Search of human proteins with 21264359

Search of human proteins with 21264359

BLASTP 2.2.11 [Jun-05-2005]


Reference: Altschul, Stephen F., Thomas L. Madden, Alejandro A. Schaffer, 
Jinghui Zhang, Zheng Zhang, Webb Miller, and David J. Lipman (1997), 
"Gapped BLAST and PSI-BLAST: a new generation of protein database search
programs",  Nucleic Acids Res. 25:3389-3402.

Query= gi|21264359 mannan-binding lectin serine protease 1 isoform 2
precursor [Homo sapiens]
         (728 letters)

Database: hs.faa 
           37,866 sequences; 18,247,518 total letters

Searching..................................................done

                                                                 Score    E
Sequences producing significant alignments:                      (bits) Value

gi|21264359 mannan-binding lectin serine protease 1 isoform 2 pr...  1531   0.0  
gi|21264357 mannan-binding lectin serine protease 1 isoform 1 pr...  1070   0.0  
gi|73623026 mannan-binding lectin serine protease 1 isoform 3 [H...   777   0.0  
gi|21264363 mannan-binding lectin serine protease 2 isoform 1 pr...   612   e-175
gi|66347875 complement component 1, r subcomponent [Homo sapiens]     534   e-151
gi|4502495 complement component 1, s subcomponent precursor [Hom...   477   e-134
gi|41393602 complement component 1, s subcomponent precursor [Ho...   477   e-134
gi|21264361 mannan-binding lectin serine protease 2 isoform 2 pr...   207   4e-53
gi|7706083 complement component 1, r subcomponent-like precursor...   181   3e-45
gi|5453579 bone morphogenetic protein 1 isoform 3 precursor [Hom...   172   1e-42
gi|6912724 tolloid-like 2 [Homo sapiens]                              170   4e-42
gi|22547221 tolloid-like 1 [Homo sapiens]                             167   2e-41
gi|4503649 coagulation factor IX preproprotein [Homo sapiens]         159   9e-39
gi|4826762 haptoglobin isoform 1 preproprotein [Homo sapiens]         159   9e-39
gi|11415040 matriptase [Homo sapiens]                                 154   3e-37
gi|4502421 bone morphogenetic protein 1 isoform 1 precursor [Hom...   153   6e-37
gi|186910296 haptoglobin isoform 2 preproprotein [Homo sapiens]       150   4e-36
gi|5902808 bone morphogenetic protein 1 isoform 2 precursor [Hom...   147   3e-35
gi|78191798 plasma kallikrein B1 precursor [Homo sapiens]             145   1e-34
gi|110578663 hypothetical protein LOC203074 [Homo sapiens]            141   2e-33
gi|45580723 haptoglobin-related protein [Homo sapiens]                140   3e-33
gi|10518503 coagulation factor VII isoform b precursor [Homo sap...   138   2e-32
gi|4503645 coagulation factor VII isoform a precursor [Homo sapi...   138   2e-32
gi|23957702 transmembrane protease, serine 6 [Homo sapiens]           136   6e-32
gi|4506115 protein C [Homo sapiens]                                   135   1e-31
gi|33667063 transmembrane protease, serine 9 [Homo sapiens]           135   1e-31
gi|4506147 protease, serine, 2 preproprotein [Homo sapiens]           135   1e-31
gi|4506153 prostasin preproprotein [Homo sapiens]                     134   2e-31
gi|33695155 hepsin [Homo sapiens]                                     131   3e-30
gi|4504481 hepsin [Homo sapiens]                                      131   3e-30

>gi|21264359 mannan-binding lectin serine protease 1 isoform 2
           precursor [Homo sapiens]
          Length = 728

 Score = 1531 bits (3965), Expect = 0.0
 Identities = 728/728 (100%), Positives = 728/728 (100%)

Query: 1   MRWLLLYYALCFSLSKASAHTVELNNMFGQIQSPGYPDSYPSDSEVTWNITVPDGFRIKL 60
           MRWLLLYYALCFSLSKASAHTVELNNMFGQIQSPGYPDSYPSDSEVTWNITVPDGFRIKL
Sbjct: 1   MRWLLLYYALCFSLSKASAHTVELNNMFGQIQSPGYPDSYPSDSEVTWNITVPDGFRIKL 60

Query: 61  YFMHFNLESSYLCEYDYVKVETEDQVLATFCGRETTDTEQTPGQEVVLSPGSFMSITFRS 120
           YFMHFNLESSYLCEYDYVKVETEDQVLATFCGRETTDTEQTPGQEVVLSPGSFMSITFRS
Sbjct: 61  YFMHFNLESSYLCEYDYVKVETEDQVLATFCGRETTDTEQTPGQEVVLSPGSFMSITFRS 120

Query: 121 DFSNEERFTGFDAHYMAVDVDECKEREDEELSCDHYCHNYIGGYYCSCRFGYILHTDNRT 180
           DFSNEERFTGFDAHYMAVDVDECKEREDEELSCDHYCHNYIGGYYCSCRFGYILHTDNRT
Sbjct: 121 DFSNEERFTGFDAHYMAVDVDECKEREDEELSCDHYCHNYIGGYYCSCRFGYILHTDNRT 180

Query: 181 CRVECSDNLFTQRTGVITSPDFPNPYPKSSECLYTIELEEGFMVNLQFEDIFDIEDHPEV 240
           CRVECSDNLFTQRTGVITSPDFPNPYPKSSECLYTIELEEGFMVNLQFEDIFDIEDHPEV
Sbjct: 181 CRVECSDNLFTQRTGVITSPDFPNPYPKSSECLYTIELEEGFMVNLQFEDIFDIEDHPEV 240

Query: 241 PCPYDYIKIKVGPKVLGPFCGEKAPEPISTQSHSVLILFHSDNSGENRGWRLSYRAAGNE 300
           PCPYDYIKIKVGPKVLGPFCGEKAPEPISTQSHSVLILFHSDNSGENRGWRLSYRAAGNE
Sbjct: 241 PCPYDYIKIKVGPKVLGPFCGEKAPEPISTQSHSVLILFHSDNSGENRGWRLSYRAAGNE 300

Query: 301 CPELQPPVHGKIEPSQAKYFFKDQVLVSCDTGYKVLKDNVEMDTFQIECLKDGTWSNKIP 360
           CPELQPPVHGKIEPSQAKYFFKDQVLVSCDTGYKVLKDNVEMDTFQIECLKDGTWSNKIP
Sbjct: 301 CPELQPPVHGKIEPSQAKYFFKDQVLVSCDTGYKVLKDNVEMDTFQIECLKDGTWSNKIP 360

Query: 361 TCKIVDCRAPGELEHGLITFSTRNNLTTYKSEIKYSCQEPYYKMLNNNTGIYTCSAQGVW 420
           TCKIVDCRAPGELEHGLITFSTRNNLTTYKSEIKYSCQEPYYKMLNNNTGIYTCSAQGVW
Sbjct: 361 TCKIVDCRAPGELEHGLITFSTRNNLTTYKSEIKYSCQEPYYKMLNNNTGIYTCSAQGVW 420

Query: 421 MNKVLGRSLPTCLPECGQPSRSLPSLVKRIIGGRNAEPGLFPWQALIVVEDTSRVPNDKW 480
           MNKVLGRSLPTCLPECGQPSRSLPSLVKRIIGGRNAEPGLFPWQALIVVEDTSRVPNDKW
Sbjct: 421 MNKVLGRSLPTCLPECGQPSRSLPSLVKRIIGGRNAEPGLFPWQALIVVEDTSRVPNDKW 480

Query: 481 FGSGALLSASWILTAAHVLRSQRRDTTVIPVSKEHVTVYLGLHDVRDKSGAVNSSAARVV 540
           FGSGALLSASWILTAAHVLRSQRRDTTVIPVSKEHVTVYLGLHDVRDKSGAVNSSAARVV
Sbjct: 481 FGSGALLSASWILTAAHVLRSQRRDTTVIPVSKEHVTVYLGLHDVRDKSGAVNSSAARVV 540

Query: 541 LHPDFNIQNYNHDIALVQLQEPVPLGPHVMPVCLPRLEPEGPAPHMLGLVAGWGISNPNV 600
           LHPDFNIQNYNHDIALVQLQEPVPLGPHVMPVCLPRLEPEGPAPHMLGLVAGWGISNPNV
Sbjct: 541 LHPDFNIQNYNHDIALVQLQEPVPLGPHVMPVCLPRLEPEGPAPHMLGLVAGWGISNPNV 600

Query: 601 TVDEIISSGTRTLSDVLQYVKLPVVPHAECKTSYESRSGNYSVTENMFCAGYYEGGKDTC 660
           TVDEIISSGTRTLSDVLQYVKLPVVPHAECKTSYESRSGNYSVTENMFCAGYYEGGKDTC
Sbjct: 601 TVDEIISSGTRTLSDVLQYVKLPVVPHAECKTSYESRSGNYSVTENMFCAGYYEGGKDTC 660

Query: 661 LGDSGGAFVIFDDLSQRWVVQGLVSWGGPEECGSKQVYGVYTKVSNYVDWVWEQMGLPQS 720
           LGDSGGAFVIFDDLSQRWVVQGLVSWGGPEECGSKQVYGVYTKVSNYVDWVWEQMGLPQS
Sbjct: 661 LGDSGGAFVIFDDLSQRWVVQGLVSWGGPEECGSKQVYGVYTKVSNYVDWVWEQMGLPQS 720

Query: 721 VVEPQVER 728
           VVEPQVER
Sbjct: 721 VVEPQVER 728


>gi|21264357 mannan-binding lectin serine protease 1 isoform 1
           precursor [Homo sapiens]
          Length = 699

 Score = 1070 bits (2767), Expect = 0.0
 Identities = 532/726 (73%), Positives = 577/726 (79%), Gaps = 38/726 (5%)

Query: 1   MRWLLLYYALCFSLSKASAHTVELNNMFGQIQSPGYPDSYPSDSEVTWNITVPDGFRIKL 60
           MRWLLLYYALCFSLSKASAHTVELNNMFGQIQSPGYPDSYPSDSEVTWNITVPDGFRIKL
Sbjct: 1   MRWLLLYYALCFSLSKASAHTVELNNMFGQIQSPGYPDSYPSDSEVTWNITVPDGFRIKL 60

Query: 61  YFMHFNLESSYLCEYDYVKVETEDQVLATFCGRETTDTEQTPGQEVVLSPGSFMSITFRS 120
           YFMHFNLESSYLCEYDYVKVETEDQVLATFCGRETTDTEQTPGQEVVLSPGSFMSITFRS
Sbjct: 61  YFMHFNLESSYLCEYDYVKVETEDQVLATFCGRETTDTEQTPGQEVVLSPGSFMSITFRS 120

Query: 121 DFSNEERFTGFDAHYMAVDVDECKEREDEELSCDHYCHNYIGGYYCSCRFGYILHTDNRT 180
           DFSNEERFTGFDAHYMAVDVDECKEREDEELSCDHYCHNYIGGYYCSCRFGYILHTDNRT
Sbjct: 121 DFSNEERFTGFDAHYMAVDVDECKEREDEELSCDHYCHNYIGGYYCSCRFGYILHTDNRT 180

Query: 181 CRVECSDNLFTQRTGVITSPDFPNPYPKSSECLYTIELEEGFMVNLQFEDIFDIEDHPEV 240
           CRVECSDNLFTQRTGVITSPDFPNPYPKSSECLYTIELEEGFMVNLQFEDIFDIEDHPEV
Sbjct: 181 CRVECSDNLFTQRTGVITSPDFPNPYPKSSECLYTIELEEGFMVNLQFEDIFDIEDHPEV 240

Query: 241 PCPYDYIKIKVGPKVLGPFCGEKAPEPISTQSHSVLILFHSDNSGENRGWRLSYRAAGNE 300
           PCPYDYIKIKVGPKVLGPFCGEKAPEPISTQSHSVLILFHSDNSGENRGWRLSYRAAGNE
Sbjct: 241 PCPYDYIKIKVGPKVLGPFCGEKAPEPISTQSHSVLILFHSDNSGENRGWRLSYRAAGNE 300

Query: 301 CPELQPPVHGKIEPSQAKYFFKDQVLVSCDTGYKVLKDNVEMDTFQIECLKDGTWSNKIP 360
           CPELQPPVHGKIEPSQAKYFFKDQVLVSCDTGYKVLKDNVEMDTFQIECLKDGTWSNKIP
Sbjct: 301 CPELQPPVHGKIEPSQAKYFFKDQVLVSCDTGYKVLKDNVEMDTFQIECLKDGTWSNKIP 360

Query: 361 TCKIVDCRAPGELEHGLITFSTRNNLTTYKSEIKYSCQEPYYKMLNNNTGIYTCSAQGVW 420
           TCKIVDCRAPGELEHGLITFSTRNNLTTYKSEIKYSCQEPYYKMLNNNTGIYTCSAQGVW
Sbjct: 361 TCKIVDCRAPGELEHGLITFSTRNNLTTYKSEIKYSCQEPYYKMLNNNTGIYTCSAQGVW 420

Query: 421 MNKVLGRSLPTCLPECGQPSRSLPSLVKRIIGGRNAEPGLFPWQALIVVEDTSRVPNDKW 480
           MNKVLGRSLPTCLP CG P  S   L+ RI  GR A+ G  PW A++     S + N + 
Sbjct: 421 MNKVLGRSLPTCLPVCGLPKFS-RKLMARIFNGRPAQKGTTPWIAML-----SHL-NGQP 473

Query: 481 FGSGALLSASWILTAAHVLRSQ-------RRDTTVIPVSKEHVTVYLGLH-DVRDKSGAV 532
           F  G+LL +SWI+TAAH L           RD+ ++  S     + LG H  +R      
Sbjct: 474 FCGGSLLGSSWIVTAAHCLHQSLDPEDPTLRDSDLL--SPSDFKIILGKHWRLRSDENEQ 531

Query: 533 NSSAARVVLHPDFNIQNYNHDIALVQLQEPVPLGPHVMPVCLPRLEPEGPAPH-MLGLVA 591
           +       LHP ++   + +D+ALV+L E   L   VMP+CL    PEGP     + +V+
Sbjct: 532 HLGVKHTTLHPQYDPNTFENDVALVELLESPVLNAFVMPICL----PEGPQQEGAMVIVS 587

Query: 592 GWGISNPNVTVDEIISSGTRTLSDVLQYVKLPVVPHAECKTSYESRSGNYSVTENMFCAG 651
           GWG                +   + L  +++P+V H+ C+ +Y        VT +M CAG
Sbjct: 588 GWG------------KQFLQRFPETLMEIEIPIVDHSTCQKAYAPL--KKKVTRDMICAG 633

Query: 652 YYEGGKDTCLGDSGGAFVIFDDLSQRWVVQGLVSWGGPEECGSKQVYGVYTKVSNYVDWV 711
             EGGKD C GDSGG  V  +    +W + G VSWG  ++CG K  YGVY+ + +  DW+
Sbjct: 634 EKEGGKDACAGDSGGPMVTLNRERGQWYLVGTVSWG--DDCGKKDRYGVYSYIHHNKDWI 691

Query: 712 WEQMGL 717
               G+
Sbjct: 692 QRVTGV 697


>gi|73623026 mannan-binding lectin serine protease 1 isoform 3 [Homo
           sapiens]
          Length = 380

 Score =  777 bits (2007), Expect = 0.0
 Identities = 366/379 (96%), Positives = 369/379 (97%)

Query: 1   MRWLLLYYALCFSLSKASAHTVELNNMFGQIQSPGYPDSYPSDSEVTWNITVPDGFRIKL 60
           MRWLLLYYALCFSLSKASAHTVELNNMFGQIQSPGYPDSYPSDSEVTWNITVPDGFRIKL
Sbjct: 1   MRWLLLYYALCFSLSKASAHTVELNNMFGQIQSPGYPDSYPSDSEVTWNITVPDGFRIKL 60

Query: 61  YFMHFNLESSYLCEYDYVKVETEDQVLATFCGRETTDTEQTPGQEVVLSPGSFMSITFRS 120
           YFMHFNLESSYLCEYDYVKVETEDQVLATFCGRETTDTEQTPGQEVVLSPGSFMSITFRS
Sbjct: 61  YFMHFNLESSYLCEYDYVKVETEDQVLATFCGRETTDTEQTPGQEVVLSPGSFMSITFRS 120

Query: 121 DFSNEERFTGFDAHYMAVDVDECKEREDEELSCDHYCHNYIGGYYCSCRFGYILHTDNRT 180
           DFSNEERFTGFDAHYMAVDVDECKEREDEELSCDHYCHNYIGGYYCSCRFGYILHTDNRT
Sbjct: 121 DFSNEERFTGFDAHYMAVDVDECKEREDEELSCDHYCHNYIGGYYCSCRFGYILHTDNRT 180

Query: 181 CRVECSDNLFTQRTGVITSPDFPNPYPKSSECLYTIELEEGFMVNLQFEDIFDIEDHPEV 240
           CRVECSDNLFTQRTGVITSPDFPNPYPKSSECLYTIELEEGFMVNLQFEDIFDIEDHPEV
Sbjct: 181 CRVECSDNLFTQRTGVITSPDFPNPYPKSSECLYTIELEEGFMVNLQFEDIFDIEDHPEV 240

Query: 241 PCPYDYIKIKVGPKVLGPFCGEKAPEPISTQSHSVLILFHSDNSGENRGWRLSYRAAGNE 300
           PCPYDYIKIKVGPKVLGPFCGEKAPEPISTQSHSVLILFHSDNSGENRGWRLSYRAAGNE
Sbjct: 241 PCPYDYIKIKVGPKVLGPFCGEKAPEPISTQSHSVLILFHSDNSGENRGWRLSYRAAGNE 300

Query: 301 CPELQPPVHGKIEPSQAKYFFKDQVLVSCDTGYKVLKDNVEMDTFQIECLKDGTWSNKIP 360
           CPELQPPVHGKIEPSQAKYFFKDQVLVSCDTGYKVLKDNVEMDTFQIECLKDGTWSNKIP
Sbjct: 301 CPELQPPVHGKIEPSQAKYFFKDQVLVSCDTGYKVLKDNVEMDTFQIECLKDGTWSNKIP 360

Query: 361 TCKIVDCRAPGELEHGLIT 379
           TCK  +     EL+   +T
Sbjct: 361 TCKKNEIDLESELKSEQVT 379


>gi|21264363 mannan-binding lectin serine protease 2 isoform 1
           precursor [Homo sapiens]
          Length = 686

 Score =  612 bits (1579), Expect = e-175
 Identities = 307/714 (42%), Positives = 431/714 (60%), Gaps = 38/714 (5%)

Query: 1   MRWLLLYYALCFSLSKASAHTVELNNMFGQIQSPGYPDSYPSDSEVTWNITVPDGFRIKL 60
           MR L L   LC S++           +FG++ SPG+P  Y +D E  W +T P G+R++L
Sbjct: 1   MRLLTLLGLLCGSVATPLGPKWP-EPVFGRLASPGFPGEYANDQERRWTLTAPPGYRLRL 59

Query: 61  YFMHFNLESSYLCEYDYVKVETEDQVLATFCGRETTDTEQTPGQEVVLSPGSFMSITFRS 120
           YF HF+LE S+LCEYD+VK+ +  +VLAT CG+E+TDTE+ PG++   S GS + ITFRS
Sbjct: 60  YFTHFDLELSHLCEYDFVKLSSGAKVLATLCGQESTDTERAPGKDTFYSLGSSLDITFRS 119

Query: 121 DFSNEERFTGFDAHYMAVDVDECKEREDEELSCDHYCHNYIGGYYCSCRFGYILHTDNRT 180
           D+SNE+ FTGF+A Y A D+DEC+    E  +CDH+CHN++GG+YCSCR GY+LH + RT
Sbjct: 120 DYSNEKPFTGFEAFYAAEDIDECQVAPGEAPTCDHHCHNHLGGFYCSCRAGYVLHRNKRT 179

Query: 181 CRVECSDNLFTQRTGVITSPDFPNPYPKSSECLYTIELEEGFMVNLQFEDIFDIEDHPEV 240
           C   CS  +FTQR+G ++SP++P PYPK S C Y+I LEEGF V L F + FD+E HPE 
Sbjct: 180 CSALCSGQVFTQRSGELSSPEYPRPYPKLSSCTYSISLEEGFSVILDFVESFDVETHPET 239

Query: 241 PCPYDYIKIKVGPKVLGPFCGEKAPEPISTQSHSVLILFHSDNSGENRGWRLSYRAAGNE 300
            CPYD++KI+   +  GPFCG+  P  I T+S++V I F +D SG++ GW++ Y +    
Sbjct: 240 LCPYDFLKIQTDREEHGPFCGKTLPHRIETKSNTVTITFVTDESGDHTGWKIHYTSTAQP 299

Query: 301 CPELQPPVHGKIEPSQAKYFFKDQVLVSCDTGYKVLKDNVEMDTFQIECLKDGTWSNKIP 360
           CP    P +G + P QAKY  KD   + C+TGY++L+ ++ + +F   C KDG+W   +P
Sbjct: 300 CPYPMAPPNGHVSPVQAKYILKDSFSIFCETGYELLQGHLPLKSFTAVCQKDGSWDRPMP 359

Query: 361 TCKIVDCRAPGELEHGLITFSTRNNLTTYKSEIKYSCQEPYYKMLNNNTGIYTCSAQGVW 420
            C IVDC  P +L  G + + T   +TTYK+ I+YSC+E +Y M   N G Y C A G W
Sbjct: 360 ACSIVDCGPPDDLPSGRVEYITGPGVTTYKAVIQYSCEETFYTM-KVNDGKYVCEADGFW 418

Query: 421 MNKVLGRSLPTCLPECGQPSRSLPSLVKRIIGGRNAEPGLFPWQALIVVEDTSRVPNDKW 480
            +    +SLP C P CG  +R+      RI GG+ A+PG FPWQ LI+   T+       
Sbjct: 419 TSSKGEKSLPVCEPVCGLSARTTGG---RIYGGQKAKPGDFPWQVLILGGTTA------- 468

Query: 481 FGSGALLSASWILTAAHVLRSQRRDTTVIPVSKEHVTVYLGLHDVRDKSGAVNSSAARVV 540
             +GALL  +W+LTAAH +  Q+ D + + + +      L  H  +  S A       V 
Sbjct: 469 --AGALLYDNWVLTAAHAVYEQKHDASALDI-RMGTLKRLSPHYTQAWSEA-------VF 518

Query: 541 LHPDF-NIQNYNHDIALVQLQEPVPLGPHVMPVCLPRLEPEG-PAPHMLGLVAGWGISNP 598
           +H  + +   +++DIAL++L   V +  ++ P+CLPR E E       +G  +GWG++  
Sbjct: 519 IHEGYTHDAGFDNDIALIKLNNKVVINSNITPICLPRKEAESFMRTDDIGTASGWGLTQR 578

Query: 599 NVTVDEIISSGTRTLSDVLQYVKLPVVPHAECKTSYESRS-GNYSVTENMFCAGYYEGGK 657
                         L+  L YV +P+V H +C  +YE       SVT NM CAG   GGK
Sbjct: 579 GF------------LARNLMYVDIPIVDHQKCTAAYEKPPYPRGSVTANMLCAGLESGGK 626

Query: 658 DTCLGDSGGAFVIFDDLSQRWVVQGLVSWGGPEECGSKQVYGVYTKVSNYVDWV 711
           D+C GDSGGA V  D  ++RW V G+VSWG    CG    YGVYTKV NY+ W+
Sbjct: 627 DSCRGDSGGALVFLDSETERWFVGGIVSWGS-MNCGEAGQYGVYTKVINYIPWI 679


>gi|66347875 complement component 1, r subcomponent [Homo sapiens]
          Length = 705

 Score =  534 bits (1375), Expect = e-151
 Identities = 283/733 (38%), Positives = 411/733 (56%), Gaps = 56/733 (7%)

Query: 5   LLYYALCFSLSKASAHTVELNNMFGQIQSPGYPDSYPSDSEVTWNITVPDGFRIKLYFMH 64
           LLY  +     +A         +FG++ SP +P  YP++ E T  ITVP G+R+KL F  
Sbjct: 3   LLYLLVPALFCRAGGSIPIPQKLFGEVTSPLFPKPYPNNFETTTVITVPTGYRVKLVFQQ 62

Query: 65  FNLESSYLCEYDYVKVETEDQVLATFCGRETTDTEQTPGQEVVLSPGSFMSITFRSDFSN 124
           F+LE S  C YDYVK+  + + L  FCG+  +     PG++  +S G+ M +TF +DFSN
Sbjct: 63  FDLEPSEGCFYDYVKISADKKSLGRFCGQLGSPLGNPPGKKEFMSQGNKMLLTFHTDFSN 122

Query: 125 EERFT-----GFDAHYMAVDVDECKER-----EDEELSCDHYCHNYIGGYYCSCRFGYIL 174
           EE  T     GF A+Y AVD+DEC  R     ED +  C H CHNY+GGY+CSCR GY L
Sbjct: 123 EENGTIMFYKGFLAYYQAVDLDECASRSKLGEEDPQPQCQHLCHNYVGGYFCSCRPGYEL 182

Query: 175 HTDNRTCRVECSDNLFTQRTGVITSPDFPNPYPKSSECLYTIELEEGFMVNLQFEDIFDI 234
             D  +C+ ECS  L+T+ +G I+S ++P  YP    C Y+I +E G  ++L+F + FDI
Sbjct: 183 QEDRHSCQAECSSELYTEASGYISSLEYPRSYPPDLRCNYSIRVERGLTLHLKFLEPFDI 242

Query: 235 EDHPEVPCPYDYIKIKVGPKVLGPFCGEKAPEPISTQSHSVLILFHSDNSGENRGWRLSY 294
           +DH +V CPYD ++I    K +G FCG++ P  + T S++V +LF +D SG++RGW+L Y
Sbjct: 243 DDHQQVHCPYDQLQIYANGKNIGEFCGKQRPPDLDTSSNAVDLLFFTDESGDSRGWKLRY 302

Query: 295 RAAGNECPELQPPVHGK---IEPSQAKYFFKDQVLVSCDTGYKVLKDNVEMDTFQIECLK 351
                +CP  QP    +   I+  Q +Y F+D  + +C  GY++++ N  + +F   C  
Sbjct: 303 TTEIIKCP--QPKTLDEFTIIQNLQPQYQFRDYFIATCKQGYQLIEGNQVLHSFTAVCQD 360

Query: 352 DGTWSNKIPTCKIVDCRAPGELEHGLITFSTRNNLTTYKSEIKYSCQEPYYKM------L 405
           DGTW   +P CKI DC  P  L +G   ++T   + TYK+ I+Y C EPYYKM       
Sbjct: 361 DGTWHRAMPRCKIKDCGQPRNLPNGDFRYTTTMGVNTYKARIQYYCHEPYYKMQTRAGSR 420

Query: 406 NNNTGIYTCSAQGVWMNKVLGRSLPTCLPECGQPSRSLPSLVKRIIGGRNAEPGLFPWQA 465
            +  G+YTC+AQG+W N+  G  +P CLP CG+P   +    +RIIGG+ A+ G FPWQ 
Sbjct: 421 ESEQGVYTCTAQGIWKNEQKGEKIPRCLPVCGKPVNPVEQR-QRIIGGQKAKMGNFPWQV 479

Query: 466 LIVVEDTSRVPNDKWFGSGALLSASWILTAAHVLRSQRRDTTVIPVSKEHVTVYLGLHDV 525
              +            G GALL   WILTAAH L  +  +      S   + V+LG  +V
Sbjct: 480 FTNIHGR---------GGGALLGDRWILTAAHTLYPKEHEAQ----SNASLDVFLGHTNV 526

Query: 526 RDKSGAVNSSAARVVLHPDF---NIQNYNHDIALVQLQEPVPLGPHVMPVCLPRLEPEGP 582
            +     N    RV +HPD+      N+  DIAL++L+  V LGP+++P+CLP  +    
Sbjct: 527 EELMKLGNHPIRRVSVHPDYRQDESYNFEGDIALLELENSVTLGPNLLPICLPDNDTFYD 586

Query: 583 APHMLGLVAGWGISNPNVTVDEIISSGTRTLSDVLQYVKLPVVPHAECKTSYESRSGNYS 642
              ++G V+G+G+    +  D             L++V+LPV     C+     ++    
Sbjct: 587 L-GLMGYVSGFGVMEEKIAHD-------------LRFVRLPVANPQACENWLRGKNRMDV 632

Query: 643 VTENMFCAGYYEGGKDTCLGDSGGAFVIFDDLSQRWVVQGLVSWGGPEECGSKQVYGVYT 702
            ++NMFCAG+    +D C GDSGG F + D  + RWV  G+VSWG     G  + YG YT
Sbjct: 633 FSQNMFCAGHPSLKQDACQGDSGGVFAVRDPNTDRWVATGIVSWG----IGCSRGYGFYT 688

Query: 703 KVSNYVDWVWEQM 715
           KV NYVDW+ ++M
Sbjct: 689 KVLNYVDWIKKEM 701


>gi|4502495 complement component 1, s subcomponent precursor [Homo
           sapiens]
          Length = 688

 Score =  477 bits (1228), Expect = e-134
 Identities = 274/724 (37%), Positives = 401/724 (55%), Gaps = 66/724 (9%)

Query: 11  CFSLSKASAHTVELNNMFGQIQSPGYPDSYPSDSEVTWNITVPDGFRIKLYFMHFNLESS 70
           C  L    A       M+G+I SP YP +YPS+ E +W+I VP+G+ I LYF H ++E S
Sbjct: 3   CIVLFSLLAWVYAEPTMYGEILSPNYPQAYPSEVEKSWDIEVPEGYGIHLYFTHLDIELS 62

Query: 71  YLCEYDYVKVETEDQVLATFCGRETTDTEQTPGQEVVLSPGSFMSITFRSDFSNEERFTG 130
             C YD V++ + D      CG+ +++   +P  E    P + + + F+SDFSNEERFTG
Sbjct: 63  ENCAYDSVQIISGDTEEGRLCGQRSSNNPHSPIVEEFQVPYNKLQVIFKSDFSNEERFTG 122

Query: 131 FDAHYMAVDVDECKEREDEELSCDHYCHNYIGGYYCSCRFGYILHTDNRTCRVECSDNLF 190
           F A+Y+A D++EC +  D  + C H+C+N+IGGY+CSC   Y LH D + C V CS ++F
Sbjct: 123 FAAYYVATDINECTDFVD--VPCSHFCNNFIGGYFCSCPPEYFLHDDMKNCGVNCSGDVF 180

Query: 191 TQRTGVITSPDFPNPYPKSSECLYTIELEEGF--MVNLQFEDIFDIEDHPEVPCPYDYIK 248
           T   G I SP++P PYP++S C Y I LE+GF  +V L+ ED FD+E         D + 
Sbjct: 181 TALIGEIASPNYPKPYPENSRCEYQIRLEKGFQVVVTLRRED-FDVEAADSAGNCLDSLV 239

Query: 249 IKVGPKVLGPFCGEKAPEP--ISTQSHSVLILFHSDNSGENRGWRLSYRAAGNECPELQP 306
              G +  GP+CG   P P  I T+S+++ I+F +D +G+ +GW+L Y      CP+   
Sbjct: 240 FVAGDRQFGPYCGHGFPGPLNIETKSNALDIIFQTDLTGQKKGWKLRYHGDPMPCPKEDT 299

Query: 307 PVHGKIEPSQAKYFFKDQVLVSCDTGYKVLKDNVEMDTFQIECLKDGTWSNKIPTCKIVD 366
           P +   EP++AKY F+D V ++C  G++V++  V   +F   C  +G WSN    C+ VD
Sbjct: 300 P-NSVWEPAKAKYVFRDVVQITCLDGFEVVEGRVGATSFYSTCQSNGKWSNSKLKCQPVD 358

Query: 367 CRAPGELEHGLITFSTRNNLTTYKSEIKYSCQEPYYKMLNNNTGIYTCSAQGVWMNKVLG 426
           C  P  +E+G +        T + S I+Y+C+EPYY M N   G Y C+  G W+N+VLG
Sbjct: 359 CGIPESIENGKV---EDPESTLFGSVIRYTCEEPYYYMENGGGGEYHCAGNGSWVNEVLG 415

Query: 427 RSLPTCLPECGQPSRSLPSLVKRIIGGRNAEPGLFPWQALIVVEDTSRVPNDKWFGSGAL 486
             LP C+P CG P        +RIIGG +A+   FPWQ            ++ W G GAL
Sbjct: 416 PELPKCVPVCGVPREPFEE-KQRIIGGSDADIKNFPWQVFF---------DNPWAG-GAL 464

Query: 487 LSASWILTAAHVLRSQRRDTTVIPVSKEHVTVYLGLHDVRDKSGAVNS--SAARVVLHPD 544
           ++  W+LTAAHV+   R             T+Y+G   V+    A +   +   V +HP 
Sbjct: 465 INEYWVLTAAHVVEGNREP-----------TMYVGSTSVQTSRLAKSKMLTPEHVFIHPG 513

Query: 545 FNI-------QNYNHDIALVQLQEPVPLGPHVMPVCLPRLEPE-GPAPHMLGLVAGWGIS 596
           + +        N+++DIALV+L++PV +GP V P+CLP    +       LGL++GWG  
Sbjct: 514 WKLLEVPEGRTNFDNDIALVRLKDPVKMGPTVSPICLPGTSSDYNLMDGDLGLISGWG-- 571

Query: 597 NPNVTVDEIISSGTRTLSDVLQYVKLPVVPHAECK-TSYESRSGN---YSVTENMFCAGY 652
                      +  R  +  L+  +LPV P  +CK    E  + +   Y  T NM CAG 
Sbjct: 572 ----------RTEKRDRAVRLKAARLPVAPLRKCKEVKVEKPTADAEAYVFTPNMICAG- 620

Query: 653 YEGGKDTCLGDSGGAFVIFDDLSQ-RWVVQGLVSWGGPEECGSKQVYGVYTKVSNYVDWV 711
            E G D+C GDSGGAF + D   + ++   GLVSWG   +CG+   YG+YT+V NYVDW+
Sbjct: 621 GEKGMDSCKGDSGGAFAVQDPNDKTKFYAAGLVSWG--PQCGT---YGLYTRVKNYVDWI 675

Query: 712 WEQM 715
            + M
Sbjct: 676 MKTM 679


>gi|41393602 complement component 1, s subcomponent precursor [Homo
           sapiens]
          Length = 688

 Score =  477 bits (1228), Expect = e-134
 Identities = 274/724 (37%), Positives = 401/724 (55%), Gaps = 66/724 (9%)

Query: 11  CFSLSKASAHTVELNNMFGQIQSPGYPDSYPSDSEVTWNITVPDGFRIKLYFMHFNLESS 70
           C  L    A       M+G+I SP YP +YPS+ E +W+I VP+G+ I LYF H ++E S
Sbjct: 3   CIVLFSLLAWVYAEPTMYGEILSPNYPQAYPSEVEKSWDIEVPEGYGIHLYFTHLDIELS 62

Query: 71  YLCEYDYVKVETEDQVLATFCGRETTDTEQTPGQEVVLSPGSFMSITFRSDFSNEERFTG 130
             C YD V++ + D      CG+ +++   +P  E    P + + + F+SDFSNEERFTG
Sbjct: 63  ENCAYDSVQIISGDTEEGRLCGQRSSNNPHSPIVEEFQVPYNKLQVIFKSDFSNEERFTG 122

Query: 131 FDAHYMAVDVDECKEREDEELSCDHYCHNYIGGYYCSCRFGYILHTDNRTCRVECSDNLF 190
           F A+Y+A D++EC +  D  + C H+C+N+IGGY+CSC   Y LH D + C V CS ++F
Sbjct: 123 FAAYYVATDINECTDFVD--VPCSHFCNNFIGGYFCSCPPEYFLHDDMKNCGVNCSGDVF 180

Query: 191 TQRTGVITSPDFPNPYPKSSECLYTIELEEGF--MVNLQFEDIFDIEDHPEVPCPYDYIK 248
           T   G I SP++P PYP++S C Y I LE+GF  +V L+ ED FD+E         D + 
Sbjct: 181 TALIGEIASPNYPKPYPENSRCEYQIRLEKGFQVVVTLRRED-FDVEAADSAGNCLDSLV 239

Query: 249 IKVGPKVLGPFCGEKAPEP--ISTQSHSVLILFHSDNSGENRGWRLSYRAAGNECPELQP 306
              G +  GP+CG   P P  I T+S+++ I+F +D +G+ +GW+L Y      CP+   
Sbjct: 240 FVAGDRQFGPYCGHGFPGPLNIETKSNALDIIFQTDLTGQKKGWKLRYHGDPMPCPKEDT 299

Query: 307 PVHGKIEPSQAKYFFKDQVLVSCDTGYKVLKDNVEMDTFQIECLKDGTWSNKIPTCKIVD 366
           P +   EP++AKY F+D V ++C  G++V++  V   +F   C  +G WSN    C+ VD
Sbjct: 300 P-NSVWEPAKAKYVFRDVVQITCLDGFEVVEGRVGATSFYSTCQSNGKWSNSKLKCQPVD 358

Query: 367 CRAPGELEHGLITFSTRNNLTTYKSEIKYSCQEPYYKMLNNNTGIYTCSAQGVWMNKVLG 426
           C  P  +E+G +        T + S I+Y+C+EPYY M N   G Y C+  G W+N+VLG
Sbjct: 359 CGIPESIENGKV---EDPESTLFGSVIRYTCEEPYYYMENGGGGEYHCAGNGSWVNEVLG 415

Query: 427 RSLPTCLPECGQPSRSLPSLVKRIIGGRNAEPGLFPWQALIVVEDTSRVPNDKWFGSGAL 486
             LP C+P CG P        +RIIGG +A+   FPWQ            ++ W G GAL
Sbjct: 416 PELPKCVPVCGVPREPFEE-KQRIIGGSDADIKNFPWQVFF---------DNPWAG-GAL 464

Query: 487 LSASWILTAAHVLRSQRRDTTVIPVSKEHVTVYLGLHDVRDKSGAVNS--SAARVVLHPD 544
           ++  W+LTAAHV+   R             T+Y+G   V+    A +   +   V +HP 
Sbjct: 465 INEYWVLTAAHVVEGNREP-----------TMYVGSTSVQTSRLAKSKMLTPEHVFIHPG 513

Query: 545 FNI-------QNYNHDIALVQLQEPVPLGPHVMPVCLPRLEPE-GPAPHMLGLVAGWGIS 596
           + +        N+++DIALV+L++PV +GP V P+CLP    +       LGL++GWG  
Sbjct: 514 WKLLEVPEGRTNFDNDIALVRLKDPVKMGPTVSPICLPGTSSDYNLMDGDLGLISGWG-- 571

Query: 597 NPNVTVDEIISSGTRTLSDVLQYVKLPVVPHAECK-TSYESRSGN---YSVTENMFCAGY 652
                      +  R  +  L+  +LPV P  +CK    E  + +   Y  T NM CAG 
Sbjct: 572 ----------RTEKRDRAVRLKAARLPVAPLRKCKEVKVEKPTADAEAYVFTPNMICAG- 620

Query: 653 YEGGKDTCLGDSGGAFVIFDDLSQ-RWVVQGLVSWGGPEECGSKQVYGVYTKVSNYVDWV 711
            E G D+C GDSGGAF + D   + ++   GLVSWG   +CG+   YG+YT+V NYVDW+
Sbjct: 621 GEKGMDSCKGDSGGAFAVQDPNDKTKFYAAGLVSWG--PQCGT---YGLYTRVKNYVDWI 675

Query: 712 WEQM 715
            + M
Sbjct: 676 MKTM 679


>gi|21264361 mannan-binding lectin serine protease 2 isoform 2
           precursor [Homo sapiens]
          Length = 185

 Score =  207 bits (526), Expect = 4e-53
 Identities = 93/181 (51%), Positives = 128/181 (70%), Gaps = 1/181 (0%)

Query: 1   MRWLLLYYALCFSLSKASAHTVELNNMFGQIQSPGYPDSYPSDSEVTWNITVPDGFRIKL 60
           MR L L   LC S++           +FG++ SPG+P  Y +D E  W +T P G+R++L
Sbjct: 1   MRLLTLLGLLCGSVATPLGPKWP-EPVFGRLASPGFPGEYANDQERRWTLTAPPGYRLRL 59

Query: 61  YFMHFNLESSYLCEYDYVKVETEDQVLATFCGRETTDTEQTPGQEVVLSPGSFMSITFRS 120
           YF HF+LE S+LCEYD+VK+ +  +VLAT CG+E+TDTE+ PG++   S GS + ITFRS
Sbjct: 60  YFTHFDLELSHLCEYDFVKLSSGAKVLATLCGQESTDTERAPGKDTFYSLGSSLDITFRS 119

Query: 121 DFSNEERFTGFDAHYMAVDVDECKEREDEELSCDHYCHNYIGGYYCSCRFGYILHTDNRT 180
           D+SNE+ FTGF+A Y A D+DEC+    E  +CDH+CHN++GG+YCSCR GY+LH + RT
Sbjct: 120 DYSNEKPFTGFEAFYAAEDIDECQVAPGEAPTCDHHCHNHLGGFYCSCRAGYVLHRNKRT 179

Query: 181 C 181
           C
Sbjct: 180 C 180



 Score = 49.7 bits (117), Expect = 1e-05
 Identities = 40/119 (33%), Positives = 55/119 (46%), Gaps = 16/119 (13%)

Query: 195 GVITSPDFPNPYPKSSECLYTIELEEGFMVNLQFEDIFDIE-DHPEVPCPYDYIKIKVGP 253
           G + SP FP  Y    E  +T+    G+ + L F   FD+E  H    C YD++K+  G 
Sbjct: 28  GRLASPGFPGEYANDQERRWTLTAPPGYRLRLYFTH-FDLELSHL---CEYDFVKLSSGA 83

Query: 254 KVLGPFCG------EKAP--EPISTQSHSVLILFHSDNSGEN--RGWRLSYRAAG-NEC 301
           KVL   CG      E+AP  +   +   S+ I F SD S E    G+   Y A   +EC
Sbjct: 84  KVLATLCGQESTDTERAPGKDTFYSLGSSLDITFRSDYSNEKPFTGFEAFYAAEDIDEC 142


>gi|7706083 complement component 1, r subcomponent-like precursor
           [Homo sapiens]
          Length = 487

 Score =  181 bits (458), Expect = 3e-45
 Identities = 110/324 (33%), Positives = 163/324 (50%), Gaps = 36/324 (11%)

Query: 391 SEIKYSCQEPYYKMLNNNTGIYTCSAQGVWMNKVLGRSLPTCLPECGQPSRSLPSLVKRI 450
           ++++  CQEPYY+      G  TC+  G W ++  G  +  C+P CG+P   +    +  
Sbjct: 189 AKVQNHCQEPYYQAAA--AGALTCATPGTWKDRQDGEEVLQCMPVCGRPVTPIAQN-QTT 245

Query: 451 IGGRNAEPGLFPWQALIVVEDTSRVPNDKWFGSGALLSASWILTAAHVLRSQRRDTTVIP 510
           +G   A+ G FPWQA   +            G GALL   WILTAAH +  +    +V  
Sbjct: 246 LGSSRAKLGNFPWQAFTSIHGR---------GGGALLGDRWILTAAHTVYPK---DSVSL 293

Query: 511 VSKEHVTVYLGLHDVRDKSGAVNSSAARVVLHPDFN---IQNYNHDIALVQLQEPVPLGP 567
              + V V+LG   + +     N    RVV+HPD+      N++ DIAL++LQ  +PLGP
Sbjct: 294 RKNQSVNVFLGHTAIDEMLKLGNHPVHRVVVHPDYRQNESHNFSGDIALLELQHSIPLGP 353

Query: 568 HVMPVCLPRLEPEGPAPHMLGLVAGWGISNPNVTVDEIISSGTRTLSDVLQYVKLPVVPH 627
           +V+PVCLP  E    +  +LG V+G+G+    +T +             L+Y +LPV P 
Sbjct: 354 NVLPVCLPDNETLYRSG-LLGYVSGFGMEMGWLTTE-------------LKYSRLPVAPR 399

Query: 628 AECKTSYESRSGNYSVTENMFCAGYYEGGKDTCLGDSGGAFVIFDDLSQRWVVQGLVSWG 687
             C    + R      ++NMFC G        C GDSG  +V++D+ +  WV  G+VSWG
Sbjct: 400 EACNAWLQKRQRPEVFSDNMFCVGDETQRHSVCQGDSGSVYVVWDNHAHHWVATGIVSWG 459

Query: 688 GPEECGSKQVYGVYTKVSNYVDWV 711
                G  + Y  YTKV +YVDW+
Sbjct: 460 ----IGCGEGYDFYTKVLSYVDWI 479



 Score = 74.3 bits (181), Expect = 4e-13
 Identities = 47/145 (32%), Positives = 73/145 (50%), Gaps = 6/145 (4%)

Query: 1   MRWLLLYYALCFSLSKASAHTVELNNMFGQIQSPGYPDSYPSDSEVTWNITVPDGFRIKL 60
           M WLLL+  L    ++ S    +   +  Q+ SPGYP+ Y    E + +I  P+GF ++L
Sbjct: 24  MWWLLLWGVLQACPTRGSVLLAQ--ELPQQLTSPGYPEPYGKGQESSTDIKAPEGFAVRL 81

Query: 61  YFMHFNLESSYLCEYDYVKVETEDQVLATFCGRETTDTEQTPGQEVVLSPGSFMSITFRS 120
            F  F+LE S  C  D V +       + FCG++ +   + PGQ   +S G  + +TFR+
Sbjct: 82  VFQDFDLEPSQDCAGDSVTISFVGSDPSQFCGQQGSPLGRPPGQREFVSSGRSLRLTFRT 141

Query: 121 DFSNEER----FTGFDAHYMAVDVD 141
             S+E +      GF A Y  V V+
Sbjct: 142 QPSSENKTAHLHKGFLALYQTVAVN 166



 Score = 47.0 bits (110), Expect = 6e-05
 Identities = 31/100 (31%), Positives = 44/100 (44%), Gaps = 11/100 (11%)

Query: 197 ITSPDFPNPYPKSSECLYTIELEEGFMVNLQFEDIFDIEDHPEVPCPYDYIKIKVGPKVL 256
           +TSP +P PY K  E    I+  EGF V L F+D FD+E  P   C  D + I       
Sbjct: 52  LTSPGYPEPYGKGQESSTDIKAPEGFAVRLVFQD-FDLE--PSQDCAGDSVTISFVGSDP 108

Query: 257 GPFCGEK--------APEPISTQSHSVLILFHSDNSGENR 288
             FCG++              +   S+ + F +  S EN+
Sbjct: 109 SQFCGQQGSPLGRPPGQREFVSSGRSLRLTFRTQPSSENK 148


>gi|5453579 bone morphogenetic protein 1 isoform 3 precursor [Homo
           sapiens]
          Length = 986

 Score =  172 bits (436), Expect = 1e-42
 Identities = 96/279 (34%), Positives = 146/279 (52%), Gaps = 25/279 (8%)

Query: 24  LNNMFGQIQSPGYPDSYPSDSEVTWNITVPDGFRIKLYFMHFNLESSYLCEYDYVKVET- 82
           L  + G I SPG+P  YP +    W +  P  +RI L F  F  E + +C+YD+V+V + 
Sbjct: 595 LTKLNGSITSPGWPKEYPPNKNCIWQLVAPTQYRISLQFDFFETEGNDVCKYDFVEVRSG 654

Query: 83  ---EDQVLATFCGRETTDTEQTPGQEVVLSPGSFMSITFRSDFSNEERFTGFDAHYMAVD 139
              + ++   FCG E          EV+ S  + M + F+SD +  ++  GF AH+ + D
Sbjct: 655 LTADSKLHGKFCGSEKP--------EVITSQYNNMRVEFKSDNTVSKK--GFKAHFFS-D 703

Query: 140 VDECKEREDEELSCDHYCHNYIGGYYCSCRFGYILHTDNRTCRVECSDNLFTQRTGVITS 199
            DEC +   +   C   C N  G Y C CR G++LH +   C+    D+  T  +G ITS
Sbjct: 704 KDECSK---DNGGCQQDCVNTFGSYECQCRSGFVLHDNKHDCKEAGCDHKVTSTSGTITS 760

Query: 200 PDFPNPYPKSSECLYTIELEEGFMVNLQFEDIFDIEDHPEVPCPYDYIKIKVG----PKV 255
           P++P+ YP   EC + I    G  V L F ++ DIE  PE  C YD++++  G      V
Sbjct: 761 PNWPDKYPSKKECTWAISSTPGHRVKLTFMEM-DIESQPE--CAYDHLEVFDGRDAKAPV 817

Query: 256 LGPFCGEKAPEPISTQSHSVLILFHSDNSGENRGWRLSY 294
           LG FCG K PEP+      + + F+SDNS + +G++ S+
Sbjct: 818 LGRFCGSKKPEPVLATGSRMFLRFYSDNSVQRKGFQASH 856



 Score =  151 bits (381), Expect = 2e-36
 Identities = 90/282 (31%), Positives = 139/282 (49%), Gaps = 25/282 (8%)

Query: 28  FGQIQSPGYPDSYPSDSEVTWNITVPDGFRIKLYFMHFNLESSYLCEYDYVKV----ETE 83
           +G IQSP YPD Y       W I V +GF + L F  F +E    C YDY++V       
Sbjct: 443 YGHIQSPNYPDDYRPSKVCIWRIQVSEGFHVGLTFQSFEIERHDSCAYDYLEVRDGHSES 502

Query: 84  DQVLATFCGRETTDTEQTPGQEVVLSPGSFMSITFRSDFSNEERFTGFDAHYMAVDVDEC 143
             ++  +CG E  D         + S  S + + F SD S  +   GF  ++   +VDEC
Sbjct: 503 STLIGRYCGYEKPDD--------IKSTSSRLWLKFVSDGSINK--AGFAVNFFK-EVDEC 551

Query: 144 KEREDEELSCDHYCHNYIGGYYCSCRFGYILHTDNRTCRVECSDNLFTQRTGVITSPDFP 203
                    C+  C N +G Y CSC  GY L  D R C   C     T+  G ITSP +P
Sbjct: 552 S--RPNRGGCEQRCLNTLGSYKCSCDPGYELAPDKRRCEAACG-GFLTKLNGSITSPGWP 608

Query: 204 NPYPKSSECLYTIELEEGFMVNLQFEDIFDIEDHPEVPCPYDYIKIKVG----PKVLGPF 259
             YP +  C++ +     + ++LQF D F+ E +    C YD+++++ G     K+ G F
Sbjct: 609 KEYPPNKNCIWQLVAPTQYRISLQF-DFFETEGND--VCKYDFVEVRSGLTADSKLHGKF 665

Query: 260 CGEKAPEPISTQSHSVLILFHSDNSGENRGWRLSYRAAGNEC 301
           CG + PE I++Q +++ + F SDN+   +G++  + +  +EC
Sbjct: 666 CGSEKPEVITSQYNNMRVEFKSDNTVSKKGFKAHFFSDKDEC 707



 Score =  107 bits (268), Expect = 3e-23
 Identities = 85/276 (30%), Positives = 123/276 (44%), Gaps = 68/276 (24%)

Query: 29  GQIQSPGYPDSYPSDSEVTWNITVPDGFRIKLYFMHFNLESSYLCEYDYVKV----ETED 84
           G I SP +PD YPS  E TW I+   G R+KL FM  ++ES   C YD+++V    + + 
Sbjct: 756 GTITSPNWPDKYPSKKECTWAISSTPGHRVKLTFMEMDIESQPECAYDHLEVFDGRDAKA 815

Query: 85  QVLATFCGRETTDTEQTPGQEVVLSPGSFMSITFRSDFSNEERFTGFDAHYMAVDVDECK 144
            VL  FCG +          E VL+ GS M + F SD S + +  GF A +      EC 
Sbjct: 816 PVLGRFCGSKKP--------EPVLATGSRMFLRFYSDNSVQRK--GFQASHAT----ECG 861

Query: 145 EREDEELSC-DHYCHNYIGGYYCSCRFGYILHTDNRTCRVECSDNLFTQRTGVITSPDFP 203
            +   ++   D Y H   G                                         
Sbjct: 862 GQVRADVKTKDLYSHAQFGD---------------------------------------- 881

Query: 204 NPYPKSSECLYTIELEEGFMVNLQFEDIFDIEDHPEVPCPYDYIKIKVG-----PKVLGP 258
           N YP   +C + I  EEG+ V L F+  F++E+  E  C YDY+++  G     P+ LG 
Sbjct: 882 NNYPGGVDCEWVIVAEEGYGVELVFQT-FEVEE--ETDCGYDYMELFDGYDSTAPR-LGR 937

Query: 259 FCGEKAPEPISTQSHSVLILFHSDNSGENRGWRLSY 294
           +CG   PE + +   SVL+ FHSD++   +G+ L Y
Sbjct: 938 YCGSGPPEEVYSAGDSVLVKFHSDDTITKKGFHLRY 973



 Score = 95.9 bits (237), Expect = 1e-19
 Identities = 90/333 (27%), Positives = 137/333 (41%), Gaps = 73/333 (21%)

Query: 14  LSKASAHTVELNNMFGQIQSPGYPDSYPSDSEVTWNITVPDGFRIKLYFMHFNLESSYLC 73
           L K  A    L +  G   SP YP+ Y +     W I+V  G +I L F   +L  S LC
Sbjct: 316 LYKCPACGETLQDSTGNFSSPEYPNGYSAHMHCVWRISVTPGEKIILNFTSLDLYRSRLC 375

Query: 74  EYDYVKVE----TEDQVLATFCGRETTDTEQTPGQEVVLSPGSFMSITFRSDFSNEERFT 129
            YDYV+V      +  +   FCG +          E ++S  S + + FRS  S+     
Sbjct: 376 WYDYVEVRDGFWRKAPLRGRFCGSKL--------PEPIVSTDSRLWVEFRS--SSNWVGK 425

Query: 130 GFDAHYMAVDVDECKEREDEELSCDHYCHNYIGGYYCSCRFGYILHTDNRTCRVECSDNL 189
           GF A Y A+   + K+        D+                                  
Sbjct: 426 GFFAVYEAICGGDVKK--------DY---------------------------------- 443

Query: 190 FTQRTGVITSPDFPNPYPKSSECLYTIELEEGFMVNLQFEDIFDIEDHPEVPCPYDYIKI 249
                G I SP++P+ Y  S  C++ I++ EGF V L F+  F+IE H    C YDY+++
Sbjct: 444 -----GHIQSPNYPDDYRPSKVCIWRIQVSEGFHVGLTFQS-FEIERHDS--CAYDYLEV 495

Query: 250 KVG----PKVLGPFCGEKAPEPISTQSHSVLILFHSDNSGENRGWRLSYRAAGNECPELQ 305
           + G      ++G +CG + P+ I + S  + + F SD S    G+ +++    +EC    
Sbjct: 496 RDGHSESSTLIGRYCGYEKPDDIKSTSSRLWLKFVSDGSINKAGFAVNFFKEVDECSR-- 553

Query: 306 PPVHGKIEPSQAKYFFKDQVLVSCDTGYKVLKD 338
            P  G  E  Q           SCD GY++  D
Sbjct: 554 -PNRGGCE--QRCLNTLGSYKCSCDPGYELAPD 583


>gi|6912724 tolloid-like 2 [Homo sapiens]
          Length = 1015

 Score =  170 bits (431), Expect = 4e-42
 Identities = 100/287 (34%), Positives = 152/287 (52%), Gaps = 25/287 (8%)

Query: 23  ELNNMFGQIQSPGYPDSYPSDSEVTWNITVPDGFRIKLYFMHFNLESSYLCEYDYVKVE- 81
           ++N   GQIQSP YPD Y    E  W ITV +GF + L F  F +E    C YDY++V  
Sbjct: 467 DMNKDAGQIQSPNYPDDYRPSKECVWRITVSEGFHVGLTFQAFEIERHDSCAYDYLEVRD 526

Query: 82  ---TEDQVLATFCGRETTDTEQTPGQEVVLSPGSFMSITFRSDFSNEERFTGFDAHYMAV 138
               E  ++  FCG E          E V S  + + + F SD S  +   GF A++   
Sbjct: 527 GPTEESALIGHFCGYEK--------PEDVKSSSNRLWMKFVSDGSINK--AGFAANFFK- 575

Query: 139 DVDECKEREDEELSCDHYCHNYIGGYYCSCRFGYILHTDNRTCRVECSDNLFTQRTGVIT 198
           +VDEC     +   C+H C N +G Y C+C  GY L  D + C V C     T+  G IT
Sbjct: 576 EVDECS--WPDHGGCEHRCVNTLGSYKCACDPGYELAADKKMCEVACG-GFITKLNGTIT 632

Query: 199 SPDFPNPYPKSSECLYTIELEEGFMVNLQFEDIFDIEDHPEVPCPYDYIKIKVG----PK 254
           SP +P  YP +  C++ +     + ++LQFE +F++E +    C YD+++++ G     K
Sbjct: 633 SPGWPKEYPTNKNCVWQVVAPAQYRISLQFE-VFELEGND--VCKYDFVEVRSGLSPDAK 689

Query: 255 VLGPFCGEKAPEPISTQSHSVLILFHSDNSGENRGWRLSYRAAGNEC 301
           + G FCG + PE I++QS+++ + F SDN+   RG+R  + +  +EC
Sbjct: 690 LHGRFCGSETPEVITSQSNNMRVEFKSDNTVSKRGFRAHFFSDKDEC 736



 Score =  168 bits (425), Expect = 2e-41
 Identities = 94/276 (34%), Positives = 144/276 (52%), Gaps = 25/276 (9%)

Query: 24  LNNMFGQIQSPGYPDSYPSDSEVTWNITVPDGFRIKLYFMHFNLESSYLCEYDYVKVET- 82
           +  + G I SPG+P  YP++    W +  P  +RI L F  F LE + +C+YD+V+V + 
Sbjct: 624 ITKLNGTITSPGWPKEYPTNKNCVWQVVAPAQYRISLQFEVFELEGNDVCKYDFVEVRSG 683

Query: 83  ---EDQVLATFCGRETTDTEQTPGQEVVLSPGSFMSITFRSDFSNEERFTGFDAHYMAVD 139
              + ++   FCG ET         EV+ S  + M + F+SD +  +R  GF AH+ + D
Sbjct: 684 LSPDAKLHGRFCGSETP--------EVITSQSNNMRVEFKSDNTVSKR--GFRAHFFS-D 732

Query: 140 VDECKEREDEELSCDHYCHNYIGGYYCSCRFGYILHTDNRTCRVECSDNLFTQRTGVITS 199
            DEC +   +   C H C N  G Y C CR GY LH +   C+     +  +   G + S
Sbjct: 733 KDECAK---DNGGCQHECVNTFGSYLCRCRNGYWLHENGHDCKEAGCAHKISSVEGTLAS 789

Query: 200 PDFPNPYPKSSECLYTIELEEGFMVNLQFEDIFDIEDHPEVPCPYDYIKIKVGP----KV 255
           P++P+ YP   EC + I    G  V L F + F+IE H E  C YD++++  GP     +
Sbjct: 790 PNWPDKYPSRRECTWNISSTAGHRVKLTFNE-FEIEQHQE--CAYDHLEMYDGPDSLAPI 846

Query: 256 LGPFCGEKAPEPISTQSHSVLILFHSDNSGENRGWR 291
           LG FCG K P+P      S+ + F+SD S + +G++
Sbjct: 847 LGRFCGSKKPDPTVASGSSMFLRFYSDASVQRKGFQ 882



 Score =  110 bits (276), Expect = 4e-24
 Identities = 96/333 (28%), Positives = 143/333 (42%), Gaps = 73/333 (21%)

Query: 14  LSKASAHTVELNNMFGQIQSPGYPDSYPSDSEVTWNITVPDGFRIKLYFMHFNLESSYLC 73
           L K  A    L +  G   +PG+P+ YPS S   W I+V  G +I L F   +L  S LC
Sbjct: 345 LYKCPACGETLQDTTGNFSAPGFPNGYPSYSHCVWRISVTPGEKIVLNFTSMDLFKSRLC 404

Query: 74  EYDYVKVE----TEDQVLATFCGRETTDTEQTPGQEVVLSPGSFMSITFRSDFSNEERFT 129
            YDYV+V      +  +L  FCG      ++ P  E ++S  S + + FRS  S+     
Sbjct: 405 WYDYVEVRDGYWRKAPLLGRFCG------DKIP--EPLVSTDSRLWVEFRS--SSNILGK 454

Query: 130 GFDAHYMAVDVDECKEREDEELSCDHYCHNYIGGYYCSCRFGYILHTDNRTCRVECSDNL 189
           GF A Y A                                          TC  + + + 
Sbjct: 455 GFFAAYEA------------------------------------------TCGGDMNKD- 471

Query: 190 FTQRTGVITSPDFPNPYPKSSECLYTIELEEGFMVNLQFEDIFDIEDHPEVPCPYDYIKI 249
                G I SP++P+ Y  S EC++ I + EGF V L F+  F+IE H    C YDY+++
Sbjct: 472 ----AGQIQSPNYPDDYRPSKECVWRITVSEGFHVGLTFQ-AFEIERHDS--CAYDYLEV 524

Query: 250 KVGP----KVLGPFCGEKAPEPISTQSHSVLILFHSDNSGENRGWRLSYRAAGNECPELQ 305
           + GP     ++G FCG + PE + + S+ + + F SD S    G+  ++    +EC    
Sbjct: 525 RDGPTEESALIGHFCGYEKPEDVKSSSNRLWMKFVSDGSINKAGFAANFFKEVDEC---S 581

Query: 306 PPVHGKIEPSQAKYFFKDQVLVSCDTGYKVLKD 338
            P HG  E              +CD GY++  D
Sbjct: 582 WPDHGGCEHRCVNTL--GSYKCACDPGYELAAD 612



 Score = 95.1 bits (235), Expect = 2e-19
 Identities = 76/281 (27%), Positives = 120/281 (42%), Gaps = 66/281 (23%)

Query: 23   ELNNMFGQIQSPGYPDSYPSDSEVTWNITVPDGFRIKLYFMHFNLESSYLCEYDYVKV-- 80
            +++++ G + SP +PD YPS  E TWNI+   G R+KL F  F +E    C YD++++  
Sbjct: 779  KISSVEGTLASPNWPDKYPSRRECTWNISSTAGHRVKLTFNEFEIEQHQECAYDHLEMYD 838

Query: 81   --ETEDQVLATFCGRETTDTEQTPGQEVVLSPGSFMSITFRSDFSNEERFTGFDAHYMAV 138
              ++   +L  FCG +  D          ++ GS M + F SD S + +       + AV
Sbjct: 839  GPDSLAPILGRFCGSKKPDP--------TVASGSSMFLRFYSDASVQRK------GFQAV 884

Query: 139  DVDECKEREDEELSCDHYCHNYIGGYYCSCRFGYILHTDNRTCRVECSDNLFTQRTGVIT 198
               EC  R   E+             Y   +FG                           
Sbjct: 885  HSTECGGRLKAEVQTKE--------LYSHAQFG--------------------------- 909

Query: 199  SPDFPNPYPKSSECLYTIELEEGFMVNLQFEDIFDIEDHPEVPCPYDYIKIKVG-----P 253
                 N YP  + C + I  E+G+ V L F   F++E+  E  C YDY++   G     P
Sbjct: 910  ----DNNYPSEARCDWVIVAEDGYGVELTFR-TFEVEE--EADCGYDYMEAYDGYDSSAP 962

Query: 254  KVLGPFCGEKAPEPISTQSHSVLILFHSDNSGENRGWRLSY 294
            + LG FCG    E I +   S++I F +D++   +G+   Y
Sbjct: 963  R-LGRFCGSGPLEEIYSAGDSLMIRFRTDDTINKKGFHARY 1002



 Score = 48.9 bits (115), Expect = 2e-05
 Identities = 38/131 (29%), Positives = 58/131 (44%), Gaps = 23/131 (17%)

Query: 11   CFSLSKASAHTVELNN--MFGQIQSPGYPDSYPSDSEVTWNITVPDGFRIKLYFMHFNLE 68
            C    KA   T EL +   FG        ++YPS++   W I   DG+ ++L F  F +E
Sbjct: 889  CGGRLKAEVQTKELYSHAQFGD-------NNYPSEARCDWVIVAEDGYGVELTFRTFEVE 941

Query: 69   SSYLCEYDYVKV----ETEDQVLATFCGRETTDTEQTPGQEVVLSPGSFMSITFRSDFSN 124
                C YDY++     ++    L  FCG        +   E + S G  + I FR+D + 
Sbjct: 942  EEADCGYDYMEAYDGYDSSAPRLGRFCG--------SGPLEEIYSAGDSLMIRFRTDDTI 993

Query: 125  EERFTGFDAHY 135
             ++  GF A Y
Sbjct: 994  NKK--GFHARY 1002


>gi|22547221 tolloid-like 1 [Homo sapiens]
          Length = 1013

 Score =  167 bits (424), Expect = 2e-41
 Identities = 92/280 (32%), Positives = 149/280 (53%), Gaps = 27/280 (9%)

Query: 24  LNNMFGQIQSPGYPDSYPSDSEVTWNITVPDGFRIKLYFMHFNLESSYLCEYDYVKV--- 80
           L  + G I +PG+P  YP +    W +  P  +RI + F  F LE + +C+YDYV++   
Sbjct: 622 LTKLNGTITTPGWPKEYPPNKNCVWQVVAPTQYRISVKFEFFELEGNEVCKYDYVEIWSG 681

Query: 81  -ETEDQVLATFCGRETTDTEQTPGQEVVLSPGSFMSITFRSDFSNEERFTGFDAHYMAVD 139
             +E ++   FCG E          EV+ S  + M I F+SD +  ++  GF AH+ + D
Sbjct: 682 LSSESKLHGKFCGAEVP--------EVITSQFNNMRIEFKSDNTVSKK--GFKAHFFS-D 730

Query: 140 VDECKEREDEELSCDHYCHNYIGGYYCSCRFGYILHTDNRTCR-VECSDNLFTQRTGVIT 198
            DEC +   +   C H C N +G Y C CR G++LH +   C+  EC   + +  +G+IT
Sbjct: 731 KDECSK---DNGGCQHECVNTMGSYMCQCRNGFVLHDNKHDCKEAECEQKIHSP-SGLIT 786

Query: 199 SPDFPNPYPKSSECLYTIELEEGFMVNLQFEDIFDIEDHPEVPCPYDYIKIKVG----PK 254
           SP++P+ YP   EC + I    G  + L F + F+IE H E  C YD++++  G      
Sbjct: 787 SPNWPDKYPSRKECTWEISATPGHRIKLAFSE-FEIEQHQE--CAYDHLEVFDGETEKSP 843

Query: 255 VLGPFCGEKAPEPISTQSHSVLILFHSDNSGENRGWRLSY 294
           +LG  CG K P+P+    + + + F SD S + +G++ ++
Sbjct: 844 ILGRLCGNKIPDPLVATGNKMFVRFVSDASVQRKGFQATH 883



 Score =  153 bits (386), Expect = 6e-37
 Identities = 106/359 (29%), Positives = 172/359 (47%), Gaps = 43/359 (11%)

Query: 23  ELNNMFGQIQSPGYPDSYPSDSEVTWNITVPDGFRIKLYFMHFNLESSYLCEYDYVKV-- 80
           E+    GQIQSP YPD Y    E  W ITV + + + L F  F +E    C YDY++V  
Sbjct: 465 EIRKNEGQIQSPNYPDDYRPMKECVWKITVSESYHVGLTFQSFEIERHDNCAYDYLEVRD 524

Query: 81  --ETEDQVLATFCGRETTDTEQTPGQEVVLSPGSFMSITFRSDFSNEERFTGFDAHYMAV 138
                  ++  FCG +          E + S  + + + F SD +  +   GF A++   
Sbjct: 525 GTSENSPLIGRFCGYDK--------PEDIRSTSNTLWMKFVSDGTVNK--AGFAANFFK- 573

Query: 139 DVDECKEREDEELSCDHYCHNYIGGYYCSCRFGYILHTDNRTCRVECSDNLFTQRTGVIT 198
           + DEC   + +   C+  C N +G Y C+C  GY L  D R+C   C   L T+  G IT
Sbjct: 574 EEDEC--AKPDRGGCEQRCLNTLGSYQCACEPGYELGPDRRSCEAACG-GLLTKLNGTIT 630

Query: 199 SPDFPNPYPKSSECLYTIELEEGFMVNLQFEDIFDIEDHPEVPCPYDYIKIKVG----PK 254
           +P +P  YP +  C++ +     + ++++FE  F++E + EV C YDY++I  G     K
Sbjct: 631 TPGWPKEYPPNKNCVWQVVAPTQYRISVKFE-FFELEGN-EV-CKYDYVEIWSGLSSESK 687

Query: 255 VLGPFCGEKAPEPISTQSHSVLILFHSDNSGENRGWRLSYRAAGNECPELQPPVHGKIEP 314
           + G FCG + PE I++Q +++ I F SDN+   +G++  + +  +EC +       +   
Sbjct: 688 LHGKFCGAEVPEVITSQFNNMRIEFKSDNTVSKKGFKAHFFSDKDECSKDNGGCQHECVN 747

Query: 315 SQAKYFFKDQVLVSCDTGYKVLKDNVEMDTFQIEC----------LKDGTWSNKIPTCK 363
           +   Y      +  C  G+ VL DN + D  + EC          +    W +K P+ K
Sbjct: 748 TMGSY------MCQCRNGF-VLHDN-KHDCKEAECEQKIHSPSGLITSPNWPDKYPSRK 798



 Score =  104 bits (260), Expect = 3e-22
 Identities = 91/330 (27%), Positives = 143/330 (43%), Gaps = 75/330 (22%)

Query: 17  ASAHTVELNNMFGQIQSPGYPDSYPSDSEVTWNITVPDGFRIKLYFMHFNLESSYLCEYD 76
           A   T++ +N  G + SPG+P+ YPS +   W ++V  G +I L F   +L  S LC YD
Sbjct: 348 ACGETLQESN--GNLSSPGFPNGYPSYTHCIWRVSVTPGEKIVLNFTTMDLYKSSLCWYD 405

Query: 77  YVKVE----TEDQVLATFCGRETTDTEQTPGQEVVLSPGSFMSITFRSDFSNEERFTGFD 132
           Y++V      +  +L  FCG      ++ P  EV+ S  S M I FRS  S+     GF 
Sbjct: 406 YIEVRDGYWRKSPLLGRFCG------DKLP--EVLTSTDSRMWIEFRS--SSNWVGKGFA 455

Query: 133 AHYMAVDVDECKEREDEELSCDHYCHNYIGGYYCSCRFGYILHTDNRTCRVECSDNLFTQ 192
           A Y A+   E ++ E                                             
Sbjct: 456 AVYEAICGGEIRKNE--------------------------------------------- 470

Query: 193 RTGVITSPDFPNPYPKSSECLYTIELEEGFMVNLQFEDIFDIEDHPEVPCPYDYIKIKVG 252
             G I SP++P+ Y    EC++ I + E + V L F+  F+IE H    C YDY++++ G
Sbjct: 471 --GQIQSPNYPDDYRPMKECVWKITVSESYHVGLTFQS-FEIERHDN--CAYDYLEVRDG 525

Query: 253 PK----VLGPFCGEKAPEPISTQSHSVLILFHSDNSGENRGWRLSYRAAGNECPELQPPV 308
                 ++G FCG   PE I + S+++ + F SD +    G+  ++    +EC +   P 
Sbjct: 526 TSENSPLIGRFCGYDKPEDIRSTSNTLWMKFVSDGTVNKAGFAANFFKEEDECAK---PD 582

Query: 309 HGKIEPSQAKYFFKDQVLVSCDTGYKVLKD 338
            G  E          Q   +C+ GY++  D
Sbjct: 583 RGGCEQRCLNTLGSYQ--CACEPGYELGPD 610



 Score =  101 bits (251), Expect = 3e-21
 Identities = 82/283 (28%), Positives = 123/283 (43%), Gaps = 66/283 (23%)

Query: 23   ELNNMFGQIQSPGYPDSYPSDSEVTWNITVPDGFRIKLYFMHFNLESSYLCEYDYVKV-- 80
            ++++  G I SP +PD YPS  E TW I+   G RIKL F  F +E    C YD+++V  
Sbjct: 777  KIHSPSGLITSPNWPDKYPSRKECTWEISATPGHRIKLAFSEFEIEQHQECAYDHLEVFD 836

Query: 81   -ETE-DQVLATFCGRETTDTEQTPGQEVVLSPGSFMSITFRSDFSNEERFTGFDAHYMAV 138
             ETE   +L   CG +  D         +++ G+ M + F SD S + +  GF A +   
Sbjct: 837  GETEKSPILGRLCGNKIPDP--------LVATGNKMFVRFVSDASVQRK--GFQATHST- 885

Query: 139  DVDECKER-EDEELSCDHYCHNYIGGYYCSCRFGYILHTDNRTCRVECSDNLFTQRTGVI 197
               EC  R + E    D Y H   G                                   
Sbjct: 886  ---ECGGRLKAESKPRDLYSHAQFG----------------------------------- 907

Query: 198  TSPDFPNPYPKSSECLYTIELEEGFMVNLQFEDIFDIEDHPEVPCPYDYIKIKVG----P 253
                  N YP   +C + +  E G  + L F+  F++E+  E  C YDY+++  G     
Sbjct: 908  -----DNNYPGQVDCEWLLVSERGSRLELSFQ-TFEVEE--EADCGYDYVELFDGLDSTA 959

Query: 254  KVLGPFCGEKAPEPISTQSHSVLILFHSDNSGENRGWRLSYRA 296
              LG FCG   PE I +   SVLI FH+D++   +G+ + Y++
Sbjct: 960  VGLGRFCGSGPPEEIYSIGDSVLIHFHTDDTINKKGFHIRYKS 1002


>gi|4503649 coagulation factor IX preproprotein [Homo sapiens]
          Length = 461

 Score =  159 bits (402), Expect = 9e-39
 Identities = 95/273 (34%), Positives = 148/273 (54%), Gaps = 42/273 (15%)

Query: 449 RIIGGRNAEPGLFPWQALIVVEDTSRVPNDKWFGSGALLSASWILTAAHVLRSQRRDTTV 508
           R++GG +A+PG FPWQ ++  +  +       F  G++++  WI+TAAH + +  +    
Sbjct: 226 RVVGGEDAKPGQFPWQVVLNGKVDA-------FCGGSIVNEKWIVTAAHCVETGVK---- 274

Query: 509 IPVSKEHVTVYLGLHDVRDKSGAVNS-SAARVVLHPDFN--IQNYNHDIALVQLQEPVPL 565
                  +TV  G H++ +        +  R++ H ++N  I  YNHDIAL++L EP+ L
Sbjct: 275 -------ITVVAGEHNIEETEHTEQKRNVIRIIPHHNYNAAINKYNHDIALLELDEPLVL 327

Query: 566 GPHVMPVCLPRLEPEGPAPHM-LGLVAGWGISNPNVTVDEIISSGTRTLSDVLQYVKLPV 624
             +V P+C+   E          G V+GWG          +   G   L  VLQY+++P+
Sbjct: 328 NSYVTPICIADKEYTNIFLKFGSGYVSGWG---------RVFHKGRSAL--VLQYLRVPL 376

Query: 625 VPHAECKTSYESRSGNYSVTENMFCAGYYEGGKDTCLGDSGGAFVIFDDLSQRWVVQGLV 684
           V  A C      RS  +++  NMFCAG++EGG+D+C GDSGG  V   ++     + G++
Sbjct: 377 VDRATCL-----RSTKFTIYNNMFCAGFHEGGRDSCQGDSGGPHV--TEVEGTSFLTGII 429

Query: 685 SWGGPEECGSKQVYGVYTKVSNYVDWVWEQMGL 717
           SWG  EEC  K  YG+YTKVS YV+W+ E+  L
Sbjct: 430 SWG--EECAMKGKYGIYTKVSRYVNWIKEKTKL 460



 Score = 32.0 bits (71), Expect = 2.1
 Identities = 22/71 (30%), Positives = 31/71 (43%), Gaps = 9/71 (12%)

Query: 119 RSDFSNEERFTGFDAHYMAVDVDECKEREDEELSCDHYCHNYIGGYYCSCRFGYILHTDN 178
           R  F N ER T F   Y  VD D+C   E         C + I  Y C C FG+    + 
Sbjct: 75  REVFENTERTTEFWKQY--VDGDQC---ESNPCLNGGSCKDDINSYECWCPFGF----EG 125

Query: 179 RTCRVECSDNL 189
           + C ++ + N+
Sbjct: 126 KNCELDVTCNI 136


>gi|4826762 haptoglobin isoform 1 preproprotein [Homo sapiens]
          Length = 406

 Score =  159 bits (402), Expect = 9e-39
 Identities = 125/431 (29%), Positives = 190/431 (44%), Gaps = 76/431 (17%)

Query: 297 AGNECPELQPPVHGKIEPS---QAKYFFKDQVLVSCDTGYKVLKDNVEMDTFQIECLKDG 353
           A + CP+     HG +E S   Q K ++K   L +   G   L D  +     +      
Sbjct: 29  ADDGCPKPPEIAHGYVEHSVRYQCKNYYK---LRTEGDGVYTLNDKKQWINKAV------ 79

Query: 354 TWSNKIPTCKIVD-CRAPGELEHGLITFSTRNNLTTYKSEIKYSCQEPYYKMLNNNTGIY 412
              +K+P C+  D C  P E+ HG +  S R           Y C+  YYK+     G+Y
Sbjct: 80  --GDKLPECEADDGCPKPPEIAHGYVEHSVR-----------YQCKN-YYKLRTEGDGVY 125

Query: 413 TCSAQGVWMNKVLGRSLPTCLPECGQPSRSLPSLVKRIIGGRNAEPGLFPWQALIVVEDT 472
           T + +  W+NK +G  LP C   CG+P ++  + V+RI+GG     G FPWQA +V    
Sbjct: 126 TLNNEKQWINKAVGDKLPECEAVCGKP-KNPANPVQRILGGHLDAKGSFPWQAKMVSHHN 184

Query: 473 SRVPNDKWFGSGALLSASWILTAAHVLRSQRRDTTVIPVSKEHVTVYLGLHDVRDKSGAV 532
                        L++  W+LT A  L     +          +T+Y+G   + +     
Sbjct: 185 LTT-------GATLINEQWLLTTAKNLFLNHSENATAKDIAPTLTLYVGKKQLVE----- 232

Query: 533 NSSAARVVLHPDFNIQNYNHDIALVQLQEPVPLGPHVMPVCLPRLEPEGPAPHMLGLVAG 592
                +VVLHP+++      DI L++L++ V +   VMP+CLP    +      +G V+G
Sbjct: 233 ---IEKVVLHPNYS----QVDIGLIKLKQKVSVNERVMPICLP--SKDYAEVGRVGYVSG 283

Query: 593 WGISNPNVTVDEIISSGTRTLSDVLQYVKLPVVPHAECKTSYESRSGNYSVT-------- 644
           WG  N N              +D L+YV LPV    +C   YE  +     T        
Sbjct: 284 WG-RNANFK-----------FTDHLKYVMLPVADQDQCIRHYEGSTVPEKKTPKSPVGVQ 331

Query: 645 ----ENMFCAGYYEGGKDTCLGDSGGAFVIFDDLSQRWVVQGLVSWGGPEECGSKQVYGV 700
               E+ FCAG  +  +DTC GD+G AF + D     W   G++S+   + C   + YGV
Sbjct: 332 PILNEHTFCAGMSKYQEDTCYGDAGSAFAVHDLEEDTWYATGILSF--DKSCAVAE-YGV 388

Query: 701 YTKVSNYVDWV 711
           Y KV++  DWV
Sbjct: 389 YVKVTSIQDWV 399


>gi|11415040 matriptase [Homo sapiens]
          Length = 855

 Score =  154 bits (389), Expect = 3e-37
 Identities = 178/726 (24%), Positives = 283/726 (38%), Gaps = 141/726 (19%)

Query: 33  SPGYPDS-YPSDSEVTWNITVPDGFRIKLYFMHFNLESSYLCEYDYVKVET-----EDQV 86
           +PG+PDS YP+ +   W +       + L F  F+L S      D V V       E   
Sbjct: 230 TPGFPDSPYPAHARCQWALRGDADSVLSLTFRSFDLASCDERGSDLVTVYNTLSPMEPHA 289

Query: 87  LATFCGRETTDTEQT--PGQEVVLSPGSFMSITFRSDFSNEERFTGFDAHYMAVDVDECK 144
           L   CG        T    Q V+L       IT  ++   E R  GF+A +  +      
Sbjct: 290 LVQLCGTYPPSYNLTFHSSQNVLL-------ITLITN--TERRHPGFEATFFQLP----- 335

Query: 145 EREDEELSCDHYCHNYIGGYYCSCRFGYILHTDNRTCRVECSDNLFTQRTGVITSPDFPN 204
                                                R+        +  G   SP +P 
Sbjct: 336 -------------------------------------RMSSCGGRLRKAQGTFNSPYYPG 358

Query: 205 PYPKSSECLYTIELEEGFMVNLQFEDIFDIEDHPEVP---CPYDYIKIKVGPKVLGPFCG 261
            YP + +C + IE+     V ++F+  + +E  P VP   CP DY++I  G K    +CG
Sbjct: 359 HYPPNIDCTWNIEVPNNQHVKVRFKFFYLLE--PGVPAGTCPKDYVEIN-GEK----YCG 411

Query: 262 EKAPEPISTQSHSVLILFHSDNSGENRGWRLSYRA--AGNECPELQPPVHGKIEPSQAKY 319
           E++   +++ S+ + + FHSD S  + G+   Y +  + + CP       G+    + + 
Sbjct: 412 ERSQFVVTSNSNKITVRFHSDQSYTDTGFLAEYLSYDSSDPCPGQFTCRTGRCIRKELRC 471

Query: 320 F-------FKDQVLVSCDTGYKVLKDNVEMDTFQIECLKDGTWSNKIPTCKIVDCRAPGE 372
                     D++  SCD G++    N        +  K   W      C  V+      
Sbjct: 472 DGWADCTDHSDELNCSCDAGHQFTCKN--------KFCKPLFW-----VCDSVNDCGDNS 518

Query: 373 LEHGLI----TFSTRNNLTTYKSEI---KYSCQEPYYKMLNNNTGIYTCSAQGV-WMNKV 424
            E G      TF   N     KS+    K  C +   +       + TC+      +N +
Sbjct: 519 DEQGCSCPAQTFRCSNGKCLSKSQQCNGKDDCGDGSDEASCPKVNVVTCTKHTYRCLNGL 578

Query: 425 -LGRSLPTC--LPECGQPSRS------LPSLVK--RIIGGRNAEPGLFPWQALIVVEDTS 473
            L +  P C    +C   S        L S  +  R++GG +A+ G +PWQ  +      
Sbjct: 579 CLSKGNPECDGKEDCSDGSDEKDCDCGLRSFTRQARVVGGTDADEGEWPWQVSLHALGQG 638

Query: 474 RVPNDKWFGSGALLSASWILTAAHVLRSQRRDTTVIPVSKEHVTVYLGLHDVRDKS--GA 531
            +         +L+S +W+++AAH     R      P      T +LGLHD   +S  G 
Sbjct: 639 HICG------ASLISPNWLVSAAHCYIDDRGFRYSDPTQW---TAFLGLHDQSQRSAPGV 689

Query: 532 VNSSAARVVLHPDFNIQNYNHDIALVQLQEPVPLGPHVMPVCLPRLEPEGPAPHMLGLVA 591
                 R++ HP FN   +++DIAL++L++P      V P+CLP      PA   +  V 
Sbjct: 690 QERRLKRIISHPFFNDFTFDYDIALLELEKPAEYSSMVRPICLPDASHVFPAGKAI-WVT 748

Query: 592 GWGISNPNVTVDEIISSGTRTLSDVLQYVKLPVVPHAECKTSYESRSGNYSVTENMFCAG 651
           GWG +            GT  L  +LQ  ++ V+    C+     +     +T  M C G
Sbjct: 749 GWGHTQ---------YGGTGAL--ILQKGEIRVINQTTCENLLPQQ-----ITPRMMCVG 792

Query: 652 YYEGGKDTCLGDSGGAFVIFDDLSQRWVVQGLVSWGGPEECGSKQVYGVYTKVSNYVDWV 711
           +  GG D+C GDSGG      +   R    G+VSWG  + C  +   GVYT++  + DW+
Sbjct: 793 FLSGGVDSCQGDSGGPLSSV-EADGRIFQAGVVSWG--DGCAQRNKPGVYTRLPLFRDWI 849

Query: 712 WEQMGL 717
            E  G+
Sbjct: 850 KENTGV 855



 Score = 68.2 bits (165), Expect = 3e-11
 Identities = 58/206 (28%), Positives = 88/206 (42%), Gaps = 39/206 (18%)

Query: 7   YYALCFSLSKASAHTVELNNMFGQIQSPGYPDSYPSDSEVTWNITVPDGFRIKLYFMHFN 66
           + A  F L + S+    L    G   SP YP  YP + + TWNI VP+   +K+ F  F 
Sbjct: 327 FEATFFQLPRMSSCGGRLRKAQGTFNSPYYPGHYPPNIDCTWNIEVPNNQHVKVRFKFFY 386

Query: 67  L----ESSYLCEYDYVKVETEDQVLATFCGRETTDTEQTPGQEVVLSPGSFMSITFRSDF 122
           L      +  C  DYV++  E      +CG  +        Q VV S  + +++ F SD 
Sbjct: 387 LLEPGVPAGTCPKDYVEINGE-----KYCGERS--------QFVVTSNSNKITVRFHSDQ 433

Query: 123 SNEERFTGFDAHYMAVDVDE-------CKERE--DEELSCDHY--CHNYIGGYYCSCRFG 171
           S  +  TGF A Y++ D  +       C+      +EL CD +  C ++     CSC  G
Sbjct: 434 SYTD--TGFLAEYLSYDSSDPCPGQFTCRTGRCIRKELRCDGWADCTDHSDELNCSCDAG 491

Query: 172 YILHTDNRTCRV---------ECSDN 188
           +     N+ C+          +C DN
Sbjct: 492 HQFTCKNKFCKPLFWVCDSVNDCGDN 517


>gi|4502421 bone morphogenetic protein 1 isoform 1 precursor [Homo
           sapiens]
          Length = 730

 Score =  153 bits (386), Expect = 6e-37
 Identities = 96/300 (32%), Positives = 146/300 (48%), Gaps = 30/300 (10%)

Query: 28  FGQIQSPGYPDSYPSDSEVTWNITVPDGFRIKLYFMHFNLESSYLCEYDYVKV----ETE 83
           +G IQSP YPD Y       W I V +GF + L F  F +E    C YDY++V       
Sbjct: 443 YGHIQSPNYPDDYRPSKVCIWRIQVSEGFHVGLTFQSFEIERHDSCAYDYLEVRDGHSES 502

Query: 84  DQVLATFCGRETTDTEQTPGQEVVLSPGSFMSITFRSDFSNEERFTGFDAHYMAVDVDEC 143
             ++  +CG E  D         + S  S + + F SD S  +   GF  ++   +VDEC
Sbjct: 503 STLIGRYCGYEKPDD--------IKSTSSRLWLKFVSDGSINK--AGFAVNFFK-EVDEC 551

Query: 144 KEREDEELSCDHYCHNYIGGYYCSCRFGYILHTDNRTCRVECSDNLFTQRTGVITSPDFP 203
                    C+  C N +G Y CSC  GY L  D R C   C     T+  G ITSP +P
Sbjct: 552 S--RPNRGGCEQRCLNTLGSYKCSCDPGYELAPDKRRCEAACG-GFLTKLNGSITSPGWP 608

Query: 204 NPYPKSSECLYTIELEEGFMVNLQFEDIFDIEDHPEVPCPYDYIKIKVG----PKVLGPF 259
             YP +  C++ +     + ++LQF D F+ E +    C YD+++++ G     K+ G F
Sbjct: 609 KEYPPNKNCIWQLVAPTQYRISLQF-DFFETEGND--VCKYDFVEVRSGLTADSKLHGKF 665

Query: 260 CGEKAPEPISTQSHSVLILFHSDNSGENRGWRLSYRAAGNECPELQPPVHGKIEPSQAKY 319
           CG + PE I++Q +++ + F SDN+   +G++  +     + P LQPP   +  P Q K+
Sbjct: 666 CGSEKPEVITSQYNNMRVEFKSDNTVSKKGFKAHF--FSEKRPALQPP---RGRPHQLKF 720



 Score = 95.9 bits (237), Expect = 1e-19
 Identities = 90/333 (27%), Positives = 137/333 (41%), Gaps = 73/333 (21%)

Query: 14  LSKASAHTVELNNMFGQIQSPGYPDSYPSDSEVTWNITVPDGFRIKLYFMHFNLESSYLC 73
           L K  A    L +  G   SP YP+ Y +     W I+V  G +I L F   +L  S LC
Sbjct: 316 LYKCPACGETLQDSTGNFSSPEYPNGYSAHMHCVWRISVTPGEKIILNFTSLDLYRSRLC 375

Query: 74  EYDYVKVE----TEDQVLATFCGRETTDTEQTPGQEVVLSPGSFMSITFRSDFSNEERFT 129
            YDYV+V      +  +   FCG +          E ++S  S + + FRS  S+     
Sbjct: 376 WYDYVEVRDGFWRKAPLRGRFCGSKL--------PEPIVSTDSRLWVEFRS--SSNWVGK 425

Query: 130 GFDAHYMAVDVDECKEREDEELSCDHYCHNYIGGYYCSCRFGYILHTDNRTCRVECSDNL 189
           GF A Y A+   + K+        D+                                  
Sbjct: 426 GFFAVYEAICGGDVKK--------DY---------------------------------- 443

Query: 190 FTQRTGVITSPDFPNPYPKSSECLYTIELEEGFMVNLQFEDIFDIEDHPEVPCPYDYIKI 249
                G I SP++P+ Y  S  C++ I++ EGF V L F+  F+IE H    C YDY+++
Sbjct: 444 -----GHIQSPNYPDDYRPSKVCIWRIQVSEGFHVGLTFQS-FEIERHDS--CAYDYLEV 495

Query: 250 KVG----PKVLGPFCGEKAPEPISTQSHSVLILFHSDNSGENRGWRLSYRAAGNECPELQ 305
           + G      ++G +CG + P+ I + S  + + F SD S    G+ +++    +EC    
Sbjct: 496 RDGHSESSTLIGRYCGYEKPDDIKSTSSRLWLKFVSDGSINKAGFAVNFFKEVDECSR-- 553

Query: 306 PPVHGKIEPSQAKYFFKDQVLVSCDTGYKVLKD 338
            P  G  E  Q           SCD GY++  D
Sbjct: 554 -PNRGGCE--QRCLNTLGSYKCSCDPGYELAPD 583



 Score = 67.0 bits (162), Expect = 6e-11
 Identities = 38/118 (32%), Positives = 58/118 (49%), Gaps = 14/118 (11%)

Query: 24  LNNMFGQIQSPGYPDSYPSDSEVTWNITVPDGFRIKLYFMHFNLESSYLCEYDYVKVET- 82
           L  + G I SPG+P  YP +    W +  P  +RI L F  F  E + +C+YD+V+V + 
Sbjct: 595 LTKLNGSITSPGWPKEYPPNKNCIWQLVAPTQYRISLQFDFFETEGNDVCKYDFVEVRSG 654

Query: 83  ---EDQVLATFCGRETTDTEQTPGQEVVLSPGSFMSITFRSDFSNEERFTGFDAHYMA 137
              + ++   FCG E          EV+ S  + M + F+SD  N     GF AH+ +
Sbjct: 655 LTADSKLHGKFCGSEK--------PEVITSQYNNMRVEFKSD--NTVSKKGFKAHFFS 702


>gi|186910296 haptoglobin isoform 2 preproprotein [Homo sapiens]
          Length = 347

 Score =  150 bits (379), Expect = 4e-36
 Identities = 107/357 (29%), Positives = 161/357 (45%), Gaps = 61/357 (17%)

Query: 367 CRAPGELEHGLITFSTRNNLTTYKSEIKYSCQEPYYKMLNNNTGIYTCSAQGVWMNKVLG 426
           C  P E+ HG +  S R           Y C+  YYK+     G+YT + +  W+NK +G
Sbjct: 33  CPKPPEIAHGYVEHSVR-----------YQCKN-YYKLRTEGDGVYTLNNEKQWINKAVG 80

Query: 427 RSLPTCLPECGQPSRSLPSLVKRIIGGRNAEPGLFPWQALIVVEDTSRVPNDKWFGSGAL 486
             LP C   CG+P ++  + V+RI+GG     G FPWQA +V                 L
Sbjct: 81  DKLPECEAVCGKP-KNPANPVQRILGGHLDAKGSFPWQAKMVSHHNLTT-------GATL 132

Query: 487 LSASWILTAAHVLRSQRRDTTVIPVSKEHVTVYLGLHDVRDKSGAVNSSAARVVLHPDFN 546
           ++  W+LT A  L     +          +T+Y+G   + +          +VVLHP+++
Sbjct: 133 INEQWLLTTAKNLFLNHSENATAKDIAPTLTLYVGKKQLVE--------IEKVVLHPNYS 184

Query: 547 IQNYNHDIALVQLQEPVPLGPHVMPVCLPRLEPEGPAPHMLGLVAGWGISNPNVTVDEII 606
                 DI L++L++ V +   VMP+CLP    +      +G V+GWG  N N       
Sbjct: 185 ----QVDIGLIKLKQKVSVNERVMPICLP--SKDYAEVGRVGYVSGWG-RNANFK----- 232

Query: 607 SSGTRTLSDVLQYVKLPVVPHAECKTSYESRSGNYSVT------------ENMFCAGYYE 654
                  +D L+YV LPV    +C   YE  +     T            E+ FCAG  +
Sbjct: 233 ------FTDHLKYVMLPVADQDQCIRHYEGSTVPEKKTPKSPVGVQPILNEHTFCAGMSK 286

Query: 655 GGKDTCLGDSGGAFVIFDDLSQRWVVQGLVSWGGPEECGSKQVYGVYTKVSNYVDWV 711
             +DTC GD+G AF + D     W   G++S+   + C   + YGVY KV++  DWV
Sbjct: 287 YQEDTCYGDAGSAFAVHDLEEDTWYATGILSF--DKSCAVAE-YGVYVKVTSIQDWV 340


>gi|5902808 bone morphogenetic protein 1 isoform 2 precursor [Homo
           sapiens]
          Length = 823

 Score =  147 bits (372), Expect = 3e-35
 Identities = 88/275 (32%), Positives = 135/275 (49%), Gaps = 25/275 (9%)

Query: 28  FGQIQSPGYPDSYPSDSEVTWNITVPDGFRIKLYFMHFNLESSYLCEYDYVKV----ETE 83
           +G IQSP YPD Y       W I V +GF + L F  F +E    C YDY++V       
Sbjct: 443 YGHIQSPNYPDDYRPSKVCIWRIQVSEGFHVGLTFQSFEIERHDSCAYDYLEVRDGHSES 502

Query: 84  DQVLATFCGRETTDTEQTPGQEVVLSPGSFMSITFRSDFSNEERFTGFDAHYMAVDVDEC 143
             ++  +CG E  D         + S  S + + F SD S  +   GF  ++   +VDEC
Sbjct: 503 STLIGRYCGYEKPDD--------IKSTSSRLWLKFVSDGSINK--AGFAVNFFK-EVDEC 551

Query: 144 KEREDEELSCDHYCHNYIGGYYCSCRFGYILHTDNRTCRVECSDNLFTQRTGVITSPDFP 203
                    C+  C N +G Y CSC  GY L  D R C   C     T+  G ITSP +P
Sbjct: 552 S--RPNRGGCEQRCLNTLGSYKCSCDPGYELAPDKRRCEAACG-GFLTKLNGSITSPGWP 608

Query: 204 NPYPKSSECLYTIELEEGFMVNLQFEDIFDIEDHPEVPCPYDYIKIKVG----PKVLGPF 259
             YP +  C++ +     + ++LQF D F+ E +    C YD+++++ G     K+ G F
Sbjct: 609 KEYPPNKNCIWQLVAPTQYRISLQF-DFFETEGND--VCKYDFVEVRSGLTADSKLHGKF 665

Query: 260 CGEKAPEPISTQSHSVLILFHSDNSGENRGWRLSY 294
           CG + PE I++Q +++ + F SDN+   +G++  +
Sbjct: 666 CGSEKPEVITSQYNNMRVEFKSDNTVSKKGFKAHF 700



 Score = 95.9 bits (237), Expect = 1e-19
 Identities = 90/333 (27%), Positives = 137/333 (41%), Gaps = 73/333 (21%)

Query: 14  LSKASAHTVELNNMFGQIQSPGYPDSYPSDSEVTWNITVPDGFRIKLYFMHFNLESSYLC 73
           L K  A    L +  G   SP YP+ Y +     W I+V  G +I L F   +L  S LC
Sbjct: 316 LYKCPACGETLQDSTGNFSSPEYPNGYSAHMHCVWRISVTPGEKIILNFTSLDLYRSRLC 375

Query: 74  EYDYVKVE----TEDQVLATFCGRETTDTEQTPGQEVVLSPGSFMSITFRSDFSNEERFT 129
            YDYV+V      +  +   FCG +          E ++S  S + + FRS  S+     
Sbjct: 376 WYDYVEVRDGFWRKAPLRGRFCGSKL--------PEPIVSTDSRLWVEFRS--SSNWVGK 425

Query: 130 GFDAHYMAVDVDECKEREDEELSCDHYCHNYIGGYYCSCRFGYILHTDNRTCRVECSDNL 189
           GF A Y A+   + K+        D+                                  
Sbjct: 426 GFFAVYEAICGGDVKK--------DY---------------------------------- 443

Query: 190 FTQRTGVITSPDFPNPYPKSSECLYTIELEEGFMVNLQFEDIFDIEDHPEVPCPYDYIKI 249
                G I SP++P+ Y  S  C++ I++ EGF V L F+  F+IE H    C YDY+++
Sbjct: 444 -----GHIQSPNYPDDYRPSKVCIWRIQVSEGFHVGLTFQS-FEIERHDS--CAYDYLEV 495

Query: 250 KVG----PKVLGPFCGEKAPEPISTQSHSVLILFHSDNSGENRGWRLSYRAAGNECPELQ 305
           + G      ++G +CG + P+ I + S  + + F SD S    G+ +++    +EC    
Sbjct: 496 RDGHSESSTLIGRYCGYEKPDDIKSTSSRLWLKFVSDGSINKAGFAVNFFKEVDECSR-- 553

Query: 306 PPVHGKIEPSQAKYFFKDQVLVSCDTGYKVLKD 338
            P  G  E  Q           SCD GY++  D
Sbjct: 554 -PNRGGCE--QRCLNTLGSYKCSCDPGYELAPD 583



 Score = 68.6 bits (166), Expect = 2e-11
 Identities = 39/119 (32%), Positives = 59/119 (49%), Gaps = 14/119 (11%)

Query: 24  LNNMFGQIQSPGYPDSYPSDSEVTWNITVPDGFRIKLYFMHFNLESSYLCEYDYVKVET- 82
           L  + G I SPG+P  YP +    W +  P  +RI L F  F  E + +C+YD+V+V + 
Sbjct: 595 LTKLNGSITSPGWPKEYPPNKNCIWQLVAPTQYRISLQFDFFETEGNDVCKYDFVEVRSG 654

Query: 83  ---EDQVLATFCGRETTDTEQTPGQEVVLSPGSFMSITFRSDFSNEERFTGFDAHYMAV 138
              + ++   FCG E          EV+ S  + M + F+SD  N     GF AH+ +V
Sbjct: 655 LTADSKLHGKFCGSEK--------PEVITSQYNNMRVEFKSD--NTVSKKGFKAHFFSV 703


>gi|78191798 plasma kallikrein B1 precursor [Homo sapiens]
          Length = 638

 Score =  145 bits (366), Expect = 1e-34
 Identities = 94/290 (32%), Positives = 144/290 (49%), Gaps = 35/290 (12%)

Query: 426 GRSLPTCLPECGQPSRSLPSLVKRIIGGRNAEPGLFPWQALIVVEDTSRVPNDKWFGSGA 485
           G SL  C    G  S        RI+GG N+  G +PWQ  + V+ T++    +    G+
Sbjct: 369 GYSLRLC--NTGDNSVCTTKTSTRIVGGTNSSWGEWPWQVSLQVKLTAQ----RHLCGGS 422

Query: 486 LLSASWILTAAHVLRSQRRDTTVIPVSKEHVTVYLGLHDVRD-KSGAVNSSAARVVLHPD 544
           L+   W+LTAAH           +P+ ++   +Y G+ ++ D       S    +++H +
Sbjct: 423 LIGHQWVLTAAHCFDG-------LPL-QDVWRIYSGILNLSDITKDTPFSQIKEIIIHQN 474

Query: 545 FNIQNYNHDIALVQLQEPVPLGPHVMPVCLPRLEPEGPAPHMLGLVAGWGISNPNVTVDE 604
           + +   NHDIAL++LQ P+       P+CLP  + +    +    V GWG S     +  
Sbjct: 475 YKVSEGNHDIALIKLQAPLNYTEFQKPICLPS-KGDTSTIYTNCWVTGWGFSKEKGEIQN 533

Query: 605 IISSGTRTLSDVLQYVKLPVVPHAECKTSYESRSGNYSVTENMFCAGYYEGGKDTCLGDS 664
           I           LQ V +P+V + EC+  Y+    +Y +T+ M CAGY EGGKD C GDS
Sbjct: 534 I-----------LQKVNIPLVTNEECQKRYQ----DYKITQRMVCAGYKEGGKDACKGDS 578

Query: 665 GGAFVIFDDLSQRWVVQGLVSWGGPEECGSKQVYGVYTKVSNYVDWVWEQ 714
           GG  V     +  W + G+ SWG  E C  ++  GVYTKV+ Y+DW+ E+
Sbjct: 579 GGPLVC--KHNGMWRLVGITSWG--EGCARREQPGVYTKVAEYMDWILEK 624


>gi|110578663 hypothetical protein LOC203074 [Homo sapiens]
          Length = 352

 Score =  141 bits (355), Expect = 2e-33
 Identities = 94/285 (32%), Positives = 137/285 (48%), Gaps = 39/285 (13%)

Query: 430 PTCLPECGQPSRSL---PSLVKRIIGGRNAEPGLFPWQALIVVEDTSRVPNDKWFGSGAL 486
           P+ + ECG   RS+    +   RI GG  AE G FPWQ  I             F  G++
Sbjct: 47  PSPVSECGD--RSIFEGRTRYSRITGGMEAEVGEFPWQVSIQARSEP-------FCGGSI 97

Query: 487 LSASWILTAAHVLRSQRRDTTVIPVSKEHVTVYLGLHDVRDKSGAVNSSAARVVLHPDFN 546
           L+  WILTAAH L S+        +  E ++V LG +D+   S  +   A+ ++LH DF 
Sbjct: 98  LNKWWILTAAHCLYSEE-------LFPEELSVVLGTNDLTSPSMEIKEVAS-IILHKDFK 149

Query: 547 IQNYNHDIALVQLQEPVPLGPHVMPVCLPRLEPEGPAPHMLGLVAGWGISNPNVTVDEII 606
             N ++DIAL+ L  P+ L    +P+CLP     GPA      VAGWG +N         
Sbjct: 150 RANMDNDIALLLLASPIKLDDLKVPICLPT--QPGPATWRECWVAGWGQTN--------- 198

Query: 607 SSGTRTLSDVLQYVKLPVVPHAECKTSYESRSGNYSVTENMFCAGYYEGGKDTCLGDSGG 666
           ++   ++   L    + ++   EC   +        +T+NM CAGY     D C GDSGG
Sbjct: 199 AADKNSVKTDLMKAPMVIMDWEECSKMFPK------LTKNMLCAGYKNESYDACKGDSGG 252

Query: 667 AFVIFDDLSQRWVVQGLVSWGGPEECGSKQVYGVYTKVSNYVDWV 711
             V   +  ++W   G++SWG  + CG K   G+YT + NY  W+
Sbjct: 253 PLVCTPEPGEKWYQVGIISWG--KSCGEKNTPGIYTSLVNYNLWI 295


>gi|45580723 haptoglobin-related protein [Homo sapiens]
          Length = 348

 Score =  140 bits (354), Expect = 3e-33
 Identities = 97/330 (29%), Positives = 151/330 (45%), Gaps = 50/330 (15%)

Query: 394 KYSCQEPYYKMLNNNTGIYTCSAQGVWMNKVLGRSLPTCLPECGQPSRSLPSLVKRIIGG 453
           +Y C+  YY++     G+YT + +  W+NK +G  LP C   CG+P ++  + V+RI+GG
Sbjct: 50  RYQCKN-YYRLRTEGDGVYTLNDKKQWINKAVGDKLPECEAVCGKP-KNPANPVQRILGG 107

Query: 454 RNAEPGLFPWQALIVVEDTSRVPNDKWFGSGALLSASWILTAAHVLRSQRRDTTVIPVSK 513
                G FPWQA +V                 L++  W+LT A  L     +        
Sbjct: 108 HLDAKGSFPWQAKMVSHHNLTT-------GATLINEQWLLTTAKNLFLNHSENATAKDIA 160

Query: 514 EHVTVYLGLHDVRDKSGAVNSSAARVVLHPDFNIQNYNHDIALVQLQEPVPLGPHVMPVC 573
             +T+Y+G   + +          +VVLHP++    +  DI L++L++ V +   VMP+C
Sbjct: 161 PTLTLYVGKKQLVE--------IEKVVLHPNY----HQVDIGLIKLKQKVLVNERVMPIC 208

Query: 574 LPRLEPEGPAPHMLGLVAGWGISNPNVTVDEIISSGTRTLSDVLQYVKLPVVPHAECKTS 633
           LP           +G V+GWG             S    L+D L+YV LPV    +C T 
Sbjct: 209 LP--SKNYAEVGRVGYVSGWG------------QSDNFKLTDHLKYVMLPVADQYDCITH 254

Query: 634 YESRSG------------NYSVTENMFCAGYYEGGKDTCLGDSGGAFVIFDDLSQRWVVQ 681
           YE  +                + E+ FC G  +  +DTC GD+G AF + D     W   
Sbjct: 255 YEGSTCPKWKAPKSPVGVQPILNEHTFCVGMSKYQEDTCYGDAGSAFAVHDLEEDTWYAA 314

Query: 682 GLVSWGGPEECGSKQVYGVYTKVSNYVDWV 711
           G++S+   + C   + YGVY KV++   WV
Sbjct: 315 GILSF--DKSCAVAE-YGVYVKVTSIQHWV 341


>gi|10518503 coagulation factor VII isoform b precursor [Homo
           sapiens]
          Length = 444

 Score =  138 bits (348), Expect = 2e-32
 Identities = 93/296 (31%), Positives = 140/296 (47%), Gaps = 41/296 (13%)

Query: 431 TCLPECGQPSRSLPSLVKR--------IIGGRNAEPGLFPWQALIVVEDTSRVPNDKWFG 482
           +C P    P   +P L KR        I+GG+    G  PWQ L++V       N     
Sbjct: 164 SCTPTVEYPCGKIPILEKRNASKPQGRIVGGKVCPKGECPWQVLLLV-------NGAQLC 216

Query: 483 SGALLSASWILTAAHVLRSQRRDTTVIPVSKEHVTVYLGLHDVRDKSGAVNSS-AARVVL 541
            G L++  W+++AAH     +    +I V        LG HD+ +  G   S   A+V++
Sbjct: 217 GGTLINTIWVVSAAHCFDKIKNWRNLIAV--------LGEHDLSEHDGDEQSRRVAQVII 268

Query: 542 HPDFNIQNYNHDIALVQLQEPVPLGPHVMPVCLPR--LEPEGPAPHMLGLVAGWGISNPN 599
              +     NHDIAL++L +PV L  HV+P+CLP         A     LV+GWG     
Sbjct: 269 PSTYVPGTTNHDIALLRLHQPVVLTDHVVPLCLPERTFSERTLAFVRFSLVSGWG----- 323

Query: 600 VTVDEIISSGTRTLSDVLQYVKLPVVPHAECKTSYESRSGNYSVTENMFCAGYYEGGKDT 659
               +++  G   L   L  + +P +   +C         + ++TE MFCAGY +G KD+
Sbjct: 324 ----QLLDRGATALE--LMVLNVPRLMTQDCLQQSRKVGDSPNITEYMFCAGYSDGSKDS 377

Query: 660 CLGDSGGAFVIFDDLSQRWVVQGLVSWGGPEECGSKQVYGVYTKVSNYVDWVWEQM 715
           C GDSGG           W + G+VSWG  + C +   +GVYT+VS Y++W+ + M
Sbjct: 378 CKGDSGGPHA--THYRGTWYLTGIVSWG--QGCATVGHFGVYTRVSQYIEWLQKLM 429


>gi|4503645 coagulation factor VII isoform a precursor [Homo
           sapiens]
          Length = 466

 Score =  138 bits (348), Expect = 2e-32
 Identities = 93/296 (31%), Positives = 140/296 (47%), Gaps = 41/296 (13%)

Query: 431 TCLPECGQPSRSLPSLVKR--------IIGGRNAEPGLFPWQALIVVEDTSRVPNDKWFG 482
           +C P    P   +P L KR        I+GG+    G  PWQ L++V       N     
Sbjct: 186 SCTPTVEYPCGKIPILEKRNASKPQGRIVGGKVCPKGECPWQVLLLV-------NGAQLC 238

Query: 483 SGALLSASWILTAAHVLRSQRRDTTVIPVSKEHVTVYLGLHDVRDKSGAVNSS-AARVVL 541
            G L++  W+++AAH     +    +I V        LG HD+ +  G   S   A+V++
Sbjct: 239 GGTLINTIWVVSAAHCFDKIKNWRNLIAV--------LGEHDLSEHDGDEQSRRVAQVII 290

Query: 542 HPDFNIQNYNHDIALVQLQEPVPLGPHVMPVCLPR--LEPEGPAPHMLGLVAGWGISNPN 599
              +     NHDIAL++L +PV L  HV+P+CLP         A     LV+GWG     
Sbjct: 291 PSTYVPGTTNHDIALLRLHQPVVLTDHVVPLCLPERTFSERTLAFVRFSLVSGWG----- 345

Query: 600 VTVDEIISSGTRTLSDVLQYVKLPVVPHAECKTSYESRSGNYSVTENMFCAGYYEGGKDT 659
               +++  G   L   L  + +P +   +C         + ++TE MFCAGY +G KD+
Sbjct: 346 ----QLLDRGATALE--LMVLNVPRLMTQDCLQQSRKVGDSPNITEYMFCAGYSDGSKDS 399

Query: 660 CLGDSGGAFVIFDDLSQRWVVQGLVSWGGPEECGSKQVYGVYTKVSNYVDWVWEQM 715
           C GDSGG           W + G+VSWG  + C +   +GVYT+VS Y++W+ + M
Sbjct: 400 CKGDSGGPHA--THYRGTWYLTGIVSWG--QGCATVGHFGVYTRVSQYIEWLQKLM 451


>gi|23957702 transmembrane protease, serine 6 [Homo sapiens]
          Length = 811

 Score =  136 bits (343), Expect = 6e-32
 Identities = 91/265 (34%), Positives = 129/265 (48%), Gaps = 36/265 (13%)

Query: 449 RIIGGRNAEPGLFPWQALIVVEDTSRVPNDKWFGSGALLSASWILTAAHVLRSQRRDTTV 508
           RI+GG  +  G +PWQA + V         +    GAL++  W++TAAH  +     +TV
Sbjct: 576 RIVGGAVSSEGEWPWQASLQVRG-------RHICGGALIADRWVITAAHCFQEDSMASTV 628

Query: 509 IPVSKEHVTVYLGLHDVRDK-SGAVNSSAARVVLHPDFNIQNYNHDIALVQLQEPVPLGP 567
           +       TV+LG      +  G V+   +R++LHP     ++++D+AL+QL  PV    
Sbjct: 629 L------WTVFLGKVWQNSRWPGEVSFKVSRLLLHPYHEEDSHDYDVALLQLDHPVVRSA 682

Query: 568 HVMPVCLP-RLEPEGPAPHMLGLVAGWGISNPNVTVDEIISSGTRTLSDVLQYVKLPVVP 626
            V PVCLP R     P  H    + GWG                  +S+ LQ V + ++P
Sbjct: 683 AVRPVCLPARSHFFEPGLHC--WITGWGALREG-----------GPISNALQKVDVQLIP 729

Query: 627 HAECKTSYESRSGNYSVTENMFCAGYYEGGKDTCLGDSGGAFVIFDDLSQRWVVQGLVSW 686
              C   Y      Y VT  M CAGY +G KD C GDSGG  V    LS RW + GLVSW
Sbjct: 730 QDLCSEVY-----RYQVTPRMLCAGYRKGKKDACQGDSGGPLVC-KALSGRWFLAGLVSW 783

Query: 687 GGPEECGSKQVYGVYTKVSNYVDWV 711
           G    CG    +GVYT+++  + W+
Sbjct: 784 G--LGCGRPNYFGVYTRITGVISWI 806


>gi|4506115 protein C [Homo sapiens]
          Length = 461

 Score =  135 bits (341), Expect = 1e-31
 Identities = 92/268 (34%), Positives = 131/268 (48%), Gaps = 38/268 (14%)

Query: 449 RIIGGRNAEPGLFPWQALIVVEDTSRVPNDKWFGSGA-LLSASWILTAAHVLRSQRRDTT 507
           R+I G+    G  PWQ +++        + K    GA L+  SW+LTAAH +   ++   
Sbjct: 211 RLIDGKMTRRGDSPWQVVLL-------DSKKKLACGAVLIHPSWVLTAAHCMDESKK--- 260

Query: 508 VIPVSKEHVTVYLGLHDVRD-KSGAVNSSAARVVLHPDFNIQNYNHDIALVQLQEPVPLG 566
                   + V LG +D+R  +   ++     V +HP+++    ++DIAL+ L +P  L 
Sbjct: 261 --------LLVRLGEYDLRRWEKWELDLDIKEVFVHPNYSKSTTDNDIALLHLAQPATLS 312

Query: 567 PHVMPVCLP---RLEPEGPAPHMLGLVAGWGISNPNVTVDEIISSGTRTLSDVLQYVKLP 623
             ++P+CLP     E E        LV GWG  +             R  + VL ++K+P
Sbjct: 313 QTIVPICLPDSGLAERELNQAGQETLVTGWGYHSSRE------KEAKRNRTFVLNFIKIP 366

Query: 624 VVPHAECKTSYESRSGNYSVTENMFCAGYYEGGKDTCLGDSGGAFVIFDDLSQRWVVQGL 683
           VVPH EC     S   +  V+ENM CAG     +D C GDSGG  V        W + GL
Sbjct: 367 VVPHNEC-----SEVMSNMVSENMLCAGILGDRQDACEGDSGGPMVA--SFHGTWFLVGL 419

Query: 684 VSWGGPEECGSKQVYGVYTKVSNYVDWV 711
           VSWG  E CG    YGVYTKVS Y+DW+
Sbjct: 420 VSWG--EGCGLLHNYGVYTKVSRYLDWI 445



 Score = 30.4 bits (67), Expect = 6.1
 Identities = 13/29 (44%), Positives = 14/29 (48%)

Query: 153 CDHYCHNYIGGYYCSCRFGYILHTDNRTC 181
           C HYC   +G   CSC  GY L  D   C
Sbjct: 147 CTHYCLEEVGWRRCSCAPGYKLGDDLLQC 175


>gi|33667063 transmembrane protease, serine 9 [Homo sapiens]
          Length = 1059

 Score =  135 bits (341), Expect = 1e-31
 Identities = 90/281 (32%), Positives = 139/281 (49%), Gaps = 39/281 (13%)

Query: 435 ECG-QPSRSLPSLVKRIIGGRNAEPGLFPWQALIVVEDTSRVPNDKWFGSGALLSASWIL 493
           ECG QP+  +     RI+GG  A PG FPWQA       S   N + F   A+++A W++
Sbjct: 190 ECGLQPAWRMAG---RIVGGMEASPGEFPWQA-------SLRENKEHFCGAAIINARWLV 239

Query: 494 TAAHVLRSQRRDTTVIPVSKEHVTVYLGLHDVR-DKSGAVNSSAARVVLHPDFNIQNYNH 552
           +AAH     +  T  +         Y+G   +   ++  V +   ++V HP +N    + 
Sbjct: 240 SAAHCFNEFQDPTKWV--------AYVGATYLSGSEASTVRAQVVQIVKHPLYNADTADF 291

Query: 553 DIALVQLQEPVPLGPHVMPVCLPRLEPEGPAPHMLGLVAGWGISNPNVTVDEIISSGTRT 612
           D+A+++L  P+P G H+ PVCLP      P P    L++GWG    +  V          
Sbjct: 292 DVAVLELTSPLPFGRHIQPVCLPAATHIFP-PSKKCLISGWGYLKEDFLVK--------- 341

Query: 613 LSDVLQYVKLPVVPHAECKTSYESRSGNYSVTENMFCAGYYEGGKDTCLGDSGGAFVIFD 672
             +VLQ   + ++  A C + Y      +S+T+ M CAGY +G  D+C GDSGG  V  +
Sbjct: 342 -PEVLQKATVELLDQALCASLY-----GHSLTDRMVCAGYLDGKVDSCQGDSGGPLVC-E 394

Query: 673 DLSQRWVVQGLVSWGGPEECGSKQVYGVYTKVSNYVDWVWE 713
           + S R+ + G+VSWG    C   +  GVY +V+   DW+ E
Sbjct: 395 EPSGRFFLAGIVSWG--IGCAEARRPGVYARVTRLRDWILE 433



 Score =  118 bits (295), Expect = 2e-26
 Identities = 85/293 (29%), Positives = 133/293 (45%), Gaps = 43/293 (14%)

Query: 433 LPECG-QPSRSLPSLVKRIIGGRNAEPGLFPWQALIVVEDTSRVPNDKWFGSGALLSASW 491
           L ECG +P+   P+   R++GG  A  G  PWQ        S     + F    ++   W
Sbjct: 489 LQECGARPAMEKPT---RVVGGFGAASGEVPWQV-------SLKEGSRHFCGATVVGDRW 538

Query: 492 ILTAAHVLRSQRRDTTVIPVSKEHVTVYLGLHDVRDKSGA-VNSSAARVVLHPDFNIQNY 550
           +L+AAH     +          E V  +LG   +    G+ V     RVVLHP +N    
Sbjct: 539 LLSAAHCFNHTK---------VEQVRAHLGTASLLGLGGSPVKIGLRRVVLHPLYNPGIL 589

Query: 551 NHDIALVQLQEPVPLGPHVMPVCLPRLEPEGPAPHMLGLVAGWGISNPNVTVDEIISSGT 610
           + D+A+++L  P+    ++ PVCLP    + P      +++GWG +            G 
Sbjct: 590 DFDLAVLELASPLAFNKYIQPVCLPLAIQKFPVGRKC-MISGWGNTQ----------EGN 638

Query: 611 RTLSDVLQYVKLPVVPHAECKTSYESRSGNYSVTENMFCAGYYEGGKDTCLGDSGGAFVI 670
            T  ++LQ   + ++    C   Y     N+S+T+ M CAG+ EG  D+C GDSGG    
Sbjct: 639 ATKPELLQKASVGIIDQKTCSVLY-----NFSLTDRMICAGFLEGKVDSCQGDSGGPLAC 693

Query: 671 FDDLSQRWVVQGLVSWGGPEECGSKQVYGVYTKVSNYVDWVWEQMG---LPQS 720
            ++    + + G+VSWG    C   +  GVYT+++    W+ E M    LP S
Sbjct: 694 -EEAPGVFYLAGIVSWG--IGCAQVKKPGVYTRITRLKGWILEIMSSQPLPMS 743



 Score =  108 bits (270), Expect = 2e-23
 Identities = 81/286 (28%), Positives = 129/286 (45%), Gaps = 41/286 (14%)

Query: 431  TCLPECGQPSRSLPSLVKRIIGGRNAEPGLFPWQALIVVEDTSRVPNDKWFGSGALLSAS 490
            T LP+CG      P+ + RI+GG  A  G +PWQ  + +              GA+L A 
Sbjct: 812  TQLPDCGLA----PAALTRIVGGSAAGRGEWPWQVSLWLRRREH-------RCGAVLVAE 860

Query: 491  -WILTAAHVLRSQRRDTTVIPVSKEHVTVYLGLHDVRDKSGAVNSSAARVVLHPDFNIQN 549
             W+L+AAH           +    +    +LG   +    G +    AR+  HP +N+  
Sbjct: 861  RWLLSAAHCFD--------VYGDPKQWAAFLGTPFLSGAEGQLER-VARIYKHPFYNLYT 911

Query: 550  YNHDIALVQLQEPVPLGPHVMPVCLPRLEPEGPAPHMLGLVAGWGISNPNVTVDEIISSG 609
             ++D+AL++L  PV     V P+CLP   P  P      ++ GWG          +   G
Sbjct: 912  LDYDVALLELAGPVRRSRLVRPICLPEPAPR-PPDGTRCVITGWG---------SVREGG 961

Query: 610  TRTLSDVLQYVKLPVVPHAECKTSYESRSGNYSVTENMFCAGYYEGGKDTCLGDSGGAFV 669
              +++  LQ   + ++    C+  Y        ++  M CAG+ +GG D+C GD+GG   
Sbjct: 962  --SMARQLQKAAVRLLSEQTCRRFYP-----VQISSRMLCAGFPQGGVDSCSGDAGGPLA 1014

Query: 670  IFDDLSQRWVVQGLVSWGGPEECGSKQVYGVYTKVSNYVDWVWEQM 715
              +  S RWV+ G+ SWG    CG     GVYT+V+    W+ + +
Sbjct: 1015 CREP-SGRWVLTGVTSWG--YGCGRPHFPGVYTRVAAVRGWIGQHI 1057


>gi|4506147 protease, serine, 2 preproprotein [Homo sapiens]
          Length = 247

 Score =  135 bits (340), Expect = 1e-31
 Identities = 89/264 (33%), Positives = 129/264 (48%), Gaps = 48/264 (18%)

Query: 449 RIIGGRNAEPGLFPWQALIVVEDTSRVPNDKWFGSGALLSASWILTAAHVLRSQRRDTTV 508
           +I+GG   E    P+Q  +         +   F  G+L+S  W+++A H  +S+      
Sbjct: 23  KIVGGYICEENSVPYQVSL--------NSGYHFCGGSLISEQWVVSAGHCYKSR------ 68

Query: 509 IPVSKEHVTVYLGLHDVRDKSGAVNS-SAARVVLHPDFNIQNYNHDIALVQLQEPVPLGP 567
                  + V LG H++    G     +AA+++ HP +N +  ++DI L++L  P  +  
Sbjct: 69  -------IQVRLGEHNIEVLEGNEQFINAAKIIRHPKYNSRTLDNDILLIKLSSPAVINS 121

Query: 568 HVMPVCLPRLEPEGPAPHMLGLVAGWGISNPNVTVDEIISSGTRTLSDVLQYVKLPVVPH 627
            V  + LP   P   A     L++GWG           +SSG     D LQ +  PV+  
Sbjct: 122 RVSAISLPTAPP---AAGTESLISGWG---------NTLSSGA-DYPDELQCLDAPVLSQ 168

Query: 628 AECKTSYESRSGNYSVTENMFCAGYYEGGKDTCLGDSGGAFVIFDDLSQRWVVQGLVSWG 687
           AEC+ SY  +     +T NMFC G+ EGGKD+C GDSGG  V   +L      QG+VSWG
Sbjct: 169 AECEASYPGK-----ITNNMFCVGFLEGGKDSCQGDSGGPVVSNGEL------QGIVSWG 217

Query: 688 GPEECGSKQVYGVYTKVSNYVDWV 711
               C  K   GVYTKV NYVDW+
Sbjct: 218 --YGCAQKNRPGVYTKVYNYVDWI 239


>gi|4506153 prostasin preproprotein [Homo sapiens]
          Length = 343

 Score =  134 bits (338), Expect = 2e-31
 Identities = 90/283 (31%), Positives = 131/283 (46%), Gaps = 33/283 (11%)

Query: 449 RIIGGRNAEPGLFPWQALIVVEDTSRVPNDKWFGSGALLSASWILTAAHVLRSQRRDTTV 508
           RI GG +A  G +PWQ  I  E             G+L+S  W+L+AAH   S+      
Sbjct: 44  RITGGSSAVAGQWPWQVSITYEGVHVC-------GGSLVSEQWVLSAAHCFPSEHH---- 92

Query: 509 IPVSKEHVTVYLGLHDVRDKSGAVNSSAAR-VVLHPDFNIQNYNHDIALVQLQEPVPLGP 567
               KE   V LG H +   S     S  + ++ HP +  +    DIAL+QL  P+    
Sbjct: 93  ----KEAYEVKLGAHQLDSYSEDAKVSTLKDIIPHPSYLQEGSQGDIALLQLSRPITFSR 148

Query: 568 HVMPVCLPRLEPEGPAPHMLGLVAGWGISNPNVTVDEIISSGTRTLSDVLQYVKLPVVPH 627
           ++ P+CLP      P   +   V GWG   P+V++              LQ +++P++  
Sbjct: 149 YIRPICLPAANASFPNG-LHCTVTGWGHVAPSVSL---------LTPKPLQQLEVPLISR 198

Query: 628 AECKTSYE---SRSGNYSVTENMFCAGYYEGGKDTCLGDSGGAFVIFDDLSQRWVVQGLV 684
             C   Y         + V E+M CAGY EGGKD C GDSGG   +   +   W + G+V
Sbjct: 199 ETCNCLYNIDAKPEEPHFVQEDMVCAGYVEGGKDACQGDSGGP--LSCPVEGLWYLTGIV 256

Query: 685 SWGGPEECGSKQVYGVYTKVSNYVDWVWEQMGLPQSVVEPQVE 727
           SWG  + CG++   GVYT  S+Y  W+  ++   Q  V PQ +
Sbjct: 257 SWG--DACGARNRPGVYTLASSYASWIQSKVTELQPRVVPQTQ 297


>gi|33695155 hepsin [Homo sapiens]
          Length = 417

 Score =  131 bits (329), Expect = 3e-30
 Identities = 99/296 (33%), Positives = 140/296 (47%), Gaps = 44/296 (14%)

Query: 426 GRSLPTCLPECGQPSRSLPSLVKRIIGGRNAEPGLFPWQALIVVEDTSRVPNDKWFGSGA 485
           GR L     +CG+  R LP  V RI+GGR+   G +PWQ  +  +             G+
Sbjct: 143 GRFLAAICQDCGR--RKLP--VDRIVGGRDTSLGRWPWQVSLRYDGAHLC-------GGS 191

Query: 486 LLSASWILTAAHVLRSQRRDTTVIPVSKEHVTVYLGLHDVRDKSGAVNSSAARVVLHPDF 545
           LLS  W+LTAAH    + R  +          V+ G        G +      VV H  +
Sbjct: 192 LLSGDWVLTAAHCFPERNRVLS-------RWRVFAGAVAQASPHG-LQLGVQAVVYHGGY 243

Query: 546 ------NIQNYNHDIALVQLQEPVPLGPHVMPVCLPRLEPEGPAPHMLGLVAGWGISNPN 599
                 N +  ++DIALV L  P+PL  ++ PVCLP    +      +  V GWG  N  
Sbjct: 244 LPFRDPNSEENSNDIALVHLSSPLPLTEYIQPVCLPAAG-QALVDGKICTVTGWG--NTQ 300

Query: 600 VTVDEIISSGTRTLSDVLQYVKLPVVPHAECKTSYESRSGNYSVTENMFCAGYYEGGKDT 659
               +         + VLQ  ++P++ +  C  +     GN  +   MFCAGY EGG D 
Sbjct: 301 YYGQQ---------AGVLQEARVPIISNDVCNGA--DFYGN-QIKPKMFCAGYPEGGIDA 348

Query: 660 CLGDSGGAFVIFDDLSQ--RWVVQGLVSWGGPEECGSKQVYGVYTKVSNYVDWVWE 713
           C GDSGG FV  D +S+  RW + G+VSWG    C   Q  GVYTKVS++ +W+++
Sbjct: 349 CQGDSGGPFVCEDSISRTPRWRLCGIVSWG--TGCALAQKPGVYTKVSDFREWIFQ 402


>gi|4504481 hepsin [Homo sapiens]
          Length = 417

 Score =  131 bits (329), Expect = 3e-30
 Identities = 99/296 (33%), Positives = 140/296 (47%), Gaps = 44/296 (14%)

Query: 426 GRSLPTCLPECGQPSRSLPSLVKRIIGGRNAEPGLFPWQALIVVEDTSRVPNDKWFGSGA 485
           GR L     +CG+  R LP  V RI+GGR+   G +PWQ  +  +             G+
Sbjct: 143 GRFLAAICQDCGR--RKLP--VDRIVGGRDTSLGRWPWQVSLRYDGAHLC-------GGS 191

Query: 486 LLSASWILTAAHVLRSQRRDTTVIPVSKEHVTVYLGLHDVRDKSGAVNSSAARVVLHPDF 545
           LLS  W+LTAAH    + R  +          V+ G        G +      VV H  +
Sbjct: 192 LLSGDWVLTAAHCFPERNRVLS-------RWRVFAGAVAQASPHG-LQLGVQAVVYHGGY 243

Query: 546 ------NIQNYNHDIALVQLQEPVPLGPHVMPVCLPRLEPEGPAPHMLGLVAGWGISNPN 599
                 N +  ++DIALV L  P+PL  ++ PVCLP    +      +  V GWG  N  
Sbjct: 244 LPFRDPNSEENSNDIALVHLSSPLPLTEYIQPVCLPAAG-QALVDGKICTVTGWG--NTQ 300

Query: 600 VTVDEIISSGTRTLSDVLQYVKLPVVPHAECKTSYESRSGNYSVTENMFCAGYYEGGKDT 659
               +         + VLQ  ++P++ +  C  +     GN  +   MFCAGY EGG D 
Sbjct: 301 YYGQQ---------AGVLQEARVPIISNDVCNGA--DFYGN-QIKPKMFCAGYPEGGIDA 348

Query: 660 CLGDSGGAFVIFDDLSQ--RWVVQGLVSWGGPEECGSKQVYGVYTKVSNYVDWVWE 713
           C GDSGG FV  D +S+  RW + G+VSWG    C   Q  GVYTKVS++ +W+++
Sbjct: 349 CQGDSGGPFVCEDSISRTPRWRLCGIVSWG--TGCALAQKPGVYTKVSDFREWIFQ 402


  Database: hs.faa
    Posted date:  Aug 4, 2009  4:42 PM
  Number of letters in database: 18,247,518
  Number of sequences in database:  37,866
  
Lambda     K      H
   0.319    0.136    0.433 

Gapped
Lambda     K      H
   0.267   0.0410    0.140 


Matrix: BLOSUM62
Gap Penalties: Existence: 11, Extension: 1
Number of Hits to DB: 32,212,236
Number of Sequences: 37866
Number of extensions: 1595076
Number of successful extensions: 5883
Number of sequences better than 10.0: 30
Number of HSP's better than 10.0 without gapping: 283
Number of HSP's successfully gapped in prelim test: 108
Number of HSP's that attempted gapping in prelim test: 3432
Number of HSP's gapped (non-prelim): 1516
length of query: 728
length of database: 18,247,518
effective HSP length: 110
effective length of query: 618
effective length of database: 14,082,258
effective search space: 8702835444
effective search space used: 8702835444
T: 11
A: 40
X1: 16 ( 7.4 bits)
X2: 38 (14.6 bits)
X3: 64 (24.7 bits)
S1: 41 (21.7 bits)
S2: 66 (30.0 bits)
Search results were obtained with NCBI BLAST and RefSeq entries.