Search of human proteins with 21264357

Search of human proteins with 21264357

BLASTP 2.2.11 [Jun-05-2005]


Reference: Altschul, Stephen F., Thomas L. Madden, Alejandro A. Schaffer, 
Jinghui Zhang, Zheng Zhang, Webb Miller, and David J. Lipman (1997), 
"Gapped BLAST and PSI-BLAST: a new generation of protein database search
programs",  Nucleic Acids Res. 25:3389-3402.

Query= gi|21264357 mannan-binding lectin serine protease 1 isoform 1
precursor [Homo sapiens]
         (699 letters)

Database: hs.faa 
           37,866 sequences; 18,247,518 total letters

Searching..................................................done

                                                                 Score    E
Sequences producing significant alignments:                      (bits) Value

gi|21264357 mannan-binding lectin serine protease 1 isoform 1 pr...  1484   0.0  
gi|21264359 mannan-binding lectin serine protease 1 isoform 2 pr...  1070   0.0  
gi|73623026 mannan-binding lectin serine protease 1 isoform 3 [H...   777   0.0  
gi|21264363 mannan-binding lectin serine protease 2 isoform 1 pr...   588   e-168
gi|66347875 complement component 1, r subcomponent [Homo sapiens]     491   e-138
gi|4502495 complement component 1, s subcomponent precursor [Hom...   443   e-124
gi|41393602 complement component 1, s subcomponent precursor [Ho...   443   e-124
gi|21264361 mannan-binding lectin serine protease 2 isoform 2 pr...   207   3e-53
gi|11415040 matriptase [Homo sapiens]                                 186   5e-47
gi|5453579 bone morphogenetic protein 1 isoform 3 precursor [Hom...   172   9e-43
gi|6912724 tolloid-like 2 [Homo sapiens]                              170   4e-42
gi|22547221 tolloid-like 1 [Homo sapiens]                             167   2e-41
gi|4826762 haptoglobin isoform 1 preproprotein [Homo sapiens]         159   6e-39
gi|187761337 transmembrane protease, serine 11B [Homo sapiens]        155   1e-37
gi|13994276 marapsin [Homo sapiens]                                   154   3e-37
gi|4506115 protein C [Homo sapiens]                                   153   5e-37
gi|4502421 bone morphogenetic protein 1 isoform 1 precursor [Hom...   153   6e-37
gi|4506145 protease, serine, 1 preproprotein [Homo sapiens]           151   2e-36
gi|4758508 transmembrane protease, serine 11D [Homo sapiens]          151   2e-36
gi|186910296 haptoglobin isoform 2 preproprotein [Homo sapiens]       150   3e-36
gi|4503649 coagulation factor IX preproprotein [Homo sapiens]         149   1e-35
gi|23957702 transmembrane protease, serine 6 [Homo sapiens]           148   1e-35
gi|4506147 protease, serine, 2 preproprotein [Homo sapiens]           147   2e-35
gi|5902808 bone morphogenetic protein 1 isoform 2 precursor [Hom...   147   2e-35
gi|170296790 mesotrypsin isoform 1 preproprotein [Homo sapiens]       147   2e-35
gi|21536452 mesotrypsin isoform 2 preproprotein [Homo sapiens]        147   2e-35
gi|11545839 protease, serine, 22 [Homo sapiens]                       147   2e-35
gi|4503635 coagulation factor II preproprotein [Homo sapiens]         147   3e-35
gi|145275213 coagulation factor XII precursor [Homo sapiens]          147   3e-35
gi|4503627 coagulation factor XI precursor [Homo sapiens]             147   3e-35

>gi|21264357 mannan-binding lectin serine protease 1 isoform 1
           precursor [Homo sapiens]
          Length = 699

 Score = 1484 bits (3842), Expect = 0.0
 Identities = 699/699 (100%), Positives = 699/699 (100%)

Query: 1   MRWLLLYYALCFSLSKASAHTVELNNMFGQIQSPGYPDSYPSDSEVTWNITVPDGFRIKL 60
           MRWLLLYYALCFSLSKASAHTVELNNMFGQIQSPGYPDSYPSDSEVTWNITVPDGFRIKL
Sbjct: 1   MRWLLLYYALCFSLSKASAHTVELNNMFGQIQSPGYPDSYPSDSEVTWNITVPDGFRIKL 60

Query: 61  YFMHFNLESSYLCEYDYVKVETEDQVLATFCGRETTDTEQTPGQEVVLSPGSFMSITFRS 120
           YFMHFNLESSYLCEYDYVKVETEDQVLATFCGRETTDTEQTPGQEVVLSPGSFMSITFRS
Sbjct: 61  YFMHFNLESSYLCEYDYVKVETEDQVLATFCGRETTDTEQTPGQEVVLSPGSFMSITFRS 120

Query: 121 DFSNEERFTGFDAHYMAVDVDECKEREDEELSCDHYCHNYIGGYYCSCRFGYILHTDNRT 180
           DFSNEERFTGFDAHYMAVDVDECKEREDEELSCDHYCHNYIGGYYCSCRFGYILHTDNRT
Sbjct: 121 DFSNEERFTGFDAHYMAVDVDECKEREDEELSCDHYCHNYIGGYYCSCRFGYILHTDNRT 180

Query: 181 CRVECSDNLFTQRTGVITSPDFPNPYPKSSECLYTIELEEGFMVNLQFEDIFDIEDHPEV 240
           CRVECSDNLFTQRTGVITSPDFPNPYPKSSECLYTIELEEGFMVNLQFEDIFDIEDHPEV
Sbjct: 181 CRVECSDNLFTQRTGVITSPDFPNPYPKSSECLYTIELEEGFMVNLQFEDIFDIEDHPEV 240

Query: 241 PCPYDYIKIKVGPKVLGPFCGEKAPEPISTQSHSVLILFHSDNSGENRGWRLSYRAAGNE 300
           PCPYDYIKIKVGPKVLGPFCGEKAPEPISTQSHSVLILFHSDNSGENRGWRLSYRAAGNE
Sbjct: 241 PCPYDYIKIKVGPKVLGPFCGEKAPEPISTQSHSVLILFHSDNSGENRGWRLSYRAAGNE 300

Query: 301 CPELQPPVHGKIEPSQAKYFFKDQVLVSCDTGYKVLKDNVEMDTFQIECLKDGTWSNKIP 360
           CPELQPPVHGKIEPSQAKYFFKDQVLVSCDTGYKVLKDNVEMDTFQIECLKDGTWSNKIP
Sbjct: 301 CPELQPPVHGKIEPSQAKYFFKDQVLVSCDTGYKVLKDNVEMDTFQIECLKDGTWSNKIP 360

Query: 361 TCKIVDCRAPGELEHGLITFSTRNNLTTYKSEIKYSCQEPYYKMLNNNTGIYTCSAQGVW 420
           TCKIVDCRAPGELEHGLITFSTRNNLTTYKSEIKYSCQEPYYKMLNNNTGIYTCSAQGVW
Sbjct: 361 TCKIVDCRAPGELEHGLITFSTRNNLTTYKSEIKYSCQEPYYKMLNNNTGIYTCSAQGVW 420

Query: 421 MNKVLGRSLPTCLPVCGLPKFSRKLMARIFNGRPAQKGTTPWIAMLSHLNGQPFCGGSLL 480
           MNKVLGRSLPTCLPVCGLPKFSRKLMARIFNGRPAQKGTTPWIAMLSHLNGQPFCGGSLL
Sbjct: 421 MNKVLGRSLPTCLPVCGLPKFSRKLMARIFNGRPAQKGTTPWIAMLSHLNGQPFCGGSLL 480

Query: 481 GSSWIVTAAHCLHQSLDPEDPTLRDSDLLSPSDFKIILGKHWRLRSDENEQHLGVKHTTL 540
           GSSWIVTAAHCLHQSLDPEDPTLRDSDLLSPSDFKIILGKHWRLRSDENEQHLGVKHTTL
Sbjct: 481 GSSWIVTAAHCLHQSLDPEDPTLRDSDLLSPSDFKIILGKHWRLRSDENEQHLGVKHTTL 540

Query: 541 HPQYDPNTFENDVALVELLESPVLNAFVMPICLPEGPQQEGAMVIVSGWGKQFLQRFPET 600
           HPQYDPNTFENDVALVELLESPVLNAFVMPICLPEGPQQEGAMVIVSGWGKQFLQRFPET
Sbjct: 541 HPQYDPNTFENDVALVELLESPVLNAFVMPICLPEGPQQEGAMVIVSGWGKQFLQRFPET 600

Query: 601 LMEIEIPIVDHSTCQKAYAPLKKKVTRDMICAGEKEGGKDACAGDSGGPMVTLNRERGQW 660
           LMEIEIPIVDHSTCQKAYAPLKKKVTRDMICAGEKEGGKDACAGDSGGPMVTLNRERGQW
Sbjct: 601 LMEIEIPIVDHSTCQKAYAPLKKKVTRDMICAGEKEGGKDACAGDSGGPMVTLNRERGQW 660

Query: 661 YLVGTVSWGDDCGKKDRYGVYSYIHHNKDWIQRVTGVRN 699
           YLVGTVSWGDDCGKKDRYGVYSYIHHNKDWIQRVTGVRN
Sbjct: 661 YLVGTVSWGDDCGKKDRYGVYSYIHHNKDWIQRVTGVRN 699


>gi|21264359 mannan-binding lectin serine protease 1 isoform 2
           precursor [Homo sapiens]
          Length = 728

 Score = 1070 bits (2767), Expect = 0.0
 Identities = 532/726 (73%), Positives = 577/726 (79%), Gaps = 38/726 (5%)

Query: 1   MRWLLLYYALCFSLSKASAHTVELNNMFGQIQSPGYPDSYPSDSEVTWNITVPDGFRIKL 60
           MRWLLLYYALCFSLSKASAHTVELNNMFGQIQSPGYPDSYPSDSEVTWNITVPDGFRIKL
Sbjct: 1   MRWLLLYYALCFSLSKASAHTVELNNMFGQIQSPGYPDSYPSDSEVTWNITVPDGFRIKL 60

Query: 61  YFMHFNLESSYLCEYDYVKVETEDQVLATFCGRETTDTEQTPGQEVVLSPGSFMSITFRS 120
           YFMHFNLESSYLCEYDYVKVETEDQVLATFCGRETTDTEQTPGQEVVLSPGSFMSITFRS
Sbjct: 61  YFMHFNLESSYLCEYDYVKVETEDQVLATFCGRETTDTEQTPGQEVVLSPGSFMSITFRS 120

Query: 121 DFSNEERFTGFDAHYMAVDVDECKEREDEELSCDHYCHNYIGGYYCSCRFGYILHTDNRT 180
           DFSNEERFTGFDAHYMAVDVDECKEREDEELSCDHYCHNYIGGYYCSCRFGYILHTDNRT
Sbjct: 121 DFSNEERFTGFDAHYMAVDVDECKEREDEELSCDHYCHNYIGGYYCSCRFGYILHTDNRT 180

Query: 181 CRVECSDNLFTQRTGVITSPDFPNPYPKSSECLYTIELEEGFMVNLQFEDIFDIEDHPEV 240
           CRVECSDNLFTQRTGVITSPDFPNPYPKSSECLYTIELEEGFMVNLQFEDIFDIEDHPEV
Sbjct: 181 CRVECSDNLFTQRTGVITSPDFPNPYPKSSECLYTIELEEGFMVNLQFEDIFDIEDHPEV 240

Query: 241 PCPYDYIKIKVGPKVLGPFCGEKAPEPISTQSHSVLILFHSDNSGENRGWRLSYRAAGNE 300
           PCPYDYIKIKVGPKVLGPFCGEKAPEPISTQSHSVLILFHSDNSGENRGWRLSYRAAGNE
Sbjct: 241 PCPYDYIKIKVGPKVLGPFCGEKAPEPISTQSHSVLILFHSDNSGENRGWRLSYRAAGNE 300

Query: 301 CPELQPPVHGKIEPSQAKYFFKDQVLVSCDTGYKVLKDNVEMDTFQIECLKDGTWSNKIP 360
           CPELQPPVHGKIEPSQAKYFFKDQVLVSCDTGYKVLKDNVEMDTFQIECLKDGTWSNKIP
Sbjct: 301 CPELQPPVHGKIEPSQAKYFFKDQVLVSCDTGYKVLKDNVEMDTFQIECLKDGTWSNKIP 360

Query: 361 TCKIVDCRAPGELEHGLITFSTRNNLTTYKSEIKYSCQEPYYKMLNNNTGIYTCSAQGVW 420
           TCKIVDCRAPGELEHGLITFSTRNNLTTYKSEIKYSCQEPYYKMLNNNTGIYTCSAQGVW
Sbjct: 361 TCKIVDCRAPGELEHGLITFSTRNNLTTYKSEIKYSCQEPYYKMLNNNTGIYTCSAQGVW 420

Query: 421 MNKVLGRSLPTCLPVCGLPKFS-RKLMARIFNGRPAQKGTTPWIAML-----SHL-NGQP 473
           MNKVLGRSLPTCLP CG P  S   L+ RI  GR A+ G  PW A++     S + N + 
Sbjct: 421 MNKVLGRSLPTCLPECGQPSRSLPSLVKRIIGGRNAEPGLFPWQALIVVEDTSRVPNDKW 480

Query: 474 FCGGSLLGSSWIVTAAHCLHQSLDPEDPTLRDSDLL--SPSDFKIILGKHWRLRSDENEQ 531
           F  G+LL +SWI+TAAH L           RD+ ++  S     + LG H  +R      
Sbjct: 481 FGSGALLSASWILTAAHVLRSQ-------RRDTTVIPVSKEHVTVYLGLH-DVRDKSGAV 532

Query: 532 HLGVKHTTLHPQYDPNTFENDVALVELLESPVLNAFVMPICL----PEGPQQEGAMVIVS 587
           +       LHP ++   + +D+ALV+L E   L   VMP+CL    PEGP     + +V+
Sbjct: 533 NSSAARVVLHPDFNIQNYNHDIALVQLQEPVPLGPHVMPVCLPRLEPEGPAPH-MLGLVA 591

Query: 588 GWG------------KQFLQRFPETLMEIEIPIVDHSTCQKAYAPL--KKKVTRDMICAG 633
           GWG                +   + L  +++P+V H+ C+ +Y        VT +M CAG
Sbjct: 592 GWGISNPNVTVDEIISSGTRTLSDVLQYVKLPVVPHAECKTSYESRSGNYSVTENMFCAG 651

Query: 634 EKEGGKDACAGDSGGPMVTLNRERGQWYLVGTVSWG--DDCGKKDRYGVYSYIHHNKDWI 691
             EGGKD C GDSGG  V  +    +W + G VSWG  ++CG K  YGVY+ + +  DW+
Sbjct: 652 YYEGGKDTCLGDSGGAFVIFDDLSQRWVVQGLVSWGGPEECGSKQVYGVYTKVSNYVDWV 711

Query: 692 QRVTGV 697
               G+
Sbjct: 712 WEQMGL 717


>gi|73623026 mannan-binding lectin serine protease 1 isoform 3 [Homo
           sapiens]
          Length = 380

 Score =  777 bits (2007), Expect = 0.0
 Identities = 366/379 (96%), Positives = 369/379 (97%)

Query: 1   MRWLLLYYALCFSLSKASAHTVELNNMFGQIQSPGYPDSYPSDSEVTWNITVPDGFRIKL 60
           MRWLLLYYALCFSLSKASAHTVELNNMFGQIQSPGYPDSYPSDSEVTWNITVPDGFRIKL
Sbjct: 1   MRWLLLYYALCFSLSKASAHTVELNNMFGQIQSPGYPDSYPSDSEVTWNITVPDGFRIKL 60

Query: 61  YFMHFNLESSYLCEYDYVKVETEDQVLATFCGRETTDTEQTPGQEVVLSPGSFMSITFRS 120
           YFMHFNLESSYLCEYDYVKVETEDQVLATFCGRETTDTEQTPGQEVVLSPGSFMSITFRS
Sbjct: 61  YFMHFNLESSYLCEYDYVKVETEDQVLATFCGRETTDTEQTPGQEVVLSPGSFMSITFRS 120

Query: 121 DFSNEERFTGFDAHYMAVDVDECKEREDEELSCDHYCHNYIGGYYCSCRFGYILHTDNRT 180
           DFSNEERFTGFDAHYMAVDVDECKEREDEELSCDHYCHNYIGGYYCSCRFGYILHTDNRT
Sbjct: 121 DFSNEERFTGFDAHYMAVDVDECKEREDEELSCDHYCHNYIGGYYCSCRFGYILHTDNRT 180

Query: 181 CRVECSDNLFTQRTGVITSPDFPNPYPKSSECLYTIELEEGFMVNLQFEDIFDIEDHPEV 240
           CRVECSDNLFTQRTGVITSPDFPNPYPKSSECLYTIELEEGFMVNLQFEDIFDIEDHPEV
Sbjct: 181 CRVECSDNLFTQRTGVITSPDFPNPYPKSSECLYTIELEEGFMVNLQFEDIFDIEDHPEV 240

Query: 241 PCPYDYIKIKVGPKVLGPFCGEKAPEPISTQSHSVLILFHSDNSGENRGWRLSYRAAGNE 300
           PCPYDYIKIKVGPKVLGPFCGEKAPEPISTQSHSVLILFHSDNSGENRGWRLSYRAAGNE
Sbjct: 241 PCPYDYIKIKVGPKVLGPFCGEKAPEPISTQSHSVLILFHSDNSGENRGWRLSYRAAGNE 300

Query: 301 CPELQPPVHGKIEPSQAKYFFKDQVLVSCDTGYKVLKDNVEMDTFQIECLKDGTWSNKIP 360
           CPELQPPVHGKIEPSQAKYFFKDQVLVSCDTGYKVLKDNVEMDTFQIECLKDGTWSNKIP
Sbjct: 301 CPELQPPVHGKIEPSQAKYFFKDQVLVSCDTGYKVLKDNVEMDTFQIECLKDGTWSNKIP 360

Query: 361 TCKIVDCRAPGELEHGLIT 379
           TCK  +     EL+   +T
Sbjct: 361 TCKKNEIDLESELKSEQVT 379


>gi|21264363 mannan-binding lectin serine protease 2 isoform 1
           precursor [Homo sapiens]
          Length = 686

 Score =  588 bits (1516), Expect = e-168
 Identities = 294/702 (41%), Positives = 423/702 (60%), Gaps = 28/702 (3%)

Query: 1   MRWLLLYYALCFSLSKASAHTVELNNMFGQIQSPGYPDSYPSDSEVTWNITVPDGFRIKL 60
           MR L L   LC S++           +FG++ SPG+P  Y +D E  W +T P G+R++L
Sbjct: 1   MRLLTLLGLLCGSVATPLGPKWP-EPVFGRLASPGFPGEYANDQERRWTLTAPPGYRLRL 59

Query: 61  YFMHFNLESSYLCEYDYVKVETEDQVLATFCGRETTDTEQTPGQEVVLSPGSFMSITFRS 120
           YF HF+LE S+LCEYD+VK+ +  +VLAT CG+E+TDTE+ PG++   S GS + ITFRS
Sbjct: 60  YFTHFDLELSHLCEYDFVKLSSGAKVLATLCGQESTDTERAPGKDTFYSLGSSLDITFRS 119

Query: 121 DFSNEERFTGFDAHYMAVDVDECKEREDEELSCDHYCHNYIGGYYCSCRFGYILHTDNRT 180
           D+SNE+ FTGF+A Y A D+DEC+    E  +CDH+CHN++GG+YCSCR GY+LH + RT
Sbjct: 120 DYSNEKPFTGFEAFYAAEDIDECQVAPGEAPTCDHHCHNHLGGFYCSCRAGYVLHRNKRT 179

Query: 181 CRVECSDNLFTQRTGVITSPDFPNPYPKSSECLYTIELEEGFMVNLQFEDIFDIEDHPEV 240
           C   CS  +FTQR+G ++SP++P PYPK S C Y+I LEEGF V L F + FD+E HPE 
Sbjct: 180 CSALCSGQVFTQRSGELSSPEYPRPYPKLSSCTYSISLEEGFSVILDFVESFDVETHPET 239

Query: 241 PCPYDYIKIKVGPKVLGPFCGEKAPEPISTQSHSVLILFHSDNSGENRGWRLSYRAAGNE 300
            CPYD++KI+   +  GPFCG+  P  I T+S++V I F +D SG++ GW++ Y +    
Sbjct: 240 LCPYDFLKIQTDREEHGPFCGKTLPHRIETKSNTVTITFVTDESGDHTGWKIHYTSTAQP 299

Query: 301 CPELQPPVHGKIEPSQAKYFFKDQVLVSCDTGYKVLKDNVEMDTFQIECLKDGTWSNKIP 360
           CP    P +G + P QAKY  KD   + C+TGY++L+ ++ + +F   C KDG+W   +P
Sbjct: 300 CPYPMAPPNGHVSPVQAKYILKDSFSIFCETGYELLQGHLPLKSFTAVCQKDGSWDRPMP 359

Query: 361 TCKIVDCRAPGELEHGLITFSTRNNLTTYKSEIKYSCQEPYYKMLNNNTGIYTCSAQGVW 420
            C IVDC  P +L  G + + T   +TTYK+ I+YSC+E +Y M   N G Y C A G W
Sbjct: 360 ACSIVDCGPPDDLPSGRVEYITGPGVTTYKAVIQYSCEETFYTM-KVNDGKYVCEADGFW 418

Query: 421 MNKVLGRSLPTCLPVCGLPKFSRKLMARIFNGRPAQKGTTPWIAMLSHLNGQPFCGGSLL 480
            +    +SLP C PVCGL   +R    RI+ G+ A+ G  PW  ++    G     G+LL
Sbjct: 419 TSSKGEKSLPVCEPVCGLS--ARTTGGRIYGGQKAKPGDFPWQVLIL---GGTTAAGALL 473

Query: 481 GSSWIVTAAHCLHQSLDPEDPTLRDSDLLSPSDFKIILGKHWRLRSDENEQHLGVKHTTL 540
             +W++TAAH +++     D +  D   +     K +   + +  S+    H G  H   
Sbjct: 474 YDNWVLTAAHAVYE--QKHDASALD---IRMGTLKRLSPHYTQAWSEAVFIHEGYTHDA- 527

Query: 541 HPQYDPNTFENDVALVELLESPVLNAFVMPICLP----EGPQQEGAMVIVSGWGKQFLQR 596
                   F+ND+AL++L    V+N+ + PICLP    E   +   +   SGWG      
Sbjct: 528 -------GFDNDIALIKLNNKVVINSNITPICLPRKEAESFMRTDDIGTASGWGLTQRGF 580

Query: 597 FPETLMEIEIPIVDHSTCQKAYAP---LKKKVTRDMICAGEKEGGKDACAGDSGGPMVTL 653
               LM ++IPIVDH  C  AY      +  VT +M+CAG + GGKD+C GDSGG +V L
Sbjct: 581 LARNLMYVDIPIVDHQKCTAAYEKPPYPRGSVTANMLCAGLESGGKDSCRGDSGGALVFL 640

Query: 654 NRERGQWYLVGTVSWGD-DCGKKDRYGVYSYIHHNKDWIQRV 694
           + E  +W++ G VSWG  +CG+  +YGVY+ + +   WI+ +
Sbjct: 641 DSETERWFVGGIVSWGSMNCGEAGQYGVYTKVINYIPWIENI 682


>gi|66347875 complement component 1, r subcomponent [Homo sapiens]
          Length = 705

 Score =  491 bits (1263), Expect = e-138
 Identities = 263/715 (36%), Positives = 395/715 (55%), Gaps = 44/715 (6%)

Query: 5   LLYYALCFSLSKASAHTVELNNMFGQIQSPGYPDSYPSDSEVTWNITVPDGFRIKLYFMH 64
           LLY  +     +A         +FG++ SP +P  YP++ E T  ITVP G+R+KL F  
Sbjct: 3   LLYLLVPALFCRAGGSIPIPQKLFGEVTSPLFPKPYPNNFETTTVITVPTGYRVKLVFQQ 62

Query: 65  FNLESSYLCEYDYVKVETEDQVLATFCGRETTDTEQTPGQEVVLSPGSFMSITFRSDFSN 124
           F+LE S  C YDYVK+  + + L  FCG+  +     PG++  +S G+ M +TF +DFSN
Sbjct: 63  FDLEPSEGCFYDYVKISADKKSLGRFCGQLGSPLGNPPGKKEFMSQGNKMLLTFHTDFSN 122

Query: 125 EERFT-----GFDAHYMAVDVDECKER-----EDEELSCDHYCHNYIGGYYCSCRFGYIL 174
           EE  T     GF A+Y AVD+DEC  R     ED +  C H CHNY+GGY+CSCR GY L
Sbjct: 123 EENGTIMFYKGFLAYYQAVDLDECASRSKLGEEDPQPQCQHLCHNYVGGYFCSCRPGYEL 182

Query: 175 HTDNRTCRVECSDNLFTQRTGVITSPDFPNPYPKSSECLYTIELEEGFMVNLQFEDIFDI 234
             D  +C+ ECS  L+T+ +G I+S ++P  YP    C Y+I +E G  ++L+F + FDI
Sbjct: 183 QEDRHSCQAECSSELYTEASGYISSLEYPRSYPPDLRCNYSIRVERGLTLHLKFLEPFDI 242

Query: 235 EDHPEVPCPYDYIKIKVGPKVLGPFCGEKAPEPISTQSHSVLILFHSDNSGENRGWRLSY 294
           +DH +V CPYD ++I    K +G FCG++ P  + T S++V +LF +D SG++RGW+L Y
Sbjct: 243 DDHQQVHCPYDQLQIYANGKNIGEFCGKQRPPDLDTSSNAVDLLFFTDESGDSRGWKLRY 302

Query: 295 RAAGNECPELQPPVHGK---IEPSQAKYFFKDQVLVSCDTGYKVLKDNVEMDTFQIECLK 351
                +CP  QP    +   I+  Q +Y F+D  + +C  GY++++ N  + +F   C  
Sbjct: 303 TTEIIKCP--QPKTLDEFTIIQNLQPQYQFRDYFIATCKQGYQLIEGNQVLHSFTAVCQD 360

Query: 352 DGTWSNKIPTCKIVDCRAPGELEHGLITFSTRNNLTTYKSEIKYSCQEPYYKM------L 405
           DGTW   +P CKI DC  P  L +G   ++T   + TYK+ I+Y C EPYYKM       
Sbjct: 361 DGTWHRAMPRCKIKDCGQPRNLPNGDFRYTTTMGVNTYKARIQYYCHEPYYKMQTRAGSR 420

Query: 406 NNNTGIYTCSAQGVWMNKVLGRSLPTCLPVCGLPKFSRKLMARIFNGRPAQKGTTPWIAM 465
            +  G+YTC+AQG+W N+  G  +P CLPVCG P    +   RI  G+ A+ G  PW  +
Sbjct: 421 ESEQGVYTCTAQGIWKNEQKGEKIPRCLPVCGKPVNPVEQRQRIIGGQKAKMGNFPW-QV 479

Query: 466 LSHLNGQPFCGGSLLGSSWIVTAAHCLHQSLDPEDPTLRDSDLLSPSDFKIILGKHWRLR 525
            ++++G+   GG+LLG  WI+TAAH L+          ++ +  S +   + LG H  + 
Sbjct: 480 FTNIHGRG--GGALLGDRWILTAAHTLYP---------KEHEAQSNASLDVFLG-HTNVE 527

Query: 526 SDENEQHLGVKHTTLHPQY---DPNTFENDVALVELLESPVLNAFVMPICLPEGP--QQE 580
                 +  ++  ++HP Y   +   FE D+AL+EL  S  L   ++PICLP+       
Sbjct: 528 ELMKLGNHPIRRVSVHPDYRQDESYNFEGDIALLELENSVTLGPNLLPICLPDNDTFYDL 587

Query: 581 GAMVIVSGWGKQFLQRFPETLMEIEIPIVDHSTCQKAYAPLKKK--VTRDMICAGEKEGG 638
           G M  VSG+G    ++    L  + +P+ +   C+       +    +++M CAG     
Sbjct: 588 GLMGYVSGFG-VMEEKIAHDLRFVRLPVANPQACENWLRGKNRMDVFSQNMFCAGHPSLK 646

Query: 639 KDACAGDSGGPMVTLNRERGQWYLVGTVSWGDDCGKKDRYGVYSYIHHNKDWIQR 693
           +DAC GDSGG     +    +W   G VSWG  C +   YG Y+ + +  DWI++
Sbjct: 647 QDACQGDSGGVFAVRDPNTDRWVATGIVSWGIGCSR--GYGFYTKVLNYVDWIKK 699


>gi|4502495 complement component 1, s subcomponent precursor [Homo
           sapiens]
          Length = 688

 Score =  443 bits (1140), Expect = e-124
 Identities = 251/707 (35%), Positives = 377/707 (53%), Gaps = 56/707 (7%)

Query: 11  CFSLSKASAHTVELNNMFGQIQSPGYPDSYPSDSEVTWNITVPDGFRIKLYFMHFNLESS 70
           C  L    A       M+G+I SP YP +YPS+ E +W+I VP+G+ I LYF H ++E S
Sbjct: 3   CIVLFSLLAWVYAEPTMYGEILSPNYPQAYPSEVEKSWDIEVPEGYGIHLYFTHLDIELS 62

Query: 71  YLCEYDYVKVETEDQVLATFCGRETTDTEQTPGQEVVLSPGSFMSITFRSDFSNEERFTG 130
             C YD V++ + D      CG+ +++   +P  E    P + + + F+SDFSNEERFTG
Sbjct: 63  ENCAYDSVQIISGDTEEGRLCGQRSSNNPHSPIVEEFQVPYNKLQVIFKSDFSNEERFTG 122

Query: 131 FDAHYMAVDVDECKEREDEELSCDHYCHNYIGGYYCSCRFGYILHTDNRTCRVECSDNLF 190
           F A+Y+A D++EC +  D  + C H+C+N+IGGY+CSC   Y LH D + C V CS ++F
Sbjct: 123 FAAYYVATDINECTDFVD--VPCSHFCNNFIGGYFCSCPPEYFLHDDMKNCGVNCSGDVF 180

Query: 191 TQRTGVITSPDFPNPYPKSSECLYTIELEEGF--MVNLQFEDIFDIEDHPEVPCPYDYIK 248
           T   G I SP++P PYP++S C Y I LE+GF  +V L+ ED FD+E         D + 
Sbjct: 181 TALIGEIASPNYPKPYPENSRCEYQIRLEKGFQVVVTLRRED-FDVEAADSAGNCLDSLV 239

Query: 249 IKVGPKVLGPFCGEKAPEP--ISTQSHSVLILFHSDNSGENRGWRLSYRAAGNECPELQP 306
              G +  GP+CG   P P  I T+S+++ I+F +D +G+ +GW+L Y      CP+   
Sbjct: 240 FVAGDRQFGPYCGHGFPGPLNIETKSNALDIIFQTDLTGQKKGWKLRYHGDPMPCPKEDT 299

Query: 307 PVHGKIEPSQAKYFFKDQVLVSCDTGYKVLKDNVEMDTFQIECLKDGTWSNKIPTCKIVD 366
           P +   EP++AKY F+D V ++C  G++V++  V   +F   C  +G WSN    C+ VD
Sbjct: 300 P-NSVWEPAKAKYVFRDVVQITCLDGFEVVEGRVGATSFYSTCQSNGKWSNSKLKCQPVD 358

Query: 367 CRAPGELEHGLITFSTRNNLTTYKSEIKYSCQEPYYKMLNNNTGIYTCSAQGVWMNKVLG 426
           C  P  +E+G +        T + S I+Y+C+EPYY M N   G Y C+  G W+N+VLG
Sbjct: 359 CGIPESIENGKV---EDPESTLFGSVIRYTCEEPYYYMENGGGGEYHCAGNGSWVNEVLG 415

Query: 427 RSLPTCLPVCGLPKFSRKLMARIFNGRPAQKGTTPWIAMLSHLNGQPFCGGSLLGSSWIV 486
             LP C+PVCG+P+   +   RI  G  A     PW     +    P+ GG+L+   W++
Sbjct: 416 PELPKCVPVCGVPREPFEEKQRIIGGSDADIKNFPWQVFFDN----PWAGGALINEYWVL 471

Query: 487 TAAHCLHQSLDP---------EDPTLRDSDLLSPSDFKIILGKHWRLRSDENEQHLGVKH 537
           TAAH +  + +P         +   L  S +L+P    + +   W+L             
Sbjct: 472 TAAHVVEGNREPTMYVGSTSVQTSRLAKSKMLTPE--HVFIHPGWKL------------- 516

Query: 538 TTLHPQYDPNTFENDVALVELLESPVLNAFVMPICLP----EGPQQEGAMVIVSGWGKQF 593
             L        F+ND+ALV L +   +   V PICLP    +    +G + ++SGWG+  
Sbjct: 517 --LEVPEGRTNFDNDIALVRLKDPVKMGPTVSPICLPGTSSDYNLMDGDLGLISGWGRTE 574

Query: 594 LQRFPETLMEIEIPIVDHSTC-----QKAYAPLKKKV-TRDMICAGEKEGGKDACAGDSG 647
            +     L    +P+     C     +K  A  +  V T +MICAG  E G D+C GDSG
Sbjct: 575 KRDRAVRLKAARLPVAPLRKCKEVKVEKPTADAEAYVFTPNMICAG-GEKGMDSCKGDSG 633

Query: 648 GPMVTLN-RERGQWYLVGTVSWGDDCGKKDRYGVYSYIHHNKDWIQR 693
           G     +  ++ ++Y  G VSWG  CG    YG+Y+ + +  DWI +
Sbjct: 634 GAFAVQDPNDKTKFYAAGLVSWGPQCG---TYGLYTRVKNYVDWIMK 677


>gi|41393602 complement component 1, s subcomponent precursor [Homo
           sapiens]
          Length = 688

 Score =  443 bits (1140), Expect = e-124
 Identities = 251/707 (35%), Positives = 377/707 (53%), Gaps = 56/707 (7%)

Query: 11  CFSLSKASAHTVELNNMFGQIQSPGYPDSYPSDSEVTWNITVPDGFRIKLYFMHFNLESS 70
           C  L    A       M+G+I SP YP +YPS+ E +W+I VP+G+ I LYF H ++E S
Sbjct: 3   CIVLFSLLAWVYAEPTMYGEILSPNYPQAYPSEVEKSWDIEVPEGYGIHLYFTHLDIELS 62

Query: 71  YLCEYDYVKVETEDQVLATFCGRETTDTEQTPGQEVVLSPGSFMSITFRSDFSNEERFTG 130
             C YD V++ + D      CG+ +++   +P  E    P + + + F+SDFSNEERFTG
Sbjct: 63  ENCAYDSVQIISGDTEEGRLCGQRSSNNPHSPIVEEFQVPYNKLQVIFKSDFSNEERFTG 122

Query: 131 FDAHYMAVDVDECKEREDEELSCDHYCHNYIGGYYCSCRFGYILHTDNRTCRVECSDNLF 190
           F A+Y+A D++EC +  D  + C H+C+N+IGGY+CSC   Y LH D + C V CS ++F
Sbjct: 123 FAAYYVATDINECTDFVD--VPCSHFCNNFIGGYFCSCPPEYFLHDDMKNCGVNCSGDVF 180

Query: 191 TQRTGVITSPDFPNPYPKSSECLYTIELEEGF--MVNLQFEDIFDIEDHPEVPCPYDYIK 248
           T   G I SP++P PYP++S C Y I LE+GF  +V L+ ED FD+E         D + 
Sbjct: 181 TALIGEIASPNYPKPYPENSRCEYQIRLEKGFQVVVTLRRED-FDVEAADSAGNCLDSLV 239

Query: 249 IKVGPKVLGPFCGEKAPEP--ISTQSHSVLILFHSDNSGENRGWRLSYRAAGNECPELQP 306
              G +  GP+CG   P P  I T+S+++ I+F +D +G+ +GW+L Y      CP+   
Sbjct: 240 FVAGDRQFGPYCGHGFPGPLNIETKSNALDIIFQTDLTGQKKGWKLRYHGDPMPCPKEDT 299

Query: 307 PVHGKIEPSQAKYFFKDQVLVSCDTGYKVLKDNVEMDTFQIECLKDGTWSNKIPTCKIVD 366
           P +   EP++AKY F+D V ++C  G++V++  V   +F   C  +G WSN    C+ VD
Sbjct: 300 P-NSVWEPAKAKYVFRDVVQITCLDGFEVVEGRVGATSFYSTCQSNGKWSNSKLKCQPVD 358

Query: 367 CRAPGELEHGLITFSTRNNLTTYKSEIKYSCQEPYYKMLNNNTGIYTCSAQGVWMNKVLG 426
           C  P  +E+G +        T + S I+Y+C+EPYY M N   G Y C+  G W+N+VLG
Sbjct: 359 CGIPESIENGKV---EDPESTLFGSVIRYTCEEPYYYMENGGGGEYHCAGNGSWVNEVLG 415

Query: 427 RSLPTCLPVCGLPKFSRKLMARIFNGRPAQKGTTPWIAMLSHLNGQPFCGGSLLGSSWIV 486
             LP C+PVCG+P+   +   RI  G  A     PW     +    P+ GG+L+   W++
Sbjct: 416 PELPKCVPVCGVPREPFEEKQRIIGGSDADIKNFPWQVFFDN----PWAGGALINEYWVL 471

Query: 487 TAAHCLHQSLDP---------EDPTLRDSDLLSPSDFKIILGKHWRLRSDENEQHLGVKH 537
           TAAH +  + +P         +   L  S +L+P    + +   W+L             
Sbjct: 472 TAAHVVEGNREPTMYVGSTSVQTSRLAKSKMLTPE--HVFIHPGWKL------------- 516

Query: 538 TTLHPQYDPNTFENDVALVELLESPVLNAFVMPICLP----EGPQQEGAMVIVSGWGKQF 593
             L        F+ND+ALV L +   +   V PICLP    +    +G + ++SGWG+  
Sbjct: 517 --LEVPEGRTNFDNDIALVRLKDPVKMGPTVSPICLPGTSSDYNLMDGDLGLISGWGRTE 574

Query: 594 LQRFPETLMEIEIPIVDHSTC-----QKAYAPLKKKV-TRDMICAGEKEGGKDACAGDSG 647
            +     L    +P+     C     +K  A  +  V T +MICAG  E G D+C GDSG
Sbjct: 575 KRDRAVRLKAARLPVAPLRKCKEVKVEKPTADAEAYVFTPNMICAG-GEKGMDSCKGDSG 633

Query: 648 GPMVTLN-RERGQWYLVGTVSWGDDCGKKDRYGVYSYIHHNKDWIQR 693
           G     +  ++ ++Y  G VSWG  CG    YG+Y+ + +  DWI +
Sbjct: 634 GAFAVQDPNDKTKFYAAGLVSWGPQCG---TYGLYTRVKNYVDWIMK 677


>gi|21264361 mannan-binding lectin serine protease 2 isoform 2
           precursor [Homo sapiens]
          Length = 185

 Score =  207 bits (526), Expect = 3e-53
 Identities = 93/181 (51%), Positives = 128/181 (70%), Gaps = 1/181 (0%)

Query: 1   MRWLLLYYALCFSLSKASAHTVELNNMFGQIQSPGYPDSYPSDSEVTWNITVPDGFRIKL 60
           MR L L   LC S++           +FG++ SPG+P  Y +D E  W +T P G+R++L
Sbjct: 1   MRLLTLLGLLCGSVATPLGPKWP-EPVFGRLASPGFPGEYANDQERRWTLTAPPGYRLRL 59

Query: 61  YFMHFNLESSYLCEYDYVKVETEDQVLATFCGRETTDTEQTPGQEVVLSPGSFMSITFRS 120
           YF HF+LE S+LCEYD+VK+ +  +VLAT CG+E+TDTE+ PG++   S GS + ITFRS
Sbjct: 60  YFTHFDLELSHLCEYDFVKLSSGAKVLATLCGQESTDTERAPGKDTFYSLGSSLDITFRS 119

Query: 121 DFSNEERFTGFDAHYMAVDVDECKEREDEELSCDHYCHNYIGGYYCSCRFGYILHTDNRT 180
           D+SNE+ FTGF+A Y A D+DEC+    E  +CDH+CHN++GG+YCSCR GY+LH + RT
Sbjct: 120 DYSNEKPFTGFEAFYAAEDIDECQVAPGEAPTCDHHCHNHLGGFYCSCRAGYVLHRNKRT 179

Query: 181 C 181
           C
Sbjct: 180 C 180



 Score = 49.7 bits (117), Expect = 9e-06
 Identities = 40/119 (33%), Positives = 55/119 (46%), Gaps = 16/119 (13%)

Query: 195 GVITSPDFPNPYPKSSECLYTIELEEGFMVNLQFEDIFDIE-DHPEVPCPYDYIKIKVGP 253
           G + SP FP  Y    E  +T+    G+ + L F   FD+E  H    C YD++K+  G 
Sbjct: 28  GRLASPGFPGEYANDQERRWTLTAPPGYRLRLYFTH-FDLELSHL---CEYDFVKLSSGA 83

Query: 254 KVLGPFCG------EKAP--EPISTQSHSVLILFHSDNSGEN--RGWRLSYRAAG-NEC 301
           KVL   CG      E+AP  +   +   S+ I F SD S E    G+   Y A   +EC
Sbjct: 84  KVLATLCGQESTDTERAPGKDTFYSLGSSLDITFRSDYSNEKPFTGFEAFYAAEDIDEC 142


>gi|11415040 matriptase [Homo sapiens]
          Length = 855

 Score =  186 bits (473), Expect = 5e-47
 Identities = 187/711 (26%), Positives = 294/711 (41%), Gaps = 131/711 (18%)

Query: 33  SPGYPDS-YPSDSEVTWNITVPDGFRIKLYFMHFNLESSYLCEYDYVKVET-----EDQV 86
           +PG+PDS YP+ +   W +       + L F  F+L S      D V V       E   
Sbjct: 230 TPGFPDSPYPAHARCQWALRGDADSVLSLTFRSFDLASCDERGSDLVTVYNTLSPMEPHA 289

Query: 87  LATFCGRETTDTEQT--PGQEVVLSPGSFMSITFRSDFSNEERFTGFDAHYMAVDVDECK 144
           L   CG        T    Q V+L       IT  ++   E R  GF+A +  +      
Sbjct: 290 LVQLCGTYPPSYNLTFHSSQNVLL-------ITLITN--TERRHPGFEATFFQLP----- 335

Query: 145 EREDEELSCDHYCHNYIGGYYCSCRFGYILHTDNRTCRVECSDNLFTQRTGVITSPDFPN 204
                                                R+        +  G   SP +P 
Sbjct: 336 -------------------------------------RMSSCGGRLRKAQGTFNSPYYPG 358

Query: 205 PYPKSSECLYTIELEEGFMVNLQFEDIFDIEDHPEVP---CPYDYIKIKVGPKVLGPFCG 261
            YP + +C + IE+     V ++F+  + +E  P VP   CP DY++I  G K    +CG
Sbjct: 359 HYPPNIDCTWNIEVPNNQHVKVRFKFFYLLE--PGVPAGTCPKDYVEIN-GEK----YCG 411

Query: 262 EKAPEPISTQSHSVLILFHSDNSGENRGWRLSYRA--AGNECPELQPPVHGKIEPSQAKY 319
           E++   +++ S+ + + FHSD S  + G+   Y +  + + CP       G+    + + 
Sbjct: 412 ERSQFVVTSNSNKITVRFHSDQSYTDTGFLAEYLSYDSSDPCPGQFTCRTGRCIRKELRC 471

Query: 320 F-------FKDQVLVSCDTGYKVLKDNVEMDTFQIECLKDGTWSNKIPTCKIVDCRAPGE 372
                     D++  SCD G++    N        +  K   W      C  V+      
Sbjct: 472 DGWADCTDHSDELNCSCDAGHQFTCKN--------KFCKPLFW-----VCDSVNDCGDNS 518

Query: 373 LEHGLI----TFSTRNNLTTYKSEI---KYSCQEPYYKMLNNNTGIYTCSAQGV-WMNKV 424
            E G      TF   N     KS+    K  C +   +       + TC+      +N +
Sbjct: 519 DEQGCSCPAQTFRCSNGKCLSKSQQCNGKDDCGDGSDEASCPKVNVVTCTKHTYRCLNGL 578

Query: 425 -LGRSLPTCLPV-------------CGLPKFSRKLMARIFNGRPAQKGTTPWIAMLSHLN 470
            L +  P C                CGL  F+R+  AR+  G  A +G  PW   L  L 
Sbjct: 579 CLSKGNPECDGKEDCSDGSDEKDCDCGLRSFTRQ--ARVVGGTDADEGEWPWQVSLHALG 636

Query: 471 GQPFCGGSLLGSSWIVTAAHCLHQSLDPEDPTLRDSDLLSPSDFKIILGKH-WRLRSDEN 529
               CG SL+  +W+V+AAHC       +D   R SD   P+ +   LG H    RS   
Sbjct: 637 QGHICGASLISPNWLVSAAHCY-----IDDRGFRYSD---PTQWTAFLGLHDQSQRSAPG 688

Query: 530 EQHLGVKHTTLHPQYDPNTFENDVALVELLESPVLNAFVMPICLPEGPQ--QEGAMVIVS 587
            Q   +K    HP ++  TF+ D+AL+EL +    ++ V PICLP+       G  + V+
Sbjct: 689 VQERRLKRIISHPFFNDFTFDYDIALLELEKPAEYSSMVRPICLPDASHVFPAGKAIWVT 748

Query: 588 GWG-KQFLQRFPETLMEIEIPIVDHSTCQKAYAPLKKKVTRDMICAGEKEGGKDACAGDS 646
           GWG  Q+       L + EI +++ +TC+     L +++T  M+C G   GG D+C GDS
Sbjct: 749 GWGHTQYGGTGALILQKGEIRVINQTTCENL---LPQQITPRMMCVGFLSGGVDSCQGDS 805

Query: 647 GGPMVTLNRERGQWYLVGTVSWGDDCGKKDRYGVYSYIHHNKDWIQRVTGV 697
           GGP+ ++  + G+ +  G VSWGD C ++++ GVY+ +   +DWI+  TGV
Sbjct: 806 GGPLSSVEAD-GRIFQAGVVSWGDGCAQRNKPGVYTRLPLFRDWIKENTGV 855



 Score = 68.2 bits (165), Expect = 3e-11
 Identities = 58/206 (28%), Positives = 88/206 (42%), Gaps = 39/206 (18%)

Query: 7   YYALCFSLSKASAHTVELNNMFGQIQSPGYPDSYPSDSEVTWNITVPDGFRIKLYFMHFN 66
           + A  F L + S+    L    G   SP YP  YP + + TWNI VP+   +K+ F  F 
Sbjct: 327 FEATFFQLPRMSSCGGRLRKAQGTFNSPYYPGHYPPNIDCTWNIEVPNNQHVKVRFKFFY 386

Query: 67  L----ESSYLCEYDYVKVETEDQVLATFCGRETTDTEQTPGQEVVLSPGSFMSITFRSDF 122
           L      +  C  DYV++  E      +CG  +        Q VV S  + +++ F SD 
Sbjct: 387 LLEPGVPAGTCPKDYVEINGE-----KYCGERS--------QFVVTSNSNKITVRFHSDQ 433

Query: 123 SNEERFTGFDAHYMAVDVDE-------CKERE--DEELSCDHY--CHNYIGGYYCSCRFG 171
           S  +  TGF A Y++ D  +       C+      +EL CD +  C ++     CSC  G
Sbjct: 434 SYTD--TGFLAEYLSYDSSDPCPGQFTCRTGRCIRKELRCDGWADCTDHSDELNCSCDAG 491

Query: 172 YILHTDNRTCRV---------ECSDN 188
           +     N+ C+          +C DN
Sbjct: 492 HQFTCKNKFCKPLFWVCDSVNDCGDN 517


>gi|5453579 bone morphogenetic protein 1 isoform 3 precursor [Homo
           sapiens]
          Length = 986

 Score =  172 bits (436), Expect = 9e-43
 Identities = 96/279 (34%), Positives = 146/279 (52%), Gaps = 25/279 (8%)

Query: 24  LNNMFGQIQSPGYPDSYPSDSEVTWNITVPDGFRIKLYFMHFNLESSYLCEYDYVKVET- 82
           L  + G I SPG+P  YP +    W +  P  +RI L F  F  E + +C+YD+V+V + 
Sbjct: 595 LTKLNGSITSPGWPKEYPPNKNCIWQLVAPTQYRISLQFDFFETEGNDVCKYDFVEVRSG 654

Query: 83  ---EDQVLATFCGRETTDTEQTPGQEVVLSPGSFMSITFRSDFSNEERFTGFDAHYMAVD 139
              + ++   FCG E          EV+ S  + M + F+SD +  ++  GF AH+ + D
Sbjct: 655 LTADSKLHGKFCGSEKP--------EVITSQYNNMRVEFKSDNTVSKK--GFKAHFFS-D 703

Query: 140 VDECKEREDEELSCDHYCHNYIGGYYCSCRFGYILHTDNRTCRVECSDNLFTQRTGVITS 199
            DEC +   +   C   C N  G Y C CR G++LH +   C+    D+  T  +G ITS
Sbjct: 704 KDECSK---DNGGCQQDCVNTFGSYECQCRSGFVLHDNKHDCKEAGCDHKVTSTSGTITS 760

Query: 200 PDFPNPYPKSSECLYTIELEEGFMVNLQFEDIFDIEDHPEVPCPYDYIKIKVG----PKV 255
           P++P+ YP   EC + I    G  V L F ++ DIE  PE  C YD++++  G      V
Sbjct: 761 PNWPDKYPSKKECTWAISSTPGHRVKLTFMEM-DIESQPE--CAYDHLEVFDGRDAKAPV 817

Query: 256 LGPFCGEKAPEPISTQSHSVLILFHSDNSGENRGWRLSY 294
           LG FCG K PEP+      + + F+SDNS + +G++ S+
Sbjct: 818 LGRFCGSKKPEPVLATGSRMFLRFYSDNSVQRKGFQASH 856



 Score =  151 bits (381), Expect = 2e-36
 Identities = 90/282 (31%), Positives = 139/282 (49%), Gaps = 25/282 (8%)

Query: 28  FGQIQSPGYPDSYPSDSEVTWNITVPDGFRIKLYFMHFNLESSYLCEYDYVKV----ETE 83
           +G IQSP YPD Y       W I V +GF + L F  F +E    C YDY++V       
Sbjct: 443 YGHIQSPNYPDDYRPSKVCIWRIQVSEGFHVGLTFQSFEIERHDSCAYDYLEVRDGHSES 502

Query: 84  DQVLATFCGRETTDTEQTPGQEVVLSPGSFMSITFRSDFSNEERFTGFDAHYMAVDVDEC 143
             ++  +CG E  D         + S  S + + F SD S  +   GF  ++   +VDEC
Sbjct: 503 STLIGRYCGYEKPDD--------IKSTSSRLWLKFVSDGSINK--AGFAVNFFK-EVDEC 551

Query: 144 KEREDEELSCDHYCHNYIGGYYCSCRFGYILHTDNRTCRVECSDNLFTQRTGVITSPDFP 203
                    C+  C N +G Y CSC  GY L  D R C   C     T+  G ITSP +P
Sbjct: 552 S--RPNRGGCEQRCLNTLGSYKCSCDPGYELAPDKRRCEAACG-GFLTKLNGSITSPGWP 608

Query: 204 NPYPKSSECLYTIELEEGFMVNLQFEDIFDIEDHPEVPCPYDYIKIKVG----PKVLGPF 259
             YP +  C++ +     + ++LQF D F+ E +    C YD+++++ G     K+ G F
Sbjct: 609 KEYPPNKNCIWQLVAPTQYRISLQF-DFFETEGND--VCKYDFVEVRSGLTADSKLHGKF 665

Query: 260 CGEKAPEPISTQSHSVLILFHSDNSGENRGWRLSYRAAGNEC 301
           CG + PE I++Q +++ + F SDN+   +G++  + +  +EC
Sbjct: 666 CGSEKPEVITSQYNNMRVEFKSDNTVSKKGFKAHFFSDKDEC 707



 Score =  107 bits (268), Expect = 3e-23
 Identities = 85/276 (30%), Positives = 123/276 (44%), Gaps = 68/276 (24%)

Query: 29  GQIQSPGYPDSYPSDSEVTWNITVPDGFRIKLYFMHFNLESSYLCEYDYVKV----ETED 84
           G I SP +PD YPS  E TW I+   G R+KL FM  ++ES   C YD+++V    + + 
Sbjct: 756 GTITSPNWPDKYPSKKECTWAISSTPGHRVKLTFMEMDIESQPECAYDHLEVFDGRDAKA 815

Query: 85  QVLATFCGRETTDTEQTPGQEVVLSPGSFMSITFRSDFSNEERFTGFDAHYMAVDVDECK 144
            VL  FCG +          E VL+ GS M + F SD S + +  GF A +      EC 
Sbjct: 816 PVLGRFCGSKKP--------EPVLATGSRMFLRFYSDNSVQRK--GFQASHAT----ECG 861

Query: 145 EREDEELSC-DHYCHNYIGGYYCSCRFGYILHTDNRTCRVECSDNLFTQRTGVITSPDFP 203
            +   ++   D Y H   G                                         
Sbjct: 862 GQVRADVKTKDLYSHAQFGD---------------------------------------- 881

Query: 204 NPYPKSSECLYTIELEEGFMVNLQFEDIFDIEDHPEVPCPYDYIKIKVG-----PKVLGP 258
           N YP   +C + I  EEG+ V L F+  F++E+  E  C YDY+++  G     P+ LG 
Sbjct: 882 NNYPGGVDCEWVIVAEEGYGVELVFQT-FEVEE--ETDCGYDYMELFDGYDSTAPR-LGR 937

Query: 259 FCGEKAPEPISTQSHSVLILFHSDNSGENRGWRLSY 294
           +CG   PE + +   SVL+ FHSD++   +G+ L Y
Sbjct: 938 YCGSGPPEEVYSAGDSVLVKFHSDDTITKKGFHLRY 973



 Score = 95.9 bits (237), Expect = 1e-19
 Identities = 90/333 (27%), Positives = 137/333 (41%), Gaps = 73/333 (21%)

Query: 14  LSKASAHTVELNNMFGQIQSPGYPDSYPSDSEVTWNITVPDGFRIKLYFMHFNLESSYLC 73
           L K  A    L +  G   SP YP+ Y +     W I+V  G +I L F   +L  S LC
Sbjct: 316 LYKCPACGETLQDSTGNFSSPEYPNGYSAHMHCVWRISVTPGEKIILNFTSLDLYRSRLC 375

Query: 74  EYDYVKVE----TEDQVLATFCGRETTDTEQTPGQEVVLSPGSFMSITFRSDFSNEERFT 129
            YDYV+V      +  +   FCG +          E ++S  S + + FRS  S+     
Sbjct: 376 WYDYVEVRDGFWRKAPLRGRFCGSKL--------PEPIVSTDSRLWVEFRS--SSNWVGK 425

Query: 130 GFDAHYMAVDVDECKEREDEELSCDHYCHNYIGGYYCSCRFGYILHTDNRTCRVECSDNL 189
           GF A Y A+   + K+        D+                                  
Sbjct: 426 GFFAVYEAICGGDVKK--------DY---------------------------------- 443

Query: 190 FTQRTGVITSPDFPNPYPKSSECLYTIELEEGFMVNLQFEDIFDIEDHPEVPCPYDYIKI 249
                G I SP++P+ Y  S  C++ I++ EGF V L F+  F+IE H    C YDY+++
Sbjct: 444 -----GHIQSPNYPDDYRPSKVCIWRIQVSEGFHVGLTFQS-FEIERHDS--CAYDYLEV 495

Query: 250 KVG----PKVLGPFCGEKAPEPISTQSHSVLILFHSDNSGENRGWRLSYRAAGNECPELQ 305
           + G      ++G +CG + P+ I + S  + + F SD S    G+ +++    +EC    
Sbjct: 496 RDGHSESSTLIGRYCGYEKPDDIKSTSSRLWLKFVSDGSINKAGFAVNFFKEVDECSR-- 553

Query: 306 PPVHGKIEPSQAKYFFKDQVLVSCDTGYKVLKD 338
            P  G  E  Q           SCD GY++  D
Sbjct: 554 -PNRGGCE--QRCLNTLGSYKCSCDPGYELAPD 583


>gi|6912724 tolloid-like 2 [Homo sapiens]
          Length = 1015

 Score =  170 bits (431), Expect = 4e-42
 Identities = 100/287 (34%), Positives = 152/287 (52%), Gaps = 25/287 (8%)

Query: 23  ELNNMFGQIQSPGYPDSYPSDSEVTWNITVPDGFRIKLYFMHFNLESSYLCEYDYVKVE- 81
           ++N   GQIQSP YPD Y    E  W ITV +GF + L F  F +E    C YDY++V  
Sbjct: 467 DMNKDAGQIQSPNYPDDYRPSKECVWRITVSEGFHVGLTFQAFEIERHDSCAYDYLEVRD 526

Query: 82  ---TEDQVLATFCGRETTDTEQTPGQEVVLSPGSFMSITFRSDFSNEERFTGFDAHYMAV 138
               E  ++  FCG E          E V S  + + + F SD S  +   GF A++   
Sbjct: 527 GPTEESALIGHFCGYEK--------PEDVKSSSNRLWMKFVSDGSINK--AGFAANFFK- 575

Query: 139 DVDECKEREDEELSCDHYCHNYIGGYYCSCRFGYILHTDNRTCRVECSDNLFTQRTGVIT 198
           +VDEC     +   C+H C N +G Y C+C  GY L  D + C V C     T+  G IT
Sbjct: 576 EVDECS--WPDHGGCEHRCVNTLGSYKCACDPGYELAADKKMCEVACG-GFITKLNGTIT 632

Query: 199 SPDFPNPYPKSSECLYTIELEEGFMVNLQFEDIFDIEDHPEVPCPYDYIKIKVG----PK 254
           SP +P  YP +  C++ +     + ++LQFE +F++E +    C YD+++++ G     K
Sbjct: 633 SPGWPKEYPTNKNCVWQVVAPAQYRISLQFE-VFELEGND--VCKYDFVEVRSGLSPDAK 689

Query: 255 VLGPFCGEKAPEPISTQSHSVLILFHSDNSGENRGWRLSYRAAGNEC 301
           + G FCG + PE I++QS+++ + F SDN+   RG+R  + +  +EC
Sbjct: 690 LHGRFCGSETPEVITSQSNNMRVEFKSDNTVSKRGFRAHFFSDKDEC 736



 Score =  168 bits (425), Expect = 2e-41
 Identities = 94/276 (34%), Positives = 144/276 (52%), Gaps = 25/276 (9%)

Query: 24  LNNMFGQIQSPGYPDSYPSDSEVTWNITVPDGFRIKLYFMHFNLESSYLCEYDYVKVET- 82
           +  + G I SPG+P  YP++    W +  P  +RI L F  F LE + +C+YD+V+V + 
Sbjct: 624 ITKLNGTITSPGWPKEYPTNKNCVWQVVAPAQYRISLQFEVFELEGNDVCKYDFVEVRSG 683

Query: 83  ---EDQVLATFCGRETTDTEQTPGQEVVLSPGSFMSITFRSDFSNEERFTGFDAHYMAVD 139
              + ++   FCG ET         EV+ S  + M + F+SD +  +R  GF AH+ + D
Sbjct: 684 LSPDAKLHGRFCGSETP--------EVITSQSNNMRVEFKSDNTVSKR--GFRAHFFS-D 732

Query: 140 VDECKEREDEELSCDHYCHNYIGGYYCSCRFGYILHTDNRTCRVECSDNLFTQRTGVITS 199
            DEC +   +   C H C N  G Y C CR GY LH +   C+     +  +   G + S
Sbjct: 733 KDECAK---DNGGCQHECVNTFGSYLCRCRNGYWLHENGHDCKEAGCAHKISSVEGTLAS 789

Query: 200 PDFPNPYPKSSECLYTIELEEGFMVNLQFEDIFDIEDHPEVPCPYDYIKIKVGP----KV 255
           P++P+ YP   EC + I    G  V L F + F+IE H E  C YD++++  GP     +
Sbjct: 790 PNWPDKYPSRRECTWNISSTAGHRVKLTFNE-FEIEQHQE--CAYDHLEMYDGPDSLAPI 846

Query: 256 LGPFCGEKAPEPISTQSHSVLILFHSDNSGENRGWR 291
           LG FCG K P+P      S+ + F+SD S + +G++
Sbjct: 847 LGRFCGSKKPDPTVASGSSMFLRFYSDASVQRKGFQ 882



 Score =  110 bits (276), Expect = 3e-24
 Identities = 96/333 (28%), Positives = 143/333 (42%), Gaps = 73/333 (21%)

Query: 14  LSKASAHTVELNNMFGQIQSPGYPDSYPSDSEVTWNITVPDGFRIKLYFMHFNLESSYLC 73
           L K  A    L +  G   +PG+P+ YPS S   W I+V  G +I L F   +L  S LC
Sbjct: 345 LYKCPACGETLQDTTGNFSAPGFPNGYPSYSHCVWRISVTPGEKIVLNFTSMDLFKSRLC 404

Query: 74  EYDYVKVE----TEDQVLATFCGRETTDTEQTPGQEVVLSPGSFMSITFRSDFSNEERFT 129
            YDYV+V      +  +L  FCG      ++ P  E ++S  S + + FRS  S+     
Sbjct: 405 WYDYVEVRDGYWRKAPLLGRFCG------DKIP--EPLVSTDSRLWVEFRS--SSNILGK 454

Query: 130 GFDAHYMAVDVDECKEREDEELSCDHYCHNYIGGYYCSCRFGYILHTDNRTCRVECSDNL 189
           GF A Y A                                          TC  + + + 
Sbjct: 455 GFFAAYEA------------------------------------------TCGGDMNKD- 471

Query: 190 FTQRTGVITSPDFPNPYPKSSECLYTIELEEGFMVNLQFEDIFDIEDHPEVPCPYDYIKI 249
                G I SP++P+ Y  S EC++ I + EGF V L F+  F+IE H    C YDY+++
Sbjct: 472 ----AGQIQSPNYPDDYRPSKECVWRITVSEGFHVGLTFQ-AFEIERHDS--CAYDYLEV 524

Query: 250 KVGP----KVLGPFCGEKAPEPISTQSHSVLILFHSDNSGENRGWRLSYRAAGNECPELQ 305
           + GP     ++G FCG + PE + + S+ + + F SD S    G+  ++    +EC    
Sbjct: 525 RDGPTEESALIGHFCGYEKPEDVKSSSNRLWMKFVSDGSINKAGFAANFFKEVDEC---S 581

Query: 306 PPVHGKIEPSQAKYFFKDQVLVSCDTGYKVLKD 338
            P HG  E              +CD GY++  D
Sbjct: 582 WPDHGGCEHRCVNTL--GSYKCACDPGYELAAD 612



 Score = 95.1 bits (235), Expect = 2e-19
 Identities = 76/281 (27%), Positives = 120/281 (42%), Gaps = 66/281 (23%)

Query: 23   ELNNMFGQIQSPGYPDSYPSDSEVTWNITVPDGFRIKLYFMHFNLESSYLCEYDYVKV-- 80
            +++++ G + SP +PD YPS  E TWNI+   G R+KL F  F +E    C YD++++  
Sbjct: 779  KISSVEGTLASPNWPDKYPSRRECTWNISSTAGHRVKLTFNEFEIEQHQECAYDHLEMYD 838

Query: 81   --ETEDQVLATFCGRETTDTEQTPGQEVVLSPGSFMSITFRSDFSNEERFTGFDAHYMAV 138
              ++   +L  FCG +  D          ++ GS M + F SD S + +       + AV
Sbjct: 839  GPDSLAPILGRFCGSKKPDP--------TVASGSSMFLRFYSDASVQRK------GFQAV 884

Query: 139  DVDECKEREDEELSCDHYCHNYIGGYYCSCRFGYILHTDNRTCRVECSDNLFTQRTGVIT 198
               EC  R   E+             Y   +FG                           
Sbjct: 885  HSTECGGRLKAEVQTKE--------LYSHAQFG--------------------------- 909

Query: 199  SPDFPNPYPKSSECLYTIELEEGFMVNLQFEDIFDIEDHPEVPCPYDYIKIKVG-----P 253
                 N YP  + C + I  E+G+ V L F   F++E+  E  C YDY++   G     P
Sbjct: 910  ----DNNYPSEARCDWVIVAEDGYGVELTFR-TFEVEE--EADCGYDYMEAYDGYDSSAP 962

Query: 254  KVLGPFCGEKAPEPISTQSHSVLILFHSDNSGENRGWRLSY 294
            + LG FCG    E I +   S++I F +D++   +G+   Y
Sbjct: 963  R-LGRFCGSGPLEEIYSAGDSLMIRFRTDDTINKKGFHARY 1002



 Score = 48.9 bits (115), Expect = 2e-05
 Identities = 38/131 (29%), Positives = 58/131 (44%), Gaps = 23/131 (17%)

Query: 11   CFSLSKASAHTVELNN--MFGQIQSPGYPDSYPSDSEVTWNITVPDGFRIKLYFMHFNLE 68
            C    KA   T EL +   FG        ++YPS++   W I   DG+ ++L F  F +E
Sbjct: 889  CGGRLKAEVQTKELYSHAQFGD-------NNYPSEARCDWVIVAEDGYGVELTFRTFEVE 941

Query: 69   SSYLCEYDYVKV----ETEDQVLATFCGRETTDTEQTPGQEVVLSPGSFMSITFRSDFSN 124
                C YDY++     ++    L  FCG        +   E + S G  + I FR+D + 
Sbjct: 942  EEADCGYDYMEAYDGYDSSAPRLGRFCG--------SGPLEEIYSAGDSLMIRFRTDDTI 993

Query: 125  EERFTGFDAHY 135
             ++  GF A Y
Sbjct: 994  NKK--GFHARY 1002


>gi|22547221 tolloid-like 1 [Homo sapiens]
          Length = 1013

 Score =  167 bits (424), Expect = 2e-41
 Identities = 92/280 (32%), Positives = 149/280 (53%), Gaps = 27/280 (9%)

Query: 24  LNNMFGQIQSPGYPDSYPSDSEVTWNITVPDGFRIKLYFMHFNLESSYLCEYDYVKV--- 80
           L  + G I +PG+P  YP +    W +  P  +RI + F  F LE + +C+YDYV++   
Sbjct: 622 LTKLNGTITTPGWPKEYPPNKNCVWQVVAPTQYRISVKFEFFELEGNEVCKYDYVEIWSG 681

Query: 81  -ETEDQVLATFCGRETTDTEQTPGQEVVLSPGSFMSITFRSDFSNEERFTGFDAHYMAVD 139
             +E ++   FCG E          EV+ S  + M I F+SD +  ++  GF AH+ + D
Sbjct: 682 LSSESKLHGKFCGAEVP--------EVITSQFNNMRIEFKSDNTVSKK--GFKAHFFS-D 730

Query: 140 VDECKEREDEELSCDHYCHNYIGGYYCSCRFGYILHTDNRTCR-VECSDNLFTQRTGVIT 198
            DEC +   +   C H C N +G Y C CR G++LH +   C+  EC   + +  +G+IT
Sbjct: 731 KDECSK---DNGGCQHECVNTMGSYMCQCRNGFVLHDNKHDCKEAECEQKIHSP-SGLIT 786

Query: 199 SPDFPNPYPKSSECLYTIELEEGFMVNLQFEDIFDIEDHPEVPCPYDYIKIKVG----PK 254
           SP++P+ YP   EC + I    G  + L F + F+IE H E  C YD++++  G      
Sbjct: 787 SPNWPDKYPSRKECTWEISATPGHRIKLAFSE-FEIEQHQE--CAYDHLEVFDGETEKSP 843

Query: 255 VLGPFCGEKAPEPISTQSHSVLILFHSDNSGENRGWRLSY 294
           +LG  CG K P+P+    + + + F SD S + +G++ ++
Sbjct: 844 ILGRLCGNKIPDPLVATGNKMFVRFVSDASVQRKGFQATH 883



 Score =  153 bits (386), Expect = 6e-37
 Identities = 106/359 (29%), Positives = 172/359 (47%), Gaps = 43/359 (11%)

Query: 23  ELNNMFGQIQSPGYPDSYPSDSEVTWNITVPDGFRIKLYFMHFNLESSYLCEYDYVKV-- 80
           E+    GQIQSP YPD Y    E  W ITV + + + L F  F +E    C YDY++V  
Sbjct: 465 EIRKNEGQIQSPNYPDDYRPMKECVWKITVSESYHVGLTFQSFEIERHDNCAYDYLEVRD 524

Query: 81  --ETEDQVLATFCGRETTDTEQTPGQEVVLSPGSFMSITFRSDFSNEERFTGFDAHYMAV 138
                  ++  FCG +          E + S  + + + F SD +  +   GF A++   
Sbjct: 525 GTSENSPLIGRFCGYDK--------PEDIRSTSNTLWMKFVSDGTVNK--AGFAANFFK- 573

Query: 139 DVDECKEREDEELSCDHYCHNYIGGYYCSCRFGYILHTDNRTCRVECSDNLFTQRTGVIT 198
           + DEC   + +   C+  C N +G Y C+C  GY L  D R+C   C   L T+  G IT
Sbjct: 574 EEDEC--AKPDRGGCEQRCLNTLGSYQCACEPGYELGPDRRSCEAACG-GLLTKLNGTIT 630

Query: 199 SPDFPNPYPKSSECLYTIELEEGFMVNLQFEDIFDIEDHPEVPCPYDYIKIKVG----PK 254
           +P +P  YP +  C++ +     + ++++FE  F++E + EV C YDY++I  G     K
Sbjct: 631 TPGWPKEYPPNKNCVWQVVAPTQYRISVKFE-FFELEGN-EV-CKYDYVEIWSGLSSESK 687

Query: 255 VLGPFCGEKAPEPISTQSHSVLILFHSDNSGENRGWRLSYRAAGNECPELQPPVHGKIEP 314
           + G FCG + PE I++Q +++ I F SDN+   +G++  + +  +EC +       +   
Sbjct: 688 LHGKFCGAEVPEVITSQFNNMRIEFKSDNTVSKKGFKAHFFSDKDECSKDNGGCQHECVN 747

Query: 315 SQAKYFFKDQVLVSCDTGYKVLKDNVEMDTFQIEC----------LKDGTWSNKIPTCK 363
           +   Y      +  C  G+ VL DN + D  + EC          +    W +K P+ K
Sbjct: 748 TMGSY------MCQCRNGF-VLHDN-KHDCKEAECEQKIHSPSGLITSPNWPDKYPSRK 798



 Score =  104 bits (260), Expect = 2e-22
 Identities = 91/330 (27%), Positives = 143/330 (43%), Gaps = 75/330 (22%)

Query: 17  ASAHTVELNNMFGQIQSPGYPDSYPSDSEVTWNITVPDGFRIKLYFMHFNLESSYLCEYD 76
           A   T++ +N  G + SPG+P+ YPS +   W ++V  G +I L F   +L  S LC YD
Sbjct: 348 ACGETLQESN--GNLSSPGFPNGYPSYTHCIWRVSVTPGEKIVLNFTTMDLYKSSLCWYD 405

Query: 77  YVKVE----TEDQVLATFCGRETTDTEQTPGQEVVLSPGSFMSITFRSDFSNEERFTGFD 132
           Y++V      +  +L  FCG      ++ P  EV+ S  S M I FRS  S+     GF 
Sbjct: 406 YIEVRDGYWRKSPLLGRFCG------DKLP--EVLTSTDSRMWIEFRS--SSNWVGKGFA 455

Query: 133 AHYMAVDVDECKEREDEELSCDHYCHNYIGGYYCSCRFGYILHTDNRTCRVECSDNLFTQ 192
           A Y A+   E ++ E                                             
Sbjct: 456 AVYEAICGGEIRKNE--------------------------------------------- 470

Query: 193 RTGVITSPDFPNPYPKSSECLYTIELEEGFMVNLQFEDIFDIEDHPEVPCPYDYIKIKVG 252
             G I SP++P+ Y    EC++ I + E + V L F+  F+IE H    C YDY++++ G
Sbjct: 471 --GQIQSPNYPDDYRPMKECVWKITVSESYHVGLTFQS-FEIERHDN--CAYDYLEVRDG 525

Query: 253 PK----VLGPFCGEKAPEPISTQSHSVLILFHSDNSGENRGWRLSYRAAGNECPELQPPV 308
                 ++G FCG   PE I + S+++ + F SD +    G+  ++    +EC +   P 
Sbjct: 526 TSENSPLIGRFCGYDKPEDIRSTSNTLWMKFVSDGTVNKAGFAANFFKEEDECAK---PD 582

Query: 309 HGKIEPSQAKYFFKDQVLVSCDTGYKVLKD 338
            G  E          Q   +C+ GY++  D
Sbjct: 583 RGGCEQRCLNTLGSYQ--CACEPGYELGPD 610



 Score =  101 bits (251), Expect = 3e-21
 Identities = 82/283 (28%), Positives = 123/283 (43%), Gaps = 66/283 (23%)

Query: 23   ELNNMFGQIQSPGYPDSYPSDSEVTWNITVPDGFRIKLYFMHFNLESSYLCEYDYVKV-- 80
            ++++  G I SP +PD YPS  E TW I+   G RIKL F  F +E    C YD+++V  
Sbjct: 777  KIHSPSGLITSPNWPDKYPSRKECTWEISATPGHRIKLAFSEFEIEQHQECAYDHLEVFD 836

Query: 81   -ETE-DQVLATFCGRETTDTEQTPGQEVVLSPGSFMSITFRSDFSNEERFTGFDAHYMAV 138
             ETE   +L   CG +  D         +++ G+ M + F SD S + +  GF A +   
Sbjct: 837  GETEKSPILGRLCGNKIPDP--------LVATGNKMFVRFVSDASVQRK--GFQATHST- 885

Query: 139  DVDECKER-EDEELSCDHYCHNYIGGYYCSCRFGYILHTDNRTCRVECSDNLFTQRTGVI 197
               EC  R + E    D Y H   G                                   
Sbjct: 886  ---ECGGRLKAESKPRDLYSHAQFG----------------------------------- 907

Query: 198  TSPDFPNPYPKSSECLYTIELEEGFMVNLQFEDIFDIEDHPEVPCPYDYIKIKVG----P 253
                  N YP   +C + +  E G  + L F+  F++E+  E  C YDY+++  G     
Sbjct: 908  -----DNNYPGQVDCEWLLVSERGSRLELSFQ-TFEVEE--EADCGYDYVELFDGLDSTA 959

Query: 254  KVLGPFCGEKAPEPISTQSHSVLILFHSDNSGENRGWRLSYRA 296
              LG FCG   PE I +   SVLI FH+D++   +G+ + Y++
Sbjct: 960  VGLGRFCGSGPPEEIYSIGDSVLIHFHTDDTINKKGFHIRYKS 1002


>gi|4826762 haptoglobin isoform 1 preproprotein [Homo sapiens]
          Length = 406

 Score =  159 bits (403), Expect = 6e-39
 Identities = 122/417 (29%), Positives = 187/417 (44%), Gaps = 64/417 (15%)

Query: 297 AGNECPELQPPVHGKIEPS---QAKYFFKDQVLVSCDTGYKVLKDNVEMDTFQIECLKDG 353
           A + CP+     HG +E S   Q K ++K   L +   G   L D  +     +      
Sbjct: 29  ADDGCPKPPEIAHGYVEHSVRYQCKNYYK---LRTEGDGVYTLNDKKQWINKAV------ 79

Query: 354 TWSNKIPTCKIVD-CRAPGELEHGLITFSTRNNLTTYKSEIKYSCQEPYYKMLNNNTGIY 412
              +K+P C+  D C  P E+ HG +  S R           Y C+  YYK+     G+Y
Sbjct: 80  --GDKLPECEADDGCPKPPEIAHGYVEHSVR-----------YQCKN-YYKLRTEGDGVY 125

Query: 413 TCSAQGVWMNKVLGRSLPTCLPVCGLPKFSRKLMARIFNGRPAQKGTTPWIA-MLSHLNG 471
           T + +  W+NK +G  LP C  VCG PK     + RI  G    KG+ PW A M+SH N 
Sbjct: 126 TLNNEKQWINKAVGDKLPECEAVCGKPKNPANPVQRILGGHLDAKGSFPWQAKMVSHHN- 184

Query: 472 QPFCGGSLLGSSWIVTAAHCLHQSLDPEDPTLRDSDLLSPSDFKIILGKHWRLRSDENEQ 531
               G +L+   W++T A  L  +   E+ T +D   ++P+   + +GK         +Q
Sbjct: 185 -LTTGATLINEQWLLTTAKNLFLN-HSENATAKD---IAPT-LTLYVGK---------KQ 229

Query: 532 HLGVKHTTLHPQYDPNTFENDVALVELLESPVLNAFVMPICLPEGPQQE-GAMVIVSGWG 590
            + ++   LHP Y     + D+ L++L +   +N  VMPICLP     E G +  VSGWG
Sbjct: 230 LVEIEKVVLHPNYS----QVDIGLIKLKQKVSVNERVMPICLPSKDYAEVGRVGYVSGWG 285

Query: 591 KQFLQRFPETLMEIEIPIVDHSTCQKAY----APLKKK----------VTRDMICAGEKE 636
           +    +F + L  + +P+ D   C + Y     P KK           +     CAG  +
Sbjct: 286 RNANFKFTDHLKYVMLPVADQDQCIRHYEGSTVPEKKTPKSPVGVQPILNEHTFCAGMSK 345

Query: 637 GGKDACAGDSGGPMVTLNRERGQWYLVGTVSWGDDCGKKDRYGVYSYIHHNKDWIQR 693
             +D C GD+G      + E   WY  G +S+   C   + YGVY  +   +DW+Q+
Sbjct: 346 YQEDTCYGDAGSAFAVHDLEEDTWYATGILSFDKSCAVAE-YGVYVKVTSIQDWVQK 401


>gi|187761337 transmembrane protease, serine 11B [Homo sapiens]
          Length = 416

 Score =  155 bits (392), Expect = 1e-37
 Identities = 89/253 (35%), Positives = 135/253 (53%), Gaps = 23/253 (9%)

Query: 448 RIFNGRPAQKGTTPWIAMLSHLNGQPFCGGSLLGSSWIVTAAHCLHQSLDPEDPTLRDSD 507
           +I NG+ + +G  PW A +    G+ +CG SL+ S W+++AAHC  +  + +D T+    
Sbjct: 184 KIVNGKSSLEGAWPWQASMQW-KGRHYCGASLISSRWLLSAAHCFAKKNNSKDWTV---- 238

Query: 508 LLSPSDFKIILGKHWRLRSDENEQHLGVKHTTLHPQYDPNTFENDVALVELLESPVLNAF 567
                +F I++ K +  R         V++   H  Y      +D+ALV+L E      +
Sbjct: 239 -----NFGIVVNKPYMTRK--------VQNIIFHENYSSPGLHDDIALVQLAEEVSFTEY 285

Query: 568 VMPICLPEGPQQ--EGAMVIVSGWGKQFLQ-RFPETLMEIEIPIVDHSTCQKAYAPLKKK 624
           +  ICLPE   +  E   V+V+GWG  ++   FP  L E  + I+D+  C  +YA     
Sbjct: 286 IRKICLPEAKMKLSENDNVVVTGWGTLYMNGSFPVILQEDFLKIIDNKICNASYA-YSGF 344

Query: 625 VTRDMICAGEKEGGKDACAGDSGGPMVTLNRERGQWYLVGTVSWGDDCGKKDRYGVYSYI 684
           VT  M+CAG   G  DAC  DSGGP+   +  R  W+LVG VSWGD CGKK++ GVY+ +
Sbjct: 345 VTDTMLCAGFMSGEADACQNDSGGPLAYPD-SRNIWHLVGIVSWGDGCGKKNKPGVYTRV 403

Query: 685 HHNKDWIQRVTGV 697
              ++WI   TG+
Sbjct: 404 TSYRNWITSKTGL 416


>gi|13994276 marapsin [Homo sapiens]
          Length = 290

 Score =  154 bits (388), Expect = 3e-37
 Identities = 89/271 (32%), Positives = 140/271 (51%), Gaps = 33/271 (12%)

Query: 436 CGLPKFSRKLMARIFNGRPAQKGTTPWIAMLSHLNGQPFCGGSLLGSSWIVTAAHCLHQS 495
           CG P+    ++ R+  G+  Q+G  PW   +   NG  FCGGSL+   W++TAAHC   +
Sbjct: 26  CGRPR----MLNRMVGGQDTQEGEWPWQVSIQR-NGSHFCGGSLIAEQWVLTAAHCFRNT 80

Query: 496 LDPEDPTLRDSDLLSPSDFKIILGKHWRLRSDENEQHLGVKHTTLHPQYDPNTFENDVAL 555
            +              S ++++LG    ++   +  +  V+    +P Y       DVAL
Sbjct: 81  SET-------------SLYQVLLGARQLVQPGPHAMYARVRQVESNPLYQGTASSADVAL 127

Query: 556 VELLESPV-LNAFVMPICLPEGPQ--QEGAMVIVSGWG---KQFLQRFPETLMEIEIPIV 609
           VEL E+PV    +++P+CLP+     + G    V+GWG   ++ L   P  L ++ +PI+
Sbjct: 128 VEL-EAPVPFTNYILPVCLPDPSVIFETGMNCWVTGWGSPSEEDLLPEPRILQKLAVPII 186

Query: 610 DHSTCQKAYAP------LKKKVTRDMICAGEKEGGKDACAGDSGGPMVTLNRERGQWYLV 663
           D   C   Y+         K +  DM+CAG +EG KDAC GDSGGP+V L  +   W   
Sbjct: 187 DTPKCNLLYSKDTEFGYQPKTIKNDMLCAGFEEGKKDACKGDSGGPLVCLVGQ--SWLQA 244

Query: 664 GTVSWGDDCGKKDRYGVYSYIHHNKDWIQRV 694
           G +SWG+ C +++R GVY  +  + +WI R+
Sbjct: 245 GVISWGEGCARQNRPGVYIRVTAHHNWIHRI 275


>gi|4506115 protein C [Homo sapiens]
          Length = 461

 Score =  153 bits (387), Expect = 5e-37
 Identities = 86/256 (33%), Positives = 132/256 (51%), Gaps = 33/256 (12%)

Query: 448 RIFNGRPAQKGTTPWIAMLSHLNGQPFCGGSLLGSSWIVTAAHCLHQSLDPEDPTLRDSD 507
           R+ +G+  ++G +PW  +L     +  CG  L+  SW++TAAHC+ +S            
Sbjct: 211 RLIDGKMTRRGDSPWQVVLLDSKKKLACGAVLIHPSWVLTAAHCMDES------------ 258

Query: 508 LLSPSDFKIILGKHWRLRSDENEQHLGVKHTTLHPQYDPNTFENDVALVELLESPVLNAF 567
                   + LG++   R ++ E  L +K   +HP Y  +T +ND+AL+ L +   L+  
Sbjct: 259 ----KKLLVRLGEYDLRRWEKWELDLDIKEVFVHPNYSKSTTDNDIALLHLAQPATLSQT 314

Query: 568 VMPICLPEGP------QQEGAMVIVSGWG------KQFLQRFPETLMEIEIPIVDHSTCQ 615
           ++PICLP+         Q G   +V+GWG      K+  +     L  I+IP+V H+ C 
Sbjct: 315 IVPICLPDSGLAERELNQAGQETLVTGWGYHSSREKEAKRNRTFVLNFIKIPVVPHNECS 374

Query: 616 KAYAPLKKKVTRDMICAGEKEGGKDACAGDSGGPMVTLNRERGQWYLVGTVSWGDDCGKK 675
           +    +   V+ +M+CAG     +DAC GDSGGPMV      G W+LVG VSWG+ CG  
Sbjct: 375 EV---MSNMVSENMLCAGILGDRQDACEGDSGGPMVA--SFHGTWFLVGLVSWGEGCGLL 429

Query: 676 DRYGVYSYIHHNKDWI 691
             YGVY+ +    DWI
Sbjct: 430 HNYGVYTKVSRYLDWI 445



 Score = 30.4 bits (67), Expect = 5.8
 Identities = 13/29 (44%), Positives = 14/29 (48%)

Query: 153 CDHYCHNYIGGYYCSCRFGYILHTDNRTC 181
           C HYC   +G   CSC  GY L  D   C
Sbjct: 147 CTHYCLEEVGWRRCSCAPGYKLGDDLLQC 175


>gi|4502421 bone morphogenetic protein 1 isoform 1 precursor [Homo
           sapiens]
          Length = 730

 Score =  153 bits (386), Expect = 6e-37
 Identities = 96/300 (32%), Positives = 146/300 (48%), Gaps = 30/300 (10%)

Query: 28  FGQIQSPGYPDSYPSDSEVTWNITVPDGFRIKLYFMHFNLESSYLCEYDYVKV----ETE 83
           +G IQSP YPD Y       W I V +GF + L F  F +E    C YDY++V       
Sbjct: 443 YGHIQSPNYPDDYRPSKVCIWRIQVSEGFHVGLTFQSFEIERHDSCAYDYLEVRDGHSES 502

Query: 84  DQVLATFCGRETTDTEQTPGQEVVLSPGSFMSITFRSDFSNEERFTGFDAHYMAVDVDEC 143
             ++  +CG E  D         + S  S + + F SD S  +   GF  ++   +VDEC
Sbjct: 503 STLIGRYCGYEKPDD--------IKSTSSRLWLKFVSDGSINK--AGFAVNFFK-EVDEC 551

Query: 144 KEREDEELSCDHYCHNYIGGYYCSCRFGYILHTDNRTCRVECSDNLFTQRTGVITSPDFP 203
                    C+  C N +G Y CSC  GY L  D R C   C     T+  G ITSP +P
Sbjct: 552 S--RPNRGGCEQRCLNTLGSYKCSCDPGYELAPDKRRCEAACG-GFLTKLNGSITSPGWP 608

Query: 204 NPYPKSSECLYTIELEEGFMVNLQFEDIFDIEDHPEVPCPYDYIKIKVG----PKVLGPF 259
             YP +  C++ +     + ++LQF D F+ E +    C YD+++++ G     K+ G F
Sbjct: 609 KEYPPNKNCIWQLVAPTQYRISLQF-DFFETEGND--VCKYDFVEVRSGLTADSKLHGKF 665

Query: 260 CGEKAPEPISTQSHSVLILFHSDNSGENRGWRLSYRAAGNECPELQPPVHGKIEPSQAKY 319
           CG + PE I++Q +++ + F SDN+   +G++  +     + P LQPP   +  P Q K+
Sbjct: 666 CGSEKPEVITSQYNNMRVEFKSDNTVSKKGFKAHF--FSEKRPALQPP---RGRPHQLKF 720



 Score = 95.9 bits (237), Expect = 1e-19
 Identities = 90/333 (27%), Positives = 137/333 (41%), Gaps = 73/333 (21%)

Query: 14  LSKASAHTVELNNMFGQIQSPGYPDSYPSDSEVTWNITVPDGFRIKLYFMHFNLESSYLC 73
           L K  A    L +  G   SP YP+ Y +     W I+V  G +I L F   +L  S LC
Sbjct: 316 LYKCPACGETLQDSTGNFSSPEYPNGYSAHMHCVWRISVTPGEKIILNFTSLDLYRSRLC 375

Query: 74  EYDYVKVE----TEDQVLATFCGRETTDTEQTPGQEVVLSPGSFMSITFRSDFSNEERFT 129
            YDYV+V      +  +   FCG +          E ++S  S + + FRS  S+     
Sbjct: 376 WYDYVEVRDGFWRKAPLRGRFCGSKL--------PEPIVSTDSRLWVEFRS--SSNWVGK 425

Query: 130 GFDAHYMAVDVDECKEREDEELSCDHYCHNYIGGYYCSCRFGYILHTDNRTCRVECSDNL 189
           GF A Y A+   + K+        D+                                  
Sbjct: 426 GFFAVYEAICGGDVKK--------DY---------------------------------- 443

Query: 190 FTQRTGVITSPDFPNPYPKSSECLYTIELEEGFMVNLQFEDIFDIEDHPEVPCPYDYIKI 249
                G I SP++P+ Y  S  C++ I++ EGF V L F+  F+IE H    C YDY+++
Sbjct: 444 -----GHIQSPNYPDDYRPSKVCIWRIQVSEGFHVGLTFQS-FEIERHDS--CAYDYLEV 495

Query: 250 KVG----PKVLGPFCGEKAPEPISTQSHSVLILFHSDNSGENRGWRLSYRAAGNECPELQ 305
           + G      ++G +CG + P+ I + S  + + F SD S    G+ +++    +EC    
Sbjct: 496 RDGHSESSTLIGRYCGYEKPDDIKSTSSRLWLKFVSDGSINKAGFAVNFFKEVDECSR-- 553

Query: 306 PPVHGKIEPSQAKYFFKDQVLVSCDTGYKVLKD 338
            P  G  E  Q           SCD GY++  D
Sbjct: 554 -PNRGGCE--QRCLNTLGSYKCSCDPGYELAPD 583



 Score = 67.0 bits (162), Expect = 6e-11
 Identities = 38/118 (32%), Positives = 58/118 (49%), Gaps = 14/118 (11%)

Query: 24  LNNMFGQIQSPGYPDSYPSDSEVTWNITVPDGFRIKLYFMHFNLESSYLCEYDYVKVET- 82
           L  + G I SPG+P  YP +    W +  P  +RI L F  F  E + +C+YD+V+V + 
Sbjct: 595 LTKLNGSITSPGWPKEYPPNKNCIWQLVAPTQYRISLQFDFFETEGNDVCKYDFVEVRSG 654

Query: 83  ---EDQVLATFCGRETTDTEQTPGQEVVLSPGSFMSITFRSDFSNEERFTGFDAHYMA 137
              + ++   FCG E          EV+ S  + M + F+SD  N     GF AH+ +
Sbjct: 655 LTADSKLHGKFCGSEK--------PEVITSQYNNMRVEFKSD--NTVSKKGFKAHFFS 702


>gi|4506145 protease, serine, 1 preproprotein [Homo sapiens]
          Length = 247

 Score =  151 bits (381), Expect = 2e-36
 Identities = 85/247 (34%), Positives = 127/247 (51%), Gaps = 31/247 (12%)

Query: 448 RIFNGRPAQKGTTPWIAMLSHLNGQPFCGGSLLGSSWIVTAAHCLHQSLDPEDPTLRDSD 507
           +I  G   ++ + P+   L+  +G  FCGGSL+   W+V+A HC                
Sbjct: 23  KIVGGYNCEENSVPYQVSLN--SGYHFCGGSLINEQWVVSAGHCYK-------------- 66

Query: 508 LLSPSDFKIILGKHWRLRSDENEQHLGVKHTTLHPQYDPNTFENDVALVELLESPVLNAF 567
               S  ++ LG+H     + NEQ +       HPQYD  T  ND+ L++L    V+NA 
Sbjct: 67  ----SRIQVRLGEHNIEVLEGNEQFINAAKIIRHPQYDRKTLNNDIMLIKLSSRAVINAR 122

Query: 568 VMPICLPEGPQQEGAMVIVSGWGKQFLQ--RFPETLMEIEIPIVDHSTCQKAYAPLKKKV 625
           V  I LP  P   G   ++SGWG        +P+ L  ++ P++  + C+ +Y     K+
Sbjct: 123 VSTISLPTAPPATGTKCLISGWGNTASSGADYPDELQCLDAPVLSQAKCEASY---PGKI 179

Query: 626 TRDMICAGEKEGGKDACAGDSGGPMVTLNRERGQWYLVGTVSWGDDCGKKDRYGVYSYIH 685
           T +M C G  EGGKD+C GDSGGP+V      GQ  L G VSWGD C +K++ GVY+ ++
Sbjct: 180 TSNMFCVGFLEGGKDSCQGDSGGPVVC----NGQ--LQGVVSWGDGCAQKNKPGVYTKVY 233

Query: 686 HNKDWIQ 692
           +   WI+
Sbjct: 234 NYVKWIK 240


>gi|4758508 transmembrane protease, serine 11D [Homo sapiens]
          Length = 418

 Score =  151 bits (381), Expect = 2e-36
 Identities = 102/322 (31%), Positives = 151/322 (46%), Gaps = 29/322 (9%)

Query: 380 FSTRNNLTTYKSEIKYSCQEPYYKMLNNNTGIYTCSAQGVWMNKVLGRSLPTCLPVCGL- 438
           F+  NN  + KS I     E   + + NN+G    +      +     +    +  CG  
Sbjct: 122 FTRNNNGASMKSRI-----ESVLRQMLNNSGNLEINPSTEITSLTDQAAANWLINECGAG 176

Query: 439 PKFSRKLMARIFNGRPAQKGTTPWIAMLSHLNGQPFCGGSLLGSSWIVTAAHCLHQSLDP 498
           P        RI  G  A++G+ PW   L  LN    CGGSL+ + WI+TAAHC   + +P
Sbjct: 177 PDLITLSEQRILGGTEAEEGSWPWQVSL-RLNNAHHCGGSLINNMWILTAAHCFRSNSNP 235

Query: 499 EDPTLRDSDLLSPSDFKIILGKHWRLRSDENEQHLGVKHTTLHPQYDPNTFENDVALVEL 558
            D        ++ S       K  R+R         V++  +H  Y   T END+ALV L
Sbjct: 236 RD-------WIATSGISTTFPK-LRMR---------VRNILIHNNYKSATHENDIALVRL 278

Query: 559 LESPVLNAFVMPICLPEGPQQ--EGAMVIVSGWGKQ-FLQRFPETLMEIEIPIVDHSTCQ 615
             S      +  +CLP   Q    G+   V+GWG Q +       L + ++ I+ +  C 
Sbjct: 279 ENSVTFTKDIHSVCLPAATQNIPPGSTAYVTGWGAQEYAGHTVPELRQGQVRIISNDVCN 338

Query: 616 KAYAPLKKKVTRDMICAGEKEGGKDACAGDSGGPMVTLNRERGQWYLVGTVSWGDDCGKK 675
             ++     +   M+CAG  +GG DAC GDSGGP+V  +  R  W++VG VSWGD CG  
Sbjct: 339 APHS-YNGAILSGMLCAGVPQGGVDACQGDSGGPLVQEDSRR-LWFIVGIVSWGDQCGLP 396

Query: 676 DRYGVYSYIHHNKDWIQRVTGV 697
           D+ GVY+ +    DWI++ TG+
Sbjct: 397 DKPGVYTRVTAYLDWIRQQTGI 418


>gi|186910296 haptoglobin isoform 2 preproprotein [Homo sapiens]
          Length = 347

 Score =  150 bits (380), Expect = 3e-36
 Identities = 104/343 (30%), Positives = 158/343 (46%), Gaps = 49/343 (14%)

Query: 367 CRAPGELEHGLITFSTRNNLTTYKSEIKYSCQEPYYKMLNNNTGIYTCSAQGVWMNKVLG 426
           C  P E+ HG +  S R           Y C+  YYK+     G+YT + +  W+NK +G
Sbjct: 33  CPKPPEIAHGYVEHSVR-----------YQCKN-YYKLRTEGDGVYTLNNEKQWINKAVG 80

Query: 427 RSLPTCLPVCGLPKFSRKLMARIFNGRPAQKGTTPWIA-MLSHLNGQPFCGGSLLGSSWI 485
             LP C  VCG PK     + RI  G    KG+ PW A M+SH N     G +L+   W+
Sbjct: 81  DKLPECEAVCGKPKNPANPVQRILGGHLDAKGSFPWQAKMVSHHN--LTTGATLINEQWL 138

Query: 486 VTAAHCLHQSLDPEDPTLRDSDLLSPSDFKIILGKHWRLRSDENEQHLGVKHTTLHPQYD 545
           +T A  L  +   E+ T +D   ++P+   + +GK         +Q + ++   LHP Y 
Sbjct: 139 LTTAKNLFLN-HSENATAKD---IAPT-LTLYVGK---------KQLVEIEKVVLHPNYS 184

Query: 546 PNTFENDVALVELLESPVLNAFVMPICLPEGPQQE-GAMVIVSGWGKQFLQRFPETLMEI 604
               + D+ L++L +   +N  VMPICLP     E G +  VSGWG+    +F + L  +
Sbjct: 185 ----QVDIGLIKLKQKVSVNERVMPICLPSKDYAEVGRVGYVSGWGRNANFKFTDHLKYV 240

Query: 605 EIPIVDHSTCQKAY----APLKKK----------VTRDMICAGEKEGGKDACAGDSGGPM 650
            +P+ D   C + Y     P KK           +     CAG  +  +D C GD+G   
Sbjct: 241 MLPVADQDQCIRHYEGSTVPEKKTPKSPVGVQPILNEHTFCAGMSKYQEDTCYGDAGSAF 300

Query: 651 VTLNRERGQWYLVGTVSWGDDCGKKDRYGVYSYIHHNKDWIQR 693
              + E   WY  G +S+   C   + YGVY  +   +DW+Q+
Sbjct: 301 AVHDLEEDTWYATGILSFDKSCAVAE-YGVYVKVTSIQDWVQK 342


>gi|4503649 coagulation factor IX preproprotein [Homo sapiens]
          Length = 461

 Score =  149 bits (375), Expect = 1e-35
 Identities = 88/257 (34%), Positives = 133/257 (51%), Gaps = 33/257 (12%)

Query: 448 RIFNGRPAQKGTTPWIAMLSHLNGQ--PFCGGSLLGSSWIVTAAHCLHQSLDPEDPTLRD 505
           R+  G  A+ G  PW  +L   NG+   FCGGS++   WIVTAAHC+   +         
Sbjct: 226 RVVGGEDAKPGQFPWQVVL---NGKVDAFCGGSIVNEKWIVTAAHCVETGVK-------- 274

Query: 506 SDLLSPSDFKIILGKHWRLRSDENEQHLGVKHTTLHPQYDP--NTFENDVALVELLESPV 563
                     ++ G+H    ++  EQ   V     H  Y+   N + +D+AL+EL E  V
Sbjct: 275 --------ITVVAGEHNIEETEHTEQKRNVIRIIPHHNYNAAINKYNHDIALLELDEPLV 326

Query: 564 LNAFVMPICLPEGPQQEGAMVI----VSGWGKQFLQ-RFPETLMEIEIPIVDHSTCQKAY 618
           LN++V PIC+ +       +      VSGWG+ F + R    L  + +P+VD +TC ++ 
Sbjct: 327 LNSYVTPICIADKEYTNIFLKFGSGYVSGWGRVFHKGRSALVLQYLRVPLVDRATCLRS- 385

Query: 619 APLKKKVTRDMICAGEKEGGKDACAGDSGGPMVTLNRERGQWYLVGTVSWGDDCGKKDRY 678
              K  +  +M CAG  EGG+D+C GDSGGP VT     G  +L G +SWG++C  K +Y
Sbjct: 386 --TKFTIYNNMFCAGFHEGGRDSCQGDSGGPHVT--EVEGTSFLTGIISWGEECAMKGKY 441

Query: 679 GVYSYIHHNKDWIQRVT 695
           G+Y+ +    +WI+  T
Sbjct: 442 GIYTKVSRYVNWIKEKT 458



 Score = 32.0 bits (71), Expect = 2.0
 Identities = 22/71 (30%), Positives = 31/71 (43%), Gaps = 9/71 (12%)

Query: 119 RSDFSNEERFTGFDAHYMAVDVDECKEREDEELSCDHYCHNYIGGYYCSCRFGYILHTDN 178
           R  F N ER T F   Y  VD D+C   E         C + I  Y C C FG+    + 
Sbjct: 75  REVFENTERTTEFWKQY--VDGDQC---ESNPCLNGGSCKDDINSYECWCPFGF----EG 125

Query: 179 RTCRVECSDNL 189
           + C ++ + N+
Sbjct: 126 KNCELDVTCNI 136


>gi|23957702 transmembrane protease, serine 6 [Homo sapiens]
          Length = 811

 Score =  148 bits (374), Expect = 1e-35
 Identities = 89/264 (33%), Positives = 137/264 (51%), Gaps = 27/264 (10%)

Query: 436 CGLPKFSRKLMARIFNGRPAQKGTTPWIAMLSHLNGQPFCGGSLLGSSWIVTAAHCLHQS 495
           CGL   S    +RI  G  + +G  PW A L  + G+  CGG+L+   W++TAAHC    
Sbjct: 568 CGLQGPS----SRIVGGAVSSEGEWPWQASLQ-VRGRHICGGALIADRWVITAAHCF--- 619

Query: 496 LDPEDPTLRDSDLLSPSDFKIILGKHWRLRSDENEQHLGVKHTTLHPQYDPNTFENDVAL 555
                   ++  + S   + + LGK W+      E    V    LHP ++ ++ + DVAL
Sbjct: 620 --------QEDSMASTVLWTVFLGKVWQNSRWPGEVSFKVSRLLLHPYHEEDSHDYDVAL 671

Query: 556 VELLESPVLNAFVMPICLPEGPQ--QEGAMVIVSGWGKQFLQR---FPETLMEIEIPIVD 610
           ++L    V +A V P+CLP      + G    ++GWG   L+        L ++++ ++ 
Sbjct: 672 LQLDHPVVRSAAVRPVCLPARSHFFEPGLHCWITGWGA--LREGGPISNALQKVDVQLIP 729

Query: 611 HSTCQKAYAPLKKKVTRDMICAGEKEGGKDACAGDSGGPMVTLNRERGQWYLVGTVSWGD 670
              C + Y   + +VT  M+CAG ++G KDAC GDSGGP+V      G+W+L G VSWG 
Sbjct: 730 QDLCSEVY---RYQVTPRMLCAGYRKGKKDACQGDSGGPLVC-KALSGRWFLAGLVSWGL 785

Query: 671 DCGKKDRYGVYSYIHHNKDWIQRV 694
            CG+ + +GVY+ I     WIQ+V
Sbjct: 786 GCGRPNYFGVYTRITGVISWIQQV 809


>gi|4506147 protease, serine, 2 preproprotein [Homo sapiens]
          Length = 247

 Score =  147 bits (372), Expect = 2e-35
 Identities = 83/247 (33%), Positives = 129/247 (52%), Gaps = 31/247 (12%)

Query: 448 RIFNGRPAQKGTTPWIAMLSHLNGQPFCGGSLLGSSWIVTAAHCLHQSLDPEDPTLRDSD 507
           +I  G   ++ + P+   L+  +G  FCGGSL+   W+V+A HC                
Sbjct: 23  KIVGGYICEENSVPYQVSLN--SGYHFCGGSLISEQWVVSAGHCYK-------------- 66

Query: 508 LLSPSDFKIILGKHWRLRSDENEQHLGVKHTTLHPQYDPNTFENDVALVELLESPVLNAF 567
               S  ++ LG+H     + NEQ +       HP+Y+  T +ND+ L++L    V+N+ 
Sbjct: 67  ----SRIQVRLGEHNIEVLEGNEQFINAAKIIRHPKYNSRTLDNDILLIKLSSPAVINSR 122

Query: 568 VMPICLPEGPQQEGAMVIVSGWGKQFLQ--RFPETLMEIEIPIVDHSTCQKAYAPLKKKV 625
           V  I LP  P   G   ++SGWG        +P+ L  ++ P++  + C+ +Y     K+
Sbjct: 123 VSAISLPTAPPAAGTESLISGWGNTLSSGADYPDELQCLDAPVLSQAECEASY---PGKI 179

Query: 626 TRDMICAGEKEGGKDACAGDSGGPMVTLNRERGQWYLVGTVSWGDDCGKKDRYGVYSYIH 685
           T +M C G  EGGKD+C GDSGGP+V+ N E     L G VSWG  C +K+R GVY+ ++
Sbjct: 180 TNNMFCVGFLEGGKDSCQGDSGGPVVS-NGE-----LQGIVSWGYGCAQKNRPGVYTKVY 233

Query: 686 HNKDWIQ 692
           +  DWI+
Sbjct: 234 NYVDWIK 240


>gi|5902808 bone morphogenetic protein 1 isoform 2 precursor [Homo
           sapiens]
          Length = 823

 Score =  147 bits (372), Expect = 2e-35
 Identities = 88/275 (32%), Positives = 135/275 (49%), Gaps = 25/275 (9%)

Query: 28  FGQIQSPGYPDSYPSDSEVTWNITVPDGFRIKLYFMHFNLESSYLCEYDYVKV----ETE 83
           +G IQSP YPD Y       W I V +GF + L F  F +E    C YDY++V       
Sbjct: 443 YGHIQSPNYPDDYRPSKVCIWRIQVSEGFHVGLTFQSFEIERHDSCAYDYLEVRDGHSES 502

Query: 84  DQVLATFCGRETTDTEQTPGQEVVLSPGSFMSITFRSDFSNEERFTGFDAHYMAVDVDEC 143
             ++  +CG E  D         + S  S + + F SD S  +   GF  ++   +VDEC
Sbjct: 503 STLIGRYCGYEKPDD--------IKSTSSRLWLKFVSDGSINK--AGFAVNFFK-EVDEC 551

Query: 144 KEREDEELSCDHYCHNYIGGYYCSCRFGYILHTDNRTCRVECSDNLFTQRTGVITSPDFP 203
                    C+  C N +G Y CSC  GY L  D R C   C     T+  G ITSP +P
Sbjct: 552 S--RPNRGGCEQRCLNTLGSYKCSCDPGYELAPDKRRCEAACG-GFLTKLNGSITSPGWP 608

Query: 204 NPYPKSSECLYTIELEEGFMVNLQFEDIFDIEDHPEVPCPYDYIKIKVG----PKVLGPF 259
             YP +  C++ +     + ++LQF D F+ E +    C YD+++++ G     K+ G F
Sbjct: 609 KEYPPNKNCIWQLVAPTQYRISLQF-DFFETEGND--VCKYDFVEVRSGLTADSKLHGKF 665

Query: 260 CGEKAPEPISTQSHSVLILFHSDNSGENRGWRLSY 294
           CG + PE I++Q +++ + F SDN+   +G++  +
Sbjct: 666 CGSEKPEVITSQYNNMRVEFKSDNTVSKKGFKAHF 700



 Score = 95.9 bits (237), Expect = 1e-19
 Identities = 90/333 (27%), Positives = 137/333 (41%), Gaps = 73/333 (21%)

Query: 14  LSKASAHTVELNNMFGQIQSPGYPDSYPSDSEVTWNITVPDGFRIKLYFMHFNLESSYLC 73
           L K  A    L +  G   SP YP+ Y +     W I+V  G +I L F   +L  S LC
Sbjct: 316 LYKCPACGETLQDSTGNFSSPEYPNGYSAHMHCVWRISVTPGEKIILNFTSLDLYRSRLC 375

Query: 74  EYDYVKVE----TEDQVLATFCGRETTDTEQTPGQEVVLSPGSFMSITFRSDFSNEERFT 129
            YDYV+V      +  +   FCG +          E ++S  S + + FRS  S+     
Sbjct: 376 WYDYVEVRDGFWRKAPLRGRFCGSKL--------PEPIVSTDSRLWVEFRS--SSNWVGK 425

Query: 130 GFDAHYMAVDVDECKEREDEELSCDHYCHNYIGGYYCSCRFGYILHTDNRTCRVECSDNL 189
           GF A Y A+   + K+        D+                                  
Sbjct: 426 GFFAVYEAICGGDVKK--------DY---------------------------------- 443

Query: 190 FTQRTGVITSPDFPNPYPKSSECLYTIELEEGFMVNLQFEDIFDIEDHPEVPCPYDYIKI 249
                G I SP++P+ Y  S  C++ I++ EGF V L F+  F+IE H    C YDY+++
Sbjct: 444 -----GHIQSPNYPDDYRPSKVCIWRIQVSEGFHVGLTFQS-FEIERHDS--CAYDYLEV 495

Query: 250 KVG----PKVLGPFCGEKAPEPISTQSHSVLILFHSDNSGENRGWRLSYRAAGNECPELQ 305
           + G      ++G +CG + P+ I + S  + + F SD S    G+ +++    +EC    
Sbjct: 496 RDGHSESSTLIGRYCGYEKPDDIKSTSSRLWLKFVSDGSINKAGFAVNFFKEVDECSR-- 553

Query: 306 PPVHGKIEPSQAKYFFKDQVLVSCDTGYKVLKD 338
            P  G  E  Q           SCD GY++  D
Sbjct: 554 -PNRGGCE--QRCLNTLGSYKCSCDPGYELAPD 583



 Score = 68.6 bits (166), Expect = 2e-11
 Identities = 39/119 (32%), Positives = 59/119 (49%), Gaps = 14/119 (11%)

Query: 24  LNNMFGQIQSPGYPDSYPSDSEVTWNITVPDGFRIKLYFMHFNLESSYLCEYDYVKVET- 82
           L  + G I SPG+P  YP +    W +  P  +RI L F  F  E + +C+YD+V+V + 
Sbjct: 595 LTKLNGSITSPGWPKEYPPNKNCIWQLVAPTQYRISLQFDFFETEGNDVCKYDFVEVRSG 654

Query: 83  ---EDQVLATFCGRETTDTEQTPGQEVVLSPGSFMSITFRSDFSNEERFTGFDAHYMAV 138
              + ++   FCG E          EV+ S  + M + F+SD  N     GF AH+ +V
Sbjct: 655 LTADSKLHGKFCGSEK--------PEVITSQYNNMRVEFKSD--NTVSKKGFKAHFFSV 703


>gi|170296790 mesotrypsin isoform 1 preproprotein [Homo sapiens]
          Length = 304

 Score =  147 bits (372), Expect = 2e-35
 Identities = 84/247 (34%), Positives = 128/247 (51%), Gaps = 31/247 (12%)

Query: 448 RIFNGRPAQKGTTPWIAMLSHLNGQPFCGGSLLGSSWIVTAAHCLHQSLDPEDPTLRDSD 507
           +I  G   ++ + P+   L+  +G  FCGGSL+   W+V+AAHC    +           
Sbjct: 80  KIVGGYTCEENSLPYQVSLN--SGSHFCGGSLISEQWVVSAAHCYKTRI----------- 126

Query: 508 LLSPSDFKIILGKHWRLRSDENEQHLGVKHTTLHPQYDPNTFENDVALVELLESPVLNAF 567
                  ++ LG+H     + NEQ +       HP+Y+ +T +ND+ L++L    V+NA 
Sbjct: 127 -------QVRLGEHNIKVLEGNEQFINAAKIIRHPKYNRDTLDNDIMLIKLSSPAVINAR 179

Query: 568 VMPICLPEGPQQEGAMVIVSGWGK--QFLQRFPETLMEIEIPIVDHSTCQKAYAPLKKKV 625
           V  I LP  P   G   ++SGWG    F   +P+ L  ++ P++  + C+ +Y     K+
Sbjct: 180 VSTISLPTAPPAAGTECLISGWGNTLSFGADYPDELKCLDAPVLTQAECKASY---PGKI 236

Query: 626 TRDMICAGEKEGGKDACAGDSGGPMVTLNRERGQWYLVGTVSWGDDCGKKDRYGVYSYIH 685
           T  M C G  EGGKD+C  DSGGP+V      GQ  L G VSWG  C  K+R GVY+ ++
Sbjct: 237 TNSMFCVGFLEGGKDSCQRDSGGPVVC----NGQ--LQGVVSWGHGCAWKNRPGVYTKVY 290

Query: 686 HNKDWIQ 692
           +  DWI+
Sbjct: 291 NYVDWIK 297


>gi|21536452 mesotrypsin isoform 2 preproprotein [Homo sapiens]
          Length = 247

 Score =  147 bits (372), Expect = 2e-35
 Identities = 84/247 (34%), Positives = 128/247 (51%), Gaps = 31/247 (12%)

Query: 448 RIFNGRPAQKGTTPWIAMLSHLNGQPFCGGSLLGSSWIVTAAHCLHQSLDPEDPTLRDSD 507
           +I  G   ++ + P+   L+  +G  FCGGSL+   W+V+AAHC    +           
Sbjct: 23  KIVGGYTCEENSLPYQVSLN--SGSHFCGGSLISEQWVVSAAHCYKTRI----------- 69

Query: 508 LLSPSDFKIILGKHWRLRSDENEQHLGVKHTTLHPQYDPNTFENDVALVELLESPVLNAF 567
                  ++ LG+H     + NEQ +       HP+Y+ +T +ND+ L++L    V+NA 
Sbjct: 70  -------QVRLGEHNIKVLEGNEQFINAAKIIRHPKYNRDTLDNDIMLIKLSSPAVINAR 122

Query: 568 VMPICLPEGPQQEGAMVIVSGWGK--QFLQRFPETLMEIEIPIVDHSTCQKAYAPLKKKV 625
           V  I LP  P   G   ++SGWG    F   +P+ L  ++ P++  + C+ +Y     K+
Sbjct: 123 VSTISLPTAPPAAGTECLISGWGNTLSFGADYPDELKCLDAPVLTQAECKASY---PGKI 179

Query: 626 TRDMICAGEKEGGKDACAGDSGGPMVTLNRERGQWYLVGTVSWGDDCGKKDRYGVYSYIH 685
           T  M C G  EGGKD+C  DSGGP+V      GQ  L G VSWG  C  K+R GVY+ ++
Sbjct: 180 TNSMFCVGFLEGGKDSCQRDSGGPVVC----NGQ--LQGVVSWGHGCAWKNRPGVYTKVY 233

Query: 686 HNKDWIQ 692
           +  DWI+
Sbjct: 234 NYVDWIK 240


>gi|11545839 protease, serine, 22 [Homo sapiens]
          Length = 317

 Score =  147 bits (372), Expect = 2e-35
 Identities = 91/272 (33%), Positives = 136/272 (50%), Gaps = 33/272 (12%)

Query: 434 PVCGLPKFSRKLMARIFNGRPAQKGTTPWIAMLSHLNGQPFCGGSLLGSSWIVTAAHCLH 493
           P CG P+     + R+  G  +     PWI  +   NG   C GSLL S W++TAAHC  
Sbjct: 39  PACGKPQ----QLNRVVGGEDSTDSEWPWIVSIQK-NGTHHCAGSLLTSRWVITAAHCFK 93

Query: 494 QSLDPEDPTLRDSDLLSPSDFKIILGKHWRLRSD-ENEQHLGVKHTTLHPQYDPNTFE-N 551
            +L+             P  F ++LG  W+L +     Q +GV     HP Y        
Sbjct: 94  DNLN------------KPYLFSVLLGA-WQLGNPGSRSQKVGVAWVEPHPVYSWKEGACA 140

Query: 552 DVALVELLESPVLNAFVMPICLPEGPQQ--EGAMVIVSGWGKQFLQR-----FPETLMEI 604
           D+ALV L  S   +  V+PICLP+            +SGWG   +Q       P+TL ++
Sbjct: 141 DIALVRLERSIQFSERVLPICLPDASIHLPPNTHCWISGWGS--IQDGVPLPHPQTLQKL 198

Query: 605 EIPIVDHSTCQKAY--APLKKKVTRDMICAGEKEGGKDACAGDSGGPMVTLNRERGQWYL 662
           ++PI+D   C   Y     +  +T DM+CAG  EG +DAC GDSGGP++   +  G W L
Sbjct: 199 KVPIIDSEVCSHLYWRGAGQGPITEDMLCAGYLEGERDACLGDSGGPLMC--QVDGAWLL 256

Query: 663 VGTVSWGDDCGKKDRYGVYSYIHHNKDWIQRV 694
            G +SWG+ C +++R GVY  +  ++ W++++
Sbjct: 257 AGIISWGEGCAERNRPGVYISLSAHRSWVEKI 288


>gi|4503635 coagulation factor II preproprotein [Homo sapiens]
          Length = 622

 Score =  147 bits (371), Expect = 3e-35
 Identities = 89/265 (33%), Positives = 139/265 (52%), Gaps = 29/265 (10%)

Query: 448 RIFNGRPAQKGTTPWIAMLSHLNGQPF-CGGSLLGSSWIVTAAHCLHQSLDPEDPTLRDS 506
           RI  G  A+ G +PW  ML   + Q   CG SL+   W++TAAHCL     P D    ++
Sbjct: 363 RIVEGSDAEIGMSPWQVMLFRKSPQELLCGASLISDRWVLTAAHCL--LYPPWDKNFTEN 420

Query: 507 DLLSPSDFKIILGKHWRLRSDENEQHLGV-KHTTLHPQYD-PNTFENDVALVELLESPVL 564
           DLL      + +GKH R R + N + + + +   +HP+Y+     + D+AL++L +    
Sbjct: 421 DLL------VRIGKHSRTRYERNIEKISMLEKIYIHPRYNWRENLDRDIALMKLKKPVAF 474

Query: 565 NAFVMPICLPEGPQ-----QEGAMVIVSGWGK-------QFLQRFPETLMEIEIPIVDHS 612
           + ++ P+CLP+        Q G    V+GWG           +  P  L  + +PIV+  
Sbjct: 475 SDYIHPVCLPDRETAASLLQAGYKGRVTGWGNLKETWTANVGKGQPSVLQVVNLPIVERP 534

Query: 613 TCQKAYAPLKKKVTRDMICAGEK--EGGK-DACAGDSGGPMVTLNRERGQWYLVGTVSWG 669
            C+ +    + ++T +M CAG K  EG + DAC GDSGGP V  +    +WY +G VSWG
Sbjct: 535 VCKDS---TRIRITDNMFCAGYKPDEGKRGDACEGDSGGPFVMKSPFNNRWYQMGIVSWG 591

Query: 670 DDCGKKDRYGVYSYIHHNKDWIQRV 694
           + C +  +YG Y+++   K WIQ+V
Sbjct: 592 EGCDRDGKYGFYTHVFRLKKWIQKV 616


>gi|145275213 coagulation factor XII precursor [Homo sapiens]
          Length = 615

 Score =  147 bits (371), Expect = 3e-35
 Identities = 90/260 (34%), Positives = 134/260 (51%), Gaps = 26/260 (10%)

Query: 446 MARIFNGRPAQKGTTPWIAMLSHLNGQPFCGGSLLGSSWIVTAAHCLHQSLDPEDPTLRD 505
           M R+  G  A +G  P+IA L    G  FC GSL+   W++TAAHCL             
Sbjct: 370 MTRVVGGLVALRGAHPYIAALYW--GHSFCAGSLIAPCWVLTAAHCL------------- 414

Query: 506 SDLLSPSDFKIILGKHWRLRSDENEQHLGVKHTTLHPQYDPNTFENDVALVELLES---- 561
            D  +P D  ++LG+  R  S E  Q L V+   LH  + P ++++D+AL+ L E     
Sbjct: 415 QDRPAPEDLTVVLGQERRNHSCEPCQTLAVRSYRLHEAFSPVSYQHDLALLRLQEDADGS 474

Query: 562 -PVLNAFVMPICLPEGPQQ--EGAMVIVSGWGKQF--LQRFPETLMEIEIPIVDHSTCQK 616
             +L+ +V P+CLP G  +  E  +  V+GWG QF   + +   L E ++P +    C  
Sbjct: 475 CALLSPYVQPVCLPSGAARPSETTLCQVAGWGHQFEGAEEYASFLQEAQVPFLSLERC-S 533

Query: 617 AYAPLKKKVTRDMICAGEKEGGKDACAGDSGGPMVTLNR-ERGQWYLVGTVSWGDDCGKK 675
           A       +   M+CAG  EGG DAC GDSGGP+V  ++    +  L G +SWG  CG +
Sbjct: 534 APDVHGSSILPGMLCAGFLEGGTDACQGDSGGPLVCEDQAAERRLTLQGIISWGSGCGDR 593

Query: 676 DRYGVYSYIHHNKDWIQRVT 695
           ++ GVY+ + +   WI+  T
Sbjct: 594 NKPGVYTDVAYYLAWIREHT 613


>gi|4503627 coagulation factor XI precursor [Homo sapiens]
          Length = 625

 Score =  147 bits (371), Expect = 3e-35
 Identities = 91/257 (35%), Positives = 133/257 (51%), Gaps = 22/257 (8%)

Query: 444 KLMARIFNGRPAQKGTTPWIAMLSHLNG--QPFCGGSLLGSSWIVTAAHCLHQSLDPEDP 501
           K+  RI  G  + +G  PW   L   +   +  CGGS++G+ WI+TAAHC +    P+  
Sbjct: 383 KIKPRIVGGTASVRGEWPWQVTLHTTSPTQRHLCGGSIIGNQWILTAAHCFYGVESPKIL 442

Query: 502 TLRDSDLLSPSDFKIILGKHWRLRSDENEQHLGVKHTTLHPQYDPNTFENDVALVELLES 561
            +  S +L+ S+ K            E+    GV+   +H QY       D+AL++L  +
Sbjct: 443 RVY-SGILNQSEIK------------EDTSFFGVQEIIIHDQYKMAESGYDIALLKLETT 489

Query: 562 PVLNAFVMPICLPEGPQQEGAMVI--VSGWGKQFLQ-RFPETLMEIEIPIVDHSTCQKAY 618
                   PICLP    +        V+GWG + L+ +   TL + +IP+V +  CQK Y
Sbjct: 490 VNYTDSQRPICLPSKGDRNVIYTDCWVTGWGYRKLRDKIQNTLQKAKIPLVTNEECQKRY 549

Query: 619 APLKKKVTRDMICAGEKEGGKDACAGDSGGPMVTLNRERGQWYLVGTVSWGDDCGKKDRY 678
                K+T  MICAG +EGGKDAC GDSGGP+   + E   W+LVG  SWG+ C +++R 
Sbjct: 550 RG--HKITHKMICAGYREGGKDACKGDSGGPLSCKHNE--VWHLVGITSWGEGCAQRERP 605

Query: 679 GVYSYIHHNKDWIQRVT 695
           GVY+ +    DWI   T
Sbjct: 606 GVYTNVVEYVDWILEKT 622


  Database: hs.faa
    Posted date:  Aug 4, 2009  4:42 PM
  Number of letters in database: 18,247,518
  Number of sequences in database:  37,866
  
Lambda     K      H
   0.320    0.137    0.440 

Gapped
Lambda     K      H
   0.267   0.0410    0.140 


Matrix: BLOSUM62
Gap Penalties: Existence: 11, Extension: 1
Number of Hits to DB: 31,686,266
Number of Sequences: 37866
Number of extensions: 1601602
Number of successful extensions: 5563
Number of sequences better than 10.0: 30
Number of HSP's better than 10.0 without gapping: 323
Number of HSP's successfully gapped in prelim test: 78
Number of HSP's that attempted gapping in prelim test: 3184
Number of HSP's gapped (non-prelim): 1508
length of query: 699
length of database: 18,247,518
effective HSP length: 109
effective length of query: 590
effective length of database: 14,120,124
effective search space: 8330873160
effective search space used: 8330873160
T: 11
A: 40
X1: 16 ( 7.4 bits)
X2: 38 (14.6 bits)
X3: 64 (24.7 bits)
S1: 41 (21.8 bits)
S2: 65 (29.6 bits)
Search results were obtained with NCBI BLAST and RefSeq entries.