjct: 2540 SSSSS--SSSSSSSSSSSSGSSSSDSEGSSLPVQPEVALKRVPSPTPAPKEAVREGRPPE 2597
Query: 351 ---KKALEVEESNSEDEASFKSESAQSSPSNSSSSSDSSSDSDFEPSQNHSQGPLRSMVE 407
K S+S +S S S+ SS S+SSSSS SSS S S + S P + +
Sbjct: 2598 PTPAKRKRRSSSSSSSSSSSSSSSSSSSSSSSSSSSSSSSSSSSSSSSSSSPSPAKPGPQ 2657
Query: 408 DLQSEESDEDDSSSGEEAAGKTNP---GRDSR-LSFSDSESDNSADSSLPSREPPPPQKP 463
L S + + P RDSR LS+S E R P PQ
Sbjct: 2658 ALPKPASPKKPPPGERRSRSPRKPIDSLRDSRSLSYSPVE-----------RRRPSPQPS 2706
Query: 464 PPPNSKVSGRR 474
P S R
Sbjct: 2707 PRDQQSSSSER 2717
Score = 63.2 bits (152), Expect = 6e-10
Identities = 59/251 (23%), Positives = 91/251 (36%), Gaps = 39/251 (15%)
Query: 273 PPPPPPPPRASSKRPATADSPKPSAKKQKKSSSKGSRSAPGTSPRTSSSSSFSDKK---- 328
P P PP P + + +++ SP P KK+KK +G RS +SPR S KK
Sbjct: 163 PAPEPPKPYSLVRESSSSRSPTPKQKKKKKKKDRGRRS-ESSSPRRERKKSSKKKKHRSE 221
Query: 329 -----------------PAKDKSSTRGEKVKAESEPREAKKALEVEESNSEDEASFKSES 371
+KDK R + R A ++ + ++S D + +S S
Sbjct: 222 SESKKRKHRSPTPKSKRKSKDKKRKRSRSTTPAPKSRRAHRSTSADSASSSDTSRSRSRS 281
Query: 372 AQS----------SPSNSSSSSDSSSDSDFEPSQNHSQGPLRSMVEDLQSEESDED-DSS 420
A + SPS +S EP +Q P Q ED D
Sbjct: 282 AAAKTHTTALAGRSPSPASGRRGEGDAPFSEPGTTSTQRPSSPETATKQPSSPYEDKDKD 341
Query: 421 SGEEAAGKTNPGRDSRLSFSDSE------SDNSADSSLPSREPPPPQKPPPPNSKVSGRR 474
E++A + +P + + + ++ S P P Q+P P S+ S R
Sbjct: 342 KKEKSATRPSPSPERSSTGPEPPAPTPLLAERHGGSPQPLATTPLSQEPVNPPSEASPTR 401
Query: 475 SPESCSKPEKI 485
PEK+
Sbjct: 402 DRSPPKSPEKL 412
Score = 61.6 bits (148), Expect = 2e-09
Identities = 66/348 (18%), Positives = 132/348 (37%), Gaps = 36/348 (10%)
Query: 168 AFSDPKKTKPSHGSKDANKESSKTSKPHKVTKEH-----------RERPRKDSESKSSSK 216
++ D P +++A + + + KP+ + +E +++ +KD +S S
Sbjct: 144 SYVDGSSFDPQRRAREAKQPAPEPPKPYSLVRESSSSRSPTPKQKKKKKKKDRGRRSESS 203
Query: 217 ELEREQAKSSKDTSRKLGEGRLPKEEKAPPPKAAFKEPKMALKETKLESTSPKGGPPPPP 276
RE+ KSSK + ++ ++P PK+ K K + ST+
Sbjct: 204 SPRRERKKSSKKKKHRSESESKKRKHRSPTPKS--KRKSKDKKRKRSRSTT--------- 252
Query: 277 PPPPRASSKRPATADSPKPSAKKQKKSSSKGSR----SAPGTSPRTSSSSSFSDKKPAKD 332
P P + R +ADS S + +S S ++ + G SP +S P +
Sbjct: 253 PAPKSRRAHRSTSADSASSSDTSRSRSRSAAAKTHTTALAGRSPSPASGRRGEGDAPFSE 312
Query: 333 KSSTRGEKVKAESEPREAKKALEVEESNSEDEASFKSESAQSSPSNSSSSSDSSSDSDFE 392
+T ++ P + A + S ED+ K E + + PS S S + +
Sbjct: 313 PGTTSTQR------PSSPETATKQPSSPYEDKDKDKKEKSATRPSPSPERSSTGPEPPAP 366
Query: 393 P---SQNHSQGPLRSMVEDLQSEE-SDEDDSSSGEEAAGKTNPGRDSRLSFSDSESDNSA 448
++ H P L E + ++S + + +P + + S S+S +
Sbjct: 367 TPLLAERHGGSPQPLATTPLSQEPVNPPSEASPTRDRSPPKSPEKLPQSSSSESSPPSPQ 426
Query: 449 DSSLPSREPPPPQKPPPPNSKVSGRRSPESCSKPEKILKKGTYDKAYT 496
+ + P+ P P + S R S + + + DK+++
Sbjct: 427 PTKVSRHASSSPESPKPAPAPGSHREISSSPTSKNRSHGRAKRDKSHS 474
Score = 61.6 bits (148), Expect = 2e-09
Identities = 85/375 (22%), Positives = 126/375 (33%), Gaps = 53/375 (14%)
Query: 146 EGADTVSRPSPDYPMLPTIPLSAFSDPKKTKPSHGSKDANKESSKTSKPHKVTKEHRE-- 203
E A S S P+L +P +T S A+ K P ++ R
Sbjct: 1392 EKAGMSSNQSISSPVLDAVP--------RTPSRERSSSASSPEMKDGLPRTPSRRSRSGS 1443
Query: 204 RPRKDSESKSSSKELEREQAKSSKDTSRKLGEGRLPKEEKAPPPKAAFKEPKMALKETKL 263
P S + S+ + KD R GR + + +P PKA + P+ +
Sbjct: 1444 SPGLRDGSGTPSRHSLSGSSPGMKDIPRTPSRGR-SECDSSPEPKALPQTPRPRSRSPSS 1502
Query: 264 ESTSPKGGPPPPPPPPPRASSKRPATADSP---------------KPSAKKQKKSSSKGS 308
+ K P +S + A +P KPSA Q++S S S
Sbjct: 1503 PELNNKCLTPQRERSGSESSVDQKTVARTPLGQRSRSGSSQELDVKPSASPQERSESDSS 1562
Query: 309 -------------RSAPGTSPRTSSSSSFSDKKPAKDKSSTRGEKVKAESEPREAKKALE 355
RS G+SP S S S ++ S G + + +PR A +A
Sbjct: 1563 PDSKAKTRTPLRQRSRSGSSPEVDSKSRLSPRR------SRSGSSPEVKDKPRAAPRAQS 1616
Query: 356 VEESNSEDEASFKSESAQSSPSNSSSSSDSSSDSDFEPSQNHSQGPLRSMVEDLQSEESD 415
+S+ E +A + S S SSS S +++ + P +S S S
Sbjct: 1617 GSDSSPEPKAPAPRALPRRSRSGSSSKGRGPSPEGSSSTESSPEHPPKSRTARRGSRSSP 1676
Query: 416 EDDSS--------SGEEAAGKTNPGRDSRLSFSDSESDNSADSSLPSREPPPPQKPPPPN 467
E + S + T R SR S S S S + + P P P P
Sbjct: 1677 EPKTKSRTPPRRRSSRSSPELTRKARLSRRSRSASSSPETRSRTPPRHRRSPSVSSPEPA 1736
Query: 468 SKVSGRRSPESCSKP 482
K R S S P
Sbjct: 1737 EKSRSSRRRRSASSP 1751
Score = 60.8 bits (146), Expect = 3e-09
Identities = 57/231 (24%), Positives = 85/231 (36%), Gaps = 19/231 (8%)
Query: 204 RPRKDSESKSSSKELEREQAKSSKDTSRKLGEGRLPKEEKAPPPKAAFKEPKMALKETKL 263
+P K+ S SSS + SS +S G + + +P++ALK
Sbjct: 2525 QPAKERRSSSSSSSSSSSSSSSSSSSSSSSSSGSSSSDSEGSSLPV---QPEVALKRV-- 2579
Query: 264 ESTSPKGGPPPPPPPPPRASSKRPATADSPKPSAKKQKKSSSKGSRSAPGTSPRTSSSSS 323
P P P P RP P P+ +K++ SSS S S+ +S +SSSSS
Sbjct: 2580 --------PSPTPAPKEAVREGRPP---EPTPAKRKRRSSSSSSSSSSSSSSSSSSSSSS 2628
Query: 324 FSDKKPAKDKSSTRGEKVKAESEPREAKKALEVEESNSEDEASFKSESAQSSPSNSSSSS 383
S + SS+ + S + +AL S + + + P +S S
Sbjct: 2629 SSSSSSSSSSSSSSSSSSSSPSPAKPGPQALPKPASPKKPPPGERRSRSPRKPIDSLRDS 2688
Query: 384 DSSSDSDFE---PSQNHSQGPLRSMVEDLQSEESDEDDSSSGEEAAGKTNP 431
S S S E PS S +S + S DS S + P
Sbjct: 2689 RSLSYSPVERRRPSPQPSPRDQQSSSSERGSRRGQRGDSRSPSHKRRRETP 2739
Score = 60.1 bits (144), Expect = 5e-09
Identities = 76/341 (22%), Positives = 117/341 (34%), Gaps = 56/341 (16%)
Query: 189 SKTSKPHKVTKEHRERPRKDSESKSSSKELEREQAKSSKDTSRK--LGEGRLPKEEKAPP 246
S S+ + R R R +S S+ L R S+ R+ G K +
Sbjct: 678 SGRSRSRTPARRGRSRSRTPRRGRSRSRSLVRRGRSHSRTPQRRGRSGSSSERKNKSRTS 737
Query: 247 PKAAFKEPKMALKETKLESTSPKGGPPPPPPPPPRASSKRPATADSPKPSAKKQ-----K 301
+ + +K++++ S + P R S +R + SP P K Q
Sbjct: 738 QRRSRSNSSPEMKKSRISSRRSRSLSSPRSKAKSRLSLRRSLSGSSPCPKQKSQTPPRRS 797
Query: 302 KSSSKGSRSAPGTSPRTSSSSSFSDKKPAKDKSSTRGE----------KVKAESEPREAK 351
+S S ++ T PR S SSS P K KS T KVK+ + PR+
Sbjct: 798 RSGSSQPKAKSRTPPRRSRSSS---SPPPKQKSKTPSRQSHSSSSPHPKVKSGTPPRQGS 854
Query: 352 -------------KALEVEESNSEDEASFKSESAQSSPSNSSSSSDSSSDSDFEPSQNHS 398
+ ES+ + E ++ S S +S SS+ PS++ S
Sbjct: 855 ITSPQANEQSVTPQRRSCFESSPDPELKSRTPSRHSCSGSSPPRVKSSTPPRQSPSRSSS 914
Query: 399 QGPLRSMVEDLQSEESDEDDSSSGEEAAGKTNPGR----------DSRLSFSDSESDNSA 448
P + + S S +T P R +SRL S S +S+
Sbjct: 915 PQPKVKAIISPRQRSHSGSSSPSPSRVTSRTTPRRSRSVSPCSNVESRLLPRYSHSGSSS 974
Query: 449 DSSLPSREPPPPQK-------------PPPPNSKVSGRRSP 476
+ E PP Q PP +SG +SP
Sbjct: 975 PDTKVKPETPPRQSHSGSISPYPKVKAQTPPGPSLSGSKSP 1015
Score = 59.7 bits (143), Expect = 7e-09
Identities = 82/365 (22%), Positives = 130/365 (35%), Gaps = 39/365 (10%)
Query: 145 PEGADTVSRPSPDYPMLPTIPL-----SAFSDPKKTKPSHGSKDANKESSKTSKPHKVTK 199
P+ + S S D + PL S S KPS ++ ++ S K
Sbjct: 1512 PQRERSGSESSVDQKTVARTPLGQRSRSGSSQELDVKPSASPQERSESDSSPDSKAKTRT 1571
Query: 200 EHRER------PRKDSESKSSSKELEREQAKSSKDTSRKLGEGRLPKEEKAPPPKAAFKE 253
R+R P DS+S+ S + + KD R + + +P PKA
Sbjct: 1572 PLRQRSRSGSSPEVDSKSRLSPRRSRSGSSPEVKDKPRAAPRAQ-SGSDSSPEPKAP--A 1628
Query: 254 PKMALKETKLESTSPKGGPPP--------PPPPPPRASSKRPATADSPKPSAKKQKKSSS 305
P+ + ++ S+S GP P P PP++ + R + SP+P K +
Sbjct: 1629 PRALPRRSRSGSSSKGRGPSPEGSSSTESSPEHPPKSRTARRGSRSSPEPKTKSRTPPRR 1688
Query: 306 KGSRSAPGTSPR---TSSSSSFSDKKPAKDKSSTRGEKVKAESEPREAKKALEVEESNSE 362
+ SRS+P + + + S S S + ++ R + + S P A+K+ S
Sbjct: 1689 RSSRSSPELTRKARLSRRSRSASSSPETRSRTPPRHRRSPSVSSPEPAEKSRSSRRRRSA 1748
Query: 363 DEASFKSESAQS-SPSNSSSSSDSSSDSDFEPSQNHSQGPLRSMVEDLQSEESDEDDSSS 421
K+ S + SPS S ++ RS S S S
Sbjct: 1749 SSPRTKTTSRRGRSPSPKPRGLQRSRSRSRREKTRTTRRRDRSGSSQSTSRRRQRSRSRS 1808
Query: 422 GEEAAGKTNPGRDSRLSFSDSESDNSADSSL----PSREPPPPQK------PPPPNSKVS 471
+ G SR S + ++S SS SR PP +K P P +
Sbjct: 1809 RVTRRRRGGSGYHSR---SPARQESSRTSSRRRRGRSRTPPTSRKRSRSRTSPAPWKRSR 1865
Query: 472 GRRSP 476
R SP
Sbjct: 1866 SRASP 1870
Score = 54.7 bits (130), Expect = 2e-07
Identities = 63/313 (20%), Positives = 107/313 (34%), Gaps = 26/313 (8%)
Query: 178 SHGSKDANKESSKTSKPHKVTKEHRERPRKDSESKSSSKELEREQAKSSKDTSRKLGEGR 237
SH A + S++ P + R R R + +S S+ R +++S R R
Sbjct: 562 SHSRSPATRGRSRSRTP---ARRGRSRSRTPARRRSRSRTPTRRRSRSRTPARRGRSRSR 618
Query: 238 LPKEEKAPPPKAAFKEPKMALKETKLESTSPKGGPPPPPPPPPRASSKRPATADSPKPSA 297
P ++ + + ++ S + + G P R S+ S P+
Sbjct: 619 TPARRRS-------RTRSPVRRRSRSRSPARRSGRSRSRTPARRGRSR------SRTPAR 665
Query: 298 KKQKKSSSKGSRSAPGTSPRTSSSSSFSDKKPAKDKSSTRGEKVKAESEPREAKKALEVE 357
+ + +S + RS S + + P + +S +R + S R ++
Sbjct: 666 RGRSRSRTPARRSGRSRSRTPARRGRSRSRTPRRGRSRSRSLVRRGRSHSRTPQR----- 720
Query: 358 ESNSEDEASFKSESAQSSPSNSSSSSDSSSDSDFEPSQNHSQGPLRSMVEDLQSEESDED 417
S + K++S S + S+SS S ++ S RS + S
Sbjct: 721 RGRSGSSSERKNKSRTSQRRSRSNSSPEMKKSRISSRRSRSLSSPRSKAKSRLSLRRSLS 780
Query: 418 DSSSGEEAAGKTNPGRDSRLSFSDSESDNSADSSLPSREPPPPQKPPPPNSKVSGRRSPE 477
SS + +T P R S A S P R PPP + R
Sbjct: 781 GSSPCPKQKSQTPPRRSR-----SGSSQPKAKSRTPPRRSRSSSSPPPKQKSKTPSRQSH 835
Query: 478 SCSKPEKILKKGT 490
S S P +K GT
Sbjct: 836 SSSSPHPKVKSGT 848
Score = 52.8 bits (125), Expect = 8e-07
Identities = 65/309 (21%), Positives = 109/309 (35%), Gaps = 37/309 (11%)
Query: 182 KDANKESSKTSKPHKVTKEHRERPRKDSESKSSSKELEREQAKSSKDTSRKLGEGRLPKE 241
+ ++ ++ + T R R R + ++ S + R A+ + SR GR
Sbjct: 646 RSRSRTPARRGRSRSRTPARRGRSRSRTPARRSGRSRSRTPARRGRSRSRTPRRGRSRSR 705
Query: 242 EKAPPPKAAFKEPKMALKETKLESTSPKGGPPPPPPPPPRASSKRPATADSPKPSAKKQK 301
++ + P+ + K R S +R + SP+ K+
Sbjct: 706 SLVRRGRSHSRTPQRRGRSGSSSERKNKS----------RTSQRRSRSNSSPE---MKKS 752
Query: 302 KSSSKGSRSAPGTSPRTSSSSSFSDKKPAKDKSSTRGEKVKAESEPREAKKALEVEESNS 361
+ SS+ SRS +SPR+ + S S ++ S K K+++ PR ++ ++ S
Sbjct: 753 RISSRRSRSL--SSPRSKAKSRLSLRRSLSGSSPC--PKQKSQTPPRRSRSGSSQPKAKS 808
Query: 362 EDEASFKSESAQSSPSNSSS---SSDSSSDSDFEPSQNHSQGPLRSMVEDLQSEESDEDD 418
+S S+ S P S S S S S P P + + Q+ E
Sbjct: 809 RTPPR-RSRSSSSPPPKQKSKTPSRQSHSSSSPHPKVKSGTPPRQGSITSPQANEQSV-- 865
Query: 419 SSSGEEAAGKTNPGRDSRLSFSDSESDNSADSSLPSREPPPPQKPPPPNSKVSGRRSPES 478
R S +S D S PSR PP S R+SP
Sbjct: 866 --------------TPQRRSCFESSPDPELKSRTPSRHSCSGSSPPRVKSSTPPRQSPSR 911
Query: 479 CSKPEKILK 487
S P+ +K
Sbjct: 912 SSSPQPKVK 920
Score = 50.8 bits (120), Expect = 3e-06
Identities = 80/351 (22%), Positives = 124/351 (35%), Gaps = 29/351 (8%)
Query: 148 ADTVSRPSPDYPM---LPTIPLSAFSDPKKTKPSHGSKDANKESSKTSKPHKVTKEHRER 204
A +P+P+ P L S+ S K K KD + S ++S P + K+ ++
Sbjct: 157 AREAKQPAPEPPKPYSLVRESSSSRSPTPKQKKKKKKKDRGRRS-ESSSPRRERKKSSKK 215
Query: 205 PRKDSESKSSSKELEREQAKS---SKDTSRKLGEGR--LPKEEKAPPPKAAFKEPKMALK 259
+ SES+S ++ KS SKD RK PK +A +A
Sbjct: 216 KKHRSESESKKRKHRSPTPKSKRKSKDKKRKRSRSTTPAPKSRRAHRSTSADSASSSDTS 275
Query: 260 ETKLESTSPKGGPPPPPPPPPRASSKRPATADSPKPSAKKQKKSSSKGSRSAPGTSPRTS 319
++ S + K P +S R D+P + ++S S+P T+ +
Sbjct: 276 RSRSRSAAAKTHTTALAGRSPSPASGRRGEGDAP----FSEPGTTSTQRPSSPETATKQP 331
Query: 320 SSSSFSDKKPAKDKSSTR----GEKVKAESEPREAKKALEVEESNSEDEASFK--SESAQ 373
SS K K+KS+TR E+ EP L S + S+
Sbjct: 332 SSPYEDKDKDKKEKSATRPSPSPERSSTGPEPPAPTPLLAERHGGSPQPLATTPLSQEPV 391
Query: 374 SSPSNSSSSSDSSSDSDFEPSQNHSQGPLRSMVEDLQSEESDEDDSSSGEEAAGKTNPGR 433
+ PS +S + D S P + S Q + SSS E PG
Sbjct: 392 NPPSEASPTRDRSPPK--SPEKLPQSSSSESSPPSPQPTKVSRHASSSPESPKPAPAPGS 449
Query: 434 DSRLSFSDSESDNS--------ADSSLPSREPPPPQKPPPPNSKVSGRRSP 476
+S S + + S + S PSR + P S R+P
Sbjct: 450 HREISSSPTSKNRSHGRAKRDKSHSHTPSRRMGRSRSPATAKRGRSRSRTP 500
Score = 50.8 bits (120), Expect = 3e-06
Identities = 83/386 (21%), Positives = 137/386 (35%), Gaps = 36/386 (9%)
Query: 107 NLEGNPPVNHLRCEKLTFNNPTTEFRYKLLRAGGVMVMPEGADTVSRP--SPDYPMLPTI 164
N E +P V LT + ++ + + +P A + P SP++ L
Sbjct: 1267 NFESSPEVEERPAVSLTLDQSQSQASLEAVE------VPSMASSWGGPHFSPEHKELSNS 1320
Query: 165 PL--SAFSDPKKTKPSHGSKDANKESSKTSKPHKVTKEHRERPRKDSESKSSSKELEREQ 222
PL ++F P + + S G + +S+ KE P + S +++ +
Sbjct: 1321 PLRENSFGSPLEFRNS-GPLGTEMNTGFSSE----VKEDLNGPFLNQLETDPSLDMKEQS 1375
Query: 223 AKSSKDTSRKLGEGRLPKEEKAPPPKAAFKEPKMALKETKLESTSPKGGPPPPPPPPPRA 282
+SS +S +L + K A + +SP P P R+
Sbjct: 1376 TRSSGHSSSELSPDAVEK----------------AGMSSNQSISSPVLDAVPRTPSRERS 1419
Query: 283 SS-KRPATADS-PKPSAKKQKKSSSKGSRSAPGTSPRTSSSSSFSDKKPAKDKSSTRGEK 340
SS P D P+ +++ + SS G R GT R S S S K S +
Sbjct: 1420 SSASSPEMKDGLPRTPSRRSRSGSSPGLRDGSGTPSRHSLSGSSPGMKDIPRTPSRGRSE 1479
Query: 341 VKAESEPREAKKALEVEE-SNSEDEASFKSESAQSSPSNSSSSSDSSSDSDFEPSQNHSQ 399
+ EP+ + S S E + K + Q S S SS D + + Q
Sbjct: 1480 CDSSPEPKALPQTPRPRSRSPSSPELNNKCLTPQRERSGSESSVDQKTVARTPLGQRSRS 1539
Query: 400 GPLRSM--VEDLQSEESDEDDSSSGEEAAGKTNPGRDSRLSFSDSESDNSADSSLPSREP 457
G + + +E E DSS +A +T + SR S S S SR
Sbjct: 1540 GSSQELDVKPSASPQERSESDSSPDSKAKTRTPLRQRSRSGSSPEVDSKSRLSPRRSRSG 1599
Query: 458 PPPQKPPPPNSKVSGRRSPESCSKPE 483
P+ P + + +S +P+
Sbjct: 1600 SSPEVKDKPRAAPRAQSGSDSSPEPK 1625
Score = 50.8 bits (120), Expect = 3e-06
Identities = 44/177 (24%), Positives = 71/177 (40%), Gaps = 17/177 (9%)
Query: 146 EGADTVSRPSPDYPMLPT---IPLSAFSDPKKTKPSHGSKDANKESSKTSKPHKVTKEHR 202
EG+ +P +P+ P A + + +P+ + SS +S +
Sbjct: 2564 EGSSLPVQPEVALKRVPSPTPAPKEAVREGRPPEPTPAKRKRRSSSSSSSSSSSSSSSSS 2623
Query: 203 ERPRKDSESKSSSKELEREQAKSSKDTSRKLGEGRLPK--EEKAPPP----KAAFKEPKM 256
S S SSS + SS + K G LPK K PPP + ++P
Sbjct: 2624 SSSSSSSSSSSSSSSSSSSSSSSSSPSPAKPGPQALPKPASPKKPPPGERRSRSPRKPID 2683
Query: 257 ALKETKLESTSPKGGPPPPPPPPPR--------ASSKRPATADSPKPSAKKQKKSSS 305
+L++++ S SP P P P PR S+R DS PS K+++++ S
Sbjct: 2684 SLRDSRSLSYSPVERRRPSPQPSPRDQQSSSSERGSRRGQRGDSRSPSHKRRRETPS 2740
Score = 50.1 bits (118), Expect = 5e-06
Identities = 76/332 (22%), Positives = 115/332 (34%), Gaps = 58/332 (17%)
Query: 170 SDPKKTKPSHGSKDANKESSKTSKPHKVTKEHRERPRKDSESKSSSKELEREQAKSSKDT 229
S P + S ++ S K T R R K SK R Q+ SS
Sbjct: 782 SSPCPKQKSQTPPRRSRSGSSQPKAKSRTPPRRSRSSSSPPPKQKSKTPSR-QSHSSSSP 840
Query: 230 SRKLGEGRLPKEEKAPPPKA--------------AFKEPKMALKETKLESTSPKGGPPPP 275
K+ G P++ P+A + +P++ + S S P
Sbjct: 841 HPKVKSGTPPRQGSITSPQANEQSVTPQRRSCFESSPDPELKSRTPSRHSCSGSSPPRVK 900
Query: 276 PPPPPRASSKRPATADSPKPSAK-----KQK----KSSSKGSRSAPGTSPRTSSSSSFSD 326
PPR S P+ + SP+P K +Q+ SS SR T+PR S S S
Sbjct: 901 SSTPPRQS---PSRSSSPQPKVKAIISPRQRSHSGSSSPSPSRVTSRTTPRRSRSVSPCS 957
Query: 327 KKPAK-------DKSSTRGEKVKAESEPREAKKALEVEESNSEDEASFKSESAQSSPSNS 379
++ SS+ KVK E+ PR +S+S + + AQ+ P S
Sbjct: 958 NVESRLLPRYSHSGSSSPDTKVKPETPPR---------QSHSGSISPYPKVKAQTPPGPS 1008
Query: 380 SSSSDSSSDSDFEPSQNHSQGPLRSMVEDLQSEESDEDDSSSGEEAAG----------KT 429
S S S P + ++S L + + GE G +T
Sbjct: 1009 LSGSKSPC-----PQEKSKDSLVQSCPGSLSLCAGVKSSTPPGESYFGVSSLQLKGQSQT 1063
Query: 430 NPGRDSRLSFSDSESDNSADSSLPSREPPPPQ 461
+P S S + +S SL S+ P+
Sbjct: 1064 SPDHRSDTSSPEVRQSHSESPSLQSKSQTSPK 1095
Score = 46.2 bits (108), Expect = 8e-05
Identities = 83/362 (22%), Positives = 132/362 (36%), Gaps = 49/362 (13%)
Query: 152 SRPSPDYPM-LPTIPLSAFSDPKKTKPSHGSKDANKESSKTSKPHKVTKEHRERPRKDSE 210
S P P+ P+ + S P + K S + + SS K R+R S
Sbjct: 875 SSPDPELKSRTPSRHSCSGSSPPRVKSSTPPRQSPSRSSSPQPKVKAIISPRQRSHSGSS 934
Query: 211 SKSSSKELEREQAKSSKDTS--RKLGEGRLPKEEKAPPPKAAFK-EPKMALKETKLESTS 267
S S S+ R + S+ S + LP+ + K +P+ +++ S S
Sbjct: 935 SPSPSRVTSRTTPRRSRSVSPCSNVESRLLPRYSHSGSSSPDTKVKPETPPRQSHSGSIS 994
Query: 268 PKGGPPPPPPPPPRAS-SKRPATADSPKPSAKKQ-----------KKSSSKG-------- 307
P PP P S SK P + K S + K S+ G
Sbjct: 995 PYPKVKAQTPPGPSLSGSKSPCPQEKSKDSLVQSCPGSLSLCAGVKSSTPPGESYFGVSS 1054
Query: 308 ------SRSAPG-----TSPRTSSSSSFSDKKPAKDKSSTRGEKVKAESEPREAKKALEV 356
S+++P +SP S S S +K ++S +G + ++ S E +
Sbjct: 1055 LQLKGQSQTSPDHRSDTSSPEVRQSHSESPSLQSKSQTSPKGGRSRSSSPVTELASRSPI 1114
Query: 357 EESNSEDEASFKSESAQSSPSNSSSSSDSSSDSDFEPSQNHSQGPLRSMVEDLQSEESDE 416
+ E AS +S SP S SDSSS + N G R L++ ES E
Sbjct: 1115 RQDRGEFSASPMLKSGM-SPEQSRFQSDSSSYPTVD--SNSLLGQSR-----LETAESKE 1166
Query: 417 DDSSSGEEAAGKTNPGRDSRLSFSDSESDNSADSSLPSREPPPPQKPPPPNSKVSGRRSP 476
+ +E A + P + + FS + +SSL ++ PP + SP
Sbjct: 1167 KMALPPQEDATASPPRQKDK--FSPFPVQDRPESSLVFKD----TLRTPPRERSGAGSSP 1220
Query: 477 ES 478
E+
Sbjct: 1221 ET 1222
Score = 45.1 bits (105), Expect = 2e-04
Identities = 83/382 (21%), Positives = 132/382 (34%), Gaps = 64/382 (16%)
Query: 155 SPDYPMLPTIPLS---AFSDPKKTKPSHGSKDANKESSKT-------SKPHKVTKEHRER 204
SP+ P P S S P SHG +K S T S+ K R R
Sbjct: 437 SPESPKPAPAPGSHREISSSPTSKNRSHGRAKRDKSHSHTPSRRMGRSRSPATAKRGRSR 496
Query: 205 ---PRKDSESKSSSKELEREQAKSSKDTSRKLGEGRLPKEE--KAPPPKAAFKEPKMALK 259
P K S+S S + R ++ +++ G R P+ P + + + +
Sbjct: 497 SRTPTKRGHSRSRSPQWRRSRS------AQRWGRSRSPQRRGRSRSPQRPGWSRSRNTQR 550
Query: 260 ETKLESTSPKGGPPPPPPPPPRASSKRPAT---ADSPKPSAKKQKKSSSKGSRSAPGTSP 316
+ S P R+ S+ PA + S P+ ++ + + RS T
Sbjct: 551 RGRSRSARRGRSHSRSPATRGRSRSRTPARRGRSRSRTPARRRSRSRTPTRRRSRSRTPA 610
Query: 317 RTSSSSSFSDKKPAKDKSSTRG---EKVKAESEPREAKKALEVE---------------- 357
R S S + PA+ +S TR + ++ S R + ++
Sbjct: 611 RRGRSRS---RTPARRRSRTRSPVRRRSRSRSPARRSGRSRSRTPARRGRSRSRTPARRG 667
Query: 358 ESNSEDEASFKSESAQSSPSNSSSSSD-------SSSDSDFEPSQNHSQGPLRSMVEDLQ 410
S S A S +P+ S S S S ++HS+ P R
Sbjct: 668 RSRSRTPARRSGRSRSRTPARRGRSRSRTPRRGRSRSRSLVRRGRSHSRTPQRRGRSGSS 727
Query: 411 SEESDEDDSSSGEEAAGKTNPGRDSRLSFSDSESDNSADSSLPSR----------EPPPP 460
SE ++ +S + + + SR+S S S +S S SR P P
Sbjct: 728 SERKNKSRTSQRRSRSNSSPEMKKSRISSRRSRSLSSPRSKAKSRLSLRRSLSGSSPCPK 787
Query: 461 QK-PPPPNSKVSGRRSPESCSK 481
QK PP SG P++ S+
Sbjct: 788 QKSQTPPRRSRSGSSQPKAKSR 809
Score = 43.9 bits (102), Expect = 4e-04
Identities = 54/262 (20%), Positives = 93/262 (35%), Gaps = 20/262 (7%)
Query: 146 EGADTVSRPSPDYPMLPTIPLSAFSDPKKTKPSHGSKDANKESSKTSKPHKVTKEHRERP 205
EG S P P+ P +A P + KD +K+ ++P ER
Sbjct: 305 EGDAPFSEPGTTSTQRPSSPETATKQPSSP---YEDKDKDKKEKSATRP----SPSPERS 357
Query: 206 RKDSESKSSSKELEREQAKSSKDTSRKLGEGRLPKEEKAPPPKAAFKEPKMALKETKLES 265
E + + L S + L L +E PP +A+ + K +
Sbjct: 358 STGPEPPAPTPLLAERHGGSPQP----LATTPLSQEPVNPPSEASPTRDRSPPKSPEKLP 413
Query: 266 TSPKGGPPPPPPPPPRASSKRPATADSPKPS----AKKQKKSSSKGSRSAPGTSPRTSSS 321
S PP P P + S ++ +SPKP+ + ++ SS + G + R S
Sbjct: 414 QSSSSESSPPSPQPTKVSRHASSSPESPKPAPAPGSHREISSSPTSKNRSHGRAKRDKSH 473
Query: 322 SSFSDKKPAKDKSSTRGEKVKAESEPREAKKALEVEESNSEDEASFKSESAQSSPSNSSS 381
S ++ + +S ++ ++ S + + S S +S SAQ + S
Sbjct: 474 SHTPSRRMGRSRSPATAKRGRSRS-----RTPTKRGHSRSRSPQWRRSRSAQRWGRSRSP 528
Query: 382 SSDSSSDSDFEPSQNHSQGPLR 403
S S P + S+ R
Sbjct: 529 QRRGRSRSPQRPGWSRSRNTQR 550
Score = 41.6 bits (96), Expect = 0.002
Identities = 55/201 (27%), Positives = 70/201 (34%), Gaps = 21/201 (10%)
Query: 266 TSPKGGPPPPPPPPPRASSKRPATADSPKPSAKKQKKSSSKGSRSAPGTSPRTSSSSSFS 325
TSPKGG P +S+ P D + SA KS G SP S S S
Sbjct: 1092 TSPKGGRSRSSSPVTELASRSPIRQDRGEFSASPMLKS---------GMSPEQSRFQSDS 1142
Query: 326 DKKPAKDKSSTRGEKVKAESEPREAKKALEVEE----SNSEDEASFKSESAQSSPSNSSS 381
P D +S G+ +E +E K AL +E S + F Q P +S
Sbjct: 1143 SSYPTVDSNSLLGQSRLETAESKE-KMALPPQEDATASPPRQKDKFSPFPVQDRPESSLV 1201
Query: 382 SSDSSSDSDFEPSQNHSQGPLRSMVEDLQSEESDE---DDSSSGEEAAGKTNPGRDSRLS 438
D+ E S S + L + DE + EE AG+ S LS
Sbjct: 1202 FKDTLRTPPRERSGAGSSPETKEQNSALPTSSQDEELMEVVEKSEEPAGQIL----SHLS 1257
Query: 439 FSDSESDNSADSSLPSREPPP 459
E S S P E P
Sbjct: 1258 SELKEMSTSNFESSPEVEERP 1278
Score = 39.3 bits (90), Expect = 0.010
Identities = 61/323 (18%), Positives = 120/323 (37%), Gaps = 24/323 (7%)
Query: 149 DTVSRPSPDYPMLPTIPLSAFSDPKKTKPSHGSKDANKESSKTSKPHKVTKEHRERPRKD 208
+T SR P + P++ S+ +K++ S + A+ +KT+ + + R +
Sbjct: 1715 ETRSRTPPRHRRSPSV--SSPEPAEKSRSSRRRRSASSPRTKTTSRRGRSPSPKPRGLQR 1772
Query: 209 SESKSSSKELE----REQAKSSKDTSRKLGEGRL-PKEEKAPPPKAAFKEPKMALKETKL 263
S S+S ++ R+++ SS+ TSR+ R + + + + A +E+
Sbjct: 1773 SRSRSRREKTRTTRRRDRSGSSQSTSRRRQRSRSRSRVTRRRRGGSGYHSRSPARQESSR 1832
Query: 264 ESTSPKGGPPPPPPPPPRASSKRPATADSPKPSAKKQKKSSSKGSRSAPGTSPRTSSSSS 323
S+ + G PP S KR + SP P + + SR++P T R+ S +
Sbjct: 1833 TSSRRRRGRSRTPP----TSRKRSRSRTSPAPWKRSR-------SRASPATHRRSRSRTP 1881
Query: 324 FSDKKPAKDKSS------TRGEKVKAESEPREAKKALEVEESNSEDEASFKSESAQSSPS 377
++ ++ ++S +R R + S S + S +P+
Sbjct: 1882 LISRRRSRSRTSPVSRRRSRSRTSVTRRRSRSRASPVSRRRSRSRTPPVTRRRSRSRTPT 1941
Query: 378 NSSSSSDSSSDSDFEPSQNHSQGPLRSMVEDLQSEESDEDDSSSGEEAAGKTNPGRDSRL 437
S + S++ + R S + S + + R S +
Sbjct: 1942 TRRRSRSRTPPVTRRRSRSRTPPVTRRRSRSRTSPITRRRSRSRTSPVTRRRSRSRTSPV 2001
Query: 438 SFSDSESDNSADSSLPSREPPPP 460
+ S S S + SR PP
Sbjct: 2002 TRRRSRSRTSPVTRRRSRSRTPP 2024
Score = 29.6 bits (65), Expect = 7.6
Identities = 37/143 (25%), Positives = 57/143 (39%), Gaps = 15/143 (10%)
Query: 186 KESSKTSKPHKVTKEHRERP--RKDSESKSSSKELEREQAKSSKDTSRKLGEGRLPKEEK 243
+ S+TS + R P R+ S S++S R ++++S T R+ +
Sbjct: 1969 RSRSRTSPITRRRSRSRTSPVTRRRSRSRTSPVTRRRSRSRTSPVTRRR-------SRSR 2021
Query: 244 APPP---KAAFKEPKMALKETKLESTSPKGGPPPPPPPPPR-ASSKRPATADSPKPSAKK 299
PP ++ + P + K ++ S SP PR A KR T P +
Sbjct: 2022 TPPAIRRRSRSRTPLLPRKRSR--SRSPLAIRRRSRSRTPRTARGKRSLTRSPPAIRRRS 2079
Query: 300 QKKSSSKGSRSAPGTSPRTSSSS 322
SSS SRSA + R S S
Sbjct: 2080 ASGSSSDRSRSATPPATRNHSGS 2102
Score = 29.6 bits (65), Expect = 7.6
Identities = 28/124 (22%), Positives = 47/124 (37%), Gaps = 4/124 (3%)
Query: 167 SAFSDPKKTKPSHGSKDANKESSKTSKPHKVTKEHRERPRKD--SESKSSSKELEREQAK 224
S+ S + S S ++ S +KP P+K E +S S + +
Sbjct: 2627 SSSSSSSSSSSSSSSSSSSSSSPSPAKPGPQALPKPASPKKPPPGERRSRSPRKPIDSLR 2686
Query: 225 SSKDTSRKLGEGRLPKEEKAPPPKAAFKEPKMALKETKLESTSP--KGGPPPPPPPPPRA 282
S+ S E R P + +P + + + + + + +S SP K P P P R
Sbjct: 2687 DSRSLSYSPVERRRPSPQPSPRDQQSSSSERGSRRGQRGDSRSPSHKRRRETPSPRPMRH 2746
Query: 283 SSKR 286
S R
Sbjct: 2747 RSSR 2750
>gi|31377595 zinc finger CCCH-type containing 18 [Homo sapiens]
Length = 953
Score = 65.9 bits (159), Expect = 1e-10
Identities = 76/348 (21%), Positives = 127/348 (36%), Gaps = 34/348 (9%)
Query: 173 KKTKPSHGSKDANKESSKTSKPHKVTKEHRERPRKDSESKSSSKELEREQAKSSKDTSRK 232
+KT S S + SS S + + R R R S S SS+ S+ SR
Sbjct: 542 RKTSASSASASNSSRSSSRSSSYSGSGSSRSRSRSSSYSSYSSRSSRHSSFSGSRSRSRS 601
Query: 233 LGEGRLPKEEKAPPPKAAFKEPKMALKETKLESTSPKGGPPPPPPPPPRASSKRPATADS 292
P +P + + + A K S K PPP PP TA
Sbjct: 602 FSSSPSPSPTPSPHRPSIRTKGEPAPPPGKAGEKSVKKPAPPPAPP-----QATKTTAPV 656
Query: 293 PKPSAKKQKKSSSKGSRSAPGTSPRTSSSSSFSDKKPAKDKSSTRGEKVKAESEPREAKK 352
P+P+ + + + R A R + S S S + SS+R + S +
Sbjct: 657 PEPTKPGDPREARRKERPARTPPRRRTLSGSGSGSGSSYSGSSSRSRSLSVSSVSSVSSA 716
Query: 353 ALEVEESNSEDEASFKSESAQSSPSNSSSSSDSSSDSDFEPSQNHSQGPLRSMVEDLQSE 412
++S D ++ A S S++SS S + + + E ++ + ++ E + +
Sbjct: 717 TSSSSSAHSVDSEDMYADLA-SPVSSASSRSPAPAQTRKEKGKSKKEDGVKE--EKRKRD 773
Query: 413 ESDEDDSSSGEEAAGKTN----------PGRDSRLSF--------------SDSESDNSA 448
S + S+ A GK++ PG+ + +F +D S
Sbjct: 774 SSTQPPKSAKPPAGGKSSQQPSTPQQAPPGQPQQGTFVAHKEIKLTLLNKAADKGSRKRY 833
Query: 449 DSSLPSREPPPPQKPP--PPNSKVSGRRSPESCSKPEKILKKGTYDKA 494
+ S R+ PPP K P P+ R+S P+ ++G KA
Sbjct: 834 EPSDKDRQSPPPAKRPNTSPDRGSRDRKSGGRLGSPKPERQRGQNSKA 881
Score = 60.5 bits (145), Expect = 4e-09
Identities = 67/312 (21%), Positives = 116/312 (37%), Gaps = 36/312 (11%)
Query: 174 KTKPSHGSKDANKESSKTSKPHKVTKEHRERPRKDSESKSSSKELEREQAKSSKDTSRKL 233
+T+P H ++ +E + ++ + +E ++ + +E E E+ K + +
Sbjct: 394 ETEPYHNYRERERERERENRQRERERERERDRERERRQREREREREHERDKERQRRKEEW 453
Query: 234 GEGRLPKEEKAPPPKAAFKEPKMALKETKLESTSPKGGPPPPP-----PPPPRASSKRPA 288
R ++EK + +E KE + E PK P PP PP A++ P
Sbjct: 454 ERERAKRDEKDRQHRDRDRE-----KEREKEKGKPKPRSPQPPSRQAEPPKKEAATTGPQ 508
Query: 289 T--ADSPKPSAKKQKKSSSK-GSRSAPGTSPRTSSSSSFSDKKPAKDKSSTRGEKVKAES 345
AD K ++ K K G +P + R +S+ S +SS+R
Sbjct: 509 VKRADEWKDPWRRSKSPKKKLGVSVSPSRARRRRKTSASSASASNSSRSSSRSSSYSGSG 568
Query: 346 EPREAKKALEVEESNSEDEASFKSESAQSSPSNSSSSSDSSSDS-DFEPSQNHSQGPLRS 404
R ++ +S+ S S++SS +S S S S S S PS + + P R
Sbjct: 569 SSRSRSRS-----------SSYSSYSSRSSRHSSFSGSRSRSRSFSSSPSPSPTPSPHRP 617
Query: 405 MVEDLQSEESDEDDSSSGEEAAGKTNPGRDSRLSFSDSESDNSADSSLPSREPPPPQKPP 464
+ E +GE++ K P + ++ P EP P P
Sbjct: 618 SIR--TKGEPAPPPGKAGEKSVKKPAP---------PPAPPQATKTTAPVPEPTKPGDPR 666
Query: 465 PPNSKVSGRRSP 476
K R+P
Sbjct: 667 EARRKERPARTP 678
Score = 50.4 bits (119), Expect = 4e-06
Identities = 65/294 (22%), Positives = 102/294 (34%), Gaps = 56/294 (19%)
Query: 147 GADTVSRPSPDYPMLPTIPLSAFSDPKKTKPSHGSKDANKESSKTSKPHKVTKEHRERPR 206
G +V +P+P P P + P+ TKP + KE + P + T
Sbjct: 633 GEKSVKKPAPP-PAPPQATKTTAPVPEPTKPGDPREARRKERPARTPPRRRTLSGSGSGS 691
Query: 207 KDSESKSSSKELERE--------QAKSSKDTSRKLGEGRLPKEEKAPPPKAAFKEPKMA- 257
S S SSS+ A SS ++ + + + +P A+ + P A
Sbjct: 692 GSSYSGSSSRSRSLSVSSVSSVSSATSSSSSAHSVDSEDMYADLASPVSSASSRSPAPAQ 751
Query: 258 -------------LKETKLESTSPKGGPPPPPPPPPRASSKRPATADSPKPSAKKQ---- 300
+KE K + S P PP SS++P+T P +Q
Sbjct: 752 TRKEKGKSKKEDGVKEEKRKRDSSTQPPKSAKPPAGGKSSQQPSTPQQAPPGQPQQGTFV 811
Query: 301 ----------KKSSSKGSRSA------------PGTSPRTSSSSSFSDKKPAKDKSS--- 335
K++ KGSR P P TS D+K S
Sbjct: 812 AHKEIKLTLLNKAADKGSRKRYEPSDKDRQSPPPAKRPNTSPDRGSRDRKSGGRLGSPKP 871
Query: 336 --TRGEKVKAESEPREAKKALEVEESNSEDEASFKSESAQSSPSNSSSSSDSSS 387
RG+ KA + P + K+ L + +S S ++ S P +S+ S +S
Sbjct: 872 ERQRGQNSKAPAAPADRKRQLSPQSKSSSKVTSVPGKA--SDPGAASTKSGKAS 923
Score = 39.7 bits (91), Expect = 0.007
Identities = 42/187 (22%), Positives = 71/187 (37%), Gaps = 13/187 (6%)
Query: 167 SAFSDPKKTKPSHGSKDANKESSKTSKPHKVTKEHRERPRKDSESKSSSKELEREQAKSS 226
S+ PK KP G K + + S+ P ++ K+ + +K ++ K
Sbjct: 774 SSTQPPKSAKPPAGGKSSQQPSTPQQAPPGQPQQGTFVAHKEIKLTLLNKAADKGSRKRY 833
Query: 227 KDTSRKLGEGRLPKEEKAPPPKAAFKEPKMALKETKLESTSPKGGPPPPPPPPPRASSKR 286
+ + K+ ++PPP K P + + S P P +SK
Sbjct: 834 EPSD---------KDRQSPPPA---KRPNTSPDRGSRDRKSGGRLGSPKPERQRGQNSKA 881
Query: 287 PATADSPKPSAKKQKKSSSKGSRSAPGTSPRTSSSSSFSDKKPAKDKSSTRGEKVKAESE 346
PA K Q KSSSK S PG + ++S+ S K + +++KA +
Sbjct: 882 PAAPADRKRQLSPQSKSSSK-VTSVPGKASDPGAASTKSGKASTLSRREELLKQLKAVED 940
Query: 347 PREAKKA 353
K+A
Sbjct: 941 AIARKRA 947
Score = 32.7 bits (73), Expect = 0.90
Identities = 28/130 (21%), Positives = 50/130 (38%), Gaps = 8/130 (6%)
Query: 356 VEESNSEDEASFKSESAQSSPSNSSSSSDSSSDSDFEPSQNH----SQGPLRSMVEDLQS 411
V S+ EDE S +Q N S D +S+ + + S+GP S E+
Sbjct: 43 VRASDLEDEESAARGPSQEEEDNHSDEEDRASEPKSQDQDSEVNELSRGPTSSPCEEEGD 102
Query: 412 EESDEDDSSSGEEAAGKTNPGRDSRLSFSDSESDNSADSSLPSREPPPPQKPPPPNSKVS 471
E ++ S +EA+ T + L + + + A P+ + +K + +
Sbjct: 103 EGEEDRTSDLRDEASSVTRELDEHELDYDEEVPEEPA----PAVQEDEAEKAGAEDDEEK 158
Query: 472 GRRSPESCSK 481
G +P K
Sbjct: 159 GEGTPREEGK 168
Score = 31.6 bits (70), Expect = 2.0
Identities = 34/145 (23%), Positives = 51/145 (35%), Gaps = 8/145 (5%)
Query: 354 LEVEESNSEDEASFKSESAQSSPSNSSSSSDSSSDSDFEPSQNHSQGPLRSMVEDLQSEE 413
++V ES D S + E S+ DS SD D + + + DL+ EE
Sbjct: 1 MDVAESPERDPHSPEDEEQPQGLSDDDILRDSGSDQDLDGAGVRAS--------DLEDEE 52
Query: 414 SDEDDSSSGEEAAGKTNPGRDSRLSFSDSESDNSADSSLPSREPPPPQKPPPPNSKVSGR 473
S S EE R S D +S+ + S P+ P + + S
Sbjct: 53 SAARGPSQEEEDNHSDEEDRASEPKSQDQDSEVNELSRGPTSSPCEEEGDEGEEDRTSDL 112
Query: 474 RSPESCSKPEKILKKGTYDKAYTDE 498
R S E + YD+ +E
Sbjct: 113 RDEASSVTRELDEHELDYDEEVPEE 137
>gi|148763347 cell division cycle 2-like 2 isoform 1 [Homo sapiens]
Length = 780
Score = 65.1 bits (157), Expect = 2e-10
Identities = 89/377 (23%), Positives = 144/377 (38%), Gaps = 55/377 (14%)
Query: 173 KKTKPSHGSKDANKE-------SSKTSKPHKVT-KEHRERPRKDSESKSSSKELER---- 220
+K K H + KE S++ K +V +EH R R E + +E ER
Sbjct: 93 RKEKVHHRKDEKRKEKCRHHSHSAEGGKHARVKEREHERRKRHREEQDKARREWERQKRR 152
Query: 221 --------------EQAKSSKDTSRKLGEGRLPKEEKAPPPKAAFKEPK--------MAL 258
EQ + ++ RK+ E + + E+ + A + K A
Sbjct: 153 EMAREHSRRERDRLEQLERKRERERKMREQQKEQREQKERERRAEERRKEREARREVSAH 212
Query: 259 KETKLESTSPKGGPPPPPPPPPRASSKRPATADSPKP--SAKKQKKSSSKGSRSAPGTSP 316
T E S K PPR +R D KP K +++ + +
Sbjct: 213 HRTMREDYSDKVKASHWSRSPPRPPRERFELGDGRKPVKEEKMEERDLLSDLQDISDSER 272
Query: 317 RTSSSSSFSDKKPAKDKSSTRGEKVKAESEPREAKKALEVEESNSEDEASFKSESAQSSP 376
+TSS+ S S A+ S + E+ + E E E + E EE E+E + + S
Sbjct: 273 KTSSAESSS----AESGSGSEEEEEEEEEEEEEGSTSEESEEEEEEEEEEEEETGSNSEE 328
Query: 377 SNSSSSSDSSSDSDFEPSQNHSQGPLRSMVEDLQSEESDEDDSSSGEEAAGKTNPGRDSR 436
++ S+ + S + E + ++ L + E +S E S EE G+ P + S
Sbjct: 329 ASEQSAEEVSEEEMSEDEERENENHLLVVPESRFDRDSGE--SEEAEEEVGEGTP-QSSA 385
Query: 437 LSFSDSESDNSADSSLPSREPPPPQKPPPPNSKVSGRRSPESCSKPEKILKKGTYDKAY- 495
L+ D D+ A + ++ P P + G RS E +I ++GTY Y
Sbjct: 386 LTEGDYVPDSPALLPIELKQELPKYLP-----ALQGCRSVEEFQCLNRI-EEGTYGVVYR 439
Query: 496 -----TDELVELHRRLM 507
TDE+V L R M
Sbjct: 440 AKDKKTDEIVALKRLKM 456
>gi|169218320 PREDICTED: similar to BCL2-associated transcription
factor 1 isoform 2 [Homo sapiens]
Length = 869
Score = 65.1 bits (157), Expect = 2e-10
Identities = 89/353 (25%), Positives = 136/353 (38%), Gaps = 51/353 (14%)
Query: 178 SHGSKDANKESSKT---SKPHKVTKEHRERPRKDSESKSSSKELEREQAKSSKDTSRKL- 233
SH S+ ++ S + S+ H K +R R R S S+S + R+ + ++
Sbjct: 8 SHSSRSKSRSQSSSRSRSRSHSRKKRYRSRSRTYSRSRSRDRMYSRDYRRDYRNNRAMRR 67
Query: 234 -----GEGRLPKEEKAPPPKAAFKEPKMALKETKLESTSPKGGPPPPPPPPPRASSKRPA 288
G GR + P + S SP+ G R+ S+ P
Sbjct: 68 PYGYRGRGRGYYQGGGGRYHRGGYRPVW----NRRHSRSPRRG---------RSRSRSPK 114
Query: 289 TADSPKPSAKKQKKSSSKGSRSAPGTSPRTSSSSSFSDKKPAKDKSSTRGEKVKAESEPR 348
++ + + S + SRS +S R SSS +S +K + S + KAE EP+
Sbjct: 115 RRSVSSQRSRSRSRRSYRSSRSPRSSSSR--SSSPYSKSPVSKRRGSQEKQTKKAEGEPQ 172
Query: 349 -----------EAKKALEVEESNSEDEASFKSESA------QSSPSNSSSSSDSSSDSDF 391
E K E + S S DE + S ++ S+ NS S S S
Sbjct: 173 EESPLKSKSQEEPKDTFEHDPSESIDEFNKSSATSGDIWPGLSAYDNSPRSPHSPSPIAT 232
Query: 392 EPSQNH--SQGPLRSMVEDLQSEESDEDDSSSGEEAAGKTNPGRDSRLSFSDSESDNSAD 449
PSQ+ S P+ S V ++ S S S + + ++ G S S S NS
Sbjct: 233 PPSQSSSCSDAPMLSTVHSAKNTPSQH--SHSIQHSPERSGSGSVGNGSSRYSPSQNSPI 290
Query: 450 SSLPSREPP----PPQKPPPPNSKVSGRRSPESCSKPEKILKKGTYDKAYTDE 498
+PSR P PQ P S+ GR S ++ K G + K +TDE
Sbjct: 291 HHIPSRRSPAKTIAPQNAPRDESR--GRSSFYPDGGDQETAKTGKFLKRFTDE 341
Score = 47.8 bits (112), Expect = 3e-05
Identities = 58/264 (21%), Positives = 92/264 (34%), Gaps = 35/264 (13%)
Query: 199 KEHRERPRKDSESKSSSKELEREQAKSSKDTSRKLGEGRLPKEEKAPPPKAAFKEPKMAL 258
+ H PR+ S K +S + R R P+ + K P
Sbjct: 97 RRHSRSPRRGRSRSRSPKRRSVSSQRSRSRSRRSYRSSRSPRSSSSRSSSPYSKSPVSKR 156
Query: 259 KETKLESTSPKGGPPPPPPPPPRASSKRPATA--DSPKPSAKKQKKSSSKGSRSAPG--- 313
+ ++ + T G P P S + P P S + KSS+ PG
Sbjct: 157 RGSQEKQTKKAEGEPQEESPLKSKSQEEPKDTFEHDPSESIDEFNKSSATSGDIWPGLSA 216
Query: 314 --TSPRTSSSSSFSDKKPAKDKSSTRGEKVKAESEPREAKKALEVEESNSEDEASFKSES 371
SPR+ S S P++ S + + ++++ S S S
Sbjct: 217 YDNSPRSPHSPSPIATPPSQSSSCSDAPMLST--------------VHSAKNTPSQHSHS 262
Query: 372 AQSSPSNSSSSSDSSSDSDFEPSQN---HSQGPLRSMVEDLQSEESDEDDS--------S 420
Q SP S S S + S + PSQN H RS + + + + D+S
Sbjct: 263 IQHSPERSGSGSVGNGSSRYSPSQNSPIHHIPSRRSPAKTIAPQNAPRDESRGRSSFYPD 322
Query: 421 SGEEAAGKTNPGRDSRLSFSDSES 444
G++ KT G+ + F+D ES
Sbjct: 323 GGDQETAKT--GKFLK-RFTDEES 343
Score = 38.1 bits (87), Expect = 0.021
Identities = 59/311 (18%), Positives = 106/311 (34%), Gaps = 42/311 (13%)
Query: 172 PKKTKPSHGSKDANKESSKTSKPHKVTKEHRERPRKDSESKSSS----KELEREQAKSSK 227
P++ + S SS+ S+ R + S S+SSS + + + K
Sbjct: 103 PRRGRSRSRSPKRRSVSSQRSRSRSRRSYRSSRSPRSSSSRSSSPYSKSPVSKRRGSQEK 162
Query: 228 DTSRKLGEGRLPKEEKAPPPKAAFKEPKMALKETKLES---------------------- 265
T + GE +E++P + +EPK + ES
Sbjct: 163 QTKKAEGE----PQEESPLKSKSQEEPKDTFEHDPSESIDEFNKSSATSGDIWPGLSAYD 218
Query: 266 TSPKG--GPPPPPPPPPRASSKRPATADSPKPSAKKQKKSSSKGSRSAPGTSPRTSSSSS 323
SP+ P P PP ++SS A S SAK S + +P S S +
Sbjct: 219 NSPRSPHSPSPIATPPSQSSSCSDAPMLSTVHSAKNTPSQHSHSIQHSPERSGSGSVGNG 278
Query: 324 FSDKKPAKDKSSTRGEKVKAESEPREAKKALEVEESNSEDEASFKSESAQSSPSNSSSSS 383
S P+++ + + P + S +SF + + +
Sbjct: 279 SSRYSPSQNSPI---HHIPSRRSPAKTIAPQNAPRDESRGRSSFYPDGGDQETAKTGKFL 335
Query: 384 DSSSDSDFEPSQNHSQGPLRSMVEDLQSEESDEDDSSSGE----EAAGKTNPGRDSRLSF 439
+D E S+ + ++ E+ E + GE EA + + F
Sbjct: 336 KRFTD---EESRVFLLDRGNTRDKEASKEKGSEKGRAEGEWEDQEALDYFSDKESGKQKF 392
Query: 440 SDSESDNSADS 450
+DSE D++ ++
Sbjct: 393 NDSEGDDTEET 403
Score = 35.4 bits (80), Expect = 0.14
Identities = 68/320 (21%), Positives = 114/320 (35%), Gaps = 47/320 (14%)
Query: 183 DANKESSKTSKPHKVTKEHRERPRKDSESKSSSKELER-EQAKSSK-----DTSRKLGEG 236
D +KE+ + TK+ + K+SE + KE + EQ KS K D S L +
Sbjct: 457 DKHKETGYVVERPSTTKDKHKEEDKNSERITVKKETQSPEQVKSEKLKDLFDYSPPLHKN 516
Query: 237 RLPKEEKAPPPKAAFKEPKMALKETKLESTSPKGGPPPPPPPPPRASSKRPATADSPKPS 296
+E K+ F+E + L+ + S S + P P S RPA+ +
Sbjct: 517 LDARE------KSTFRE-ESPLRIKMIASDSHRPEVKLKMAPVPLDDSNRPASLTKDRLL 569
Query: 297 A--------KKQKKSSSKGSRSAPGTSPRTSSS-------------------------SS 323
A K+Q+ S P S TS S
Sbjct: 570 ASTLVHSVKKEQEFRSIFDHIKLPQASKSTSESFIQHIVSLVHHVKEQYFKSAAMTLSER 629
Query: 324 FSDKKPAKDKSSTRGEKVKAESEPREAKKALEVEESNSEDEASFKSESAQSSPSNSSSSS 383
F+ + A ++ STR + + + L + + +E FK E+ + S+
Sbjct: 630 FTSYQKATEEHSTRQKSPEIHRRIDISPSTLRKDTRLAGEERVFKEENQKGDKKLRCDSA 689
Query: 384 DSSSDSDF-EPSQNHSQGPLRSMVEDLQSEESDEDDSSSGEEAAGKTNPGRDSRLSFSDS 442
D D D ++ +G + E S + ++ E + K + S S
Sbjct: 690 DLRHDIDHRRKERSKERGDSKGSRESRGSRKQEKTPKDYKEYKSYKDDSKHKREQDHSLS 749
Query: 443 ESDNSADSSLPSREPPPPQK 462
S +++ SS SRE +K
Sbjct: 750 SSSSASPSSPSSREEKESKK 769
Score = 34.3 bits (77), Expect = 0.31
Identities = 80/397 (20%), Positives = 134/397 (33%), Gaps = 42/397 (10%)
Query: 152 SRPSPDYPMLPTIPLSAFSDPKKTKPSHGS-KDANKESSKTSKPHKVTKEHRERPRKDSE 210
SR S Y P + S K+TK + G ++ + SK+ + K T EH D
Sbjct: 142 SRSSSPYSKSP-VSKRRGSQEKQTKKAEGEPQEESPLKSKSQEEPKDTFEHDPSESIDEF 200
Query: 211 SKSSSKELEREQAKSSKDTSRKLGEGRLPKEEKAPPPKAAFKEPKMALKETKLESTSPKG 270
+KSS+ + S+ D S + P PP +++ L +P
Sbjct: 201 NKSSATSGDIWPGLSAYDNSPR--SPHSPSPIATPPSQSSSCSDAPMLSTVHSAKNTPSQ 258
Query: 271 GPPPPPPPPPRASSKRPATADSPKPSAKKQKKSSSKGSRS-----APGTSPRTSS--SSS 323
P R+ S S ++ RS AP +PR S SS
Sbjct: 259 HSHSIQHSPERSGSGSVGNGSSRYSPSQNSPIHHIPSRRSPAKTIAPQNAPRDESRGRSS 318
Query: 324 F----SDKKPAK------------------DKSSTRGEKVKAESEPREAKKALEVEESNS 361
F D++ AK D+ +TR ++ E + + E E+ +
Sbjct: 319 FYPDGGDQETAKTGKFLKRFTDEESRVFLLDRGNTRDKEASKEKGSEKGRAEGEWEDQEA 378
Query: 362 EDEASFKSESAQSSPSNSSSSSDSSSDSDFEPSQNHSQGPLRSMVEDLQSEESDEDDSSS 421
D S K Q N S D+ D+ + ++E+
Sbjct: 379 LDYFSDKESGKQK--FNDSEGDDTEETEDYRQFRKSVLADQGKSFATASHRNTEEEGLKY 436
Query: 422 GEEAAGKTNPGRDSRLSFSDSESDNSADSSLPSREPPPPQKPPPPNSKVSGRRS-PESCS 480
+ + K N D F + ++D ++ P + K S R + +
Sbjct: 437 KSKVSLKGNRESD---GFREEKNDKHKETGYVVERPSTTKDKHKEEDKNSERITVKKETQ 493
Query: 481 KPEKILKKGTYDKAYTDELVELHRRLMALRERNVLQQ 517
PE++ K K D LH+ L A RE++ ++
Sbjct: 494 SPEQV--KSEKLKDLFDYSPPLHKNLDA-REKSTFRE 527
>gi|7661950 SH2 domain binding protein 1 [Homo sapiens]
Length = 1173
Score = 65.1 bits (157), Expect = 2e-10
Identities = 69/296 (23%), Positives = 115/296 (38%), Gaps = 23/296 (7%)
Query: 180 GSKDANKESSKTSKPHKVTKEHRERPRKDSESKSSSKELEREQAKSSKDTSRKLGEGRLP 239
G +A KE + + +K+ E ++ + +++ + S + GE
Sbjct: 893 GETEATKEKKRGGGGGRRSKKGGEFDEFVNDDTDDDLPISKKKKRRKGSGSEQEGEDEEG 952
Query: 240 KEEKAPPPKAAFKEPKMALKETKLESTSPKGGPPPPPPPPPRASSKRPATADSPKPSAKK 299
E K K + PK E + + GP P PP+A K+ + PS K
Sbjct: 953 GERKK---KKRRRHPK---GEEGSDDDETENGPKPKKRRPPKAEKKKAPKPERLPPSMKG 1006
Query: 300 QKKSSSKGSRSAPGTSPRTSSSSSFSDKKPAKDKSSTRGEKVKAESEPREAKKALEVEES 359
+ KS + S +S SS DK D+ R ++S+ E +K ES
Sbjct: 1007 KIKSKAIIS---------SSDDSSDEDKLKIADEGHPRNSNSNSDSDEDEQRKKCASSES 1057
Query: 360 NSEDEASFKSESAQSSPSNSSSSSDSSSDSDFEPSQNHSQGPLRSMVEDLQSEESDEDDS 419
+S++ + A S SD SDSD +PS+ + P S D +S +S S
Sbjct: 1058 DSDENQNKSGSEAGSPRRPRRQRSDQDSDSD-QPSR--KRRPSGSEQSDNESVQSGRSHS 1114
Query: 420 SSGEEAAGKTNPGRDSRLSFSDSESDNSADSSLPSREPPPPQKPPPPNSKVSGRRS 475
E + +P + SD ES+ +D+ + +P N++ S R S
Sbjct: 1115 GVSENDSRPASPSAE-----SDHESERGSDNEGSGQGSGNESEPEGSNNEASDRGS 1165
Score = 59.3 bits (142), Expect = 9e-09
Identities = 63/300 (21%), Positives = 105/300 (35%), Gaps = 26/300 (8%)
Query: 184 ANKESSKTSKPHKVTKEHRERPRKDSESKSSSKELEREQAKSSKDTSRKLGEGRLPKEEK 243
A +E K K+ KE E+ ++ E + E + + +K+ GE KE+K
Sbjct: 843 AKQEQEKELLRQKLLKEQEEKRLREKEEQKKLLEQRAQYVEKTKNILMFTGETEATKEKK 902
Query: 244 APPPKAAFKEPKMALKETKLESTSPKGGPPPPPPPPPRASSKRPATADSPKPSAKKQKKS 303
+ K + + + P R S + + +K+KK
Sbjct: 903 RGG--GGGRRSKKGGEFDEFVNDDTDDDLPISKKKKRRKGSGSEQEGEDEEGGERKKKKR 960
Query: 304 SSKGSRSAPGTSPRTSSSSSFSDKKP--AKDKSSTRGEKVKAESEPREAKKALEVEESNS 361
T + ++P A+ K + + E++ + + KA+ +S
Sbjct: 961 RRHPKGEEGSDDDETENGPKPKKRRPPKAEKKKAPKPERLPPSMKGKIKSKAIISSSDDS 1020
Query: 362 EDEASFKSESAQSSPSNSSSSSDSSSDSDFEPSQNHSQGPLRSMVEDLQSEESDEDDSSS 421
DE K + P NS+S+SDS D + + +SDE+ + S
Sbjct: 1021 SDEDKLKIAD-EGHPRNSNSNSDSDEDEQRKKCAS-------------SESDSDENQNKS 1066
Query: 422 GEEAAGKTNPGRDSRLSFSDSESDNSADSSLPSREPPPPQKPPPPNSKVSGRRSPESCSK 481
G EA P R SD +DS PSR+ P N V RS S+
Sbjct: 1067 GSEAGSPRRPRRQ--------RSDQDSDSDQPSRKRRPSGSEQSDNESVQSGRSHSGVSE 1118
Score = 56.6 bits (135), Expect = 6e-08
Identities = 70/260 (26%), Positives = 110/260 (42%), Gaps = 31/260 (11%)
Query: 202 RERPRKDSESKSSSKELEREQAKSSKDTSRKLGEGRLPKEEKAPPPKAAFKEPKMALKET 261
+++ RK S S+ ++ E + K K GE +E PK + P A K
Sbjct: 934 KKKRRKGSGSEQEGEDEEGGERKKKKRRRHPKGEEGSDDDETENGPKPKKRRPPKAEK-- 991
Query: 262 KLESTSPKGGPPPPP-PPPPRASSKRPATADSPKPSAKKQK-KSSSKGSRSAPGTSPRTS 319
K P P PP + K A S S+ + K K + +G PR S
Sbjct: 992 -------KKAPKPERLPPSMKGKIKSKAIISSSDDSSDEDKLKIADEG-------HPRNS 1037
Query: 320 SSSSFSD-----KKPAKDKSSTRGEKVKAESE---PREAKKALEVEESNSEDEASFKSES 371
+S+S SD KK A +S + + K+ SE PR ++ ++S+S D+ S K
Sbjct: 1038 NSNSDSDEDEQRKKCASSESDSDENQNKSGSEAGSPRRPRRQRSDQDSDS-DQPSRKRRP 1096
Query: 372 AQSSPSNSSSSSDSSSDSDFEPSQNHSQGPLRSMVEDLQSEESDEDDSSSGEEAAGKTNP 431
+ S S++ S S S S+N S+ S D +SE D+ SG+ + ++ P
Sbjct: 1097 SGSEQSDNESVQSGRSHSGV--SENDSRPASPSAESDHESERG-SDNEGSGQGSGNESEP 1153
Query: 432 GRDSRLSFSDSESDNSADSS 451
S SD S++ +D S
Sbjct: 1154 -EGSNNEASDRGSEHGSDDS 1172
Score = 47.8 bits (112), Expect = 3e-05
Identities = 49/212 (23%), Positives = 86/212 (40%), Gaps = 7/212 (3%)
Query: 172 PKKTKPSHGSKDANKESSKTSKPHKVTKEHRERPRK---DSESKSSSKELEREQAKSSKD 228
PK + S + N K +P K K+ +P + + K SK + SS +
Sbjct: 964 PKGEEGSDDDETENGPKPKKRRPPKAEKKKAPKPERLPPSMKGKIKSKAIISSSDDSSDE 1023
Query: 229 TSRKLGEGRLPKEEKAPPPKAAFKE-PKMALKETKLESTSPKGGPPPPPPPPPRASSKRP 287
K+ + P+ + ++ K A E+ + K G P PR +
Sbjct: 1024 DKLKIADEGHPRNSNSNSDSDEDEQRKKCASSESDSDENQNKSGSEAGSPRRPRRQ-RSD 1082
Query: 288 ATADSPKPSAKKQKKSSSKGSRSAPGTSPRTSSSSSFSDKKPAKDKSSTRGEKVK-AESE 346
+DS +PS +K++ S S+ S + S R+ S S +D +PA + + E + +++E
Sbjct: 1083 QDSDSDQPS-RKRRPSGSEQSDNESVQSGRSHSGVSENDSRPASPSAESDHESERGSDNE 1141
Query: 347 PREAKKALEVEESNSEDEASFKSESAQSSPSN 378
E E S +EAS + S S+
Sbjct: 1142 GSGQGSGNESEPEGSNNEASDRGSEHGSDDSD 1173
>gi|48255931 hepatoma-derived growth factor-related protein 2
isoform 1 [Homo sapiens]
Length = 671
Score = 65.1 bits (157), Expect = 2e-10
Identities = 69/262 (26%), Positives = 104/262 (39%), Gaps = 38/262 (14%)
Query: 278 PPPRASSKRPATADSPKPSAKKQKKSSSKGSRSAPGTSPRTSSSSSFSDKKPAKDKSSTR 337
PPP +SS A +P + + +G + + +S SD DKSS
Sbjct: 95 PPPVSSSDSEAPEANPADGSDADEDDEDRGVMAVTAVTATAASDRMESDSD--SDKSSD- 151
Query: 338 GEKVKAESEPREAKKALEVEESNSEDEASFKSESAQSSP-----SNSSSSSDSSSDSDFE 392
S + AL++ S +AS + A SP S SSS S+ +SD DF
Sbjct: 152 ------NSGLKRKTPALKMSVSKRARKASSDLDQASVSPSEEENSESSSESEKTSDQDFT 205
Query: 393 PSQNHS-----QGPLRSMVEDLQSEESDEDDSSSGEEAAGKTNPGRDSRLSFSDSESDNS 447
P + + +GPL + SD D + + A K P +R + S S S +S
Sbjct: 206 PEKKAAVRAPRRGPLGGRKKKKAPSASDSDSKADSDGA--KPEPVAMARSASSSSSSSSS 263
Query: 448 ADSSLPSREPPPPQKP------------PPPNSKVSGRRSPESCSKPEKILKKGTYDKAY 495
+DS + ++PP +KP P P S S + ++I + D+A
Sbjct: 264 SDSDVSVKKPPRGRKPAEKPLPKPRGRKPKPERPPSSSSSDSDSDEVDRISEWKRRDEAR 323
Query: 496 TDELVELHRR-----LMALRER 512
EL RR L LRE+
Sbjct: 324 RRELEARRRREQEEELRRLREQ 345
Score = 60.5 bits (145), Expect = 4e-09
Identities = 83/377 (22%), Positives = 144/377 (38%), Gaps = 58/377 (15%)
Query: 181 SKDANKESSKTSKPHKVTKEHRERPRKDSESKSSSKELEREQAKSSKDTSRKLGEGRLPK 240
SK A K SS + V+ E SES+ +S + + K++ R+ G L
Sbjct: 167 SKRARKASSDLDQA-SVSPSEEENSESSSESEKTSDQDFTPEKKAAVRAPRR---GPLGG 222
Query: 241 EEKAPPPKAAFKEPK------------MALKETKLESTSPKGGPPPPPPPPPRASSKRPA 288
+K P A+ + K MA + S+S PPR ++PA
Sbjct: 223 RKKKKAPSASDSDSKADSDGAKPEPVAMARSASSSSSSSSSSDSDVSVKKPPRG--RKPA 280
Query: 289 TADSPKPSAKKQKKSSSKGSRSAPGTSPRTSSSSSFSDKK------PAKDKSSTRGEKVK 342
PKP +K K P P +SSS S SD+ +D++ R + +
Sbjct: 281 EKPLPKPRGRKPK----------PERPPSSSSSDSDSDEVDRISEWKRRDEARRRELEAR 330
Query: 343 AESEPREAKKALEVEESNSEDEASFKSESAQSSPSNSSSSSDSSSDSDFEP-----SQNH 397
E E + L +E ++ +++ ++ + SS D + D EP +
Sbjct: 331 RRREQEEELRRLREQEKEEKERRRERADRGEAERGSGGSSGDELREDD-EPVKKRGRKGR 389
Query: 398 SQGPLRSMVEDLQSEESDEDDSSSGEEAAGKTNPGRDSRLSFSDSESDNSADSSLPSREP 457
+GP S + ++E E S+ + + T P R R
Sbjct: 390 GRGPPSSSDSEPEAELEREAKKSAKKPQSSSTEPAR--------------KPGQKEKRVR 435
Query: 458 PPPQKPPPPNSKVSGRRSPESCSKPEKILKKGTYDKAYTDELVELHRRL-MALR-ERNVL 515
P ++ P R+ E S K+ KK + + ++L +LH + AL+ + +
Sbjct: 436 PEEKQQAKPVKVERTRKRSEGFSMDRKVEKK--KEPSVEEKLQKLHSEIKFALKVDSPDV 493
Query: 516 QQIVNLIEETGHFNVTN 532
++ +N +EE G VT+
Sbjct: 494 KRCLNALEELGTLQVTS 510
Score = 41.2 bits (95), Expect = 0.003
Identities = 59/259 (22%), Positives = 108/259 (41%), Gaps = 33/259 (12%)
Query: 165 PLSAFSDPKKTKPSHGSKDANKESSKTSKPHKVTKEHRERPRKDSESKSSSKELEREQAK 224
P S+ ++P + KP K E + +KP KV ER RK SE S +++E+++
Sbjct: 416 PQSSSTEPAR-KPGQKEKRVRPEEKQQAKPVKV-----ERTRKRSEGFSMDRKVEKKKEP 469
Query: 225 SSKDTSRKL-GEGRLPKEEKAPPPKAAFKEPKMALKET-KLESTSPKGGPPPPPPPPPRA 282
S ++ +KL E + + +P K AL+E L+ TS +
Sbjct: 470 SVEEKLQKLHSEIKFALKVDSPDVKRCLN----ALEELGTLQVTSQILQKNTDVVATLKK 525
Query: 283 SSKRPATADSPKPSAKKQKKSSSKGSRSAPGTSPRTSSSSSFSDKKPAKDKSSTRGEKVK 342
+ A D + +A+ + S+ P + + +K+ A++K + GE++
Sbjct: 526 IRRYKANKDVMEKAAEVYTRLKSRVL--GPKIEAVQKVNKAGMEKEKAEEKLA--GEELA 581
Query: 343 AESEPREAKKALEVEESNSEDEASFKSESAQSSPSNSSSSS---DSSSDSDFEPSQNHSQ 399
E P+E +A K + S+P N ++S +S+ D + E ++ +
Sbjct: 582 GEEAPQE--------------KAEDKPSTDLSAPVNGEATSQKGESAEDKEHEEGRDSEE 627
Query: 400 GPLRSMVEDLQSEESDEDD 418
GP EDL + D
Sbjct: 628 GPRCGSSEDLHDSVREGPD 646
>gi|14249158 hepatoma-derived growth factor-related protein 2
isoform 2 [Homo sapiens]
Length = 670
Score = 65.1 bits (157), Expect = 2e-10
Identities = 69/262 (26%), Positives = 104/262 (39%), Gaps = 38/262 (14%)
Query: 278 PPPRASSKRPATADSPKPSAKKQKKSSSKGSRSAPGTSPRTSSSSSFSDKKPAKDKSSTR 337
PPP +SS A +P + + +G + + +S SD DKSS
Sbjct: 95 PPPVSSSDSEAPEANPADGSDADEDDEDRGVMAVTAVTATAASDRMESDSD--SDKSSD- 151
Query: 338 GEKVKAESEPREAKKALEVEESNSEDEASFKSESAQSSP-----SNSSSSSDSSSDSDFE 392
S + AL++ S +AS + A SP S SSS S+ +SD DF
Sbjct: 152 ------NSGLKRKTPALKMSVSKRARKASSDLDQASVSPSEEENSESSSESEKTSDQDFT 205
Query: 393 PSQNHS-----QGPLRSMVEDLQSEESDEDDSSSGEEAAGKTNPGRDSRLSFSDSESDNS 447
P + + +GPL + SD D + + A K P +R + S S S +S
Sbjct: 206 PEKKAAVRAPRRGPLGGRKKKKAPSASDSDSKADSDGA--KPEPVAMARSASSSSSSSSS 263
Query: 448 ADSSLPSREPPPPQKP------------PPPNSKVSGRRSPESCSKPEKILKKGTYDKAY 495
+DS + ++PP +KP P P S S + ++I + D+A
Sbjct: 264 SDSDVSVKKPPRGRKPAEKPLPKPRGRKPKPERPPSSSSSDSDSDEVDRISEWKRRDEAR 323
Query: 496 TDELVELHRR-----LMALRER 512
EL RR L LRE+
Sbjct: 324 RRELEARRRREQEEELRRLREQ 345
Score = 60.5 bits (145), Expect = 4e-09
Identities = 83/377 (22%), Positives = 144/377 (38%), Gaps = 58/377 (15%)
Query: 181 SKDANKESSKTSKPHKVTKEHRERPRKDSESKSSSKELEREQAKSSKDTSRKLGEGRLPK 240
SK A K SS + V+ E SES+ +S + + K++ R+ G L
Sbjct: 167 SKRARKASSDLDQA-SVSPSEEENSESSSESEKTSDQDFTPEKKAAVRAPRR---GPLGG 222
Query: 241 EEKAPPPKAAFKEPK------------MALKETKLESTSPKGGPPPPPPPPPRASSKRPA 288
+K P A+ + K MA + S+S PPR ++PA
Sbjct: 223 RKKKKAPSASDSDSKADSDGAKPEPVAMARSASSSSSSSSSSDSDVSVKKPPRG--RKPA 280
Query: 289 TADSPKPSAKKQKKSSSKGSRSAPGTSPRTSSSSSFSDKK------PAKDKSSTRGEKVK 342
PKP +K K P P +SSS S SD+ +D++ R + +
Sbjct: 281 EKPLPKPRGRKPK----------PERPPSSSSSDSDSDEVDRISEWKRRDEARRRELEAR 330
Query: 343 AESEPREAKKALEVEESNSEDEASFKSESAQSSPSNSSSSSDSSSDSDFEP-----SQNH 397
E E + L +E ++ +++ ++ + SS D + D EP +
Sbjct: 331 RRREQEEELRRLREQEKEEKERRRERADRGEAERGSGGSSGDELREDD-EPVKKRGRKGR 389
Query: 398 SQGPLRSMVEDLQSEESDEDDSSSGEEAAGKTNPGRDSRLSFSDSESDNSADSSLPSREP 457
+GP S + ++E E S+ + + T P R R
Sbjct: 390 GRGPPSSSDSEPEAELEREAKKSAKKPQSSSTEPAR--------------KPGQKEKRVR 435
Query: 458 PPPQKPPPPNSKVSGRRSPESCSKPEKILKKGTYDKAYTDELVELHRRL-MALR-ERNVL 515
P ++ P R+ E S K+ KK + + ++L +LH + AL+ + +
Sbjct: 436 PEEKQQAKPVKVERTRKRSEGFSMDRKVEKK--KEPSVEEKLQKLHSEIKFALKVDSPDV 493
Query: 516 QQIVNLIEETGHFNVTN 532
++ +N +EE G VT+
Sbjct: 494 KRCLNALEELGTLQVTS 510
Score = 42.7 bits (99), Expect = 9e-04
Identities = 62/276 (22%), Positives = 112/276 (40%), Gaps = 33/276 (11%)
Query: 165 PLSAFSDPKKTKPSHGSKDANKESSKTSKPHKVTKEHRERPRKDSESKSSSKELEREQAK 224
P S+ ++P + KP K E + +KP KV ER RK SE S +++E+++
Sbjct: 416 PQSSSTEPAR-KPGQKEKRVRPEEKQQAKPVKV-----ERTRKRSEGFSMDRKVEKKKEP 469
Query: 225 SSKDTSRKL-GEGRLPKEEKAPPPKAAFKEPKMALKET-KLESTSPKGGPPPPPPPPPRA 282
S ++ +KL E + + +P K AL+E L+ TS +
Sbjct: 470 SVEEKLQKLHSEIKFALKVDSPDVKRCLN----ALEELGTLQVTSQILQKNTDVVATLKK 525
Query: 283 SSKRPATADSPKPSAKKQKKSSSKGSRSAPGTSPRTSSSSSFSDKKPAKDKSSTRGEKVK 342
+ A D + +A+ + S+ P + + +K+ A++K + GE++
Sbjct: 526 IRRYKANKDVMEKAAEVYTRLKSRVL--GPKIEAVQKVNKAGMEKEKAEEKLA--GEELA 581
Query: 343 AESEPREAKKALEVEESNSEDEASFKSESAQSSPSNSSSSS---DSSSDSDFEPSQNHSQ 399
E P+E +A K + S+P N ++S +S+ D + E ++ +
Sbjct: 582 GEEAPQE--------------KAEDKPSTDLSAPVNGEATSQKGESAEDKEHEEGRDSEE 627
Query: 400 GPLRSMVEDLQSEESDEDDSSSGEEAAGKTNPGRDS 435
GP EDL D G + + DS
Sbjct: 628 GPRCGSSEDLHDVREGPDLDRPGSDRQERERARGDS 663
>gi|117938251 BCL2-associated transcription factor 1 isoform 2 [Homo
sapiens]
Length = 869
Score = 64.7 bits (156), Expect = 2e-10
Identities = 89/353 (25%), Positives = 136/353 (38%), Gaps = 51/353 (14%)
Query: 178 SHGSKDANKESSKT---SKPHKVTKEHRERPRKDSESKSSSKELEREQAKSSKDTSRKL- 233
SH S+ ++ S + S+ H K +R R R S S+S + R+ + ++
Sbjct: 8 SHSSRSKSRSQSSSRSRSRSHSRKKRYRSRSRTYSRSRSRDRMYSRDYRRDYRNNRGMRR 67
Query: 234 -----GEGRLPKEEKAPPPKAAFKEPKMALKETKLESTSPKGGPPPPPPPPPRASSKRPA 288
G GR + P + S SP+ G R+ S+ P
Sbjct: 68 PYGYRGRGRGYYQGGGGRYHRGGYRPVW----NRRHSRSPRRG---------RSRSRSPK 114
Query: 289 TADSPKPSAKKQKKSSSKGSRSAPGTSPRTSSSSSFSDKKPAKDKSSTRGEKVKAESEPR 348
++ + + S + SRS +S R SSS +S +K + S + KAE EP+
Sbjct: 115 RRSVSSQRSRSRSRRSYRSSRSPRSSSSR--SSSPYSKSPVSKRRGSQEKQTKKAEGEPQ 172
Query: 349 -----------EAKKALEVEESNSEDEASFKSESA------QSSPSNSSSSSDSSSDSDF 391
E K E + S S DE + S ++ S+ NS S S S
Sbjct: 173 EESPLKSKSQEEPKDTFEHDPSESIDEFNKSSATSGDIWPGLSAYDNSPRSPHSPSPIAT 232
Query: 392 EPSQNH--SQGPLRSMVEDLQSEESDEDDSSSGEEAAGKTNPGRDSRLSFSDSESDNSAD 449
PSQ+ S P+ S V ++ S S S + + ++ G S S S NS
Sbjct: 233 PPSQSSSCSDAPMLSTVHSAKNTPSQH--SHSIQHSPERSGSGSVGNGSSRYSPSQNSPI 290
Query: 450 SSLPSREPP----PPQKPPPPNSKVSGRRSPESCSKPEKILKKGTYDKAYTDE 498
+PSR P PQ P S+ GR S ++ K G + K +TDE
Sbjct: 291 HHIPSRRSPAKTIAPQNAPRDESR--GRSSFYPDGGDQETAKTGKFLKRFTDE 341
Score = 47.8 bits (112), Expect = 3e-05
Identities = 58/264 (21%), Positives = 92/264 (34%), Gaps = 35/264 (13%)
Query: 199 KEHRERPRKDSESKSSSKELEREQAKSSKDTSRKLGEGRLPKEEKAPPPKAAFKEPKMAL 258
+ H PR+ S K +S + R R P+ + K P
Sbjct: 97 RRHSRSPRRGRSRSRSPKRRSVSSQRSRSRSRRSYRSSRSPRSSSSRSSSPYSKSPVSKR 156
Query: 259 KETKLESTSPKGGPPPPPPPPPRASSKRPATA--DSPKPSAKKQKKSSSKGSRSAPG--- 313
+ ++ + T G P P S + P P S + KSS+ PG
Sbjct: 157 RGSQEKQTKKAEGEPQEESPLKSKSQEEPKDTFEHDPSESIDEFNKSSATSGDIWPGLSA 216
Query: 314 --TSPRTSSSSSFSDKKPAKDKSSTRGEKVKAESEPREAKKALEVEESNSEDEASFKSES 371
SPR+ S S P++ S + + ++++ S S S
Sbjct: 217 YDNSPRSPHSPSPIATPPSQSSSCSDAPMLST--------------VHSAKNTPSQHSHS 262
Query: 372 AQSSPSNSSSSSDSSSDSDFEPSQN---HSQGPLRSMVEDLQSEESDEDDS--------S 420
Q SP S S S + S + PSQN H RS + + + + D+S
Sbjct: 263 IQHSPERSGSGSVGNGSSRYSPSQNSPIHHIPSRRSPAKTIAPQNAPRDESRGRSSFYPD 322
Query: 421 SGEEAAGKTNPGRDSRLSFSDSES 444
G++ KT G+ + F+D ES
Sbjct: 323 GGDQETAKT--GKFLK-RFTDEES 343
Score = 38.1 bits (87), Expect = 0.021
Identities = 59/311 (18%), Positives = 106/311 (34%), Gaps = 42/311 (13%)
Query: 172 PKKTKPSHGSKDANKESSKTSKPHKVTKEHRERPRKDSESKSSS----KELEREQAKSSK 227
P++ + S SS+ S+ R + S S+SSS + + + K
Sbjct: 103 PRRGRSRSRSPKRRSVSSQRSRSRSRRSYRSSRSPRSSSSRSSSPYSKSPVSKRRGSQEK 162
Query: 228 DTSRKLGEGRLPKEEKAPPPKAAFKEPKMALKETKLES---------------------- 265
T + GE +E++P + +EPK + ES
Sbjct: 163 QTKKAEGE----PQEESPLKSKSQEEPKDTFEHDPSESIDEFNKSSATSGDIWPGLSAYD 218
Query: 266 TSPKG--GPPPPPPPPPRASSKRPATADSPKPSAKKQKKSSSKGSRSAPGTSPRTSSSSS 323
SP+ P P PP ++SS A S SAK S + +P S S +
Sbjct: 219 NSPRSPHSPSPIATPPSQSSSCSDAPMLSTVHSAKNTPSQHSHSIQHSPERSGSGSVGNG 278
Query: 324 FSDKKPAKDKSSTRGEKVKAESEPREAKKALEVEESNSEDEASFKSESAQSSPSNSSSSS 383
S P+++ + + P + S +SF + + +
Sbjct: 279 SSRYSPSQNSPI---HHIPSRRSPAKTIAPQNAPRDESRGRSSFYPDGGDQETAKTGKFL 335
Query: 384 DSSSDSDFEPSQNHSQGPLRSMVEDLQSEESDEDDSSSGE----EAAGKTNPGRDSRLSF 439
+D E S+ + ++ E+ E + GE EA + + F
Sbjct: 336 KRFTD---EESRVFLLDRGNTRDKEASKEKGSEKGRAEGEWEDQEALDYFSDKESGKQKF 392
Query: 440 SDSESDNSADS 450
+DSE D++ ++
Sbjct: 393 NDSEGDDTEET 403
Score = 32.3 bits (72), Expect = 1.2
Identities = 56/268 (20%), Positives = 94/268 (35%), Gaps = 15/268 (5%)
Query: 152 SRPSPDYPMLPTIPLSAFSDPKKTKPSHGS-KDANKESSKTSKPHKVTKEHRERPRKDSE 210
SR S Y P + S K+TK + G ++ + SK+ + K T EH D
Sbjct: 142 SRSSSPYSKSP-VSKRRGSQEKQTKKAEGEPQEESPLKSKSQEEPKDTFEHDPSESIDEF 200
Query: 211 SKSSSKELEREQAKSSKDTSRKLGEGRLPKEEKAPPPKAAFKEPKMALKETKLESTSPKG 270
+KSS+ + S+ D S + P PP +++ L +P
Sbjct: 201 NKSSATSGDIWPGLSAYDNSPR--SPHSPSPIATPPSQSSSCSDAPMLSTVHSAKNTPSQ 258
Query: 271 GPPPPPPPPPRASSKRPATADSPKPSAKKQKKSSSKGSRS-----APGTSPRTSSSSSFS 325
P R+ S S ++ RS AP +PR S S
Sbjct: 259 HSHSIQHSPERSGSGSVGNGSSRYSPSQNSPIHHIPSRRSPAKTIAPQNAPRDESRGRSS 318
Query: 326 DKKPAKDKSSTRGEKVKAESEPREAKKALEVEESNSEDEASFKSESAQSSPSNSSSSSDS 385
D+ + + K E++ L ++ N+ D+ + K + ++ +
Sbjct: 319 FYPDGGDQETAKTGKFLKRFTDEESRVFL-LDRGNTRDKEASKEKGSEKGRAEGEWEDQE 377
Query: 386 SSD--SDFEPSQ---NHSQGPLRSMVED 408
+ D SD E + N S+G ED
Sbjct: 378 ALDYFSDKESGKQKFNDSEGDDTEETED 405
Score = 30.0 bits (66), Expect = 5.8
Identities = 17/72 (23%), Positives = 33/72 (45%), Gaps = 1/72 (1%)
Query: 173 KKTKPSHGSKDANKESSKTSKPHKVTKEHRE-RPRKDSESKSSSKELEREQAKSSKDTSR 231
K+ G ++ESS + K K K+++E + KD ++ R + S+ +S
Sbjct: 700 KERSKERGDSKGSRESSGSRKQEKTPKDYKEYKSYKDDSKHKREQDHSRSSSSSASPSSP 759
Query: 232 KLGEGRLPKEEK 243
E + K+E+
Sbjct: 760 SSREEKESKKER 771
>gi|16332370 cell division cycle 2-like 1 (PITSLRE proteins) isoform
8 [Homo sapiens]
Length = 780
Score = 63.9 bits (154), Expect = 4e-10
Identities = 87/375 (23%), Positives = 142/375 (37%), Gaps = 62/375 (16%)
Query: 179 HGSKDANKESSKTSKPHKVTKEHRERPRKDSESKSSSKELER------------------ 220
H KD ++ K ++ + +EH R R E + +E ER
Sbjct: 98 HHRKDEKRKEKKHARVKEKEREHERRKRHREEQDKARREWERQKRREMAREHSRRERGND 157
Query: 221 ---------EQAKSSKDTSRKLGEGRLPKEEKAPPPKAAFKEPK--------MALKETKL 263
EQ + ++ RK+ E + + E+ + A + K A T
Sbjct: 158 GVCLFRDRLEQLERKRERERKMREQQKEQREQKERERRAEERRKEREARREVSAHHRTMR 217
Query: 264 ESTSPKGGPPPPPPPPPRASSKRPATADSPKPSAKKQKKSSSKGSRSAPGTSPRTSSSSS 323
E S K PPR +R D KP K++K + S S
Sbjct: 218 EDYSDKVKASHWSRSPPRPPRERFELGDGRKPV--KEEKMEERDLLS-------DLQDIS 268
Query: 324 FSDKKPAKDKSST----RGEKVKAESEPREAKKALEVEESNSEDEASFKSESAQSSPSNS 379
S++K + +SS+ G + + E E E ++ EES E+E + E S S
Sbjct: 269 DSERKTSSAESSSAESGSGSEEEEEEEEEEEEEGSTSEESEEEEEEEEEEEEETGSNSEE 328
Query: 380 SSSSDSSSDSDFEPSQNHSQGPLRSMVEDLQSE-ESDEDDSSSGEEAAGKTNPGRDSRLS 438
+S + S+ E S++ + ++ +S + D +S EE G+ P + S L+
Sbjct: 329 ASEQSAEEVSEEEMSEDEERENENHLLVVPESRFDRDSGESEEAEEEVGEGTP-QSSALT 387
Query: 439 FSDSESDNSADSSLPSREPPPPQKPPPPNSKVSGRRSPESCSKPEKILKKGTYDKAY--- 495
D D+ A S + ++ P P + G RS E +I ++GTY Y
Sbjct: 388 EGDYVPDSPALSPIELKQELPKYLP-----ALQGCRSVEEFQCLNRI-EEGTYGVVYRAK 441
Query: 496 ---TDELVELHRRLM 507
TDE+V L R M
Sbjct: 442 DKKTDEIVALKRLKM 456
>gi|224548936 hypothetical protein LOC100170229 [Homo sapiens]
Length = 715
Score = 62.8 bits (151), Expect = 8e-10
Identities = 77/335 (22%), Positives = 126/335 (37%), Gaps = 31/335 (9%)
Query: 167 SAFSDPKKTKPSHGSKDANK--ESSKTSKPHKVTKEHRERP----RKDSESKSSSKELER 220
S P K + S+ NK + S++ P+K R R R S S+S K +R
Sbjct: 390 SQSGSPNKQRDHSRSRSPNKARDRSRSRSPYKARDRSRSRSPNKARDCSRSRSPYKARDR 449
Query: 221 EQAKS---SKDTSRKLGEGRLPKEEKAPPPKAAFKEPKMALKETKLESTSPKGGPPPPPP 277
+++S ++D SR + ++ P ++ + + +
Sbjct: 450 SRSRSPNKARDHSRSRSPNKARDRSRSRSPSKERDHSQLGSPSKERDHRRSRSPSKERQC 509
Query: 278 PPPRASSKRPATADSPKPSAKKQKKSSSKGSRSAPGTSPRTSSS--SSFSDKKPAKDKSS 335
R+SSK S PS ++Q++ S ++ + R+ S + P+K++
Sbjct: 510 RQSRSSSKERDHRRSRSPSKERQRRQSRSPNKERDRSQSRSPSEEREHRQSRSPSKERDR 569
Query: 336 TRGEKVKAESEPREAKKALEVEESNSEDEASFKSESAQSSPSNSSSSSDSSSDSDFEPSQ 395
R E E R+++ + EE + S +S S P SS S
Sbjct: 570 RRWRSPSKERERRQSRSS--SEERDHSRSRSPNKQSGYSRPRASSKEKAHSRSRTPSKEG 627
Query: 396 NHSQGPLRSMVEDLQSEESDEDDSSSGEEAAGKTNPGRDSRLSFSDSESDNSADSSLPSR 455
NHSQ S+ESD S+ K +P R S LS + + S S+ S PS
Sbjct: 628 NHSQ-------SRTSSKESDPSQSTVPRSPDWKRSPTRTSSLSQNRTPSKTSSHS--PST 678
Query: 456 EPPPPQKPPPPNSK---------VSGRRSPESCSK 481
P Q +S+ + G RS S SK
Sbjct: 679 FPSGGQTLSQDDSQADATTSKATLPGERSSSSSSK 713
Score = 49.7 bits (117), Expect = 7e-06
Identities = 75/342 (21%), Positives = 126/342 (36%), Gaps = 47/342 (13%)
Query: 181 SKDANKESSKTSKPHKVTKEHR--ERPRKDSESKSSSKELEREQAKSSKDTSRKLGEGRL 238
SK ++ S+T + + R + R S S+SSSKE + + S + S + G
Sbjct: 336 SKGKSQNQSRTPRRGRSHNWSRNPSKERSHSHSRSSSKERDHRGSSSPRKESGRSQSGSP 395
Query: 239 PKE----EKAPPPKAAFKEPKMALKETKLESTSPKGGPPPPPPPPPRASSKRPATADSPK 294
K+ P KA + + + + S S P + S+ P A
Sbjct: 396 NKQRDHSRSRSPNKARDRSRSRSPYKARDRSRSRS-----PNKARDCSRSRSPYKARDRS 450
Query: 295 PSAKKQKKSSSKGSRSAPGTSPRTSSSSSFSDK------KPAKDKSSTRGEKVKAESEPR 348
S K SRS R+ S S ++ P+K++ R E + R
Sbjct: 451 RSRSPNKARDHSRSRSPNKARDRSRSRSPSKERDHSQLGSPSKERDHRRSRSPSKERQCR 510
Query: 349 EAKKALEVEESNSEDEASFKSESAQS-SPSNSSSSSDSSSDSD-------FEPSQNHSQG 400
+++ + + + S + + QS SP+ S S S S+ PS+ +
Sbjct: 511 QSRSSSKERDHRRSRSPSKERQRRQSRSPNKERDRSQSRSPSEEREHRQSRSPSKERDRR 570
Query: 401 PLRSMVEDLQ-------SEESDEDDSSSGEEAAGKTNPGRDSR-----LSFSDSESDNSA 448
RS ++ + SEE D S S + +G + P S+ S + S+ N +
Sbjct: 571 RWRSPSKERERRQSRSSSEERDHSRSRSPNKQSGYSRPRASSKEKAHSRSRTPSKEGNHS 630
Query: 449 DSSLPSREPPPPQ----------KPPPPNSKVSGRRSPESCS 480
S S+E P Q + P S +S R+P S
Sbjct: 631 QSRTSSKESDPSQSTVPRSPDWKRSPTRTSSLSQNRTPSKTS 672
Score = 48.5 bits (114), Expect = 2e-05
Identities = 54/241 (22%), Positives = 94/241 (39%), Gaps = 29/241 (12%)
Query: 254 PKMALKETKLESTSPKGGPPPPPPPPPRASSKRPATAD----SPKPSAKKQKKSSSKGSR 309
PK + K + + S P P PP S + AT + KP+ + S S+
Sbjct: 4 PKRSSKPSMSLAPSGSSMPTADPKPPASLKSTKSATPNRSLVPTKPATSRNSVMSPSSSK 63
Query: 310 SAPGTSPRTSSSSSFSDKKPAKDKSSTRGEKVKAESEPREAKKALEVE-------ESNSE 362
S TS + + S+ S + + K+ T +V ++ +A KA +V S
Sbjct: 64 STKSTSTKRAPSNRPSSRSRVRSKART-PSRVSTDTRTSKASKASDVRCHQRRGTHSRGR 122
Query: 363 DEASFKSESAQSSPSNSS--------------SSSDSSSDSDFEPSQNHSQGPLRSMVED 408
S S++ SPS +S +S + S + S+ S G R+ +
Sbjct: 123 TPGRRGSRSSKRSPSRASTPGRIRTHGARPGMASRVRTPTSQQKGSRGKSYGRPRTSNRE 182
Query: 409 LQSEESDEDDSSSGEEAAGKTNPGRDSRLSFSDSESDNSADSSLPSREPPPPQKPPPPNS 468
+S+ + S G + GR S L+ + S + + +PS+E P P +S
Sbjct: 183 -RSDSQPRNLSKKSYRPPGGSGIGRSSELAVTPSTAKCQTPTGIPSKE--KSDNPSPSSS 239
Query: 469 K 469
+
Sbjct: 240 R 240
Score = 45.1 bits (105), Expect = 2e-04
Identities = 66/299 (22%), Positives = 107/299 (35%), Gaps = 10/299 (3%)
Query: 186 KESSKTSKPHKVTKEHRERPRKDSESKSSSKELEREQAKSSKDTSRKLGEGRLPKEEKAP 245
K S T +V ++ R +S S S+ R ++ S K T ++ +
Sbjct: 255 KSYSPTEMSSRVKSYNQASTRSRPQSHSQSRSPRRSRSGSQKRTHSRVRSHSWKRNHSRA 314
Query: 246 PPKAAFKEPKMALKETKLESTSPKGGPPPPPPPPPRASSKRPATADSPKPSAKKQKKSSS 305
++ ++ ++ +S S G PR + + K + +SSS
Sbjct: 315 --RSRTRKGILSQMGRHSQSRSHSKGKSQNQSRTPRRGRSHNWSRNPSKERSHSHSRSSS 372
Query: 306 KGSRSAPGTSPRTSS--SSSFSDKKPAKDKSSTRGEKVKAESEPREAKKALEVEESNSED 363
K +SPR S S S S K S K + S R KA + S S +
Sbjct: 373 KERDHRGSSSPRKESGRSQSGSPNKQRDHSRSRSPNKARDRSRSRSPYKARDRSRSRSPN 432
Query: 364 EASFKSESA---QSSPSNSSSSSDSSSDSDFEPSQNHSQGPLRSMVEDLQSEESDEDDSS 420
+A S S ++ + S S + + D S N ++ RS + + S S
Sbjct: 433 KARDCSRSRSPYKARDRSRSRSPNKARDHSRSRSPNKARDRSRSRSPSKERDHSQLGSPS 492
Query: 421 SGEEAAGKTNPG--RDSRLSFSDSESDNSADSSLPSREPPPPQKPPPPNSK-VSGRRSP 476
+ +P R R S S S+ + S PS+E Q P + S RSP
Sbjct: 493 KERDHRRSRSPSKERQCRQSRSSSKERDHRRSRSPSKERQRRQSRSPNKERDRSQSRSP 551
Score = 38.5 bits (88), Expect = 0.016
Identities = 61/298 (20%), Positives = 107/298 (35%), Gaps = 27/298 (9%)
Query: 156 PDYPMLPTIPLSAFSDPKKTKPSHGSKDANKESSKTSKPHKVTKEHRERPRKDSESKSSS 215
P + P+ +DPK A+ +S+K++ P++ + ++S SS
Sbjct: 10 PSMSLAPSGSSMPTADPKPP--------ASLKSTKSATPNRSLVPTKPATSRNSVMSPSS 61
Query: 216 KELEREQAKSSKDTSRKLGEGRLPKEEKAPPPKAAFKEPKMALKETKLESTSPKGGPPPP 275
+ + + ++R R+ + + P + A K + + +G
Sbjct: 62 SKSTKSTSTKRAPSNRPSSRSRVRSKARTPSRVSTDTRTSKASKASDVRCHQRRGTHSRG 121
Query: 276 PPPPPRAS--SKR-PATADSP-----------KPSAKKQKKSSSKGSRSAPGTSPRTSSS 321
P R S SKR P+ A +P S + S KGSR PRTS+
Sbjct: 122 RTPGRRGSRSSKRSPSRASTPGRIRTHGARPGMASRVRTPTSQQKGSRGKSYGRPRTSNR 181
Query: 322 SSFSDKKPAKDKSSTRGEKVKAESEPREAKKALEVEESNSEDEASFKSESAQSSPSNSSS 381
SD +P ++ S R ++ A+ + + S+ +PS SSS
Sbjct: 182 ER-SDSQP-RNLSKKSYRPPGGSGIGRSSELAVTPSTAKCQTPTGIPSKEKSDNPSPSSS 239
Query: 382 SSDSSSDSDFEPSQNHSQGP--LRSMVEDL-QSEESDEDDSSSGEEAAGKTNPGRDSR 436
S PS+ S P + S V+ Q+ S S + ++ G R
Sbjct: 240 RKVKSYGQMIIPSREKSYSPTEMSSRVKSYNQASTRSRPQSHSQSRSPRRSRSGSQKR 297
>gi|226509740 SR-related CTD-associated factor 1 [Homo sapiens]
Length = 1312
Score = 62.4 bits (150), Expect = 1e-09
Identities = 87/364 (23%), Positives = 137/364 (37%), Gaps = 60/364 (16%)
Query: 170 SDPKKTKPSHGSKDANKESSKTSKPHKVTKEHRER---PRKDSESKSSSKELEREQ---- 222
S + T+ S D + S+ S+ + + R P S S SS +E R +
Sbjct: 578 SRSRSTRRRSRSTDRRRGGSRRSRSREKRRRRRRSASPPPATSSSSSSRRERHRGKHRDG 637
Query: 223 --AKSSKDTSRKLGEGRLPKEEK-----APPPKAAFK---------------------EP 254
+K K SR GE R + APPP +
Sbjct: 638 GGSKKKKKRSRSRGEKRSGDGSEKAPAPAPPPSGSTSCGDRDSRRRGAVPPSIQDLTDHD 697
Query: 255 KMALKET----KLESTSPKGGPPPPPPPPPRASSKRPATADSPKPSAKKQKKSSSKGSRS 310
A+K T +L+ + P+G P P P +S KR DS S +++ SS+ R
Sbjct: 698 LFAIKRTITVGRLDKSDPRG-----PSPAPASSPKREVLYDSEGLSGEERGGKSSQKDRR 752
Query: 311 APGTSPRTSSSSSFSDKKPAKDKSSTRGEKVKAESEPREAKKALEVEESNSEDEASFKSE 370
G + +SSS ++ A D ++ + R +KKA +E S S
Sbjct: 753 RSGAASSSSSSREKGSRRKALDGGDRDRDRDRDRDRDRSSKKARPPKE-------SAPSS 805
Query: 371 SAQSSPSNSSSSSDSSSDSDFEPSQNHSQGPLRSMV-EDLQSEESDEDDSSSGEEAAG-K 428
P SS S SSS S + Q + ++ E + S +D +S+G + G K
Sbjct: 806 GPPPKPPVSSGSGSSSSSSSCSSRKVKLQSKVAVLIREGVSSTTPAKDAASAGLGSIGVK 865
Query: 429 TNPGRDSRLSFSDSESDNSADSSLPSREPPPPQKPPPPNSKVSG----RRSPESCSKPEK 484
+ R+SR F + D A + + ++ P KP K + + +KP K
Sbjct: 866 FSRDRESRSPF--LKPDERAPTEM-AKAAPGSTKPKKTKVKAKAGAKKTKGTKGKTKPSK 922
Query: 485 ILKK 488
KK
Sbjct: 923 TRKK 926
Score = 55.8 bits (133), Expect = 1e-07
Identities = 72/328 (21%), Positives = 117/328 (35%), Gaps = 51/328 (15%)
Query: 170 SDPKKTKPSHGSKDANK---ESSKTSKPHKVTKEHRERPRKDSESKSSSKELEREQAKSS 226
SDP+ P+ S + +S S + K ++ R+ + SSS E+ + +
Sbjct: 713 SDPRGPSPAPASSPKREVLYDSEGLSGEERGGKSSQKDRRRSGAASSSSSSREKGSRRKA 772
Query: 227 -----KDTSRKLGEGRLPKEEKAPPPKAAFKEPKMALKETKLESTSPKGGPPPPPPPPPR 281
+D R R +KA PPK ++P GPPP PP
Sbjct: 773 LDGGDRDRDRDRDRDRDRSSKKARPPK----------------ESAPSSGPPPKPP---- 812
Query: 282 ASSKRPATADSPKPSAKKQKKSSSKGSRSAPGTSPRTSSSSSFS------DKKPAKDKSS 335
SS +++ S S++K K S G S T + + S K ++D+ S
Sbjct: 813 VSSGSGSSSSSSSCSSRKVKLQSKVAVLIREGVSSTTPAKDAASAGLGSIGVKFSRDRES 872
Query: 336 TRGEKVKAESEPREAKKALEVEESNSEDEASFKSESAQSSPSNSSSSSDSSSDSDFEPSQ 395
E P E KA S + K+++ + + S S
Sbjct: 873 RSPFLKPDERAPTEMAKA--APGSTKPKKTKVKAKAGAKKTKGTKGKTKPSKTRKKVRSG 930
Query: 396 NHSQGPLRSMVEDLQSEESDEDDSSSGEEAAGKTNPGRDSRLSFSDSESDNSADSSLPSR 455
S G + L+ ++D ++G + A +T+ + R + +PS
Sbjct: 931 GGSGGSGGQV--SLKKSKADSCSQAAGTKGAEETSWSGEERAA------------KVPST 976
Query: 456 EPPPPQKPPPPNSKVSGRRSPESCSKPE 483
PPP PPPP + SC PE
Sbjct: 977 -PPPKAAPPPPALTPDSQTVDSSCKTPE 1003
Score = 48.1 bits (113), Expect = 2e-05
Identities = 95/445 (21%), Positives = 144/445 (32%), Gaps = 116/445 (26%)
Query: 135 LLRAGGVMVMPEGADTVSR-----PSPDYPMLPT----IPLSAFSDPKKT------KPSH 179
L R GG P A + + P P P P + L A SD + +P+
Sbjct: 409 LFRPGGRAARPTPAASATPTAQPLPQPPAPRAPEGDDFLSLHAESDGEGALQVDLGEPAP 468
Query: 180 GSKDANKESSKTSKPHKVTKEHRERPRKDSESKSSSKELEREQAKSSKDTSRKLGEGRLP 239
A+ K+ + RER R+ S S + + P
Sbjct: 469 APPAADSRWGGLDLRRKILTQRRERYRQRSPSPAPAPA---------------------P 507
Query: 240 KEEKAPPPKAAFKEPKMALKETKLESTSPKGGPPPPPPPPPRASSKRPATADSPKP---- 295
PP + + + E K ++S G P PP P SK+ + D KP
Sbjct: 508 AAAAGPPTRKKSRRERKRSGEAKEAASSSSGTQPAPPAPASPWDSKKHRSRDR-KPGSHA 566
Query: 296 --SAKKQKKSSSK----------------GSRSAPGTSPRTSSSSSFSDKKPAKDKSSTR 337
SA+++ +S S+ GSR + R S S SS+R
Sbjct: 567 SSSARRRSRSRSRSRSTRRRSRSTDRRRGGSRRSRSREKRRRRRRSASPPPATSSSSSSR 626
Query: 338 GEKVKAESE----PREAKKALEVEESNSEDEASFKSESAQSSPSNSSSSSDSSS------ 387
E+ + + ++ KK + S K+ + PS S+S D S
Sbjct: 627 RERHRGKHRDGGGSKKKKKRSRSRGEKRSGDGSEKAPAPAPPPSGSTSCGDRDSRRRGAV 686
Query: 388 --------DSDF------------------EPSQNHSQGPLRSMV---EDLQSEE----- 413
D D PS + P R ++ E L EE
Sbjct: 687 PPSIQDLTDHDLFAIKRTITVGRLDKSDPRGPSPAPASSPKREVLYDSEGLSGEERGGKS 746
Query: 414 SDEDDSSSGEEAAGKTNPGRDSRLSF-----------SDSESDNSADSSLPSREPPPPQK 462
S +D SG ++ ++ + SR D + D S+ + P +E P
Sbjct: 747 SQKDRRRSGAASSSSSSREKGSRRKALDGGDRDRDRDRDRDRDRSSKKARPPKESAPSSG 806
Query: 463 PP--PPNSKVSGRRSPESCSKPEKI 485
PP PP S SG S S K+
Sbjct: 807 PPPKPPVSSGSGSSSSSSSCSSRKV 831
Score = 45.1 bits (105), Expect = 2e-04
Identities = 47/180 (26%), Positives = 68/180 (37%), Gaps = 16/180 (8%)
Query: 222 QAKSSKDT-SRKLGEGRLPKEEKAPP-PKAAFKEPKMALKETKLESTSPKGGPPPPPPPP 279
Q+ SS+ T +R L G PP P +A P + S+SP PPPPPP P
Sbjct: 163 QSNSSRPTCARHLTLGTGDGGPAPPPAPSSASSSPSPSPS-----SSSPSPPPPPPPPAP 217
Query: 280 PRASSKRPATADSPKPSAKKQKKSSSKGSRSAPGTSPRTSSSSSFSDKKPAKDKSSTRGE 339
P + R D P+ + + + P ++ SSS P E
Sbjct: 218 PAPPAPRFDIYDPFHPTDEAYSPPPAPEQKYDPFEPTGSNPSSSAGTPSP---------E 268
Query: 340 KVKAESEPREAKKALEVEESNSEDEASFKSESAQSSPSNSSSSSDSSSDSDFEPSQNHSQ 399
+ + E E E ++ E EE S SE+ ++S S D D P +Q
Sbjct: 269 EEEEEEEEEEEEEEDEEEEEGLSQSISRISETLAGIYDDNSLSQDFPGDESPRPDAQPTQ 328
Score = 37.0 bits (84), Expect = 0.048
Identities = 57/241 (23%), Positives = 82/241 (34%), Gaps = 66/241 (27%)
Query: 172 PKKTK--PSHGSKDANKESSKTSKPHKVTKEHRERPRKDSE----SKSSSKELEREQA-- 223
PKKTK G+K KT KP K K+ R S SK QA
Sbjct: 897 PKKTKVKAKAGAKKTKGTKGKT-KPSKTRKKVRSGGGSGGSGGQVSLKKSKADSCSQAAG 955
Query: 224 -KSSKDTSRKLGEGRLPKEEKAPPPKAAFKEPKMALKETKLESTSPKGGPPPPPPPPPRA 282
K +++TS GE R K PPPKA PPPP
Sbjct: 956 TKGAEETSWS-GEERAAKVPSTPPPKA-----------------------APPPPALTPD 991
Query: 283 SSKRPATADSPKPSAKKQKKSSSKGSRSAPGTSPRTSSSSSFSDKKPAKDKSSTRGEKVK 342
S ++ +P+ S ++ + G R
Sbjct: 992 SQTVDSSCKTPEVSFLPEEATEEAGVRGG------------------------------A 1021
Query: 343 AESEPREAKKALEVEESNSEDEASFKSESAQSSPSNSSSSSDSSSDSDFE--PSQNHSQG 400
E E E ++ E EE + + + +A ++PS + S+ ++ DS E P+ SQ
Sbjct: 1022 EEEEEEEEEEEEEEEEEEQQPATTTATSTAAAAPSTAPSAGSTAGDSGAEDGPASRVSQL 1081
Query: 401 P 401
P
Sbjct: 1082 P 1082
Score = 36.6 bits (83), Expect = 0.062
Identities = 59/301 (19%), Positives = 101/301 (33%), Gaps = 47/301 (15%)
Query: 232 KLGEGRLPKEEKAPP-PKAAFKEPKMALKETKLESTSPKGGPPPPPPPP--PRASSKRPA 288
++ EG + + E+ P + F+ A + T S +P P P PP P P
Sbjct: 390 EIEEGEIVQPEEEPRLALSLFRPGGRAARPTPAASATPTAQPLPQPPAPRAPEGDDFLSL 449
Query: 289 TADS--------------PKPSAK--------------KQKKSSSKGSRSAPGTSPRTSS 320
A+S P P A Q++ + +P +P ++
Sbjct: 450 HAESDGEGALQVDLGEPAPAPPAADSRWGGLDLRRKILTQRRERYRQRSPSPAPAPAPAA 509
Query: 321 SSSFSDKKPAKDKSSTRGEKVKAESEPREAKKALEVEESNSEDEASFKSESAQSSPSNSS 380
++ +K ++ + GE +A S + A S + + + S ++SS
Sbjct: 510 AAGPPTRKKSRRERKRSGEAKEAASSSSGTQPAPPAPASPWDSKKHRSRDRKPGSHASSS 569
Query: 381 SSSDSSSDSDFEPSQNHSQ-------GPLRSMVEDLQSEE---------SDEDDSSSGEE 424
+ S S S ++ S+ G RS + + + SS E
Sbjct: 570 ARRRSRSRSRSRSTRRRSRSTDRRRGGSRRSRSREKRRRRRRSASPPPATSSSSSSRRER 629
Query: 425 AAGKTNPGRDSRLSFSDSESDNSADSSLPSREPPPPQKPPPPNSKVSGRRSPESCSKPEK 484
GK G S+ S S S S + P P PP ++ R S + P
Sbjct: 630 HRGKHRDGGGSKKKKKRSRSRGEKRSGDGSEKAPAPAPPPSGSTSCGDRDSRRRGAVPPS 689
Query: 485 I 485
I
Sbjct: 690 I 690
Score = 34.3 bits (77), Expect = 0.31
Identities = 44/203 (21%), Positives = 64/203 (31%), Gaps = 50/203 (24%)
Query: 270 GGPPPPPPPPPRASSKRPATADSPKPSAKKQKKSSSKGSRSAPGTSPRTSSSSSFSDKKP 329
GGP PPP P +SS P S S S S P P + + + +
Sbjct: 182 GGPAPPPAPSSASSSPSP---------------SPSSSSPSPPPPPPPPAPPAPPAPRFD 226
Query: 330 AKDKSSTRGEKVKAESEPREAKKALEVEESNSEDEASFKSESAQSSPSNSSSSSDSSSDS 389
D E P + K + + + SN SSS+ + S
Sbjct: 227 IYDPFHPTDEAYSPPPAPEQ------------------KYDPFEPTGSNPSSSAGTPSPE 268
Query: 390 DFEPSQNHSQGPLRSMVEDLQSEESDEDDSSSGEEAAGKTNPGRDSRLSFSDSESDNSAD 449
+ E E+ + EE +E+D EE G + + + DNS
Sbjct: 269 EEE--------------EEEEEEEEEEEDE---EEEEGLSQSISRISETLAGIYDDNSLS 311
Query: 450 SSLPSREPPPPQKPPPPNSKVSG 472
P E P P P + G
Sbjct: 312 QDFPGDESPRPDAQPTQPTPAPG 334
Score = 30.0 bits (66), Expect = 5.8
Identities = 18/45 (40%), Positives = 20/45 (44%), Gaps = 1/45 (2%)
Query: 422 GEEAAGKTNPGRDSRLSFSDSESDNSADSSLPSREPPPPQKPPPP 466
G G P S S S S S +S+ S P PPPP P PP
Sbjct: 178 GTGDGGPAPPPAPSSASSSPSPSPSSSSPS-PPPPPPPPAPPAPP 221
Database: hs.faa
Posted date: Aug 4, 2009 4:42 PM
Number of letters in database: 18,247,518
Number of sequences in database: 37,866
Lambda K H
0.306 0.124 0.351
Gapped
Lambda K H
0.267 0.0410 0.140
Matrix: BLOSUM62
Gap Penalties: Existence: 11, Extension: 1
Number of Hits to DB: 28,279,624
Number of Sequences: 37866
Number of extensions: 1776872
Number of successful extensions: 44392
Number of sequences better than 10.0: 30
Number of HSP's better than 10.0 without gapping: 1078
Number of HSP's successfully gapped in prelim test: 2370
Number of HSP's that attempted gapping in prelim test: 14651
Number of HSP's gapped (non-prelim): 17602
length of query: 559
length of database: 18,247,518
effective HSP length: 107
effective length of query: 452
effective length of database: 14,195,856
effective search space: 6416526912
effective search space used: 6416526912
T: 11
A: 40
X1: 16 ( 7.1 bits)
X2: 38 (14.6 bits)
X3: 64 (24.7 bits)
S1: 43 (22.0 bits)
S2: 64 (29.3 bits)
Search results were obtained with NCBI BLAST and RefSeq entries.
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Guide to the Human Genome
Copyright © 2010 by Stewart Scherer. All rights reserved.