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Search of human proteins with 21264343
BLASTP 2.2.11 [Jun-05-2005]
Reference: Altschul, Stephen F., Thomas L. Madden, Alejandro A. Schaffer,
Jinghui Zhang, Zheng Zhang, Webb Miller, and David J. Lipman (1997),
"Gapped BLAST and PSI-BLAST: a new generation of protein database search
programs", Nucleic Acids Res. 25:3389-3402.
Query= gi|21264343 scaffold attachment factor B [Homo sapiens]
(915 letters)
Database: hs.faa
37,866 sequences; 18,247,518 total letters
Searching..................................................done
Score E
Sequences producing significant alignments: (bits) Value
gi|21264343 scaffold attachment factor B [Homo sapiens] 1836 0.0
gi|7661936 scaffold attachment factor B2 [Homo sapiens] 1272 0.0
gi|63176611 modulator of estrogen induced transcription isoform ... 425 e-118
gi|62244004 modulator of estrogen induced transcription isoform ... 421 e-117
gi|239747134 PREDICTED: hypothetical protein XP_002343921 [Homo ... 100 5e-21
gi|89001107 dentin sialophosphoprotein preproprotein [Homo sapiens] 83 1e-15
gi|102467242 inner centromere protein antigens 135/155kDa isofor... 81 5e-15
gi|116008442 zinc finger CCCH-type containing 13 [Homo sapiens] 81 5e-15
gi|148746195 trichohyalin [Homo sapiens] 80 1e-14
gi|239754909 PREDICTED: hypothetical protein [Homo sapiens] 79 1e-14
gi|56549694 enabled homolog isoform a [Homo sapiens] 77 6e-14
gi|39930375 enabled homolog isoform b [Homo sapiens] 77 6e-14
gi|102467235 inner centromere protein antigens 135/155kDa isofor... 77 6e-14
gi|84043963 eukaryotic translation initiation factor 5B [Homo sa... 77 7e-14
gi|224548936 hypothetical protein LOC100170229 [Homo sapiens] 76 2e-13
gi|55741709 RNA binding motif protein 25 [Homo sapiens] 75 3e-13
gi|239749449 PREDICTED: hypothetical protein [Homo sapiens] 75 4e-13
gi|32483416 neurofilament, heavy polypeptide 200kDa [Homo sapiens] 74 6e-13
gi|4503509 eukaryotic translation initiation factor 3, subunit 1... 73 1e-12
gi|44680105 caldesmon 1 isoform 1 [Homo sapiens] 72 2e-12
gi|22035604 mitogen-activated protein kinase kinase kinase kinas... 72 2e-12
gi|22035606 mitogen-activated protein kinase kinase kinase kinas... 72 3e-12
gi|21040326 SON DNA-binding protein isoform F [Homo sapiens] 71 5e-12
gi|21040314 SON DNA-binding protein isoform B [Homo sapiens] 71 5e-12
gi|16332372 cell division cycle 2-like 1 (PITSLRE proteins) isof... 70 7e-12
gi|16332358 cell division cycle 2-like 1 (PITSLRE proteins) isof... 70 7e-12
gi|239757964 PREDICTED: hypothetical protein [Homo sapiens] 69 2e-11
gi|217330641 IWS1 homolog [Homo sapiens] 69 2e-11
gi|42560244 peptidylprolyl isomerase G [Homo sapiens] 69 2e-11
gi|148763347 cell division cycle 2-like 2 isoform 1 [Homo sapiens] 69 3e-11
>gi|21264343 scaffold attachment factor B [Homo sapiens]
Length = 915
Score = 1836 bits (4755), Expect = 0.0
Identities = 915/915 (100%), Positives = 915/915 (100%)
Query: 1 MAETLSGLGDSGAAGAAALSSASSETGTRRLSDLRVIDLRAELRKRNVDSSGNKSVLMER 60
MAETLSGLGDSGAAGAAALSSASSETGTRRLSDLRVIDLRAELRKRNVDSSGNKSVLMER
Sbjct: 1 MAETLSGLGDSGAAGAAALSSASSETGTRRLSDLRVIDLRAELRKRNVDSSGNKSVLMER 60
Query: 61 LKKAIEDEGGNPDEIEITSEGNKKTSKRSSKGRKPEEEGVEDNGLEENSGDGQEDVETSL 120
LKKAIEDEGGNPDEIEITSEGNKKTSKRSSKGRKPEEEGVEDNGLEENSGDGQEDVETSL
Sbjct: 61 LKKAIEDEGGNPDEIEITSEGNKKTSKRSSKGRKPEEEGVEDNGLEENSGDGQEDVETSL 120
Query: 121 ENLQDIDIMDISVLDEAEIDNGSVADCVEDDDADNLQESLSDSRELVEGEMKELPEQLQE 180
ENLQDIDIMDISVLDEAEIDNGSVADCVEDDDADNLQESLSDSRELVEGEMKELPEQLQE
Sbjct: 121 ENLQDIDIMDISVLDEAEIDNGSVADCVEDDDADNLQESLSDSRELVEGEMKELPEQLQE 180
Query: 181 HAIEDKETINNLDTSSSDFTILQEIEEPSLEPENEKILDILGETCKSEPVKEESSELEQP 240
HAIEDKETINNLDTSSSDFTILQEIEEPSLEPENEKILDILGETCKSEPVKEESSELEQP
Sbjct: 181 HAIEDKETINNLDTSSSDFTILQEIEEPSLEPENEKILDILGETCKSEPVKEESSELEQP 240
Query: 241 FAQDTSSVGPDRKLAEEEDLFDSAHPEEGDLDLASESTAHAQSSKADSLLAVVKREPAEQ 300
FAQDTSSVGPDRKLAEEEDLFDSAHPEEGDLDLASESTAHAQSSKADSLLAVVKREPAEQ
Sbjct: 241 FAQDTSSVGPDRKLAEEEDLFDSAHPEEGDLDLASESTAHAQSSKADSLLAVVKREPAEQ 300
Query: 301 PGDGERTDCEPVGLEPAVEQSSAASELAEASSEELAEAPTEAPSPEARDSKEDGRKFDFD 360
PGDGERTDCEPVGLEPAVEQSSAASELAEASSEELAEAPTEAPSPEARDSKEDGRKFDFD
Sbjct: 301 PGDGERTDCEPVGLEPAVEQSSAASELAEASSEELAEAPTEAPSPEARDSKEDGRKFDFD 360
Query: 361 ACNEVPPAPKESSTSEGADQKMSSPEDDSDTKRLSKEEKGRSSCGRNFWVSGLSSTTRAT 420
ACNEVPPAPKESSTSEGADQKMSSPEDDSDTKRLSKEEKGRSSCGRNFWVSGLSSTTRAT
Sbjct: 361 ACNEVPPAPKESSTSEGADQKMSSPEDDSDTKRLSKEEKGRSSCGRNFWVSGLSSTTRAT 420
Query: 421 DLKNLFSKYGKVVGAKVVTNARSPGARCYGFVTMSTAEEATKCINHLHKTELHGKMISVE 480
DLKNLFSKYGKVVGAKVVTNARSPGARCYGFVTMSTAEEATKCINHLHKTELHGKMISVE
Sbjct: 421 DLKNLFSKYGKVVGAKVVTNARSPGARCYGFVTMSTAEEATKCINHLHKTELHGKMISVE 480
Query: 481 KAKNEPVGKKTSDKRDSDGKKEKSSNSDRSTNLKRDDKCDRKDDAKKGDDGSGEKSKDQD 540
KAKNEPVGKKTSDKRDSDGKKEKSSNSDRSTNLKRDDKCDRKDDAKKGDDGSGEKSKDQD
Sbjct: 481 KAKNEPVGKKTSDKRDSDGKKEKSSNSDRSTNLKRDDKCDRKDDAKKGDDGSGEKSKDQD 540
Query: 541 DQKPGPSERSRATKSGSRGTERTVVMDKSKGVPVISVKTSGSKERASKSQDRKSASREKR 600
DQKPGPSERSRATKSGSRGTERTVVMDKSKGVPVISVKTSGSKERASKSQDRKSASREKR
Sbjct: 541 DQKPGPSERSRATKSGSRGTERTVVMDKSKGVPVISVKTSGSKERASKSQDRKSASREKR 600
Query: 601 SVVSFDKVKEPRKSRDSESHSRVRERSEREQRMQAQWEREERERLEIARERLAFQRQRLE 660
SVVSFDKVKEPRKSRDSESHSRVRERSEREQRMQAQWEREERERLEIARERLAFQRQRLE
Sbjct: 601 SVVSFDKVKEPRKSRDSESHSRVRERSEREQRMQAQWEREERERLEIARERLAFQRQRLE 660
Query: 661 RERMERERLERERMHVEHERRREQERIHREREELRRQQELRYEQERRPAVRRPYDLDRRD 720
RERMERERLERERMHVEHERRREQERIHREREELRRQQELRYEQERRPAVRRPYDLDRRD
Sbjct: 661 RERMERERLERERMHVEHERRREQERIHREREELRRQQELRYEQERRPAVRRPYDLDRRD 720
Query: 721 DAYWPEAKRAALDERYHSDFNRQDRFHDFDHRDRGRYPDHSVDRREGSRSMMGEREGQHY 780
DAYWPEAKRAALDERYHSDFNRQDRFHDFDHRDRGRYPDHSVDRREGSRSMMGEREGQHY
Sbjct: 721 DAYWPEAKRAALDERYHSDFNRQDRFHDFDHRDRGRYPDHSVDRREGSRSMMGEREGQHY 780
Query: 781 PERHGGPERHGRDSRDGWGGYGSDKRMSEGRGLPPPPRRDWGDHGRREDDRSWQGTADGG 840
PERHGGPERHGRDSRDGWGGYGSDKRMSEGRGLPPPPRRDWGDHGRREDDRSWQGTADGG
Sbjct: 781 PERHGGPERHGRDSRDGWGGYGSDKRMSEGRGLPPPPRRDWGDHGRREDDRSWQGTADGG 840
Query: 841 MMDRDHKRWQGGERSMSGHSGPGHMMNRGGMSGRGSFAPGGASRGHPIPHGGMQGGFGGQ 900
MMDRDHKRWQGGERSMSGHSGPGHMMNRGGMSGRGSFAPGGASRGHPIPHGGMQGGFGGQ
Sbjct: 841 MMDRDHKRWQGGERSMSGHSGPGHMMNRGGMSGRGSFAPGGASRGHPIPHGGMQGGFGGQ 900
Query: 901 SRGSRPSDARFTRRY 915
SRGSRPSDARFTRRY
Sbjct: 901 SRGSRPSDARFTRRY 915
>gi|7661936 scaffold attachment factor B2 [Homo sapiens]
Length = 953
Score = 1272 bits (3291), Expect = 0.0
Identities = 673/958 (70%), Positives = 774/958 (80%), Gaps = 48/958 (5%)
Query: 1 MAETLSGLGDSGAAGAAALSSASSETGTRRLSDLRVIDLRAELRKRNVDSSGNKSVLMER 60
MAETL G GDSG G A+L +ETGTRRLS+LRVIDLRAEL+KRN+D+ GNKSVLMER
Sbjct: 1 MAETLPGSGDSGP-GTASLGPGVAETGTRRLSELRVIDLRAELKKRNLDTGGNKSVLMER 59
Query: 61 LKKAIEDEGGNPDEIEITSEG-NKKTSKRSSKGRKPEEEGVEDNGLEENSGDGQEDVETS 119
LKKA+++EG +PDEI I E +KK++KR KG K EEEG EDNGLE++S DGQED+E S
Sbjct: 60 LKKAVKEEGQDPDEIGIELEATSKKSAKRCVKGLKMEEEGTEDNGLEDDSRDGQEDMEAS 119
Query: 120 LENLQDIDIMDISVLDEAEIDNGSVADCVEDDDADNLQESLSDSRELVEGEMKELPEQLQ 179
LENLQ++ +MD+SVLDE E+ N S D ED D L +S DS+E V ++++LP Q
Sbjct: 120 LENLQNMGMMDMSVLDETEVANSSAPDFGEDG-TDGLLDSFCDSKEYVAAQLRQLPAQPP 178
Query: 180 EHAIEDKETINNLDTSSSDFTILQEIEEPSLEPENEKILDILGETCKSEPVKEESSELEQ 239
EHA++ + N L+TSS +F + +IEE LEPENEKILDILGETCKSEPVKEESSELEQ
Sbjct: 179 EHAVDGEGFKNTLETSSLNFKVTPDIEESLLEPENEKILDILGETCKSEPVKEESSELEQ 238
Query: 240 PFAQDTSSVGPDRKLAEEEDLFDSAHPEEGDLDLASESTAHAQSSKADSLLAVVKREPAE 299
PFAQDTSSVGPDRKLAEEEDLFDSAHPEEGDLDLASESTAHAQSSKADSLLAVVKREPAE
Sbjct: 239 PFAQDTSSVGPDRKLAEEEDLFDSAHPEEGDLDLASESTAHAQSSKADSLLAVVKREPAE 298
Query: 300 QPGDGERTDCEPVGLEPAVEQSSAASELAEASSEELAEAPTEAPSPEARDSKEDGRKFDF 359
QPGDGERTDCEPVGLEPAVEQSSAASELAEASSEELAEAPTEAPSPEARDSKEDGRKFDF
Sbjct: 299 QPGDGERTDCEPVGLEPAVEQSSAASELAEASSEELAEAPTEAPSPEARDSKEDGRKFDF 358
Query: 360 DACNEVPPAPKESSTSEGADQKMSSPEDDSDTKRLSKEEKGR--SSCGRNFWVSGLSSTT 417
DACNEVPPAPKESSTSEGADQKMSS +++ D K + K+EKGR S GRN WVSGLSSTT
Sbjct: 359 DACNEVPPAPKESSTSEGADQKMSSFKEEKDIKPIIKDEKGRVGSGSGRNLWVSGLSSTT 418
Query: 418 RATDLKNLFSKYGKVVGAKVVTNARSPGARCYGFVTMSTAEEATKCINHLHKTELHGKMI 477
RATDLKNLFSKYGKVVGAKVVTNARSPGARCYGFVTMST++EATKCI+HLH+TELHG+MI
Sbjct: 419 RATDLKNLFSKYGKVVGAKVVTNARSPGARCYGFVTMSTSDEATKCISHLHRTELHGRMI 478
Query: 478 SVEKAKNEPVGKKTSDKRDSDGKKEKSSNSDR---------STNLKRDDKCDRKDDAKKG 528
SVEKAKNEP GKK SD+++ + KKEK S+ DR T +K+++K ++K++ K
Sbjct: 479 SVEKAKNEPAGKKLSDRKECEVKKEKLSSVDRHHSVEIKIEKTVIKKEEKIEKKEEKKPE 538
Query: 529 DDGSGEKSKDQDDQKPGPSERSRATKSGSRGTERTVVMDKSKGVPVISVK-TSGSKERAS 587
D ++ KDQD+ KPGP+ RSR TKSGSRG ERTVVMDKSKG PVISVK TS SKER+S
Sbjct: 539 D--IKKEEKDQDELKPGPTNRSRVTKSGSRGMERTVVMDKSKGEPVISVKTTSRSKERSS 596
Query: 588 KSQDRKSASREKRSVVSFDKVKEPR-----KSRDSE----SHSRVRERSEREQRMQAQWE 638
KSQDRKS S+EKR ++SFDK+KE R + R+ E R RE+ EREQR++A E
Sbjct: 597 KSQDRKSESKEKRDILSFDKIKEQRERERQRQREREIRETERRREREQREREQRLEAFHE 656
Query: 639 REERERLEIARERLAFQRQRLERERMERERLERERMHVEHERRREQERIHREREELRRQQ 698
R+E+ RL+ R +L QRQRLERERMERERLERERM VE ERR+EQERIHREREELRRQQ
Sbjct: 657 RKEKARLQRERLQLECQRQRLERERMERERLERERMRVERERRKEQERIHREREELRRQQ 716
Query: 699 E-LRYEQERRPAVRRPYDLDRRDDAYWPEAKRAALDERYHSDFNRQD-RFHDFDHRDRGR 756
E LRYEQERRP RRPYDLDRRDDAYWPE KR A+++RY +DF R D RFHDFDHRDRG+
Sbjct: 717 EQLRYEQERRPG-RRPYDLDRRDDAYWPEGKRVAMEDRYRADFPRPDHRFHDFDHRDRGQ 775
Query: 757 YPDHSVDRREGSRSMMGE-REGQHY-PERH---GGPERHGRDSRDGWGGYGSDKRMSEGR 811
Y DH++DRREGSR MMG+ R+GQHY +RH G PERHGRDSRDGWGGYGSDKR+SEGR
Sbjct: 776 YQDHAIDRREGSRPMMGDHRDGQHYGDDRHGHGGPPERHGRDSRDGWGGYGSDKRLSEGR 835
Query: 812 GLPPPPR--RDWGDHGRREDD---RSWQGTADGGMMDRDHKRWQGGERSMSGHSGPGHMM 866
GLPPPPR RDWG+H +R ++ R+WQG D G R+H RWQGGER +SG SGPGHM
Sbjct: 836 GLPPPPRGGRDWGEHNQRLEEHQARAWQGAMDAGAASREHARWQGGERGLSGPSGPGHMA 895
Query: 867 NRGGMSGRGSFAPGGASRGHPIPHGGMQ-GGFGGQSRGSR--------PSDARFTRRY 915
+RGG++GRG FA GG S+GH +P GG++ GG Q RGSR P FTRRY
Sbjct: 896 SRGGVAGRGGFAQGGHSQGHVVPGGGLEGGGVASQDRGSRVPHPHPHPPPYPHFTRRY 953
>gi|63176611 modulator of estrogen induced transcription isoform a
[Homo sapiens]
Length = 1034
Score = 425 bits (1092), Expect = e-118
Identities = 337/983 (34%), Positives = 495/983 (50%), Gaps = 163/983 (16%)
Query: 11 SGAAGAAALSSASSETGTRRLSDLRVIDLRAELRKRNVDSSGNKSVLMERLKKAIEDEGG 70
+ A GA A S+AS + ++++DLRVIDL++EL++RN+D +G K+VL+ RLK+AIE+EGG
Sbjct: 2 AAATGAVAASAASGQAEGKKITDLRVIDLKSELKRRNLDITGVKTVLISRLKQAIEEEGG 61
Query: 71 NPDEIEIT---SEGNKKTSKRSSKGRKPEEEGVEDNGLEENSGDGQEDVETSLENLQDID 127
+PD IE+T NKK +K KG+K E + E SGD + + +++ +
Sbjct: 62 DPDNIELTVSTDTPNKKPTK--GKGKKHEAD--------ELSGDASVEDDAFIKDCE--- 108
Query: 128 IMDISVLDEAEIDNGSVADCVEDDD--ADNLQESLSDSRELVEGEMKELPEQLQEHAIED 185
L+ E D ++D + +N +E++ L E K E ++ IED
Sbjct: 109 ------LENQEAHEQDGNDELKDSEEFGENEEENVHSKELLSAEENKRAHELIEAEGIED 162
Query: 186 --KETINNLDTSSSD-----FTILQEIEEPSLEPENEKILDILGETCKSEPVKEESSELE 238
KE I + + + + F Q+ EE ENEK DI G + + E+
Sbjct: 163 IEKEDIESQEIEAQEGEDDTFLTAQDGEEE----ENEK--DIAGSG-------DGTQEVS 209
Query: 239 QPFAQDTSSVGPDRKLAEEEDLFDSAHPEEGD---LDLASESTAHAQSSKADSLLAVVKR 295
+P + S D EE + + E D + + +E A D LL K
Sbjct: 210 KPLPSEGSLAEADHTAHEEMEAHTTVKEAEDDNISVTIQAED-AITLDFDGDDLLETGKN 268
Query: 296 -----EPAEQPGDGERTDCEPVGLEPAVEQSSAASELAEASSEELAEA-PTEAPSPEARD 349
A +P DG+ + E + +A + + E+ + P E + E+
Sbjct: 269 VKITDSEASKPKDGQDAIAQSPEKESKDYEMNANHK--DGKKEDCVKGDPVEKEARESSK 326
Query: 350 SKEDGRKFDFDACNEVPPAPKESSTSEGADQKMSSPEDDSDTKRLSKEEKGRSSCG---- 405
E G K E K S++ + Q SS ++ D+K SK++KG +S
Sbjct: 327 KAESGDK-------EKDTLKKGPSSTGASGQAKSSSKESKDSKTSSKDDKGSTSSTSGSS 379
Query: 406 ----RNFWVSGLSSTTRATDLKNLFSKYGKVVGAKVVTNARSPGARCYGFVTMSTAEEAT 461
+N WVSGLSS T+A DLKNLF KYGKV+ AKVVTNARSPGA+CYG VTMS++ E +
Sbjct: 380 GSSTKNIWVSGLSSNTKAADLKNLFGKYGKVLSAKVVTNARSPGAKCYGIVTMSSSTEVS 439
Query: 462 KCINHLHKTELHGKMISVEKAKNEP----VGKKTSDKRDSDGKKEKSSNSDRSTNLKRDD 517
+CI HLH+TELHG++ISVEK K +P + K+ +K S +K + SDRS+ +
Sbjct: 440 RCIAHLHRTELHGQLISVEKVKGDPSKKEMKKENDEKSSSRSSGDKKNTSDRSSKTQASV 499
Query: 518 KCDRKDDAKKGDDGSGEKSK--DQDDQKPGPSERSRATKSGSRGTERTVVMDKSKGVPVI 575
K + K ++K + + +K + D+K + ++S + E+ + KS G VI
Sbjct: 500 KKEEKRSSEKSEKKESKDTKKIEGKDEKNDNGASGQTSESIKKSEEKKRISSKSPGHMVI 559
Query: 576 SVKTSG-----------------SKERASKSQDRK-SASREKRSVVSFDKVKEPR----- 612
+T G SKE+ S D+K ++ ++ F+K+KE R
Sbjct: 560 LDQTKGDHCRPSRRGRYEKIHGRSKEKERASLDKKRDKDYRRKEILPFEKMKEQRLREHL 619
Query: 613 ----KSRDSESHSRVRERSERE----QRMQAQWEREERERLEIARERLAFQRQRLERERM 664
+ R + R RE +ERE +R++ EREERERL+ RERL +RQ+LERERM
Sbjct: 620 VRFERLRRAMELRRRREIAERERRERERIRIIREREERERLQRERERLEIERQKLERERM 679
Query: 665 ERERLERERMHVEHERRREQERIHREREELRR-QQELRYEQERRPAVRRPYDLD-RRDDA 722
ERERLERER+ +E ERR+E ERI REREELRR QQ+LRYEQE+R +++RP D+D RRDD
Sbjct: 680 ERERLERERIRIEQERRKEAERIAREREELRRQQQQLRYEQEKRNSLKRPRDVDHRRDDP 739
Query: 723 YWPEAKRAALDE----RYHSDFNR-QDRFHDFDHRDRGRYPDHSVDRR---EGSRSMMGE 774
YW E K+ +LD + SD++R Q+RF+DFDHR+RGR+P+ S + E +G+
Sbjct: 740 YWSENKKLSLDTDARFGHGSDYSRQQNRFNDFDHRERGRFPESSAVQSSSFERRDRFVGQ 799
Query: 775 REGQHYPERHGGPERHGRDSRDGWGGYGSDKRMSEGRGLPPPPRRDWGDHGRRE-----D 829
EG ++ R S + + SD R +E PPPPR + + RRE D
Sbjct: 800 SEG----KKARPTARREDPSFERYPKNFSDSRRNE----PPPPRNELRESDRREVRGERD 851
Query: 830 DR----------------------------SWQGTADGGMMDRDHKRWQGGERSMSGHSG 861
+R SW+ G M D + + SG
Sbjct: 852 ERRTVIIHDRPDITHPRHPREAGPNPSRPTSWKSE---GSMSTDKRETRVERPERSGREV 908
Query: 862 PGHMMNRGGMSGRGSFAPGGASR 884
GH + RG G S A G SR
Sbjct: 909 SGHSV-RGAPPGNRSSASGYGSR 930
Score = 48.9 bits (115), Expect = 2e-05
Identities = 66/243 (27%), Positives = 93/243 (38%), Gaps = 43/243 (17%)
Query: 596 SREKRSVVSFDKVKEPRKSRDSESHSRVRERSEREQRMQAQWEREERERLEIARERLAFQ 655
SR++ FD + R ES + ER R Q E + + R RE +F+
Sbjct: 762 SRQQNRFNDFD---HRERGRFPESSAVQSSSFERRDRFVGQSEGK-KARPTARREDPSFE 817
Query: 656 R--------QRLERERMERERLERERMHVEHERRREQERIHREREELRRQQELRYEQERR 707
R +R E E E +R V ER + I +R ++ R+ +E
Sbjct: 818 RYPKNFSDSRRNEPPPPRNELRESDRREVRGERDERRTVIIHDRPDITHP---RHPREAG 874
Query: 708 PAVRRPYDLDRRDDAYWPEAKRAALDERYHSDFNRQDRF--HDFDHRDRGRYPDH----- 760
P RP W + D+R + R +R H RG P +
Sbjct: 875 PNPSRPTS--------WKSEGSMSTDKR-ETRVERPERSGREVSGHSVRGAPPGNRSSAS 925
Query: 761 SVDRREGSRSMMGEREG--QHYPERHGGPERHGRDS---RDGWGG-------YGSDKRMS 808
REG R ++ +R G QHYPE ERHGRD+ R W G Y +RM
Sbjct: 926 GYGSREGDRGVITDRGGGSQHYPEERHVVERHGRDTSGPRKEWHGPPSQGPSYHDTRRMG 985
Query: 809 EGR 811
+GR
Sbjct: 986 DGR 988
>gi|62244004 modulator of estrogen induced transcription isoform b
[Homo sapiens]
Length = 1016
Score = 421 bits (1081), Expect = e-117
Identities = 339/986 (34%), Positives = 491/986 (49%), Gaps = 187/986 (18%)
Query: 11 SGAAGAAALSSASSETGTRRLSDLRVIDLRAELRKRNVDSSGNKSVLMERLKKAIEDEGG 70
+ A GA A S+AS + ++++DLRVIDL++EL++RN+D +G K+VL+ RLK+AIE+EGG
Sbjct: 2 AAATGAVAASAASGQAEGKKITDLRVIDLKSELKRRNLDITGVKTVLISRLKQAIEEEGG 61
Query: 71 NPDEIEIT---SEGNKKTSKRSSKGRKPEEEGVEDNGLEENSGDGQEDVETSLENLQDID 127
+PD IE+T NKK +K KG+K E + E SGD
Sbjct: 62 DPDNIELTVSTDTPNKKPTK--GKGKKHEAD--------ELSGDAS-------------- 97
Query: 128 IMDISVLDEAEIDNGSVADCVEDDDADNLQESLSDSRELVEGEMKELPEQLQEHAIEDKE 187
+ D + + + E++N + E D D L+ DS E E E E + KE
Sbjct: 98 VEDDAFIKDCELEN---QEAHEQDGNDELK----DSEEFGENE---------EENVHSKE 141
Query: 188 TINNLDTSSSDFTILQEIEEPSLEPENEKILDILGETCKSEPVKEESSELEQPFAQDTSS 247
++ + + I E E I DI E +S+ ++ + E DT
Sbjct: 142 LLSAEENKRAHELI-----------EAEGIEDIEKEDIESQEIEAQEGE------DDTFL 184
Query: 248 VGPDRKLAEEEDLFDSAHPEEGDLDLASESTAHAQSSKA--DSLLAVVKREPAEQPGDGE 305
D EEE+ E D E AH +A D++ ++ E A D +
Sbjct: 185 TAQD---GEEEENEKEGSLAEADHTAHEEMEAHTTVKEAEDDNISVTIQAEDAITL-DFD 240
Query: 306 RTDCEPVGLEPAVEQSSAASELAEASSEELAEAPT-EAPSPEARDSKEDGRKFDFDACNE 364
D G + S A+ + + +A++P E+ E + +DG+K D +
Sbjct: 241 GDDLLETGKNVKITDSEASKP--KDGQDAIAQSPEKESKDYEMNANHKDGKKEDCVKGDP 298
Query: 365 VPPAPKESS-----------------TSEGAD-QKMSSPEDDSDTKRLSKEEKGRSSCG- 405
V +ESS +S GA Q SS ++ D+K SK++KG +S
Sbjct: 299 VEKEARESSKKAESGDKEKDTLKKGPSSTGASGQAKSSSKESKDSKTSSKDDKGSTSSTS 358
Query: 406 -------RNFWVSGLSSTTRATDLKNLFSKYGKVVGAKVVTNARSPGARCYGFVTMSTAE 458
+N WVSGLSS T+A DLKNLF KYGKV+ AKVVTNARSPGA+CYG VTMS++
Sbjct: 359 GSSGSSTKNIWVSGLSSNTKAADLKNLFGKYGKVLSAKVVTNARSPGAKCYGIVTMSSST 418
Query: 459 EATKCINHLHKTELHGKMISVEKAKNEP----VGKKTSDKRDSDGKKEKSSNSDRSTNLK 514
E ++CI HLH+TELHG++ISVEK K +P + K+ +K S +K + SDRS+ +
Sbjct: 419 EVSRCIAHLHRTELHGQLISVEKVKGDPSKKEMKKENDEKSSSRSSGDKKNTSDRSSKTQ 478
Query: 515 RDDKCDRKDDAKKGDDGSGEKSK--DQDDQKPGPSERSRATKSGSRGTERTVVMDKSKGV 572
K + K ++K + + +K + D+K + ++S + E+ + KS G
Sbjct: 479 ASVKKEEKRSSEKSEKKESKDTKKIEGKDEKNDNGASGQTSESIKKSEEKKRISSKSPGH 538
Query: 573 PVISVKTSG-----------------SKERASKSQDRK-SASREKRSVVSFDKVKEPR-- 612
VI +T G SKE+ S D+K ++ ++ F+K+KE R
Sbjct: 539 MVILDQTKGDHCRPSRRGRYEKIHGRSKEKERASLDKKRDKDYRRKEILPFEKMKEQRLR 598
Query: 613 -------KSRDSESHSRVRERSERE----QRMQAQWEREERERLEIARERLAFQRQRLER 661
+ R + R RE +ERE +R++ EREERERL+ RERL +RQ+LER
Sbjct: 599 EHLVRFERLRRAMELRRRREIAERERRERERIRIIREREERERLQRERERLEIERQKLER 658
Query: 662 ERMERERLERERMHVEHERRREQERIHREREELRR-QQELRYEQERRPAVRRPYDLD-RR 719
ERMERERLERER+ +E ERR+E ERI REREELRR QQ+LRYEQE+R +++RP D+D RR
Sbjct: 659 ERMERERLERERIRIEQERRKEAERIAREREELRRQQQQLRYEQEKRNSLKRPRDVDHRR 718
Query: 720 DDAYWPEAKRAALDE----RYHSDFNR-QDRFHDFDHRDRGRYPDHSVDRR---EGSRSM 771
DD YW E K+ +LD + SD++R Q+RF+DFDHR+RGR+P+ S + E
Sbjct: 719 DDPYWSENKKLSLDTDARFGHGSDYSRQQNRFNDFDHRERGRFPESSAVQSSSFERRDRF 778
Query: 772 MGEREGQHYPERHGGPERHGRDSRDGWGGYGSDKRMSEGRGLPPPPRRDWGDHGRRE--- 828
+G+ EG ++ R S + + SD R +E PPPPR + + RRE
Sbjct: 779 VGQSEG----KKARPTARREDPSFERYPKNFSDSRRNE----PPPPRNELRESDRREVRG 830
Query: 829 --DDR----------------------------SWQGTADGGMMDRDHKRWQGGERSMSG 858
D+R SW+ G M D + + SG
Sbjct: 831 ERDERRTVIIHDRPDITHPRHPREAGPNPSRPTSWKSE---GSMSTDKRETRVERPERSG 887
Query: 859 HSGPGHMMNRGGMSGRGSFAPGGASR 884
GH + RG G S A G SR
Sbjct: 888 REVSGHSV-RGAPPGNRSSASGYGSR 912
Score = 48.9 bits (115), Expect = 2e-05
Identities = 66/243 (27%), Positives = 93/243 (38%), Gaps = 43/243 (17%)
Query: 596 SREKRSVVSFDKVKEPRKSRDSESHSRVRERSEREQRMQAQWEREERERLEIARERLAFQ 655
SR++ FD + R ES + ER R Q E + + R RE +F+
Sbjct: 744 SRQQNRFNDFD---HRERGRFPESSAVQSSSFERRDRFVGQSEGK-KARPTARREDPSFE 799
Query: 656 R--------QRLERERMERERLERERMHVEHERRREQERIHREREELRRQQELRYEQERR 707
R +R E E E +R V ER + I +R ++ R+ +E
Sbjct: 800 RYPKNFSDSRRNEPPPPRNELRESDRREVRGERDERRTVIIHDRPDITHP---RHPREAG 856
Query: 708 PAVRRPYDLDRRDDAYWPEAKRAALDERYHSDFNRQDRF--HDFDHRDRGRYPDH----- 760
P RP W + D+R + R +R H RG P +
Sbjct: 857 PNPSRPTS--------WKSEGSMSTDKR-ETRVERPERSGREVSGHSVRGAPPGNRSSAS 907
Query: 761 SVDRREGSRSMMGEREG--QHYPERHGGPERHGRDS---RDGWGG-------YGSDKRMS 808
REG R ++ +R G QHYPE ERHGRD+ R W G Y +RM
Sbjct: 908 GYGSREGDRGVITDRGGGSQHYPEERHVVERHGRDTSGPRKEWHGPPSQGPSYHDTRRMG 967
Query: 809 EGR 811
+GR
Sbjct: 968 DGR 970
>gi|239747134 PREDICTED: hypothetical protein XP_002343921 [Homo
sapiens]
Length = 600
Score = 100 bits (250), Expect = 5e-21
Identities = 107/449 (23%), Positives = 185/449 (41%), Gaps = 38/449 (8%)
Query: 494 KRDSDGKKEKSSNSDRSTNLKRDDKCDRKDDAKKGDDGSGEKSKDQ--------DDQKPG 545
+R D +KE+ +DR + +R+ + +R+ + ++ + GE+ +D+ + Q+
Sbjct: 96 ERQRDREKERERQTDRERDRQREKERNRQKERERETEREGERGRDRQTDGQRERERQRDA 155
Query: 546 PSERSRAT-KSGSRGTERTVVMDKSKGVPVISVKT-SGSKERASKSQDRKSA-----SRE 598
ER R T + R TER ++ + + +E+ +K++DR S RE
Sbjct: 156 EKERERQTDRERQRQTERNRQKEREREKNRQERRERERQREKENKTEDRHSERGRERERE 215
Query: 599 KRSVVSFDKVKEPRKSRDSESHS-RVRER-SEREQRMQAQWEREERERLEIARERLAFQR 656
+ + ++ ++ + RD + + R RE+ +ERE+ + + ER++ E R+R +R
Sbjct: 216 RETETETERKRQTDRERDRQRKTEREREKQAERERASERETERDKERERERDRDRDRDRR 275
Query: 657 QRLERERMERERLERERMHVEHERRREQERIHREREELRRQQELRYEQERRPAVRRPYDL 716
Q+ + +R+R R E ER+RE++R E R++E E+ER +R +
Sbjct: 276 QKERERQTDRKRQRRTERDRETERKRERQRERERERERNRKRERERERERERERQRETER 335
Query: 717 DRRDDAYWPEAKRAALDERYHSDFNRQDRFHDFDHRDRGRYPDHSVDRREGSRSMMGERE 776
DR + ++ +D + R+ R R+R R D R R +R+
Sbjct: 336 DREKERERKRKRQTEMDRERNRQTGREGRRQAERERERERERDRQSAREREERERDRDRD 395
Query: 777 GQHYPERHGGPERHGRDSRDGWGGYGSDKRMSEGRGLPPPPRRDWGDHGRREDDRSWQG- 835
Q ER +R G+ + D+ GR + G RE Q
Sbjct: 396 RQKERERQTEKDRDGQRETEKQREREKDRESERGRERGREREKQKGRERDRERQTDRQAG 455
Query: 836 ---------------TADGGMMDRDHKRWQGGERSMSGHSGPGHMMNRGGMSGRGSFAPG 880
TA G++ D R G R S P R GR + A
Sbjct: 456 RQRKRSTLYVNPPPRTARSGVVQSDPNRPTRGIRWKSSPEDPKAASTRFPW-GRPAKASR 514
Query: 881 G--ASRGHPIPHGGMQGGFGGQSRGSRPS 907
G A R P G + G GG+ G RPS
Sbjct: 515 GRVAGRRRWEPRLGEKRGQGGE--GRRPS 541
Score = 80.9 bits (198), Expect = 5e-15
Identities = 93/377 (24%), Positives = 160/377 (42%), Gaps = 24/377 (6%)
Query: 468 HKTELHGKMISVEKAKNEPVGKKTSDKRDSDGKKEKSSNSDRSTNLKRDDKCDRKDDAKK 527
+KTE E+ + +T KR +D ++++ R T +R+ + +R+ +++
Sbjct: 199 NKTEDRHSERGRERERERETETETERKRQTDRERDR----QRKTEREREKQAERERASER 254
Query: 528 GDDGSGEKSKDQD---DQKPGPSERSRAT-KSGSRGTERTVVMDKSKGVPVISVKTSGSK 583
+ E+ +++D D+ ER R T + R TER ++ + +
Sbjct: 255 ETERDKERERERDRDRDRDRRQKERERQTDRKRQRRTERDRETERKRERQRERERERERN 314
Query: 584 ERASKSQDR-KSASREKRSVVSFDKVKEPRKSRDSESHSRVRERSEREQRMQAQWERE-E 641
+ + ++R + R++ + +K +E ++ R +E ++ RE R QA+ ERE E
Sbjct: 315 RKRERERERERERERQRETERDREKERERKRKRQTEMDRERNRQTGREGRRQAERERERE 374
Query: 642 RER-LEIARERLAFQRQRLERERMERER-LERER---MHVEHERRREQERIH---REREE 693
RER + ARER +R R + ERER E++R E +R RE++R RER
Sbjct: 375 RERDRQSAREREERERDRDRDRQKERERQTEKDRDGQRETEKQREREKDRESERGRERGR 434
Query: 694 LRRQQELRYEQERRPAVRRPYDLDRRDDAYWPEAKRAALDERYHSDFNRQDRFHDFDHRD 753
R +Q+ R R R+ +R Y R A SD NR R +
Sbjct: 435 EREKQKGRERDRERQTDRQAGRQRKRSTLYVNPPPRTARSGVVQSDPNRPTR--GIRWKS 492
Query: 754 RGRYPDHSVDRREGSRSMMGER----EGQHYPERHGGPERHGRDSRDGWGGYGSDKRMSE 809
P + R R R + + R G G + R GG+G++ +S+
Sbjct: 493 SPEDPKAASTRFPWGRPAKASRGRVAGRRRWEPRLGEKRGQGGEGRRPSGGFGTENPLSQ 552
Query: 810 GRGLPPPPRRDWGDHGR 826
+ P PR GD R
Sbjct: 553 APSVFPGPRYTPGDGKR 569
Score = 70.5 bits (171), Expect = 7e-12
Identities = 81/336 (24%), Positives = 128/336 (38%), Gaps = 29/336 (8%)
Query: 531 GSGEKSKDQDDQKPGPS---ERSRATKSGSRGTERTVVMDKSKGVPVISVKTSGSKERAS 587
G K D DD++ ER R + R T+R + K ++R
Sbjct: 43 GQAHKDADGDDRERNRQKERERRREKRQTERETDRKRERRREKD-------RHRKRDRHR 95
Query: 588 KSQDRKSASREKRSVVSFDKVKEPRKSRDSESHSRVRERSEREQRMQAQWEREERERLEI 647
+ Q + RE+++ D+ +E ++R E ER + Q +RE + +
Sbjct: 96 ERQRDREKERERQTDRERDRQREKERNRQKERERETEREGERGRDRQTDGQRERERQRDA 155
Query: 648 ARERLAFQRQRLERERMERERLERERMHVEHERR-REQER--------IHRER-EELRRQ 697
+ER + +R+ + ERER ERR RE++R H ER E R+
Sbjct: 156 EKERERQTDRERQRQTERNRQKEREREKNRQERRERERQREKENKTEDRHSERGRERERE 215
Query: 698 QELRYEQERRPAVRRPYDLDRRDDAYWPEAKRAALDERYHSDFNRQDRFHDFDHRDRGRY 757
+E E ER+ R D R+ + E ++ A ER +D+ R+R R
Sbjct: 216 RETETETERKRQTDRERDRQRKTER---EREKQAERERASERETERDK-----ERERERD 267
Query: 758 PDHSVDRREGSRSMMGEREGQHYPERHGGPERHGRDSRDGWGGYGSDKRMSEGRGLPPPP 817
D DRR+ R +R+ Q ER ER R+ +++ R
Sbjct: 268 RDRDRDRRQKERERQTDRKRQRRTERDRETERKRERQRERERERERNRKRERERERERER 327
Query: 818 RRDWGDHGRREDDRSWQGTADGGMMDRDHKRWQGGE 853
R RE +R + MDR+ R G E
Sbjct: 328 ERQRETERDREKERERKRKRQ-TEMDRERNRQTGRE 362
Score = 55.1 bits (131), Expect = 3e-07
Identities = 74/306 (24%), Positives = 115/306 (37%), Gaps = 25/306 (8%)
Query: 552 ATKSGSRGTERTVVMDKSKGVPVISVKTSGSKERASKSQDRKSASREKRSVVSFDKVKEP 611
A + G+ E T+ +D S+ P GS+E S R+ + + D+ +
Sbjct: 10 ADQLGTLWVEVTIPLDFSRRRP-------GSQE----SPRRRGLGQAHKDADGDDRERNR 58
Query: 612 RKSRDSESHSRVRERS---EREQRMQAQWEREERERLEIARERLAFQRQRLERERMERER 668
+K R+ R ER +RE+R + R+ E R+R + ++ +RER +
Sbjct: 59 QKERERRREKRQTERETDRKRERRREKDRHRKRDRHRERQRDREKERERQTDRERDRQRE 118
Query: 669 LERERMHVEHERRREQERIHREREELRRQQELRYEQERRPAVRRPYDLDRRDDAYWPEAK 728
ER R + ER RE ER ER R+ R + +R A + R+ E
Sbjct: 119 KERNR---QKERERETER-EGERGRDRQTDGQRERERQRDAEKERERQTDRERQRQTERN 174
Query: 729 RAALDERYHSDFNRQDRFHDFDHRDRGRYPDHSVDRREGSRSMMGEREGQHYPERHGGPE 788
R ER + NRQ+R R+R R ++ + R R ERE + E +
Sbjct: 175 RQKERER---EKNRQER----RERERQREKENKTEDRHSERGRERERERETETETERKRQ 227
Query: 789 RHGRDSRDGWGGYGSDKRMSEGRGLPPPPRRDWGDHGRREDDRSWQGTADGGMMDRDHKR 848
R +K+ R RD R+ DR D KR
Sbjct: 228 TDRERDRQRKTEREREKQAERERASERETERDKERERERDRDRDRDRRQKERERQTDRKR 287
Query: 849 WQGGER 854
+ ER
Sbjct: 288 QRRTER 293
>gi|89001107 dentin sialophosphoprotein preproprotein [Homo sapiens]
Length = 1301
Score = 82.8 bits (203), Expect = 1e-15
Identities = 116/636 (18%), Positives = 233/636 (36%), Gaps = 41/636 (6%)
Query: 6 SGLGDSGAAGAAALSSASSETGTRRLSDLRVIDLRAELRKRNVDSSGNKSVLMERLKKAI 65
SG G S ++ + + S +S+ + + SD D + + DS + S + +
Sbjct: 542 SGKGKSDSSDSDS-SDSSNSSDSSDSSDSDSSDSNSSSDSDSSDSDSSDSSDSDSSDSSN 600
Query: 66 EDEGGNPDEIEITSEGNKKTSKRSSKGRKPEEEGVEDN---GLEENSGDGQEDVETS--- 119
+ + + +S+ + + +S + + D+ + NS D ++ ++S
Sbjct: 601 SSDSSDSSDSSDSSDSSDSSDSKSDSSKSESDSSDSDSKSDSSDSNSSDSSDNSDSSDSS 660
Query: 120 -LENLQDIDIMDISVLDEAEIDNGSVADCVEDDDADNLQESLSDSRELVEGEMKELPEQL 178
N D S + D+ + +D + D+ N ES SDS + + + + +
Sbjct: 661 NSSNSSDSSDSSDSSDSSSSSDSSNSSDSSDSSDSSNSSES-SDSSDSSDSDSSDSSDSS 719
Query: 179 QEHAIEDKETINNLDTSSSDFTILQEIEEPSLEPENEKILDILGETCKSEPVKEESSELE 238
++ D ++ N+ D+S S + S + + ++ S + S +
Sbjct: 720 NSNS-SDSDSSNSSDSSDSSNS------SDSSDSSDSSNSSDSSDSSDSSNSSDSSDSSD 772
Query: 239 QPFAQDTSSVGPDRKLAEEEDLFDSAHPEEGDLDLASESTAHAQSSKADSLLAVVKREPA 298
+ D+S+ + D DS++ D +S+S+ + SS +DS + +
Sbjct: 773 SSDSSDSSNSSDSNDSSNSSDSSDSSN--SSDSSNSSDSSDSSDSSDSDSSNSSDSSNSS 830
Query: 299 EQPGDGERTDCEPVGLEPAVEQSSAASELAEASSEELAEAPTEAPSPEARDSKEDGRKFD 358
+ +D SS +S+ +++ S +++ + S ++ DS D
Sbjct: 831 DSSDSSNSSDSS---------DSSDSSDGSDSDSSNRSDSSNSSDSSDSSDSSNSSDSSD 881
Query: 359 FDACNEVPPAPKESSTSEGADQKMSSPEDDSDTKRLSKEEKGRSSCGRNFWVSGLSSTTR 418
NE S++S+ +D SS D SD+ S + S+ + S S +
Sbjct: 882 SSDSNE------SSNSSDSSDSSNSSDSDSSDSSN-SSDSSDSSNSSDSSESSNSSDNSN 934
Query: 419 ATDLKNLFSKYGKVVGAKVVTNARSPGARCYGFVTMSTAEEATKCINHLHKTELHGKMIS 478
++D N + ++ S + + S + +++ N ++ S
Sbjct: 935 SSDSSNSSDSSDSSDSSNSSDSSNSSDSSNSSDSSDSNSSDSSDSSNSSDSSDSSDSSDS 994
Query: 479 VEKA--KNEPVGKKTSDKRDSDGKKEKSSNSDRSTNLKRDDKCDRKDDAKKGDDG----S 532
+ + N +SD DS + S++SD S + D D D + D S
Sbjct: 995 SDSSDSSNSSDSSDSSDSSDSSNSSDSSNSSDSSNSSDSSDSSDSSDSSDSSDSSDSSDS 1054
Query: 533 GEKSKDQDDQKPGPSERSRATKSGSRGTERTVVMDKSKGVPVISVKTSGSKERASKSQDR 592
S D S S + S +E + D S S +S S D
Sbjct: 1055 SNSSDSSDSSDSSDSSDSSDSSDSSDSSESSDSSDSSNSSDSSDSSDSSDSSDSSDSSDS 1114
Query: 593 KSASREKRSVVSFDKVKEPRKSRDSESHSRVRERSE 628
+S S S D + S DS + S + SE
Sbjct: 1115 SDSSDSSNSSDSSDS-SDSSDSSDSSNSSDSSDSSE 1149
Score = 78.2 bits (191), Expect = 3e-14
Identities = 104/566 (18%), Positives = 201/566 (35%), Gaps = 51/566 (9%)
Query: 67 DEGGNPDEIEITSEGNKKT---SKRSSKGRKPEEEGVEDNGLEENSGDGQEDVETSLENL 123
DE D+ S+ N + + +S K G + G E++ D D S N
Sbjct: 469 DESNGNDDANSESDNNSSSRGDASYNSDESKDNGNGSDSKGAEDDDSDSTSDTNNSDSNG 528
Query: 124 QDIDIMDISVLDEAEIDNGSVADCVEDDDADNLQESLSDSRELVEGEMKELPEQLQEHAI 183
+ D D + D+G D D+ + S SDS + + + + +
Sbjct: 529 NGNNGND----DNDKSDSGKGKSDSSDSDSSDSSNS-SDSSDSSDSDSSDSNSSSDSDS- 582
Query: 184 EDKETINNLDTSSSDFTILQEIEEPSLEPENEKILDILGETCKSEPVKEESSELEQPFAQ 243
D ++ ++ D+ SSD + + + S ++ D KS+ K ES +
Sbjct: 583 SDSDSSDSSDSDSSDSSNSSDSSDSSDSSDSSDSSD--SSDSKSDSSKSESDSSDSDSKS 640
Query: 244 DTSSVGPDRKLAEEEDLFDSAHPEEGDLDLASESTAHAQSSKADSLLAVVKREPAEQPGD 303
D+S ++ D DS++ D + S + SS +DS + + ++
Sbjct: 641 DSSDSNSSDS-SDNSDSSDSSNSSNSS-DSSDSSDSSDSSSSSDSSNSSDSSDSSDSSNS 698
Query: 304 GERTDCEPVGLEPAVEQS-SAASELAEASSEELAEAPTEAPSPEARDSKEDGRKFDFDAC 362
E +D + + S S+ S +++ S +++ + S ++ DS + D
Sbjct: 699 SESSDSSDSSDSDSSDSSDSSNSNSSDSDSSNSSDSSDSSNSSDSSDSSDSSNSSDSSDS 758
Query: 363 NEVPPAPKESSTSEGADQKMSSPEDDSDTKRLSKEEKGRSSCGRNFWVSGLSSTTRATDL 422
++ + S +S+ +D SS DS+ S + S+ + S S ++ ++D
Sbjct: 759 SDSSNSSDSSDSSDSSDSSDSSNSSDSNDSSNSSDSSDSSNSSDSSNSSDSSDSSDSSDS 818
Query: 423 KNLFSKYGKVVGAKVVTNARSPGARCYGFVTMSTAEEATKCINHLHKTELHGKMISVEKA 482
+ S S + +++ N ++
Sbjct: 819 DSSNSS------------------------DSSNSSDSSDSSNSSDSSD--------SSD 846
Query: 483 KNEPVGKKTSDKRDSDGKKEKSSNSDRSTNLKRDDKCDRKDDAKKGDDGSGEKSKDQDDQ 542
++ +S++ DS + S +SD S + D D + + D S D D
Sbjct: 847 SSDGSDSDSSNRSDSSNSSDSSDSSDSSNSSDSSDSSDSNESSNSSDSSDSSNSSDSDSS 906
Query: 543 KPGPSERSRATKSGSRGTERTVVMDKSKGVPVISVKTSGSKERASKSQDRKSASREKRSV 602
S S + + S +E + D S + S +S S D ++S S
Sbjct: 907 DSSNSSDSSDSSNSSDSSESSNSSDNSNSSDSSNSSDSSDSSDSSNSSDSSNSSDSSNSS 966
Query: 603 VSFDKVKEPRKSRDSESHSRVRERSE 628
S D S DS S + S+
Sbjct: 967 DSSDS-----NSSDSSDSSNSSDSSD 987
Score = 73.6 bits (179), Expect = 8e-13
Identities = 106/601 (17%), Positives = 211/601 (35%), Gaps = 37/601 (6%)
Query: 49 DSSGNKSVLMERLKKAIE--DEGGNPDEIEITSEGNKK------TSKRSSKGRKPEEEGV 100
+S+GN E + D N DE + G+ S +S + G
Sbjct: 470 ESNGNDDANSESDNNSSSRGDASYNSDESKDNGNGSDSKGAEDDDSDSTSDTNNSDSNGN 529
Query: 101 EDNGLEEN----SGDGQEDV--ETSLENLQDIDIMDISVLDEAEIDNGSVADCVEDDDAD 154
+NG ++N SG G+ D S ++ D D S D ++ ++ S +D + D +D
Sbjct: 530 GNNGNDDNDKSDSGKGKSDSSDSDSSDSSNSSDSSDSSDSDSSDSNSSSDSDSSDSDSSD 589
Query: 155 NLQESLSDSRELVE----GEMKELPEQLQEHAIEDKETINNLDTSSSDFTILQEIEEPSL 210
+ SDS + + + + + + + D+S SD S
Sbjct: 590 SSDSDSSDSSNSSDSSDSSDSSDSSDSSDSSDSKSDSSKSESDSSDSDSKSDSSDSNSSD 649
Query: 211 EPENEKILDI-----LGETCKSEPVKEESSELEQPFAQDTSSVGPDRKLAEEEDLFDSAH 265
+N D ++ S + SS + + D+S +E D DS+
Sbjct: 650 SSDNSDSSDSSNSSNSSDSSDSSDSSDSSSSSDSSNSSDSSDSSDSSNSSESSDSSDSSD 709
Query: 266 PEEGDLDLASESTAHAQSSKADSLLAVVKREPAEQPGDGERTDCEPVGLEPAVEQSSAAS 325
+ D S ++++ SS +DS + + + + +D + + S +++
Sbjct: 710 SDSSD----SSDSSNSNSSDSDSSNSSDSSDSSNSSDSSDSSDSS--NSSDSSDSSDSSN 763
Query: 326 ELAEASSEELAEAPTEAPSPEARDSKEDGRKFDFDACNEVPPAPKESSTSEGADQKMSSP 385
+ S + +++ + S ++ DS D ++ + S +S+ +D S+
Sbjct: 764 SSDSSDSSDSSDSSDSSNSSDSNDSSNSSDSSDSSNSSDSSNSSDSSDSSDSSDSDSSNS 823
Query: 386 EDDSDTKRLS-------KEEKGRSSCGRNFWVSGLSSTTRATDLKNLFSKYGKVVGAKVV 438
D S++ S + SS G + S S ++ ++D + +
Sbjct: 824 SDSSNSSDSSDSSNSSDSSDSSDSSDGSDSDSSNRSDSSNSSDSSDSSDSSNSSDSSDSS 883
Query: 439 TNARSPGARCYGFVTMSTAEEATKCINHLHKTELHGKMISVEKAKNEPVGKKTSDKRDSD 498
+ S + + S+ +++ N ++ S E + N +SD +S
Sbjct: 884 DSNESSNSSDSSDSSNSSDSDSSDSSNSSDSSDSSNSSDSSE-SSNSSDNSNSSDSSNSS 942
Query: 499 GKKEKSSNSDRSTNLKRDDKCDRKDDAKKGDDGSGEKSKDQDDQKPGPSERSRATKSGSR 558
+ S +S+ S + D + D + S + S D S S + S
Sbjct: 943 DSSDSSDSSNSSDSSNSSDSSNSSDSSDSNSSDSSDSSNSSDSSDSSDSSDSSDSSDSSN 1002
Query: 559 GTERTVVMDKSKGVPVISVKTSGSKERASKSQDRKSASREKRSVVSFDKVKEPRKSRDSE 618
++ + D S S +S S D +S S S D S S+
Sbjct: 1003 SSDSSDSSDSSDSSNSSDSSNSSDSSNSSDSSDSSDSSDSSDSSDSSDSSDSSNSSDSSD 1062
Query: 619 S 619
S
Sbjct: 1063 S 1063
Score = 72.0 bits (175), Expect = 2e-12
Identities = 109/625 (17%), Positives = 213/625 (34%), Gaps = 48/625 (7%)
Query: 6 SGLGDSGAAGAAALSSASSETGTRRLSDLRVIDLRAELRKRNVDSSGNKSVLMERLKKAI 65
S DS + ++ SS SS++ + SD + + DSS + +
Sbjct: 690 SDSSDSSNSSESSDSSDSSDSDSSDSSDSSNSNSSDSDSSNSSDSSDSSN---SSDSSDS 746
Query: 66 EDEGGNPDEIEITSEGNKKTSKRSSKGRKPEEEGVEDNGLEENSGDGQEDVETSLENLQD 125
D + D + + N S SS + + + ++ D S ++
Sbjct: 747 SDSSNSSDSSDSSDSSNSSDSSDSSDSSDSSDSSNSSDSNDSSNSSDSSDSSNSSDSSNS 806
Query: 126 IDIMDISVLDEAEIDNGSVADCVEDDDADNLQESLSDSRELVEGEMKELPEQLQEHAIED 185
D D S +++ N S + D + SDS + +G + + D
Sbjct: 807 SDSSDSSDSSDSDSSNSSDSSNSSDSSDSSNSSDSSDSSDSSDGSDSDSSNRSDSSNSSD 866
Query: 186 K----ETINNLDTSSSDFTILQEIEEPSLEPENEKILDILGETCKSEPVKEESSE--LEQ 239
++ N+ D+S S + S + N D + S+ +S E
Sbjct: 867 SSDSSDSSNSSDSSDSSDSNESSNSSDSSDSSNSSDSDSSDSSNSSDSSDSSNSSDSSES 926
Query: 240 PFAQDTSSVGPDRKLAEEEDLFDSAHPEEGDLDLASESTAHAQSSKADSLLAVVKREPAE 299
+ D S+ ++ D DS++ D +S+S+ + SS ++S + ++
Sbjct: 927 SNSSDNSNSSDSSNSSDSSDSSDSSN--SSDSSNSSDSSNSSDSSDSNSSDSSDSSNSSD 984
Query: 300 QPGDGERTDCEPVGLEPAVEQSSAASELAEAS-SEELAEAPTEAPSPEARDSKEDGRKFD 358
+ +D SS +S+ +++S S + + + + S ++ DS + D
Sbjct: 985 SSDSSDSSDSSDSSDSSNSSDSSDSSDSSDSSNSSDSSNSSDSSNSSDSSDSSDSSDSSD 1044
Query: 359 FDACNEVPPAPKESSTSEGADQKMSSPEDDSDTKRLSKEEKGRSSCGRNFWVSGLSSTTR 418
++ + S +S+ +D SS DS S E S + S S ++
Sbjct: 1045 SSDSSDSSDSSNSSDSSDSSDSSDSSDSSDSSDSSDSSESSDSSDSSNSSDSSDSSDSSD 1104
Query: 419 ATDLKNLFSKYGKVVGAKVVTNARSPGARCYGFVTMSTAEEATKCINHLHKTELHGKMIS 478
++D + S + +++ N ++ S
Sbjct: 1105 SSDSSD-----------------------------SSDSSDSSDSSNSSDSSDSSDSSDS 1135
Query: 479 VEKAKNEPVG--KKTSDKRDSDGKKEKSSNSDRSTNLKRDDKCDRKDDAKKGDDGSGEKS 536
+ + + ++SD DS + S +SD S + D + D + D S
Sbjct: 1136 SDSSNSSDSSDSSESSDSSDSSDSSDSSDSSDSSDSSDSSDSSNSSDSSDSSDSSDSSDS 1195
Query: 537 KDQDDQKPGPSERSRATKSGSRGTERTVVMDKSKGVPVISVKTSGSKERASKSQDRKSAS 596
D D S S + S ++ + D S S +S S D ++S
Sbjct: 1196 SDSSD-----SSDSSDSSDSSDSSDSSDSSDSSDSSDSSDSNESSDSSDSSDSSDSSNSS 1250
Query: 597 REKRSVVSFDKVKEPRKSRDSESHS 621
S S D + DS+S S
Sbjct: 1251 DSSDSSDSSDSTSDSNDESDSQSKS 1275
Score = 71.6 bits (174), Expect = 3e-12
Identities = 104/602 (17%), Positives = 207/602 (34%), Gaps = 42/602 (6%)
Query: 47 NVDSSGNKSVLMERLK---KAIEDEGGNPDEIEITSEGNKKTSK-----------RSSKG 92
N S G+ S + K + +G D+ + TS+ N S +S G
Sbjct: 484 NSSSRGDASYNSDESKDNGNGSDSKGAEDDDSDSTSDTNNSDSNGNGNNGNDDNDKSDSG 543
Query: 93 RKPEEEGVEDNGLEENSGDGQEDVETSLENLQDIDIMDISVLDEAEIDNGSVADCVEDDD 152
+ + D+ NS D + ++ + D S D ++ + +D D
Sbjct: 544 KGKSDSSDSDSSDSSNSSDSSDSSDSDSSDSNSSSDSDSSDSDSSDSSDSDSSDSSNSSD 603
Query: 153 ADNLQESLSDSRELVEGEMKELPEQLQEHAIEDKETINNLDTSSSDFTILQEIEEPSLEP 212
+ + +S S + K + + + + ++ D++SSD + + + S
Sbjct: 604 SSDSSDSSDSSDSSDSSDSKSDSSKSESDSSDSDSKSDSSDSNSSDSSDNSDSSDSSNSS 663
Query: 213 ENEKILDILGETCKSEPVKEESSELEQPFAQDTSSVGPDRKLAEEEDLFDSAHPEEGDLD 272
+ D S + SS + + D+S +E D DS+ + D
Sbjct: 664 NSSDSSD-------SSDSSDSSSSSDSSNSSDSSDSSDSSNSSESSDSSDSSDSDSSD-- 714
Query: 273 LASESTAHAQSSKADSLLAVVKREPAEQPGDGERTDCEPVGLEPAVEQSSAASELAEASS 332
S ++++ SS +DS + + + + +D SS +S+ +++S
Sbjct: 715 --SSDSSNSNSSDSDSSNSSDSSDSSNSSDSSDSSDSSNSSDSSDSSDSSNSSDSSDSSD 772
Query: 333 EELAEAPTEAPSPEARDSKEDGRKFDFDACNEVPPAPKESSTSEGADQKMSSPEDDSDTK 392
+++ + S ++ DS D ++ + S +S+ +D S+ D S++
Sbjct: 773 S--SDSSDSSNSSDSNDSSNSSDSSDSSNSSDSSNSSDSSDSSDSSDSDSSNSSDSSNSS 830
Query: 393 RLS-------KEEKGRSSCGRNFWVSGLSSTTRATDLKNLFSKYGKVVGAKVVTNARSPG 445
S + SS G + S S ++ ++D + + + S
Sbjct: 831 DSSDSSNSSDSSDSSDSSDGSDSDSSNRSDSSNSSDSSDSSDSSNSSDSSDSSDSNESSN 890
Query: 446 ARCYGFVTMSTAEEATKCINHLHKTELHGKMISVEKAK-----NEPVGKKTSDKRDSDGK 500
+ + S+ +++ N ++ S E + N +SD DS
Sbjct: 891 SSDSSDSSNSSDSDSSDSSNSSDSSDSSNSSDSSESSNSSDNSNSSDSSNSSDSSDSSDS 950
Query: 501 KEKS--SNSDRSTNLKRDDKCDRKDDAKKGDDGSGEKSKDQDDQK-PGPSERSRATKSGS 557
S SNS S+N + D + + S D D S S + S
Sbjct: 951 SNSSDSSNSSDSSNSSDSSDSNSSDSSDSSNSSDSSDSSDSSDSSDSSDSSNSSDSSDSS 1010
Query: 558 RGTERTVVMDKSKGVPVISVKTSGSKERASKSQDRKSASREKRSVVSFDKVKEPRKSRDS 617
++ + D S + S +S S D +S S S D S S
Sbjct: 1011 DSSDSSNSSDSSNSSDSSNSSDSSDSSDSSDSSDSSDSSDSSDSSNSSDSSDSSDSSDSS 1070
Query: 618 ES 619
+S
Sbjct: 1071 DS 1072
Score = 69.7 bits (169), Expect = 1e-11
Identities = 123/592 (20%), Positives = 226/592 (38%), Gaps = 61/592 (10%)
Query: 66 EDEGGNPDEIEITSEGNKKTSKRSSKGRKPEEEGVE---DNGLEENSG-------DGQED 115
EDEG DE E GN K S +SKG++ ++ G E D+ + +NS +G+ED
Sbjct: 255 EDEGSGDDEDE--EAGNGKDSSNNSKGQEGQDHGKEDDHDSSIGQNSDSKEYYDPEGKED 312
Query: 116 VETSLENLQDIDIMDISVLDEAEIDNGSVADCVEDDDADNLQESLSDSRELVEGEMKELP 175
N D D S + A I + + +ED N +ES + +
Sbjct: 313 P----HNEVDGDKTSKSEENSAGIPEDNGSQRIEDTQKLNHRESKRVENRITKESETHAV 368
Query: 176 EQLQEHAIEDKETINNLDTSSSDFTILQEIEEPSLEPENE----------------KILD 219
+ Q+ IE K SS + I +E+ + + E++ ++++
Sbjct: 369 GKSQDKGIEIK------GPSSGNRNITKEVGKGNEGKEDKGQHGMILGKGNVKTQGEVVN 422
Query: 220 ILGETCKSEPVKE--ESSELEQPFAQDTSSVGPDRKLAEEEDLFDSAHPEEGDLDLASES 277
I G KSEP + S+ + S D K + +D +S+ G+ D SES
Sbjct: 423 IEGPGQKSEPGNKVGHSNTGSDSNSDGYDSYDFDDKSMQGDDP-NSSDESNGNDDANSES 481
Query: 278 TAHAQSSKADSLLAVVKREPAEQPGDGERTDCEPVGLEPAVEQSSAASELAEASSEELAE 337
++ SS+ D A + ++ G+G + G E S++ + ++++
Sbjct: 482 DNNS-SSRGD---ASYNSDESKDNGNGS----DSKGAEDDDSDSTSDTNNSDSNGNGNNG 533
Query: 338 APTEAPSPEARDSKEDGRKFDFDACNEVPPAPKESSTSEGADQKMSSPEDDSDTKRLSKE 397
S + + D+ N + +SS S+ +D SS D SD+
Sbjct: 534 NDDNDKSDSGKGKSDSSDSDSSDSSNSSDSS--DSSDSDSSDSNSSSDSDSSDSDSSDSS 591
Query: 398 EKGRSSCGRNFWVSGLSSTTRATDLKNLFSKYGKVVGAKVVTNARSPGARCYGFVTMSTA 457
+ S + S S ++ ++D + S K +K +++ ++ + S+
Sbjct: 592 DSDSSDSSNSSDSSDSSDSSDSSDSSD--SSDSKSDSSKSESDSSDSDSK-----SDSSD 644
Query: 458 EEATKCINHLHKTELHGKMISVEKAKNEPVGKKTSDKRDSDGKKEKSSNSDRSTNLKRDD 517
++ ++ ++ S + + + +S DS + S +SD S + + D
Sbjct: 645 SNSSDSSDNSDSSDSSNSSNSSDSSDSSD-SSDSSSSSDSSNSSDSSDSSDSSNSSESSD 703
Query: 518 KCDRKD-DAKKGDDGSGEKSKDQDDQKPGPSERSRATKSGSRGTERTVVMDKSKGVPVIS 576
D D D+ D S S D D S S + S ++ + D S +
Sbjct: 704 SSDSSDSDSSDSSDSSNSNSSDSDSSNSSDSSDSSNSSDSSDSSDSSNSSDSSDSSDSSN 763
Query: 577 VKTSGSKERASKSQDRKSASREKRSVVSFDKVKEPRKSRDSESHSRVRERSE 628
S +S S D ++S S S D + S DS + S + S+
Sbjct: 764 SSDSSDSSDSSDSSDSSNSSDSNDSSNSSDS-SDSSNSSDSSNSSDSSDSSD 814
Score = 67.0 bits (162), Expect = 8e-11
Identities = 110/671 (16%), Positives = 221/671 (32%), Gaps = 43/671 (6%)
Query: 6 SGLGDSGAAGAAALSSASSETGTRRLSDLRVIDLRAELRKRNV-DSSGNKSVLMERLKKA 64
S DS + ++ SS S ++ SD D +++ N DSS N
Sbjct: 605 SDSSDSSDSSDSSDSSDSKSDSSKSESDSSDSDSKSDSSDSNSSDSSDNSDSSDSSNSSN 664
Query: 65 IEDEGGNPDEIEITSEGNKKTSKRSSKGRKPEEEGVEDNGLEENSGDGQEDVETSLENLQ 124
D + D + +S + S SS + + + D + ++S N
Sbjct: 665 SSDSSDSSDSSDSSSSSDSSNSSDSSDSSDSSNSSESSDSSDSSDSDSSDSSDSSNSNSS 724
Query: 125 DIDIMDISVLDEAE--------IDNGSVADCVEDDDADNLQESLSDSRELVEGEMKELPE 176
D D + S ++ D+ + +D + D+ N +S S + +
Sbjct: 725 DSDSSNSSDSSDSSNSSDSSDSSDSSNSSDSSDSSDSSNSSDSSDSSDSSDSSDSSNSSD 784
Query: 177 QLQEHAIEDKETINNL-------------DTSSSDFTILQEIEEPSLEPENEKILDILGE 223
D +N D+S SD + + S ++ D
Sbjct: 785 SNDSSNSSDSSDSSNSSDSSNSSDSSDSSDSSDSDSSNSSDSSNSSDSSDSSNSSDSSDS 844
Query: 224 TCKSEPVKEESSEL-------------EQPFAQDTSSVGPDRKLAEEEDLFDSAHPEEGD 270
+ S+ +SS + + D+S + + D DS++ + D
Sbjct: 845 SDSSDGSDSDSSNRSDSSNSSDSSDSSDSSNSSDSSDSSDSNESSNSSDSSDSSNSSDSD 904
Query: 271 LDLASESTAHAQSSKA----DSLLAVVKREPAEQPGDGERTDCEPVGLEPAVEQSSAASE 326
+S S+ + SS + +S + ++ + +D SS +S
Sbjct: 905 SSDSSNSSDSSDSSNSSDSSESSNSSDNSNSSDSSNSSDSSDSSDSSNSSDSSNSSDSSN 964
Query: 327 LAEASSEELAEAPTEAPSPEARDSKEDGRKFDFDACNEVPPAPKESSTSEGADQKMSSPE 386
+++S +++ + S ++ DS + D + + S +S+ ++ SS
Sbjct: 965 SSDSSDSNSSDSSDSSNSSDSSDSSDSSDSSDSSDSSNSSDSSDSSDSSDSSNSSDSSNS 1024
Query: 387 DDSDTKRLSKEEKGRSSCGRNFWVSGLSSTTRATDLKNLFSKYGKVVGAKVVTNARSPGA 446
DS S + S + S S ++ ++D + S ++ S +
Sbjct: 1025 SDSSNSSDSSDSSDSSDSSDSSDSSDSSDSSNSSDSSD--SSDSSDSSDSSDSSDSSDSS 1082
Query: 447 RCYGFVTMSTAEEATKCINHLHKTELHGKMISVEKAKNEPVGKKTSDKRDSDGKKEKSSN 506
S + +++ + ++ S + + + +SD DS + S++
Sbjct: 1083 ESSDSSDSSNSSDSSDSSDSSDSSDSSDSSDSSDSSDSSN-SSDSSDSSDSSDSSDSSNS 1141
Query: 507 SDRSTNLKRDDKCDRKDDAKKGDDG-SGEKSKDQDDQKPGPSERSRATKSGSRGTERTVV 565
SD S + + D D D + D S + S D S S + S ++ +
Sbjct: 1142 SDSSDSSESSDSSDSSDSSDSSDSSDSSDSSDSSDSSNSSDSSDSSDSSDSSDSSDSSDS 1201
Query: 566 MDKSKGVPVISVKTSGSKERASKSQDRKSASREKRSVVSFDKVKEPRKSRDSESHSRVRE 625
D S S +S S D ++ S S D S S+S
Sbjct: 1202 SDSSDSSDSSDSSDSSDSSDSSDSSDSSDSNESSDSSDSSDSSDSSNSSDSSDSSDSSDS 1261
Query: 626 RSEREQRMQAQ 636
S+ +Q
Sbjct: 1262 TSDSNDESDSQ 1272
Score = 66.6 bits (161), Expect = 1e-10
Identities = 95/598 (15%), Positives = 212/598 (35%), Gaps = 40/598 (6%)
Query: 6 SGLGDSGAAGAAALSSASSETGTRRLSDLRVIDLRAELRKRNVDSSGNKSVLMERLKKAI 65
S DS ++ ++ S +S+ + + SD N S + S +
Sbjct: 721 SNSSDSDSSNSSDSSDSSNSSDSSDSSD-----------SSNSSDSSDSSDSSNSSDSSD 769
Query: 66 EDEGGNPDEIEITSEGNKKTSKRSSKGRKPEEEGVEDNGLEENSGDGQEDVETSLENLQD 125
+ + + +S+ N ++ S + + ++S D S ++
Sbjct: 770 SSDSSDSSDSSNSSDSNDSSNSSDSSDSSNSSDSSNSSDSSDSSDSSDSDSSNSSDSSNS 829
Query: 126 IDIMDIS----VLDEAEIDNGSVADCVEDDDADNLQESLSDSRELVEGEMKELPEQLQE- 180
D D S D ++ +GS +D D+ N +S S + + + +
Sbjct: 830 SDSSDSSNSSDSSDSSDSSDGSDSDSSNRSDSSNSSDSSDSSDSSNSSDSSDSSDSNESS 889
Query: 181 HAIEDKETINNLDTSSSDFTILQEIEEPSLEPENEKILDILGETCKSEPVKEESSELEQP 240
++ + ++ N+ D+ SSD + + + S ++ + S + S+ +
Sbjct: 890 NSSDSSDSSNSSDSDSSDSSNSSDSSDSSNSSDSSE----------SSNSSDNSNSSDSS 939
Query: 241 FAQDTSSVGPDRKLAEEEDLFDSAHPEEGDLDLASESTAHAQSS-KADSLLAVVKREPAE 299
+ D+S ++ + DS++ + +S+S+ + SS +DS + + ++
Sbjct: 940 NSSDSSDSSDSSNSSDSSNSSDSSNSSDSSDSNSSDSSDSSNSSDSSDSSDSSDSSDSSD 999
Query: 300 QPGDGERTDCEPVGLEPAVEQSSAASELAEAS-SEELAEAPTEAPSPEARDSKEDGRKFD 358
+ +D SS +S+ + +S S + +++ + S ++ DS + D
Sbjct: 1000 SSNSSDSSDSSDSSDSSNSSDSSNSSDSSNSSDSSDSSDSSDSSDSSDSSDSSDSSNSSD 1059
Query: 359 FDACNEVPPAPKESSTSEGADQKMSSPEDDSDTKRLSKEEKGRSSCGRNFWVSGLSSTTR 418
++ + S +S+ +D SS DS S + S + S S ++
Sbjct: 1060 SSDSSDSSDSSDSSDSSDSSDSSESSDSSDSSNSSDSSDSSDSSDSSDS---SDSSDSSD 1116
Query: 419 ATDLKNLFSKYGKVVGAKVVTNARSPGARCYGFVTMSTAEEATKCINHLHKTELHGKMIS 478
++D N + ++ S + S + E++ + ++ S
Sbjct: 1117 SSDSSNSSDSSDSSDSSDSSDSSNSSDS--------SDSSESSDSSDSSDSSDSSDSSDS 1168
Query: 479 VEKAKNEPVGKKTSDKRDSDGKKEKSSNSDRSTNLKRDDKCDRKDDAKKGDDGSGEKSKD 538
+ + + +SD DS + S +SD S + D D D + D S D
Sbjct: 1169 SDSSDSSD-SSNSSDSSDSSDSSDSSDSSDSSDSSDSSDSSDSSDSSDSSDSSDSSDSSD 1227
Query: 539 QDDQKPGPSERSRATKSGSRGTERTVVMDKSKGVPVISVKTSGSKERASKSQDRKSAS 596
D + S S + + S S S S+ ++ + S S
Sbjct: 1228 SSDSNESSDSSDSSDSSDSSNSSDSSDSSDSSDSTSDSNDESDSQSKSGNGNNNGSDS 1285
Score = 64.7 bits (156), Expect = 4e-10
Identities = 100/603 (16%), Positives = 200/603 (33%), Gaps = 32/603 (5%)
Query: 6 SGLGDSGAAGAAALSSASSETGTRRLSDLRVIDLRAELRKRNVDSSGNKSVLMERLKKAI 65
S DS + ++ SS SS++ S D + S + S + +
Sbjct: 729 SNSSDSSDSSNSSDSSDSSDSSNSSDSS----DSSDSSNSSDSSDSSDSSDSSDSSNSSD 784
Query: 66 EDEGGNPDEIEITSEGNKKTSKRSSKGRKPEEEGVEDNGLEENSGDGQEDVETSLENLQD 125
++ N + +S + ++ S + N + ++ D S ++
Sbjct: 785 SNDSSNSSDSSDSSNSSDSSNSSDSSDSSDSSDSDSSNSSDSSNSSDSSDSSNSSDSSDS 844
Query: 126 IDIMDISVLDEAE-IDNGSVADCVEDDDADNLQESLSDSRELVEGEMKELPEQLQEHAIE 184
D D S D + D+ + +D + D+ N +S SDS + E +
Sbjct: 845 SDSSDGSDSDSSNRSDSSNSSDSSDSSDSSNSSDS-SDSSDSNESSNSSDSSDSSNSSDS 903
Query: 185 DKETINNLDTSSSDFTILQEIEEPSLEPENEKILDILGETCKSEPVKEESSELEQPFAQD 244
D +N + SSD + + E S +N D + S+ +SS
Sbjct: 904 DSSDSSN-SSDSSDSSNSSDSSESSNSSDNSNSSDSSNSSDSSD--SSDSSNSSDSSNSS 960
Query: 245 TSSVGPDRKLAEEEDLFDSAHPEEGDLDLASESTAHAQSSKADSLLAVVKREPAEQPGDG 304
SS D + D DS++ + D + S + S ++S + + ++
Sbjct: 961 DSSNSSDSSDSNSSDSSDSSNSSDSS-DSSDSSDSSDSSDSSNSSDSSDSSDSSDSSNSS 1019
Query: 305 ERTDCEPVGLEPAVEQSSAASELAEAS-SEELAEAPTEAPSPEARDSKEDGRKFDFDACN 363
+ ++ SS +S+ +++S S + +++ + S ++ DS + D +
Sbjct: 1020 DSSNSSDSSNSSDSSDSSDSSDSSDSSDSSDSSDSSNSSDSSDSSDSSDSSDSSDSSDSS 1079
Query: 364 EVPPAPKESSTSEGADQKMSSPEDDSDTKRLSKEEKGRSSCGRNFWVSGLSSTTRATDLK 423
+ + S +S +D SS DS S + S + S S ++ ++D
Sbjct: 1080 DSSESSDSSDSSNSSDSSDSSDSSDSSDSSDSSDSSDSSDSSNSSDSSDSSDSSDSSDSS 1139
Query: 424 NLFSKYGKVVGAKVVTNARSPGARCYGFVTMSTAEEATKCINHLHKTELHGKMISVEKAK 483
N ++ S + S + +++ + ++ +
Sbjct: 1140 N--------------SSDSSDSSESSDSSDSSDSSDSSDSSDSSDSSDS-------SDSS 1178
Query: 484 NEPVGKKTSDKRDSDGKKEKSSNSDRSTNLKRDDKCDRKDDAKKGDDGSGEKSKDQDDQK 543
N +SD DS + S +SD S + D D D + D S + D
Sbjct: 1179 NSSDSSDSSDSSDSSDSSDSSDSSDSSDSSDSSDSSDSSDSSDSSDSSDSSDSNESSDSS 1238
Query: 544 PGPSERSRATKSGSRGTERTVVMDKSKGVPVISVKTSGSKERASKSQDRKSASREKRSVV 603
+ S S + + S SG+ D S +
Sbjct: 1239 DSSDSSDSSNSSDSSDSSDSSDSTSDSNDESDSQSKSGNGNNNGSDSDSDSEGSDSNHST 1298
Query: 604 SFD 606
S D
Sbjct: 1299 SDD 1301
>gi|102467242 inner centromere protein antigens 135/155kDa isoform 2
[Homo sapiens]
Length = 914
Score = 80.9 bits (198), Expect = 5e-15
Identities = 100/435 (22%), Positives = 176/435 (40%), Gaps = 52/435 (11%)
Query: 295 REPAEQPGDGERTDCEP-----VGLEPAVEQSSAASELAEASSEELAEAPTEAPSPEARD 349
++ AE+P R C + +E + S E E +E +A A E P +
Sbjct: 341 KKTAEEPAASGRIICHSYLERLLNVEVPQKVGSEQKEPPE-EAEPVAAAEPEVPENNGNN 399
Query: 350 SKEDGRKFDFDACNEVP-PAPKESSTSEGADQKMSSPEDDSDTKRLSKEEKGRSSCGRNF 408
S D + N P P P SS + + + D +D R E +S+ +
Sbjct: 400 SWPHN---DTEIANSTPNPKPAASSPETPSAGQQEAKTDQADGPR----EPPQSARRKRS 452
Query: 409 WVSGLSSTTRATDLKNLFSKYGKVVGAKVVTNARSPGARCYGFVTMSTAEEATKCINHLH 468
+ +S L++ + + +++P + C A + + +
Sbjct: 453 YKQAVSELDEEQHLEDEELQPPR---------SKTPSSPC-------PASKVVRPLRTFL 496
Query: 469 KTELHGKMISVEKAKNEPVGKKTSDKRDSDGKKEKSSNSDRSTNLKRDDKCDRKDDAKKG 528
T +M+ + V K + K R NL+R ++ ++ K
Sbjct: 497 HTVQRNQMLMTPTSAPRSVMKSFIKRNTPLRMDPKEKERQRLENLRRKEEAEQLRRQKVE 556
Query: 529 DDGSGEKSKDQDDQKPGPSERSRATKSGSRGTERTVVMDKSKGVPVISVKTSGSKERASK 588
+D K + ++ K ER R E+ + +K K + + E+A +
Sbjct: 557 ED----KRRRLEEVKLKREERLRKVLQARERVEQ-MKEEKKKQIEQKFAQIDEKTEKAKE 611
Query: 589 SQDRKSASREKRSVVSFDKVKEPRKSRDSESHSRVRERSEREQRMQAQWER---EERERL 645
+ + +++K + ++V+ RK + R ++ E E+R Q ++ EE+ERL
Sbjct: 612 ERLAEEKAKKKAAAKKMEEVEARRKQEEEARRLRWLQQEEEERRHQELLQKKKEEEQERL 671
Query: 646 EIARE--RLAFQRQ------------RLERERMERERLERERMHVEHERRREQERIHRER 691
A E RLA QR+ R E+ER E+ER E+ER E ERRREQER+ ER
Sbjct: 672 RKAAEAKRLAEQREQERREQERREQERREQERREQERREQERQLAEQERRREQERLQAER 731
Query: 692 EELRRQQELRYEQER 706
E R++ LR ++E+
Sbjct: 732 ELQEREKALRLQKEQ 746
Score = 50.1 bits (118), Expect = 1e-05
Identities = 49/220 (22%), Positives = 96/220 (43%), Gaps = 33/220 (15%)
Query: 479 VEKAKNEPVGKKTSDKRDSDGKKEKSSNSDRSTNLKRDDKCDRKDDAKKGDDGSGEKSKD 538
VE+ K E + D K EK+ + ++K +K AKK ++ + ++
Sbjct: 584 VEQMKEEKKKQIEQKFAQIDEKTEKAKEERLA-----EEKAKKKAAAKKMEEVEARRKQE 638
Query: 539 QDDQKPGPSERSRATKSGSRGTERTVVMDKSKGVPVISVKTSGSKERASKSQDRKSASRE 598
++ + R R + ++ K K +ER K+ + K + +
Sbjct: 639 EE------ARRLRWLQQEEEERRHQELLQKKK---------EEEQERLRKAAEAKRLAEQ 683
Query: 599 KRSVVSFDKVKEPRKSRDSESHSRVRERSEREQRMQ--AQWEREERERLEIARE------ 650
+ ++ ++ R+ ++ R RE+ REQ Q Q R E+ERL+ RE
Sbjct: 684 REQ----ERREQERREQERREQER-REQERREQERQLAEQERRREQERLQAERELQEREK 738
Query: 651 RLAFQRQRLERERMERERLERERMHVEHERRREQERIHRE 690
L Q+++L+RE E+++ E ++ E + + EQE+ +E
Sbjct: 739 ALRLQKEQLQRELEEKKKKEEQQRLAERQLQEEQEKKAKE 778
Score = 43.5 bits (101), Expect = 9e-04
Identities = 66/339 (19%), Positives = 135/339 (39%), Gaps = 39/339 (11%)
Query: 485 EPVGKKTSDKRDSDGKKEKSSNSDRSTNLKRDDKCDRKDDAKKGDDGSGEKSKDQDDQKP 544
EPV + +++G N N + K A + S + + + DQ
Sbjct: 383 EPVAAAEPEVPENNGNNSWPHNDTEIANSTPNPK----PAASSPETPSAGQQEAKTDQAD 438
Query: 545 GPSE------RSRATKSGSRGTERTVVMDKSKGVPVISVKTSGSKERASK---------- 588
GP E R R+ K + ++ + P S KT S ASK
Sbjct: 439 GPREPPQSARRKRSYKQAVSELDEEQHLEDEELQPPRS-KTPSSPCPASKVVRPLRTFLH 497
Query: 589 ----SQDRKSASREKRSVV-SFDKVKEPR----KSRDSESHSRVRERSEREQRMQAQWER 639
+Q + + RSV+ SF K P K ++ + +R + E EQ + + E
Sbjct: 498 TVQRNQMLMTPTSAPRSVMKSFIKRNTPLRMDPKEKERQRLENLRRKEEAEQLRRQKVEE 557
Query: 640 EERERLEIARERLAFQRQRLERERMERERLERERMHVEHERRREQERIHREREELRRQQE 699
++R RLE + + + +RL + RER+E+ + + + ++ +I + E+ + ++
Sbjct: 558 DKRRRLEEVKLK---REERLRKVLQARERVEQMKEEKKKQIEQKFAQIDEKTEKAKEERL 614
Query: 700 LRYEQERRPAVRRPYDLDRRDDAYWPEAKRAAL-----DERYHSDFNRQDRFHDFDHRDR 754
+ +++ A ++ +++ R EA+R +ER H + ++ + + + +
Sbjct: 615 AEEKAKKKAAAKKMEEVEARRKQE-EEARRLRWLQQEEEERRHQELLQKKKEEEQERLRK 673
Query: 755 GRYPDHSVDRREGSRSMMGEREGQHYPERHGGPERHGRD 793
++RE R RE + + ER ++
Sbjct: 674 AAEAKRLAEQREQERREQERREQERREQERREQERREQE 712
Score = 35.0 bits (79), Expect = 0.32
Identities = 54/289 (18%), Positives = 112/289 (38%), Gaps = 26/289 (8%)
Query: 469 KTELHGKMISVEKAKNEPVGKKTSDKRDSDGKKEKSSNSDRSTNLKRDDKC--DRKDDAK 526
K L K SV + + + KKT+++ + G+ S +R N++ K ++K+ +
Sbjct: 321 KYSLVAKQESVVRRASRRLAKKTAEEPAASGRIICHSYLERLLNVEVPQKVGSEQKEPPE 380
Query: 527 KGD----------DGSGEKSKDQDDQK-------PGPSERSRATKSGSRGTERTVVMDKS 569
+ + + +G S +D + P P+ S T S + +T D
Sbjct: 381 EAEPVAAAEPEVPENNGNNSWPHNDTEIANSTPNPKPAASSPETPSAGQQEAKTDQADGP 440
Query: 570 KGVPVISVKTSGSKERASKSQDRKSASREKRSVVSFDKVKEPRKSRDSESHSRVRERSER 629
+ P + + K+ S+ + + E+ P + R + +
Sbjct: 441 REPPQSARRKRSYKQAVSELDEEQHLEDEELQPPRSKTPSSPCPASKVVRPLRTFLHTVQ 500
Query: 630 EQRMQAQWEREERERLEIARER---LAFQRQRLERERMERERLERERMHVEHERRREQER 686
+M R ++ +R L + ER+R+E R + E + ++ E +R
Sbjct: 501 RNQMLMTPTSAPRSVMKSFIKRNTPLRMDPKEKERQRLENLRRKEEAEQLRRQKVEEDKR 560
Query: 687 IHREREELRRQQELRYEQERRPAVRRPYDLDRRDDAYWPEAKRAALDER 735
E +L+R++ LR + R V + + ++ E K A +DE+
Sbjct: 561 RRLEEVKLKREERLRKVLQARERVEQMKEEKKKQ----IEQKFAQIDEK 605
>gi|116008442 zinc finger CCCH-type containing 13 [Homo sapiens]
Length = 1564
Score = 80.9 bits (198), Expect = 5e-15
Identities = 157/730 (21%), Positives = 270/730 (36%), Gaps = 83/730 (11%)
Query: 150 DDDADNLQESLSDSRELVEGEMKELPEQLQEHAIEDKETINNLDTSSSDFTILQEIEEPS 209
++ + +++ S R + ++K E+ E E+ E N D S + + E S
Sbjct: 106 EESSSPVRKESSRGRHREKEDIKITKERTPESEEENVEWETNRDDSDNGDINYDYVHELS 165
Query: 210 LEPENEKILDILGETCKSEPVKEESSELEQPFAQDT--SSVGPDRKLAEEEDLFDSAHPE 267
LE + +KI L + + K E +++ + + S + P L + S P+
Sbjct: 166 LEMKRQKIQRELMKLEQENMEKREEIIIKKEVSPEVVRSKLSPSPSLRK-----SSKSPK 220
Query: 268 EGDLDLASESTAHAQSSKADSLLAVVKREPAEQPGDGERTDCEPVGLEPAVEQSSAASEL 327
S + +SK D + V +Q + + + G ++
Sbjct: 221 R------KSSPKSSSASKKDRKTSAVSSPLLDQQRNSKTNQSKKKGPRTPSPPPPIPEDI 274
Query: 328 AEASSEELAEAPTEAPSPEARDSKEDGRKFDFDACNEVPPAPKESSTSEGADQKMSSPED 387
A + + + RD K+ GR DF+ E P+ +S + +SS
Sbjct: 275 ALGKKYKEKYKVKDRIEEKTRDGKDRGR--DFERQREKRDKPRSTSPAGQHHSPISSRHH 332
Query: 388 DSDTKRLSKEEKGRSSCGRNFWVSGLSSTTRATDLKNLFSKY-----GKVVGAKVVTNAR 442
S ++ S ++ S R S T L+ S Y + R
Sbjct: 333 SSSSQSGSSIQRHSPSPRRKRTPSPSYQRTLTPPLRRSASPYPSHSLSSPQRKQSPPRHR 392
Query: 443 SPGARCYGFVTMSTAEEATKCINHLHKTELHGK----MISVEKAKNEPVGKKTSDKRDS- 497
SP T++ + H + + GK S E+ + E + D RD
Sbjct: 393 SPMREKGRHDHERTSQSHDR--RHERREDTRGKRDREKDSREEREYEQDQSSSRDHRDDR 450
Query: 498 ---DGKKEKSSNSDRSTNLKRDDKCDRKDDAKKGDDGSGEKSKDQDDQKPGPSERSRATK 554
DG+ + + R RD + D +D + D S+D + + RS
Sbjct: 451 EPRDGRDRRDARDTRDRRELRDSR-DMRDSREMRD-----YSRDTKESRDPRDSRSTRDA 504
Query: 555 SGSRGTERTVVMDKSKGVPVISVKTSGS--KERASKSQDRKSASREKRSVVSFDKV---- 608
R E K P S + +E +S+++ R + E RS + D++
Sbjct: 505 HDYRDREGRDTHRKEDTYPEESRSYGRNHLREESSRTEIRNESRNESRSEIRNDRMGRSR 564
Query: 609 --------KEPRKSRDS--ESHSRVRERSEREQRMQAQWERE---ERERLEIARERLAFQ 655
K R SR S +SHS + + + ER+ ER+ + AR+ +F+
Sbjct: 565 GRVPELPEKGSRGSRGSQIDSHSSNSNYHDSWETRSSYPERDRYPERDNRDQARDS-SFE 623
Query: 656 RQRLERERME-RERLERERMHVEH---------ERRREQERIHR---EREELRRQQELRY 702
R+ ER+R + RER +R + H + RRE+ R+ R R+E R+++
Sbjct: 624 RRHGERDRRDNRERDQRPSSPIRHQGRNDELERDERREERRVDRVDDRRDERARERDRER 683
Query: 703 EQERRPAVRRPYDLDR-RDDAYWPEAKRAALDERYHSDFNRQDRFHDFDHRDRGRYPDHS 761
E++R R + DR R+ E +RA ER ++R D DH DR R +
Sbjct: 684 ERDRERERERERERDREREKERELERERAREREREREKERDRERDRDRDH-DRERERERE 742
Query: 762 VDRREGSRSMMGEREGQHYPERHGGPERHGRDSRDGWGGYGSDKRMSEGRGLPPPPRRDW 821
DR + ERE + ER ER ++ + R +RDW
Sbjct: 743 RDREKEREREREERERERERERERERERE------------RERERARERDKERERQRDW 790
Query: 822 GDHGRREDDR 831
D + DDR
Sbjct: 791 EDKDKGRDDR 800
Score = 80.1 bits (196), Expect = 9e-15
Identities = 164/743 (22%), Positives = 285/743 (38%), Gaps = 107/743 (14%)
Query: 40 RAELRKRNVDSSGNKSVLMERLKKAIEDEGGNPDEIEITSEGNKKTSKRSSKGRKPEEEG 99
R R+R D K +ER ++A E E E + + ++ + + R+ + E
Sbjct: 689 RERERERERDREREKERELER-ERAREREREREKERDRERDRDRDHDRERERERERDREK 747
Query: 100 VEDNGLEENSGDGQEDVETSLENLQDIDIM-----------DISVLDEAEIDNGSVADCV 148
+ EE + + + E E ++ + D D+ D + +
Sbjct: 748 EREREREERERERERERERERERERERERARERDKERERQRDWEDKDKGRDDRREKREEI 807
Query: 149 EDD--DADNLQESLSDSRELVEGEM--KELPEQLQEHAIEDKETINNLDTSSSDFTILQE 204
+D D E S R EG ++ P++ +EH+ D + N+ D + +L +
Sbjct: 808 REDRNPRDGHDERKSKKRYRNEGSPSPRQSPKRRREHS-PDSDAYNSGDDKNEKHRLLSQ 866
Query: 205 IEEP----SLEPENEKILDILGETCKSE---PVKEESSEL--EQPFAQDTSSVGPDRKLA 255
+ P SL P + + + K E P ++ESS EQ + SSV R
Sbjct: 867 VVRPQESRSLSPSH--LTEDRQGRWKEEDRKPERKESSRRYEEQELKEKVSSVDKQR--- 921
Query: 256 EEEDLFDSAHPEEGDL-------DLASESTAHAQSSKADSLLAVVKREPAEQP------- 301
E+ ++ +S+ D+ D + AH ++ K A ++++P ++
Sbjct: 922 EQTEILESSRMRAQDIIGHHQSEDRETSDRAHDENKKK----AKIQKKPIKKKKEDDVGI 977
Query: 302 --GDGERTDCEPVGLEPAVEQSSAASEL--------AEASSEELAEAPTEAPSPEARDSK 351
G+ E T + P Q + E ++ S EE A+ + P R
Sbjct: 978 ERGNIETTSEDGQVFSPKKGQKKKSIEKKRKKSKGDSDISDEEAAQQSKKKRGP--RTPP 1035
Query: 352 EDGRKFDFDACNEVPPAPKESSTSEGADQKMSSPEDDSDTKRLSKEEKGRSSCGRNFWVS 411
++ + CN ++S E S ED D +++ E ++ S
Sbjct: 1036 ITTKEELVEMCNGKNGILEDSQKKEDTAFSDWSDEDVPDRTEVTEAEHTATATTPGSTPS 1095
Query: 412 GLSS---------TTRATDLKNLFSKYGKVVGAKVVTNARSPGARCYGFVTMSTAEEATK 462
LSS T AT + + T+A +T+ST+ T
Sbjct: 1096 PLSSLLPPPPPVATATATTVPATLAATTAAAATSFSTSA----------ITISTSATPTN 1145
Query: 463 CINHLHKTE-LHGKM--ISVEKAKNEPVG-KKTSDKRDSDGKKEKSSNSDRSTNLKRDDK 518
N+ E H K VEK + V + ++ D K+ S S+RS +
Sbjct: 1146 TTNNTFANEDSHRKCHRTRVEKVETPHVTIEDAQHRKPMDQKRSSSLGSNRSNRSHTSGR 1205
Query: 519 C--DRKDDA-KKGDDGSGEKSKDQDDQKPGPSERSRATKSGSRGTERTVVMDKSKGVPVI 575
D A + GDD SG K G +R + G ++ + +G P
Sbjct: 1206 LRSPSNDSAHRSGDDQSGRKRVLHS----GSRDREKTKSLEITGERKSRIDQLKRGEP-- 1259
Query: 576 SVKTSGSKERASKSQDRKSASREKRSVVS----FDKVKEPRKSRDSESHSRVRERSEREQ 631
S TS ++ + R+S+ R V S FD ++ + RD H R RER R+
Sbjct: 1260 SRSTSSDRQDSRSHSSRRSSPESDRQVHSRSGSFDS-RDRLQERDRYEHDRERERERRDT 1318
Query: 632 RMQAQWEREERERLEIARERLAFQRQRLERERMERERLERERMH-----VEHERRREQER 686
R Q +W+R+ + R+R + + ERER +R L+RER VE +R R+++R
Sbjct: 1319 R-QREWDRDADKDWPRNRDRDRLRERERERERDKRRDLDRERERLISDSVERDRDRDRDR 1377
Query: 687 IHR--EREELRR-QQELRYEQER 706
+ E ++R + +L E ER
Sbjct: 1378 TFESSQIESVKRCEAKLEGEHER 1400
Score = 71.2 bits (173), Expect = 4e-12
Identities = 93/358 (25%), Positives = 150/358 (41%), Gaps = 49/358 (13%)
Query: 482 AKNEPVGKKTSDKRDSDGKKEKSSNSDRSTNLKRDDKCDRKDDAKKGDDGSGEKSKDQD- 540
++ + +S+ D + +SS +R +RD++ +D + + G ++ +++
Sbjct: 578 SRGSQIDSHSSNSNYHDSWETRSSYPERDRYPERDNRDQARDSSFERRHGERDRRDNRER 637
Query: 541 DQKPGPSERSRATKSGSRGTERTVVMDKSKGVPVISVKTSGSKERASKSQDRKSASREKR 600
DQ+P R + ER + + V + + ERA + + RE+
Sbjct: 638 DQRPSSPIRHQGRNDELERDERR----EERRVDRVDDRRD---ERARERDRERERDRERE 690
Query: 601 SVVSFDKVKEPRKSRDSESHSRVRERS-EREQRMQAQWEREERERLEIARERLAFQRQRL 659
++ +E K R+ E R RER ERE+ + +R+ E RER + +
Sbjct: 691 RERERERDREREKERELE-RERAREREREREKERDRERDRDRDHDRERERERERDREKER 749
Query: 660 ERERMERERLERERMHVEHERRREQERIHREREELRRQQELRYEQERRPAVRRPYDLDRR 719
ERER ERER ERER ER RE+ER RERE R + + E+ER +R
Sbjct: 750 EREREERER-ERER-----ERERERER-ERERERARERDK---ERER-----------QR 788
Query: 720 DDAYWPEAKRAALDERYHSDFNRQDR----FHDFDHRDRGRYPDHSVDRREGSRS--MMG 773
D W + + D R + R+DR HD + + + RY R EGS S
Sbjct: 789 D---WEDKDKGRDDRREKREEIREDRNPRDGHD-ERKSKKRY------RNEGSPSPRQSP 838
Query: 774 EREGQHYPERHGGPERHGRDSRDGWGGYGSDKRMSEGRGLPPPPRRDWGDHGRREDDR 831
+R +H P+ G D + R E R L P + +E+DR
Sbjct: 839 KRRREHSPD--SDAYNSGDDKNEKHRLLSQVVRPQESRSLSPSHLTEDRQGRWKEEDR 894
Score = 62.8 bits (151), Expect = 1e-09
Identities = 89/386 (23%), Positives = 146/386 (37%), Gaps = 40/386 (10%)
Query: 478 SVEKAKNEPVGKKTSDKRDSDGKKEKSSNSDRSTNLKRDDKCDRKDDAKKG--------- 528
S+ K+ P +K+S K S KK++ +++ S L + KKG
Sbjct: 211 SLRKSSKSPK-RKSSPKSSSASKKDRKTSAVSSPLLDQQRNSKTNQSKKKGPRTPSPPPP 269
Query: 529 ---DDGSGEKSKDQDDQKPGPSERSRATKSGSRGTERT-VVMDKSKGV--------PVIS 576
D G+K K++ K E++R K R ER DK + P+ S
Sbjct: 270 IPEDIALGKKYKEKYKVKDRIEEKTRDGKDRGRDFERQREKRDKPRSTSPAGQHHSPISS 329
Query: 577 VKTSGSKERASKSQDRKSASREKRSVV-SFDKVKEPRKSRDSE---SHS----RVRERSE 628
S S + S Q + R KR+ S+ + P R + SHS + ++
Sbjct: 330 RHHSSSSQSGSSIQRHSPSPRRKRTPSPSYQRTLTPPLRRSASPYPSHSLSSPQRKQSPP 389
Query: 629 REQRMQAQWEREERERLEIARERLAFQRQRLERERMERERLERERMHVEHERRREQERIH 688
R + + R + ER + +R + +R E R +R+R + R E+E+ + R H
Sbjct: 390 RHRSPMREKGRHDHERTSQSHDR---RHERREDTRGKRDREKDSREEREYEQDQSSSRDH 446
Query: 689 REREELRRQQELRYEQERRPAVRRPYDLDRRDDAYWPEAKRAALDERYHSDFNRQDRFHD 748
R+ E R ++ R ++ R D RD + R + R D HD
Sbjct: 447 RDDREPRDGRDRRDARDTRDRRELRDSRDMRDSREMRDYSRDTKESRDPRDSRSTRDAHD 506
Query: 749 FDHRDRGRYPDHSVDRREGSRSMMGEREGQHYPERHGGPERHGRDSRDGWGGYGSDKRMS 808
+ RDR H R+E + G+++ +SR+ + RM
Sbjct: 507 Y--RDREGRDTH---RKEDTYPEESRSYGRNHLREESSRTEIRNESRNESRSEIRNDRMG 561
Query: 809 EGRGLPP--PPRRDWGDHGRREDDRS 832
RG P P + G G + D S
Sbjct: 562 RSRGRVPELPEKGSRGSRGSQIDSHS 587
Score = 50.1 bits (118), Expect = 1e-05
Identities = 57/289 (19%), Positives = 115/289 (39%), Gaps = 38/289 (13%)
Query: 480 EKAKNEPVGKKTSDKRDSDGKKEKSSNSDRS--TNLKRDDKCDRKDDAKKGDDGSGEKSK 537
E+ ++ ++ +RD + +KE+ +R+ +R+ + DR+ D + D E+ +
Sbjct: 682 ERERDRERERERERERDREREKERELERERAREREREREKERDRERDRDRDHDRERERER 741
Query: 538 DQDDQKPGPSERSRATKSGSRGTERTVVMDKSKGVPVISVKTSGSKERASKSQDR---KS 594
++D +K ER + R ER ++ + + + +ER +D+ +
Sbjct: 742 ERDREKEREREREERERERERERERERERERER---ERARERDKERERQRDWEDKDKGRD 798
Query: 595 ASREKRSVVSFDKVKEPRKSRDS----------------ESHSRVRERSEREQRMQAQWE 638
REKR + D + PR D +S R RE S + +
Sbjct: 799 DRREKREEIRED--RNPRDGHDERKSKKRYRNEGSPSPRQSPKRRREHSPDSDAYNSGDD 856
Query: 639 REERERL-----------EIARERLAFQRQ-RLERERMERERLERERMHVEHERRREQER 686
+ E+ RL ++ L RQ R + E + ER E R + E E + +
Sbjct: 857 KNEKHRLLSQVVRPQESRSLSPSHLTEDRQGRWKEEDRKPERKESSRRYEEQELKEKVSS 916
Query: 687 IHREREELRRQQELRYEQERRPAVRRPYDLDRRDDAYWPEAKRAALDER 735
+ ++RE+ + R + + D + D A+ K+A + ++
Sbjct: 917 VDKQREQTEILESSRMRAQDIIGHHQSEDRETSDRAHDENKKKAKIQKK 965
Score = 48.1 bits (113), Expect = 4e-05
Identities = 48/236 (20%), Positives = 98/236 (41%), Gaps = 28/236 (11%)
Query: 494 KRDSDGKKEKSSNSDRSTNLKRDDKCDRK---DDAKKGDDGSGEKSKD-QDDQKPGPSER 549
+R+ + ++E+ +R +RD + +R+ +D KG D EK ++ ++D+ P
Sbjct: 759 ERERERERERERERERERARERDKERERQRDWEDKDKGRDDRREKREEIREDRNPRDGHD 818
Query: 550 SRATKSGSRGTERTVVMDKSKGVPVISVKTSGSKERASKSQDRKSASREKRSVVSFDKVK 609
R +K R ++G P +E + S S + +V
Sbjct: 819 ERKSKKRYR----------NEGSPSPRQSPKRRREHSPDSDAYNSGDDKNEKHRLLSQVV 868
Query: 610 EPRKSRDSESHSRVRERSEREQRMQAQWEREER--ERLEIARERLAFQRQRLERERMERE 667
P++SR +R Q +W+ E+R ER E +R ++ Q L+ + +
Sbjct: 869 RPQESRSLSPSHLTEDR-------QGRWKEEDRKPERKESSRR---YEEQELKEKVSSVD 918
Query: 668 RLERERMHVEHERRREQERIHREREELRRQQELRYEQERRPA--VRRPYDLDRRDD 721
+ + +E R R Q+ I + E R + +++ ++ A ++P + DD
Sbjct: 919 KQREQTEILESSRMRAQDIIGHHQSEDRETSDRAHDENKKKAKIQKKPIKKKKEDD 974
Score = 37.0 bits (84), Expect = 0.084
Identities = 68/316 (21%), Positives = 116/316 (36%), Gaps = 49/316 (15%)
Query: 545 GPSERSRATKSGSRGTERTVVMD-----KSKGVPVISVKTSGSKERASKSQDRKSASREK 599
GPS R + S R + D K+K V + + E +S S RK +SR +
Sbjct: 62 GPSPRGKGYSSNYRRSPERPTGDLRERMKNKRQDVDTEPQKRNTEESS-SPVRKESSRGR 120
Query: 600 RSVVSFDKVKEPRKSRDSESHSRVRERSEREQRMQAQWEREERERLEIARERLAFQRQRL 659
K+ + R E + + ++ LE+ R+++ + +L
Sbjct: 121 HREKEDIKITKERTPESEEENVEWETNRDDSDNGDINYDYVHELSLEMKRQKIQRELMKL 180
Query: 660 ERERMERERLERERMHVEHERRREQERI-------------HREREELRRQQELRYEQER 706
E+E ME+ RE + ++ E E R +R+ + + +
Sbjct: 181 EQENMEK----REEIIIKKEVSPEVVRSKLSPSPSLRKSSKSPKRKSSPKSSSASKKDRK 236
Query: 707 RPAVRRPYDLDRRDDAYWPEAKR---------------AALDERYHSDFNRQDRFHD--F 749
AV P LD++ ++ ++K+ AL ++Y + +DR +
Sbjct: 237 TSAVSSPL-LDQQRNSKTNQSKKKGPRTPSPPPPIPEDIALGKKYKEKYKVKDRIEEKTR 295
Query: 750 DHRDRGRYPDHSVDRREGSRSMMGEREGQHY---PERHGGPERHGRDSRDGWGGYGSDKR 806
D +DRGR + ++R+ RS GQH+ RH S KR
Sbjct: 296 DGKDRGRDFERQREKRDKPRST--SPAGQHHSPISSRHHSSSSQSGSSIQRHSPSPRRKR 353
Query: 807 M---SEGRGLPPPPRR 819
S R L PP RR
Sbjct: 354 TPSPSYQRTLTPPLRR 369
>gi|148746195 trichohyalin [Homo sapiens]
Length = 1943
Score = 79.7 bits (195), Expect = 1e-14
Identities = 60/268 (22%), Positives = 126/268 (47%), Gaps = 13/268 (4%)
Query: 480 EKAKNEPVGKKTSDKRDSDGKKEKSSNSDRSTNLKRDDKCDRKDDAKKGDDGSGEKSKDQ 539
++ E G++ KR ++E + ++S +R ++ DR+ + D+ + ++
Sbjct: 126 DRQLEEEPGQRRRQKRQEQ-ERELAEGEEQSEKQERLEQRDRQ----RRDEELWRQRQEW 180
Query: 540 DDQKPGPSERSRATKSGSRGTERTVVMDKSKGVPVISVKTSGSKERASKSQDRKSASREK 599
+++ +E + TE ++ + ++ ++ G +E+ + ++R+ ++
Sbjct: 181 QEREERRAEEEQLQSCKGHETEEFPDEEQLRRRELLELRRKGREEKQQQRRERQDRVFQE 240
Query: 600 RSVVSFDKVKEPRKSRDSESHSRVRERSEREQRMQAQWEREERERLEIARERLAFQRQRL 659
+ K + + + + +R Q + Q + ER+ L R+ Q+QRL
Sbjct: 241 EEEKEWRKRETVLRKEEEKLQEEEPQRQRELQEEEEQLRKLERQELRRERQEEEQQQQRL 300
Query: 660 ERERMERERLERERMHVEHERRREQERIHREREELRRQQELRYEQE--RRPAVRRPYDLD 717
RE+ R + E ER + ERR +QER RE++E RR+Q+LR EQE R +RR + +
Sbjct: 301 RREQQLRRKQEEERREQQEERREQQER--REQQEERREQQLRREQEERREQQLRREQEEE 358
Query: 718 RRDDAYWPEAKRAALDERYHSDFNRQDR 745
RR+ + +R +ER R+ +
Sbjct: 359 RREQ----QLRREQEEERREQQLRREQQ 382
Score = 73.6 bits (179), Expect = 8e-13
Identities = 83/375 (22%), Positives = 161/375 (42%), Gaps = 26/375 (6%)
Query: 480 EKAKNEPVGKKTSDKRDSDGKKEKSSNSDRSTNLKRDDKCDRKDDAKKGDDGSGEKSKDQ 539
E+ E K+ +R+ ++E+ + L+ + + R+ + ++ E +++
Sbjct: 971 EQLLGEEPEKRRRQEREKKYREEEELQQEEEQLLREEREKRRRQEWERQYRKKDELQQEE 1030
Query: 540 DDQKPGPSERSRATKSGSRGTERTVVMDKSKGVPVISVKTSGSKERASKSQDRKSASREK 599
+ E+ R + + E + + + ++ + + + + Q RK ++
Sbjct: 1031 EQLLREEREKRRLQERERQYREEEELQQEEE--QLLGEERETRRRQELERQYRKEEELQQ 1088
Query: 600 RSVVSFDKVKEPRKSRDSESHSRVRERSEREQRMQAQWEREERERLEIAR-----ERLAF 654
+ E R+ ++ E R E ++E+ + ERE+R R E+ R E +
Sbjct: 1089 EEEQLLREEPEKRRRQERERQCREEEELQQEEEQLLREEREKRRRQELERQYREEEEVQQ 1148
Query: 655 QRQRLERERME-RERLERERMHVEHER-RREQERIHREREELRRQQ-ELRYEQE----RR 707
+ ++L RE E R R E ER + E E ++E+E++ RE +E RRQ+ E +Y +E R+
Sbjct: 1149 EEEQLLREEPEKRRRQELERQYREEEELQQEEEQLLREEQEKRRQERERQYREEEELQRQ 1208
Query: 708 PAVRRPYDLDRRDDAYW---PEAKRAALDERYHSDFNRQDRF---HDFDHRDRGRYPD-- 759
+R D D+R D W PE + A D + + ++F D RDR D
Sbjct: 1209 KRKQRYRDEDQRSDLKWQWEPEKENAVRDNKVYCKGRENEQFRQLEDSQLRDRQSQQDLQ 1268
Query: 760 HSVDRREGSRSMMGEREGQHYPERHGGPERHGRDSRDGWGGYGSDKRMSEGRGLPPPPRR 819
H + ++ R ER +RH PE + + D++ E + L R
Sbjct: 1269 HLLGEQQ-ERDREQERRRWQQRDRH-FPEEEQLEREEQKEAKRRDRKSQEEKQLLREERE 1326
Query: 820 DWGDHGRREDDRSWQ 834
+ R+E DR ++
Sbjct: 1327 E--KRRRQETDRKFR 1339
Score = 73.2 bits (178), Expect = 1e-12
Identities = 63/306 (20%), Positives = 130/306 (42%), Gaps = 16/306 (5%)
Query: 480 EKAKNEPVGKKTSDKRDSDGKKEKSSNSDRSTNLKRDDKCDRKDDAKKGDDGSGEKSKDQ 539
E K E V +K +K + + + + L++ ++ + + + ++ + ++Q
Sbjct: 245 EWRKRETVLRKEEEKLQEEEPQRQRELQEEEEQLRKLERQELRRERQEEEQQQQRLRREQ 304
Query: 540 DDQKPGPSERSRATKSGSRGTERTVVMDKSKGVPVISVKTSGSKERASKSQDRKSASREK 599
++ ER + ER ++ + + +E + Q R+ E+
Sbjct: 305 QLRRKQEEERREQQEERREQQERREQQEERR-----EQQLRREQEERREQQLRREQEEER 359
Query: 600 RSVVSFDKVKEPRKSRDSESHSRVRERSEREQRMQAQWEREERERLEIARERLAFQRQRL 659
R + +E R+ + ++R + + Q + E++ R ++ RE+ + Q+L
Sbjct: 360 REQQLRREQEEERREQQLRREQQLRREQQLRREQQLRREQQLRREQQLRREQQLRREQQL 419
Query: 660 ERERMERERLERERMHVEHERRREQERIHREREE----LRRQQEL-RYEQERR-PAVRRP 713
RE+ R E ER +HE+ R ++R+ RE+EE L+R++E R+EQERR ++R
Sbjct: 420 RREQQLRREQEEERHEQKHEQERREQRLKREQEERRDWLKREEETERHEQERRKQQLKRD 479
Query: 714 YDLDRRDDAYW---PEAKRAALDERYHSDFNRQDRFHDFDHRDRGRYPDHSVDRREGSRS 770
+ +RR+ W E +R ER R+ R + R +
Sbjct: 480 QEEERRE--RWLKLEEEERREQQERREQQLRREQEERREQRLKRQEEEERLQQRLRSEQQ 537
Query: 771 MMGERE 776
+ E+E
Sbjct: 538 LRREQE 543
Score = 69.7 bits (169), Expect = 1e-11
Identities = 54/199 (27%), Positives = 87/199 (43%), Gaps = 15/199 (7%)
Query: 585 RASKSQDRKSASREKRSVVSFDKVKEPRKSRDSESHSRVRERSEREQRMQAQWEREERER 644
R + ++ + R +R K +E R+ + E + R ++E+R + Q RE+ ER
Sbjct: 287 RRERQEEEQQQQRLRREQQLRRKQEEERREQQEERREQQERREQQEERREQQLRREQEER 346
Query: 645 LEIARERLAFQRQRLERERMERERLERERMHVEHERRREQ---ERIHREREELRRQQELR 701
E Q+L RE+ E R ++ R E ERR +Q E+ R ++LRR+Q+LR
Sbjct: 347 RE----------QQLRREQEEERREQQLRREQEEERREQQLRREQQLRREQQLRREQQLR 396
Query: 702 YEQE--RRPAVRRPYDLDRRDDAYWPEAKRAALDERYHSDFNRQDRFHDFDHRDRGRYPD 759
EQ+ R +RR L R + R +E H + Q+R R++ D
Sbjct: 397 REQQLRREQQLRREQQLRREQQLRREQQLRREQEEERHEQKHEQERREQRLKREQEERRD 456
Query: 760 HSVDRREGSRSMMGEREGQ 778
E R R+ Q
Sbjct: 457 WLKREEETERHEQERRKQQ 475
Score = 66.2 bits (160), Expect = 1e-10
Identities = 89/395 (22%), Positives = 158/395 (40%), Gaps = 50/395 (12%)
Query: 489 KKTSDKRDSDGKKEKSSNSDRSTNLKRDDKCDRKDDAKKGDDGSGEKSKDQDDQKPGPSE 548
++ ++R+ ++E+ R LKR ++ +R + + + +++ +Q E
Sbjct: 497 REQQERREQQLRREQEER--REQRLKRQEEEERLQQRLRSEQQLRREQEERREQLLKREE 554
Query: 549 RSRATKSGSRGTERTVVMDKSKGVPVISVKTSGSKERASKSQDRKSASREKRSVVSFDKV 608
R + R +R + + ++ + ++R + Q+ + R KR V +
Sbjct: 555 EKRLEQE--RREQRLKREQEERRDQLLKREEERRQQRLKREQEERLEQRLKREEVERLEQ 612
Query: 609 KEPRKSR------DSESHSRVRERSEREQRMQAQWEREERERLEIARERLAFQR---QRL 659
+E R+ R + E ++ + E+E+R Q Q RE++ER E +R + QRL
Sbjct: 613 EERREQRLKREEPEEERRQQLLKSEEQEERRQQQLRREQQERREQRLKREEEEERLEQRL 672
Query: 660 ERERMERERLERERMHVEHERRRE--QERIHREREEL---------------RRQQELRY 702
+RE E ER E+E E E+ RE + RI + + +L R+Q+ R
Sbjct: 673 KREH-EEERREQELAEEEQEQARERIKSRIPKWQWQLESEADARQSKVYSRPRKQEGQRR 731
Query: 703 EQERRPAVRRPYDLDRRDDAYWPEAKRA---ALDERYHSDFNRQDRFHDFDHRDRGRYPD 759
QE+ RR R + W E +RA +E DF Q + + R R R
Sbjct: 732 RQEQEEKRRR-----RESELQWQEEERAHRQQQEEEQRRDFTWQWQAEEKSERGRQRLSA 786
Query: 760 HSVDRREGSRSMMGEREGQHYPERHGGPERHGRDSRDGWGGYGSDKRMSEGRGLPPPPRR 819
R + R + E Q E+ PE ++ R +R R
Sbjct: 787 RPPLREQRERQLRAEERQQR--EQRFLPEEEEKEQR---------RRQRREREKELQFLE 835
Query: 820 DWGDHGRREDDRSWQGTADGGMMDRDHKRWQGGER 854
+ RRE + Q DG D++ +R Q R
Sbjct: 836 EEEQLQRRERAQQLQEEEDGLQEDQERRRSQEQRR 870
Score = 64.7 bits (156), Expect = 4e-10
Identities = 65/344 (18%), Positives = 140/344 (40%), Gaps = 30/344 (8%)
Query: 457 AEEATKCINHLHKTELHGKMISVEKAKNEPVGKKTSDKRDSDGKKEKSSNSDRSTNLKRD 516
AEE + K+ + +E + K S R +G++ + ++
Sbjct: 686 AEEEQEQARERIKSRIPKWQWQLESEADARQSKVYSRPRKQEGQRRRQEQEEKRRR---- 741
Query: 517 DKCDRKDDAKKGDDGSGEKSKDQDDQKPGPSERSRATKSGSRGTERTVVMDKSKGVPVIS 576
R+ + + ++ + + +++Q+ + + +A + RG +R +
Sbjct: 742 ----RESELQWQEEERAHRQQQEEEQRRDFTWQWQAEEKSERGRQRLSARPPLREQRERQ 797
Query: 577 VKTSGSKERASK-------SQDRKSASREKRSVVSF----------DKVKEPRKSRDSES 619
++ ++R + + R+ RE+ + F ++ ++ ++ D
Sbjct: 798 LRAEERQQREQRFLPEEEEKEQRRRQRREREKELQFLEEEEQLQRRERAQQLQEEEDGLQ 857
Query: 620 HSRVRERSE---REQRMQAQWEREERERLEIARERLAFQRQ-RLERERMERERLERERMH 675
+ R RS+ R+Q+ + Q E E + R + A Q Q R E++ ++ E E +R
Sbjct: 858 EDQERRRSQEQRRDQKWRWQLEEERKRRRHTLYAKPALQEQLRKEQQLLQEEEEELQREE 917
Query: 676 VEHERRREQERIHREREELRRQQELRYEQERRPAVRRPYDLDRRDDAYWPEAKRAALDER 735
E RR+EQER +RE E+L++++E +ER R+ + R D + + L E
Sbjct: 918 REKRRRQEQERQYREEEQLQQEEEQLLREEREKRRRQERERQYRKDKKLQQKEEQLLGEE 977
Query: 736 YHSDFNRQDRFHDFDHRDRGRYPDHSVDRREGSRSMMGEREGQH 779
RQ+R + + + + + R E + E E Q+
Sbjct: 978 PEKR-RRQEREKKYREEEELQQEEEQLLREEREKRRRQEWERQY 1020
Score = 63.5 bits (153), Expect = 8e-10
Identities = 85/422 (20%), Positives = 161/422 (38%), Gaps = 54/422 (12%)
Query: 480 EKAKNEPVGKKTSDKRDSDGKKEKSSNSD----RSTNLKRDDKCDRKDDAKKGDDGSGEK 535
E+ + + + ++ +R+ ++E+ + R L+R+ + R+ ++ E+
Sbjct: 370 EERREQQLRREQQLRREQQLRREQQLRREQQLRREQQLRREQQLRREQQLRREQQLRREQ 429
Query: 536 SKDQDDQKPGPSERSRATKSGSRGTERTVVMDKSKGVPVISVKTSGSKERASKSQDRKSA 595
+++ +QK R + K ER + + + +T ++ K Q ++
Sbjct: 430 EEERHEQKHEQERREQRLKREQE--ERRDWLKREE-------ETERHEQERRKQQLKRDQ 480
Query: 596 SREKRSVVSFDKVKEPRKSRDSESHSRVRERSEREQRMQAQWEREERERLE--------I 647
E+R + K++E + E + R + E+R Q +EE ERL+ +
Sbjct: 481 EEERRE--RWLKLEEEERREQQERREQQLRREQEERREQRLKRQEEEERLQQRLRSEQQL 538
Query: 648 ARERLAFQRQRLERE------------RMERERLERERMHVEHERRREQERIHREREELR 695
RE+ + Q L+RE R++RE+ ER ++ E R Q+R+ RE+EE
Sbjct: 539 RREQEERREQLLKREEEKRLEQERREQRLKREQEERRDQLLKREEERRQQRLKREQEERL 598
Query: 696 RQQELRYEQERRPAVRRPYDLDRRDDAYWPEAKRAALDERYHSDFNRQDRFHDFDHRDRG 755
Q+ R E ER R +R++ ++ E +Q R + R++
Sbjct: 599 EQRLKREEVERLEQEERREQRLKREEPEEERRQQLLKSEEQEERRQQQLRREQQERREQR 658
Query: 756 RYPDHSVDRREG--SRSMMGEREGQHYPERHGGPERHGRDSR-DGWGGYGSDKRMSEGRG 812
+ +R E R ER Q E R SR W + +
Sbjct: 659 LKREEEEERLEQRLKREHEEERREQELAEEEQEQARERIKSRIPKWQWQLESEADARQSK 718
Query: 813 LPPPPRRDWGD---------HGRREDDRSWQGTADGGMMDRDHK-------RWQGGERSM 856
+ PR+ G RRE + WQ ++ + +WQ E+S
Sbjct: 719 VYSRPRKQEGQRRRQEQEEKRRRRESELQWQEEERAHRQQQEEEQRRDFTWQWQAEEKSE 778
Query: 857 SG 858
G
Sbjct: 779 RG 780
Score = 62.4 bits (150), Expect = 2e-09
Identities = 75/321 (23%), Positives = 137/321 (42%), Gaps = 37/321 (11%)
Query: 480 EKAKNEPVGKKTSDKRDSDGKKEKSSNSDRSTNLKRDDKCDRK--DDAKKGDDGSGEKSK 537
E+ + E +K + +RD ++EK + +R + DRK ++ + + + +
Sbjct: 1295 EEEQLEREEQKEAKRRDRKSQEEKQLLREEREEKRRRQETDRKFREEEQLLQEREEQPLR 1354
Query: 538 DQDDQKPGPSERSRATKSGSRGTE---RTVVMDKSKGVPVISVKTSGSKERASKSQDRKS 594
Q+ + E R + G + E R ++ + + + QDR
Sbjct: 1355 RQERDRKFREEELRHQEQGRKFLEEEQRLRRQERERKFLKEEQQLRCQEREQQLRQDRDR 1414
Query: 595 ASREKRSVVSFDKVKEPRKSRDSESHSRVRERS----EREQRMQAQWEREERERLEIARE 650
RE+ +S + + RK R+ E R +ER E EQ+++ + R+ RE ++ +E
Sbjct: 1415 KFREEEQQLS--RQERDRKFREEEQQVRRQERERKFLEEEQQLRQERHRKFREEEQLLQE 1472
Query: 651 RLAFQRQRLERER--MERE----RLERERMHVEHERRREQERIHREREELRRQQELRYEQ 704
R Q R ER+R +E E R ER+R E E R ++ ER+ L +Q+L +Q
Sbjct: 1473 REEQQLHRQERDRKFLEEEQQLRRQERDRKFREQELRSQEP----ERKFLEEEQQLHRQQ 1528
Query: 705 ERRPAVRRPYDLDRRD---------DAYWPEAKRAALDERYHSDFNRQDRFHDFDHRDRG 755
+R ++ L R++ D + E ++ ER +RQ+R F
Sbjct: 1529 RQRKFLQEEQQLRRQERGQQRRQDRDRKFREEEQLR-QEREEQQLSRQERDRKF------ 1581
Query: 756 RYPDHSVDRREGSRSMMGERE 776
R + V R+E R M + +
Sbjct: 1582 RLEEQKVRRQEQERKFMEDEQ 1602
Score = 62.4 bits (150), Expect = 2e-09
Identities = 56/202 (27%), Positives = 94/202 (46%), Gaps = 13/202 (6%)
Query: 583 KERASKSQDRKSASREKRSVVSFDKVKEPRKSRDSESHSRVRERSE-REQRMQAQWEREE 641
+ER K ++ + R + F ++E ++ R E + RE + R++ Q Q R+E
Sbjct: 1687 QERDRKFREEEQQLRRQERERKF--LQEEQQLRRQELERKFREEEQLRQETEQEQLRRQE 1744
Query: 642 RERLEIARERLAFQRQRLERERMERERLERERMHVEHERRREQERIHREREELRRQQELR 701
R R + E+L +R+ + R ER+R RE + ER +Q R + R +++LR
Sbjct: 1745 RYRKILEEEQLRPEREEQQLRRQERDRKFREEEQLRQEREEQQLRSQESDRKFREEEQLR 1804
Query: 702 YEQERRPAVRRPYDLDRRDDAYWPEAKRAALDERYHSDFNRQDRFHDFDHRDRGRYPDHS 761
QER RP +RD Y E ++ L+E+ RQ+R D +R ++
Sbjct: 1805 --QEREEQQLRP---QQRDGKYRWEEEQLQLEEQ--EQRLRQER--DRQYRAEEQFATQE 1855
Query: 762 VDRREGSRSMMGEREGQHYPER 783
RRE + + E E + ER
Sbjct: 1856 KSRRE-EQELWQEEEQKRRQER 1876
Score = 62.0 bits (149), Expect = 2e-09
Identities = 72/290 (24%), Positives = 129/290 (44%), Gaps = 32/290 (11%)
Query: 588 KSQDRKSASREKRSVVSFDKVKEPRKSRDSESHSR--VRERSEREQRMQAQWEREERERL 645
+ Q+R+ + ++R +++E RK R +++ ++E+ +EQ++ Q E EE +R
Sbjct: 858 EDQERRRSQEQRRDQKWRWQLEEERKRRRHTLYAKPALQEQLRKEQQL-LQEEEEELQRE 916
Query: 646 EIARERLAFQRQRLERERMERERLERER---MHVEHERRREQERIHREREELRRQQ---- 698
E + R RQ ER+ E E+L++E + E E+RR QER + R++ + QQ
Sbjct: 917 EREKRR----RQEQERQYREEEQLQQEEEQLLREEREKRRRQERERQYRKDKKLQQKEEQ 972
Query: 699 ------ELRYEQERRPAVRRPYDLDRRDDAYWPEAKRAALDERYHSDFNRQDRFHDFDHR 752
E R QER R +L + ++ + R ++R ++ RQ R D +
Sbjct: 973 LLGEEPEKRRRQEREKKYREEEELQQEEE----QLLREEREKRRRQEWERQYRKKDELQQ 1028
Query: 753 DRGRYPDHSVDRR---EGSRSMMGEREGQHYPERHGGPERHGRDSRDGWGGYGSDKRMSE 809
+ + ++R E R E E Q E+ G ER R ++ Y ++ + +
Sbjct: 1029 EEEQLLREEREKRRLQERERQYREEEELQQEEEQLLGEERETRRRQELERQYRKEEELQQ 1088
Query: 810 G-----RGLPPPPRRDWGDHGRREDDRSWQGTADGGMMDRDHKRWQGGER 854
R P RR + RE++ Q +R+ +R Q ER
Sbjct: 1089 EEEQLLREEPEKRRRQERERQCREEEELQQEEEQLLREEREKRRRQELER 1138
Score = 60.1 bits (144), Expect = 9e-09
Identities = 48/205 (23%), Positives = 93/205 (45%), Gaps = 6/205 (2%)
Query: 583 KERASKSQDRKSASREKRSVVSFDKVKEPRKSRDSESHSRVRERSEREQRMQAQWEREER 642
+E+ + + K +E+ DK + ++ + R R ERE++ + + E ++
Sbjct: 940 EEQLLREEREKRRRQERERQYRKDKKLQQKEEQLLGEEPEKRRRQEREKKYREEEELQQE 999
Query: 643 ERLEIARERLAFQRQRLERERMERERLERER---MHVEHERRR--EQERIHREREELRRQ 697
E + ER +RQ ER+ +++ L++E + E E+RR E+ER +RE EEL+++
Sbjct: 1000 EEQLLREEREKRRRQEWERQYRKKDELQQEEEQLLREEREKRRLQERERQYREEEELQQE 1059
Query: 698 QELRYEQERRPAVRRPYDLDRRDDAYWPEAKRAALDERYHSDFNRQDRFHDFDHRDRGRY 757
+E +ER R+ + R + + + L E RQ+R + +
Sbjct: 1060 EEQLLGEERETRRRQELERQYRKEEELQQEEEQLLREEPEKR-RRQERERQCREEEELQQ 1118
Query: 758 PDHSVDRREGSRSMMGEREGQHYPE 782
+ + R E + E E Q+ E
Sbjct: 1119 EEEQLLREEREKRRRQELERQYREE 1143
Score = 59.7 bits (143), Expect = 1e-08
Identities = 83/396 (20%), Positives = 156/396 (39%), Gaps = 58/396 (14%)
Query: 467 LHKTELHGKMISVEKAKNEPVGKKTSDKRDSDGKKEKSSNSDRSTNLKRDDKCD-RKDDA 525
L + E K E EP K +++ ++ + L+R ++ R+ D
Sbjct: 1494 LRRQERDRKFREQELRSQEPERKFLEEEQQLHRQQRQRKFLQEEQQLRRQERGQQRRQDR 1553
Query: 526 KKGDDGSGEKSKDQDDQKPGPSERSRA-----TKSGSRGTERTVVMDKSKGVPVISVKTS 580
+ + +++++Q+ ER R K + ER + D+ + ++
Sbjct: 1554 DRKFREEEQLRQEREEQQLSRQERDRKFRLEEQKVRRQEQERKFMEDEQQ------LRRQ 1607
Query: 581 GSKERASKSQDRKSASREK----RSVVSFDKVKEPRKSRDSESHSRVRERSEREQRMQAQ 636
+++ + +DRK E+ R + + RK + E R R EREQ+++
Sbjct: 1608 EGQQQLRQERDRKFREDEQLLQEREEQQLHRQERDRKFLEEEPQLR---RQEREQQLRHD 1664
Query: 637 WEREERERLEIARERLAFQRQRLERERMERE------RLERERMHVEHE---RRREQERI 687
+R+ RE ++ +E Q +R ER+R RE R ERER ++ E RR+E ER
Sbjct: 1665 RDRKFREEEQLLQEGEEQQLRRQERDRKFREEEQQLRRQERERKFLQEEQQLRRQELERK 1724
Query: 688 HREREELRRQQE------------------LRYEQERRPAVRRPYDLDRRDDAYW----- 724
RE E+LR++ E LR E+E + R+ D R++
Sbjct: 1725 FREEEQLRQETEQEQLRRQERYRKILEEEQLRPEREEQQLRRQERDRKFREEEQLRQERE 1784
Query: 725 ------PEAKRAALDERYHSDFNRQDRFHDFDHRDRGRYPDHSVDRREGSRSMMGEREGQ 778
E+ R +E + + + R+ + + E + + ER+ Q
Sbjct: 1785 EQQLRSQESDRKFREEEQLRQEREEQQLRPQQRDGKYRWEEEQLQLEEQEQRLRQERDRQ 1844
Query: 779 H-YPERHGGPERHGRDSRDGWGGYGSDKRMSEGRGL 813
+ E+ E+ R+ ++ W +R R L
Sbjct: 1845 YRAEEQFATQEKSRREEQELWQEEEQKRRQERERKL 1880
Score = 58.9 bits (141), Expect = 2e-08
Identities = 61/219 (27%), Positives = 96/219 (43%), Gaps = 20/219 (9%)
Query: 583 KERASKSQDRKSASREKRSVVSFDKVKEPRKSRDSESHSRVRERSEREQRMQAQWEREER 642
+E Q S R+++S + ++ RD E R ++ +R + Q EREE+
Sbjct: 1245 RENEQFRQLEDSQLRDRQSQQDLQHLLGEQQERDREQERRRWQQRDRHFPEEEQLEREEQ 1304
Query: 643 ERLEIARERLAFQRQRLERERME-RERLERERMHVEHER----RREQERIHREREELRRQ 697
+ + + ++Q L ER E R R E +R E E+ R EQ +ER+ R+
Sbjct: 1305 KEAKRRDRKSQEEKQLLREEREEKRRRQETDRKFREEEQLLQEREEQPLRRQERDRKFRE 1364
Query: 698 QELRYEQERRPAVRRPYDLDR--RDDAYWPEAKRAALDERYHSDFNRQDRFHDF------ 749
+ELR++++ R + L R R+ + E ++ ER RQDR F
Sbjct: 1365 EELRHQEQGRKFLEEEQRLRRQERERKFLKEEQQLRCQEREQQ--LRQDRDRKFREEEQQ 1422
Query: 750 ---DHRDRG-RYPDHSVDRREGSRSMMGEREGQHYPERH 784
RDR R + V R+E R + E E Q ERH
Sbjct: 1423 LSRQERDRKFREEEQQVRRQERERKFL-EEEQQLRQERH 1460
Score = 58.5 bits (140), Expect = 3e-08
Identities = 58/222 (26%), Positives = 99/222 (44%), Gaps = 29/222 (13%)
Query: 581 GSKERASKSQDRKSASREKRSVVSFDKVKEPRKSRDSESHSRVRERSEREQRMQAQWERE 640
G ++ + Q+R+ + R +E + R+ + ++ R+R +E++ + ERE
Sbjct: 1272 GEQQERDREQERRRWQQRDRHFP-----EEEQLEREEQKEAKRRDRKSQEEKQLLREERE 1326
Query: 641 ERERLEIARERLAFQRQRL-ERERMERERLERERMHVEHERRREQE------------RI 687
E+ R + + + Q L ERE R ER+R E E R +++ R
Sbjct: 1327 EKRRRQETDRKFREEEQLLQEREEQPLRRQERDRKFREEELRHQEQGRKFLEEEQRLRRQ 1386
Query: 688 HREREELRRQQELRYEQERRPAVRRPYDLDRRDDAYWPEAKRAALDERYHSD---FNRQD 744
RER+ L+ +Q+LR QER +R+ D DR+ + R D ++ + RQ+
Sbjct: 1387 ERERKFLKEEQQLRC-QEREQQLRQ--DRDRKFREEEQQLSRQERDRKFREEEQQVRRQE 1443
Query: 745 RFHDF-DHRDRGRYPDHSVDRREGSRSMMGEREGQ--HYPER 783
R F + + R H R E ++ ERE Q H ER
Sbjct: 1444 RERKFLEEEQQLRQERHRKFREE--EQLLQEREEQQLHRQER 1483
Score = 56.6 bits (135), Expect = 1e-07
Identities = 41/131 (31%), Positives = 68/131 (51%), Gaps = 8/131 (6%)
Query: 584 ERASKSQDRKSASREKRSVVSFDKVKEPRKSRDSESHSRVRE----RSEREQRMQAQWER 639
ER + R+ R+ R + +E ++ R ES + RE R ERE++ +R
Sbjct: 1758 EREEQQLRRQERDRKFREEEQLRQEREEQQLRSQESDRKFREEEQLRQEREEQQLRPQQR 1817
Query: 640 EERERLEIARERLAFQRQRLERERMERERLERERMHVEHERRREQERIHREREELRRQQ- 698
+ + R E + +L Q QRL +ER + R E E+ + + RRE++ + +E E+ RRQ+
Sbjct: 1818 DGKYRWEEEQLQLEEQEQRLRQERDRQYRAE-EQFATQEKSRREEQELWQEEEQKRRQER 1876
Query: 699 --ELRYEQERR 707
+LR E RR
Sbjct: 1877 ERKLREEHIRR 1887
Score = 56.2 bits (134), Expect = 1e-07
Identities = 76/370 (20%), Positives = 152/370 (41%), Gaps = 34/370 (9%)
Query: 513 LKRDDKCDRKDDAKK---GDDGSGEKSKDQDDQKPGPSERSRATKSGSRGTERTVVMDKS 569
L+ +++ R++ A++ +DG E + + Q+ ++ R R R + K
Sbjct: 834 LEEEEQLQRRERAQQLQEEEDGLQEDQERRRSQEQRRDQKWRWQLEEERKRRRHTLYAK- 892
Query: 570 KGVPVISVKTSGSKERASKSQDR-KSASREKRSVVSFDKVKEPRKSRDSESHSRVRE--- 625
P + + ++ + ++ + REKR ++ + E +RE
Sbjct: 893 ---PALQEQLRKEQQLLQEEEEELQREEREKRRRQEQERQYREEEQLQQEEEQLLREERE 949
Query: 626 ---RSEREQRMQAQWEREERERLEIARERLAFQRQRLERERMERERLERE-----RMHVE 677
R ERE++ + + +++E + E +RQ E++ E E L++E R E
Sbjct: 950 KRRRQERERQYRKDKKLQQKEEQLLGEEPEKRRRQEREKKYREEEELQQEEEQLLREERE 1009
Query: 678 HERRREQERIHREREELRRQQE--LRYE------QERRPAVRRPYDLDRRDDAYWPEAKR 729
RR+E ER +R+++EL++++E LR E QER R +L + ++ E +
Sbjct: 1010 KRRRQEWERQYRKKDELQQEEEQLLREEREKRRLQERERQYREEEELQQEEEQLLGEERE 1069
Query: 730 AALDERYHSDFNRQDRFHDFDHRDRGRYPDHSVDRREGSRSMMGEREGQHYPERHGGPER 789
+ + +++ + + P+ R+E R E E Q E+ ER
Sbjct: 1070 TRRRQELERQYRKEEELQQEEEQLLREEPEKR-RRQERERQCREEEELQQEEEQLLREER 1128
Query: 790 HGRDSRDGWGGYGSDKRMSEG-----RGLPPPPRRDWGDHGRREDDRSWQGTADGGMMDR 844
R ++ Y ++ + + R P RR + RE++ Q + + +
Sbjct: 1129 EKRRRQELERQYREEEEVQQEEEQLLREEPEKRRRQELERQYREEE-ELQQEEEQLLREE 1187
Query: 845 DHKRWQGGER 854
KR Q ER
Sbjct: 1188 QEKRRQERER 1197
Score = 55.1 bits (131), Expect = 3e-07
Identities = 84/392 (21%), Positives = 167/392 (42%), Gaps = 30/392 (7%)
Query: 480 EKAKNEPVGKKTSDKRDSDGKKEKSSNSDRSTNLKRDDKCDRKDD--AKKGDDGSGEKSK 537
E+ + + + ++ ++R+ K+E+ LKR+ + +R++ A++ + + E+ K
Sbjct: 640 EERRQQQLRREQQERREQRLKREEEEER-LEQRLKREHEEERREQELAEEEQEQARERIK 698
Query: 538 DQDDQKPGPSER---SRATKSGSRGTERTVVMDKSKGVPVISVKTSGSKERASKSQDRKS 594
+ + E +R +K SR ++ + + + S + + + R+
Sbjct: 699 SRIPKWQWQLESEADARQSKVYSRPRKQEGQRRRQEQEEKRRRRESELQWQEEERAHRQQ 758
Query: 595 ASREKRSVVSFDKVKEPRKSRDSESHS-RVRERSEREQRMQAQWEREERERLEIARERLA 653
E+R ++ E + R + S R R +RE++++A+ ER++RE+ + E
Sbjct: 759 QEEEQRRDFTWQWQAEEKSERGRQRLSARPPLREQRERQLRAE-ERQQREQRFLPEEEEK 817
Query: 654 FQRQRLERER-MERERLERERMHVEHERRREQERIHREREELRRQQELRYEQERRPAVRR 712
QR+R RER E + LE E + +RR +++ E + L+ QE R QE+R +
Sbjct: 818 EQRRRQRREREKELQFLEEEE---QLQRRERAQQLQEEEDGLQEDQERRRSQEQRRDQKW 874
Query: 713 PYDLD-----RRDDAYWPEAKRAALDERYHSDFNRQDRFHDFDHRDRGRYPDHSVDRREG 767
+ L+ RR Y + AL E+ ++ + + + R R+E
Sbjct: 875 RWQLEEERKRRRHTLY----AKPALQEQ----LRKEQQLLQEEEEELQREEREKRRRQEQ 926
Query: 768 SRSMMGEREGQHYPERHGGPERHGRDSRDGWGGYGSDKRMSEGRGL-----PPPPRRDWG 822
R E + Q E+ ER R ++ Y DK++ + P RR
Sbjct: 927 ERQYREEEQLQQEEEQLLREEREKRRRQERERQYRKDKKLQQKEEQLLGEEPEKRRRQER 986
Query: 823 DHGRREDDRSWQGTADGGMMDRDHKRWQGGER 854
+ RE++ Q +R+ +R Q ER
Sbjct: 987 EKKYREEEELQQEEEQLLREEREKRRRQEWER 1018
Score = 50.4 bits (119), Expect = 7e-06
Identities = 55/283 (19%), Positives = 121/283 (42%), Gaps = 24/283 (8%)
Query: 518 KCDRKDDAKKGDDGSGEKSKDQDDQKPGPSERSRATKSGSRGTERTVVMDKSKGVPVISV 577
+CD K+ + ++ +++D ++ P +R + G R ++ ++
Sbjct: 102 RCDGKESLLQ------DRRQEEDQRRFEPRDRQLEEEPGQRRRQKRQEQER--------- 146
Query: 578 KTSGSKERASKSQDRKSASREKRSVVSFDKVKE--PRKSRDSESHSRVRERSEREQRMQA 635
+ + +E++ K + + R++R + + +E R+ R +E + +
Sbjct: 147 ELAEGEEQSEKQERLEQRDRQRRDEELWRQRQEWQEREERRAEEEQLQSCKGHETEEFPD 206
Query: 636 QWEREERERLEIARERLAFQRQRLERERMER---ERLERERMHVEHERRREQERIHRERE 692
+ + RE LE+ R+ ++Q+ RER +R E E+E E R+E+E++ + E
Sbjct: 207 EEQLRRRELLELRRKGRE-EKQQQRRERQDRVFQEEEEKEWRKRETVLRKEEEKL--QEE 263
Query: 693 ELRRQQELRYEQERRPAVRRPYDLDRRDDAYWPEAKRAALDERYHSDFNRQDRFHDFDHR 752
E +RQ+EL+ E+E+ + R +L R + +R +++ + R + R
Sbjct: 264 EPQRQRELQEEEEQLRKLER-QELRRERQEEEQQQQRLRREQQLRRKQEEERREQQEERR 322
Query: 753 DRGRYPDHSVDRREGSRSMMGEREGQHYPERHGGPERHGRDSR 795
++ + +RRE E + R ER + R
Sbjct: 323 EQQERREQQEERREQQLRREQEERREQQLRREQEEERREQQLR 365
Score = 46.6 bits (109), Expect = 1e-04
Identities = 37/147 (25%), Positives = 66/147 (44%), Gaps = 18/147 (12%)
Query: 610 EPRKSRDSESHSRVRERSEREQRMQAQWEREERERLEIARERLAFQRQRLERERMERERL 669
E +++R S +++R + E Q ++E +R+ E QR+R +R+ ERE
Sbjct: 97 EEKRARCDGKESLLQDRRQEED--QRRFEPRDRQL-----EEEPGQRRRQKRQEQERELA 149
Query: 670 ERERMHVEHERRREQERIHREREELRRQQELRYEQERRPAVRRPYDLDRRDDAYWP---- 725
E E + ER +++R R+ E R++QE + +ERR + + +P
Sbjct: 150 EGEEQSEKQERLEQRDRQRRDEELWRQRQEWQEREERRAEEEQLQSCKGHETEEFPDEEQ 209
Query: 726 -------EAKRAALDERYHSDFNRQDR 745
E +R +E+ RQDR
Sbjct: 210 LRRRELLELRRKGREEKQQQRRERQDR 236
Score = 38.9 bits (89), Expect = 0.022
Identities = 40/150 (26%), Positives = 72/150 (48%), Gaps = 18/150 (12%)
Query: 579 TSGSKERASKSQDRKSASREKRSVVSFDKVKEPRKSRDSESHSRVRERSEREQRMQAQWE 638
T +E+ ++ ++S +++R + + + + E R R++ + ++R A+ E
Sbjct: 93 TGLDEEKRARCDGKESLLQDRRQEEDQRRFEPRDRQLEEEPGQRRRQKRQEQERELAEGE 152
Query: 639 R--EERERLEIARERLAFQRQRLERERMERERLERERMHVEHERRREQERIH----RERE 692
E++ERLE R+R QR+ E R +E ERE ERR E+E++ E E
Sbjct: 153 EQSEKQERLE-QRDR---QRRDEELWRQRQEWQERE------ERRAEEEQLQSCKGHETE 202
Query: 693 ELRRQQELRYEQ--ERRPAVRRPYDLDRRD 720
E +++LR + E R R RR+
Sbjct: 203 EFPDEEQLRRRELLELRRKGREEKQQQRRE 232
Score = 38.1 bits (87), Expect = 0.038
Identities = 33/119 (27%), Positives = 59/119 (49%), Gaps = 10/119 (8%)
Query: 587 SKSQDRKSASREKRSVVSFDKVKEPR----KSRDSESHSRVRERSER-EQRMQAQWEREE 641
S+ DRK E+ ++ P+ K R E ++ E+ +R Q Q+ EE
Sbjct: 1790 SQESDRKFREEEQLRQEREEQQLRPQQRDGKYRWEEEQLQLEEQEQRLRQERDRQYRAEE 1849
Query: 642 RERLEIARERLAFQRQRLERERMERERLERER-MHVEHERRRE-QERIHREREELRRQQ 698
+ +E+ + Q L +E ++ R ERER + EH RR++ +E+ HR+ E++ Q+
Sbjct: 1850 Q---FATQEKSRREEQELWQEEEQKRRQERERKLREEHIRRQQKEEQRHRQVGEIKSQE 1905
Score = 35.0 bits (79), Expect = 0.32
Identities = 38/148 (25%), Positives = 65/148 (43%), Gaps = 6/148 (4%)
Query: 638 EREERERLEIARERLAFQRQRLERERME-RER-LERERMHVEHERRREQERIHREREELR 695
+ E+R R + L +RQ ++ R E R+R LE E RR++++ RE E
Sbjct: 96 DEEKRARCDGKESLLQDRRQEEDQRRFEPRDRQLEEEP---GQRRRQKRQEQERELAEGE 152
Query: 696 RQQELRYEQERRPAVRRPYDLDRRDDAYWPEAKRAALDERYHS-DFNRQDRFHDFDHRDR 754
Q E + E+R RR +L R+ + +R A +E+ S + + F D + R
Sbjct: 153 EQSEKQERLEQRDRQRRDEELWRQRQEWQEREERRAEEEQLQSCKGHETEEFPDEEQLRR 212
Query: 755 GRYPDHSVDRREGSRSMMGEREGQHYPE 782
+ RE + ER+ + + E
Sbjct: 213 RELLELRRKGREEKQQQRRERQDRVFQE 240
>gi|239754909 PREDICTED: hypothetical protein [Homo sapiens]
Length = 245
Score = 79.3 bits (194), Expect = 1e-14
Identities = 57/219 (26%), Positives = 107/219 (48%), Gaps = 15/219 (6%)
Query: 480 EKAKNEPVGKKTSDKRDSDGKKEKSSNSDRSTNLKRDDKCDRKDDAKKGDDGSGEKSKDQ 539
E+ + K+ +R+S+ KKE+ R +++ K +R KKG E+ K++
Sbjct: 40 EREREIETRKEGKKERESERKKERREREKRKREREKERKRERGKKEKKG-----ERKKEE 94
Query: 540 DDQKPGPSERSRATKSGSRGTERTVVMDKSKGVPVISVKTSGSKERASKSQDRKSASREK 599
++K R + K G +R K +G +TS + + ++RK R++
Sbjct: 95 RERKK--RRREKENKEGEEKEKRKKKEKKERG------RTSKEGKERERKEERKREERKE 146
Query: 600 RSVVSFDKVKE-PRKSRDSESHSRVRERSE-REQRMQAQWEREERERLEIARERLAFQRQ 657
R ++ KE RK R +V E+ E R+++ + + ++ ER R E +ER +R+
Sbjct: 147 RERKKEEREKERERKERKKRERKQVGEKEEERKEKERKERKKRERNRKERKKERERKERR 206
Query: 658 RLERERMERERLERERMHVEHERRREQERIHREREELRR 696
++ER ++E ++ER RE+ER RER+E ++
Sbjct: 207 ERKKERKKKEERKKERQKDRQTNWREKERGKRERKERKK 245
Score = 74.7 bits (182), Expect = 4e-13
Identities = 56/207 (27%), Positives = 101/207 (48%), Gaps = 10/207 (4%)
Query: 534 EKSKDQDDQKPGPSERSRATKSGSRGTERTVVMDKSKGVPVISVKTSGSKERASKSQDRK 593
E+ ++ + +K G ER K R E+ ++ K K ER + ++RK
Sbjct: 40 EREREIETRKEGKKERESERKKERREREKRK-REREKERKRERGKKEKKGERKKEERERK 98
Query: 594 SASREKRSVVSFDKVKEPRKSRDSESHSRV----RERSEREQRMQAQWEREERERLEIAR 649
REK + +K E RK ++ + R +ER +E+R + ER+ERER + R
Sbjct: 99 KRRREKENKEGEEK--EKRKKKEKKERGRTSKEGKERERKEERKRE--ERKERERKKEER 154
Query: 650 ERLAFQRQRLERERMERERLERERMHVEHERRREQERIHREREELRRQQELR-YEQERRP 708
E+ +++R +RER + E ER E + R+++ER +ER++ R ++E R ++ER+
Sbjct: 155 EKERERKERKKRERKQVGEKEEERKEKERKERKKRERNRKERKKERERKERRERKKERKK 214
Query: 709 AVRRPYDLDRRDDAYWPEAKRAALDER 735
R + + W E +R + +
Sbjct: 215 KEERKKERQKDRQTNWREKERGKRERK 241
Score = 70.9 bits (172), Expect = 5e-12
Identities = 54/193 (27%), Positives = 95/193 (49%), Gaps = 11/193 (5%)
Query: 575 ISVKTSGSKERAS-KSQDRKSASREKRSVVSFDKVKEPRKSRDSESHSRVRERSEREQRM 633
I + G KER S + ++R+ + KR K + +K + E RER +R +
Sbjct: 45 IETRKEGKKERESERKKERREREKRKREREKERKRERGKKEKKGERKKEERERKKRRREK 104
Query: 634 Q-AQWEREERERLEIARERLAFQRQRLERERMER----ERLERERMHVEHERRREQ-ERI 687
+ + E +E+ + + +ER ++ ERER E ER ERER E E+ RE+ ER
Sbjct: 105 ENKEGEEKEKRKKKEKKERGRTSKEGKERERKEERKREERKERERKKEEREKERERKERK 164
Query: 688 HREREELRRQQELRYEQERRPAVRRPYDLDRRDDAYWPEAKRAALDERYHSDFNRQDRFH 747
RER+++ ++E R E+ER+ +R + R + +R ER + +++R
Sbjct: 165 KRERKQVGEKEEERKEKERKERKKRERNRKERKKERERKERRERKKERKKKEERKKERQK 224
Query: 748 D----FDHRDRGR 756
D + ++RG+
Sbjct: 225 DRQTNWREKERGK 237
Score = 67.0 bits (162), Expect = 8e-11
Identities = 56/211 (26%), Positives = 104/211 (49%), Gaps = 7/211 (3%)
Query: 583 KERASKSQDRKSASREKRSVVSFDKVKEPRKSRDSESHSRVRERSEREQRMQAQWEREER 642
+ER + + RK +E+ S ++ + ++ R+ E R RER ++E++ + ++EER
Sbjct: 39 REREREIETRKEGKKERESERKKERREREKRKREREKE-RKRERGKKEKK--GERKKEER 95
Query: 643 ERLEIARERLAFQRQRLERERMERERLERERMHVE-HERRREQERIHREREELRRQQELR 701
ER + RE+ + + E+ R ++E+ ER R E ER R++ER ER+E R++E R
Sbjct: 96 ERKKRRREKENKEGEEKEK-RKKKEKKERGRTSKEGKERERKEERKREERKERERKKEER 154
Query: 702 YEQERRPAVRRPYDLDRRDDAYWPEAKRAALDERYHSDFNRQDRFHDFDHRDRGRYPDHS 761
E+ER R+ + + + E K ER + NR++R + + ++R
Sbjct: 155 -EKERERKERKKRERKQVGEKE-EERKEKERKERKKRERNRKERKKERERKERRERKKER 212
Query: 762 VDRREGSRSMMGEREGQHYPERHGGPERHGR 792
+ E + +R+ + G ER R
Sbjct: 213 KKKEERKKERQKDRQTNWREKERGKRERKER 243
Score = 54.3 bits (129), Expect = 5e-07
Identities = 57/199 (28%), Positives = 95/199 (47%), Gaps = 14/199 (7%)
Query: 602 VVSFDKVKEPRKSRDSESHSRVRERSEREQRMQAQWEREERERLEIARERLAFQRQRLER 661
+VS + +P +S R RER E E R + + ERE ER + RER +R+R +
Sbjct: 19 MVSCSHISKPCTQPGWQSEIRERER-EIETRKEGKKERES-ERKKERREREKRKREREKE 76
Query: 662 ERMERERLER--ERMHVEHE---RRREQERIHREREELRRQQELRYEQERRPAVRRPYDL 716
+ ER + E+ ER E E RRRE+E E +E R+++E ++ER + +
Sbjct: 77 RKRERGKKEKKGERKKEERERKKRRREKENKEGEEKEKRKKKE---KKERGRTSKEGKER 133
Query: 717 DRRDDAYWPEAKRAALDERYHSDFNRQDRFHDFDHRDRGRYPDHSVDRREGSRSMMGERE 776
+R+++ E K ER + ++ + R+R + + +R+E R +RE
Sbjct: 134 ERKEERKREERKER---ERKKEEREKERERKERKKRERKQVGEKEEERKEKERKERKKRE 190
Query: 777 GQHYPERHGGPERHGRDSR 795
++ ER ER R R
Sbjct: 191 -RNRKERKKERERKERRER 208
>gi|56549694 enabled homolog isoform a [Homo sapiens]
Length = 591
Score = 77.4 bits (189), Expect = 6e-14
Identities = 50/134 (37%), Positives = 75/134 (55%), Gaps = 11/134 (8%)
Query: 617 SESHSRVRERSEREQRMQAQWEREERERLEIARERLAFQRQRLERERMERERLERERMHV 676
S+ ++ R +EQ+ Q + ERE ER + RERL +R+RLERER+ERERLE+E++
Sbjct: 136 SQEELEIQRRQLQEQQRQKELERERLERERMERERL--ERERLERERLERERLEQEQLER 193
Query: 677 EHERRREQERIHRE-----REELRRQQELRYEQERRPAVRRPYDLDRRDDAYWPEAKRAA 731
E + R QER+ R+ +E L RQ+ L E++ R R L+R E +R
Sbjct: 194 ERQERERQERLERQERLERQERLERQERLDRERQERQERERLERLERERQ----ERERQE 249
Query: 732 LDERYHSDFNRQDR 745
ER ++ R+ R
Sbjct: 250 QLEREQLEWERERR 263
Score = 69.7 bits (169), Expect = 1e-11
Identities = 46/127 (36%), Positives = 73/127 (57%), Gaps = 6/127 (4%)
Query: 580 SGSKERASKSQDRKSASREKRSVVSFDKVKEPRKSRDSESHSRV-RERSEREQRMQAQWE 638
+G + + Q R+ ++++ + ++++ R R+ R+ RER ERE+ Q Q E
Sbjct: 133 NGPSQEELEIQRRQLQEQQRQKELERERLERERMERERLERERLERERLERERLEQEQLE 192
Query: 639 REERERLEIARERLAFQRQRLERERMER-ERLERERMHVEHERRREQERIHREREELRRQ 697
RE +ER +ERL Q + +ER+ER ERL+RER E + R ER+ RER+E RQ
Sbjct: 193 RERQERER--QERLERQERLERQERLERQERLDRERQ--ERQERERLERLERERQERERQ 248
Query: 698 QELRYEQ 704
++L EQ
Sbjct: 249 EQLEREQ 255
Score = 35.0 bits (79), Expect = 0.32
Identities = 34/118 (28%), Positives = 47/118 (39%), Gaps = 14/118 (11%)
Query: 676 VEHERRR----------EQERIHREREELRRQQELRYEQERRPAVRRPYDLDRRDDAYWP 725
+E +RR+ E+ER+ RER E R + R E+ER R + R+
Sbjct: 140 LEIQRRQLQEQQRQKELERERLERERMERERLERERLERERLERERLEQEQLERERQERE 199
Query: 726 EAKRAALDERYHSDFNRQDRFHDFDHRDRGRYPDHSVDRREGSRSMMGEREGQHYPER 783
+R ER RQ+R + DR R +R E ERE Q ER
Sbjct: 200 RQERLERQER----LERQERLERQERLDRERQERQERERLERLERERQERERQEQLER 253
>gi|39930375 enabled homolog isoform b [Homo sapiens]
Length = 570
Score = 77.4 bits (189), Expect = 6e-14
Identities = 50/134 (37%), Positives = 75/134 (55%), Gaps = 11/134 (8%)
Query: 617 SESHSRVRERSEREQRMQAQWEREERERLEIARERLAFQRQRLERERMERERLERERMHV 676
S+ ++ R +EQ+ Q + ERE ER + RERL +R+RLERER+ERERLE+E++
Sbjct: 136 SQEELEIQRRQLQEQQRQKELERERLERERMERERL--ERERLERERLERERLEQEQLER 193
Query: 677 EHERRREQERIHRE-----REELRRQQELRYEQERRPAVRRPYDLDRRDDAYWPEAKRAA 731
E + R QER+ R+ +E L RQ+ L E++ R R L+R E +R
Sbjct: 194 ERQERERQERLERQERLERQERLERQERLDRERQERQERERLERLERERQ----ERERQE 249
Query: 732 LDERYHSDFNRQDR 745
ER ++ R+ R
Sbjct: 250 QLEREQLEWERERR 263
Score = 69.7 bits (169), Expect = 1e-11
Identities = 46/127 (36%), Positives = 73/127 (57%), Gaps = 6/127 (4%)
Query: 580 SGSKERASKSQDRKSASREKRSVVSFDKVKEPRKSRDSESHSRV-RERSEREQRMQAQWE 638
+G + + Q R+ ++++ + ++++ R R+ R+ RER ERE+ Q Q E
Sbjct: 133 NGPSQEELEIQRRQLQEQQRQKELERERLERERMERERLERERLERERLERERLEQEQLE 192
Query: 639 REERERLEIARERLAFQRQRLERERMER-ERLERERMHVEHERRREQERIHREREELRRQ 697
RE +ER +ERL Q + +ER+ER ERL+RER E + R ER+ RER+E RQ
Sbjct: 193 RERQERER--QERLERQERLERQERLERQERLDRERQ--ERQERERLERLERERQERERQ 248
Query: 698 QELRYEQ 704
++L EQ
Sbjct: 249 EQLEREQ 255
Score = 35.0 bits (79), Expect = 0.32
Identities = 34/118 (28%), Positives = 47/118 (39%), Gaps = 14/118 (11%)
Query: 676 VEHERRR----------EQERIHREREELRRQQELRYEQERRPAVRRPYDLDRRDDAYWP 725
+E +RR+ E+ER+ RER E R + R E+ER R + R+
Sbjct: 140 LEIQRRQLQEQQRQKELERERLERERMERERLERERLERERLERERLEQEQLERERQERE 199
Query: 726 EAKRAALDERYHSDFNRQDRFHDFDHRDRGRYPDHSVDRREGSRSMMGEREGQHYPER 783
+R ER RQ+R + DR R +R E ERE Q ER
Sbjct: 200 RQERLERQER----LERQERLERQERLDRERQERQERERLERLERERQERERQEQLER 253
>gi|102467235 inner centromere protein antigens 135/155kDa isoform 1
[Homo sapiens]
Length = 918
Score = 77.4 bits (189), Expect = 6e-14
Identities = 63/215 (29%), Positives = 105/215 (48%), Gaps = 22/215 (10%)
Query: 509 RSTNLKRDDKCDRKDDAKKGDDGSGEKSKDQDDQKPGPSERSRATKSGSRGTERTVVMDK 568
R NL+R ++ ++ K +D K + ++ K ER R E+ + +K
Sbjct: 541 RLENLRRKEEAEQLRRQKVEED----KRRRLEEVKLKREERLRKVLQARERVEQ-MKEEK 595
Query: 569 SKGVPVISVKTSGSKERASKSQDRKSASREKRSVVSFDKVKEPRKSRDSESHSRVRERSE 628
K + + E+A + + + +++K + ++V+ RK + R ++ E
Sbjct: 596 KKQIEQKFAQIDEKTEKAKEERLAEEKAKKKAAAKKMEEVEARRKQEEEARRLRWLQQEE 655
Query: 629 REQRMQAQWER---EERERLEIARE--RLAFQRQ------------RLERERMERERLER 671
E+R Q ++ EE+ERL A E RLA QR+ R E+ER E+ER E+
Sbjct: 656 EERRHQELLQKKKEEEQERLRKAAEAKRLAEQREQERREQERREQERREQERREQERREQ 715
Query: 672 ERMHVEHERRREQERIHREREELRRQQELRYEQER 706
ER E ERRREQER+ ERE R++ LR ++E+
Sbjct: 716 ERQLAEQERRREQERLQAERELQEREKALRLQKEQ 750
Score = 62.0 bits (149), Expect = 2e-09
Identities = 56/233 (24%), Positives = 109/233 (46%), Gaps = 20/233 (8%)
Query: 509 RSTNLKRDDKCD--RKDDAKKGDDGSGEKSKDQDDQKPGPSERSRATKSGSRGTERTVVM 566
R+T L+ D KC K+ + + E+++ QK +R R + + ER
Sbjct: 522 RNTPLRMDPKCSFVEKERQRLENLRRKEEAEQLRRQKVEEDKRRRLEEVKLKREERLR-- 579
Query: 567 DKSKGVPVISVKTSGSKERASKSQDRKSASREKRSVVSFDKVKEPRKSRDSESHSRVRER 626
K ++ER + ++ K E++ +K ++ ++ R +E ++ +
Sbjct: 580 -----------KVLQARERVEQMKEEKKKQIEQKFAQIDEKTEKAKEERLAEEKAKKKAA 628
Query: 627 SEREQRMQAQWEREERER----LEIARERLAFQRQRLERERMERERLERERMHVEHERRR 682
+++ + ++A+ ++EE R L+ E Q +++ E+ERL + +R
Sbjct: 629 AKKMEEVEARRKQEEEARRLRWLQQEEEERRHQELLQKKKEEEQERLRKAAEAKRLAEQR 688
Query: 683 EQERIHREREELRRQQELRYEQERRPAVRRPYDLDRRDDAYWPEAKRAALDER 735
EQER +ER E R+++ R EQERR R+ + +RR + +A+R L ER
Sbjct: 689 EQERREQERREQERREQERREQERREQERQLAEQERRREQERLQAER-ELQER 740
Score = 50.1 bits (118), Expect = 1e-05
Identities = 49/220 (22%), Positives = 96/220 (43%), Gaps = 33/220 (15%)
Query: 479 VEKAKNEPVGKKTSDKRDSDGKKEKSSNSDRSTNLKRDDKCDRKDDAKKGDDGSGEKSKD 538
VE+ K E + D K EK+ + ++K +K AKK ++ + ++
Sbjct: 588 VEQMKEEKKKQIEQKFAQIDEKTEKAKEERLA-----EEKAKKKAAAKKMEEVEARRKQE 642
Query: 539 QDDQKPGPSERSRATKSGSRGTERTVVMDKSKGVPVISVKTSGSKERASKSQDRKSASRE 598
++ + R R + ++ K K +ER K+ + K + +
Sbjct: 643 EE------ARRLRWLQQEEEERRHQELLQKKK---------EEEQERLRKAAEAKRLAEQ 687
Query: 599 KRSVVSFDKVKEPRKSRDSESHSRVRERSEREQRMQ--AQWEREERERLEIARE------ 650
+ ++ ++ R+ ++ R RE+ REQ Q Q R E+ERL+ RE
Sbjct: 688 REQ----ERREQERREQERREQER-REQERREQERQLAEQERRREQERLQAERELQEREK 742
Query: 651 RLAFQRQRLERERMERERLERERMHVEHERRREQERIHRE 690
L Q+++L+RE E+++ E ++ E + + EQE+ +E
Sbjct: 743 ALRLQKEQLQRELEEKKKKEEQQRLAERQLQEEQEKKAKE 782
Score = 41.6 bits (96), Expect = 0.003
Identities = 48/231 (20%), Positives = 96/231 (41%), Gaps = 19/231 (8%)
Query: 485 EPVGKKTSDKRDSDGKKEKSSNSDRSTNLKRDDKCDRKDDAKKGDDGSGEKSKDQDDQKP 544
EPV + +++G N N + K A + S + + + DQ
Sbjct: 383 EPVAAAEPEVPENNGNNSWPHNDTEIANSTPNPK----PAASSPETPSAGQQEAKTDQAD 438
Query: 545 GPSERSRATKSGSRGTERTVVMDKSKGVPVISVKTSGSKERASKSQDRKSASREKRSVVS 604
GP E ++ + + +D+ + + ++ SK +S AS+ R + +
Sbjct: 439 GPREPPQSARRKRSYKQAVSELDEEQHLEDEELQPPRSKTPSSPCP----ASKVVRPLRT 494
Query: 605 F-------DKVKEPRKSRDSESHSRVRERSEREQRMQAQWEREERERLE-IARERLAFQR 656
F + P + S S ++ + + + +ER+RLE + R+ A Q
Sbjct: 495 FLHTVQRNQMLMTPTSAPRSVMKSFIKRNTPLRMDPKCSFVEKERQRLENLRRKEEAEQL 554
Query: 657 QRLERERMERERLERERMHVEHERRR---EQERIHREREELRRQQELRYEQ 704
+R + E +R RLE ++ E R+ +ER+ + +EE ++Q E ++ Q
Sbjct: 555 RRQKVEEDKRRRLEEVKLKREERLRKVLQARERVEQMKEEKKKQIEQKFAQ 605
>gi|84043963 eukaryotic translation initiation factor 5B [Homo
sapiens]
Length = 1220
Score = 77.0 bits (188), Expect = 7e-14
Identities = 96/451 (21%), Positives = 193/451 (42%), Gaps = 73/451 (16%)
Query: 281 AQSSKADSLLAVVKREPAEQPG----DGERTDCEPVGLEPAVEQSSAASELAEASSEELA 336
A +++ + A ++EP + G + ++ D + + +E+ S ++ +A E +A
Sbjct: 21 ALAAEIEGAGAAKEQEPQKSKGKKKKEKKKQDFDEDDILKELEELSLEAQGIKADRETVA 80
Query: 337 EAPTEAPSPE--ARDSK---EDGRKFDFDACNEVPPAPKESSTSEGADQKM---SSPEDD 388
PTE E ++D K + G+K FD + K+S + + A K+ S +DD
Sbjct: 81 VKPTENNEEEFTSKDKKKKGQKGKKQSFDDNDSEELEDKDSKSKKTAKPKVEMYSGSDDD 140
Query: 389 SDTKRLSKEEKGRSSCGRNFWVSGLSSTTRATDLKNLFSKYGKVVGAKVVTNARSPGARC 448
D +L K+ KG++ W + +K + S G
Sbjct: 141 DDFNKLPKKAKGKAQKSNKKWDGSEEDEDNSKKIKER-------------SRINSSG--- 184
Query: 449 YGFVTMSTAEEATKCINHLHKTELHGKMISVEKAKNEPVGKKTSDKRDSDGKKEKSSNSD 508
+ +E+ + L + + KN+P S D D +S
Sbjct: 185 ------ESGDESDEF--------LQSRKGQKKNQKNKPGPNIESGNEDDD-----ASFKI 225
Query: 509 RSTNLKRDDKCDRKDDAKKGDDGSGEKSKDQDDQKPGPSERSRATKSGSRGTERTVVMDK 568
++ K+ +K +R+ + + K K++++ + G ++S+ +S + E TV K
Sbjct: 226 KTVAQKKAEKKERERKKRDEEKAKLRKLKEKEELETGKKDQSKQKESQRKFEEETV---K 282
Query: 569 SKGVPVISVKTSGSKERAS--------KSQDRKSASREKRSVVSFDKVKEPRKSRDSESH 620
SK V V + S+E+A D+K ++K+ +K KE +K +
Sbjct: 283 SK-VTVDTGVIPASEEKAETPTAAEDDNEGDKKKKDKKKKKGEKEEKEKEKKKGPSKATV 341
Query: 621 SRVRERSEREQRMQAQWEREERERLEIARERLAFQRQRLERERMERERLERERMHVEHER 680
++E + + + + +REE ER++ + + LE +R E ERLE+E+ E ++
Sbjct: 342 KAMQEALAKLKEEEERQKREEEERIK--------RLEELEAKRKEEERLEQEKR--ERKK 391
Query: 681 RREQERIHREREELRRQQELRYEQERRPAVR 711
++E+ER +E L+++ +L + +R R
Sbjct: 392 QKEKER----KERLKKEGKLLTKSQREARAR 418
Score = 49.7 bits (117), Expect = 1e-05
Identities = 132/660 (20%), Positives = 248/660 (37%), Gaps = 96/660 (14%)
Query: 14 AGAAALSSASSETGTRRLS----DLRVIDLRAELRKRNVDSSGNKSVLMERLKKAIEDEG 69
AGAA G ++ D D+ EL + ++++ G K+ +R A++
Sbjct: 29 AGAAKEQEPQKSKGKKKKEKKKQDFDEDDILKELEELSLEAQGIKA---DRETVAVKPTE 85
Query: 70 GNPDEIEITSEGNKKTSKRSSKGRKPEEEGVEDNGLEENSGDGQEDVETSLENLQ----- 124
N E E TS+ KK KG+K +++ +DN EE + +T+ ++
Sbjct: 86 NN--EEEFTSKDKKK------KGQKGKKQSFDDNDSEELEDKDSKSKKTAKPKVEMYSGS 137
Query: 125 --DIDIMDISVLDEAEIDNGSVADCVEDDDADNLQESLSDSRELVEGEM-KELPEQLQEH 181
D D + + + + ++D DN ++ SR GE E E LQ
Sbjct: 138 DDDDDFNKLPKKAKGKAQKSNKKWDGSEEDEDNSKKIKERSRINSSGESGDESDEFLQSR 197
Query: 182 AIEDKETIN----NLDTSSSD----FTILQEIEEPSLEPENE-KILDILGETCKSEPVKE 232
+ K N N+++ + D F I ++ + + E E K D E K +KE
Sbjct: 198 KGQKKNQKNKPGPNIESGNEDDDASFKIKTVAQKKAEKKERERKKRD--EEKAKLRKLKE 255
Query: 233 ESSELEQPFAQDTSSVGPDRKLAEEEDLFDSAHPEEGDLDLASESTAHAQSSKADSLLAV 292
+ ELE +D S ++ EEE + + G + + E +++ D+
Sbjct: 256 KE-ELETG-KKDQSKQKESQRKFEEETVKSKVTVDTGVIPASEEKAETPTAAEDDNEGDK 313
Query: 293 VKREPAEQPGDGERTDCEPVGLEPAVEQSSAASELAEASSEELAEAPTEAPSPEARDSKE 352
K++ ++ G+ E + E ++ + +A E LA+ E E R +E
Sbjct: 314 KKKDKKKKKGEKEEKEKE--------KKKGPSKATVKAMQEALAKLKEE----EERQKRE 361
Query: 353 DGRKFDFDACNEVPPAPKESSTSEGADQKMSSPEDDSDTKRLSKEEKGRSSCGRNFWVSG 412
+ + E+ KE E ++ ++ +RL KE G+ S
Sbjct: 362 EEERIK--RLEELEAKRKEEERLEQEKRERKKQKEKERKERLKKE-------GKLLTKSQ 412
Query: 413 LSSTTRATDLKNLFSKYGKVVGAKVVTNARSP---GARCYGFVTMSTAEEATKCINHLHK 469
+ RA L G V +K + P + ++E ++ +
Sbjct: 413 REARARAEATLKLLQAQGVEVPSKDSLPKKRPIYEDKKRKKIPQQLESKEVSESMELCAA 472
Query: 470 TELHGKMISVEKAKNEPVGKKTSDKRDSDGKKE-KSSNSDRSTNLKRDDKC--DRKDDAK 526
E+ + + ++ PV + + + G + ++ SD T +K + K++ +
Sbjct: 473 VEVMEQGVPEKEETPPPVEPEEEEDTEDAGLDDWEAMASDEETEKVEGNKVHIEVKENPE 532
Query: 527 KGDDGSGEKSKDQDDQKPGPSERSRATKSGSRGTERTVVMDKSKGVPVISVKTSGSKERA 586
+ ++ E+ ++++D++ E GS G E
Sbjct: 533 EEEE---EEEEEEEDEESEEEEEEEGESEGSEGDE------------------------- 564
Query: 587 SKSQDRKSASREKRSVVSFDKVKEPRKSRDSESHSRVRERSEREQRMQAQWEREERERLE 646
+D K S EK S + DK S DSE S +R++ E+ R E+ RLE
Sbjct: 565 ---EDEK-VSDEKDSGKTLDKKPSKEMSSDSEYDSD-DDRTKEERAYDKAKRRIEKRRLE 619
Score = 47.8 bits (112), Expect = 5e-05
Identities = 107/596 (17%), Positives = 203/596 (34%), Gaps = 112/596 (18%)
Query: 247 SVGPDRKLAEEEDLFDSAHPEEGDLDLASESTAHAQSSKADSLLAVVKREPAEQPGDGER 306
S G +K +++D FD E+ L E + AQ KAD VK P E +
Sbjct: 40 SKGKKKKEKKKQD-FD----EDDILKELEELSLEAQGIKADRETVAVK--PTENNEEEFT 92
Query: 307 TDCEPVGLEPAVEQSSAASELAEASSEELAEAPTEAPSPEARDSKEDGRKFDFDACNEVP 366
+ + + +QS ++ E ++ T P E +D F N++P
Sbjct: 93 SKDKKKKGQKGKKQSFDDNDSEELEDKDSKSKKTAKPKVEMYSGSDDDDDF-----NKLP 147
Query: 367 PAPKESSTSEGADQKMSSPEDDSDTKRLSKEEKGRSSCGRNFWVSGLSSTTRATDLKNLF 426
K ++ +++K E+D D + KE +S G + S +R KN
Sbjct: 148 K--KAKGKAQKSNKKWDGSEEDEDNSKKIKERSRINSSGESGDESDEFLQSRKGQKKNQK 205
Query: 427 SKYGKVVGAKVVTNARSPGARCYGFVTMSTAEEATKCINHLHKTELHGKMISVEKAKNEP 486
+K G + + + T++ + K + E K+ +++ +
Sbjct: 206 NKPGPNI-----ESGNEDDDASFKIKTVAQKKAEKKERERKKRDEEKAKLRKLKEKEELE 260
Query: 487 VGKKTSDKRDSDGKK------------------EKSSNSDRSTNLKRDDKCDRKDDAKKG 528
GKK K+ +K ++ T + D++ D+K KK
Sbjct: 261 TGKKDQSKQKESQRKFEEETVKSKVTVDTGVIPASEEKAETPTAAEDDNEGDKKKKDKKK 320
Query: 529 DDGSGEKSKDQDDQKPGPSERS----RATKSGSRGTERTVVMDKSKGVPVISVKTSGSKE 584
GEK + + ++K GPS+ + + + + E ++ + + + + KE
Sbjct: 321 K--KGEKEEKEKEKKKGPSKATVKAMQEALAKLKEEEERQKREEEERIKRLEELEAKRKE 378
Query: 585 RASKSQDRKSASREKRSVVSFDKVKEPRKSRDSESHSRVR-------------------- 624
Q+++ ++K KE + S+ +R R
Sbjct: 379 EERLEQEKRERKKQKEKERKERLKKEGKLLTKSQREARARAEATLKLLQAQGVEVPSKDS 438
Query: 625 --------ERSEREQRMQAQWEREERERLEIARERLAFQRQRLERERM------------ 664
E +R++ Q +E E +E+ ++ E+E
Sbjct: 439 LPKKRPIYEDKKRKKIPQQLESKEVSESMELCAAVEVMEQGVPEKEETPPPVEPEEEEDT 498
Query: 665 ---------------ERERLERERMHVEHERRREQERIHREREELRRQQELRYEQERRPA 709
E E++E ++H+E + E+E E EE + E E+E
Sbjct: 499 EDAGLDDWEAMASDEETEKVEGNKVHIEVKENPEEEEEEEEEEEEDEESE---EEEEEEG 555
Query: 710 VRRPYDLDRRDDAYWPE-----------AKRAALDERYHSDFNRQDRFHDFDHRDR 754
+ D D+ E +K + D Y SD +R +D R
Sbjct: 556 ESEGSEGDEEDEKVSDEKDSGKTLDKKPSKEMSSDSEYDSDDDRTKEERAYDKAKR 611
Score = 47.0 bits (110), Expect = 8e-05
Identities = 70/352 (19%), Positives = 132/352 (37%), Gaps = 30/352 (8%)
Query: 64 AIEDEGGNPDEIEITSEGN-KKTSKRSSKGRKPEEEGVEDNGLEENSGDGQEDVETSLEN 122
A E++ P E +EG+ KK K+ KG K E+E + G + + ++ L+
Sbjct: 294 ASEEKAETPTAAEDDNEGDKKKKDKKKKKGEKEEKEKEKKKGPSKATVKAMQEALAKLKE 353
Query: 123 LQDIDIMD----ISVLDEAEIDNGSVADCVEDDDADNLQESLSDSRELVEGEMKELPEQL 178
++ + I L+E E + +E + + ++ + +E ++ E K L +
Sbjct: 354 EEERQKREEEERIKRLEELEAKR-KEEERLEQEKRERKKQKEKERKERLKKEGKLLTKSQ 412
Query: 179 QEHAIEDKETINNLDTSSSDFTILQEIEEPSLEPENEKILDILGETCKSEPVKEESSELE 238
+E + T+ L Q +E PS + K P+ E+ +
Sbjct: 413 REARARAEATLKLLQA--------QGVEVPSKD-----------SLPKKRPIYEDKKRKK 453
Query: 239 QPFAQDTSSVGPDRKLAEEEDLFDSAHPEEGDL--DLASESTAHAQSSKADSLLAVVKRE 296
P ++ V +L ++ + PE+ + + E + + D A+ E
Sbjct: 454 IPQQLESKEVSESMELCAAVEVMEQGVPEKEETPPPVEPEEEEDTEDAGLDDWEAMASDE 513
Query: 297 PAEQPGDGERTDCE-PVGLEPAVEQSSAASELAEASSEELAEAPTEAPSPEARDSKEDGR 355
E+ +G + E E E+ E E+ EE E +E + D K
Sbjct: 514 ETEKV-EGNKVHIEVKENPEEEEEEEEEEEEDEESEEEEEEEGESEGSEGDEEDEKVSDE 572
Query: 356 KFDFDACNEVPPAPKESSTSEGADQKMSSPEDDSDTKRLSKEEKGRSSCGRN 407
K D + P+ + SS SE + E+ + K + EK R +N
Sbjct: 573 K-DSGKTLDKKPSKEMSSDSEYDSDDDRTKEERAYDKAKRRIEKRRLEHSKN 623
>gi|224548936 hypothetical protein LOC100170229 [Homo sapiens]
Length = 715
Score = 75.9 bits (185), Expect = 2e-13
Identities = 114/504 (22%), Positives = 181/504 (35%), Gaps = 67/504 (13%)
Query: 305 ERTDCEPVGLE------PAVEQSSAASELAEASSEELAEAPTEAPSPEARD--SKEDGRK 356
ER+D +P L P +SELA S + PT PS E D S RK
Sbjct: 182 ERSDSQPRNLSKKSYRPPGGSGIGRSSELAVTPSTAKCQTPTGIPSKEKSDNPSPSSSRK 241
Query: 357 FDFDACNEVPPAPKESSTSEGADQKMSSPEDDSDTKRLSKEEKGRSSCGRNFWVSGLSST 416
+P K S +E ++ S S R + RS
Sbjct: 242 VKSYGQMIIPSREKSYSPTE-MSSRVKSYNQASTRSRPQSHSQSRSP-----------RR 289
Query: 417 TRATDLKNLFSKYGKVVGAKVVTNARSPGARCYGFVTMSTAEEATKCINHLHKTELHGKM 476
+R+ K S+ + + ARS T + + ++ H K
Sbjct: 290 SRSGSQKRTHSRVRSHSWKRNHSRARS-----------RTRKGILSQMGRHSQSRSHSKG 338
Query: 477 ISVEKAKNEPVGKKTSDKRDSDGKKEKSSNSDRSTNLKRDDKCDRKDDAKKGDDGSGEKS 536
S +++ G+ + R+ KE+S + RS++ +RD + + G SG +
Sbjct: 339 KSQNQSRTPRRGRSHNWSRNPS--KERSHSHSRSSSKERDHRGSSSPRKESGRSQSGSPN 396
Query: 537 KDQDDQKPGPSERSRATKSGSRGTERTVVMDKSKGVPVISVKTSGSKERASKSQDRKSAS 596
K +D + ++R SR D+S+ + K++DR S S
Sbjct: 397 KQRDHSRSRSPNKAR---DRSRSRSPYKARDRSRSRSPNKARDCSRSRSPYKARDR-SRS 452
Query: 597 REKRSVVSFDKVKEPRKSRDSESHSRVRERSEREQRMQAQW-----EREERERLEIARER 651
R + + P K+RD R R RS ++R +Q ER+ R ++ER
Sbjct: 453 RSPNKARDHSRSRSPNKARD-----RSRSRSPSKERDHSQLGSPSKERDHRRSRSPSKER 507
Query: 652 LAFQRQRLERERMER-------ERLERERMHVEHERRREQERIHREREELRRQQELRYEQ 704
Q + +ER R ER R+ ER R Q R E E R+ + E+
Sbjct: 508 QCRQSRSSSKERDHRRSRSPSKERQRRQSRSPNKERDRSQSRSPSEEREHRQSRSPSKER 567
Query: 705 ERRPAVRRPYDLDRRDDAYWPEAKRAALDERYHSDFNRQDRFHDFDHRDRGRYPDHSVDR 764
+RR + +RR R++ +ER HS ++ + P S
Sbjct: 568 DRRRWRSPSKERERRQ-------SRSSSEERDHSRSRSPNKQSGYSR------PRASSKE 614
Query: 765 REGSRSMMGEREGQHYPERHGGPE 788
+ SRS +EG H R E
Sbjct: 615 KAHSRSRTPSKEGNHSQSRTSSKE 638
Score = 42.7 bits (99), Expect = 0.002
Identities = 40/159 (25%), Positives = 64/159 (40%), Gaps = 15/159 (9%)
Query: 489 KKTSDKRDSDGKKEKSSNSDRSTNLKRDDKCDRKDDAKKGDDGSGEKSKDQD-DQKPGPS 547
K+ +R KE+ RS++ +RD + R ++ S +K++D Q PS
Sbjct: 493 KERDHRRSRSPSKERQCRQSRSSSKERDHRRSRSPSKERQRRQSRSPNKERDRSQSRSPS 552
Query: 548 ERSRATKSGSRGTERTVVMDKSKGVPVISVKTSGSKERASKSQDRKSASRE---KRSVVS 604
E +S S ER D+ + S SKER + S R+ RS
Sbjct: 553 EEREHRQSRSPSKER----DRRRW-------RSPSKERERRQSRSSSEERDHSRSRSPNK 601
Query: 605 FDKVKEPRKSRDSESHSRVRERSEREQRMQAQWEREERE 643
PR S ++HSR R S+ Q++ +E +
Sbjct: 602 QSGYSRPRASSKEKAHSRSRTPSKEGNHSQSRTSSKESD 640
>gi|55741709 RNA binding motif protein 25 [Homo sapiens]
Length = 843
Score = 75.1 bits (183), Expect = 3e-13
Identities = 105/439 (23%), Positives = 186/439 (42%), Gaps = 82/439 (18%)
Query: 396 KEEKGRSSCGRNFWVSGLSSTTRATDL--KNLFSKYGKVVGAKVVTNARSPGARCYGFVT 453
K ++ +CG V + + +A+D+ + L +K G V+ K V A S + +GF
Sbjct: 75 KAKENDENCGPTTTVFVGNISEKASDMLIRQLLAKCGLVLSWKRVQGA-SGKLQAFGFCE 133
Query: 454 MSTAEEATKCINHLHKTELHGKMISVEKAKNEPVGKKTSDKRDSDGKKEKSSNSD-RSTN 512
E + + LH ++ K + V+ V KT + D K+K+SN + R
Sbjct: 134 YKEPESTLRALRLLHDLQIGEKKLLVK------VDAKTKAQLDEWKAKKKASNGNARPET 187
Query: 513 LKRDDKCDRKDDAKKGD------------DGSGEKSKDQDDQKPGPSERSRATKSG---- 556
+ DD+ ++ K+ D + S E + + P ++ + K
Sbjct: 188 VTNDDEEALDEETKRRDQMIKGAIEVLIREYSSELNAPSQESDSHPRKKKKEKKEDIFRR 247
Query: 557 ------------SRGTERTVVMDKSKGVPVISVKTSGSKERASKSQDRKSASREKRSVVS 604
++ + M++ K +IS + S ++ K ++ K ++R
Sbjct: 248 FPVAPLIPYPLITKEDINAIEMEEDKR-DLISREISKFRDTHKKLEEEKGKKEKERQ--- 303
Query: 605 FDKVKEPRKSRDSESHSRVRERSEREQRMQAQWEREERERLEIARERLAFQRQRLERER- 663
++++ R+ R+ E R RER ERE+ + + ERE+ + E RER + + ER+R
Sbjct: 304 --EIEKERRERERE-RERERERREREREREREREREKEKERERERERDRDRDRTKERDRD 360
Query: 664 --------MERERL-----------------ERERMHVEHERRREQERIHREREELR-RQ 697
+RER ERER E ER RE+ER RERE R R+
Sbjct: 361 RDRERDRDRDRERSSDRNKDRSRSREKSRDRERER---ERERERERER-ERERERERERE 416
Query: 698 QELRYEQERRPAVRRPYDLDRRDDAYWPEAKRAALDERYHSDFNRQDRFHDFDHRDRGRY 757
+E E+ER +R + D +DAY L E+ + Q+R +++ R+R +
Sbjct: 417 REREREREREKDKKRDREED-EEDAYERRKLERKLREK---EAAYQERLKNWEIRERKKT 472
Query: 758 PDH--SVDRREGSRSMMGE 774
++ +R E R M +
Sbjct: 473 REYEKEAEREEERRREMAK 491
Score = 69.7 bits (169), Expect = 1e-11
Identities = 103/429 (24%), Positives = 176/429 (41%), Gaps = 84/429 (19%)
Query: 368 APKESSTSEGADQKMSSPED---DSDTKRLSKEEKGRSSCGRNFWVSGLSSTTRATDLKN 424
A K++S + +++ ++ D +TKR + KG + S L++ ++ +D
Sbjct: 174 AKKKASNGNARPETVTNDDEEALDEETKRRDQMIKGAIEVLIREYSSELNAPSQESDSHP 233
Query: 425 LFSKYGKVVGAKVVTNARSPGARCYGFVTMSTAEEATKCINHLHKTELHGKMISVEKAKN 484
K K K R P A + ++ + IN + E +IS E +K
Sbjct: 234 RKKKKEK----KEDIFRRFPVAPLIPYPLITKED-----INAIEMEEDKRDLISREISKF 284
Query: 485 EPVGKKTSDKRDSDGKKEKSSNSDRSTNLKRDDKCDRKDDAKKGDDGSGEKSKDQDDQKP 544
KK +++ GKKEK +R+ + +R+ + ++ + E+ ++++ +K
Sbjct: 285 RDTHKKLEEEK---GKKEKERQEIEKERRERERERERERERRERER-EREREREREKEKE 340
Query: 545 GPSERSRATKSGSRGTERTVVMDKSKGVPVISVKTSGSKERASKSQDRKSASREKRSVVS 604
ER R R +RT D+ + +ER +S+ R K
Sbjct: 341 RERERER-----DRDRDRTKERDRDR-----------DRERDRDRDRERSSDRNK----- 379
Query: 605 FDKVKEPRKSRDSESHSRVRERSEREQRMQAQWEREERERLEIARERLAFQRQRLERERM 664
D+ + KSRD E R RER ERE+ + + ERE E RER ERER
Sbjct: 380 -DRSRSREKSRDRE---RERER-ERERERERERERERERERERERER--------ERERE 426
Query: 665 ERERLERERMHVEHERRREQERIHRERE-------------ELRRQQELRYEQERRPAVR 711
+ ++ +RE + RR+ ER RE+E E ++ +E E ER R
Sbjct: 427 KDKKRDREEDEEDAYERRKLERKLREKEAAYQERLKNWEIRERKKTREYEKEAEREEERR 486
Query: 712 R--------------PYDLDRRDDAYWPEAKRAALDERYHSDFNRQDRFHDFDHRDRGRY 757
R YD DR D Y+ + +AL +R +++ + D RDR R
Sbjct: 487 REMAKEAKRLKEFLEDYDDDRDDPKYY---RGSALQKRLRD----REKEMEADERDRKRE 539
Query: 758 PDHSVDRRE 766
+ + R+
Sbjct: 540 KEELEEIRQ 548
Score = 65.1 bits (157), Expect = 3e-10
Identities = 47/233 (20%), Positives = 109/233 (46%), Gaps = 13/233 (5%)
Query: 483 KNEPVGKKTSDKRDSDGKKEKSSNSDRSTNLKRDDKCDRKDDAKKGDDGSGEKSKDQDDQ 542
+N+ + RD + ++E+ +R +R+ + +R+ + ++ + +K +D+++
Sbjct: 377 RNKDRSRSREKSRDREREREREREREREREREREREREREREREREREREKDKKRDREED 436
Query: 543 KPGPSERSRATKSGSRGTERTVVMDKSKGVPVISVKTSGSKERASKSQDR------KSAS 596
+ ER + + + ++ K + K + E+ ++ ++ K A
Sbjct: 437 EEDAYERRKLERKLRE--KEAAYQERLKNWEIRERKKTREYEKEAEREEERRREMAKEAK 494
Query: 597 REKRSVVSFDKVKE-PRKSRDSESHSRVRERSEREQRMQAQWEREERERLEIARERLAFQ 655
R K + +D ++ P+ R S R+R+R E+E + + E+E LE R+RL +
Sbjct: 495 RLKEFLEDYDDDRDDPKYYRGSALQKRLRDR-EKEMEADERDRKREKEELEEIRQRLLAE 553
Query: 656 RQ---RLERERMERERLERERMHVEHERRREQERIHREREELRRQQELRYEQE 705
E +RME+E R + ++ E E+E ++ +E +R++ + E+E
Sbjct: 554 GHPDPDAELQRMEQEAERRRQPQIKQEPESEEEEEEKQEKEEKREEPMEEEEE 606
Score = 63.9 bits (154), Expect = 6e-10
Identities = 70/285 (24%), Positives = 124/285 (43%), Gaps = 54/285 (18%)
Query: 480 EKAKNEPVGKKTSDKRDSDGKKEKSSNSDRSTNLKRDDKCDRKDDAKKGDDGSGEKSKDQ 539
E+ + + ++ +RD D + K + DR RD +R D K S EKS+D+
Sbjct: 332 EREREKEKERERERERDRDRDRTKERDRDRDRERDRDRDRERSSDRNKDRSRSREKSRDR 391
Query: 540 DDQKPGPSERSRATKSGSRGTERTVVMDKSKGVPVISVKTSGSKERASKSQDRKSASREK 599
+ ++ ER R R ER ++ + +ER + + K RE+
Sbjct: 392 ERERERERERER-----ERERERERERERER-----------EREREREREKDKKRDREE 435
Query: 600 RSVVSFDKVKEPRKSRDSES-------HSRVRERSE-REQRMQAQWEREERERLEIARE- 650
++++ K RK R+ E+ + +RER + RE +A EREE R E+A+E
Sbjct: 436 DEEDAYERRKLERKLREKEAAYQERLKNWEIRERKKTREYEKEA--EREEERRREMAKEA 493
Query: 651 -RL--------------------AFQRQRLERERM----ERERLERERMHVEHERRREQE 685
RL A Q++ +RE+ ER+R +RE+ +E R+R
Sbjct: 494 KRLKEFLEDYDDDRDDPKYYRGSALQKRLRDREKEMEADERDR-KREKEELEEIRQRLLA 552
Query: 686 RIHREREELRRQQELRYEQERRPAVRR-PYDLDRRDDAYWPEAKR 729
H + + ++ E E+ R+P +++ P + ++ E KR
Sbjct: 553 EGHPDPDAELQRMEQEAERRRQPQIKQEPESEEEEEEKQEKEEKR 597
>gi|239749449 PREDICTED: hypothetical protein [Homo sapiens]
Length = 275
Score = 74.7 bits (182), Expect = 4e-13
Identities = 58/209 (27%), Positives = 105/209 (50%), Gaps = 25/209 (11%)
Query: 519 CDRKDDAKKGDDGSGEKSKDQDDQKPGPSERSRATKSGSRGTERTVVMDKSKGVPVISVK 578
C +++ +K + EK K ++ +K ER + K + ER ++ +
Sbjct: 29 CTQRESERKKERREREKRK-REREKERKRERGKKEKKKRKKRERGKERERKR-------- 79
Query: 579 TSGSKERASKSQDRKSASREKRSVVSFDKVKEPRKSRDSESHSRVRERSEREQRMQAQWE 638
KER + ++R+ R KR +K K RK R + +ER ERE+ + + E
Sbjct: 80 ----KEREKQRKERREKERRKRKK---EKKKRERKQRGRRERKKKKERKERERENKQRRE 132
Query: 639 REERERLEIARERLAFQRQRLERERMERERLERERMHVEHERRREQERIHRERE---ELR 695
R+ ++R + R + +R+R E+ER +RER ++R E E++RE+ R R++E + R
Sbjct: 133 RKRKKRRKKKRRK---ERKR-EKERGKRERKRKKRKKEEREKKRERNRKERKKERERKER 188
Query: 696 RQQELRYEQERRPAVRRPYD--LDRRDDA 722
R+++ ++ERR R D DR+ D+
Sbjct: 189 RERKKERKKERRKKKERKKDRKTDRQTDS 217
Score = 72.4 bits (176), Expect = 2e-12
Identities = 61/226 (26%), Positives = 106/226 (46%), Gaps = 32/226 (14%)
Query: 490 KTSDKRDSDGKKEKSSNSDRSTNLKRDDKCDRKDDAKKGDDGSGEKSKDQDDQKPGPSER 549
K +R+S+ KKE+ R +++ K +R G EK K + ++ ER
Sbjct: 27 KPCTQRESERKKERREREKRKREREKERKRER---------GKKEKKKRKKRERGKERER 77
Query: 550 SRATKSGSRGTERTVVMDKSKGVPVISVKTSGSKERASKSQDRKSASREKRSVVSFDKVK 609
R + R R KER + +++K R++R K K
Sbjct: 78 KRKEREKQRKERR-------------------EKERRKRKKEKKKRERKQRGRRERKKKK 118
Query: 610 EPRKSRDSESHSRVRERSEREQRMQAQWEREERERLEIARERLAFQRQRLERE-RMERER 668
E RK R+ E+ R RER +++R + + + +RE+ RER +R++ ERE + ER R
Sbjct: 119 E-RKERERENKQR-RERKRKKRRKKKRRKERKREKERGKRERKRKKRKKEEREKKRERNR 176
Query: 669 LERERMHVEHERR-REQERIHREREELRRQQELRYEQERRPAVRRP 713
ER++ ERR R++ER R++ R+++ + +++ V RP
Sbjct: 177 KERKKERERKERRERKKERKKERRKKKERKKDRKTDRQTDSQVFRP 222
Score = 71.6 bits (174), Expect = 3e-12
Identities = 51/200 (25%), Positives = 104/200 (52%), Gaps = 6/200 (3%)
Query: 579 TSGSKERASKSQDRKSASREKRSVVSFDKVKEPRKSRDSESHSRVRERS--EREQRMQAQ 636
T ER + ++R+ RE+ ++ K+ +K R + RER ERE++ + +
Sbjct: 30 TQRESERKKERREREKRKREREKERKRERGKKEKKKRKKRERGKERERKRKEREKQRKER 89
Query: 637 WEREERERLEIARERLAFQRQRLERERMERERLERERMHVEHERRREQERIHREREELRR 696
E+E R+R + ++R QR R ER++ ++ER ERER + + R+ ++R ++R + R+
Sbjct: 90 REKERRKRKKEKKKRERKQRGRRERKK-KKERKERERENKQRRERKRKKRRKKKRRKERK 148
Query: 697 QQELRYEQERRPAVRRPYDLDRRDDAYWPEAKRAALDERYHSDFNRQDRFHDFDHRDRGR 756
+++ R ++ER+ R+ + +++ + E K+ ER +++R + + + R
Sbjct: 149 REKERGKRERKRKKRKKEEREKKRERNRKERKKER--ERKERRERKKERKKE-RRKKKER 205
Query: 757 YPDHSVDRREGSRSMMGERE 776
D DR+ S+ RE
Sbjct: 206 KKDRKTDRQTDSQVFRPLRE 225
Score = 64.3 bits (155), Expect = 5e-10
Identities = 56/196 (28%), Positives = 97/196 (49%), Gaps = 17/196 (8%)
Query: 602 VVSFDKVKEPRKSRDSESHSRVRERSERE-------QRMQAQWEREERERLEIARERLAF 654
+VS + +P R+SE RER +R+ +R + + E+++R++ E +ER
Sbjct: 19 MVSCSHISKPCTQRESERKKERREREKRKREREKERKRERGKKEKKKRKKRERGKER--- 75
Query: 655 QRQRLERERMERERLERERMHVEHERRREQERIHREREELRRQQELRYEQERRPAVRRPY 714
+R+R ERE+ +ER E+ER + E+++ +ER R R E ++++E R E+ER RR
Sbjct: 76 ERKRKEREKQRKERREKERRKRKKEKKK-RERKQRGRRERKKKKE-RKERERENKQRRER 133
Query: 715 D-LDRRDDAYWPEAKRAALDERYHSDFNRQDRFHDFDHRDRGRYPDHSVDRREGSRSMMG 773
RR E KR E+ R+ + + R++ R + ++E R
Sbjct: 134 KRKKRRKKKRRKERKR----EKERGKRERKRKKRKKEEREKKRERNRKERKKERERKERR 189
Query: 774 EREGQHYPERHGGPER 789
ER+ + ER ER
Sbjct: 190 ERKKERKKERRKKKER 205
Score = 35.8 bits (81), Expect = 0.19
Identities = 34/157 (21%), Positives = 62/157 (39%), Gaps = 6/157 (3%)
Query: 469 KTELHGKMISVEKAKNEPVGKKTSDKRDSDGKKEKSSNSDRSTNLKRDDKCDRKDDAKKG 528
K GK ++ + E K+ +K KKEK + + K + + ++
Sbjct: 67 KKRERGKERERKRKEREKQRKERREKERRKRKKEKKKRERKQRGRRERKKKKERKERERE 126
Query: 529 DDGSGEKSKDQDDQKPGPSERSRATKSGSRGTERTVVMDKSKGVPVISVKTSGSKERASK 588
+ E+ + + +K ER R + G R +R K K + KER +
Sbjct: 127 NKQRRERKRKKRRKKKRRKERKREKERGKRERKR----KKRKKEEREKKRERNRKERKKE 182
Query: 589 SQDRKSASREKRSVVSFDKVKEPRKSR--DSESHSRV 623
+ ++ R+K K KE +K R D ++ S+V
Sbjct: 183 RERKERRERKKERKKERRKKKERKKDRKTDRQTDSQV 219
Score = 31.6 bits (70), Expect = 3.5
Identities = 32/152 (21%), Positives = 60/152 (39%), Gaps = 12/152 (7%)
Query: 648 ARERLAFQRQRLERERMERERLERERMHVEHERRREQERIHRERE----------ELRRQ 697
A +L + Q + + + +RE + R RE+ + RE+E + R++
Sbjct: 9 AAVKLNTELQMVSCSHISKPCTQRESERKKERREREKRKREREKERKRERGKKEKKKRKK 68
Query: 698 QELRYEQERRPAVRRPYDLDRRDDAYWPEAKRAALDERYHSDFNRQDRFHDFDHRDRGRY 757
+E E+ER+ R +RR+ K ER R++R + ++R R
Sbjct: 69 RERGKERERKRKEREKQRKERREKERRKRKKEKKKRER--KQRGRRERKKKKERKERERE 126
Query: 758 PDHSVDRREGSRSMMGEREGQHYPERHGGPER 789
+R+ R R+ + + G ER
Sbjct: 127 NKQRRERKRKKRRKKKRRKERKREKERGKRER 158
Score = 31.6 bits (70), Expect = 3.5
Identities = 17/78 (21%), Positives = 36/78 (46%)
Query: 480 EKAKNEPVGKKTSDKRDSDGKKEKSSNSDRSTNLKRDDKCDRKDDAKKGDDGSGEKSKDQ 539
EK + + K+ K++ KK + + +R +R ++ +RK + KK E+ KD+
Sbjct: 150 EKERGKRERKRKKRKKEEREKKRERNRKERKKERERKERRERKKERKKERRKKKERKKDR 209
Query: 540 DDQKPGPSERSRATKSGS 557
+ S+ R + +
Sbjct: 210 KTDRQTDSQVFRPLRESA 227
>gi|32483416 neurofilament, heavy polypeptide 200kDa [Homo sapiens]
Length = 1020
Score = 73.9 bits (180), Expect = 6e-13
Identities = 157/783 (20%), Positives = 302/783 (38%), Gaps = 104/783 (13%)
Query: 1 MAETLSGLGDSGAAGAAALSSASSETGTRRLSDLRVIDLRAELRKRNVDSS-GNKSVLME 59
+ E L + SGAA A + S LR ++RA+L V S+ ++
Sbjct: 238 VGELLGQIQGSGAAQAQMQAETRDALKCDVTSALR--EIRAQLEGHAVQSTLQSEEWFRV 295
Query: 60 RLKKAIEDEGGNPDEIEITSEGNKKTSKRSSKGRKPEEEGVEDNGLEENSGDGQEDVETS 119
RL + E N D + E + +R + R E E ++ ++ D E +
Sbjct: 296 RLDRLSEAAKVNTDAMRSAQEEITEY-RRQLQARTTELEALK------STKDSLERQRSE 348
Query: 120 LENLQDIDIMD----ISVLDEAEIDNGS---VADCVEDDDADNLQESLSDS----RELVE 168
LE+ DI I LD AE+ N A E D N++ +L R+L+E
Sbjct: 349 LEDRHQADIASYQEAIQQLD-AELRNTKWEMAAQLREYQDLLNVKMALDIEIAAYRKLLE 407
Query: 169 GE----------------MKELPEQLQEHAIEDKETINNLDTSSSDFTILQEIEEPSLEP 212
GE + ++P ++ +E I ++ S + I++E +
Sbjct: 408 GEECRIGFGPIPFSLPEGLPKIPSVSTHIKVKSEEKIKVVEKSEKETVIVEE------QT 461
Query: 213 ENEKILDILGETCKSEPVKEESSELEQPFAQDTSSVGPDRKLAEEEDLFDSAHPEEGDLD 272
E ++ + + E + E +EE E E ++ + K E+ + +
Sbjct: 462 EETQVTEEVTEEEEKEAKEEEGKEEEGGEEEEAEGGEEETKSPPAEEAASPEKEAKSPVK 521
Query: 273 LASESTAHAQS---SKADSLLAVVKREPAEQPGDGERTDCEPVGLEPAVEQSSAASEL-- 327
++S A A+S +A S V E A+ P E P P E++ + +E+
Sbjct: 522 EEAKSPAEAKSPEKEEAKSPAEVKSPEKAKSPAK-EEAKSPPEAKSPEKEEAKSPAEVKS 580
Query: 328 ---AEASSEELAEAPTEAPSPEARDS--KEDGRKFDFDACNEVPPAPKESSTSEGADQ-- 380
A++ ++E A++P EA SPE S KE+ + PA +S E A
Sbjct: 581 PEKAKSPAKEEAKSPAEAKSPEKAKSPVKEEAKS----------PAEAKSPVKEEAKSPA 630
Query: 381 KMSSPEDDSDTKRLSKEEKGRSSCGRNFWVSGLSSTTRATDLKNLFSKYGKVVGAKVVTN 440
++ SPE K +KEE ++ S +A +K + + V
Sbjct: 631 EVKSPEK---AKSPTKEEAKSPEKAKSPEKEEAKSPEKAKSPVKAEAKSPEKAKSPVKAE 687
Query: 441 ARSPG-ARCYGFVTMSTAEEATKCINHLHKTELHGKMISVEKAKNEPVGKKTSDKRDSDG 499
A+SP A+ + E+A + K+ K E+AK K +
Sbjct: 688 AKSPEKAKSPVKEEAKSPEKAKSPVKEEAKSPEKAKSPVKEEAKTPEKAKSPVKEEAKSP 747
Query: 500 KKEKSSNSDRSTNLKRDD-KCDRKDDAKKGDDGSGEKSKDQ-DDQKPGPSERSRATKSGS 557
+K KS ++ ++K + K K++A+ D EK+K ++ P + K +
Sbjct: 748 EKAKSPEKAKTLDVKSPEAKTPAKEEARSPADKFPEKAKSPVKEEVKSPEKAKSPLKEDA 807
Query: 558 RGTERTVVMDKSKGVPV--------ISVKTSGSK---ERAS---KSQDRKSASREKRSVV 603
+ E+ + + PV + VK K E+A K++++K + +E+
Sbjct: 808 KAPEKEIPKKEEVKSPVKEEEKPQEVKVKEPPKKAEEEKAPATPKTEEKKDSKKEEAPKK 867
Query: 604 SFDKVK-----EPRKSRDSESHSRVRERSEREQRMQAQWEREERERLEIARERLAFQRQR 658
K K EP + ES ++ +++ E+E ++E+
Sbjct: 868 EAPKPKVEEKKEPAVEKPKESKVEAKKEEAEDKKKVPTPEKEAPAKVEV----------- 916
Query: 659 LERERMERERLERERMHVEHERRREQERIHREREELRRQQELRYEQERRPAVRRPYDLDR 718
+ + +E+ E + + + +E + ++E +++ + E+ ++P + +
Sbjct: 917 -KEDAKPKEKTEVAKKEPDDAKAKEPSKPAEKKEAAPEKKDTKEEKAKKPEEKPKTEAKA 975
Query: 719 RDD 721
++D
Sbjct: 976 KED 978
Score = 70.5 bits (171), Expect = 7e-12
Identities = 128/606 (21%), Positives = 228/606 (37%), Gaps = 71/606 (11%)
Query: 37 IDLRAELRKRNVDSSGNKSVLMERLKKAIEDEGGNPDEIEITSEGNKKTSKRSSKGRKPE 96
I +++E + + V+ S ++V++E +E ++T E ++ K + E
Sbjct: 436 IKVKSEEKIKVVEKSEKETVIVEE----------QTEETQVTEEVTEEEEKEAK-----E 480
Query: 97 EEGVEDNGLEENSGDGQEDVETS--LENLQDIDIMDISVLDEAEIDNGSVADCVEDDDAD 154
EEG E+ G EE +G E+ S E + S + E E + + A E ++A
Sbjct: 481 EEGKEEEGGEEEEAEGGEEETKSPPAEEAASPEKEAKSPVKE-EAKSPAEAKSPEKEEAK 539
Query: 155 NLQE--SLSDSRELVEGEMKELPEQLQEHAIEDKETINNLDTSSSDFTILQEIEEPSLEP 212
+ E S ++ + E K PE E K + +E + P+
Sbjct: 540 SPAEVKSPEKAKSPAKEEAKSPPEAKSPEKEEAKSPAEVKSPEKAKSPAKEEAKSPAEAK 599
Query: 213 ENEKILDILGETCKS-----EPVKEES---SELEQPFAQDTSSVGPDRKLAEEEDLFDSA 264
EK + E KS PVKEE+ +E++ P + P ++ A+ + S
Sbjct: 600 SPEKAKSPVKEEAKSPAEAKSPVKEEAKSPAEVKSP----EKAKSPTKEEAKSPEKAKSP 655
Query: 265 HPEEGDLDLASESTAHAQSSKADSLLAVVKRE---------PAEQPGDGERTDCEPVGLE 315
EE ++S A++ + + VK E P ++ PV E
Sbjct: 656 EKEEAKSPEKAKSPVKAEAKSPEKAKSPVKAEAKSPEKAKSPVKEEAKSPEKAKSPVKEE 715
Query: 316 PAVEQSSAASELAEASSEELAEAPT--EAPSPEARDSKEDGRKFDFDACNEVPPAPKES- 372
+ + + EA + E A++P EA SPE S E + D + PA +E+
Sbjct: 716 AKSPEKAKSPVKEEAKTPEKAKSPVKEEAKSPEKAKSPEKAKTLDVKSPEAKTPAKEEAR 775
Query: 373 STSEGADQKMSSPEDDSDTKRLSKEEKGRSSCGRNFWVSGLSSTTRATDLKNLFSKYGKV 432
S ++ +K SP + + EK +S + + ++K+ + K
Sbjct: 776 SPADKFPEKAKSPVKEE----VKSPEKAKSPLKEDAKAPE-KEIPKKEEVKSPVKEEEKP 830
Query: 433 VGAKV------VTNARSPGARCYGFVTMSTAEEATKCINHLHKTELHGKMISVEKAKNEP 486
KV ++P S EEA K K E K +VEK K
Sbjct: 831 QEVKVKEPPKKAEEEKAPATPKTEEKKDSKKEEAPKKEAPKPKVE-EKKEPAVEKPKESK 889
Query: 487 VGKKTSDKRDSDGKKEKSSNSDRSTNLKRDDKCDRKDD-AKKGDDGSGEKS--------- 536
V K + D + +K D K K + AKK D + K
Sbjct: 890 VEAKKEEAEDKKKVPTPEKEAPAKVEVKEDAKPKEKTEVAKKEPDDAKAKEPSKPAEKKE 949
Query: 537 -----KDQDDQKPGPSERSRATKSGSRGTERTVVMDKSKGVPVISVKTSGSKERASKSQD 591
KD ++K E T++ ++ ++T+ + SK + K+S + ++ SK +
Sbjct: 950 AAPEKKDTKEEKAKKPEEKPKTEAKAKEDDKTLSKEPSKPKAEKAEKSSSTDQKDSKPPE 1009
Query: 592 RKSASR 597
+ + +
Sbjct: 1010 KATEDK 1015
Score = 48.9 bits (115), Expect = 2e-05
Identities = 68/341 (19%), Positives = 129/341 (37%), Gaps = 17/341 (4%)
Query: 59 ERLKKAIEDEGGNPDEIEITSEGNKKTSKRSSKGRKPEEEGVEDNGLEENSGDGQEDVET 118
E+ K +++E +P++ + + K+ +++ K E + E +
Sbjct: 692 EKAKSPVKEEAKSPEKAKSPVKEEAKSPEKAKSPVKEEAKTPEKAKSPVKEEAKSPEKAK 751
Query: 119 SLENLQDIDIMDISVLDEAEIDNGSVADCVEDDDADNLQESLSDSRELVEGEMKELPEQL 178
S E + +D+ A+ + S AD + ++E + S E + +KE +
Sbjct: 752 SPEKAKTLDVKSPEAKTPAKEEARSPADKFPEKAKSPVKEEVK-SPEKAKSPLKE-DAKA 809
Query: 179 QEHAIEDKETINNLDTSSSDFTILQEIEEPSLEPENEKILDILGETCKSEPVKEESSELE 238
E I KE + + + +++EP + E EK K + KEE+ + E
Sbjct: 810 PEKEIPKKEEVKS-PVKEEEKPQEVKVKEPPKKAEEEKAPATPKTEEKKDSKKEEAPKKE 868
Query: 239 QPFAQDTSSVGPDRKLAEEEDLFDSAHPEEGDLDLASESTAHAQSSKADSLLAVVKREPA 298
P + EE+ P+E ++ E + A K E
Sbjct: 869 AP-----------KPKVEEKKEPAVEKPKESKVEAKKEEAEDKKKVPTPEKEAPAKVEVK 917
Query: 299 EQPGDGERTDCEPVGLEPA-VEQSSAASELAEASSEELAEAPTEAPSPEARDSKEDGRKF 357
E E+T+ + A ++ S +E EA+ E+ +A PE + E K
Sbjct: 918 EDAKPKEKTEVAKKEPDDAKAKEPSKPAEKKEAAPEKKDTKEEKAKKPEEKPKTEAKAKE 977
Query: 358 DFDACNEVPPAPK--ESSTSEGADQKMSSPEDDSDTKRLSK 396
D ++ P PK ++ S DQK S P + + + +K
Sbjct: 978 DDKTLSKEPSKPKAEKAEKSSSTDQKDSKPPEKATEDKAAK 1018
>gi|4503509 eukaryotic translation initiation factor 3, subunit 10
theta, 150/170kDa [Homo sapiens]
Length = 1382
Score = 73.2 bits (178), Expect = 1e-12
Identities = 82/320 (25%), Positives = 128/320 (40%), Gaps = 51/320 (15%)
Query: 582 SKERASKSQDRKSASREKRSVVSFDKVKEPRKSRDSESHSRVRERSEREQRMQAQWEREE 641
++ER ++ ++RK +E+R + + + +E + R E ++ER ERE+ +A+ E E
Sbjct: 784 AEERHNRLEERKRQRKEERRITYYREKEEEEQRRAEEQ--MLKEREERERAERAKREEEL 841
Query: 642 RERLEIARERLAFQRQRLERERMERERLERERMHVEHERRREQERIHREREELRRQQELR 701
RE +Q + + E +ER++ +RE E ERRRE+ER L R+
Sbjct: 842 RE----------YQERVKKLEEVERKKRQRELEIEERERRREEER-RLGDSSLSRKDSRW 890
Query: 702 YEQERRPAVRRPYDLDRR-----DDAYWPEAKRAALDERYHSDFNRQDRFHDFDHRDRGR 756
+++ R+ + D + W + D + D R R D + R+
Sbjct: 891 GDRDSEGTWRKGPEADSEWRRGPPEKEWRRGEGRDEDRSHRRDEERPRRLGDDEDREPSL 950
Query: 757 YPDHSVDRREGSRSMMGEREGQHYPERHGGPERHGRDSRDGWGGYGSDKRMSEGRGLPPP 816
PD D R R M +R + PE R D R W D+ P
Sbjct: 951 RPD---DDRVPRRGMDDDRGPRRGPEEDRFSRRGADDDRPSWRNTDDDR----------P 997
Query: 817 PRR----DWGDHGRREDDRSWQGTADGGMMDRDHKRW------QGGERSMSGHSGPGHMM 866
PRR D G+ +DDR + +D D W +G R M GP
Sbjct: 998 PRRIADEDRGNWRHADDDRPPRRG-----LDEDRGSWRTADEDRGPRRGMDDDRGP---- 1048
Query: 867 NRGGMSG-RGSFAPGGASRG 885
RGG R S+ RG
Sbjct: 1049 RRGGADDERSSWRNADDDRG 1068
Score = 72.0 bits (175), Expect = 2e-12
Identities = 94/364 (25%), Positives = 144/364 (39%), Gaps = 35/364 (9%)
Query: 567 DKSKGVPVISVKTSGSKERASKSQDRKSASREKRSVVSFDKVKEPRKSRDSESHSRVRER 626
+++K + I + S +E+ K D E+R + + +E + + +R
Sbjct: 699 ERAKRLEEIPLIKSAYEEQRIKDMDLWEQQEEER-ITTMQLEREKALEHKNRMSRMLEDR 757
Query: 627 SEREQRMQAQWEREERERLEIARERLAFQR-QRLE---RERMERERLERERMHVEHERRR 682
R++A + E+L+ ERLA +R RLE R+R E R+ R E E+RR
Sbjct: 758 DLFVMRLKAARQSVYEEKLKQFEERLAEERHNRLEERKRQRKEERRITYYREKEEEEQRR 817
Query: 683 EQERIHREREE------LRRQQELRYEQERRPAVRRPYDLDRRDDAYWPEAKRAALDERY 736
+E++ +EREE +R++ELR QER + R+ + E +R +ER
Sbjct: 818 AEEQMLKEREERERAERAKREEELREYQERVKKLEEVERKKRQRELEIEERERRREEERR 877
Query: 737 --HSDFNRQD-RFHDFDHRDRGRY------------PDHSVDRREGSRSMMGEREGQHYP 781
S +R+D R+ D D R P+ R EG R + P
Sbjct: 878 LGDSSLSRKDSRWGDRDSEGTWRKGPEADSEWRRGPPEKEWRRGEGRDEDRSHRRDEERP 937
Query: 782 ERHGGPERHGRDSRDGWGGYGSDKRMSEGRGLPPPPRRDWGDHGRREDDR-SWQGTADGG 840
R G E R + M + RG P D +DDR SW+ T D
Sbjct: 938 RRLGDDEDREPSLRPD-DDRVPRRGMDDDRGPRRGPEEDRFSRRGADDDRPSWRNTDD-- 994
Query: 841 MMDRDHKRWQGGERSMSGHSGPGHMMNRGGMSGRGSFAPGGASRGHPIPHGGMQGGFGGQ 900
DR +R +R H+ RG RGS+ RG P GM G +
Sbjct: 995 --DRPPRRIADEDRGNWRHADDDRPPRRGLDEDRGSWRTADEDRG---PRRGMDDDRGPR 1049
Query: 901 SRGS 904
G+
Sbjct: 1050 RGGA 1053
Score = 57.4 bits (137), Expect = 6e-08
Identities = 82/377 (21%), Positives = 161/377 (42%), Gaps = 43/377 (11%)
Query: 482 AKNEPVGKKTSDKRDSDGKKEKSSNSDRSTNLKRDDKCDRKDDAKKGDDGSGEKSKDQDD 541
A+ + + ++ + ++EK R L++ K + + ++ + E+ + +
Sbjct: 570 ARRQTIEERKERLESLNIQREKEELEQREAELQKVRKAEEERLRQEAKEREKERILQEHE 629
Query: 542 QKPGPSERSRA-----TKSGSRGTERTVVMDKSKGVP-VISVKTSGSKERASKSQDRKSA 595
Q + R R T+ G++ + + D + P I K E+ K +
Sbjct: 630 QIKKKTVRERLEQIKKTELGAKAFKDIDIEDLEELDPDFIMAKQVEQLEKEKKELQERLK 689
Query: 596 SREKRSVVSFDKVKEPRKSRDSESHSRVRERSEREQRMQAQ--WEREERERL---EIARE 650
++EK+ + F++ K E ++ E EQR++ WE++E ER+ ++ RE
Sbjct: 690 NQEKK-IDYFERAKR------LEEIPLIKSAYE-EQRIKDMDLWEQQEEERITTMQLERE 741
Query: 651 RLAFQRQRLERERMERE----RLERERMHVEHERRRE-QERIHREREELRRQQELRYEQE 705
+ + R+ R +R+ RL+ R V E+ ++ +ER+ ER +++ + ++E
Sbjct: 742 KALEHKNRMSRMLEDRDLFVMRLKAARQSVYEEKLKQFEERLAEERHNRLEERKRQRKEE 801
Query: 706 RRPAVRRPYDLDRRDDAYWPEAKRAALDERYHSDFNRQDRFHDFDHRDRGRYPDHSVDRR 765
RR R + + + A K ER R++ ++ R + V+R+
Sbjct: 802 RRITYYREKEEEEQRRAEEQMLKEREERERAER-AKREEELREYQERVKKL---EEVERK 857
Query: 766 EGSRSM-MGEREGQHYPERHGGPERHGR-DSRDGWGGYGSDKRMSEG--------RGLPP 815
+ R + + ERE + ER G R DSR WG S+ +G RG
Sbjct: 858 KRQRELEIEERERRREEERRLGDSSLSRKDSR--WGDRDSEGTWRKGPEADSEWRRG--- 912
Query: 816 PPRRDWGDHGRREDDRS 832
PP ++W R++DRS
Sbjct: 913 PPEKEWRRGEGRDEDRS 929
Score = 53.1 bits (126), Expect = 1e-06
Identities = 72/307 (23%), Positives = 119/307 (38%), Gaps = 37/307 (12%)
Query: 496 DSDGKKEKSSNSDRSTNLKRDDKCDRKDDAKKGDDGSGEKSKDQDDQKPGPSERSRATKS 555
D D + + DR DD DR DD ++ D DD+ ++ R +
Sbjct: 1104 DDDRGPRRGLDDDRGPWRNADD--DRIPRRGAEDDRGPWRNMD-DDRLSRRADDDRFPRR 1160
Query: 556 GSRGTERTVVMDKSKGVPVISVKTSGSKERASKSQDRKSASREKRSVVSFDKVKEPRKSR 615
G D G VK G +E+ ++ RE R + +E + R
Sbjct: 1161 GD---------DSRPGPWRPLVKPGGWREKEKAREESWGPPRESRPSEEREWDREKERDR 1211
Query: 616 DSESHSRVRERSEREQRMQAQWEREERERLEIARERLAFQRQRLERERMERERLERERMH 675
D++ + ERE+ + +RE+R R R+ ++R E R+ R+
Sbjct: 1212 DNQDREENDKDPERERDRERDVDREDRFRR--PRDEGGWRRGPAEESSSWRDSSRRDDRD 1269
Query: 676 VEHERRREQERIHREREELRRQQELRYEQERRPAVRRPYDLDRRDDAYWPEAKRAALDER 735
+RRRE++ +R +LR +++LR +++RR P +R + + W A
Sbjct: 1270 -RDDRRRERD----DRRDLRERRDLRDDRDRRGP---PLRSEREEVSSWRRA-------- 1313
Query: 736 YHSDFNRQDRFHDFDHRDRGRYPDHSVDR-REGSRSMMGEREGQHY---PERHGGPERHG 791
D + DR + D R P S DR R+ R GE+E + +R
Sbjct: 1314 ---DDRKDDRVEERDPPRRVPPPALSRDRERDRDREREGEKEKASWRAEKDRESLRRTKN 1370
Query: 792 RDSRDGW 798
DGW
Sbjct: 1371 ETDEDGW 1377
Score = 47.4 bits (111), Expect = 6e-05
Identities = 61/232 (26%), Positives = 97/232 (41%), Gaps = 61/232 (26%)
Query: 480 EKAKNEPVG----KKTSDKRDSDGKKEKS-SNSDRSTNLK-------RDDKCDRKDDAKK 527
EKA+ E G + S++R+ D +KE+ N DR N K R+ DR+D +
Sbjct: 1182 EKAREESWGPPRESRPSEEREWDREKERDRDNQDREENDKDPERERDRERDVDREDRFR- 1240
Query: 528 GDDGSGEKSKDQDDQKPGPSERSRATKSGSRGTERTVVMDKSKGVPVISVKTSGSKERAS 587
+ +D+ + GP+E S + + SR R
Sbjct: 1241 -------RPRDEGGWRRGPAEESSSWRDSSR--------------------------RDD 1267
Query: 588 KSQDRKSASREKRSVVSFDKVKEPRKSRDSESHSRVRERSEREQRMQAQWEREERERLEI 647
+ +D + R+ R ++E R RD RSERE+ + W R + + +
Sbjct: 1268 RDRDDRRRERDDRR-----DLRERRDLRDDRDRRGPPLRSEREE--VSSWRRADDRKDDR 1320
Query: 648 ARERLAFQR---QRLERERMERERLERERMHVEHERRREQERIHREREELRR 696
ER +R L R+R ER+R +RER E E+ + R ++RE LRR
Sbjct: 1321 VEERDPPRRVPPPALSRDR-ERDR-DRER---EGEKEKASWRAEKDRESLRR 1367
Score = 43.1 bits (100), Expect = 0.001
Identities = 27/109 (24%), Positives = 54/109 (49%), Gaps = 4/109 (3%)
Query: 592 RKSASREKRSVVSFDKVKEPRKSRDSESHSRVRERSEREQRMQAQWEREERERLEIARER 651
++ + + +V ++ K R + ER ER + + Q E+EE E+ E ++
Sbjct: 544 QEKEEQHQLAVTAYLKNSRKEHQRILARRQTIEERKERLESLNIQREKEELEQREAELQK 603
Query: 652 LAFQRQRLERERMERERLERERMHVEHERRREQERIHREREELRRQQEL 700
+ ++ E ER+ +E ERE+ + E + +++ RER E ++ EL
Sbjct: 604 V----RKAEEERLRQEAKEREKERILQEHEQIKKKTVRERLEQIKKTEL 648
Score = 37.4 bits (85), Expect = 0.064
Identities = 23/86 (26%), Positives = 47/86 (54%), Gaps = 7/86 (8%)
Query: 623 VRERSEREQRMQAQWEREERERLEIARERLAFQRQRLE--RERMERERLERERMHVEHER 680
++E+ E+ Q + + R+ +R+ +RQ +E +ER+E ++RE+ +E +R
Sbjct: 543 LQEKEEQHQLAVTAYLKNSRKE----HQRILARRQTIEERKERLESLNIQREKEELE-QR 597
Query: 681 RREQERIHREREELRRQQELRYEQER 706
E +++ + EE RQ+ E+ER
Sbjct: 598 EAELQKVRKAEEERLRQEAKEREKER 623
Score = 36.6 bits (83), Expect = 0.11
Identities = 24/94 (25%), Positives = 43/94 (45%), Gaps = 4/94 (4%)
Query: 618 ESHSRVRERSEREQRMQAQWEREERERLEIARERLAFQRQRLERERMERERLERERMHVE 677
E H + R + Q R+ +E +ERL + E+E +E+ E +++
Sbjct: 548 EQHQLAVTAYLKNSRKEHQRILARRQTIEERKERLESLNIQREKEELEQREAELQKVRKA 607
Query: 678 HERRREQERIHREREELRRQQELRYEQERRPAVR 711
E R QE RE+E + ++ +EQ ++ VR
Sbjct: 608 EEERLRQEAKEREKERILQE----HEQIKKKTVR 637
Score = 36.6 bits (83), Expect = 0.11
Identities = 96/407 (23%), Positives = 146/407 (35%), Gaps = 78/407 (19%)
Query: 488 GKKTSDKRDSDGKKE-KSSNSDRSTNLKRDDKCDRKDDAKKGDDGSGEKSKDQDDQKP-- 544
G + R +G+ E +S D + D DR+ + DD + D DD+ P
Sbjct: 912 GPPEKEWRRGEGRDEDRSHRRDEERPRRLGDDEDREPSLRPDDDRVPRRGMD-DDRGPRR 970
Query: 545 GPSER--SRATKSGSRGTERTVVMDKSKGVPVISVKTSGSKERASKSQD-RKSASREKRS 601
GP E SR R + R D + I+ + G+ A + R+ ++ S
Sbjct: 971 GPEEDRFSRRGADDDRPSWRNT--DDDRPPRRIADEDRGNWRHADDDRPPRRGLDEDRGS 1028
Query: 602 VVSFDKVKEPRKSRDSESHSRVRERSEREQRMQAQWEREERERLEIARERLAFQRQRLER 661
+ D+ + PR+ D + R R ++ E+ + W + +R R R R
Sbjct: 1029 WRTADEDRGPRRGMDDDRGPR-RGGADDER---SSWRNADDDR----GPRRGLDDDRGPR 1080
Query: 662 ERMERERLERERMHVEHERRREQERIHREREELRRQQELRYEQERRPAVRRPYDLDR--- 718
M+ +R R M + RR + +R P RR D DR
Sbjct: 1081 RGMDDDRGPRRGMDDDRGPRRGMD------------------DDRGP--RRGLDDDRGPW 1120
Query: 719 --RDDAYWPEAKRAALDER---YHSDFNRQDRFHDFDHRDRGRYPDHSVDRREGSRSMM- 772
DD P +R A D+R + D +R R D D R+P D R G +
Sbjct: 1121 RNADDDRIP--RRGAEDDRGPWRNMDDDRLSRRADDD-----RFPRRGDDSRPGPWRPLV 1173
Query: 773 ---GEREGQHYPERHGGPERHGRDS------------RDGWGGYGSDKRMSEGRGLPPP- 816
G RE + E GP R R S RD +DK R
Sbjct: 1174 KPGGWREKEKAREESWGPPRESRPSEEREWDREKERDRDNQDREENDKDPERERDRERDV 1233
Query: 817 --------PRRDWG-DHGRREDDRSWQGTADGGMMDRDHKRWQGGER 854
PR + G G E+ SW+ ++ DRD +R + +R
Sbjct: 1234 DREDRFRRPRDEGGWRRGPAEESSSWRDSSRRDDRDRDDRRRERDDR 1280
Score = 31.2 bits (69), Expect = 4.6
Identities = 84/387 (21%), Positives = 148/387 (38%), Gaps = 64/387 (16%)
Query: 62 KKAIEDEGGNPDEIEITSEGNKKTSKRSS--KGRKPEEEGVEDNG--------LEENSGD 111
++ IE+ + + I E + + + K RK EEE + L+E+
Sbjct: 572 RQTIEERKERLESLNIQREKEELEQREAELQKVRKAEEERLRQEAKEREKERILQEHEQI 631
Query: 112 GQEDVETSLENLQ----------DIDIMDISVLDEAEIDNGSVADCVEDDDADNLQESLS 161
++ V LE ++ DIDI D+ LD I V + + LQE L
Sbjct: 632 KKKTVRERLEQIKKTELGAKAFKDIDIEDLEELDPDFIMAKQVEQL--EKEKKELQERLK 689
Query: 162 DSRELVE-----GEMKELP---EQLQEHAIEDKETINNLDTSSSDFTILQEIEEPSLEPE 213
+ + ++ ++E+P +E I+D + + T +Q E +LE +
Sbjct: 690 NQEKKIDYFERAKRLEEIPLIKSAYEEQRIKDMDLWEQQEEER--ITTMQLEREKALEHK 747
Query: 214 N-------EKILDILGETCKSEPVKEES-SELEQPFAQDTSSVGPDRKLAEEEDLFDSAH 265
N ++ L ++ + V EE + E+ A++ + +RK +E+ + +
Sbjct: 748 NRMSRMLEDRDLFVMRLKAARQSVYEEKLKQFEERLAEERHNRLEERKRQRKEERRITYY 807
Query: 266 PEEGDLDLASESTAHAQSSKADSLLAVVKREPAEQPGDGE--RTDCEPVGLEPAVEQSSA 323
E+ + + + A Q K +RE AE+ E R E V VE+
Sbjct: 808 REKEEEE---QRRAEEQMLKERE-----ERERAERAKREEELREYQERVKKLEEVERKKR 859
Query: 324 ASELAEASSEELAEAPTEAPSPEARDSKEDGRKFDFDA---CNEVP---------PAPKE 371
EL E E E ++ S++D R D D+ + P P KE
Sbjct: 860 QRELEIEERERRREE--ERRLGDSSLSRKDSRWGDRDSEGTWRKGPEADSEWRRGPPEKE 917
Query: 372 SSTSEGADQKMSSPEDDSDTKRLSKEE 398
EG D+ S D+ +RL +E
Sbjct: 918 WRRGEGRDEDRSHRRDEERPRRLGDDE 944
>gi|44680105 caldesmon 1 isoform 1 [Homo sapiens]
Length = 793
Score = 72.4 bits (176), Expect = 2e-12
Identities = 65/279 (23%), Positives = 121/279 (43%), Gaps = 40/279 (14%)
Query: 481 KAKNEPVGKKTSDKRD-SDGKKEKSSNSDRSTNLKRDDKCDRKDDAKKGDDGSGEKSKDQ 539
+ +N+ +T++K + S+ ++E+ + T K K D +D E++K +
Sbjct: 136 RMQNDTAENETTEKEEKSESRQERYEIEETETVTKSYQKNDWRD---------AEENKKE 186
Query: 540 DDQKPGPSERSRATKSGSRGTERTVVMDKSKGVPVISVKTSGSKERASKSQDRKSASREK 599
D +K E K GS G + VM +E+ ++SQ+ K
Sbjct: 187 DKEKE--EEEEEKPKRGSIGENQVEVM---------------VEEKTTESQEETVVMSLK 229
Query: 600 RSVVSFDKVKEPRKSRDSESHSRVRERSEREQRMQAQWER-----EERERLEIARER-LA 653
+S ++ K+ + E+ E E + +A+ ER EERER++ +++ +A
Sbjct: 230 NGQISSEEPKQEEEREQGSDEISHHEKMEEEDKERAEAERARLEAEERERIKAEQDKKIA 289
Query: 654 FQRQRLE-------RERMERERLERERMHVEHERRREQERIHREREELRRQQELRYEQER 706
+R R+E +ER RE ERERM E +R E+ + +E E+ ++ R ++E
Sbjct: 290 DERARIEAEEKAAAQERERREAEERERMREEEKRAAEERQRIKEEEKRAAEERQRIKEEE 349
Query: 707 RPAVRRPYDLDRRDDAYWPEAKRAALDERYHSDFNRQDR 745
+ A + + E +RA +E + Q R
Sbjct: 350 KRAAEERQRIKEEEKRAAEERQRARAEEEEKAKVEEQKR 388
Score = 65.9 bits (159), Expect = 2e-10
Identities = 133/629 (21%), Positives = 238/629 (37%), Gaps = 70/629 (11%)
Query: 93 RKPEEEGVEDNGLEENSGDGQEDVETSLENLQDIDIMDISVLDEAEIDNGSVADCVEDDD 152
R+ +E + EE+ G + VE + +N SV DE E + VE DD
Sbjct: 43 RRARQERLRQKQEEESLGQVTDQVEVNAQN---------SVPDE-EAKTTTTNTQVEGDD 92
Query: 153 ADNLQESLSDSRELVEGEMKELPEQLQEHAIEDKETINNLDTSSSDFTILQEIEEPSLEP 212
E L+ E + ++E E+ +E TI + S + + E
Sbjct: 93 EAAFLERLARREERRQKRLQEALERQKEF----DPTITDASLSLPSRRMQNDTAENETTE 148
Query: 213 ENEKILDILGETCKSEPVKEESSELEQPFAQ-DTSSVGPDRKLAEEEDLFDSAHPEEGDL 271
+ EK E+ + EE+ + + + + D ++K +E++ + P+ G +
Sbjct: 149 KEEK-----SESRQERYEIEETETVTKSYQKNDWRDAEENKKEDKEKEEEEEEKPKRGSI 203
Query: 272 D------LASESTAHAQSSKADSLL--AVVKREPAEQPGDGERTDCEPVGLEPAVEQSSA 323
+ E T +Q L + E +Q + E+ E E E+
Sbjct: 204 GENQVEVMVEEKTTESQEETVVMSLKNGQISSEEPKQEEEREQGSDEISHHEKMEEEDK- 262
Query: 324 ASELAEASSEELAEAPTEAPSPEARDSKEDGRKFDFDACNEVPPAPKESSTSEGADQKMS 383
E AEA L E E +D K + +A + +E +E ++
Sbjct: 263 --ERAEAERARLEAEERERIKAE-QDKKIADERARIEAEEKAAAQERERREAEERERMRE 319
Query: 384 SPEDDSDTKRLSKEEKGRSSCGRNFWVSGLSSTTRATDLKNLFSKYGKVVGAKVVTNARS 443
+ ++ ++ KEE+ R++ R RA + + + K A+ AR+
Sbjct: 320 EEKRAAEERQRIKEEEKRAAEERQ---RIKEEEKRAAEERQRIKEEEKRA-AEERQRARA 375
Query: 444 PGARCYGFVTMSTAEEATKCINHLHKTELHGKMISVEKAKNEPVGKKTSDKRDSDGKKEK 503
EE K +L K ++++ K + G+K K + EK
Sbjct: 376 E------------EEEKAKVEEQKRNKQLEEKKHAMQETKIK--GEKVEQKIEGKWVNEK 421
Query: 504 SSNSDRSTNLKRDDKCDRKDDAKKGDDGSGEKSKDQDDQKPGPSER---SRATKSGSRGT 560
+ D K +K +KG ++ K Q+D+ E + K
Sbjct: 422 KAQED-----KLQTAVLKKQGEEKGTKVQAKREKLQEDKPTFKKEEIKDEKIKKDKEPKE 476
Query: 561 ERTVVMDKSKGVPVISVKTSGSKERASKSQDRKSASREKRSVVSFDKVKEPRKSRDSESH 620
E MD+ KG VK+ + K + ++ S D KE + E+
Sbjct: 477 EVKSFMDRKKGFT--EVKSQNGEFMTHKLKHTENTFSRPGGRASVD-TKEAEGAPQVEAG 533
Query: 621 SRVRERSEREQRMQAQWEREERERLEIARERLAFQRQRLERERMERERLERERMHVEHER 680
R+ E +R + + E EE E+L+ ++ A LE E ++++R ER ++ E E+
Sbjct: 534 KRLEEL----RRRRGETESEEFEKLKQKQQEAA-----LELEELKKKREERRKVLEEEEQ 584
Query: 681 RREQERIHREREELRRQQELRYEQERRPA 709
RR+QE R+ E ++ L+ E ERR A
Sbjct: 585 RRKQEEADRKLREEEEKRRLKEEIERRRA 613
Score = 65.1 bits (157), Expect = 3e-10
Identities = 61/262 (23%), Positives = 114/262 (43%), Gaps = 35/262 (13%)
Query: 490 KTSDKRDSDGKKEK---SSNSDRSTNLKRDDKCDRKDD-----AKKGDDGSGEKSKDQDD 541
K DK + ++EK S + + ++K + + K S E+ K +++
Sbjct: 184 KKEDKEKEEEEEEKPKRGSIGENQVEVMVEEKTTESQEETVVMSLKNGQISSEEPKQEEE 243
Query: 542 QKPGPSERSRATKSGSRGTERTVVMDKSKGVPVISVKTSGSKERASKSQDRKSASREKRS 601
++ G E S K DK + + + +ER QD+K A R
Sbjct: 244 REQGSDEISHHEKMEEE--------DKERAEAERARLEAEERERIKAEQDKKIADERARI 295
Query: 602 VVSFDKVKEPRKSRDSESHSRVRER----SEREQRMQAQWER--EERERLEIARERLAFQ 655
+ R+ R++E R+RE +E QR++ + +R EER+R++ +R A +
Sbjct: 296 EAEEKAAAQERERREAEERERMREEEKRAAEERQRIKEEEKRAAEERQRIKEEEKRAAEE 355
Query: 656 RQRLERERMERERLERERMHVEHERR---REQERIHREREELRRQQELRYEQERRPAVRR 712
RQR++ E +R ER+R E E + EQ+R + E+ QE + + E+
Sbjct: 356 RQRIKEEE-KRAAEERQRARAEEEEKAKVEEQKRNKQLEEKKHAMQETKIKGEK------ 408
Query: 713 PYDLDRRDDAYWPEAKRAALDE 734
++++ + W K+A D+
Sbjct: 409 ---VEQKIEGKWVNEKKAQEDK 427
Score = 40.4 bits (93), Expect = 0.008
Identities = 55/326 (16%), Positives = 121/326 (37%), Gaps = 32/326 (9%)
Query: 514 KRDDKCDRKDDAKKGDDGSGEKSKDQDDQKPGPSERSRATKSGSRGTERT---------V 564
+R+ + ++++ + + + D D+++ R RA + R + V
Sbjct: 7 RRELRRQKREEMRLEAERIAYQRNDDDEEEAARERRRRARQERLRQKQEEESLGQVTDQV 66
Query: 565 VMDKSKGVPVISVKTSGSKERASKSQD--------RKSASREKRSVVSFDKVKE------ 610
++ VP KT+ + + + R+ R+KR + ++ KE
Sbjct: 67 EVNAQNSVPDEEAKTTTTNTQVEGDDEAAFLERLARREERRQKRLQEALERQKEFDPTIT 126
Query: 611 ----PRKSRDSESHSRVRERSEREQRMQAQWEREERERLEIARERLAFQRQRLERERMER 666
SR ++ + E +E+E++ +++ ER E E E + Q+ + E
Sbjct: 127 DASLSLPSRRMQNDTAENETTEKEEKSESRQERYEIEETETVTK----SYQKNDWRDAEE 182
Query: 667 ERLERERMHVEHERRREQERIHREREELRRQQELRYEQERRPAVRRPYDLDRRDDAYWPE 726
+ E + E E + ++ I + E+ +++ QE + ++ E
Sbjct: 183 NKKEDKEKEEEEEEKPKRGSIGENQVEVMVEEKTTESQEETVVMSLKNGQISSEEPKQEE 242
Query: 727 AKRAALDE-RYHSDFNRQDRFHDFDHRDRGRYPDHSVDRREGSRSMMGEREGQHYPERHG 785
+ DE +H +D+ R R + + E + + ER E+
Sbjct: 243 EREQGSDEISHHEKMEEEDKERAEAERARLEAEERERIKAEQDKKIADERARIEAEEKAA 302
Query: 786 GPERHGRDSRDGWGGYGSDKRMSEGR 811
ER R++ + +KR +E R
Sbjct: 303 AQERERREAEERERMREEEKRAAEER 328
Score = 35.4 bits (80), Expect = 0.24
Identities = 20/51 (39%), Positives = 29/51 (56%), Gaps = 1/51 (1%)
Query: 655 QRQRLERERMERERLERERMHVEHERRREQERIHREREELRRQQELRYEQE 705
+R+ L R++ E RLE ER+ + E+E RER RQ+ LR +QE
Sbjct: 6 RRRELRRQKREEMRLEAERIAYQRNDDDEEEAA-RERRRRARQERLRQKQE 55
>gi|22035604 mitogen-activated protein kinase kinase kinase kinase 4
isoform 2 [Homo sapiens]
Length = 1320
Score = 72.0 bits (175), Expect = 2e-12
Identities = 74/300 (24%), Positives = 130/300 (43%), Gaps = 32/300 (10%)
Query: 538 DQDDQKPGPSERSRATKSGSRGTERTVVMDKSKGVPVISVKTSGSKER-----ASKSQDR 592
D+ +K G + + SGS E V + + +++V + R ++++R
Sbjct: 307 DRTRKKRGEKDETEYEYSGSEEEEEEVPEQEGEPSSIVNVPGESTLRRDFLRLQQENKER 366
Query: 593 KSASREKRSVVS--FDKVKEPRKSRDSESHSRVRERSEREQRMQAQWEREERERLEIARE 650
A R ++ + + +E ++ +E R+ ++ E+ +R++ Q RE R + RE
Sbjct: 367 SEALRRQQLLQEQQLREQEEYKRQLLAERQKRIEQQKEQRRRLEEQQRREREARRQQERE 426
Query: 651 RLAFQRQRLERERMERERLERERMHVEHERRREQE--RIHREREELRRQQELRYEQERRP 708
QR+R + E+ E LER R E RR E+E R+ RE+E +RRQ E E++R
Sbjct: 427 ----QRRREQEEKRRLEELERRRKEEEERRRAEEEKRRVEREQEYIRRQLE---EEQRHL 479
Query: 709 AVRRPYDLDRRD---DAYWPEAKRAALDERYHSDFNRQDRF-HDFDHRDRGRYPDHSVD- 763
V + L + + W E + ER ++ + H R +P HS
Sbjct: 480 EVLQQQLLQEQAMLLECRWREMEEHRQAERLQRQLQQEQAYLLSLQHDHRRPHPQHSQQP 539
Query: 764 ---RREGSRSMMGEREGQHYPERHGGPERHGRDSRDGW--GGYGSDKRMSE--GRGLPPP 816
++E S+ E P+ H P R+ D + + S + S+ GR L PP
Sbjct: 540 PPPQQERSKPSFHAPE----PKAHYEPADRAREVEDRFRKTNHSSPEAQSKQTGRVLEPP 595
>gi|22035606 mitogen-activated protein kinase kinase kinase kinase 4
isoform 3 [Homo sapiens]
Length = 1212
Score = 71.6 bits (174), Expect = 3e-12
Identities = 86/317 (27%), Positives = 133/317 (41%), Gaps = 43/317 (13%)
Query: 624 RERSEREQRMQAQWEREERERLEIARERLAFQRQRLERERMERERLERERMHVEHERRRE 683
+ERSE +R Q E++ RE+ E R+ LA +++R+E+++ +R RLE E+ E E RR+
Sbjct: 364 KERSEALRRQQLLQEQQLREQEEYKRQLLAERQKRIEQQKEQRRRLE-EQQRREREARRQ 422
Query: 684 QERIHR--EREELRRQQELRYEQERRPAVRRPYDLDRRDDAYWPEAKRAALDERYHSDFN 741
QER R E+EE RR +EL ++ RR + RR + +R +E+ H +
Sbjct: 423 QEREQRRREQEEKRRLEELERRRKEEEERRRAEEEKRRVEREQEYIRRQLEEEQRHLEVL 482
Query: 742 RQDRFHD---FDHRDRGRYPDHSVD----RREGSRSMMGEREGQHYPERHGGPERHGRDS 794
+Q + H R +P HS ++E S+ E P+ H P R+
Sbjct: 483 QQQLLQEQAMLLHDHRRPHPQHSQQPPPPQQERSKPSFHAPE----PKAHYEPADRAREV 538
Query: 795 RDGWG--GYGSDKRMSE--GRGLPPP--PRRDWGDHGRREDDR-SWQGTADGGMMDRDHK 847
D + + S + S+ GR L PP R + +G E + Q A+ + R
Sbjct: 539 EDRFRKTNHSSPEAQSKQTGRVLEPPVPSRSESFSNGNSESVHPALQRPAEPQVPVRTTS 598
Query: 848 RWQGGERSMSGHSGPGHMMNRGGMS----------------------GRGSFAPGGASRG 885
R R S G G ++ G G GS + S
Sbjct: 599 RSPVLSRRDSPLQGSGQQNSQAGQRNSTSSIEPRLLWERVEKLVPRPGSGSSSGSSNSGS 658
Query: 886 HPIPHGGMQGGFGGQSR 902
P H G Q G G + R
Sbjct: 659 QPGSHPGSQSGSGERFR 675
Score = 58.5 bits (140), Expect = 3e-08
Identities = 50/213 (23%), Positives = 96/213 (45%), Gaps = 17/213 (7%)
Query: 507 SDRSTNLKRDDKCDR-------KDDAKKGDDGSGEKSKDQDDQKPGPSERSRATKSGSRG 559
++R ++ D DR KD+ + GS E+ ++ +Q+ PS +
Sbjct: 294 NERQVRIQLKDHIDRTRKKRGEKDETEYEYSGSEEEEEEVPEQEGEPSSIVNVPGESTLR 353
Query: 560 TERTVVMDKSKGVPVISVKTSGSKERASKSQDRKS----ASREKRSVVSFDKVKEPRKSR 615
+ + ++K + +E+ + Q+ A R+KR ++ KE R+ R
Sbjct: 354 RDFLRLQQENKERSEALRRQQLLQEQQLREQEEYKRQLLAERQKR----IEQQKEQRR-R 408
Query: 616 DSESHSRVRERSEREQRMQAQWEREERERLEIARERLAFQRQRLERERMERERLERERMH 675
E R RE +++R Q + E+EE+ RLE R + +R E E+ R+ERE+ +
Sbjct: 409 LEEQQRREREARRQQEREQRRREQEEKRRLEELERRRKEEEERRRAEE-EKRRVEREQEY 467
Query: 676 VEHERRREQERIHREREELRRQQELRYEQERRP 708
+ + EQ + +++L ++Q + RRP
Sbjct: 468 IRRQLEEEQRHLEVLQQQLLQEQAMLLHDHRRP 500
Score = 35.0 bits (79), Expect = 0.32
Identities = 51/205 (24%), Positives = 85/205 (41%), Gaps = 47/205 (22%)
Query: 583 KERASKSQDRKSASREKRSVVSFDKVKEPRKSRDSESHSRVRERSEREQRMQAQWEREER 642
+ A + Q+R+ RE+ +E R+ + E R R E E+R +A+ EE+
Sbjct: 416 EREARRQQEREQRRREQ---------EEKRRLEELE-----RRRKEEEERRRAE---EEK 458
Query: 643 ERLEIARERLAFQRQRLERERMERERLERERMHVEHERRREQERIHREREELRRQQELRY 702
R+E +E + R++LE E+ E L+++ + + + R H + QQ
Sbjct: 459 RRVEREQE---YIRRQLEEEQRHLEVLQQQLLQEQAMLLHDHRRPHPQHS----QQPPPP 511
Query: 703 EQER-RPAVRRPYDLDRRDDAYWPEAKRAALDERYHSDFNRQDRFHDFDH-------RDR 754
+QER +P+ P A++ A RA +DRF +H +
Sbjct: 512 QQERSKPSFHAP-----EPKAHYEPADRAR---------EVEDRFRKTNHSSPEAQSKQT 557
Query: 755 GRYPDHSVDRREGSRSMMGEREGQH 779
GR + V R S S G E H
Sbjct: 558 GRVLEPPVPSRSESFS-NGNSESVH 581
>gi|21040326 SON DNA-binding protein isoform F [Homo sapiens]
Length = 2426
Score = 70.9 bits (172), Expect = 5e-12
Identities = 131/591 (22%), Positives = 209/591 (35%), Gaps = 74/591 (12%)
Query: 166 LVEGEMKELPEQLQEHAIEDKETINNLDTSSSDFTILQEIEE------------------ 207
L GE E L+ E + IN +D + ++ I +E+E
Sbjct: 1507 LHSGEEPHAEEHLKGDFYESEHGIN-IDLNINNHLIAKEMEHNTVCAAGTSPVGEIGEEK 1565
Query: 208 --PSLEPENEKILDILGETCKSEPVKEESSELEQPFAQDTSSVGPDRKLA-EEEDLFDSA 264
P+ E + +LD +++ + SS PFA + + G + +
Sbjct: 1566 ILPTSETKQRTVLDTYPGVSEADAGETLSST--GPFALEPDATGTSKGIEFTTASTLSLV 1623
Query: 265 HPEEGDLDLASESTAHAQSSKADSLLAVVKREPAEQPGDGERTDCEPVGLEPAVEQSSAA 324
+ + DL L ++ T H D +++ P G D E G PA +
Sbjct: 1624 NKYDVDLSLTTQDTEH------DMVIST-------SPSGGSEADIE--GPLPAKD----- 1663
Query: 325 SELAEASSEELAEAPTEAPSPEARDSKED-----GRKFDFDACNEVPPAPKESSTSEGAD 379
L S+ L TE P P ++S + K EVPP PKE+ G
Sbjct: 1664 IHLDLPSNNNLVSKDTEEPLP-VKESDQTLAALLSPKESSGGEKEVPPPPKETLPDSGFS 1722
Query: 380 QKMSSPEDDSDTKRLSKEEKGRSSCGRNFWVSGLSSTTRATDLKNLFSKYGKVVGAKVVT 439
+ + + L ++ R + R +G+ A+D+ S VV +
Sbjct: 1723 ANIEDINEADLVRPLLPKDMERLTSLR----AGIEGPLLASDVGRDRSAASPVVSSMPER 1778
Query: 440 NARSPGARCYG---FVTMSTAEEATKCINHLHKTELHGKMISV-------EKAKNEPVGK 489
+ S FV + E +K + K E K S K+ K
Sbjct: 1779 ASESSSEEKDDYEIFVKVKDTHEKSKKNKNRDKGEKEKKRDSSLRSRSKRSKSSEHKSRK 1838
Query: 490 KTSDKRDSDGKKEKSSNSDRSTNLKRDDKCDRKDDAKKGDDGSGEKSKDQDDQKPGPSER 549
+TS+ R K+ S S RS R R+ ++ G +S ++ +K P R
Sbjct: 1839 RTSESRSRARKRSSKSKSHRSQTRSRSRSRRRRRSSRSRSKSRGRRSVSKEKRKRSPKHR 1898
Query: 550 S----RATKSGSRGTERTVVMDKSKGVPVISVKTSGSKERASKSQDRK---SASREKRSV 602
S R K S R V +S+ S + S+ R S+S R+ S S +RS
Sbjct: 1899 SKSRERKRKRSSSRDNRKTVRARSRTPSRRSRSHTPSRRRRSRSVGRRRSFSISPSRRSR 1958
Query: 603 VSFDKVKEP-RKSRDSESHSRV-RERSEREQRMQAQWEREERERLEIARERLAFQRQRLE 660
+ + P R+SR SR RS R R R R + R + RL
Sbjct: 1959 TPSRRSRTPSRRSRTPSRRSRTPSRRSRTPSRRSRTPSRRRRSRSVVRRRSFSISPVRLR 2018
Query: 661 RERME-RERLERERMHVEHERRREQERIHREREELRRQQELRYEQERRPAV 710
R R R R R + + R E+ R + +L + Q L + A+
Sbjct: 2019 RSRTPLRRRFSRSPIRRKRSRSSERGRSPKRLTDLDKAQLLEIAKANAAAM 2069
Score = 52.0 bits (123), Expect = 3e-06
Identities = 85/353 (24%), Positives = 138/353 (39%), Gaps = 59/353 (16%)
Query: 479 VEKAKNEPVGKKTSD---------KRDSDGKKEKSS-------NSDRSTNLKRDDKCD-- 520
V K EP+ K SD K S G+KE +S S N++ ++ D
Sbjct: 1675 VSKDTEEPLPVKESDQTLAALLSPKESSGGEKEVPPPPKETLPDSGFSANIEDINEADLV 1734
Query: 521 ---------RKDDAKKGDDG---SGEKSKDQDDQKPGPSER-SRATKSGSRGTERTVVMD 567
R + G +G + + +D+ P S RA++S S
Sbjct: 1735 RPLLPKDMERLTSLRAGIEGPLLASDVGRDRSAASPVVSSMPERASESSS---------- 1784
Query: 568 KSKGVPVISVKTSGSKERASKSQDRKSASREKRSVVSFDKVKEPRKS-------RDSESH 620
+ K I VK + E++ K+++R +EK+ S + KS R SES
Sbjct: 1785 EEKDDYEIFVKVKDTHEKSKKNKNRDKGEKEKKRDSSLRSRSKRSKSSEHKSRKRTSESR 1844
Query: 621 SRVRERSEREQ--RMQAQWEREERERLEIARERLAFQ-RQRLERERMERERLERERMHVE 677
SR R+RS + + R Q + R R +R R + R+ + +E+ +R R + E
Sbjct: 1845 SRARKRSSKSKSHRSQTRSRSRSRRRRRSSRSRSKSRGRRSVSKEKRKRSPKHRSKSR-E 1903
Query: 678 HERRREQERIHREREELRRQQELRYEQERRPA-VRRPYDLDRRDDAYWPEAKRAALDERY 736
+R+R R +R+ R + R + P+ RR + RR ++R+ R
Sbjct: 1904 RKRKRSSSRDNRKTVRARSRTPSRRSRSHTPSRRRRSRSVGRRRSFSISPSRRSRTPSRR 1963
Query: 737 HSDFNRQDRFHDFDHRD---RGRYP---DHSVDRREGSRSMMGEREGQHYPER 783
+R+ R R R R P + RR SRS++ R P R
Sbjct: 1964 SRTPSRRSRTPSRRSRTPSRRSRTPSRRSRTPSRRRRSRSVVRRRSFSISPVR 2016
>gi|21040314 SON DNA-binding protein isoform B [Homo sapiens]
Length = 2303
Score = 70.9 bits (172), Expect = 5e-12
Identities = 131/591 (22%), Positives = 209/591 (35%), Gaps = 74/591 (12%)
Query: 166 LVEGEMKELPEQLQEHAIEDKETINNLDTSSSDFTILQEIEE------------------ 207
L GE E L+ E + IN +D + ++ I +E+E
Sbjct: 1507 LHSGEEPHAEEHLKGDFYESEHGIN-IDLNINNHLIAKEMEHNTVCAAGTSPVGEIGEEK 1565
Query: 208 --PSLEPENEKILDILGETCKSEPVKEESSELEQPFAQDTSSVGPDRKLA-EEEDLFDSA 264
P+ E + +LD +++ + SS PFA + + G + +
Sbjct: 1566 ILPTSETKQRTVLDTYPGVSEADAGETLSST--GPFALEPDATGTSKGIEFTTASTLSLV 1623
Query: 265 HPEEGDLDLASESTAHAQSSKADSLLAVVKREPAEQPGDGERTDCEPVGLEPAVEQSSAA 324
+ + DL L ++ T H D +++ P G D E G PA +
Sbjct: 1624 NKYDVDLSLTTQDTEH------DMVIST-------SPSGGSEADIE--GPLPAKD----- 1663
Query: 325 SELAEASSEELAEAPTEAPSPEARDSKED-----GRKFDFDACNEVPPAPKESSTSEGAD 379
L S+ L TE P P ++S + K EVPP PKE+ G
Sbjct: 1664 IHLDLPSNNNLVSKDTEEPLP-VKESDQTLAALLSPKESSGGEKEVPPPPKETLPDSGFS 1722
Query: 380 QKMSSPEDDSDTKRLSKEEKGRSSCGRNFWVSGLSSTTRATDLKNLFSKYGKVVGAKVVT 439
+ + + L ++ R + R +G+ A+D+ S VV +
Sbjct: 1723 ANIEDINEADLVRPLLPKDMERLTSLR----AGIEGPLLASDVGRDRSAASPVVSSMPER 1778
Query: 440 NARSPGARCYG---FVTMSTAEEATKCINHLHKTELHGKMISV-------EKAKNEPVGK 489
+ S FV + E +K + K E K S K+ K
Sbjct: 1779 ASESSSEEKDDYEIFVKVKDTHEKSKKNKNRDKGEKEKKRDSSLRSRSKRSKSSEHKSRK 1838
Query: 490 KTSDKRDSDGKKEKSSNSDRSTNLKRDDKCDRKDDAKKGDDGSGEKSKDQDDQKPGPSER 549
+TS+ R K+ S S RS R R+ ++ G +S ++ +K P R
Sbjct: 1839 RTSESRSRARKRSSKSKSHRSQTRSRSRSRRRRRSSRSRSKSRGRRSVSKEKRKRSPKHR 1898
Query: 550 S----RATKSGSRGTERTVVMDKSKGVPVISVKTSGSKERASKSQDRK---SASREKRSV 602
S R K S R V +S+ S + S+ R S+S R+ S S +RS
Sbjct: 1899 SKSRERKRKRSSSRDNRKTVRARSRTPSRRSRSHTPSRRRRSRSVGRRRSFSISPSRRSR 1958
Query: 603 VSFDKVKEP-RKSRDSESHSRV-RERSEREQRMQAQWEREERERLEIARERLAFQRQRLE 660
+ + P R+SR SR RS R R R R + R + RL
Sbjct: 1959 TPSRRSRTPSRRSRTPSRRSRTPSRRSRTPSRRSRTPSRRRRSRSVVRRRSFSISPVRLR 2018
Query: 661 RERME-RERLERERMHVEHERRREQERIHREREELRRQQELRYEQERRPAV 710
R R R R R + + R E+ R + +L + Q L + A+
Sbjct: 2019 RSRTPLRRRFSRSPIRRKRSRSSERGRSPKRLTDLDKAQLLEIAKANAAAM 2069
Score = 52.0 bits (123), Expect = 3e-06
Identities = 85/353 (24%), Positives = 138/353 (39%), Gaps = 59/353 (16%)
Query: 479 VEKAKNEPVGKKTSD---------KRDSDGKKEKSS-------NSDRSTNLKRDDKCD-- 520
V K EP+ K SD K S G+KE +S S N++ ++ D
Sbjct: 1675 VSKDTEEPLPVKESDQTLAALLSPKESSGGEKEVPPPPKETLPDSGFSANIEDINEADLV 1734
Query: 521 ---------RKDDAKKGDDG---SGEKSKDQDDQKPGPSER-SRATKSGSRGTERTVVMD 567
R + G +G + + +D+ P S RA++S S
Sbjct: 1735 RPLLPKDMERLTSLRAGIEGPLLASDVGRDRSAASPVVSSMPERASESSS---------- 1784
Query: 568 KSKGVPVISVKTSGSKERASKSQDRKSASREKRSVVSFDKVKEPRKS-------RDSESH 620
+ K I VK + E++ K+++R +EK+ S + KS R SES
Sbjct: 1785 EEKDDYEIFVKVKDTHEKSKKNKNRDKGEKEKKRDSSLRSRSKRSKSSEHKSRKRTSESR 1844
Query: 621 SRVRERSEREQ--RMQAQWEREERERLEIARERLAFQ-RQRLERERMERERLERERMHVE 677
SR R+RS + + R Q + R R +R R + R+ + +E+ +R R + E
Sbjct: 1845 SRARKRSSKSKSHRSQTRSRSRSRRRRRSSRSRSKSRGRRSVSKEKRKRSPKHRSKSR-E 1903
Query: 678 HERRREQERIHREREELRRQQELRYEQERRPA-VRRPYDLDRRDDAYWPEAKRAALDERY 736
+R+R R +R+ R + R + P+ RR + RR ++R+ R
Sbjct: 1904 RKRKRSSSRDNRKTVRARSRTPSRRSRSHTPSRRRRSRSVGRRRSFSISPSRRSRTPSRR 1963
Query: 737 HSDFNRQDRFHDFDHRD---RGRYP---DHSVDRREGSRSMMGEREGQHYPER 783
+R+ R R R R P + RR SRS++ R P R
Sbjct: 1964 SRTPSRRSRTPSRRSRTPSRRSRTPSRRSRTPSRRRRSRSVVRRRSFSISPVR 2016
>gi|16332372 cell division cycle 2-like 1 (PITSLRE proteins) isoform
9 [Homo sapiens]
Length = 771
Score = 70.5 bits (171), Expect = 7e-12
Identities = 63/241 (26%), Positives = 106/241 (43%), Gaps = 18/241 (7%)
Query: 502 EKSSNSDRSTNLKRDDKCDRKDDAKKGDDGSGEKSKDQDDQKPGPSERS------RATKS 555
EK S ++ + +K RK+ +K + + S D+D ++ E T
Sbjct: 4 EKDSWKVKTLDEILQEKKRRKEQEEKAEIKRLKNSDDRDSKRDSLEEGELRDHCMEITIR 63
Query: 556 GSRGTERTVVMDKSKGVPVISVKTSGSKERASKSQDRKSASREKRSVVSFDKVKEPRKSR 615
S + D+ + +++K R K RK EKR +VKE K R
Sbjct: 64 NSPYRREDSMEDRGEEDDSLAIKPPQQMSRKEKVHHRKD---EKRKEKKHARVKE--KER 118
Query: 616 DSESHSRVRERSEREQRMQAQWEREERERLEIARERLAFQRQRLERERMERERLERERMH 675
+ E R RE ++ +R +WER++R E+ARE +R RLE+ +ER+R +M
Sbjct: 119 EHERRKRHREEQDKARR---EWERQKRR--EMAREHSRRERDRLEQ--LERKRERERKMR 171
Query: 676 VEHERRREQERIHREREELRRQQELRYEQERRPAVRRPYDLDRRDDAYWPEAKRAALDER 735
+ + +REQ+ R EE R+++E R E R D+ ++W + ER
Sbjct: 172 EQQKEQREQKERERRAEERRKEREARREVSAHHRTMREDYSDKVKASHWSRSPPRPPRER 231
Query: 736 Y 736
+
Sbjct: 232 F 232
Score = 46.6 bits (109), Expect = 1e-04
Identities = 69/328 (21%), Positives = 137/328 (41%), Gaps = 33/328 (10%)
Query: 88 RSSKGRKPEEEGVEDNGLEENSGDGQEDVETSLENLQDID-IMDISVLDEAEIDNGSVAD 146
+ K RK +EE E L+ + D ++ SLE + D M+I++ + S+ D
Sbjct: 18 QEKKRRKEQEEKAEIKRLKNS--DDRDSKRDSLEEGELRDHCMEITIRNSPYRREDSMED 75
Query: 147 CVEDDDADNLQESLSDSRELVEGEMKELPEQLQEHA-IEDKETINNLDTSSSDFTILQEI 205
E+DD+ ++ SR+ K+ + ++HA +++KE + +E
Sbjct: 76 RGEEDDSLAIKPPQQMSRKEKVHHRKDEKRKEKKHARVKEKEREHERRKRHR-----EEQ 130
Query: 206 EEPSLEPENEKILDILGETCKSEPVKEESSELEQPFAQDTSSVGPDRKLAEEEDLFDSAH 265
++ E E +K ++ E + E ++ +LE+ ++ ++ E+++ A
Sbjct: 131 DKARREWERQKRREMAREHSRRE--RDRLEQLERKRERERKMREQQKEQREQKERERRAE 188
Query: 266 PEEGDLDLASESTAHAQSSKADSLLAVV----KREPAEQP------GDGERTDCEPVGLE 315
+ + E +AH ++ + D V R P P GDG + PV E
Sbjct: 189 ERRKEREARREVSAHHRTMREDYSDKVKASHWSRSPPRPPRERFELGDGRK----PV-KE 243
Query: 316 PAVEQSSAASELAEASSEELAEAPTEAPSPEARDSKEDGRKFDFDACNEVPPAPKESSTS 375
+E+ S+L + S E + E+ S E+ E+ + E +E STS
Sbjct: 244 EKMEERDLLSDLQDISDSERKTSSAESSSAESGSGSEEEEE-------EEEEEEEEGSTS 296
Query: 376 EGADQKMSSPEDDSDTKRLSKEEKGRSS 403
E ++++ E++ + + EE S
Sbjct: 297 EESEEEEEEEEEEEEETGSNSEEASEQS 324
Score = 42.0 bits (97), Expect = 0.003
Identities = 35/172 (20%), Positives = 71/172 (41%), Gaps = 11/172 (6%)
Query: 609 KEPRKSRDSESHSRVRERSEREQRMQAQWEREERERLEIARERLAFQRQRLERERMERER 668
++ + R E S + ++ R + R++ +R E R+ + + ER + RE
Sbjct: 70 EDSMEDRGEEDDSLAIKPPQQMSRKEKVHHRKDEKRKEKKHARVKEKEREHERRKRHREE 129
Query: 669 LERERMHVEHERRREQERIHREREELRRQQELRYEQERRPAVRRPYDLDRRDDAYWPEAK 728
++ R E ++RRE R H RR+++ + ER+ R +++ E +
Sbjct: 130 QDKARREWERQKRREMAREHS-----RRERDRLEQLERKRERERKMREQQKEQREQKERE 184
Query: 729 RAALDERYHSDFNRQDRFH------DFDHRDRGRYPDHSVDRREGSRSMMGE 774
R A + R + R+ H D+ + + + S R R +G+
Sbjct: 185 RRAEERRKEREARREVSAHHRTMREDYSDKVKASHWSRSPPRPPRERFELGD 236
Score = 40.8 bits (94), Expect = 0.006
Identities = 61/303 (20%), Positives = 115/303 (37%), Gaps = 29/303 (9%)
Query: 489 KKTSDKRDSDGKKEKSSNSDRSTNLKRDDKCDRKDDAKKGDDGSGEKSKDQDDQKPGPSE 548
+K +K+ + K+++ + R + + DK R+ + +K + + E S+ + D+ E
Sbjct: 103 EKRKEKKHARVKEKEREHERRKRHREEQDKARREWERQKRREMAREHSRRERDRLE-QLE 161
Query: 549 RSRATKSGSRGTERTVVMDKSKGVPVISVKTSGSKERASKSQDRKSASREKRSVVS--FD 606
R R + R ++ K + ++ER + + R+ S R++ D
Sbjct: 162 RKRERERKMREQQKEQREQKER--------ERRAEERRKEREARREVSAHHRTMREDYSD 213
Query: 607 KVKEPRKSRDSESHSRVRERSEREQRMQAQWEREERERLEIARERLAFQRQRLERERMER 666
KVK SR R R ++ + + EER+ L ++ +R+ E
Sbjct: 214 KVKASHWSRSPPRPPRERFELGDGRKPVKEEKMEERDLLSDLQDISDSERKTSSAESSSA 273
Query: 667 ERLERERMHVEHERRREQERIHREREELRRQQELRYEQERRPAVRRPYDLDRRDDAYWPE 726
E E E E+E E E ++E E+E ++A
Sbjct: 274 ESGSGSEEEEEEEEEEEEEGSTSEESEEEEEEEEEEEEETG---------SNSEEASEQS 324
Query: 727 AKRAALDERYHSDFNRQDRFH-------DFDHRDRGRYPDHSVDRREGSRSMMGEREGQH 779
A+ + +E D R++ H FD RD G + + EG+ EG +
Sbjct: 325 AEEVS-EEEMSEDEERENENHLLVVPESRFD-RDSGESEEAEEEVGEGTPQSSALTEGDY 382
Query: 780 YPE 782
P+
Sbjct: 383 VPD 385
Score = 32.7 bits (73), Expect = 1.6
Identities = 37/148 (25%), Positives = 63/148 (42%), Gaps = 14/148 (9%)
Query: 160 LSDSRELVEGEMKE---LPEQLQEHAIEDKETINNLDTSSSDFTILQEIEEPSLEPENEK 216
L D R+ V+ E E L LQ+ + +++T + +S+ + +E EE E E E+
Sbjct: 234 LGDGRKPVKEEKMEERDLLSDLQDISDSERKTSSAESSSAESGSGSEEEEE---EEEEEE 290
Query: 217 ILDILGETCKSEPVKEESSELEQPFAQDTSSVGPDRKLAEEEDLFDSAHPEEGDLDLASE 276
E + E +EE E E + +S +++EEE D E L + E
Sbjct: 291 EEGSTSEESEEEEEEEEEEEEETGSNSEEASEQSAEEVSEEEMSEDEERENENHLLVVPE 350
Query: 277 STAHAQSSKADSLLAVVKREPAEQPGDG 304
S S +++ E E+ G+G
Sbjct: 351 SRFDRDSGESE--------EAEEEVGEG 370
>gi|16332358 cell division cycle 2-like 1 (PITSLRE proteins) isoform
2 [Homo sapiens]
Length = 782
Score = 70.5 bits (171), Expect = 7e-12
Identities = 57/244 (23%), Positives = 104/244 (42%), Gaps = 13/244 (5%)
Query: 502 EKSSNSDRSTNLKRDDKCDRKDDAKKGDDGSGEKSKDQDDQKPGPSE------RSRATKS 555
EK S ++ + +K RK+ +K + + S D+D ++ E R T
Sbjct: 4 EKDSWKVKTLDEILQEKKRRKEQEEKAEIKRLKNSDDRDSKRDSLEEGELRDHRMEITIR 63
Query: 556 GSRGTERTVVMDKSKGVPVISVKTS---GSKERASKSQDRKSASREKRSVVSFDKVKEPR 612
S + D+ + +++K KE+ +D K + + S + K R
Sbjct: 64 NSPYRREDSMEDRGEEDDSLAIKPPQQMSRKEKVHHRKDEKRKEKRRHRSHSAEGGKHAR 123
Query: 613 KSRDSESHSRVRERSEREQRMQAQWEREERERLEIARERLAFQRQRLERERMERERLERE 672
H R + E + + + +WER++R E+ARE +R RL E++ER+R
Sbjct: 124 VKEKEREHERRKRHREEQDKARREWERQKRR--EMAREHSRRERDRL--EQLERKRERER 179
Query: 673 RMHVEHERRREQERIHREREELRRQQELRYEQERRPAVRRPYDLDRRDDAYWPEAKRAAL 732
+M + + +REQ+ R EE R+++E R E R D+ ++W +
Sbjct: 180 KMREQQKEQREQKERERRAEERRKEREARREVSAHHRTMREDYSDKVKASHWSRSPPRPP 239
Query: 733 DERY 736
ER+
Sbjct: 240 RERF 243
Score = 40.0 bits (92), Expect = 0.010
Identities = 57/319 (17%), Positives = 119/319 (37%), Gaps = 28/319 (8%)
Query: 480 EKAKNEPVGKKTSDKRDSDGKKEKSSNSDRSTNLKRDDKCDRKDDAKKGDDGSGEKSKDQ 539
+ ++ E V + +KR + ++ +S +++ + + +K + K+ + + ++
Sbjct: 90 QMSRKEKVHHRKDEKR-KEKRRHRSHSAEGGKHARVKEKEREHERRKRHREEQDKARREW 148
Query: 540 DDQKPGPSERSRATKSGSRGTERTVVMDKSKGVPVISVKTSGSKERASKSQDRKSASREK 599
+ QK R + + R + ++ + + + KER ++++R+ +
Sbjct: 149 ERQKRREMAREHSRRERDRLEQLERKRERERKMREQQKEQREQKERERRAEERRKEREAR 208
Query: 600 RSVVSF---------DKVKEPRKSRDSESHSRVRERSEREQRMQAQWEREERERLEIARE 650
R V + DKVK SR R R ++ + + EER+ L ++
Sbjct: 209 REVSAHHRTMREDYSDKVKASHWSRSPPRPPRERFELGDGRKPVKEEKMEERDLLSDLQD 268
Query: 651 RLAFQRQRLERERMERERLERERMHVEHERRREQERIHREREELRRQQELRYEQERRPAV 710
+R+ E E E E E+E E E ++E E+E
Sbjct: 269 ISDSERKTSSAESSSAESGSGSEEEEEEEEEEEEEGSTSEESEEEEEEEEEEEEETG--- 325
Query: 711 RRPYDLDRRDDAYWPEAKRAALDERYHSDFNRQDRFH-------DFDHRDRGRYPDHSVD 763
++A A+ + +E D R++ H FD RD G + +
Sbjct: 326 ------SNSEEASEQSAEEVS-EEEMSEDEERENENHLLVVPESRFD-RDSGESEEAEEE 377
Query: 764 RREGSRSMMGEREGQHYPE 782
EG+ EG + P+
Sbjct: 378 VGEGTPQSSALTEGDYVPD 396
Score = 32.7 bits (73), Expect = 1.6
Identities = 37/148 (25%), Positives = 63/148 (42%), Gaps = 14/148 (9%)
Query: 160 LSDSRELVEGEMKE---LPEQLQEHAIEDKETINNLDTSSSDFTILQEIEEPSLEPENEK 216
L D R+ V+ E E L LQ+ + +++T + +S+ + +E EE E E E+
Sbjct: 245 LGDGRKPVKEEKMEERDLLSDLQDISDSERKTSSAESSSAESGSGSEEEEE---EEEEEE 301
Query: 217 ILDILGETCKSEPVKEESSELEQPFAQDTSSVGPDRKLAEEEDLFDSAHPEEGDLDLASE 276
E + E +EE E E + +S +++EEE D E L + E
Sbjct: 302 EEGSTSEESEEEEEEEEEEEEETGSNSEEASEQSAEEVSEEEMSEDEERENENHLLVVPE 361
Query: 277 STAHAQSSKADSLLAVVKREPAEQPGDG 304
S S +++ E E+ G+G
Sbjct: 362 SRFDRDSGESE--------EAEEEVGEG 381
>gi|239757964 PREDICTED: hypothetical protein [Homo sapiens]
Length = 290
Score = 68.9 bits (167), Expect = 2e-11
Identities = 52/248 (20%), Positives = 116/248 (46%), Gaps = 22/248 (8%)
Query: 474 GKMISVEKAKNEPVGKKTSDKRDSDGKKEKSSNSDRSTNLKRDDKCDRKDDAKKGDDGSG 533
G++ S E ++ +G+ D D ++E+ +++ K D+ ++D ++ +
Sbjct: 52 GRLGSQESPRSWGLGQAHKDADGDDRQRERDRVREKTE--KERDRDRKRDRERRRKEKET 109
Query: 534 EKSKDQDDQKPGPSERSRATKSG-----SRGTERTVVMDKSKGVPVISVKTSGSKERASK 588
+++D++ Q +R R + G RG ER D+ K ER +
Sbjct: 110 NRNRDREKQTEIERDREREKQKGRERERDRGRERERDRDREK-------------ERERQ 156
Query: 589 SQDRKSASREKRSVVSFDKVKEPRKSRDSESHSRVRERSEREQRMQAQWEREERERLEIA 648
++ + RE + D+ +E +K R++E + +E+E+ Q ER+ + + +
Sbjct: 157 TEKDRDGQRETETERERDREREKQKERETERDRDRQRDTEKERERQTDRERDRQRKTQTE 216
Query: 649 RERLAFQRQRLERERMERERLERER-MHVEHER-RREQERIHREREELRRQQELRYEQER 706
R+R + E +R + +R+R + ER R+E+ + R++E + ++E + E++R
Sbjct: 217 RQRETDREGERETDRRRERQRDRDRGKERDRERDRKEERKKERKKERKKERKEKKKEEKR 276
Query: 707 RPAVRRPY 714
R +R +
Sbjct: 277 REDKKRKW 284
Score = 65.9 bits (159), Expect = 2e-10
Identities = 73/269 (27%), Positives = 112/269 (41%), Gaps = 45/269 (16%)
Query: 556 GSRGTERTVVMDKSKGVPVISVKTSGSKE--------RASKSQDRKSASREKRSVVSFDK 607
G+ E T+ +D S+G GS+E +A K D RE+ D+
Sbjct: 37 GTLWVEVTIPLDFSRG-------RLGSQESPRSWGLGQAHKDADGDDRQRER------DR 83
Query: 608 VKEPRKSRDSESHSRVRERSEREQRMQAQWEREERERLEIARERLAFQRQRLERER-MER 666
V+E + R RER +E+ +RE++ +E RER + + ER+R ER
Sbjct: 84 VREKTEKERDRDRKRDRERRRKEKETNRNRDREKQTEIERDREREKQKGRERERDRGRER 143
Query: 667 ER-----LERERM---------HVEHERRREQERIHREREELRRQQELR--YEQERRPAV 710
ER ERER E ER R++ER ++ E R ++ + E+ER
Sbjct: 144 ERDRDREKERERQTEKDRDGQRETETERERDREREKQKERETERDRDRQRDTEKERERQT 203
Query: 711 RRPYDLDRRDDAYWPEAKRAALDERYHSDFNRQDRFHDFDHRDRGRYPDHSVDRREGSRS 770
R D R+ E +R E R++R D RDRG+ D DR+E R
Sbjct: 204 DRERDRQRKTQT---ERQRETDREGERETDRRRERQRD---RDRGKERDRERDRKE-ERK 256
Query: 771 MMGEREGQHYPERHGGPERHGRDSRDGWG 799
++E + + E+ D + WG
Sbjct: 257 KERKKERKKERKEKKKEEKRREDKKRKWG 285
>gi|217330641 IWS1 homolog [Homo sapiens]
Length = 819
Score = 68.9 bits (167), Expect = 2e-11
Identities = 133/584 (22%), Positives = 233/584 (39%), Gaps = 96/584 (16%)
Query: 140 DNGSVADCVEDDDADNLQESLSDSRELVEGEMKELPEQLQEHAIEDKETINNLDTSSSDF 199
D GSV E++ +D ++ L + + E E P L E +E D+ S
Sbjct: 41 DTGSVERHSENETSDR-EDGLPKGHHVTDSENDE-PLNLNASDSESEELHRQKDSDSESE 98
Query: 200 TILQEIEEPSLEPENEKILDILGETCKSEPVKEESSELEQPFAQDTSSVGPDRKLAEEED 259
+ E P+ + ENE + S+ EE+ +L +++ + +E ED
Sbjct: 99 ---ERAEPPASDSENEDV-----NQHGSDSESEETRKLPGSDSENEELLNGHASDSENED 150
Query: 260 LFDSAHP-EEGDLDLASESTAHAQSSKADSLLAVVKREPAEQPGDGERTDCEPVGLEPAV 318
+ HP + +++ +S A + S D+L + +E+P + +D E
Sbjct: 151 V--GKHPASDSEIEELQKSPA-SDSETEDALKPQISDSESEEPPRHQASDSE-------- 199
Query: 319 EQSSAASELAEASSEELAEAPTEAPSPEARDSK--EDGRKFDFDACNEVPPAPKES-STS 375
+ ++++ SEEL P P+ DS+ E R D+ NE P P+ S S S
Sbjct: 200 NEEPPKPRMSDSESEEL-------PKPQVSDSESEEPPRHQASDSENEELPKPRISDSES 252
Query: 376 EGADQKMSSPEDDSDTKRLSKEEKGRSSCGRNFWVSGLSSTTRATDLKNLFSKYGKVVGA 435
E + +S DS+ + L K S S +A+D +N + +
Sbjct: 253 EDPPRHQAS---DSENEELPKPRISDSE-------SEDPPRNQASDSEN------EELPK 296
Query: 436 KVVTNARSPGARCYGFVTMSTAEEATKCINHLHKTELHGKMISVEKAKNEPVGKKTSDKR 495
V+++ S G + G + S E+A++ H K E S + + E G+ T +
Sbjct: 297 PRVSDSESEGPQ-KGPASDSETEDASR---HKQKPE------SDDDSDRENKGEDTEMQN 346
Query: 496 DS-------DGKKEKSSNSDRSTNLKRDDKCDRKDDAKKGDDGSGEKSK-----DQDDQK 543
DS D KK SS+S+ + K+ K D +D K+G++ K K D +D++
Sbjct: 347 DSFHSDSHMDRKKFHSSDSEEEEHKKQ--KMDSDEDEKEGEEEKVAKRKAAVLSDSEDEE 404
Query: 544 PGPSERSRATKSGSRGTERTVVMDKSKGVPVISVKTSGSKERASKSQDRKSASREKRSVV 603
+++SR S + ++ V DK SG +E+ S + A +E
Sbjct: 405 KASAKKSRVV-SDADDSDSDAVSDK-----------SGKREKTIASDSEEEAGKELS--- 449
Query: 604 SFDKVKEPRKSRDSESHSRVRERSEREQRMQAQWEREERERLEIARERLAFQRQRLERER 663
DK E + S+S S E + + EE E F ++ LE E+
Sbjct: 450 --DKKNEEKDLFGSDSESGNEEENLIADIFGESGDEEE-------EEFTGFNQEDLEEEK 500
Query: 664 MERERLERERMHVEHERRREQERIHREREELRRQQELRYEQERR 707
E + E E + +R + E+ Q++ +RR
Sbjct: 501 GETQVKEAEDSDSDDNIKRGKHMDFLSDFEMMLQRKKSMSGKRR 544
Score = 43.1 bits (100), Expect = 0.001
Identities = 69/325 (21%), Positives = 119/325 (36%), Gaps = 33/325 (10%)
Query: 480 EKAKNEPVGKKTSDKRDSDGKKEKSSNSDRSTNLKRDDKCDRKDDAKK-GDDGSGEKSK- 537
+ +EP+ SD + ++K S+S+ + +D + G D E+++
Sbjct: 68 DSENDEPLNLNASDSESEELHRQKDSDSESEERAEPPASDSENEDVNQHGSDSESEETRK 127
Query: 538 ------DQDDQKPGPSERSRATKSGSRGTERTVVMDKSKGVPVISVKTSGSKERASKSQD 591
+ ++ G + S G + + + K S + E A K Q
Sbjct: 128 LPGSDSENEELLNGHASDSENEDVGKHPASDSEIEELQK-----SPASDSETEDALKPQI 182
Query: 592 RKSASREK-RSVVSFDKVKEPRKSRDSESHSRVRER---SEREQRMQAQWEREERERLEI 647
S S E R S + +EP K R S+S S + S+ E + + + E E+
Sbjct: 183 SDSESEEPPRHQASDSENEEPPKPRMSDSESEELPKPQVSDSESEEPPRHQASDSENEEL 242
Query: 648 ARERLAFQRQ----RLERERMERERLERERMH-VEHERRREQERIHREREELRRQQELRY 702
+ R++ R + E E L + R+ E E + E EEL + +
Sbjct: 243 PKPRISDSESEDPPRHQASDSENEELPKPRISDSESEDPPRNQASDSENEELPKPRVSDS 302
Query: 703 EQERRPAVRRPYDLDRRDDA----YWPEAKRAALDERYHSDFNRQ-DRFHDFDHRDRGRY 757
E E + P +DA PE+ + E D Q D FH H DR ++
Sbjct: 303 ESEGPQ--KGPASDSETEDASRHKQKPESDDDSDRENKGEDTEMQNDSFHSDSHMDRKKF 360
Query: 758 PDHSVDRREGSRSMM----GEREGQ 778
+ E + M E+EG+
Sbjct: 361 HSSDSEEEEHKKQKMDSDEDEKEGE 385
>gi|42560244 peptidylprolyl isomerase G [Homo sapiens]
Length = 754
Score = 68.9 bits (167), Expect = 2e-11
Identities = 128/626 (20%), Positives = 233/626 (37%), Gaps = 69/626 (11%)
Query: 193 DTSSSDFTILQEIEEPSLEPENEKILDIL-GETCKSEPVKEESSELEQPFAQ----DTSS 247
DT+ S F I + P L+ + ++ G+ E +++ +PFA+
Sbjct: 118 DTNGSQFFITTK-PTPHLDGHHVVFGQVISGQEVVREIENQKTDAASKPFAEVRILSCGE 176
Query: 248 VGPDRKLAEEEDLFDSAHPEEGDLDLASESTAHAQSSKADSLLAVVKREPAEQPGDGERT 307
+ P K+ +EE + S+S++ +QSS S E +++ R
Sbjct: 177 LIPKSKVKKEEKKRHKSSSSSSSSSSDSDSSSDSQSSSDSSDSESATEEKSKKRKKKHRK 236
Query: 308 DCEPVGLEPAVEQSSAASELAEASSEELAEAPTEAPSPEA-------------------- 347
+ E + S S +E+ +E L P PE
Sbjct: 237 NSRKHKKEKKKRKKSKKSASSESEAENLEAQPQSTVRPEEIPPIPENRFLMRKSPPKADE 296
Query: 348 --RDSKEDGRKFDFDACNEVPPAPKESS--TSEGADQKMSSPEDDSDTKRLSKEEKGRSS 403
R ++E R+ + + N P + + T G K P R ++ R S
Sbjct: 297 KERKNRERERERECNPPNSQPASYQRRLLVTRSGRKIKGRGPRRYRTPSRSRSRDRFRRS 356
Query: 404 CGRNFWVSGLSSTTRA-TDLKNLFSKYGKVVGAKVVTNARSPGARCYGFVT-MSTAEEAT 461
W + R + K K ++ N RSP +T E+
Sbjct: 357 ETPPHWRQEMQRAQRMRVSSGERWIKGDKSELNEIKENQRSPVRVKERKITDHRNVSESP 416
Query: 462 KCINHLHKTELHGKMISVEK--AKNEPVGKKTSDKRDSDGK-KEKSSNSDRSTNLKRDDK 518
N K K S E+ +N K +K K K +S + ++S + +RD K
Sbjct: 417 NRKNEKEKKVKDHKSNSKERDIRRNSEKDDKYKNKVKKRAKSKSRSKSKEKSKSKERDSK 476
Query: 519 CDRKDDAKKGDDGSGEKSKDQDDQKPGPSERSRATKSGSRGTERTVVMDKSKGVPVISVK 578
+R ++ + S K +D ++ K E+ + + S + ER+ +KSK + S +
Sbjct: 477 HNRNEEKRMR---SRSKGRDHENVK----EKEKQSDSKGKDQERSRSKEKSKQLESKSNE 529
Query: 579 TSGSKERASKSQDRKSASREKRSVVSFDK------VKEPRKSRD------SESHSRVRER 626
SK SK +DR++ SR + ++ K +E +SRD S +H R R R
Sbjct: 530 HDHSK---SKEKDRRAQSRSRECDITKGKHSYNSRTRERSRSRDRSRRVRSRTHDRDRSR 586
Query: 627 SE-----REQRMQAQWEREERERLEIARERLAFQRQRLERERMERERLERERMHVEHERR 681
S+ REQ + + RER + R+R R+ ER E + + + R
Sbjct: 587 SKEYHRYREQEYRRRGRSRSRERRTPPGRSRSKDRRRRRRDSRSSEREESQSRNKDKYRN 646
Query: 682 REQERIHREREELRRQQELRYEQERRPAVRRPYDLDRRDDAYWPEAKRAALDERYHSDF- 740
+E + HR+ ++ ++ + RD + + + K+++ D S
Sbjct: 647 QESKSSHRKENSESEKRMYSKSRDHNSSNNSREKKADRDQSPFSKIKQSSQDNELKSSML 706
Query: 741 -NRQDR-----FHDFDHRDRGRYPDH 760
N++D + + +G+ DH
Sbjct: 707 KNKEDEKIRSSVEKENQKSKGQENDH 732
Score = 49.7 bits (117), Expect = 1e-05
Identities = 65/341 (19%), Positives = 132/341 (38%), Gaps = 34/341 (9%)
Query: 475 KMISVEKAKNEPVGKKTSDKRDSDGKKEKSSNSDRSTN-------LKRDDKCDRKDDAKK 527
K+ EK +++ +S DSD + S+SD S + K+ K RK+ K
Sbjct: 182 KVKKEEKKRHKSSSSSSSSSSDSDSSSDSQSSSDSSDSESATEEKSKKRKKKHRKNSRKH 241
Query: 528 GDDGSGEKSKDQDDQKPGPSERSRATKSGSRGTERTVVMDKSKGVPVISVKTSGSKERAS 587
+ K + +E A + E + +++ + S + KER +
Sbjct: 242 KKEKKKRKKSKKSASSESEAENLEAQPQSTVRPEEIPPIPENRFLMRKSPPKADEKERKN 301
Query: 588 KSQDR---------KSASREKRSVVSFD----KVKEPRKSR-DSESHSRVR-ERSEREQR 632
+ ++R + AS ++R +V+ K + PR+ R S S SR R RSE
Sbjct: 302 RERERERECNPPNSQPASYQRRLLVTRSGRKIKGRGPRRYRTPSRSRSRDRFRRSETPPH 361
Query: 633 MQAQWEREERERLEIARERLAFQRQRLERERMERERLERERMHVEHERRREQERIHRERE 692
+ + +R +R R+ + + L + + R + + R E +R+ E
Sbjct: 362 WRQEMQRAQRMRVSSGERWIKGDKSELNEIKENQRSPVRVKERKITDHRNVSESPNRKNE 421
Query: 693 ELRRQQELRYEQERRPAVRRPYDLDRRDDAYWPEAKRAALDERYHSDFNRQDRFHDFDHR 752
+ ++ ++ + + R R +DD Y + K+ A + + +
Sbjct: 422 KEKKVKDHKSNSKERDIRRN----SEKDDKYKNKVKKRAKSKSRSKSKEKS--------K 469
Query: 753 DRGRYPDHSVDRREGSRSMMGEREGQHYPERHGGPERHGRD 793
+ R H+ + + RS R+ ++ E+ + G+D
Sbjct: 470 SKERDSKHNRNEEKRMRSRSKGRDHENVKEKEKQSDSKGKD 510
Score = 43.1 bits (100), Expect = 0.001
Identities = 59/273 (21%), Positives = 109/273 (39%), Gaps = 39/273 (14%)
Query: 575 ISVKTSGSKERASKSQDRKSASREK---RSVVSFDK----VKEPRKSRD---SESHSRVR 624
+S + E+ K +D KS S+E+ R+ DK VK+ KS+ S+ S+ +
Sbjct: 412 VSESPNRKNEKEKKVKDHKSNSKERDIRRNSEKDDKYKNKVKKRAKSKSRSKSKEKSKSK 471
Query: 625 ERSER-----EQRMQAQWEREERERLEIARERLAFQRQRLERERMERERLERERMHVEHE 679
ER + E+RM+++ + + E ++ ++ + + ER R + + + E EH+
Sbjct: 472 ERDSKHNRNEEKRMRSRSKGRDHENVKEKEKQSDSKGKDQERSRSKEKSKQLESKSNEHD 531
Query: 680 RRREQERIHREREELRRQQELRYEQERRPAVRRPYDLDRRDDAYWPEAKRAALDERYHSD 739
+ +E+ R + R + + Y+ R+ + + R + D
Sbjct: 532 HSKSKEKDRRAQSRSRECDITK--------GKHSYNSRTRERSRSRDRSRRVRSRTHDRD 583
Query: 740 FNRQDRFHDFDHRDRGRYPDHSVDRREGSRSMMGEREGQHYPERHGGPERHGRDSRDGWG 799
+R +H RY + RR SRS ER R R RDSR
Sbjct: 584 RSRSKEYH--------RYREQEYRRRGRSRSR--ERRTPPGRSRSKDRRRRRRDSR---- 629
Query: 800 GYGSDKRMSEGRGLPPPPRRDWGDHGRREDDRS 832
S++ S+ R ++ R+E+ S
Sbjct: 630 --SSEREESQSRNKDKYRNQESKSSHRKENSES 660
Score = 42.0 bits (97), Expect = 0.003
Identities = 54/288 (18%), Positives = 104/288 (36%), Gaps = 61/288 (21%)
Query: 468 HKTELHGKMISVEKAKNEPVGKKTSDKRDSDGK-------KEKSSNSDRSTNLKRDDKCD 520
H +M S K ++ K+ + DS GK KEKS + +N K
Sbjct: 477 HNRNEEKRMRSRSKGRDHENVKEKEKQSDSKGKDQERSRSKEKSKQLESKSNEHDHSKSK 536
Query: 521 RKDDAKKGDDGSGEKSKDQDDQKPGPSERSRATKSGSRGTERTVVMDKSKGVPVISVKT- 579
KD + + +K + ERSR+ R RT D+S+ +
Sbjct: 537 EKDRRAQSRSRECDITKGKHSYNSRTRERSRSRDRSRRVRSRTHDRDRSRSKEYHRYREQ 596
Query: 580 -------------------SGSKERASKSQDRKSASREKRSVVSFDKVKEPR-------- 612
S SK+R + +D +S+ RE+ + DK +
Sbjct: 597 EYRRRGRSRSRERRTPPGRSRSKDRRRRRRDSRSSEREESQSRNKDKYRNQESKSSHRKE 656
Query: 613 ----------KSRDSESHSRVRERSEREQRMQAQWEREERERLEIARERLAFQRQRLERE 662
KSRD S + RE+ + +R++ ++ + + Q L+
Sbjct: 657 NSESEKRMYSKSRDHNSSNNSREK------------KADRDQSPFSKIKQSSQDNELKSS 704
Query: 663 RMERERLERERMHVEHERRR----EQERIHREREELRRQQELRYEQER 706
++ + E+ R VE E ++ E + +H + ++ + ++++
Sbjct: 705 MLKNKEDEKIRSSVEKENQKSKGQENDHVHEKNKKFDHESSPGTDEDK 752
>gi|148763347 cell division cycle 2-like 2 isoform 1 [Homo sapiens]
Length = 780
Score = 68.6 bits (166), Expect = 3e-11
Identities = 60/247 (24%), Positives = 107/247 (43%), Gaps = 21/247 (8%)
Query: 502 EKSSNSDRSTNLKRDDKCDRKDDAKKGDDGSGEKSKDQDDQKPGPSERS------RATKS 555
EK S ++ + +K RK+ +K + + S D+D ++ E T
Sbjct: 4 EKDSWKVKTLDEILQEKKRRKEQEEKAEIKRLKNSDDRDSKRDSLEEGELRDHCMEITIR 63
Query: 556 GSRGTERTVVMDKSKGVPVISVKTSGSKERASKSQDRKSASREKRSVVSFDKVKEPRKSR 615
S + D+ + +++K R K RK R+ +K + S
Sbjct: 64 NSPYRREDSMEDRGEEDDSLAIKPPQQMSRKEKVHHRKDEKRK-------EKCRHHSHSA 116
Query: 616 DSESHSRVRERSE------REQRMQAQWEREERERLEIARERLAFQRQRLERERMERERL 669
+ H+RV+ER RE++ +A+ E E ++R E+ARE +R RLE+ +ER+R
Sbjct: 117 EGGKHARVKEREHERRKRHREEQDKARREWERQKRREMAREHSRRERDRLEQ--LERKRE 174
Query: 670 ERERMHVEHERRREQERIHREREELRRQQELRYEQERRPAVRRPYDLDRRDDAYWPEAKR 729
+M + + +REQ+ R EE R+++E R E R D+ ++W +
Sbjct: 175 RERKMREQQKEQREQKERERRAEERRKEREARREVSAHHRTMREDYSDKVKASHWSRSPP 234
Query: 730 AALDERY 736
ER+
Sbjct: 235 RPPRERF 241
Score = 47.4 bits (111), Expect = 6e-05
Identities = 60/266 (22%), Positives = 97/266 (36%), Gaps = 18/266 (6%)
Query: 462 KCINHLHKTELHGKMISVEKAKNE--PVGKKTSDKRDSDGKKEKSSNSDRSTNLKRDDKC 519
KC +H H E GK V++ ++E ++ DK + +++K R + + D+
Sbjct: 108 KCRHHSHSAE-GGKHARVKEREHERRKRHREEQDKARREWERQKRREMAREHSRRERDRL 166
Query: 520 DRKDDAKKGDDGSGEKSKDQDDQKP--------GPSERSRATKSGSRGTERTVVMDKSKG 571
++ + ++ + E+ K+Q +QK +R S T R DK K
Sbjct: 167 EQLERKRERERKMREQQKEQREQKERERRAEERRKEREARREVSAHHRTMREDYSDKVKA 226
Query: 572 VPVISVKTSGSKERASKSQDRKSASREKRSVVSFDKVKEPRKSRDSESHSRVRERSEREQ 631
+ER RK EK + D + + + DSE + E S E
Sbjct: 227 SHWSRSPPRPPRERFELGDGRKPVKEEK--MEERDLLSDLQDISDSERKTSSAESSSAES 284
Query: 632 RMQAQWEREERERLEIARERLAFQRQRLERERMERERLERERMHVEHERRREQERIHRER 691
++ E EE E E E + + E E E E E E E EQ
Sbjct: 285 GSGSEEEEEEEEEEE---EEGSTSEESEEEEEEEEE--EEEETGSNSEEASEQSAEEVSE 339
Query: 692 EELRRQQELRYEQERRPAVRRPYDLD 717
EE+ +E E +D D
Sbjct: 340 EEMSEDEERENENHLLVVPESRFDRD 365
Score = 43.5 bits (101), Expect = 9e-04
Identities = 65/289 (22%), Positives = 115/289 (39%), Gaps = 28/289 (9%)
Query: 597 REKRSVVSFDKVKEPRKSRDSESHS----RVRERSEREQRMQAQWEREERER-LEIARER 651
++ V + D++ + +K R + R++ +R+ + + E E R+ +EI
Sbjct: 5 KDSWKVKTLDEILQEKKRRKEQEEKAEIKRLKNSDDRDSKRDSLEEGELRDHCMEITIRN 64
Query: 652 LAFQRQRLERERME----------RERLERERMHVE-HERRREQERIHREREELRRQQEL 700
++R+ +R E ++ +E++H E+R+E+ R H E + +
Sbjct: 65 SPYRREDSMEDRGEEDDSLAIKPPQQMSRKEKVHHRKDEKRKEKCRHHSHSAEGGKHARV 124
Query: 701 R-YEQERRPAVRRPYDLDRRDDAYWPEAKRAALDERYHSDFNRQDRFHDFDH-RDRGR-Y 757
+ E ERR R D RR+ W KR + R HS R DR + R+R R
Sbjct: 125 KEREHERRKRHREEQDKARRE---WERQKRREM-AREHSRRER-DRLEQLERKRERERKM 179
Query: 758 PDHSVDRREGSRSMMGEREGQHYPERHGGPERHGRDSRDGWGGYGSDKRMSEGRGLPPPP 817
+ ++RE E + E H R R+ + S PP
Sbjct: 180 REQQKEQREQKERERRAEERRKEREARREVSAHHRTMREDYSDKVKASHWSRSPPRPPRE 239
Query: 818 RRDWGDHGRR--EDDRSWQGTADGGMMD-RDHKRWQGGERSMSGHSGPG 863
R + GD GR+ ++++ + + D D +R S S SG G
Sbjct: 240 RFELGD-GRKPVKEEKMEERDLLSDLQDISDSERKTSSAESSSAESGSG 287
Score = 33.1 bits (74), Expect = 1.2
Identities = 58/273 (21%), Positives = 108/273 (39%), Gaps = 19/273 (6%)
Query: 35 RVIDLRAELRKRNVDSSGNKSVLMERLKK---AIEDEGGNPDEIEITSEGNKKTSKRSSK 91
RV + E RKR+ + ER K+ A E D +E ++ +R K
Sbjct: 123 RVKEREHERRKRHREEQDKARREWERQKRREMAREHSRRERDRLEQL----ERKRERERK 178
Query: 92 GRKPEEEGVEDNGLEENSGDGQEDVETSLENLQDIDIMDISVLDEAEIDNGSVADCVEDD 151
R+ ++E E E + + +++ E E M D+ + + S +
Sbjct: 179 MREQQKEQREQKERERRAEERRKEREARREVSAHHRTMREDYSDKVKASHWSRSPPRPPR 238
Query: 152 DADNLQESLSDSRELVEGEMKELPEQLQEHAIEDKETINNLDTSSSDFTILQEIEEPSLE 211
+ L + +E + E ++L LQ+ + +++T + +S+ + +E EE E
Sbjct: 239 ERFELGDGRKPVKE-EKMEERDLLSDLQDISDSERKTSSAESSSAESGSGSEEEEE---E 294
Query: 212 PENEKILDILGETCKSEPVKEESSELEQPFAQDTSSVGPDRKLAEEEDLFDSAHPEEGDL 271
E E+ E + E +EE E E + +S +++EEE D E L
Sbjct: 295 EEEEEEEGSTSEESEEEEEEEEEEEEETGSNSEEASEQSAEEVSEEEMSEDEERENENHL 354
Query: 272 DLASESTAHAQSSKADSLLAVVKREPAEQPGDG 304
+ ES S +++ E E+ G+G
Sbjct: 355 LVVPESRFDRDSGESE--------EAEEEVGEG 379
Score = 30.8 bits (68), Expect = 6.0
Identities = 38/170 (22%), Positives = 74/170 (43%), Gaps = 10/170 (5%)
Query: 31 LSDLRVIDLRAELRKRNVDSSGNKSVLMERLKKAIEDEGGNPDEIEITSEGNKKTSKRS- 89
L D+ + + + + SG+ S E ++ E+EG +E E E ++ + +
Sbjct: 264 LQDISDSERKTSSAESSSAESGSGSEEEEEEEEEEEEEGSTSEESEEEEEEEEEEEEETG 323
Query: 90 SKGRKPEEEGVEDNGLEENSGDGQEDVETSLENLQDIDI-MDISVLDEAEIDNGSVADCV 148
S + E+ E+ EE S D + + E L + + D +EAE + V +
Sbjct: 324 SNSEEASEQSAEEVSEEEMSEDEERENENHLLVVPESRFDRDSGESEEAEEE---VGEGT 380
Query: 149 EDDDADNLQESLSDSRELVEGEMK-ELPEQLQE----HAIEDKETINNLD 193
A + + DS L+ E+K ELP+ L ++E+ + +N ++
Sbjct: 381 PQSSALTEGDYVPDSPALLPIELKQELPKYLPALQGCRSVEEFQCLNRIE 430
Database: hs.faa
Posted date: Aug 4, 2009 4:42 PM
Number of letters in database: 18,247,518
Number of sequences in database: 37,866
Lambda K H
0.307 0.127 0.355
Gapped
Lambda K H
0.267 0.0410 0.140
Matrix: BLOSUM62
Gap Penalties: Existence: 11, Extension: 1
Number of Hits to DB: 38,890,342
Number of Sequences: 37866
Number of extensions: 2148933
Number of successful extensions: 33946
Number of sequences better than 10.0: 30
Number of HSP's better than 10.0 without gapping: 644
Number of HSP's successfully gapped in prelim test: 1290
Number of HSP's that attempted gapping in prelim test: 12222
Number of HSP's gapped (non-prelim): 9764
length of query: 915
length of database: 18,247,518
effective HSP length: 111
effective length of query: 804
effective length of database: 14,044,392
effective search space: 11291691168
effective search space used: 11291691168
T: 11
A: 40
X1: 16 ( 7.1 bits)
X2: 38 (14.6 bits)
X3: 64 (24.7 bits)
S1: 42 (21.6 bits)
S2: 67 (30.4 bits)
Search results were obtained with NCBI BLAST and RefSeq entries.
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Guide to the Human Genome
Copyright © 2010 by Stewart Scherer. All rights reserved.