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Search of human proteins with 21166359
BLASTP 2.2.11 [Jun-05-2005]
Reference: Altschul, Stephen F., Thomas L. Madden, Alejandro A. Schaffer,
Jinghui Zhang, Zheng Zhang, Webb Miller, and David J. Lipman (1997),
"Gapped BLAST and PSI-BLAST: a new generation of protein database search
programs", Nucleic Acids Res. 25:3389-3402.
Query= gi|21166359 G-protein-coupled receptor kinase 7 [Homo sapiens]
(553 letters)
Database: hs.faa
37,866 sequences; 18,247,518 total letters
Searching..................................................done
Score E
Sequences producing significant alignments: (bits) Value
gi|21166359 G-protein-coupled receptor kinase 7 [Homo sapiens] 1117 0.0
gi|51873043 G protein-coupled receptor kinase 4 isoform alpha [H... 493 e-139
gi|51896037 G protein-coupled receptor kinase 6 isoform C [Homo ... 484 e-136
gi|51896039 G protein-coupled receptor kinase 6 isoform A [Homo ... 484 e-136
gi|51896035 G protein-coupled receptor kinase 6 isoform B [Homo ... 484 e-136
gi|4506529 rhodopsin kinase [Homo sapiens] 483 e-136
gi|51873047 G protein-coupled receptor kinase 4 isoform gamma [H... 481 e-136
gi|4885349 G protein-coupled receptor kinase 5 [Homo sapiens] 476 e-134
gi|51873045 G protein-coupled receptor kinase 4 isoform beta [Ho... 472 e-133
gi|148539879 beta-adrenergic receptor kinase 2 [Homo sapiens] 268 1e-71
gi|148539876 beta-adrenergic receptor kinase 1 [Homo sapiens] 259 6e-69
gi|28557781 protein kinase C, eta [Homo sapiens] 191 2e-48
gi|5453974 protein kinase N2 [Homo sapiens] 187 2e-47
gi|4885563 protein kinase C, epsilon [Homo sapiens] 181 2e-45
gi|47157325 protein kinase C, delta [Homo sapiens] 178 1e-44
gi|31377782 protein kinase C, delta [Homo sapiens] 178 1e-44
gi|5453976 protein kinase C, theta [Homo sapiens] 176 7e-44
gi|47132591 protein kinase N1 isoform 1 [Homo sapiens] 174 1e-43
gi|47132589 protein kinase N1 isoform 2 [Homo sapiens] 174 1e-43
gi|4506067 protein kinase C, alpha [Homo sapiens] 174 2e-43
gi|133908623 protein kinase C, iota [Homo sapiens] 174 2e-43
gi|4506055 cAMP-dependent protein kinase catalytic subunit alpha... 173 3e-43
gi|46909584 cAMP-dependent protein kinase catalytic subunit alph... 172 9e-43
gi|55953117 ribosomal protein S6 kinase, 70kDa, polypeptide 2 [H... 171 2e-42
gi|4502023 AKT2 kinase [Homo sapiens] 170 3e-42
gi|75709228 protein kinase C, zeta isoform 2 [Homo sapiens] 170 4e-42
gi|75709226 protein kinase C, zeta isoform 2 [Homo sapiens] 170 4e-42
gi|52486327 protein kinase C, zeta isoform 1 [Homo sapiens] 170 4e-42
gi|47157322 protein kinase C, beta isoform 1 [Homo sapiens] 170 4e-42
gi|33636738 cAMP-dependent protein kinase catalytic subunit beta... 170 4e-42
>gi|21166359 G-protein-coupled receptor kinase 7 [Homo sapiens]
Length = 553
Score = 1117 bits (2888), Expect = 0.0
Identities = 553/553 (100%), Positives = 553/553 (100%)
Query: 1 MVDMGALDNLIANTAYLQARKPSDCDSKELQRRRRSLALPGLQGCAELRQKLSLNFHSLC 60
MVDMGALDNLIANTAYLQARKPSDCDSKELQRRRRSLALPGLQGCAELRQKLSLNFHSLC
Sbjct: 1 MVDMGALDNLIANTAYLQARKPSDCDSKELQRRRRSLALPGLQGCAELRQKLSLNFHSLC 60
Query: 61 EQQPIGRRLFRDFLATVPTFRKAATFLEDVQNWELAEEGPTKDSALQGLVATCASAPAPG 120
EQQPIGRRLFRDFLATVPTFRKAATFLEDVQNWELAEEGPTKDSALQGLVATCASAPAPG
Sbjct: 61 EQQPIGRRLFRDFLATVPTFRKAATFLEDVQNWELAEEGPTKDSALQGLVATCASAPAPG 120
Query: 121 NPQPFLSQAVATKCQAATTEEERVAAVTLAKAEAMAFLQEQPFKDFVTSAFYDKFLQWKL 180
NPQPFLSQAVATKCQAATTEEERVAAVTLAKAEAMAFLQEQPFKDFVTSAFYDKFLQWKL
Sbjct: 121 NPQPFLSQAVATKCQAATTEEERVAAVTLAKAEAMAFLQEQPFKDFVTSAFYDKFLQWKL 180
Query: 181 FEMQPVSDKYFTEFRVLGKGGFGEVCAVQVKNTGKMYACKKLDKKRLKKKGGEKMALLEK 240
FEMQPVSDKYFTEFRVLGKGGFGEVCAVQVKNTGKMYACKKLDKKRLKKKGGEKMALLEK
Sbjct: 181 FEMQPVSDKYFTEFRVLGKGGFGEVCAVQVKNTGKMYACKKLDKKRLKKKGGEKMALLEK 240
Query: 241 EILEKVSSPFIVSLAYAFESKTHLCLVMSLMNGGDLKFHIYNVGTRGLDMSRVIFYSAQI 300
EILEKVSSPFIVSLAYAFESKTHLCLVMSLMNGGDLKFHIYNVGTRGLDMSRVIFYSAQI
Sbjct: 241 EILEKVSSPFIVSLAYAFESKTHLCLVMSLMNGGDLKFHIYNVGTRGLDMSRVIFYSAQI 300
Query: 301 ACGMLHLHELGIVYRDMKPENVLLDDLGNCRLSDLGLAVEMKGGKPITQRAGTNGYMAPE 360
ACGMLHLHELGIVYRDMKPENVLLDDLGNCRLSDLGLAVEMKGGKPITQRAGTNGYMAPE
Sbjct: 301 ACGMLHLHELGIVYRDMKPENVLLDDLGNCRLSDLGLAVEMKGGKPITQRAGTNGYMAPE 360
Query: 361 ILMEKVSYSYPVDWFAMGCSIYEMVAGRTPFKDYKEKVSKEDLKQRTLQDEVKFQHDNFT 420
ILMEKVSYSYPVDWFAMGCSIYEMVAGRTPFKDYKEKVSKEDLKQRTLQDEVKFQHDNFT
Sbjct: 361 ILMEKVSYSYPVDWFAMGCSIYEMVAGRTPFKDYKEKVSKEDLKQRTLQDEVKFQHDNFT 420
Query: 421 EEAKDICRLFLAKKPEQRLGSREKSDDPRKHHFFKTINFPRLEAGLIEPPFVPDPSVVYA 480
EEAKDICRLFLAKKPEQRLGSREKSDDPRKHHFFKTINFPRLEAGLIEPPFVPDPSVVYA
Sbjct: 421 EEAKDICRLFLAKKPEQRLGSREKSDDPRKHHFFKTINFPRLEAGLIEPPFVPDPSVVYA 480
Query: 481 KDIAEIDDFSEVRGVEFDDKDKQFFKNFATGAVPIAWQEEIIETGLFEELNDPNRPTGCE 540
KDIAEIDDFSEVRGVEFDDKDKQFFKNFATGAVPIAWQEEIIETGLFEELNDPNRPTGCE
Sbjct: 481 KDIAEIDDFSEVRGVEFDDKDKQFFKNFATGAVPIAWQEEIIETGLFEELNDPNRPTGCE 540
Query: 541 EGNSSKSGVCLLL 553
EGNSSKSGVCLLL
Sbjct: 541 EGNSSKSGVCLLL 553
>gi|51873043 G protein-coupled receptor kinase 4 isoform alpha [Homo
sapiens]
Length = 578
Score = 493 bits (1270), Expect = e-139
Identities = 253/528 (47%), Positives = 348/528 (65%), Gaps = 7/528 (1%)
Query: 7 LDNLIANTAYLQARKPS-DCDSKELQRRRRSLALPGLQGCAELRQKLSLNFHSLCEQQPI 65
L+N++AN+ L+AR+ S ++ + L LP + C+ELR + ++ SLC++QPI
Sbjct: 3 LENIVANSLLLKARQGGYGKKSGRSKKWKEILTLPPVSQCSELRHSIEKDYSSLCDKQPI 62
Query: 66 GRRLFRDFLATVPTFRKAATFLEDVQNWELAEEGPTKDSALQGLVATCASAPAPGNPQPF 125
GRRLFR F T PT ++ FL+ V +E+A++ D L L A P P
Sbjct: 63 GRRLFRQFCDTKPTLKRHIEFLDAVAEYEVADDEDRSDCGLSILDRFFNDKLAA--PLPE 120
Query: 126 LSQAVATKCQAATTEEE-RVAAVTLAKAEAMAFLQEQPFKDFVTSAFYDKFLQWKLFEMQ 184
+ V T+C+ EE A A +L+ +PF+++ S+++ +FLQWK E Q
Sbjct: 121 IPPDVVTECRLGLKEENPSKKAFEECTRVAHNYLRGEPFEEYQESSYFSQFLQWKWLERQ 180
Query: 185 PVSDKYFTEFRVLGKGGFGEVCAVQVKNTGKMYACKKLDKKRLKKKGGEKMALLEKEILE 244
PV+ F +RVLGKGGFGEVCA QV+ TGKMYACKKL KKR+KK+ GE MAL EK ILE
Sbjct: 181 PVTKNTFRHYRVLGKGGFGEVCACQVRATGKMYACKKLQKKRIKKRKGEAMALNEKRILE 240
Query: 245 KVSSPFIVSLAYAFESKTHLCLVMSLMNGGDLKFHIYNVGTRGLDMSRVIFYSAQIACGM 304
KV S F+VSLAYA+E+K LCLV+++MNGGDLKFHIYN+G G D R +FY+A++ CG+
Sbjct: 241 KVQSRFVVSLAYAYETKDALCLVLTIMNGGDLKFHIYNLGNPGFDEQRAVFYAAELCCGL 300
Query: 305 LHLHELGIVYRDMKPENVLLDDLGNCRLSDLGLAVEMKGGKPITQRAGTNGYMAPEILME 364
L IVYRD+KPEN+LLDD G+ R+SDLGLA E+ G+ + R GT GYMAPE++
Sbjct: 301 EDLQRERIVYRDLKPENILLDDRGHIRISDLGLATEIPEGQRVRGRVGTVGYMAPEVVNN 360
Query: 365 KVSYSYPVDWFAMGCSIYEMVAGRTPFKDYKEKVSKEDLKQRTLQDEVKFQHDNFTEEAK 424
+ Y++ DW+ +GC IYEM+ G +PFK YKEKV E++ QR D ++ + F+E+AK
Sbjct: 361 E-KYTFSPDWWGLGCLIYEMIQGHSPFKKYKEKVKWEEVDQRIKNDTEEYS-EKFSEDAK 418
Query: 425 DICRLFLAKKPEQRLGSR-EKSDDPRKHHFFKTINFPRLEAGLIEPPFVPDPSVVYAKDI 483
ICR+ L K P +RLG R E + ++H FK INF RLEA ++EPPF PDP VY KD+
Sbjct: 419 SICRMLLTKNPSKRLGCRGEGAAGVKQHPVFKDINFRRLEANMLEPPFCPDPHAVYCKDV 478
Query: 484 AEIDDFSEVRGVEFDDKDKQFFKNFATGAVPIAWQEEIIETGLFEELN 531
+I+ FS V+G+ D D+ F+ FATG V I WQ E+IE+G F+++N
Sbjct: 479 LDIEQFSVVKGIYLDTADEDFYARFATGCVSIPWQNEMIESGCFKDIN 526
>gi|51896037 G protein-coupled receptor kinase 6 isoform C [Homo
sapiens]
Length = 560
Score = 484 bits (1245), Expect = e-136
Identities = 245/527 (46%), Positives = 350/527 (66%), Gaps = 6/527 (1%)
Query: 7 LDNLIANTAYLQARKPSDCDSKELQRR-RRSLALPGLQGCAELRQKLSLNFHSLCEQQPI 65
L+N++ANT L+AR+ + K ++ R+ L P + C ELR L ++HSLCE+QPI
Sbjct: 3 LENIVANTVLLKAREGGGGNRKGKSKKWRQMLQFPHISQCEELRLSLERDYHSLCERQPI 62
Query: 66 GRRLFRDFLATVPTFRKAATFLEDVQNWELAEEGPTKDSALQGLVATCASAPAPGNPQPF 125
GR LFR+F AT P + FL+ V +E+ + K Q L S P + P
Sbjct: 63 GRLLFREFCATRPELSRCVAFLDGVAEYEVTPDDKRKACGRQ-LTQNFLSHTGP-DLIPE 120
Query: 126 LSQAVATKCQAATTEEERVAAVTLAKAEAMAFLQEQPFKDFVTSAFYDKFLQWKLFEMQP 185
+ + + T C + +L PF D++ S ++++FLQWK E QP
Sbjct: 121 VPRQLVTNCTQRLEQGPCKDLFQELTRLTHEYLSVAPFADYLDSIYFNRFLQWKWLERQP 180
Query: 186 VSDKYFTEFRVLGKGGFGEVCAVQVKNTGKMYACKKLDKKRLKKKGGEKMALLEKEILEK 245
V+ F ++RVLGKGGFGEVCA QV+ TGKMYACKKL+KKR+KK+ GE MAL EK+ILEK
Sbjct: 181 VTKNTFRQYRVLGKGGFGEVCACQVRATGKMYACKKLEKKRIKKRKGEAMALNEKQILEK 240
Query: 246 VSSPFIVSLAYAFESKTHLCLVMSLMNGGDLKFHIYNVGTRGLDMSRVIFYSAQIACGML 305
V+S F+VSLAYA+E+K LCLV++LMNGGDLKFHIY++G G +R +FY+A+I CG+
Sbjct: 241 VNSRFVVSLAYAYETKDALCLVLTLMNGGDLKFHIYHMGQAGFPEARAVFYAAEICCGLE 300
Query: 306 HLHELGIVYRDMKPENVLLDDLGNCRLSDLGLAVEMKGGKPITQRAGTNGYMAPEILMEK 365
LH IVYRD+KPEN+LLDD G+ R+SDLGLAV + G+ I R GT GYMAPE++ +
Sbjct: 301 DLHRERIVYRDLKPENILLDDHGHIRISDLGLAVHVPEGQTIKGRVGTVGYMAPEVVKNE 360
Query: 366 VSYSYPVDWFAMGCSIYEMVAGRTPFKDYKEKVSKEDLKQRTLQDEVKFQHDNFTEEAKD 425
Y++ DW+A+GC +YEM+AG++PF+ K+K+ +E++ +R +++ + + F+ +A+
Sbjct: 361 -RYTFSPDWWALGCLLYEMIAGQSPFQQRKKKIKREEV-ERLVKEVPEEYSERFSPQARS 418
Query: 426 ICRLFLAKKPEQRLGSREKS-DDPRKHHFFKTINFPRLEAGLIEPPFVPDPSVVYAKDIA 484
+C L K P +RLG R S + ++H FK +NF RL AG++EPPF PDP +Y KD+
Sbjct: 419 LCSQLLCKDPAERLGCRGGSAREVKEHPLFKKLNFKRLGAGMLEPPFKPDPQAIYCKDVL 478
Query: 485 EIDDFSEVRGVEFDDKDKQFFKNFATGAVPIAWQEEIIETGLFEELN 531
+I+ FS V+GVE + D+ F++ FATG+VPI WQ E++ET F+ELN
Sbjct: 479 DIEQFSTVKGVELEPTDQDFYQKFATGSVPIPWQNEMVETECFQELN 525
>gi|51896039 G protein-coupled receptor kinase 6 isoform A [Homo
sapiens]
Length = 576
Score = 484 bits (1245), Expect = e-136
Identities = 245/527 (46%), Positives = 350/527 (66%), Gaps = 6/527 (1%)
Query: 7 LDNLIANTAYLQARKPSDCDSKELQRR-RRSLALPGLQGCAELRQKLSLNFHSLCEQQPI 65
L+N++ANT L+AR+ + K ++ R+ L P + C ELR L ++HSLCE+QPI
Sbjct: 3 LENIVANTVLLKAREGGGGNRKGKSKKWRQMLQFPHISQCEELRLSLERDYHSLCERQPI 62
Query: 66 GRRLFRDFLATVPTFRKAATFLEDVQNWELAEEGPTKDSALQGLVATCASAPAPGNPQPF 125
GR LFR+F AT P + FL+ V +E+ + K Q L S P + P
Sbjct: 63 GRLLFREFCATRPELSRCVAFLDGVAEYEVTPDDKRKACGRQ-LTQNFLSHTGP-DLIPE 120
Query: 126 LSQAVATKCQAATTEEERVAAVTLAKAEAMAFLQEQPFKDFVTSAFYDKFLQWKLFEMQP 185
+ + + T C + +L PF D++ S ++++FLQWK E QP
Sbjct: 121 VPRQLVTNCTQRLEQGPCKDLFQELTRLTHEYLSVAPFADYLDSIYFNRFLQWKWLERQP 180
Query: 186 VSDKYFTEFRVLGKGGFGEVCAVQVKNTGKMYACKKLDKKRLKKKGGEKMALLEKEILEK 245
V+ F ++RVLGKGGFGEVCA QV+ TGKMYACKKL+KKR+KK+ GE MAL EK+ILEK
Sbjct: 181 VTKNTFRQYRVLGKGGFGEVCACQVRATGKMYACKKLEKKRIKKRKGEAMALNEKQILEK 240
Query: 246 VSSPFIVSLAYAFESKTHLCLVMSLMNGGDLKFHIYNVGTRGLDMSRVIFYSAQIACGML 305
V+S F+VSLAYA+E+K LCLV++LMNGGDLKFHIY++G G +R +FY+A+I CG+
Sbjct: 241 VNSRFVVSLAYAYETKDALCLVLTLMNGGDLKFHIYHMGQAGFPEARAVFYAAEICCGLE 300
Query: 306 HLHELGIVYRDMKPENVLLDDLGNCRLSDLGLAVEMKGGKPITQRAGTNGYMAPEILMEK 365
LH IVYRD+KPEN+LLDD G+ R+SDLGLAV + G+ I R GT GYMAPE++ +
Sbjct: 301 DLHRERIVYRDLKPENILLDDHGHIRISDLGLAVHVPEGQTIKGRVGTVGYMAPEVVKNE 360
Query: 366 VSYSYPVDWFAMGCSIYEMVAGRTPFKDYKEKVSKEDLKQRTLQDEVKFQHDNFTEEAKD 425
Y++ DW+A+GC +YEM+AG++PF+ K+K+ +E++ +R +++ + + F+ +A+
Sbjct: 361 -RYTFSPDWWALGCLLYEMIAGQSPFQQRKKKIKREEV-ERLVKEVPEEYSERFSPQARS 418
Query: 426 ICRLFLAKKPEQRLGSREKS-DDPRKHHFFKTINFPRLEAGLIEPPFVPDPSVVYAKDIA 484
+C L K P +RLG R S + ++H FK +NF RL AG++EPPF PDP +Y KD+
Sbjct: 419 LCSQLLCKDPAERLGCRGGSAREVKEHPLFKKLNFKRLGAGMLEPPFKPDPQAIYCKDVL 478
Query: 485 EIDDFSEVRGVEFDDKDKQFFKNFATGAVPIAWQEEIIETGLFEELN 531
+I+ FS V+GVE + D+ F++ FATG+VPI WQ E++ET F+ELN
Sbjct: 479 DIEQFSTVKGVELEPTDQDFYQKFATGSVPIPWQNEMVETECFQELN 525
>gi|51896035 G protein-coupled receptor kinase 6 isoform B [Homo
sapiens]
Length = 589
Score = 484 bits (1245), Expect = e-136
Identities = 245/527 (46%), Positives = 350/527 (66%), Gaps = 6/527 (1%)
Query: 7 LDNLIANTAYLQARKPSDCDSKELQRR-RRSLALPGLQGCAELRQKLSLNFHSLCEQQPI 65
L+N++ANT L+AR+ + K ++ R+ L P + C ELR L ++HSLCE+QPI
Sbjct: 3 LENIVANTVLLKAREGGGGNRKGKSKKWRQMLQFPHISQCEELRLSLERDYHSLCERQPI 62
Query: 66 GRRLFRDFLATVPTFRKAATFLEDVQNWELAEEGPTKDSALQGLVATCASAPAPGNPQPF 125
GR LFR+F AT P + FL+ V +E+ + K Q L S P + P
Sbjct: 63 GRLLFREFCATRPELSRCVAFLDGVAEYEVTPDDKRKACGRQ-LTQNFLSHTGP-DLIPE 120
Query: 126 LSQAVATKCQAATTEEERVAAVTLAKAEAMAFLQEQPFKDFVTSAFYDKFLQWKLFEMQP 185
+ + + T C + +L PF D++ S ++++FLQWK E QP
Sbjct: 121 VPRQLVTNCTQRLEQGPCKDLFQELTRLTHEYLSVAPFADYLDSIYFNRFLQWKWLERQP 180
Query: 186 VSDKYFTEFRVLGKGGFGEVCAVQVKNTGKMYACKKLDKKRLKKKGGEKMALLEKEILEK 245
V+ F ++RVLGKGGFGEVCA QV+ TGKMYACKKL+KKR+KK+ GE MAL EK+ILEK
Sbjct: 181 VTKNTFRQYRVLGKGGFGEVCACQVRATGKMYACKKLEKKRIKKRKGEAMALNEKQILEK 240
Query: 246 VSSPFIVSLAYAFESKTHLCLVMSLMNGGDLKFHIYNVGTRGLDMSRVIFYSAQIACGML 305
V+S F+VSLAYA+E+K LCLV++LMNGGDLKFHIY++G G +R +FY+A+I CG+
Sbjct: 241 VNSRFVVSLAYAYETKDALCLVLTLMNGGDLKFHIYHMGQAGFPEARAVFYAAEICCGLE 300
Query: 306 HLHELGIVYRDMKPENVLLDDLGNCRLSDLGLAVEMKGGKPITQRAGTNGYMAPEILMEK 365
LH IVYRD+KPEN+LLDD G+ R+SDLGLAV + G+ I R GT GYMAPE++ +
Sbjct: 301 DLHRERIVYRDLKPENILLDDHGHIRISDLGLAVHVPEGQTIKGRVGTVGYMAPEVVKNE 360
Query: 366 VSYSYPVDWFAMGCSIYEMVAGRTPFKDYKEKVSKEDLKQRTLQDEVKFQHDNFTEEAKD 425
Y++ DW+A+GC +YEM+AG++PF+ K+K+ +E++ +R +++ + + F+ +A+
Sbjct: 361 -RYTFSPDWWALGCLLYEMIAGQSPFQQRKKKIKREEV-ERLVKEVPEEYSERFSPQARS 418
Query: 426 ICRLFLAKKPEQRLGSREKS-DDPRKHHFFKTINFPRLEAGLIEPPFVPDPSVVYAKDIA 484
+C L K P +RLG R S + ++H FK +NF RL AG++EPPF PDP +Y KD+
Sbjct: 419 LCSQLLCKDPAERLGCRGGSAREVKEHPLFKKLNFKRLGAGMLEPPFKPDPQAIYCKDVL 478
Query: 485 EIDDFSEVRGVEFDDKDKQFFKNFATGAVPIAWQEEIIETGLFEELN 531
+I+ FS V+GVE + D+ F++ FATG+VPI WQ E++ET F+ELN
Sbjct: 479 DIEQFSTVKGVELEPTDQDFYQKFATGSVPIPWQNEMVETECFQELN 525
>gi|4506529 rhodopsin kinase [Homo sapiens]
Length = 563
Score = 483 bits (1242), Expect = e-136
Identities = 270/572 (47%), Positives = 374/572 (65%), Gaps = 31/572 (5%)
Query: 2 VDMGALDNLIANTAYLQARKPSDCDSKELQRRRRSLA---LPGLQGCAELRQKLSLNFHS 58
+D G+L+ ++AN+A++ AR D S + R ++ LA LP L C LR LSL F S
Sbjct: 1 MDFGSLETVVANSAFIAARGSFDGSSSQPSRDKKYLAKLKLPPLSKCESLRDSLSLEFES 60
Query: 59 LCEQQPIGRRLFRDFLATVPTFRKAATFLEDVQNWELAEEGPTKDSALQGLVATCASAPA 118
+C +QPIG++LF+ FL + A L ++ W+ E+ T D+ LQ A A
Sbjct: 61 VCLEQPIGKKLFQQFL------QSAEKHLPALELWKDIEDYDTADNDLQPQKAQTILAQY 114
Query: 119 PGNPQP-----FLSQAVATKCQAATTEEERVAAVTLAKAEAMAFLQEQPFKDFVTSAFYD 173
+PQ FL + + K + E + L +A +A L + PF++++ S ++
Sbjct: 115 L-DPQAKLFCSFLDEGIVAKFKEGPVEIQDGLFQPLLQA-TLAHLGQAPFQEYLGSLYFL 172
Query: 174 KFLQWKLFEMQPVSDKYFTEFRVLGKGGFGEVCAVQVKNTGKMYACKKLDKKRLKKKGGE 233
+FLQWK E QP+ + +F +FRVLGKGGFGEV A Q+K TGK+YACKKL+KKRLKK+ G
Sbjct: 173 RFLQWKWLEAQPMGEDWFLDFRVLGKGGFGEVSACQMKATGKLYACKKLNKKRLKKRKGY 232
Query: 234 KMALLEKEILEKVSSPFIVSLAYAFESKTHLCLVMSLMNGGDLKFHIYNVGTR--GLDMS 291
+ A++EK+IL KV S FIVSLAYAFE+K LCLVM++MNGGD+++HIYNV G
Sbjct: 233 QGAMVEKKILMKVHSRFIVSLAYAFETKADLCLVMTIMNGGDIRYHIYNVNEENPGFPEP 292
Query: 292 RVIFYSAQIACGMLHLHELGIVYRDMKPENVLLDDLGNCRLSDLGLAVEMKGGKPITQ-R 350
R +FY+AQI CG+ HLH+ IVYRD+KPENVLLD+ GN R+SDLGLAVE+ G+ T+
Sbjct: 293 RALFYTAQIICGLEHLHQRRIVYRDLKPENVLLDNDGNVRISDLGLAVELLDGQSKTKGY 352
Query: 351 AGTNGYMAPEILMEKVSYSYPVDWFAMGCSIYEMVAGRTPFKDYKEKVSKEDLKQRTLQD 410
AGT G+MAPE+L + Y + VD+FA+G ++YEM+A R PF+ EKV ++LK R + +
Sbjct: 353 AGTPGFMAPELLQGE-EYDFSVDYFALGVTLYEMIAARGPFRARGEKVENKELKHRIISE 411
Query: 411 EVKFQHDNFTEEAKDICRLFLAKKPEQRLGSREKS-DDPRKHHFFKTINFPRLEAGLIEP 469
VK+ D F++ +KD C L K PE+RLG R+++ D R H FK +N+ +LEAG++ P
Sbjct: 412 PVKYP-DKFSQASKDFCEALLEKDPEKRLGFRDETCDKLRAHPLFKDLNWRQLEAGMLMP 470
Query: 470 PFVPDPSVVYAKDIAEIDDFSEVRGVEFDDKDKQFFKNFATGAVPIAWQEEIIETGLFEE 529
PF+PD VYAKDI ++ FS V+GV FD D +FF+ FATG PI WQEE+IETG+F E
Sbjct: 471 PFIPDSKTVYAKDIQDVGAFSTVKGVAFDKTDTEFFQEFATGNCPIPWQEEMIETGIFGE 530
Query: 530 LN-------DPNRPTGCEEG--NSSKSGVCLL 552
LN P+ G G +SSKSG+CL+
Sbjct: 531 LNVWRSDGQMPDDMKGISGGSSSSSKSGMCLV 562
>gi|51873047 G protein-coupled receptor kinase 4 isoform gamma [Homo
sapiens]
Length = 532
Score = 481 bits (1237), Expect = e-136
Identities = 248/517 (47%), Positives = 338/517 (65%), Gaps = 7/517 (1%)
Query: 7 LDNLIANTAYLQARKPS-DCDSKELQRRRRSLALPGLQGCAELRQKLSLNFHSLCEQQPI 65
L+N++AN+ L+AR+ S ++ + L LP + C+ELR + ++ SLC++QPI
Sbjct: 3 LENIVANSLLLKARQGGYGKKSGRSKKWKEILTLPPVSQCSELRHSIEKDYSSLCDKQPI 62
Query: 66 GRRLFRDFLATVPTFRKAATFLEDVQNWELAEEGPTKDSALQGLVATCASAPAPGNPQPF 125
GRRLFR F T PT ++ FL+ V +E+A++ D L L A P P
Sbjct: 63 GRRLFRQFCDTKPTLKRHIEFLDAVAEYEVADDEDRSDCGLSILDRFFNDKLAA--PLPE 120
Query: 126 LSQAVATKCQAATTEEE-RVAAVTLAKAEAMAFLQEQPFKDFVTSAFYDKFLQWKLFEMQ 184
+ V T+C+ EE A A +L+ +PF+++ S+++ +FLQWK E Q
Sbjct: 121 IPPDVVTECRLGLKEENPSKKAFEECTRVAHNYLRGEPFEEYQESSYFSQFLQWKWLERQ 180
Query: 185 PVSDKYFTEFRVLGKGGFGEVCAVQVKNTGKMYACKKLDKKRLKKKGGEKMALLEKEILE 244
PV+ F +RVLGKGGFGEVCA QV+ TGKMYACKKL KKR+KK+ GE MAL EK ILE
Sbjct: 181 PVTKNTFRHYRVLGKGGFGEVCACQVRATGKMYACKKLQKKRIKKRKGEAMALNEKRILE 240
Query: 245 KVSSPFIVSLAYAFESKTHLCLVMSLMNGGDLKFHIYNVGTRGLDMSRVIFYSAQIACGM 304
KV S F+VSLAYA+E+K LCLV+++MNGGDLKFHIYN+G G D R +FY+A++ CG+
Sbjct: 241 KVQSRFVVSLAYAYETKDALCLVLTIMNGGDLKFHIYNLGNPGFDEQRAVFYAAELCCGL 300
Query: 305 LHLHELGIVYRDMKPENVLLDDLGNCRLSDLGLAVEMKGGKPITQRAGTNGYMAPEILME 364
L IVYRD+KPEN+LLDD G+ R+SDLGLA E+ G+ + R GT GYMAPE++
Sbjct: 301 EDLQRERIVYRDLKPENILLDDRGHIRISDLGLATEIPEGQRVRGRVGTVGYMAPEVVNN 360
Query: 365 KVSYSYPVDWFAMGCSIYEMVAGRTPFKDYKEKVSKEDLKQRTLQDEVKFQHDNFTEEAK 424
+ Y++ DW+ +GC IYEM+ G +PFK YKEKV E++ QR D ++ + F+E+AK
Sbjct: 361 E-KYTFSPDWWGLGCLIYEMIQGHSPFKKYKEKVKWEEVDQRIKNDTEEYS-EKFSEDAK 418
Query: 425 DICRLFLAKKPEQRLGSR-EKSDDPRKHHFFKTINFPRLEAGLIEPPFVPDPSVVYAKDI 483
ICR+ L K P +RLG R E + ++H FK INF RLEA ++EPPF PDP VY KD+
Sbjct: 419 SICRMLLTKNPSKRLGCRGEGAAGVKQHPVFKDINFRRLEANMLEPPFCPDPHAVYCKDV 478
Query: 484 AEIDDFSEVRGVEFDDKDKQFFKNFATGAVPIAWQEE 520
+I+ FS V+G+ D D+ F+ FATG V I WQ E
Sbjct: 479 LDIEQFSVVKGIYLDTADEDFYARFATGCVSIPWQNE 515
>gi|4885349 G protein-coupled receptor kinase 5 [Homo sapiens]
Length = 590
Score = 476 bits (1226), Expect = e-134
Identities = 240/527 (45%), Positives = 347/527 (65%), Gaps = 6/527 (1%)
Query: 7 LDNLIANTAYLQARKPSDCDSKELQRR-RRSLALPGLQGCAELRQKLSLNFHSLCEQQPI 65
L+N++ANT L+AR+ K ++ + L P + C +LR+ + ++ SLC++QPI
Sbjct: 3 LENIVANTVLLKAREGGGGKRKGKSKKWKEILKFPHISQCEDLRRTIDRDYCSLCDKQPI 62
Query: 66 GRRLFRDFLATVPTFRKAATFLEDVQNWELAEEGPTKDSALQGLVATCASAPAPGNPQPF 125
GR LFR F T P FL+ V +E+ + + + + T P
Sbjct: 63 GRLLFRQFCETRPGLECYIQFLDSVAEYEVTPDEKLGEKGKE--IMTKYLTPKSPVFIAQ 120
Query: 126 LSQAVATKCQAATTEEERVAAVTLAKAEAMAFLQEQPFKDFVTSAFYDKFLQWKLFEMQP 185
+ Q + ++ + ++ + +L+ +PF +++ S F+D+FLQWK E QP
Sbjct: 121 VGQDLVSQTEEKLLQKPCKELFSACAQSVHEYLRGEPFHEYLDSMFFDRFLQWKWLERQP 180
Query: 186 VSDKYFTEFRVLGKGGFGEVCAVQVKNTGKMYACKKLDKKRLKKKGGEKMALLEKEILEK 245
V+ F ++RVLGKGGFGEVCA QV+ TGKMYACK+L+KKR+KK+ GE MAL EK+ILEK
Sbjct: 181 VTKNTFRQYRVLGKGGFGEVCACQVRATGKMYACKRLEKKRIKKRKGESMALNEKQILEK 240
Query: 246 VSSPFIVSLAYAFESKTHLCLVMSLMNGGDLKFHIYNVGTRGLDMSRVIFYSAQIACGML 305
V+S F+V+LAYA+E+K LCLV+++MNGGDLKFHIYN+G G + R +FY+A+I CG+
Sbjct: 241 VNSQFVVNLAYAYETKDALCLVLTIMNGGDLKFHIYNMGNPGFEEERALFYAAEILCGLE 300
Query: 306 HLHELGIVYRDMKPENVLLDDLGNCRLSDLGLAVEMKGGKPITQRAGTNGYMAPEILMEK 365
LH VYRD+KPEN+LLDD G+ R+SDLGLAV++ G I R GT GYMAPE+L +
Sbjct: 301 DLHRENTVYRDLKPENILLDDYGHIRISDLGLAVKIPEGDLIRGRVGTVGYMAPEVLNNQ 360
Query: 366 VSYSYPVDWFAMGCSIYEMVAGRTPFKDYKEKVSKEDLKQRTLQDEVKFQHDNFTEEAKD 425
Y D++ +GC IYEM+ G++PF+ KEKV +E++ +R L+ E + H F+EEAK
Sbjct: 361 -RYGLSPDYWGLGCLIYEMIEGQSPFRGRKEKVKREEVDRRVLETEEVYSH-KFSEEAKS 418
Query: 426 ICRLFLAKKPEQRLGSREK-SDDPRKHHFFKTINFPRLEAGLIEPPFVPDPSVVYAKDIA 484
IC++ L K +QRLG +E+ + + ++H FF+ +NF RLEAG+++PPFVPDP VY KD+
Sbjct: 419 ICKMLLTKDAKQRLGCQEEGAAEVKRHPFFRNMNFKRLEAGMLDPPFVPDPRAVYCKDVL 478
Query: 485 EIDDFSEVRGVEFDDKDKQFFKNFATGAVPIAWQEEIIETGLFEELN 531
+I+ FS V+GV D D F+ F+TG+V I WQ E+IET F+ELN
Sbjct: 479 DIEQFSTVKGVNLDHTDDDFYSKFSTGSVSIPWQNEMIETECFKELN 525
>gi|51873045 G protein-coupled receptor kinase 4 isoform beta [Homo
sapiens]
Length = 546
Score = 472 bits (1215), Expect = e-133
Identities = 239/486 (49%), Positives = 324/486 (66%), Gaps = 6/486 (1%)
Query: 48 LRQKLSLNFHSLCEQQPIGRRLFRDFLATVPTFRKAATFLEDVQNWELAEEGPTKDSALQ 107
L+ + ++ SLC++QPIGRRLFR F T PT ++ FL+ V +E+A++ D L
Sbjct: 13 LKARQEKDYSSLCDKQPIGRRLFRQFCDTKPTLKRHIEFLDAVAEYEVADDEDRSDCGLS 72
Query: 108 GLVATCASAPAPGNPQPFLSQAVATKCQAATTEEE-RVAAVTLAKAEAMAFLQEQPFKDF 166
L A P P + V T+C+ EE A A +L+ +PF+++
Sbjct: 73 ILDRFFNDKLAA--PLPEIPPDVVTECRLGLKEENPSKKAFEECTRVAHNYLRGEPFEEY 130
Query: 167 VTSAFYDKFLQWKLFEMQPVSDKYFTEFRVLGKGGFGEVCAVQVKNTGKMYACKKLDKKR 226
S+++ +FLQWK E QPV+ F +RVLGKGGFGEVCA QV+ TGKMYACKKL KKR
Sbjct: 131 QESSYFSQFLQWKWLERQPVTKNTFRHYRVLGKGGFGEVCACQVRATGKMYACKKLQKKR 190
Query: 227 LKKKGGEKMALLEKEILEKVSSPFIVSLAYAFESKTHLCLVMSLMNGGDLKFHIYNVGTR 286
+KK+ GE MAL EK ILEKV S F+VSLAYA+E+K LCLV+++MNGGDLKFHIYN+G
Sbjct: 191 IKKRKGEAMALNEKRILEKVQSRFVVSLAYAYETKDALCLVLTIMNGGDLKFHIYNLGNP 250
Query: 287 GLDMSRVIFYSAQIACGMLHLHELGIVYRDMKPENVLLDDLGNCRLSDLGLAVEMKGGKP 346
G D R +FY+A++ CG+ L IVYRD+KPEN+LLDD G+ R+SDLGLA E+ G+
Sbjct: 251 GFDEQRAVFYAAELCCGLEDLQRERIVYRDLKPENILLDDRGHIRISDLGLATEIPEGQR 310
Query: 347 ITQRAGTNGYMAPEILMEKVSYSYPVDWFAMGCSIYEMVAGRTPFKDYKEKVSKEDLKQR 406
+ R GT GYMAPE++ + Y++ DW+ +GC IYEM+ G +PFK YKEKV E++ QR
Sbjct: 311 VRGRVGTVGYMAPEVVNNE-KYTFSPDWWGLGCLIYEMIQGHSPFKKYKEKVKWEEVDQR 369
Query: 407 TLQDEVKFQHDNFTEEAKDICRLFLAKKPEQRLGSR-EKSDDPRKHHFFKTINFPRLEAG 465
D ++ + F+E+AK ICR+ L K P +RLG R E + ++H FK INF RLEA
Sbjct: 370 IKNDTEEYS-EKFSEDAKSICRMLLTKNPSKRLGCRGEGAAGVKQHPVFKDINFRRLEAN 428
Query: 466 LIEPPFVPDPSVVYAKDIAEIDDFSEVRGVEFDDKDKQFFKNFATGAVPIAWQEEIIETG 525
++EPPF PDP VY KD+ +I+ FS V+G+ D D+ F+ FATG V I WQ E+IE+G
Sbjct: 429 MLEPPFCPDPHAVYCKDVLDIEQFSVVKGIYLDTADEDFYARFATGCVSIPWQNEMIESG 488
Query: 526 LFEELN 531
F+++N
Sbjct: 489 CFKDIN 494
>gi|148539879 beta-adrenergic receptor kinase 2 [Homo sapiens]
Length = 688
Score = 268 bits (685), Expect = 1e-71
Identities = 172/538 (31%), Positives = 280/538 (52%), Gaps = 18/538 (3%)
Query: 4 MGALDNLIANTAYLQARKPSDCDSKELQRRRRSLALPGLQGCAE--LRQKLSLNFHSLCE 61
M L+ ++A+ +YL A + S +R L P ++ + L ++ + F +
Sbjct: 1 MADLEAVLADVSYLMAMEKSKATPAARASKRIVLPEPSIRSVMQKYLAERNEITFDKIFN 60
Query: 62 QQPIGRRLFRDF-LATVPTFRKAATFLEDVQNWELAEEGPTKDSALQGLVATCASAPAPG 120
Q+ IG LF+DF L + F E+++ +E + + + +
Sbjct: 61 QK-IGFLLFKDFCLNEINEAVPQVKFYEEIKEYEKLDNEEDRLCRSRQIYDAYIMKELLS 119
Query: 121 NPQPFLSQAVATKCQAATTEEERVAAVTLAKAEAMAFLQEQPFKDFVTSAFYDKFLQWKL 180
PF QAV + ++ E L+ F+ F+ S + +F QWK
Sbjct: 120 CSHPFSKQAVEHVQSHLSKKQVTSTLFQPYIEEICESLRGDIFQKFMESDKFTRFCQWKN 179
Query: 181 FEMQ-PVSDKYFTEFRVLGKGGFGEVCAVQVKNTGKMYACKKLDKKRLKKKGGEKMALLE 239
E+ ++ F+ R++G+GGFGEV + +TGKMYA K LDKKR+K K GE +AL E
Sbjct: 180 VELNIHLTMNEFSVHRIIGRGGFGEVYGCRKADTGKMYAMKCLDKKRIKMKQGETLALNE 239
Query: 240 KEILEKVSS---PFIVSLAYAFESKTHLCLVMSLMNGGDLKFHIYNVGTRGLDMSRVIFY 296
+ +L VS+ PFIV + YAF + LC ++ LMNGGDL +H+ G + FY
Sbjct: 240 RIMLSLVSTGDCPFIVCMTYAFHTPDKLCFILDLMNGGDLHYHLSQHGV--FSEKEMRFY 297
Query: 297 SAQIACGMLHLHELGIVYRDMKPENVLLDDLGNCRLSDLGLAVEMKGGKPITQRAGTNGY 356
+ +I G+ H+H +VYRD+KP N+LLD+ G+ R+SDLGLA + KP GT+GY
Sbjct: 298 ATEIILGLEHMHNRFVVYRDLKPANILLDEHGHARISDLGLACDFSKKKPHAS-VGTHGY 356
Query: 357 MAPEILMEKVSYSYPVDWFAMGCSIYEMVAGRTPFKDYKEKVSKEDLKQRTLQDEVKFQH 416
MAPE+L + +Y DWF++GC +++++ G +PF+ +K K K ++ + TL V+
Sbjct: 357 MAPEVLQKGTAYDSSADWFSLGCMLFKLLRGHSPFRQHKTK-DKHEIDRMTLTVNVELP- 414
Query: 417 DNFTEEAKDICRLFLAKKPEQRLGSR-EKSDDPRKHHFFKTINFPRLEAGLIEPPFVPDP 475
D F+ E K + L + +RLG S + ++H FFK +++ + PP +P
Sbjct: 415 DTFSPELKSLLEGLLQRDVSKRLGCHGGGSQEVKEHSFFKGVDWQHVYLQKYPPPLIPPR 474
Query: 476 SVVYAKDIAEIDDFSE--VRGVEFDDKDKQFFKNFATGAVPIAWQEEIIETGLFEELN 531
V A D +I F E +G++ D D++ +KNF + WQ+E+ ET ++E +N
Sbjct: 475 GEVNAADAFDIGSFDEEDTKGIKLLDCDQELYKNFPL-VISERWQQEVTET-VYEAVN 530
>gi|148539876 beta-adrenergic receptor kinase 1 [Homo sapiens]
Length = 689
Score = 259 bits (661), Expect = 6e-69
Identities = 168/539 (31%), Positives = 290/539 (53%), Gaps = 20/539 (3%)
Query: 4 MGALDNLIANTAYLQARKPSDCDSKELQRRRRSLALPGLQGCAE--LRQKLSLNFHSLCE 61
M L+ ++A+ +YL A + S ++ L P ++ + L + + F +
Sbjct: 1 MADLEAVLADVSYLMAMEKSKATPAARASKKILLPEPSIRSVMQKYLEDRGEVTFEKIFS 60
Query: 62 QQPIGRRLFRDF-LATVPTFRKAATFLEDVQNWELAEEGPTKDSALQGLVATCASAPAPG 120
Q+ +G LFRDF L + R F E+++ +E E + + + + +
Sbjct: 61 QK-LGYLLFRDFCLNHLEEARPLVEFYEEIKKYEKLETEEERVARSREIFDSYIMKELLA 119
Query: 121 NPQPFLSQAVATKCQAATTEEERVAAVTLAKAEAMAF-LQEQPFKDFVTSAFYDKFLQWK 179
PF S++ Q +++ + E + L+ F+ F+ S + +F QWK
Sbjct: 120 CSHPF-SKSATEHVQGHLGKKQVPPDLFQPYIEEICQNLRGDVFQKFIESDKFTRFCQWK 178
Query: 180 LFEMQ-PVSDKYFTEFRVLGKGGFGEVCAVQVKNTGKMYACKKLDKKRLKKKGGEKMALL 238
E+ ++ F+ R++G+GGFGEV + +TGKMYA K LDKKR+K K GE +AL
Sbjct: 179 NVELNIHLTMNDFSVHRIIGRGGFGEVYGCRKADTGKMYAMKCLDKKRIKMKQGETLALN 238
Query: 239 EKEILEKVSS---PFIVSLAYAFESKTHLCLVMSLMNGGDLKFHIYNVGTRGLDMSRVIF 295
E+ +L VS+ PFIV ++YAF + L ++ LMNGGDL +H+ G + + F
Sbjct: 239 ERIMLSLVSTGDCPFIVCMSYAFHTPDKLSFILDLMNGGDLHYHLSQHGV--FSEADMRF 296
Query: 296 YSAQIACGMLHLHELGIVYRDMKPENVLLDDLGNCRLSDLGLAVEMKGGKPITQRAGTNG 355
Y+A+I G+ H+H +VYRD+KP N+LLD+ G+ R+SDLGLA + KP GT+G
Sbjct: 297 YAAEIILGLEHMHNRFVVYRDLKPANILLDEHGHVRISDLGLACDFSKKKPHAS-VGTHG 355
Query: 356 YMAPEILMEKVSYSYPVDWFAMGCSIYEMVAGRTPFKDYKEKVSKEDLKQRTLQDEVKFQ 415
YMAPE+L + V+Y DWF++GC +++++ G +PF+ +K K K ++ + TL V+
Sbjct: 356 YMAPEVLQKGVAYDSSADWFSLGCMLFKLLRGHSPFRQHKTK-DKHEIDRMTLTMAVELP 414
Query: 416 HDNFTEEAKDICRLFLAKKPEQRLGSREK-SDDPRKHHFFKTINFPRLEAGLIEPPFVPD 474
D+F+ E + + L + +RLG + + + ++ FF+++++ + PP +P
Sbjct: 415 -DSFSPELRSLLEGLLQRDVNRRLGCLGRGAQEVKESPFFRSLDWQMVFLQKYPPPLIPP 473
Query: 475 PSVVYAKDIAEIDDFSE--VRGVEFDDKDKQFFKNFATGAVPIAWQEEIIETGLFEELN 531
V A D +I F E +G++ D D++ ++NF + WQ+E+ ET +F+ +N
Sbjct: 474 RGEVNAADAFDIGSFDEEDTKGIKLLDSDQELYRNFPL-TISERWQQEVAET-VFDTIN 530
>gi|28557781 protein kinase C, eta [Homo sapiens]
Length = 683
Score = 191 bits (484), Expect = 2e-48
Identities = 118/301 (39%), Positives = 168/301 (55%), Gaps = 14/301 (4%)
Query: 191 FTEFRVLGKGGFGEVCAVQVKNTGKMYACKKLDKKRLKKKGGEKMALLEKEILEKVSS-P 249
F RVLGKG FG+V +VK TG +YA K L K + + + + EK IL + P
Sbjct: 355 FEFIRVLGKGSFGKVMLARVKETGDLYAVKVLKKDVILQDDDVECTMTEKRILSLARNHP 414
Query: 250 FIVSLAYAFESKTHLCLVMSLMNGGDLKFHIYNVGTRGLDMSRVIFYSAQIACGMLHLHE 309
F+ L F++ L VM +NGGDL FHI +R D +R FY+A+I ++ LH+
Sbjct: 415 FLTQLFCCFQTPDRLFFVMEFVNGGDLMFHIQK--SRRFDEARARFYAAEIISALMFLHD 472
Query: 310 LGIVYRDMKPENVLLDDLGNCRLSDLGLAVE-MKGGKPITQRAGTNGYMAPEILMEKVSY 368
GI+YRD+K +NVLLD G+C+L+D G+ E + G GT Y+APEIL E + Y
Sbjct: 473 KGIIYRDLKLDNVLLDHEGHCKLADFGMCKEGICNGVTTATFCGTPDYIAPEILQEML-Y 531
Query: 369 SYPVDWFAMGCSIYEMVAGRTPFKDYKEKVSKEDLKQRTLQDEVKFQHDNFTEEAKDICR 428
VDW+AMG +YEM+ G PF E +++DL + L DEV + E+A I +
Sbjct: 532 GPAVDWWAMGVLLYEMLCGHAPF----EAENEDDLFEAILNDEVVYP-TWLHEDATGILK 586
Query: 429 LFLAKKPEQRLGSREKSDDPR--KHHFFKTINFPRLEAGLIEPPFVPDPSVVYAKDIAEI 486
F+ K P RLGS + + +H FFK I++ +L IEPPF P + +D++
Sbjct: 587 SFMTKNPTMRLGSLTQGGEHAILRHPFFKEIDWAQLNHRQIEPPF--RPRIKSREDVSNF 644
Query: 487 D 487
D
Sbjct: 645 D 645
>gi|5453974 protein kinase N2 [Homo sapiens]
Length = 984
Score = 187 bits (476), Expect = 2e-47
Identities = 114/298 (38%), Positives = 172/298 (57%), Gaps = 16/298 (5%)
Query: 196 VLGKGGFGEVCAVQVKNTGKMYACKKLDKKRLKKKGGEKMALLEKEILEKVSS---PFIV 252
VLG+G FG+V + KNT +M+A K L K + + + EK I E V+S PF+V
Sbjct: 662 VLGRGHFGKVLLAEYKNTNEMFAIKALKKGDIVARDEVDSLMCEKRIFETVNSVRHPFLV 721
Query: 253 SLAYAFESKTHLCLVMSLMNGGDLKFHIYNVGTRGLDMSRVIFYSAQIACGMLHLHELGI 312
+L F++K H+C VM GGDL HI+ T R +FY+A + G+ +LHE I
Sbjct: 722 NLFACFQTKEHVCFVMEYAAGGDLMMHIH---TDVFSEPRAVFYAACVVLGLQYLHEHKI 778
Query: 313 VYRDMKPENVLLDDLGNCRLSDLGLAVEMKG-GKPITQRAGTNGYMAPEILMEKVSYSYP 371
VYRD+K +N+LLD G +++D GL E G G + GT ++APE+L E SY+
Sbjct: 779 VYRDLKLDNLLLDTEGFVKIADFGLCKEGMGYGDRTSTFCGTPEFLAPEVLTE-TSYTRA 837
Query: 372 VDWFAMGCSIYEMVAGRTPFKDYKEKVSKEDLKQRTLQDEVKFQHDNFTEEAKDICRLFL 431
VDW+ +G IYEM+ G +PF E E++ + DEV++ + EA I R L
Sbjct: 838 VDWWGLGVLIYEMLVGESPFPGDDE----EEVFDSIVNDEVRYPR-FLSTEAISIMRRLL 892
Query: 432 AKKPEQRLGSREK-SDDPRKHHFFKTINFPRLEAGLIEPPFVPDPSVVYAKDIAEIDD 488
+ PE+RLG+ EK ++D +KH FF+ I++ L ++PPF+ P++ +D++ DD
Sbjct: 893 RRNPERRLGASEKDAEDVKKHPFFRLIDWSALMDKKVKPPFI--PTIRGREDVSNFDD 948
>gi|4885563 protein kinase C, epsilon [Homo sapiens]
Length = 737
Score = 181 bits (458), Expect = 2e-45
Identities = 113/306 (36%), Positives = 172/306 (56%), Gaps = 16/306 (5%)
Query: 191 FTEFRVLGKGGFGEVCAVQVKNTGKMYACKKLDKKRLKKKGGEKMALLEKEILEKVSS-P 249
F +VLGKG FG+V ++K ++YA K L K + + + EK IL P
Sbjct: 408 FNFIKVLGKGSFGKVMLAELKGKDEVYAVKVLKKDVILQDDDVDCTMTEKRILALARKHP 467
Query: 250 FIVSLAYAFESKTHLCLVMSLMNGGDLKFHIYNVGTRGLDMSRVIFYSAQIACGMLHLHE 309
++ L F++K L VM +NGGDL F I +R D R FY+A++ ++ LH+
Sbjct: 468 YLTQLYCCFQTKDRLFFVMEYVNGGDLMFQIQR--SRKFDEPRSRFYAAEVTSALMFLHQ 525
Query: 310 LGIVYRDMKPENVLLDDLGNCRLSDLGLAVE-MKGGKPITQRAGTNGYMAPEILMEKVSY 368
G++YRD+K +N+LLD G+C+L+D G+ E + G T GT Y+APEIL E + Y
Sbjct: 526 HGVIYRDLKLDNILLDAEGHCKLADFGMCKEGILNGVTTTTFCGTPDYIAPEILQE-LEY 584
Query: 369 SYPVDWFAMGCSIYEMVAGRTPFKDYKEKVSKEDLKQRTLQDEVKFQHDNFTEEAKDICR 428
VDW+A+G +YEM+AG+ PF E +++DL + L D+V + ++EA I +
Sbjct: 585 GPSVDWWALGVLMYEMMAGQPPF----EADNEDDLFESILHDDVLYP-VWLSKEAVSILK 639
Query: 429 LFLAKKPEQRLG---SREKSDDPRKHHFFKTINFPRLEAGLIEPPFVPDPSVVYAKDIAE 485
F+ K P +RLG S+ D ++H FFK I++ LE I+PPF P + +D+
Sbjct: 640 AFMTKNPHKRLGCVASQNGEDAIKQHPFFKEIDWVLLEQKKIKPPF--KPRIKTKRDVNN 697
Query: 486 ID-DFS 490
D DF+
Sbjct: 698 FDQDFT 703
>gi|47157325 protein kinase C, delta [Homo sapiens]
Length = 676
Score = 178 bits (452), Expect = 1e-44
Identities = 110/315 (34%), Positives = 175/315 (55%), Gaps = 17/315 (5%)
Query: 191 FTEFRVLGKGGFGEVCAVQVKNTGKMYACKKLDKKRLKKKGGEKMALLEKEILEKVS-SP 249
F +VLGKG FG+V ++K G+ +A K L K + + ++EK +L + +P
Sbjct: 349 FIFHKVLGKGSFGKVLLGELKGRGEYFAIKALKKDVVLIDDDVECTMVEKRVLTLAAENP 408
Query: 250 FIVSLAYAFESKTHLCLVMSLMNGGDLKFHIYNVGTRGLDMSRVIFYSAQIACGMLHLHE 309
F+ L F++K HL VM +NGGDL +HI + G ++ R FY+A+I CG+ LH
Sbjct: 409 FLTHLICTFQTKDHLFFVMEFLNGGDLMYHIQDKGR--FELYRATFYAAEIMCGLQFLHS 466
Query: 310 LGIVYRDMKPENVLLDDLGNCRLSDLGLAVE-MKGGKPITQRAGTNGYMAPEILMEKVSY 368
GI+YRD+K +NVLLD G+ +++D G+ E + G + GT Y+APEIL + + Y
Sbjct: 467 KGIIYRDLKLDNVLLDRDGHIKIADFGMCKENIFGESRASTFCGTPDYIAPEIL-QGLKY 525
Query: 369 SYPVDWFAMGCSIYEMVAGRTPFKDYKEKVSKEDLKQRTLQDEVKFQHDNFTEEAKDICR 428
++ VDW++ G +YEM+ G++PF ED +++ + T+E+KDI
Sbjct: 526 TFSVDWWSFGVLLYEMLIGQSPFHG-----DDEDELFESIRVDTPHYPRWITKESKDILE 580
Query: 429 LFLAKKPEQRLGSREKSDDPRKHHFFKTINFPRLEAGLIEPPFVPDPSVVYAKDIAEIDD 488
++P +RLG + + + H FFKTIN+ LE +EPPF P V +D + D
Sbjct: 581 KLFEREPTKRLG---VTGNIKIHPFFKTINWTLLEKRRLEPPF--RPKVKSPRDYSNFDQ 635
Query: 489 --FSEVRGVEFDDKD 501
+E + + DK+
Sbjct: 636 EFLNEKARLSYSDKN 650
>gi|31377782 protein kinase C, delta [Homo sapiens]
Length = 676
Score = 178 bits (452), Expect = 1e-44
Identities = 110/315 (34%), Positives = 175/315 (55%), Gaps = 17/315 (5%)
Query: 191 FTEFRVLGKGGFGEVCAVQVKNTGKMYACKKLDKKRLKKKGGEKMALLEKEILEKVS-SP 249
F +VLGKG FG+V ++K G+ +A K L K + + ++EK +L + +P
Sbjct: 349 FIFHKVLGKGSFGKVLLGELKGRGEYFAIKALKKDVVLIDDDVECTMVEKRVLTLAAENP 408
Query: 250 FIVSLAYAFESKTHLCLVMSLMNGGDLKFHIYNVGTRGLDMSRVIFYSAQIACGMLHLHE 309
F+ L F++K HL VM +NGGDL +HI + G ++ R FY+A+I CG+ LH
Sbjct: 409 FLTHLICTFQTKDHLFFVMEFLNGGDLMYHIQDKGR--FELYRATFYAAEIMCGLQFLHS 466
Query: 310 LGIVYRDMKPENVLLDDLGNCRLSDLGLAVE-MKGGKPITQRAGTNGYMAPEILMEKVSY 368
GI+YRD+K +NVLLD G+ +++D G+ E + G + GT Y+APEIL + + Y
Sbjct: 467 KGIIYRDLKLDNVLLDRDGHIKIADFGMCKENIFGESRASTFCGTPDYIAPEIL-QGLKY 525
Query: 369 SYPVDWFAMGCSIYEMVAGRTPFKDYKEKVSKEDLKQRTLQDEVKFQHDNFTEEAKDICR 428
++ VDW++ G +YEM+ G++PF ED +++ + T+E+KDI
Sbjct: 526 TFSVDWWSFGVLLYEMLIGQSPFHG-----DDEDELFESIRVDTPHYPRWITKESKDILE 580
Query: 429 LFLAKKPEQRLGSREKSDDPRKHHFFKTINFPRLEAGLIEPPFVPDPSVVYAKDIAEIDD 488
++P +RLG + + + H FFKTIN+ LE +EPPF P V +D + D
Sbjct: 581 KLFEREPTKRLG---VTGNIKIHPFFKTINWTLLEKRRLEPPF--RPKVKSPRDYSNFDQ 635
Query: 489 --FSEVRGVEFDDKD 501
+E + + DK+
Sbjct: 636 EFLNEKARLSYSDKN 650
>gi|5453976 protein kinase C, theta [Homo sapiens]
Length = 706
Score = 176 bits (445), Expect = 7e-44
Identities = 112/327 (34%), Positives = 173/327 (52%), Gaps = 19/327 (5%)
Query: 191 FTEFRVLGKGGFGEVCAVQVKNTGKMYACKKLDKKRLKKKGGEKMALLEKEILEKV-SSP 249
F ++LGKG FG+V + K T + +A K L K + + ++EK +L P
Sbjct: 380 FILHKMLGKGSFGKVFLAEFKKTNQFFAIKALKKDVVLMDDDVECTMVEKRVLSLAWEHP 439
Query: 250 FIVSLAYAFESKTHLCLVMSLMNGGDLKFHIYNVGTRGLDMSRVIFYSAQIACGMLHLHE 309
F+ + F++K +L VM +NGGDL +HI + D+SR FY+A+I G+ LH
Sbjct: 440 FLTHMFCTFQTKENLFFVMEYLNGGDLMYHIQSC--HKFDLSRATFYAAEIILGLQFLHS 497
Query: 310 LGIVYRDMKPENVLLDDLGNCRLSDLGLAVE-MKGGKPITQRAGTNGYMAPEILMEKVSY 368
GIVYRD+K +N+LLD G+ +++D G+ E M G GT Y+APEIL+ + Y
Sbjct: 498 KGIVYRDLKLDNILLDKDGHIKIADFGMCKENMLGDAKTNTFCGTPDYIAPEILLGQ-KY 556
Query: 369 SYPVDWFAMGCSIYEMVAGRTPFKDYKEKVSKEDLKQRTLQDEVKFQHDNFTEEAKDICR 428
++ VDW++ G +YEM+ G++PF E E+L D F +EAKD+
Sbjct: 557 NHSVDWWSFGVLLYEMLIGQSPFHGQDE----EELFHSIRMDN-PFYPRWLEKEAKDLLV 611
Query: 429 LFLAKKPEQRLGSREKSDDPRKHHFFKTINFPRLEAGLIEPPFVPDPSVVYAKDIAEIDD 488
++PE+RLG R D R+H F+ IN+ LE I+PPF P + + +
Sbjct: 612 KLFVREPEKRLGVR---GDIRQHPLFREINWEELERKEIDPPFRPKVKSPFDCSNFDKEF 668
Query: 489 FSEVRGVEFDDK------DKQFFKNFA 509
+E + F D+ D+ F+NF+
Sbjct: 669 LNEKPRLSFADRALINSMDQNMFRNFS 695
>gi|47132591 protein kinase N1 isoform 1 [Homo sapiens]
Length = 948
Score = 174 bits (442), Expect = 1e-43
Identities = 109/294 (37%), Positives = 167/294 (56%), Gaps = 14/294 (4%)
Query: 185 PVSDKYFTEFRVLGKGGFGEVCAVQVKNTGKMYACKKLDKKRLKKKGGEKMALLEKEILE 244
P++ + F VLG+G FG+V + + +G+++A K L K + + + + EK IL
Sbjct: 615 PLTLEDFKFLAVLGRGHFGKVLLSEFRPSGELFAIKALKKGDIVARDEVESLMCEKRILA 674
Query: 245 KVSS---PFIVSLAYAFESKTHLCLVMSLMNGGDLKFHIYNVGTRGLDMSRVIFYSAQIA 301
V+S PF+V+L F++ H+C VM GGDL HI++ R IFYSA +
Sbjct: 675 AVTSAGHPFLVNLFGCFQTPEHVCFVMEYSAGGDLMLHIHS---DVFSEPRAIFYSACVV 731
Query: 302 CGMLHLHELGIVYRDMKPENVLLDDLGNCRLSDLGLAVEMKG-GKPITQRAGTNGYMAPE 360
G+ LHE IVYRD+K +N+LLD G +++D GL E G G + GT ++APE
Sbjct: 732 LGLQFLHEHKIVYRDLKLDNLLLDTEGYVKIADFGLCKEGMGYGDRTSTFCGTPEFLAPE 791
Query: 361 ILMEKVSYSYPVDWFAMGCSIYEMVAGRTPFKDYKEKVSKEDLKQRTLQDEVKFQHDNFT 420
+L + SY+ VDW+ +G +YEM+ G +PF E E++ + DEV++ +
Sbjct: 792 VLTD-TSYTRAVDWWGLGVLLYEMLVGESPFPGDDE----EEVFDSIVNDEVRYPR-FLS 845
Query: 421 EEAKDICRLFLAKKPEQRLGSREK-SDDPRKHHFFKTINFPRLEAGLIEPPFVP 473
EA I R L + PE+RLGS E+ ++D +K FF+T+ + L A + PPFVP
Sbjct: 846 AEAIGIMRRLLRRNPERRLGSSERDAEDVKKQPFFRTLGWEALLARRLPPPFVP 899
>gi|47132589 protein kinase N1 isoform 2 [Homo sapiens]
Length = 942
Score = 174 bits (442), Expect = 1e-43
Identities = 109/294 (37%), Positives = 167/294 (56%), Gaps = 14/294 (4%)
Query: 185 PVSDKYFTEFRVLGKGGFGEVCAVQVKNTGKMYACKKLDKKRLKKKGGEKMALLEKEILE 244
P++ + F VLG+G FG+V + + +G+++A K L K + + + + EK IL
Sbjct: 609 PLTLEDFKFLAVLGRGHFGKVLLSEFRPSGELFAIKALKKGDIVARDEVESLMCEKRILA 668
Query: 245 KVSS---PFIVSLAYAFESKTHLCLVMSLMNGGDLKFHIYNVGTRGLDMSRVIFYSAQIA 301
V+S PF+V+L F++ H+C VM GGDL HI++ R IFYSA +
Sbjct: 669 AVTSAGHPFLVNLFGCFQTPEHVCFVMEYSAGGDLMLHIHS---DVFSEPRAIFYSACVV 725
Query: 302 CGMLHLHELGIVYRDMKPENVLLDDLGNCRLSDLGLAVEMKG-GKPITQRAGTNGYMAPE 360
G+ LHE IVYRD+K +N+LLD G +++D GL E G G + GT ++APE
Sbjct: 726 LGLQFLHEHKIVYRDLKLDNLLLDTEGYVKIADFGLCKEGMGYGDRTSTFCGTPEFLAPE 785
Query: 361 ILMEKVSYSYPVDWFAMGCSIYEMVAGRTPFKDYKEKVSKEDLKQRTLQDEVKFQHDNFT 420
+L + SY+ VDW+ +G +YEM+ G +PF E E++ + DEV++ +
Sbjct: 786 VLTD-TSYTRAVDWWGLGVLLYEMLVGESPFPGDDE----EEVFDSIVNDEVRYPR-FLS 839
Query: 421 EEAKDICRLFLAKKPEQRLGSREK-SDDPRKHHFFKTINFPRLEAGLIEPPFVP 473
EA I R L + PE+RLGS E+ ++D +K FF+T+ + L A + PPFVP
Sbjct: 840 AEAIGIMRRLLRRNPERRLGSSERDAEDVKKQPFFRTLGWEALLARRLPPPFVP 893
>gi|4506067 protein kinase C, alpha [Homo sapiens]
Length = 672
Score = 174 bits (441), Expect = 2e-43
Identities = 105/286 (36%), Positives = 160/286 (55%), Gaps = 11/286 (3%)
Query: 191 FTEFRVLGKGGFGEVCAVQVKNTGKMYACKKLDKKRLKKKGGEKMALLEKEILEKVSSP- 249
F VLGKG FG+V K T ++YA K L K + + + ++EK +L + P
Sbjct: 339 FNFLMVLGKGSFGKVMLADRKGTEELYAIKILKKDVVIQDDDVECTMVEKRVLALLDKPP 398
Query: 250 FIVSLAYAFESKTHLCLVMSLMNGGDLKFHIYNVGTRGLDMSRVIFYSAQIACGMLHLHE 309
F+ L F++ L VM +NGGDL +HI VG + +FY+A+I+ G+ LH+
Sbjct: 399 FLTQLHSCFQTVDRLYFVMEYVNGGDLMYHIQQVGK--FKEPQAVFYAAEISIGLFFLHK 456
Query: 310 LGIVYRDMKPENVLLDDLGNCRLSDLGLAVE-MKGGKPITQRAGTNGYMAPEILMEKVSY 368
GI+YRD+K +NV+LD G+ +++D G+ E M G GT Y+APEI+ + Y
Sbjct: 457 RGIIYRDLKLDNVMLDSEGHIKIADFGMCKEHMMDGVTTRTFCGTPDYIAPEIIAYQ-PY 515
Query: 369 SYPVDWFAMGCSIYEMVAGRTPFKDYKEKVSKEDLKQRTLQDEVKFQHDNFTEEAKDICR 428
VDW+A G +YEM+AG+ PF E ++L Q ++ V + + ++EA IC+
Sbjct: 516 GKSVDWWAYGVLLYEMLAGQPPFDGEDE----DELFQSIMEHNVSYP-KSLSKEAVSICK 570
Query: 429 LFLAKKPEQRLG-SREKSDDPRKHHFFKTINFPRLEAGLIEPPFVP 473
+ K P +RLG E D R+H FF+ I++ +LE I+PPF P
Sbjct: 571 GLMTKHPAKRLGCGPEGERDVREHAFFRRIDWEKLENREIQPPFKP 616
>gi|133908623 protein kinase C, iota [Homo sapiens]
Length = 596
Score = 174 bits (441), Expect = 2e-43
Identities = 106/320 (33%), Positives = 181/320 (56%), Gaps = 13/320 (4%)
Query: 191 FTEFRVLGKGGFGEVCAVQVKNTGKMYACKKLDKKRLKKKGGEKMALLEKEILEKVSS-P 249
F RV+G+G + +V V++K T ++YA K + K+ + EK + E+ S+ P
Sbjct: 254 FDLLRVIGRGSYAKVLLVRLKKTDRIYAMKVVKKELVNDDEDIDWVQTEKHVFEQASNHP 313
Query: 250 FIVSLAYAFESKTHLCLVMSLMNGGDLKFHIYNVGTRGLDMSRVIFYSAQIACGMLHLHE 309
F+V L F++++ L V+ +NGGDL FH+ R L FYSA+I+ + +LHE
Sbjct: 314 FLVGLHSCFQTESRLFFVIEYVNGGDLMFHMQR--QRKLPEEHARFYSAEISLALNYLHE 371
Query: 310 LGIVYRDMKPENVLLDDLGNCRLSDLGLAVE-MKGGKPITQRAGTNGYMAPEILMEKVSY 368
GI+YRD+K +NVLLD G+ +L+D G+ E ++ G + GT Y+APEIL + Y
Sbjct: 372 RGIIYRDLKLDNVLLDSEGHIKLTDYGMCKEGLRPGDTTSTFCGTPNYIAPEILRGE-DY 430
Query: 369 SYPVDWFAMGCSIYEMVAGRTPF-----KDYKEKVSKEDLKQRTLQDEVKFQHDNFTEEA 423
+ VDW+A+G ++EM+AGR+PF D ++ +++ L Q L+ +++ + + +A
Sbjct: 431 GFSVDWWALGVLMFEMMAGRSPFDIVGSSDNPDQNTEDYLFQVILEKQIRIPR-SLSVKA 489
Query: 424 KDICRLFLAKKPEQRLGSREKSD--DPRKHHFFKTINFPRLEAGLIEPPFVPDPSVVYAK 481
+ + FL K P++RLG ++ D + H FF+ +++ +E + PPF P+ S +
Sbjct: 490 ASVLKSFLNKDPKERLGCHPQTGFADIQGHPFFRNVDWDMMEQKQVVPPFKPNISGEFGL 549
Query: 482 DIAEIDDFSEVRGVEFDDKD 501
D + +E + DD D
Sbjct: 550 DNFDSQFTNEPVQLTPDDDD 569
>gi|4506055 cAMP-dependent protein kinase catalytic subunit alpha
isoform 1 [Homo sapiens]
Length = 351
Score = 173 bits (439), Expect = 3e-43
Identities = 112/352 (31%), Positives = 187/352 (53%), Gaps = 14/352 (3%)
Query: 159 QEQPFKDFVTSAFYDKFLQWKLFEMQPVSDKYFTEFRVLGKGGFGEVCAVQVKNTGKMYA 218
+++ K+F+ A D +W+ F + LG G FG V V+ K TG YA
Sbjct: 12 EQESVKEFLAKAKEDFLKKWESPAQNTAHLDQFERIKTLGTGSFGRVMLVKHKETGNHYA 71
Query: 219 CKKLDKKRLKKKGGEKMALLEKEILEKVSSPFIVSLAYAFESKTHLCLVMSLMNGGDLKF 278
K LDK+++ K + L EK IL+ V+ PF+V L ++F+ ++L +VM + GG++
Sbjct: 72 MKILDKQKVVKLKQIEHTLNEKRILQAVNFPFLVKLEFSFKDNSNLYMVMEYVPGGEMFS 131
Query: 279 HIYNVGTRGLDMSRVIFYSAQIACGMLHLHELGIVYRDMKPENVLLDDLGNCRLSDLGLA 338
H+ +G +R FY+AQI +LH L ++YRD+KPEN+L+D G +++D G A
Sbjct: 132 HLRRIGRFSEPHAR--FYAAQIVLTFEYLHSLDLIYRDLKPENLLIDQQGYIQVTDFGFA 189
Query: 339 VEMKGGKPITQRAGTNGYMAPEILMEKVSYSYPVDWFAMGCSIYEMVAGRTPFKDYKEKV 398
+KG GT Y+APEI++ K Y+ VDW+A+G IYEM AG PF + ++
Sbjct: 190 KRVKG--RTWTLCGTPEYLAPEIILSK-GYNKAVDWWALGVLIYEMAAGYPPF--FADQP 244
Query: 399 SKEDLKQRTLQDEVKFQHDNFTEEAKDICRLFLAKKPEQRLGSREKS-DDPRKHHFFKTI 457
+ + ++ + +V+F +F+ + KD+ R L +R G+ + +D + H +F T
Sbjct: 245 IQ--IYEKIVSGKVRFP-SHFSSDLKDLLRNLLQVDLTKRFGNLKNGVNDIKNHKWFATT 301
Query: 458 NFPRLEAGLIEPPFVPDPSVVYAKDIAEIDDFSEVR-GVEFDDKDKQFFKNF 508
++ + +E PF+ P D + DD+ E V ++K + F F
Sbjct: 302 DWIAIYQRKVEAPFI--PKFKGPGDTSNFDDYEEEEIRVSINEKCGKEFSEF 351
>gi|46909584 cAMP-dependent protein kinase catalytic subunit alpha
isoform 2 [Homo sapiens]
Length = 343
Score = 172 bits (435), Expect = 9e-43
Identities = 112/347 (32%), Positives = 184/347 (53%), Gaps = 14/347 (4%)
Query: 164 KDFVTSAFYDKFLQWKLFEMQPVSDKYFTEFRVLGKGGFGEVCAVQVKNTGKMYACKKLD 223
K+F+ A D +W+ F + LG G FG V V+ K TG YA K LD
Sbjct: 9 KEFLAKAKEDFLKKWESPAQNTAHLDQFERIKTLGTGSFGRVMLVKHKETGNHYAMKILD 68
Query: 224 KKRLKKKGGEKMALLEKEILEKVSSPFIVSLAYAFESKTHLCLVMSLMNGGDLKFHIYNV 283
K+++ K + L EK IL+ V+ PF+V L ++F+ ++L +VM + GG++ H+ +
Sbjct: 69 KQKVVKLKQIEHTLNEKRILQAVNFPFLVKLEFSFKDNSNLYMVMEYVPGGEMFSHLRRI 128
Query: 284 GTRGLDMSRVIFYSAQIACGMLHLHELGIVYRDMKPENVLLDDLGNCRLSDLGLAVEMKG 343
G +R FY+AQI +LH L ++YRD+KPEN+L+D G +++D G A +KG
Sbjct: 129 GRFSEPHAR--FYAAQIVLTFEYLHSLDLIYRDLKPENLLIDQQGYIQVTDFGFAKRVKG 186
Query: 344 GKPITQRAGTNGYMAPEILMEKVSYSYPVDWFAMGCSIYEMVAGRTPFKDYKEKVSKEDL 403
GT Y+APEI++ K Y+ VDW+A+G IYEM AG PF + ++ + +
Sbjct: 187 --RTWTLCGTPEYLAPEIILSK-GYNKAVDWWALGVLIYEMAAGYPPF--FADQPIQ--I 239
Query: 404 KQRTLQDEVKFQHDNFTEEAKDICRLFLAKKPEQRLGSREKS-DDPRKHHFFKTINFPRL 462
++ + +V+F +F+ + KD+ R L +R G+ + +D + H +F T ++ +
Sbjct: 240 YEKIVSGKVRFP-SHFSSDLKDLLRNLLQVDLTKRFGNLKNGVNDIKNHKWFATTDWIAI 298
Query: 463 EAGLIEPPFVPDPSVVYAKDIAEIDDFSEVR-GVEFDDKDKQFFKNF 508
+E PF+ P D + DD+ E V ++K + F F
Sbjct: 299 YQRKVEAPFI--PKFKGPGDTSNFDDYEEEEIRVSINEKCGKEFSEF 343
>gi|55953117 ribosomal protein S6 kinase, 70kDa, polypeptide 2 [Homo
sapiens]
Length = 482
Score = 171 bits (433), Expect = 2e-42
Identities = 108/303 (35%), Positives = 168/303 (55%), Gaps = 16/303 (5%)
Query: 191 FTEFRVLGKGGFGEVCAV---QVKNTGKMYACKKLDKKRLKKKGGEKM-ALLEKEILEKV 246
F RVLGKGG+G+V V Q N GK+YA K L K ++ + + E+ ILE V
Sbjct: 67 FELLRVLGKGGYGKVFQVRKVQGTNLGKIYAMKVLRKAKIVRNAKDTAHTRAERNILESV 126
Query: 247 SSPFIVSLAYAFESKTHLCLVMSLMNGGDLKFHIYNVGTRGLDMSRVIFYSAQIACGMLH 306
PFIV LAYAF++ L L++ ++GG+L H+ G D + FY A+I + H
Sbjct: 127 KHPFIVELAYAFQTGGKLYLILECLSGGELFTHLEREGIFLEDTA--CFYLAEITLALGH 184
Query: 307 LHELGIVYRDMKPENVLLDDLGNCRLSDLGLAVEMKGGKPITQR-AGTNGYMAPEILMEK 365
LH GI+YRD+KPEN++L G+ +L+D GL E +T GT YMAPEIL+ +
Sbjct: 185 LHSQGIIYRDLKPENIMLSSQGHIKLTDFGLCKESIHEGAVTHTFCGTIEYMAPEILV-R 243
Query: 366 VSYSYPVDWFAMGCSIYEMVAGRTPFKDYKEKVSKEDLKQRTLQDEVKFQHDNFTEEAKD 425
++ VDW+++G +Y+M+ G PF K + + + + L T +A+D
Sbjct: 244 SGHNRAVDWWSLGALMYDMLTGSPPFTAENRKKTMDKIIRGKLA-----LPPYLTPDARD 298
Query: 426 ICRLFLAKKPEQRLGSRE-KSDDPRKHHFFKTINFPRLEAGLIEPPFVPDPSVVYAKDIA 484
+ + FL + P QR+G + D ++H FF+ +N+ L A ++PPF P + +D++
Sbjct: 299 LVKKFLKRNPSQRIGGGPGDAADVQRHPFFRHMNWDDLLAWRVDPPF--RPCLQSEEDVS 356
Query: 485 EID 487
+ D
Sbjct: 357 QFD 359
>gi|4502023 AKT2 kinase [Homo sapiens]
Length = 481
Score = 170 bits (431), Expect = 3e-42
Identities = 108/314 (34%), Positives = 161/314 (51%), Gaps = 12/314 (3%)
Query: 191 FTEFRVLGKGGFGEVCAVQVKNTGKMYACKKLDKKRLKKKGGEKMALLEKEILEKVSSPF 250
F ++LGKG FG+V V+ K TG+ YA K L K+ + K + E +L+ PF
Sbjct: 152 FDYLKLLGKGTFGKVILVREKATGRYYAMKILRKEVIIAKDEVAHTVTESRVLQNTRHPF 211
Query: 251 IVSLAYAFESKTHLCLVMSLMNGGDLKFHIYNVGTRGLDMSRVIFYSAQIACGMLHLHEL 310
+ +L YAF++ LC VM NGG+L FH+ R R FY A+I + +LH
Sbjct: 212 LTALKYAFQTHDRLCFVMEYANGGELFFHLSR--ERVFTEERARFYGAEIVSALEYLHSR 269
Query: 311 GIVYRDMKPENVLLDDLGNCRLSDLGLAVE-MKGGKPITQRAGTNGYMAPEILMEKVSYS 369
+VYRD+K EN++LD G+ +++D GL E + G + GT Y+APE+L E Y
Sbjct: 270 DVVYRDIKLENLMLDKDGHIKITDFGLCKEGISDGATMKTFCGTPEYLAPEVL-EDNDYG 328
Query: 370 YPVDWFAMGCSIYEMVAGRTPFKDYKEKVSKEDLKQRTLQDEVKFQHDNFTEEAKDICRL 429
VDW+ +G +YEM+ GR PF + E L + L +E++F + EAK +
Sbjct: 329 RAVDWWGLGVVMYEMMCGRLPFYNQ----DHERLFELILMEEIRFPR-TLSPEAKSLLAG 383
Query: 430 FLAKKPEQRL-GSREKSDDPRKHHFFKTINFPRLEAGLIEPPFVPDPSVVYAKDIAEIDD 488
L K P+QRL G + + +H FF +IN+ + + PPF P V D DD
Sbjct: 384 LLKKDPKQRLGGGPSDAKEVMEHRFFLSINWQDVVQKKLLPPF--KPQVTSEVDTRYFDD 441
Query: 489 FSEVRGVEFDDKDK 502
+ + D+
Sbjct: 442 EFTAQSITITPPDR 455
>gi|75709228 protein kinase C, zeta isoform 2 [Homo sapiens]
Length = 409
Score = 170 bits (430), Expect = 4e-42
Identities = 111/318 (34%), Positives = 175/318 (55%), Gaps = 11/318 (3%)
Query: 191 FTEFRVLGKGGFGEVCAVQVKNTGKMYACKKLDKKRLKKKGGEKMALLEKEILEKVSS-P 249
F RV+G+G + +V V++K ++YA K + K+ + EK + E+ SS P
Sbjct: 69 FDLIRVIGRGSYAKVLLVRLKKNDQIYAMKVVKKELVHDDEDIDWVQTEKHVFEQASSNP 128
Query: 250 FIVSLAYAFESKTHLCLVMSLMNGGDLKFHIYNVGTRGLDMSRVIFYSAQIACGMLHLHE 309
F+V L F++ + L LV+ +NGGDL FH+ R L FY+A+I + LHE
Sbjct: 129 FLVGLHSCFQTTSRLFLVIEYVNGGDLMFHMQR--QRKLPEEHARFYAAEICIALNFLHE 186
Query: 310 LGIVYRDMKPENVLLDDLGNCRLSDLGLAVEMKG-GKPITQRAGTNGYMAPEILMEKVSY 368
GI+YRD+K +NVLLD G+ +L+D G+ E G G + GT Y+APEIL + Y
Sbjct: 187 RGIIYRDLKLDNVLLDADGHIKLTDYGMCKEGLGPGDTTSTFCGTPNYIAPEILRGE-EY 245
Query: 369 SYPVDWFAMGCSIYEMVAGRTPF---KDYKEKVSKEDLKQRTLQDEVKFQHDNFTEEAKD 425
+ VDW+A+G ++EM+AGR+PF D + +++ L Q L+ ++ + +A
Sbjct: 246 GFSVDWWALGVLMFEMMAGRSPFDIITDNPDMNTEDYLFQVILEKPIRIPR-FLSVKASH 304
Query: 426 ICRLFLAKKPEQRLGSREKS--DDPRKHHFFKTINFPRLEAGLIEPPFVPDPSVVYAKDI 483
+ + FL K P++RLG R ++ D + H FF++I++ LE PPF P + Y D
Sbjct: 305 VLKGFLNKDPKERLGCRPQTGFSDIKSHAFFRSIDWDLLEKKQALPPFQPQITDDYGLDN 364
Query: 484 AEIDDFSEVRGVEFDDKD 501
+ SE + DD+D
Sbjct: 365 FDTQFTSEPVQLTPDDED 382
>gi|75709226 protein kinase C, zeta isoform 2 [Homo sapiens]
Length = 409
Score = 170 bits (430), Expect = 4e-42
Identities = 111/318 (34%), Positives = 175/318 (55%), Gaps = 11/318 (3%)
Query: 191 FTEFRVLGKGGFGEVCAVQVKNTGKMYACKKLDKKRLKKKGGEKMALLEKEILEKVSS-P 249
F RV+G+G + +V V++K ++YA K + K+ + EK + E+ SS P
Sbjct: 69 FDLIRVIGRGSYAKVLLVRLKKNDQIYAMKVVKKELVHDDEDIDWVQTEKHVFEQASSNP 128
Query: 250 FIVSLAYAFESKTHLCLVMSLMNGGDLKFHIYNVGTRGLDMSRVIFYSAQIACGMLHLHE 309
F+V L F++ + L LV+ +NGGDL FH+ R L FY+A+I + LHE
Sbjct: 129 FLVGLHSCFQTTSRLFLVIEYVNGGDLMFHMQR--QRKLPEEHARFYAAEICIALNFLHE 186
Query: 310 LGIVYRDMKPENVLLDDLGNCRLSDLGLAVEMKG-GKPITQRAGTNGYMAPEILMEKVSY 368
GI+YRD+K +NVLLD G+ +L+D G+ E G G + GT Y+APEIL + Y
Sbjct: 187 RGIIYRDLKLDNVLLDADGHIKLTDYGMCKEGLGPGDTTSTFCGTPNYIAPEILRGE-EY 245
Query: 369 SYPVDWFAMGCSIYEMVAGRTPF---KDYKEKVSKEDLKQRTLQDEVKFQHDNFTEEAKD 425
+ VDW+A+G ++EM+AGR+PF D + +++ L Q L+ ++ + +A
Sbjct: 246 GFSVDWWALGVLMFEMMAGRSPFDIITDNPDMNTEDYLFQVILEKPIRIPR-FLSVKASH 304
Query: 426 ICRLFLAKKPEQRLGSREKS--DDPRKHHFFKTINFPRLEAGLIEPPFVPDPSVVYAKDI 483
+ + FL K P++RLG R ++ D + H FF++I++ LE PPF P + Y D
Sbjct: 305 VLKGFLNKDPKERLGCRPQTGFSDIKSHAFFRSIDWDLLEKKQALPPFQPQITDDYGLDN 364
Query: 484 AEIDDFSEVRGVEFDDKD 501
+ SE + DD+D
Sbjct: 365 FDTQFTSEPVQLTPDDED 382
>gi|52486327 protein kinase C, zeta isoform 1 [Homo sapiens]
Length = 592
Score = 170 bits (430), Expect = 4e-42
Identities = 111/318 (34%), Positives = 175/318 (55%), Gaps = 11/318 (3%)
Query: 191 FTEFRVLGKGGFGEVCAVQVKNTGKMYACKKLDKKRLKKKGGEKMALLEKEILEKVSS-P 249
F RV+G+G + +V V++K ++YA K + K+ + EK + E+ SS P
Sbjct: 252 FDLIRVIGRGSYAKVLLVRLKKNDQIYAMKVVKKELVHDDEDIDWVQTEKHVFEQASSNP 311
Query: 250 FIVSLAYAFESKTHLCLVMSLMNGGDLKFHIYNVGTRGLDMSRVIFYSAQIACGMLHLHE 309
F+V L F++ + L LV+ +NGGDL FH+ R L FY+A+I + LHE
Sbjct: 312 FLVGLHSCFQTTSRLFLVIEYVNGGDLMFHMQR--QRKLPEEHARFYAAEICIALNFLHE 369
Query: 310 LGIVYRDMKPENVLLDDLGNCRLSDLGLAVEMKG-GKPITQRAGTNGYMAPEILMEKVSY 368
GI+YRD+K +NVLLD G+ +L+D G+ E G G + GT Y+APEIL + Y
Sbjct: 370 RGIIYRDLKLDNVLLDADGHIKLTDYGMCKEGLGPGDTTSTFCGTPNYIAPEILRGE-EY 428
Query: 369 SYPVDWFAMGCSIYEMVAGRTPF---KDYKEKVSKEDLKQRTLQDEVKFQHDNFTEEAKD 425
+ VDW+A+G ++EM+AGR+PF D + +++ L Q L+ ++ + +A
Sbjct: 429 GFSVDWWALGVLMFEMMAGRSPFDIITDNPDMNTEDYLFQVILEKPIRIPR-FLSVKASH 487
Query: 426 ICRLFLAKKPEQRLGSREKS--DDPRKHHFFKTINFPRLEAGLIEPPFVPDPSVVYAKDI 483
+ + FL K P++RLG R ++ D + H FF++I++ LE PPF P + Y D
Sbjct: 488 VLKGFLNKDPKERLGCRPQTGFSDIKSHAFFRSIDWDLLEKKQALPPFQPQITDDYGLDN 547
Query: 484 AEIDDFSEVRGVEFDDKD 501
+ SE + DD+D
Sbjct: 548 FDTQFTSEPVQLTPDDED 565
>gi|47157322 protein kinase C, beta isoform 1 [Homo sapiens]
Length = 671
Score = 170 bits (430), Expect = 4e-42
Identities = 110/320 (34%), Positives = 169/320 (52%), Gaps = 13/320 (4%)
Query: 191 FTEFRVLGKGGFGEVCAVQVKNTGKMYACKKLDKKRLKKKGGEKMALLEKEILEKVSSP- 249
F VLGKG FG+V + K T ++YA K L K + + + ++EK +L P
Sbjct: 342 FNFLMVLGKGSFGKVMLSERKGTDELYAVKILKKDVVIQDDDVECTMVEKRVLALPGKPP 401
Query: 250 FIVSLAYAFESKTHLCLVMSLMNGGDLKFHIYNVGTRGLDMSRVIFYSAQIACGMLHLHE 309
F+ L F++ L VM +NGGDL +HI VG +FY+A+IA G+ L
Sbjct: 402 FLTQLHSCFQTMDRLYFVMEYVNGGDLMYHIQQVGR--FKEPHAVFYAAEIAIGLFFLQS 459
Query: 310 LGIVYRDMKPENVLLDDLGNCRLSDLGLAVE-MKGGKPITQRAGTNGYMAPEILMEKVSY 368
GI+YRD+K +NV+LD G+ +++D G+ E + G GT Y+APEI+ + Y
Sbjct: 460 KGIIYRDLKLDNVMLDSEGHIKIADFGMCKENIWDGVTTKTFCGTPDYIAPEIIAYQ-PY 518
Query: 369 SYPVDWFAMGCSIYEMVAGRTPFKDYKEKVSKEDLKQRTLQDEVKFQHDNFTEEAKDICR 428
VDW+A G +YEM+AG+ PF E +++L Q ++ V + + ++EA IC+
Sbjct: 519 GKSVDWWAFGVLLYEMLAGQAPF----EGEDEDELFQSIMEHNVAYP-KSMSKEAVAICK 573
Query: 429 LFLAKKPEQRLG-SREKSDDPRKHHFFKTINFPRLEAGLIEPPFVPDPSVVYAKDIAEID 487
+ K P +RLG E D ++H FF+ I++ +LE I+PP+ P +D + D
Sbjct: 574 GLMTKHPGKRLGCGPEGERDIKEHAFFRYIDWEKLERKEIQPPY--KPKARDKRDTSNFD 631
Query: 488 DFSEVRGVEFDDKDKQFFKN 507
+ VE DK F N
Sbjct: 632 KEFTRQPVELTPTDKLFIMN 651
>gi|33636738 cAMP-dependent protein kinase catalytic subunit beta
isoform 1 [Homo sapiens]
Length = 398
Score = 170 bits (430), Expect = 4e-42
Identities = 110/335 (32%), Positives = 181/335 (54%), Gaps = 13/335 (3%)
Query: 158 LQEQPFKDFVTSAFYDKFLQWKLFEMQPVSDKYFTEFRVLGKGGFGEVCAVQVKNTGKMY 217
L ++ K+F+ A D +W+ + F + LG G FG V V+ K T + Y
Sbjct: 58 LWDRSMKEFLAKAKEDFLKKWENPTQNNAGLEDFERKKTLGTGSFGRVMLVKHKATEQYY 117
Query: 218 ACKKLDKKRLKKKGGEKMALLEKEILEKVSSPFIVSLAYAFESKTHLCLVMSLMNGGDLK 277
A K LDK+++ K + L EK IL+ V+ PF+V L YAF+ ++L +VM + GG++
Sbjct: 118 AMKILDKQKVVKLKQIEHTLNEKRILQAVNFPFLVRLEYAFKDNSNLYMVMEYVPGGEMF 177
Query: 278 FHIYNVGTRGLDMSRVIFYSAQIACGMLHLHELGIVYRDMKPENVLLDDLGNCRLSDLGL 337
H+ +G +R FY+AQI +LH L ++YRD+KPEN+L+D G +++D G
Sbjct: 178 SHLRRIGRFSEPHAR--FYAAQIVLTFEYLHSLDLIYRDLKPENLLIDHQGYIQVTDFGF 235
Query: 338 AVEMKGGKPITQRAGTNGYMAPEILMEKVSYSYPVDWFAMGCSIYEMVAGRTPFKDYKEK 397
A +KG GT Y+APEI++ K Y+ VDW+A+G IYEM AG PF + ++
Sbjct: 236 AKRVKG--RTWTLCGTPEYLAPEIILSK-GYNKAVDWWALGVLIYEMAAGYPPF--FADQ 290
Query: 398 VSKEDLKQRTLQDEVKFQHDNFTEEAKDICRLFLAKKPEQRLGSREKS-DDPRKHHFFKT 456
+ + ++ + +V+F +F+ + KD+ R L +R G+ + D + H +F T
Sbjct: 291 PIQ--IYEKIVSGKVRFP-SHFSSDLKDLLRNLLQVDLTKRFGNLKNGVSDIKTHKWFAT 347
Query: 457 INFPRLEAGLIEPPFVPDPSVVYAKDIAEIDDFSE 491
++ + +E PF+ P + D + DD+ E
Sbjct: 348 TDWIAIYQRKVEAPFI--PKFRGSGDTSNFDDYEE 380
Database: hs.faa
Posted date: Aug 4, 2009 4:42 PM
Number of letters in database: 18,247,518
Number of sequences in database: 37,866
Lambda K H
0.320 0.136 0.403
Gapped
Lambda K H
0.267 0.0410 0.140
Matrix: BLOSUM62
Gap Penalties: Existence: 11, Extension: 1
Number of Hits to DB: 21,665,092
Number of Sequences: 37866
Number of extensions: 1001170
Number of successful extensions: 4633
Number of sequences better than 10.0: 30
Number of HSP's better than 10.0 without gapping: 677
Number of HSP's successfully gapped in prelim test: 104
Number of HSP's that attempted gapping in prelim test: 2527
Number of HSP's gapped (non-prelim): 950
length of query: 553
length of database: 18,247,518
effective HSP length: 107
effective length of query: 446
effective length of database: 14,195,856
effective search space: 6331351776
effective search space used: 6331351776
T: 11
A: 40
X1: 16 ( 7.4 bits)
X2: 38 (14.6 bits)
X3: 64 (24.7 bits)
S1: 41 (21.8 bits)
S2: 64 (29.3 bits)
Search results were obtained with NCBI BLAST and RefSeq entries.
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Guide to the Human Genome
Copyright © 2010 by Stewart Scherer. All rights reserved.